21 CFR 1308.15 - Schedule V.

Code of Federal Regulations, 2013 CFR

2013-04-01

... depressant effect on the central nervous system, including its salts: (1) Ezogabine [N-[2-amino-4-(4... which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers and salts of isomers: (1) Pyrovalerone 1485. (2) [Reserved] (e...

A computer software system for the generation of global ocean tides including self-gravitation and crustal loading effects

NASA Technical Reports Server (NTRS)

Estes, R. H.

1977-01-01

A computer software system is described which computes global numerical solutions of the integro-differential Laplace tidal equations, including dissipation terms and ocean loading and self-gravitation effects, for arbitrary diurnal and semidiurnal tidal constituents. The integration algorithm features a successive approximation scheme for the integro-differential system, with time stepping forward differences in the time variable and central differences in spatial variables. Solutions for M2, S2, N2, K2, K1, O1, P1 tidal constituents neglecting the effects of ocean loading and self-gravitation and a converged M2, solution including ocean loading and self-gravitation effects are presented in the form of cotidal and corange maps.

75 FR 57841 - List of Approved Spent Fuel Storage Casks: NAC-MPC System, Revision 6, Confirmation of Effective...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... Spent Fuel Storage Casks: NAC-MPC System, Revision 6, Confirmation of Effective Date AGENCY: Nuclear... include Amendment Number 6 to Certificate of Compliance (CoC) Number 1025. DATES: Effective Date: The... regulations at 10 CFR 72.214 to include Amendment No. 6 to CoC No. 1025. Amendment No. 6 changes the...

Computer program system for dynamic simulation and stability analysis of passive and actively controlled spacecraft. Volume 1. Theory

NASA Technical Reports Server (NTRS)

Bodley, C. S.; Devers, D. A.; Park, C. A.

1975-01-01

A theoretical development and associated digital computer program system is presented. The dynamic system (spacecraft) is modeled as an assembly of rigid and/or flexible bodies not necessarily in a topological tree configuration. The computer program system may be used to investigate total system dynamic characteristics including interaction effects between rigid and/or flexible bodies, control systems, and a wide range of environmental loadings. Additionally, the program system may be used for design of attitude control systems and for evaluation of total dynamic system performance including time domain response and frequency domain stability analyses. Volume 1 presents the theoretical developments including a description of the physical system, the equations of dynamic equilibrium, discussion of kinematics and system topology, a complete treatment of momentum wheel coupling, and a discussion of gravity gradient and environmental effects. Volume 2, is a program users' guide and includes a description of the overall digital program code, individual subroutines and a description of required program input and generated program output. Volume 3 presents the results of selected demonstration problems that illustrate all program system capabilities.

40 CFR 142.307 - What terms and conditions must be included in a small system variance?

Code of Federal Regulations, 2010 CFR

2010-07-01

... that may affect proper and effective operation and maintenance of the technology; (2) Monitoring... effective installation, operation and maintenance of the applicable small system variance technology in... health, which may include: (i) Public education requirements; and (ii) Source water protection...

Bulk electric system reliability evaluation incorporating wind power and demand side management

NASA Astrophysics Data System (ADS)

Huang, Dange

Electric power systems are experiencing dramatic changes with respect to structure, operation and regulation and are facing increasing pressure due to environmental and societal constraints. Bulk electric system reliability is an important consideration in power system planning, design and operation particularly in the new competitive environment. A wide range of methods have been developed to perform bulk electric system reliability evaluation. Theoretically, sequential Monte Carlo simulation can include all aspects and contingencies in a power system and can be used to produce an informative set of reliability indices. It has become a practical and viable tool for large system reliability assessment technique due to the development of computing power and is used in the studies described in this thesis. The well-being approach used in this research provides the opportunity to integrate an accepted deterministic criterion into a probabilistic framework. This research work includes the investigation of important factors that impact bulk electric system adequacy evaluation and security constrained adequacy assessment using the well-being analysis framework. Load forecast uncertainty is an important consideration in an electrical power system. This research includes load forecast uncertainty considerations in bulk electric system reliability assessment and the effects on system, load point and well-being indices and reliability index probability distributions are examined. There has been increasing worldwide interest in the utilization of wind power as a renewable energy source over the last two decades due to enhanced public awareness of the environment. Increasing penetration of wind power has significant impacts on power system reliability, and security analyses become more uncertain due to the unpredictable nature of wind power. The effects of wind power additions in generating and bulk electric system reliability assessment considering site wind speed correlations and the interactive effects of wind power and load forecast uncertainty on system reliability are examined. The concept of the security cost associated with operating in the marginal state in the well-being framework is incorporated in the economic analyses associated with system expansion planning including wind power and load forecast uncertainty. Overall reliability cost/worth analyses including security cost concepts are applied to select an optimal wind power injection strategy in a bulk electric system. The effects of the various demand side management measures on system reliability are illustrated using the system, load point, and well-being indices, and the reliability index probability distributions. The reliability effects of demand side management procedures in a bulk electric system including wind power and load forecast uncertainty considerations are also investigated. The system reliability effects due to specific demand side management programs are quantified and examined in terms of their reliability benefits.

Environmental interactions of the Space Station Freedom electric power system

NASA Technical Reports Server (NTRS)

Nahra, Henry K.; Lu, Cheng-Yi

1991-01-01

The Space Station Freedom operates in a low earth orbit (LEO) environment. Such operation results in different potential interactions with the Space Station systems including the Electric Power System (EPS). These potential interactions result in environmental effects which include neutral species effects such as atomic oxygen erosion, effects of micrometeoroid and orbital debris impacts, plasma effects, ionizing radiation, and induced contamination degradation effects. The EPS design and its interactions with the LEO environment are briefly described and the results of analyses and testing programs planned and performed thus far to resolve environmental concerns related to the EPS and its function in LEO environment.

Contributions of GABA to alcohol responsivity during adolescence: Insights from preclinical and clinical studies

PubMed Central

Silveri, Marisa M.

2015-01-01

There is a considerable body of literature demonstrating that adolescence is a unique age period, which includes rapid and dramatic maturation of behavioral, cognitive, hormonal and neurobiological systems. Most notably, adolescence is also a period of unique responsiveness to alcohol effects, with both hyposensitivity and hypersensitivity observed to the various effects of alcohol. Multiple neurotransmitter systems are undergoing fine-tuning during this critical period of brain development, including those that contribute to the rewarding effects of drugs of abuse. The role of developmental maturation of the γ-amino-butyric acid (GABA) system, however, has received less attention in contributing to age-specific alcohol sensitivities. This review integrates GABA findings from human magnetic resonance spectroscopy studies as they may translate to understanding adolescent-specific responsiveness to alcohol effects. Better understanding of the vulnerability of the GABA system both during adolescent development, and in psychiatric conditions that include alcohol dependence, could point to a putative mechanism, boosting brain GABA, that may have increased effectiveness for treating alcohol abuse disorders. PMID:24631274

Aerospace medicine and biology: A continuing bibliography with indexes (supplement 395)

NASA Technical Reports Server (NTRS)

1994-01-01

This bibliography lists 82 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during Nov. 1992. Subject coverage includes: general life sciences; aerospace medicine (including physiological factors, biological effects of radiation, and effects of weightlessness on man and animals); behavioral sciences (including psychological factors, individual and group behavior, crew training and evaluation, and psychic research); man/system technology and life support (including human engineering, biotechnology, and space suits and protective clothing) and space biology (including exobiology, planetary biology, and extraterrestrial life).

A summary report on system effectiveness and optimization study

NASA Technical Reports Server (NTRS)

Williamson, O. L.; Rydberg, A. J.; Dorris, G.

1973-01-01

Report treats optimization and effectiveness separately. Report illustrates example of dynamic programming solution to system optimization. Computer algorithm has been developed to solve effectiveness problem and is included in report.

Electromagnetic Environmental Effects System Testing

DTIC Science & Technology

2009-09-02

Procedure (TOP) 1-2-511 Electromagnetic Environmental Effects System Testing 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...airborne, sea, space, and ground systems , including associated ordnance, as stated in military standard (MIL-STD)-464A “Electromagnetic Environmental...Effects Requirement for Systems ”, as well as ADS-37A-PRF “Aeronautical Design Standard for the Electromagnetic Environmental Effects (E3) Performance and

Control of Initialized Fractional-Order Systems. Revised

NASA Technical Reports Server (NTRS)

Hartley, Tom T.; Lorenzo, Carl F.

2002-01-01

Due to the importance of historical effects in fractional-order systems, this paper presents a general fractional-order control theory that includes the time-varying initialization response. Previous studies have not properly accounted for these historical effects. The initialization response, along with the forced response, for fractional-order systems is determined. Stability properties of fractional-order systems are presented in the complex w-plane, which is a transformation of the s-plane. Time responses are discussed with respect to pole positions in the complex w-plane and frequency response behavior is included. A fractional-order vector space representation, which is a generalization of the state space concept, is presented including the initialization response. Control methods for vector representations of initialized fractional-order systems are shown. Nyquist, root-locus, and other input-output control methods are adapted to the control of fractional-order systems. Finally, the fractional-order differintegral is generalized to continuous order-distributions that have the possibility of including a continuum of fractional orders in a system element.

Control of Initialized Fractional-Order Systems

NASA Technical Reports Server (NTRS)

Hartly, Tom T.; Lorenzo, Carl F.

2002-01-01

Due to the importance of historical effects in fractional-order systems, this paper presents a general fractional-order control theory that includes the time-varying initialization response. Previous studies have not properly accounted for these historical effects. The initialization response, along with the forced response, for fractional-order systems is determined. Stability properties of fractional-order systems are presented in the complex Airplane, which is a transformation of the s-plane. Time responses are discussed with respect to pole positions in the complex Airplane and frequency response behavior is included. A fractional-order vector space representation, which is a generalization of the state space concept, is presented including the initialization response. Control methods for vector representations of initialized fractional-order systems are shown. Nyquist, root-locus, and other input-output control methods are adapted to the control of fractional-order systems. Finally, the fractional-order differintegral is generalized to continuous order-distributions that have the possibility of including a continuum of fractional orders in a system element.

CHECKPOINT INHIBITOR IMMUNE THERAPY: Systemic Indications and Ophthalmic Side Effects.

PubMed

Dalvin, Lauren A; Shields, Carol L; Orloff, Marlana; Sato, Takami; Shields, Jerry A

2018-06-01

To review immune checkpoint inhibitor indications and ophthalmic side effects. A literature review was performed using a PubMed search for publications between 1990 and 2017. Immune checkpoint inhibitors are designed to treat system malignancies by targeting one of three ligands, leading to T-cell activation for attack against malignant cells. These ligands (and targeted drug) include cytotoxic T-lymphocyte antigen-4 (CTLA-4, ipilimumab), programmed death protein 1 (PD-1, pembrolizumab, nivolumab), and programmed death ligand-1 (PD-L1, atezolizumab, avelumab, durvalumab). These medications upregulate the immune system and cause autoimmune-like side effects. Ophthalmic side effects most frequently manifest as uveitis (1%) and dry eye (1-24%). Other side effects include myasthenia gravis (n = 19 reports), inflammatory orbitopathy (n = 11), keratitis (n = 3), cranial nerve palsy (n = 3), optic neuropathy (n = 2), serous retinal detachment (n = 2), extraocular muscle myopathy (n = 1), atypical chorioretinal lesions (n = 1), immune retinopathy (n = 1), and neuroretinitis (n = 1). Most inflammatory side effects are managed with topical or periocular corticosteroids, but advanced cases require systemic corticosteroids and cessation of checkpoint inhibitor therapy. Checkpoint inhibitors enhance the immune system by releasing inhibition on T cells, with risk of autoimmune-like side effects. Ophthalmologists should include immune-related adverse events in their differential when examining cancer patients with new ocular symptoms.

A computer software system for the generation of global ocean tides including self-gravitation and crustal loading effects

NASA Technical Reports Server (NTRS)

Estes, R. H.

1977-01-01

A computer software system is described which computes global numerical solutions of the integro-differential Laplace tidal equations, including dissipation terms and ocean loading and self-gravitation effects, for arbitrary diurnal and semidiurnal tidal constituents. The integration algorithm features a successive approximation scheme for the integro-differential system, with time stepping forward differences in the time variable and central differences in spatial variables.

Dynamical properties of magnetized two-dimensional one-component plasma

NASA Astrophysics Data System (ADS)

Dubey, Girija S.; Gumbs, Godfrey; Fessatidis, Vassilios

2018-05-01

Molecular dynamics simulation are used to examine the effect of a uniform perpendicular magnetic field on a two-dimensional interacting electron system. In this simulation we include the effect of the magnetic field classically through the Lorentz force. Both the Coulomb and the magnetic forces are included directly in the electron dynamics to study their combined effect on the dynamical properties of the 2D system. Results are presented for the velocity autocorrelation function and the diffusion constants in the presence and absence of an external magnetic field. Our simulation results clearly show that the external magnetic field has an effect on the dynamical properties of the system.

System Noise Assessment and the Potential for a Low Noise Hybrid Wing Body Aircraft with Open Rotor Propulsion

NASA Technical Reports Server (NTRS)

Thomas, Russell H.; Burley, Casey L.; Lopes, Leonard V.; Bahr, Christopher J.; Gern, Frank H.; VanZante, Dale E.

2014-01-01

An aircraft system noise assessment was conducted for a hybrid wing body freighter aircraft concept configured with three open rotor engines. The primary objective of the study was to determine the aircraft system level noise given the significant impact of installation effects including shielding the open rotor noise by the airframe. The aircraft was designed to carry a payload of 100,000 lbs on a 6,500 nautical mile mission. An experimental database was used to establish the propulsion airframe aeroacoustic installation effects including those from shielding by the airframe planform, interactions with the control surfaces, and additional noise reduction technologies. A second objective of the study applied the impacts of projected low noise airframe technology and a projection of advanced low noise rotors appropriate for the NASA N+2 2025 timeframe. With the projection of low noise rotors and installation effects, the aircraft system level was 26.0 EPNLdB below Stage 4 level with the engine installed at 1.0 rotor diameters upstream of the trailing edge. Moving the engine to 1.5 rotor diameters brought the system level noise to 30.8 EPNLdB below Stage 4. At these locations on the airframe, the integrated level of installation effects including shielding can be as much as 20 EPNLdB cumulative in addition to lower engine source noise from advanced low noise rotors. And finally, an additional set of technology effects were identified and the potential impact at the system level was estimated for noise only without assessing the impact on aircraft performance. If these additional effects were to be included it is estimated that the potential aircraft system noise could reach as low as 38.0 EPNLdB cumulative below Stage 4.

Models and techniques for evaluating the effectiveness of aircraft computing systems

NASA Technical Reports Server (NTRS)

Meyer, J. F.

1978-01-01

The development of system models that can provide a basis for the formulation and evaluation of aircraft computer system effectiveness, the formulation of quantitative measures of system effectiveness, and the development of analytic and simulation techniques for evaluating the effectiveness of a proposed or existing aircraft computer are described. Specific topics covered include: system models; performability evaluation; capability and functional dependence; computation of trajectory set probabilities; and hierarchical modeling of an air transport mission.

The effect of aeration and effluent recycling on domestic wastewater treatment in a pilot-plant system of duckweed ponds.

PubMed

Ben-shalom, Miriam; Shandalov, Semion; Brenner, Asher; Oron, Gideon

2014-01-01

Three pilot-scale duckweed pond (DP) wastewater treatment systems were designed and operated to examine the effect of aeration and effluent recycling on treatment efficiency. Each system consisted of two DPs in series fed by pre-settled domestic sewage. The first system (duckweed+ conventional treatment) was 'natural' and included only duckweed plants. The second system (duckweed aeration) included aeration in the second pond. The third system (duckweed+ aeration+ circulation) included aeration in the second pond and effluent recycling from the second to the first pond. All three systems demonstrated similarly efficient removal of organic matter and nutrients. Supplemental aeration had no effect on either dissolved oxygen levels or on pollutant removal efficiencies. Although recycling had almost no influence on nutrient removal efficiencies, it had a positive impact on chemical oxygen demand and total suspended solids removals due to equalization of load and pH, which suppressed algae growth. Recycling also improved the appearance and growth rate of the duckweed plants, especially during heavy wastewater loads.

Conference on Correlations of Aging and Space Effects on Biosystems, Oct. 30-Nov. 1, 1989, Proceedings

NASA Technical Reports Server (NTRS)

Sprott, Richard L. (Editor); Combs, Carol A. (Editor)

1991-01-01

This volume includes papers on correlations between aging effects and space effects on biosystems, with particular attention given to the effects on the cardiovascular system, bone, sleep, cellular systems, immunological system, and genetics. Papers are presented on NASA and NIA plans and opportunities, the age effect on the posture and circulation, the cardiovascular physiology in space flight, and age-related bone changes. Attention is given to research on sleep, circulation rhythms, and aging and its applications to manned spaceflight; sleep and circadian rhythms; altered cell function in microgravity; and the heterogeneity of changes in lymphoproliferative ability with increasing age. Also included is a review of cellular immunosenescence, a paper on the immune response during space flight, and a paper on Caenorhabditis elegans as a model system for space biology studies.

14 CFR 25.941 - Inlet, engine, and exhaust compatibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., engine, and exhaust compatibility. For airplanes using variable inlet or exhaust system geometry, or both— (a) The system comprised of the inlet, engine (including thrust augmentation systems, if incorporated... configurations; (b) The dynamic effects of the operation of these (including consideration of probable...

21 CFR 1308.13 - Schedule III.

Code of Federal Regulations, 2014 CFR

2014-04-01

... a stimulant effect on the central nervous system, including its salts, isomers (whether optical... any quantity of the following substances having a depressant effect on the central nervous system: (1...

21 CFR 1308.13 - Schedule III.

Code of Federal Regulations, 2012 CFR

2012-04-01

... a stimulant effect on the central nervous system, including its salts, isomers (whether optical... any quantity of the following substances having a depressant effect on the central nervous system: (1...

21 CFR 1308.13 - Schedule III.

Code of Federal Regulations, 2013 CFR

2013-04-01

... a stimulant effect on the central nervous system, including its salts, isomers (whether optical... any quantity of the following substances having a depressant effect on the central nervous system: (1...

Bending of I-beam with the transvers shear effect included - FEM calculated

NASA Astrophysics Data System (ADS)

Grygorowicz, Magdalena; Lewiński, Jerzy

2016-06-01

The paper is devoted to three-point bending of an I-beam with include of transvers shear effect. Numerical calculations were conducted independently with the use of the SolidWorks system and the multi-purpose software package ANSYS The results of FEM study conducted with the use of two systems were compared and presented in tables and figures.

Bending of I-beam with the transvers shear effect included – FEM calculated

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grygorowicz, Magdalena; Lewiński, Jerzy

2016-06-08

The paper is devoted to three-point bending of an I-beam with include of transvers shear effect. Numerical calculations were conducted independently with the use of the SolidWorks system and the multi-purpose software package ANSYS The results of FEM study conducted with the use of two systems were compared and presented in tables and figures.

Develop a PWL System for Dense Graded Hot Mix Asphalt Construction, Including Pay Factors

DOT National Transportation Integrated Search

2015-01-01

This research project developed a PWL system that the Nevada DOT can effectively implement on the construction of dense graded HMA mixtures. The PWL system includes pay factors that are based on pavement performance indicators such as rutting and cra...

Teacher Effectiveness: An Update on Pennsylvania's Teacher Evaluation System. Issue Brief

ERIC Educational Resources Information Center

Research For Action, 2013

2013-01-01

Act 82 of 2012 established new standards for Pennsylvania's teacher evaluation system, including the incorporation of student performance measures in ratings decisions. Since 2009, approximately 35 states have amended teacher evaluation systems, with student achievement playing an increasingly prominent role. This count includes neighboring…

Use of animal models for space flight physiology studies, with special focus on the immune system

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald

2005-01-01

Animal models have been used to study the effects of space flight on physiological systems. The animal models have been used because of the limited availability of human subjects for studies to be carried out in space as well as because of the need to carry out experiments requiring samples and experimental conditions that cannot be performed using humans. Experiments have been carried out in space using a variety of species, and included developmental biology studies. These species included rats, mice, non-human primates, fish, invertebrates, amphibians and insects. The species were chosen because they best fit the experimental conditions required for the experiments. Experiments with animals have also been carried out utilizing ground-based models that simulate some of the effects of exposure to space flight conditions. Most of the animal studies have generated results that parallel the effects of space flight on human physiological systems. Systems studied have included the neurovestibular system, the musculoskeletal system, the immune system, the neurological system, the hematological system, and the cardiovascular system. Hindlimb unloading, a ground-based model of some of the effects of space flight on the immune system, has been used to study the effects of space flight conditions on physiological parameters. For the immune system, exposure to hindlimb unloading has been shown to results in alterations of the immune system similar to those observed after space flight. This has permitted the development of experiments that demonstrated compromised resistance to infection in rodents maintained in the hindlimb unloading model as well as the beginning of studies to develop countermeasures to ameliorate or prevent such occurrences. Although there are limitations to the use of animal models for the effects of space flight on physiological systems, the animal models should prove very valuable in designing countermeasures for exploration class missions of the future.

The effectiveness of education in the recognition and management of deteriorating patients: A systematic review.

PubMed

Connell, Clifford J; Endacott, Ruth; Jackman, Jennifer A; Kiprillis, Noelleen R; Sparkes, Louise M; Cooper, Simon J

2016-09-01

Survival from in-hospital cardiac arrest is poor. Clinical features, including abnormal vital signs, often indicate patient deterioration prior to severe adverse events. Early warning systems and rapid response teams are commonly used to assist the health profession in the identification and management of the deteriorating patient. Education programs are widely used in the implementation of these systems. The effectiveness of the education is unknown. The aims of this study were to identify: (i) the evidence supporting educational effectiveness in the recognition and management of the deteriorating patient and (ii) outcome measures used to evaluate educational effectiveness. A mixed methods systematic review of the literature was conducted using studies published between 2002 and 2014. Included studies were assessed for quality and data were synthesized thematically, while original data are presented in tabular form. Twenty-three studies were included in the review. Most educational programs were found to be effective reporting significant positive impacts upon learners, patient outcomes and organisational systems. Outcome measures related to: i learners, for example knowledge and performance, ii systems, including activation and responses of rapid response teams, and iii patients, including patient length of stay and adverse events. All but one of the programs used blended teaching with >87% including medium to high fidelity simulation. In situ simulation was employed in two of the interventions. The median program time was eight hours. The longest program lasted 44h however one of the most educationally effective programs was based upon a 40min simulation program. Educational interventions designed to improve the recognition and management of patient deterioration can improve learner outcomes when they incorporate medium to high-fidelity simulation. High-fidelity simulation has demonstrated effectiveness when delivered in brief sessions lasting only forty minutes. In situ simulation has demonstrated sustained positive impact upon the real world implementation of rapid response systems. Outcome measures should include knowledge and skill developments but there are important benefits in understanding patient outcomes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Diesel exhaust exposure, its multi-system effects, and the effect of new technology diesel exhaust.

PubMed

Reis, Haley; Reis, Cesar; Sharip, Akbar; Reis, Wenes; Zhao, Yong; Sinclair, Ryan; Beeson, Lawrence

2018-05-01

Exposure to diesel exhaust (DE) from vehicles and industry is hazardous and affects proper function of organ systems. DE can interfere with normal physiology after acute and chronic exposure to particulate matter (PM). Exposure leads to potential systemic disease processes in the central nervous, visual, hematopoietic, respiratory, cardiovascular, and renal systems. In this review, we give an overview of the epidemiological evidence supporting the harmful effects of diesel exhaust, and the numerous animal studies conducted to investigate the specific pathophysiological mechanisms behind DE exposure. Additionally, this review includes a summary of studies that used biomarkers as an indication of biological plausibility, and also studies evaluating new technology diesel exhaust (NTDE) and its systemic effects. Lastly, this review includes new approaches to improving DE emissions, and emphasizes the importance of ongoing study in this field of environmental health. Copyright © 2018 Elsevier Ltd. All rights reserved.

Decontamination of metals using chemical etching

DOEpatents

Lerch, Ronald E.; Partridge, Jerry A.

1980-01-01

The invention relates to chemical etching process for reclaiming contaminated equipment wherein a reduction-oxidation system is included in a solution of nitric acid to contact the metal to be decontaminated and effect reduction of the reduction-oxidation system, and includes disposing a pair of electrodes in the reduced solution to permit passage of an electrical current between said electrodes and effect oxidation of the reduction-oxidation system to thereby regenerate the solution and provide decontaminated equipment that is essentially radioactive contamination-free.

Control-system techniques for improved departure/spin resistance for fighter aircraft

NASA Technical Reports Server (NTRS)

Nguyen, L. T.; Gilbert, W. P.; Ogburn, M. E.

1980-01-01

Some fundamental information on control system effects on controllability of highly maneuverable aircraft at high angles of attack are summarized as well as techniques for enhancing fighter aircraft departure/spin resistance using control system design. The discussion includes: (1) a brief review of pertinent high angle of attack phenomena including aerodynamics, inertia coupling, and kinematic coupling; (2) effects of conventional stability augmentation systems at high angles of attack; (3) high angle of attack control system concepts designed to enhance departure/spin resistance; and (4) the outlook for applications of these concepts to future fighters, particularly those designs which incorporate relaxed static stability.

The effects of caffeine on the cholinergic system.

PubMed

Pohanka, Miroslav

2014-01-01

Caffeine is a secondary metabolite of tea and coffee plants. It is the active psychostimulant ingredient of widely consumed beverages, chocolate and some drugs as well. The major pathways for caffeine including interaction with adenosine receptors have been identified but caffeine has several minor pathways as well that remain poorly understood including the cholinergic system. Given the role of caffeine in the cholinergic system, some molecular targets have been tracked and a mechanism of its action has been proposed in research studies. However, the biological effect of caffeine on the cholinergic system is not completely understood. The present review focuses on the role of caffeine in the cholinergic system.

Water reuse systems: A review of the principal components

USGS Publications Warehouse

Lucchetti, G.; Gray, G.A.

1988-01-01

Principal components of water reuse systems include ammonia removal, disease control, temperature control, aeration, and particulate filtration. Effective ammonia removal techniques include air stripping, ion exchange, and biofiltration. Selection of a particular technique largely depends on site-specific requirements (e.g., space, existing water quality, and fish densities). Disease control, although often overlooked, is a major problem in reuse systems. Pathogens can be controlled most effectively with ultraviolet radiation, ozone, or chlorine. Simple and inexpensive methods are available to increase oxygen concentration and eliminate gas supersaturation, these include commercial aerators, air injectors, and packed columns. Temperature control is a major advantage of reuse systems, but the equipment required can be expensive, particularly if water temperature must be rigidly controlled and ambient air temperature fluctuates. Filtration can be readily accomplished with a hydrocyclone or sand filter that increases overall system efficiency. Based on criteria of adaptability, efficiency, and reasonable cost, we recommend components for a small water reuse system.

Exposure to 3,3’,4,4’,5-pentachlorobiphenyl (PCB 126) impacts multiple organ systems in developing little skate (Leucoraja erinacea)

EPA Science Inventory

Effects of exposure to coplanar polychlorinated biphenyls (PCBs) and other dioxin-like chemicals on developing vertebrates involve many organ systems, including the skeletal and cardiovascular systems. Apex predators, including those from the class Chondrichthyes (sharks, skates,...

Exposure to 3,3’,4,4’,5-pentachlorobiphenyl (PCB 126) impacts multiple organ systems in developing little skate (Leucoraja erinacea).

EPA Science Inventory

Effects of exposure to coplanar polychlorinated biphenyls (PCBs) and other dioxin-like chemicals on developing vertebrates involve many organ systems, including the skeletal and cardiovascular systems. Apex predators, including those from the class Chondrichthyes (sharks, skates,...

Mobile Delivery of Treatment for Alcohol Use Disorders

PubMed Central

Quanbeck, Andrew; Chih, Ming-Yuan; Isham, Andrew; Johnson, Roberta; Gustafson, David

2014-01-01

Several systems for treating alcohol-use disorders (AUDs) exist that operate on mobile phones. These systems are categorized into four groups: text-messaging monitoring and reminder systems, text-messaging intervention systems, comprehensive recovery management systems, and game-based systems. Text-messaging monitoring and reminder systems deliver reminders and prompt reporting of alcohol consumption, enabling continuous monitoring of alcohol use. Text-messaging intervention systems additionally deliver text messages designed to promote abstinence and recovery. Comprehensive recovery management systems use the capabilities of smart-phones to provide a variety of tools and services that can be tailored to individuals, including in-the-moment assessments and access to peer discussion groups. Game-based systems engage the user using video games. Although many commercial applications for treatment of AUDs exist, few (if any) have empirical evidence of effectiveness. The available evidence suggests that although texting-based applications may have beneficial effects, they are probably insufficient as interventions for AUDs. Comprehensive recovery management systems have the strongest theoretical base and have yielded the strongest and longest-lasting effects, but challenges remain, including cost, understanding which features account for effects, and keeping up with technological advances. PMID:26259005

75 FR 53586 - Bifenazate; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... characterized and were seen at dose(s) that produce evidence of overt systemic toxicity. These effects included... system, and these findings may be due to secondary effect of overt systemic toxicity. Further, there is... Adequate enforcement methodology is available to enforce the tolerance expression. High-performance liquid...

Formative assessment in physiology teaching using a wireless classroom communication system.

PubMed

Paschal, Cynthia B

2002-12-01

Systems physiology, studied by biomedical engineers, is an analytical way to approach the homeostatic foundations of basic physiology. In many systems physiology courses, students attend lectures and are given homework and reading assignments to complete outside of class. The effectiveness of this traditional approach was compared with an approach in which a wireless classroom communication system was used to provide instant feedback on in-class learning activities and reading assignment quizzes. Homework was eliminated in this approach. The feedback system used stimulated 100% participation in class and facilitated rapid formative assessment. The results of this study indicate that learning of systems physiology concepts including physiology is at least, as if not more, effective when in-class quizzes and activities with instant feedback are used in place of traditional learning activities including homework. When results of this study are interpreted in light of possible effects of the September 11, 2001 terrorist attacks on student learning in the test group, it appears that the modified instruction may be more effective than the traditional instruction.

A 4-cylinder Stirling engine computer program with dynamic energy equations

NASA Technical Reports Server (NTRS)

Daniele, C. J.; Lorenzo, C. F.

1983-01-01

A computer program for simulating the steady state and transient performance of a four cylinder Stirling engine is presented. The thermodynamic model includes both continuity and energy equations and linear momentum terms (flow resistance). Each working space between the pistons is broken into seven control volumes. Drive dynamics and vehicle load effects are included. The model contains 70 state variables. Also included in the model are piston rod seal leakage effects. The computer program includes a model of a hydrogen supply system, from which hydrogen may be added to the system to accelerate the engine. Flow charts are provided.

Warning systems in risk management.

PubMed

Paté-Cornell, M E

1986-06-01

A method is presented here that allows probabilistic evaluation and optimization of warning systems, and comparison of their performance and cost-effectiveness with those of other means of risk management. The model includes an assessment of the signals, and of human response, given the memory that people have kept of the quality of previous alerts. The trade-off between the rate of false alerts and the length of the lead time is studied to account for the long-term effects of "crying wolf" and the effectiveness of emergency actions. An explicit formulation of the system's benefits, including inputs from a signal model, a response model, and a consequence model, is given to allow optimization of the warning threshold and of the system's sensitivity.

The neuroscience of placebo effects: connecting context, learning and health

PubMed Central

Wager, Tor D.; Atlas, Lauren Y.

2018-01-01

Placebo effects are beneficial effects that are attributable to the brain–mind responses to the context in which a treatment is delivered rather than to the specific actions of the drug. They are mediated by diverse processes — including learning, expectations and social cognition — and can influence various clinical and physiological outcomes related to health. Emerging neuroscience evidence implicates multiple brain systems and neurochemical mediators, including opioids and dopamine. We present an empirical review of the brain systems that are involved in placebo effects, focusing on placebo analgesia, and a conceptual framework linking these findings to the mind–brain processes that mediate them. This framework suggests that the neuropsychological processes that mediate placebo effects may be crucial for a wide array of therapeutic approaches, including many drugs. PMID:26087681

An Examination of Leadership Types among Generation Y and Its Impact on Virtual Team Effectiveness

ERIC Educational Resources Information Center

Graham, C. Matt

2013-01-01

The majority of database system development projects end in failure. Reasons that include, the system not being developed on time, the system was developed over budget, and the system developed did not meet the planned project's criteria. These failures are compounded by the use of virtual teams which includes problems with team formation, the…

Assessment of Alternative Student and Delivery Systems: Assessment of the Current Delivery System. Supplement I to the Final Report.

ERIC Educational Resources Information Center

Advanced Technology, Inc., Reston, VA.

The effects of the current student financial aid delivery system on five major participant groups are examined: federal government, states/guarantee agencies, postsecondary institutions, lenders and secondary markets, and applicants and families. Attention is directed to effects of the current system, including: administrative costs, fund…

Classification systems for causes of stillbirth and neonatal death, 2009-2014: an assessment of alignment with characteristics for an effective global system.

PubMed

Leisher, Susannah Hopkins; Teoh, Zheyi; Reinebrant, Hanna; Allanson, Emma; Blencowe, Hannah; Erwich, Jan Jaap; Frøen, J Frederik; Gardosi, Jason; Gordijn, Sanne; Gülmezoglu, A Metin; Heazell, Alexander E P; Korteweg, Fleurisca; Lawn, Joy; McClure, Elizabeth M; Pattinson, Robert; Smith, Gordon C S; Tunçalp, Ӧzge; Wojcieszek, Aleena M; Flenady, Vicki

2016-09-15

To reduce the burden of 5.3 million stillbirths and neonatal deaths annually, an understanding of causes of deaths is critical. A systematic review identified 81 systems for classification of causes of stillbirth (SB) and neonatal death (NND) between 2009 and 2014. The large number of systems hampers efforts to understand and prevent these deaths. This study aimed to assess the alignment of current classification systems with expert-identified characteristics for a globally effective classification system. Eighty-one classification systems were assessed for alignment with 17 characteristics previously identified through expert consensus as necessary for an effective global system. Data were extracted independently by two authors. Systems were assessed against each characteristic and weighted and unweighted scores assigned to each. Subgroup analyses were undertaken by system use, setting, type of death included and type of characteristic. None of the 81 systems were aligned with more than 9 of the 17 characteristics; most (82 %) were aligned with four or fewer. On average, systems were aligned with 19 % of characteristics. The most aligned system (Frøen 2009-Codac) still had an unweighted score of only 9/17. Alignment with individual characteristics ranged from 0 to 49 %. Alignment was somewhat higher for widely used as compared to less used systems (22 % v 17 %), systems used only in high income countries as compared to only in low and middle income countries (20 % vs 16 %), and systems including both SB and NND (23 %) as compared to NND-only (15 %) and SB-only systems (13 %). Alignment was higher with characteristics assessing structure (23 %) than function (15 %). There is an unmet need for a system exhibiting all the characteristics of a globally effective system as defined by experts in the use of systems, as none of the 81 contemporary classification systems assessed was highly aligned with these characteristics. A particular concern in terms of global effectiveness is the lack of alignment with "ease of use" among all systems, including even the most-aligned. A system which meets the needs of users would have the potential to become the first truly globally effective classification system.

Radiation Requirements and Requirements Flowdown: Single Event Effects (SEEs) and Requirements

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.

2002-01-01

This short course session provides: (1) an overview of the single particle-induced hazard for space system as they apply in the natural space environment. This shall focus on the implementation of a single event effect hardness assurance (SEEHA) program for systems including system engineering approach and mitigation of effects. (2) The final portion of this session shell provide relevant real-life examples of in-flight performance of systems.

The transfer of safety training in work organizations: a systems perspective to continuous learning.

PubMed

Ford, J K; Fisher, S

1994-01-01

The effectiveness of safety and health programs can be evaluated from a "transfer" perspective, which evaluates the effectiveness of training in individual programs, and from a "systems" perspective that contends that a safety training program cannot be isolated from the organizational system of which it is a part. This chapter explores the effectiveness of training from a systems perspective and includes recommendations for improving safety and health training.

Cost-effectiveness and performance of overlay systems in Illinois, volume 1 : effectiveness assessment of HMA overlay interlayer systems used to retard reflective cracking.

DOT National Transportation Integrated Search

2009-05-01

This project evaluated the ability of interlayer systems used in HMA overlays to retard reflective cracking. Field : crack surveys and forensic investigation, including video imaging and ground penetrating radar surveys as well : as laboratory testin...

40 CFR 63.689 - Standards: Transfer systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the cover edge and its mounting. (3) Except for the inlet and outlet openings to the transfer system... include: organic vapor permeability; the effects of any contact with the material or its vapors conveyed in the transfer system; the effects of outdoor exposure to wind, moisture, and sunlight; and the...

40 CFR 63.689 - Standards: Transfer systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the cover edge and its mounting. (3) Except for the inlet and outlet openings to the transfer system... include: organic vapor permeability; the effects of any contact with the material or its vapors conveyed in the transfer system; the effects of outdoor exposure to wind, moisture, and sunlight; and the...

40 CFR 63.689 - Standards: Transfer systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the cover edge and its mounting. (3) Except for the inlet and outlet openings to the transfer system... include: organic vapor permeability; the effects of any contact with the material or its vapors conveyed in the transfer system; the effects of outdoor exposure to wind, moisture, and sunlight; and the...

40 CFR 63.689 - Standards: Transfer systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the cover edge and its mounting. (3) Except for the inlet and outlet openings to the transfer system... include: organic vapor permeability; the effects of any contact with the material or its vapors conveyed in the transfer system; the effects of outdoor exposure to wind, moisture, and sunlight; and the...

Design of a Solar Sail Mission to Mars

NASA Technical Reports Server (NTRS)

Eastridge, Richard; Funston, Kerry; Okia, Aminat; Waldrop, Joan; Zimmerman, Christopher

1989-01-01

An evaluation of the design of the solar sail includes key areas such as structures, sail deployment, space environmental effects, materials, power systems, telemetry, communications, attitude control, thermal control, and trajectory analysis. Deployment and material constraints determine the basic structure of the sail, while the trajectory of the sail influences the choice of telemetry, communications, and attitude control systems. The thermal control system of the sail for the structures and electronics takes into account the effects of the space environment. Included also are a cost and weight estimate for the sail.

Covariant effective action for a Galilean invariant quantum Hall system

NASA Astrophysics Data System (ADS)

Geracie, Michael; Prabhu, Kartik; Roberts, Matthew M.

2016-09-01

We construct effective field theories for gapped quantum Hall systems coupled to background geometries with local Galilean invariance i.e. Bargmann spacetimes. Along with an electromagnetic field, these backgrounds include the effects of curved Galilean spacetimes, including torsion and a gravitational field, allowing us to study charge, energy, stress and mass currents within a unified framework. A shift symmetry specific to single constituent theories constraints the effective action to couple to an effective background gauge field and spin connection that is solved for by a self-consistent equation, providing a manifestly covariant extension of Hoyos and Son's improvement terms to arbitrary order in m.

Identification and stochastic control of helicopter dynamic modes

NASA Technical Reports Server (NTRS)

Molusis, J. A.; Bar-Shalom, Y.

1983-01-01

A general treatment of parameter identification and stochastic control for use on helicopter dynamic systems is presented. Rotor dynamic models, including specific applications to rotor blade flapping and the helicopter ground resonance problem are emphasized. Dynamic systems which are governed by periodic coefficients as well as constant coefficient models are addressed. The dynamic systems are modeled by linear state variable equations which are used in the identification and stochastic control formulation. The pure identification problem as well as the stochastic control problem which includes combined identification and control for dynamic systems is addressed. The stochastic control problem includes the effect of parameter uncertainty on the solution and the concept of learning and how this is affected by the control's duel effect. The identification formulation requires algorithms suitable for on line use and thus recursive identification algorithms are considered. The applications presented use the recursive extended kalman filter for parameter identification which has excellent convergence for systems without process noise.

Medical Devices Transition to Information Systems: Lessons Learned

PubMed Central

Charters, Kathleen G.

2012-01-01

Medical devices designed to network can share data with a Clinical Information System (CIS), making that data available within clinician workflow. Some lessons learned by transitioning anesthesia reporting and monitoring devices (ARMDs) on a local area network (LAN) to integration of anesthesia documentation within a CIS include the following categories: access, contracting, deployment, implementation, planning, security, support, training and workflow integration. Areas identified for improvement include: Vendor requirements for access reconciled with the organizations’ security policies and procedures. Include clauses supporting transition from stand-alone devices to information integrated into clinical workflow in the medical device procurement contract. Resolve deployment and implementation barriers that make the process less efficient and more costly. Include effective field communication and creative alternatives in planning. Build training on the baseline knowledge of trainees. Include effective help desk processes and metrics. Have a process for determining where problems originate when systems share information. PMID:24199054

Safety of High Speed Guided Ground Transportation Systems. Broadband Magnetic Fields : Their Possible Role in EMF Associated Bioeffects

DOT National Transportation Integrated Search

1993-08-01

This report reviews electric and magnetic field (EMF) exposures from electrical transportation systems, including : electrically powered rail and magnetic levitation (maglev). Material also covered includes research concerning : biological effects of...

77 FR 749 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-06

... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... orders that include information technology (IT) supplies, services and systems. DATES: Effective Date... 6, 2012 that include information technology (IT) supplies, services and systems with security...

Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain

PubMed Central

Olson, Keith M.; Lei, Wei; Keresztes, Attila; LaVigne, Justin; Streicher, John M.

2017-01-01

Opioid drugs like morphine and fentanyl are the gold standard for treating moderate to severe acute and chronic pain. However, opioid drug use can be limited by serious side effects, including constipation, tolerance, respiratory suppression, and addiction. For more than 100 years, we have tried to develop opioids that decrease or eliminate these liabilities, with little success. Recent advances in understanding opioid receptor signal transduction have suggested new possibilities to activate the opioid receptors to cause analgesia, while reducing or eliminating unwanted side effects. These new approaches include designing functionally selective ligands, which activate desired signaling cascades while avoiding signaling cascades that are thought to provoke side effects. It may also be possible to directly modulate downstream signaling through the use of selective activators and inhibitors. Separate from downstream signal transduction, it has also been found that when the opioid system is stimulated, various negative feedback systems are upregulated to compensate, which can drive side effects. This has led to the development of multi-functional molecules that simultaneously activate the opioid receptor while blocking various negative feedback receptor systems including cholecystokinin and neurokinin-1. Other novel approaches include targeting heterodimers of the opioid and other receptor systems which may drive side effects, and making endogenous opioid peptides druggable, which may also reduce opioid mediated side effects. Taken together, these advances in our molecular understanding provide a path forward to break the barrier in producing an opioid with reduced or eliminated side effects, especially addiction, which may provide relief for millions of patients. PMID:28356897

The effects of scene content parameters, compression, and frame rate on the performance of analytics systems

NASA Astrophysics Data System (ADS)

Tsifouti, A.; Triantaphillidou, S.; Larabi, M. C.; Doré, G.; Bilissi, E.; Psarrou, A.

2015-01-01

In this investigation we study the effects of compression and frame rate reduction on the performance of four video analytics (VA) systems utilizing a low complexity scenario, such as the Sterile Zone (SZ). Additionally, we identify the most influential scene parameters affecting the performance of these systems. The SZ scenario is a scene consisting of a fence, not to be trespassed, and an area with grass. The VA system needs to alarm when there is an intruder (attack) entering the scene. The work includes testing of the systems with uncompressed and compressed (using H.264/MPEG-4 AVC at 25 and 5 frames per second) footage, consisting of quantified scene parameters. The scene parameters include descriptions of scene contrast, camera to subject distance, and attack portrayal. Additional footage, including only distractions (no attacks) is also investigated. Results have shown that every system has performed differently for each compression/frame rate level, whilst overall, compression has not adversely affected the performance of the systems. Frame rate reduction has decreased performance and scene parameters have influenced the behavior of the systems differently. Most false alarms were triggered with a distraction clip, including abrupt shadows through the fence. Findings could contribute to the improvement of VA systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fajardo, E. A.; Zülicke, U.; Winkler, R.

We discuss the universal spin dynamics in quasi-one-dimensional systems including the real spin in narrow-gap semiconductors like InAs and InSb, the valley pseudospin in staggered single-layer graphene, and the combination of real spin and valley pseudospin characterizing single-layer transition metal dichalcogenides (TMDCs) such as MoS2, WS2, MoS2, and WSe2. All these systems can be described by the same Dirac-like Hamiltonian. Spin-dependent observable effects in one of these systems thus have counterparts in each of the other systems. Effects discussed in more detail include equilibrium spin currents, current-induced spin polarization (Edelstein effect), and spin currents generated via adiabatic spin pumping. Ourmore » work also suggests that a long-debated spin-dependent correction to the position operator in single-band models should be absent.« less

The effectiveness of physiologically based early warning or track and trigger systems after triage in adult patients presenting to emergency departments: a systematic review.

PubMed

Wuytack, Francesca; Meskell, Pauline; Conway, Aislinn; McDaid, Fiona; Santesso, Nancy; Hickey, Fergal G; Gillespie, Paddy; Raymakers, Adam J N; Smith, Valerie; Devane, Declan

2017-12-06

Changes to physiological parameters precede deterioration of ill patients. Early warning and track and trigger systems (TTS) use routine physiological measurements with pre-specified thresholds to identify deteriorating patients and trigger appropriate and timely escalation of care. Patients presenting to the emergency department (ED) are undiagnosed, undifferentiated and of varying acuity, yet the effectiveness and cost-effectiveness of using early warning systems and TTS in this setting is unclear. We aimed to systematically review the evidence on the use, development/validation, clinical effectiveness and cost-effectiveness of physiologically based early warning systems and TTS for the detection of deterioration in adult patients presenting to EDs. We searched for any study design in scientific databases and grey literature resources up to March 2016. Two reviewers independently screened results and conducted quality assessment. One reviewer extracted data with independent verification of 50% by a second reviewer. Only information available in English was included. Due to the heterogeneity of reporting across studies, results were synthesised narratively and in evidence tables. We identified 6397 citations of which 47 studies and 1 clinical trial registration were included. Although early warning systems are increasingly used in EDs, compliance varies. One non-randomised controlled trial found that using an early warning system in the ED may lead to a change in patient management but may not reduce adverse events; however, this is uncertain, considering the very low quality of evidence. Twenty-eight different early warning systems were developed/validated in 36 studies. There is relatively good evidence on the predictive ability of certain early warning systems on mortality and ICU/hospital admission. No health economic data were identified. Early warning systems seem to predict adverse outcomes in adult patients of varying acuity presenting to the ED but there is a lack of high quality comparative studies to examine the effect of using early warning systems on patient outcomes. Such studies should include health economics assessments.

Microfluidic System Simulation Including the Electro-Viscous Effect

NASA Technical Reports Server (NTRS)

Rojas, Eileen; Chen, C. P.; Majumdar, Alok

2007-01-01

This paper describes a practical approach using a general purpose lumped-parameter computer program, GFSSP (Generalized Fluid System Simulation Program) for calculating flow distribution in a network of micro-channels including electro-viscous effects due to the existence of electrical double layer (EDL). In this study, an empirical formulation for calculating an effective viscosity of ionic solutions based on dimensional analysis is described to account for surface charge and bulk fluid conductivity, which give rise to electro-viscous effect in microfluidics network. Two dimensional slit micro flow data was used to determine the model coefficients. Geometry effect is then included through a Poiseuille number correlation in GFSSP. The bi-power model was used to calculate flow distribution of isotropically etched straight channel and T-junction microflows involving ionic solutions. Performance of the proposed model is assessed against experimental test data.

Acquisition Management for System of Systems: Affordability through Effective Portfolio Management

DTIC Science & Technology

2013-04-01

the management of strategic “ portfolios of systems” in military acquisitions; this includes application of Real Options (RO) theory and metrics such...Affordability Through Effective Portfolio Management Navindran Davendralingam and Daniel DeLaurentis Purdue University Published April 1, 2013...Systems: Affordability Through Effective Portfolio Management 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

75 FR 39303 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

.... DART. DART is a routing option currently offered by the Exchange in which the entering firm instructs the System to first route to alternative trading systems included in the System routing table. DART... . Please include File No. SR-BATS-2010-017 on the subject line. Paper Comments Send paper comments in...

The Empathic Operating System (emOS)

DTIC Science & Technology

2016-06-15

contextual data, including phone calls, locations, and events, to help mitigate the effects of stress on daily life. This approach offers novel...with their contextual data, including phone calls, locations, and events, to help mitigate the effects of stress on daily life. This approach offers...incorporates users’ physiology with their contextual data, including phone calls, locations, and events, to help mitigate the effects of stress on

Propulsion System Airframe Integration Issues and Aerodynamic Database Development for the Hyper-X Flight Research Vehicle

NASA Technical Reports Server (NTRS)

Engelund, Walter C.; Holland, Scott D.; Cockrell, Charles E., Jr.; Bittner, Robert D.

1999-01-01

NASA's Hyper-X Research Vehicle will provide a unique opportunity to obtain data on an operational airframe integrated scramjet propulsion system at true flight conditions. The airframe integrated nature of the scramjet engine with the Hyper-X vehicle results in a strong coupling effect between the propulsion system operation and the airframe s basic aerodynamic characteristics. Comments on general airframe integrated scramjet propulsion system effects on vehicle aerodynamic performance, stability, and control are provided, followed by examples specific to the Hyper-X research vehicle. An overview is provided of the current activities associated with the development of the Hyper-X aerodynamic database, including wind tunnel test activities and parallel CFD analysis efforts. A brief summary of the Hyper-X aerodynamic characteristics is provided, including the direct and indirect effects of the airframe integrated scramjet propulsion system operation on the basic airframe stability and control characteristics.

A Cooperative Communication System for the Advancement of Safe, Effective, and Efficient Patient Care

DTIC Science & Technology

2017-02-01

for the ever-changing environment of work that must be successfully navigated. The Cooperative Communication System (CCS) is a Health Information...presented a comprehensive picture of the BICU cognitive work , including synchronization on the BICU, the barriers to safe and effective care that...room spared the need to orient participants to an unfamiliar work setting and made it possible to include environmental factors and cues that a

Improving the Effectiveness and Acquisition Management of Selected Weapon Systems: A Summary of Major Issues and Recommended Actions.

DTIC Science & Technology

1982-05-14

need for effective training--a situation which will be impaired until the AH-64 combat mission simulator , now under development, becomes available in...antisubmarine warfare system includes the capability to detect, classify, localize, and destroy the enemy. This capability includes multimillion dollar...to simulate combat situations will simulate only air-to-air activity. Air-to-ground and electronic counter countermeasures simulations were deleted

Effectiveness of panretinal photocoagulation in severe diabetic retinopathy

NASA Astrophysics Data System (ADS)

Astakhov, Yuri S.; Shadrichev, Fedor Y.; Lisochkina, Alla B.

1999-02-01

Diabetic Retinopathy (DR) is one of the most severe complications of diabetes mellitus. In 1994, in St. Petersburg, a new system of ophthalmologic care for diabetic patients was set up. For Russia, this system represents an example of adequate care for subjects with DM, including screening strategies, documentation and education of patients and general ophthalmologists. According to our data, about one half of examined patients had DR, and about 20% of patients were in need of laser treatment. The aim of present study was to evaluate the effectiveness of panretinal photocoagulation (PRP) in cases of severe DR, including advanced nonproliferative DR (preproliferative DR) and proliferative DR. Data concerning 1073 diabetics are included in this study. PRP was performed in 736 cases (1163 eyes). DR stabilization was estimated after one year follow-up PRP enabled preventing severe visual loss in patients with preproliferative DR and proliferative DR. Our system of specialized ophthalmic care for diabetic patients proved to be effective.

The Effectiveness of the Higher Education Quality Assessment System: Problems and Countermeasures in China

ERIC Educational Resources Information Center

Guangli, Zhou

2016-01-01

The effectiveness of the higher education quality assessment system is essentially a matter of policy evaluation. On the macro level, such a system refers to external quality assessment, which includes government evaluation, quality certification, and university rankings. Depending on the degree of government intervention, the external quality…

Coaching as Professional Learning: Guidance for Implementing Effective Coaching Systems

ERIC Educational Resources Information Center

Vermont Agency of Education, 2016

2016-01-01

To build collective capacity within organizations, schools and districts across the world have implemented coaching as an effective method for systemic reform. Vermont in particular has a wide variety of coaches, including instructional coaches and systems coaches, as well as a variety of interpretations of the coaching practice. Many schools…

Models and techniques for evaluating the effectiveness of aircraft computing systems

NASA Technical Reports Server (NTRS)

Meyer, J. F.

1978-01-01

Progress in the development of system models and techniques for the formulation and evaluation of aircraft computer system effectiveness is reported. Topics covered include: analysis of functional dependence: a prototype software package, METAPHOR, developed to aid the evaluation of performability; and a comprehensive performability modeling and evaluation exercise involving the SIFT computer.

Cost-effectiveness of a complex workplace dietary intervention: an economic evaluation of the Food Choice at Work study

PubMed Central

Fitzgerald, Sarah; Murphy, Aileen; Kirby, Ann; Geaney, Fiona; Perry, Ivan J

2018-01-01

Objective To evaluate the costs, benefits and cost-effectiveness of complex workplace dietary interventions, involving nutrition education and system-level dietary modification, from the perspective of healthcare providers and employers. Design Single-study economic evaluation of a cluster-controlled trial (Food Choice at Work (FCW) study) with 1-year follow-up. Setting Four multinational manufacturing workplaces in Cork, Ireland. Participants 517 randomly selected employees (18–65 years) from four workplaces. Interventions Cost data were obtained from the FCW study. Nutrition education included individual nutrition consultations, nutrition information (traffic light menu labelling, posters, leaflets and emails) and presentations. System-level dietary modification included menu modification (restriction of fat, sugar and salt), increase in fibre, fruit discounts, strategic positioning of healthier alternatives and portion size control. The combined intervention included nutrition education and system-level dietary modification. No intervention was implemented in the control. Outcomes The primary outcome was an improvement in health-related quality of life, measured using the EuroQoL 5 Dimensions 5 Levels questionnaire. The secondary outcome measure was reduction in absenteeism, which is measured in monetary amounts. Probabilistic sensitivity analysis (Monte Carlo simulation) assessed parameter uncertainty. Results The system-level intervention dominated the education and combined interventions. When compared with the control, the incremental cost-effectiveness ratio (€101.37/quality-adjusted life-year) is less than the nationally accepted ceiling ratio, so the system-level intervention can be considered cost-effective. The cost-effectiveness acceptability curve indicates there is some decision uncertainty surrounding this, arising from uncertainty surrounding the differences in effectiveness. These results are reiterated when the secondary outcome measure is considered in a cost–benefit analysis, whereby the system-level intervention yields the highest net benefit (€56.56 per employee). Conclusions System-level dietary modification alone offers the most value per improving employee health-related quality of life and generating net benefit for employers by reducing absenteeism. While system-level dietary modification strategies are potentially sustainable obesity prevention interventions, future research should include long-term outcomes to determine if improvements in outcomes persist. Trial registration number ISRCTN35108237; Post-results. PMID:29502090

NASA Project Constellation Systems Engineering Approach

NASA Technical Reports Server (NTRS)

Dumbacher, Daniel L.

2005-01-01

NASA's Office of Exploration Systems (OExS) is organized to empower the Vision for Space Exploration with transportation systems that result in achievable, affordable, and sustainable human and robotic journeys to the Moon, Mars, and beyond. In the process of delivering these capabilities, the systems engineering function is key to implementing policies, managing mission requirements, and ensuring technical integration and verification of hardware and support systems in a timely, cost-effective manner. The OExS Development Programs Division includes three main areas: (1) human and robotic technology, (2) Project Prometheus for nuclear propulsion development, and (3) Constellation Systems for space transportation systems development, including a Crew Exploration Vehicle (CEV). Constellation Systems include Earth-to-orbit, in-space, and surface transportation systems; maintenance and science instrumentation; and robotic investigators and assistants. In parallel with development of the CEV, robotic explorers will serve as trailblazers to reduce the risk and costs of future human operations on the Moon, as well as missions to other destinations, including Mars. Additional information is included in the original extended abstract.

Aircraft Research and Technology for Future Fuels

NASA Technical Reports Server (NTRS)

1980-01-01

The potential characteristics of future aviation turbine fuels and the property effects of these fuels on propulsion system components are examined. The topics that are discussed include jet fuel supply and demand trends, the effects of refining variables on fuel properties, shekle oil processing, the characteristics of broadened property fuels, the effects of fuel property variations on combustor and fuel system performance, and combuster and fuel system technology for broadened property fuels.

Chemistry, Pharmacology, and Toxicology of Khat (Catha Edulis Forsk): A Review

PubMed Central

Wabe, Nasir Tajure

2011-01-01

Catha edulis (khat) is a plant grown commonly in the horn of Africa. The leaves of khat are chewed by the people for its stimulant action. Its young buds and tender leaves are chewed to attain a state of euphoria and stimulation. Khat is an evergreen shrub, which is cultivated as a bush or small tree. The leaves have an aromatic odor. The taste is astringent and slightly sweet. The plant is seedless and hardy, growing in a variety of climates and soils. Many different compounds are found in khat including alkaloids, terpenoids, flavonoids, sterols, glycosides, tannins, amino acids, vitamins and minerals. The phenylalkylamines and the cathedulins are the major alkaloids which are structurally related to amphetamine. The major effects of khat include those on the gastro-intestinal system and on the nervous system. Constipation, urine retention and acute cardiovascular effects may be regarded as autonomic (peripheral) nervous system effects; increased alertness, dependence, tolerance and psychiatric symptoms as effects on the central nervous system. The main toxic effects include increased blood pressure, tachycardia, insomnia, anorexia, constipation, general malaise, irritability, migraine and impaired sexual potency in men. Databases such as Pubmed, Medline, Hinary, Google search, Cochrane and Embase were systematically searched for literature on the different aspects of khat to summarize chemistry, pharmacology, toxicology of khat (Catha edulis Forsk). PMID:24494129

A Simple Demonstration of Convective Effects on Reaction-Diffusion Systems: A Burning Cigarette.

ERIC Educational Resources Information Center

Pojman, John A.

1990-01-01

Described is a demonstration that provides an introduction to nonequilibrium reaction-diffusion systems and the coupling of hydrodynamics to chemical reactions. Experiments that demonstrate autocatalytic behavior that are effected by gravity and convection are included. (KR)

76 FR 34886 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... information technology (IT) supplies, services and systems with security requirements. DATES: Effective Date... effective date that include information technology (IT) supplies, services and systems with security...

Covariant effective action for a Galilean invariant quantum Hall system

DOE PAGES

Geracie, Michael; Prabhu, Kartik; Roberts, Matthew M.

2016-09-16

Here, we construct effective field theories for gapped quantum Hall systems coupled to background geometries with local Galilean invariance i.e. Bargmann spacetimes. Along with an electromagnetic field, these backgrounds include the effects of curved Galilean spacetimes, including torsion and a gravitational field, allowing us to study charge, energy, stress and mass currents within a unified framework. A shift symmetry specific to single constituent theories constraints the effective action to couple to an effective background gauge field and spin connection that is solved for by a self-consistent equation, providing a manifestly covariant extension of Hoyos and Son’s improvement terms to arbitrarymore » order in m.« less

The effect of system nonlinearities on system noise statistics

NASA Technical Reports Server (NTRS)

Robinson, L. H., Jr.

1971-01-01

The effects are studied of nonlinearities in a baseline communications system on the system noise amplitude statistics. So that a meaningful identification of system nonlinearities can be made, the baseline system is assumed to transmit a single biphase-modulated signal through a relay satellite to the receiving equipment. The significant nonlinearities thus identified include square-law or product devices (e.g., in the carrier reference recovery loops in the receivers), bandpass limiters, and traveling wave tube amplifiers.

Annual Conference on Nuclear and Space Radiation Effects, 17th, Cornell University, Ithaca, N.Y., July 15-18, 1980, Proceedings

NASA Technical Reports Server (NTRS)

Mcgarrity, J. M.

1980-01-01

The conference covered the radiation effects on devices, circuits, and systems, physics and basic radiation effects in materials, dosimetry and radiation transport, spacecraft charging, and space radiation effects. Other subjects included single particle upset phenomena, systems-generated electromagnetic pulse phenomena, fabrication of hardened components, testing techniques, and hardness assurance.

Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects

PubMed Central

Sprung, Carl N.; Ivashkevich, Alesia; Forrester, Helen B.; Redon, Christophe E.; Georgakilas, Alexandros; Martin, Olga A.

2013-01-01

A spectrum of radiation-induced non-targeted effects has been reported during the last two decades since Nagasawa and Little first described a phenomenon in cultured cells that was later called the “bystander effect”. These non-targeted effects include radiotherapy-related abscopal effects, where changes in organs or tissues occur distant from the irradiated region. The spectrum of non-targeted effects continue to broaden over time and now embrace many types of exogenous and endogenous stressors that induce a systemic genotoxic response including a widely studied tumor microenvironment. Here we discuss processes and factors leading to DNA damage induction in non-targeted cells and tissues and highlight similarities in the regulation of systemic effects caused by different stressors. PMID:24041866

Employment of Command and Control Systems within the U.S. Marine Corps

ERIC Educational Resources Information Center

Lang, Aaron B.

2012-01-01

The purpose of this study was to identify potential barriers to the effective employment of command and control (C2) systems to enhance warfighter readiness. Five research hypotheses guided this study, which addressed the perception of the effective employment of Marine Corps C2 systems based on demographic characteristics, which included:…

Resource depletion promotes automatic processing: implications for distribution of practice.

PubMed

Scheel, Matthew H

2010-12-01

Recent models of cognition include two processing systems: an automatic system that relies on associative learning, intuition, and heuristics, and a controlled system that relies on deliberate consideration. Automatic processing requires fewer resources and is more likely when resources are depleted. This study showed that prolonged practice on a resource-depleting mental arithmetic task promoted automatic processing on a subsequent problem-solving task, as evidenced by faster responding and more errors. Distribution of practice effects (0, 60, 120, or 180 sec. between problems) on rigidity also disappeared when groups had equal time on resource-depleting tasks. These results suggest that distribution of practice effects is reducible to resource availability. The discussion includes implications for interpreting discrepancies in the traditional distribution of practice effect.

Multi-disciplinary coupling effects for integrated design of propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1993-01-01

Effective computational simulation procedures are described for modeling the inherent multi-disciplinary interactions which govern the accurate response of propulsion systems. Results are presented for propulsion system responses including multi-disciplinary coupling effects using coupled multi-discipline thermal, structural, and acoustic tailoring; an integrated system of multi-disciplinary simulators; coupled material behavior/fabrication process tailoring; sensitivities using a probabilistic simulator; and coupled materials, structures, fracture, and probabilistic behavior simulator. The results demonstrate that superior designs can be achieved if the analysis/tailoring methods account for the multi-disciplinary coupling effects. The coupling across disciplines can be used to develop an integrated coupled multi-discipline numerical propulsion system simulator.

Effects of environmental chemicals on fish thyroid function: Implications for fisheries and aquaculture in Australia.

PubMed

Nugegoda, Dayanthi; Kibria, Golam

2017-04-01

Numerous environmental stressors exert acute or chronic effects on the fish thyroid cascade. Such effects could be mediated via thyroidal alterations, imbalance of plasma T4 and T3 levels or damage to the structure of the thyroidal tissues (thyroid hypertrophy, hyperplasia). The thyroidal system is intricately linked to other endocrine systems in vertebrates including the control of reproduction. Disruption of fish thyroid function by environmental stressors has the potential to result in deleterious effects including the inhibition of sperm production, reduction in egg production, gonad development, ovarian growth, swimming activity, fertilisation and increase in larval mortality. Thyroid hormones play a major role in the development and growth of fish, particularly during their early life stages, thus, thyroid disruption by environmental stressors could inhibit the growth of fish larvae and juveniles in wild fish and cultured species, limit fish seed production and result in a decline in wild fisheries. This review highlights the effects of several environmental toxicants including PBDE, PCBs, PCDD and PCDF, PAH/oil, phthalates, metals, pesticides, mixed pollutants/chemicals, cyanide; and other stressors including acid (low pH) and ammonia, on fish thyroid function. Environmental sources of chemical stressors and appropriate water quality guidelines to protect the freshwater and marine species for the relevant pollutants are also discussed including (when available) the Australian guidelines (2000) and Canadian water quality guidelines (where Australian guidelines are not available). To date there has been no published research on the effects of anthropogenic environmental pollutants on the thyroid system of any native Australian fish species. However, the detection of high risk chemicals (notably PBDEs, PCBs, PAHs, metals and pesticides) in Australian waterways and Australian fish and shellfish implies that thyroid disruption of Australian wild fish and aquacultured species could occur. It is therefore imperative that the effects of such pollutants on the thyroid system of Australian native fish be investigated. Copyright © 2016 Elsevier Inc. All rights reserved.

Neonatal Immunization: Rationale, Current State, and Future Prospects.

PubMed

Whittaker, Elizabeth; Goldblatt, David; McIntyre, Peter; Levy, Ofer

2018-01-01

Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a distinct neonatal immune system that is generally polarized against Th1 responses to many stimuli such that some vaccines that are effective in adults are not in newborns. Nevertheless, neonatal immunization could result in high-population penetration as birth is a reliable point of healthcare contact, and offers an opportunity for early protection of the young, including preterm newborns who are deficient in maternal antibodies. Despite distinct immunity and reduced responses to some vaccines, several vaccines have proven safe and effective at birth. While some vaccines such as polysaccharide vaccines have little effectiveness at birth, hepatitis B vaccine can prime at birth and requires multiple doses to achieve protection, whereas the live-attenuated Bacille Calmette-Guérin (BCG), may offer single shot protection, potentially in part via heterologous ("non-specific") beneficial effects. Additional vaccines have been studied at birth including those directed against pertussis, pneumococcus, Haemophilus influenza type B and rotavirus providing important lessons. Current areas of research in neonatal vaccinology include characterization of early life immune ontogeny, heterogeneity in and heterologous effects of BCG vaccine formulations, applying systems biology and systems serology, in vitro platforms that model age-specific human immunity and discovery and development of novel age-specific adjuvantation systems. These approaches may inform, de-risk, and accelerate development of novel vaccines for use in early life. Key stakeholders, including the general public, should be engaged in assessing the opportunities and challenges inherent to neonatal immunization.

Neonatal Immunization: Rationale, Current State, and Future Prospects

PubMed Central

Whittaker, Elizabeth; Goldblatt, David; McIntyre, Peter; Levy, Ofer

2018-01-01

Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a distinct neonatal immune system that is generally polarized against Th1 responses to many stimuli such that some vaccines that are effective in adults are not in newborns. Nevertheless, neonatal immunization could result in high-population penetration as birth is a reliable point of healthcare contact, and offers an opportunity for early protection of the young, including preterm newborns who are deficient in maternal antibodies. Despite distinct immunity and reduced responses to some vaccines, several vaccines have proven safe and effective at birth. While some vaccines such as polysaccharide vaccines have little effectiveness at birth, hepatitis B vaccine can prime at birth and requires multiple doses to achieve protection, whereas the live-attenuated Bacille Calmette–Guérin (BCG), may offer single shot protection, potentially in part via heterologous (“non-specific”) beneficial effects. Additional vaccines have been studied at birth including those directed against pertussis, pneumococcus, Haemophilus influenza type B and rotavirus providing important lessons. Current areas of research in neonatal vaccinology include characterization of early life immune ontogeny, heterogeneity in and heterologous effects of BCG vaccine formulations, applying systems biology and systems serology, in vitro platforms that model age-specific human immunity and discovery and development of novel age-specific adjuvantation systems. These approaches may inform, de-risk, and accelerate development of novel vaccines for use in early life. Key stakeholders, including the general public, should be engaged in assessing the opportunities and challenges inherent to neonatal immunization. PMID:29670610

C3 generic workstation: Performance metrics and applications

NASA Technical Reports Server (NTRS)

Eddy, Douglas R.

1988-01-01

The large number of integrated dependent measures available on a command, control, and communications (C3) generic workstation under development are described. In this system, embedded communications tasks will manipulate workload to assess the effects of performance-enhancing drugs (sleep aids and decongestants), work/rest cycles, biocybernetics, and decision support systems on performance. Task performance accuracy and latency will be event coded for correlation with other measures of voice stress and physiological functioning. Sessions will be videotaped to score non-verbal communications. Physiological recordings include spectral analysis of EEG, ECG, vagal tone, and EOG. Subjective measurements include SWAT, fatigue, POMS and specialized self-report scales. The system will be used primarily to evaluate the effects on performance of drugs, work/rest cycles, and biocybernetic concepts. Performance assessment algorithms will also be developed, including those used with small teams. This system provides a tool for integrating and synchronizing behavioral and psychophysiological measures in a complex decision-making environment.

Mental health treatment teams and leadership: a systems model.

PubMed

Yank, G R; Barber, J W; Spradlin, W W

1994-10-01

Mental health treatment teams are living systems at the group level and comprise key productive subsystems of organizations providing mental health care. Effective treatment teams, like effective organizations, are anticipatory systems that contain subsystems that model and predict future system and environmental conditions and enable responses that increase system viability. A systems analysis of treatment teams highlights their potential instability due to their tendencies to regress toward dysfunctional partial systems and their active maintenance in nonequilibrium steady states with their organizational and external environments. Team subsystems are analyzed from the viewpoints of system processes and also with regard to individuals and their roles. Boundary processes are central to effective team functioning, assure constancy of team membership, and regulate the team's interfaces with its parent agency and with the external environment. Various causes and forms of disturbed information processing within hierarchical organizations are examined, and their effects at the treatment team level are discussed. The conclusion of the discussion focuses on team leadership and how leadership expands upon the concept of the decider subsystem to include role and personal factors to the team's leaders, and functions that are anticipatory and integrative in nature. Effective leaders must set appropriate thresholds for feedback regulation processes, and balance several pairs of seemingly opposing forces, including homeostasis and development, role differentiation and role overlap, and personal accountability and empowerment of others.

Developing Information Systems for Competitive Intelligence Support.

ERIC Educational Resources Information Center

Hohhof, Bonnie

1994-01-01

Discusses issues connected with developing information systems for competitive intelligence support; defines the elements of an effective competitive information system; and summarizes issues affecting system design and implementation. Highlights include intelligence information; information needs; information sources; decision making; and…

Effects of environmental pollutants on the reproduction and welfare of ruminants

PubMed Central

Rhind, S. M.; Evans, N. P.; Bellingham, M.; Sharpe, R. M.; Cotinot, C.; Mandon-Pepin, B.; Loup, B.; Sinclair, K. D.; Lea, R. G.; Pocar, P.; Fischer, B.; van der Zalm, E.; Hart, K.; Schmidt, J.-S.; Amezaga, M. R.; Fowler, P. A.

2010-01-01

Anthropogenic pollutants comprise a wide range of synthetic organic compounds and heavy metals, which are dispersed throughout the environment, usually at low concentrations. Exposure of ruminants, as for all other animals, is unavoidable and while the levels of exposure to most chemicals are usually too low to induce any physiological effects, combinations of pollutants can act additively or synergistically to perturb multiple physiological systems at all ages but particularly in the developing foetus. In sheep, organs affected by pollutant exposure include the ovary, testis, hypothalamus and pituitary gland and bone. Reported effects of exposure include changes in organ weight and gross structure, histology and gene and protein expression but these changes are not reflected in changes in reproductive performance under the conditions tested. These results illustrate the complexity of the effects of endocrine disrupting compounds on the reproductive axis, which make it difficult to extrapolate between, or even within, species. Effects of pollutant exposure on the thyroid gland, immune, cardiovascular and obesogenic systems have not been shown explicitly, in ruminants, but work on other species suggests that these systems can also be perturbed. It is concluded that exposure to a mixture of anthropogenic pollutants has significant effects on a wide variety of physiological systems, including the reproductive system. Although this physiological insult has not yet been shown to lead to a reduction in ruminant gross performance, there are already reports indicating that anthropogenic pollutant exposure can compromise several physiological systems and may pose a significant threat to both reproductive performance and welfare in the longer term. At present, many potential mechanisms of action for individual chemicals have been identified but knowledge of factors affecting the rate of tissue exposure and of the effects of combinations of chemicals on physiological systems is poor. Nevertheless, both are vital for the identification of risks to animal productivity and welfare. PMID:20582145

Effect of Nutrient Management Planning on Crop Yield, Nitrate Leaching and Sediment Loading in Thomas Brook Watershed

NASA Astrophysics Data System (ADS)

Amon-Armah, Frederick; Yiridoe, Emmanuel K.; Ahmad, Nafees H. M.; Hebb, Dale; Jamieson, Rob; Burton, David; Madani, Ali

2013-11-01

Government priorities on provincial Nutrient Management Planning (NMP) programs include improving the program effectiveness for environmental quality protection, and promoting more widespread adoption. Understanding the effect of NMP on both crop yield and key water-quality parameters in agricultural watersheds requires a comprehensive evaluation that takes into consideration important NMP attributes and location-specific farming conditions. This study applied the Soil and Water Assessment Tool (SWAT) to investigate the effects of crop and rotation sequence, tillage type, and nutrient N application rate on crop yield and the associated groundwater leaching and sediment loss. The SWAT model was applied to the Thomas Brook Watershed, located in the most intensively managed agricultural region of Nova Scotia, Canada. Cropping systems evaluated included seven fertilizer application rates and two tillage systems (i.e., conventional tillage and no-till). The analysis reflected cropping systems commonly managed by farmers in the Annapolis Valley region, including grain corn-based and potato-based cropping systems, and a vegetable-horticulture system. ANOVA models were developed and used to assess the effects of crop management choices on crop yield and two water-quality parameters (i.e., leaching and sediment loading). Results suggest that existing recommended N-fertilizer rate can be reduced by 10-25 %, for grain crop production, to significantly lower leaching ( P > 0.05) while optimizing the crop yield. The analysis identified the nutrient N rates in combination with specific crops and rotation systems that can be used to manage leaching while balancing impacts on crop yields within the watershed.

Space Environmental Effects Testing Capability at the Marshall Space Flight Center

NASA Technical Reports Server (NTRS)

DeWittBurns, H.; Craven, Paul; Finckenor, Miria; Nehls, Mary; Schneider, Todd; Vaughn, Jason

2012-01-01

Understanding the effects of the space environment on materials and systems is fundamental and essential for mission success. If not properly understood and designed for, the effects of the environment can lead to degradation of materials, reduction of functional lifetime, and system failure. In response to this need, the Marshall Space Flight Center has developed world class Space Environmental Effects (SEE) expertise and test facilities to simulate the space environment. Capabilities include multiple unique test systems comprising the most complete SEE testing capability available. These test capabilities include charged particle radiation (electrons, protons, ions), ultraviolet radiation (UV), vacuum ultraviolet radiation (VUV), atomic oxygen, plasma effects, space craft charging, lunar surface and planetary effects, vacuum effects, and hypervelocity impacts as well as the combination of these capabilities. In addition to the uniqueness of the individual test capabilities, MSFC is the only NASA facility where the effects of the different space environments can be tested in one location. Combined with additional analytical capabilities for pre- and post-test evaluation, MSFC is a one-stop shop for materials testing and analysis. The SEE testing and analysis are performed by a team of award winning experts nationally recognized for their contributions in the study of the effects of the space environment on materials and systems. With this broad expertise in space environmental effects and the variety of test systems and equipment available, MSFC is able to customize tests with a demonstrated ability to rapidly adapt and reconfigure systems to meet customers needs. Extensive flight experiment experience bolsters this simulation and analysis capability with a comprehensive understanding of space environmental effects.

Effects of the space flight environment on the immune system

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald; Butel, Janet S.; Shearer, William T.

2003-01-01

Space flight conditions have a dramatic effect on a variety of physiologic functions of mammals, including muscle, bone, and neurovestibular function. Among the physiological functions that are affected when humans or animals are exposed to space flight conditions is the immune response. The focus of this review is on the function of the immune system in space flight conditions during actual space flights, as well as in models of space flight conditions on the earth. The experiments were carried out in tissue culture systems, in animal models, and in human subjects. The results indicate that space flight conditions alter cell-mediated immune responses, including lymphocyte proliferation and subset distribution, and cytokine production. The mechanism(s) of space flight-induced alterations in immune system function remain(s) to be established. It is likely, however, that multiple factors, including microgravity, stress, neuroendocrine factors, sleep disruption, and nutritional factors, are involved in altering certain functions of the immune system. Such alterations could lead to compromised defenses against infections and tumors.

40 CFR 1508.8 - Effects.

Code of Federal Regulations, 2010 CFR

2010-07-01

... related effects on air and water and other natural systems, including ecosystems. Effects and impacts as... resources and on the components, structures, and functioning of affected ecosystems), aesthetic, historic...

40 CFR 1508.8 - Effects.

Code of Federal Regulations, 2013 CFR

2013-07-01

... related effects on air and water and other natural systems, including ecosystems. Effects and impacts as... resources and on the components, structures, and functioning of affected ecosystems), aesthetic, historic...

40 CFR 1508.8 - Effects.

Code of Federal Regulations, 2011 CFR

2011-07-01

... related effects on air and water and other natural systems, including ecosystems. Effects and impacts as... resources and on the components, structures, and functioning of affected ecosystems), aesthetic, historic...

40 CFR 1508.8 - Effects.

Code of Federal Regulations, 2014 CFR

2014-07-01

... related effects on air and water and other natural systems, including ecosystems. Effects and impacts as... resources and on the components, structures, and functioning of affected ecosystems), aesthetic, historic...

40 CFR 1508.8 - Effects.

Code of Federal Regulations, 2012 CFR

2012-07-01

... related effects on air and water and other natural systems, including ecosystems. Effects and impacts as... resources and on the components, structures, and functioning of affected ecosystems), aesthetic, historic...

The MOD-OA 200 kilowatt wind turbine generator design and analysis report

NASA Astrophysics Data System (ADS)

Andersen, T. S.; Bodenschatz, C. A.; Eggers, A. G.; Hughes, P. S.; Lampe, R. F.; Lipner, M. H.; Schornhorst, J. R.

1980-08-01

The project requirements, approach, system description, design requirements, design, analysis, system tests, installation safety considerations, failure modes and effects analysis, data acquisition, and initial performance for the MOD-OA 200 kw wind turbine generator are discussed. The components, the rotor, driven train, nacelle equipment, yaw drive mechanism and brake, tower, foundation, electrical system, and control systems are presented. The rotor includes the blades, hub and pitch change mechanism. The drive train includes the low speed shaft, speed increaser, high speed shaft, and rotor brake. The electrical system includes the generator, switchgear, transformer, and utility connection. The control systems are the blade pitch, yaw, and generator control, and the safety system. Manual, automatic, and remote control and Dynamic loads and fatigue are analyzed.

The MOD-OA 200 kilowatt wind turbine generator design and analysis report

NASA Technical Reports Server (NTRS)

Andersen, T. S.; Bodenschatz, C. A.; Eggers, A. G.; Hughes, P. S.; Lampe, R. F.; Lipner, M. H.; Schornhorst, J. R.

1980-01-01

The project requirements, approach, system description, design requirements, design, analysis, system tests, installation safety considerations, failure modes and effects analysis, data acquisition, and initial performance for the MOD-OA 200 kw wind turbine generator are discussed. The components, the rotor, driven train, nacelle equipment, yaw drive mechanism and brake, tower, foundation, electrical system, and control systems are presented. The rotor includes the blades, hub and pitch change mechanism. The drive train includes the low speed shaft, speed increaser, high speed shaft, and rotor brake. The electrical system includes the generator, switchgear, transformer, and utility connection. The control systems are the blade pitch, yaw, and generator control, and the safety system. Manual, automatic, and remote control and Dynamic loads and fatigue are analyzed.

Effects of graphite nanoparticles on nitrification in an activated sludge system.

PubMed

Dong, Qian; Liu, Yanchen; Shi, Hanchang; Huang, Xia

2017-09-01

Graphite nanoparticles (GNPs) might result in unexpected effects during their transportation and transformation in wastewater treatment systems, including strong thermo-catalytic and catalytic effects and microbial cytotoxicity. In particular, the effects of GNPs on the nitrification process in activated sludge systems should be addressed. This study aimed to estimate the influence of GNPs on the nitrification process in a short-term nitrification reactor with exposure to different light sources. The results indicated that GNPs could only improve the efficiency of photothermal transformation slightly in the activated sludge system because of its photothermal effects under the standard illuminant (imitating 1 × sun). However, even with better photothermal effects, the nitrification efficiency still decreased significantly with GNP dosing under the standard illuminant, which might result from stronger cytotoxic effects of GNPs on the nitrifying bacteria. The disappearance of extracellular polymeric substances (EPS) around bacterial cells was observed, and the total quantity of viable bacteria decreased significantly after GNP exposuring. Variation in bacterial groups primarily occurred in nitrifying microbial communities, including Nitrosomonas sp., Nitrosospira sp., Comamonas sp. and Bradyrhizobiace sp. Nitrifiers significantly decreased, while the phyla Gammaproteobacteria, Deinocccus, and Bacteroidetes exhibited greater stability during GNP treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

SIMULTANEOUS DIFFERENTIAL EQUATION COMPUTER

DOEpatents

Collier, D.M.; Meeks, L.A.; Palmer, J.P.

1960-05-10

A description is given for an electronic simulator for a system of simultaneous differential equations, including nonlinear equations. As a specific example, a homogeneous nuclear reactor system including a reactor fluid, heat exchanger, and a steam boiler may be simulated, with the nonlinearity resulting from a consideration of temperature effects taken into account. The simulator includes three operational amplifiers, a multiplier, appropriate potential sources, and interconnecting R-C networks.

Spacecraft crew procedures from paper to computers

NASA Technical Reports Server (NTRS)

Oneal, Michael; Manahan, Meera

1991-01-01

Described here is a research project that uses human factors and computer systems knowledge to explore and help guide the design and creation of an effective Human-Computer Interface (HCI) for spacecraft crew procedures. By having a computer system behind the user interface, it is possible to have increased procedure automation, related system monitoring, and personalized annotation and help facilities. The research project includes the development of computer-based procedure system HCI prototypes and a testbed for experiments that measure the effectiveness of HCI alternatives in order to make design recommendations. The testbed will include a system for procedure authoring, editing, training, and execution. Progress on developing HCI prototypes for a middeck experiment performed on Space Shuttle Mission STS-34 and for upcoming medical experiments are discussed. The status of the experimental testbed is also discussed.

