17 CFR 242.600 - NMS security designation and definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Interrogation device means any securities information retrieval system capable of displaying transaction reports... with respect to such order; and (v) Immediately and automatically displays information that updates the... security; and (ii) Consolidated last sale information for a security. (14) Consolidated last sale...

17 CFR 242.600 - NMS security designation and definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Interrogation device means any securities information retrieval system capable of displaying transaction reports... with respect to such order; and (v) Immediately and automatically displays information that updates the... security; and (ii) Consolidated last sale information for a security. (14) Consolidated last sale...

17 CFR 242.600 - NMS security designation and definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) Interrogation device means any securities information retrieval system capable of displaying transaction reports... with respect to such order; and (v) Immediately and automatically displays information that updates the... security; and (ii) Consolidated last sale information for a security. (14) Consolidated last sale...

17 CFR 242.600 - NMS security designation and definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) Interrogation device means any securities information retrieval system capable of displaying transaction reports... with respect to such order; and (v) Immediately and automatically displays information that updates the... security; and (ii) Consolidated last sale information for a security. (14) Consolidated last sale...

[Interpretation of update on The AJCC Esophageal Cancer Staging System, Eighth Edition].

PubMed

Yuan, Y; Chen, L Q

2017-02-01

The recently published AJCC Esophageal Cancer Staging System, 8(th) Edition will be implemented on Januray 1, 2018, which was developed by Worldwide Esophageal Cancer Collaboration based on 22 654 esophageal cancer patients from 33 worldwide centers. The definition of T, N, M, G stage and regional lymph nodes were optimized in the 8(th) edition. And the new "2 cm" principle has simplified the definition for the cancer of esophagogastric junction. In addition to pathologic staging, the 8(th) edition also provided clinical staging and pathologic staging after neoadjuvant therapy, making the new esophageal cancer staging system more practicable and reasonable.

Real time method and computer system for identifying radioactive materials from HPGe gamma-ray spectroscopy

DOEpatents

Rowland, Mark S.; Howard, Douglas E.; Wong, James L.; Jessup, James L.; Bianchini, Greg M.; Miller, Wayne O.

2007-10-23

A real-time method and computer system for identifying radioactive materials which collects gamma count rates from a HPGe gamma-radiation detector to produce a high-resolution gamma-ray energy spectrum. A library of nuclear material definitions ("library definitions") is provided, with each uniquely associated with a nuclide or isotope material and each comprising at least one logic condition associated with a spectral parameter of a gamma-ray energy spectrum. The method determines whether the spectral parameters of said high-resolution gamma-ray energy spectrum satisfy all the logic conditions of any one of the library definitions, and subsequently uniquely identifies the material type as that nuclide or isotope material associated with the satisfied library definition. The method is iteratively repeated to update the spectrum and identification in real time.

INTERNATIONAL REPORT: Practical realization of the definition of the metre, including recommended radiations of other optical frequency standards (2003)

NASA Astrophysics Data System (ADS)

Felder, R.

2005-08-01

In 2003, the International Committee for Weights and Measures (CIPM) recommended updated values of the frequency for certain optical frequency standards recommended for the practical realization of the definition of the metre. The text of this CIPM Recommendation and details of the updated radiations are given here. The complete updated set of recommended radiations, including frequencies, wavelengths, uncertainties and operating conditions where appropriate, is available on the BIPM website.

The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After.

PubMed

Bassi, Claudio; Marchegiani, Giovanni; Dervenis, Christos; Sarr, Micheal; Abu Hilal, Mohammad; Adham, Mustapha; Allen, Peter; Andersson, Roland; Asbun, Horacio J; Besselink, Marc G; Conlon, Kevin; Del Chiaro, Marco; Falconi, Massimo; Fernandez-Cruz, Laureano; Fernandez-Del Castillo, Carlos; Fingerhut, Abe; Friess, Helmut; Gouma, Dirk J; Hackert, Thilo; Izbicki, Jakob; Lillemoe, Keith D; Neoptolemos, John P; Olah, Attila; Schulick, Richard; Shrikhande, Shailesh V; Takada, Tadahiro; Takaori, Kyoichi; Traverso, William; Vollmer, Charles R; Wolfgang, Christopher L; Yeo, Charles J; Salvia, Roberto; Buchler, Marcus

2017-03-01

In 2005, the International Study Group of Pancreatic Fistula developed a definition and grading of postoperative pancreatic fistula that has been accepted universally. Eleven years later, because postoperative pancreatic fistula remains one of the most relevant and harmful complications of pancreatic operation, the International Study Group of Pancreatic Fistula classification has become the gold standard in defining postoperative pancreatic fistula in clinical practice. The aim of the present report is to verify the value of the International Study Group of Pancreatic Fistula definition and grading of postoperative pancreatic fistula and to update the International Study Group of Pancreatic Fistula classification in light of recent evidence that has emerged, as well as to address the lingering controversies about the original definition and grading of postoperative pancreatic fistula. The International Study Group of Pancreatic Fistula reconvened as the International Study Group in Pancreatic Surgery in order to perform a review of the recent literature and consequently to update and revise the grading system of postoperative pancreatic fistula. Based on the literature since 2005 investigating the validity and clinical use of the original International Study Group of Pancreatic Fistula classification, a clinically relevant postoperative pancreatic fistula is now redefined as a drain output of any measurable volume of fluid with an amylase level >3 times the upper limit of institutional normal serum amylase activity, associated with a clinically relevant development/condition related directly to the postoperative pancreatic fistula. Consequently, the former "grade A postoperative pancreatic fistula" is now redefined and called a "biochemical leak," because it has no clinical importance and is no longer referred to a true pancreatic fistula. Postoperative pancreatic fistula grades B and C are confirmed but defined more strictly. In particular, grade B requires a change in the postoperative management; drains are either left in place >3 weeks or repositioned through endoscopic or percutaneous procedures. Grade C postoperative pancreatic fistula refers to those postoperative pancreatic fistula that require reoperation or lead to single or multiple organ failure and/or mortality attributable to the pancreatic fistula. This new definition and grading system of postoperative pancreatic fistula should lead to a more universally consistent evaluation of operative outcomes after pancreatic operation and will allow for a better comparison of techniques used to mitigate the rate and clinical impact of a pancreatic fistula. Use of this updated classification will also allow for more precise comparisons of surgical quality between surgeons and units who perform pancreatic surgery. Copyright © 2016 Elsevier Inc. All rights reserved.

Defining delirium for the International Classification of Diseases, 11th Revision.

PubMed

Meagher, David J; Maclullich, Alasdair M J; Laurila, Jouko V

2008-09-01

The development of ICD-11 provides an opportunity to update the description of delirium according to emerging data that have added to our understanding of this complex neuropsychiatric syndrome. Synthetic article based on published work considered by the authors to be relevant to the definition of delirium. The current DSM-IV definition of delirium is preferred to the ICD-10 because of its greater inclusivity. Evidence does not support major changes in the principal components of present definitions but a number of key issues for the updated definition were identified. These include better account of non-cognitive features, more guidance for rating contextual diagnostic items, clearer definition regarding the interface with dementia, and accounting for illness severity, clinical subtypes and course. Development of the ICD definition of delirium can allow for more targeted research and clinical effort.

The Design and Implementation of the Ariel Active Database Rule System

DTIC Science & Technology

1991-10-01

but only as a main-memory prototype. The POSTGRES rule system (PRS) [SHP88, SRH90] and the Starburst rule system (SRS) [WCL91, HCL+90] have been...query language of POSTGRES for specifying data definition commands, queries and updates [SRH90]. POSTQUEL commands retrieve, append, delete, and replace...placed on an arbitrary attribute (e.g., one without an index) ( POSTGRES rule system [SHP88, SHP89, SR1I90], HiPAC [C+891, DIPS [SLR89], Alert [SPAM91

Requirements Analysis Study for Master Pump Shutdown System Project Development Specification [SEC 1 and 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

BEVINS, R.R.

This document has been updated during the definitive design portion of the first phase of the W-314 Project to capture additional software requirements and is planned to be updated during the second phase of the W-314 Project to cover the second phase of the Project's scope. The objective is to provide requirement traceability by recording the analysis/basis for the functional descriptions of the master pump shutdown system. This document identifies the sources of the requirements and/or how these were derived. Each requirement is validated either by quoting the source or an analysis process involving the required functionality, performance characteristics, operationsmore » input or engineering judgment.« less

Montana Standards and Guidelines for Career and Vocational/Technical Education. Summer 2002 Update.

ERIC Educational Resources Information Center

Montana State Office of Public Instruction, Helena.

This document presents Montana's standards and guidelines for career and vocational/technical education (CVTE). The guide begins with a directory of Montana's key CVTE personnel and specialists. Part 1 presents the federal and state definitions of CVTE and provides an overview of Montana's system for delivering CVTE and its philosophy regarding…

Education Policy Implementation: A Literature Review and Proposed Framework. OECD Education Working Papers, No. 162

ERIC Educational Resources Information Center

Viennet, Romane; Pont, Beatriz

2017-01-01

This literature review focuses on education policy implementation, its definition, processes and determinants. It aims to clarify what implementing policies involve in complex education systems to support policy work, building on the literature and country examples. An introduction delves into the reasons behind the need to update the concept of…

Report of the IAU Working Group on cartographic coordinates and rotational elements: 2009

USGS Publications Warehouse

Archinal, B.A.; A'Hearn, M.F.; Bowell, E.; Conrad, A.; Consolmagno, G.J.; Courtin, R.; Fukushima, T.; Hestroffer, D.; Hilton, J.L.; Krasinsky, G.A.; Neumann, G.; Oberst, J.; Seidelmann, P.K.; Stooke, P.; Tholen, D.J.; Thomas, P.C.; Williams, I.P.

2010-01-01

Every three years the IAU Working Group on Cartographic Coordinates and Rotational Elements revises tables giving the directions of the poles of rotation and the prime meridians of the planets, satellites, minor planets, and comets. This report takes into account the IAU Working Group for Planetary System Nomenclature (WGPSN) and the IAU Committee on Small Body Nomenclature (CSBN) definition of dwarf planets, introduces improved values for the pole and rotation rate of Mercury, returns the rotation rate of Jupiter to a previous value, introduces improved values for the rotation of five satellites of Saturn, and adds the equatorial radius of the Sun for comparison. It also adds or updates size and shape information for the Earth, Mars’ satellites Deimos and Phobos, the four Galilean satellites of Jupiter, and 22 satellites of Saturn. Pole, rotation, and size information has been added for the asteroids (21) Lutetia, (511) Davida, and (2867) Šteins. Pole and rotation information has been added for (2) Pallas and (21) Lutetia. Pole and rotation and mean radius information has been added for (1) Ceres. Pole information has been updated for (4) Vesta. The high precision realization for the pole and rotation rate of the Moon is updated. Alternative orientation models for Mars, Jupiter, and Saturn are noted. The Working Group also reaffirms that once an observable feature at a defined longitude is chosen, a longitude definition origin should not change except under unusual circumstances. It is also noted that alternative coordinate systems may exist for various (e.g. dynamical) purposes, but specific cartographic coordinate system information continues to be recommended for each body. The Working Group elaborates on its purpose, and also announces its plans to occasionally provide limited updates to its recommendations via its website, in order to address community needs for some updates more often than every 3 years. Brief recommendations are also made to the general planetary community regarding the need for controlled products, and improved or consensus rotation models for Mars, Jupiter, and Saturn.

Report of the IAU Working Group on cartographic coordinates and rotational elements: 2009

USGS Publications Warehouse

Archinal, Brent A.; A’Hearn, Michael F.; Bowell, Edward; Conrad, Al; Consolmagno, Guy J.; Courtin, Regis; Fukushima, Toshio; Hestroffer, Daniel; Hilton, James L.; Krasinsky, Georgij A.; Neumann, Gregory; Oberst, Jurgen; Seidelmann, P. Kenneth; Stooke, Philip; Tholen, David J.; Thomas, Peter C.; Williams, Iwan P.

2010-01-01

Every three years the IAU Working Group on Cartographic Coordinates and Rotational Elements revises tables giving the directions of the poles of rotation and the prime meridians of the planets, satellites, minor planets, and comets. This report takes into account the IAU Working Group for Planetary System Nomenclature (WGPSN) and the IAU Committee on Small Body Nomenclature (CSBN) definition of dwarf planets, introduces improved values for the pole and rotation rate of Mercury, returns the rotation rate of Jupiter to a previous value, introduces improved values for the rotation of five satellites of Saturn, and adds the equatorial radius of the Sun for comparison. It also adds or updates size and shape information for the Earth, Mars’ satellites Deimos and Phobos, the four Galilean satellites of Jupiter, and 22 satellites of Saturn. Pole, rotation, and size information has been added for the asteroids (21) Lutetia, (511) Davida, and (2867) Šteins. Pole and rotation information has been added for (2) Pallas and (21) Lutetia. Pole and rotation and mean radius information has been added for (1) Ceres. Pole information has been updated for (4) Vesta. The high precision realization for the pole and rotation rate of the Moon is updated. Alternative orientation models for Mars, Jupiter, and Saturn are noted. The Working Group also reaffirms that once an observable feature at a defined longitude is chosen, a longitude definition origin should not change except under unusual circumstances. It is also noted that alternative coordinate systems may exist for various (e.g. dynamical) purposes, but specific cartographic coordinate system information continues to be recommended for each body. The Working Group elaborates on its purpose, and also announces its plans to occasionally provide limited updates to its recommendations via its website, in order to address community needs for some updates more often than every 3 years. Brief recommendations are also made to the general planetary community regarding the need for controlled products, and improved or consensus rotation models for Mars, Jupiter, and Saturn.

Distributed Synchronization in Networks of Agent Systems With Nonlinearities and Random Switchings.

PubMed

Tang, Yang; Gao, Huijun; Zou, Wei; Kurths, Jürgen

2013-02-01

In this paper, the distributed synchronization problem of networks of agent systems with controllers and nonlinearities subject to Bernoulli switchings is investigated. Controllers and adaptive updating laws injected in each vertex of networks depend on the state information of its neighborhood. Three sets of Bernoulli stochastic variables are introduced to describe the occurrence probabilities of distributed adaptive controllers, updating laws and nonlinearities, respectively. By the Lyapunov functions method, we show that the distributed synchronization of networks composed of agent systems with multiple randomly occurring nonlinearities, multiple randomly occurring controllers, and multiple randomly occurring updating laws can be achieved in mean square under certain criteria. The conditions derived in this paper can be solved by semi-definite programming. Moreover, by mathematical analysis, we find that the coupling strength, the probabilities of the Bernoulli stochastic variables, and the form of nonlinearities have great impacts on the convergence speed and the terminal control strength. The synchronization criteria and the observed phenomena are demonstrated by several numerical simulation examples. In addition, the advantage of distributed adaptive controllers over conventional adaptive controllers is illustrated.

System analysis study of space platform and station accommodations for life sciences research facilities. Volume 2: Study results, attachment 2. Phase A: Conceptual design and programmatics

NASA Technical Reports Server (NTRS)

Wiley, Lowell F.

1985-01-01

The study results from the conceptual design and programmatics segment of the Space Platform and Station Accommodation for Life Sciences Research Facilities. The results and significant findings of the conceptual design and programmatics were generated by these tasks: (1) the review and update engineering and science requirements; (2) analysis of life sciences mission transition scenario; (3) the review and update of key trade issues; (4) the development of conceptual definition and designs; and (5) the development of the work breakdown schedule and its dictionary, program schedule, and estimated costs.

Stepping stones towards a new prokaryotic taxonomy.

PubMed

Gevers, Dirk; Dawyndt, Peter; Vandamme, Peter; Willems, Anne; Vancanneyt, Marc; Swings, Jean; De Vos, Paul

2006-11-29

Technological developments provide new insights into prokaryotic evolution and diversity and provoke a continuous need to update taxonomy and revise classification schemes. Our present species concept and definition are being challenged by the growing amount of whole genomic information, which should allow improvements in the natural species definition. The continuous quest for an objective and stable method for sorting strains into coherent homogeneous groups is inherent to prokaryotic systematics and nomenclature. Morphological, biochemical, physiological, phenotypic and chemotaxonomic criteria have been complemented by molecular data and pragmatic, purpose built, species definitions are being replaced by more natural ones based on evolutionary insights. It is imperative to give due consideration to both fundamental and applied aspects of future species concepts and definitions. The present paper discusses the present practice in prokaryotic taxonomy of how this system developed and how it may evolve in the future.

A practical implementation for a data dictionary in an environment of diverse data sets

USGS Publications Warehouse

Sprenger, Karla K.; Larsen, Dana M.

1993-01-01

The need for a data dictionary database at the U.S. Geological Survey's EROS Data Center (EDC) was reinforced with the Earth Observing System Data and Information System (EOSDIS) requirement for consistent field definitions of data sets residing at more than one archive center. The EDC requirement addresses the existence of multiple sets with identical field definitions using various naming conventions. The EDC is developing a data dictionary database to accomplish the following foals: to standardize field names for ease in software development; to facilitate querying and updating of the date; and to generate ad hoc reports. The structure of the EDC electronic data dictionary database supports different metadata systems as well as many different data sets. A series of reports is used to keep consistency among data sets and various metadata systems.

Crystal Growth of ZnSe and Related Ternary Compound Semiconductors by Physical Vapor Transport

NASA Technical Reports Server (NTRS)

Cushman, Paula P.

1997-01-01

Preliminary definition of all of the necessary materials, labor, services, and facilities necessary to provide science requirement definition, initiate hardware development activities, and provide an update flight program proposal consistent with the NRA selection letter. The major tasks identified in this SOW are in the general category of science requirements determination, instrument definition, and updated flight program proposal. The Contractor shall define preliminary management, technical and integration requirements for the program, including improved cost/schedule estimates. The Contractor shall identify new technology requirements, define experiment accommodations and operational requirements and negotiate procurement of any long lead items, if required, with the government.

Crystal Growth of ZnSe and Related Ternary Compound Semiconductors by Physical Vapor Transport

NASA Technical Reports Server (NTRS)

Su, Ching-Hua

1997-01-01

Preliminary definition of all of the necessary materials, labor, services, and facilities necessary to provide science requirement definition, initiate hardware development activities, and provide an updated flight program proposal consistent with the NRA selection letter. The major tasks identified in this SOW are in the general category of science requirements determination, instrument definition, and updated flight program proposal. The Contractor shall define preliminary management, technical and integration requirements for the program, including improved cost/schedule estimates. The Contractor shall identify new technology requirements, define experiment accommodations and operational requirements and negotiate procurement of any long lead items, if required, with the government.

Requirements Analysis Study for Master Pump Shutdown System Project Development Specification [SEC 1 and 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

BEVINS, R.R.

This study is a requirements document that presents analysis for the functional description for the master pump shutdown system. This document identifies the sources of the requirements and/or how these were derived. Each requirement is validated either by quoting the source or an analysis process involving the required functionality, performance characteristics, operations input or engineering judgment. The requirements in this study apply to the first phase of the W314 Project. This document has been updated during the definitive design portion of the first phase of the W314 Project to capture additional software requirements and is planned to be updated duringmore » the second phase of the W314 Project to cover the second phase of the project's scope.« less

Rhizome-Modular Teaching of Students as a Basis of Their Professional Creative Self-Consciousness Formation

ERIC Educational Resources Information Center

Bystritskaya, Elena V.; Burkhanova, Irina Y.; Voronin, Denis I.; Ivanova, Svetlana S.; Grigoryeva, Elena L.

2016-01-01

The relevance of the study is determined by a necessity to ensure contents unity of two professional education degrees: Bachelor's and Master's. The necessity to update higher professional education originates from the crisis of educational system state which is confirmed in theory and in practice. The purpose of the study is in definition of…

Medicare program; End-Stage Renal Disease prospective payment system, quality incentive program, and Durable Medical Equipment, Prosthetics, Orthotics, and Supplies. Final rule.

PubMed

2014-11-06

This final rule will update and make revisions to the End-Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2015. This rule also finalizes requirements for the ESRD quality incentive program (QIP), including for payment years (PYs) 2017 and 2018. This rule will also make a technical correction to remove outdated terms and definitions. In addition, this final rule sets forth the methodology for adjusting Durable Medical Equipment, Prosthetics, Orthotics, and Supplies (DMEPOS) fee schedule payment amounts using information from the Medicare DMEPOS Competitive Bidding Program (CBP); makes alternative payment rules for certain DME under the Medicare DMEPOS CBP; clarifies the statutory Medicare hearing aid coverage exclusion and specifies devices not subject to the hearing aid exclusion; will not update the definition of minimal self-adjustment; clarifies the Change of Ownership (CHOW) and provides for an exception to the current requirements; revises the appeal provisions for termination of a CBP contract, including the beneficiary notification requirement under the Medicare DMEPOS CBP, and makes a technical change to the regulation related to the conditions for awarding contracts for furnishing infusion drugs under the Medicare DMEPOS CBP.

Emergency department performance measures updates: proceedings of the 2014 emergency department benchmarking alliance consensus summit.

PubMed

Wiler, Jennifer L; Welch, Shari; Pines, Jesse; Schuur, Jeremiah; Jouriles, Nick; Stone-Griffith, Suzanne

2015-05-01

The objective was to review and update key definitions and metrics for emergency department (ED) performance and operations. Forty-five emergency medicine leaders convened for the Third Performance Measures and Benchmarking Summit held in Las Vegas, February 21-22, 2014. Prior to arrival, attendees were assigned to workgroups to review, revise, and update the definitions and vocabulary being used to communicate about ED performance and operations. They were provided with the prior definitions of those consensus summits that were published in 2006 and 2010. Other published definitions from key stakeholders in emergency medicine and health care were also reviewed and circulated. At the summit, key terminology and metrics were discussed and debated. Workgroups communicated online, via teleconference, and finally in a face-to-face meeting to reach consensus regarding their recommendations. Recommendations were then posted and open to a 30-day comment period. Participants then reanalyzed the recommendations, and modifications were made based on consensus. A comprehensive dictionary of ED terminology related to ED performance and operation was developed. This article includes definitions of operating characteristics and internal and external factors relevant to the stratification and categorization of EDs. Time stamps, time intervals, and measures of utilization were defined. Definitions of processes and staffing measures are also presented. Definitions were harmonized with performance measures put forth by the Centers for Medicare and Medicaid Services (CMS) for consistency. Standardized definitions are necessary to improve the comparability of EDs nationally for operations research and practice. More importantly, clear precise definitions describing ED operations are needed for incentive-based pay-for-performance models like those developed by CMS. This document provides a common language for front-line practitioners, managers, health policymakers, and researchers. © 2015 by the Society for Academic Emergency Medicine.

Report of the IAU Working Group on Cartographic Coordinates and Rotational Elements: 2015

NASA Astrophysics Data System (ADS)

Archinal, B. A.; Acton, C. H.; A'Hearn, M. F.; Conrad, A.; Consolmagno, G. J.; Duxbury, T.; Hestroffer, D.; Hilton, J. L.; Kirk, R. L.; Klioner, S. A.; McCarthy, D.; Meech, K.; Oberst, J.; Ping, J.; Seidelmann, P. K.; Tholen, D. J.; Thomas, P. C.; Williams, I. P.

2018-03-01

This report continues the practice where the IAU Working Group on Cartographic Coordinates and Rotational Elements revises recommendations regarding those topics for the planets, satellites, minor planets, and comets approximately every 3 years. The Working Group has now become a "functional working group" of the IAU, and its membership is open to anyone interested in participating. We describe the procedure for submitting questions about the recommendations given here or the application of these recommendations for creating a new or updated coordinate system for a given body. Regarding body orientation, the following bodies have been updated: Mercury, based on MESSENGER results; Mars, along with a refined longitude definition; Phobos; Deimos; (1) Ceres; (52) Europa; (243) Ida; (2867) Šteins; Neptune; (134340) Pluto and its satellite Charon; comets 9P/Tempel 1, 19P/Borrelly, 67P/Churyumov-Gerasimenko, and 103P/Hartley 2, noting that such information is valid only between specific epochs. The special challenges related to mapping 67P/Churyumov-Gerasimenko are also discussed. Approximate expressions for the Earth have been removed in order to avoid confusion, and the low precision series expression for the Moon's orientation has been removed. The previously online only recommended orientation model for (4) Vesta is repeated with an explanation of how it was updated. Regarding body shape, text has been included to explain the expected uses of such information, and the relevance of the cited uncertainty information. The size of the Sun has been updated, and notation added that the size and the ellipsoidal axes for the Earth and Jupiter have been recommended by an IAU Resolution. The distinction of a reference radius for a body (here, the Moon and Titan) is made between cartographic uses, and for orthoprojection and geophysical uses. The recommended radius for Mercury has been updated based on MESSENGER results. The recommended radius for Titan is returned to its previous value. Size information has been updated for 13 other Saturnian satellites and added for Aegaeon. The sizes of Pluto and Charon have been updated. Size information has been updated for (1) Ceres and given for (16) Psyche and (52) Europa. The size of (25143) Itokawa has been corrected. In addition, the discussion of terminology for the poles (hemispheres) of small bodies has been modified and a discussion on cardinal directions added. Although they continue to be used for planets and their satellites, it is assumed that the planetographic and planetocentric coordinate system definitions do not apply to small bodies. However, planetocentric and planetodetic latitudes and longitudes may be used on such bodies, following the right-hand rule. We repeat our previous recommendations that planning and efforts be made to make controlled cartographic products; newly recommend that common formulations should be used for orientation and size; continue to recommend that a community consensus be developed for the orientation models of Jupiter and Saturn; newly recommend that historical summaries of the coordinate systems for given bodies should be developed, and point out that for planets and satellites planetographic systems have generally been historically preferred over planetocentric systems, and that in cases when planetographic coordinates have been widely used in the past, there is no obvious advantage to switching to the use of planetocentric coordinates. The Working Group also requests community input on the question submitting process, posting of updates to the Working Group website, and on whether recommendations should be made regarding exoplanet coordinate systems.

7 CFR 3430.602 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Beginning Farmer and Rancher Development Program § 3430.602 Definitions. The definitions applicable to the... 2002 Prices Paid by Farmer Index compiled and updated annually by the USDA National Agricultural... as determined by the U.S. Department of Health and Human Services (DHHS), using the Census Poverty...

Characteristics of Hydrogen Monitoring Systems for Severe Accident Management at a Nuclear Power Plant

NASA Astrophysics Data System (ADS)

Petrosyan, V. G.; Yeghoyan, E. A.; Grigoryan, A. D.; Petrosyan, A. P.; Movsisyan, M. R.

2018-02-01

One of the main objectives of severe accident management at a nuclear power plant is to protect the integrity of the containment, for which the most serious threat is possible ignition of the generated hydrogen. There should be a monitoring system providing information support of NPP personnel, ensuring data on the current state of a containment gaseous environment and trends in its composition changes. Monitoring systems' requisite characteristics definition issues are considered by the example of a particular power unit. Major characteristics important for proper information support are discussed. Some features of progression of severe accident scenarios at considered power unit are described and a possible influence of the hydrogen concentration monitoring system performance on the information support reliability in a severe accident is analyzed. The analysis results show that the following technical characteristics of the combustible gas monitoring systems are important for the proper information support of NPP personnel in the event of a severe accident at a nuclear power plant: measured parameters, measuring ranges and errors, update rate, minimum detectable concentration of combustible gas, monitoring reference points, environmental qualification parameters of the system components. For NPP power units with WWER-440/270 (230) type reactors, which have a relatively small containment volume, the update period for measurement results is a critical characteristic of the containment combustible gas monitoring system, and the choice of monitoring reference points should be focused not so much on the definition of places of possible hydrogen pockets but rather on the definition of places of a possible combustible mixture formation. It may be necessary for the above-mentioned power units to include in the emergency operating procedures measures aimed at a timely heat removal reduction from the containment environment if there are signs of a severe accident phase approaching to prevent a combustible mixture formation in the containment.

47 CFR 90.1023 - Records maintenance and definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Records maintenance and definitions. 90.1023....1023 Records maintenance and definitions. (a) Records maintenance. All winning bidders qualifying as small or very small businesses shall maintain at their principal place of business an updated file of...

47 CFR 90.815 - Records maintenance and definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Records maintenance and definitions. 90.815... Radio Service § 90.815 Records maintenance and definitions. (a) Records maintenance. All winning bidders qualifying as small businesses, shall maintain at their principal place of business an updated file of...

Computer-assisted expert case definition in electronic health records.

PubMed

Walker, Alexander M; Zhou, Xiaofeng; Ananthakrishnan, Ashwin N; Weiss, Lisa S; Shen, Rongjun; Sobel, Rachel E; Bate, Andrew; Reynolds, Robert F

2016-02-01

To describe how computer-assisted presentation of case data can lead experts to infer machine-implementable rules for case definition in electronic health records. As an illustration the technique has been applied to obtain a definition of acute liver dysfunction (ALD) in persons with inflammatory bowel disease (IBD). The technique consists of repeatedly sampling new batches of case candidates from an enriched pool of persons meeting presumed minimal inclusion criteria, classifying the candidates by a machine-implementable candidate rule and by a human expert, and then updating the rule so that it captures new distinctions introduced by the expert. Iteration continues until an update results in an acceptably small number of changes to form a final case definition. The technique was applied to structured data and terms derived by natural language processing from text records in 29,336 adults with IBD. Over three rounds the technique led to rules with increasing predictive value, as the experts identified exceptions, and increasing sensitivity, as the experts identified missing inclusion criteria. In the final rule inclusion and exclusion terms were often keyed to an ALD onset date. When compared against clinical review in an independent test round, the derived final case definition had a sensitivity of 92% and a positive predictive value of 79%. An iterative technique of machine-supported expert review can yield a case definition that accommodates available data, incorporates pre-existing medical knowledge, is transparent and is open to continuous improvement. The expert updates to rules may be informative in themselves. In this limited setting, the final case definition for ALD performed better than previous, published attempts using expert definitions. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Factors to improve the interobserver agreement for gastric atrophy and intestinal metaplasia: consensus of definition and criteria.

PubMed

Kim, Sung Sun; Kook, Myeong-Cherl; Shin, Ok-Ran; Kim, Hee Sung; Bae, Han-Ik; Seo, An Na; Park, Do Youn; Choi, Il Ju; Kim, Young-Il; Nam, Byung Ho; Kim, Sohee

2018-04-01

Intestinal metaplasia and atrophy of the gastric mucosa are associated with Helicobacter pylori infection and are considered premalignant lesions. The updated Sydney system is used for these parameters, but experienced pathologists and consensus processes are required for interobserver agreement. We sought to determine the influence of the consensus process on the assessment of intestinal metaplasia and atrophy. Two study sets were used: consensus and validation. The consensus set was circulated and five gastrointestinal pathologists evaluated them independently using the updated Sydney system. The consensus of the definitions was then determined at the first consensus meeting. The same set was recirculated to determine the effect of the consensus. The second consensus meeting was held to standardise the grading criteria and the validation set was circulated to determine the influence. Two additional circulations were performed to assess the maintainance of consensus and intraobserver variability. Interobserver agreement of intestinal metaplasia and atrophy was improved through the consensus process (intestinal metaplasia: baseline κ = 0.52 versus final κ = 0.68, P = 0.006; atrophy: baseline κ = 0.19 versus final κ = 0.43, P < 0.001). Higher interobserver agreement in atrophy was observed after consensus regarding the definition (pre-consensus: κ = 0.19 versus post-consensus: κ = 0.34, P = 0.001). There was improved interobserver agreement in intestinal metaplasia after standardisation of the grading criteria (pre-standardisation: κ = 0.56 versus post-standardisation: κ = 0.71, P = 0.010). This study suggests that interobserver variability regarding intestinal metaplasia and atrophy may result from lack of a precise definition and fine criteria, and can be reduced by consensus of definition and standardisation of grading criteria. © 2017 John Wiley & Sons Ltd.

Crispen's Five Antivirus Rules.

ERIC Educational Resources Information Center

Crispen, Patrick Douglas

2000-01-01

Provides rules for protecting computers from viruses, Trojan horses, or worms. Topics include purchasing commercial antivirus programs and keeping them updated; updating virus definitions weekly; precautions before opening attached files; macro virus protection in Microsoft Word; and precautions with executable files. (LRW)

VCE testbed program planning and definition study

NASA Technical Reports Server (NTRS)

Westmoreland, J. S.; Godston, J.

1978-01-01

The flight definition of the Variable Stream Control Engine (VSCE) was updated to reflect design improvements in the two key components: (1) the low emissions duct burner, and (2) the coannular exhaust nozzle. The testbed design was defined and plans for the overall program were formulated. The effect of these improvements was evaluated for performance, emissions, noise, weight, and length. For experimental large scale testing of the duct burner and coannular nozzle, a design definition of the VCE testbed configuration was made. This included selecting the core engine, determining instrumentation requirements, and selecting the test facilities, in addition to defining control system and assembly requirements. Plans for a comprehensive test program to demonstrate the duct burner and nozzle technologies were formulated. The plans include both aeroacoustic and emissions testing.

Astronomy sortie missions definition study. Volume 2, book 2: Appendix

NASA Technical Reports Server (NTRS)

1972-01-01

An updated and coordinated baseline experiment definition document is presented for each of the candidate astronomy sortie mission telescopes and arrays. The experiment objectives, requirements, interfaces, timelines, and programmatic considerations are included.

75 FR 67201 - Flightcrew Alerting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... airplanes concerning flightcrew alerting. These standards update definitions, prioritization, color... addressed regulations regarding definitions, prioritization, color requirements, and performance for... proposal: Reserving and limiting the use of alerting colors red, amber, or yellow on the flight deck...

Approximating Fluid Flow from Ambient to Very Low Pressures: Modeling ISS Experiments that Vent to Vacuum

NASA Technical Reports Server (NTRS)

Minor, Robert

2002-01-01

Two ISS (International Space Station) experiment payloads will vent a volume of gas overboard via either the ISS Vacuum Exhaust System or the Vacuum Resource System. A system of ducts, valves and sensors, under design, will connect the experiments to the ISS systems. The following tasks are required: Create an analysis tool that will verify the rack vacuum system design with respect to design requirements, more specifically approximate pressure at given locations within the vacuum systems; Determine the vent duration required to achieve desired pressure within the experiment modules; Update the analysis as systems and operations definitions mature.

Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update

PubMed Central

Graham, Stephen M.; Cuevas, Luis E.; Jean-Philippe, Patrick; Browning, Renee; Casenghi, Martina; Detjen, Anne K.; Gnanashanmugam, Devasena; Hesseling, Anneke C.; Kampmann, Beate; Mandalakas, Anna; Marais, Ben J.; Schito, Marco; Spiegel, Hans M. L.; Starke, Jeffrey R.; Worrell, Carol; Zar, Heather J.

2015-01-01

Consensus case definitions for childhood tuberculosis have been proposed by an international expert panel, aiming to standardize the reporting of cases in research focusing on the diagnosis of intrathoracic tuberculosis in children. These definitions are intended for tuberculosis diagnostic evaluation studies of symptomatic children with clinical suspicion of intrathoracic tuberculosis, and were not intended to predefine inclusion criteria into such studies. Feedback from researchers suggested that further clarification was required and that these case definitions could be further improved. Particular concerns were the perceived complexity and overlap of some case definitions, as well as the potential exclusion of children with acute onset of symptoms or less severe disease. The updated case definitions proposed here incorporate a number of key changes that aim to reduce complexity and improve research performance, while maintaining the original focus on symptomatic children suspected of having intrathoracic tuberculosis. The changes proposed should enhance harmonized classification for intrathoracic tuberculosis disease in children across studies, resulting in greater comparability and the much-needed ability to pool study results. PMID:26409281

Planetary Protection and Mars Special Regions--A Suggestion for Updating the Definition.

PubMed

Rettberg, Petra; Anesio, Alexandre M; Baker, Victor R; Baross, John A; Cady, Sherry L; Detsis, Emmanouil; Foreman, Christine M; Hauber, Ernst; Ori, Gian Gabriele; Pearce, David A; Renno, Nilton O; Ruvkun, Gary; Sattler, Birgit; Saunders, Mark P; Smith, David H; Wagner, Dirk; Westall, Frances

2016-02-01

We highlight the role of COSPAR and the scientific community in defining and updating the framework of planetary protection. Specifically, we focus on Mars "Special Regions," areas where strict planetary protection measures have to be applied before a spacecraft can explore them, given the existence of environmental conditions that may be conducive to terrestrial microbial growth. We outline the history of the concept of Special Regions and inform on recent developments regarding the COSPAR policy, namely, the MEPAG SR-SAG2 review and the Academies and ESF joint committee report on Mars Special Regions. We present some new issues that necessitate the update of the current policy and provide suggestions for new definitions of Special Regions. We conclude with the current major scientific questions that remain unanswered regarding Mars Special Regions.

76 FR 35481 - NASA Advisory Council; Science Committee; Astrophysics Subcommittee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... Update. --Research and Analysis Update. --Wide-Field Infrared Survey Telescope Science Definition Team... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 11-054] NASA Advisory Council; Science... Subcommittee of the NASA Advisory Council (NAC). This subcommittee reports to the Science Committee of the NAC...

The neural basis of reversal learning: An updated perspective

PubMed Central

Izquierdo, Alicia; Brigman, Jonathan L.; Radke, Anna K.; Rudebeck, Peter H.; Holmes, Andrew

2016-01-01

Reversal learning paradigms are among the most widely used tests of cognitive flexibility and have been used as assays, across species, for altered cognitive processes in a host of neuropsychiatric conditions. Based on recent studies in humans, non-human primates, and rodents, the notion that reversal learning tasks primarily measure response inhibition, has been revised. In this review, we describe how cognitive flexibility is measured by reversal learning and discuss new definitions of the construct validity of the task that are serving as an heuristic to guide future research in this field. We also provide an update on the available evidence implicating certain cortical and subcortical brain regions in the mediation of reversal learning, and an overview of the principle neurotransmitter systems involved. PMID:26979052

Censorship in Massachusetts: An Update.

ERIC Educational Resources Information Center

Woods, L. B.; O'Brien, Jane E.

This report updates a 1979 article from the Bay State Librarian about censorship in Massachusetts libraries from 1966 through 1975. Compiled using data from the American Library Association's Office of Intellectual Freedom (OIF), the report provides information about censorship attempts and actions between 1976 and 1982. The definition of…

Acute exacerbation of idiopathic pulmonary fibrosis triggered by Aspergillus empyema.

PubMed

Suzuki, Atsushi; Kimura, Tomoki; Kataoka, Kensuke; Matsuda, Toshiaki; Yokoyama, Toshiki; Mori, Yuta; Kondoh, Yasuhiro

2018-01-01

Acute exacerbation (AE) is a severe and life-threatening complication of idiopathic pulmonary fibrosis (IPF). In 2016, the definition and diagnostic criteria for AE-IPF were updated by an international working group. The new definition includes any acute, clinically significant respiratory deterioration (both idiopathic and triggered events) characterized by evidence of new widespread alveolar abnormality in patients with IPF. There are no currently proven beneficial management strategies for idiopathic and triggered AE-IPF. This is the first report describing AE-IPF triggered by Aspergillus empyema, which was improved by a combination of corticosteroid, systemic antifungal therapy, local antifungal therapy, and additional pharmacological therapies. Future research may reveal optimal strategies for both idiopathic and triggered AE-IPF.

Experiment definition phase shuttle laboratory. LDRL-10.6 experiment

NASA Technical Reports Server (NTRS)

1976-01-01

The work completed on the experiment definition phase of the shuttle laboratory LDRL 10.6 micrometers experiment from 27 September 1975 to 26 January 1976 was reported. This work included progress in the following areas: (1) optomechanical system: completion of detail drawings, completion of the beryllium subassembly, fabrication, checking, and weighing of approximately 95% of the detailed parts, dry film lubrication of the bearings and gears, and initiation of assembly of the gimbals; (2) optics: update of the detailed optical layout, receipt of nine mirrors and the pre-expander; (3) miscellaneous: delivery of draft material for the final report, completion of optical testing of the 10.6 micrometers receiver, and receipt, assembly, and checkout of NASA test console.

76 FR 38992 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Update to Materials...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... Definitions 5/24/10 12/28/10, 75 FR 81555... Addition of four new definitions: Exterior panels, interior panels, flat wood panel coating, and tileboard. See Part III of the IBR document. * * * * * * Part E...

The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision.

PubMed

Magerl, M; Altrichter, S; Borzova, E; Giménez-Arnau, A; Grattan, C E H; Lawlor, F; Mathelier-Fusade, P; Meshkova, R Y; Zuberbier, T; Metz, M; Maurer, M

2016-06-01

These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (Allergy, 2009). The aim of these recommendations is to improve the diagnosis and management of patients with CIndU. Our recommendations acknowledge the latest changes in our understanding of CIndU, and the available therapeutic options, as well as the development of novel diagnostic tools. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

42 CFR 424.502 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... granted the legal authority to enroll it in the Medicare program, to make changes or updates to the... updates to the enrollment record. The delegated official must be an individual with ownership or control... felony offense (as defined in § 424.535(a)(3)(i)) within the last 10 years preceding enrollment...

42 CFR 424.502 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... legal authority to enroll it in the Medicare program, to make changes or updates to the organization's... updates to the enrollment record. The delegated official must be an individual with ownership or control... felony offense (as defined in § 424.535(a)(3)(i)) within the last 10 years preceding enrollment...

42 CFR 424.502 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... granted the legal authority to enroll it in the Medicare program, to make changes or updates to the... updates to the enrollment record. The delegated official must be an individual with ownership or control... felony offense (as defined in § 424.535(a)(3)(i)) within the last 10 years preceding enrollment...

42 CFR 424.502 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... granted the legal authority to enroll it in the Medicare program, to make changes or updates to the... updates to the enrollment record. The delegated official must be an individual with ownership or control... felony offense (as defined in § 424.535(a)(3)(i)) within the last 10 years preceding enrollment...

Wind turbine reliability database update.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peters, Valerie A.; Hill, Roger Ray; Stinebaugh, Jennifer A.

2009-03-01

This report documents the status of the Sandia National Laboratories' Wind Plant Reliability Database. Included in this report are updates on the form and contents of the Database, which stems from a fivestep process of data partnerships, data definition and transfer, data formatting and normalization, analysis, and reporting. Selected observations are also reported.

The LUVOIR Mission Concept: Update and Technology Overview

NASA Technical Reports Server (NTRS)

Bolcar, Matthew R.

2016-01-01

We present an overview of the Large Ultra Violet Optical Infrared (LUVOIR) decadal mission concept study. We provide updates from recent activities of the Science and Technology Definition Team (STDT) and the Technology Working Group (TWG). We review the technology prioritization and discuss specific technology needs to enable the LUVOIR mission.

Tracing Assessment Practice as Reflected in "Assessment Update." NILOA Occasional Paper #28

ERIC Educational Resources Information Center

Banta, Trudy W.; Ewell, Peter T.; Cogswell, Cynthia A.

2016-01-01

At some future point, when a definitive history of the assessment movement is written, one of the most frequently cited, influential publications will be "Assessment Update" ("AU"). Since 1989, this bimonthly newsletter has been published by Jossey-Bass in partnership with Indiana University-Purdue University Indianapolis…

40 CFR 710.23 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... CHEMICAL INVENTORY REGULATIONS 2002 Inventory Update Reporting § 710.23 Definitions. In addition to the... part. Master Inventory File means EPA's comprehensive list of chemical substances which constitute the Chemical Substances Inventory compiled under section 8(b) of the Act. It includes substances reported under...

Kinetic energy definition in velocity Verlet integration for accurate pressure evaluation

NASA Astrophysics Data System (ADS)

Jung, Jaewoon; Kobayashi, Chigusa; Sugita, Yuji

2018-04-01

In molecular dynamics (MD) simulations, a proper definition of kinetic energy is essential for controlling pressure as well as temperature in the isothermal-isobaric condition. The virial theorem provides an equation that connects the average kinetic energy with the product of particle coordinate and force. In this paper, we show that the theorem is satisfied in MD simulations with a larger time step and holonomic constraints of bonds, only when a proper definition of kinetic energy is used. We provide a novel definition of kinetic energy, which is calculated from velocities at the half-time steps (t - Δt/2 and t + Δt/2) in the velocity Verlet integration method. MD simulations of a 1,2-dispalmitoyl-sn-phosphatidylcholine (DPPC) lipid bilayer and a water box using the kinetic energy definition could reproduce the physical properties in the isothermal-isobaric condition properly. We also develop a multiple time step (MTS) integration scheme with the kinetic energy definition. MD simulations with the MTS integration for the DPPC and water box systems provided the same quantities as the velocity Verlet integration method, even when the thermostat and barostat are updated less frequently.

Kinetic energy definition in velocity Verlet integration for accurate pressure evaluation.

PubMed

Jung, Jaewoon; Kobayashi, Chigusa; Sugita, Yuji

2018-04-28

In molecular dynamics (MD) simulations, a proper definition of kinetic energy is essential for controlling pressure as well as temperature in the isothermal-isobaric condition. The virial theorem provides an equation that connects the average kinetic energy with the product of particle coordinate and force. In this paper, we show that the theorem is satisfied in MD simulations with a larger time step and holonomic constraints of bonds, only when a proper definition of kinetic energy is used. We provide a novel definition of kinetic energy, which is calculated from velocities at the half-time steps (t - Δt/2 and t + Δt/2) in the velocity Verlet integration method. MD simulations of a 1,2-dispalmitoyl-sn-phosphatidylcholine (DPPC) lipid bilayer and a water box using the kinetic energy definition could reproduce the physical properties in the isothermal-isobaric condition properly. We also develop a multiple time step (MTS) integration scheme with the kinetic energy definition. MD simulations with the MTS integration for the DPPC and water box systems provided the same quantities as the velocity Verlet integration method, even when the thermostat and barostat are updated less frequently.

Updated research nosology for HIV-associated neurocognitive disorders

PubMed Central

Antinori, A.; Arendt, G.; Becker, J.T.; Brew, B.J.; Byrd, D.A.; Cherner, M.; Clifford, D.B.; Cinque, P.; Epstein, L.G.; Goodkin, K.; Gisslen, M.; Grant, I.; Heaton, R.K.; Joseph, J.; Marder, K.; Marra, C.M.; McArthur, J.C.; Nunn, M.; Price, R.W.; Pulliam, L.; Robertson, K.R.; Sacktor, N.; Valcour, V.; Wojna, V.E.

2015-01-01

In 1991, the AIDS Task Force of the American Academy of Neurology published nomenclature and research case definitions to guide the diagnosis of neurologic manifestations of HIV-1 infection. Now, 16 years later, the National Institute of Mental Health and the National Institute of Neurological Diseases and Stroke have charged a working group to critically review the adequacy and utility of these definitional criteria and to identify aspects that require updating. This report represents a majority view, and unanimity was not reached on all points. It reviews our collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities; and suggests inclusion of the term asymptomatic neurocognitive impairment to categorize individuals with subclinical impairment. An algorithm is proposed to assist in standardized diagnostic classification of HAND. PMID:17914061

Symmetric tridiagonal structure preserving finite element model updating problem for the quadratic model

NASA Astrophysics Data System (ADS)

Rakshit, Suman; Khare, Swanand R.; Datta, Biswa Nath

2018-07-01

One of the most important yet difficult aspect of the Finite Element Model Updating Problem is to preserve the finite element inherited structures in the updated model. Finite element matrices are in general symmetric, positive definite (or semi-definite) and banded (tridiagonal, diagonal, penta-diagonal, etc.). Though a large number of papers have been published in recent years on various aspects of solutions of this problem, papers dealing with structure preservation almost do not exist. A novel optimization based approach that preserves the symmetric tridiagonal structures of the stiffness and damping matrices is proposed in this paper. An analytical expression for the global minimum solution of the associated optimization problem along with the results of numerical experiments obtained by both the analytical expressions and by an appropriate numerical optimization algorithm are presented. The results of numerical experiments support the validity of the proposed method.

The Next-Generation Infrared Space Mission Spica: Project Updates

NASA Astrophysics Data System (ADS)

Nakagawa, Takao; Shibai, Hiroshi; Kaneda, Hidehiro; Kohno, Kotaro; Matsuhara, Hideo; Ogawa, Hiroyuki; Onaka, Takashi; Roelfsema, Peter; SPICA Team

2017-03-01

We present project updates of the next-generation infrared space mission SPICA (Space Infrared Telescope for Cosmology and Astrophysics) as of November 2015. SPICA is optimized for mid- and far-infrared astronomy with unprecedented sensitivity, which will be achieved with a cryogenically cooled (below 8 K), large (2.5~m) telescope. SPICA is expected to address a number of key questions in various fields of astrophysics, ranging from studies of the star-formation history in the universe to the formation and evolution of planetary systems. The international collaboration framework of SPICA has been revisited. SPICA under the new framework passed the Mission Definition Review by JAXA in 2015. A proposal under the new framework to ESA is being prepared. The target launch year in the new framework is 2027/28.

20th Annual Systems Engineering Conference. Volume 2, Wednesday

DTIC Science & Technology

2017-10-26

Assurance Center (JFAC) 2017 Update u Mr. Thomas Hurt, Department of Defense 4B1 Tr a c k 2 m il le r Education & Training 19813 Shaping the... J . C . S. P. (2002, September). Agile requirements definition: A view from requirements engineering. In Proceedings of the International Workshop on...Management 52.2 (2005): 199-212. Web. 4. R. J . Calantone, and C . A. Di Benedetto. "Performance and Time to Market: Accelerating Cycle Time with

Space Construction Experiment Definition Study (SCEDS), part 2. Volume 2: Study results

NASA Technical Reports Server (NTRS)

1982-01-01

The Space Construction Experiment (SCE) was defined for integration into the Space Shuttle. This included development of flight assignment data, revision and update of preliminary mission timelines and test plans, analysis of flight safety issues, and definition of ground operations scenarios. New requirements for the flight experiment and changes for a large space antenna feed mask test article were incorporated. The program plan and cost estimates were updated. Revised SCE structural dynamics characteristics were provided for simulation and analysis of experimental tests to define and verify control limits and interactions effects between the SCE and the Orbiter digital automatic pilot.

Design/cost tradeoff studies. Appendix A. Supporting analyses and tradeoffs, book 2. Earth Observatory Satellite system definition study (EOS)

NASA Technical Reports Server (NTRS)

1974-01-01

Attitude reference systems for use with the Earth Observatory Satellite (EOS) are described. The systems considered are fixed and gimbaled star trackers, star mappers, and digital sun sensors. Covariance analyses were performed to determine performance for the most promising candidate in low altitude and synchronous orbits. The performance of attitude estimators that employ gyroscopes which are periodically updated by a star sensor is established by a single axis covariance analysis. The other systems considered are: (1) the propulsion system design, (2) electric power and electrical integration, (3) thermal control, (4) ground data processing, and (5) the test plan and cost reduction aspects of observatory integration and test.

77 FR 75936 - Control of Communicable Diseases: Interstate; Scope and Definitions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... add more current medical terminology where appropriate. HHS/CDC has determined that this NPRM is... proposing to update the definitions for interstate quarantine regulations to reflect modern terminology and..., under section 70.1, to reflect modern terminology and plain language commonly used by private sector...

The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the OMERACT MRI in Arthritis Working Group.

PubMed

Østergaard, Mikkel; Peterfy, Charles G; Bird, Paul; Gandjbakhch, Frédérique; Glinatsi, Daniel; Eshed, Iris; Haavardsholm, Espen A; Lillegraven, Siri; Bøyesen, Pernille; Ejbjerg, Bo; Foltz, Violaine; Emery, Paul; Genant, Harry K; Conaghan, Philip G

2017-11-01

The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Updated 2016 RAMRIS recommendations and a research agenda were developed.

Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology.

PubMed

Cho, Hyong Jin; Skowera, Anna; Cleare, Anthony; Wessely, Simon

2006-01-01

Chronic fatigue syndrome is a controversial condition especially concerning its clinical definition and aetiopathogenesis. Most recent research progress has been made in phenomenology and pathophysiology and we focused our review on these two areas. The phenomenology research supports the notion of a discrete fatigue syndrome which can be distinguished from depression and anxiety. The current case definition, however, may need an improvement based on empirical data. Recent advances in understanding the pathophysiology of chronic fatigue syndrome continue to demonstrate the involvement of the central nervous system. Hyperserotonergic state and hypoactivity of the hypothalamic-pituitary-adrenal axis constitute other findings, but the question of whether these alterations are a cause or consequence of chronic fatigue syndrome still remains unanswered. Immune system involvement in the pathogenesis seems certain but the findings on the specific mechanisms are still inconsistent. Genetic studies provide some evidence of the syndrome being a partly genetic condition, but environmental effects seem to be still predominant and identification of specific genes is still at a very early stage. The recent findings suggest that further research is needed in improving the current case definition; investigating overlaps and boundaries among various functional somatic syndromes; answering the question of whether the pathophysiologic findings are a cause or consequence; and elucidating the involvement of the central nervous system, immune system and genetic factors.

The Weekly Fab Five: Things You Should Do Every Week To Keep Your Computer Running in Tip-Top Shape.

ERIC Educational Resources Information Center

Crispen, Patrick

2001-01-01

Describes five steps that school librarians should follow every week to keep their computers running at top efficiency. Explains how to update virus definitions; run Windows update; run ScanDisk to repair errors on the hard drive; run a disk defragmenter; and backup all data. (LRW)

Overview of the National Health Educator Competencies Update Project, 1998-2004

ERIC Educational Resources Information Center

Gilmore, Gary David; Olsen, Larry K.; Taub, Alyson; Connell, David

2005-01-01

The National Health Educator Competencies Update Project (CUP), conducted during 1998-2004, addressed what health educators currently do in practice, the degree to which the role definition of the entry-level health educator is still up-to-date, and the validation of advanced-level competencies. A 19-page questionnaire was sent to a representative…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foley, Brian T.; Leitner, Thomas; Paraskevis, Dimitrios

The International Committee for the Taxonomy and Nomenclature of Viruses does not rule on virus classifications below the species level. The definition of species for viruses cannot be clearly defined for all types of viruses. The complex and interesting epidemiology of Human Immunodeficiency Viruses demands a detailed and informative nomenclature system, while at the same time it presents challenges such that many of the rules need to be flexibly applied or modified over time. As a result, this review outlines the nomenclature system for primate lentiviruses and provides an update on new findings since the last review was written inmore » 2000.« less

Potential Misclassification of Urinary Tract-Related Bacteremia Upon Applying the 2015 Catheter-Associated Urinary Tract Infection Surveillance Definition From the National Healthcare Safety Network.

PubMed

Greene, M Todd; Ratz, David; Meddings, Jennifer; Fakih, Mohamad G; Saint, Sanjay

2016-04-01

The Centers for Disease Control and Prevention recently updated the surveillance definition of catheter-associated urinary tract infection to include only urine culture bacteria of at least 1 × 10(5) colony-forming units/mL. Our findings suggest that the new surveillance definition may fail to capture clinically meaningful catheter-associated urinary tract infections.

Update 2016: Considerations for Using Agile in DoD Acquisition

DTIC Science & Technology

2016-12-01

What Is Agile? 4 2.1 Agile Manifesto and Principles—A Brief History 4 2.2 A Practical Definition 6 2.3 Example Agile Method 6 2.4 Example Agile...5.8 Team Composition 45 5.9 Culture 46 6 Conclusion 48 Appendix A: Examples of Agile Methods 50 Appendix B: Common Objections to Agile 53...thank all those who have contributed to our knowledge of apply- ing “other than traditional” methods for software system acquisition and management over

Definition of Tire Properties Required for Landing System Analysis

NASA Technical Reports Server (NTRS)

Clark, S. K.; Dodge, R. N.; Luchini, J. R.

1978-01-01

The data bank constructed provided two basic advantages for the user of aircraft tire information. First, computerization of the data bank allowed mechanical property data to be stored, corrected, updated, and revised quickly and easily as more reliable tests and measurements were carried out. Secondly, the format of the book which can be printed from the computerized data bank can be easily adjusted to suit the needs of the users without the great expense normally associated with reprinting and editing books set by ordinary typography.

The New Sepsis Definitions: Implications for the Basic and Translational Research Communities.

PubMed

Coopersmith, Craig M; Deutschman, Clifford S

2017-03-01

New definitions of sepsis and septic shock were published in early 2016, updating old definitions that have not been revisited since 2001. These new definitions should profoundly affect sepsis research. In addition, these papers present clinical criteria for identifying infected patients who are highly likely to have or to develop sepsis or septic shock. In contrast to previous approaches, these new clinical criteria are evidence based. In this review, two of the authors of the new definitions detail the content of the papers and explore the implications for shock and sepsis researchers.

40 CFR 52.824 - Original identification of plan section.

Code of Federal Regulations, 2014 CFR

2014-07-01

... rules, “Iowa Administrative Code,” effective February 22, 1995. This revision approves new definitions... definition updates. (E) “Iowa Administrative Code,” section 567-31.1, effective February 22, 1995. This rule... Quality and replaced the Iowa air pollution control statute which appeared as Chapter 136B of the Code of...

40 CFR 52.824 - Original identification of plan section.

Code of Federal Regulations, 2011 CFR

2011-07-01

... rules, “Iowa Administrative Code,” effective February 22, 1995. This revision approves new definitions... definition updates. (E) “Iowa Administrative Code,” section 567-31.1, effective February 22, 1995. This rule... Quality and replaced the Iowa air pollution control statute which appeared as Chapter 136B of the Code of...

40 CFR 52.824 - Original identification of plan section.

Code of Federal Regulations, 2013 CFR

2013-07-01

... rules, “Iowa Administrative Code,” effective February 22, 1995. This revision approves new definitions... definition updates. (E) “Iowa Administrative Code,” section 567-31.1, effective February 22, 1995. This rule... Quality and replaced the Iowa air pollution control statute which appeared as Chapter 136B of the Code of...

40 CFR 52.824 - Original identification of plan section.

Code of Federal Regulations, 2012 CFR

2012-07-01

... rules, “Iowa Administrative Code,” effective February 22, 1995. This revision approves new definitions... definition updates. (E) “Iowa Administrative Code,” section 567-31.1, effective February 22, 1995. This rule... Quality and replaced the Iowa air pollution control statute which appeared as Chapter 136B of the Code of...

Stalking and Cyberstalking. Prevention Update

ERIC Educational Resources Information Center

Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2011

2011-01-01

According to the Stalking Resource Center (SRC), "While legal definitions of stalking vary from one jurisdiction to another, a good working definition of stalking is a course of conduct directed at a specific person that would cause a reasonable person to feel fear. Stalking is serious, often violent, and can escalate over time." "Model Campus…

40 CFR 710.43 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... CHEMICAL INVENTORY REGULATIONS Inventory Update Reporting for 2006 and Beyond § 710.43 Definitions. In... subpart C of this part: Commercial use means the use of a chemical substance or mixture in a commercial...). Consumer use means the use of a chemical substance that is directly, or as part of a mixture, sold to or...

Calling and Vocation at Work: Definitions and Prospects for Research and Practice

ERIC Educational Resources Information Center

Dik, Bryan J.; Duffy, Ryan D.

2009-01-01

The purpose of this article is to initiate an effort to establish the constructs calling and vocation within counseling psychology. First, updated definitions of calling and vocation, developed with an eye toward stimulating research and providing useful practice applications, are proposed. Next, the authors explain how the constructs apply to the…

Tensor Dictionary Learning for Positive Definite Matrices.

PubMed

Sivalingam, Ravishankar; Boley, Daniel; Morellas, Vassilios; Papanikolopoulos, Nikolaos

2015-11-01

Sparse models have proven to be extremely successful in image processing and computer vision. However, a majority of the effort has been focused on sparse representation of vectors and low-rank models for general matrices. The success of sparse modeling, along with popularity of region covariances, has inspired the development of sparse coding approaches for these positive definite descriptors. While in earlier work, the dictionary was formed from all, or a random subset of, the training signals, it is clearly advantageous to learn a concise dictionary from the entire training set. In this paper, we propose a novel approach for dictionary learning over positive definite matrices. The dictionary is learned by alternating minimization between sparse coding and dictionary update stages, and different atom update methods are described. A discriminative version of the dictionary learning approach is also proposed, which simultaneously learns dictionaries for different classes in classification or clustering. Experimental results demonstrate the advantage of learning dictionaries from data both from reconstruction and classification viewpoints. Finally, a software library is presented comprising C++ binaries for all the positive definite sparse coding and dictionary learning approaches presented here.

Neuropathic pain: an updated grading system for research and clinical practice.

PubMed

Finnerup, Nanna B; Haroutounian, Simon; Kamerman, Peter; Baron, Ralf; Bennett, David L H; Bouhassira, Didier; Cruccu, Giorgio; Freeman, Roy; Hansson, Per; Nurmikko, Turo; Raja, Srinivasa N; Rice, Andrew S C; Serra, Jordi; Smith, Blair H; Treede, Rolf-Detlef; Jensen, Troels S

2016-08-01

The redefinition of neuropathic pain as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system," which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast, the proposed grading system of possible, probable, and definite neuropathic pain from 2008 has been used to a lesser extent. Here, we report a citation analysis of the original NeuPSIG grading paper of 2008, followed by an analysis of its use by an expert panel and recommendations for an improved grading system. As of February, 2015, 608 eligible articles in Scopus cited the paper, 414 of which cited the neuropathic pain definition. Of 220 clinical studies citing the paper, 56 had used the grading system. The percentage using the grading system increased from 5% in 2009 to 30% in 2014. Obstacles to a wider use of the grading system were identified, including (1) questions about the relative significance of confirmatory tests, (2) the role of screening tools, and (3) uncertainties about what is considered a neuroanatomically plausible pain distribution. Here, we present a revised grading system with an adjusted order, better reflecting clinical practice, improvements in the specifications, and a word of caution that even the "definite" level of neuropathic pain does not always indicate causality. In addition, we add a table illustrating the area of pain and sensory abnormalities in common neuropathic pain conditions and propose areas for further research.

Systemic autoimmune rheumatic disease prevalence in Canada: updated analyses across 7 provinces.

PubMed

Broten, Laurel; Aviña-Zubieta, J Antonio; Lacaille, Diane; Joseph, Lawrence; Hanly, John G; Lix, Lisa; O'Donnell, Siobhan; Barnabe, Cheryl; Fortin, Paul R; Hudson, Marie; Jean, Sonia; Peschken, Christine; Edworthy, Steven M; Svenson, Larry; Pineau, Christian A; Clarke, Ann E; Smith, Mark; Bélisle, Patrick; Badley, Elizabeth M; Bergeron, Louise; Bernatsky, Sasha

2014-04-01

To estimate systemic autoimmune rheumatic disease (SARD) prevalence across 7 Canadian provinces using population-based administrative data evaluating both regional variations and the effects of age and sex. Using provincial physician billing and hospitalization data, cases of SARD (systemic lupus erythematosus, scleroderma, primary Sjögren syndrome, polymyositis/dermatomyositis) were ascertained. Three case definitions (rheumatology billing, 2-code physician billing, and hospital diagnosis) were combined to derive a SARD prevalence estimate for each province, categorized by age, sex, and rural/urban status. A hierarchical Bayesian latent class regression model was fit to account for the imperfect sensitivity and specificity of each case definition. The model also provided sensitivity estimates of different case definition approaches. Prevalence estimates for overall SARD ranged between 2 and 5 cases per 1000 residents across provinces. Similar demographic trends were evident across provinces, with greater prevalence in women and in persons over 45 years old. SARD prevalence in women over 45 was close to 1%. Overall sensitivity was poor, but estimates for each of the 3 case definitions improved within older populations and were slightly higher for men compared to women. Our results are consistent with previous estimates and other North American findings, and provide results from coast to coast, as well as useful information about the degree of regional and demographic variations that can be seen within a single country. Our work demonstrates the usefulness of using multiple data sources, adjusting for the error in each, and providing estimates of the sensitivity of different case definition approaches.

Evaluation of Online Information Sources on Alien Species in Europe: The Need of Harmonization and Integration

NASA Astrophysics Data System (ADS)

Gatto, Francesca; Katsanevakis, Stelios; Vandekerkhove, Jochen; Zenetos, Argyro; Cardoso, Ana Cristina

2013-06-01

Europe is severely affected by alien invasions, which impact biodiversity, ecosystem services, economy, and human health. A large number of national, regional, and global online databases provide information on the distribution, pathways of introduction, and impacts of alien species. The sufficiency and efficiency of the current online information systems to assist the European policy on alien species was investigated by a comparative analysis of occurrence data across 43 online databases. Large differences among databases were found which are partially explained by variations in their taxonomical, environmental, and geographical scopes but also by the variable efforts for continuous updates and by inconsistencies on the definition of "alien" or "invasive" species. No single database covered all European environments, countries, and taxonomic groups. In many European countries national databases do not exist, which greatly affects the quality of reported information. To be operational and useful to scientists, managers, and policy makers, online information systems need to be regularly updated through continuous monitoring on a country or regional level. We propose the creation of a network of online interoperable web services through which information in distributed resources can be accessed, aggregated and then used for reporting and further analysis at different geographical and political scales, as an efficient approach to increase the accessibility of information. Harmonization, standardization, conformity on international standards for nomenclature, and agreement on common definitions of alien and invasive species are among the necessary prerequisites.

Let’s Get Counterinsurgency Right: Collective Action Theory in Joint Publication 3-24

DTIC Science & Technology

2015-04-01

Defense (DOD) revised its Joint Publication 3- 24: Counterinsurgency to refine its definition of counterinsurgency, introduce “tenets and precepts of...updates.21 JP 3-24’s refined definitions make two opposing cases for the role of the population. On one hand, “[Counterinsurgency] COIN is a[n]…effort...new definitions of counterinsurgency seem contradictory, its introduction of “tenets and precepts” further complicates the doctrine’s usefulness

77 FR 53830 - Rules of Practice in Proceedings Relative to Administrative Offsets Initiated Against Former...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

... follows: Sec. 966.3 Definitions. (a) Accounting Service Center refers to the United States Postal Service... 31 CFR parts 900-904. Changes to Sec. 966.3 update the definitions of part 966 to refer to the Postal Service Accounting Service Center (ASC) or successor installation instead of the area Postmaster...

76 FR 54969 - Rate Increase Disclosure and Review: Definitions of “Individual Market” and “Small Group Market”

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... definitions of individual and small group market. This final rule also updates standards for health insurance... Health Service Act (PHS Act) relating to group health plans and health insurance issuers in the group and... health insurance coverage.'' The statute provides that health insurance issuers must submit to the...

Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines

PubMed Central

Phipps, Elizabeth; Prasanna, Devika; Brima, Wunnie

2016-01-01

Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia. Upstream triggers of the well described angiogenic pathways, such as the heme oxygenase and hydrogen sulfide pathways, as well as the roles of autoantibodies, misfolded proteins, nitric oxide, and oxidative stress will be described. We also detail updated definitions, classification schema, and treatment targets of hypertensive disorders of pregnancy put forth by obstetric and hypertensive societies throughout the world. The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a self-limited occurrence. At the very least, we now know that preeclampsia does not end with delivery of the placenta. We conclude by summarizing the latest strategies for prevention and treatment of preeclampsia. A better understanding of this entity will help in the care of at-risk women before delivery and for decades after. PMID:27094609

Coding update of the SMFM definition of low risk for cesarean delivery from ICD-9-CM to ICD-10-CM.

PubMed

Armstrong, Joanne; McDermott, Patricia; Saade, George R; Srinivas, Sindhu K

2017-07-01

In 2015, the Society for Maternal-Fetal Medicine developed a low risk for cesarean delivery definition based on administrative claims-based diagnosis codes described by the International Classification of Diseases, Ninth Revision, Clinical Modification. The Society for Maternal-Fetal Medicine definition is a clinical enrichment of 2 available measures from the Joint Commission and the Agency for Healthcare Research and Quality measures. The Society for Maternal-Fetal Medicine measure excludes diagnosis codes that represent clinically relevant risk factors that are absolute or relative contraindications to vaginal birth while retaining diagnosis codes such as labor disorders that are discretionary risk factors for cesarean delivery. The introduction of the International Statistical Classification of Diseases, 10th Revision, Clinical Modification in October 2015 expanded the number of available diagnosis codes and enabled a greater depth and breadth of clinical description. These coding improvements further enhance the clinical validity of the Society for Maternal-Fetal Medicine definition and its potential utility in tracking progress toward the goal of safely lowering the US cesarean delivery rate. This report updates the Society for Maternal-Fetal Medicine definition of low risk for cesarean delivery using International Statistical Classification of Diseases, 10th Revision, Clinical Modification coding. Copyright © 2017. Published by Elsevier Inc.

LSD (Landing System Development) Impact Simulation

NASA Astrophysics Data System (ADS)

Ullio, R.; Riva, N.; Pellegrino, P.; Deloo, P.

2012-07-01

In the frame of the Exploration Programs, a soft landing on the planet surface is foreseen. To ensure a successful final landing phase, a landing system by using leg tripod design landing legs with adequate crushable damping system was selected, capable of absorbing the residual velocities (vertical, horizontal and angular) at touch- down, insuring stability. TAS-I developed a numerical non linear dynamic methodology for the landing impact simulation of the Lander system by using a commercial explicit finite element analysis code (i.e. Altair RADIOSS). In this paper the most significant FE modeling approaches and results of the analytical simulation of landing impact are reported, especially with respect to the definition of leg dimensioning loads and the design update of selected parts (if necessary).

Primate immunodeficiency virus classification and nomenclature: Review

DOE PAGES

Foley, Brian T.; Leitner, Thomas; Paraskevis, Dimitrios; ...

2016-10-24

The International Committee for the Taxonomy and Nomenclature of Viruses does not rule on virus classifications below the species level. The definition of species for viruses cannot be clearly defined for all types of viruses. The complex and interesting epidemiology of Human Immunodeficiency Viruses demands a detailed and informative nomenclature system, while at the same time it presents challenges such that many of the rules need to be flexibly applied or modified over time. As a result, this review outlines the nomenclature system for primate lentiviruses and provides an update on new findings since the last review was written inmore » 2000.« less

SSME/side loads analysis for flight configuration, revision A. [structural analysis of space shuttle main engine under side load excitation

NASA Technical Reports Server (NTRS)

Holland, W.

1974-01-01

This document describes the dynamic loads analysis accomplished for the Space Shuttle Main Engine (SSME) considering the side load excitation associated with transient flow separation on the engine bell during ground ignition. The results contained herein pertain only to the flight configuration. A Monte Carlo procedure was employed to select the input variables describing the side load excitation and the loads were statistically combined. This revision includes an active thrust vector control system representation and updated orbiter thrust structure stiffness characteristics. No future revisions are planned but may be necessary as system definition and input parameters change.

Defining active sacroiliitis on MRI for classification of axial spondyloarthritis: update by the ASAS MRI working group.

PubMed

Lambert, Robert G W; Bakker, Pauline A C; van der Heijde, Désirée; Weber, Ulrich; Rudwaleit, Martin; Hermann, K G; Sieper, Joachim; Baraliakos, Xenofon; Bennett, Alex; Braun, Jürgen; Burgos-Vargas, Rubén; Dougados, Maxime; Pedersen, Susanne Juhl; Jurik, Anne Grethe; Maksymowych, Walter P; Marzo-Ortega, Helena; Østergaard, Mikkel; Poddubnyy, Denis; Reijnierse, Monique; van den Bosch, Filip; van der Horst-Bruinsma, Irene; Landewé, Robert

2016-11-01

To review and update the existing definition of a positive MRI for classification of axial spondyloarthritis (SpA). The Assessment in SpondyloArthritis International Society (ASAS) MRI working group conducted a consensus exercise to review the definition of a positive MRI for inclusion in the ASAS classification criteria of axial SpA. Existing definitions and new data relevant to the MRI diagnosis and classification of sacroiliitis and spondylitis in axial SpA, published since the ASAS definition first appeared in print in 2009, were reviewed and discussed. The precise wording of the existing definition was examined in detail and the data and a draft proposal were presented to and voted on by the ASAS membership. The clear presence of bone marrow oedema on MRI in subchondral bone is still considered to be the defining observation that determines the presence of active sacroiliitis. Structural damage lesions seen on MRI may contribute to a decision by the observer that inflammatory lesions are genuinely due to SpA but are not required to meet the definition. The existing definition was clarified adding guidelines and images to assist in the application of the definition. The definition of a positive MRI for classification of axial SpA should continue to primarily depend on the imaging features of 'active sacroiliitis' until more data are available regarding MRI features of structural damage in the sacroiliac joint and MRI features in the spine and their utility when used for classification purposes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

THE DEFINITION AND INTERPRETATION OF TERRESTRIAL ENVIRONMENT DESIGN INPUTS FOR VEHICLE DESIGN CONSIDERATIONS

NASA Technical Reports Server (NTRS)

Johnson, Dale L.; Keller, Vernon W.; Vaughan, William W.

2005-01-01

The description and interpretation of the terrestrial environment (0-90 km altitude) is an important driver of aerospace vehicle structural, control, and thermal system design. NASA is currently in the process of reviewing the meteorological information acquired over the past decade and producing an update to the 1993 Terrestrial Environment Guidelines for Aerospace Vehicle Design and Development handbook. This paper addresses the contents of this updated handbook, with special emphasis on new material being included in the areas of atmospheric thermodynamic models, wind dynamics, atmospheric composition, atmospheric electricity, cloud phenomena, atmospheric extremes, sea state, etc. In addition, the respective engineering design elements will be discussed relative to the importance and influence of terrestrial environment inputs that require consideration and interpretation for design applications. Specific lessons learned that have contributed to the advancements made in the acquisition, interpretation, application and awareness of terrestrial environment inputs for aerospace engineering applications are discussed.

National Wetland Plant List Indicator Rating Definitions

DTIC Science & Technology

2012-07-01

ER D C/ CR RE L TN -1 2- 1 National Wetland Plant List Indicator Rating Definitions Co ld R eg io ns R es ea rc h an d En gi ne er in... Rating Definitions Robert W. Lichvar Cold Regions Research and Engineering Laboratory U.S. Army Engineer Research and Development Center 72 Lyme...status ratings in the United States. In 2012 the list, now called the National Wetland Plant List, was updated and approved for use for various

77 FR 65103 - Rules of Practice in Proceedings Relative to Administrative Offsets Initiated Against Former...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-25

.... 0 3. Section 966.3 is revised to read as follows: Sec. 966.3 Definitions. (a) Accounting Service... the Treasury, found at 31 CFR parts 900-904. Changes to Sec. 966.3 update the definitions of part 966 to refer to the Postal Service Accounting Service Center (ASC) or successor installation instead of...

About various definitions of life.

PubMed

Luisi, P L

1998-10-01

The old question of a definition of minimal life is taken up again at the aim of providing a forum for an updated discussion. Briefly discussed are the reasons why such an attempt has previously encountered scepticism, and why such an attempt should be renewed at this stage of the inquiry on the origin of life. Then some of the definitions of life presently used are cited and briefly discussed, starting with the definition adopted by NASA as a general working definition. It is shown that this is too limited if one wishes to provide a broad encompassing definition, and some extensions of it are presented and discussed. Finally it is shown how the different definitions of life reflect the main schools of thought that presently dominate the field on the origin of life.

Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines.

PubMed

Stacul, Fulvio; van der Molen, Aart J; Reimer, Peter; Webb, Judith A W; Thomsen, Henrik S; Morcos, Sameh K; Almén, Torsten; Aspelin, Peter; Bellin, Marie-France; Clement, Olivier; Heinz-Peer, Gertraud

2011-12-01

The Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) has updated its 1999 guidelines on contrast medium-induced nephropathy (CIN). Topics reviewed include the definition of CIN, the choice of contrast medium, the prophylactic measures used to reduce the incidence of CIN, and the management of patients receiving metformin. Key Points • Definition, risk factors and prevention of contrast medium induced nephropathy are reviewed. • CIN risk is lower with intravenous than intra-arterial iodinated contrast medium. • eGFR of 45 ml/min/1.73 m (2) is CIN risk threshold for intravenous contrast medium. • Hydration with either saline or sodium bicarbonate reduces CIN incidence. • Patients with eGFR ≥ 60 ml/min/1.73 m (2) receiving contrast medium can continue metformin normally.

DORIS Starec ground antenna characterization and impact on positioning

NASA Astrophysics Data System (ADS)

Tourain, C.; Moreaux, G.; Auriol, A.; Saunier, J.

2016-12-01

In a geodetic radio frequency observing system the phase center offsets and phase center variations of ground antennae are a fundamental component of mathematical models of the system observables. In this paper we describe work aimed at improving the DORIS Starec ground antenna phase center definition model. Seven antennas were analyzed in the Compact Antenna Test Range (CATR), a dedicated CNES facility. With respect to the manufacturer specified phase center offset, the measured antennae varied between -6 mm and +4 mm due to manufacturing variations. To solve this problem, discussions were held with the manufacturer, leading to an improvement of the manufacturing process. This work results in a reduction in the scatter to ±1 mm. The phase center position has been kept unchanged and associated phase law has been updated and provided to users of the International DORIS Service (IDS). This phase law is applicable to all Starec antennas (before and after manufacturing process consolidation) and is azimuth independent. An error budget taking into account these updated characteristics has been established for the antenna alone: ±2 mm on the horizontal plane and ±3 mm on the up component, maximum error values for antennas named type C (Saunier et al., 2016) produced with consolidated manufacturing process. Finally the impact of this updated characterization on positioning results has been analyzed and shows a scale offset only of the order of +12 mm for the Terrestrial Reference Frame.

Changing Definitions of Sepsis

PubMed Central

Gül, Fethi; Arslantaş, Mustafa Kemal; Cinel, İsmail; Kumar, Anand

2017-01-01

Sepsis is one of the main causes of morbidity and mortality in critically ill patients despite the use of modern antibiotics and resuscitation therapies. Outcomes in sepsis have improved overall, probably because of an enhanced focus on early diagnosis and other improvements in supportive care, but mortality rates still remain unacceptably high. The diagnosis and definition of sepsis is a critical problem due to the heterogeneity of this disease process. Although it is apparent that much more needs to be done to advance our understanding, sepsis and related terms remain difficult to define. A 1991 consensus conference developed initial definitions that systemic inflammatory response syndrome (SIRS) to infection would be called sepsis. Definitions of sepsis and septic shock were revised in 2001 to incorporate the threshold values for organ damage. In early 2016, the new definitions of sepsis and septic shock have changed dramatically. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The consensus document describes organ dysfunction as an acute increase in total Sequential Organ Failure Assessment (SOFA) score two points consequently to the infection. A significant change in the new definitions is the elimination of any mention of SIRS. The Sepsis-3 Task Force also introduced a new bedside index, called the qSOFA, to identify outside of critical care units patients with suspected infection who are likely to develop sepsis. Recently updated the consensus definitions improved specificity compared with the previous descriptions. PMID:28752002

Reexamining organizational configurations: an update, validation, and expansion of the taxonomy of health networks and systems.

PubMed

Dubbs, Nicole L; Bazzoli, Gloria J; Shortell, Stephen M; Kralovec, Peter D

2004-02-01

To (a) assess how the original cluster categories of hospital-led health networks and systems have changed over time; (b) identify any new patterns of cluster configurations; and (c) demonstrate how additional data can be used to refine and enhance the taxonomy measures. DATA SOURCES; 1994 and 1998 American Hospital Association (AHA) Annual Survey of Hospitals. As in the original taxonomy, separate cluster solutions are identified for health networks and health systems by applying three strategic/structural dimensions (differentiation, integration, and centralization) to three components of the health service/product continuum (hospital services, physician arrangements, and provider-based insurance activities). Factor, cluster, and discriminant analyses are used to analyze the 1998 data. Descriptive and comparative methods are used to analyze the updated 1998 taxonomy relative to the original 1994 version. The 1998 cluster categories are similar to the original taxonomy, however, they reveal some new organizational configurations. For the health networks, centralization of product/service lines is occurring more selectively than in the past. For the health systems, participation has grown in and dispersed across a more diverse set of decentralized organizational forms. For both networks and systems, the definition of centralization has changed over time. In its updated form, the taxonomy continues to provide policymakers and practitioners with a descriptive and contextual framework against which to assess organizational programs and policies. There is a need to continue to revisit the taxonomy from time to time because of the persistent evolution of the U.S. health care industry and the consequent shifting of organizational configurations in this arena. There is also value in continuing to move the taxonomy in the direction of refinement/expansion as new opportunities become available.

Emergency department operations dictionary: results of the second performance measures and benchmarking summit.

PubMed

Welch, Shari J; Stone-Griffith, Suzanne; Asplin, Brent; Davidson, Steven J; Augustine, James; Schuur, Jeremiah D

2011-05-01

The public, payers, hospitals, and Centers for Medicare and Medicaid Services (CMS) are demanding that emergency departments (EDs) measure and improve performance, but this cannot be done unless we define the terms used in ED operations. On February 24, 2010, 32 stakeholders from 13 professional organizations met in Salt Lake City, Utah, to standardize ED operations metrics and definitions, which are presented in this consensus paper. Emergency medicine (EM) experts attending the Second Performance Measures and Benchmarking Summit reviewed, expanded, and updated key definitions for ED operations. Prior to the meeting, participants were provided with the definitions created at the first summit in 2006 and relevant documents from other organizations and asked to identify gaps and limitations in the original work. Those responses were used to devise a plan to revise and update the definitions. At the summit, attendees discussed and debated key terminology, and workgroups were created to draft a more comprehensive document. These results have been crafted into two reference documents, one for metrics and the operations dictionary presented here. The ED Operations Dictionary defines ED spaces, processes, patient populations, and new ED roles. Common definitions of key terms will improve the ability to compare ED operations research and practice and provide a common language for frontline practitioners, managers, and researchers. © 2011 by the Society for Academic Emergency Medicine.

Reliable B Cell Epitope Predictions: Impacts of Method Development and Improved Benchmarking

PubMed Central

Kringelum, Jens Vindahl; Lundegaard, Claus; Lund, Ole; Nielsen, Morten

2012-01-01

The interaction between antibodies and antigens is one of the most important immune system mechanisms for clearing infectious organisms from the host. Antibodies bind to antigens at sites referred to as B-cell epitopes. Identification of the exact location of B-cell epitopes is essential in several biomedical applications such as; rational vaccine design, development of disease diagnostics and immunotherapeutics. However, experimental mapping of epitopes is resource intensive making in silico methods an appealing complementary approach. To date, the reported performance of methods for in silico mapping of B-cell epitopes has been moderate. Several issues regarding the evaluation data sets may however have led to the performance values being underestimated: Rarely, all potential epitopes have been mapped on an antigen, and antibodies are generally raised against the antigen in a given biological context not against the antigen monomer. Improper dealing with these aspects leads to many artificial false positive predictions and hence to incorrect low performance values. To demonstrate the impact of proper benchmark definitions, we here present an updated version of the DiscoTope method incorporating a novel spatial neighborhood definition and half-sphere exposure as surface measure. Compared to other state-of-the-art prediction methods, Discotope-2.0 displayed improved performance both in cross-validation and in independent evaluations. Using DiscoTope-2.0, we assessed the impact on performance when using proper benchmark definitions. For 13 proteins in the training data set where sufficient biological information was available to make a proper benchmark redefinition, the average AUC performance was improved from 0.791 to 0.824. Similarly, the average AUC performance on an independent evaluation data set improved from 0.712 to 0.727. Our results thus demonstrate that given proper benchmark definitions, B-cell epitope prediction methods achieve highly significant predictive performances suggesting these tools to be a powerful asset in rational epitope discovery. The updated version of DiscoTope is available at www.cbs.dtu.dk/services/DiscoTope-2.0. PMID:23300419

Updates to building-code maps for the 2015 NEHRP recommended seismic provisions

USGS Publications Warehouse

Luco, Nicolas; Bachman, Robert; Crouse, C.B; Harris, James R.; Hooper, John D.; Kircher, Charles A.; Caldwell, Phillp; Rukstales, Kenneth S.

2015-01-01

With the 2014 update of the U.S. Geological Survey (USGS) National Seismic Hazard Model (NSHM) as a basis, the Building Seismic Safety Council (BSSC) has updated the earthquake ground motion maps in the National Earthquake Hazards Reduction Program (NEHRP) Recommended Seismic Provisions for New Buildings and Other Structures, with partial funding from the Federal Emergency Management Agency. Anticipated adoption of the updated maps into the American Society of Civil Engineers Minimum Design Loads for Building and Other Structures and the International Building and Residential Codes is underway. Relative to the ground motions in the prior edition of each of these documents, most of the updated values are within a ±20% change. The larger changes are, in most cases, due to the USGS NSHM updates, reasons for which are given in companion publications. In some cases, the larger changes are partly due to a BSSC update of the slope of the fragility curve that is used to calculate the risk-targeted ground motions, and/or the introduction by BSSC of a quantitative definition of “active faults” used to calculate deterministic ground motions.

Federal employees health benefits acquisition regulation: large provider agreements, subcontracts, and miscellaneous changes. Final rule.

PubMed

2005-06-01

The Office of Personnel Management (OPM) is issuing this final regulation to amend the Federal Employees Health Benefits Acquisition Regulation (FEHBAR). It establishes requirements, including audit, for Federal Employees Health Benefits Program (FEHB) experience-rated carriers' Large Provider Agreements. It also modifies the dollar threshold for review of carriers' subcontract agreements; revises the definitions of Cost or Pricing Data and Experience-rate to reflect mental health parity requirements; updates the contract records retention requirement; updates the FEHB Clause Matrix; and conforms subpart and paragraph references to Federal Acquisition Regulation (FAR) revisions made since we last updated the FEHBAR.

Statistics: Number of Cancer Survivors

MedlinePlus

... Current Survivorship Funding Opportunities at NCI Active Grant Portfolio Funding History and Trends Definitions Statistics Graphs Home ... Current Survivorship Funding Opportunities at NCI Active Grant Portfolio Funding History and Trends Last Updated: October 17, ...

Updates of pathologic myopia.

PubMed

Ohno-Matsui, Kyoko; Lai, Timothy Y Y; Lai, Chi-Chun; Cheung, Chiu Ming Gemmy

2016-05-01

Complications from pathologic myopia are a major cause of visual impairment and blindness, especially in east Asia. The eyes with pathologic myopia may develop loss of the best-corrected vision due to various pathologies in the macula, peripheral retina and the optic nerve. Despite its importance, the definition of pathologic myopia has been inconsistent. The refractive error or axial length alone often does not adequately reflect the 'pathologic myopia'. Posterior staphyloma, which is a hallmark lesion of pathologic myopia, can occur also in non-highly myopic eyes. Recently a revised classification system for myopic maculopathy has been proposed to standardize the definition among epidemiological studies. In this META-PM (meta analyses of pathologic myopia) study classification, pathologic myopia was defined as the eyes having chorioretinal atrophy equal to or more severe than diffuse atrophy. In addition, the advent of new imaging technologies such as optical coherence tomography (OCT) and three dimensional magnetic resonance imaging (3D MRI) has enabled the detailed observation of various pathologies specific to pathologic myopia. New therapeutic approaches including intravitreal injections of anti-vascular endothelial growth factor agents and the advance of vitreoretinal surgeries have greatly improved the prognosis of patients with pathologic myopia. The purpose of this review article is to provide an update on topics related to the field of pathologic myopia, and to outline the remaining issues which need to be solved in the future. Copyright © 2016 Elsevier Ltd. All rights reserved.

Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines.

PubMed

Phipps, Elizabeth; Prasanna, Devika; Brima, Wunnie; Jim, Belinda

2016-06-06

Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia. Upstream triggers of the well described angiogenic pathways, such as the heme oxygenase and hydrogen sulfide pathways, as well as the roles of autoantibodies, misfolded proteins, nitric oxide, and oxidative stress will be described. We also detail updated definitions, classification schema, and treatment targets of hypertensive disorders of pregnancy put forth by obstetric and hypertensive societies throughout the world. The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a self-limited occurrence. At the very least, we now know that preeclampsia does not end with delivery of the placenta. We conclude by summarizing the latest strategies for prevention and treatment of preeclampsia. A better understanding of this entity will help in the care of at-risk women before delivery and for decades after. Copyright © 2016 by the American Society of Nephrology.

Training Manual for Elements of Interface Definition and Control

NASA Technical Reports Server (NTRS)

Lalli, Vincent R. (Editor); Kastner, Robert E. (Editor); Hartt, Henry N. (Editor)

1997-01-01

The primary thrust of this manual is to ensure that the format and information needed to control interfaces between equipment are clear and understandable. The emphasis is on controlling the engineering design of the interface and not on the functional performance requirements of the system or the internal workings of the interfacing equipment. Interface control should take place, with rare exception, at the interfacing elements and no further. There are two essential sections of the manual. Chapter 2, Principles of Interface Control, discusses how interfaces are defined. It describes different types of interfaces to be considered and recommends a format for the documentation necessary for adequate interface control. Chapter 3, The Process: Through the Design Phases, provides tailored guidance for interface definition and control. This manual can be used to improve planned or existing interface control processes during system design and development. It can also be used to refresh and update the corporate knowledge base. The information presented herein will reduce the amount of paper and data required in interface definition and control processes by as much as 50 percent and will shorten the time required to prepare an interface control document. It also highlights the essential technical parameters that ensure that flight subsystems will indeed fit together and function as intended after assembly and checkout.

Phenomenology and classification of dystonia: a consensus update

PubMed Central

Albanese, Alberto; Bhatia, Kailash; Bressman, Susan B.; DeLong, Mahlon R.; Fahn, Stanley; Fung, Victor S.C.; Hallett, Mark; Jankovic, Joseph; Jinnah, H.A.; Klein, Christine; Lang, Anthony E.; Mink, Jonathan W.; Teller, Jan K.

2013-01-01

This report describes the consensus outcome of an international panel consisting of investigators with years of experience in this field that reviewed the definition and classification of dystonia. Agreement was obtained based on a consensus development methodology during three in-person meetings and manuscript review by mail. Dystonia is defined as a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. Dystonic movements are typically patterned and twisting, and may be tremulous. Dystonia is often initiated or worsened by voluntary action and associated with overflow muscle activation. Dystonia is classified along two axes: clinical characteristics, including age at onset, body distribution, temporal pattern and associated features (additional movement disorders or neurological features), and etiology, which includes nervous system pathology and inheritance. The clinical characteristics fall into several specific dystonia syndromes that help to guide diagnosis and treatment. We provide here a new general definition of dystonia and propose a new classification. We encourage clinicians and researchers to use these innovative definition and classification and test them in the clinical setting on a variety of patients with dystonia. PMID:23649720

Department of Defense Dictionary of Military and Associated Terms

DTIC Science & Technology

2010-11-08

Terminology. 4. Publication Format This edition of JP 1-02 has been published in two basic parts: a . Terms and definitions. These are...understanding and management of the associated term. 5. JP 1-02 Online Availability and Update Schedule JP 1-02 is accessible online as a searchable...As Amended Through 15 February 2016 ii JP 1-02 address: https://jdeis.js.mil/jdeis/. The contents of JP 1-02 are updated on a monthly basis to

Glossary of transit terminology

DOT National Transportation Integrated Search

1994-07-01

This latest edition of APTA's Glossary of Transit Terminology updates the previous glossary that was produced in 1984, and provides significant cross-references. This edition also gives definitions for more recent transit-related terms like National ...

US science academy expands misconduct definition

NASA Astrophysics Data System (ADS)

Gwynne, Peter

2017-06-01

The US National Academy of Sciences (NAS) has updated its misconduct guidelines, reclassifying the misleading use of statistics, failure to retain data and incorrect authorship of papers as “detrimental” rather than merely “questionable”.

42 CFR 5.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... “non-metropolitan areas.” Poverty level means the povery level as defined by the Bureau of the Census, using the poverty index adopted by a Federal Interagency Committee in 1969, and updated each year to...

42 CFR 5.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... “non-metropolitan areas.” Poverty level means the povery level as defined by the Bureau of the Census, using the poverty index adopted by a Federal Interagency Committee in 1969, and updated each year to...

42 CFR 5.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... “non-metropolitan areas.” Poverty level means the povery level as defined by the Bureau of the Census, using the poverty index adopted by a Federal Interagency Committee in 1969, and updated each year to...

42 CFR 5.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... “non-metropolitan areas.” Poverty level means the povery level as defined by the Bureau of the Census, using the poverty index adopted by a Federal Interagency Committee in 1969, and updated each year to...

Error Quantification and Confidence Assessment of Aerothermal Model Predictions for Hypersonic Aircraft (Preprint)

DTIC Science & Technology

2013-09-01

based confidence metric is used to compare several different model predictions with the experimental data. II. Aerothermal Model Definition and...whereas 5% measurement uncertainty is assumed for aerodynamic pressure and heat flux measurements 4p y and 4Q y . Bayesian updating according... definitive conclusions for these particular aerodynamic models. However, given the confidence associated with the 4 sdp predictions for Run 30 (H/D

A Science of Social Work, and Social Work as an Integrative Scientific Discipline: Have We Gone Too Far, or Not Far Enough?

ERIC Educational Resources Information Center

Brekke, John S.

2014-01-01

There are two purposes to this article. The first is to update the science of social work framework. The second is to use recent discussions on the nature of realist science and on social work science to propose a definition of social work as an integrative scientific discipline that complements its definition as a profession.

Occurrence of carbapenem-resistant Escherichia coli from ...

EPA Pesticide Factsheets

E. coli isolates from primary and secondary effluents collected from seven WWTPs between 2003 and 2004 were recovered and then screened using one of four antibiotics (trimethoprim-sulfamethoxazole, ampicillin, tetracycline, and trimethoprim). We now report on the testing of a subset of these isolates to determine whether they met the Centers for Disease Control and Prevention (CDC) 2012 CRE definition (intermediate or full resistance to one or more carbapenem antibiotics (imipenem) and resistant to at least two extended-spectrum cephalosporins (cefotaxime, ceftazidime)) or the updated CDC 2015 definition (resistant to a carbapenem antibiotic or producing a carbapenemase). Based on minimum inhibitory concentrations (MICs), isolates classified as nonsusceptible to imipenem or resistant to the two cephalosporin antibiotics or resistant to a fluoroquinolone (ciprofloxacin) were used for PCR assays targeting nine carbapenemase and extended-spectrum -lactamase (ESBL) genes. Of the 500 antibiotic-resistant E. coli isolates tested, the most prevalent resistance was to cefotaxime (3.6%), followed by ciprofloxacin (2.6%), ceftazidime (2.2%) and imipenem (1.8%). Six (1.2%) isolates were nonsusceptible to imipenem, and resistant to cefotaxime and ceftazidime, meeting the CDC 2012 CRE definition. According to the CDC’s updated definition, eight (1.6%) isolates were CRE with full resistance to imipenem; only two of these eight isolates were also determined to be CRE acco

Equity in the finance of health care: some further international comparisons.

PubMed

Wagstaff, A; van Doorslaer, E; van der Burg, H; Calonge, S; Christiansen, T; Citoni, G; Gerdtham, U G; Gerfin, M; Gross, L; Häkinnen, U; Johnson, P; John, J; Klavus, J; Lachaud, C; Lauritsen, J; Leu, R; Nolan, B; Perán, E; Pereira, J; Propper, C; Puffer, F; Rochaix, L; Rodríguez, M; Schellhorn, M; Winkelhake, O

1999-06-01

This paper presents further international comparisons of progressivity of health care financing systems. The paper builds on the work of Wagstaff et al. [Wagstaff, A., van Doorslaer E., et al., 1992. Equity in the finance of health care: some international comparisons, Journal of Health Economics 11, pp. 361-387] but extends it in a number of directions: we modify the methodology used there and achieve a higher degree of cross-country comparability in variable definitions; we update and extend the cross-section of countries; and we present evidence on trends in financing mixes and progressivity.

service line analytics in the new era.

PubMed

Spence, Jay; Seargeant, Dan

2015-08-01

To succeed under the value-based business model, hospitals and health systems require effective service line analytics that combine inpatient and outpatient data and that incorporate quality metrics for evaluating clinical operations. When developing a framework for collection, analysis, and dissemination of service line data, healthcare organizations should focus on five key aspects of effective service line analytics: Updated service line definitions. Ability to analyze and trend service line net patient revenues by payment source. Access to accurate service line cost information across multiple dimensions with drill-through capabilities. Ability to redesign key reports based on changing requirements. Clear assignment of accountability.

Epidemiology of systemic lupus erythematosus: an update.

PubMed

Stojan, George; Petri, Michelle

2018-03-01

Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial, and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the disease itself, for understanding the risk among the different affected populations, and for identifying the factors responsible for the damage accrual through the years. More accurate estimates of incidence and prevalence of SLE among different ethnicities and minority groups not only in the USA, but also in Europe, Middle East, and Asia have provided new insights into the disease burden around the world. Despite advances in treatment, mortality among SLE patients remains high with significant ethnic and geographic variations. Sex, race, and ethnicity significantly affect SLE incidence, prevalence, and mortality.

Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update

PubMed Central

Krop, Ian; Ismaila, Nofisat; Andre, Fabrice; Bast, Robert C.; Barlow, William; Collyar, Deborah E.; Hammond, M. Elizabeth; Kuderer, Nicole M.; Liu, Minetta C.; Mennel, Robert G.; Van Poznak, Catherine; Wolff, Antonio C.; Stearns, Vered

2018-01-01

Purpose This focused update addresses the use of MammaPrint (Agendia, Irvine, CA) to guide decisions on the use of adjuvant systemic therapy. Methods ASCO uses a signals approach to facilitate guideline updates. For this focused update, the publication of the phase III randomized MINDACT (Microarray in Node-Negative and 1 to 3 Positive Lymph Node Disease May Avoid Chemotherapy) study to evaluate the MammaPrint assay in 6,693 women with early-stage breast cancer provided a signal. An expert panel reviewed the results of the MINDACT study along with other published literature on the MammaPrint assay to assess for evidence of clinical utility. Recommendations If a patient has hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative, node-negative breast cancer, the MammaPrint assay may be used in those with high clinical risk to inform decisions on withholding adjuvant systemic chemotherapy due to its ability to identify a good-prognosis population with potentially limited chemotherapy benefit. Women in the low clinical risk category did not benefit from chemotherapy regardless of genomic MammaPrint risk group. Therefore, the MammaPrint assay does not have clinical utility in such patients. If a patient has hormone receptor–positive, HER2-negative, node-positive breast cancer, the MammaPrint assay may be used in patients with one to three positive nodes and a high clinical risk to inform decisions on withholding adjuvant systemic chemotherapy. However, such patients should be informed that a benefit from chemotherapy cannot be excluded, particularly in patients with greater than one involved lymph node. The clinician should not use the MammaPrint assay to guide decisions on adjuvant systemic therapy in patients with hormone receptor–positive, HER2-negative, node-positive breast cancer at low clinical risk, nor any patient with HER2-positive or triple-negative breast cancer, because of the lack of definitive data in these populations. Additional information can be found at www.asco.org/breast-cancer-guidelines and www.asco.org/guidelineswiki. PMID:28692382

78 FR 38423 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Approving a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-26

... ``retail communication'' as ``any written (including electronic) communication that is distributed or made... to update the definition of ``correspondence'' to ``any written (including electronic) communication... written [[Page 38424

Stage-discharge relations for Black Warrior River at Warrior Dam near Eutaw, Alabama; updated 1985

USGS Publications Warehouse

Nelson, G.H.; Ming, C.O.