Uptake and effectiveness of systemic insecticides as influenced by application technique

USDA-ARS?s Scientific Manuscript database

The use of systemic neonicotinoid insecticides such as Imidacloprid and Thiamethoxam have been shown to be effective against different types of insects including sucking insect like aphids, whiteflies, scales and mealybugs. The most common forms of application of these neonicotinoid insecticides ha...

Stretching the Stress Boundary: Linking Air Pollution Health Effects to a Neurohormonal Stress Response

EPA Science Inventory

Inhaled pollutants produce effects in virtually all organ systems in our body and have been linked to chronic diseases including hypertension, atherosclerosis, Alzheimer’s and diabetes. A neurohormonal stress response (referred here as a systemic response produced by activation ...

Non-linear optics of ultrastrongly coupled cavity polaritons

NASA Astrophysics Data System (ADS)

Crescimanno, Michael; Liu, Bin; McMaster, Michael; Singer, Kenneth

2016-05-01

Experiments at CWRU have developed organic cavity polaritons that display world-record vacuum Rabi splittings of more than an eV. This ultrastrongly coupled polaritonic matter is a new regime for exploring non-linear optical effects. We apply quantum optics theory to quantitatively determine various non-linear optical effects including types of low harmonic generation (SHG and THG) in single and double cavity polariton systems. Ultrastrongly coupled photon-matter systems such as these may be the foundation for technologies including low-power optical switching and computing.

Overview of HPM Effects in Electronics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holloway, Michael A.

2012-06-04

The following presentation contains an overview of HPM effects in modern electronics. HPM effects can be categorized into two basic level of effects, which are damaging and non-damaging. Damaging effects include junction breakdowns, dielectric breakdowns, and latch-up. These types of effects render a system inoperable until repaired. With non-damaging effects, HPM signals couple to into system components generating circuit responses that can overwhelm normal operation. Non-damaging effects can temporarily render a system inoperable or cause a system to lock and require a restart. Since modern systems are so complex, fundamental mechanisms of upset in circuit primitives are studied. All topicsmore » covered and all figured contained within are found in open literature. All data plots presented were obtained from experimental measurements conducted at the University of Maryland College Park and are also found in the open literature.« less

Learning the organization: a model for health system analysis for new nurse administrators.

PubMed

Clark, Mary Jo

2004-01-01

Health systems are large and complex organizations in which multiple components and processes influence system outcomes. In order to effectively position themselves in such organizations, nurse administrators new to a system must gain a rapid understanding of overall system operation. Such understanding is facilitated by use of a model for system analysis. The model presented here examines the dynamic interrelationships between and among internal and external elements as they affect system performance. External elements to be analyzed include environmental factors and characteristics of system clientele. Internal elements flow from the mission and goals of the system and include system culture, services, resources, and outcomes.

Revised Simulation Model of the Control System, Displays, and Propulsion System for a ASTOVL Lift Fan Aircraft

NASA Technical Reports Server (NTRS)

Franklin, James A.

1997-01-01

This report describes revisions to a simulation model that was developed for use in piloted evaluations of takeoff, transition, hover, and landing characteristics of an advanced short takeoff and vertical landing lift fan fighter aircraft. These revisions have been made to the flight/propulsion control system, head-up display, and propulsion system to reflect recent flight and simulation experience with short takeoff and vertical landing operations. They include nonlinear inverse control laws in all axes (eliminating earlier versions with state rate feedback), throttle scaling laws for flightpath and thrust command, control selector commands apportioned based on relative effectiveness of the individual controls, lateral guidance algorithms that provide more flexibility for terminal area operations, and a simpler representation of the propulsion system. The model includes modes tailored to the phases of the aircraft's operation, with several response types which are coupled to the aircraft's aerodynamic and propulsion system effectors through a control selector tailored to the propulsion system. Head-up display modes for approach and hover are integrated with the corresponding control modes. Propulsion system components modeled include a remote lift fan and a lift-cruise engine. Their static performance and dynamic responses are represented by the model. A separate report describes the subsonic, power-off aerodynamics and jet induced aerodynamics in hover and forward flight, including ground effects.

Effectiveness of nursing management information systems: a systematic review.

PubMed

Choi, Mona; Yang, You Lee; Lee, Sun-Mi

2014-10-01

The purpose of this study was to review evaluation studies of nursing management information systems (NMISs) and their outcome measures to examine system effectiveness. For the systematic review, a literature search of the PubMed, CINAHL, Embase, and Cochrane Library databases was conducted to retrieve original articles published between 1970 and 2014. Medical Subject Headings (MeSH) terms included informatics, medical informatics, nursing informatics, medical informatics application, and management information systems for information systems and evaluation studies and nursing evaluation research for evaluation research. Additionally, manag(*) and admin(*), and nurs(*) were combined. Title, abstract, and full-text reviews were completed by two reviewers. And then, year, author, type of management system, study purpose, study design, data source, system users, study subjects, and outcomes were extracted from the selected articles. The quality and risk of bias of the studies that were finally selected were assessed with the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS) criteria. Out of the 2,257 retrieved articles, a total of six articles were selected. These included two scheduling programs, two nursing cost-related programs, and two patient care management programs. For the outcome measurements, usefulness, time saving, satisfaction, cost, attitude, usability, data quality/completeness/accuracy, and personnel work patterns were included. User satisfaction, time saving, and usefulness mostly showed positive findings. The study results suggest that NMISs were effective in time saving and useful in nursing care. Because there was a lack of quality in the reviewed studies, well-designed research, such as randomized controlled trials, should be conducted to more objectively evaluate the effectiveness of NMISs.

Cost-Effective CNC Part Program Verification Development for Laboratory Instruction.

ERIC Educational Resources Information Center

Chen, Joseph C.; Chang, Ted C.

2000-01-01

Describes a computer numerical control program verification system that checks a part program before its execution. The system includes character recognition, word recognition, a fuzzy-nets system, and a tool path viewer. (SK)

Reliability program requirements for aeronautical and space system contractors

NASA Technical Reports Server (NTRS)

1987-01-01

General reliability program requirements for NASA contracts involving the design, development, fabrication, test, and/or use of aeronautical and space systems including critical ground support equipment are prescribed. The reliability program requirements require (1) thorough planning and effective management of the reliability effort; (2) definition of the major reliability tasks and their place as an integral part of the design and development process; (3) planning and evaluating the reliability of the system and its elements (including effects of software interfaces) through a program of analysis, review, and test; and (4) timely status indication by formal documentation and other reporting to facilitate control of the reliability program.

Fault-tolerant power distribution system

NASA Technical Reports Server (NTRS)

Volp, Jeffrey A. (Inventor)

1987-01-01

A fault-tolerant power distribution system which includes a plurality of power sources and a plurality of nodes responsive thereto for supplying power to one or more loads associated with each node. Each node includes a plurality of switching circuits, each of which preferably uses a power field effect transistor which provides a diode operation when power is first applied to the nodes and which thereafter provides bi-directional current flow through the switching circuit in a manner such that a low voltage drop is produced in each direction. Each switching circuit includes circuitry for disabling the power field effect transistor when the current in the switching circuit exceeds a preselected value.

42 CFR 493.1299 - Standard: Postanalytic systems quality assessment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Postanalytic systems quality assessment... Nonwaived Testing Postanalytic Systems § 493.1299 Standard: Postanalytic systems quality assessment. (a) The....1291. (b) The postanalytic systems quality assessment must include a review of the effectiveness of...

Identifying Effectiveness Criteria for Internet Payment Systems.

ERIC Educational Resources Information Center

Shon, Tae-Hwan; Swatman, Paula M. C.

1998-01-01

Examines Internet payment systems (IPS): third-party, card, secure Web server, electronic token, financial electronic data interchange (EDI), and micropayment based. Reports the results of a Delphi survey of experts identifying and classifying IPS effectiveness criteria and classifying types of IPS providers. Includes the survey invitation letter…

21 CFR 110.20 - Plant and grounds.

Code of Federal Regulations, 2011 CFR

2011-04-01

... filth, or providing a breeding place for pests. (4) Operating systems for waste treatment and disposal... controls and operating practices or effective design, including the separation of operations in which..., enclosed systems, or other effective means. (3) Permit the taking of proper precautions to protect food in...

21 CFR 110.20 - Plant and grounds.

Code of Federal Regulations, 2014 CFR

2014-04-01

... filth, or providing a breeding place for pests. (4) Operating systems for waste treatment and disposal... controls and operating practices or effective design, including the separation of operations in which..., enclosed systems, or other effective means. (3) Permit the taking of proper precautions to protect food in...

21 CFR 110.20 - Plant and grounds.

Code of Federal Regulations, 2013 CFR

2013-04-01

... filth, or providing a breeding place for pests. (4) Operating systems for waste treatment and disposal... controls and operating practices or effective design, including the separation of operations in which..., enclosed systems, or other effective means. (3) Permit the taking of proper precautions to protect food in...

Model mount system for testing flutter

NASA Technical Reports Server (NTRS)

Farmer, M. G. (Inventor)

1984-01-01

A wind tunnel model mount system is disclosed for effectively and accurately determining the effects of attack and airstream velocity on a model airfoil or aircraft. The model mount system includes a rigid model attached to a splitter plate which is supported away from the wind tunnel wall several of flexible rods. Conventional instrumentation is employed to effect model rotation through a turntable and to record model flutter data as a function of the angle of attack versus dynamic pressure.

Noise analysis for near field 3-D FM-CW radar imaging systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheen, David M.

2015-06-19

Near field radar imaging systems are used for several applications including concealed weapon detection in airports and other high-security venues. Despite the near-field operation, phase noise and thermal noise can limit the performance in several ways including reduction in system sensitivity and reduction of image dynamic range. In this paper, the effects of thermal noise, phase noise, and processing gain are analyzed in the context of a near field 3-D FM-CW imaging radar as might be used for concealed weapon detection. In addition to traditional frequency domain analysis, a time-domain simulation is employed to graphically demonstrate the effect of thesemore » noise sources on a fast-chirping FM-CW system.« less

Effects of microgravity on the immune system

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald; Taylor, Gerald R.

1991-01-01

Changes in resistance to bacterial and viral infections in Apollo crew members has stimulated interest in the study of immunity and space flight. Results of studies from several laboratories in both humans and rodents have indicated alterations after space flight that include the following immunological parameters: thymus size, lymphocyte blastogenesis, interferon and interleukin production, natural killer cell activity, cytotoxic T-cell activity, leukocyte subset population distribution, response of bone marrow cells to colony stimulating factors, and delayed hypersensitivity skin test reactivity. The interactions of the immune system with other physiological systems, including muscle, bone, and the nervous system, may play a major role in the development of these immunological parameters during and after flight. There may also be direct effects of space flight on immune responses.

Path-integral isomorphic Hamiltonian for including nuclear quantum effects in non-adiabatic dynamics

NASA Astrophysics Data System (ADS)

Tao, Xuecheng; Shushkov, Philip; Miller, Thomas F.

2018-03-01

We describe a path-integral approach for including nuclear quantum effects in non-adiabatic chemical dynamics simulations. For a general physical system with multiple electronic energy levels, a corresponding isomorphic Hamiltonian is introduced such that Boltzmann sampling of the isomorphic Hamiltonian with classical nuclear degrees of freedom yields the exact quantum Boltzmann distribution for the original physical system. In the limit of a single electronic energy level, the isomorphic Hamiltonian reduces to the familiar cases of either ring polymer molecular dynamics (RPMD) or centroid molecular dynamics Hamiltonians, depending on the implementation. An advantage of the isomorphic Hamiltonian is that it can easily be combined with existing mixed quantum-classical dynamics methods, such as surface hopping or Ehrenfest dynamics, to enable the simulation of electronically non-adiabatic processes with nuclear quantum effects. We present numerical applications of the isomorphic Hamiltonian to model two- and three-level systems, with encouraging results that include improvement upon a previously reported combination of RPMD with surface hopping in the deep-tunneling regime.

Knowledge-Based Information Retrieval.

ERIC Educational Resources Information Center

Ford, Nigel

1991-01-01

Discussion of information retrieval focuses on theoretical and empirical advances in knowledge-based information retrieval. Topics discussed include the use of natural language for queries; the use of expert systems; intelligent tutoring systems; user modeling; the need for evaluation of system effectiveness; and examples of systems, including…

Green tea extracts reduce leukocyte cell-Derived chemotaxin 2 and selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat diet.

PubMed

Onishi, Shintaro; Kitazawa, Hidefumi; Meguro, Shinichi; Tokimitsu, Ichiro

2018-05-31

Epidemiological studies suggest that green tea extracts (GTEs), including catechins such as epigallocatechin gallate and epicatechin gallate, have a beneficial effect on obesity, hyperglycemia, insulin resistance, endothelial dysfunction, and inflammation. Although several studies have shown that catechins directly modulate the cellular and molecular alterations in the liver tissue, the contributions of indirect mechanisms underlying these systemic effects of catechins remain unclear. In this study, we report that, in the C57BL/6J mouse liver, GTEs reduce high-fat diet-induced increases in the levels of hepatokines, liver-derived secretary proteins such as leukocyte cell-derived chemotaxin 2 and selenoprotein P production, which have been shown to induce systemic adverse effects, including several metabolic diseases. These findings suggest that the systemic effects of GTEs involve the regulation of hepatokine production as an indirect mechanism.

Evaluating the Effect of Integrated System Health Management on Mission Effectiveness

DTIC Science & Technology

2013-03-01

Health Status, Fault Detection , IMS Commands «Needline» 110 B.6 OV-5a « O V -5 » a c t O V -5 [ O V -5 a...UAS to self- detect , isolate, and diagnose system health problems. Current flight avionics architectures may include lower level sub-system health ... monitoring or may isolate health monitoring functions to a black box configuration, but a vehicle-wide health monitoring information system has

24 CFR 1710.111 - Utilities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... system, what are the total estimated costs of the system, including but not limited to, the costs of... productive well cannot be installed, include a statement to the effect that there is no assurance a productive well can be installed and, if it cannot, no refund of the purchase price of the lot will be made...

24 CFR 1710.111 - Utilities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... system, what are the total estimated costs of the system, including but not limited to, the costs of... productive well cannot be installed, include a statement to the effect that there is no assurance a productive well can be installed and, if it cannot, no refund of the purchase price of the lot will be made...

12 CFR 1010.111 - Utilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... other individual system, what are the total estimated costs of the system, including but not limited to... the event a productive well cannot be installed, include a statement to the effect that there is no assurance a productive well can be installed and, if it cannot, no refund of the purchase price of the lot...

12 CFR 1010.111 - Utilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... other individual system, what are the total estimated costs of the system, including but not limited to... the event a productive well cannot be installed, include a statement to the effect that there is no assurance a productive well can be installed and, if it cannot, no refund of the purchase price of the lot...

24 CFR 1710.111 - Utilities.

Code of Federal Regulations, 2013 CFR

2013-04-01

... system, what are the total estimated costs of the system, including but not limited to, the costs of... productive well cannot be installed, include a statement to the effect that there is no assurance a productive well can be installed and, if it cannot, no refund of the purchase price of the lot will be made...

24 CFR 1710.111 - Utilities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... system, what are the total estimated costs of the system, including but not limited to, the costs of... productive well cannot be installed, include a statement to the effect that there is no assurance a productive well can be installed and, if it cannot, no refund of the purchase price of the lot will be made...

12 CFR 1010.111 - Utilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... other individual system, what are the total estimated costs of the system, including but not limited to... the event a productive well cannot be installed, include a statement to the effect that there is no assurance a productive well can be installed and, if it cannot, no refund of the purchase price of the lot...

Investigating Effects of Embedding Collaboration in an Intelligent Tutoring System for Elementary School Students

ERIC Educational Resources Information Center

Olsen, Jennifer K.; Rummel, Nikol; Aleven, Vincent

2016-01-01

Intelligent Tutoring Systems (ITSs) are beneficial for individual students learning in several domains, including mathematics where they have been used to support both secondary and elementary students. Collaborative learning may be beneficial to include in ITSs, particularly for conceptual knowledge. There is little work on collaborative ITSs,…

Inertial Upper Stage (IUS) software analysis

NASA Technical Reports Server (NTRS)

Grayson, W. L.; Nickel, C. E.; Rose, P. L.; Singh, R. P.

1979-01-01

The Inertial Upper Stage (IUS) System, an extension of the Space Transportation System (STS) operating regime to include higher orbits, orbital plane changes, geosynchronous orbits, and interplanetary trajectories is presented. The IUS software design, the IUS software interfaces with other systems, and the cost effectiveness in software verification are described. Tasks of the IUS discussed include: (1) design analysis; (2) validation requirements analysis; (3) interface analysis; and (4) requirements analysis.

Non-ferromagnetic overburden casing

DOEpatents

Vinegar, Harold J.; Harris, Christopher Kelvin; Mason, Stanley Leroy

2010-09-14

Systems, methods, and heaters for treating a subsurface formation are described herein. At least one system for electrically insulating an overburden portion of a heater wellbore is described. The system may include a heater wellbore located in a subsurface formation and an electrically insulating casing located in the overburden portion of the heater wellbore. The casing may include at least one non-ferromagnetic material such that ferromagnetic effects are inhibited in the casing.

From Earth to Orbit: An assessment of transportation options

NASA Technical Reports Server (NTRS)

Gavin, Joseph G., Jr.; Blond, Edmund; Brill, Yvonne C.; Budiansky, Bernard; Cooper, Robert S.; Demisch, Wolfgang H.; Hawk, Clark W.; Kerrebrock, Jack L.; Lichtenberg, Byron K.; Mager, Artur

1992-01-01

The report assesses the requirements, benefits, technological feasibility, and roles of Earth-to-Orbit transportation systems and options that could be developed in support of future national space programs. Transportation requirements, including those for Mission-to-Planet Earth, Space Station Freedom assembly and operation, human exploration of space, space science missions, and other major civil space missions are examined. These requirements are compared with existing, planned, and potential launch capabilities, including expendable launch vehicles (ELV's), the Space Shuttle, the National Launch System (NLS), and new launch options. In addition, the report examines propulsion systems in the context of various launch vehicles. These include the Advanced Solid Rocket Motor (ASRM), the Redesigned Solid Rocket Motor (RSRM), the Solid Rocket Motor Upgrade (SRMU), the Space Shuttle Main Engine (SSME), the Space Transportation Main Engine (STME), existing expendable launch vehicle engines, and liquid-oxygen/hydrocarbon engines. Consideration is given to systems that have been proposed to accomplish the national interests in relatively cost effective ways, with the recognition that safety and reliability contribute to cost-effectiveness. Related resources, including technology, propulsion test facilities, and manufacturing capabilities are also discussed.

Science, education and industry information resources complementarity as a basis for design of knowledge management systems

NASA Astrophysics Data System (ADS)

Maksimov, N. V.; Tikhomirov, G. V.; Golitsyna, O. L.

2017-01-01

The main problems and circumstances that influence the processes of creating effective knowledge management systems were described. These problems particularly include high species diversity of instruments for knowledge representation, lack of adequate lingware, including formal representation of semantic relationships. For semantic data descriptions development a conceptual model of the subject area and a conceptual-lexical system should be designed on proposals of ISO-15926 standard. It is proposed to conduct an information integration of educational and production processes on the basis of information systems technologies. Integrated knowledge management system information environment combines both traditional information resources and specific information resources of subject domain including task context and implicit/tacit knowledge.

Cost-effectiveness of a complex workplace dietary intervention: an economic evaluation of the Food Choice at Work study.

PubMed

Fitzgerald, Sarah; Murphy, Aileen; Kirby, Ann; Geaney, Fiona; Perry, Ivan J

2018-03-03

To evaluate the costs, benefits and cost-effectiveness of complex workplace dietary interventions, involving nutrition education and system-level dietary modification, from the perspective of healthcare providers and employers. Single-study economic evaluation of a cluster-controlled trial (Food Choice at Work (FCW) study) with 1-year follow-up. Four multinational manufacturing workplaces in Cork, Ireland. 517 randomly selected employees (18-65 years) from four workplaces. Cost data were obtained from the FCW study. Nutrition education included individual nutrition consultations, nutrition information (traffic light menu labelling, posters, leaflets and emails) and presentations. System-level dietary modification included menu modification (restriction of fat, sugar and salt), increase in fibre, fruit discounts, strategic positioning of healthier alternatives and portion size control. The combined intervention included nutrition education and system-level dietary modification. No intervention was implemented in the control. The primary outcome was an improvement in health-related quality of life, measured using the EuroQoL 5 Dimensions 5 Levels questionnaire. The secondary outcome measure was reduction in absenteeism, which is measured in monetary amounts. Probabilistic sensitivity analysis (Monte Carlo simulation) assessed parameter uncertainty. The system-level intervention dominated the education and combined interventions. When compared with the control, the incremental cost-effectiveness ratio (€101.37/quality-adjusted life-year) is less than the nationally accepted ceiling ratio, so the system-level intervention can be considered cost-effective. The cost-effectiveness acceptability curve indicates there is some decision uncertainty surrounding this, arising from uncertainty surrounding the differences in effectiveness. These results are reiterated when the secondary outcome measure is considered in a cost-benefit analysis, whereby the system-level intervention yields the highest net benefit (€56.56 per employee). System-level dietary modification alone offers the most value per improving employee health-related quality of life and generating net benefit for employers by reducing absenteeism. While system-level dietary modification strategies are potentially sustainable obesity prevention interventions, future research should include long-term outcomes to determine if improvements in outcomes persist. ISRCTN35108237; Post-results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Chaos in a Fractional Order Chua System

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.; Hartley, Tom T.; Qammar, Helen Killory

1996-01-01

This report studies the effects of fractional dynamics in chaotic systems. In particular, Chua's system is modified to include fractional order elements. Varying the total system order incrementally from 2.6 to 3.7 demonstrates that systems of 'order' less than three can exhibit chaos as well as other nonlinear behavior. This effectively forces a clarification of the definition of order which can no longer be considered only by the total number of differentiations or by the highest power of the Laplace variable.

Economic evaluations of eHealth technologies: A systematic review.

PubMed

Sanyal, Chiranjeev; Stolee, Paul; Juzwishin, Don; Husereau, Don

2018-01-01

Innovations in eHealth technologies have the potential to help older adults live independently, maintain their quality of life, and to reduce their health system dependency and health care expenditure. The objective of this study was to systematically review and appraise the quality of cost-effectiveness or utility studies assessing eHealth technologies in study populations involving older adults. We systematically searched multiple databases (MEDLINE, EMBASE, CINAHL, NHS EED, and PsycINFO) for peer-reviewed studies published in English from 2000 to 2016 that examined cost-effectiveness (or utility) of eHealth technologies. The reporting quality of included studies was appraised using the Consolidated Health Economic Evaluation Reporting Standards statement. Eleven full text articles met the inclusion criteria representing public and private health care systems. eHealth technologies evaluated by these studies includes computerized decision support system, a web-based physical activity intervention, internet-delivered cognitive behavioral therapy, telecare, and telehealth. Overall, the reporting quality of the studies included in the review was varied. Most studies demonstrated efficacy and cost-effectiveness of an intervention using a randomized control trial and statistical modeling, respectively. This review found limited information on the feasibility of adopting these technologies based on economic and organizational factors. This review identified few economic evaluations of eHealth technologies that included older adults. The quality of the current evidence is limited and further research is warranted to clearly demonstrate the long-term cost-effectiveness of eHealth technologies from the health care system and societal perspectives.

Coupling effect and control strategies of the maglev dual-stage inertially stabilization system based on frequency-domain analysis.

PubMed

Lin, Zhuchong; Liu, Kun; Zhang, Li; Zeng, Delin

2016-09-01

Maglev dual-stage inertially stabilization (MDIS) system is a newly proposed system which combines a conventional two-axis gimbal assembly and a 5-DOF (degree of freedom) magnetic bearing with vernier tilting capacity to perform dual-stage stabilization for the LOS of the suspended optical instrument. Compared with traditional dual-stage system, maglev dual-stage system exhibits different characteristics due to the negative position stiffness of the magnetic forces, which introduces additional coupling in the dual stage control system. In this paper, the coupling effect on the system performance is addressed based on frequency-domain analysis, including disturbance rejection, fine stage saturation and coarse stage structural resonance suppression. The difference between various control strategies is also discussed, including pile-up(PU), stabilize-follow (SF) and stabilize-compensate (SC). A number of principles for the design of a maglev dual stage system are proposed. A general process is also suggested, which leads to a cost-effective design striking a balance between high performance and complexity. At last, a simulation example is presented to illustrate the arguments in the paper. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

Evaluation of the overheight detection system effectiveness at Eklutna bridge.

DOT National Transportation Integrated Search

2013-03-01

The Eklutna River/Glenn Highway bridge has sustained repeated impacts from overheight trucks. In 2006, ADOT&PF installed an : overheight vehicle warning system. The system includes laser detectors, alarms, and message boards. Since installation, pers...

The effectiveness of a mail reminder system for depot medroxyprogesterone injections.

PubMed

Madlon-Kay, D J

1996-04-01

To determine if a mail reminder system leads to an increase in the percentage of depot medroxyprogesterone acetate (Depo-Provera) injections administered on time, the charts of 184 women were reviewed. The reminder postcard included the due dates of both the next medroxyprogesterone injection and the next Papanicolaou test. Timeliness of injections improved with the reminder system from 64% administered on time to 76% (P < .02). Injections given late despite the reminders were late a mean of 8 days. Injections given late before the reminder system began were late a mean of 20 days (P < .05). If injections given during the injection's 14-day "grace" period are included, the on-time rate improved from 87% to 96% with the reminder system (P < .005). The reminder system was not effective in ensuring annual Papanicolaou testing. Vigilance is needed to ensure that women receiving medroxyprogesterone injections also receive timely Papanicolaou testing.

Internally insulated thermal storage system development program

NASA Technical Reports Server (NTRS)

Scott, O. L.

1980-01-01

A cost effective thermal storage system for a solar central receiver power system using molten salt stored in internally insulated carbon steel tanks is described. Factors discussed include: testing of internal insulation materials in molten salt; preliminary design of storage tanks, including insulation and liner installation; optimization of the storage configuration; and definition of a subsystem research experiment to demonstrate the system. A thermal analytical model and analysis of a thermocline tank was performed. Data from a present thermocline test tank was compared to gain confidence in the analytical approach. A computer analysis of the various storage system parameters (insulation thickness, number of tanks, tank geometry, etc.,) showed that (1) the most cost-effective configuration was a small number of large cylindrical tanks, and (2) the optimum is set by the mechanical constraints of the system, such as soil bearing strength and tank hoop stress, not by the economics.

Internally insulated thermal storage system development program

NASA Astrophysics Data System (ADS)

Scott, O. L.

1980-03-01

A cost effective thermal storage system for a solar central receiver power system using molten salt stored in internally insulated carbon steel tanks is described. Factors discussed include: testing of internal insulation materials in molten salt; preliminary design of storage tanks, including insulation and liner installation; optimization of the storage configuration; and definition of a subsystem research experiment to demonstrate the system. A thermal analytical model and analysis of a thermocline tank was performed. Data from a present thermocline test tank was compared to gain confidence in the analytical approach. A computer analysis of the various storage system parameters (insulation thickness, number of tanks, tank geometry, etc.,) showed that (1) the most cost-effective configuration was a small number of large cylindrical tanks, and (2) the optimum is set by the mechanical constraints of the system, such as soil bearing strength and tank hoop stress, not by the economics.

10 CFR 600.323 - Property management system.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Property management system. 600.323 Section 600.323 Energy....323 Property management system. The recipient's property management system must include the following... existence, current utilization, and continued need for the property. (d) A control system must be in effect...

10 CFR 600.323 - Property management system.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Property management system. 600.323 Section 600.323 Energy....323 Property management system. The recipient's property management system must include the following... existence, current utilization, and continued need for the property. (d) A control system must be in effect...

42 CFR 493.1289 - Standard: Analytic systems quality assessment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Analytic systems quality assessment. 493... Nonwaived Testing Analytic Systems § 493.1289 Standard: Analytic systems quality assessment. (a) The... through 493.1283. (b) The analytic systems quality assessment must include a review of the effectiveness...

Steam plant startup and control in system restoration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mello, F.P. de; Westcott, J.C.

1994-02-01

The IEEE Working Group on Power System Restoration developed a panel session for the Summer Power Meeting on July 14, 1992 on Special Considerations in Power System Restoration. One of the contributions to this session is presented in this paper dealing with aspects of steam plant startup and control in scenarios of system restoration. The topics addressed include the complexity of a steam plant, the contrast between normal plant startups and shutdowns and those following major system blackouts including the effects of plant design, automatic controls, bypass valving and operator training.

Grapevine pruning systems and cultivars influence the diversity of wood-colonizing fungi

USDA-ARS?s Scientific Manuscript database

Grapevines host diverse fungal species, including pruning-wound pathogens and wood decomposers, with detrimental effects on crop productivity. This study aims at comparing the effects of two pruning systems, minimal (min-) or spur-pruning, on the sanitary status of vine trunks and the diversity of w...

Techno-ecological synergy as a path toward sustainability of a North American residential system.

PubMed

Urban, Robert A; Bakshi, Bhavik R

2013-02-19

For any human-designed system to be sustainable, ecosystem services that support it must be readily available. This work explicitly accounts for this dependence by designing synergies between technological and ecological systems. The resulting techno-ecological network mimics nature at the systems level, can stay within ecological constraints, and can identify novel designs that are economically and environmentally attractive that may not be found by the traditional design focus on technological options. This approach is showcased by designing synergies for a typical American suburban home at local and life cycle scales. The objectives considered are carbon emissions, water withdrawal, and cost savings. Systems included in the design optimization include typical ecosystems in suburban yards: lawn, trees, water reservoirs, and a vegetable garden; technological systems: heating, air conditioning, faucets, solar panels, etc.; and behavioral variables: heating and cooling set points. The ecological and behavioral design variables are found to have a significant effect on the three objectives, in some cases rivaling and exceeding the effect of traditional technological options. These results indicate the importance and benefits of explicitly including ecosystems in the design of sustainable systems, something that is rarely done in existing methods.

State-Level Cancer Quality Assessment and Research

PubMed Central

Lipscomb, Joseph; Gillespie, Theresa W.

2016-01-01

Over a decade ago, the Institute of Medicine called for a national cancer data system in the United States to support quality-of-care assessment and improvement, including research on effective interventions. Although considerable progress has been achieved in cancer quality measurement and effectiveness research, the nation still lacks a population-based data infrastructure for accurately identifying cancer patients and tracking services and outcomes over time. For compelling reasons, the most effective pathway forward may be the development of state-level cancer data systems, in which central registry data are linked to multiple public and private secondary sources. These would include administrative/claims files from Medicare, Medicaid, and private insurers. Moreover, such a state-level system would promote rapid learning by encouraging adoption of near-real-time reporting and feedback systems, such as the Commission on Cancer’s new Rapid Quality Reporting System. The groundwork for such a system is being laid in the state of Georgia, and similar work is advancing in other states. The pace of progress depends on the successful resolution of issues related to the application of information technology, financing, and governance. PMID:21799333

Radiation Effects on Optoelectronic Devices in Space Missions

NASA Technical Reports Server (NTRS)

Johnston, Allan H.

2006-01-01

Radiation degradation of optoelectronic devices is discussed, including effects on optical emitters, detectors and optocouplers. The importance of displacement damage is emphasized, including the limitations of non-ionizing energy loss (NIEL) in normalizing damage. Failures of optoelectronics in fielded space systems are discussed, along with testing and qualification methods.

THE EFFECTS OF RADIATION AND RADIOISOTOPES ON THE LIFE PROCESSES. An Annotated Bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, C.M. comp.

Issued in two books and an Index. A total of 11,944 annotated references is presented to report and published literature concerning the effects of radiation on biological systems. Abstracts are included for many references. Author and subject indexes are included. (C.H.)

The dependence of permeability on effective stress from flow tests at hot dry rock reservoirs at Rosemanowes (Cornwall) and Fenton Hill (New Mexico)

USGS Publications Warehouse

Nathenson, M.

1999-01-01

Effective stress is the primary control on permeability and thus on flow and water loss for two-well hot dry rock systems involving injection and production that have been tested to date. Theoretical relations are derived for the flow between an injector and producer, including the dependence of permeability on effective stress. Four relations for permeability as a function of effective stress are used to match field data for the hot dry rock systems at Rosemanowes, Cornwall, and Fenton Hill, New Mexico. The flow and water loss behavior of these systems are well explained by the influence of effective stress on permeability. All four relations for permeability as a function of effective stress are successful in matching the field data, but some have difficulty in determining unique values for elastic and hydrologic parameters.Effective stress is the primary control on permeability and thus on flow and water loss for two-well hot dry rock systems involving injection and production that have been tested to date. Theoretical relations are derived for the flow between an injector and producer, including the dependence of permeability on effective stress. Four relations for permeability as a function of effective stress are used to match field data for the hot dry rock systems at Rosemanowes, Cornwall, and Fenton Hill, New Mexico. The flow and water loss behavior of these systems are well explained by the influence of effective stress on permeability. All four relations for permeability as a function of effective stress are successful in matching the field data, but some have difficulty in determining unique values for elastic and hydrologic parameters.

Failure Modes Effects and Criticality Analysis, an Underutilized Safety, Reliability, Project Management and Systems Engineering Tool

NASA Astrophysics Data System (ADS)

Mullin, Daniel Richard

2013-09-01

The majority of space programs whether manned or unmanned for science or exploration require that a Failure Modes Effects and Criticality Analysis (FMECA) be performed as part of their safety and reliability activities. This comes as no surprise given that FMECAs have been an integral part of the reliability engineer's toolkit since the 1950s. The reasons for performing a FMECA are well known including fleshing out system single point failures, system hazards and critical components and functions. However, in the author's ten years' experience as a space systems safety and reliability engineer, findings demonstrate that the FMECA is often performed as an afterthought, simply to meet contract deliverable requirements and is often started long after the system requirements allocation and preliminary design have been completed. There are also important qualitative and quantitative components often missing which can provide useful data to all of project stakeholders. These include; probability of occurrence, probability of detection, time to effect and time to detect and, finally, the Risk Priority Number. This is unfortunate as the FMECA is a powerful system design tool that when used effectively, can help optimize system function while minimizing the risk of failure. When performed as early as possible in conjunction with writing the top level system requirements, the FMECA can provide instant feedback on the viability of the requirements while providing a valuable sanity check early in the design process. It can indicate which areas of the system will require redundancy and which areas are inherently the most risky from the onset. Based on historical and practical examples, it is this author's contention that FMECAs are an immense source of important information for all involved stakeholders in a given project and can provide several benefits including, efficient project management with respect to cost and schedule, system engineering and requirements management, assembly integration and test (AI&T) and operations if applied early, performed to completion and updated along with system design.

CRITICAL TESTS FOR PRT REACTOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Triplett, J.R.; Anderson, J.K.; Dunn, R.E.

1960-07-01

Critical teste to be performed on the Plutonium Recycle Te st Heactor are described. Exponential, approach-tocritical, critical, and substitution experiments will be carried out. These experiments include: calibration of moderator level; determination of the wori of various fuel loadings; calibration of the shim system including determination of maximum control strength of the entire system; substitution experiments to determine reflector savings, void effects, effects of H/sub 2/O and degraded D/sub 2/O coolants, and effects of loop and other material intsllations; determination of fuel-plus-coolant and moderator temperature coefficients; and kinetic experiments to determine response of the reactor to reactivity changes. (M.C.G.)

Prediction of rain effects on earth-space communication links operating in the 10 to 35 GHz frequency range

NASA Technical Reports Server (NTRS)

Stutzman, Warren L.

1989-01-01

This paper reviews the effects of precipitation on earth-space communication links operating the 10 to 35 GHz frequency range. Emphasis is on the quantitative prediction of rain attenuation and depolarization. Discussions center on the models developed at Virginia Tech. Comments on other models are included as well as literature references to key works. Also included is the system level modeling for dual polarized communication systems with techniques for calculating antenna and propagation medium effects. Simple models for the calculation of average annual attenuation and cross-polarization discrimination (XPD) are presented. Calculation of worst month statistics are also presented.

Life Sciences and Space Research 25 (2) Radiation Biology: Topical Meeting of the COSPAR Interdisciplinary Scientific Commission F of the COSPAR 29th Plenary Meeting, Washington, DC, Aug. 28-Sep. 5, 1992

NASA Technical Reports Server (NTRS)

Horneck, G. (Editor); Buecher, H. (Editor); Cox, A. (Editor); Todd, P. (Editor); Yang, T. C. (Editor); Worgul, B. V. (Editor); Donlon, M. (Editor); Atwell, W. (Editor); Shea, M. A. (Editor); Smart, D. F. (Editor)

1994-01-01

Papers presented on long-term exposure to ionizing radiation, obtained from the Long Duration Exposure Facility, included radiation monitoring, radiation effects, and dosimetry. Mechanisms of biological systems, especially cells, under ionizing radiation and relative biological effectiveness were compared. The role of HZE particles as agents of mutation were reported from plant, animal, and in vitro models. Data on known and predicted effects of cosmic rays and other solar radiation on biological systems included differences related to Linear Energy Transfer and heavy ion particles.

Dynamic modelling and response characteristics of a magnetic bearing rotor system including auxiliary bearings

NASA Technical Reports Server (NTRS)

Free, April M.; Flowers, George T.; Trent, Victor S.

1993-01-01

Auxiliary bearings are a critical feature of any magnetic bearing system. They protect the soft iron core of the magnetic bearing during an overload or failure. An auxiliary bearing typically consists of a rolling element bearing or bushing with a clearance gap between the rotor and the inner race of the support. The dynamics of such systems can be quite complex. It is desired to develop a rotor-dynamic model and assess the dynamic behavior of a magnetic bearing rotor system which includes the effects of auxiliary bearings. Of particular interest is the effects of introducing sideloading into such a system during failure of the magnetic bearing. A model is developed from an experimental test facility and a number of simulation studies are performed. These results are presented and discussed.

Non-ionising electromagnetic environments on manned spacecraft.

PubMed

Murphy, J R

1989-08-01

Future space travellers and settlers will be exposed to a variety of electromagnetic fields (EMFs). Extrinsic sources will include solar and stellar fluxes, planetary fluxes, and supernovae. Intrinsic sources may include fusion and ion engines, EMFs from electrical equipment, radar, lighting, superconduction energy storage systems, magnetic bearings on gyroscopic control and orientation systems, and magnetic rail microprobe launch systems. Communication sources may include radio and microwave frequencies, and laser generating systems. Magnetic fields may also be used for deflection of radiation. There is also a loss of the normal Geomagnetic field (GMF) which includes static, alternating, and time-varying components. This paper reviews exposure limits and the biological effects of EMFs, and evidence for an electromagnetic sense organ and a relationship between man and the Geomagnetic field.

Attitude determination of a high altitude balloon system. Part 1: Development of the mathematical model

NASA Technical Reports Server (NTRS)

Nigro, N. J.; Elkouh, A. F.; Shen, K. S.; Nimityongskul, P.; Jhaveri, V. N.; Sethi, A.

1975-01-01

A mathematical model for predicting the three dimensional motion of the balloon system is developed, which includes the effects of bounce, pendulation and spin of each subsystem. Boundary layer effects are also examined, along with the aerodynamic forces acting on the balloon. Various simplified forms of the system mathematical model were developed, based on an order of magnitude analysis.

21 CFR 1300.01 - Definitions relating to controlled substances.

Code of Federal Regulations, 2012 CFR

2012-04-01

... substances having a depressant effect on the central nervous system, including its salts, isomers, and salts... paragraph. Automated dispensing system means a mechanical system that performs operations or activities... 1305.06. Readily retrievable means that certain records are kept by automatic data processing systems...

21 CFR 1300.01 - Definitions relating to controlled substances.

Code of Federal Regulations, 2013 CFR

2013-04-01

... substances having a depressant effect on the central nervous system, including its salts, isomers, and salts... paragraph. Automated dispensing system means a mechanical system that performs operations or activities... 1305.06. Readily retrievable means that certain records are kept by automatic data processing systems...

21 CFR 1300.01 - Definitions relating to controlled substances.

Code of Federal Regulations, 2014 CFR

2014-04-01

... substances having a depressant effect on the central nervous system, including its salts, isomers, and salts... paragraph. Automated dispensing system means a mechanical system that performs operations or activities... 1305.06. Readily retrievable means that certain records are kept by automatic data processing systems...

A Logic Basis for Information Retrieval.

ERIC Educational Resources Information Center

Watters, C. R.; Shepherd, M. A.

1987-01-01

Discusses the potential of recent work in artificial intelligence, especially expert systems, for the development of more effective information retrieval systems. Highlights include the role of an expert bibliographic retrieval system and a prototype expert retrieval system, PROBIB-2, that uses MicroProlog to provide deductive reasoning…

Inflammation and metabolic disorders.

PubMed

Navab, Mohamad; Gharavi, Nima; Watson, Andrew D

2008-07-01

Poor nutrition, overweight and obesity have increasingly become a public health concern as they affect many metabolic disorders, including heart disease, diabetes, digestive system disorders, and renal failure. Study of the effects of life style including healthy nutrition will help further elucidate the mechanisms involved in the adverse effects of poor nutrition. Unhealthy life style including poor nutrition can result in imbalance in our oxidation/redox systems. Lipids can undergo oxidative modification by lipoxygenases, cyclooxygenases, myeloperoxidase, and other enzymes. Oxidized phospholipids can induce inflammatory molecules in the liver and other organs. This can contribute to inflammation, leading to coronary heart disease, stroke, renal failure, inflammatory bowl disease, metabolic syndrome, bone and joint disorders, and even certain types of cancer. Our antioxidant and antiinflammatory defense mechanisms contribute to a balance between the stimulators and the inhibitors of inflammation. Beyond a point, however, these systems might be overwhelmed and eventually fail. High-density lipoprotein is a potent inhibitor of the formation of toxic oxidized lipids. High-density lipoprotein is also an effective system for stimulating the genes whose products are active in the removal, inactivation, and elimination of toxic lipids. Supporting the high-density lipoprotein function should help maintain the balance in these systems. It is hoped that the present report would elucidate some of the ongoing work toward this goal.

Automatic system for computer program documentation

NASA Technical Reports Server (NTRS)

Simmons, D. B.; Elliott, R. W.; Arseven, S.; Colunga, D.

1972-01-01

Work done on a project to design an automatic system for computer program documentation aids was made to determine what existing programs could be used effectively to document computer programs. Results of the study are included in the form of an extensive bibliography and working papers on appropriate operating systems, text editors, program editors, data structures, standards, decision tables, flowchart systems, and proprietary documentation aids. The preliminary design for an automated documentation system is also included. An actual program has been documented in detail to demonstrate the types of output that can be produced by the proposed system.

Adaptive control system having hedge unit and related apparatus and methods

NASA Technical Reports Server (NTRS)

Johnson, Eric Norman (Inventor); Calise, Anthony J. (Inventor)

2003-01-01

The invention includes an adaptive control system used to control a plant. The adaptive control system includes a hedge unit that receives at least one control signal and a plant state signal. The hedge unit generates a hedge signal based on the control signal, the plant state signal, and a hedge model including a first model having one or more characteristics to which the adaptive control system is not to adapt, and a second model not having the characteristic(s) to which the adaptive control system is not to adapt. The hedge signal is used in the adaptive control system to remove the effect of the characteristic from a signal supplied to an adaptation law unit of the adaptive control system so that the adaptive control system does not adapt to the characteristic in controlling the plant.

Application of actuator-driven pulsed water jet in aneurysmal subarachnoid hemorrhage surgery: its effectiveness for dissection around ruptured aneurysmal walls and subarachnoid clot removal.

PubMed

Endo, Hidenori; Endo, Toshiki; Nakagawa, Atsuhiro; Fujimura, Miki; Tominaga, Teiji

2017-07-01

In clipping surgery for aneurysmal subarachnoid hemorrhage (aSAH), critical steps include clot removal and dissection of aneurysms without premature rupture or brain injuries. To pursue this goal, a piezo actuator-driven pulsed water jet (ADPJ) system was introduced in this study. This study included 42 patients, who suffered aSAH and underwent clipping surgery. Eleven patients underwent surgery with the assistance of the ADPJ system (ADPJ group). In the other 31 patients, surgery was performed without the ADPJ system (Control group). The ADPJ system was used for clot removal and aneurysmal dissection. The clinical impact of the ADPJ system was judged by comparing the rate of premature rupture, degree of clot removal, and clinical outcomes. Intraoperatively, a premature rupture was encountered in 18.2 and 25.8% of cases in the ADPJ and control groups, respectively. Although the differences were not statistically significant, intraoperative observation suggested that the ADPJ system was effective in clot removal and dissection of aneurysms in a safe manner. Computed tomography scans indicated the achievement of higher degrees of clot removal, especially when the ADPJ system was used for cases with preoperative clot volumes of more than 25 ml (p = 0.047, Mann-Whitney U test). Clinical outcomes, including incidence of postoperative brain injury or symptomatic vasospasm, were similar in both groups. We described our preliminary surgical results using the ADPJ system for aSAH. Although further study is needed, the ADPJ system was considered a safe and effective tool for clot removal and dissection of aneurysms.

The effect of tonsillectomy on the immune system: A systematic review and meta-analysis.

PubMed

Bitar, Mohamad A; Dowli, Alexander; Mourad, Marc

2015-08-01

The immunological sequelae of tonsillectomy in children have been a source of debate among physicians and a continuous concern for parents. Contradictory pertinent results exist in the literature. To understand the real effect of tonsillectomy on the immune system. MEDLINE, EMBASE and COCHRANE. Articles addressing the effect of tonsillectomy on the immune system, up to Dec 2014. Related keywords and medical subject headings were used during the search. The abstracts were reviewed to determine suitability for inclusion based on a set of criteria. Manual crosscheck of references was performed. We checked the tests results and the conclusion of each study to classify it as supporting or refuting the hypothesis of a negative effect of tonsillectomy on the immune system. We reviewed 35 articles, published between 1971 and 2014, including 1997 patients. Only Four studies (11.4%), including 406 patients (20.3%) found that tonsillectomy negatively affects the immune system. We performed a separate meta-analysis on various reviewed humoral and cellular immunological parameters (e.g. total and specific serum Ig's, SecIgA, cellular immunity, and Ag specific Ig). There is more evidence to suggest that tonsillectomy has no negative clinical or immunological sequalae on the immune system. Study limitations included heterogeneity in the diagnostic tools, timing of testing, indication for tonsillectomy and patients' age. It is reasonable to say that there is enough evidence to conclude that tonsillectomy has no clinically significant negative effect on the immune system. It will be important for future studies to uniformly use both preoperative and control laboratory tests' levels to compare the postoperative levels with, to have short and long term follow-up levels, and to include both humoral and cellular immunity in their measurements. The results should reassure both surgeons and parents that tonsillectomy has no proven clinical sequalae. If more research is to be done in the future, it should be performed in a standardized way to avoid the heterogeneity seen in the literature. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

75 FR 49813 - List of Approved Spent Fuel Storage Casks: MAGNASTOR System, Revision 1, Confirmation of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... Storage Casks: MAGNASTOR System, Revision 1, Confirmation of Effective Date AGENCY: Nuclear Regulatory... spent fuel storage regulations at 10 CFR 72.214 to revise the MAGNASTOR System listing to include...

Solar Radio Burst Effects and Meteor Effects: Operational Products Under Development at the Joint SMC-AFRL Rapid Prototyping Center

NASA Astrophysics Data System (ADS)

Quigley, S.

2002-05-01

The Air Force Research Laboratory (AFRL/VSB) and Detachment 11, Space & Missile Systems Center (SMC, Det 11/CIT) have combined efforts to design, develop, test, and implement graphical products for the Air Force's space weather operations center. These products are generated to analyze, specify, and forecast the effects of the near-earth space environment on Department of Defense systems and communications. Jointly-developed products that will be added to real-time operations in the near future include a solar radio background and burst effects (SoRBE) product suite, and a meteor effects (ME) product suite. The SoRBE product addresses the effect of background and event-level solar radio output on operational DoD systems. Strong bursts of radio wave emissions given off by the sun during solar ``events'' can detrimentally affect radar and satellite communication systems that have operational receiving geometries within the field of view of the sun. For some systems, even the background radiation from the sun can produce effects. The radio frequency interference (RFI) of interest occurs on VHF, UHF, and SHF frequency bands, usually lasting several minutes during a solar flare. While such effects are limited in time and area (typically a few degrees in viewing angle), they can be quite severe in magnitude. The result can be a significant lack in a radar system's ability to detect and/or track an object, and loss of a communication system's ability to receive satellite signals. The ME product will address the detrimental effects of meteors on operational DoD systems. These include impacts on satellites, visible trail observations, and radar clutter. While certain types of individual meteors can produce system effects, the initial ME product will address the more generalized range of meteor shower activity and associated affects. These effects can result in damage to satellites, incorrect assessment of satellite sensor observations, and false target returns on radar systems. For both of these products, we describe the background science and operational history; along with product inputs, outputs, dissemination, and customer uses.

Multi-disciplinary coupling for integrated design of propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1993-01-01

Effective computational simulation procedures are described for modeling the inherent multi-disciplinary interactions for determining the true response of propulsion systems. Results are presented for propulsion system responses including multi-discipline coupling effects via (1) coupled multi-discipline tailoring, (2) an integrated system of multidisciplinary simulators, (3) coupled material-behavior/fabrication-process tailoring, (4) sensitivities using a probabilistic simulator, and (5) coupled materials/structures/fracture/probabilistic behavior simulator. The results show that the best designs can be determined if the analysis/tailoring methods account for the multi-disciplinary coupling effects. The coupling across disciplines can be used to develop an integrated interactive multi-discipline numerical propulsion system simulator.

Space environmental effects on spacecraft: LEO materials selection guide, part 2

NASA Astrophysics Data System (ADS)

Silverman, Edward M.

1995-08-01

This document provides performance properties on major spacecraft materials and subsystems that have been exposed to the low-Earth orbit (LEO) space environment. Spacecraft materials include metals, polymers, composites, white and black paints, thermal-control blankets, adhesives, and lubricants. Spacecraft subsystems include optical components, solar cells, and electronics. Information has been compiled from LEO short-term spaceflight experiments (e.g., space shuttle) and from retrieved satellites of longer mission durations (e.g., Long Duration Exposure Facility). Major space environment effects include atomic oxygen (AO), ultraviolet radiation, micrometeoroids and debris, contamination, and particle radiation. The main objective of this document is to provide a decision tool to designers for designing spacecraft and structures. This document identifies the space environments that will affect the performance of materials and components, e.g., thermal-optical property changes of paints due to UV exposures, AO-induced surface erosion of composites, dimensional changes due to thermal cycling, vacuum-induced moisture outgassing, and surface optical changes due to AO/UV exposures. Where appropriate, relationships between the space environment and the attendant material/system effects are identified. Part 2 covers thermal control systems, power systems, optical components, electronic systems, and applications.

Space environmental effects on spacecraft: LEO materials selection guide, part 2

NASA Technical Reports Server (NTRS)

Silverman, Edward M.

1995-01-01

This document provides performance properties on major spacecraft materials and subsystems that have been exposed to the low-Earth orbit (LEO) space environment. Spacecraft materials include metals, polymers, composites, white and black paints, thermal-control blankets, adhesives, and lubricants. Spacecraft subsystems include optical components, solar cells, and electronics. Information has been compiled from LEO short-term spaceflight experiments (e.g., space shuttle) and from retrieved satellites of longer mission durations (e.g., Long Duration Exposure Facility). Major space environment effects include atomic oxygen (AO), ultraviolet radiation, micrometeoroids and debris, contamination, and particle radiation. The main objective of this document is to provide a decision tool to designers for designing spacecraft and structures. This document identifies the space environments that will affect the performance of materials and components, e.g., thermal-optical property changes of paints due to UV exposures, AO-induced surface erosion of composites, dimensional changes due to thermal cycling, vacuum-induced moisture outgassing, and surface optical changes due to AO/UV exposures. Where appropriate, relationships between the space environment and the attendant material/system effects are identified. Part 2 covers thermal control systems, power systems, optical components, electronic systems, and applications.

Effects of direction of rotation in continuous and discontinuous 8 hour shift systems

PubMed Central

Tucker, P.; Smith, L.; Macdonald, I.; Folkard, S.

2000-01-01

OBJECTIVES—Previous research has produced conflicting evidence on the relative merits of advancing and delaying shift systems. The current study assessed the effects of the direction of shift rotation within 8 hour systems, upon a range of measures including sleep, on shift alertness, physical health, and psychological wellbeing.
METHODS—An abridged version of the standard shiftwork index which included retrospective alertness ratings was completed by four groups of industrial shiftworkers on relatively rapidly rotating 8 hour systems (n=611). Two groups worked continuous systems that were either advancing or delaying; the other two groups worked discontinuous systems that were either advancing or delaying.
RESULTS—Few effects were found of direction of rotation on chronic measures of health and wellbeing, even when the systems incorporated "quick returns" (a break of only 8 hours when changing from one shift to another). This was despite the use of measures previously shown to be sensitive to the effects of a broad range of features of shift systems. However, advancing continuous systems seemed to be associated with marginally steeper declines in alertness across the shift (F (3,1080)=2.87, p<0.05). They were also associated with shorter sleeps between morning shifts (F (1,404)=4.01, p<0.05), but longer sleeps between afternoons (F (1,424)=4.16, p<0.05).
CONCLUSIONS—The absence of negative effects of advancing shifts upon the chronic outcome measures accorded with previous evidence that advancing shifts may not be as harmful as early research indicated. However, this interpretation is tempered by the possibility that difficult shift systems self select those workers most able to cope with their deleterious effects. The presence of quick returns in advancing continuous systems seemed to impact upon some of the acute measures such as duration of sleep, although the associated effects on alertness seemed to be marginal.


Keywords: shift rotation; health; alertness PMID:10984340

Thyroid disease and the cardiovascular system.

PubMed

Danzi, Sara; Klein, Irwin

2014-06-01

Thyroid hormones, specifically triiodothyronine (T3), have significant effects on the heart and cardiovascular system. Hypothyroidism, hyperthyroidism, subclinical thyroid disease, and low T3 syndrome each cause cardiac and cardiovascular abnormalities through both genomic and nongenomic effects on cardiac myocytes and vascular smooth muscle cells. In compromised health, such as occurs in heart disease, alterations in thyroid hormone metabolism may further impair cardiac and cardiovascular function. Diagnosis and treatment of cardiac disease may benefit from including analysis of thyroid hormone status, including serum total T3 levels. Copyright © 2014 Elsevier Inc. All rights reserved.

Reproductive effects in birds exposed to pesticides and industrial chemicals.

PubMed Central

Fry, D M

1995-01-01

Environmental contamination by agricultural chemicals and industrial waste disposal results in adverse effects on reproduction of exposed birds. The diversity of pollutants results in physiological effects at several levels, including direct effects on breeding adults as well as developmental effects on embryos. The effects on embryos include mortality or reduced hatchability, failure of chicks to thrive (wasting syndrome), and teratological effects producing skeletal abnormalities and impaired differentiation of the reproductive and nervous systems through mechanisms of hormonal mimicking of estrogens. The range of chemical effects on adult birds covers acute mortality, sublethal stress, reduced fertility, suppression of egg formation, eggshell thinning, and impaired incubation and chick rearing behaviors. The types of pollutants shown to cause reproductive effects include organochlorine pesticides and industrial pollutants, organophosphate pesticides, petroleum hydrocarbons, heavy metals, and in a fewer number of reports, herbicides, and fungicides. o,p'-DDT, polychlorinated biphenyls (PCBs), and mixtures of organochlorines have been identified as environmental estrogens affecting populations of gulls breeding in polluted "hot spots" in southern California, the Great Lakes, and Puget Sound. Estrogenic organochlorines represent an important class of toxicants to birds because differentiation of the avian reproductive system is estrogen dependent. PMID:8593865

48 CFR 7.101 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... produce quality systems. This includes ensuring that only necessary and cost-effective requirements are... that involve redesign of systems or subsystems. Life-cycle cost means the total cost to the Government...

48 CFR 7.101 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... produce quality systems. This includes ensuring that only necessary and cost-effective requirements are... that involve redesign of systems or subsystems. Life-cycle cost means the total cost to the Government...

Oxytocin for the treatment of drug and alcohol use disorders.

PubMed

Lee, Mary R; Weerts, Elise M

2016-12-01

There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and other substance-use disorders. OT is a neuropeptide that modulates adaptive processes associated with addiction including reward, tolerance, associative learning, memory, and stress responses. OT exerts its effects through interactions with the hypothalamic-pituitary-adrenal axis and multiple neurotransmitter systems including the dopamine mesolimbic reward and corticotrophin-releasing factor stress systems. The effects of OT on stress systems are of high interest, given the strong link between stress, drug use and relapse, and known dysregulation of hypothalamic-pituitary-adrenal-axis activity associated with substance-use disorders. At the same time, the OT system is itself altered by acute or chronic drug exposure. This review summarizes the preclinical and clinical literature on the OT system and its relevance to drug and alcohol addiction. In addition, findings from recent clinical trials conducted in participants with cocaine, cannabis, or alcohol use disorder are included and evidence that OT may help to normalize blunted stress responses, and attenuate withdrawal-associated hypercortisolism, negative mood, and withdrawal symptoms is summarized.

Working group organizational meeting

NASA Technical Reports Server (NTRS)

1982-01-01

Scene radiation and atmospheric effects, mathematical pattern recognition and image analysis, information evaluation and utilization, and electromagnetic measurements and signal handling are considered. Research issues in sensors and signals, including radar (SAR) reflectometry, SAR processing speed, registration, including overlay of SAR and optical imagery, entire system radiance calibration, and lack of requirements for both sensors and systems, etc. were discussed.

Sociocultural Systems: The Next Step in Army Cultural Capability

DTIC Science & Technology

2013-09-01

notion of cross-cultural effectiveness in military operations is incomplete if it does not include the concept of sociocultural systems. Discussions...evaluate them, influence them, and operate effectively within them. This research product is an anthology of chapters written by some of the best and...military, and police organizations. Army personnel require a diverse and sophisticated skill set to be effective , and Soldiers often must be

Design, fabrication, assembly, and test of a liquid hydrogen acquisition subsystem

NASA Technical Reports Server (NTRS)

Blackman, J. B.

1974-01-01

The development of a cryogenic fluid system to supply liquid hydrogen to a turbopump at flowrates up to 7.5 pounds per second for a period of approximately 5 seconds before refill, is discussed. Refill is accomplished in less than 10 seconds, during which a constant flowrate can be maintained to the pumps. Diagrams are provided to show the configuration of the system. Subsystem acceptance and functional tests, including acquisition subsystem expulsion, pressurization, and refill were performed. The tests included: (1) thermodynamic vent system operation, (2) warm-gas pressurization effects, (3) hydraulic pressure surge effects, (4) screen device operational limitations, (5) feedline vapor control, and (6) two-phase refill.

Effectiveness of Nursing Management Information Systems: A Systematic Review

PubMed Central

Choi, Mona; Yang, You Lee

2014-01-01

Objectives The purpose of this study was to review evaluation studies of nursing management information systems (NMISs) and their outcome measures to examine system effectiveness. Methods For the systematic review, a literature search of the PubMed, CINAHL, Embase, and Cochrane Library databases was conducted to retrieve original articles published between 1970 and 2014. Medical Subject Headings (MeSH) terms included informatics, medical informatics, nursing informatics, medical informatics application, and management information systems for information systems and evaluation studies and nursing evaluation research for evaluation research. Additionally, manag* and admin*, and nurs* were combined. Title, abstract, and full-text reviews were completed by two reviewers. And then, year, author, type of management system, study purpose, study design, data source, system users, study subjects, and outcomes were extracted from the selected articles. The quality and risk of bias of the studies that were finally selected were assessed with the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS) criteria. Results Out of the 2,257 retrieved articles, a total of six articles were selected. These included two scheduling programs, two nursing cost-related programs, and two patient care management programs. For the outcome measurements, usefulness, time saving, satisfaction, cost, attitude, usability, data quality/completeness/accuracy, and personnel work patterns were included. User satisfaction, time saving, and usefulness mostly showed positive findings. Conclusions The study results suggest that NMISs were effective in time saving and useful in nursing care. Because there was a lack of quality in the reviewed studies, well-designed research, such as randomized controlled trials, should be conducted to more objectively evaluate the effectiveness of NMISs. PMID:25405060

Magnetoresistance in organic semiconductors: Including pair correlations in the kinetic equations for hopping transport

NASA Astrophysics Data System (ADS)

Shumilin, A. V.; Kabanov, V. V.; Dediu, V. I.

2018-03-01

We derive kinetic equations for polaron hopping in organic materials that explicitly take into account the double occupation possibility and pair intersite correlations. The equations include simplified phenomenological spin dynamics and provide a self-consistent framework for the description of the bipolaron mechanism of the organic magnetoresistance. At low applied voltages, the equations can be reduced to those for an effective resistor network that generalizes the Miller-Abrahams network and includes the effect of spin relaxation on the system resistivity. Our theory discloses the close relationship between the organic magnetoresistance and the intersite correlations. Moreover, in the absence of correlations, as in an ordered system with zero Hubbard energy, the magnetoresistance vanishes.

Development of a set of equations for incorporating disk flexibility effects in rotordynamical analyses

NASA Technical Reports Server (NTRS)

Flowers, George T.; Ryan, Stephen G.

1991-01-01

Rotordynamical equations that account for disk flexibility are developed. These equations employ free-free rotor modes to model the rotor system. Only transverse vibrations of the disks are considered, with the shaft/disk system considered to be torsionally rigid. Second order elastic foreshortening effects that couple with the rotor speed to produce first order terms in the equations of motion are included. The approach developed in this study is readily adaptable for usage in many of the codes that are current used in rotordynamical simulations. The equations are similar to those used in standard rigid disk analyses but with additional terms that include the effects of disk flexibility. An example case is presented to demonstrate the use of the equations and to show the influence of disk flexibility on the rotordynamical behavior of a sample system.

Systemic Metabolic Derangement, Pulmonary Effects, and Insulin Insufficiency Following Subchronic Ozone Exposure in Rats

EPA Pesticide Factsheets

This data set includes individual animal data collected for various biological endpoints that are included in the manuscript.Miller DB, Snow SJ, Henriquez A, Schladweiler MC, Ledbetter AD, Richards JE, Andrews DL, Kodavanti UP. Systemic metabolic derangement, pulmonary effects, and insulin insufficiency following subchronic ozone exposure in rats. Toxicol Appl Pharmacol. 2016 Jun 28;306:47-57. The primary author Desinia Miller, an UNC-EPA co-opp Student has since completed her PhD and is no longer in EPA database.This dataset is associated with the following publication:Miller, D., S. Snow, A. Henriquez, M. Schladweiler, A. Ledbetter, J. Richards, D. Andrews, and U. Kodavanti. Systemic Metabolic Derangement, Pulmonary Effects, and Insulin Insufficiency following subchronic ozone exposure in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 306: 47-57, (2016).

Non-seismic tsunamis: filling the forecast gap

NASA Astrophysics Data System (ADS)

Moore, C. W.; Titov, V. V.; Spillane, M. C.

2015-12-01

Earthquakes are the generation mechanism in over 85% of tsunamis. However, non-seismic tsunamis, including those generated by meteorological events, landslides, volcanoes, and asteroid impacts, can inundate significant area and have a large far-field effect. The current National Oceanographic and Atmospheric Administration (NOAA) tsunami forecast system falls short in detecting these phenomena. This study attempts to classify the range of effects possible from these non-seismic threats, and to investigate detection methods appropriate for use in a forecast system. Typical observation platforms are assessed, including DART bottom pressure recorders and tide gauges. Other detection paths include atmospheric pressure anomaly algorithms for detecting meteotsunamis and the early identification of asteroids large enough to produce a regional hazard. Real-time assessment of observations for forecast use can provide guidance to mitigate the effects of a non-seismic tsunami.

Theoretical Study of Spin Crossover in 30 Iron Complexes.

PubMed

Kepp, Kasper P

2016-03-21

Iron complexes are important spin crossover (SCO) systems with vital roles in oxidative metabolism and promising technological potential. The SCO tendency depends on the free energy balance of high- and low-spin states, which again depends on physical effects such as dispersion, relativistic effects, and vibrational entropy. This work studied 30 different iron SCO systems with experimentally known thermochemical data, using 12 different density functionals. Remarkably general entropy-enthalpy compensation across SCO systems was identified (R = 0.82, p = 0.002) that should be considered in rational SCO design. Iron(II) complexes displayed higher ΔH and ΔS values than iron(III) complexes and also less steep compensation effects. First-coordination sphere ΔS values computed from numerical frequencies reproduce most of the experimental entropy and should thus be included when modeling spin-state changes in inorganic chemistry (R = 0.52, p = 3.4 × 10(-3); standard error in TΔS ≈ 4.4 kJ/mol at 298 K vs 16 kJ/mol of total TΔS on average). Zero-point energies favored high-spin states by 9 kJ/mol on average. Interestingly, dispersion effects are surprisingly large for the SCO process (average: 9 kJ/mol, but up to 33 kJ/mol) and favor the more compact low-spin state. Relativistic effects favor low-spin by ∼9 kJ/mol on average, but up to 24 kJ/mol. B3LYP*, TPSSh, B2PLYP, and PW6B95 performed best for the typical calculation scheme that includes ZPE. However, if relativistic and dispersion effects are included, only B3LYP* remained accurate. On average, high-spin was favored by LYP by 11-15 kJ/mol relative to other correlation functionals, and by 4.2 kJ/mol per 1% HF exchange in hybrids. 13% HF exchange was optimal without dispersion, and 15% was optimal with all effects included for these systems.

The Effectiveness of an Electronic Security Management System in a Privately Owned Apartment Complex

ERIC Educational Resources Information Center

Greenberg, David F.; Roush, Jeffrey B.

2009-01-01

Poisson and negative binomial regression methods are used to analyze the monthly time series data to determine the effects of introducing an integrated security management system including closed-circuit television (CCTV), door alarm monitoring, proximity card access, and emergency call boxes to a large privately-owned complex of apartment…

The Student Equity Effects of the Public School Finance System in Louisiana.

ERIC Educational Resources Information Center

Geske, Terry G.; LaCost, Barbara Y.

1990-01-01

Investigates the student equity effects of Louisiana's public school finance program in terms of fiscal neutrality and revenue inequality over a nine-year period, using regression techniques. Overall, Louisiana's system became less equal over the time period examined, while revenue distribution became more equal. Includes 35 references. (MLH)

Life sciences and space research 25 (3): Natural and artifical ecosystems; Meeting F4 of the COSPAR Plenary Meeting, 29th, Washington, DC, Aug. 28-Sep. 5, 1992

NASA Technical Reports Server (NTRS)

Macelroy, R. D. (Editor); Mitchell, C. A. (Editor); Andre, M. (Editor); Blackwell, C. C. (Editor); Tibbitts, T. W. (Editor); Banin, A. (Editor); Levine, J. S. (Editor)

1994-01-01

Bioregenerative life support systems will be an essential part of long duration manned space flight. Studies have been made of various components of these closed ecological systems. these studies have included those spaceborne experiments on Spacelab and Mir, as well as ground-based simulations. The effects of reduced gravity include alterations in food crop and other plant growth and vigor. Systems have also been designed and tested to provide a balanced regenerative system that recycles airborne and other wastes while providing nutrients and other input for future cycles. Hydroponic cultivation must include control of pathogens. All closed systems require sensing and automatic control.

Satellite services system analysis study. Volume 2, part 2: Study results

NASA Technical Reports Server (NTRS)

1981-01-01

The development of an effective satellite services system was investigated. Satek Satellite user market, design reference missions, satellite service functions, service equipment, and cost estimates are discussed. Extensive program plans for a satellite service system implementation are included.

Building Student and Family-Centered Care Coordination Through Ongoing Delivery System Design.

PubMed

Baker, Dian; Anderson, Lori; Johnson, Jody

2017-01-01

In 2016 the National Association of School Nurses released an updated framework for school nurse practice. One highlight of the new framework is 21st century care coordination. That is, moving beyond basic case management to a systems-level approach for delivery of school health services. The framework broadly applies the term care coordination to include direct care and communication across systems. School nurses are often engaged in efforts to create school health care homes that serve as an axis of coordination for students and families between primary care offices and the schools. Effective care coordination requires that the school nurses not only know the principles of traditional case management but also understand complex systems that drive effective care coordination. The outcome of a system-level approach is enhanced access to services in an integrated health care delivery system that includes the school nurse as an integral member of the school's health care team. This article presents a comprehensive, system-level model of care coordination for school nurse leadership and practice.

Operational System-Impact Products for the Space Situational Awareness Environmental Effects Fusion System (SEEFS)

NASA Astrophysics Data System (ADS)

Quigley, S.; Scro, K.

2006-12-01

The Space Vehicles Directorate of the Air Force Research Laboratory (AFRL/VSBX) and the Technology Applications Division of the Space and Missile Systems Center (SMC/WXT) have combined efforts under the Rapid Prototyping Center (RPC) to design, develop, test, implement, and validate numerical and graphical products for the Air Force Space Command (AFSPC) Space Situational Awareness Environmental Effects Fusion System (SEEFS). These products are generated to analyze, specify, and forecast the effects of the near-earth space environment on Department of Defense weapons, navigation, communications, and surveillance systems. Jointly developed projects that have been completed as prototypes and are undergoing development for real-time operations include a SEEFS architecture and database, five system-impact products, and a high-level decision aid product. This first round of SEEFS products includes Solar Radio Burst Effects (SoRBE) on radar and satellite communications, Radar Auroral Clutter (RAC), Scintillation Effects on radar and satellite communications (RadScint and SatScint), and Satellite Surface and Deep Charge/Discharge (Char/D). The SEEFS architecture and database enable modular use and execution of SEEFS products, and the high-level Decision Aid shows the combined effects of all SEEFS product output on a given asset and on multi-asset missions. This presentation provides a general overview of the SEEFS program, along with details of the first round of products expected to be operational for use in exercises and/or real-time operations in 2007-2008.

Integrated Data Modeling and Simulation on the Joint Polar Satellite System Program

NASA Technical Reports Server (NTRS)

Roberts, Christopher J.; Boyce, Leslye; Smith, Gary; Li, Angela; Barrett, Larry

2012-01-01

The Joint Polar Satellite System is a modern, large-scale, complex, multi-mission aerospace program, and presents a variety of design, testing and operational challenges due to: (1) System Scope: multi-mission coordination, role, responsibility and accountability challenges stemming from porous/ill-defined system and organizational boundaries (including foreign policy interactions) (2) Degree of Concurrency: design, implementation, integration, verification and operation occurring simultaneously, at multiple scales in the system hierarchy (3) Multi-Decadal Lifecycle: technical obsolesce, reliability and sustainment concerns, including those related to organizational and industrial base. Additionally, these systems tend to become embedded in the broader societal infrastructure, resulting in new system stakeholders with perhaps different preferences (4) Barriers to Effective Communications: process and cultural issues that emerge due to geographic dispersion and as one spans boundaries including gov./contractor, NASA/Other USG, and international relationships.

Charged Particle Environments in Earth's Magnetosphere and their Effects on Space System

NASA Technical Reports Server (NTRS)

Minow, Joseph I.

2009-01-01

This slide presentation reviews information on space radiation environments important to magnetospheric missions including trapped radiation, solar particle events, cosmic rays, and solar winds. It also includes information about ion penetration of the magnetosphere, galactic cosmic rays, solar particle environments, CRRES internal discharge monitor, surface charging and radiation effects.

Evaluating the effect of the new incentive system for high-risk pressure ulcer patients on wound healing and cost-effectiveness: a cohort study.

PubMed

Sanada, Hiromi; Nakagami, Gojiro; Mizokami, Yuko; Minami, Yukiko; Yamamoto, Aya; Oe, Makoto; Kaitani, Toshiko; Iizaka, Shinji

2010-03-01

To evaluate the effectiveness and cost-effectiveness of new incentive system for pressure ulcer management, which focused on skilled nurse staffing in terms of rate of healing and medical costs. A prospective cohort study included two types of groups: 39 institutions, which introduced the new incentive system, and 20 non-introduced groups (control). Sixty-seven patients suffering from severe pressure ulcers in the introduced group and 38 patients in the non-introduced group were included. Wound healing and medical costs were monitored weekly for three weeks by their skilled nurses in charge. Healing status and related medical costs. The introduced group showed significantly higher rate of healing compared with the control group at each weekly assessment. Multiple regression analysis revealed that the introduction of the new incentive system was independently associated with the faster healing rate (beta=3.44, P<.001). The budget impact analysis demonstrated that introducing this system could reduce cost of treating severe pressure ulcers by 1.776 billion yen per year. The new incentive system for the management of pressure ulcers, which focused on staffing with skilled nurses can improve healing rate with reduced medical cost. Copyright 2009 Elsevier Ltd. All rights reserved.

Shuttle Ku-band and S-band communications implementation study

NASA Technical Reports Server (NTRS)

Dodds, J. G.; Huth, G. K.; Nilsen, P. W.; Polydoros, A.; Simon, M. K.; Weber, C. L.

1980-01-01

Various aspects of the shuttle orbiter S-band network communication system, the S-band payload communication system, and the Ku-band communication system are considered. A method is proposed for obtaining more accurate S-band antenna patterns of the actual shuttle orbiter vehicle during flight because the preliminary antenna patterns using mock-ups are not realistic that they do not include the effects of additional appendages such as wings and tail structures. The Ku-band communication system is discussed especially the TDRS antenna pointing accuracy with respect to the orbiter and the modifications required and resulting performance characteristics of the convolutionally encoded high data rate return link to maintain bit synchronizer lock on the ground. The TDRS user constraints on data bit clock jitter and data asymmetry on unbalanced QPSK with noisy phase references are included. The S-band payload communication system study is outlined including the advantages and experimental results of a peak regulator design built and evaluated by Axiomatrix for the bent-pipe link versus the existing RMS-type regulator. The nominal sweep rate for the deep-space transponder of 250 Hz/s, and effects of phase noise on the performance of a communication system are analyzed.

Cost-effectiveness and performance of overlay systems in Illinois, volume 2 : guidelines for interlayer system selection decision when used in HMA overlays.

DOT National Transportation Integrated Search

2009-05-01

In an effort to control reflective cracking in hot-mix asphalt (HMA) overlays placed over Portland Cement : Concrete (PCC) pavements, several reflective crack control (RCC) systems, including interlayer systems, : have been used. However, the cost-ef...

23 CFR 500.111 - IMS.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false IMS. 500.111 Section 500.111 Highways FEDERAL HIGHWAY... SYSTEMS Management Systems § 500.111 IMS. An effective IMS for intermodal facilities and systems provides... the various land-based transportation facilities and systems. An IMS should include, at a minimum: (a...

Optical Disks Compete with Videotape and Magnetic Storage Media: Part I.

ERIC Educational Resources Information Center

Urrows, Henry; Urrows, Elizabeth

1988-01-01

Describes the latest technology in videotape cassette systems and other magnetic storage devices and their possible effects on optical data disks. Highlights include Honeywell's Very Large Data Store (VLDS); Exabyte's tape cartridge storage system; standards for tape drives; and Masstor System's videotape cartridge system. (LRW)

14 CFR 23.1309 - Equipment, systems, and installations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... environmental conditions, including the indirect effects of lightning strikes. (2) Any equipment and system does... Equipment General § 23.1309 Equipment, systems, and installations. The requirements of this section, except... requirements of part 23, to any equipment or system as installed in the airplane. This section is a regulation...

14 CFR 23.1309 - Equipment, systems, and installations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... environmental conditions, including the indirect effects of lightning strikes. (2) Any equipment and system does... Equipment General § 23.1309 Equipment, systems, and installations. The requirements of this section, except... requirements of part 23, to any equipment or system as installed in the airplane. This section is a regulation...

Primary care providers' experiences caring for complex patients in primary care: a qualitative study.

PubMed

Loeb, Danielle F; Bayliss, Elizabeth A; Candrian, Carey; deGruy, Frank V; Binswanger, Ingrid A

2016-03-22

Complex patients are increasingly common in primary care and often have poor clinical outcomes. Healthcare system barriers to effective care for complex patients have been previously described, but less is known about the potential impact and meaning of caring for complex patients on a daily basis for primary care providers (PCPs). Our objective was to describe PCPs' experiences providing care for complex patients, including their experiences of health system barriers and facilitators and their strategies to enhance provision of effective care. Using a general inductive approach, our qualitative research study was guided by an interpretive epistemology, or way of knowing. Our method for understanding included semi-structured in-depth interviews with internal medicine PCPs from two university-based and three community health clinics. We developed an interview guide, which included questions on PCPs' experiences, perceived system barriers and facilitators, and strategies to improve their ability to effectively treat complex patients. To focus interviews on real cases, providers were asked to bring de-identified clinical notes from patients they considered complex to the interview. Interview transcripts were coded and analyzed to develop categories from the raw data, which were then conceptualized into broad themes after team-based discussion. PCPs (N = 15) described complex patients with multidimensional needs, such as socio-economic, medical, and mental health. A vision of optimal care emerged from the data, which included coordinating care, preventing hospitalizations, and developing patient trust. PCPs relied on professional values and individual care strategies to overcome local and system barriers. Team based approaches were endorsed to improve the management of complex patients. Given the barriers to effective care described by PCPs, individual PCP efforts alone are unlikely to meet the needs of complex patients. To fulfill PCP's expressed concepts of optimal care, implementation of effective systemic approaches should be considered.

Virtual Earth System Laboratory (VESL): Effective Visualization of Earth System Data and Process Simulations

NASA Astrophysics Data System (ADS)

Quinn, J. D.; Larour, E. Y.; Cheng, D. L. C.; Halkides, D. J.

2016-12-01

The Virtual Earth System Laboratory (VESL) is a Web-based tool, under development at the Jet Propulsion Laboratory and UC Irvine, for the visualization of Earth System data and process simulations. It contains features geared toward a range of applications, spanning research and outreach. It offers an intuitive user interface, in which model inputs are changed using sliders and other interactive components. Current capabilities include simulation of polar ice sheet responses to climate forcing, based on NASA's Ice Sheet System Model (ISSM). We believe that the visualization of data is most effective when tailored to the target audience, and that many of the best practices for modern Web design/development can be applied directly to the visualization of data: use of negative space, color schemes, typography, accessibility standards, tooltips, etc cetera. We present our prototype website, and invite input from potential users, including researchers, educators, and students.

The United States Remains Unprepared for Oil Import Disruptions. Volume I. Summary: Includes Conclusions and Recommendations.

DTIC Science & Technology

1981-09-29

The Administration’s decision to stop funding rationing planning means it will not be available for emergency use. Authority for gaso- line rationing ...them. It will be a very narrow system in order to minimize adverse effects on market decision - making and efficiency. However, until such a system is...It will be a very narrow system in order to minimize adverse effects on market decision - making and efficiency. However, until such a system is

Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs.

PubMed Central

Brouwer, A; Longnecker, M P; Birnbaum, L S; Cogliano, J; Kostyniak, P; Moore, J; Schantz, S; Winneke, G

1999-01-01

This article addresses issues related to the characterization of endocrine-related health effects resulting from low-level exposures to polychlorinated biphenyls (PCBs). It is not intended to be a comprehensive review of the literature but reflects workshop discussions. "The Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels," workshop provided a forum to discuss the methods and data needed to improve risk assessments of endocrine disruptors. This article contains an overview of endocrine-related (estrogen and thyroid system) interactions and other low-dose effects of PCBs. The data set on endocrine effects includes results obtained from mechanistic methods/ and models (receptor based, metabolism based, and transport protein based), as well as from (italic)in vivo(/italic) models, including studies with experimental animals and wildlife species. Other low-dose effects induced by PCBs, such as neurodevelopmental and reproductive effects and endocrine-sensitive tumors, have been evaluated with respect to a possible causative linkage with PCB-induced alterations in endocrine systems. In addition, studies of low-dose exposure and effects in human populations are presented and critically evaluated. A list of conclusions and recommendations is included. PMID:10421775

A digital computer program for the dynamic interaction simulation of controls and structure (DISCOS), volume 1

NASA Technical Reports Server (NTRS)

Bodley, C. S.; Devers, A. D.; Park, A. C.; Frisch, H. P.

1978-01-01

A theoretical development and associated digital computer program system for the dynamic simulation and stability analysis of passive and actively controlled spacecraft are presented. The dynamic system (spacecraft) is modeled as an assembly of rigid and/or flexible bodies not necessarily in a topological tree configuration. The computer program system is used to investigate total system dynamic characteristics, including interaction effects between rigid and/or flexible bodies, control systems, and a wide range of environmental loadings. In addition, the program system is used for designing attitude control systems and for evaluating total dynamic system performance, including time domain response and frequency domain stability analyses.

Time-reversal MUSIC imaging of extended targets.

PubMed

Marengo, Edwin A; Gruber, Fred K; Simonetti, Francesco

2007-08-01

This paper develops, within a general framework that is applicable to rather arbitrary electromagnetic and acoustic remote sensing systems, a theory of time-reversal "MUltiple Signal Classification" (MUSIC)-based imaging of extended (nonpoint-like) scatterers (targets). The general analysis applies to arbitrary remote sensing geometry and sheds light onto how the singular system of the scattering matrix relates to the geometrical and propagation characteristics of the entire transmitter-target-receiver system and how to use this effect for imaging. All the developments are derived within exact scattering theory which includes multiple scattering effects. The derived time-reversal MUSIC methods include both interior sampling, as well as exterior sampling (or enclosure) approaches. For presentation simplicity, particular attention is given to the time-harmonic case where the informational wave modes employed for target interrogation are purely spatial, but the corresponding generalization to broadband fields is also given. This paper includes computer simulations illustrating the derived theory and algorithms.

Maximizing the Potential of Telecommunications Technology.

ERIC Educational Resources Information Center

Young, Dennis M.

2003-01-01

Offers advice on planning a reliable and cost-effective school telecommunications system, including issues such as the layered nature of many schools' systems, and the move from centralized to distributed networks. (EV)

Tutorial: Radiation Effects in Electronic Systems

NASA Technical Reports Server (NTRS)

Pellish, Jonathan A.

2017-01-01

This tutorial presentation will give an overview of radiation effects in electrical, electronic, and electromechanical (EEE) components as it applies to civilian space systems of varying size and complexity. The natural space environment presents many unique threats to electronic systems regardless of where the systems operate from low-Earth orbit to interplanetary space. The presentation will cover several topics, including: an overview and introduction to the applicable space radiation environments common to a broad range of mission designs; definitions and impacts of effects due to impinging particles in the space environment e.g., total ionizing dose (TID), total non-ionizing dose (TNID), and single-event effects (SEE); and, testing for and evaluation of TID, TNID, and SEE in EEE components.