1986-01-01

The construction of Warrior Dam, completed in 1962, has resulted in changes to the stage-discharge relations in the vicinity. The scarcity of current-meter measurements, coupled with backwater conditions, make definition of a single stage-discharge relation impossible without considerable error. However, as a useful alternative, limit curves were developed in 1983 that defined the limits of possible stage-discharge relations at the dam tailwater section. Since the 1983 report, 37 discharge values computed through the dam for the flood of December 1983 were used to verify or update the lower end of the limit curves. Data obtained from a current-meter measurement of the February 1961 flood (furnished by the U.S. Army Corps of Engineers) were used to update the upper end of the curves. This report presents the updated information. (USGS)

Evaluation of Non-convective Wind Forecasting Methods in the 15th Operational Weather Squadron Area of Responsibility

DTIC Science & Technology

2012-03-01

Planetary Boundary Layer POD—Probability of Detection RCA—Rossby Centre Regional Atmospheric Model RMSE—Root Mean Square Error RUC—Rapid Update Cycle SWW...SIGNIFICANCE ....................................1  B.  NON-CONVECTIVE WINDS DEFINITIONS AND THRESHOLDS ......4  C .  METEOROLOGY ASSOCIATED WITH NON-CONVECTIVE...19  B.  RESULTS FROM PREVIOUS STUDIES ON THE WGE METHOD ....21  C .  RAPID UPDATE CYCLE (RUC) EMPIRICAL METHOD .....................25  III.  DATA AND

Belgian guidelines for economic evaluations: second edition.

PubMed

Thiry, Nancy; Neyt, Mattias; Van De Sande, Stefaan; Cleemput, Irina

2014-12-01

The aim of this study was to present the updated methodological guidelines for economic evaluations of healthcare interventions (drugs, medical devices, and other interventions) in Belgium. The update of the guidelines was performed by three Belgian health economists following feedback from users of the former guidelines and personal experience. The updated guidelines were discussed with a multidisciplinary team consisting of other health economists, assessors of reimbursement request files, representatives of Belgian databases and representatives of the drugs and medical devices industry. The final document was validated by three external validators that were not involved in the previous discussions. The guidelines give methodological guidance for the following components of an economic evaluation: literature review, perspective of the evaluation, definition of the target population, choice of the comparator, analytic technique and study design, calculation of costs, valuation of outcomes, definition of the time horizon, modeling, handling uncertainty and discounting. We present a reference case that can be considered as the minimal requirement for Belgian economic evaluations of health interventions. These guidelines will improve the methodological quality, transparency and uniformity of the economic evaluations performed in Belgium. The guidelines will also provide support to the researchers and assessors performing or evaluating economic evaluations.

What Information Does Your EHR Contain? Automatic Generation of a Clinical Metadata Warehouse (CMDW) to Support Identification and Data Access Within Distributed Clinical Research Networks.

PubMed

Bruland, Philipp; Doods, Justin; Storck, Michael; Dugas, Martin

2017-01-01

Data dictionaries provide structural meta-information about data definitions in health information technology (HIT) systems. In this regard, reusing healthcare data for secondary purposes offers several advantages (e.g. reduce documentation times or increased data quality). Prerequisites for data reuse are its quality, availability and identical meaning of data. In diverse projects, research data warehouses serve as core components between heterogeneous clinical databases and various research applications. Given the complexity (high number of data elements) and dynamics (regular updates) of electronic health record (EHR) data structures, we propose a clinical metadata warehouse (CMDW) based on a metadata registry standard. Metadata of two large hospitals were automatically inserted into two CMDWs containing 16,230 forms and 310,519 data elements. Automatic updates of metadata are possible as well as semantic annotations. A CMDW allows metadata discovery, data quality assessment and similarity analyses. Common data models for distributed research networks can be established based on similarity analyses.

Interoperable Open-Source Sensor-Net Frameworks with Sensor-Package Workbench Capabilities: Motivation, Survey of Resources, and Exploratory Results

DTIC Science & Technology

2010-06-01

Military Scenario Definition Language (MSDL) for Nontraditional Warfare Scenarios," Paper 09S- SIW -001, Proceedings of the Spring Simulation...Update to the M&S Community," Paper 09S- SIW -002, Proceedings of the Spring Simulation Interoperability Workshop, Simulation Interoperability...Multiple Simulations: An Application of the Military Scenario Definition Language (MSDL)," Paper 09S- SIW -003, Proc. of the Spring Simulation

Revised species definitions and nomenclature of the rose colored Cithaerias butterflies (Lepidoptera, Nymphalidae, Satyrinae).

PubMed

Penz, Carla M; Alexander, Laura G; Devries, Philip J

2014-10-20

This study provides updated species definitions for five rose-colored Cithaerias butterflies, starting with a historical overview of their taxonomy. Given their mostly transparent wings, genitalia morphology yielded the most reliable characters for species definition and identification. Genitalic divergence is more pronounced when multiple species occur in sympatry than between parapatric taxa. Cithaerias aurorina is granted full species status, C. cliftoni is reinstated as a full species, and one new combination is proposed, i.e. C. aurora tambopata. Two new synonyms are proposed, Callitaera phantoma and Callitaera aura = Cithaerias aurora. 

Radioisotope Power Systems Reference Book for Mission Designers and Planners

NASA Technical Reports Server (NTRS)

Lee, Young; Bairstow, Brian

2015-01-01

The RPS Program's Program Planning and Assessment (PPA) Office commissioned the Mission Analysis team to develop the Radioisotope Power Systems (RPS) Reference Book for Mission Planners and Designers to define a baseline of RPS technology capabilities with specific emphasis on performance parameters and technology readiness. The main objective of this book is to provide RPS technology information that could be utilized by future mission concept studies and concurrent engineering practices. A progress summary from the major branches of RPS technology research provides mission analysis teams with a vital tool for assessing the RPS trade space, and provides concurrent engineering centers with a consistent set of guidelines for RPS performance characteristics. This book will be iterated when substantial new information becomes available to ensure continued relevance, serving as one of the cornerstone products of the RPS PPA Office. This book updates the original 2011 internal document, using data from the relevant publicly released RPS technology references and consultations with RPS technologists. Each performance parameter and RPS product subsection has been reviewed and cleared by at least one subject matter representative. A virtual workshop was held to reach consensus on the scope and contents of the book, and the definitions and assumptions that should be used. The subject matter experts then reviewed and updated the appropriate sections of the book. The RPS Mission Analysis Team then performed further updates and crosschecked the book for consistency. Finally, a second virtual workshop was held to ensure all subject matter experts and stakeholders concurred on the contents.

Update on Leukodystrophies: A Historical Perspective and Adapted Definition.

PubMed

Kevelam, Sietske H; Steenweg, Marjan E; Srivastava, Siddharth; Helman, Guy; Naidu, Sakkubai; Schiffmann, Raphael; Blaser, Susan; Vanderver, Adeline; Wolf, Nicole I; van der Knaap, Marjo S

2016-12-01

Leukodystrophies were defined in the 1980s as progressive genetic disorders primarily affecting myelin of the central nervous system. At that time, a limited number of such disorders and no associated gene defects were known. The majority of the leukodystrophy patients remained without a specific diagnosis. In the following two decades, magnetic resonance imaging pattern recognition revolutionized the field, allowing the definition of numerous novel leukodystrophies. Their genetic defects were usually identified through genetic linkage studies. This process required substantial numbers of cases and many rare disorders remained unclarified. As recently as 2010, 50% of the leukodystrophy patients remained unclassified. Since 2011, whole-exome sequencing has resulted in an exponential increase in numbers of known, distinct, genetically determined, ultrarare leukodystrophies. We performed a retrospective study concerning three historical cohorts of unclassified leukodystrophy patients and found that currently at least 80% of the patients can be molecularly classified. Based on the original definition of the leukodystrophies, numerous defects in proteins important in myelin structure, maintenance, and function were expected. By contrast, a high percentage of the newly identified gene defects affect the housekeeping process of mRNA translation, shedding new light on white matter pathobiology and requiring adaptation of the leukodystrophy definition. Georg Thieme Verlag KG Stuttgart · New York.

Integrated information theory of consciousness: an updated account.

PubMed

Tononi, G

2012-01-01

This article presents an updated account of integrated information theory of consciousness (IIT) and some of its implications. IIT stems from thought experiments that lead to phenomenological axioms and ontological postulates. The information axiom asserts that every experience is one out of many, i.e. specific - it is what it is by differing in its particular way from a large repertoire of alternatives. The integration axiom asserts that each experience is one, i.e. unified - it cannot be reduced to independent components. The exclusion axiom asserts that every experience is definite - it is limited to particular things and not others and flows at a particular speed and resolution. IIT formalizes these intuitions with three postulates. The information postulate states that only "differences that make a difference" from the intrinsic perspective of a system matter: a mechanism generates cause-effect information if its present state has specific past causes and specific future effects within a system. The integration postulate states that only information that is irreducible matters: mechanisms generate integrated information only to the extent that the information they generate cannot be partitioned into that generated within independent components. The exclusion postulate states that only maxima of integrated information matter: a mechanism specifies only one maximally irreducible set of past causes and future effects - a concept. A complex is a set of elements specifying a maximally irreducible constellation of concepts, where the maximum is evaluated at the optimal spatio-temporal scale. Its concepts specify a maximally integrated conceptual information structure or quale, which is identical with an experience. Finally, changes in information integration upon exposure to the environment reflect a system's ability to match the causal structure of the world. After introducing an updated definition of information integration and related quantities, the article presents some theoretical considerations about the relationship between information and causation and about the relational structure of concepts within a quale. It also explores the relationship between the temporal grain size of information integration and the dynamic of metastable states in the corticothalamic complex. Finally, it summarizes how IIT accounts for empirical findings about the neural substrate of consciousness, and how various aspects of phenomenology may in principle be addressed in terms of the geometry of information integration.

Integrated information theory of consciousness: an updated account.

PubMed

Tononi, G

2012-12-01

This article presents an updated account of integrated information theory of consciousness (liT) and some of its implications. /IT stems from thought experiments that lead to phenomenological axioms (existence, compositionality, information, integration, exclusion) and corresponding ontological postulates. The information axiom asserts that every experience is spec~fic - it is what it is by differing in its particular way from a large repertoire of alternatives. The integration axiom asserts that each experience is unified- it cannot be reduced to independent components. The exclusion axiom asserts that every experience is definite - it is limited to particular things and not others and flows at a particular speed and resolution. /IT formalizes these intuitions with postulates. The information postulate states that only "differences that make a difference" from the intrinsic perpective of a system matter: a mechanism generates cause-effect information if its present state has selective past causes and selective future effects within a system. The integration postulate states that only information that is irreducible matters: mechanisms generate integrated information only to the extent that the information they generate cannot be partitioned into that generated within independent components. The exclusion postulate states that only maxima of integrated information matter: a mechanism specifies only one maximally irreducible set of past causes and future effects - a concept. A complex is a set of elements specifying a maximally irreducible constellation of concepts, where the maximum is evaluated over elements and at the optimal spatiatemporal scale. Its concepts specify a maximally integrated conceptual information structure or quale, which is identical with an experience. Finally, changes in information integration upon exposure to the environment reflect a system's ability to match the causal structure of the world. After introducing an updated definition of information integration and related quantities, the article presents some theoretical considerations about the relationship between information and causation and about the relational structure of concepts within a qua/e. It also explores the relationship between the temporal grain size of information integration and the dynamic of metastable states in the corticothalamic complex. Finally, it summarizes how liT accounts for empirical findings about the neural substrate of consciousness, and how various aspects of phenomenology may in principle be addressed in terms of the geometry of information integration.

A model-updating procedure to stimulate piezoelectric transducers accurately.

PubMed

Piranda, B; Ballandras, S; Steichen, W; Hecart, B

2001-09-01

The use of numerical calculations based on finite element methods (FEM) has yielded significant improvements in the simulation and design of piezoelectric transducers piezoelectric transducer utilized in acoustic imaging. However, the ultimate precision of such models is directly controlled by the accuracy of material characterization. The present work is dedicated to the development of a model-updating technique adapted to the problem of piezoelectric transducer. The updating process is applied using the experimental admittance of a given structure for which a finite element analysis is performed. The mathematical developments are reported and then applied to update the entries of a FEM of a two-layer structure (a PbZrTi-PZT-ridge glued on a backing) for which measurements were available. The efficiency of the proposed approach is demonstrated, yielding the definition of a new set of constants well adapted to predict the structure response accurately. Improvement of the proposed approach, consisting of the updating of material coefficients not only on the admittance but also on the impedance data, is finally discussed.

TEQUEL: The query language of SADDLE

NASA Technical Reports Server (NTRS)

Rajan, S. D.

1984-01-01

A relational database management system is presented that is tailored for engineering applications. A wide variety of engineering data types are supported and the data definition language (DDL) and data manipulation language (DML) are extended to handle matrices. The system can be used either in the standalone mode or through a FORTRAN or PASCAL application program. The query language is of the relational calculus type and allows the user to store, retrieve, update and delete tuples from relations. The relational operations including union, intersect and differ facilitate creation of temporary relations that can be used for manipulating information in a powerful manner. Sample applications are shown to illustrate the creation of data through a FORTRAN program and data manipulation using the TEQUEL DML.

17 CFR 270.0-1 - Definition of terms used in this part.

Code of Federal Regulations, 2013 CFR

2013-04-01

... persons, since the beginning of the fund's last two completed fiscal years, is or was sufficiently limited... from such person to provide them with information necessary to make their determination and to update...

75 FR 77745 - Federal Acquisition Regulation; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-13

... purposes of updating. List of Subjects in 48 CFR Parts 3, 5, 7, and 10 Government procurement. Dated... [Amended] 0 2. Amend section 3.104-1 by removing from the definition ``Federal agency procurement,'' in the...

Arctic freshwater synthesis: Introduction

NASA Astrophysics Data System (ADS)

Prowse, T.; Bring, A.; Mârd, J.; Carmack, E.

2015-11-01

In response to a joint request from the World Climate Research Program's Climate and Cryosphere Project, the International Arctic Science Committee, and the Arctic Council's Arctic Monitoring and Assessment Program, an updated scientific assessment has been conducted of the Arctic Freshwater System (AFS), entitled the Arctic Freshwater Synthesis (AFSΣ). The major reason for joint request was an increasing concern that changes to the AFS have produced, and could produce even greater, changes to biogeophysical and socioeconomic systems of special importance to northern residents and also produce extra-Arctic climatic effects that will have global consequences. Hence, the key objective of the AFSΣ was to produce an updated, comprehensive, and integrated review of the structure and function of the entire AFS. The AFSΣ was organized around six key thematic areas: atmosphere, oceans, terrestrial hydrology, terrestrial ecology, resources and modeling, and the review of each coauthored by an international group of scientists and published as separate manuscripts in this special issue of Journal of Geophysical Research-Biogeosciences. This AFSΣ—Introduction reviews the motivations for, and foci of, previous studies of the AFS, discusses criteria used to define the domain of the AFS, and details key characteristics of the definition adopted for the AFSΣ.

Birth, growth and progresses through the last twelve years of a regional scale landslide warning system

NASA Astrophysics Data System (ADS)

Fanti, Riccardo; Segoni, Samuele; Rosi, Ascanio; Lagomarsino, Daniela; Catani, Filippo

2017-04-01

SIGMA is a regional landslide warning system that operates in the Emilia Romagna region (Italy). In this work, we depict its birth and the continuous development process, still ongoing, after over a decade of operational employ. Traditionally, landslide rainfall thresholds are defined by the empirical correspondence between a rainfall database and a landslide database. However, in the early stages of the research, a complete catalogue of dated landslides was not available. Therefore, the prototypal version of SIGMA was based on rainfall thresholds defined by means of a statistical analysis performed over the rainfall time series. SIGMA was purposely designed to take into account both shallow and deep seated landslides and it was based on the hypothesis that anomalous or extreme values of accumulated rainfall are responsible for landslide triggering. The statistical distribution of the rainfall series was analyzed, and multiples of the standard deviation (σ) were used as thresholds to discriminate between ordinary and extraordinary rainfall events. In the warning system, the measured and the forecasted rainfall are compared with these thresholds. Since the response of slope stability to rainfall may be complex, SIGMA is based on a decision algorithm aimed at identifying short but exceptionally intense rainfalls and mild but exceptionally prolonged rains: while the former are commonly associated with shallow landslides, the latter are mainly associated with deep-seated landslides. In the first case, the rainfall threshold is defined by high σ values and short durations (i.e. a few days); in the second case, σ values are lower but the decision algorithm checks long durations (i.e. some months). The exact definition of "high" and "low" σ values and of "short" and "long" duration varied through time according as it was adjusted during the evolution of the model. Indeed, since 2005, a constant work was carried out to gather and organize newly available data (rainfall recordings and landslides occurred) and to use them to define more robust relationships between rainfalls and landslide triggering, with the final aim to increase the forecasting effectiveness of the warning system. The updated rainfall and landslide database were used to periodically perform a quantitative validation and to analyze the errors affecting the system forecasts. The errors characterization was used to implement a continuous process of updating and modification of SIGMA, that included: - Main model upgrades (generalization from a pilot test site to the whole Emilia Romagna region; calibration against well documented landslide events to define specific σ levels for each territorial units; definition of different alert levels according to the number of expected - Ordinary updates (periodically, the new landslide and rainfall data were used to re-calibrate the thresholds, taking into account a more robust sample). - Model tuning (set up of the optimal version of the decisional algorithm, including different definitions of "long" and "short" periods; selection of the optimal reference rain gauge for each Territorial Unit; modification of the boundaries of some territorial - Additional features (definition of a module that takes into account the effect of snow melt and snow accumulation; coupling with a landslide susceptibility model to improve the spatial accuracy of the model). - Various performance tests (including the comparison with alternate versions of SIGMA or with thresholds based on rainfall intensity and duration). This process has led to an evolution of the warning system and to a documented improvement of its forecasting effectiveness. Landslide forecasting at regional scale is a very complex task, but as time passes by and with the systematic gathering of new substantial data and the continuous progresses of research, uncertainties can be progressively reduced and a warning system can be set that increases its performances and reliability with time.

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

PubMed Central

Singer, Mervyn; Deutschman, Clifford S.; Seymour, Christopher Warren; Shankar-Hari, Manu; Annane, Djillali; Bauer, Michael; Bellomo, Rinaldo; Bernard, Gordon R.; Chiche, Jean-Daniel; Coopersmith, Craig M.; Hotchkiss, Richard S.; Levy, Mitchell M.; Marshall, John C.; Martin, Greg S.; Opal, Steven M.; Rubenfeld, Gordon D.; van der Poll, Tom; Vincent, Jean-Louis; Angus, Derek C.

2016-01-01

IMPORTANCE Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. OBJECTIVE To evaluate and, as needed, update definitions for sepsis and septic shock. PROCESS A task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Definitions and clinical criteria were generated through meetings, Delphi processes, analysis of electronic health record databases, and voting, followed by circulation to international professional societies, requesting peer review and endorsement (by 31 societies listed in the Acknowledgment). KEY FINDINGS FROMEVIDENCE SYNTHESIS Limitations of previous definitions included an excessive focus on inflammation, the misleading model that sepsis follows a continuum through severe sepsis to shock, and inadequate specificity and sensitivity of the systemic inflammatory response syndrome (SIRS) criteria. Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to discrepancies in reported incidence and observed mortality. The task force concluded the term severe sepsis was redundant. RECOMMENDATIONS Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. For clinical operationalization, organ dysfunction can be represented by an increase in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. Septic shock should be defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. Patients with septic shock can be clinically identified by a vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia. This combination is associated with hospital mortality rates greater than 40%. In out-of-hospital, emergency department, or general hospital ward settings, adult patients with suspected infection can be rapidly identified as being more likely to have poor outcomes typical of sepsis if they have at least 2 of the following clinical criteria that together constitute a new bedside clinical score termed quickSOFA (qSOFA): respiratory rate of 22/min or greater, altered mentation, or systolic blood pressure of 100 mm Hg or less. CONCLUSIONS AND RELEVANCE These updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsis or at risk of developing sepsis. PMID:26903338

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

PubMed

Singer, Mervyn; Deutschman, Clifford S; Seymour, Christopher Warren; Shankar-Hari, Manu; Annane, Djillali; Bauer, Michael; Bellomo, Rinaldo; Bernard, Gordon R; Chiche, Jean-Daniel; Coopersmith, Craig M; Hotchkiss, Richard S; Levy, Mitchell M; Marshall, John C; Martin, Greg S; Opal, Steven M; Rubenfeld, Gordon D; van der Poll, Tom; Vincent, Jean-Louis; Angus, Derek C

2016-02-23

Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. To evaluate and, as needed, update definitions for sepsis and septic shock. A task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Definitions and clinical criteria were generated through meetings, Delphi processes, analysis of electronic health record databases, and voting, followed by circulation to international professional societies, requesting peer review and endorsement (by 31 societies listed in the Acknowledgment). Limitations of previous definitions included an excessive focus on inflammation, the misleading model that sepsis follows a continuum through severe sepsis to shock, and inadequate specificity and sensitivity of the systemic inflammatory response syndrome (SIRS) criteria. Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to discrepancies in reported incidence and observed mortality. The task force concluded the term severe sepsis was redundant. Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. For clinical operationalization, organ dysfunction can be represented by an increase in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. Septic shock should be defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. Patients with septic shock can be clinically identified by a vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia. This combination is associated with hospital mortality rates greater than 40%. In out-of-hospital, emergency department, or general hospital ward settings, adult patients with suspected infection can be rapidly identified as being more likely to have poor outcomes typical of sepsis if they have at least 2 of the following clinical criteria that together constitute a new bedside clinical score termed quickSOFA (qSOFA): respiratory rate of 22/min or greater, altered mentation, or systolic blood pressure of 100 mm Hg or less. These updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsis or at risk of developing sepsis.

Update of the International Consensus on Palliative Radiotherapy Endpoints for Future Clinical Trials in Bone Metastases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chow, Edward, E-mail: Edward.Chow@sunnybrook.ca; Hoskin, Peter; Mitera, Gunita

2012-04-01

Purpose: To update the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases by surveying international experts regarding previous uncertainties within the 2002 consensus, changes that may be necessary based on practice pattern changes and research findings since that time. Methods and Materials: A two-phase survey was used to determine revisions and new additions to the 2002 consensus. A total of 49 experts from the American Society for Radiation Oncology, the European Society for Therapeutic Radiology and Oncology, the Faculty of Radiation Oncology of the Royal Australian and New Zealand College of Radiologists, and the Canadianmore » Association of Radiation Oncology who are directly involved in the care of patients with bone metastases participated in this survey. Results: Consensus was established in areas involving response definitions, eligibility criteria for future trials, reirradiation, changes in systemic therapy, radiation techniques, parameters at follow-up, and timing of assessments. Conclusion: An outline for trials in bone metastases was updated based on survey and consensus. Investigators leading trials in bone metastases are encouraged to adopt the revised guideline to promote consistent reporting. Areas for future research were identified. It is intended for the consensus to be re-examined in the future on a regular basis.« less

Mental Disorder-The Need for an Accurate Definition.

PubMed

Telles-Correia, Diogo; Saraiva, Sérgio; Gonçalves, Jorge

2018-01-01

There are several reasons why a definition for mental disorder is essential. Among these are not only reasons linked to psychiatry itself as a science (nosology, research) but also to ethical, legal, and financial issues. The first formal definition of mental disorder resulted from a deep conceptual analysis led by Robert Spitzer. It emerged to address several challenges that psychiatry faced at the time, namely to serve as the starting point for an atheoretical and evidence-based classification of mental disorders, to justify the removal of homosexuality from classifications, and to counter the arguments of antipsychiatry. This definition has been updated, with some conceptual changes that make it depart from the main assumptions of Spitzer's original definition. In this article, we intend to review the factors that substantiated the emergence of the first formal definition of mental disorder that based all its later versions.

SmartWay strategic plan : 2007 annual report

DOT National Transportation Integrated Search

2007-12-01

This document presents an update to the ITS Strategic Plan, effective December 2007. The key plan elements are listed below: a definition of ITS, ITS user services relevant to the agency; performance measures to identify roadway segments and corridor...

Designing a User Manual to Support an In-House Database.

ERIC Educational Resources Information Center

Kraft, Melissa A.; Pugh, W. Jean

1988-01-01

Describes the steps involved in designing a user manual for an in-house database. Topics covered include goal definition, target audience identification, production scheduling, design and production choices, testing and review, and updating of the manual. (CLB)

76 FR 26224 - Revisions to the California State Implementation Plan, Northern Sonoma County Air Pollution...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-06

... Significant Deterioration (PSD) permit programs. These proposed revisions update the definitions used in the districts' PSD permit programs. DATES: Any comments on this proposal must arrive by June 6, 2011. ADDRESSES...

76 FR 55842 - Partial Approval and Partial Disapproval of Air Quality Implementation Plans; California; San...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... sometimes approves a rule only as a SIP strengthening action (e.g., to update definitions, add test methods... standards (e.g., materials specifications, test methods, sampling procedures, and business practices) that...

AGU's Updated Scientific Integrity and Professional Ethics Policy

NASA Astrophysics Data System (ADS)

McPhaden, M. J.

2017-12-01

AGU'S mission is to promote discovery in Earth and space science for the benefit of humanity. This mission can only be accomplished if all those engaged in the scientific enterprise uphold the highest standards of scientific integrity and professional ethics. AGU's Scientific Integrity and Professional Ethics Policy provides a set of principles and guidelines for AGU members, staff, volunteers, contractors, and non-members participating in AGU sponsored programs and activities. The policy has recently been updated to include a new code of conduct that broadens the definition of scientific misconduct to include discrimination, harassment, and bullying. This presentation provides the context for what motivated the updated policy, an outline of the policy itself, and a discussion of how it is being communicated and applied.

Sixth Annual Workshop on Meteorological and Environmental Inputs to Aviation Systems, 26-28 October 1982, Tullahoma, Tenn

NASA Technical Reports Server (NTRS)

Camp, D. W.; Frost, W.; Coons, F.; Evanich, P.; Sprinkle, C. H.

1984-01-01

The six workshops whose proceedings are presently reported considered the subject of meteorological and environmental information inputs to aviation, in order to satisfy workshop-sponsoring agencies' requirements for (1) greater knowledge of the interaction of the atmosphere with aircraft and airport operators, (2) a better definition and implementation of meteorological services to operators, and (3) the collection and interpretation of data useful in establishing operational criteria that relate the atmospheric science input to aviation community operations. Workshop topics included equipment and instrumentation, forecasts and information updates, training and simulation facilities, and severe weather, icing and wind shear.

Large Deployable Reflector (LDR) system concept and technology definition study. Analysis of space station requirements for LDR

NASA Astrophysics Data System (ADS)

Agnew, Donald L.; Vinkey, Victor F.; Runge, Fritz C.

1989-04-01

A study was conducted to determine how the Large Deployable Reflector (LDR) might benefit from the use of the space station for assembly, checkout, deployment, servicing, refurbishment, and technology development. Requirements that must be met by the space station to supply benefits for a selected scenario are summarized. Quantitative and qualitative data are supplied. Space station requirements for LDR which may be utilized by other missions are identified. A technology development mission for LDR is outlined and requirements summarized. A preliminary experiment plan is included. Space Station Data Base SAA 0020 and TDM 2411 are updated.

Large Deployable Reflector (LDR) system concept and technology definition study. Analysis of space station requirements for LDR

NASA Technical Reports Server (NTRS)

Agnew, Donald L.; Vinkey, Victor F.; Runge, Fritz C.

1989-01-01

A study was conducted to determine how the Large Deployable Reflector (LDR) might benefit from the use of the space station for assembly, checkout, deployment, servicing, refurbishment, and technology development. Requirements that must be met by the space station to supply benefits for a selected scenario are summarized. Quantitative and qualitative data are supplied. Space station requirements for LDR which may be utilized by other missions are identified. A technology development mission for LDR is outlined and requirements summarized. A preliminary experiment plan is included. Space Station Data Base SAA 0020 and TDM 2411 are updated.

Design of the SGML-based electronic patient record system with the use of object-oriented analysis methods.

PubMed

Kuikka, E; Eerola, A; Porrasmaa, J; Miettinen, A; Komulainen, J

1999-01-01

Since a patient record is typically a document updated by many users, required to be represented in many different layouts, and transferred from place to place, it is a good candidate to be represented structured and coded using the SGML document standard. The use of the SGML requires that the structure of the document is defined in advance by a Document Type Definition (DTD) and the document follows it. This paper represents a method which derives an SGML DTD by starting from the description of the usage of the patient record in medical care and nursing.

An Integrated Approach to Functional Engineering: An Engineering Database for Harness, Avionics and Software

NASA Astrophysics Data System (ADS)

Piras, Annamaria; Malucchi, Giovanni

2012-08-01

In the design and development phase of a new program one of the critical aspects is the integration of all the functional requirements of the system and the control of the overall consistency between the identified needs on one side and the available resources on the other side, especially when both the required needs and available resources are not yet consolidated, but they are evolving as the program maturity increases.The Integrated Engineering Harness Avionics and Software database (IDEHAS) is a tool that has been developed to support this process in the frame of the Avionics and Software disciplines through the different phases of the program. The tool is in fact designed to allow an incremental build up of the avionics and software systems, from the description of the high level architectural data (available in the early stages of the program) to the definition of the pin to pin connectivity information (typically consolidated in the design finalization stages) and finally to the construction and validation of the detailed telemetry parameters and commands to be used in the test phases and in the Mission Control Centre. The key feature of this approach and of the associated tool is that it allows the definition and the maintenance / update of all these data in a single, consistent environment.On one side a system level and concurrent approach requires the feasibility to easily integrate and update the best data available since the early stages of a program in order to improve confidence in the consistency and to control the design information.On the other side, the amount of information of different typologies and the cross-relationships among the data imply highly consolidated structures requiring lot of checks to guarantee the data content consistency with negative effects on simplicity and flexibility and often limiting the attention to special needs and to the interfaces with other disciplines.

Clinical diagnosis and staging of cholangiocarcinoma

PubMed Central

Blechacz, Boris; Komuta, Mina; Roskams, Tania; Gores, Gregory J.

2012-01-01

Cholangiocarcinoma is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria. Currently, cholangiocarcinoma is classified into the following types according to its anatomic location along the biliary tree: intrahepatic, perihilar or distal extrahepatic cholangiocarcinoma. These cholangiocarcinoma types differ in their biological behavior and management. The appropriate stratification of patients with regard to the anatomic location and stage of cholangiocarcinoma is a key determinate in their management. Staging systems can guide this stratification and provide prognostic information. In addition, staging systems are essential in order to compare and contrast the outcomes of different therapeutic approaches. A number of staging systems exist for cholangiocarcinoma—several early ones have been updated, and new ones are being developed. We discuss the emerging diagnostic criteria as well as the different staging systems for cholangiocarcinoma, and provide a critical appraisal regarding these advances in biliary tract malignancies. PMID:21808282

ARCADIA: a system for the integration of angiocardiographic data and images by an object-oriented DBMS.

PubMed

Pinciroli, F; Combi, C; Pozzi, G

1995-02-01

Use of data base techniques to store medical records has been going on for more than 40 years. Some aspects still remain unresolved, e.g., the management of textual data and image data within a single system. Object-orientation techniques applied to a database management system (DBMS) allow the definition of suitable data structures (e.g., to store digital images): some facilities allow the use of predefined structures when defining new ones. Currently available object-oriented DBMS, however, still need improvements both in the schema update and in the query facilities. This paper describes a prototype of a medical record that includes some multimedia features, managing both textual and image data. The prototype here described considers data from the medical records of patients subjected to percutaneous transluminal coronary artery angioplasty. We developed it on a Sun workstation with a Unix operating system and ONTOS as an object-oriented DBMS.

Guidelines for the revision of practice data sets.

PubMed

Culpepper, L

1980-09-01

As residencies and practices mature, a frequent undertaking is the revision of initial data sets and information systems. This report presents an expanded data set which has been developed in the Family Medicine Residency Program at the University of Rochester and suggests guidelines for the selection of data items and revision of existing information systems. In the selection of data items it is important to carefully identify planned use and definition of terms, as well as to carefully consider the complexity of the items and the realistic ability of personnel to maintain and update both individual items and the entire set of data. The implementation of a revised data system requires careful planning and frequent involvement of staff to insure accurate collection of information and proper managment of workload. The implementation phase should not be considered complete until an ongoing system for reviewing and maintaining data is established.

Phenomenology and classification of dystonia: a consensus update.

PubMed

Albanese, Alberto; Bhatia, Kailash; Bressman, Susan B; Delong, Mahlon R; Fahn, Stanley; Fung, Victor S C; Hallett, Mark; Jankovic, Joseph; Jinnah, Hyder A; Klein, Christine; Lang, Anthony E; Mink, Jonathan W; Teller, Jan K

2013-06-15

This report describes the consensus outcome of an international panel consisting of investigators with years of experience in this field that reviewed the definition and classification of dystonia. Agreement was obtained based on a consensus development methodology during 3 in-person meetings and manuscript review by mail. Dystonia is defined as a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. Dystonic movements are typically patterned and twisting, and may be tremulous. Dystonia is often initiated or worsened by voluntary action and associated with overflow muscle activation. Dystonia is classified along 2 axes: clinical characteristics, including age at onset, body distribution, temporal pattern and associated features (additional movement disorders or neurological features); and etiology, which includes nervous system pathology and inheritance. The clinical characteristics fall into several specific dystonia syndromes that help to guide diagnosis and treatment. We provide here a new general definition of dystonia and propose a new classification. We encourage clinicians and researchers to use these innovative definition and classification and test them in the clinical setting on a variety of patients with dystonia. © 2013 Movement Disorder Society. © 2013 Movement Disorder Society.

Updating OSHA standards based on national consensus standards. Direct final rule.

PubMed

2007-12-14

In this direct final rule, the Agency is removing several references to consensus standards that have requirements that duplicate, or are comparable to, other OSHA rules; this action includes correcting a paragraph citation in one of these OSHA rules. The Agency also is removing a reference to American Welding Society standard A3.0-1969 ("Terms and Definitions") in its general-industry welding standards. This rulemaking is a continuation of OSHA's ongoing effort to update references to consensus and industry standards used throughout its rules.

General Education! Not Again?

ERIC Educational Resources Information Center

Marsee, Stuart

After reviewing definitions of general education and statements regarding its importance found in the literature, this paper presents observations to be considered in updating or developing general education programs. It is observed that many disciplines have developed excessive departmentalization; that administrators tend to view general…

Description of Updates for MCCEM Version 1.2 (February 2001)

EPA Pesticide Factsheets

The EPA Office of Pollution Prevention and Toxics, Economics, Exposure, and Technology Division has developed several exposure assessment tools and models. A description of the models and tools and the definition of exposure are given in separate web page

Glossary of bioinformatics terms.

PubMed

2007-06-01

This collection of terms and definitions commonly encountered in the bioinformatics literature will be updated periodically as Current Protocols in Bioinformatics grows. In addition, an extensive glossary of genetic terms can be found on the Web site of the National Human Genome Research Institute (http://www.genome.gov/glossary.cfm). The entries in that online glossary provide a brief written definition of the term; the user can also listen to an informative explanation of the term using RealAudio or the Windows Media Player.

78 FR 72155 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

...This rule updates and makes revisions to the End-Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2014. This rule also sets forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2016 and beyond. In addition, this rule clarifies the grandfathering provision related to the 3-year minimum lifetime requirement (MLR) for Durable Medical Equipment (DME), and provides clarification of the definition of routinely purchased DME. This rule also implements budget-neutral fee schedules for splints and casts, and intraocular lenses (IOLs) inserted in a physician's office. Finally, this rule makes a few technical amendments and corrections to existing regulations related to payment for durable medical equipment, prosthetics, orthotics, and supplies (DMEPOS) items and services.

42 CFR 412.107 - Special treatment: Hospitals that receive an additional update for FYs 1998 and 1999.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the following provisions: (i) The indirect medical education adjustment made under § 412.105. (ii) The... section if it meets all of the following criteria: (1) Definition. The hospital is not a Medicare...

42 CFR 412.107 - Special treatment: Hospitals that receive an additional update for FYs 1998 and 1999.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the following provisions: (i) The indirect medical education adjustment made under § 412.105. (ii) The... section if it meets all of the following criteria: (1) Definition. The hospital is not a Medicare...

76 FR 72996 - Eleventh Meeting: RTCA Special Committee 223 Airport Surface Wireless Communications

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... SESAR P15.2.7 Profiles Definition for AeroMACS Chap 8--Physical Layer--Updates per WiMAX Forum Chap 5... Security Sub-layer--Honeywell Review draft of Environmental (DO-160G)--Rockwell Collins Review draft PICS...

42 CFR 5.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., using the poverty index adopted by a Federal Interagency Committee in 1969, and updated each year to reflect changes in the Consumer Price Index. Secretary means the Secretary of Health and Human Services... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS DESIGNATION OF HEALTH...

Development of the updated system of city underground pipelines based on Visual Studio

NASA Astrophysics Data System (ADS)

Zhang, Jianxiong; Zhu, Yun; Li, Xiangdong

2009-10-01

Our city has owned the integrated pipeline network management system with ArcGIS Engine 9.1 as the bottom development platform and with Oracle9i as basic database for storaging data. In this system, ArcGIS SDE9.1 is applied as the spatial data engine, and the system was a synthetic management software developed with Visual Studio visualization procedures development tools. As the pipeline update function of the system has the phenomenon of slower update and even sometimes the data lost, to ensure the underground pipeline data can real-time be updated conveniently and frequently, and the actuality and integrity of the underground pipeline data, we have increased a new update module in the system developed and researched by ourselves. The module has the powerful data update function, and can realize the function of inputting and outputting and rapid update volume of data. The new developed module adopts Visual Studio visualization procedures development tools, and uses access as the basic database to storage data. We can edit the graphics in AutoCAD software, and realize the database update using link between the graphics and the system. Practice shows that the update module has good compatibility with the original system, reliable and high update efficient of the database.

Sepsis 2018: Definitions and Guideline Changes.

PubMed

Napolitano, Lena M

Sepsis is a global healthcare issue and continues to be the leading cause of death from infection. Early recognition and diagnosis of sepsis is required to prevent the transition into septic shock, which is associated with a mortality rate of 40% or more. New definitions for sepsis and septic shock (Third International Consensus Definitions for Sepsis and Septic Shock [Sepsis-3]) have been developed. A new screening tool for sepsis (quick Sequential Organ Failure Assessment [qSOFA]) has been proposed to predict the likelihood of poor outcome in out-of-intensive care unit (ICU) patients with clinical suspicion of sepsis. The Surviving Sepsis Campaign Guidelines were recently updated and include greater evidence-based recommendations for treatment of sepsis in attempts to reduce sepsis-associated mortality. This review discusses the new Sepsis-3 definitions and guidelines.

Advancing Health Literacy Measurement: A Pathway to Better Health and Health System Performance

PubMed Central

Pleasant, Andrew

2014-01-01

The concept of health literacy initially emerged and continues to gain strength as an approach to improving health status and the performance of health systems. Numerous studies clearly link low levels of education, literacy, and health literacy with poor health, poor health care utilization, increased barriers to care, and early death. However, theoretical understandings and methods of measuring the complex social construct of health literacy have experienced a continual evolution that remains incomplete. As a result, the seemingly most-cited definition of health literacy proposed in the now-decade-old Institute of Medicine report on health literacy is long overdue for updating. Such an effort should engage a broad and diverse set of health literacy researchers, practitioners, and members of the public in creating a definition that can earn broad consensus through validation testing in a rigorous scientific approach. That effort also could produce the basis for a new universally applicable measure of health literacy. Funders, health systems, and policymakers should reconsider their timid approach to health literacy. Although the field and corresponding evidence base are not perfect, health literacy—especially when combined with a focus on prevention and integrative health—is one of the most promising approaches to advancing public health. PMID:25491583

In-service health monitoring of composite structures

NASA Technical Reports Server (NTRS)

Pinto, Gino A.; Ventres, C. S.; Ginty, Carol A.; Chamis, Christos C.

1990-01-01

The aerospace industry is witnessing a vast utilization of composites in critical structural applications and anticipates even more use of them in future aircraft. Therefore, a definite need exists for a composite health monitoring expert system to meet today's current needs and tomorrow's future demands. The primary goal for this conceptual health monitoring system is functional reliably for in-service operation in the environments of various composite structures. The underlying philosophy of this system is to utilize proven vibration techniques to assess the structural integrity of a fibrous composite. Statistical methods are used to determine if the variances in the measured data are acceptable for making a reliable decision on the health status of the composite. The flexible system allows for algorithms describing any composite fatigue or damage behavior characteristic to be provided as an input to the system. Alert thresholds and variances can also be provided as an input to this system and may be updated to allow for future changes/refinements in the composite's structural integrity behavior.

Alternative Fuels Data Center: Status Update: E85 Dispenser System

Science.gov Websites

Alternative Fuels Data Center: Status Update: E85 Dispenser System Certified (June 2010) on Facebook Tweet about Alternative Fuels Data Center: Status Update: E85 Dispenser System Certified (June 2010) on Twitter Bookmark Alternative Fuels Data Center: Status Update: E85 Dispenser System Certified (June 2010

15 CFR 995.4 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... database resulting from the transformation of the ENC by ECDIS for appropriate use, updates to the ENC by... of the 1974 SOLAS Convention. Electronic Navigational Chart (ENC) means a database, standardized as to content, structure, and format, issued for use with ECDIS on the authority of government...

State Requirements for Educational Facilities, 1997.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Office of Educational Facilities.

This document updates Florida's deregulation of construction of educational facilities guidelines, while keeping as the primary focus the safety of the students in pre-K through community college facilities. Organized by the sequence of steps required in the facilities procurement process, it covers general definitions, property…

Crispen's Five Antivirus Rules.

ERIC Educational Resources Information Center

Crispen, Patrick Douglas

2000-01-01

Explains five rules to protect computers from viruses. Highlights include commercial antivirus software programs and the need to upgrade them periodically (every year to 18 months); updating virus definitions at least weekly; scanning attached files from email with antivirus software before opening them; Microsoft Word macro protection; and the…

Life sciences payload definition and integration study, task C and D. Volume 2: Payload definition, integration, and planning studies

NASA Technical Reports Server (NTRS)

1973-01-01

The Life Sciences Payload Definition and Integration Study was composed of four major tasks. Tasks A and B, the laboratory definition phase, were the subject of prior NASA study. The laboratory definition phase included the establishment of research functions, equipment definitions, and conceptual baseline laboratory designs. These baseline laboratories were designated as Maxi-Nom, Mini-30, and Mini-7. The outputs of Tasks A and B were used by the NASA Life Sciences Payload Integration Team to establish guidelines for Tasks C and D, the laboratory integration phase of the study. A brief review of Tasks A and B is presented provide background continuity. The tasks C and D effort is the subject of this report. The Task C effort stressed the integration of the NASA selected laboratory designs with the shuttle sortie module. The Task D effort updated and developed costs that could be used by NASA for preliminary program planning.

Personal computer security: part 1. Firewalls, antivirus software, and Internet security suites.

PubMed

Caruso, Ronald D

2003-01-01

Personal computer (PC) security in the era of the Health Insurance Portability and Accountability Act of 1996 (HIPAA) involves two interrelated elements: safeguarding the basic computer system itself and protecting the information it contains and transmits, including personal files. HIPAA regulations have toughened the requirements for securing patient information, requiring every radiologist with such data to take further precautions. Security starts with physically securing the computer. Account passwords and a password-protected screen saver should also be set up. A modern antivirus program can easily be installed and configured. File scanning and updating of virus definitions are simple processes that can largely be automated and should be performed at least weekly. A software firewall is also essential for protection from outside intrusion, and an inexpensive hardware firewall can provide yet another layer of protection. An Internet security suite yields additional safety. Regular updating of the security features of installed programs is important. Obtaining a moderate degree of PC safety and security is somewhat inconvenient but is necessary and well worth the effort. Copyright RSNA, 2003

RCRA/UST, superfund and EPCRA hotline training module. Introduction to: Definition of solid waste and hazardous waste recycling (40 CFR sections 261.2 and 261.9) updated as of July 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-11-01

The module explains the statutory and regulatory definitions of solid waste, including the standards governing the recycling and management of specific types of wastes. It lists and cites three use/reuse scenarios where the materials are not solid wastes and states the requirements for documentation. It lists examples of sham recycling and describes the conditions under which hazardous waste-derived products may be excluded from regulation. It cites the provisions for precious metal recovery and discusses potential regulatory developments affecting the definition of solid waste and hazardous waste recycling.

San Juan National Forest Land Management Planning Support System (LMPSS) requirements definition

NASA Technical Reports Server (NTRS)

Werth, L. F. (Principal Investigator)

1981-01-01

The role of remote sensing data as it relates to a three-component land management planning system (geographic information, data base management, and planning model) can be understood only when user requirements are known. Personnel at the San Juan National Forest in southwestern Colorado were interviewed to determine data needs for managing and monitoring timber, rangelands, wildlife, fisheries, soils, water, geology and recreation facilities. While all the information required for land management planning cannot be obtained using remote sensing techniques, valuable information can be provided for the geographic information system. A wide range of sensors such as small and large format cameras, synthetic aperture radar, and LANDSAT data should be utilized. Because of the detail and accuracy required, high altitude color infrared photography should serve as the baseline data base and be supplemented and updated with data from the other sensors.

Update of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancer.

PubMed

Al-Mamgani, Abrahim; van Putten, Wim L J; Heemsbergen, Wilma D; van Leenders, Geert J L H; Slot, Annerie; Dielwart, Michel F H; Incrocci, Luca; Lebesque, Joos V

2008-11-15

To update the analysis of the Dutch dose-escalation trial of radiotherapy for prostate cancer. A total of 669 patients with localized prostate cancer were randomly assigned to receive 68 or 78 Gy. The patients were stratified by age, institution, use of neoadjuvant or adjuvant hormonal therapy, and treatment group. The primary endpoint was freedom from failure (FFF), with failure defined as clinical or biochemical failure. Two definitions of biochemical failure were used: the American Society for Therapeutic Radiology and Oncology definition (three consecutive increases in prostate-specific antigen level) and the Phoenix definition (nadir plus 2 microe secondary endpoints were freedom from clinical failure, overall survival, and genitourinary and gastrointestinal toxicity. After a median follow-up of 70 months, the FFF using the American Society for Therapeutic Radiology and Oncology definition was significantly better in the 78-Gy arm than in the 68-Gy arm (7-year FFF rate, 54% vs. 47%, respectively; p = 0.04). The FFF using the Phoenix definition was also significantly better in the 78-Gy arm than in the 68-Gy arm (7-year FFF rate, 56% vs. 45%, respectively; p = 0.03). However, no differences in freedom from clinical failure or overall survival were observed. The incidence of late Grade 2 or greater genitourinary toxicity was similar in both arms (40% and 41% at 7 years; p = 0.6). However, the cumulative incidence of late Grade 2 or greater gastrointestinal toxicity was increased in the 78-Gy arm compared with the 68-Gy arm (35% vs. 25% at 7 years; p = 0.04). The results of our study have shown a statistically significant improvement in FFF in prostate cancer patients treated with 78 Gy but with a greater rate of late gastrointestinal toxicity.