Three axis electronic flight motion simulator real time control system design and implementation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Zhiyuan; Miao, Zhonghua, E-mail: zhonghua-miao@163.com; Wang, Xiaohua

2014-12-15

A three axis electronic flight motion simulator is reported in this paper including the modelling, the controller design as well as the hardware implementation. This flight motion simulator could be used for inertial navigation test and high precision inertial navigation system with good dynamic and static performances. A real time control system is designed, several control system implementation problems were solved including time unification with parallel port interrupt, high speed finding-zero method of rotary inductosyn, zero-crossing management with continuous rotary, etc. Tests were carried out to show the effectiveness of the proposed real time control system.

Three axis electronic flight motion simulator real time control system design and implementation.

PubMed

Gao, Zhiyuan; Miao, Zhonghua; Wang, Xuyong; Wang, Xiaohua

2014-12-01

A three axis electronic flight motion simulator is reported in this paper including the modelling, the controller design as well as the hardware implementation. This flight motion simulator could be used for inertial navigation test and high precision inertial navigation system with good dynamic and static performances. A real time control system is designed, several control system implementation problems were solved including time unification with parallel port interrupt, high speed finding-zero method of rotary inductosyn, zero-crossing management with continuous rotary, etc. Tests were carried out to show the effectiveness of the proposed real time control system.

Using surveillance data to estimate pandemic vaccine effectiveness against laboratory confirmed influenza A(H1N1)2009 infection: two case-control studies, Spain, season 2009-2010

PubMed Central

2011-01-01

Background Physicians of the Spanish Influenza Sentinel Surveillance System report and systematically swab patients attended to their practices for influenza-like illness (ILI). Within the surveillance system, some Spanish regions also participated in an observational study aiming at estimating influenza vaccine effectiveness (cycEVA study). During the season 2009-2010, we estimated pandemic influenza vaccine effectiveness using both the influenza surveillance data and the cycEVA study. Methods We conducted two case-control studies using the test-negative design, between weeks 48/2009 and 8/2010 of the pandemic season. The surveillance-based study included all swabbed patients in the sentinel surveillance system. The cycEVA study included swabbed patients from seven Spanish regions. Cases were laboratory-confirmed pandemic influenza A(H1N1)2009. Controls were ILI patients testing negative for any type of influenza. Variables collected in both studies included demographic data, vaccination status, laboratory results, chronic conditions, and pregnancy. Additionally, cycEVA questionnaire collected data on previous influenza vaccination, smoking, functional status, hospitalisations, visits to the general practitioners, and obesity. We used logistic regression to calculate adjusted odds ratios (OR), computing pandemic influenza vaccine effectiveness as (1-OR)*100. Results We included 331 cases and 995 controls in the surveillance-based study and 85 cases and 351 controls in the cycEVA study. We detected nine (2.7%) and two (2.4%) vaccine failures in the surveillance-based and cycEVA studies, respectively. Adjusting for variables collected in surveillance database and swabbing month, pandemic influenza vaccine effectiveness was 62% (95% confidence interval (CI): -5; 87). The cycEVA vaccine effectiveness was 64% (95%CI: -225; 96) when adjusting for common variables with the surveillance system and 75% (95%CI: -293; 98) adjusting for all variables collected. Conclusion Point estimates of the pandemic influenza vaccine effectiveness suggested a protective effect of the pandemic vaccine against laboratory-confirmed influenza A(H1N1)2009 in the season 2009-2010. Both studies were limited by the low vaccine coverage and the late start of the vaccination campaign. Routine influenza surveillance provides reliable estimates and could be used for influenza vaccine effectiveness studies in future seasons taken into account the surveillance system limitations. PMID:22129083

Metal-Air Batteries: (Latest citations from the Aerospace Database)

NASA Technical Reports Server (NTRS)

1997-01-01

The bibliography contains citations concerning applications of metal-air batteries. Topics include systems that possess different practical energy densities at specific powers. Coverage includes the operation of air electrodes at different densities and performance results. The systems are used in electric vehicles as a cost-effective method to achieve reliability and efficiency. Zinc-air batteries are covered more thoroughly in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.)

Polarization effects on hard target calibration of lidar systems

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.

1987-01-01

The theory of hard target calibration of lidar backscatter data, including laboratory measurements of the pertinent target reflectance parameters, is extended to include the effects of polarization of the transmitted and received laser radiation. The bidirectional reflectance-distribution function model of reflectance is expanded to a 4 x 4 matrix allowing Mueller matrix and Stokes vector calculus to be employed. Target reflectance parameters for calibration of lidar backscatter data are derived for various lidar system polarization configurations from integrating sphere and monostatic reflectometer measurements. It is found that correct modeling of polarization effects is mandatory for accurate calibration of hard target reflectance parameters and, therefore, for accurate calibration of lidar backscatter data.

Capabilities of the Environmental Effects Branch at Marshall Space Flight Cente

NASA Technical Reports Server (NTRS)

Rogers, Jan; Finckenor, Miria; Nehls, Mary

2016-01-01

The Environmental Effects Branch at the Marshall Space Flight Center supports a myriad array of programs for NASA, DoD, and commercial space including human exploration, advanced space propulsion, improving life on Earth, and the study of the Sun, the Earth, and the solar system. The branch provides testing, evaluation, and qualification of materials for use on external spacecraft surfaces and in contamination-sensitive systems. Space environment capabilities include charged particle radiation, ultraviolet radiation, atomic oxygen, impact, plasma, and thermal vacuum, anchored by flight experiments and analysis of returned space hardware. These environmental components can be combined for solar wind or planetary surface environment studies or to evaluate synergistic effects. The Impact Testing Facility allows simulation of impacts ranging from sand and rain to micrometeoroids and orbital debris in order to evaluate materials and components for flight and ground-based systems. The Contamination Control Team is involved in the evaluation of environmentally-friendly replacements for HCFC-225 for use in propulsion oxygen systems, developing cleaning methods for additively manufactured hardware, and reducing risk for the Space Launch System.

Evaluation of health care system reform in Hubei Province, China.

PubMed

Sang, Shuping; Wang, Zhenkun; Yu, Chuanhua

2014-02-21

This study established a set of indicators for and evaluated the effects of health care system reform in Hubei Province (China) from 2009 to 2011 with the purpose of providing guidance to policy-makers regarding health care system reform. The resulting indicators are based on the "Result Chain" logic model and include the following four domains: Inputs and Processes, Outputs, Outcomes and Impact. Health care system reform was evaluated using the weighted TOPSIS and weighted Rank Sum Ratio methods. Ultimately, the study established a set of indicators including four grade-1 indicators, 16 grade-2 indicators and 76 grade-3 indicators. The effects of the reforms increased year by year from 2009 to 2011 in Hubei Province. The health status of urban and rural populations and the accessibility, equity and quality of health services in Hubei Province were improved after the reforms. This sub-national case can be considered an example of a useful approach to the evaluation of the effects of health care system reform, one that could potentially be applied in other provinces or nationally.

Method and system for measurement of mechanical properties of molecules and cells

NASA Technical Reports Server (NTRS)

Fredberg, Jeffrey J. (Inventor); Butler, James P. (Inventor); Ingber, Donald E. (Inventor); Wang, Ning (Inventor)

1996-01-01

Mechanical stresses and deformations are applied directly to cell surface receptors or molecules and measured using a system including a magnetic twisting device in combination with ferromagnetic microbeads coated with ligands for integrins or any other surface receptors. The system can be used diagnostically to characterize cells and molecules and to determine the effect of transformation and compounds, including drugs, on the cells and molecules. The system can also be used to induce cells to grow or alter production of molecules by the cells.

SINGLE EVENT EFFECTS TEST FACILITY AT OAK RIDGE NATIONAL LABORATORY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riemer, Bernie; Gallmeier, Franz X; Dominik, Laura J

2015-01-01

Increasing use of microelectronics of ever diminishing feature size in avionics systems has led to a growing Single Event Effects (SEE) susceptibility arising from the highly ionizing interactions of cosmic rays and solar particles. Single event effects caused by atmospheric radiation have been recognized in recent years as a design issue for avionics equipment and systems. To ensure a system meets all its safety and reliability requirements, SEE induced upsets and potential system failures need to be considered, including testing of the components and systems in a neutron beam. Testing of ICs and systems for use in radiation environments requiresmore » the utilization of highly advanced laboratory facilities that can run evaluations on microcircuits for the effects of radiation. This paper provides a background of the atmospheric radiation phenomenon and the resulting single event effects, including single event upset (SEU) and latch up conditions. A study investigating requirements for future single event effect irradiation test facilities and developing options at the Spallation Neutron Source (SNS) is summarized. The relatively new SNS with its 1.0 GeV proton beam, typical operation of 5000 h per year, expertise in spallation neutron sources, user program infrastructure, and decades of useful life ahead is well suited for hosting a world-class SEE test facility in North America. Emphasis was put on testing of large avionics systems while still providing tunable high flux irradiation conditions for component tests. Makers of ground-based systems would also be served well by these facilities. Three options are described; the most capable, flexible, and highest-test-capacity option is a new stand-alone target station using about one kW of proton beam power on a gas-cooled tungsten target, with dual test enclosures. Less expensive options are also described.« less

Single Event Effects Test Facility Options at the Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riemer, Bernie; Gallmeier, Franz X; Dominik, Laura J

2015-01-01

Increasing use of microelectronics of ever diminishing feature size in avionics systems has led to a growing Single Event Effects (SEE) susceptibility arising from the highly ionizing interactions of cosmic rays and solar particles. Single event effects caused by atmospheric radiation have been recognized in recent years as a design issue for avionics equipment and systems. To ensure a system meets all its safety and reliability requirements, SEE induced upsets and potential system failures need to be considered, including testing of the components and systems in a neutron beam. Testing of integrated circuits (ICs) and systems for use in radiationmore » environments requires the utilization of highly advanced laboratory facilities that can run evaluations on microcircuits for the effects of radiation. This paper provides a background of the atmospheric radiation phenomenon and the resulting single event effects, including single event upset (SEU) and latch up conditions. A study investigating requirements for future single event effect irradiation test facilities and developing options at the Spallation Neutron Source (SNS) is summarized. The relatively new SNS with its 1.0 GeV proton beam, typical operation of 5000 h per year, expertise in spallation neutron sources, user program infrastructure, and decades of useful life ahead is well suited for hosting a world-class SEE test facility in North America. Emphasis was put on testing of large avionics systems while still providing tunable high flux irradiation conditions for component tests. Makers of ground-based systems would also be served well by these facilities. Three options are described; the most capable, flexible, and highest-test-capacity option is a new stand-alone target station using about one kW of proton beam power on a gas-cooled tungsten target, with dual test enclosures. Less expensive options are also described.« less

23 CFR 500.108 - SMS.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Management Systems: Good Practices for Development and Implementation.” 3 An effective SMS should include, at... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.108 SMS. An SMS is a systematic process with the goal of reducing the...

23 CFR 500.108 - SMS.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Management Systems: Good Practices for Development and Implementation.” 3 An effective SMS should include, at... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.108 SMS. An SMS is a systematic process with the goal of reducing the...

Bicellar systems for in vitro percutaneous absorption of diclofenac.

PubMed

Rubio, L; Alonso, C; Rodríguez, G; Barbosa-Barros, L; Coderch, L; De la Maza, A; Parra, J L; López, O

2010-02-15

This work evaluates the effect of different bicellar systems on the percutaneous absorption of diclofenac diethylamine (DDEA) using two different approaches. In the first case, the drug was included in bicellar systems, which were applied on the skin and, in the second case, the skin was treated by applying bicellar systems without drug before to the application of a DDEA aqueous solution. The characterization of bicellar systems showed that the particle size decreased when DDEA was encapsulated. Percutaneous absorption studies demonstrated a lower penetration of DDEA when the drug was included in bicellar systems than when the drug was applied in an aqueous solution. This effect was possibly due to a certain rigidity of the bicellar systems caused by the incorporation of DDEA. The absorption of DDEA on skin pretreated with bicelles increased compared to the absorption of DDEA on intact skin. Bicelles without DDEA could cause certain disorganization of the SC barrier function, thereby facilitating the percutaneous penetration of DDEA subsequently applied. Thus, depending on their physicochemical parameters and on the application conditions, these systems have potential enhancement or retardant effects on percutaneous absorption that result in an interesting strategy, which may be used in future drug delivery applications. Copyright 2009 Elsevier B.V. All rights reserved.

Simulation of a 20-ton LiBr/H{sub 2}O absorption cooling system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wardono, B.; Nelson, R.M.

The possibility of using solar energy as the main heat input for cooling systems has led to several studies of available cooling technologies that use solar energy. The results show that double-effect absorption cooling systems give relatively high performance. To further study absorption cooling systems, a computer code was developed for a double-effect lithium bromide/water (LiBr/H{sub 2}O) absorption system. To evaluate the performance, two objective functions were developed including the coefficient of performance (COP) and the system cost. Based on the system cost, an optimization to find the minimum cost was performed to determine the nominal heat transfer areas ofmore » each heat exchanger. The nominal values of other system variables, such as the mass flow rates and inlet temperatures of the hot water, cooling water, and chilled water, are specified as commonly used values for commercial machines. The results of the optimization show that there are optimum heat transfer areas. In this study, hot water is used as the main energy input. Using a constant load of 20 tons cooling capacity, the effects of various variables including the heat transfer ares, mass flow rates, and inlet temperatures of hot water, cooling water, and chilled water are presented.« less

Application of finite-element methods to dynamic analysis of flexible spatial and co-planar linkage systems, part 2

NASA Technical Reports Server (NTRS)

Dubowsky, Steven

1989-01-01

An approach is described to modeling the flexibility effects in spatial mechanisms and manipulator systems. The method is based on finite element representations of the individual links in the system. However, it should be noted that conventional finite element methods and software packages will not handle the highly nonlinear dynamic behavior of these systems which results form their changing geometry. In order to design high-performance lightweight systems and their control systems, good models of their dynamic behavior which include the effects of flexibility are required.

Application of lasers and pulsed power to coating removal

NASA Astrophysics Data System (ADS)

Young, Chris M.; Moeny, William M.; Curry, Randy D.; McDonald, Ken; Bosma, John T.

1995-03-01

Lasers and other pulsed power systems are uniquely suited for removal of coatings from a wide variety of substrates. Coatings which can be removed by these systems include paint, adhesives, epoxies, dips, rust, scale, and bird droppings. Suitable substrates include wood, metal, cloth, stone, ceramic, plastics, and even skin. These systems have the advantage over chemical stripping or mechanical abrasion in that the substrate is left virtually unharmed and in many cases the residue is reduced to a form that is more easily disposed of without toxic byproducts or expensive refurbishment. Furthermore, laser and other pulsed power based systems can be operated using only local containment without the need for special operator protective gear or complete enclosure of the substrate structure. Additional advantages are gained in these systems because they typically combine multiple removal mechanisms for greater effectiveness. For example, pulsed lasers create rapid heating of the coating. This rapid heating can result in chemical breakdown of the coating, thermomechanical stress induced dislocation, shock wave agitation, and physical ablation. This paper presents some of the latest research findings on coating removal using these systems. A comparative survey of the system technology, effectiveness, cost, and application is presented. Also presented is a survey of the commercial potential for the systems. Systems which are presented include lasers (CW, pulsed, Infrared, UV, etc.), flashlamps, electro-cathodic debonders, electron beams, and glow discharges.

Computer-Aided Air-Traffic Control In The Terminal Area

NASA Technical Reports Server (NTRS)

Erzberger, Heinz

1995-01-01

Developmental computer-aided system for automated management and control of arrival traffic at large airport includes three integrated subsystems. One subsystem, called Traffic Management Advisor, another subsystem, called Descent Advisor, and third subsystem, called Final Approach Spacing Tool. Data base that includes current wind measurements and mathematical models of performances of types of aircraft contributes to effective operation of system.

Stingray injury.

PubMed Central

Evans, R J; Davies, R S

1996-01-01

A case of stingray injury is reported. Local symptoms and signs include intense pain, oedema around the wound, erythema and petechiae. Systemic symptoms and signs include nausea and vomiting, muscle cramps, diaphoresis, syncope, headache, muscle fasciculations, and cardiac arrhythmias. Treatment aims to reverse local and systemic effects of the venom, alleviate pain, and prevent infection. Antitetanus prophylaxis is important. Treatment for anaphylaxis may be necessary. PMID:8733672

The climate-wildfire-air quality system: interactions and feedbacks across spatial and temporal scales

Treesearch

E. Natasha Stavros; Donald McKenzie; Narasimhan Larkin

2014-01-01

Future climate change and its effects on social and ecological systems present challenges for preserving valued ecosystem services, including local and regional air quality. Wildfire is a major source of air-quality impact in some locations, and a substantial contributor to pollutants of concern, including nitrogen oxides and particulate matter, which are regulated to...

Ab initio effective core potentials including relativistic effects and their application to the electronic structure calculations of heavy atoms and molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Y.S.

1977-11-01

The effects of the 4f shell of electrons and the relativity of valence electrons are compared. The effect of 4f shell (lanthanide contraction) is estimated from the numerical Hartree-Fock (HF) calculations of pseudo-atoms corresponding to Hf, Re, Au, Hg, Tl, Pb and Bi without 4f electrons and with atomic numbers reduced by 14. The relativistic effect estimated from the numerical Dirac-Hartree-Fock (DHF) calculations of those atoms is comparable in the magnitude with that of the 4f shell of electrons. Both are larger for 6s than for 5d or 6p electrons. The various relativistic effects on valence electrons are discussed inmore » detail to determine the proper level of the approximation for the valence electron calculations of systems with heavy elements. An effective core potential system has been developed for heavy atoms in which relativistic effects are included in the effective potentials.« less

Drug Delivery and Nanoformulations for the Cardiovascular System.

PubMed

Geldenhuys, W J; Khayat, M T; Yun, J; Nayeem, M A

2017-02-01

Therapeutic delivery to the cardiovascular system may play an important role in the successful treatment of a variety of disease state, including atherosclerosis, ischemic-reperfusion injury and other types of microvascular diseases including hypertension. In this review we evaluate the different options available for the development of suitable delivery systems that include the delivery of small organic compounds [adenosin A 2A receptor agonist (CGS 21680), CYP-epoxygenases inhibitor (N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide, trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy] benzoic acid), soluble epoxide hydrolase inhibitor (N-methylsulfonyl-12,12-dibromododec-11-enamide), PPARγ agonist (rosiglitazone) and PPARγ antagonist (T0070907)], nanoparticles, peptides, and siRNA to the cardiovascular system. Effective formulations of nanoproducts have significant potential to overcome physiological barriers and improve therapeutic outcomes in patients. As per the literature covering targeted delivery to the cardiovascular system, we found that this area is still at infancy stage, as compare to the more mature fields of tumor cancer or brain delivery (e.g. blood-brain barrier permeability) with fewer publications focused on the targeted drug delivery technologies. Additionally, we show how pharmacology needs to be well understood when considering the cardiovascular system. Therefore, we discussed in this review various receptors agonists, antagonists, activators and inhibitors which will have effects on cardiovascular system.

Prospective relations between family conflict and adolescent maladjustment: security in the family system as a mediating process.

PubMed

Cummings, E Mark; Koss, Kalsea J; Davies, Patrick T

2015-04-01

Conflict in specific family systems (e.g., interparental, parent-child) has been implicated in the development of a host of adjustment problems in adolescence, but little is known about the impact of family conflict involving multiple family systems. Furthermore, questions remain about the effects of family conflict on symptoms of specific disorders and adjustment problems and the processes mediating these effects. The present study prospectively examines the impact of family conflict and emotional security about the family system on adolescent symptoms of specific disorders and adjustment problems, including the development of symptoms of anxiety, depression, conduct problems, and peer problems. Security in the family system was examined as a mediator of these relations. Participants included 295 mother-father-adolescent families (149 girls) participating across three annual time points (grades 7-9). Including auto-regressive controls for initial levels of emotional insecurity and multiple adjustment problems (T1), higher-order emotional insecurity about the family system (T2) mediated relations between T1 family conflict and T3 peer problems, anxiety, and depressive symptoms. Further analyses supported specific patterns of emotional security/insecurity (i.e., security, disengagement, preoccupation) as mediators between family conflict and specific domains of adolescent adjustment. Family conflict was thus found to prospectively predict the development of symptoms of multiple specific adjustment problems, including symptoms of depression, anxiety, conduct problems, and peer problems, by elevating in in adolescent's emotional insecurity about the family system. The clinical implications of these findings are considered.

Columbia River System Operation Review : Final Environmental Impact Statement, Appendix N: Wildlife.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Columbia River System Operation Review

1995-11-01

The Columbia River System is a vast and complex combination of Federal and non-Federal facilities used for many purposes including power production, irrigation, navigation, flood control, recreation, fish and wildlife habitat and municipal and industrial water supply. Each river use competes for the limited water resources in the Columbia River Basin. This technical appendix addresses only the effects of alternative system operating strategies for managing the Columbia River system. The environmental impact statement (EIS) itself and some of the other appendices present analyses of the alternative approaches to the other three decisions considered as part of the SOR. This documentmore » is the product of the Wildlife Work Group, focusing on wildlife impacts but not including fishes. Topics covered include the following: scope and process; existing and affected environment, including specific discussion of 18 projects in the Columbia river basin. Analysis, evaluation, and alternatives are presented for all projects. System wide impacts to wildlife are also included.« less

All Effects of Psychophysical Variables on Color Attributes: A Classification System

PubMed Central

Pridmore, Ralph W.; Melgosa, Manuel

2015-01-01

This paper reports the research and structuring of a classification system for the effects of psychophysical variables on the color attributes. A basic role of color science is to psychophysically specify color appearance. An early stage is to specify the effects of the psychophysical variables (as singles, pairs, etc) on the color attributes (as singles, pairs, etc), for example to model color appearance. Current data on effects are often scarce or conflicting. Few effects are well understood, and the practice of naming effects after their discoverer(s) is inadequate and can be confusing. The number and types of possible effects have never been systematically analyzed and categorized. We propose a simple and rigorous system of classification including nomenclature. The total range of effects is computed from the possible combinations of three psychophysical variables (luminance, dominant wavelength, purity) and six color attributes (lightness, brightness, hue, chroma, colorfulness, saturation) in all modes of appearance. Omitting those effects that are normally impossible to perceive at any one time (such as four- or five-dimensional colors), the total number perceivable is 161 types of effects for all modes of appearance. The type of effect is named after the psychophysical stimulus (or stimuli) and the relevant color attribute(s), e.g., Luminance-on-hue effect (traditionally known as Bezold-Brucke effect). Each type of effect may include slightly different effects with infinite variations depending on experimental parameters. PMID:25859845

Rotor Systems Research Aircraft /RSRA/ canopy explosive severance/fracture

NASA Technical Reports Server (NTRS)

Bement, L. J.

1976-01-01

The Rotor Systems Research Aircraft (RSRA), a compound rotor/fixed-wing aircraft, incorporates an emergency escape system for the three crew members; to achieve unobstructed egress, the overhead acrylic canopies of each crew member will be explosively severed and fractured into predictably small, low-mass pieces. A canopy explosive severance/fracture system was developed under this investigation that included the following system design considerations: selection of canopy and explosive materials, determining the acrylic's explosive severance and fracture characteristics, evaluating the effects of installation variables and temperature, determining the most effective explosive patterns, conducting full-scale, flat and double-curvature canopy tests, and evaluating the effects of back-blast of the explosive into the cockpit.

EPA requirements and programs

NASA Technical Reports Server (NTRS)

Koutsandreas, J. D.

1975-01-01

The proposed ERTS-DCS system is designed to allow EPA the capability to evaluate, through demonstrable hardware, the effectiveness of automated data collection techniques. The total effectiveness of any system is dependent upon many factors which include equipment cost, installation, maintainability, logistic support, growth potential, flexibility and failure rate. This can best be accomplished by installing the system at an operational environmental control agency (CAMP station) to insure that valid data is being obtained and processed. Consequently, it is imperative that the equipment interface must not compromise the validity of the sensor data nor should the experimental system effect the present operations of the CAMP station. Since both the system which is presently in use and the automatic system would be in operation in parallel, conformation and comparison are readily obtained.

Spacecraft surgical scrub system

NASA Technical Reports Server (NTRS)

Abbate, M.

1980-01-01

Ease of handling and control in zero gravity and minimizing the quantity of water required were prime considerations. The program tasks include the selection of biocidal agent from among the variety used for surgical scrub, formulation of a dispensing system, test, and delivery of flight dispensers. The choice of an iodophore was based on effectiveness on single applications, general familiarity among surgeons, and previous qualification for space use. The delivery system was a choice between the squeeze foamer system and impregnated polyurethane foam pads. The impregnated foam pad was recommended because it is a simpler system since the squeeze foamer requires some applicator to effectively clean the skin surfaces, whereas the form pad is the applicator and agent combined. Testing demonstrated that both systems are effective for use as surgical scrubs.

21 CFR 1308.13 - Schedule III.

Code of Federal Regulations, 2011 CFR

2011-04-01

... any quantity of the following substances having a depressant effect on the central nervous system: (1... a stimulant effect on the central nervous sxstem, including its salts, isomers (whether optical...

21 CFR 1308.13 - Schedule III.

Code of Federal Regulations, 2010 CFR

2010-04-01

... any quantity of the following substances having a depressant effect on the central nervous system: (1... a stimulant effect on the central nervous sxstem, including its salts, isomers (whether optical...

Immunological Effects of Probiotics and their Significance to Human Health

NASA Astrophysics Data System (ADS)

Gill, Harsharn S.; Grover, Sunita; Batish, Virender K.; Gill, Preet

Probiotics are defined as live microorganisms which when administered in adequate amounts confer a health benefit upon the host (FAO/WHO, 2001). Lactic acid bacteria, particularly Lactobacillus and Bifidobacterium species are commonly used as probiotics. Other less commonly used probiotics include the yeast Sacchromyces cerevisiae and some non-pathogenic Escherichia coli and Bacillus species. Studies over the past 20 years have demonstrated that probiotic intake is able to confer a range of health benefits including modulation of the immune system, protection against gastrointestinal and respiratory tract infections, lowering of blood cholesterol levels, attenuation of overt immuno-inflammatory disorders (such as inflammatory bowel disease, allergies) and anti-cancer effects. However, the strongest clinical evidence for probiotics relates to their effectiveness in improving gut health and modulating (via stimulation or regulation) the host immune system. This chapter provides an overview of the current status of our knowledge regarding the immunostimulatory and immunoregulatory effects of probiotics on the immune system and their significance to human health.

A solid-state pH sensor for nonaqueous media including ionic liquids.

PubMed

Thompson, Brianna C; Winther-Jensen, Orawan; Winther-Jensen, Bjorn; MacFarlane, Douglas R

2013-04-02

We describe a solid state electrode structure based on a biologically derived proton-active redox center, riboflavin (RFN). The redox reaction of RFN is a pH-dependent process that requires no water. The electrode was fabricated using our previously described 'stuffing' method to entrap RFN into vapor phase polymerized poly(3,4-ethylenedioxythiophene). The electrode is shown to be capable of measuring the proton activity in the form of an effective pH over a range of different water contents including nonaqueous systems and ionic liquids (ILs). This demonstrates that the entrapment of the redox center facilitates direct electron communication with the polymer. This work provides a miniaturizable system to determine pH (effective) in nonaqueous systems as well as in ionic liquids. The ability to measure pH (effective) is an important step toward the ability to customize ILs with suitable pH (effective) for catalytic reactions and biotechnology applications such as protein preservation.

Cervical screening programmes: can automation help? Evidence from systematic reviews, an economic analysis and a simulation modelling exercise applied to the UK.

PubMed

Willis, B H; Barton, P; Pearmain, P; Bryan, S; Hyde, C

2005-03-01

To assess the effectiveness and cost-effectiveness of adding automated image analysis to cervical screening programmes. Searching of all major electronic databases to the end of 2000 was supplemented by a detailed survey for unpublished UK literature. Four systematic reviews were conducted according to recognised guidance. The review of 'clinical effectiveness' included studies assessing reproducibility and impact on health outcomes and processes in addition to evaluations of test accuracy. A discrete event simulation model was developed, although the economic evaluation ultimately relied on a cost-minimisation analysis. The predominant finding from the systematic reviews was the very limited amount of rigorous primary research. None of the included studies refers to the only commercially available automated image analysis device in 2002, the AutoPap Guided Screening (GS) System. The results of the included studies were debatably most compatible with automated image analysis being equivalent in test performance to manual screening. Concerning process, there was evidence that automation does lead to reductions in average slide processing times. In the PRISMATIC trial this was reduced from 10.4 to 3.9 minutes, a statistically significant and practically important difference. The economic evaluation tentatively suggested that the AutoPap GS System may be efficient. The key proviso is that credible data become available to support that the AutoPap GS System has test performance and processing times equivalent to those obtained for PAPNET. The available evidence is still insufficient to recommend implementation of automated image analysis systems. The priority for action remains further research, particularly the 'clinical effectiveness' of the AutoPap GS System. Assessing the cost-effectiveness of introducing automation alongside other approaches is also a priority.

A System to Create Training Systems

ERIC Educational Resources Information Center

Training in Business and Industry, 1971

1971-01-01

This article describes Kodak's procedure for analyzing, developing and pretesting training programs through its Marketing Education Center. Included is a case history of the application of the method which greatly affects cost effectiveness. (RR)

Certification of lightning protection for a full-authority digital engine control

NASA Technical Reports Server (NTRS)

Dargi, M.; Rupke, E.; Wiles, K.

1991-01-01

FADEC systems present many challenges to the lightning protection engineer. Verification of the protection-design adequacy for certification purposes presents additional challenges. The basic requirements of the certification plan of a FADEC is to demonstrate compliance with Federal Airworthiness Regulations (FAR) 25.1309 and 25.581. These FARs are intended for transport aircraft, but there are equivalent sections for general aviation aircraft, normal and transport rotorcraft. Military aircraft may have additional requirements. The criteria for demonstration of adequate lightning protection for a FADEC systems include the procedures outlined in FAA Advisory Circular (AC) 20-136, Protection of aircraft electrical/electronic systems against the indirect effects of lightning. As FADEC systems, including the interconnecting wiring, are generally not susceptible to direct attachment of lightning currents, the verification of protection against indirect effects is primarily described.

Effectiveness of fungicides in protecting Douglas-fir shoots from infection by Phytophthora ramorum

Treesearch

G.A. Chastagner; E.M. Hansen; K.L. Riley; W. Sutton

2006-01-01

The effectiveness of 20 systemic and contact fungicides in protecting Douglas-fir seedlings from infection by Phytophthora ramorum was determined. Some systemic products were applied about a week prior to bud break, while most treatments were applied just after bud break. In addition to the fungicides, two surfactants were included in the post-bud...

Effects of atmospheric CO2 enrichment on soil CO2 efflux in a young longleaf pine system

Treesearch

G. Brett Runion; John R. Butnor; S. A. Prior; R. J. Mitchell; H. H. Rogers

2012-01-01

The southeastern landscape is composed of agricultural and forest systems that can store carbon (C) in standing biomass and soil. Research is needed to quantify the effects of elevated atmospheric carbon dioxide (CO2) on terrestrial C dynamics including CO2 release back to the atmosphere and soil sequestration. Longleaf...

Improving Assessment Processes in Higher Education: Student and Teacher Perceptions of the Effectiveness of a Rubric Embedded in a LMS

ERIC Educational Resources Information Center

Atkinson, Doug; Lim, Siew Leng

2013-01-01

Students and teachers play different roles and thus have different perceptions about the effectiveness of assessment including structure, feedback, consistency, fairness and efficiency. In an undergraduate Business Information Systems course, a rubric was designed and semi-automated through a learning management system (LMS) to provide formative…

Determining the Effectiveness of Alternative Seating Systems for Students with Attention Difficulties: A Systematic Review

ERIC Educational Resources Information Center

Gochenour, Brittany; Poskey, Gail A.

2017-01-01

A student's ability to attend in the classroom is an important factor in determining academic success. This systematic review examined the effects of an alternative seating system on improving attention in students with attention difficulties. Databases searched included CINAHL, Medline, PsycINFO, OTSeeker, Cochrane Library, and Google Scholar.…

Picture Exchange Communication System with Individuals with Developmental Disabilities: A Meta-Analysis of Single Subject Studies

ERIC Educational Resources Information Center

Hart, Stephanie L.; Banda, Devender R.

2010-01-01

Picture Exchange Communication System (PECS) is a picture-based communication strategy used to teach communication skills to persons with developmental disabilities including autism. This article systematically reviews 13 published single-subject studies to examine the effectiveness of PECS, the effects of PECS on speech and problem behaviors,…

The Content, Predictive Power, and Potential Bias in Five Widely Used Teacher Observation Instruments. REL 2017-191

ERIC Educational Resources Information Center

Gill, Brian; Shoji, Megan; Coen, Thomas; Place, Kate

2016-01-01

School districts and states across the Regional Educational Laboratory Mid-Atlantic Region and the country as a whole have been modifying their teacher evaluation systems to identify more effective and less effective teachers and provide better feedback to improve instructional practice. The new systems typically include components related to…

The Effect of a Course Management System (CMS)-Supported Strategy Instruction on EFL Reading Comprehension and Strategy Use

ERIC Educational Resources Information Center

Tsai, Yea-Ru; Talley, Paul C.

2014-01-01

This paper reports on the effect of a Moodle-supported strategy instruction on both reading comprehension and strategy use among EFL (English as a Foreign Language) students. Specific reading strategy training was first integrated into a Moodle system, which included reading exercises on problem identification, monitoring comprehension,…

Enhancing a Socio-technical Data Ecosystem for Societally Relevant, Sustained Arctic Observing

NASA Astrophysics Data System (ADS)

Pulsifer, P. L.

2017-12-01

In recent years, much has been learned about the state of data and related systems for the Arctic region, however work remains to be done to achieve an envisioned integrated and well-defined pan-Arctic observing and data network. The envisioned comprehensive network will enables access to high quality data, expertise and information in support of scientific understanding, stakeholder needs, and agency operations. In this paper we argue that priorities for establishing such a network are in the areas of better understanding the current system, machine-enhanced data discovery and mediation, and the human aspects of community building. The author has engaged extensively in international, Canadian and U.S.-based data coordination and system design efforts. This includes a series of meetings, workshops, systems design activities, and publications. The results of these efforts have been analyzed and a synthesis of these analyses are presented here. Analysis reveals that there are a large number of polar data resources interacting in a complex network that functions as a data ecosystem. Understanding this ecosystem is critical and required to guide design. Given the size and complexity of the network, achieving broad data discovery and access and meaningful data integration will require advanced techniques including machine learning, semantic mediation, and the use of highly connected virtual research environments. To achieve the aforementioned goal will require a community of engaged researchers, technologists, and stakeholders to establish requirements and the social and organizational context needed for effective approaches. The results imply that: i) an effective governance mechanism must be established that includes "bottom up" and "top down" control; ii) the established governance mechanism must include effective networking of actors in the system; iii) funders must adopt a long-term, sustainable infrastructure approach to systems development; iv) best practices will include service and application "chaining" to provide solutions for the diverse Arctic community. Establishing cyberinfrastructure for a sustained Arctic observing network that benefits society will require an innovative combination of emerging technologies and community-building across stakeholders.

The impact of the night float system on internal medicine residency programs.

PubMed

Trontell, M C; Carson, J L; Taragin, M I; Duff, A

1991-01-01

To study the design, method of implementation, perceived benefits, and problems associated with a night float system. Self-administered questionnaire completed by program directors, which included both structured and open-ended questions. The answers reflect resident and student opinions as well as those of the program directors, since program directors regularly obtain feedback from these groups. The 442 accredited internal medicine residency programs listed in the 1988-89 Directory of Graduate Medical Education Programs. Of the 442 programs, 79% responded, and 30% had experience with a night float system. The most frequent methods for initiating a night float system included: decreasing elective time (42.3%), hiring more residents (26.9%), creating a non-teaching service (12.5%), and reallocating housestaff time (9.6%). Positive effects cited include decreased fatigue, improved housestaff morale, improved recruiting, and better attitude toward internal medicine training. The quality of medical care was considered the same or better by most programs using it. The most commonly cited problems were decreased continuity of care, inadequate teaching of the night float team, and miscommunication. Residency programs using a night float system usually observe a positive effect on housestaff morale, recruitment, and working hours and no detrimental effect on the quality of patient care. Miscommunication and inadequate learning experience for the night float team are important potential problems. This survey suggests that the night float represents one solution to reducing resident working hours.

The Effects of Projected Future Demand Including Very Light Jet Air-Taxi Operations on U.S. National Airspace System Delays as a Function of Next Generation Air Transportation System Airspace Capacity

NASA Technical Reports Server (NTRS)

Smith, Jerry; Viken, Jeff; Dollyhigh, Samuel; Trani, Antonio; Baik, Hojong; Hinze, Nicholas; Ashiabor, Senanu

2007-01-01

This paper presents the results from a study which investigates the potential effects of the growth in air traffic demand including projected Very Light Jet (VLJ) air-taxi operations adding to delays experienced by commercial passenger air transportation in the year 2025. The geographic region studied is the contiguous United States (U.S.) of America, although international air traffic to and from the U.S. is included. The main focus of this paper is to determine how much air traffic growth, including VLJ air-taxi operations will add to enroute airspace congestion and determine what additional airspace capacity will be needed to accommodate the expected demand. Terminal airspace is not modeled and increased airport capacity is assumed.

Simulation model of the integrated flight/propulsion control system, displays, and propulsion system for ASTOVL lift-fan aircraft

NASA Technical Reports Server (NTRS)

Chung, W. Y. William; Borchers, Paul F.; Franklin, James A.

1995-01-01

A simulation model has been developed for use in piloted evaluations of takeoff, transition, hover, and landing characteristics of an advanced, short takeoff, vertical landing lift fan fighter aircraft. The flight/propulsion control system includes modes for several response types which are coupled to the aircraft's aerodynamic and propulsion system effectors through a control selector tailored to the lift fan propulsion system. Head-up display modes for approach and hover, tailored to their corresponding control modes are provided in the simulation. Propulsion system components modeled include a remote lift and a lift/cruise engine. Their static performance and dynamic response are represented by the model. A separate report describes the subsonic, power-off aerodynamics and jet induced aerodynamics in hover and forward flight, including ground effects.

Angular velocities, angular accelerations, and coriolis accelerations

NASA Technical Reports Server (NTRS)

Graybiel, A.

1975-01-01

Weightlessness, rotating environment, and mathematical analysis of Coriolis acceleration is described for man's biological effective force environments. Effects on the vestibular system are summarized, including the end organs, functional neurology, and input-output relations. Ground-based studies in preparation for space missions are examined, including functional tests, provocative tests, adaptive capacity tests, simulation studies, and antimotion sickness.

Saint Lawrence Seaway Navigation-Aid System Study : Volume I - Text and Appendixes A and D

DOT National Transportation Integrated Search

1978-09-01

The requirements for a navigation guidance system which will effect an increase in the ship processing capacity of the Saint Lawrence Seaway (Lake Ontario to Montreal, Quebec) are developed. The requirements include a specification of system position...

Time Analysis: Still an Important Accountability Tool.

ERIC Educational Resources Information Center

Fairchild, Thomas N.; Seeley, Tracey J.

1994-01-01

Reviews benefits to school counselors of conducting a time analysis. Describes time analysis system that authors have used, including case illustration of how authors used data to effect counseling program changes. System described followed process outlined by Fairchild: identifying services, devising coding system, keeping records, synthesizing…

75 FR 62436 - Notice of Issuance of Regulatory Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

... Power Plants,'' includes in its scope safety- related structures, systems, and components (SSCs) that... monitor the effectiveness of maintenance for protective coatings within its scope (as discrete systems or... and Management System (ADAMS) under Accession No. ML102230359. Electronic copies of Regulatory Guide 1...

Instrumentation and Automation of Wastewater Collection and Treatment Systems.

ERIC Educational Resources Information Center

Roesler, Joseph F.; Cummins, Michael D.

1978-01-01

Presents a literature review of the use of instrumentation and automation of wastewater treatment systems, covering publications of 1976-77. This review includes automatic control systems and cost effectiveness of automation of wastewater treatment. A list of 115 references is also presented. (HM)

Using an adapted form of the picture exchange communication system to increase independent requesting in deafblind adults with learning disabilities.

PubMed

Bracken, Maeve; Rohrer, Nicole

2014-02-01

The current study assessed the effectiveness of an adapted form of the Picture Exchange Communication System (PECS) in increasing independent requesting in deafblind adults with learning disabilities. PECS cards were created to accommodate individual needs, including adaptations such as enlarging photographs and using swelled images which consisted of images created on raised line drawing paper. Training included up to Phase III of PECS and procedures ensuring generalizations across individuals and contexts were included. The effects of the intervention were evaluated using a multiple baseline design across participants. Results demonstrated an increase in independent requesting with each of the participants reaching mastery criterion. These results suggest that PECS, in combination with some minor adaptations, may be an effective communicative alternative for individuals who are deafblind and have learning impairments. Copyright © 2013 Elsevier Ltd. All rights reserved.

NASA progress in aircraft noise prediction

NASA Technical Reports Server (NTRS)

Raney, J. P.; Padula, S. L.; Zorumski, W. E.

1981-01-01

Langley Research Center efforts to develop a methodology for predicting the effective perceived noise level (EPNL) produced by jet-powered CTOL aircraft to an accuracy of + or - 1.5 dB are summarized with emphasis on the aircraft noise prediction program (ANOPP) which contains a complete set of prediction methods for CTOL aircraft including propulsion system noise sources, aerodynamic or airframe noise sources, forward speed effects, a layered atmospheric model with molecular absorption, ground impedance effects including excess ground attenuation, and a received noise contouring capability. The present state of ANOPP is described and its accuracy and applicability to the preliminary aircraft design process is assessed. Areas are indicated where further theoretical and experimental research on noise prediction are needed. Topics covered include the elements of the noise prediction problem which are incorporated in ANOPP, results of comparisons of ANOPP calculations with measured noise levels, and progress toward treating noise as a design constraint in aircraft system studies.

Effects of hypothyroidism on the respiratory system and control of breathing: Human studies and animal models.

PubMed

Schlenker, Evelyn H

2012-04-30

Hypothyroidism, subclinical hypothyroidism and euthyroid sick syndrome, are prevalent disorders that affect all body systems including the respiratory system and control of breathing. The purpose of this review article is to discuss the regulation of thyroid hormone production and their function at the cellular level; the many causes of hypothyroidism; the effects of hypothyroidism on the respiratory system and on control of ventilation in hypothyroid patients; the variety of ways animal models of hypothyroidism are induced; and how in animal models hypothyroidism affects the respiratory system and control of breathing including neurotransmitters that influence breathing. Finally, this review will present controversies that exist in the field and thus encourage new research directions. Because of the high prevalence of hypothyroidism and subclinical forms of hypothyroidism and their influence on ventilation and the respiratory system, understanding underlying molecular mechanisms is necessary to ascertain how and sometimes why not thyroid replacement may normalize function. Copyright © 2012 Elsevier B.V. All rights reserved.

I.C.I.S. Inter-Campus Information System.

ERIC Educational Resources Information Center

Alvir, Howard P.

A decision making system for educators to enable them to plan and make information-based decisions is briefly described. The information system's characteristics are explained, along with a summary of information systems in higher education. A self-test criteria of effectiveness and feedback and evaluation methods are also included. A request form…

Modeling Spring Mass System with System Dynamics Approach in Middle School Education

ERIC Educational Resources Information Center

Nuhoglu, Hasret

2008-01-01

System Dynamics is a well formulated methodology for analyzing the components of a system including cause-effect relationships and their underlying mathematics and logic, time delays, and feedback loops. It began in the business and manufacturing world, but is now affecting education and many other disciplines. Having inspired by successful policy…

Assessment of Alternative Student Aid Delivery Systems: Assessment of the Current Delivery System.

ERIC Educational Resources Information Center

Advanced Technology, Inc., Reston, VA.

The effects of the current system for delivering federal financial assistance to students under the Pell Grant, Guaranteed Student Loan (GSL), and campus-based programs are analyzed. Information is included on the use of the assessment model, which combines program evaluation, systems research, and policy analysis methodologies.…

Capturing reimbursement for advanced practice nurse services in acute and critical care: legal and business considerations.

PubMed

Buppert, Carolyn

2005-01-01

Advanced practice nurses (APNs) have been affected positively and negatively by recent changes in the way hospitals are financed. Among these changes are the shift from cost-based reimbursement to a prospective payment system and increased opportunities for billing APN services under the physician payment system. Positive effects include the need for hospitals to decrease the length of stay of hospitalized patients, leading to jobs for APNs who make the hospital course and discharge more efficient. Negative effects include budget shortfalls that lead to layoffs. This article explains the current financial landscape, including phenomena that are impeding the billing of APN services, and recommends adjustments so that the APN role will be on firm financial footing.

Cost effectiveness as applied to the Viking Lander systems-level thermal development test program

NASA Technical Reports Server (NTRS)

Buna, T.; Shupert, T. C.

1974-01-01

The economic aspects of thermal testing at the systems-level as applied to the Viking Lander Capsule thermal development program are reviewed. The unique mission profile and pioneering scientific goals of Viking imposed novel requirements on testing, including the development of a simulation technique for the Martian thermal environment. The selected approach included modifications of an existing conventional thermal vacuum facility, and improved test-operational techniques that are applicable to the simulation of the other mission phases as well, thereby contributing significantly to the cost effectiveness of the overall thermal test program.

NALNET book system: Cost benefit study

NASA Technical Reports Server (NTRS)

Dewath, N. V.; Palmour, V. E.; Foley, J. R.; Henderson, M. M.; Shockley, C. W.

1981-01-01

The goals of the NASA's library network system, NALNET, the functions of the current book system, the products and services of a book system required by NASA Center libraries, and the characteristics of a system that would best supply those products and services were assessed. Emphasis was placed on determining the most cost effective means of meeting NASA's requirements for an automated book system. Various operating modes were examined including the current STIMS file, the PUBFILE, developing software improvements for products as appropriate to the Center needs, and obtaining cataloging and products from the bibliographic utilities including at least OCLC, RLIN, BNA, and STIF. It is recommended that NALNET operate under the STIMS file mode and obtain cataloging and products from the bibliographic utilities. The recommendations are based on the premise that given the current state of the art in library automation it is not cost effective for NASA to maintain a full range of cataloging services on its own system. The bibliographic utilities can support higher quality systems with a greater range of services at a lower total cost.

Effects of New Technologies.

ERIC Educational Resources Information Center

Social and Labour Bulletin, 1980

1980-01-01

Transnational implications of technological change and innovation in telecommunications are discussed, including impact on jobs and industrial relations, computer security, access to information, and effects of technological innovation on international economic systems. (SK)

Radiation 101: Effects on Hardware and Robotic Systems

NASA Technical Reports Server (NTRS)

Pellish, Jonathan A.

2015-01-01

We present basic information on different types of radiation effects, including total ionizing dose, displacement damage, and single-event effects. The content is designed to educate space weather professionals, space operations professionals, and other science and engineering stakeholders.

Incorporation of Electrical Systems Models Into an Existing Thermodynamic Cycle Code

NASA Technical Reports Server (NTRS)

Freeh, Josh

2003-01-01

Integration of entire system includes: Fuel cells, motors, propulsors, thermal/power management, compressors, etc. Use of existing, pre-developed NPSS capabilities includes: 1) Optimization tools; 2) Gas turbine models for hybrid systems; 3) Increased interplay between subsystems; 4) Off-design modeling capabilities; 5) Altitude effects; and 6) Existing transient modeling architecture. Other factors inclde: 1) Easier transfer between users and groups of users; 2) General aerospace industry acceptance and familiarity; and 3) Flexible analysis tool that can also be used for ground power applications.

Intelligent systems technology infrastructure for integrated systems

NASA Technical Reports Server (NTRS)

Lum, Henry, Jr.

1991-01-01

Significant advances have occurred during the last decade in intelligent systems technologies (a.k.a. knowledge-based systems, KBS) including research, feasibility demonstrations, and technology implementations in operational environments. Evaluation and simulation data obtained to date in real-time operational environments suggest that cost-effective utilization of intelligent systems technologies can be realized for Automated Rendezvous and Capture applications. The successful implementation of these technologies involve a complex system infrastructure integrating the requirements of transportation, vehicle checkout and health management, and communication systems without compromise to systems reliability and performance. The resources that must be invoked to accomplish these tasks include remote ground operations and control, built-in system fault management and control, and intelligent robotics. To ensure long-term evolution and integration of new validated technologies over the lifetime of the vehicle, system interfaces must also be addressed and integrated into the overall system interface requirements. An approach for defining and evaluating the system infrastructures including the testbed currently being used to support the on-going evaluations for the evolutionary Space Station Freedom Data Management System is presented and discussed. Intelligent system technologies discussed include artificial intelligence (real-time replanning and scheduling), high performance computational elements (parallel processors, photonic processors, and neural networks), real-time fault management and control, and system software development tools for rapid prototyping capabilities.

Radiation protection for manned space activities

NASA Technical Reports Server (NTRS)

Jordan, T. M.

1983-01-01

The Earth's natural radiation environment poses a hazard to manned space activities directly through biological effects and indirectly through effects on materials and electronics. The following standard practices are indicated that address: (1) environment models for all radiation species including uncertainties and temporal variations; (2) upper bound and nominal quality factors for biological radiation effects that include dose, dose rate, critical organ, and linear energy transfer variations; (3) particle transport and shielding methodology including system and man modeling and uncertainty analysis; (4) mission planning that includes active dosimetry, minimizes exposure during extravehicular activities, subjects every mission to a radiation review, and specifies operational procedures for forecasting, recognizing, and dealing with large solar flaes.

Measuring effectiveness of electronic medical records systems: towards building a composite index for benchmarking hospitals.

PubMed

Otieno, George Ochieng; Hinako, Toyama; Motohiro, Asonuma; Daisuke, Koide; Keiko, Naitoh

2008-10-01

Many hospitals are currently in the process of developing and implementing electronic medical records (EMR) systems. This is a critical time for developing a framework that can measure and allow for comparison the effectiveness of EMR systems across hospitals that have implemented these systems. The motivation for this study comes from the realization that there is limited research on the understanding of the effectiveness of EMR systems, and a lack of appropriate reference theoretical framework for measuring the effectiveness of EMR systems. In this paper, we propose a conceptual framework for generating a composite index (CI) for measuring the effectiveness of EMR systems in hospitals. Data used to test the framework and associated research objectives were derived from a cross-sectional survey of five stakeholders of EMR systems including chief medical officers, chief nursing officers, chief information officers, doctors and nurses in 20 Japanese hospitals. Using statistical means of standardization and principal component analysis (PCA) procedure, CI was developed by summing up the scores of four dimensions-system quality, information quality, use and user satisfaction. The process included formulating items for each dimension, condensing the data into factors relevant to the dimension and calculating the CI by summing up the product of each dimension with its respective principal component score coefficient. The Cronbach's alpha for the four dimensions used in developing CI was .843. Validation of CI revealed that it was correlated to internal dimensions (system quality, R=.828; information quality, R=.909; use, R=.969; and user satisfaction, R=.679) and to external factors (JAHIS level, R=.832 and patient safety culture, R=.585). These results suggest that CI could be a reliable and valid measure of the effectiveness of EMR systems in the responding hospitals. On benchmarking of hospitals, 30.0% (6/20) of the responding hospitals performed less than satisfactory on CI and that majority of the hospitals performed poorly on user satisfaction. CI has provided a standard way, through quantitative means, of measuring, comparing and categorizing the effectiveness of EMR systems in hospitals. CI can be a powerful tool for benchmarking the effectiveness of EMR systems in hospitals in ways that can guide hospitals in computerization process as well as benchmark their systems against other hospitals.

Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review

PubMed Central

Wang, Huiying; Lee, In-Seon; Braun, Christoph; Enck, Paul

2016-01-01

To systematically review the effects of probiotics on central nervous system function in animals and humans, to summarize effective interventions (species of probiotic, dose, duration), and to analyze the possibility of translating preclinical studies. Literature searches were conducted in Pubmed, Medline, Embase, and the Cochrane Library. Only randomized controlled trials were included. In total, 38 studies were included: 25 in animals and 15 in humans (2 studies were conducted in both). Most studies used Bifidobacterium (eg, B. longum, B. breve, and B. infantis) and Lactobacillus (eg, L. helveticus, and L. rhamnosus), with doses between 109 and 1010 colony-forming units for 2 weeks in animals and 4 weeks in humans. These probiotics showed efficacy in improving psychiatric disorder-related behaviors including anxiety, depression, autism spectrum disorder (ASD), obsessive-compulsive disorder, and memory abilities, including spatial and non-spatial memory. Because many of the basic science studies showed some efficacy of probiotics on central nervous system function, this background may guide and promote further preclinical and clinical studies. Translating animal studies to human studies has obvious limitations but also suggests possibilities. Here, we provide several suggestions for the translation of animal studies. More experimental designs with both behavioral and neuroimaging measures in healthy volunteers and patients are needed in the future. PMID:27413138

Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review.

PubMed

Wang, Huiying; Lee, In-Seon; Braun, Christoph; Enck, Paul

2016-10-30

To systematically review the effects of probiotics on central nervous system function in animals and humans, to summarize effective interventions (species of probiotic, dose, duration), and to analyze the possibility of translating preclinical studies. Literature searches were conducted in Pubmed, Medline, Embase, and the Cochrane Library. Only randomized controlled trials were included. In total, 38 studies were included: 25 in animals and 15 in humans (2 studies were conducted in both). Most studies used Bifidobacterium (eg, B. longum , B. breve , and B. infantis ) and Lactobacillus (eg, L. helveticus , and L. rhamnosus ), with doses between 10⁸ and 10¹⁰ colony-forming units for 2 weeks in animals and 4 weeks in humans. These probiotics showed efficacy in improving psychiatric disorder-related behaviors including anxiety, depression, autism spectrum disorder (ASD), obsessive-compulsive disorder, and memory abilities, including spatial and non-spatial memory. Because many of the basic science studies showed some efficacy of probiotics on central nervous system function, this background may guide and promote further preclinical and clinical studies. Translating animal studies to human studies has obvious limitations but also suggests possibilities. Here, we provide several suggestions for the translation of animal studies. More experimental designs with both behavioral and neuroimaging measures in healthy volunteers and patients are needed in the future.

Non-targeted effects of ionizing radiation–implications for low dose risk

PubMed Central

Kadhim, Munira; Salomaa, Sisko; Wright, Eric; Hildebrandt, Guido; Belyakov, Oleg V.; Prise, Kevin M.; Little, Mark P.

2014-01-01

Non-DNA targeted effects of ionizing radiation, which include genomic instability, and a variety of bystander effects including abscopal effects and bystander mediated adaptive response, have raised concerns about the magnitude of low-dose radiation risk. Genomic instability, bystander effects and adaptive responses are powered by fundamental, but not clearly understood systems that maintain tissue homeostasis. Despite excellent research in this field by various groups, there are still gaps in our understanding of the likely mechanisms associated with non-DNA targeted effects, particularly with respect to systemic (human health) consequences at low and intermediate doses of ionizing radiation. Other outstanding questions include links between the different non-targeted responses and the variations in response observed between individuals and cell lines, possibly a function of genetic background. Furthermore, it is still not known what the initial target and early interactions in cells are that give rise to non-targeted responses in neighbouring or descendant cells. This paper provides a commentary on the current state of the field as a result of the Non-targeted effects of ionizing radiation (NOTE) Integrated Project funded by the European Union. Here we critically examine the evidence for non-targeted effects, discuss apparently contradictory results and consider implications for low-dose radiation health effects. PMID:23262375

Development of an Instrument for Assessing the Effectiveness of Chemistry Classroom Teaching

NASA Astrophysics Data System (ADS)

Zheng, Changlong; Fu, Lihai; He, Peng

2014-04-01

Classroom teaching is a main frontier of the implementation of new curricular ideas in China. The study reported in this article is concerned with the effectiveness of system of classroom teaching (SCT) in chemistry lessons. According to the Systems Science theory, we took a macroscopic view on the SCT, arguing that SCT is a hierarchy of system, which includes class system, plate system, unit system, and primitive system. In this study, we focused on primitive system of classroom teaching (PrS)—the lowest level in a SCT. Using focus group interviews, this study investigated the variables related to the effectiveness of PrS. We found a total of 21 such variables. To identify the main factors underlying the effectiveness of PrS, we further used exploratory factor analysis and confirmatory factor analysis. We found five main factors: rational use of time, quality of teaching behavior chain, match degree, quality of using resource and technology, and rationality of primitive content. Based on these findings, we constructed an evaluation scale for assessing the effectiveness of primitive system of chemistry classroom teaching.

Effect of space flight on cytokine production

NASA Astrophysics Data System (ADS)

Sonnenfeld, Gerald

Space flight has been shown to alter many immunological responses. Among those affected are the production of cytokines, Cytokines are the messengers of the immune system that facilitate communication among cells that allow the interaction among cells leading to the development of immune responses. Included among the cytokines are the interferons, interleukins, and colony stimulating factors. Cytokines also facilitate communication between the immune system and other body systems, such as the neuroendocrine and musculoskeletal systems. Some cytokines also have direct protective effects on the host, such as interferon, which can inhibit the replication of viruses. Studies in both humans and animals indicate that models of space flight as well as actual space flight alter the production and action of cytokines. Included among these changes are altered interferon production, altered responsiveness of bone marrow cells to granulocyte/monocyte-colony stimulating factor, but no alteration in the production of interleukin-3. This suggests that there are selective effects of space flight on immune responses, i.e. not all cytokines are affected in the same fashion by space flight. Tissue culture studies also suggest that there may be direct effects of space flight on the cells responsible for cytokine production and action. The results of the above study indicate that the effects of space flight on cytokines may be a fundamental mechanism by which space flight not only affects immune responses, but also other biological systems of the human.

[Vitamins and oxidative stress].

PubMed

Kodentsova, V M; Vrzhesinskaia, O A; Mazo, V K

2013-01-01

The central and local stress limiting systems, including the antioxidant defense system involved in defending the organism at the cellular and systemic levels from excess activation response to stress influence, leading to damaging effects. The development of stress, regardless of its nature [cold, increased physical activity, aging, the development of many pathologies (cardiovascular, neurodegenerative diseases, diseases of the gastrointestinal tract, ischemia, the effects of burns), immobilization, hypobaric hypoxia, hyperoxia, radiation effects etc.] leads to a deterioration of the vitamin status (vitamins E, A, C). Damaging effect on the antioxidant defense system is more pronounced compared to the stress response in animals with an isolated deficiency of vitamins C, A, E, B1 or B6 and the combined vitamins deficiency in the diet. Addition missing vitamin or vitamins restores the performance of antioxidant system. Thus, the role of vitamins in adaptation to stressors is evident. However, vitamins C, E and beta-carotene in high doses, significantly higher than the physiological needs of the organism, may be not only antioxidants, but may have also prooxidant properties. Perhaps this explains the lack of positive effects of antioxidant vitamins used in extreme doses for a long time described in some publications. There is no doubt that to justify the current optimal doses of antioxidant vitamins and other dietary antioxidants specially-designed studies, including biochemical testing of initial vitamin and antioxidant status of the organism, as well as monitoring their change over time are required.

Effects of Climate Change on Volcanic Emissions and Health Security in Hawaii by 2050

DTIC Science & Technology

2017-08-01

pulmonary edema (fluid in the lungs), and acute respiratory distress syndrome (ARDS) (Weinstein et al 2013). Acute symptoms increase as SO2 levels and/or...vulnerable populations (Longo et al 2010). At high concentrations, the acute systemic effects of SO2 include: upper airway irritation, pneumonitis...Hydrogen sulfide (H2S) causes cough, shortness of breath and pulmonary edema. At high frequency inhalation, the acute systemic effects of fluoride

Adding signals to coordinated traffic signal systems.

DOT National Transportation Integrated Search

1983-08-01

The purpose of this research was to investigate the effect of adding or : removing traffic signals within a coordinated, signal-controlled street network. : The report includes a discussion of coordinated signal systems; arterial street : network con...

Design, Fabrication and Evaluation of Prototype Wayside Brake Inspection Sensors

DOT National Transportation Integrated Search

1980-06-01

Prototype Wayside instrumentation has been designed, developed, and tested that proves the feasibility of measuring braking system effectiveness on moving rail cars. The instrumentation system includes a specially designed short section of instrument...

Designing Bioretention Systems to Improve Nitrogen Removal

EPA Science Inventory

Bioretention systems effectively remove many stormwater stressors, including oil/grease, heavy metals, phosphorus, and ammonium. However, reported nitrate removal performance is highly variable. Bioretention media is typically coarse-grained with low organic matter content, which...

Prolong Your Roof's Performance: Roof Asset Management.

ERIC Educational Resources Information Center

Teitsma, Jerry

2001-01-01

Discusses the roof asset management process for maintaining a roof system's integrity and value in a cost-effective manner. Included is a breakdown of roofing surface characteristics for multiply and single ply roofing systems. (GR)

Drug effects on neuroendocrine regulation; Proceedings of the International Symposium, Snowmass-at-Aspen, Colo., July 17-19, 1972

NASA Technical Reports Server (NTRS)

Zimmermann, E. (Editor); Gispen, W. H.; Marks, B. H.; De Wied, D.

1973-01-01

Subjects related to the characterization of neuroendocrine systems are discussed, taking into account the need for the precise identification and rigorous description of their operations. Steroid effects on neuroendocrine system performance are considered along with biogenic amine effects on neuroendocrine systems and the influence of drugs of abuse on neuroendocrine behavior. Other topics explored include pituitary-adrenal influences on avoidance and approach behavior of the rat, the adrenocortical mediation of the effects of early life experiences, and the implication of noradrenaline in avoidance learning in the rat. Individual items are announced in this issue.

Effects of electronic excitation on cascade dynamics in nickel–iron and nickel–palladium systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zarkadoula, Eva; Samolyuk, German; Weber, William J.

Using molecular dynamics simulations and the two-temperature model, we provide in this paper a comparison of the surviving damage from single ion irradiation events in nickel-based alloys, for cascades with and without taking into account the effects of the electronic excitations. We find that including the electronic effects impacts the amount of the resulting damage and the production of isolated defects. Finally, irradiation of nickel–palladium systems results in larger numbers of defects compared to nickel–iron systems, with similar numbers of isolated defects. We additionally investigate the mass effect on the two-temperature model in molecular dynamics simulations of cascades.

Effects of electronic excitation on cascade dynamics in nickel–iron and nickel–palladium systems

DOE PAGES

Zarkadoula, Eva; Samolyuk, German; Weber, William J.

2017-06-10

Using molecular dynamics simulations and the two-temperature model, we provide in this paper a comparison of the surviving damage from single ion irradiation events in nickel-based alloys, for cascades with and without taking into account the effects of the electronic excitations. We find that including the electronic effects impacts the amount of the resulting damage and the production of isolated defects. Finally, irradiation of nickel–palladium systems results in larger numbers of defects compared to nickel–iron systems, with similar numbers of isolated defects. We additionally investigate the mass effect on the two-temperature model in molecular dynamics simulations of cascades.

78 FR 76897 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... public comment is received, the amended system will become effective January 21, 2014. ADDRESSES: Written...-reported income with the Internal Revenue Service (IRS) and Social Security Administration (SSA). The... category of records in the system includes: Federal Tax Information (FTI) and social security information...

Development of a School Leadership Evaluation System

ERIC Educational Resources Information Center

Orlando, Nik

2014-01-01

This action research study examined the effectiveness of the process implemented by Partnerships to Uplift Communities (PUC) Schools Charter Management Organization to develop their school leader evaluation system in collaboration with current PUC school leaders. The development of the leadership evaluation system included the collective voices of…

Development of the CODER System: A Testbed for Artificial Intelligence Methods in Information Retrieval.

ERIC Educational Resources Information Center

Fox, Edward A.

1987-01-01

Discusses the CODER system, which was developed to investigate the application of artificial intelligence methods to increase the effectiveness of information retrieval systems, particularly those involving heterogeneous documents. Highlights include the use of PROLOG programing, blackboard-based designs, knowledge engineering, lexicological…

Achieving cost reductions in EOSDIS operations through technology evolution

NASA Technical Reports Server (NTRS)

Newsome, Penny; Moe, Karen; Harberts, Robert

1996-01-01

The earth observing system (EOS) data information system (EOSDIS) mission includes the cost-effective management and distribution of large amounts of data to the earth science community. The effect of the introduction of new information system technologies on the evolution of EOSDIS is considered. One of the steps taken by NASA to enable the introduction of new information system technologies into the EOSDIS is the funding of technology development through prototyping. Recent and ongoing prototyping efforts and their potential impact on the performance and cost-effectiveness of the EOSDIS are discussed. The technology evolution process as it related to the effective operation of EOSDIS is described, and methods are identified for the support of the transfer of relevant technology to EOSDIS components.

Stretching the stress boundary: Linking air pollution health effects to a neurohormonal stress response.

PubMed

Kodavanti, Urmila P

2016-12-01

Inhaled pollutants produce effects in virtually all organ systems in our body and have been linked to chronic diseases including hypertension, atherosclerosis, Alzheimer's and diabetes. A neurohormonal stress response (referred to here as a systemic response produced by activation of the sympathetic nervous system and hypothalamus-pituitary-adrenal (HPA)-axis) has been implicated in a variety of psychological and physical stresses, which involves immune and metabolic homeostatic mechanisms affecting all organs in the body. In this review, we provide new evidence for the involvement of this well-characterized neurohormonal stress response in mediating systemic and pulmonary effects of a prototypic air pollutant - ozone. A plethora of systemic metabolic and immune effects are induced in animals exposed to inhaled pollutants, which could result from increased circulating stress hormones. The release of adrenal-derived stress hormones in response to ozone exposure not only mediates systemic immune and metabolic responses, but by doing so, also modulates pulmonary injury and inflammation. With recurring pollutant exposures, these effects can contribute to multi-organ chronic conditions associated with air pollution. This review will cover, 1) the potential mechanisms by which air pollutants can initiate the relay of signals from respiratory tract to brain through trigeminal and vagus nerves, and activate stress responsive regions including hypothalamus; and 2) the contribution of sympathetic and HPA-axis activation in mediating systemic homeostatic metabolic and immune effects of ozone in various organs. The potential contribution of chronic environmental stress in cardiovascular, neurological, reproductive and metabolic diseases, and the knowledge gaps are also discussed. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Published by Elsevier B.V.

Reducing model uncertainty effects in flexible manipulators through the addition of passive damping

NASA Technical Reports Server (NTRS)

Alberts, T. E.

1987-01-01

An important issue in the control of practical systems is the effect of model uncertainty on closed loop performance. This is of particular concern when flexible structures are to be controlled, due to the fact that states associated with higher frequency vibration modes are truncated in order to make the control problem tractable. Digital simulations of a single-link manipulator system are employed to demonstrate that passive damping added to the flexible member reduces adverse effects associated with model uncertainty. A controller was designed based on a model including only one flexible mode. This controller was applied to larger order systems to evaluate the effects of modal truncation. Simulations using a Linear Quadratic Regulator (LQR) design assuming full state feedback illustrate the effect of control spillover. Simulations of a system using output feedback illustrate the destabilizing effect of observation spillover. The simulations reveal that the system with passive damping is less susceptible to these effects than the untreated case.

BMP analysis system for watershed-based stormwater management.

PubMed

Zhen, Jenny; Shoemaker, Leslie; Riverson, John; Alvi, Khalid; Cheng, Mow-Soung

2006-01-01

Best Management Practices (BMPs) are measures for mitigating nonpoint source (NPS) pollution caused mainly by stormwater runoff. Established urban and newly developing areas must develop cost effective means for restoring or minimizing impacts, and planning future growth. Prince George's County in Maryland, USA, a fast-growing region in the Washington, DC metropolitan area, has developed a number of tools to support analysis and decision making for stormwater management planning and design at the watershed level. These tools support watershed analysis, innovative BMPs, and optimization. Application of these tools can help achieve environmental goals and lead to significant cost savings. This project includes software development that utilizes GIS information and technology, integrates BMP processes simulation models, and applies system optimization techniques for BMP planning and selection. The system employs the ESRI ArcGIS as the platform, and provides GIS-based visualization and support for developing networks including sequences of land uses, BMPs, and stream reaches. The system also provides interfaces for BMP placement, BMP attribute data input, and decision optimization management. The system includes a stand-alone BMP simulation and evaluation module, which complements both research and regulatory nonpoint source control assessment efforts, and allows flexibility in the examining various BMP design alternatives. Process based simulation of BMPs provides a technique that is sensitive to local climate and rainfall patterns. The system incorporates a meta-heuristic optimization technique to find the most cost-effective BMP placement and implementation plan given a control target, or a fixed cost. A case study is presented to demonstrate the application of the Prince George's County system. The case study involves a highly urbanized area in the Anacostia River (a tributary to Potomac River) watershed southeast of Washington, DC. An innovative system of management practices is proposed to minimize runoff, improve water quality, and provide water reuse opportunities. Proposed management techniques include bioretention, green roof, and rooftop runoff collection (rain barrel) systems. The modeling system was used to identify the most cost-effective combinations of management practices to help minimize frequency and size of runoff events and resulting combined sewer overflows to the Anacostia River.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liss, W.; Dybel, M.; West, R.

This report covers the first year's work performed by the Gas Technology Institute and Encorp Inc. under subcontract to the National Renewable Energy Laboratory. The objective of this three-year contract is to develop innovative grid interconnection and control systems. This supports the advancement of distributed generation in the marketplace by making installations more cost-effective and compatible across the electric power and energy management systems. Specifically, the goals are: (1) To develop and demonstrate cost-effective distributed power grid interconnection products and software and communication solutions applicable to improving the economics of a broad range of distributed power systems, including existing, emerging,more » and other power generation technologies. (2) To enhance the features and capabilities of distributed power products to integrate, interact, and provide operational benefits to the electric power and advanced energy management systems. This includes features and capabilities for participating in resource planning, the provision of ancillary services, and energy management. Specific topics of this report include the development of an advanced controller, a power sensing board, expanded communication capabilities, a revenue-grade meter interface, and a case study of an interconnection distributed power system application that is a model for demonstrating the functionalities of the design of the advanced controller.« less

Cavitation guide for control valves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tullis, J.P.

1993-04-01

This guide teaches the basic fundamentals of cavitation to provide the reader with an understanding of what causes cavitation, when it occurs, and the potential problems cavitation can cause to a valve and piping system. The document provides guidelines for understanding how to reduce the cavitation and/or select control valves for a cavitating system. The guide provides a method for predicting the cavitation intensity of control valves, and how the effect of cavitation on a system will vary with valve type, valve function, valve size, operating pressure, duration of operation and details of the piping installation. The guide defines sixmore » cavitation limits identifying cavitation intensities ranging from inception to the maximum intensity possible. The intensity of the cavitation at each limit Is described, including a brief discussion of how each level of cavitation influences the valve and system. Examples are included to demonstrate how to apply the method, including making both size and pressure scale effects corrections. Methods of controlling cavitation are discussed providing information on various techniques which can be used to design a new system or modify an existing one so it can operate at a desired level of cavitation.« less

Applying Data Mining Principles to Library Data Collection.

ERIC Educational Resources Information Center

Guenther, Kim

2000-01-01

Explains how libraries can use data mining techniques for more effective data collection. Highlights include three phases: data selection and acquisition; data preparation and processing, including a discussion of the use of XML (extensible markup language); and data interpretation and integration, including database management systems. (LRW)

Multidimensional System Analysis of Electro-Optic Sensors with Sampled Deterministic Output.

DTIC Science & Technology

1987-12-18

System descriptions of scanning and staring electro - optic sensors with sampled output are developed as follows. Functions representing image...to complete the system descriptions. The results should be useful for designing electro - optic sensor systems and correcting data for instrumental...effects and other experimental conditions. Keywords include: Electro - optic system analysis, Scanning sensors, Staring sensors, Spatial sampling, and Temporal sampling.

Are Integrated Portfolio Systems the Answer? An Evaluation of a Web-Based Portfolio System to Improve Preservice Teachers' Reflective Thinking Skills

ERIC Educational Resources Information Center

Oner, Diler; Adadan, Emine

2016-01-01

This study investigated the effectiveness of an integrated web-based portfolio system, namely the BOUNCE System, which primarily focuses on improving preservice teachers' reflective thinking skills. BOUNCE©, the software component of the system, was designed and developed to support a teaching practice model including a cycle of activities to be…

Management of radioactive waste gases from PET radiopharmaceutical synthesis using cost effective capture systems integrated with a cyclotron safety system.

PubMed

Stimson, D H R; Pringle, A J; Maillet, D; King, A R; Nevin, S T; Venkatachalam, T K; Reutens, D C; Bhalla, R

2016-09-01

The emphasis on the reduction of gaseous radioactive effluent associated with PET radiochemistry laboratories has increased. Various radioactive gas capture strategies have been employed historically including expensive automated compression systems. We have implemented a new cost-effective strategy employing gas capture bags with electronic feedback that are integrated with the cyclotron safety system. Our strategy is suitable for multiple automated 18 F radiosynthesis modules and individual automated 11 C radiosynthesis modules. We describe novel gas capture systems that minimize the risk of human error and are routinely used in our facility.

Research planning criteria for regenerative life-support systems applicable to space habitats

NASA Technical Reports Server (NTRS)

Spurlock, J.; Cooper, W.; Deal, P.; Harlan, A.; Karel, M.; Modell, M.; Moe, P.; Phillips, J.; Putnam, D.; Quattrone, P.

1979-01-01

The second phase of analyses that were conducted by the Life Support Systems Group of the 1977 NASA Ames Summer Study is described. This phase of analyses included a preliminary review of relevant areas of technology that can contribute to the development of closed life-support systems for space habitats, the identification of research options in these areas of technology, and the development of guidelines for an effective research program. The areas of technology that were studied included: (1) nutrition, diet, and food processing; (2) higher plant agriculture; (3) animal agriculture; (4) waste conversion and resource recovery; and (5) system stability and safety. Results of these analyses, including recommended research options and criteria for establishing research priorities among these many options, are discussed.

The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic Review.

PubMed

Elshafay, Abdelrahman; Truong, Duy Hieu; AboElnas, Mohamed M; Idrees, Hossam; Metwali, Hatem G; Vuong, Nguyen Lam; Saad, Omar Ahmed; Hirayama, Kenji; Huy, Nguyen Tien

2018-04-01

The efficacy of endothelin receptor antagonists (ERAs) in the management of Eisenmenger syndrome (ES) remains controversial. The aim of this study is to systemically review the safety and effects of ERAs in improving the quality of life and basic cardiac functions of these patients. Twelve databases were searched, including PubMed, Web of Science, Scopus, Virtual Health Library, World Health Organization (WHO) Global Health Library, Google Scholar, POPLINE, Systems for Information of Grey Literature in Europe, New York Academy of Medicine, ClinicalTrials.gov, metaRegister of Controlled Trials and the WHO International Clinical Trials Registry Platform, through August 2016. We included randomized clinical trials addressing the effect of ERAs on cardiac functions in patients with ES. The quality of studies was assessed using the Cochrane Collaboration tool. We included two trials represented by four papers, of which three papers reported the efficacy of bosentan against placebo and one paper reported the results of a combination of bosentan and sildenafil versus placebo and bosentan. One trial showed a significant effect of bosentan treatment over placebo on indexed pulmonary vascular resistance and mean pulmonary artery pressure, but a non-significant increase in 6-min walk distance and a non-significant effect on systemic pulse oximetry. The other trial reported the safe but non-significant effect of combination therapy of bosentan and sildenafil compared with bosentan and placebo. This study demonstrated safety and improved hemodynamic effects of bosentan in ES, with a controversial effect on exercise capacity. Further randomized controlled trials with longer follow-up duration are needed to confirm these results.

Tracking the deployment of the integrated metropolitan intelligent transportation systems infrastructure in the USA : FY 1997 results

DOT National Transportation Integrated Search

2002-01-01

The essence of effective environmental justice practice is summarized in three fundamental principles: (1) Avoid, minimize, or mitigate disproportionately high and adverse human health and environmental effects, including social and economic effects,...

Power maximization of variable-speed variable-pitch wind turbines using passive adaptive neural fault tolerant control

NASA Astrophysics Data System (ADS)

Habibi, Hamed; Rahimi Nohooji, Hamed; Howard, Ian

2017-09-01

Power maximization has always been a practical consideration in wind turbines. The question of how to address optimal power capture, especially when the system dynamics are nonlinear and the actuators are subject to unknown faults, is significant. This paper studies the control methodology for variable-speed variable-pitch wind turbines including the effects of uncertain nonlinear dynamics, system fault uncertainties, and unknown external disturbances. The nonlinear model of the wind turbine is presented, and the problem of maximizing extracted energy is formulated by designing the optimal desired states. With the known system, a model-based nonlinear controller is designed; then, to handle uncertainties, the unknown nonlinearities of the wind turbine are estimated by utilizing radial basis function neural networks. The adaptive neural fault tolerant control is designed passively to be robust on model uncertainties, disturbances including wind speed and model noises, and completely unknown actuator faults including generator torque and pitch actuator torque. The Lyapunov direct method is employed to prove that the closed-loop system is uniformly bounded. Simulation studies are performed to verify the effectiveness of the proposed method.

Effect of Swirl on an Unstable Single-Element Gas-Gas Rocket Engine

DTIC Science & Technology

2014-06-01

at 300 K, and the combustor is filled with a mixture of water and carbon dioxide at 1500 K. The warmer temperature in the combustor enables the auto...a variety of configurations including gas turbines and rocket engines.4–13 The single-element engine chosen for this study is the continuously...combustion systems including gas turbines , rocket engines, and industrial furnaces. Swirl can have dramatic effects on the flowfield; these include jet growth

Effects and mechanisms of kerosene use-related toxicity.

PubMed

Maiyoh, Geoffrey K; Njoroge, Rachel W; Tuei, Vivian C

2015-07-01

Kerosene is a heterogeneous hydrocarbon substance that continues to find many uses worldwide due to its economic viability and ease of availability. In spite of kerosene's many uses, it is known to cause harm to various body organs and systems. Major affected body organs/systems are the pulmonary system, central nervous system, cardiovascular system, the skin, immune system and liver. This review discusses the various kerosene-mediated adverse health effects and possible mechanisms by which kerosene is likely to inflict such effects. These mechanisms are quite varied and include induction of inflammation, loss of effectiveness of pulmonary surfactants, hypoxia, production of highly reactive oxidative metabolites, extraction of endogenous epidermal and membrane lipids, necrosis, hormonal and enzymatic levels changes, and immunosuppression. Understanding of the above will allow for proper relevant policy formulation and targeted kerosene-mediated morbidity and mortality preventive and management initiatives. Copyright © 2015 Elsevier B.V. All rights reserved.

Strategies and Systems-Level Interventions to Combat or Prevent Drug Counterfeiting: A Systematic Review of Evidence Beyond Effectiveness.

PubMed

Fadlallah, Racha; El-Jardali, Fadi; Annan, Farah; Azzam, Hayat; Akl, Elie A

2016-01-01

A recent systematic review suggested that drug registrations and onsite quality inspections may be effective in reducing the prevalence of counterfeit and substandard drugs. However, simply replicating the most effective interventions is problematic, as it denotes implementing the intervention without further adaptation. The aim was to systematically review the evidence beyond effectiveness for systems-level interventions to combat or prevent drug counterfeiting. We conducted an extensive search, including an electronic search of 14 databases. We included studies examining the efficiency, feasibility, reliability, and economic outcomes of the interventions, as well as barriers and facilitators to their implementation. Two reviewers selected eligible studies and abstracted data in duplicate and independently. We synthesized the results narratively, stratified by type of intervention. Of 10,220 captured citations, 19 met our inclusion criteria. The findings suggest that the following may strengthen regulatory measures (e.g., registration): minimizing drug diversion, enhancing lines of communications, ensuring feedback on drug quality, and promoting strict licensing criteria. There is evidence that onsite quality surveillance and inspection systems may be efficient and cost-effective for preliminary testing of large samples of drugs. Laws and legislation need to be specific to counterfeit drugs, include firm penalties, address online purchasing of drugs, and be complemented by education of judges and lawyers. Public awareness and education should rely on multiple platforms and comprehensive and dedicated content. While product authentication technologies may be efficient and reliable in detecting counterfeit drugs in the supply chain, they require a strong information system infrastructure. As for pharmacovigilance systems, it is critical to tackle the issue of underreporting, to enhance their chances of success. Several factors are critical to the successful design and implementation of systems-level interventions to combat or prevent drug counterfeiting. Policymakers need to take these into consideration to ensure success of these interventions.

VETA x ray data acquisition and control system

NASA Technical Reports Server (NTRS)

Brissenden, Roger J. V.; Jones, Mark T.; Ljungberg, Malin; Nguyen, Dan T.; Roll, John B., Jr.

1992-01-01

We describe the X-ray Data Acquisition and Control System (XDACS) used together with the X-ray Detection System (XDS) to characterize the X-ray image during testing of the AXAF P1/H1 mirror pair at the MSFC X-ray Calibration Facility. A variety of X-ray data were acquired, analyzed and archived during the testing including: mirror alignment, encircled energy, effective area, point spread function, system housekeeping and proportional counter window uniformity data. The system architecture is presented with emphasis placed on key features that include a layered UNIX tool approach, dedicated subsystem controllers, real-time X-window displays, flexibility in combining tools, network connectivity and system extensibility. The VETA test data archive is also described.

USSR Space Life Sciences Digest, issue 1

NASA Technical Reports Server (NTRS)

Hooke, L. R.; Radtke, M.; Rowe, J. E.

1985-01-01

The first issue of the bimonthly digest of USSR Space Life Sciences is presented. Abstracts are included for 49 Soviet periodical articles in 19 areas of aerospace medicine and space biology, published in Russian during the first quarter of 1985. Translated introductions and table of contents for nine Russian books on topics related to NASA's life science concerns are presented. Areas covered include: botany, cardiovascular and respiratory systems, cybernetics and biomedical data processing, endocrinology, gastrointestinal system, genetics, group dynamics, habitability and environmental effects, health and medicine, hematology, immunology, life support systems, man machine systems, metabolism, musculoskeletal system, neurophysiology, perception, personnel selection, psychology, radiobiology, reproductive system, and space biology. This issue concentrates on aerospace medicine and space biology.