Delivering patient decision aids on the Internet: definitions, theories, current evidence, and emerging research areas

PubMed Central

2013-01-01

Background In 2005, the International Patient Decision Aids Standards Collaboration identified twelve quality dimensions to guide assessment of patient decision aids. One dimension—the delivery of patient decision aids on the Internet—is relevant when the Internet is used to provide some or all components of a patient decision aid. Building on the original background chapter, this paper provides an updated definition for this dimension, outlines a theoretical rationale, describes current evidence, and discusses emerging research areas. Methods An international, multidisciplinary panel of authors examined the relevant theoretical literature and empirical evidence through 2012. Results The updated definition distinguishes Internet-delivery of patient decision aids from online health information and clinical practice guidelines. Theories in cognitive psychology, decision psychology, communication, and education support the value of Internet features for providing interactive information and deliberative support. Dissemination and implementation theories support Internet-delivery for providing the right information (rapidly updated), to the right person (tailored), at the right time (the appropriate point in the decision making process). Additional efforts are needed to integrate the theoretical rationale and empirical evidence from health technology perspectives, such as consumer health informatics, user experience design, and human-computer interaction. Despite Internet usage ranging from 74% to 85% in developed countries and 80% of users searching for health information, it is unknown how many individuals specifically seek patient decision aids on the Internet. Among the 86 randomized controlled trials in the 2011 Cochrane Collaboration’s review of patient decision aids, only four studies focused on Internet-delivery. Given the limited number of published studies, this paper particularly focused on identifying gaps in the empirical evidence base and identifying emerging areas of research. Conclusions As of 2012, the updated theoretical rationale and emerging evidence suggest potential benefits to delivering patient decision aids on the Internet. However, additional research is needed to identify best practices and quality metrics for Internet-based development, evaluation, and dissemination, particularly in the areas of interactivity, multimedia components, socially-generated information, and implementation strategies. PMID:24625064

SDO FlatSat Facility

NASA Technical Reports Server (NTRS)

Amason, David L.

2008-01-01

The goal of the Solar Dynamics Observatory (SDO) is to understand and, ideally, predict the solar variations that influence life and society. It's instruments will measure the properties of the Sun and will take hifh definition images of the Sun every few seconds, all day every day. The FlatSat is a high fidelity electrical and functional representation of the SDO spacecraft bus. It is a high fidelity test bed for Integration & Test (I & T), flight software, and flight operations. For I & T purposes FlatSat will be a driver to development and dry run electrical integration procedures, STOL test procedures, page displays, and the command and telemetry database. FlatSat will also serve as a platform for flight software acceptance and systems testing for the flight software system component including the spacecraft main processors, power supply electronics, attitude control electronic, gimbal control electrons and the S-band communications card. FlatSat will also benefit the flight operations team through post-launch flight software code and table update development and verification and verification of new and updated flight operations products. This document highlights the benefits of FlatSat; describes the building of FlatSat; provides FlatSat facility requirements, access roles and responsibilities; and, and discusses FlatSat mechanical and electrical integration and functional testing.

Multi-Hazard Assessment of Scour Damaged Bridges with UAS-Based Measurements

NASA Astrophysics Data System (ADS)

Özcan, O.; Ozcan, O.

2017-12-01

Flood and stream induced scour occurring in bridge piers constructed on rivers is one of the mostly observed failure reasons in bridges. Scour induced failure risk in bridges and determination of the alterations in bridge safety under seismic effects has the ultimate importance. Thus, for the determination of bridge safety under the scour effects, the scour amount under bridge piers should be designated realistically and should be tracked and updated continuously. Hereby, the scour induced failures in bridge foundation systems will be prevented and bridge substructure design will be conducted safely. In this study, in order to measure the amount of scour in bridge load bearing system (pile foundations and pile abutments) and to attain very high definition 3 dimensional models of river flood plain for the flood analysis, unmanned aircraft system (UAS) based measurement methods were implemented. UAS based measurement systems provide new and practical approach and bring high precision and reliable solutions considering recent measurement systems. For this purpose, the reinforced concrete (RC) bridge that is located on Antalya Boğaçayı River, Turkey and that failed in 2003 due to flood-induced scour was selected as the case study. The amount of scour occurred in bridge piers and piles was determined realistically and the behavior of bridge piers under scour effects was investigated. Future flood effects and the resultant amount of scour was determined with HEC-RAS software by using digital surface models that were obtained at regular intervals using UAS for the riverbed. In the light of the attained scour measurements and expected scour after a probable flood event, the behavior of scour damaged RC bridge was investigated by pushover and time history analyses under lateral and vertical seismic loadings. In the analyses, the load and displacement capacity of bridge was observed to diminish significantly under expected scour. Thus, the deterioration in multi hazard performance of the bridge was monitored significantly in the light of updated bridge load bearing system capacity. Regarding the case study, UAS based and continuously updated bridge multi hazard risk detection system was established that can be used for bridges located on riverbed.

NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus. Supplement 4

NASA Technical Reports Server (NTRS)

2000-01-01

The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every six months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

Variations on the Game of Life

NASA Astrophysics Data System (ADS)

Peper, Ferdinand; Adachi, Susumu; Lee, Jia

The Game of Life is defined in the framework of Cellular Automata with discrete states that are updated synchronously. Though this in itself has proven to be fertile ground for research, it leaves open questions regarding the robustness of the model with respect to variations in updating methods, cell state representations, neighborhood definitions, etc. These questions may become important when the ideal conditions under which the Game of Life is supposed to operate cannot be satisfied, like in physical realizations. This chapter describes three models in which Game of Life-like behavior is obtained, even though some basic tenets are violated.

Differences and discrepancies between 2005 and 2008 Abbreviated Injury Scale versions - time to standardise

PubMed Central

2012-01-01

The aim of this letter is to facilitate the standardisation of Abbreviated Injury Scale (AIS) codesets used to code injuries in trauma registries. We have compiled a definitive list of the changes which have been implemented between the AIS 2005 and Update 2008 versions. While the AIS 2008 codeset appears to have remained consistent since its release, we have identified discrepancies between the codesets in copies of AIS 2005 dictionaries. As a result, we recommend that use of the AIS 2005 should be discontinued in favour of the Update 2008 version. PMID:22301065

Differences and discrepancies between 2005 and 2008 Abbreviated Injury Scale versions - time to standardise.

PubMed

Ringdal, Kjetil G; Hestnes, Morten; Palmer, Cameron S

2012-02-02

The aim of this letter is to facilitate the standardisation of Abbreviated Injury Scale (AIS) codesets used to code injuries in trauma registries. We have compiled a definitive list of the changes which have been implemented between the AIS 2005 and Update 2008 versions. While the AIS 2008 codeset appears to have remained consistent since its release, we have identified discrepancies between the codesets in copies of AIS 2005 dictionaries. As a result, we recommend that use of the AIS 2005 should be discontinued in favour of the Update 2008 version.

Experiment definition phase shuttle laboratory LDRL-10.6 experiment. [applying optical communication

NASA Technical Reports Server (NTRS)

1975-01-01

The 10.6 microns laser data relay link (LDRL 10.6) program was directed to applying optical communications to NASA's wideband data transmission requirements through the 1980's. The LDRL consists of a transmitter on one or more low earth orbit satellites with an elliptical orbit satellite receivers. Topics discussed include: update of the LDRL design control table to detail the transmitter optical chain losses and to incorporate the change to a reflective beam pre-expander; continued examination of the link establishment sequence, including its dependence upon spacecraft stability; design of the transmitter pointing and tracking control system; and finalization of the transmitter brassboard optical and mechanical design.

Business process modeling in healthcare.

PubMed

Ruiz, Francisco; Garcia, Felix; Calahorra, Luis; Llorente, César; Gonçalves, Luis; Daniel, Christel; Blobel, Bernd

2012-01-01

The importance of the process point of view is not restricted to a specific enterprise sector. In the field of health, as a result of the nature of the service offered, health institutions' processes are also the basis for decision making which is focused on achieving their objective of providing quality medical assistance. In this chapter the application of business process modelling - using the Business Process Modelling Notation (BPMN) standard is described. Main challenges of business process modelling in healthcare are the definition of healthcare processes, the multi-disciplinary nature of healthcare, the flexibility and variability of the activities involved in health care processes, the need of interoperability between multiple information systems, and the continuous updating of scientific knowledge in healthcare.

The Large UV/Optical/Infrared Surveyor (LUVOIR): Decadal Mission concept design update

NASA Astrophysics Data System (ADS)

Bolcar, Matthew R.; Aloezos, Steve; Bly, Vincent T.; Collins, Christine; Crooke, Julie; Dressing, Courtney D.; Fantano, Lou; Feinberg, Lee D.; France, Kevin; Gochar, Gene; Gong, Qian; Hylan, Jason E.; Jones, Andrew; Linares, Irving; Postman, Marc; Pueyo, Laurent; Roberge, Aki; Sacks, Lia; Tompkins, Steven; West, Garrett

2017-09-01

In preparation for the 2020 Astrophysics Decadal Survey, NASA has commissioned the study of four large mission concepts, including the Large Ultraviolet / Optical / Infrared (LUVOIR) Surveyor. The LUVOIR Science and Technology Definition Team (STDT) has identified a broad range of science objectives including the direct imaging and spectral characterization of habitable exoplanets around sun-like stars, the study of galaxy formation and evolution, the epoch of reionization, star and planet formation, and the remote sensing of Solar System bodies. NASA's Goddard Space Flight Center (GSFC) is providing the design and engineering support to develop executable and feasible mission concepts that are capable of the identified science objectives. We present an update on the first of two architectures being studied: a 15- meter-diameter segmented-aperture telescope with a suite of serviceable instruments operating over a range of wavelengths between 100 nm to 2.5 μm. Four instruments are being developed for this architecture: an optical / near-infrared coronagraph capable of 10-10 contrast at inner working angles as small as 2 λ/D the LUVOIR UV Multi-object Spectrograph (LUMOS), which will provide low- and medium-resolution UV (100 - 400 nm) multi-object imaging spectroscopy in addition to far-UV imaging; the High Definition Imager (HDI), a high-resolution wide-field-of-view NUV-Optical-IR imager; and a UV spectro-polarimeter being contributed by Centre National d'Etudes Spatiales (CNES). A fifth instrument, a multi-resolution optical-NIR spectrograph, is planned as part of a second architecture to be studied in late 2017.

Multicultural Counseling Competencies, 2003: Association for Multicultural Counseling and Development.

ERIC Educational Resources Information Center

Roysircar, Gargi; Arredondo, Patricia; Fuertes, Jairo N.; Ponterotto, Joseph G.; Toporek, Rebecca L.

This book updates earlier Association for Multicultural Counseling and Development (AMCD) multicultural counseling competencies (MCC). Each chapter author particularizes definitions and/or conceptualizations of multicultural competencies to the topic of his or her chapter. The present document operationalizes the MCC into practice examples,…

42 CFR 424.502 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... officer, general partner, chairman of the board, or direct owner) to whom the organization has granted the legal authority to enroll it in the Medicare program, to make changes or updates to the organization's status in the Medicare program, and to commit the organization to fully abide by the statutes...

State Laws for RTI: An Updated Snapshot

ERIC Educational Resources Information Center

Zirkel, Perry A.; Thomas, Lisa B.

2010-01-01

Professionally, and ultimately legally, the definition of "specific learning disabilities" (SLD) has been "a long-standing source of controversy, conflict, and crisis." Yet students with SLD continue to be more numerous by far than any other group receiving special education services. The long-time controversy concerning the…

A Human Rights Glossary.

ERIC Educational Resources Information Center

Flowers, Nancy

1998-01-01

Presents a human rights glossary that includes definitions of basic terms, treaties, charters, and groups/organizations that have been featured in previous articles in this edition of "Update on Law-Related Education"; the human rights terms have been compiled as part of the celebration of the Universal Declaration of Human Rights…

Data Literacy is Statistical Literacy

ERIC Educational Resources Information Center

Gould, Robert

2017-01-01

Past definitions of statistical literacy should be updated in order to account for the greatly amplified role that data now play in our lives. Experience working with high-school students in an innovative data science curriculum has shown that teaching statistical literacy, augmented by data literacy, can begin early.

RCRA, Superfund and EPCRA hotline training module. Introduction to: the Superfund response program (updated February 1998); Directive

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-06-01

This module includes the following: Regulatory Summary (Definitions; National Contingency Plan; Notification or Discovery; Response Process; Removal Process; Remedial Process; Community Involvement; State Role; Natural Resource Damage Assessments; Federal Facility Response; and Contractor Support); and Module Summary.

Training Manager Competencies: The Standards. Third Edition.

ERIC Educational Resources Information Center

Foxon, Marguerite; Richey, Rita C.; Roberts, Robert C.; Spannaus, Timothy W.

In this third edition of "Training Manager Competencies: The Standards," the International Board of Standards for Training, Performance and Instruction (IBSTPI) presents an updated definition and discussion of the competencies of training managers. It is an expanded view that reflects the complexities and pressures of current practice…

7 CFR 3430.602 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

...-GENERAL AWARD ADMINISTRATIVE PROVISIONS Beginning Farmer and Rancher Development Program § 3430.602... year, based on the October 2002 Prices Paid by Farmer Index compiled and updated annually by the USDA... the previous 2 years as determined by the U.S. Department of Health and Human Services (DHHS), using...

Alternative Teacher Certification--An Update. ERIC Digest.

ERIC Educational Resources Information Center

Otuya, Ebo

This digest reviews alternative certification on the basis of educational quality and the need to fill teacher shortages. Following a definition of traditional certification, the alternative certification route is described as a process designed to certify candidates who have subject-matter competencies, without going through formal teacher…

Information management system breadboard data acquisition and control system.

NASA Technical Reports Server (NTRS)

Mallary, W. E.

1972-01-01

Description of a breadboard configuration of an advanced information management system based on requirements for high data rates and local and centralized computation for subsystems and experiments to be housed on a space station. The system is to contain a 10-megabit-per-second digital data bus, remote terminals with preprocessor capabilities, and a central multiprocessor. A concept definition is presented for the data acquisition and control system breadboard, and a detailed account is given of the operation of the bus control unit, the bus itself, and the remote acquisition and control unit. The data bus control unit is capable of operating under control of both its own test panel and the test processor. In either mode it is capable of both single- and multiple-message operation in that it can accept a block of data requests or update commands for transmission to the remote acquisition and control unit, which in turn is capable of three levels of data-handling complexity.

Medicare program; end-stage renal disease prospective payment system, quality incentive program, and durable medical equipment, prosthetics, orthotics, and supplies.

PubMed

2013-12-02

This rule updates and makes revisions to the End-Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2014. This rule also sets forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2016 and beyond. In addition, this rule clarifies the grandfathering provision related to the 3-year minimum lifetime requirement (MLR) for Durable Medical Equipment (DME), and provides clarification of the definition of routinely purchased DME. This rule also implements budget-neutral fee schedules for splints and casts, and intraocular lenses (IOLs) inserted in a physician's office. Finally, this rule makes a few technical amendments and corrections to existing regulations related to payment for durable medical equipment, prosthetics, orthotics, and supplies (DMEPOS) items and services.

Polycystic ovary syndrome: update on diagnosis and treatment.

PubMed

Setji, Tracy L; Brown, Ann J

2014-10-01

Polycystic ovary syndrome is now a well-recognized condition affecting 6%-25% of reproductive-aged women, depending on the definition. Over the past 3 decades, research has launched it from relative medical obscurity to a condition increasingly recognized as common in internal medicine practices. It affects multiple systems, and requires a comprehensive perspective on health care for effective treatment. Metabolic derangements and associated complications include insulin resistance and diabetes, hyperlipidemia, hypertension, fatty liver, metabolic syndrome, and sleep apnea. Reproductive complications include oligo-/amenorrhea, sub-fertility, endometrial hyperplasia, and cancer. Associated psychosocial concerns include depression and disordered eating. Additionally, cosmetic issues include hirsutism, androgenic alopecia, and acne. This review organizes this multi-system approach around the mnemonic "MY PCOS" and discusses evaluation and treatment options for the reproductive, cosmetic, and metabolic complications of this condition. Copyright © 2014 Elsevier Inc. All rights reserved.

78 FR 40835 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-08

...This rule proposes to update and make revisions to the End- Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2014. This rule also proposes to set forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2016 and beyond. In addition, this rule proposes to clarify the grandfathering provision related to the 3-year minimum lifetime requirement (MLR) for Durable Medical Equipment (DME). In addition, it provides clarification of the definition of routinely purchased DME. This rule also proposes the implementation of budget- neutral fee schedules for splints and casts, and intraocular lenses (IOLs) inserted in a physician's office. Finally, this rule would make a few technical amendments and corrections to existing regulations related to payment for DMEPOS items and services.

An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation.

PubMed

Spruit, Martijn A; Singh, Sally J; Garvey, Chris; ZuWallack, Richard; Nici, Linda; Rochester, Carolyn; Hill, Kylie; Holland, Anne E; Lareau, Suzanne C; Man, William D-C; Pitta, Fabio; Sewell, Louise; Raskin, Jonathan; Bourbeau, Jean; Crouch, Rebecca; Franssen, Frits M E; Casaburi, Richard; Vercoulen, Jan H; Vogiatzis, Ioannis; Gosselink, Rik; Clini, Enrico M; Effing, Tanja W; Maltais, François; van der Palen, Job; Troosters, Thierry; Janssen, Daisy J A; Collins, Eileen; Garcia-Aymerich, Judith; Brooks, Dina; Fahy, Bonnie F; Puhan, Milo A; Hoogendoorn, Martine; Garrod, Rachel; Schols, Annemie M W J; Carlin, Brian; Benzo, Roberto; Meek, Paula; Morgan, Mike; Rutten-van Mölken, Maureen P M H; Ries, Andrew L; Make, Barry; Goldstein, Roger S; Dowson, Claire A; Brozek, Jan L; Donner, Claudio F; Wouters, Emiel F M

2013-10-15

Pulmonary rehabilitation is recognized as a core component of the management of individuals with chronic respiratory disease. Since the 2006 American Thoracic Society (ATS)/European Respiratory Society (ERS) Statement on Pulmonary Rehabilitation, there has been considerable growth in our knowledge of its efficacy and scope. The purpose of this Statement is to update the 2006 document, including a new definition of pulmonary rehabilitation and highlighting key concepts and major advances in the field. A multidisciplinary committee of experts representing the ATS Pulmonary Rehabilitation Assembly and the ERS Scientific Group 01.02, "Rehabilitation and Chronic Care," determined the overall scope of this update through group consensus. Focused literature reviews in key topic areas were conducted by committee members with relevant clinical and scientific expertise. The final content of this Statement was agreed on by all members. An updated definition of pulmonary rehabilitation is proposed. New data are presented on the science and application of pulmonary rehabilitation, including its effectiveness in acutely ill individuals with chronic obstructive pulmonary disease, and in individuals with other chronic respiratory diseases. The important role of pulmonary rehabilitation in chronic disease management is highlighted. In addition, the role of health behavior change in optimizing and maintaining benefits is discussed. The considerable growth in the science and application of pulmonary rehabilitation since 2006 adds further support for its efficacy in a wide range of individuals with chronic respiratory disease.

Neuropathic pain: an updated grading system for research and clinical practice

PubMed Central

Finnerup, Nanna B.; Haroutounian, Simon; Kamerman, Peter; Baron, Ralf; Bennett, David L.H.; Bouhassira, Didier; Cruccu, Giorgio; Freeman, Roy; Hansson, Per; Nurmikko, Turo; Raja, Srinivasa N.; Rice, Andrew S.C.; Serra, Jordi; Smith, Blair H.; Treede, Rolf-Detlef; Jensen, Troels S.

2016-01-01

Abstract The redefinition of neuropathic pain as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system,” which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast, the proposed grading system of possible, probable, and definite neuropathic pain from 2008 has been used to a lesser extent. Here, we report a citation analysis of the original NeuPSIG grading paper of 2008, followed by an analysis of its use by an expert panel and recommendations for an improved grading system. As of February, 2015, 608 eligible articles in Scopus cited the paper, 414 of which cited the neuropathic pain definition. Of 220 clinical studies citing the paper, 56 had used the grading system. The percentage using the grading system increased from 5% in 2009 to 30% in 2014. Obstacles to a wider use of the grading system were identified, including (1) questions about the relative significance of confirmatory tests, (2) the role of screening tools, and (3) uncertainties about what is considered a neuroanatomically plausible pain distribution. Here, we present a revised grading system with an adjusted order, better reflecting clinical practice, improvements in the specifications, and a word of caution that even the “definite” level of neuropathic pain does not always indicate causality. In addition, we add a table illustrating the area of pain and sensory abnormalities in common neuropathic pain conditions and propose areas for further research. PMID:27115670

49 CFR 563.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... function in a vehicle that records the vehicle's dynamic time-series data during the time period just prior... updated at regular time intervals. Delta-V, lateral means the cumulative change in velocity, as recorded by the EDR of the vehicle, along the lateral axis, starting from crash time zero and ending at 0.25...

49 CFR 563.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... function in a vehicle that records the vehicle's dynamic time-series data during the time period just prior... updated at regular time intervals. Delta-V, lateral means the cumulative change in velocity, as recorded by the EDR of the vehicle, along the lateral axis, starting from crash time zero and ending at 0.25...

State SLD Identification Policies and Practices

ERIC Educational Resources Information Center

Reschly, Daniel J.; Hosp, John L.

2004-01-01

Specific learning disabilities (SLD) conceptual definitions and classification criteria were examined through a survey of state education agency (SEA) SLD contact persons in an effort to update information last published in 1996. Most prior trends continued over the last decade. Results showed that SEA SLD classification criteria continue to be…

78 FR 25181 - Revision of Regulations Defining Bona Fide Cotton Spot Markets

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

...-AD26 Revision of Regulations Defining Bona Fide Cotton Spot Markets AGENCY: Agricultural Marketing... regulation that specifies which states compose bona fide cotton spot markets in order to assure consistency with the revised Cotton Research and Promotion Act. Updated bona fide spot market definitions allow for...

78 FR 59666 - Transmission Infrastructure Program; Proposed Transmission Infrastructure Program Updates and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-27

... Loan Programs Office into the process. The FRN also identifies the principles Western will continue using to ensure (1) that the Program is separate and distinct from Western's power marketing functions... obtain project funding. Table of Contents I. Definitions II. Principles III. Project Evaluation Criteria...

Internationalization Remodeled: Definition, Approaches, and Rationales

ERIC Educational Resources Information Center

Knight, Jane

2004-01-01

The world of higher education is changing and the world in which higher education plays a significant role is changing. The international dimension of higher education is becoming increasingly important, complex, and confusing. It is therefore timely to reexamine and update the conceptual frameworks underpinning the notion of inter-nationalization…

78 FR 29116 - North Pacific Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

... BOF state water groundfish fishery proposals; Update on definition of a fishing guide and coordination....noaa.gov/npfmc/ . Although non-emergency issues not contained in this agenda may come before this group... publication of this notice that require emergency action under section 305(c) of the Magnuson-Stevens Fishery...

49 CFR 563.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... function in a vehicle that records the vehicle's dynamic time-series data during the time period just prior... updated at regular time intervals. Delta-V, lateral means the cumulative change in velocity, as recorded by the EDR of the vehicle, along the lateral axis, starting from crash time zero and ending at 0.25...

10 CFR 72.48 - Changes, tests, and experiments.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Changes, tests, and experiments. 72.48 Section 72.48... Issuance and Conditions of License § 72.48 Changes, tests, and experiments. (a) Definitions for the... times). (7) Tests or experiments not described in the Final Safety Analysis Report (as updated) means...

10 CFR 72.48 - Changes, tests, and experiments.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Changes, tests, and experiments. 72.48 Section 72.48... Issuance and Conditions of License § 72.48 Changes, tests, and experiments. (a) Definitions for the... times). (7) Tests or experiments not described in the Final Safety Analysis Report (as updated) means...

10 CFR 72.48 - Changes, tests, and experiments.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Changes, tests, and experiments. 72.48 Section 72.48... Issuance and Conditions of License § 72.48 Changes, tests, and experiments. (a) Definitions for the... times). (7) Tests or experiments not described in the Final Safety Analysis Report (as updated) means...

The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms.

PubMed

Matutes, E

2018-05-01

Over the last decade, there has been a significant body of information regarding the biology of the lymphoid neoplasms. This clearly supports the need for updating the 2008 WHO (World Health Organization) classification of haematopoietic and lymphoid tumours. The 2017 WHO classification is not a new edition but an update and revision of the 4th edition. New provisional entities but not new definitive entities are included, and novel molecular data in most of the entities and changes in the nomenclature in few of them have been incorporated. In the context of the mature T- and NK-cell neoplasms, the most relevant updates concern to: 1-dysregulation of the JAK/STAT pathway due to gene mutations which are common to various aggressive and indolent neoplasms; 2-incorporation of new molecular players that are relevant to the pathogenesis of these neoplasms and/or have prognostic implications; 3-inclusion of new provisional entities within the subgroups of anaplastic, primarily intestinal and cutaneous lymphomas such as breast implant-associated anaplastic large cell lymphoma, indolent T-cell lymphoproliferative disorder of the gastrointestinal tract and primary cutaneous acral CD8 + T-cell lymphoma; 4-identification of poor prognostic subtypes of peripheral T-cell lymphomas not otherwise specified (PTCL, NOS) characterized by overexpression of certain genes and of a subgroup PTCL, NOS with a T follicular phenotype that now is included together with angioimmunoblastic T-cell lymphoma under the umbrella of lymphomas with a T follicular helper phenotype; and 5-refinement on the designation and definition of already established entities. A review of the major changes will be outlined. © 2018 John Wiley & Sons Ltd.

An Online Risk Monitor System (ORMS) to Increase Safety and Security Levels in Industry

NASA Astrophysics Data System (ADS)

Zubair, M.; Rahman, Khalil Ur; Hassan, Mehmood Ul

2013-12-01

The main idea of this research is to develop an Online Risk Monitor System (ORMS) based on Living Probabilistic Safety Assessment (LPSA). The article highlights the essential features and functions of ORMS. The basic models and modules such as, Reliability Data Update Model (RDUM), running time update, redundant system unavailability update, Engineered Safety Features (ESF) unavailability update and general system update have been described in this study. ORMS not only provides quantitative analysis but also highlights qualitative aspects of risk measures. ORMS is capable of automatically updating the online risk models and reliability parameters of equipment. ORMS can support in the decision making process of operators and managers in Nuclear Power Plants.

Development of Monte Carlo simulations to provide scanner-specific organ dose coefficients for contemporary CT

NASA Astrophysics Data System (ADS)

Jansen, Jan T. M.; Shrimpton, Paul C.

2016-07-01

The ImPACT (imaging performance assessment of CT scanners) CT patient dosimetry calculator is still used world-wide to estimate organ and effective doses (E) for computed tomography (CT) examinations, although the tool is based on Monte Carlo calculations reflecting practice in the early 1990’s. Subsequent developments in CT scanners, definitions of E, anthropomorphic phantoms, computers and radiation transport codes, have all fuelled an urgent need for updated organ dose conversion factors for contemporary CT. A new system for such simulations has been developed and satisfactorily tested. Benchmark comparisons of normalised organ doses presently derived for three old scanners (General Electric 9800, Philips Tomoscan LX and Siemens Somatom DRH) are within 5% of published values. Moreover, calculated normalised values of CT Dose Index for these scanners are in reasonable agreement (within measurement and computational uncertainties of  ±6% and  ±1%, respectively) with reported standard measurements. Organ dose coefficients calculated for a contemporary CT scanner (Siemens Somatom Sensation 16) demonstrate potential deviations by up to around 30% from the surrogate values presently assumed (through a scanner matching process) when using the ImPACT CT Dosimetry tool for newer scanners. Also, illustrative estimates of E for some typical examinations and a range of anthropomorphic phantoms demonstrate the significant differences (by some 10’s of percent) that can arise when changing from the previously adopted stylised mathematical phantom to the voxel phantoms presently recommended by the International Commission on Radiological Protection (ICRP), and when following the 2007 ICRP recommendations (updated from 1990) concerning tissue weighting factors. Further simulations with the validated dosimetry system will provide updated series of dose coefficients for a wide range of contemporary scanners.

77 FR 49063 - Energy Conservation Program: Test Procedures for Residential Dishwashers and Cooking Products

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

...The U.S. Department of Energy (DOE) proposes to amend its test procedures for residential dishwashers to update certain obsolete dishware, flatware and food items, make minor amendments to the definition of the normal cycle, and update the ambient temperature and preconditioning requirements as well as the industry test method referenced in DOE's test procedure. DOE also proposes to add water pressure, drain height, rack position, loading, rinse aid container, and soil preparation specifications to the dishwasher test procedure. DOE additionally proposes to amend the test procedures for both dishwashers and conventional cooking products for the measurement of energy use in fan-only mode.

NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus. Supplement 5

NASA Technical Reports Server (NTRS)

2000-01-01

The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every 6 months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition of the NASA Thesaurus. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus. Supplement 7

NASA Technical Reports Server (NTRS)

2001-01-01

The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every six months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition of the NASA Thesaurus. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus

NASA Technical Reports Server (NTRS)

2001-01-01

The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every six months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition of the NASA Thesaurus. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

Status Update on Translation of Integrated Primary Dental-Medical Care Delivery for Management of Diabetic Patients.

PubMed

Glurich, Ingrid; Nycz, Gregory; Acharya, Amit

2017-06-01

Escalating prevalence of both diabetes and periodontal disease, two diseases associated with bi-directional exacerbation, has been reported. Periodontal disease represents a modifiable risk factor that may reduce diabetes onset or progression, and integrated models of cross-disciplinary care are needed to establish and manage glycemic control in affected patients. An ad-hoc environmental scan of current literature and media sought to characterize factors impacting status of integrated care models based on review of the existing evidence base in literature and media surrounding: (1) current cross-disciplinary practice patterns, (2) epidemiological updates, (3) status on risk assessment and screening for dysglycemia in the dental setting, (4) status on implementation of quality metrics for oral health, (5) care model pilots, and (6) public health perspectives. The survey revealed: escalating prevalence of diabetes and periodontitis globally; greater emphasis on oral health assessment for diabetic patients in recent medical clinical practice guidelines; high knowledgeability surrounding oral-systemic impacts on diabetes and growing receptivity to medical-dental integration among medical and dental providers; increasing numbers of programs/studies reporting on positive impact of emerging integrated dental-medical care models on diabetic patient healthcare access and health outcomes; a growing evidence base for clinically significant rates of undiagnosed dysglycemia among dental patients reported by point-of-care pilot studies; no current recommendation for population-based screening for dysglycemia in dental settings pending a stronger evidence base; improved definition of true periodontitis prevalence in (pre)/diabetics; emerging recognition of the need for oral health quality indicators and tracking; evidence of persistence in dental access disparity; updated status on barriers to integration. The potential benefit of creating clinically-applicable integrated care models to support holistic management of an escalating diabetic population by targeting modifiable risk factors including periodontitis is being recognized by the health industry. Cross-disciplinary efforts supported by high quality research are needed to mitigate previously- and newly-defined barriers of care integration and expedite development and implementation of integrated care models in various practice settings. Implementation of quality monitoring in the dental setting will support definition of the impact and efficacy of interventional clinical care models on patient outcomes. © 2017 Marshfield Clinic.

New temperature model of the Netherlands from new data and novel modelling methodology

NASA Astrophysics Data System (ADS)

Bonté, Damien; Struijk, Maartje; Békési, Eszter; Cloetingh, Sierd; van Wees, Jan-Diederik

2017-04-01

Deep geothermal energy has grown in interest in Western Europe in the last decades, for direct use but also, as the knowledge of the subsurface improves, for electricity generation. In the Netherlands, where the sector took off with the first system in 2005, geothermal energy is seen has a key player for a sustainable future. The knowledge of the temperature subsurface, together with the available flow from the reservoir, is an important factor that can determine the success of a geothermal energy project. To support the development of deep geothermal energy system in the Netherlands, we have made a first assessment of the subsurface temperature based on thermal data but also on geological elements (Bonté et al, 2012). An outcome of this work was ThermoGIS that uses the temperature model. This work is a revision of the model that is used in ThermoGIS. The improvement from the first model are multiple, we have been improving not only the dataset used for the calibration and structural model, but also the methodology trough an improved software (called b3t). The temperature dataset has been updated by integrating temperature on the newly accessible wells. The sedimentary description in the basin has been improved by using an updated and refined structural model and an improved lithological definition. A major improvement in from the methodology used to perform the modelling, with b3t the calibration is made not only using the lithospheric parameters but also using the thermal conductivity of the sediments. The result is a much more accurate definition of the parameters for the model and a perfected handling of the calibration process. The result obtain is a precise and improved temperature model of the Netherlands. The thermal conductivity variation in the sediments associated with geometry of the layers is an important factor of temperature variations and the influence of the Zechtein salt in the north of the country is important. In addition, the radiogenic heat production in the crust shows a significant impact. From the temperature values, also identify in the lower part of the basin, deep convective systems that could be major geothermal energy target in the future.

Status Report on Activities of the Systems Assessment Task Force, OECD-NEA Expert Group on Accident Tolerant Fuels for LWRs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bragg-Sitton, Shannon Michelle

The Organization for Economic Cooperation and Development /Nuclear Energy Agency (OECD/NEA) Nuclear Science Committee approved the formation of an Expert Group on Accident Tolerant Fuel (ATF) for LWRs (EGATFL) in 2014. Chaired by Kemal Pasamehmetoglu, INL Associate Laboratory Director for Nuclear Science and Technology, the mandate for the EGATFL defines work under three task forces: (1) Systems Assessment, (2) Cladding and Core Materials, and (3) Fuel Concepts. Scope for the Systems Assessment task force (TF1) includes definition of evaluation metrics for ATF, technology readiness level definition, definition of illustrative scenarios for ATF evaluation, and identification of fuel performance and systemmore » codes applicable to ATF evaluation. The Cladding and Core Materials (TF2) and Fuel Concepts (TF3) task forces will identify gaps and needs for modeling and experimental demonstration; define key properties of interest; identify the data necessary to perform concept evaluation under normal conditions and illustrative scenarios; identify available infrastructure (internationally) to support experimental needs; and make recommendations on priorities. Where possible, considering proprietary and other export restrictions (e.g., International Traffic in Arms Regulations), the Expert Group will facilitate the sharing of data and lessons learned across the international group membership. The Systems Assessment task force is chaired by Shannon Bragg-Sitton (Idaho National Laboratory [INL], U.S.), the Cladding Task Force is chaired by Marie Moatti (Electricite de France [EdF], France), and the Fuels Task Force is chaired by a Masaki Kurata (Japan Atomic Energy Agency [JAEA], Japan). The original Expert Group mandate was established for June 2014 to June 2016. In April 2016 the Expert Group voted to extend the mandate one additional year to June 2017 in order to complete the task force deliverables; this request was subsequently approved by the Nuclear Science Committee. This report provides an update on the status Systems Assessment Task Force activities.« less

Diagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016).

PubMed

Mancini, G B John; Baker, Steven; Bergeron, Jean; Fitchett, David; Frohlich, Jiri; Genest, Jacques; Gupta, Milan; Hegele, Robert A; Ng, Dominic; Pearson, Glen J; Pope, Janet; Tashakkor, A Yashar

2016-07-01

The Canadian Consensus Working Group has updated its evaluation of the literature pertaining to statin intolerance and adverse effects. This overview introduces a pragmatic definition of statin intolerance (goal-inhibiting statin intolerance) that emphasizes the effects of symptoms on achieving nationally vetted goals in patients fulfilling indications for lipid-lowering therapy and cardiovascular risk reduction. The Canadian Consensus Working Group provides a structured framework for avoiding, evaluating and managing goal-inhibiting statin intolerance. Particularly difficult practice situations are reviewed, including management in young and elderly individuals, and in athletes and labourers. Finally, targeted at specialty practitioners, more detailed analyses of specific but more unusual adverse effects ascribed to statins are updated including evidence regarding new-onset diabetes, cognitive dysfunction, cataracts, and the rare but important immune-mediated necrotizing myopathy. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

77 FR 31443 - Energy Conservation Program: Test Procedures for Residential Dishwashers, Dehumidifiers, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... dishwashers with a separate soil- sensing cycle, and the normal cycle definition, power supply and detergent... Soiling Requirements 5. Detergent Dosing Specifications E. Incorporation by Reference of an Updated AHAM...: (1) The addition of a method to rate the efficiency of soil-sensing products; (2) the addition of a...

49 CFR 563.5 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... dynamic time-series data during the time period just prior to a crash event (e.g., vehicle speed vs. time... EDR data in a temporary, volatile storage medium where it is continuously updated at regular time..., along the lateral axis, starting from crash time zero and ending at 0.25 seconds, recorded every 0.01...

49 CFR 563.5 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... vehicle's dynamic time-series data during the time period just prior to a crash event (e.g., vehicle speed... updated at regular time intervals. Delta-V, lateral means the cumulative change in velocity, as recorded by the EDR of the vehicle, along the lateral axis, starting from crash time zero and ending at 0.25...

Statistics of Public Libraries, 1977-1978.

ERIC Educational Resources Information Center

Eckard, Helen

Based on a study of U.S. public libraries which was part of the 1977-78 Library General Information Survey (LIBGIS), this statistical report updates a similar 1974 publication. A definition of public libraries as used in the survey is provided, as well as information on public library service outlets, equipment, staffing, receipts, expenditures,…

Adult Literacy Issues, Programs, and Options. Updated.

ERIC Educational Resources Information Center

Irwin, Paul M.

Media reports suggest widespread illiteracy among adults who may not be able to read, write, speak, or otherwise communicate competently enough to meet the demands of modern society. There is no consensus on the definition of illiteracy or supporting statistics. According to the U.S. Department of Education, the adult illiteracy rate is 13…

Merit Pay Plans for Teachers: Status and Descriptions. ERS Report.

ERIC Educational Resources Information Center

Educational Research Service, Arlington, VA.

This report, an update of the 1978 survey of national merit pay plans for teachers, provides descriptive data on currently operating merit pay plans and state level activities. Outlining current research, the report points out that neither a commonly acceptable definition of merit pay nor a generally acceptable method of determining meritorious…

Information Literacy: Essential Skills for the Information Age, Second Edition

ERIC Educational Resources Information Center

Eisenberg, Michael B.; Lowe, Carrie A.; Spitzer, Kathleen L.

2004-01-01

This is the definitive work on information literacy. Michael Eisenberg, known worldwide as one of the originators of the innovative Big6 Information Problem Solving Process, and frequent presenters on the subject Carrie A. Lowe and Kathleen L. Spitzer have extensively revised and updated this long-awaited second edition. Tracing the history of…

76 FR 26192 - Revisions to the California State Implementation Plan, Northern Sonoma County Air Pollution...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-06

...-approved Prevention of Significant Deterioration (PSD) permit programs. These revisions update the definitions used in the districts' PSD permit programs. DATES: This rule is effective on July 5, 2011 without... Deterioration (PSD) permit program. Both the NSCAPCD and MCAQMD are currently designated as attainment or...

75 FR 53202 - Diseases Associated With Exposure to Certain Herbicide Agents (Hairy Cell Leukemia and Other...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... disorders. VA Response: Update 2008 only evaluated the correlation between certain herbicide exposure and... contain any descriptive definition of IHD; therefore, it does not provide any additional assistance to... medical studies that show a correlation between exposure to herbicides and ischemic heart disease. As we...

School Officials and the Courts: Update 1985. ERS Monograph.

ERIC Educational Resources Information Center

Beckham, Joseph C.

Cases involving public elementary and secondary education that were decided in state and federal courts from July 1984 to June 1985 are summarized in this review. The cases were selected on the basis of their relevance to contemporary problems in public schools, their definitiveness as articulations of existing law, and their reliability as guides…

An Analysis of State Guidelines for Intellectual Disability

ERIC Educational Resources Information Center

Polloway, Edward A.; Auguste, Maryleen; Smith, J. David; Peters, Delia

2017-01-01

This study provides an updated analysis of state guidelines with respect to terminology and definitions in the field of intellectual disability (ID). The study serves as a methodological replication of prior work that has been reported in the literature in earlier decades. The data were acquired by reviewing web-based state guidelines for ID…

Updating Rurality Index for Small Areas in Spain

ERIC Educational Resources Information Center

Prieto-Lara, Elisa; Ocana-Riola, Ricardo

2010-01-01

Nowadays, there is a wide debate about what rural means. An operational definition of rural concept is essential in order to measure health problems, optimize resource allocation and facilitate decision making aimed at closing the gap on inequity between areas. In 2005, the rurality index for Small Areas in Spain (IRAP) was developed using the…

76 FR 35787 - Updated Trafficking Definition and Supplemental Nutrition Assistance Program (SNAP)-FDPIR Dual...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

... their race, color, national origin, sex, age, disability, religion or political belief nor will it have... that discriminate based on race, color, national origin, sex, age, disability, religion, or political..., national origin, gender, age, disability, marital or family status. Regulations at 7 CFR 272.6 specifically...

Space transportation booster engine configuration study. Addendum: Design definition document

NASA Technical Reports Server (NTRS)

1989-01-01

Gas generator engine characteristics and results of engine configuration refinements are discussed. Updated component mechanical design, performance, and manufacturing information is provided. The results are also provided of ocean recovery studies and various engine integration tasks. The details are provided of the maintenance plan for the Space Transportation Booster Engine.

Family Therapy for Drug Abuse: Review and Updates 2003-2010

ERIC Educational Resources Information Center

Rowe, Cynthia L.

2012-01-01

Just 15 years ago, Liddle and Dakof ("Journal of Marital and Family Therapy," 1995; 21, 511) concluded, based on the available evidence, that family therapy represented a "promising, but not definitive" approach for the treatment of drug problems among adolescents and adults. Seven years later, Rowe and Liddle (2003) review described considerable…

76 FR 30338 - Hill-Lake Gas Storage, LLC; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-110-000] Hill-Lake Gas Storage, LLC; Notice of Filing Take notice that on May 13, 2011, Hill-Lake Gas Storage, LLC filed to update its address and to clarify definitions for Maximum Daily Withdrawal Quantity and Maximum Daily...

Communication Services and Supports for Individuals with Severe Disabilities: Guidance for Assessment and Intervention

ERIC Educational Resources Information Center

Brady, Nancy C.; Bruce, Susan; Goldman, Amy; Erickson, Karen; Mineo, Beth; Ogletree, Bill T.; Paul, Diane; Romski, Mary Ann; Sevcik, Rose; Siegel, Ellin; Schoonover, Judith; Snell, Marti; Sylvester, Lorraine; Wilkinson, Krista

2016-01-01

The National Joint Committee for the Communication Needs of People With Severe Disabilities (NJC) reviewed literature regarding practices for people with severe disabilities in order to update guidance provided in documents originally published in 1992. Changes in laws, definitions, and policies that affect communication attainments by persons…

77 FR 24427 - Standards for Business Practices and Communication Protocols for Public Utilities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... equipment to produce the same level of end-use services (e.g. lighting, heating, motor drive) with less... also include updates to certain associated definitions as well as some formatting and organizational... first part establishes criteria for the use of equipment, technology, and procedures to quantify the...

World Trends and Issues in Adult Literacy: Update, 1990.

ERIC Educational Resources Information Center

Bhola, H. S.

Some of the trends and issues in worldwide adult literacy include the existence of the following: (1) an increasing percentage of literate people, perhaps resulting from more children's education rather than literacy initiatives for adults; (2) fuzzy definitions of literacy and inaccurate self-reported data; (3) a change in ideology, moving from…

26 CFR 1.36B-1 - Premium tax credit definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... meaning as in 45 CFR 155.20. (h) Federal poverty line. The Federal poverty line means the most recently published poverty guidelines (updated periodically in the Federal Register by the Secretary of Health and... Federal poverty line for computing the premium tax credit for a taxable year is the Federal poverty line...

26 CFR 1.36B-1 - Premium tax credit definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... meaning as in 45 CFR 155.20. (h) Federal poverty line. The Federal poverty line means the most recently published poverty guidelines (updated periodically in the Federal Register by the Secretary of Health and... Federal poverty line for computing the premium tax credit for a taxable year is the Federal poverty line...

42 CFR 435.4 - Definitions and use of terms.

Code of Federal Regulations, 2013 CFR

2013-10-01

... relative, even after the marriage is terminated by death or divorce. (3) At State option, another relative... poverty level (FPL) means the Federal poverty level updated periodically in the Federal Register by the... income at or below 200 percent of the Federal poverty line for a family of the size involved; and (ii...

42 CFR 435.4 - Definitions and use of terms.

Code of Federal Regulations, 2014 CFR

2014-10-01

... relative, even after the marriage is terminated by death or divorce. (3) At State option, another relative... poverty level (FPL) means the Federal poverty level updated periodically in the Federal Register by the... income at or below 200 percent of the Federal poverty line for a family of the size involved; and (ii...

78 FR 11967 - Supplemental Nutrition Assistance Program (SNAP): Updated Trafficking Definition and Supplemental...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... disqualification of a SNAP client who intentionally obtains cash by purchasing, with SNAP benefits, products that... exchange for cash refund of deposit(s); or who intentionally resells or exchanges products purchased with... the SNAP client. Examples of the latter would be the purchase, by retailers, of products originally...

10 CFR 63.44 - Changes, tests, and experiments.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Changes, tests, and experiments. 63.44 Section 63.44... experiments. (a) Definitions for the purposes of this section: (1) Change means a modification or addition to... isolation, are operated or controlled. (6) Tests or experiments not described in the SAR (as updated) means...

10 CFR 63.44 - Changes, tests, and experiments.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Changes, tests, and experiments. 63.44 Section 63.44... experiments. (a) Definitions for the purposes of this section: (1) Change means a modification or addition to... isolation, are operated or controlled. (6) Tests or experiments not described in the SAR (as updated) means...

10 CFR 63.44 - Changes, tests, and experiments.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Changes, tests, and experiments. 63.44 Section 63.44... experiments. (a) Definitions for the purposes of this section: (1) Change means a modification or addition to... isolation, are operated or controlled. (6) Tests or experiments not described in the SAR (as updated) means...

Structure-activity relationships for skin sensitization: recent improvements to Derek for Windows.

PubMed

Langton, Kate; Patlewicz, Grace Y; Long, Anthony; Marchant, Carol A; Basketter, David A

2006-12-01

Derek for Windows (DfW) is a knowledge-based expert system that predicts the toxicity of a chemical from its structure. Its predictions are based in part on alerts that describe structural features or toxicophores associated with toxicity. Recently, improvements have been made to skin sensitization alerts within the DfW knowledge base in collaboration with Unilever. These include modifications to the alerts describing the skin sensitization potential of aldehydes, 1,2-diketones, and isothiazolinones and consist of enhancements to the toxicophore definition, the mechanistic classification, and the extent of supporting evidence provided. The outcomes from this collaboration demonstrate the importance of updating and refining computer models for the prediction of skin sensitization as new information from experimental and theoretical studies becomes available.

Marfan Syndrome: A Clinical Update.

PubMed

Bitterman, Adam D; Sponseller, Paul D

2017-09-01

Marfan syndrome is a connective tissue disorder that can affect many organ systems. Affected patients present with orthopaedic manifestations of the syndrome during all phases of life. Pain caused by musculoskeletal abnormalities often requires definitive orthopaedic treatment. Orthopaedic surgeons must understand the phenotypes of Marfan syndrome so they can recognize when screening is warranted and can appropriately address the skeletal manifestations. Through medical advancements, patients with Marfan syndrome are living longer and more active lives. Knowledge of the latest diagnostic criteria for the disorder, as well as of advances in understanding the skeletal phenotype, clinical trials of medication therapy, and lifestyle considerations is important for orthopaedic surgeons who treat these patients because these clinicians often are the first to suspect Marfan syndrome and recommend screening.

Universal Darwinism As a Process of Bayesian Inference.

PubMed

Campbell, John O

2016-01-01

Many of the mathematical frameworks describing natural selection are equivalent to Bayes' Theorem, also known as Bayesian updating. By definition, a process of Bayesian Inference is one which involves a Bayesian update, so we may conclude that these frameworks describe natural selection as a process of Bayesian inference. Thus, natural selection serves as a counter example to a widely-held interpretation that restricts Bayesian Inference to human mental processes (including the endeavors of statisticians). As Bayesian inference can always be cast in terms of (variational) free energy minimization, natural selection can be viewed as comprising two components: a generative model of an "experiment" in the external world environment, and the results of that "experiment" or the "surprise" entailed by predicted and actual outcomes of the "experiment." Minimization of free energy implies that the implicit measure of "surprise" experienced serves to update the generative model in a Bayesian manner. This description closely accords with the mechanisms of generalized Darwinian process proposed both by Dawkins, in terms of replicators and vehicles, and Campbell, in terms of inferential systems. Bayesian inference is an algorithm for the accumulation of evidence-based knowledge. This algorithm is now seen to operate over a wide range of evolutionary processes, including natural selection, the evolution of mental models and cultural evolutionary processes, notably including science itself. The variational principle of free energy minimization may thus serve as a unifying mathematical framework for universal Darwinism, the study of evolutionary processes operating throughout nature.

Universal Darwinism As a Process of Bayesian Inference

PubMed Central

Campbell, John O.