Facilitating Children's Ability to Distinguish Symbols for Emotions: The Effects of Background Color Cues and Spatial Arrangement of Symbols on Accuracy and Speed of Search

ERIC Educational Resources Information Center

Wilkinson, Krista M.; Snell, Julie

2011-01-01

Purpose: Communication about feelings is a core element of human interaction. Aided augmentative and alternative communication systems must therefore include symbols representing these concepts. The symbols must be readily distinguishable in order for users to communicate effectively. However, emotions are represented within most systems by…

Changing the System of Student Support in Norway: Intended and Unintended Effects on Students

ERIC Educational Resources Information Center

Opheim, V.

2011-01-01

In 2002 the student finance system in Norway went through a major restructuring. The changes included an increase in student support and an introduction of progression-dependent grants. Using two student welfare surveys conducted in 1998 and 2005, the paper analyses the effect of the changes on the students. The analysis compares the risk of study…

The Effectiveness of Combining Tangible Symbols with the Picture Exchange Communication System to Teach Requesting Skills to Children with Multiple Disabilities Including Visual Impairment

ERIC Educational Resources Information Center

Ali, Emad

2009-01-01

The Picture Exchange Communication System (PECS) is an augmentative and alternative communication program (Frost & Bondy, 2002). Although PECS has been effectively used to teach functional requesting skills for children with autism, mental retardation, visual impairment, and physical disabilities (e.g., Anderson, Moore, & Bourne, 2007; Chambers &…

The Effects of Various Mounting Systems of near Magnification on Reading Performance and Preference in School-Age Students with Low Vision

ERIC Educational Resources Information Center

Lusk, Kelly E.

2012-01-01

This single-subject study explored the effects of different mounting systems of prescribed near magnification (handheld, stand-mounted, spectacle-mounted, and electronic) on reading performance and preference in students with low vision. Participants included five students ranging from 3rd to 11th grade, and with various etiologies. Reading…

Effectiveness of direct-acting antiviral therapy for hepatitis C in difficult-to-treat patients in a safety-net health system: a retrospective cohort study.

PubMed

Yek, Christina; de la Flor, Carolina; Marshall, John; Zoellner, Cindy; Thompson, Grace; Quirk, Lisa; Mayorga, Christian; Turner, Barbara J; Singal, Amit G; Jain, Mamta K

2017-11-20

Direct-acting antivirals (DAAs) have revolutionized chronic hepatitis C (HCV) treatment, but real-world effectiveness among vulnerable populations, including uninsured patients, is lacking. This study was conducted to characterize the effectiveness of DAAs in a socioeconomically disadvantaged and underinsured patient cohort. This retrospective observational study included all patients undergoing HCV treatment with DAA-based therapy between April 2014 and June 2016 at a large urban safety-net health system (Parkland Health and Hospital System, Dallas, TX, USA). The primary outcome was sustained virologic response (SVR), with secondary outcomes including treatment discontinuation, treatment relapse, and loss to follow-up. DAA-based therapy was initiated in 512 patients. The cohort was socioeconomically disadvantaged (56% uninsured and 13% Medicaid), with high historic rates of alcohol (41%) and substance (50%) use, and mental health disorders (38%). SVR was achieved in 90% of patients (n = 459); 26 patients (5%) were lost to follow-up. SVR was significantly lower in patients with decompensated cirrhosis (82% SVR; OR 0.37, 95% CI 0.16-0.85) but did not differ by insurance status (P = 0.98) or alcohol/substance use (P = 0.34). Reasons for treatment failure included loss to follow-up (n = 26, 5%), viral relapse (n = 16, 3%), non-treatment-related death (n = 7, 1%), and treatment discontinuation (n = 4, 1%). Of patients with viral relapse, 6 reported non-compliance and have not been retreated, 5 have been retreated and achieved SVR, 4 have undergone resistance testing but not yet initiated retreatment, and 1 was lost to follow-up. Effective outcomes with DAA-based therapy can be achieved in difficult-to-treat underinsured populations followed in resource-constrained safety-net health systems.

Radio-wave propagation for space communications systems

NASA Technical Reports Server (NTRS)

Ippolito, L. J.

1981-01-01

The most recent information on the effects of Earth's atmosphere on space communications systems is reviewed. The design and reliable operation of satellite systems that provide the many applications in space which rely on the transmission of radio waves for communications and scientific purposes are dependent on the propagation characteristics of the transmission path. The presence of atmospheric gases, clouds, fog, precipitation, and turbulence causes uncontrolled variations in the signal characteristics. These variations can result in a reduction of the quality and reliability of the transmitted information. Models and other techniques are used in the prediction of atmospheric effects as influenced by frequency, geography, elevation angle, and type of transmission. Recent data on performance characteristics obtained from direct measurements on satellite links operating to above 30 GHz have been reviewed. Particular emphasis has been placed on the effects of precipitation on the Earth/space path, including rain attenuation, and ice particle depolarization. Other factors are sky noise, antenna gain degradation, scintillations, and bandwidth coherence. Each of the various propagation factors has an effect on design criteria for communications systems. These criteria include link reliability, power margins, noise contribution, modulation and polarization factors, channel cross talk, error rate, and bandwidth limitations.

It takes a village: Exploring the impact of social determinants on delivery system outcomes for heart failure patients.

PubMed

Knighton, Andrew J; Savitz, Lucy A; Benuzillo, Jose; VanDerslice, James A

2017-06-24

Local social determinants may act as effect modifiers for the impact of neighborhood material deprivation on patient-level healthcare outcomes. The objective of this study was to understand the mediating effect of local social determinants on neighborhood material deprivation and delivery outcomes in heart failure (HF) patients. A retrospective cohort study was conducted using 4737 HF patients receiving inpatient care (n=6065 encounters) from an integrated healthcare delivery system from 2010 to 2014. Outcomes included post-discharge mortality, readmission risk and length of stay. Deprivation was measured using an area deprivation index by address of residence. Effect modifications measured included urban-rural residency and faith identification using generalized linear regression models. Patient-level data was drawn from the delivery system data warehouse. Faith identification had a significant protective effect on HF patients from deprived areas, lowering 30-day mortality odds by one-third over patients who did not identify with a faith (OR 0.35 95%CI:0.12-0.98;p=0.05). Significant effects persisted at the 90 and 180-day timeframes. In rural areas, lack of faith identification had a multiplicative effect on 30-day mortality for deprived patients (OR 14.0 95%CI:1.47-132.7;p=0.02). No significant effects were noted for other healthcare outcomes. The lack of expected association between area deprivation and healthcare outcomes in some communities may be explained by the presence of effect modifiers. Understanding existing effect modifiers for area deprivation in local communities that delivery systems serve can inform targeted quality improvement. These factors should also be considered when comparing delivery system performance for reimbursement and in population health management. Copyright © 2017 Elsevier Inc. All rights reserved.

Automated personnel data base system specifications, Task V. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartley, H.J.; Bocast, A.K.; Deppner, F.O.

1978-11-01

The full title of this study is 'Development of Qualification Requirements, Training Programs, Career Plans, and Methodologies for Effective Management and Training of Inspection and Enforcement Personnel.' Task V required the development of an automated personnel data base system for NRC/IE. This system is identified as the NRC/IE Personnel, Assignment, Qualifications, and Training System (PAQTS). This Task V report provides the documentation for PAQTS including the Functional Requirements Document (FRD), the Data Requirements Document (DRD), the Hardware and Software Capabilities Assessment, and the Detailed Implementation Schedule. Specific recommendations to facilitate implementation of PAQTS are also included.

Radiation-Related Treatment Effects across the Age Spectrum: Differences and Similarities or What The Old and Young Can Learn From Each Other

PubMed Central

Krasin, Matthew J.; Constine, Louis S.; Friedman, Debra; Marks, Lawrence B.

2010-01-01

Radiation related effects in children and adults limit the delivery of effective radiation doses and result in long-term morbidity affecting function and quality of life. Improvements in our understanding of the etiology and biology of these effects, including the influence of clinical variables, dosimetric factors, and the underlying biologic processes has made treatment safer and more efficacious. However, the approach to studying and understanding these effects differs between children and adults. By using the pulmonary and skeletal organ systems as examples, comparisons are made across the age spectrum for radiation related effects including pneumonitis, pulmonary fibrosis, osteonecrosis and fracture. Methods for dosimetric analysis, incorporation of imaging and biology as well a length of follow-up are compared, contrasted and discussed for both organ systems in children and adults. Better understanding of each age specific approach and how it differs may improve our ability to study late effects of radiation across the ages PMID:19959028

Application of the marine Ex-Bz transient system for delineating near shore resistive targets

NASA Astrophysics Data System (ADS)

Levi, Eldad; Goldman, Mark

2017-09-01

Under certain conditions, multidimensional coastal effect significantly enhances relative target response of the broadside transient marine Ex-Bz system. The effect is caused by a redistribution of the induced currents between the resistive target and the sea bottom compared to that existing in a 1-D geometry. As a result, the effect strongly depends on specific geoelectric conditions in the near-shore environment. The first study of the effect in the Mediterranean coast of central Israel was addressing shallow groundwater problem under specific geoelectric, hydrogeological and geomorphological conditions. Under different conditions (e.g. deep targets and sharp near-shore bathymetry), the influence of the effect on target response might be significantly different. More general analysis carried out in this study comprises various geoelectric scenarios that include both shallow and deep resistive targets at different distances from the shore line as well as various geometries of the target and the near-shore bathymetry. The study includes three major exploration aspects of the system, namely signal detectability, lateral and vertical resolution. Taking into account poor lateral resolution of the classical frequency domain CSEM and the limited application in shallow sea, the described broadside transient Ex-Bz system might represent a desired alternative for delineating shallow and deep resistive targets in transition zone.

Predicting the payload capability of cable logging systems including the effect of partial suspension

Treesearch

Gary D. Falk

1981-01-01

A systematic procedure for predicting the payload capability of running, live, and standing skylines is presented. Three hand-held calculator programs are used to predict payload capability that includes the effect of partial suspension. The programs allow for predictions for downhill yarding and for yarding away from the yarder. The equations and basic principles...

The toxicity of vanadium on gastrointestinal, urinary and reproductive system, and its influence on fertility and fetuses malformations.

PubMed

Wilk, Aleksandra; Szypulska-Koziarska, Dagmara; Wiszniewska, Barbara

2017-09-25

Vanadium is a transition metal that has a unique and beneficial effect on both humans and animals. For many years, studies have suggested that vanadium is an essential trace element. Its biological properties are of interest due to its therapeutic potential, including in the treatment of diabetes mellitus. Vanadium deficiencies can lead to a range of pathologies. However, excessive concentration of this metal can cause irreversible damage to various tissues and organs. Vanadium toxicity mainly manifests in gastrointestinal symptoms, including diarrhea, vomiting, and weight reduction. Vanadium also exhibits hepatotoxic and nephrotoxic properties, including glomerulonephritis and pyelonephritis. Vanadium compounds may also lead to partial degeneration of the seminiferous epithelium of the seminiferous tubules in the testes and can affect male fertility. This paper describes the harmful effects of vanadium on the morphology and physiology of both animal and human tissues, including the digestive system, the urinary tract, and the reproductive system. What is more, the following study includes data concerning the correlation between the above-mentioned metal and its influence on fertility and fetus malformations. Additionally, this research identifies the doses of vanadium which lead to pathological alterations becoming visible within tissues. Moreover, this study includes information about the protective efficacy of some substances in view of the toxicity of vanadium.

Effect of component design in retrieved bipolar hip hemiarthroplasty systems.

PubMed

Hess, Matthew D; Baker, Erin A; Salisbury, Meagan R; Kaplan, Lige M; Greene, Ryan T; Greene, Perry W

2013-09-01

Primary articulation of bipolar hemiarthroplasty systems is at the femoral head-liner interface. The purpose of this study was to compare observed damage modes on 36 retrieved bipolar systems with implant, demographic, intraoperative, and radiographic data to elucidate the effects of component design, specifically locking mechanism, on clinical performance. Retrieved bipolar hip hemiarthroplasty systems of 3 different design types were obtained, disassembled, and evaluated macro- and microscopically for varying modes of wear, including abrasion, burnishing, embedding, scratching, and pitting. Clinical record review and radiographic analysis were performed by a senior orthopedic surgery resident. Average bipolar hip hemiarthroplasty system term of service was 46 months (range, 0.27-187 months). All devices contained wear debris captured within the articulating space between the femoral head and liner. In 31% of patients without infection, lucency was observed on immediate prerevision radiographs. The system with a leaf locking mechanism showed significantly increased radiographically observed osteolysis (P=.03) compared with a system with a stopper ring locking mechanism. In addition, implant design and observed damage modes, including pitting and third-body particle embedding, were significantly associated with radiographically observed osteolysis. Copyright 2013, SLACK Incorporated.

Spacecraft VHF Radio Propagation Analysis in Ocean Environments Including Atmospheric Effects

NASA Technical Reports Server (NTRS)

Hwu, Shian; Moreno, Gerardo; Desilva, Kanishka; Jih, CIndy

2010-01-01

The Communication Systems Simulation Laboratory (CSSL) at the National Aeronautics and Space Administration (NASA)/Johnson Space Center (JSC) is tasked to perform spacecraft and ground network communication system simulations. The CSSL has developed simulation tools that model spacecraft communication systems and the space/ground environment in which they operate. This paper is to analyze a spacecraft's very high frequency (VHF) radio signal propagation and the impact to performance when landing in an ocean. Very little research work has been done for VHF radio systems in a maritime environment. Rigorous Radio Frequency (RF) modeling/simulation techniques were employed for various environmental effects. The simulation results illustrate the significance of the environmental effects on the VHF radio system performance.

Bronchoesophageal and related systems in space flight

NASA Technical Reports Server (NTRS)

Thornton, William

1991-01-01

A review is presented of the detrimental effects of space flight on the human bronchoesophageal system emphasizing related areas such as the gastric system. In-flight symptoms are listed including congestion, nasopharyngeal irritation, epigastric sensations, anorexia, and nausea. Particular attention is given to space-related effects on eating/drinking associated with the absence of hydrostatic pressure in the vascular system. The atmospheric characteristics of a typical space shuttle flight are given, and the reduced pressure and low humidity are related to bronchial, eye, and nose irritation. Earth and space versions of motion sickness are compared, and some critical differences are identified. It is proposed that more research is required to assess the effects of long-duration space travel on these related systems.

The effectiveness of water-treatment systems for arsenic used in 11 homes in Southwestern and Central Ohio, 2013

USGS Publications Warehouse

Thomas, Mary Ann; Ekberg, Mike

2016-02-23

In 2013, the U.S. Geological Survey and the Miami Conservancy District investigated the effectiveness of methods used to remove arsenic from drinking water at 11 homes in southwestern and central Ohio. The untreated (raw) ground-water had arsenic concentrations of 7.7–382 micrograms per liter (µg/L), and the median concentration was 30 µg/L. The pH was neutral to slightly alkaline, and redox conditions were strongly reducing, as indicated by high concentrations of iron. The predominant arsenic species was arsenite (As3+), which is difficult to treat because it exists in water as an uncharged compound (H3AsO3).The water-treatment systems included (1) seven single-tap reverse-osmosis systems, (2) two whole-house oxidation/filtration systems, and (3) two systems that included wholehouse anion exchange and single-tap reverse osmosis. All but one system included pretreatment by a water softener, and two systems included preoxidation to convert arsenite (As3+) to arsenate (As5+) before treatment by anion exchange.None of the treatment systems removed all of the arsenic from the drinking water. About one-half of the systems decreased the arsenic concentration to less than the maximum contamination level of 10 µg/L. The effectiveness of the systems varied widely; the percentage of arsenic removed ranged from 2 to 90 percent, and the median was 65 percent.At some sites, the low effectiveness of arsenic removal may have been related to system maintenance and(or) operation issues. At two sites, homeowners acknowledged that the treatment systems had not been maintained for several years. At two other sites, the treatment systems were being maintained, but the water-quality data indicated that one of the components was not working, unbeknownst to the homeowner. EPA research at a small number of sites in Ohio indicated that operation and maintenance of some arsenic-treatment systems was not always simple.Another factor that affected system effectiveness was the quality of the raw water. In general, the treatment systems were less effective at treating higher concentrations of arsenic. For five sites with raw-water arsenic concentrations of 10–30 µg/L, the systems removed 65–81 percent of the arsenic, and the final concentrations were less than the maximum contamination level. For three sites with higher raw-water arsenic concentrations (50–75 µg/L), the systems removed 22–34 percent of the arsenic; and the final concentrations were 4–5 times more than the maximum contamination level. Other characteristics of the raw water may have affected the performance of treatment systems; in general, raw water with the higher arsenic concentrations also had higher pH, higher concentrations of organic carbon and ammonia, and more reducing (methanogenic) redox conditions.For sites with raw-water arsenic concentrations of 10–30 µg/L, two types of systems (reverse osmosis and oxidation/filtration) removed similar amounts of arsenic, but the quality of the treated water differed in other respects. Reverse osmosis caused substantial decreases in pH, alkalinity, and concentrations of most ions. On the other hand, oxidation/filtration using manganese-based media caused a large increase of manganese concentrations, from less than 50 µg/L in raw water to more than 700 µg/L in outflow from the oxidation filtration units.It is not known if the results of this study are widely applicable; the number of systems sampled was relatively small, and each system was sampled only once. Further study may be warranted to investigate whether available methods of arsenic removal are effective/practical for residential use in areas like Ohio, were groundwater with elevated arsenic concentrations is strongly reducing, and the predominant arsenic species is arsenite (As3+).

Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

PubMed Central

German-Ponciano, León Jesús; Rosas-Sánchez, Gilberto Uriel; Rivadeneyra-Domínguez, Eduardo

2018-01-01

Flavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects, particularly as antioxidant agents. Diverse flavonoids have been studied to explore their potential therapeutic effects in the treatment of disorders of the central nervous system, including anxiety and depression. The present review discusses advances in the study of some flavonoids as potential antidepressant agents. We describe their behavioral, physiological, and neurochemical effects and the apparent mechanism of action of their preclinical antidepressant-like effects. Natural flavonoids produce antidepressant-like effects in validated behavioral models of depression. The mechanism of action of these effects includes the activation of serotonergic, dopaminergic, noradrenergic, and γ-aminobutyric acid-ergic neurotransmitter systems and an increase in the production of neural factors, including brain-derived neurotrophic factor and nerve growth factor. Additionally, alterations in the function of tropomyosin receptor kinase B and activity of the enzyme monoamine oxidase A have been reported. In conclusion, preclinical research supports the potential antidepressant effects of some natural flavonoids, which opens new possibilities of evaluating these substances to develop complementary therapeutic alternatives that could ameliorate symptoms of depressive disorders in humans. PMID:29623232

40 CFR 35.925-13 - Sewage collection system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... design capacity equivalent to that of the existing system plus a reasonable amount for future growth. For purposes of this section, a community would include any area with substantial human habitation on October... October 18, 1972; (b) The collection system is cost-effective; (c) The population density of the area to...

40 CFR 35.925-13 - Sewage collection system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... design capacity equivalent to that of the existing system plus a reasonable amount for future growth. For purposes of this section, a community would include any area with substantial human habitation on October... October 18, 1972; (b) The collection system is cost-effective; (c) The population density of the area to...

MIXING IN DISTRIBUTION SYSTEM STORAGE TANKS: ITS EFFECT ON WATER QUALITY

EPA Science Inventory

Nearly all distribution systems in the US include storage tanks and reservoirs. They are the most visible components of a wate distribution system but are generally the least understood in terms of their impact on water quality. Long residence times in storage tanks can have nega...

NASA lithium cell applications

NASA Technical Reports Server (NTRS)

Juvinall, G. L.

1978-01-01

The advantages of lithium systems are described and a general summary of their application in present and future NASA programs is presented. Benefits of the lithium systems include an increased payload weight and an increased cost effectiveness to the customer. This also allows for more flexibility in the design of future space transportation systems.

75 FR 77853 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-14

... action will be effective without further notice on January 13, 2011 unless comments are received which...: * * * * * Categories of records in the system: Delete entry and replace with ``Name, Social Security Number (SSN... school. Categories of records in the system: Name, Social Security Number (SSN), course data to include...

Saint Lawrence Seaway Navigation-Aid System Study : Volume II - Appendix B - User's Manual and Documentation of Seaway Capacity and Capacity Analysis Programs

DOT National Transportation Integrated Search

1978-09-01

The requirements for a navigation guidance system which will effect an increase in the ship processing capacity of the Saint Lawrence Seaway (Lake Ontario to Montreal, Quebec) are developed. The requirements include a specification of system position...

Effects of Aging on the Respiratory System.

ERIC Educational Resources Information Center

Levitzky, Michael G.

1984-01-01

Relates alterations in respiratory system functions occurring with aging to changes in respiratory system structure during the course of life. Main alterations noted include loss of alveolar elastic recoil, alteration in chest wall structure and decreased respiratory muscle strength, and loss of surface area and changes in pulmonary circulation.…

Saint Lawrence Seaway Navigation-Aid System Study : Volume III - Appendix C - User's Manual and Documentation of the Ship Maneuvering Requirements Computer Program

DOT National Transportation Integrated Search

1978-09-01

The requirements for a navigation guidance system which will effect an increase in the ship processing capacity of the Saint Lawrence Seaway (Lake Ontario to Montreal, Quebec) are developed. The requirements include a specification of system position...

Logistics hardware and services control system

NASA Technical Reports Server (NTRS)

Koromilas, A.; Miller, K.; Lamb, T.

1973-01-01

Software system permits onsite direct control of logistics operations, which include spare parts, initial installation, tool control, and repairable parts status and control, through all facets of operations. System integrates logistics actions and controls receipts, issues, loans, repairs, fabrications, and modifications and assets in predicting and allocating logistics parts and services effectively.

75 FR 34192 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... erroneous trades occurring from disruptions and/or malfunctions of Exchange systems. The changes described... disruptions and malfunctions. Specifically, the Exchange proposes to include ``verifiable systems disruptions... modification of transactions that resulted from verifiable disruptions and/or malfunctions of Exchanges systems...

Understanding the Civil Justice System.

ERIC Educational Resources Information Center

Hirshon, Robert E.; Bolduan, Linda M.

1997-01-01

Provides a concise and informative overview of the civil justice system. Examines various components and issues including the federal and state court systems, differences between civil and criminal law, background in common law, types of civil law, civil procedure, and the effect and implementation of civil law in everyday life. (MJP)

76 FR 72645 - Calculation of Maximum Obligation Limitation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

... United States and the use of OLA would avoid or mitigate such adverse effects. Under the systemic risk... the designated Federal agencies to the Secretary to make a systemic risk determination must include a... similar to the way that systemic risk determinations are made under section 13 of the Federal Deposit...

Evaluation of video detection systems, volume 4 : effects of adverse weather conditions in the performance of video detection systems.

DOT National Transportation Integrated Search

2009-03-01

The performance of three video detection systems (VDS): Iteris, Autoscope, and Peek, was evaluated : using a side-by-side installation at a signalized intersection under various adverse weather conditions including : rain and snow in both day and nig...

Remote vacuum or pressure sealing device and method for critical isolated systems

DOEpatents

Brock, James David [Newport News, VA; Keith, Christopher D [Newport News, VA

2012-07-10

A remote vacuum or pressure sealing apparatus and method for making a radiation tolerant, remotely prepared seal that maintains a vacuum or pressure tight seal throughout a wide temperature range. The remote sealing apparatus includes a fixed threaded sealing surface on an isolated system, a gasket, and an insert consisting of a plug with a protruding sample holder. An insert coupling device, provided for inserting samples within the isolated system, includes a threaded fastener for cooperating with the fixed threaded sealing surface on the isolated system. The insert coupling device includes a locating pin for azimuthal orientation, coupling pins, a tooted coaxial socket wrench, and an insert coupling actuator for actuating the coupling pins. The remote aspect of the sealing apparatus maintains the isolation of the system from the user's environment, safely preserving the user and the system from detrimental effect from each respectively.

Plenary.

ERIC Educational Resources Information Center

Oettinger, Anthony G.

2000-01-01

Describes the Harvard Program on Information Resources Policy (PIRP) that studies how public policy and strategic corporate decisions affect information systems, including computer technologies; postal and mechanical transportation systems; information use by civilian and military organizations; effect of new technologies; international politics;…

Interaction of feel system and flight control system dynamics on lateral flying qualities

NASA Technical Reports Server (NTRS)

Bailey, R. E.; Knotts, L. H.

1990-01-01

An experimental investigation of the influence of lateral feel system characteristics on fighter aircraft roll flying qualities was conducted using the variable stability USAF NT-33. Forty-two evaluation flights were flown by three engineering test pilots. The investigation utilized the power approach, visual landing task and up-and-away tasks including formation, gun tracking, and computer-generated compensatory attitude tracking tasks displayed on the Head-Up Display. Experimental variations included the feel system frequency, force-deflection gradient, control system command type (force or position input command), aircraft roll mode time constant, control system prefilter frequency, and control system time delay. The primary data were task performance records and evaluation pilot comments and ratings using the Cooper-Harper scale. The data highlight the unique and powerful effect of the feel system of flying qualities. The data show that the feel system is not 'equivalent' in flying qualities influence to analogous control system elements. A lower limit of allowable feel system frequency appears warranted to ensure good lateral flying qualities. Flying qualities criteria should most properly treat the feel system dynamic influence separately from the control system, since the input and output of this dynamic element is apparent to the pilot and thus, does not produce a 'hidden' effect.

Cosmological simulations of dwarf galaxies with cosmic ray feedback

NASA Astrophysics Data System (ADS)

Chen, Jingjing; Bryan, Greg L.; Salem, Munier

2016-08-01

We perform zoom-in cosmological simulations of a suite of dwarf galaxies, examining the impact of cosmic rays (CRs) generated by supernovae, including the effect of diffusion. We first look at the effect of varying the uncertain CR parameters by repeatedly simulating a single galaxy. Then we fix the comic ray model and simulate five dwarf systems with virial masses range from 8 to 30 × 1010 M⊙. We find that including CR feedback (with diffusion) consistently leads to disc-dominated systems with relatively flat rotation curves and constant star formation rates. In contrast, our purely thermal feedback case results in a hot stellar system and bursty star formation. The CR simulations very well match the observed baryonic Tully-Fisher relation, but have a lower gas fraction than in real systems. We also find that the dark matter cores of the CR feedback galaxies are cuspy, while the purely thermal feedback case results in a substantial core.

The effect of organic farming systems on species diversity

NASA Astrophysics Data System (ADS)

Leksono, Amin Setyo

2017-11-01

Organic farming systems have been well known to support the diversity of a wide range of taxa, including microorganisms, arable flora, invertebrates, birds, and mammals, which benefit from organic management leading to increases in abundance and/or species richness. The objective of this paper is to review the effect of organic farming on species diversity reported in several articles and compare this with the current study in Gondanglegi, Malang. A review of several studies showed that organic farming systems have been reported to increase species diversity, including that of mammals, birds, arthropods, vascular plants and arbuscular mycorrhizal fungi. The researchers about arthropod groups consisted of carabid beetles, butterflies, wasps, predators, and bees. Agricultural landscape, habitat type, farming system, landscape composition and connectivity all contribute to explaining species biodiversity and richness. Moreover, based on current and relevant studies, the results showed that the application of refugia blocks has increased arthropod diversity and composition.

Interventions for hiring, retaining and training district health systems managers in low- and middle-income countries.

PubMed

Rockers, Peter C; Bärnighausen, Till

2013-04-30

District managers are playing an increasingly important role in determining the performance of health systems in low- and middle-income countries as a result of decentralization. To assess the effectiveness of interventions to hire, retain and train district health systems managers in low- and middle-income countries. We searched a wide range of international databases, including the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE. We also searched online resources of international agencies, including the World Bank, to find relevant grey literature. Searches were conducted in December 2011. District health systems managers are those persons who are responsible for overseeing the operations of the health system within a defined, subnational geographical area that is designated as a district. Hiring and retention interventions include those that aim to increase the attractiveness of district management positions, as well as those related to hiring and retention processes, such as private contracting. Training interventions include education programs to develop future managers and on-the-job training programs for current managers. To be included, studies needed to use one of the following study designs: randomized controlled trial, nonrandomized controlled trial, controlled before-and-after study, and interrupted time series analysis. We report measures of effect in the same way that the primary study authors have reported them. Due to the varied nature of interventions included in this review we could not pool data across studies. Two studies met our inclusion criteria. The findings of one study conducted in Cambodia provide low quality evidence that private contracts with international nongovernmental organizations (NGOs) for district health systems management ('contracting-in') may improve health care access and utilization. Contracting-in increased use of antenatal care by 28% and use of public facilities by 14%. However, contracting-in was not found to have an effect on population health outcomes. The findings of the other study provide low quality evidence that intermittent training courses over 18 months may improve district health system managers' performance. In three countries in Latin America, managers who did not receive the intermittent training courses had between 2.4 and 8.3 times more management deficiencies than managers who received the training courses. No studies that aimed to investigate interventions for retaining district health systems managers met our study selection criteria for inclusion in this review. There is low quality evidence that contracting-in may improve health care accessibility and utilization and that intermittent training courses may improve district health systems managers' performance. More evidence is required before firm conclusions can be drawn regarding the effectiveness of these interventions in diverse settings. Other interventions that might be promising candidates for hiring and retaining (e.g., government regulations, professional support programs) as well as training district health systems managers (e.g., in-service workshops with on-site support) have not been adequately investigated.

What constitutes an effective community pharmacy?--development of a preliminary model of organizational effectiveness through concept mapping with multiple stakeholders.

PubMed

Scahill, S L; Harrison, J; Carswell, P

2010-08-01

To develop a multi-constituent model of organizational effectiveness for community pharmacy. Using Concept Systems software, a project with 14 stakeholders included a three stage process: (i) face to face brainstorming to generate statements describing what constitutes an effective community pharmacy, followed by (ii) statement reduction and approval by participants, followed by (iii) sorting of the statements into themes with rating of each statement for importance. Primary care in a government-funded, national health care system. A multi-constituent group representing policy-makers and health care providers including; community pharmacy, professional pharmacy organizations, primary health care funders and policy-makers, general practitioners and general practice support organizations. Statement clusters included: 'has safe and effective workflows', 'contributes to the safe use of medicines', 'manages human resources and has leadership', 'has a community focus', 'is integrated within primary care', 'is a respected innovator', 'provides health promotion and preventative care', 'communicates and advocates'. These clusters fit into a quadrant model setting stakeholder focus against role development. The poles of stakeholder focus are 'internal capacity' and 'social utility'. The poles of role development are labelled 'traditional safety roles' and 'integration and innovation'. Organizational effectiveness in community pharmacy includes the internal and external focus of the organization and role development. Our preliminary model describes an effective community pharmacy and provides a platform for investigation of the factors that may influence the organizational effectiveness of individual community pharmacies now and into the future.

Conference Abstracts: AEDS '84.

ERIC Educational Resources Information Center

Baird, William E.

1985-01-01

The Association of Educational Data Systems (AEDS) conference included 102 presentations. Abstracts of seven of these presentations are provided. Topic areas considered include LOGO, teaching probability through a computer game, writing effective computer assisted instructional materials, computer literacy, research on instructional…

A spin-recovery parachute system for light general-aviation airplanes

NASA Technical Reports Server (NTRS)

Bradshaw, C.

1980-01-01

A tail mounted spin recovery parachute system was designed and developed for use on light general aviation airplanes. The system was designed for use on typical airplane configurations, including low wing, high wing, single engine and twin engine designs. A mechanically triggered pyrotechnic slug gun is used to forcibly deploy a pilot parachute which extracts a bag that deploys a ring slot spin recovery parachute. The total system weighs 8.2 kg. System design factors included airplane wake effects on parachute deployment, prevention of premature parachute deployment, positive parachute jettison, compact size, low weight, system reliability, and pilot and ground crew safety. Extensive ground tests were conducted to qualify the system. The recovery parachute was used successfully in flight 17 times.

Prospective Relations between Family Conflict and Adolescent Maladjustment: Security in the Family System as a Mediating Process

PubMed Central

Cummings, E. Mark; Koss, Kalsea J.; Davies, Patrick T.

2018-01-01

Conflict in specific family systems (e.g., interparental, parent-child) has been implicated in the development of a host of adjustment problems in adolescence, but little is known about the impact of family conflict involving multiple family systems. Furthermore, questions remain about the effects of family conflict on symptoms of specific disorders and adjustment problems and the processes mediating these effects. The present study prospectively examines the impact of family conflict and emotional security about the family system on adolescent symptoms of specific disorders and adjustment problems, including the development of symptoms of anxiety, depression, conduct problems, and peer problems. Security in the family system was examined as a mediator of these relations. Participants included 295 mother-father-adolescent families (149 girls) participating across three annual time points (grades 7–9). Including auto-regressive controls for initial levels of emotional insecurity and multiple adjustment problems (T1), higher-order emotional insecurity about the family system (T2) mediated relations between T1 family conflict and T3 peer problems, anxiety, and depressive symptoms. Further analyses supported specific patterns of emotional security/insecurity (i.e., security, disengagement, preoccupation) as mediators between family conflict and specific domains of adolescent adjustment. Family conflict was thus found to prospectively predict the development of symptoms of multiple specific adjustment problems, including symptoms of depression, anxiety, conduct problems, and peer problems, by elevating in in adolescent’s emotional insecurity about the family system. The clinical implications of these findings are considered. PMID:25131144

Nuclear Power and the Environment.

ERIC Educational Resources Information Center

Dukert, Joseph M.

Described are the major environmental effects resulting from the production of electricity by nuclear power plants. Discussed are effects of waste heat, radioactivity, radioactive waste elimination, costs, and future prospects. Included are diagrams illustrating cooling tower operation, effects of thermal discharge into water systems, radioactive…

MOD-0A 200 kW wind turbine generator design and analysis report

NASA Astrophysics Data System (ADS)

Anderson, T. S.; Bodenschatz, C. A.; Eggers, A. G.; Hughes, P. S.; Lampe, R. F.; Lipner, M. H.; Schornhorst, J. R.

1980-08-01

The design, analysis, and initial performance of the MOD-OA 200 kW wind turbine generator at Clayton, NM is documented. The MOD-OA was designed and built to obtain operation and performance data and experience in utility environments. The project requirements, approach, system description, design requirements, design, analysis, system tests, installation, safety considerations, failure modes and effects analysis, data acquisition, and initial performance for the wind turbine are discussed. The design and analysis of the rotor, drive train, nacelle equipment, yaw drive mechanism and brake, tower, foundation, electricl system, and control systems are presented. The rotor includes the blades, hub, and pitch change mechanism. The drive train includes the low speed shaft, speed increaser, high speed shaft, and rotor brake. The electrical system includes the generator, switchgear, transformer, and utility connection. The control systems are the blade pitch, yaw, and generator control, and the safety system. Manual, automatic, and remote control are discussed. Systems analyses on dynamic loads and fatigue are presented.

MOD-0A 200 kW wind turbine generator design and analysis report

NASA Technical Reports Server (NTRS)

Anderson, T. S.; Bodenschatz, C. A.; Eggers, A. G.; Hughes, P. S.; Lampe, R. F.; Lipner, M. H.; Schornhorst, J. R.

1980-01-01

The design, analysis, and initial performance of the MOD-OA 200 kW wind turbine generator at Clayton, NM is documented. The MOD-OA was designed and built to obtain operation and performance data and experience in utility environments. The project requirements, approach, system description, design requirements, design, analysis, system tests, installation, safety considerations, failure modes and effects analysis, data acquisition, and initial performance for the wind turbine are discussed. The design and analysis of the rotor, drive train, nacelle equipment, yaw drive mechanism and brake, tower, foundation, electricl system, and control systems are presented. The rotor includes the blades, hub, and pitch change mechanism. The drive train includes the low speed shaft, speed increaser, high speed shaft, and rotor brake. The electrical system includes the generator, switchgear, transformer, and utility connection. The control systems are the blade pitch, yaw, and generator control, and the safety system. Manual, automatic, and remote control are discussed. Systems analyses on dynamic loads and fatigue are presented.

Slanted-edge MTF testing for establishing focus alignment at infinite conjugate of space optical systems with gravity sag effects

NASA Astrophysics Data System (ADS)

Newswander, T.; Riesland, David W.; Miles, Duane; Reinhart, Lennon

2017-09-01

For space optical systems that image extended scenes such as earth-viewing systems, modulation transfer function (MTF) test data is directly applicable to system optical resolution. For many missions, it is the most direct metric for establishing the best focus of the instrument. Additionally, MTF test products can be combined to predict overall imaging performance. For fixed focus instruments, finding the best focus during ground testing is critical to achieving good imaging performance. The ground testing should account for the full-imaging system, operational parameters, and operational environment. Testing the full-imaging system removes uncertainty caused by breaking configurations and the combination of multiple subassembly test results. For earth viewing, the imaging system needs to be tested at infinite conjugate. Operational environment test conditions should include temperature and vacuum. Optical MTF testing in the presence of operational vibration and gravity release is less straightforward and may not be possible on the ground. Gravity effects are mitigated by testing in multiple orientations. Many space telescope systems are designed and built to have optimum performance in a gravity-free environment. These systems can have imaging performance that is dominated by aberration including astigmatism. This paper discusses how the slanted edge MTF test is applied to determine the best focus of a space optical telescope in ground testing accounting for gravity sag effects. Actual optical system test results and conclusions are presented.

Emergency warning for people with disabilities.

PubMed

Putkovich, Kenneth

2013-01-01

The intent of this article is to assess the current state of Emergency Warning capabilities in the United States and make recommendations on what needs to be done to cost effectively establish a National Emergency Warning System to best serve the people of the United States, including those with disabilities. As part of this assessment, terminology will be defined, existing systems will be examined, critical needs and functions will be explained, and recommendations made for a system to deliver emergency messages to those people immediately at risk from natural and human-caused disasters in a timely and effective manner, regardless of location or situational circumstance. The assessment will include the needs and available technologies for delivering emergency warnings to people with disabilities, which are generally little understood, poorly addressed, and often ignored.

Design and application of squeeze film dampers for turbomachinery stabilization

NASA Technical Reports Server (NTRS)

Gunter, E. J.; Barrett, L. E.; Allaire, P. E.

1975-01-01

The steady-state transient response of the squeeze film damper bearing was investigated. Both the steady-state and transient equations for the hydrodynamic bearing forces are derived; the steady-state equations were used to determine the damper equivalent stiffness and damping coefficients. These coefficients are used to find the damper configuration which will provide the optimum support characteristics based on a stability analysis of the rotor-bearing system. The effects of end seals and cavitated fluid film are included. The transient analysis of rotor-bearing systems was conducted by coupling the damping and rotor equations and integrating forward in time. The effects of unbalance, cavitation, and retainer springs are included. Methods of determining the stability of a rotor-bearing system under the influence of aerodynamic forces and internal shaft friction are discussed.

Separation of presampling and postsampling modulation transfer functions in infrared sensor systems

NASA Astrophysics Data System (ADS)

Espinola, Richard L.; Olson, Jeffrey T.; O'Shea, Patrick D.; Hodgkin, Van A.; Jacobs, Eddie L.

2006-05-01

New methods of measuring the modulation transfer function (MTF) of electro-optical sensor systems are investigated. These methods are designed to allow the separation and extraction of presampling and postsampling components from the total system MTF. The presampling MTF includes all the effects prior to the sampling stage of the imaging process, such as optical blur and detector shape. The postsampling MTF includes all the effects after sampling, such as interpolation filters and display characteristics. Simulation and laboratory measurements are used to assess the utility of these techniques. Knowledge of these components and inclusion into sensor models, such as the U.S. Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate's NVThermIP, will allow more accurate modeling and complete characterization of sensor performance.

Planning and scheduling the Hubble Space Telescope: Practical application of advanced techniques

NASA Technical Reports Server (NTRS)

Miller, Glenn E.

1994-01-01

NASA's Hubble Space Telescope (HST) is a major astronomical facility that was launched in April, 1990. In late 1993, the first of several planned servicing missions refurbished the telescope, including corrections for a manufacturing flaw in the primary mirror. Orbiting above the distorting effects of the Earth's atmosphere, the HST provides an unrivaled combination of sensitivity, spectral coverage and angular resolution. The HST is arguably the most complex scientific observatory ever constructed and effective use of this valuable resource required novel approaches to astronomical observation and the development of advanced software systems including techniques to represent scheduling preferences and constraints, a constraint satisfaction problem (CSP) based scheduler and a rule based planning system. This paper presents a discussion of these systems and the lessons learned from operational experience.

Development of the workflow kine systems for support on KAIZEN.

PubMed

Mizuno, Yuki; Ito, Toshihiko; Yoshikawa, Toru; Yomogida, Satoshi; Morio, Koji; Sakai, Kazuhiro

2012-01-01

In this paper, we introduce the new workflow line system consisted of the location and image recording, which led to the acquisition of workflow information and the analysis display. From the results of workflow line investigation, we considered the anticipated effects and the problems on KAIZEN. Workflow line information included the location information and action contents information. These technologies suggest the viewpoints to help improvement, for example, exclusion of useless movement, the redesign of layout and the review of work procedure. Manufacturing factory, it was clear that there was much movement from the standard operation place and accumulation residence time. The following was shown as a result of this investigation, to be concrete, the efficient layout was suggested by this system. In the case of the hospital, similarly, it is pointed out that the workflow has the problem of layout and setup operations based on the effective movement pattern of the experts. This system could adapt to routine work, including as well as non-routine work. By the development of this system which can fit and adapt to industrial diversification, more effective "visual management" (visualization of work) is expected in the future.