2016-01-01

Many of the mathematical frameworks describing natural selection are equivalent to Bayes' Theorem, also known as Bayesian updating. By definition, a process of Bayesian Inference is one which involves a Bayesian update, so we may conclude that these frameworks describe natural selection as a process of Bayesian inference. Thus, natural selection serves as a counter example to a widely-held interpretation that restricts Bayesian Inference to human mental processes (including the endeavors of statisticians). As Bayesian inference can always be cast in terms of (variational) free energy minimization, natural selection can be viewed as comprising two components: a generative model of an “experiment” in the external world environment, and the results of that “experiment” or the “surprise” entailed by predicted and actual outcomes of the “experiment.” Minimization of free energy implies that the implicit measure of “surprise” experienced serves to update the generative model in a Bayesian manner. This description closely accords with the mechanisms of generalized Darwinian process proposed both by Dawkins, in terms of replicators and vehicles, and Campbell, in terms of inferential systems. Bayesian inference is an algorithm for the accumulation of evidence-based knowledge. This algorithm is now seen to operate over a wide range of evolutionary processes, including natural selection, the evolution of mental models and cultural evolutionary processes, notably including science itself. The variational principle of free energy minimization may thus serve as a unifying mathematical framework for universal Darwinism, the study of evolutionary processes operating throughout nature. PMID:27375438

New breeding objectives and selection indices for the Australian dairy industry.

PubMed

Byrne, T J; Santos, B F S; Amer, P R; Martin-Collado, D; Pryce, J E; Axford, M

2016-10-01

This study comprises an update of the economic values for dairy traits for the Australian industry and the formulation of updated selection indices. An economic model, which calculates partial economic values for each trait individually, was developed to determine the economic implications of selective dairy breeding, based on the effect of trait changes on the profit of commercial dairy farms in Australia. Selection indices were developed from economic values, which were transformed into base economic weights by including the discounted genetic expressions coefficients. Economic weights (in Australian dollars) were 1.79, 6.92, -0.10, -5.44, 8.84, 7.68, 1.07, 4.86, 1.91, 3.51, 4.90, 0.31, 2.03, 2.00, and 0.59, for milk fat (kg), milk protein (kg), milk volume (L), body weight (kg), survival (%), residual survival (%), somatic cell count (cells/mL), fertility (%), mammary system [Australian Breeding Value (ABV) unit], temperament (ABV unit), milking speed (ABV unit), udder depth (%), overall type (%), fore udder attachment (%), and pin set (%), respectively. The updated economic weights presented in this study constituted the basis of the definition for 3 new indices. These indices were developed from combination of bioeconomic principles, patterns of farmer preferences for trait improvements, and desired gains approaches. The 3 indices, Balanced Performance Index, Health Weighted Index, and Type Weighted Index, have been released to the industry. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Sublingual immunotherapy: World Allergy Organization position paper 2013 update.

PubMed

Canonica, Giorgio Walter; Cox, Linda; Pawankar, Ruby; Baena-Cagnani, Carlos E; Blaiss, Michael; Bonini, Sergio; Bousquet, Jean; Calderón, Moises; Compalati, Enrico; Durham, Stephen R; van Wijk, Roy Gerth; Larenas-Linnemann, Désirée; Nelson, Harold; Passalacqua, Giovanni; Pfaar, Oliver; Rosário, Nelson; Ryan, Dermot; Rosenwasser, Lanny; Schmid-Grendelmeier, Peter; Senna, Gianenrico; Valovirta, Erkka; Van Bever, Hugo; Vichyanond, Pakit; Wahn, Ulrich; Yusuf, Osman

2014-03-28

We have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of the originally published paper, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2009", available at http://www.waojournal.org. Namely, these comprise: "Mechanisms of sublingual immunotherapy;" "Clinical efficacy of sublingual immunotherapy" - reporting all the data of all controlled trials published after 2009; "Safety of sublingual immunotherapy" - with the recently published Grading System for adverse reactions; "Impact of sublingual immunotherapy on the natural history of respiratory allergy" - with the relevant evidences published since 2009; "Efficacy of SLIT in children" - with detailed analysis of all the studies; "Definition of SLIT patient selection" - reporting the criteria for eligibility to sublingual immunotherapy; "The future of immunotherapy in the community care setting"; "Methodology of clinical trials according to the current scientific and regulatory standards"; and "Guideline development: from evidence-based medicine to patients' views" - including the evolution of the methods to make clinical recommendations.Additionally, we have added new chapters to cover a few emerging crucial topics: "Practical aspects of schedules and dosages and counseling for adherence" - which is crucial in clinical practice for all treatments; "Perspectives and new approaches" - including recombinant allergens, adjuvants, modified allergens, and the concept of validity of the single products. Furthermore, "Raising public awareness about sublingual immunotherapy", as a need for our patients, and strategies to increase awareness of allergen immunotherapy (AIT) among patients, the medical community, all healthcare stakeholders, and public opinion, are also reported in detail.

Project W-211 initial tank retrieval systems year 2000 compliance assessment project plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

BUSSELL, J.H.

1999-08-24

This assessment describes the potential Year 2000 (Y2K) problems and describes the methods for achieving Y2K Compliance for Project W-211, Initial Tank Retrieval Systems (ITRS). The purpose of this assessment is to give an overview of the project. This document will not be updated and any dates contained in this document are estimates and may change. The scope of project W-211 is to provide systems for retrieval of radioactive wastes from ten double-shell tanks (DST). systems will be installed in tanks 102-AP, 104-AP, 105-AN, 104-AN, 102-AZ, 101-AW, 103-AN, 107-AN, 102-AY, and 102-SY. The current tank selection and sequence supports phasemore » I feed delivery to privatized processing plants. A detailed description of system dates, functions, interfaces, potential Y2K problems, and date resolutions can not be described since the project is in the definitive design phase. This assessment will describe the methods, protocols, and practices to assure that equipment and systems do not have Y2K problems.« less

Systemic lupus erythematosus: an update.

PubMed

Golder, Vera; Hoi, Alberta

2017-03-20

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease predominantly affecting women of childbearing age. New classification criteria for SLE have greater sensitivity and therefore improve the diagnostic certainty for some patients, especially those who may previously have been labelled as having undifferentiated symptoms. Uncontrolled disease activity leads to irreversible end-organ damage, which in turn increases the risk of premature death; early and sustained control of disease activity can usually be achieved by conventional immunosuppressant therapy. The development of biological therapy lags behind that for other rheumatic diseases, with belimumab being the only targeted therapy approved by the Therapeutic Goods Administration. "Treat-to-target" concepts are changing trial design and clinical practice, with evidence-based definition of response criteria in the form of remission and low disease activity now on the horizon. While new therapies are awaited, research should also focus on optimising the use of current therapy and improving the quality of care of patients with SLE.

Targeting of herbal bioactives through folate receptors: a novel concept to enhance intracellular drug delivery in cancer therapy.

PubMed

Gupta, Anshita; Kaur, Chanchal Deep; Saraf, Shailendra; Saraf, Swarnlata

2017-06-01

Targeted drug delivery through folate receptor (FR) has emerged as a most biocompatible, target oriented, and non-immunogenic cargoes for the delivery of anticancer drugs. FRs are highly overexpressed in many tumor cells (like ovarian, lung, breast, kidney, brain, endometrial, and colon cancer), and targeting them through conjugates bearing specific ligand with encapsulated nanodrug moiety is undoubtedly, a promising approach toward tumor targeting. Folate, being an endogenous ligand, can be exploited well to affect various cellular events occurring during the progress of tumor, in a more natural and definite way. Thus, the aim of the review lies in summarizing the advancements taken place in the drug delivery system of different therapeutics through FRs and to refine its role as an endogenous ligand, in targeting of synthetic as well as natural bioactives. The review also provides an update on the patents received on the folate-based drug delivery system.

Closed Loop Requirements and Analysis Management

NASA Technical Reports Server (NTRS)

Lamoreaux, Michael; Verhoef, Brett

2015-01-01

Effective systems engineering involves the use of analysis in the derivation of requirements and verification of designs against those requirements. The initial development of requirements often depends on analysis for the technical definition of specific aspects of a product. Following the allocation of system-level requirements to a product's components, the closure of those requirements often involves analytical approaches to verify that the requirement criteria have been satisfied. Meanwhile, changes that occur in between these two processes need to be managed in order to achieve a closed-loop requirement derivation/verification process. Herein are presented concepts for employing emerging Team center capabilities to jointly manage requirements and analysis data such that analytical techniques are utilized to effectively derive and allocate requirements, analyses are consulted and updated during the change evaluation processes, and analyses are leveraged during the design verification process. Recommendations on concept validation case studies are also discussed.

Model-Free Adaptive Control for Unknown Nonlinear Zero-Sum Differential Game.

PubMed

Zhong, Xiangnan; He, Haibo; Wang, Ding; Ni, Zhen

2018-05-01

In this paper, we present a new model-free globalized dual heuristic dynamic programming (GDHP) approach for the discrete-time nonlinear zero-sum game problems. First, the online learning algorithm is proposed based on the GDHP method to solve the Hamilton-Jacobi-Isaacs equation associated with optimal regulation control problem. By setting backward one step of the definition of performance index, the requirement of system dynamics, or an identifier is relaxed in the proposed method. Then, three neural networks are established to approximate the optimal saddle point feedback control law, the disturbance law, and the performance index, respectively. The explicit updating rules for these three neural networks are provided based on the data generated during the online learning along the system trajectories. The stability analysis in terms of the neural network approximation errors is discussed based on the Lyapunov approach. Finally, two simulation examples are provided to show the effectiveness of the proposed method.

Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity--an update.

PubMed

Grunberg, Steven M; Osoba, David; Hesketh, Paul J; Gralla, Richard J; Borjeson, Sussanne; Rapoport, Bernardo L; du Bois, Andreas; Tonato, Maurizio

2005-02-01

Development of effective antiemetic therapy depends upon an understanding of both the antiemetic agents and the emetogenic challenges these agents are designed to address. New potential antiemetic agents should be studied in an orderly manner, proceeding from phase I to phase II open-label trials and then to randomized double-blind phase III trials comparing new agents and regimens to best standard therapy. Use of placebos in place of antiemetic therapy against highly or moderately emetogenic chemotherapy is unacceptable. Nausea and vomiting should be evaluated separately and for both the acute and delayed periods. Defining the emetogenicity of new antineoplastic agents is a challenge, since such data are often not reliably recorded during early drug development. A four-level classification system is proposed for emetogenicity of intravenous antineoplastic agents. A separate four-level classification system for emetogenicity of oral antineoplastic agents, which are often given over an extended period of time, is also proposed.

Space Station Mission Planning Study (MPS) development study. Volume 3: Software development plan

NASA Technical Reports Server (NTRS)

Klus, W. L.

1987-01-01

A software development plan is presented for the definition, design, and implementation of the Space Station (SS) Payload Mission Planning System (MPS). This plan is an evolving document and must be updated periodically as the SS design and operations concepts as well as the SS MPS concept evolve. The major segments of this plan are as follows: an overview of the SS MPS and a description of its required capabilities including the computer programs identified as configurable items with an explanation of the place and function of each within the system; an overview of the project plan and a detailed description of each development project activity breaking each into lower level tasks where applicable; identification of the resources required and recommendations for the manner in which they should be utilized including recommended schedules and estimated manpower requirements; and a description of the practices, standards, and techniques recommended for the SS MPS Software (SW) development.

The SISMA Project: A pre-operative seismic hazard monitoring system.

NASA Astrophysics Data System (ADS)

Massimiliano Chersich, M. C.; Amodio, A. A. Angelo; Francia, A. F. Andrea; Sparpaglione, C. S. Claudio

2009-04-01

Galileian Plus is currently leading the development, in collaboration with several Italian Universities, of the SISMA (Seismic Information System for Monitoring and Alert) Pilot Project financed by the Italian Space Agency. The system is devoted to the continuous monitoring of the seismic risk and is addressed to support the Italian Civil Protection decisional process. Completion of the Pilot Project is planned at the beginning of 2010. Main scientific paradigm of SISMA is an innovative deterministic approach integrating geophysical models, geodesy and active tectonics. This paper will give a general overview of project along with its progress status and a particular focus will be put on the architectural design details and to the software implementation choices. SISMA is built on top of a software infrastructure developed by Galileian Plus to integrate the scientific programs devoted to the update of seismic risk maps. The main characteristics of the system may be resumed as follow: automatic download of input data; integration of scientific programs; definition and scheduling of chains of processes; monitoring and control of the system through a graphical user interface (GUI); compatibility of the products with ESRI ArcGIS, by mean of post-processing conversion. a) automatic download of input data SISMA needs input data such as GNSS observations, updated seismic catalogue, SAR satellites orbits, etc. that are periodically updated and made available from remote servers through FTP and HTTP. This task is accomplished by a dedicated user configurable component. b) integration of scientific programs SISMA integrates many scientific programs written in different languages (Fortran, C, C++, Perl and Bash) and running into different operating systems. This design requirements lead to the development of a distributed system which is platform independent and is able to run any terminal-based program following few simple predefined rules. c) definition and scheduling of chains of processes Processes are bound each other, in the sense that the output of process "A" should be passed as input to process "B". In this case the process "B" must run automatically as soon as the required input is ready. In SISMA this issue is handled with the "data-driven" activation concept allowing specifying that a process should be started as soon as the needed input datum has been made available in the archive. Moreover SISMA may run processes on a "time-driven" base. The infrastructure of SISMA provides a configurable scheduler allowing the user to define the start time and the periodicity of such processes. d) monitoring and control The operator of the system needs to monitor and control every process running in the system. The SISMA infrastructure allows, through its GUI, the user to: view log messages of running and old processes; stop running processes; monitor processes executions; monitor resource status (available ram, network reachability, and available disk space) for every machine in the system. e) compatibility with ESRI Shapefiles Nearly all the SISMA data has some geographic information, and it is useful to integrate it in a Geographic Information System (GIS). Processors output are georeferred, but they are generated as ASCII files in a proprietary format, and thus cannot directly loaded in a GIS. The infrastructures provides a simple framework for adding filters that reads the data in the proprietary format and converts it to ESRI Shapefile format.

78 FR 79458 - Privacy Act of 1974; Notice of an Updated System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

... systems to ensure that they are relevant, necessary, accurate, up-to-date, and covered by the appropriate legal or regulatory authority. This notice is an updated Privacy Act system of records notice. DATES...] Privacy Act of 1974; Notice of an Updated System of Records AGENCY: General Services Administration...

Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning.

PubMed

Ekino, Shigeo; Susa, Mari; Ninomiya, Tadashi; Imamura, Keiko; Kitamura, Toshinori

2007-11-15

The first well-documented outbreak of acute methyl mercury (MeHg) poisoning by consumption of contaminated fish occurred in Minamata, Japan, in 1953. The clinical picture was officially recognized and called Minamata disease (MD) in 1956. However, 50 years later there are still arguments about the definition of MD in terms of clinical symptoms and extent of lesions. We provide a historical review of this epidemic and an update of the problem of MeHg toxicity. Since MeHg dispersed from Minamata to the Shiranui Sea, residents living around the sea were exposed to low-dose MeHg through fish consumption for about 20 years (at least from 1950 to 1968). These patients with chronic MeHg poisoning continue to complain of distal paresthesias of the extremities and the lips even 30 years after cessation of exposure to MeHg. Based on findings in these patients the symptoms and lesions in MeHg poisoning are reappraised. The persisting somatosensory disorders after discontinuation of exposure to MeHg were induced by diffuse damage to the somatosensory cortex, but not by damage to the peripheral nervous system, as previously believed.

Medical and dermatology dictionaries: an examination of unstructured definitions and a proposal for the future.

PubMed

DeVries, David Todd; Papier, Art; Byrnes, Jennifer; Goldsmith, Lowell A

2004-01-01

Medical dictionaries serve to describe and clarify the term set used by medical professionals. In this commentary, we analyze a representative set of skin disease definitions from 2 prominent medical dictionaries, Stedman's Medical Dictionary and Dorland's Illustrated Medical Dictionary. We find that there is an apparent lack of stylistic standards with regard to content and form. We advocate a new standard form for the definition of medical terminology, a standard to complement the easy-to-read yet unstructured style of the traditional dictionary entry. This new form offers a reproducible structure, paving the way for the development of a computer readable "dictionary" of medical terminology. Such a dictionary offers immediate update capability and a fundamental improvement in the ability to search for relationships between terms.

Examining metabolic syndrome definitions in overweight Hispanic youth: a focus on insulin resistance.

PubMed

Shaibi, Gabriel Q; Goran, Michael I

2008-02-01

To examine the prevalence of the metabolic syndrome in overweight Hispanic youth according to 3 published pediatric definitions. Furthermore, the relationship of each definition to directly measured insulin resistance was examined. We conducted a secondary data analysis of 218 overweight Hispanic youth with a family history of type 2 diabetes mellitus. The metabolic syndrome was defined as >/=3 of these criteria: elevated triglyceride level, low high-density lipoprotein cholesterol level, elevated blood pressure, abdominal obesity, and hyperglycemia. The cutoff points were derived from updated definitions of Cook et al,(1) Cruz et al,(2) and Weiss et al.(3) Insulin sensitivity was determined with the insulin-modified frequently sampled intravenous glucose tolerance test. Prevalence of the metabolic syndrome ranged from 25.7% to 39%, with moderate to substantial agreement between definitions (kappa = 0.52-0.70). Regardless of definition, an inverse relationship between metabolic risk and insulin sensitivity was noted such that children with the metabolic syndrome had 51% to 60% lower insulin sensitivity compared with children without any risk factors (P

76 FR 56762 - Privacy Act of 1974; Notice of Updated Systems of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-14

... 1974; Notice of Updated Systems of Records AGENCY: General Services Administration. ACTION: Updated Notice. SUMMARY: The General Services Administration (GSA) reviewed its Privacy Act systems to ensure that they are relevant, necessary, accurate, up- to-date, covered by the appropriate legal or...

An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)

PubMed Central

Althof, Stanley E; McMahon, Chris G; Waldinger, Marcel D; Serefoglu, Ege Can; Shindel, Alan W; Adaikan, P Ganesan; Becher, Edgardo; Dean, John; Giuliano, Francois; Hellstrom, Wayne JG; Giraldi, Annamaria; Glina, Sidney; Incrocci, Luca; Jannini, Emmanuele; McCabe, Marita; Parish, Sharon; Rowland, David; Segraves, R Taylor; Sharlip, Ira; Torres, Luiz Otavio

2014-01-01

Introduction In 2009, the International Society for Sexual Medicine (ISSM) convened a select panel of experts to develop an evidence-based set of guidelines for patients suffering from lifelong premature ejaculation (PE). That document reviewed definitions, etiology, impact on the patient and partner, assessment, and pharmacological, psychological, and combined treatments. It concluded by recognizing the continually evolving nature of clinical research and recommended a subsequent guideline review and revision every fourth year. Consistent with that recommendation, the ISSM organized a second multidisciplinary panel of experts in April 2013, which met for 2 days in Bangalore, India. This manuscript updates the previous guidelines and reports on the recommendations of the panel of experts. Aim The aim of this study was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of PE for family practice clinicians as well as sexual medicine experts. Method A comprehensive literature review was performed. Results This article contains the report of the second ISSM PE Guidelines Committee. It offers a new unified definition of PE and updates the previous treatment recommendations. Brief assessment procedures are delineated, and validated diagnostic and treatment questionnaires are reviewed. Finally, the best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients. Conclusion Development of guidelines is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction. We again recommend that these guidelines be reevaluated and updated by the ISSM in 4 years. Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, Becher E, Dean J, Giuliano F, Hellstrom WJG, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, and Torres LO. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60–90. PMID:25356302

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayes, T.; Smith, K.S.; Severino, F.

A critical capability of the new RHIC low level rf (LLRF) system is the ability to synchronize signals across multiple locations. The 'Update Link' provides this functionality. The 'Update Link' is a deterministic serial data link based on the Xilinx RocketIO protocol that is broadcast over fiber optic cable at 1 gigabit per second (Gbps). The link provides timing events and data packets as well as time stamp information for synchronizing diagnostic data from multiple sources. The new RHIC LLRF was designed to be a flexible, modular system. The system is constructed of numerous independent RF Controller chassis. To providemore » synchronization among all of these chassis, the Update Link system was designed. The Update Link system provides a low latency, deterministic data path to broadcast information to all receivers in the system. The Update Link system is based on a central hub, the Update Link Master (ULM), which generates the data stream that is distributed via fiber optic links. Downstream chassis have non-deterministic connections back to the ULM that allow any chassis to provide data that is broadcast globally.« less

Oral Language Proficiency Testing at the Foreign Service Institute. An Update--1983.

ERIC Educational Resources Information Center

Crawford, Gary D.; And Others

The Foreign Service Institute (FSI) has been engaged in oral language proficiency testing theory and practice for more than 20 years. The FSI test has been consistent during this time in format, evaluation criteria, performance standards, and level definitions. Current concerns about the degree of standardization of the format and the strength of…

Adult Literacy Issues, Programs, and Options. CRS Issue Brief. Updated.

ERIC Educational Resources Information Center

Irwin, Paul M.

Media reports suggest widespread illiteracy among adults who may not be able to read, write, speak, or otherwise communicate competently enough to meet the demands of modern society. No consensus has been reached regarding a definition of illiteracy or supporting statistics. Estimates of adult illiteracy range form 0.5% to 50%, meaning that of the…

Child Care Center Licensing Study, 2001.

ERIC Educational Resources Information Center

Children's Foundation, Washington, DC.

This report is an update of information initially compiled in 1991 through a survey of the child care regulatory offices of the 50 U.S. states, the District of Columbia, Puerto Rico, and the Virgin Islands. The report begins with an introduction, definition of terms, and a question and answer summary. The bulk of the report is organized in…

Child Care Center Licensing Study, 2003.

ERIC Educational Resources Information Center

Children's Foundation, Washington, DC.

This report is a yearly update of information initially compiled in 1991 through a survey of the child care regulatory offices of the 50 U.S. states, the District of Columbia, Puerto Rico, and the Virgin Islands. The report begins with an introduction, definition of terms, and a question and answer summary. The bulk of the report is organized in…

Child Care Center Licensing Study, 2002.

ERIC Educational Resources Information Center

Children's Foundation, Washington, DC.

This report is an update of information initially compiled in 1991 through a survey of the child care regulatory offices of the 50 U.S. states, the District of Columbia, Puerto Rico, and the Virgin Islands. The report begins with an introduction, definition of terms, and a question and answer summary. The bulk of the report is organized in…

Awakening the Sleeping Giant: Helping Teachers Develop as Leaders. Second Edition.

ERIC Educational Resources Information Center

Katzenmayer, Marilyn; Moller, Gayle

This book presents updated research on and examples of teacher leadership, offering practical tips for educators at all levels, tools for self-assessment, and a new vision of the future. The eight chapters are: (1) "What Is Teacher Leadership?" (e.g., definition of teacher leadership, roles for teacher leaders, and who is responsible); (2)…

Update: What Nurses Need to Know about Human Trafficking.

PubMed

Washburn, Joy

Nurses are key people who interact with victims of human trafficking in healthcare and other settings. This article provides a current overview of human trafficking, explains legal definitions, elements for protocols in healthcare settings when trafficking is suspected, nursing roles and responses, interview tools, resources, public health recommendations, and nursing education approaches to address human trafficking.

42 CFR 483.315 - Specification of resident assessment instrument.

Code of Federal Regulations, 2010 CFR

2010-10-01

... updated periodically, and consists of the following: (1) The minimum data set (MDS) and common definitions... specified by CMS. (4) The requirements for use of the RAI that appear at § 483.20. (e) Minimum data set (MDS...) Specify to a facility the method of transmission of data, and instruct the facility on this method. (3...

42 CFR 483.315 - Specification of resident assessment instrument.

Code of Federal Regulations, 2014 CFR

2014-10-01

... updated periodically, and consists of the following: (1) The minimum data set (MDS) and common definitions... specified by CMS. (4) The requirements for use of the RAI that appear at § 483.20. (e) Minimum data set (MDS...) Specify to a facility the method of transmission of data, and instruct the facility on this method. (3...

42 CFR 483.315 - Specification of resident assessment instrument.

Code of Federal Regulations, 2012 CFR

2012-10-01

... updated periodically, and consists of the following: (1) The minimum data set (MDS) and common definitions... specified by CMS. (4) The requirements for use of the RAI that appear at § 483.20. (e) Minimum data set (MDS...) Specify to a facility the method of transmission of data, and instruct the facility on this method. (3...

42 CFR 483.315 - Specification of resident assessment instrument.

Code of Federal Regulations, 2013 CFR

2013-10-01

... updated periodically, and consists of the following: (1) The minimum data set (MDS) and common definitions... specified by CMS. (4) The requirements for use of the RAI that appear at § 483.20. (e) Minimum data set (MDS...) Specify to a facility the method of transmission of data, and instruct the facility on this method. (3...

42 CFR 483.315 - Specification of resident assessment instrument.

Code of Federal Regulations, 2011 CFR

2011-10-01

... updated periodically, and consists of the following: (1) The minimum data set (MDS) and common definitions... specified by CMS. (4) The requirements for use of the RAI that appear at § 483.20. (e) Minimum data set (MDS...) Specify to a facility the method of transmission of data, and instruct the facility on this method. (3...

Bullying and Cyberbullying at Colleges and Universities. Prevention Update

ERIC Educational Resources Information Center

Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2012

2012-01-01

According to StopBullying.gov, an official U.S. government Web site managed by the Department of Health and Human Services in partnership with the Department of Education and Department of Justice, definitions of bullying vary, but "most agree that bullying involves: (1) Imbalance of Power: people who bully use their power to control or harm and…

Child Care Center Licensing Study, 2000.

ERIC Educational Resources Information Center

Children's Foundation, Washington, DC.

This report is an update of information initially compiled in 1991 through a survey of the child care regulatory offices of the 50 United States, the District of Columbia, Puerto Rico, and the Virgin Islands. The report begins with an introduction, definition of terms, and a question and answer summary. The bulk of the report is organized in…

78 FR 76067 - Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-16

... with the Air Transport Association Common Support Data Dictionary; and (ii) The encoded data elements... 211.274-2(a)(2) and (3) are revised to consolidate requirements. The definition of ``data matrix... Registry'' is added at 252.211-7003(c)(2). The phrase ``ECC200 data matrix specification'' is added at 252...

34 CFR 230.2 - What definitions apply to the Troops-to-Teacher program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... incomes below the poverty line means the updated data on the number of children ages 5 through 17 from families with incomes below the poverty line provided by the Department of Commerce that the Secretary uses... agency— (1) That serves not fewer than 10,000 children from families with incomes below the poverty line...

Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review

PubMed Central

Brurberg, Kjetil Gundro; Fønhus, Marita Sporstøl; Larun, Lillebeth; Flottorp, Signe; Malterud, Kirsti

2014-01-01

Objective To identify case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), and explore how the validity of case definitions can be evaluated in the absence of a reference standard. Design Systematic review. Setting International. Participants A literature search, updated as of November 2013, led to the identification of 20 case definitions and inclusion of 38 validation studies. Primary and secondary outcome measure Validation studies were assessed for risk of bias and categorised according to three validation models: (1) independent application of several case definitions on the same population, (2) sequential application of different case definitions on patients diagnosed with CFS/ME with one set of diagnostic criteria or (3) comparison of prevalence estimates from different case definitions applied on different populations. Results A total of 38 studies contributed data of sufficient quality and consistency for evaluation of validity, with CDC-1994/Fukuda as the most frequently applied case definition. No study rigorously assessed the reproducibility or feasibility of case definitions. Validation studies were small with methodological weaknesses and inconsistent results. No empirical data indicated that any case definition specifically identified patients with a neuroimmunological condition. Conclusions Classification of patients according to severity and symptom patterns, aiming to predict prognosis or effectiveness of therapy, seems useful. Development of further case definitions of CFS/ME should be given a low priority. Consistency in research can be achieved by applying diagnostic criteria that have been subjected to systematic evaluation. PMID:24508851

What Is Lean Management in Health Care? Development of an Operational Definition for a Cochrane Systematic Review.

PubMed

Rotter, Thomas; Plishka, Christopher; Lawal, Adegboyega; Harrison, Liz; Sari, Nazmi; Goodridge, Donna; Flynn, Rachel; Chan, James; Fiander, Michelle; Poksinska, Bonnie; Willoughby, Keith; Kinsman, Leigh

2018-01-01

Industrial improvement approaches such as Lean management are increasingly being adopted in health care. Synthesis is necessary to ensure these approaches are evidence based and requires operationalization of concepts to ensure all relevant studies are included. This article outlines the process utilized to develop an operational definition of Lean in health care. The literature search, screening, data extraction, and data synthesis processes followed the recommendations outlined by the Cochrane Collaboration. Development of the operational definition utilized the methods prescribed by Kinsman et al. and Wieland et al. This involved extracting characteristics of Lean, synthesizing similar components to establish an operational definition, applying this definition, and updating the definition to address shortcomings. We identified two defining characteristics of Lean health-care management: (1) Lean philosophy, consisting of Lean principles and continuous improvement, and (2) Lean activities, which include Lean assessment activities and Lean improvement activities. The resulting operational definition requires that an organization or subunit of an organization had integrated Lean philosophy into the organization's mandate, guidelines, or policies and utilized at least one Lean assessment activity or Lean improvement activity. This operational definition of Lean management in health care will act as an objective screening criterion for our systematic review. To our knowledge, this is the first evidence-based operational definition of Lean management in health care.

Knowledge structure representation and automated updates in intelligent information management systems

NASA Technical Reports Server (NTRS)

Corey, Stephen; Carnahan, Richard S., Jr.

1990-01-01

A continuing effort to apply rapid prototyping and Artificial Intelligence techniques to problems associated with projected Space Station-era information management systems is examined. In particular, timely updating of the various databases and knowledge structures within the proposed intelligent information management system (IIMS) is critical to support decision making processes. Because of the significantly large amounts of data entering the IIMS on a daily basis, information updates will need to be automatically performed with some systems requiring that data be incorporated and made available to users within a few hours. Meeting these demands depends first, on the design and implementation of information structures that are easily modified and expanded, and second, on the incorporation of intelligent automated update techniques that will allow meaningful information relationships to be established. Potential techniques are studied for developing such an automated update capability and IIMS update requirements are examined in light of results obtained from the IIMS prototyping effort.

MedlinePlus FAQ: How Often MedlinePlus is Updated

MedlinePlus

... System Pharmacists is updated monthly. Natural Medicines Comprehensive Database Consumer Version is updated quarterly. Medical Encyclopedia: Updated monthly. ... Guidelines Viewers & Players MedlinePlus Connect for ...

Abu Dhabi Basemap Update Using the LiDAR Mobile Mapping Technology

NASA Astrophysics Data System (ADS)

Alshaiba, Omar; Amparo Núñez-Andrés, M.; Lantada, Nieves

2016-04-01

Mobile LiDAR system provides a new technology which can be used to update geospatial information by direct and rapid data collection. This technology is faster than the traditional survey ways and has lower cost. Abu Dhabi Municipal System aims to update its geospatial system frequently as the government entities have invested heavily in GIS technology and geospatial data to meet the repaid growth in the infrastructure and construction projects in recent years. The Emirate of Abu Dhabi has witnessed a huge growth in infrastructure and construction projects in recent years. Therefore, it is necessary to develop and update its basemap system frequently to meet their own organizational needs. Currently, the traditional ways are used to update basemap system such as human surveyors, GPS receivers and controller (GPS assigned computer). Then the surveyed data are downloaded, edited and reviewed manually before it is merged to the basemap system. Traditional surveying ways may not be applicable in some conditions such as; bad weather, difficult topographic area and boundary area. This paper presents a proposed methodology which uses the Mobile LiDAR system to update basemap in Abu Dhabi by using daily transactions services. It aims to use and integrate the mobile LiDAR technology into the municipality's daily workflow such that it becomes the new standard cost efficiency operating procedure for updating the base-map in Abu Dhabi Municipal System. On another note, the paper will demonstrate the results of the innovated workflow for the base-map update using the mobile LiDAR point cloud and few processing algorithms.

75 FR 81138 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

... [CMS-1510-CN2] RIN 0938-AP88 Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011; Changes in Certification Requirements for Home Health Agencies and Hospices AGENCY... ``Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011; Changes in...

Adaptation of clinical prediction models for application in local settings.

PubMed

Kappen, Teus H; Vergouwe, Yvonne; van Klei, Wilton A; van Wolfswinkel, Leo; Kalkman, Cor J; Moons, Karel G M

2012-01-01

When planning to use a validated prediction model in new patients, adequate performance is not guaranteed. For example, changes in clinical practice over time or a different case mix than the original validation population may result in inaccurate risk predictions. To demonstrate how clinical information can direct updating a prediction model and development of a strategy for handling missing predictor values in clinical practice. A previously derived and validated prediction model for postoperative nausea and vomiting was updated using a data set of 1847 patients. The update consisted of 1) changing the definition of an existing predictor, 2) reestimating the regression coefficient of a predictor, and 3) adding a new predictor to the model. The updated model was then validated in a new series of 3822 patients. Furthermore, several imputation models were considered to handle real-time missing values, so that possible missing predictor values could be anticipated during actual model use. Differences in clinical practice between our local population and the original derivation population guided the update strategy of the prediction model. The predictive accuracy of the updated model was better (c statistic, 0.68; calibration slope, 1.0) than the original model (c statistic, 0.62; calibration slope, 0.57). Inclusion of logistical variables in the imputation models, besides observed patient characteristics, contributed to a strategy to deal with missing predictor values at the time of risk calculation. Extensive knowledge of local, clinical processes provides crucial information to guide the process of adapting a prediction model to new clinical practices.

Update on the Epidemiology of Concussion/Mild Traumatic Brain Injury.

PubMed

Voss, Jameson D; Connolly, Joseph; Schwab, Karen A; Scher, Ann I

2015-07-01

Mild traumatic injuries to the brain (e.g., concussion) are common and have been recognized since antiquity, although definitions have varied historically. Nonetheless, studying the epidemiology of concussion helps clarify the overall importance, risk factors, and at-risk populations for this injury. The present review will focus on recent findings related to the epidemiology of concussion including definition controversies, incidence, and patterns in the population overall and in the military and athlete populations specifically. Finally, as this is an area of active research, we will discuss how future epidemiologic observations hold promise for gaining greater clarity about concussion and mild traumatic brain injury.

Syndromology: an updated conceptual overview. I. Syndrome concepts, designations, and population characteristics.

PubMed

Cohen, M M

1989-08-01

Part I introduces the survey and presents a topic outline of the 10 parts that make up this overview of syndromology in this and the next four issues. The discussion in Part I considers various concepts and definitions of the term "syndrome" and different ways of applying syndrome designations. A population definition of a syndrome is then developed to show the meaning of common, less common, and occasional anomalies in various syndromes. The differences between a true multiple anomaly syndrome and a variant familial pattern are discussed. Finally, two types of weak recurrent patterns--chance patterns and association patterns--are explained.

Survey Definitions of Gout for Epidemiologic Studies: Comparison With Crystal Identification as the Gold Standard.

PubMed

Dalbeth, Nicola; Schumacher, H Ralph; Fransen, Jaap; Neogi, Tuhina; Jansen, Tim L; Brown, Melanie; Louthrenoo, Worawit; Vazquez-Mellado, Janitzia; Eliseev, Maxim; McCarthy, Geraldine; Stamp, Lisa K; Perez-Ruiz, Fernando; Sivera, Francisca; Ea, Hang-Korng; Gerritsen, Martijn; Scire, Carlo A; Cavagna, Lorenzo; Lin, Chingtsai; Chou, Yin-Yi; Tausche, Anne-Kathrin; da Rocha Castelar-Pinheiro, Geraldo; Janssen, Matthijs; Chen, Jiunn-Horng; Cimmino, Marco A; Uhlig, Till; Taylor, William J

2016-12-01

To identify the best-performing survey definition of gout from items commonly available in epidemiologic studies. Survey definitions of gout were identified from 34 epidemiologic studies contributing to the Global Urate Genetics Consortium (GUGC) genome-wide association study. Data from the Study for Updated Gout Classification Criteria (SUGAR) were randomly divided into development and test data sets. A data-driven case definition was formed using logistic regression in the development data set. This definition, along with definitions used in GUGC studies and the 2015 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) gout classification criteria were applied to the test data set, using monosodium urate crystal identification as the gold standard. For all tested GUGC definitions, the simple definition of "self-report of gout or urate-lowering therapy use" had the best test performance characteristics (sensitivity 82%, specificity 72%). The simple definition had similar performance to a SUGAR data-driven case definition with 5 weighted items: self-report, self-report of doctor diagnosis, colchicine use, urate-lowering therapy use, and hyperuricemia (sensitivity 87%, specificity 70%). Both of these definitions performed better than the 1977 American Rheumatism Association survey criteria (sensitivity 82%, specificity 67%). Of all tested definitions, the 2015 ACR/EULAR criteria had the best performance (sensitivity 92%, specificity 89%). A simple definition of "self-report of gout or urate-lowering therapy use" has the best test performance characteristics of existing definitions that use routinely available data. A more complex combination of features is more sensitive, but still lacks good specificity. If a more accurate case definition is required for a particular study, the 2015 ACR/EULAR gout classification criteria should be considered. © 2016, American College of Rheumatology.

Update of the Case Definitions for Population-Based Surveillance of Periodontitis

PubMed Central

Eke, Paul I.; Page, Roy C.; Wei, Liang; Thornton-Evans, Gina; Genco, Robert J.

2018-01-01

Background This report adds a new definition for mild periodontitis that allows for better descriptions of the overall prevalence of periodontitis in populations. In 2007, the Centers for Disease Control and Prevention in partnership with the American Academy of Periodontology developed and reported standard case definitions for surveillance of moderate and severe periodontitis based on measurements of probing depth (PD) and clinical attachment loss (AL) at interproximal sites. However, combined cases of moderate and severe periodontitis are insufficient to determine the total prevalence of periodontitis in populations. Methods The authors proposed a definition for mild periodontitis as ≥2 interproximal sites with AL ≥3 mm and ≥2 interproximal sites with PD ≥4 mm (not on the same tooth) or one site with PD ≥5 mm. The effect of the proposed definition on the total burden of periodontitis was assessed in a convenience sample of 456 adults ≥35 years old and compared with other previously reported definitions for similar categories of periodontitis. Results Addition of mild periodontitis increases the total prevalence of periodontitis by ≈31% in this sample when compared with the prevalence of severe and moderate disease. Conclusion Total periodontitis using the case definitions in this study should be based on the sum of mild, moderate, and severe periodontitis. PMID:22420873

Is a community still a community? Reviewing definitions of key terms in community ecology.

PubMed

Stroud, James T; Bush, Michael R; Ladd, Mark C; Nowicki, Robert J; Shantz, Andrew A; Sweatman, Jennifer

2015-11-01

Community ecology is an inherently complicated field, confounded by the conflicting use of fundamental terms. Nearly two decades ago, Fauth et al. (1996) demonstrated that imprecise language led to the virtual synonymy of important terms and so attempted to clearly define four keywords in community ecology; "community," "assemblage," "guild," and "ensemble". We revisit Fauth et al.'s conclusion and discuss how the use of these terms has changed over time since their review. An updated analysis of term definition from a selection of popular ecological textbooks suggests that definitions have drifted away from those encountered pre-1996, and slightly disagreed with results from a survey of 100 ecology professionals (comprising of academic professors, nonacademic PhDs, graduate and undergraduate biology students). Results suggest that confusion about these terms is still widespread in ecology. We conclude with clear suggestions for definitions of each term to be adopted hereafter to provide greater cohesion among research groups.

Clinical Trial Principles and Endpoint Definitions for Paravalvular Leaks in Surgical Prosthesis: An Expert Statement.

PubMed

Ruiz, Carlos E; Hahn, Rebecca T; Berrebi, Alain; Borer, Jeffrey S; Cutlip, Donald E; Fontana, Greg; Gerosa, Gino; Ibrahim, Reda; Jelnin, Vladimir; Jilaihawi, Hasan; Jolicoeur, E Marc; Kliger, Chad; Kronzon, Itzhak; Leipsic, Jonathon; Maisano, Francesco; Millan, Xavier; Nataf, Patrick; O'Gara, Patrick T; Pibarot, Philippe; Ramee, Stephen R; Rihal, Charanjit S; Rodes-Cabau, Josep; Sorajja, Paul; Suri, Rakesh; Swain, Julie A; Turi, Zoltan G; Tuzcu, E Murat; Weissman, Neil J; Zamorano, Jose L; Serruys, Patrick W; Leon, Martin B

2017-04-25

The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices. The PVL Academic Research Consortium met to review evidence and make recommendations for assessment of disease severity, data collection, and updated endpoint definitions. A 5-class grading scheme to evaluate PVL was developed in concordance with VARC recommendations. Unresolved issues in the field are outlined. The current PVL Academic Research Consortium provides recommendations for assessment of disease severity, data collection, and endpoint definitions. Future research in the field is warranted. Copyright © 2017 American College of Cardiology Foundation and European Society of Cardiology. Published by Elsevier Inc. All rights reserved.

Sympathoneural and Adrenomedullary Responses to Mental Stress

PubMed Central

Carter, Jason R.; Goldstein, David S.

2017-01-01

This concept-based review provides historical perspectives and updates about sympathetic noradrenergic and sympathetic adrenergic responses to mental stress. The topic of this review has incited perennial debate, because of disagreements over definitions, controversial inferences, and limited availability of relevant measurement tools. The discussion begins appropriately with Cannon's "homeostasis" and his pioneering work in the area. This is followed by mental stress as a scientific idea and the relatively new notions of allostasis and allostatic load. Experimental models of mental stress in rodents and humans are discussed, with particular attention to ethical constraints in humans. Sections follow on sympathoneural to mental stress, reactivity of catecholamine systems, clinical pathophysiologic states, and the cardiovascular reactivity hypothesis. Future advancement of the field will require integrative approaches and coordinated efforts between physiologists and psychologists on this interdisciplinary topic. PMID:25589266

Analysis and Synthesis of Load Forecasting Data for Renewable Integration Studies: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steckler, N.; Florita, A.; Zhang, J.

2013-11-01

As renewable energy constitutes greater portions of the generation fleet, the importance of modeling uncertainty as part of integration studies also increases. In pursuit of optimal system operations, it is important to capture not only the definitive behavior of power plants, but also the risks associated with systemwide interactions. This research examines the dependence of load forecast errors on external predictor variables such as temperature, day type, and time of day. The analysis was utilized to create statistically relevant instances of sequential load forecasts with only a time series of historic, measured load available. The creation of such load forecastsmore » relies on Bayesian techniques for informing and updating the model, thus providing a basis for networked and adaptive load forecast models in future operational applications.« less

Data update in a land information network

NASA Astrophysics Data System (ADS)

Mullin, Robin C.

1988-01-01

The on-going update of data exchanged in a land information network is examined. In the past, major developments have been undertaken to enable the exchange of data between land information systems. A model of a land information network and the data update process have been developed. Based on these, a functional description of the database and software to perform data updating is presented. A prototype of the data update process was implemented using the ARC/INFO geographic information system. This was used to test four approaches to data updating, i.e., bulk, block, incremental, and alert updates. A bulk update is performed by replacing a complete file with an updated file. A block update requires that the data set be partitioned into blocks. When an update occurs, only the blocks which are affected need to be transferred. An incremental update approach records each feature which is added or deleted and transmits only the features needed to update the copy of the file. An alert is a marker indicating that an update has occurred. It can be placed in a file to warn a user that if he is active in an area containing markers, updated data is available. The four approaches have been tested using a cadastral data set.

78 FR 41013 - Medicare and Medicaid Programs; Home Health Prospective Payment System Rate Update for CY 2014...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... [CMS-1450-CN] RIN 0938-AR52 Medicare and Medicaid Programs; Home Health Prospective Payment System Rate Update for CY 2014, Home Health Quality Reporting Requirements, and Cost Allocation of Home Health Survey... period titled ``Medicare and Medicaid Programs; Home Health Prospective Payment System Rate Update for CY...

76 FR 9502 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-18

... [CMS-1510-F2] RIN 0938-AP88 Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2011; Changes in Certification Requirements for Home Health Agencies and Hospices; Correction... set forth an update to the Home Health Prospective Payment System (HH PPS) rates, including: The...

Acute respiratory distress syndrome: the Berlin Definition.

PubMed

Ranieri, V Marco; Rubenfeld, Gordon D; Thompson, B Taylor; Ferguson, Niall D; Caldwell, Ellen; Fan, Eddy; Camporota, Luigi; Slutsky, Arthur S

2012-06-20

The acute respiratory distress syndrome (ARDS) was defined in 1994 by the American-European Consensus Conference (AECC); since then, issues regarding the reliability and validity of this definition have emerged. Using a consensus process, a panel of experts convened in 2011 (an initiative of the European Society of Intensive Care Medicine endorsed by the American Thoracic Society and the Society of Critical Care Medicine) developed the Berlin Definition, focusing on feasibility, reliability, validity, and objective evaluation of its performance. A draft definition proposed 3 mutually exclusive categories of ARDS based on degree of hypoxemia: mild (200 mm Hg < PaO2/FIO2 ≤ 300 mm Hg), moderate (100 mm Hg < PaO2/FIO2 ≤ 200 mm Hg), and severe (PaO2/FIO2 ≤ 100 mm Hg) and 4 ancillary variables for severe ARDS: radiographic severity, respiratory system compliance (≤40 mL/cm H2O), positive end-expiratory pressure (≥10 cm H2O), and corrected expired volume per minute (≥10 L/min). The draft Berlin Definition was empirically evaluated using patient-level meta-analysis of 4188 patients with ARDS from 4 multicenter clinical data sets and 269 patients with ARDS from 3 single-center data sets containing physiologic information. The 4 ancillary variables did not contribute to the predictive validity of severe ARDS for mortality and were removed from the definition. Using the Berlin Definition, stages of mild, moderate, and severe ARDS were associated with increased mortality (27%; 95% CI, 24%-30%; 32%; 95% CI, 29%-34%; and 45%; 95% CI, 42%-48%, respectively; P < .001) and increased median duration of mechanical ventilation in survivors (5 days; interquartile [IQR], 2-11; 7 days; IQR, 4-14; and 9 days; IQR, 5-17, respectively; P < .001). Compared with the AECC definition, the final Berlin Definition had better predictive validity for mortality, with an area under the receiver operating curve of 0.577 (95% CI, 0.561-0.593) vs 0.536 (95% CI, 0.520-0.553; P < .001). This updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition. The approach of combining consensus discussions with empirical evaluation may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.

Medical Examination of Aliens--Revisions to Medical Screening Process. Final rule.

PubMed

2016-01-26

The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS), is issuing this final rule (FR) to amend its regulations governing medical examinations that aliens must undergo before they may be admitted to the United States. Based on public comment received, HHS/CDC did not make changes from the NPRM published on June 23, 2015. Accordingly, this FR will: Revise the definition of communicable disease of public health significance by removing chancroid, granuloma inguinale, and lymphogranuloma venereum as inadmissible health-related conditions for aliens seeking admission to the United States; update the notification of the health-related grounds of inadmissibility to include proof of vaccinations to align with existing requirements established by the Immigration and Nationality Act (INA); revise the definitions and evaluation criteria for mental disorders, drug abuse and drug addiction; clarify and revise the evaluation requirements for tuberculosis; clarify and revise the process for the HHS/CDC-appointed medical review board that convenes to reexamine the determination of a Class A medical condition based on an appeal; and update the titles and designations of federal agencies within the text of the regulation.

Update on the integrated histopathological and genetic classification of medulloblastoma – a practical diagnostic guideline

PubMed Central

Pietsch, Torsten; Haberler, Christine

2016-01-01

The revised WHO classification of tumors of the CNS 2016 has introduced the concept of the integrated diagnosis. The definition of medulloblastoma entities now requires a combination of the traditional histological information with additional molecular/genetic features. For definition of the histopathological component of the medulloblastoma diagnosis, the tumors should be assigned to one of the four entities classic, desmoplastic/nodular (DNMB), extensive nodular (MBEN), or large cell/anaplastic (LC/A) medulloblastoma. The genetically defined component comprises the four entities WNT-activated, SHH-activated and TP53 wildtype, SHH-activated and TP53 mutant, or non-WNT/non-SHH medulloblastoma. Robust and validated methods are available to allow a precise diagnosis of these medulloblastoma entities according to the updated WHO classification, and for differential diagnostic purposes. A combination of immunohistochemical markers including β-catenin, Yap1, p75-NGFR, Otx2, and p53, in combination with targeted sequencing and copy number assessment such as FISH analysis for MYC genes allows a precise assignment of patients for risk-adapted stratification. It also allows comparison to results of study cohorts in the past and provides a robust basis for further treatment refinement. PMID:27781424

Update on the integrated histopathological and genetic classification of medulloblastoma - a practical diagnostic guideline.

PubMed

Pietsch, Torsten; Haberler, Christine

The revised WHO classification of tumors of the CNS 2016 has introduced the concept of the integrated diagnosis. The definition of medulloblastoma entities now requires a combination of the traditional histological information with additional molecular/genetic features. For definition of the histopathological component of the medulloblastoma diagnosis, the tumors should be assigned to one of the four entities classic, desmoplastic/nodular (DNMB), extensive nodular (MBEN), or large cell/anaplastic (LC/A) medulloblastoma. The genetically defined component comprises the four entities WNT-activated, SHH-activated and TP53 wildtype, SHH-activated and TP53 mutant, or non-WNT/non-SHH medulloblastoma. Robust and validated methods are available to allow a precise diagnosis of these medulloblastoma entities according to the updated WHO classification, and for differential diagnostic purposes. A combination of immunohistochemical markers including β-catenin, Yap1, p75-NGFR, Otx2, and p53, in combination with targeted sequencing and copy number assessment such as FISH analysis for MYC genes allows a precise assignment of patients for risk-adapted stratification. It also allows comparison to results of study cohorts in the past and provides a robust basis for further treatment refinement.
.

Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders

PubMed Central

Kalberg, Wendy O.; Elliott, Amy J.; Blankenship, Jason; Buckley, David; Marais, Anna-Susan; Manning, Melanie A.; Robinson, Luther K.; Adam, Margaret P.; Abdul-Rahman, Omar; Jewett, Tamison; Coles, Claire D.; Chambers, Christina; Jones, Kenneth L.; Adnams, Colleen M.; Shah, Prachi E.; Riley, Edward P.; Charness, Michael E.; Warren, Kenneth R.; May, Philip A.

2016-01-01

The adverse effects of prenatal alcohol exposure constitute a continuum of disabilities (fetal alcohol spectrum disorders [FASD]). In 1996, the Institute of Medicine established diagnostic categories delineating the spectrum but not specifying clinical criteria by which diagnoses could be assigned. In 2005, the authors published practical guidelines operationalizing the Institute of Medicine categories, allowing for standardization of FASD diagnoses in clinical settings. The purpose of the current report is to present updated diagnostic guidelines based on a thorough review of the literature and the authors’ combined expertise based on the evaluation of >10 000 children for potential FASD in clinical settings and in epidemiologic studies in conjunction with National Institute on Alcohol Abuse and Alcoholism–funded studies, the Collaborative Initiative on Fetal Alcohol Spectrum Disorders, and the Collaboration on FASD Prevalence. The guidelines were formulated through conference calls and meetings held at National Institute on Alcohol Abuse and Alcoholism offices in Rockville, MD. Specific areas addressed include the following: precise definition of documented prenatal alcohol exposure; neurobehavioral criteria for diagnosis of fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder; revised diagnostic criteria for alcohol-related birth defects; an updated comprehensive research dysmorphology scoring system; and a new lip/philtrum guide for the white population, incorporating a 45-degree view. The guidelines reflect consensus among a large and experienced cadre of FASD investigators in the fields of dysmorphology, epidemiology, neurology, psychology, developmental/behavioral pediatrics, and educational diagnostics. Their improved clarity and specificity will guide clinicians in accurate diagnosis of infants and children prenatally exposed to alcohol. PMID:27464676

A recursive Bayesian updating model of haptic stiffness perception.

PubMed

Wu, Bing; Klatzky, Roberta L

2018-06-01

Stiffness of many materials follows Hooke's Law, but the mechanism underlying the haptic perception of stiffness is not as simple as it seems in the physical definition. The present experiments support a model by which stiffness perception is adaptively updated during dynamic interaction. Participants actively explored virtual springs and estimated their stiffness relative to a reference. The stimuli were simulations of linear springs or nonlinear springs created by modulating a linear counterpart with low-amplitude, half-cycle (Experiment 1) or full-cycle (Experiment 2) sinusoidal force. Experiment 1 showed that subjective stiffness increased (decreased) as a linear spring was positively (negatively) modulated by a half-sinewave force. In Experiment 2, an opposite pattern was observed for full-sinewave modulations. Modeling showed that the results were best described by an adaptive process that sequentially and recursively updated an estimate of stiffness using the force and displacement information sampled over trajectory and time. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

A taxonomy update for the family Polyomaviridae.

PubMed

Calvignac-Spencer, Sébastien; Feltkamp, Mariet C W; Daugherty, Matthew D; Moens, Ugo; Ramqvist, Torbjörn; Johne, Reimar; Ehlers, Bernhard

2016-06-01

Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International Committee on Taxonomy of Viruses (ICTV) Polyomaviridae Study Group designed a host- and sequence-based rationale for an updated taxonomy of the family Polyomaviridae. Applying this resulted in numerous recommendations of taxonomical revisions, which were accepted by the Executive Committee of the ICTV in December 2015. New criteria for definition and creation of polyomavirus species were established that were based on the observed distance between large T antigen coding sequences. Four genera (Alpha-, Beta, Gamma- and Deltapolyomavirus) were delineated that together include 73 species. Species naming was made as systematic as possible - most species names now consist of the binomial name of the host species followed by polyomavirus and a number reflecting the order of discovery. It is hoped that this important update of the family taxonomy will serve as a stable basis for future taxonomical developments.

Environmental Control Systems for Exploration Missions One and Two

NASA Technical Reports Server (NTRS)

Falcone, Mark A.

2017-01-01

In preparing for Exploration Missions One and Two (EM-1 & EM-2), the Ground Systems Development and Operations Program has significant updates to be made to nearly all facilities. This is all being done to accommodate the Space Launch System, which will be the world’s largest rocket in history upon fruition. Facilitating the launch of such a rocket requires an updated Vehicle Assembly Building, an upgraded Launchpad, Payload Processing Facility, and more. In this project, Environmental Control Systems across several facilities were involved, though there is a focus around the Mobile Launcher and Launchpad. Parts were ordered, analysis models were updated, design drawings were updated, and more.

Updated Lagrangian finite element formulations of various biological soft tissue non-linear material models: a comprehensive procedure and review.

PubMed

Townsend, Molly T; Sarigul-Klijn, Nesrin

2016-01-01

Simplified material models are commonly used in computational simulation of biological soft tissue as an approximation of the complicated material response and to minimize computational resources. However, the simulation of complex loadings, such as long-duration tissue swelling, necessitates complex models that are not easy to formulate. This paper strives to offer the updated Lagrangian formulation comprehensive procedure of various non-linear material models for the application of finite element analysis of biological soft tissues including a definition of the Cauchy stress and the spatial tangential stiffness. The relationships between water content, osmotic pressure, ionic concentration and the pore pressure stress of the tissue are discussed with the merits of these models and their applications.

Brazilian Guidelines for Hereditary Angioedema Management - 2017 Update Part 1: Definition, Classification and Diagnosis.

PubMed

Giavina-Bianchi, Pedro; Arruda, Luisa Karla; Aun, Marcelo V; Campos, Regis A; Chong-Neto, Herberto J; Constantino-Silva, Rosemeire N; Fernandes, Fátima R; Ferraro, Maria F; Ferriani, Mariana P L; França, Alfeu T; Fusaro, Gustavo; Garcia, Juliana F B; Komninakis, Shirley; Maia, Luana S M; Mansour, Eli; Moreno, Adriana S; Motta, Antonio A; Pesquero, João B; Portilho, Nathalia; Rosário, Nelson A; Serpa, Faradiba S; Solé, Dirceu; Takejima, Priscila; Toledo, Eliana; Valle, Solange O.R; Veronez, Camila L; Grumach, Anete S

2018-01-01

Hereditary angioedema is an autosomal dominant disease characterized by recurrent angioedema attacks with the involvement of multiple organs. The disease is unknown to many health professionals and is therefore underdiagnosed. Patients who are not adequately diagnosed and treated have an estimated mortality rate ranging from 25% to 40% due to asphyxiation by laryngeal angioedema. Intestinal angioedema is another important and incapacitating presentation that may be the main or only manifestation during an attack. In this article, a group of experts from the "Associação Brasileira de Alergia e Imunologia (ASBAI)" and the "Grupo de Estudos Brasileiro em Angioedema Hereditário (GEBRAEH)" has updated the Brazilian guidelines for the diagnosis and treatment of hereditary angioedema.

3D GIS spatial operation based on extended Euler operators

NASA Astrophysics Data System (ADS)

Xu, Hongbo; Lu, Guonian; Sheng, Yehua; Zhou, Liangchen; Guo, Fei; Shang, Zuoyan; Wang, Jing

2008-10-01

The implementation of 3 dimensions spatial operations, based on certain data structure, has a lack of universality and is not able to treat with non-manifold cases, at present. ISO/DIS 19107 standard just presents the definition of Boolean operators and set operators for topological relationship query, and OGC GeoXACML gives formal definitions for several set functions without implementation detail. Aiming at these problems, based mathematical foundation on cell complex theory, supported by non-manifold data structure and using relevant research in the field of non-manifold geometry modeling for reference, firstly, this paper according to non-manifold Euler-Poincaré formula constructs 6 extended Euler operators and inverse operators to carry out creating, updating and deleting 3D spatial elements, as well as several pairs of supplementary Euler operators to convenient for implementing advanced functions. Secondly, we change topological element operation sequence of Boolean operation and set operation as well as set functions defined in GeoXACML into combination of extended Euler operators, which separates the upper functions and lower data structure. Lastly, we develop underground 3D GIS prototype system, in which practicability and credibility of extended Euler operators faced to 3D GIS presented by this paper are validated.

Orbit transfer rocket engine technology program. Phase 2: Advanced engine study

NASA Technical Reports Server (NTRS)

Erickson, C.; Martinez, A.; Hines, B.

1987-01-01

In Phase 2 of the Advanced Engine Study, the Failure Modes and Effects Analysis (FMEA) maintenance-driven engine design, preliminary maintenance plan, and concept for space operable disconnects generated in Phase 1 were further developed. Based on the results of the vehicle contractors Orbit Transfer Vehicle (OTV) Concept Definition and System Analysis Phase A studies, minor revisions to the engine design were made. Additional refinements in the engine design were identified through further engine concept studies. These included an updated engine balance incorporating experimental heat transfer data from the Enhanced Heat Load Thrust Chamber Study and a Rao optimum nozzle contour. The preliminary maintenance plan of Phase 1 was further developed through additional studies. These included a compilation of critical component lives and life limiters and a review of the Space Shuttle Main Engine (SSME) operations and maintenance manual in order to begin outlining the overall maintenance procedures for the Orbit Transfer Vehicle Engine and identifying technology requirements for streamlining space-based operations. Phase 2 efforts also provided further definition to the advanced fluid coupling devices including the selection and preliminary design of a preferred concept and a preliminary test plan for its further development.

The Mexican consensus on chronic constipation.

PubMed

Remes-Troche, J M; Coss-Adame, E; Lopéz-Colombo, A; Amieva-Balmori, M; Carmona Sánchez, R; Charúa Guindic, L; Flores Rendón, R; Gómez Escudero, O; González Martínez, M; Icaza Chávez, M E; Morales Arámbula, M; Schmulson, M; Tamayo de la Cuesta, J L; Valdovinos, M Á; Vázquez Elizondo, G

Significant advances have been made in the knowledge and understanding of the epidemiology, pathophysiology, diagnosis, and treatment of chronic constipation, since the publication of the 2011 guidelines on chronic constipation diagnosis and treatment in Mexico from the Asociación Mexicana de Gastroenterología. To present a consensus review of the current state of knowledge about chronic constipation, providing updated information and integrating the new scientific evidence. Three general coordinators reviewed the literature published within the time frame of January 2011 and January 2017. From that information, 62 initial statements were formulated and then sent to 12 national experts for their revision. The statements were voted upon, using the Delphi system in 3 voting rounds (2 electronic and one face-to-face). The statements were classified through the GRADE system and those that reached agreement >75% were included in the consensus. The present consensus is made up of 42 final statements that provide updated knowledge, supplementing the information that had not been included in the previous guidelines. The strength of recommendation and quality (level) of evidence were established for each statement. The current definitions of chronic constipation, functional constipation, and opioid-induced constipation are given, and diagnostic strategies based on the available diagnostic methods are described. The consensus treatment recommendations were established from evidence on the roles of diet and exercise, fiber, laxatives, new drugs (such as prucalopride, lubiprostone, linaclotide, plecanatide), biofeedback therapy, and surgery. Copyright © 2018. Publicado por Masson Doyma México S.A.

Exploring the Potential of TanDEM-X Data in Rice Monitoring

NASA Astrophysics Data System (ADS)

Erten, E.

2015-12-01

In this work, phenological parameters such as growth stage, calendar estimation, crop density and yield estimation for rice fields are estimated employing TanDEM-X data. Currently, crop monitoring is country-dependent. Most countries have databases based on cadastral information and annual farmer inputs. Inaccuracies are coming from wrong or missing farmer declarations and/or coarsely updated cadastral boundary definitions. This leads to inefficient regulation of the market, frauds as well as to ecological risks. An accurate crop calendar is also missing, since farmers provide estimations in advance and there is no efficient way to know the growth status over large plantations. SAR data is of particular interest for these purposes. The proposed method includes two step approach including field detection and phenological state estimation. In the context of precise farming it is substantial to define field borders which are usually changing every cultivation period. Linking the SAR inherit properties to transplanting practice such as irrigation, the spatial database of rice-planted agricultural crops can be updated. Boundaries of agricultural fields will be defined in the database, and assignments of crops and sowing dates will be continuously updated by our monitoring system considering that sowing practice variously changes depending on the field owner decision. To define and segment rice crops, the system will make use of the fact that rice fields are characterized as flooded parcels separated by path networks composed by soil or rare grass. This natural segmentation is well detectable by inspecting low amplitude and coherence values of bistatic acquisitions. Once the field borders are defined, the phenology estimation of crops monitored at any time is the key point of monitoring. In this aspect the wavelength and the polarization option of TanDEM-X are enough to characterize the small phenological changes. The combination of bistatic interferometry and Radiative Transfer Theory (RTT) with different polarization provides a realistic description of plants including their full morphology (stalks, tillers, leaves and panicles).

75 FR 30386 - Sunshine Act Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... updates on Voting System Testing and Certification programs, including UOCAVA Pilot Program Voting Systems... Voting Systems Threat Analysis. The Board will receive updates on research and studies, including draft...

Globus Online: Climate Data Management for Small Teams

NASA Astrophysics Data System (ADS)

Ananthakrishnan, R.; Foster, I.

2013-12-01

Large and highly distributed climate data demands new approaches to data organization and lifecycle management. We need, in particular, catalogs that can allow researchers to track the location and properties of large numbers of data files, and management tools that can allow researchers to update data properties and organization during their research, move data among different locations, and invoke analysis computations on data--all as easily as if they were working with small numbers of files on their desktop computer. Both catalogs and management tools often need to be able to scale to extremely large quantities of data. When developing solutions to these problems, it is important to distinguish between the needs of (a) large communities, for whom the ability to organize published data is crucial (e.g., by implementing formal data publication processes, assigning DOIs, recording definitive metadata, providing for versioning), and (b) individual researchers and small teams, who are more frequently concerned with tracking the diverse data and computations involved in what highly dynamic and iterative research processes. Key requirements in the latter case include automated data registration and metadata extraction, ease of update, close-to-zero management overheads (e.g., no local software install); and flexible, user-managed sharing support, allowing read and write privileges within small groups. We describe here how new capabilities provided by the Globus Online system address the needs of the latter group of climate scientists, providing for the rapid creation and establishment of lightweight individual- or team-specific catalogs; the definition of logical groupings of data elements, called datasets; the evolution of catalogs, dataset definitions, and associated metadata over time, to track changes in data properties and organization as a result of research processes; and the manipulation of data referenced by catalog entries (e.g., replication of a dataset to a remote location for analysis, sharing of a dataset). Its software-as-a-service ('SaaS') architecture means that these capabilities are provided to users over the network, without a need for local software installation. In addition, Globus Online provides well defined APIs, thus providing a platform that can be leveraged to integrate the capabilities with other portals and applications. We describe early applications of these new Globus Online to climate science. We focus in particular on applications that demonstrate how Globus Online capabilities complement those of the Earth System Grid Federation (ESGF), the premier system for publication and discovery of large community datasets. ESGF already uses Globus Online mechanisms for data download. We demonstrate methods by which the two systems can be further integrated and harmonized, so that for example data collections produced within a small team can be easily published from Globus Online to ESGF for archival storage and broader access--and a Globus Online catalog can be used to organize an individual view of a subset of data held in ESGF.

ATM over hybrid fiber-coaxial cable networks: practical issues in deploying residential ATM services

NASA Astrophysics Data System (ADS)

Laubach, Mark

1996-11-01

Residential broadband access network technology based on asynchronous transfer modem (ATM) will soon reach commercial availability. The capabilities provided by ATM access network promise integrated services bandwidth available in excess of those provided by traditional twisted pair copper wire public telephone networks. ATM to the side of the home placed need quality of service capability closest to the subscriber allowing immediate support for Internet services and traditional voice telephony. Other services such as desktop video teleconferencing and enhanced server-based application support can be added as part of future evolution of the network. Additionally, advanced subscriber home networks can be supported easily. This paper presents an updated summary of the standardization efforts for the ATM over HFC definition work currently taking place in the ATM forum's residential broadband working group and the standards progress in the IEEE 802.14 cable TV media access control and physical protocol working group. This update is fundamental for establishing the foundation for delivering ATM-based integrated services via a cable TV network. An economic model for deploying multi-tiered services is presenting showing that a single-tier service is insufficient for a viable cable operator business. Finally, the use of an ATM based system lends itself well to various deployment scenarios of synchronous optical networks (SONET).

Predictive spatial modeling of narcotic crop growth patterns

USGS Publications Warehouse

Waltz, Frederick A.; Moore, D.G.

1986-01-01

Spatial models for predicting the geographic distribution of marijuana crops have been developed and are being evaluated for use in law enforcement programs. The models are based on growing condition preferences and on psychological inferences regarding grower behavior. Experiences of local law officials were used to derive the initial model, which was updated and improved as data from crop finds were archived and statistically analyzed. The predictive models are changed as crop locations are moved in response to the pressures of law enforcement. The models use spatial data in a raster geographic information system. The spatial data are derived from the U.S. Geological Survey's US GeoData, standard 7.5-minute topographic quadrangle maps, interpretations of aerial photographs, and thematic maps. Updating of cultural patterns, canopy closure, and other dynamic features is conducted through interpretation of aerial photographs registered to the 7.5-minute quadrangle base. The model is used to numerically weight various data layers that have been processed using spread functions, edge definition, and categorization. The building of the spatial data base, model development, model application, product generation, and use are collectively referred to as the Area Reduction Program (ARP). The goal of ARP is to provide law enforcement officials with tactical maps that show the most likely locations for narcotic crops.

Computer Program and User Documentation Medical Data Update System

NASA Technical Reports Server (NTRS)

Anderson, J.

1971-01-01

The update system for the NASA medical data minicomputer storage and retrieval system is described. The discussion includes general and technical specifications, a subroutine list, and programming instructions.

Definition study for variable cycle engine testbed engine and associated test program

NASA Technical Reports Server (NTRS)

Vdoviak, J. W.

1978-01-01

The product/study double bypass variable cycle engine (VCE) was updated to incorporate recent improvements. The effect of these improvements on mission range and noise levels was determined. This engine design was then compared with current existing high-technology core engines in order to define a subscale testbed configuration that simulated many of the critical technology features of the product/study VCE. Detailed preliminary program plans were then developed for the design, fabrication, and static test of the selected testbed engine configuration. These plans included estimated costs and schedules for the detail design, fabrication and test of the testbed engine and the definition of a test program, test plan, schedule, instrumentation, and test stand requirements.

Engineering test facility design definition

NASA Technical Reports Server (NTRS)

Bercaw, R. W.; Seikel, G. R.

1980-01-01

The Engineering Test Facility (ETF) is the major focus of the Department of Energy (DOE) Magnetohydrodynamics (MHD) Program to facilitate commercialization and to demonstrate the commercial operability of MHD/steam electric power. The ETF will be a fully integrated commercial prototype MHD power plant with a nominal output of 200 MW sub e. Performance of this plant is expected to meet or surpass existing utility standards for fuel, maintenance, and operating costs; plant availability; load following; safety; and durability. It is expected to meet all applicable environmental regulations. The current design concept conforming to the general definition, the basis for its selection, and the process which will be followed in further defining and updating the conceptual design.

Legal update. Definition of accident--accidental death and dismemberment--alcohol-related automobile collision--foreseeability of death as result of driving while intoxicated.

PubMed

2011-01-01

LaAsmar v. Phelps Dodge Corp. Life, Accidental Death & Dismemberment & Dependent Life Ins. Plan, 605 F3d 789, 2010 WL 1794437(10th Cir. 2010). A death caused by an alcohol-related automobile collision qualifies as an "accident" that would require payment of accidental death and dismemberment plan benefits.

Defining the culture of your practice.

PubMed

Weinstock, Donna

2014-01-01

Your practice should want patients to understand and appreciate its uniqueness and beliefs. Simply stated, the culture of your practice is the excellent care you provide and how your practice is able to achieve that excellence. Defining and sharing your culture will encourage patients to choose your practice for their healthcare. Monitoring and continually updating your definition of "culture" will help your practice thrive and maintain high standards.

Smart Currency: Defining Literacy in the Modern Age is Crucial to Building Professional Learning that Prepares Students for the Knowledge Economy

ERIC Educational Resources Information Center

Celeste, Eric

2016-01-01

Policymakers and education professionals have emphasized the importance of literacy in a global economy many times this century. The National Council of Teachers of English (NCTE) updated its own definition of 21st-century literacies, noting that "[a]s society and technology change, so does literacy. Because technology has increased the…

Partners in Play: An Adlerian Approach to Play Therapy. Third Edition

ERIC Educational Resources Information Center

Kottman, Terry; Meany-Walen, Kristin

2016-01-01

Play therapy expert Terry Kottman and her colleague Kristin Meany-Walen provide a comprehensive update to this spirited and fun text on integrating Adlerian techniques into play therapy. Clinicians, school counselors, and students will find this to be the definitive guide for using Adlerian strategies with children to foster positive growth and…

Energy-based device treatment of melasma: An update and review of the literature.

PubMed

Dunbar, Scott; Posnick, David; Bloom, Bradley; Elias, Charles; Zito, Patrick; Goldberg, David J

2017-02-01

Melasma is an acquired pigmentary disorder commonly seen in sun-exposed areas. Predominantly affecting women of childbearing age, melasma can be difficult to treat for many patients. A variety of options currently exist; however, definitive treatment remains elusive. This article provides a review of the current literature and examines in detail the various energy-based devices used to treat melasma.

Updating the Model Definition of the Gene in the Modern Genomic Era with Implications for Instruction

ERIC Educational Resources Information Center

Smith, Mike U.; Adkison, Linda R.

2010-01-01

Gericke and Hagberg (G & H, "Sci Educ" 16:849-881, 2007) recently published in this journal a thoughtful analysis of the historical progression of our understanding of the nature of the gene for use in instruction. This analysis, however, did not include the findings of the Human Genome Project (HGP), which must be included in any introductory…

Early Restoration Projects Atlas | NOAA Gulf Spill Restoration

Science.gov Websites

trustees are implementing. To view details of an individual project, click the View icon on the list below or click the project marker on the map. For definitions of the project detail click here. To highlight the location of a project from the list, click the Show on Map icon. This atlas will be updated as

History & implementation of Item Unique Identification (IUID) - Has it Improved Asset Visibility?

DTIC Science & Technology

2012-03-27

figure 3) as of November 2011 on their progress in implementing IUID38: 10 Objectives • Policy Updates • Systems Updates (AIS and ERP ...Implement SAP Enhancement Pack – Nov 2013 • Design & build LMP IUID solution – Aug 2014 • Integrate & test with Trading Partners, Army IUID...issues Objectives • Policy Updates • Systems Updates (AIS and ERP ) • Contract Compliance Rate • Physical Marking • Use of IUID Registry IUID Scorecard

Steps towards Improving GNSS Systematic Errors and Biases

NASA Astrophysics Data System (ADS)

Herring, T.; Moore, M.

2017-12-01

Four general areas of analysis method improvements, three related to data analysis models and the fourth to calibration methods, have been recommended at the recent unified analysis workshop (UAW) and we discuss aspects of these areas for improvement. The gravity fields used in the GNSS orbit integrations should be updated to match modern fields to make them consistent with the fields being used by the other IAG services. The update would include the static part of the field and a time variable component. The force models associated with radiation forces are the most uncertain and modeling of these forces can be made more consistent with the exchange of attitude information. The international GNSS service (IGS) will develop an attitude format and make attitude information available so that analysis centers can validate their models. The IGS has noted the appearance of the GPS draconitic period and harmonics of this period in time series of various geodetic products (e.g., positions and Earth orientation parameters). An updated short-period (diurnal and semidiurnal) model is needed and a method to determine the best model developed. The final area, not directly related to analysis models, is the recommendation that site dependent calibration of GNSS antennas are needed since these have a direct effect on the ITRF realization and position offsets when antennas are changed. Evaluation of the effects of the use of antenna specific phase center models will be investigated for those sites where these values are available without disturbing an existing antenna installation. Potential development of an in-situ antenna calibration system is strongly encouraged. In-situ calibration would be deployed at core sites where GNSS sites are tied to other geodetic systems. With recent expansion of the number of GPS satellites transmitting unencrypted codes on the GPS L2 frequency and the availability of software GNSS receivers in-situ calibration between an existing installation and a movable directional antenna is now more likely to generate accurate results than earlier analog switching systems. With all of these improvements, there is the expectation that there will be better agreement between the space geodetic methods thus allowing more definitive assessment and modeling of the Earth's time variable shape and gravity field.

Vulvodynia: Definition, Prevalence, Impact, and Pathophysiological Factors.

PubMed

Pukall, Caroline F; Goldstein, Andrew T; Bergeron, Sophie; Foster, David; Stein, Amy; Kellogg-Spadt, Susan; Bachmann, Gloria

2016-03-01

Vulvodynia constitutes a highly prevalent form of chronic genital pain in women, and current information regarding its definition, prevalence, impact, and pathophysiologic factors involved is needed. To update the scientific evidence published in 2010 from the Third International Consultation of Sexual Medicine pertaining to the definition, prevalence, impact, and pathophysiologic factors of women's sexual pain. An expert committee, as part of the Fourth International Consultation of Sexual Medicine, comprised of researchers and clinicians from biological and social science disciplines, reviewed the scientific evidence on the definition, prevalence, impact, and pathophysiologic factors related to chronic genital pain. A review of the definition, prevalence, impact, and pathophysiological factors involved in vulvodynia. Vulvodynia is a prevalent and highly impactful genital pain condition. Numerous factors have been implicated in its development and maintenance. What is becoming increasingly apparent is that it likely represents the end point of different factors that can differ from patient to patient. Longitudinal research is needed to shed light on risk factors involved in the expression of vulvodynia, as well as in potential subgroups of affected patients, in order to develop an empirically supported treatment algorithm. Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

Value of the SYNTAX score for periprocedural myocardial infarction according to WHO and the third universal definition of myocardial infarction: insights from the TWENTE trial.

PubMed

Tandjung, Kenneth; Lam, Ming Kai; Sen, Hanim; de Man, Frits H A F; Louwerenburg, J Hans W; Stoel, Martin G; van Houwelingen, K Gert; Linssen, Gerard C M; van der Palen, Job; Doggen, Carine J M; von Birgelen, Clemens

2016-07-20

The SYNTAX score is a tool to quantify the complexity of coronary artery disease. We investigated the relation between the SYNTAX score and the occurrence of a periprocedural myocardial infarction (PMI) according to the historical definition of the World Health Organization (WHO) and the recently updated universal definition of MI. The SYNTAX score was calculated in 1,243 patients enrolled in TWENTE, a randomised trial which assessed second-generation drug-eluting stents. PMI was defined by the WHO definition and the third universal definition of MI. Patients were divided into tertiles of the SYNTAX score: ≤7 (n=430); >7 and <15 (n=390); ≥15 (n=423). PMI according to the WHO definition occurred more frequently in patients in the highest SYNTAX score tertile (7.3% vs. 3.1% vs. 1.6%, p<0.001) compared to the mid and lowest tertile. Similar findings were seen for universal PMI (9.9% vs. 7.7% vs. 3.7%, p<0.01). After multivariate analysis, SYNTAX score was a significant independent correlate of PMI for both definitions: the highest SYNTAX score tertile had an almost five times higher risk for WHO PMI, and a three times higher risk for universal PMI. In a broad patient population treated with second-generation DES, the SYNTAX score was able to stratify the risk of PMI.

Assessment of state measures of risk-appropriate care for very low birth weight infants and recommendations for enhancing regionalized state systems.

PubMed

Nowakowski, Lindsey; Barfield, Wanda D; Kroelinger, Charlan D; Lauver, Cassie B; Lawler, Michele H; White, Vanessa A; Ramos, Lauren Raskin

2012-01-01

The goal of this study was to examine state measurements and improvements in risk-appropriate care for very low birth weight (VLBW) infants. The authors reviewed state perinatal regionalization models and levels of care to compare varying definitions between states and assess mechanisms of measurement and areas for improvement. Seven states that presented at a 2009 Association of Maternal & Child Health Programs Perinatal Regionalization Meeting were included in the assessment. Information was gathered from meeting presentations, presenters, state representatives, and state websites. Comparison of state levels of care and forms of regulation were outlined. Review of state models revealed variability in the models themselves, as well as the various mechanisms for measuring and improving risk-appropriate care. Regulation of regionalization programs, data surveillance, review of adverse events, and consideration of geography and demographics were identified as mechanisms facilitating better measurement of risk-appropriate care. Antenatal or neonatal transfer arrangements, telemedicine networks, acquisition of funding, provision of financial incentives, and patient education comprised state actions for improving risk-appropriate care. The void of explicit and updated national standards led to the current variations in definitions and models among states. State regionalization models and measures of risk-appropriate care varied greatly. These variations arose from inconsistent definitions and models of perinatal regionalization. Guidelines should be collaboratively developed by healthcare providers and public health officials for consistent and suitable measures of perinatal risk-appropriate care.

Updating energy security and environmental policy: Energy security theories revisited.

PubMed

Proskuryakova, L

2018-06-18

The energy security theories are based on the premises of sufficient and reliable supply of fossil fuels at affordable prices in centralized supply systems. Policy-makers and company chief executives develop energy security strategies based on the energy security theories and definitions that dominate in the research and policy discourse. It is therefore of utmost importance that scientists revisit these theories in line with the latest changes in the energy industry: the rapid advancement of renewables and smart grid, decentralization of energy systems, new environmental and climate challenges. The study examines the classic energy security concepts (neorealism, neoliberalism, constructivism and international political economy) and assesses if energy technology changes are taken into consideration. This is done through integrative literature review, comparative analysis, identification of 'international relations' and 'energy' research discourse with the use of big data, and case studies of Germany, China, and Russia. The paper offers suggestions for revision of energy security concepts through integration of future technology considerations. Copyright © 2018 Elsevier Ltd. All rights reserved.

Updating the planetary time scale: focus on Mars

USGS Publications Warehouse

Tanaka, Kenneth L.; Quantin-Nataf, Cathy

2013-01-01

Formal stratigraphic systems have been developed for the surface materials of the Moon, Mars, Mercury, and the Galilean satellite Ganymede. These systems are based on geologic mapping, which establishes relative ages of surfaces delineated by superposition, morphology, impact crater densities, and other relations and features. Referent units selected from the mapping determine time-stratigraphic bases and/or representative materials characteristic of events and periods for definition of chronologic units. Absolute ages of these units in some cases can be estimated using crater size-frequency data. For the Moon, the chronologic units and cratering record are calibrated by radiometric ages measured from samples collected from the lunar surface. Model ages for other cratered planetary surfaces are constructed primarily by estimating cratering rates relative to that of the Moon. Other cratered bodies with estimated surface ages include Venus and the Galilean satellites of Jupiter. New global geologic mapping and crater dating studies of Mars are resulting in more accurate and detailed reconstructions of its geologic history.

[Revision of the primary care version of the ICD-10. Mental disorders].

PubMed

Varela-González, O; López-Ibor, J J

2007-01-01

Although the difficulty of applying psychiatric classifications to primary care has been widely criticized, there have been few investigations up to now to define and systematize the real demands in regards to these nosological systems. Recently, the revised version of the Mental and Behavior Disorders Chapter of the ICD 10 has been published. The new tool is the result of an elaboration process mainly developed by a group of 971 primary care physicians coordinated by 55 psychiatrists. The project was organized into three phases: a) evaluation of the current version and collection of proposals for change; b) definition of objectives for an optimized version; and c) writing a proposal of revised text. The result is a text that is more assimilable to a diagnostic and therapeutic guide than a mere coding system, more adapted to the role that the primary care physician can play in each disorder, more up-dated (especially in the treatment section) and more specific in many aspects.

Inventory of DOT Statistical Information Systems

DOT National Transportation Integrated Search

1983-01-01

The inventory represents an update of relevant systems described in the Transportation Statistical Reference File (TSRF), coordinated with the GAO update of Congressional Sources and Systems, and the Information Collection Budget. The inventory compi...

Patch Transporter: Incentivized, Decentralized Software Patch System for WSN and IoT Environments

PubMed Central

Lee, JongHyup

2018-01-01

In the complicated settings of WSN (Wireless Sensor Networks) and IoT (Internet of Things) environments, keeping a number of heterogeneous devices updated is a challenging job, especially with respect to effectively discovering target devices and rapidly delivering the software updates. In this paper, we convert the traditional software update process to a distributed service. We set an incentive system for faithfully transporting the patches to the recipient devices. The incentive system motivates independent, self-interested transporters for helping the devices to be updated. To ensure the system correctly operates, we employ the blockchain system that enforces the commitment in a decentralized manner. We also present a detailed specification for the proposed protocol and validate it by model checking and simulations for correctness. PMID:29438337

Patch Transporter: Incentivized, Decentralized Software Patch System for WSN and IoT Environments.

PubMed

Lee, JongHyup

2018-02-13

[-12]In the complicated settings of WSN (Wireless Sensor Networks) and IoT (Internet of Things) environments, keeping a number of heterogeneous devices updated is a challenging job, especially with respect to effectively discovering target devices and rapidly delivering the software updates. In this paper, we convert the traditional software update process to a distributed service. We set an incentive system for faithfully transporting the patches to the recipient devices. The incentive system motivates independent, self-interested transporters for helping the devices to be updated. To ensure the system correctly operates, we employ the blockchain system that enforces the commitment in a decentralized manner. We also present a detailed specification for the proposed protocol and validate it by model checking and simulations for correctness.

The Anglo-Australian Planet Search XXIV: The Frequency of Jupiter Analogs

NASA Astrophysics Data System (ADS)

Wittenmyer, Robert A.; Butler, R. P.; Tinney, C. G.; Horner, Jonathan; Carter, B. D.; Wright, D. J.; Jones, H. R. A.; Bailey, J.; O'Toole, Simon J.

2016-03-01

We present updated simulations of the detectability of Jupiter analogs by the 17-year Anglo-Australian Planet Search. The occurrence rate of Jupiter-like planets that have remained near their formation locations beyond the ice line is a critical datum necessary to constrain the details of planet formation. It is also vital in our quest to fully understand how common (or rare) planetary systems like our own are in the Galaxy. From a sample of 202 solar-type stars, and correcting for imperfect detectability on a star-by-star basis, we derive a frequency of {6.2}-1.6+2.8% for giant planets in orbits from 3 to 7 au. When a consistent definition of “Jupiter analog” is used, our results are in agreement with those from other legacy radial-velocity surveys.

German guidelines for the diagnosis and therapy of localized scleroderma.

PubMed

Kreuter, Alexander; Krieg, Thomas; Worm, Margitta; Wenzel, Jörg; Moinzadeh, Pia; Kuhn, Annegret; Aberer, Elisabeth; Scharffetter-Kochanek, Karin; Horneff, Gerd; Reil, Emma; Weberschock, Tobias; Hunzelmann, Nicolas

2016-02-01

Localized scleroderma designates a heterogeneous group of sclerotic skin disorders. Depending on the subtype, severity, and site affected, adjacent structures such as adipose tissue, muscles, joints, and bones may be involved. This is an update of the existing German AWMF (Association of the Scientific Medical Societies in Germany) guidelines (classification: S2k). These guidelines provide an overview of the definition, epidemiology, classification, pathogenesis, laboratory workup, histopathology, clinical scoring systems, as well as imaging and device-based workup of localized scleroderma. Moreover, consensus-based recommendations are given on the management of localized scleroderma depending on its clinical subtype. Treatment recommendations are presented in a therapeutic algorithm. No financial support was given by any pharmaceutical company. The guidelines are valid until July 2019. © 2016 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.

The CIPM list of recommended frequency standard values: guidelines and procedures

NASA Astrophysics Data System (ADS)

Riehle, Fritz; Gill, Patrick; Arias, Felicitas; Robertsson, Lennart

2018-04-01

A list of standard reference frequency values (LoF) of quantum transitions from the microwave to the optical regime has been recommended by the International Committee for Weights and Measures (Comité international des poids et mesures, CIPM) for use in basic research, technology, and for the metrology of time, frequency and length. The CIPM LoF contains entries that are recommended as secondary representations of the second in the International System of Units, and entries that can be used to serve as realizations of the definition of the metre. The historical perspective that led to the CIPM LoF is outlined. Procedures have been developed for updating existing, and validating new, entries into the CIPM LoF. The CIPM LoF might serve as an entry for a future redefinition of the second by an optical transition.

DataHub: Science data management in support of interactive exploratory analysis

NASA Technical Reports Server (NTRS)

Handley, Thomas H., Jr.; Rubin, Mark R.

1993-01-01

The DataHub addresses four areas of significant needs: scientific visualization and analysis; science data management; interactions in a distributed, heterogeneous environment; and knowledge-based assistance for these functions. The fundamental innovation embedded within the DataHub is the integration of three technologies, viz. knowledge-based expert systems, science visualization, and science data management. This integration is based on a concept called the DataHub. With the DataHub concept, science investigators are able to apply a more complete solution to all nodes of a distributed system. Both computational nodes and interactives nodes are able to effectively and efficiently use the data services (access, retrieval, update, etc), in a distributed, interdisciplinary information system in a uniform and standard way. This allows the science investigators to concentrate on their scientific endeavors, rather than to involve themselves in the intricate technical details of the systems and tools required to accomplish their work. Thus, science investigators need not be programmers. The emphasis on the definition and prototyping of system elements with sufficient detail to enable data analysis and interpretation leading to information. The DataHub includes all the required end-to-end components and interfaces to demonstrate the complete concept.

DataHub - Science data management in support of interactive exploratory analysis

NASA Technical Reports Server (NTRS)

Handley, Thomas H., Jr.; Rubin, Mark R.

1993-01-01

DataHub addresses four areas of significant need: scientific visualization and analysis; science data management; interactions in a distributed, heterogeneous environment; and knowledge-based assistance for these functions. The fundamental innovation embedded within the DataHub is the integration of three technologies, viz. knowledge-based expert systems, science visualization, and science data management. This integration is based on a concept called the DataHub. With the DataHub concept, science investigators are able to apply a more complete solution to all nodes of a distributed system. Both computational nodes and interactive nodes are able to effectively and efficiently use the data services (access, retrieval, update, etc.) in a distributed, interdisciplinary information system in a uniform and standard way. This allows the science investigators to concentrate on their scientific endeavors, rather than to involve themselves in the intricate technical details of the systems and tools required to accomplish their work. Thus, science investigators need not be programmers. The emphasis is on the definition and prototyping of system elements with sufficient detail to enable data analysis and interpretation leading to information. The DataHub includes all the required end-to-end components and interfaces to demonstrate the complete concept.

SP-100 ground engineering system test site description and progress update

NASA Astrophysics Data System (ADS)

Baxter, William F.; Burchell, Gail P.; Fitzgibbon, Davis G.; Swita, Walter R.

1991-01-01

The SP-100 Ground Engineering System Test Site will provide the facilities for the testing of an SP-100 reactor, which is technically prototypic of the generic design for producing 100 kilowatts of electricity. This effort is part of the program to develop a compact, space-based power system capable of producing several hundred kilowatts of electrical power. The test site is located on the U.S. Department of Energy's Hanford Site near Richland, Washington. The site is minimizing capital equipment costs by utilizing existing facilities and equipment to the maximum extent possible. The test cell is located in a decommissioned reactor containment building, and the secondary sodium cooling loop will use equipment from the Fast Flux Test Facility plant which has never been put into service. Modifications to the facility and special equipment are needed to accommodate the testing of the SP-100 reactor. Definitive design of the Ground Engineering System Test Site facility modifications and systems is in progress. The design of the test facility and the testing equipment will comply with the regulations and specifications of the U.S. Department of Energy and the State of Washington.

Email Updates About FASTSim | Transportation Research | NREL

Science.gov Websites

Email Updates About FASTSim Email Updates about FASTSim Subscribe Please provide the following information to subscribe for email updates about FASTSim, the Future Automotive Systems Technology Simulator . * indicates required Email Address: * Name (first and last): Organization/Affiliation: Subscribe

Report on the International Conference on Emergency Health Care Development.

PubMed Central

Dines, G B

1990-01-01

Emergency medical services (EMS) provide rescue, field stabilization, transportation to medical facilities, and definitive care for persons experiencing medical emergencies. In order to advance worldwide development and refinement of EMS systems, and their integration with emergency preparedness and response programs, the International Conference on Emergency Health Care Development was held in Crystal City, Arlington, VA, August 15-19, 1989. The conference was supported by the Department of Health and Human Services and its Health Resources and Services Administration; the Department of Transportation and its National Highway Traffic and Safety Administration; and the Pan American Health Organization. Objectives of the conference were to clarify linkages between various levels of emergency response, to present methods for developing or improving EMS systems within societies with different resources, to demonstrate processes by which EMS systems have been developed, and to propose international emergency health care development goals. Topics included development of services in developing nations, case studies of underdeveloped countries' responses to natural disasters, and a method for updating disaster response through use of available medical resources. PMID:1968669

Medicare program; FY 2015 hospice wage index and payment rate update; hospice quality reporting requirements and process and appeals for Part D payment for drugs for beneficiaries enrolled in hospice. Final rule.

PubMed

2014-08-22

This final rule will update the hospice payment rates and the wage index for fiscal year (FY) 2015 and continue the phase-out of the wage index budget neutrality adjustment factor (BNAF). This rule provides an update on hospice payment reform analyses, potential definitions of "terminal illness'' and "related conditions,'' and information on potential processes and appeals for Part D payment for drugs while beneficiaries are under a hospice election. This rule will specify timeframes for filing the notice of election and the notice of termination/revocation; add the attending physician to the hospice election form, and require hospices to document changes to the attending physician; require hospices to complete their hospice aggregate cap determinations within 5 months after the cap year ends, and remit any overpayments; and update the hospice quality reporting program. In addition, this rule will provide guidance on determining hospice eligibility; information on the delay in the implementation of the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM); and will further clarify how hospices are to report diagnoses on hospice claims. Finally, the rule will make a technical regulations text change.

Updated evidence-based clinical practice guidelines for the diagnosis and management of melanoma: definitive excision margins for primary cutaneous melanoma.

PubMed

Sladden, Michael J; Nieweg, Omgo E; Howle, Julie; Coventry, Brendon J; Thompson, John F

2018-02-19

Definitive management of primary cutaneous melanoma consists of surgical excision of the melanoma with the aim of curing the patient. The melanoma is widely excised together with a safety margin of surrounding skin and subcutaneous tissue, after the diagnosis and Breslow thickness have been established by histological assessment of the initial excision biopsy specimen. Sentinel lymph node biopsy should be discussed for melanomas ≥ 1 mm thickness (≥ 0.8 mm if other high risk features) in which case lymphoscintigraphy must be performed before wider excision of the primary melanoma site. The 2008 evidence-based clinical practice guidelines for the management of melanoma (http://www.cancer.org.au/content/pdf/HealthProfessionals/ClinicalGuidelines/ClinicalPracticeGuidelines-ManagementofMelanoma.pdf) are currently being revised and updated in a staged process by a multidisciplinary working party established by Cancer Council Australia. The guidelines for definitive excision margins for primary melanomas have been revised as part of this process. Main recommendations: The recommendations for definitive wide local excision of primary cutaneous melanoma are: melanoma in situ: 5-10 mm margins invasive melanoma (pT1) ≤ 1.0 mm thick: 1 cm margins invasive melanoma (pT2) 1.01-2.00 mm thick: 1-2 cm margins invasive melanoma (pT3) 2.01-4.00 mm thick: 1-2 cm margins invasive melanoma (pT4) > 4.0 mm thick: 2 cm margins Changes in management as a result of the guideline: Based on currently available evidence, excision margins for invasive melanoma have been left unchanged compared with the 2008 guidelines. However, melanoma in situ should be excised with 5-10 mm margins, with the aim of achieving complete histological clearance. Minimum clearances from all margins should be assessed and stated. Consideration should be given to further excision if necessary; positive or close histological margins are unacceptable.

Aircraft engine sensor fault diagnostics using an on-line OBEM update method.

PubMed

Liu, Xiaofeng; Xue, Naiyu; Yuan, Ye

2017-01-01

This paper proposed a method to update the on-line health reference baseline of the On-Board Engine Model (OBEM) to maintain the effectiveness of an in-flight aircraft sensor Fault Detection and Isolation (FDI) system, in which a Hybrid Kalman Filter (HKF) was incorporated. Generated from a rapid in-flight engine degradation, a large health condition mismatch between the engine and the OBEM can corrupt the performance of the FDI. Therefore, it is necessary to update the OBEM online when a rapid degradation occurs, but the FDI system will lose estimation accuracy if the estimation and update are running simultaneously. To solve this problem, the health reference baseline for a nonlinear OBEM was updated using the proposed channel controller method. Simulations based on the turbojet engine Linear-Parameter Varying (LPV) model demonstrated the effectiveness of the proposed FDI system in the presence of substantial degradation, and the channel controller can ensure that the update process finishes without interference from a single sensor fault.

Aircraft engine sensor fault diagnostics using an on-line OBEM update method

PubMed Central

Liu, Xiaofeng; Xue, Naiyu; Yuan, Ye

2017-01-01

This paper proposed a method to update the on-line health reference baseline of the On-Board Engine Model (OBEM) to maintain the effectiveness of an in-flight aircraft sensor Fault Detection and Isolation (FDI) system, in which a Hybrid Kalman Filter (HKF) was incorporated. Generated from a rapid in-flight engine degradation, a large health condition mismatch between the engine and the OBEM can corrupt the performance of the FDI. Therefore, it is necessary to update the OBEM online when a rapid degradation occurs, but the FDI system will lose estimation accuracy if the estimation and update are running simultaneously. To solve this problem, the health reference baseline for a nonlinear OBEM was updated using the proposed channel controller method. Simulations based on the turbojet engine Linear-Parameter Varying (LPV) model demonstrated the effectiveness of the proposed FDI system in the presence of substantial degradation, and the channel controller can ensure that the update process finishes without interference from a single sensor fault. PMID:28182692

Imputatoin and Model-Based Updating Technique for Annual Forest Inventories

Treesearch

Ronald E. McRoberts

2001-01-01

The USDA Forest Service is developing an annual inventory system to establish the capability of producing annual estimates of timber volume and related variables. The inventory system features measurement of an annual sample of field plots with options for updating data for plots measured in previous years. One imputation and two model-based updating techniques are...

International Geomagnetic Reference Field: the 12th generation

NASA Astrophysics Data System (ADS)

Thébault, Erwan; Finlay, Christopher C.; Beggan, Ciarán D.; Alken, Patrick; Aubert, Julien; Barrois, Olivier; Bertrand, Francois; Bondar, Tatiana; Boness, Axel; Brocco, Laura; Canet, Elisabeth; Chambodut, Aude; Chulliat, Arnaud; Coïsson, Pierdavide; Civet, François; Du, Aimin; Fournier, Alexandre; Fratter, Isabelle; Gillet, Nicolas; Hamilton, Brian; Hamoudi, Mohamed; Hulot, Gauthier; Jager, Thomas; Korte, Monika; Kuang, Weijia; Lalanne, Xavier; Langlais, Benoit; Léger, Jean-Michel; Lesur, Vincent; Lowes, Frank J.; Macmillan, Susan; Mandea, Mioara; Manoj, Chandrasekharan; Maus, Stefan; Olsen, Nils; Petrov, Valeriy; Ridley, Victoria; Rother, Martin; Sabaka, Terence J.; Saturnino, Diana; Schachtschneider, Reyko; Sirol, Olivier; Tangborn, Andrew; Thomson, Alan; Tøffner-Clausen, Lars; Vigneron, Pierre; Wardinski, Ingo; Zvereva, Tatiana

2015-05-01

The 12th generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2014 by the Working Group V-MOD appointed by the International Association of Geomagnetism and Aeronomy (IAGA). It updates the previous IGRF generation with a definitive main field model for epoch 2010.0, a main field model for epoch 2015.0, and a linear annual predictive secular variation model for 2015.0-2020.0. Here, we present the equations defining the IGRF model, provide the spherical harmonic coefficients, and provide maps of the magnetic declination, inclination, and total intensity for epoch 2015.0 and their predicted rates of change for 2015.0-2020.0. We also update the magnetic pole positions and discuss briefly the latest changes and possible future trends of the Earth's magnetic field.

Compendium of animal rabies prevention and control, 2011.

PubMed

2011-11-04

Rabies has one of the highest case-fatality ratios of any infectious disease. This report provides recommendations for public health officials, veterinarians, animal control officials, and other parties engaged in rabies prevention and control activities and should serve as the basis for standardizing procedures among jurisdictions. The recommendations regarding domestic animal vaccination, management of animals exposed to rabies, and management of animals that bite humans are the core elements of animal rabies control and human rabies prevention. These updated 2011 guidelines include the national case definition for animal rabies and clarify the role of the CDC rabies laboratory in providing confirmatory testing of suspect animals. The table of rabies vaccines licensed and marketed in the United States has been updated, and additional references have been included to provide scientific support for information in this report.

Definition of an XML markup language for clinical laboratory procedures and comparison with generic XML markup.

PubMed

Saadawi, Gilan M; Harrison, James H

2006-10-01

Clinical laboratory procedure manuals are typically maintained as word processor files and are inefficient to store and search, require substantial effort for review and updating, and integrate poorly with other laboratory information. Electronic document management systems could improve procedure management and utility. As a first step toward building such systems, we have developed a prototype electronic format for laboratory procedures using Extensible Markup Language (XML). Representative laboratory procedures were analyzed to identify document structure and data elements. This information was used to create a markup vocabulary, CLP-ML, expressed as an XML Document Type Definition (DTD). To determine whether this markup provided advantages over generic markup, we compared procedures structured with CLP-ML or with the vocabulary of the Health Level Seven, Inc. (HL7) Clinical Document Architecture (CDA) narrative block. CLP-ML includes 124 XML tags and supports a variety of procedure types across different laboratory sections. When compared with a general-purpose markup vocabulary (CDA narrative block), CLP-ML documents were easier to edit and read, less complex structurally, and simpler to traverse for searching and retrieval. In combination with appropriate software, CLP-ML is designed to support electronic authoring, reviewing, distributing, and searching of clinical laboratory procedures from a central repository, decreasing procedure maintenance effort and increasing the utility of procedure information. A standard electronic procedure format could also allow laboratories and vendors to share procedures and procedure layouts, minimizing duplicative word processor editing. Our results suggest that laboratory-specific markup such as CLP-ML will provide greater benefit for such systems than generic markup.

Further Automate Planned Cluster Maintenance to Minimize System Downtime during Maintenance Windows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Springmeyer, R.

This report documents the integration and testing of the automated update process of compute clusters in LC to minimize impact to user productivity. Description: A set of scripts will be written and deployed to further standardize cluster maintenance activities and minimize downtime during planned maintenance windows. Completion Criteria: When the scripts have been deployed and used during planned maintenance windows and a timing comparison is completed between the existing process and the new more automated process, this milestone is complete. This milestone was completed on Aug 23, 2016 on the new CTS1 cluster called Jade when a request to upgrademore » the version of TOSS 3 was initiated while SWL jobs and normal user jobs were running. Jobs that were running when the update to the system began continued to run to completion. New jobs on the cluster started on the new release of TOSS 3. No system administrator action was required. Current update procedures in TOSS 2 begin by killing all users jobs. Then all diskfull nodes are updated, which can take a few hours. Only after the updates are applied are all nodes are rebooted, and then finally put back into service. A system administrator is required for all steps. In terms of human time spent during a cluster OS update, the TOSS 3 automated procedure on Jade took 0 FTE hours. Doing the same update without the Toss Update Tool would have required 4 FTE hours.« less

An updated Asia Pacific Consensus Recommendations on colorectal cancer screening.

PubMed

Sung, J J Y; Ng, S C; Chan, F K L; Chiu, H M; Kim, H S; Matsuda, T; Ng, S S M; Lau, J Y W; Zheng, S; Adler, S; Reddy, N; Yeoh, K G; Tsoi, K K F; Ching, J Y L; Kuipers, E J; Rabeneck, L; Young, G P; Steele, R J; Lieberman, D; Goh, K L

2015-01-01

Since the publication of the first Asia Pacific Consensus on Colorectal Cancer (CRC) in 2008, there are substantial advancements in the science and experience of implementing CRC screening. The Asia Pacific Working Group aimed to provide an updated set of consensus recommendations. Members from 14 Asian regions gathered to seek consensus using other national and international guidelines, and recent relevant literature published from 2008 to 2013. A modified Delphi process was adopted to develop the statements. Age range for CRC screening is defined as 50-75 years. Advancing age, male, family history of CRC, smoking and obesity are confirmed risk factors for CRC and advanced neoplasia. A risk-stratified scoring system is recommended for selecting high-risk patients for colonoscopy. Quantitative faecal immunochemical test (FIT) instead of guaiac-based faecal occult blood test (gFOBT) is preferred for average-risk subjects. Ancillary methods in colonoscopy, with the exception of chromoendoscopy, have not proven to be superior to high-definition white light endoscopy in identifying adenoma. Quality of colonoscopy should be upheld and quality assurance programme should be in place to audit every aspects of CRC screening. Serrated adenoma is recognised as a risk for interval cancer. There is no consensus on the recruitment of trained endoscopy nurses for CRC screening. Based on recent data on CRC screening, an updated list of recommendations on CRC screening is prepared. These consensus statements will further enhance the implementation of CRC screening in the Asia Pacific region. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Update of the mortality study of workers exposed to polychlorinated biphenyls (Pcbs) in two Italian capacitor manufacturing plants.

PubMed

Pesatori, Angela Cecilia; Grillo, P; Consonni, D; Caironi, M; Sampietro, G; Olivari, Leonella; Ghisleni, Silvia; Bertazzi, P A

2013-01-01

PCB carcinogenicity to humans is still controversial. Cohort mortality studies in PCB-exposed workers reported elevated risks for the following causes of death: liver, stomach, digestive, brain, prostate cancers and non-Hodgkin lymphoma. The purpose of this study was to update as of December 2006 the mortality experience of two Italian cohorts of workers employed in the manufacture of capacitors impregnated with PCBs. Age-gender-and calendar period adjusted Standardized Mortality Ratios (SMRs) and 95% Confidence Intervals (CI) were calculated using regional rates. Analyses by duration of employment and time since first employment were performed Results: Vital status was ascertained for 98.9% of the study subjects. Mortality from biliary tract cancer among males (SMR 3.91; 95%CI 1.47-10.41), digestive cancer "not otherwise specified" in the whole cohort (SMR 2.54; 95%CI 1.21-5.34), and brain cancer in Plant I (SMR 2.13; 95%CI 1.02-4.48), were significantly increased. Increased risks were also observed for Hodgkin's and non-Hodgkin lymphoma. No linear associations between mortality and duration of employment or latency were observed for these cancers. Mortality from stomach cancer did not differ from expectation in the whole cohort, however an increasing risk with increasing duration of employment was detected (p for trend=0.02). The current update suggests possibly increased cancer risks in PCB-exposed workers, affecting in particular the digestive system, brain, and lymphohemopoietic tissue. However the limited sample size, the lack of clear trends with duration of employment or with latency period, preclude to derive definite conclusions about PCB exposure and the increased cancer risks.

Treatment of Febrile Neutropenia and Prophylaxis in Hematologic Malignancies: A Critical Review and Update

PubMed Central

Villafuerte-Gutierrez, Paola; Villalon, Lucia; Losa, Juan E.; Henriquez-Camacho, Cesar

2014-01-01

Febrile neutropenia is one of the most serious complications in patients with haematological malignancies and chemotherapy. A prompt identification of infection and empirical antibiotic therapy can prolong survival. This paper reviews the guidelines about febrile neutropenia in the setting of hematologic malignancies, providing an overview of the definition of fever and neutropenia, and categories of risk assessment, management of infections, and prophylaxis. PMID:25525436

BARTER: Behavior Profile Exchange for Behavior-Based Admission and Access Control in MANETs

NASA Astrophysics Data System (ADS)

Frias-Martinez, Vanessa; Stolfo, Salvatore J.; Keromytis, Angelos D.

Mobile Ad-hoc Networks (MANETs) are very dynamic networks with devices continuously entering and leaving the group. The highly dynamic nature of MANETs renders the manual creation and update of policies associated with the initial incorporation of devices to the MANET (admission control) as well as with anomaly detection during communications among members (access control) a very difficult task. In this paper, we present BARTER, a mechanism that automatically creates and updates admission and access control policies for MANETs based on behavior profiles. BARTER is an adaptation for fully distributed environments of our previously introduced BB-NAC mechanism for NAC technologies. Rather than relying on a centralized NAC enforcer, MANET members initially exchange their behavior profiles and compute individual local definitions of normal network behavior. During admission or access control, each member issues an individual decision based on its definition of normalcy. Individual decisions are then aggregated via a threshold cryptographic infrastructure that requires an agreement among a fixed amount of MANET members to change the status of the network. We present experimental results using content and volumetric behavior profiles computed from the ENRON dataset. In particular, we show that the mechanism achieves true rejection rates of 95% with false rejection rates of 9%.

Earth Observing System Covariance Realism Updates

NASA Technical Reports Server (NTRS)

Ojeda Romero, Juan A.; Miguel, Fred

2017-01-01

This presentation will be given at the International Earth Science Constellation Mission Operations Working Group meetings June 13-15, 2017 to discuss the Earth Observing System Covariance Realism updates.

Evaluation of Teachers and Leaders. State Implementation of College- and Career-Readiness Standards

ERIC Educational Resources Information Center

Anderson, Kimberly; Mira, Mary Elizabeth

2015-01-01

By 2012, all of the states in this study had started implementing new or revised teacher and leader evaluation systems. The systems include many and varying updates. In some cases, the updates were designed to meet conditions for a state's "Race to the Top" grant. In others, the updates were made to meet conditions for a state's waiver…

Life sciences payload definition and integration study. Volume 4: Appendix, costs, and data management requirements of the dedicated 30-day laboratory. [carry-on laboratory for Spacelab

NASA Technical Reports Server (NTRS)

1974-01-01

The results of the updated 30-day life sciences dedicated laboratory scheduling and costing activities are documented, and the 'low cost' methodology used to establish individual equipment item costs is explained in terms of its allowances for equipment that is commerical off-the-shelf, modified commercial, and laboratory prototype; a method which significantly lowers program costs. The costs generated include estimates for non-recurring development, recurring production, and recurring operations costs. A cost for a biomedical emphasis laboratory and a Delta cost to provide a bioscience and technology laboratory were also generated. All cost reported are commensurate with the design and schedule definitions available.

Optics Program Simplifies Analysis and Design

NASA Technical Reports Server (NTRS)

2007-01-01

Engineers at Goddard Space Flight Center partnered with software experts at Mide Technology Corporation, of Medford, Massachusetts, through a Small Business Innovation Research (SBIR) contract to design the Disturbance-Optics-Controls-Structures (DOCS) Toolbox, a software suite for performing integrated modeling for multidisciplinary analysis and design. The DOCS Toolbox integrates various discipline models into a coupled process math model that can then predict system performance as a function of subsystem design parameters. The system can be optimized for performance; design parameters can be traded; parameter uncertainties can be propagated through the math model to develop error bounds on system predictions; and the model can be updated, based on component, subsystem, or system level data. The Toolbox also allows the definition of process parameters as explicit functions of the coupled model and includes a number of functions that analyze the coupled system model and provide for redesign. The product is being sold commercially by Nightsky Systems Inc., of Raleigh, North Carolina, a spinoff company that was formed by Mide specifically to market the DOCS Toolbox. Commercial applications include use by any contractors developing large space-based optical systems, including Lockheed Martin Corporation, The Boeing Company, and Northrup Grumman Corporation, as well as companies providing technical audit services, like General Dynamics Corporation

Considerations for the Next Revision of NASA's Space Telecommunications Radio System Architecture

NASA Technical Reports Server (NTRS)

Johnson, Sandra K.; Handler, Louis M.; Briones, Janette C.

2016-01-01

Development of NASA's Software Defined Radio architecture, the Space Telecommunication Radio System (STRS), was initiated in 2004 with a goal of reducing the cost, risk and schedule when implementing Software Defined Radios (SDR) for National Aeronautics and Space Administration (NASA) space missions. Since STRS was first flown in 2012 on three Software Defined Radios on the Space Communication and Navigation (SCaN) Testbed, only minor changes have been made to the architecture. Multiple entities have since implemented the architecture and provided significant feedback for consideration for the next revision of the standard. The focus for the first set of updates to the architecture is items that enhance application portability. Items that require modifications to existing applications before migrating to the updated architecture will only be considered if there is compelling reasons to make the change. The significant suggestions that were further evaluated for consideration include expanding and clarifying the timing Application Programming Interfaces (APIs), improving handle name and identification (ID) definitions and use, and multiple items related to implementation of STRS Devices. In addition to ideas suggested while implementing STRS, SDR technology has evolved significantly and this impact to the architecture needs to be considered. These include incorporating cognitive concepts - learning from past decisions and making new decisions that the radio can act upon. SDRs are also being developed that do not contain a General Purpose Module - which is currently required for the platform to be STRS compliant. The purpose of this paper is to discuss the comments received, provide a summary of the evaluation considerations, and examine planned dispositions.

The Propulsive Small Expendable Deployer System (ProSEDS)

NASA Technical Reports Server (NTRS)

Lorenzini, Enrico C.; Estes, Robert D.; Cosmo, Mario L.

2001-01-01

This is the Annual Report #2 entitled "The Propulsive Small Expendable Deployer System (ProSEDS)" prepared by the Smithsonian Astrophysical Observatory for NASA Marshall Space Flight Center. This report covers the period of activity from 1 August 2000 through 30 July 2001. The topics include: 1) Updated System Performance; 2) Mission Analysis; 3) Updated Dynamics Reference Mission; 4) Updated Deployment Control Profiles and Simulations; 5) Comparison of ED tethers and electrical thrusters; 6) Kalman filters for mission estimation; and 7) Delivery of interactive software for ED tethers.

Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms.

PubMed

Rubinsky-Elefant, G; Hirata, C E; Yamamoto, J H; Ferreira, M U

2010-01-01

Although human toxocariasis ranks among the most common zoonotic infections worldwide, it remains relatively unknown to the public. The causal agents are the nematode parasites Toxocara canis and T. cati, whose definitive hosts are dogs and cats, respectively. When embryonated eggs are accidentally ingested by humans, larvae hatch in the small intestine, penetrate the intestinal wall and migrate, via the bloodstream, to the liver, lungs, muscles, eye and central nervous system. Although most human infections are asymptomatic, two well-defined clinical syndromes are classically recognised: visceral larva migrans (a systemic disease caused by larval migration through major organs) and ocular larva migrans (a disease limited to the eyes and optic nerves). Two less-severe syndromes have recently been described, one mainly in children (covert toxocariasis) and the other mainly in adults (common toxocariasis). Here, the current laboratory diagnosis, epidemiology and main clinical features of both the systemic and ocular forms of human toxocariasis are reviewed. New developments in serological diagnosis are described, the available seroprevalence data are analysed, and the results of relevant clinical studies that have been published over the last decade are explored, to provide an updated overview of this neglected but highly prevalent human infection.

Guidance system operations plan for manned LM earth orbital and lunar missions using program luminary 1E. Section 2: Data links

NASA Technical Reports Server (NTRS)

Hamilton, M. H.

1972-01-01

Data links for the guidance system of manned lunar module orbital and lunar missions are presented. Subjects discussed are: (1) digital uplink to lunar module, (2) lunar module liftoff time increment, (3) lunar module contiguous block update, (4) lunar module scatter update, (5) lunar module digital downlink, and (6) absolute addresses for update program.

76 FR 38742 - Seventh Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

... Control Systems (Update to DO-230B): Agenda July 15, 2011 Welcome/Introductions/Administrative Remarks... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to...

Dual Systems for Spatial Updating in Immediate and Retrieved Environments: Evidence from Bias Analysis.

PubMed

Liu, Chuanjun; Xiao, Chengli

2018-01-01

The spatial updating and memory systems are employed during updating in both the immediate and retrieved environments. However, these dual systems seem to work differently, as the difference of pointing latency and absolute error between the two systems vary across environments. To verify this issue, the present study employed the bias analysis of signed errors based on the hypothesis that the transformed representation will bias toward the original one. Participants learned a spatial layout and then either stayed in the learning location or were transferred to a neighboring room directly or after being disoriented. After that, they performed spatial judgments from perspectives aligned with the learning direction, aligned with the direction they faced during the test, or a novel direction misaligned with the two above-mentioned directions. The patterns of signed error bias were consistent across environments. Responses for memory aligned perspectives were unbiased, whereas responses for sensorimotor aligned perspectives were biased away from the memory aligned perspective, and responses for misaligned perspectives were biased toward sensorimotor aligned perspectives. These findings indicate that the spatial updating system is consistently independent of the spatial memory system regardless of the environments, but the updating system becomes less accessible as the environment changes from immediate to a retrieved one.

Dual Systems for Spatial Updating in Immediate and Retrieved Environments: Evidence from Bias Analysis

PubMed Central

Liu, Chuanjun; Xiao, Chengli

2018-01-01

The spatial updating and memory systems are employed during updating in both the immediate and retrieved environments. However, these dual systems seem to work differently, as the difference of pointing latency and absolute error between the two systems vary across environments. To verify this issue, the present study employed the bias analysis of signed errors based on the hypothesis that the transformed representation will bias toward the original one. Participants learned a spatial layout and then either stayed in the learning location or were transferred to a neighboring room directly or after being disoriented. After that, they performed spatial judgments from perspectives aligned with the learning direction, aligned with the direction they faced during the test, or a novel direction misaligned with the two above-mentioned directions. The patterns of signed error bias were consistent across environments. Responses for memory aligned perspectives were unbiased, whereas responses for sensorimotor aligned perspectives were biased away from the memory aligned perspective, and responses for misaligned perspectives were biased toward sensorimotor aligned perspectives. These findings indicate that the spatial updating system is consistently independent of the spatial memory system regardless of the environments, but the updating system becomes less accessible as the environment changes from immediate to a retrieved one. PMID:29467698

Trauma patients meeting both Centers for Disease Control and Prevention's definitions for ventilator-associated pneumonia had worse outcomes than those meeting only one.

PubMed

Younan, Duraid; Griffin, Russell; Swain, Thomas; Pittet, Jean-Francois; Camins, Bernard

2017-08-01

The Centers for Disease Control and Prevention's National Healthcare Safety Network (NHSN) replaced its old definition for ventilator-associated pneumonia (VAP) with the ventilator-associated events algorithm in 2013. We sought to compare the outcome of trauma patients meeting the definitions for VAP in the two modules. Trauma patients with blunt or penetrating injuries and with at least 2 d of ventilator support were identified from the trauma registry from 2013 to 2014. VAP was determined using two methods: (1) VAP as defined by the "old," clinically based NHSN definition and (2) possible VAP as defined by the updated "new" NHSN definition. Cohen's kappa statistic was determined to compare the two definitions for VAP. To compare demographic and clinical outcomes, the chi-square and Student's t-tests were used for categorical and continuous variables, respectively. From 2013 to 2014, there were 1165 trauma patients admitted who had at least 2 d of ventilator support. Seventy-eight patients (6.6%) met the "new" NHSN definition for possible VAP, 361 patients (30.9%) met the "old" definition of VAP, and 68 patients (5.8%) met both definitions. The kappa statistic between VAP as defined by the "new" and "old" definitions was 0.22 (95% confidence interval, 0.17-0.27). There were no differences in age, gender, race, or injury severity score when comparing patients who met the different definitions. Those satisfying both definitions had longer ventilator support days (P = 0.0009), intensive care unit length of stay (LOS; P = 0.0003), and hospital LOS (P = 0.0344) when compared with those meeting only one definition. There was no difference in mortality for those meeting both and those meeting the old definition for VAP; patients meeting both definitions had higher respiratory rate at arrival (P = 0.0178). There was no difference in mortality between patients meeting the "old" and "new" NHSN definitions for VAP; those who met "both" definitions had longer ventilator support days, intensive care unit, and hospital LOS. Copyright © 2017 Elsevier Inc. All rights reserved.

78 FR 79694 - Privacy Act of 1974; Notice of an Updated System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-31

... analysts and managers. System information also may be used: a. In any legal proceeding, where pertinent, to...] Privacy Act of 1974; Notice of an Updated System of Records AGENCY: General Services Administration. ACTION: Notice. [[Page 79695

The Propulsive Small Expendable Deployer System (ProSEDS)

NASA Technical Reports Server (NTRS)

Lorenzini, Enrico C.; Cosmo, Mario L.; Estes, Robert D.; Sanmartin, Juan; Pelaez, Jesus; Ruiz, Manuel

2003-01-01

This Final Report covers the following main topics: 1) Brief Description of ProSEDS; 2) Mission Analysis; 3) Dynamics Reference Mission; 4) Dynamics Stability; 5) Deployment Control; 6) Updated System Performance; 7) Updated Mission Analysis; 8) Updated Dynamics Reference Mission; 9) Updated Deployment Control Profiles and Simulations; 10) Updated Reference Mission; 11) Evaluation of Power Delivered by the Tether; 12) Deployment Control Profile Ref. #78 and Simulations; 13) Kalman Filters for Mission Estimation; 14) Analysis/Estimation of Deployment Flight Data; 15) Comparison of ED Tethers and Electrical Thrusters; 16) Dynamics Analysis for Mission Starting at a Lower Altitude; 17) Deployment Performance at a Lower Altitude; 18) Satellite Orbit after a Tether Cut; 19) Deployment with Shorter Dyneema Tether Length; 20) Interactive Software for ED Tethers.

Separate encoding of model-based and model-free valuations in the human brain.

PubMed

Beierholm, Ulrik R; Anen, Cedric; Quartz, Steven; Bossaerts, Peter

2011-10-01

Behavioral studies have long shown that humans solve problems in two ways, one intuitive and fast (System 1, model-free), and the other reflective and slow (System 2, model-based). The neurobiological basis of dual process problem solving remains unknown due to challenges of separating activation in concurrent systems. We present a novel neuroeconomic task that predicts distinct subjective valuation and updating signals corresponding to these two systems. We found two concurrent value signals in human prefrontal cortex: a System 1 model-free reinforcement signal and a System 2 model-based Bayesian signal. We also found a System 1 updating signal in striatal areas and a System 2 updating signal in lateral prefrontal cortex. Further, signals in prefrontal cortex preceded choices that are optimal according to either updating principle, while signals in anterior cingulate cortex and globus pallidus preceded deviations from optimal choice for reinforcement learning. These deviations tended to occur when uncertainty regarding optimal values was highest, suggesting that disagreement between dual systems is mediated by uncertainty rather than conflict, confirming recent theoretical proposals. Copyright © 2011 Elsevier Inc. All rights reserved.

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics.

PubMed

Gibson, Glenn R; Hutkins, Robert; Sanders, Mary Ellen; Prescott, Susan L; Reimer, Raylene A; Salminen, Seppo J; Scott, Karen; Stanton, Catherine; Swanson, Kelly S; Cani, Patrice D; Verbeke, Kristin; Reid, Gregor

2017-08-01

In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective microbiota-mediated mechanisms was retained. Beneficial health effects must be documented for a substance to be considered a prebiotic. The consensus definition applies also to prebiotics for use by animals, in which microbiota-focused strategies to maintain health and prevent disease is as relevant as for humans. Ultimately, the goal of this Consensus Statement is to engender appropriate use of the term 'prebiotic' by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category. To this end, we have reviewed several aspects of prebiotic science including its development, health benefits and legislation.

The RACE (Research and Development in Advanced Technologies for Europe) Program: A 1989 Update

DTIC Science & Technology

1989-12-15

Definition TV (HDTV) Expcrimcntal Usage . A......a.d..r Dist special 1081 - Broadband User Network Interface (BUNI)..................... 4 1082 ...develop man/machine which will provide a traffic analyzer and generator. interfaces that are consistent across a wide range of ap-plications. 1082 ... 1082 are to provide usage reference models for the different types of e Define IBC quality of service rquiremnts by usage design issue. It deals with

A Fully Conserved Minimal Adjustment Scheme with (T, S) Coherency for Stabilization of Hydrographic Profiles

DTIC Science & Technology

2012-12-01

positive definite approximation of the Hessian is updated according to the modified Broyden–Fletcher–Goldfarb– Shanno method (Powell 1978). 3. Data Evident...averaged observational hydrographic data . This method adjusts the temperature and salinity profiles fDTk,DSk,k5 1, 2, . . . ,Kg simultaneously and...in data assimilations since it does not simply reject profiles with static instability. This method edits the profiles with the inequality constraint

78 FR 26255 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Approval of Texas Low...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

...EPA is granting direct final approval of a revision to the Texas State Implementation Plan (SIP) concerning the Texas Low Emission Diesel fuel rules. The revisions clarify existing definitions and provisions, revise the approval procedures for alternative diesel fuel formulations, add new registration requirements, and update the rule to reflect the current program status because the rule is now fully implemented. This SIP revision meets statutory requirements.

78 FR 26301 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Approval of Texas Low...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

...EPA is proposing approval of a revision to the Texas State Implementation Plan (SIP) concerning the Texas Low Emission Diesel (TxLED) Fuel rules. The revisions clarify existing definitions and provisions, revise the approval procedures for alternative diesel fuel formulations, add new registration requirements, and update the rule to reflect the current program status because the rule is now fully implemented. This SIP revision meets statutory requirements.

New National Blood Pressure Guidelines Are More Rigorous, but OHS Is Here to Help | Poster

Cancer.gov

A task force led by physicians from the American College of Cardiology and the American Heart Association has released new blood pressure guidelines in order to help doctors and clinicians better treat hypertensive and prehypertensive individuals who may be at risk of heart disease. The update, which comes nearly 15 years after its predecessor, has significantly broadened the definition of hypertension and reclassified other blood pressure categories.

Toms, Coons, Mulattoes, Mammies, & Bucks: An Interpretive History of Blacks in American Films. New Expanded Edition.

ERIC Educational Resources Information Center

Bogle, Donald

This classic, definitive study of Black images in American movies has been completely revised and updated to include new chapters on the films of the 1970s and 1980s. This new version of the book reveals the way in which the image of Blacks in American movies has changed--and also the way in which it has remained the same. Following a preface to…

An Evaluation of Individual Empowerment and Self-Efficacy on Sexual Harrassment in the Work Environment

DTIC Science & Technology

1993-09-01

Air Force Regulation 30-2, which was updated in July 1992. Since the research is focused on Air Force personnel, the researchers have decided to use...Opportunity Commission ( EEOC ) guidance, some progress has been achieved in defining and characterizing harassment (Gruber, 1992:448; Englander, 1992:17; Van...evolution of sexual harassment through changing historical attitudes, definition refinement as a result of judicial and EEOC rulings, and relevant legal

RCRA, Superfund and EPCRA hotline training module. Introduction to: Applicable or relevant and appropriate requirements (updated February 1998)

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-06-01

Topics addressed include the following: Regulatory Summary (Role and Definition of Applicable or Relevant and Appropriate Requirements); Types of ARARs; Extent of ARARs: On-Site vs. Off-Site Management; Remedial vs. Removal Actions; To-Be-Considered Guidelines and Other Controls; ARAR Identification (ARAR Identification Process); Federal ARARs: RCRA, CAA, CWA, SDWA, TSCA; State and Local ARARs and ARAR Waivers; and Module Summary.

Evolving learning rules and emergence of cooperation in spatial prisoner's dilemma.

PubMed

Moyano, Luis G; Sánchez, Angel

2009-07-07

In the evolutionary Prisoner's dilemma (PD) game, agents play with each other and update their strategies in every generation according to some microscopic dynamical rule. In its spatial version, agents do not play with every other but, instead, interact only with their neighbours, thus mimicking the existing of a social or contact network that defines who interacts with whom. In this work, we explore evolutionary, spatial PD systems consisting of two types of agents, each with a certain update (reproduction, learning) rule. We investigate two different scenarios: in the first case, update rules remain fixed for the entire evolution of the system; in the second case, agents update both strategy and update rule in every generation. We show that in a well-mixed population the evolutionary outcome is always full defection. We subsequently focus on two-strategy competition with nearest-neighbour interactions on the contact network and synchronised update of strategies. Our results show that, for an important range of the parameters of the game, the final state of the system is largely different from that arising from the usual setup of a single, fixed dynamical rule. Furthermore, the results are also very different if update rules are fixed or evolve with the strategies. In these respect, we have studied representative update rules, finding that some of them may become extinct while others prevail. We describe the new and rich variety of final outcomes that arise from this co-evolutionary dynamics. We include examples of other neighbourhoods and asynchronous updating that confirm the robustness of our conclusions. Our results pave the way to an evolutionary rationale for modelling social interactions through game theory with a preferred set of update rules.

Formal Definitions of Unbounded Evolution and Innovation Reveal Universal Mechanisms for Open-Ended Evolution in Dynamical Systems.

PubMed

Adams, Alyssa; Zenil, Hector; Davies, Paul C W; Walker, Sara Imari

2017-04-20

Open-ended evolution (OEE) is relevant to a variety of biological, artificial and technological systems, but has been challenging to reproduce in silico. Most theoretical efforts focus on key aspects of open-ended evolution as it appears in biology. We recast the problem as a more general one in dynamical systems theory, providing simple criteria for open-ended evolution based on two hallmark features: unbounded evolution and innovation. We define unbounded evolution as patterns that are non-repeating within the expected Poincare recurrence time of an isolated system, and innovation as trajectories not observed in isolated systems. As a case study, we implement novel variants of cellular automata (CA) where the update rules are allowed to vary with time in three alternative ways. Each is capable of generating conditions for open-ended evolution, but vary in their ability to do so. We find that state-dependent dynamics, regarded as a hallmark of life, statistically out-performs other candidate mechanisms, and is the only mechanism to produce open-ended evolution in a scalable manner, essential to the notion of ongoing evolution. This analysis suggests a new framework for unifying mechanisms for generating OEE with features distinctive to life and its artifacts, with broad applicability to biological and artificial systems.

Self-learning Monte Carlo method and cumulative update in fermion systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Junwei; Shen, Huitao; Qi, Yang

2017-06-07

In this study, we develop the self-learning Monte Carlo (SLMC) method, a general-purpose numerical method recently introduced to simulate many-body systems, for studying interacting fermion systems. Our method uses a highly efficient update algorithm, which we design and dub “cumulative update”, to generate new candidate configurations in the Markov chain based on a self-learned bosonic effective model. From a general analysis and a numerical study of the double exchange model as an example, we find that the SLMC with cumulative update drastically reduces the computational cost of the simulation, while remaining statistically exact. Remarkably, its computational complexity is far lessmore » than the conventional algorithm with local updates.« less

42 CFR 484.225 - Annual update of the unadjusted national prospective 60-day episode payment rate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 5 2014-10-01 2014-10-01 false Annual update of the unadjusted national... SERVICES Prospective Payment System for Home Health Agencies § 484.225 Annual update of the unadjusted national prospective 60-day episode payment rate. (a) CMS updates the unadjusted national 60-day episode...

42 CFR 484.225 - Annual update of the unadjusted national prospective 60-day episode payment rate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 5 2012-10-01 2012-10-01 false Annual update of the unadjusted national... SERVICES Prospective Payment System for Home Health Agencies § 484.225 Annual update of the unadjusted national prospective 60-day episode payment rate. (a) CMS updates the unadjusted national 60-day episode...

42 CFR 484.225 - Annual update of the unadjusted national prospective 60-day episode payment rate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Annual update of the unadjusted national... SERVICES Prospective Payment System for Home Health Agencies § 484.225 Annual update of the unadjusted national prospective 60-day episode payment rate. (a) CMS updates the unadjusted national 60-day episode...

42 CFR 484.225 - Annual update of the unadjusted national prospective 60-day episode payment rate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 5 2013-10-01 2013-10-01 false Annual update of the unadjusted national... SERVICES Prospective Payment System for Home Health Agencies § 484.225 Annual update of the unadjusted national prospective 60-day episode payment rate. (a) CMS updates the unadjusted national 60-day episode...

42 CFR 484.225 - Annual update of the unadjusted national prospective 60-day episode payment rate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Annual update of the unadjusted national... SERVICES Prospective Payment System for Home Health Agencies § 484.225 Annual update of the unadjusted national prospective 60-day episode payment rate. (a) CMS updates the unadjusted national 60-day episode...

Risky business: Preventing skin breakdown in children with spina bifida.

PubMed

Ekmark, Elaine McGarr

2009-01-01

The purpose of this article is to provide an overview of skin issues in children with spina bifida. Included in the discussion below is a review of the etiology of pressure ulcers and the updated 2007 pressure ulcer definition and pressure ulcer staging system as defined by the National Pressure Ulcer Advisory Panel (NPUAP). Pediatric risk factors for skin breakdown are presented including risk factors unique to children with spina bifida. Pediatric pressure ulcer risk assessment scales are described. The 5 Million Lives Kids' Campaign which has a focus on preventing hospital-acquired pressure ulcers in children is also reviewed along with evidence based prevention strategies. The key to preventing skin breakdown and pressure ulcers in children with spina bifida is early identification of the child's individual risk factors so that a prevention protocol can be implemented in all settings: hospital, home and the community. Options for wound management, dressing selection and pain management are included.

Development and Operations of the Astrophysics Data System

NASA Technical Reports Server (NTRS)

Murray, Stephen S.; Oliversen, Ronald (Technical Monitor)

2003-01-01

SAO TASKS ACCOMPLISHED: Abstract Service: (1) Continued regular updates of abstracts in the databases, both at SAO and at all mirror sites; (2) Established a new naming convention of QB books in preparation for adding physics books from Hollis or Library of Congress; (3) Modified handling of object tag so as not to interfere with XHTML definition; (4) Worked on moving 'what's new' announcements to a majordomo email list so as not to interfere with divisional mail handling; (5) Implemented and tested new first author feature following suggestions from users at the AAS meeting; (6) Added SSRv entries back to volume 1 in preparation for scanning of the journal; (7) Assisted in the re-configuration of the ADS mirror site at the CDS and sent a new set of tapes containing article data to allow re-creation of the ADS article data lost during the move; (8) Created scripts to automatically download Astrobiology.

Method of evaluating, expanding, and collapsing connectivity regions within dynamic systems

DOEpatents

Bailey, David A [Schenectady, NY

2004-11-16

An automated process defines and maintains connectivity regions within a dynamic network. The automated process requires an initial input of a network component around which a connectivity region will be defined. The process automatically and autonomously generates a region around the initial input, stores the region's definition, and monitors the network for a change. Upon detecting a change in the network, the effect is evaluated, and if necessary the regions are adjusted and redefined to accommodate the change. Only those regions of the network affected by the change will be updated. This process eliminates the need for an operator to manually evaluate connectivity regions within a network. Since the automated process maintains the network, the reliance on an operator is minimized; thus, reducing the potential for operator error. This combination of region maintenance and reduced operator reliance, results in a reduction of overall error.

Update on cryotherapy for localized prostate cancer.

PubMed

Ritch, Chad R; Katz, Aaron E

2009-05-01

Stage migration has led to an increased incidence of localized and low-risk prostate cancer. Intermediate-term data are emerging on the efficacy of cryotherapy, but direct comparison to other therapeutic modalities is difficult as the parameters for recurrence are not well defined. Studies using the American Society for Therapeutic Radiation and Oncology and the Phoenix (nadir plus 2) criteria for biochemical recurrence show that primary cryotherapy appears to be comparable for low-risk prostate cancer as other treatment modalities. In addition, health-related quality-of-life measures have improved with the most recent third-generation systems demonstrating low incontinence and urethrorectal fistula rates. Erectile dysfunction is high with whole gland ablation, but focal therapy may reduce these rates while still ablating unilateral cancerous tissue. Prostate cryotherapy for localized prostate cancer is an evolving but viable therapeutic option. Long-term data are still needed to establish a definitive role for cryosurgery in prostate cancer treatment.

Thyroid storm: an updated review.

PubMed

Chiha, Maguy; Samarasinghe, Shanika; Kabaker, Adam S

2015-03-01

Thyroid storm, an endocrine emergency first described in 1926, remains a diagnostic and therapeutic challenge. No laboratory abnormalities are specific to thyroid storm, and the available scoring system is based on the clinical criteria. The exact mechanisms underlying the development of thyroid storm from uncomplicated hyperthyroidism are not well understood. A heightened response to thyroid hormone is often incriminated along with increased or abrupt availability of free hormones. Patients exhibit exaggerated signs and symptoms of hyperthyroidism and varying degrees of organ decompensation. Treatment should be initiated promptly targeting all steps of thyroid hormone formation, release, and action. Patients who fail medical therapy should be treated with therapeutic plasma exchange or thyroidectomy. The mortality of thyroid storm is currently reported at 10%. Patients who have survived thyroid storm should receive definite therapy for their underlying hyperthyroidism to avoid any recurrence of this potentially fatal condition. © The Author(s) 2013.

Endoscopic Management of Peri-Pancreatic Fluid Collections.

PubMed

Yip, Hon Chi; Teoh, Anthony Yuen Bun

2017-09-15

In the past decade, there has been a progressive paradigm shift in the management of peri-pancreatic fluid collections after acute pancreatitis. Refinements in the definitions of fluid collections from the updated Atlanta classification have enabled better communication amongst physicians in an effort to formulate optimal treatments. Endoscopic ultrasound (EUS)-guided drainage of pancreatic pseudocysts has emerged as the procedure of choice over surgical cystogastrostomy. The approach provides similar success rates with low complications and better quality of life compared with surgery. However, an endoscopic "step up" approach in the management of pancreatic walled-off necrosis has also been advocated. Both endoscopic and percutaneous drainage routes may be used depending on the anatomical location of the collections. New-generation large diameter EUS-specific stent systems have also recently been described. The device allows precise and effective drainage of the collections and permits endoscopic necrosectomy through the stents.

An Update on Hidradenitis Suppurativa (Part I): Epidemiology, Clinical Aspects, and Definition of Disease Severity.

PubMed

Martorell, A; García-Martínez, F J; Jiménez-Gallo, D; Pascual, J C; Pereyra-Rodriguez, J; Salgado, L; Vilarrasa, E

2015-11-01

Hidradenitis suppurativa is a chronic inflammatory disorder that has attracted increasing attention in recent years due to underestimations of prevalence and the considerable impact of the condition on interpersonal relationships, physical appearance, self-esteem, and body image. Although hidradenitis suppurative has a significant psychological impact on patients and can even cause physical limitations when thick scarring results in limb mobility limitation, until very recently little evidence was available relating to its epidemiology, etiology, or pathogenesis. In this review, we highlight the latest advances in our understanding of the epidemiological and clinical aspects of hidradenitis suppurativa. We will also look at the different classification systems for hidradenitis suppurativa and discuss the emergence of skin ultrasound as a promising technique for monitoring the course of this chronic inflammatory disease. Copyright © 2015 Elsevier España, S.L.U. and AEDV. All rights reserved.

Update on the medical treatment of juvenile idiopathic arthritis.

PubMed

Hashkes, Philip J; Laxer, Ronald M

2006-12-01

Many exciting developments in the treatment of juvenile idiopathic arthritis (JIA) have emerged recently, including new tools to assess the results of clinical trials (eg, the definition of remission and a radiologic scoring tool). New controlled studies examined the equivalence of meloxicam to naproxen, the efficacy of leflunomide but the superiority of methotrexate, and the use of infliximab in polyarthritis JIA. Initial studies have shown the potential of anti-interleukin (IL)-1 and anti-IL-6 receptor antibody therapy for systemic JIA. Corticosteroid-sparing medications including the use of "biologic modifiers" for JIA-associated uveitis have been described. Evidence-based guidelines for the main subtypes of JIA have been published. However, good evidence on the treatment of several disease subtypes is still lacking. Studies of new medications and the use of combination therapy, including aggressive induction therapy early in the disease course, are necessary to continue improving the outcome of JIA patients.

JSC almanac

NASA Technical Reports Server (NTRS)

1993-01-01

During America's space shuttle flights, press and public attention focuses on the Johnson Space Center in Houston. The press and public often put questions to JSC technical and management staff. This fourth JSC Almanac supplies answers for many such questions, and provide an informational resource for speeches to general interest groups. This Almanac is not necessarily comprehensive or definitive. It is not intended as a statement of JSC or NASA policy. However, it does provide a much needed compilation of information from diverse sources. These sources are given as references, permitting the reader to obtain additional information as required. While every effort has been made to ensure accuracy and to reconcile statistics, users requiring the most up-to-date and accurate information should contact the office supplying the information at issue. The Almanac is updated periodically as needed. The following offices were responsible for supplying material for this update.

Pseudomonas aeruginosa essentials: an update on investigation of essential genes.

PubMed

Juhas, Mario

2015-11-01

Pseudomonas aeruginosa is the leading cause of nosocomial infections, particularly in immunocompromised, cancer, burn and cystic fibrosis patients. Development of novel antimicrobials against P. aeruginosa is therefore of the highest importance. Although the first reports on P. aeruginosa essential genes date back to the early 2000s, a number of more sensitive genomic approaches have been used recently to better define essential genes in this organism. These analyses highlight the evolution of the definition of an 'essential' gene from the traditional to the context-dependent. Essential genes, particularly those indispensable under the clinically relevant conditions, are considered to be promising targets of novel antibiotics against P. aeruginosa. This review provides an update on the investigation of P. aeruginosa essential genes. Special focus is on recently identified P. aeruginosa essential genes and their exploitation for the development of antimicrobials.

Wind turbines and health: An examination of a proposed case definition.

PubMed

McCunney, Robert J; Morfeld, Peter; Colby, W David; Mundt, Kenneth A

2015-01-01

Renewable energy demands have increased the need for new wind farms. In turn, concerns have been raised about potential adverse health effects on nearby residents. A case definition has been proposed to diagnose "Adverse Health Effects in the Environs of Industrial Wind Turbines" (AHE/IWT); initially in 2011 and then with an update in 2014. The authors invited commentary and in turn, we assessed its scientific merits by quantitatively evaluating its proposed application. We used binomial coefficients to quantitatively assess the potential of obtaining a diagnosis of AHE/IWT. We also reviewed the methodology and process of the development of the case definition by contrasting it with guidelines on case definition criteria of the USA Institute of Medicine. The case definition allows at least 3,264 and up to 400,000 possibilities for meeting second- and third-order criteria, once the limited first-order criteria are met. IOM guidelines for clinical case definitions were not followed. The case definition has virtually no specificity and lacks scientific support from peer-reviewed literature. If applied as proposed, its application will lead to substantial potential for false-positive assessments and missed diagnoses. Virtually any new illness that develops or any prevalent illness that worsens after the installation of wind turbines within 10 km of a residence could be considered AHE/IWT if the patient feels better away from home. The use of this case definition in the absence of a thorough medical evaluation with appropriate diagnostic studies poses risks to patients in that treatable disorders would be overlooked. The case definition has significant potential to mislead patients and its use cannot be recommended for application in any health-care or decision-making setting.

Wind turbines and health: An examination of a proposed case definition

PubMed Central

McCunney, Robert J.; Morfeld, Peter; Colby, W. David; Mundt, Kenneth A.

2015-01-01

Renewable energy demands have increased the need for new wind farms. In turn, concerns have been raised about potential adverse health effects on nearby residents. A case definition has been proposed to diagnose “Adverse Health Effects in the Environs of Industrial Wind Turbines” (AHE/IWT); initially in 2011 and then with an update in 2014. The authors invited commentary and in turn, we assessed its scientific merits by quantitatively evaluating its proposed application. We used binomial coefficients to quantitatively assess the potential of obtaining a diagnosis of AHE/IWT. We also reviewed the methodology and process of the development of the case definition by contrasting it with guidelines on case definition criteria of the USA Institute of Medicine. The case definition allows at least 3,264 and up to 400,000 possibilities for meeting second- and third-order criteria, once the limited first-order criteria are met. IOM guidelines for clinical case definitions were not followed. The case definition has virtually no specificity and lacks scientific support from peer-reviewed literature. If applied as proposed, its application will lead to substantial potential for false-positive assessments and missed diagnoses. Virtually any new illness that develops or any prevalent illness that worsens after the installation of wind turbines within 10 km of a residence could be considered AHE/IWT if the patient feels better away from home. The use of this case definition in the absence of a thorough medical evaluation with appropriate diagnostic studies poses risks to patients in that treatable disorders would be overlooked. The case definition has significant potential to mislead patients and its use cannot be recommended for application in any health-care or decision-making setting. PMID:26168947

Intelligent Transportation Systems in the National Parks System and Other Federal Public Lands - 2011 Update.

DOT National Transportation Integrated Search

2011-09-30

The Intelligent Transportation Systems in Federal Public Lands report details the state of ITS deployment across all federal land management agencies (FLMAs) in 2011, updating a Volpe Center report completed in 2005. An assessment of the types ...

Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes

PubMed Central

Makris, Konstantinos; Spanou, Loukia

2016-01-01

Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the outcome in a significant number of hospitalised patients. Recent advances in clinical and basic research will help with a more accurate definition of this syndrome and in the elucidation of its pathogenesis. With this knowledge we will be able to conduct more accurate epidemiologic studies in an effort to gain a better understanding of the impact of this syndrome. AKI is a syndrome that rarely has a sole and distinct pathophysiology. Recent evidence, in both basic science and clinical research, is beginning to change our view for AKI from a single organ failure syndrome to a syndrome where the kidney plays an active role in the progress of multi-organ dysfunction. Accurate and prompt recognition of AKI and better understanding of the pathophysiologic mechanisms underlying the various clinical phenotypes are of great importance to research for effective therapeutic interventions. In this review we provide the most recent updates in the definition, epidemiology and pathophysiology of AKI. PMID:28303073

NASA Thesaurus. Volumes 1 and 2; Hierarchical Listing with Definitions; Rotated Term Display

NASA Technical Reports Server (NTRS)

2012-01-01

The NASA Thesaurus contains the authorized subject terms by which the documents in the NASA STI Databases are indexed and retrieved. The scope of this controlled vocabulary includes not only aerospace engineering, but all supporting areas of engineering and physics, the natural space sciences (astronomy, astrophysics, planetary science), Earth sciences, and to some extent, the biological sciences. Volume 1 - Hierarchical Listing With Definitions contains over 18,400 subject terms, 4,300 definitions, and more than 4,500 USE cross references. The Hierarchical Listing presents full hierarchical structure for each term along with 'related term' lists, and can serve as an orthographic authority. Volume 2 - Rotated Term Display is a ready-reference tool which provides over 52,700 additional 'access points' to the thesaurus terminology. It contains the postable and nonpostable terms found in the Hierarchical Listing arranged in a KWIC (key-word-in-context) index. This CD-ROM version of the NASA Thesaurus is in PDF format and is updated to the current year of purchase.

Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes.

PubMed

Makris, Konstantinos; Spanou, Loukia

2016-05-01

Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the outcome in a significant number of hospitalised patients. Recent advances in clinical and basic research will help with a more accurate definition of this syndrome and in the elucidation of its pathogenesis. With this knowledge we will be able to conduct more accurate epidemiologic studies in an effort to gain a better understanding of the impact of this syndrome. AKI is a syndrome that rarely has a sole and distinct pathophysiology. Recent evidence, in both basic science and clinical research, is beginning to change our view for AKI from a single organ failure syndrome to a syndrome where the kidney plays an active role in the progress of multi-organ dysfunction. Accurate and prompt recognition of AKI and better understanding of the pathophysiologic mechanisms underlying the various clinical phenotypes are of great importance to research for effective therapeutic interventions. In this review we provide the most recent updates in the definition, epidemiology and pathophysiology of AKI.

Guidance system operations plan for manned cm earth orbital and lunar missions using program Colossus 3. Section 2: Data links

NASA Technical Reports Server (NTRS)

Hamilton, M. H.

1971-01-01

The data links for use with the guidance system operations plan for manned command module earth orbital and lunar missions using program Colossus 3 are presented. The subjects discussed are: (1) digital uplink to CMC, (2) command module contiguous block update, (3) CMC retrofire external data update, (4) CMC digital downlink, and (5) CMC entry update.

NASA Update for Unidata Stratcomm

NASA Technical Reports Server (NTRS)

Lynnes, Chris

2017-01-01

The NASA representative to the Unidata Strategic Committee presented a semiannual update on NASAs work with and use of Unidata technologies. The talk updated Unidata on the program of cloud computing prototypes underway for the Earth Observing System Data and Information System (EOSDIS). Also discussed was a trade study on the use of the Open source Project for a Network Data Access Protocol (OPeNDAP) with Web Object Storage in the cloud.

On Mario Bunge's Definition of System and System Boundary

ERIC Educational Resources Information Center

Cavallo, Andrew M.

2012-01-01

In this short paper we discuss Mario Bunge's definition of system boundary. It is quickly discovered that Bunge's definition of system and system boundary are both deficient. We thus propose new definitions, which (hopefully) improve the situation. Our definition of system boundary works off the same intuition behind Bunge's.

Evolving the Living With a Star Data System Definition

NASA Astrophysics Data System (ADS)

Otranto, J.; Dijoseph, M.; Worrall, W.

2003-04-01

NASA’s Living With a Star (LWS) Program is a space weather-focused and applications-driven research program. The LWS Program is soliciting input from the solar, space physics, space weather, and climate science communities to develop a system that enables access to science data associated with these disciplines, and advances the development of discipline and interdisciplinary findings. The LWS Program will implement a data system that builds upon the existing and planned data capture, processing, and storage components put in place by individual spacecraft missions and also inter-project data management systems, such as active archives, deep archives, and multi-mission repositories. It is technically feasible for the LWS Program to integrate data from a broad set of resources, assuming they are either publicly accessible or access is permitted by the system’s administrators. The LWS Program data system will work in coordination with spacecraft mission data systems and science data repositories, integrating them into a common data representation. This common representation relies on a robust metadata definition that provides journalistic and technical data descriptions, plus linkages to supporting data products and tools. The LWS Program intends to become an enabling resource to PIs, interdisciplinary scientists, researchers, and students facilitating both access to a broad collection of science data, as well as the necessary supporting components to understand and make productive use of the data. For the LWS Program to represent science data that is physically distributed across various ground system elements, information about the data products stored on each system is collected through a series of LWS-created active agents. These active agents are customized to interface or interact with each one of these data systems, collect information, and forward updates to a single LWS-developed metadata broker. This broker, in turn, updates a centralized repository of LWS-specific metadata. A populated LWS metadata database is a single point-of-contact that can serve all users (the science community) with a “one-stop-shop” for data access. While data may not be physically stored in an LWS-specific repository, the LWS system enables data access from wherever the data are stored. Moreover, LWS provides the user access to information for understanding the data source, format, and calibration, enables access to ancillary and correlative data products, provides links to processing tools and models associated with the data, and any corresponding findings. The LWS may also support an active archive for solar, space physics, space weather, and climate data when these data would otherwise be discarded or archived off-line. This archive could potentially serve as a backup facility for LWS missions. This plan is developed based upon input already received from the science community; the architecture is based on system developed to date that have worked well on a smaller scale. The LWS Program continues to seek constructive input from the science community, examples of both successes and failures in dealing with science data systems, and insights regarding the obstacles between the current state-of-the-practice and this vision for the LWS Program data system.

78 FR 49479 - Updates to List of National System of Marine Protected Areas MPAs

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... System of Marine Protected Areas MPAs AGENCY: National Marine Protected Areas Center (MPA Center), Office... Administration (NOAA), Department of Commerce (DOC). ACTION: Notice of updates to the list of National System of Marine Protected Areas (MPAs). SUMMARY: The National System of Marine Protected Areas (MPAs) provides a...

48 CFR 52.209-8 - Updates of Information Regarding Responsibility Matters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Updates of Information... Information System (FAPIIS) on a semi-annual basis, throughout the life of the contract, by entering the... Contractor's record in the system. Public requests for system information will be handled under Freedom of...

Tennessee long-range transportation plan : aviation system plan update

DOT National Transportation Integrated Search

2005-01-01

This plan update is streamlined in nature and will only consider the ttates six commercial service airports and 14 regional airports. The tasks completed for this update included an inventory of facilities, aviation industry review, review and upd...

Mobility 2025 update : the metropolitan transportation plan : executive summary

DOT National Transportation Integrated Search

2009-01-01

Mobility 2025 Update: The Metropolitan Transportation Plan website. Mobility 2025 Update is the defining vision for transportation systems and services in the Dallas-Fort Worth metropolitan area. Serving as a guide for the expenditure of state and fe...

Cleanups In My Community (CIMC) - Brownfields Properties, National Layer

EPA Pesticide Factsheets

This data layer provides access to Brownfields Properties as part of the CIMC web service, although the data are generally more broadly applicable. Brownfields are real properties, the expansion, redevelopment, or reuse of which may be complicated by the presence or potential presence of a hazardous substance, pollutant, or contaminant. Cleaning up and reinvesting in these properties takes development pressures off of undeveloped, open land, and both improves and protects the environment. CIMC provides information on Brownfields properties for which information is reported back to EPA, as well as areas served by Brownfields grants programs. Brownfields properties may be mapped or listed, and property profiles can be accessed from either maps or lists. There are many properties that meet the definition of a brownfield but are not funded by our program. They may be funded by states, localities, private or non-profit entities. The Brownfields data are reported by grant recipients via the ACRES database and updated and stored in Envirofacts monthly. For more information on the data updates to Envirofacts, please visit the Envirofacts Data Update page.For more information on the data provided through this webservice, please see the processing steps below, and see more information here: https://www.epa.gov/cleanups/cimc-about-data#brownfieldsp.The CIMC web service was initially published in 2013, but the data are updated on the 18th of each month. The full schedule f

Updated optical read/write memory system components

NASA Technical Reports Server (NTRS)

1973-01-01

The fabrication of an updated block data composer and holographic storage array for a breadboard holographic read/write memory system is described. System considerations such as transform optics and controlled aberration lens design are described along with the block data composer, photoplastic recording materials, and material development.

76 FR 35483 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... May 12, 2009, revisions, and will update the retention period from 6 months to 12 months for online...; retrievability; safeguards; retention and disposal; system manager(s) and address; notification procedure; and..., and planning. The other changes outlined update retention periods, administrative changes, and system...

META-GLARE: A meta-system for defining your own computer interpretable guideline system-Architecture and acquisition.

PubMed

Bottrighi, Alessio; Terenziani, Paolo

2016-09-01

Several different computer-assisted management systems of computer interpretable guidelines (CIGs) have been developed by the Artificial Intelligence in Medicine community. Each CIG system is characterized by a specific formalism to represent CIGs, and usually provides a manager to acquire, consult and execute them. Though there are several commonalities between most formalisms in the literature, each formalism has its own peculiarities. The goal of our work is to provide a flexible support to the extension or definition of CIGs formalisms, and of their acquisition and execution engines. Instead of defining "yet another CIG formalism and its manager", we propose META-GLARE (META Guideline Acquisition, Representation, and Execution), a "meta"-system to define new CIG systems. In this paper, META-GLARE, a meta-system to define new CIG systems, is presented. We try to capture the commonalities among current CIG approaches, by providing (i) a general manager for the acquisition, consultation and execution of hierarchical graphs (representing the control flow of actions in CIGs), parameterized over the types of nodes and of arcs constituting it, and (ii) a library of different elementary components of guidelines nodes (actions) and arcs, in which each type definition involves the specification of how objects of this type can be acquired, consulted and executed. We provide generality and flexibility, by allowing free aggregations of such elementary components to define new primitive node and arc types. We have drawn several experiments, in which we have used META-GLARE to build a CIG system (Experiment 1 in Section 8), or to extend it (Experiments 2 and 3). Such experiments show that META-GLARE provides a useful and easy-to-use support to such tasks. For instance, re-building the Guideline Acquisition, Representation, and Execution (GLARE) system using META-GLARE required less than one day (Experiment 1). META-GLARE is a meta-system for CIGs supporting fast prototyping. Since META-GLARE provides acquisition and execution engines that are parametric over the specific CIG formalism, it supports easy update and construction of CIG systems. Copyright © 2016 Elsevier B.V. All rights reserved.

Working paper : national costs of the metropolitan ITS infrastructure : updated with 2004 deployment data

DOT National Transportation Integrated Search

The purpose of this report, "Working Paper National Costs of the Metropolitan ITS infrastructure: Updated with 2004 Deployment Data," is to update the estimates of the costs remaining to deploy Intelligent Transportation Systems (ITS) infrastructure ...

Transforming transportation through connectivity : ITS strategic research plan, 2010-2014 progress update, 2012

DOT National Transportation Integrated Search

2012-10-31

This document updates the Intelligent Transportation Systems Strategic Research Plan, 20102014, a focused research agenda whose goal is to deliver the foundational systems, technologies, and applications that provide transportation connectivity to...

DigitalGlobe(TM) Incorporated Corporate and System Update

NASA Technical Reports Server (NTRS)

Thomassie, Brett

2007-01-01

This viewgraph presentation describes a system update of Quickbird, the world's highest resolution commercial imaging satellite, operated by DigitalGlobe (TM) Incorporated. A satellite comparison of Quickbird, WorldView-60, and WorldView-110 is also presented.

Eleventh Annual Report of Accomplishments Under the Airport Improvement Program

DTIC Science & Technology

1992-01-01

552,860 INSTALL SECURITY SYSTEM PORTLAND INTERNATIONAL JETPORT (PRIMARY) 25 $255, 195 CONSTRUCT ACCESS ROAD PRESQUE ISLE 09 $988,548 CONSTRUCT AIRCRAFT...TAXIWAYS; INSTALL VISUAL APPROACH AIDS PENNSYLVANIA COMMONWEALTH OF PENNSYLVANIA S7 $89,050 CONDUCT STATE SYSTEM PLAN UPDATE (SYSTEM PLAN) DELAWARE...VALLEY REGION RA $195,030 CONDUCT STATE SYSTEM PLAN UPDATE (SYSTEM PLAN) SOUTHWESTERN PENNSYLVANIA REGION RA $310,950 CONDUCT REGIONAL SYSTEM PLAN

40 CFR 1065.309 - Continuous gas analyzer system-response and updating-recording verification-for gas analyzers...

Code of Federal Regulations, 2010 CFR

2010-07-01

... change the system response. (b) Measurement principles. This procedure verifies that the updating and... gas detectors used to generate a continuously combined/compensated concentration measurement signal... verifies that the measurement system meets a minimum response time. For this procedure, ensure that all...

78 FR 79457 - Privacy Act of 1974; Notice of an Updated System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

...] Privacy Act of 1974; Notice of an Updated System of Records AGENCY: General Services Administration. ACTION: Notice. SUMMARY: The U.S. General Services Administration (GSA) reviewed its Privacy Act systems... legal or regulatory authority. DATES: Effective date: January 29, 2014. FOR FURTHER INFORMATION CONTACT...

IMS Version 3 Student Data Base Maintenance Program.

ERIC Educational Resources Information Center

Brown, John R.

Computer routines that update the Instructional Management System (IMS) Version 3 student data base which supports the Southwest Regional Laboratory's (SWRL) student monitoring system are described. Written in IBM System 360 FORTRAN IV, the program updates the data base by adding, changing and deleting records, as well as adding and deleting…

Program Description: EDIT Program and Vendor Master Update, SWRL Financial System.

ERIC Educational Resources Information Center

Ikeda, Masumi

Computer routines to edit input data for the Southwest Regional Laboratory's (SWRL) Financial System are described. The program is responsible for validating input records, generating records for further system processing, and updating the Vendor Master File--a file containing the information necessary to support the accounts payable and…

Hybrid diversity method utilizing adaptive diversity function for recovering unknown aberrations in an optical system

NASA Technical Reports Server (NTRS)

Dean, Bruce H. (Inventor)

2009-01-01

A method of recovering unknown aberrations in an optical system includes collecting intensity data produced by the optical system, generating an initial estimate of a phase of the optical system, iteratively performing a phase retrieval on the intensity data to generate a phase estimate using an initial diversity function corresponding to the intensity data, generating a phase map from the phase retrieval phase estimate, decomposing the phase map to generate a decomposition vector, generating an updated diversity function by combining the initial diversity function with the decomposition vector, generating an updated estimate of the phase of the optical system by removing the initial diversity function from the phase map. The method may further include repeating the process beginning with iteratively performing a phase retrieval on the intensity data using the updated estimate of the phase of the optical system in place of the initial estimate of the phase of the optical system, and using the updated diversity function in place of the initial diversity function, until a predetermined convergence is achieved.

Recent Updates of A Multi-Phase Transport (AMPT) Model

NASA Astrophysics Data System (ADS)

Lin, Zi-Wei

2008-10-01

We will present recent updates to the AMPT model, a Monte Carlo transport model for high energy heavy ion collisions, since its first public release in 2004 and the corresponding detailed descriptions in Phys. Rev. C 72, 064901 (2005). The updates often result from user requests. Some of these updates expand the physics processes or descriptions in the model, while some updates improve the usability of the model such as providing the initial parton distributions or help avoid crashes on some operating systems. We will also explain how the AMPT model is being maintained and updated.

Timing considerations of Helmet Mounted Display performance

NASA Technical Reports Server (NTRS)

Tharp, Gregory; Liu, Andrew; French, Lloyd; Lai, Steve; Stark, Lawrence

1992-01-01

The Helmet Mounted Display (HMD) system developed in our lab should be a useful teleoperator systems display if it increases operator performance of the desired task; it can, however, introduce degradation in performance due to display update rate constraints and communication delays. Display update rates are slowed by communication bandwidth and/or computational power limitations. We used simulated 3D tracking and pick-and-place tasks to characterize performance levels for a range of update rates. Initial experiments with 3D tracking indicate that performance levels plateau at an update rate between 10 and 20 Hz. We have found that using the HMD with delay decreases performance as delay increases.

Computer architecture for efficient algorithmic executions in real-time systems: New technology for avionics systems and advanced space vehicles

NASA Technical Reports Server (NTRS)

Carroll, Chester C.; Youngblood, John N.; Saha, Aindam

1987-01-01

Improvements and advances in the development of computer architecture now provide innovative technology for the recasting of traditional sequential solutions into high-performance, low-cost, parallel system to increase system performance. Research conducted in development of specialized computer architecture for the algorithmic execution of an avionics system, guidance and control problem in real time is described. A comprehensive treatment of both the hardware and software structures of a customized computer which performs real-time computation of guidance commands with updated estimates of target motion and time-to-go is presented. An optimal, real-time allocation algorithm was developed which maps the algorithmic tasks onto the processing elements. This allocation is based on the critical path analysis. The final stage is the design and development of the hardware structures suitable for the efficient execution of the allocated task graph. The processing element is designed for rapid execution of the allocated tasks. Fault tolerance is a key feature of the overall architecture. Parallel numerical integration techniques, tasks definitions, and allocation algorithms are discussed. The parallel implementation is analytically verified and the experimental results are presented. The design of the data-driven computer architecture, customized for the execution of the particular algorithm, is discussed.

2013 White Book, Pacific Northwest Loads and Resources Study (summary)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The 2013 Pacific Northwest Loads and Resources Study (2013 White Book) is BPA's latest projection of the Pacific Northwest regional retail loads, contract obligations, contract purchases, and resource capabilities. The 2013 White Book is a snapshot of conditions as of October 1, 2013, documenting the loads and resources for the Federal system and region for the 10-year study period OY 2014 through 2023. The White Book contains projections of regional and Federal system load and resource capabilities, along with relevant definitions and explanations. The White Book also contains information obtained from formalized resource planning reports and data submittals including thosemore » from individual utilities, the Northwest Power and Conservation Council (Council), and the Pacific Northwest Utilities Conference Committee (PNUCC). Starting with the 2012 White Book, BPA changed the annual production schedule for future White Books. BPA is scheduled to publish a complete White Book, which includes a Federal System Needs Assessment analysis, every other year (even years). In the odd-numbered years, BPA will publish a biennial summary update (Supplement) that only contains major changes to the Federal System and Regional System analyses that have occurred since the last White Book. http://www.bpa.gov/power/pgp/whitebook/2013/index.shtml.« less

Computer architecture for efficient algorithmic executions in real-time systems: new technology for avionics systems and advanced space vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carroll, C.C.; Youngblood, J.N.; Saha, A.

1987-12-01

Improvements and advances in the development of computer architecture now provide innovative technology for the recasting of traditional sequential solutions into high-performance, low-cost, parallel system to increase system performance. Research conducted in development of specialized computer architecture for the algorithmic execution of an avionics system, guidance and control problem in real time is described. A comprehensive treatment of both the hardware and software structures of a customized computer which performs real-time computation of guidance commands with updated estimates of target motion and time-to-go is presented. An optimal, real-time allocation algorithm was developed which maps the algorithmic tasks onto the processingmore » elements. This allocation is based on the critical path analysis. The final stage is the design and development of the hardware structures suitable for the efficient execution of the allocated task graph. The processing element is designed for rapid execution of the allocated tasks. Fault tolerance is a key feature of the overall architecture. Parallel numerical integration techniques, tasks definitions, and allocation algorithms are discussed. The parallel implementation is analytically verified and the experimental results are presented. The design of the data-driven computer architecture, customized for the execution of the particular algorithm, is discussed.« less

Working paper : national costs of the metropolitan ITS infrastructure : updated with 2005 deployment data

DOT National Transportation Integrated Search

2006-07-01

The purpose of this report, "Working Paper National Costs of the Metropolitan ITS Infrastructure: Updated with 2005 Deployment Data," is to update the estimates of the costs remaining to fully deploy Intelligent Transportation Systems (ITS) infrastru...

Technology for the future - Long range planning for space technology development

NASA Technical Reports Server (NTRS)

Collier, Lisa D.; Breckenridge, Roger A.; Llewellyn, Charles P.

1992-01-01

NASA's Office of Aeronautics and Space Technology (OAST) has begun the definition of an Integrated Technology Plan for the civilian space program which guides long-term technology development for space platforms, in light of continuing marker research and other planning data. OAST has conferred particular responsibility for future candidate space mission evaluations and platform performance requirement projections to NASA-Langley. An implementation plan is devised which is amenable to periodic space-platform technology updates.

Joint Long-Range Energy Study for Greater Fairbanks Military Complex

DTIC Science & Technology

2005-02-01

be viewed as a two - stage processor of a fuel or feedstock. The feedstock is first gasified using high-temperature plasma heating sys- tems at...Coal-Fired Boilers with New Circulating Fluidized- Bed Boilers (CFBs). EAFB anticipates replacing two current boilers with two new boilers. This...definition to support DD Form 1391 budget level cost estimates for new coal-fired CHPPs at FWA and EAFB and for two new coal-fired CFBs at EAFB • update

World Health Organization Group I Pulmonary Hypertension: Epidemiology and Pathophysiology.

PubMed

Prins, Kurt W; Thenappan, Thenappan

2016-08-01

Pulmonary arterial hypertension (PAH) is a debilitating disease characterized by pathologic remodeling of the resistance pulmonary arteries, ultimately leading to right ventricular (RV) failure and death. In this article we discuss the definition of PAH, the initial epidemiology based on the National Institutes of Health Registry, and the updated epidemiology gleaned from contemporary registries, pathogenesis of pulmonary vascular dysfunction and proliferation, and RV failure in PAH. Copyright © 2016 Elsevier Inc. All rights reserved.

RCRA, superfund and EPCRA hotline training module. Introduction to: Boilers and industrial furnaces (40 cfr part 266, subpart h) updated July 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-07-01

The module summarizes the regulations affecting hazardous waste processes in boilers and industrial furnaces (BIFs). If defines boilers and industrial furnaces and describes the criteria associated with the definitions. It describes the requirements for processing hazardous waste in BIFs, including the distinctions between permitted and interim status units. It explains the requirements for the specially regulated BIFs and gives examples of each.

The multidisciplinary management of gastro-oesophageal junction tumours: European Society of Digestive Oncology (ESDO): Expert discussion and report from the 16th ESMO World Congress on Gastrointestinal Cancer, Barcelona.

PubMed

Van Laethem, J-L; Carneiro, F; Ducreux, M; Messman, H; Lordick, F; Ilson, D H; Allum, W H; Haustermans, K; Lepage, C; Matysiak-Budnik, T; Cats, A; Schmiegel, W; Cervantes, A; Van Cutsem, E; Rougier, Ph; Seufferlein, Th

2016-11-01

The management of GOJ cancers remains controversial and may vary between countries. Evidence-based attitudes and guidelines are not easy to elaborate since most of the trials and studies reported mixed cases of oesophageal (both adenocarcinoma and squamous cell tumours), GOJ and gastric cancers. The aim of this expert discussion and position paper is to elaborate practical recommendations that integrate evidence-reported literature and experience-based attitude covering all clinical aspects of GOJ cancer across different specialities and countries in Europe. Opinion leaders, selected on scientific merit were asked to answer to a prepared set of questions covering the approach of GOJ tumours from definition to therapeutic strategies. All answers were then discussed during a plenary session and reported here in providing a well-balanced reflection of both clinical expertise and updated evidence-based medicine. Definition, classification, diagnosis and staging of GOJ tumours were updated and debated. Therapeutic aspects including endoscopic therapy, surgical management, both multimodal curative and palliative management were also reviewed for proposing practical and consensual positions and recommendations whenever possible. GOJ tumours deserve specific attention,not only for uniformising clinical management across countries but also for performing specific clinical and translational research,mainly in the curative perioperative setting. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Update to a guide to standardized highway lighting pole hardware.

DOT National Transportation Integrated Search

2013-03-01

This report describes the development of an updated Online Guide to Luminaire Supports. The Guide is a web-based content : management system for luminaire support systems that allows full viewing, submission, management, and reporting services : to i...

Development of a landlside EWS based on rainfall thresholds for Tuscany Region, Italy

NASA Astrophysics Data System (ADS)

Rosi, Ascanio; Segoni, Samuele; Battistini, Alessandro; Rossi, Guglielmo; Catani, Filippo; Casagli, Nicola

2017-04-01

We present the set-up of a landslide EWS based on rainfall thresholds for the Tuscany region (central Italy), that shows a heterogeneous distribution of reliefs and precipitation. The work started with the definition of a single set of thresholds for the whole region, but it resulted unsuitable for EWS purposes, because of the heterogeneity of the Tuscan territory and non-repeatability of the analyses, that were affected by a high degree of subjectivity. To overcome this problem, the work started from the implementation of a software capable of objectively defining the rainfall thresholds, since some of the main issues of these thresholds are the subjectivity of the analysis and therefore their non-repeatability. This software, named MaCumBA, is largely automated and can analyze, in a short time, a high number of rainfall events to define several parameters of the threshold, such as the intensity (I) and the duration (D) of the rainfall event, the no-rain time gap (NRG: how many hours without rain are needed to consider two events as separated) and the equation describing the threshold. The possibility of quickly perform several analyses lead to the decision to divide the territory in 25 homogeneous areas (named alert zones, AZ), so as a single threshold for each AZ could be defined. For the definition of the thresholds two independent datasets (of joint rainfall-landslide occurrences) have been used: a calibration dataset (data from 2000 to 2007) and a validation dataset (2008-2009). Once the thresholds were defined, a WebGIS-based EWS has been implemented. In this system it is possible to focus both on monitoring of real-time data and on forecasting at different lead times up to 48 h; forecasting data are collected from LAMI (Limited Area Model Italy) rainfall forecasts. The EWS works on the basis of the threshold parameters defined by MaCumBA (I, D, NRG). An important feature of the warning system is that the visualization of the thresholds in the WebGIS interface may vary in time depending on when the starting time of the rainfall event is set. Therefore, the starting time of the rainfall event is considered as a variable by the system: whenever new rainfall data are available, a recursive algorithm identifies the starting time for which the rainfall path is closest to or overcomes the threshold. This is considered the most hazardous condition, and it is displayed by the WebGIS interface. One more issue that came to surface, after the EWS implementation, was the time-limited validity of the thresholds. On one hand rainfall thresholds can give good results, on the other hand their validity is limited in time, because of several factors, such as changes of pluviometric regime, land use and urban development. Furthermore, the availability of new landslide data can lead to more robust results. For the aforementioned reasons some of the thresholds defined for Tuscany region were updated, by using new landslide data (from 2010 to march 2013). A comparison between updated and former thresholds clearly shows that the performance of an EWS can be enhanced if the thresholds are constantly updated.

Update rules and interevent time distributions: slow ordering versus no ordering in the voter model.

PubMed

Fernández-Gracia, J; Eguíluz, V M; San Miguel, M

2011-07-01

We introduce a general methodology of update rules accounting for arbitrary interevent time (IET) distributions in simulations of interacting agents. We consider in particular update rules that depend on the state of the agent, so that the update becomes part of the dynamical model. As an illustration we consider the voter model in fully connected, random, and scale-free networks with an activation probability inversely proportional to the time since the last action, where an action can be an update attempt (an exogenous update) or a change of state (an endogenous update). We find that in the thermodynamic limit, at variance with standard updates and the exogenous update, the system orders slowly for the endogenous update. The approach to the absorbing state is characterized by a power-law decay of the density of interfaces, observing that the mean time to reach the absorbing state might be not well defined. The IET distributions resulting from both update schemes show power-law tails.

Thermal Protection of the Huygens Probe During Titan Entry: Last Questions

NASA Technical Reports Server (NTRS)

Bouilly, Jean-Marc

2005-01-01

CASSINI-HUYGENS mission is a cooperation between NASA and ESA, dedicated to the exploration of the Saturnian system. In the framework of this mission, the entry of the HUYGENS probe in the atmosphere of TITAN will be of major scientific interest. One of the essential points of the HUYGENS mission is therefore the good behavior of the thermal shield designed to maintain the aerodynamic shape and to protect the probe from excessive heating during the atmospheric entry on TITAN. The design and the qualification of this thermal shield were carried out between 1992 and 1995 (development phase). Currently, the final definition of mission parameters is being completed. As the performance of the thermal shield is one of all the parameters considered at system level, it is therefore necessary to reassess the thermal response of the TPS, taking into account some updated information that was not yet available during the development phase. After some recall of the results of 1992 to 1995, the paper will present a status of the current work on TPS.

Capillary glucose meter accuracy and sources of error in the ambulatory setting.

PubMed

Lunt, Helen; Florkowski, Christopher; Bignall, Michael; Budgen, Christopher

2010-03-05

Hand-held glucose meters are used throughout the health system by both patients with diabetes and also by health care practitioners. Glucose meter technology is constantly evolving. The current generation of meters and strips are quick to use and require a very small volume of blood. This review aims to describe meters currently available in New Zealand, for use in the ambulatory setting. It also aims to discuss the limits of meter performance and provide technical information that is relevant to the clinician, using locally available data. Commoner causes and consequences of end-user (patient and health professional) error are illustrated using clinical case examples. No meter offers definite advantages over other meters in all clinical situations, rather meters should be chosen because they fit the needs of individual patients and because the provider is able to offer appropriate educational and quality assurance backup to the meter user. A broad understanding of the advantages and disadvantages of the subsidised meter systems available in New Zealand will help the health practitioner decide when it is in the best interests of their patients to change or update meter technology.

[BALANCED SCORECARD AS A MANAGEMENT TOOL IN CLINICAL NUTRITION].

PubMed

Gutiérrez López, Cristina; Mauriz, Jose L; Culebras, Jesús M

2015-07-01

Nowadays, balanced scorecards have updated traditional management systems in the business sector. In this way, Kaplan and Norton propose performance measurement through several perspectives with a logical sequence: internal processes and learning impact client services, so that financial performance is affected. The aim of the present paper is to analyze the main characteristics of balanced scorecard when it is applied to non-for-profit companies and, specifically to the health sector in the clinical nutrition field. This model improves the economic vision of management with clinical indicators that represent healthcare professional's perspective. The balanced scorecard would allow a proper monitoring and tracking system for the main healthcare indicators. This contributes to a better control in comparison with standards that are associated with adequate quality assistance. Owing to the role of management accounting and cost calculations, the definition of healthcare professionals as clients or users, and clinical results relevance, it is necessary to adapt the balanced scorecard to the specific characteristics of the clinical field, redefining both perspectives and indicators. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Overview and Evaluation of the Community Multiscale Air ...

EPA Pesticide Factsheets

The Community Multiscale Air Quality (CMAQ) model is a state-of-the-science air quality model that simulates the emission, transport and fate of numerous air pollutants, including ozone and particulate matter. The Computational Exposure Division (CED) of the U.S. Environmental Protection Agency develops the CMAQ model and periodically releases new versions of the model that include bug fixes and various other improvements to the modeling system. In late 2016 or early 2017, CMAQ version 5.2 will be released. This new version of CMAQ will contain important updates from the current CMAQv5.1 modeling system, along with several instrumented versions of the model (e.g. decoupled direct method and sulfur tracking). Some specific model updates include the implementation of a new wind-blown dust treatment in CMAQv5.2, a significant improvement over the treatment in v5.1 which can severely overestimate wind-blown dust under certain conditions. Several other major updates to the modeling system include an update to the calculation of aerosols; implementation of full halogen chemistry (CMAQv5.1 contains a partial implementation of halogen chemistry); the new carbon bond 6 (CB6) chemical mechanism; updates to cloud model in CMAQ; and a new lightning assimilation scheme for the WRF model which significant improves the placement and timing of convective precipitation in the WRF precipitation fields. Numerous other updates to the modeling system will also be available in v5.2.

Medicaid Program; Mechanized Claims Processing and Information Retrieval Systems (90/10). Final rule.

PubMed

2015-12-04

This final rule will extend enhanced funding for Medicaid eligibility systems as part of a state's mechanized claims processing system, and will update conditions and standards for such systems, including adding to and updating current Medicaid Management Information Systems (MMIS) conditions and standards. These changes will allow states to improve customer service and support the dynamic nature of Medicaid eligibility, enrollment, and delivery systems.

Update on the Department of the Navy Systems Engineering Career Competency Model Acquisition Activities

DTIC Science & Technology

2016-04-30

Model Acquisition Activities Clifford Whitcomb, Systems Engineering Professor, NPS Corina White, Systems Engineering Research Associate, NPS...Engineering Acquisition Activities Karen Holness, Assistant Professor, NPS Update on the Department of the Navy Systems Engineering Career Competency Model ...Career Competency Model Clifford A. Whitcomb—is a Professor in the Systems Engineering Department at the Naval Postgraduate School, in Monterey, CA

Nocturnal hypoventilation in neuromuscular disease: prevalence according to different definitions issued from the literature.

PubMed

Ogna, Adam; Quera Salva, Maria-Antonia; Prigent, Helene; Mroue, Ghassane; Vaugier, Isabelle; Annane, Djillali; Lofaso, Frederic; Orlikowski, David

2016-05-01

Restrictive respiratory failure is a major cause of morbidity and mortality in neuromuscular diseases (NMD). Home mechanical ventilation (HMV) is used to treat hypoventilation, identified by daytime hypercapnia or nocturnal desaturation. Recently, transcutaneous measure of CO2 (TcCO2) has been increasingly used to detect hypoventilation, using different cut-offs. We aimed to compare the prevalence of hypoventilation in an unselected adult NMD population according to different definitions issued from the literature. All consecutive nocturnal capno-oximetries performed between 2010 and 2014 in unventilated adult NMD patients were analysed retrospectively. Concomitant blood gas analysis and lung function data were collected. Patients on oxygen therapy were excluded. Hypoventilation was defined according to eight criteria, based on daytime PaCO2, daytime base excess, nocturnal SpO2 or TcCO2. Data from 232 patients were analysed (mean age 43.1 ± 15.4 years; 50.0 % women; vital capacity 59.2 ± 24.2 % of predicted). The hypoventilation prevalence was 10.3 to 61.2 %, depending on the used definition. The different definitions showed 49.1 to 94.8 % concordance (Cohen's kappa for agreement 0.115 to 0.763). Overall agreement between the eight definitions was poor (Light's kappa 0.267), and agreement between definitions based on nocturnal SpO2 and those based on TcCO2 was even lower (Light's kappa 0.204). We found large differences in hypoventilation prevalence according to the used definition. This has practical consequences, as HMV indication relies upon hypoventilation detection. We believe that capno-oximetry should be included in the diagnostic tools used to detect hypoventilation but this requires an update of consensus guidelines to agree upon the best definition.

Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

PubMed Central

Shin, Jeong Eun; Jung, Hye-Kyung; Lee, Tae Hee; Jo, Yunju; Lee, Hyuk; Song, Kyung Ho; Hong, Sung Noh; Lim, Hyun Chul; Lee, Soon Jin; Chung, Soon Sup; Lee, Joon Seong; Rhee, Poong-Lyul; Lee, Kwang Jae; Choi, Suck Chei; Shin, Ein Soon

2016-01-01

The Korean Society of Neurogastroenterology and Motility first published guidelines for chronic constipation in 2005 and was updated in 2011. Although the guidelines were updated using evidence-based process, they lacked multidisciplinary participation and did not include a diagnostic approach for chronic constipation. This article includes guidelines for diagnosis and treatment of chronic constipation to realistically fit the situation in Korea and to be applicable to clinical practice. The guideline development was based upon the adaptation method because research evidence was limited in Korea, and an organized multidisciplinary group carried out systematical literature review and series of evidence-based evaluations. Six guidelines were selected using the Appraisal of Guidelines for Research & Evaluation (AGREE) II process. A total 37 recommendations were adopted, including 4 concerning the definition and risk factors of chronic constipation, 8 regarding diagnoses, and 25 regarding treatments. The guidelines are intended to help primary physicians and general health professionals in clinical practice in Korea, to provide the principles of medical treatment to medical students, residents, and other healthcare professionals, and to help patients for choosing medical services based on the information. These guidelines will be updated and revised periodically to reflect new diagnostic and therapeutic methods. PMID:27226437

Regeneration of Full Scale Adsorptive Media Systems - Update

EPA Science Inventory

Presentation provides an update of the regeneration studies conducted at Twentynine Palms, CA. Following a short introduction, the presentation summarizes the results of the three regeneration tests conducted on the exhausted media of the arsenic removal system at Twentynine Pal...

49 CFR 390.203 - PRISM State registration/biennial updates.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the Performance and Registration Information Systems Management (PRISM) program (authorized under... FEDERAL MOTOR CARRIER SAFETY REGULATIONS; GENERAL Unified Registration System § 390.203 PRISM State... procedures, provided the State has integrated the USDOT registration/update capability into its vehicle...

49 CFR 390.203 - PRISM State registration/biennial updates.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the Performance and Registration Information Systems Management (PRISM) program (authorized under... FEDERAL MOTOR CARRIER SAFETY REGULATIONS; GENERAL Unified Registration System § 390.203 PRISM State... procedures, provided the State has integrated the USDOT registration/update capability into its vehicle...

Data Link Benefits Study: National Sector Survey Update

DOT National Transportation Integrated Search

1995-06-15

Numerous changes have occurred in the National Airspace System since the spring : of 1994 when data was gathered for the original National Sector Survey, : conducted to gauge the effects of ATC delays on system users. This update : reflects those cha...

Joint Standing Committee on Education: Update on Higher Education Personnel Study

ERIC Educational Resources Information Center

West Virginia Higher Education Policy Commission, 2006

2006-01-01

The following topics are included in this update: (1) Comparison of West Virginia classification and compensation systems to those of the University of Michigan, the University system of Maryland, and the University of North Carolina; (2) Classification and Compensation System Training, including an agenda and summary of a two-day seminar devoted…

ballast water « Coast Guard Maritime Commons

Science.gov Websites

updates to Marine Safety Center's ballast water management system website The Marine Safety Center recently updated two tools posted to its ballast water management system website to assist industry when completing the ballast water management system type approval process, or when accessing letters of intent. 12

Commercial Vessel Compliance « Coast Guard Maritime Commons

Science.gov Websites

updates to Marine Safety Center's ballast water management system website The Marine Safety Center recently updated two tools posted to its ballast water management system website to assist industry when completing the ballast water management system type approval process, or when accessing letters of intent. 5

Patient-centred screening for primary immunodeficiency, a multi-stage diagnostic protocol designed for non-immunologists: 2011 update

PubMed Central

de Vries, E

2012-01-01

Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated the multi-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among doctors working in different fields. Prompt identification of PID is important for prognosis, but this may not be an easy task. The protocol therefore starts from the clinical presentation of the patient. Because PIDs may present at all ages, this protocol is aimed at both adult and paediatric physicians. The multi-stage design allows cost-effective screening for PID of the large number of potential cases in the early phases, with more expensive tests reserved for definitive classification in collaboration with a specialist in the field of immunodeficiency at a later stage. PMID:22132890

Length of stay following percutaneous coronary intervention: An expert consensus document update from the society for cardiovascular angiography and interventions.

PubMed

Seto, Arnold H; Shroff, Adhir; Abu-Fadel, Mazen; Blankenship, James C; Boudoulas, Konstantinos Dean; Cigarroa, Joaquin E; Dehmer, Gregory J; Feldman, Dmitriy N; Kolansky, Daniel M; Lata, Kusum; Swaminathan, Rajesh V; Rao, Sunil V

2018-04-24

Since the publication of the 2009 SCAI Expert Consensus Document on Length of Stay Following percutaneous coronary intervention (PCI), advances in vascular access techniques, stent technology, and antiplatelet pharmacology have facilitated changes in discharge patterns following PCI. Additional clinical studies have demonstrated the safety of early and same day discharge in selected patients with uncomplicated PCI, while reimbursement policies have discouraged unnecessary hospitalization. This consensus update: (1) clarifies clinical and reimbursement definitions of discharge strategies, (2) reviews the technological advances and literature supporting reduced hospitalization duration and risk assessment, and (3) describes changes to the consensus recommendations on length of stay following PCI (Supporting Information Table S1). These recommendations are intended to support reasonable clinical decision making regarding postprocedure length of stay for a broad spectrum of patients undergoing PCI, rather than prescribing a specific period of observation for individual patients. © 2018 Wiley Periodicals, Inc.

The recognition and management of sepsis and septic shock: a guide for non-intensivists.

PubMed

Keeley, Alexander; Hine, Paul; Nsutebu, Emmanuel

2017-10-01

Sepsis is common, often fatal and requires rapid interventions to improve outcomes. While the optimal management of sepsis in the intensive care setting is the focus of extensive research interest, the mainstay of the recognition and initial management of sepsis will occur outside the intensive care setting. Therefore, it is key that institutions and clinicians remain well informed of the current updates in sepsis management and continue to use them to deliver appropriate and timely interventions to enhance patient survival. This review discusses the latest updates in sepsis care including the new consensus definition of sepsis, the outcome of the proCESS, ProMISe and ARISE trials of early goal directed therapy (EGDT), and the most recent guidelines from the Surviving Sepsis Campaign. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

INHERITED NEUROPATHIES: CLINICAL OVERVIEW AND UPDATE

PubMed Central

KLEIN, CHRISTOPHER J.; DUAN, XIAOHUI; SHY, MICHAEL E.

2014-01-01

Inherited neuropathy is a group of common neurologic disorders with heterogeneous clinical presentations and genetic causes. Detailed neuromuscular evaluations, including nerve conduction studies, laboratory testing, and histopathologic examination, can assist in identification of the inherited component beyond family history. Genetic testing increasingly enables definitive diagnosis of specific inherited neuropathies. Diagnosis, however, is often complex, and neurologic disability may have both genetic and acquired components in individual patients. The decision of which genetic test to order or whether to order genetic tests is often complicated, and the strategies to maximize the value of testing are evolving. Apart from rare inherited metabolic neuropathies, treatment approaches remain largely supportive. We provide a clinical update of the various types of inherited neuropathies, their differential diagnoses, and distinguishing clinical features (where available). A framework is provided for clinical evaluations, including the inheritance assessment, electrophysiologic examinations, and specific genetic tests. PMID:23801417

Guideline from Japanese Society of Echocardiography: 2018 focused update incorporated into Guidance for the Management and Maintenance of Echocardiography Equipment.

PubMed

Daimon, Masao; Akaishi, Makoto; Asanuma, Toshihiko; Hashimoto, Shuji; Izumi, Chisato; Iwanaga, Shiro; Kawai, Hiroya; Toide, Hiroyuki; Hayashida, Akihiro; Yamada, Hirotsugu; Murata, Mitsushige; Hirano, Yutaka; Suzuki, Kengo; Nakatani, Satoshi

2018-03-01

Echocardiography plays a pivotal role as an imaging modality in the modern cardiology practice. Information derived from echocardiography is definitely helpful for a patient care. The Japanese Society of Echocardiography has promoted echocardiography for a routine clinical and research use. One of the missions of the Society is to provide information that is useful for high-quality examinations. To ensure it, we believe equipment in good conditions and a comfortable environment are important for both a patient and an examiner. Thus, the Committee for Guideline Writing, the Japanese Society of Echocardiography published brief guidance for the routine use of echocardiography equipment in 2015. Recently, the importance of international standardization has been emphasized in the medical laboratories. Accordingly, the committee has revised and updated our guidance for the routine use of echocardiography equipment.

Singapore Urological Association Clinical Guidelines for Male Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia

PubMed Central

2017-01-01

The first clinical guidelines for male lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) were published in 2005. An update is urgently needed in view of BPH being recognised as one of ten chronic illnesses by the Ministry of Health, Singapore. This review summarises the definition of BPH and the epidemiology of male LUTS/BPH in Singapore. BPH can be phenotyped with noninvasive transabdominal ultrasonography, according to intravesical prostatic protrusion and prostate volume, and classified according to severity (staging) for individualised treatment. At the initial evaluation, the majority of patients (59%) can be managed with fluid adjustment, exercise and diet; 32% with medications, using alpha blockers and/or 5-alpha reductase inhibitors for prostates weighing more than 30 g; and 9% with surgical intervention for more advanced disease. The 2015 guidelines comprise updated evidence that will help family medicine practitioners and specialists manage this common ailment more cost-effectively. PMID:28848988

Recurrent urinary tract infection.

PubMed

Epp, Annette; Larochelle, Annick

2010-11-01

to provide an update of the definition, epidemiology, clinical presentation, investigation, treatment, and prevention of recurrent urinary tract infections in women. continuous antibiotic prophylaxis, post-coital antibiotic prophylaxis, and acute self-treatment are all efficient alternatives to prevent recurrent urinary tract infection. Vaginal estrogen and cranberry juice can also be effective prophylaxis alternatives. a search of PubMed and The Cochrane Library for articles published in English identified the most relevant literature. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. There were no date restrictions. this update is the consensus of the Sub-Committee on Urogynaecology of the Society of Obstetricians and Gynaecologists of Canada. Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care (Table 1). recurrent urinary tract infections need careful investigation and can be efficiently treated and prevented. Different prophylaxis options can be selected according to each patient's characteristics.

Bioresearch Module Design Definition and Space Shuttle Vehicle Integration Study. Volume 1: Basic Report

NASA Technical Reports Server (NTRS)

Lang, A. L., Jr.

1971-01-01

Preliminary designs of the Bioexplorer spacecraft, developed in an earlier study program, are analyzed and updated to conform to a new specification which includes use of both the Scout and the space shuttle vehicle for launch. The updated spacecraft is referred to as bioresearch module. It is capable of supporting a variety of small biological experiments in near-earth and highly elliptical earth orbits. The baseline spacecraft design is compatible with the Scout launch vehicle. Inboard profile drawings, weight statements, interface drawings, and spacecraft parts and aerospace ground equipment lists are provided to document the design. The baseline design was analyzed to determine the design and cost impact of a set of optional features. These include reduced experiment power and thermal load, addition of an experiment television monitor, and replacement of VHF with S-band communications. The impact of these options on power required, weight change and cost is defined.

Three-phase Four-leg Inverter LabVIEW FPGA Control Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

In the area of power electronics control, Field Programmable Gate Arrays (FPGAs) have the capability to outperform their Digital Signal Processor (DSP) counterparts due to the FPGA’s ability to implement true parallel processing and therefore facilitate higher switching frequencies, higher control bandwidth, and/or enhanced functionality. National Instruments (NI) has developed two platforms, Compact RIO (cRIO) and Single Board RIO (sbRIO), which combine a real-time processor with an FPGA. The FPGA can be programmed with a subset of the well-known LabVIEW graphical programming language. The use of cRIO and sbRIO for power electronics control has developed over the last few yearsmore » to include control of three-phase inverters. Most three-phase inverter topologies include three switching legs. The addition of a fourth-leg to natively generate the neutral connection allows the inverter to serve single-phase loads in a microgrid or stand-alone power system and to balance the three-phase voltages in the presence of significant load imbalance. However, the control of a four-leg inverter is much more complex. In particular, instead of standard two-dimensional space vector modulation (SVM), the inverter requires three-dimensional space vector modulation (3D-SVM). The candidate software implements complete control algorithms in LabVIEW FPGA for a three-phase four-leg inverter. The software includes feedback control loops, three-dimensional space vector modulation gate-drive algorithms, advanced alarm handling capabilities, contactor control, power measurements, and debugging and tuning tools. The feedback control loops allow inverter operation in AC voltage control, AC current control, or DC bus voltage control modes based on external mode selection by a user or supervisory controller. The software includes the ability to synchronize its AC output to the grid or other voltage-source before connection. The software also includes provisions to allow inverter operation in parallel with other voltage regulating devices on the AC or DC buses. This flexibility allows the Inverter to operate as a stand-alone voltage source, connected to the grid, or in parallel with other controllable voltage sources as part of a microgrid or remote power system. In addition, as the inverter is expected to operate under severe unbalanced conditions, the software includes algorithms to accurately compute real and reactive power for each phase based on definitions provided in the IEEE Standard 1459: IEEE Standard Definitions for the Measurement of Electric Power Quantities Under Sinusoidal, Nonsinusoidal, Balanced, or Unbalanced Conditions. Finally, the software includes code to output analog signals for debugging and for tuning of control loops. The software fits on the Xilinx Virtex V LX110 FPGA embedded in the NI cRIO-9118 FPGA chassis, and with a 40 MHz base clock, supports a modulation update rate of 40 MHz, user-settable switching frequencies and synchronized control loop update rates of tens of kHz, and reference waveform generation, including Phase Lock Loop (PLL), update rate of 100 kHz.« less

Updating visual memory across eye movements for ocular and arm motor control.

PubMed

Thompson, Aidan A; Henriques, Denise Y P

2008-11-01

Remembered object locations are stored in an eye-fixed reference frame, so that every time the eyes move, spatial representations must be updated for the arm-motor system to reflect the target's new relative position. To date, studies have not investigated how the brain updates these spatial representations during other types of eye movements, such as smooth-pursuit. Further, it is unclear what information is used in spatial updating. To address these questions we investigated whether remembered locations of pointing targets are updated following smooth-pursuit eye movements, as they are following saccades, and also investigated the role of visual information in estimating eye-movement amplitude for updating spatial memory. Misestimates of eye-movement amplitude were induced when participants visually tracked stimuli presented with a background that moved in either the same or opposite direction of the eye before pointing or looking back to the remembered target location. We found that gaze-dependent pointing errors were similar following saccades and smooth-pursuit and that incongruent background motion did result in a misestimate of eye-movement amplitude. However, the background motion had no effect on spatial updating for pointing, but did when subjects made a return saccade, suggesting that the oculomotor and arm-motor systems may rely on different sources of information for spatial updating.

Updating Hawaii Seismicity Catalogs with Systematic Relocations and Subspace Detectors

NASA Astrophysics Data System (ADS)

Okubo, P.; Benz, H.; Matoza, R. S.; Thelen, W. A.

2015-12-01

We continue the systematic relocation of seismicity recorded in Hawai`i by the United States Geological Survey's (USGS) Hawaiian Volcano Observatory (HVO), with interests in adding to the products derived from the relocated seismicity catalogs published by Matoza et al., (2013, 2014). Another goal of this effort is updating the systematically relocated HVO catalog since 2009, when earthquake cataloging at HVO was migrated to the USGS Advanced National Seismic System Quake Management Software (AQMS) systems. To complement the relocation analyses of the catalogs generated from traditional STA/LTA event-triggered and analyst-reviewed approaches, we are also experimenting with subspace detection of events at Kilauea as a means to augment AQMS procedures for cataloging seismicity to lower magnitudes and during episodes of elevated volcanic activity. Our earlier catalog relocations have demonstrated the ability to define correlated or repeating families of earthquakes and provide more detailed definition of seismogenic structures, as well as the capability for improved automatic identification of diverse volcanic seismic sources. Subspace detectors have been successfully applied to cataloging seismicity in situations of low seismic signal-to-noise and have significantly increased catalog sensitivity to lower magnitude thresholds. We anticipate similar improvements using event subspace detections and cataloging of volcanic seismicity that include improved discrimination among not only evolving earthquake sequences but also diverse volcanic seismic source processes. Matoza et al., 2013, Systematic relocation of seismicity on Hawai`i Island from 1992 to 2009 using waveform cross correlation and cluster analysis, J. Geophys. Res., 118, 2275-2288, doi:10.1002/jgrb.580189 Matoza et al., 2014, High-precision relocation of long-period events beneath the summit region of Kīlauea Volcano, Hawai`i, from 1986 to 2009, Geophys. Res. Lett., 41, 3413-3421, doi:10.1002/2014GL059819

Prehospital care for multiple trauma patients in Germany.

PubMed

Maegele, Marc

2015-01-01

For the German speaking countries, Tscherne's definition of "polytrauma" which represents an injury of at least two body regions with one or a combination being life-threatening is still valid. The timely and adequate management including quick referral of the trauma patient into a designated trauma center may limit secondary injury and may thus improve outcomes already during the prehospital phase of care. The professional treatment of multiple injured trauma patients begins at the scene in the context of a well structured prehospital emergency medical system. The "Primary Survey" is performed by the emergency physician at the scene according to the Prehospital Trauma Life Support (PHTLS)-concept. The overall aim is to rapidly assess and treat life-threatening conditions even in the absence of patient history and diagnosis ("treat-first-what-kills-first"). If no immediate treatment is necessary, a "Secondary Sur- vey" follows with careful and structured body examination and detailed assessment of the trauma mechanism. Massive and life-threatening states of hemorrhage should be addressed immediately even disregarding the ABCDE-scheme. Critical trauma patients should be referred without any delay ("work and go")toTR-DGU® certified trauma centers of the local trauma networks. Due to the difficult pre- hospital environment the number of quality studies in the field is low and, as consequence, the level of evidence for most recommendations is also low. Much information has been obtained from different care systems and the interchangeability of results is limited. The present article provides a synopsis of rec- ommendations for early prehospital care for the severely injured based upon the 2011 updated multi- disciplinary S3-Guideline "Polytrauma/Schwerstverletzten Behandlung", the most recently updated European Trauma guideline and the current PHTLS-algorithms including grades of recommendation whenever possible.

75 FR 80823 - Agency Information Collection Activities: Proposed Collection; Comment Request; Guidance for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

...] Agency Information Collection Activities: Proposed Collection; Comment Request; Guidance for Industry on Updating Labeling for Susceptibility Test Information in Systemic Antibacterial Drug Products and... Industry on Updating Labeling for Susceptibility Test Information in Systemic Antibacterial Drug Products...