RF verification tasks underway at the Harris Corporation for multiple aperture reflector system

NASA Technical Reports Server (NTRS)

Gutwein, T. A.

1982-01-01

Mesh effects on gain and patterns and adjacent aperture coupling effects for "pie" and circular apertures are discussed. Wire effects for Harris model with Langley scale model results included for assessing D/lamda effects, and wire effects with adjacent aperture coupling were determined. Reflector surface distortion effects (pillows and manufacturing roughness) were studied.

Supersonic cruise research aircraft structural studies: Methods and results

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, J.; Gross, D.; Kurtze, W.; Newsom, J.; Wrenn, G.; Greene, W.

1981-01-01

NASA Langley Research Center SCAR in-house structural studies are reviewed. In methods development, advances include a new system of integrated computer programs called ISSYS, progress in determining aerodynamic loads and aerodynamically induced structural loads (including those due to gusts), flutter optimization for composite and metal airframe configurations using refined and simplified mathematical models, and synthesis of active controls. Results given address several aspects of various SCR configurations. These results include flutter penalties on composite wing, flutter suppression using active controls, roll control effectiveness, wing tip ground clearance, tail size effect on flutter, engine weight and mass distribution influence on flutter, and strength and flutter optimization of new configurations. The ISSYS system of integrated programs performed well in all the applications illustrated by the results, the diversity of which attests to ISSYS' versatility.

A multichannel EEG telemetry system utilizing a PCM subcarrier

NASA Technical Reports Server (NTRS)

Fryer, T. B.

1974-01-01

A multichannel personal-type telemetry system is described that utilizes PCM encoding for the most effective range with minimum RF bandwidth and noise interference. Recent IC developments (COS MOS) make it possible to implement a sophisticated encoding system (PCM) within the low power and size constraints necessary for a personal biotelemetry system. This system includes low-level high-impedance preamplifiers to make the system suitable for EEG recording.

Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins.

PubMed

Cai, Yuee; Zhang, Jinming; Chen, Nelson G; Shi, Zhi; Qiu, Jiange; He, Chengwei; Chen, Meiwan

2017-07-01

Tannins, polyphenols in medicinal plants, have been divided into two groups of hydrolysable and condensed tannins, including gallotannins, ellagitannins, and (-)-epigallocatechin-3-gallate (EGCG). Potent anticancer activities have been observed in tannins (especially EGCG) with multiple mechanisms, such as apoptosis, cell cycle arrest, and inhibition of invasion and metastases. Furthermore, the combinational effects of tannins and anticancer drugs have been demonstrated in this review, including chemoprotective, chemosensitive, and antagonizing effects accompanying with anticancer effect. However, the applications of tannins have been hindered due to their poor liposolubility, low bioavailability, off-taste, and shorter half-life time in human body, such as EGCG, gallic acid, and ellagic acid. To tackle these obstacles, novel drug delivery systems have been employed to deliver tannins with the aim of improving their applications, such as gelatin nanoparticles, micelles, nanogold, liposomes, and so on. In this review, the chemical characteristics, anticancer properties, and drug delivery systems of tannins were discussed with an attempt to provide a systemic reference to promote the development of tannins as anticancer agents. © 2016 Wiley Periodicals, Inc.

Cost-benefit analysis of electronic medical record system at a tertiary care hospital.

PubMed

Choi, Jong Soo; Lee, Woo Baik; Rhee, Poong-Lyul

2013-09-01

Although Electronic Medical Record (EMR) systems provide various benefits, there are both advantages and disadvantages regarding its cost-effectiveness. This study analyzed the economic effects of EMR systems using a cost-benefit analysis based on the differential costs of managerial accounting. Samsung Medical Center (SMC) is a general hospital in Korea that developed an EMR system for outpatients from 2006 to 2008. This study measured the total costs and benefits during an 8-year period after EMR adoption. The costs include the system costs of building the EMR and the costs incurred in smoothing its adoption. The benefits included cost reductions after its adoption and additional revenues from both remodeling of paper-chart storage areas and medical transcriptionists' contribution. The measured amounts were discounted by SMC's expected interest rate to calculate the net present value (NPV), benefit-cost ratio (BCR), and discounted payback period (DPP). During the analysis period, the cumulative NPV and the BCR were US$3,617 thousand and 1.23, respectively. The DPP was about 6.18 years. Although the adoption of an EMR resulted in overall growth in administrative costs, it is cost-effective since the cumulative NPV was positive. The positive NPV was attributed to both cost reductions and additional revenues. EMR adoption is not so attractive to management in that the DPP is longer than 5 years at 6.18 and the BCR is near 1 at 1.23. However, an EMR is a worthwhile investment, seeing that this study did not include any qualitative benefits and that the paper-chart system was cost-centric.

Predicting the effects of unmodeled dynamics on an aircraft flight control system design using eigenspace assignment

NASA Technical Reports Server (NTRS)

Johnson, Eric N.; Davidson, John B.; Murphy, Patrick C.

1994-01-01

When using eigenspace assignment to design an aircraft flight control system, one must first develop a model of the plant. Certain questions arise when creating this model as to which dynamics of the plant need to be included in the model and which dynamics can be left out or approximated. The answers to these questions are important because a poor choice can lead to closed-loop dynamics that are unpredicted by the design model. To alleviate this problem, a method has been developed for predicting the effect of not including certain dynamics in the design model on the final closed-loop eigenspace. This development provides insight as to which characteristics of unmodeled dynamics will ultimately affect the closed-loop rigid-body dynamics. What results from this insight is a guide for eigenstructure control law designers to aid them in determining which dynamics need or do not need to be included and a new way to include these dynamics in the flight control system design model to achieve a required accuracy in the closed-loop rigid-body dynamics. The method is illustrated for a lateral-directional flight control system design using eigenspace assignment for the NASA High Alpha Research Vehicle (HARV).

External impacts of an intraurban air transportation system in the San Francisco Bay area

NASA Technical Reports Server (NTRS)

Lu, J. Y.; Gebman, J. R.; Kirkwood, T. F.; Mcclure, P. T.; Stucker, J. P.

1972-01-01

The effects are studied of an intraurban V/STOL commuter system on the economic, social, and physical environment of the San Francisco Bay Area. The Bay Area was chosen mainly for a case study; the real intent of the analysis is to develop methods by which the effects of such a system could be evaluated for any community. Aspects of the community life affected include: income and employment, benefits and costs, noise, air pollution, and road congestion.

The Human in Space: Lesson from ISS

NASA Technical Reports Server (NTRS)

Sams, Clarence F.

2009-01-01

This viewgraph presentation reviews the lessons learned from manned space flight on the International Space Station. The contents include: 1) Overview of space flight effects on crewmembers; 2) General overview of immune system; 3) How does space flight alter immune system? 4) What factors associated with space flight inteact with crewmember immune function and impact health risks? 5) What is the current understanding of space flight effects on the immune system? and 6) Why should NASA be interested in immunology? Why is it significant?

Systematic Review of Plant-Based Homeopathic Basic Research: An Update.

PubMed

Ücker, Annekathrin; Baumgartner, Stephan; Sokol, Anezka; Huber, Roman; Doesburg, Paul; Jäger, Tim

2018-05-01

 Plant-based test systems have been described as a useful tool for investigating possible effects of homeopathic preparations. The last reviews of this research field were published in 2009/2011. Due to recent developments in the field, an update is warranted. Publications on plant-based test systems were analysed with regard to publication quality, reproducibility and potential for further research.  A literature search was conducted in online databases and specific journals, including publications from 2008 to 2017 dealing with plant-based test systems in homeopathic basic research. To be included, they had to contain statistical analysis and fulfil quality criteria according to a pre-defined manuscript information score (MIS). Publications scoring at least 5 points (maximum 10 points) were assumed to be adequate. They were analysed for the use of adequate controls, outcome and reproducibility.  Seventy-four publications on plant-based test systems were found. Thirty-nine publications were either abstracts or proceedings of conferences and were excluded. From the remaining 35 publications, 26 reached a score of 5 or higher in the MIS. Adequate controls were used in 13 of these publications. All of them described specific effects of homeopathic preparations. The publication quality still varied: a substantial number of publications (23%) did not adequately document the methods used. Four reported on replication trials. One replication trial found effects of homeopathic preparations comparable to the original study. Three replication trials failed to confirm the original study but identified possible external influencing factors. Five publications described novel plant-based test systems. Eight trials used systematic negative control experiments to document test system stability.  Regarding research design, future trials should implement adequate controls to identify specific effects of homeopathic preparations and include systematic negative control experiments. Further external and internal replication trials, and control of influencing factors, are needed to verify results. Standardised test systems should be developed. The Faculty of Homeopathy.

An architecture for automated fault diagnosis. [Space Station Module/Power Management And Distribution

NASA Technical Reports Server (NTRS)

Ashworth, Barry R.

1989-01-01

A description is given of the SSM/PMAD power system automation testbed, which was developed using a systems engineering approach. The architecture includes a knowledge-based system and has been successfully used in power system management and fault diagnosis. Architectural issues which effect overall system activities and performance are examined. The knowledge-based system is discussed along with its associated automation implications, and interfaces throughout the system are presented.

Facility Systems, Ground Support Systems, and Ground Support Equipment General Design Requirements

NASA Technical Reports Server (NTRS)

Thaxton, Eric A.; Mathews, Roger E.

2014-01-01

This standard establishes requirements and guidance for design and fabrication of ground systems (GS) that includes: ground support equipment (GSE), ground support systems (GSS), and facility ground support systems (F GSS) to provide uniform methods and processes for design and development of robust, safe, reliable, maintainable, supportable, and cost-effective GS in support of space flight and institutional programs and projects.

Mixed Methods Approach to Assessing an Informal Buddy Support System for Canadian Forces Reservists

DTIC Science & Technology

2011-04-01

implemented, perceptions regarding the effectiveness of the system, changes recommended as well as benefits and drawbacks of the system. In order to...families, and provide a better understanding of the system in general, including variations in how it is implemented, perceptions regarding the...Participant perceptions of the system Pre deployment experiences During deployment Post deployment experiences Recommendations made by

Analyzing Effect of System Inertia on Grid Frequency Forecasting Usnig Two Stage Neuro-Fuzzy System

NASA Astrophysics Data System (ADS)

Chourey, Divyansh R.; Gupta, Himanshu; Kumar, Amit; Kumar, Jitesh; Kumar, Anand; Mishra, Anup

2018-04-01

Frequency forecasting is an important aspect of power system operation. The system frequency varies with load-generation imbalance. Frequency variation depends upon various parameters including system inertia. System inertia determines the rate of fall of frequency after the disturbance in the grid. Though, inertia of the system is not considered while forecasting the frequency of power system during planning and operation. This leads to significant errors in forecasting. In this paper, the effect of inertia on frequency forecasting is analysed for a particular grid system. In this paper, a parameter equivalent to system inertia is introduced. This parameter is used to forecast the frequency of a typical power grid for any instant of time. The system gives appreciable result with reduced error.

Effects of recent energy system changes on CO2 projections for the United States.

PubMed

Lenox, Carol S; Loughlin, Daniel H

2017-09-21

Recent projections of future United States carbon dioxide (CO 2 ) emissions are considerably lower than projections made just a decade ago. A myriad of factors have contributed to lower forecasts, including reductions in end-use energy service demands, improvements in energy efficiency, and technological innovations. Policies that have encouraged these changes include renewable portfolio standards, corporate vehicle efficiency standards, smart growth initiatives, revisions to building codes, and air and climate regulations. Understanding the effects of these and other factors can be advantageous as society evaluates opportunities for achieving additional CO 2 reductions. Energy system models provide a means to develop such insights. In this analysis, the MARKet ALlocation (MARKAL) model was applied to estimate the relative effects of various energy system changes that have happened since the year 2005 on CO 2 projections for the year 2025. The results indicate that transformations in the transportation and buildings sectors have played major roles in lowering projections. Particularly influential changes include improved vehicle efficiencies, reductions in projected travel demand, reductions in miscellaneous commercial electricity loads, and higher efficiency lighting. Electric sector changes have also contributed significantly to the lowered forecasts, driven by demand reductions, renewable portfolio standards, and air quality regulations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barr, G.E.; Borns, D.J.; Fridrich, C.

A comprehensive collection of scenarios is presented that connect initiating tectonic events with radionuclide releases by logical and physically possible combinations or sequences of features, events and processes. The initiating tectonic events include both discrete faulting and distributed rock deformation developed through the repository and adjacent to it, as well as earthquake-induced ground motion and changes in tectonic stress at the site. The effects of these tectonic events include impacts on the engineered-barrier system, such as container rupture and failure of repository tunnels. These effects also include a wide range of hydrologic effects such as changes in pathways and flowmore » rates in the unsaturated and saturated zones, changes in the water-table configuration, and in the development of perched-water systems. These scenarios are intended go guide performance-assessment analyses and to assist principal investigators in how essential field, laboratory, and calculational studies are used. This suite of scenarios will help ensure that all important aspects of the system disturbance related to a tectonic scenario are captured in numerical analyses. It also provides a record of all options considered by project analysts to provide documentation required for licensing agreement. The final portion of this report discusses issues remaining to be addressed with respect to tectonic activity. 105 refs.« less

Legacy system integration using web technology

NASA Astrophysics Data System (ADS)

Kennedy, Richard L.; Seibert, James A.; Hughes, Chris J.

2000-05-01

As healthcare moves towards a completely digital, multimedia environment there is an opportunity to provide for cost- effective, highly distributed physician access to clinical information including radiology-based imaging. In order to address this opportunity a Universal Clinical Desktop (UCD) system was developed. A UCD provides a single point of entry into an integrated view of all types of clinical data available within a network of disparate healthcare information systems. In order to explore the application of a UCD in a hospital environment, a pilot study was established with the University of California Davis Medical Center using technology from Trilix Information Systems. Within this pilot environment the information systems integrated under the UCD include a radiology information system (RIS), a picture archive and communication system (PACS) and a laboratory information system (LIS).

The Effectiveness of Permanent Highway Runoff Controls: Sedimentation/Filtration Systems

DOT National Transportation Integrated Search

1998-09-01

Original Report Date: October 1997. This study evaluates the performance of sedimentation/filtration systems that are the most common control for treating highway runoff in the Edwards Aquifer recharge zone. The study includes: 1) monitoring and eval...

Safety of High Speed Guided Ground Transportation Systems : Review of Existing EMF Guidelines, Standards and Regulations

DOT National Transportation Integrated Search

1993-08-01

To assess the state of knowledge about anticipated electric and magnetic field (EMF) exposures from electrical transportation systems, including electrically powered rail and magnetically levitated (maglev), research concerning biological effects of ...

EFFECT OF BACTERIAL SULFATE REDUCTION ON IRON-CORROSION SCALES

EPA Science Inventory

Iron-sulfur geochemistry is important in many natural and engineered environments including drinking water systems. In the anaerobic environment beneath scales of corroding iron drinking water distribution system pipes, sulfate reducing bacteria (SRB) produce sulfide from natura...

Effect of subsurface drainage on the structural capacity of flexible pavement.

DOT National Transportation Integrated Search

2005-01-01

Following the recommendation of the Virginia Transportation Research Council's Pavement Research Advisory Committee, this project was initiated to determine the effectiveness of including subsurface drainage systems in pavements in Virginia. The rese...

Accumulation of Contaminants in the Distribution System.

EPA Science Inventory

Removal of arsenic from water using iron-related processes including coagulation with iron salts, iron removal with oxidation/filtration, and specific iron resins is established. These processes are effective because iron solids including minerals and chemical floc have strong ad...

Development of Extinction Imagers for the Determination of Atmospheric Optical Extinction

DTIC Science & Technology

2014-08-01

system resulting from the effects of both the optics and the camera system (including the electronics). The MSI sensor includes a fiber optic taper...small dots in Fig. 7-1 are due to the fiber optic taper in the system. The brighter region near the center is due to the lens optics. To apply the...a black target wliich was a hollow black box. Clearly it would be a major advantage if we could use "targets of opportunity" from a ship, and in

UNDERSTANDING THE EFFECTS OF ATRAZINE ON STEROIDOGENESIS IN THE HUMAN H295R AND RAT GRANULOSA CELLS

EPA Science Inventory

The effects of environmental chemicals on the catalytic activity of steroidogenic enzymes, including aromatase, have been well documented. However, specific effects of environmental chemicals on steroidogenesis and the physiological impact on local and systemic concentrations of ...

Health Implications of Marijuana Use: A Review.

ERIC Educational Resources Information Center

Petersen, Robert C.

1979-01-01

Summarizes what is known about the effects of marijuana use on health. The topics included are its chemistry and the metabolism; the effects of acute intoxication on learning, memory, intellectual performance, driving, and other skilled performances; and effects on lungs, brain, heart, and other systems. (SA)

76 FR 5789 - Teaching American History Grant Program; Office of Innovation and Improvement; Overview...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... teachers, may include observations for determining teacher effectiveness (such as systems that meet the... student achievement by improving teachers' knowledge, understanding, and appreciation of traditional...--Improving the Effectiveness and Distribution of Effective Teachers or Principals (up to three additional...

Shuttle/spacelab contamination environment and effects handbook

NASA Technical Reports Server (NTRS)

Bareiss, L. E.; Payton, R. M.; Papazian, H. A.

1986-01-01

This handbook is intended to assist users of the Spacelab/Space Transportation System by providing contamination environments and effects information that may be of value in planning, designing, manufacturing, and operating a space flight experiment. A summary of available molecular and particulate contamination data on the Space Transportation System and its facilities is presented. Contamination models, contamination effects, and protection methods information are also presented. In addition to contamination, the effects of the space environments at STS altitudes on spacecraft materials are included. Extensive references, bibliographies, and contacts are provided.

Modal Analysis Using the Singular Value Decomposition and Rational Fraction Polynomials

DTIC Science & Technology

2017-04-06

information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and...results. The programs are designed for experimental datasets with multiple drive and response points and have proven effective even for systems with... designed for experimental datasets with multiple drive and response points and have proven effective even for systems with numerous closely-spaced

Knowledge Based System Applications for Guidance and Control (Application des Systemes a Base de Connaissances au Guidage-Pilotage)

DTIC Science & Technology

1991-01-01

techniques and integration concepts. Recent advances in digital computation techniques including data base management , represent the core enabling...tactical information management and effective pilot interaction are essential. Pilot decision aiding, combat automation, sensor fusion and ol-board...tactical battle management concepts offer the opportunity for substantial mission effectiveness improvements. Although real-time tactical military

A meeting with the universe: Science discoveries from the space program

NASA Technical Reports Server (NTRS)

French, B. M. (Editor); Maran, S. P. (Editor)

1981-01-01

A general history of space exploration is presented. The solar system is discussed. The Sun-Earth relationship is considered, including magnetic fields, solar wind, the magnetosphere, and the Sun-weather relationship. The universe beyond the solar system is discussed. Topics include stellar and galactic evolution, quasars and intergalactic space. The effects of weightlessness and ionizing radiation on human beings are considered. The possibility of extraterrestrial life is discussed. Lunar and planetary exploration, solar-terrestrial physics, astrophysics, biomedical research and exobiology are reviewed. Numerons color illustrations are included.

A meeting with the universe: Science discoveries from the space program

NASA Astrophysics Data System (ADS)

French, Bevan M.; Maran, Stephen P.; Chipman, Eric G.

A general history of space exploration is presented. The solar system is discussed. The Sun-Earth relationship is considered, including magnetic fields, solar wind, the magnetosphere, and the Sun-weather relationship. The universe beyond the solar system is discussed. Topics include stellar and galactic evolution, quasars and intergalactic space. The effects of weightlessness and ionizing radiation on human beings are considered. The possibility of extraterrestrial life is discussed. Lunar and planetary exploration, solar-terrestrial physics, astrophysics, biomedical research and exobiology are reviewed. Numerous color illustrations are included.

Effects of exercise training on chronic inflammation in obesity : current evidence and potential mechanisms.

PubMed

You, Tongjian; Arsenis, Nicole C; Disanzo, Beth L; Lamonte, Michael J

2013-04-01

Chronic, systemic inflammation is an independent risk factor for several major clinical diseases. In obesity, circulating levels of inflammatory markers are elevated, possibly due to increased production of pro-inflammatory cytokines from several tissues/cells, including macrophages within adipose tissue, vascular endothelial cells and peripheral blood mononuclear cells. Recent evidence supports that adipose tissue hypoxia may be an important mechanism through which enlarged adipose tissue elicits local tissue inflammation and further contributes to systemic inflammation. Current evidence supports that exercise training, such as aerobic and resistance exercise, reduces chronic inflammation, especially in obese individuals with high levels of inflammatory biomarkers undergoing a longer-term intervention. Several studies have reported that this effect is independent of the exercise-induced weight loss. There are several mechanisms through which exercise training reduces chronic inflammation, including its effect on muscle tissue to generate muscle-derived, anti-inflammatory 'myokine', its effect on adipose tissue to improve hypoxia and reduce local adipose tissue inflammation, its effect on endothelial cells to reduce leukocyte adhesion and cytokine production systemically, and its effect on the immune system to lower the number of pro-inflammatory cells and reduce pro-inflammatory cytokine production per cell. Of these potential mechanisms, the effect of exercise training on adipose tissue oxygenation is worth further investigation, as it is very likely that exercise training stimulates adipose tissue angiogenesis and increases blood flow, thereby reducing hypoxia and the associated chronic inflammation in adipose tissue of obese individuals.

Further Development and Validation of the frog Embryo Teratogenesis Assay - Xenopus (FETAX)

DTIC Science & Technology

1991-02-28

abnormalities.39 40 The teratogenic effects of serotonin in the laboratory rat include anophthalmia , hydrocephalus, exencephaly, omphalocoele and vacuolization...kinky tail. ZnSO4 in Xenopus, should be tested in parallel with hemangioma. anophthalmia and scoliosis). Skeletal a metabolic activation system to show...teratogenic effects of 0 serotonin in the laboratory rat include anophthalmia , hydrocephalus, exencephaly, omphalocele and vacuolization of myocardial cells.41

Designing for resilience

NASA Astrophysics Data System (ADS)

Dwivedi, Anurag

2014-06-01

The motivation for this work comes from a desire to improve resilience of mission critical cyber enabled systems including those used in critical infrastructure domains such as cyber, power, water, fuel, financial, healthcare, agriculture, and manufacturing. Resilience can be defined as the ability of a system to persistently meet its performance requirements despite the occurrence of adverse events. Characterizing the resilience of a system requires a clear definition of the performance requirements of the system of interest and an ability to quantify the impact on performance by the adverse events of concern. A quantitative characterization of system resilience allows the resilience requirements to be included in the system design criteria. Resilience requirements of a system are derived from the service level agreements (SLAs), measures of effectiveness (MOEs), and measures of performance (MOPs) of the services or missions supported by the system. This paper describes a methodology for designing resilient systems. The components of the methodology include resilience characterization for threat models associated with various exposure modes, requirements mapping, subsystem ranking based on criticality, and selective implementation of mitigations to improve system resilience to a desired level.

Managing patient complaints in China: a qualitative study in Shanghai

PubMed Central

Jiang, Yishi; Ying, Xiaohua; Zhang, Qian; Tang, Sirui Rae; Kane, Sumit; Mukhopadhyay, Maitrayee; Qian, Xu

2014-01-01

Objectives To examine the handling system for patient complaints and to identify existing barriers that are associated with effective management of patient complaints in China. Setting Key stakeholders of the handling system for patient complaints at the national, Shanghai municipal and hospital levels in China. Participants 35 key informants including policymakers, hospital managers, healthcare providers, users and other stakeholders in Shanghai. Primary and secondary outcome measures Semistructured interviews were conducted to understand the process of handling patient complaints and factors affecting the process and outcomes of patient complaint management. Results The Chinese handling system for patient complaints was established in the past decade. Hospitals shoulder the most responsibility of patient complaint handling. Barriers to effective management of patient complaints included service users’ low awareness of the systems in the initial stage of the process; poor capacity and skills of healthcare providers, incompetence and powerlessness of complaint handlers and non-transparent exchange of information during the process of complaint handling; conflicts between relevant actors and regulations and unjustifiable complaints by patients during solution settlements; and weak enforcement of regulations, deficient information for managing patient complaints and unwillingness of the hospitals to effectively handle complaints in the postcomplaint stage. Conclusions Barriers to the effective management of patient complaints vary at the different stages of complaint handling and perspectives on these barriers differ between the service users and providers. Information, procedure design, human resources, system arrangement, unified legal system and regulations and factors shaping the social context all play important roles in effective patient complaint management. PMID:25146715

Mark 4A project training evaluation

NASA Technical Reports Server (NTRS)

Stephenson, S. N.

1985-01-01

A participant evaluation of a Deep Space Network (DSN) is described. The Mark IVA project is an implementation to upgrade the tracking and data acquisition systems of the dSN. Approximately six hundred DSN operations and engineering maintenance personnel were surveyed. The survey obtained a convenience sample including trained people within the population in order to learn what training had taken place and to what effect. The survey questionnaire used modifications of standard rating scales to evaluate over one hundred items in four training dimensions. The scope of the evaluation included Mark IVA vendor training, a systems familiarization training seminar, engineering training classes, a on-the-job training. Measures of central tendency were made from participant rating responses. Chi square tests of statistical significance were performed on the data. The evaluation results indicated that the effects of different Mark INA training methods could be measured according to certain ratings of technical training effectiveness, and that the Mark IVA technical training has exhibited positive effects on the abilities of DSN personnel to operate and maintain new Mark IVA equipment systems.

Pest insect olfaction in an insecticide-contaminated environment: info-disruption or hormesis effect.

PubMed

Tricoire-Leignel, Hélène; Thany, Steeve Hervé; Gadenne, Christophe; Anton, Sylvia

2012-01-01

Most animals, including pest insects, live in an "odor world" and depend strongly on chemical stimuli to get information on their biotic and abiotic environment. Although integrated pest management strategies including the use of insect growth regulators (IGRs) are increasingly developed, most insect pest treatments rely on neurotoxic chemicals. These molecules are known to disrupt synaptic transmission, affecting therefore sensory systems. The wide-spread use of neurotoxic insecticides and the growing use of IGRs result in residual accumulation of low concentrations in the environment. These insecticide residues could act as an "info-disruptor" by modifying the chemical communication system, and therefore decrease chances of reproduction in target insects. However, residues can also induce a non-expected hormesis effect by enhancing reproduction abilities. Low insecticide doses might thus induce adaptive processes in the olfactory pathway of target insects, favoring the development of resistance. The effect of sublethal doses of insecticides has mainly been studied in beneficial insects such as honeybees. We review here what is known on the effects of sublethal doses of insecticides on the olfactory system of insect pests.

Assessing the influence of health systems on Type 2 Diabetes Mellitus awareness, treatment, adherence, and control: A systematic review.

PubMed

Ong, Suan Ee; Koh, Joel Jun Kai; Toh, Sue-Anne Ee Shiow; Chia, Kee Seng; Balabanova, Dina; McKee, Martin; Perel, Pablo; Legido-Quigley, Helena

2018-01-01

Type 2 Diabetes Mellitus (T2DM) is reported to affect one in 11 adults worldwide, with over 80% of T2DM patients residing in low-to-middle-income countries. Health systems play an integral role in responding to this increasing global prevalence, and are key to ensuring effective diabetes management. We conducted a systematic review to examine the health system-level factors influencing T2DM awareness, treatment, adherence, and control. A protocol for this study was published on the PROSPERO international prospective register of systematic reviews (PROSPERO 2016: CRD42016048185). Studies included in this review reported the effects of health systems factors, interventions, policies, or programmes on T2DM control, awareness, treatment, and adherence. The following databases were searched on 22 February 2017: Medline, Embase, Global health, LILACS, Africa-Wide, IMSEAR, IMEMR, and WPRIM. There were no restrictions on date, language, or study designs. Two reviewers independently screened studies for eligibility, extracted the data, and screened for risk of bias. Thereafter, we performed a narrative synthesis. A meta-analysis was not conducted due to methodological heterogeneity across different aspects of included studies. 93 studies were included for qualitative synthesis; 7 were conducted in LMICs. Through this review, we found two key health system barriers to effective T2DM care and management: financial constraints faced by the patient and limited access to health services and medication. We also found three health system factors that facilitate effective T2DM care and management: the use of innovative care models, increased pharmacist involvement in care delivery, and education programmes led by healthcare professionals. This review points to the importance of reducing, or possibly eliminating, out-of-pocket costs for diabetes medication and self-monitoring supplies. It also points to the potential of adopting more innovative and integrated models of care, and the value of task-sharing of care with pharmacists. More studies which identify the effect of health system arrangements on various outcomes, particularly awareness, are needed.

Assessing the influence of health systems on Type 2 Diabetes Mellitus awareness, treatment, adherence, and control: A systematic review

PubMed Central

Koh, Joel Jun Kai; Toh, Sue-Anne Ee Shiow; Chia, Kee Seng; Balabanova, Dina; Perel, Pablo; Legido-Quigley, Helena

2018-01-01

Background Type 2 Diabetes Mellitus (T2DM) is reported to affect one in 11 adults worldwide, with over 80% of T2DM patients residing in low-to-middle-income countries. Health systems play an integral role in responding to this increasing global prevalence, and are key to ensuring effective diabetes management. We conducted a systematic review to examine the health system-level factors influencing T2DM awareness, treatment, adherence, and control. Methods and findings A protocol for this study was published on the PROSPERO international prospective register of systematic reviews (PROSPERO 2016: CRD42016048185). Studies included in this review reported the effects of health systems factors, interventions, policies, or programmes on T2DM control, awareness, treatment, and adherence. The following databases were searched on 22 February 2017: Medline, Embase, Global health, LILACS, Africa-Wide, IMSEAR, IMEMR, and WPRIM. There were no restrictions on date, language, or study designs. Two reviewers independently screened studies for eligibility, extracted the data, and screened for risk of bias. Thereafter, we performed a narrative synthesis. A meta-analysis was not conducted due to methodological heterogeneity across different aspects of included studies. 93 studies were included for qualitative synthesis; 7 were conducted in LMICs. Through this review, we found two key health system barriers to effective T2DM care and management: financial constraints faced by the patient and limited access to health services and medication. We also found three health system factors that facilitate effective T2DM care and management: the use of innovative care models, increased pharmacist involvement in care delivery, and education programmes led by healthcare professionals. Conclusions This review points to the importance of reducing, or possibly eliminating, out-of-pocket costs for diabetes medication and self-monitoring supplies. It also points to the potential of adopting more innovative and integrated models of care, and the value of task-sharing of care with pharmacists. More studies which identify the effect of health system arrangements on various outcomes, particularly awareness, are needed. PMID:29596495

Field Demonstration of Active Desiccant-Based Outdoor Air Preconditioning Systems, Final Report: Phase 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, J.

2001-07-09

This report summarizes an investigation of the performance of two active desiccant cooling systems that were installed as pilot systems in two locations--a college dormitory and a research laboratory--during the fall of 1999. The laboratory system was assembled in the field from commercially available Trane air-handling modules combined with a standard total energy recovery module and a customized active desiccant wheel, both produced by SEMCO. The dormitory system was a factory-built, integrated system produced by SEMCO that included both active desiccant and sensible-only recovery wheels, a direct-fired gas regeneration section, and a pre-piped Trane heat pump condensing section. Both systemsmore » were equipped with direct digital control systems, complete with full instrumentation and remote monitoring capabilities. This report includes detailed descriptions of these two systems, installation details, samples of actual performance, and estimations of the energy savings realized. These pilot sites represent a continuation of previous active desiccant product development research (Fischer, Hallstrom, and Sand 2000; Fischer 2000). Both systems performed as anticipated, were reliable, and required minimal maintenance. The dehumidification/total-energy-recovery hybrid approach was particularly effective in all respects. System performance showed remarkable improvement in latent load handling capability and operating efficiency compared with the original conventional cooling system and with the conventional system that remained in another, identical wing of the facility. The dehumidification capacity of the pilot systems was very high, the cost of operation was very low, and the system was cost-effective, offering a simple payback for these retrofit installations of approximately 5 to 6 years. Most important, the dormitory system resolved numerous indoor air quality problems in the dormitory by providing effective humidity control and increased, continuous ventilation air.« less

Uncertainty Analysis of Seebeck Coefficient and Electrical Resistivity Characterization

NASA Technical Reports Server (NTRS)

Mackey, Jon; Sehirlioglu, Alp; Dynys, Fred

2014-01-01

In order to provide a complete description of a materials thermoelectric power factor, in addition to the measured nominal value, an uncertainty interval is required. The uncertainty may contain sources of measurement error including systematic bias error and precision error of a statistical nature. The work focuses specifically on the popular ZEM-3 (Ulvac Technologies) measurement system, but the methods apply to any measurement system. The analysis accounts for sources of systematic error including sample preparation tolerance, measurement probe placement, thermocouple cold-finger effect, and measurement parameters; in addition to including uncertainty of a statistical nature. Complete uncertainty analysis of a measurement system allows for more reliable comparison of measurement data between laboratories.

The design of radiation-hardened ICs for space - A compendium of approaches

NASA Technical Reports Server (NTRS)

Kerns, Sherra E.; Shafer, B. D; Rockett, L. R., Jr.; Pridmore, J. S.; Berndt, D. F.

1988-01-01

Several technologies, including bulk and epi CMOS, CMOS/SOI-SOS (silicon-on-insulator-silicon-on-sapphire), CML (current-mode logic), ECL (emitter-coupled logic), analog bipolar (JI, single-poly DI, and SOI) and GaAs E/D (enhancement/depletion) heterojunction MESFET, are discussed. The discussion includes the direct effects of space radiation on microelectronic materials and devices, how these effects are evidenced in circuit and device design parameter variations, the particular effects of most significance to each functional class of circuit, specific techniques for hardening high-speed circuits, design examples for integrated systems, including operational amplifiers and A/D (analog/digital) converters, and the computer simulation of radiation effects on microelectronic ISs.

Hydrogasification reactor and method of operating same

DOEpatents

Hobbs, Raymond; Karner, Donald; Sun, Xiaolei; Boyle, John; Noguchi, Fuyuki

2013-09-10

The present invention provides a system and method for evaluating effects of process parameters on hydrogasification processes. The system includes a hydrogasification reactor, a pressurized feed system, a hopper system, a hydrogen gas source, and a carrier gas source. Pressurized carbonaceous material, such as coal, is fed to the reactor using the carrier gas and reacted with hydrogen to produce natural gas.

Performance and Mass Modeling Subtleties in Closed-Brayton-Cycle Space Power Systems

NASA Technical Reports Server (NTRS)

Barrett, Michael J.; Johnson, Paul K.

2005-01-01

Contents include the following: 1. Closed-Brayton-cycle (CBC) thermal energy conversion is one available option for future spacecraft and surface systems. 2. Brayton system conceptual designs for milliwatt to megawatt power converters have been developed 3. Numerous features affect overall optimized power conversion system performance: Turbomachinery efficiency. Heat exchanger effectiveness. Working-fluid composition. Cycle temperatures and pressures.

Tree Diamter Effects on Cost and Productivity of Cut-to-Length Systems

Treesearch

Matthew A. Holtzscher; Bobby L. Lanford

1997-01-01

Currently, there is a lack of economic information concerning cut-to-length harvesting systems. This study examined and measured the different costs of operating cut-to-length logging equipment over a range of average stand diameters at breast height. Three different cut-to-length logging systems were examined in this study. Systems included: 1) felier-buncher/manual/...

Nondestructive structural evaluation of wood floor systems with a vibration technique.

Treesearch

Xiping Wang; Robert J. Ross; Lawrence Andrew Soltis

2002-01-01

The objective of this study was to determine if transverse vibration methods could be used to effectively assess the structural integrity of wood floors as component systems. A total of 10 wood floor systems, including 3 laboratory-built floor sections and 7 in-place floors in historic buildings, were tested. A forced vibration method was applied to the floor systems...

Radio Wave Propagation Handbook for Communication on and Around Mars

NASA Technical Reports Server (NTRS)

Ho, Christian; Golshan, Nasser; Kliore, Arvydas

2002-01-01

This handbook examines the effects of the Martian environment on radio wave propagation on Mars and in the space near the planet. The environmental effects include these from the Martian atmosphere, ionosphere, global dust storms, aerosols, clouds, and geomorphologic features. Relevant Martian environmental parameters were extracted from the measurements of Mars missions during the past 30 years, especially from Mars Pathfinder and Mars Global Surveyor. The results derived from measurements and analyses have been reviewed through an extensive literature search. The updated parameters have been theoretically analyzed to study their effects on radio propagation. This handbook also provides basic information about the entire telecommunications environment on and around Mars for propagation researchers, system engineers, and link analysts. Based on these original analyses, some important recommendations have been made, including the use of the Martian ionosphere as a reflector for Mars global or trans-horizon communication between future Martian colonies, reducing dust storm scattering effects, etc. These results have extended our wave propagation knowledge to a planet other than Earth; and the tables, models, and graphics included in this handbook will benefit telecommunication system engineers and scientific researchers.

Observations to support adaptation: Principles, scales and decision-making

NASA Astrophysics Data System (ADS)

Pulwarty, R. S.

2012-12-01

As has been long noted, a comprehensive, coordinated observing system is the backbone of any Earth information system. Demands are increasingly placed on earth observation and prediction systems and attendant services to address the needs of economically and environmentally vulnerable sectors and investments, including energy, water, human health, transportation, agriculture, fisheries, tourism, biodiversity, and national security. Climate services include building capacity to interpret information and recognize standards and limitations of data in the promotion of social and economic development in a changing climate. This includes improving the understanding of climate in the context of a variety of temporal and spatial scales (including the influence of decadal scale forcings and land surface feedbacks on seasonal forecast reliability). Climate data and information are central for developing decision options that are sensitive to climate-related uncertainties and the design of flexible adaptation pathways. Ideally monitoring should be action oriented to support climate risk assessment and adaptation including informing robust decision making to multiple risks over the long term. Based on the experience of global observations programs and empirical research we outline- Challenges in developing effective monitoring and climate information systems to support adaptation. The types of observations of critical importance needed for sector planning to enhance food, water and energy security, and to improve early warning for disaster risk reduction Observations needed for ecosystem-based adaptation including the identification of thresholds, maintenance of biological diversity and land degradation The benefits and limits of linking regional model output to local observations including analogs and verification for adaptation planning To support these goals a robust systems of integrated observations are needed to characterize the uncertainty surrounding emergent risks including overcoming unrealistically precise information demands. While monitoring systems design and operation should be guided by the standards and requirements of management, those who provide information to the system (e.g. hydromet services) should also derive benefits. Drawing on identified information needs to support climate risk management (in drought, water resources and other areas) we outline principles of effective monitoring and develop preliminary strategic guidance for information systems being developed through the GEO, GCOS and Global and national frameworks for climate services. The efficacy of such services are improved by a problem-solving orientation, participatory planning, extension management and improvements in the use and value of existing data to legitimize new investments.

The effects of tobacco smoke and nicotine on cognition and the brain.

PubMed

Swan, Gary E; Lessov-Schlaggar, Christina N

2007-09-01

Tobacco smoke consists of thousands of compounds including nicotine. Many constituents have known toxicity to the brain, cardiovascular, and pulmonary systems. Nicotine, on the other hand, by virtue of its short-term actions on the cholinergic system, has positive effects on certain cognitive domains including working memory and executive function and may be, under certain conditions, neuroprotective. In this paper, we review recent literature, laboratory and epidemiologic, that describes the components of mainstream and sidestream tobacco smoke, including heavy metals and their toxicity, the effect of medicinal nicotine on the brain, and studies of the relationship between smoking and (1) preclinical brain changes including silent brain infarcts; white matter hyperintensities, and atrophy; (2) single measures of cognition; (3) cognitive decline over repeated measures; and (4) dementia. In most studies, exposure to smoke is associated with increased risk for negative preclinical and cognitive outcomes in younger people as well as in older adults. Potential mechanisms for smoke's harmful effects include oxidative stress, inflammation, and atherosclerotic processes. Recent evidence implicates medicinal nicotine as potentially harmful to both neurodevelopment in children and to catalyzing processes underlying neuropathology in Alzheimer's Disease. The reviewed evidence suggests caution with the use of medicinal nicotine in pregnant mothers and older adults at risk for certain neurological disease. Directions for future research in this area include the assessment of comorbidities (alcohol consumption, depression) that could confound the association between smoking and neurocognitive outcomes, the use of more specific measures of smoking behavior and cognition, the use of biomarkers to index exposure to smoke, and the assessment of cognition-related genotypes to better understand the role of interactions between smoking/nicotine and variation in genotype in determining susceptibility to the neurotoxic effects of smoking and the putative beneficial effects of medicinal nicotine.

Effectiveness of capacity building interventions relevant to public health practice: a systematic review.

PubMed

DeCorby-Watson, Kara; Mensah, Gloria; Bergeron, Kim; Abdi, Samiya; Rempel, Benjamin; Manson, Heather

2018-06-01

This systematic review assessed the effectiveness of capacity building interventions relevant to public health practice. The aim is to inform and improve capacity building interventions. Four strategies were used: 1) electronic database searching; 2) reference lists of included papers; 3) key informant consultation; and 4) grey literature searching. Inclusion (e.g., published in English) and exclusion criteria (e.g., non-English language papers published earlier than 2005) are outlined with included papers focusing on capacity building, learning plans, or professional development plans within public health and related settings, such as non-governmental organizations, government, or community-based organizations relating to public health or healthcare. Outcomes of interest included changes in knowledge, skill or confidence (self-efficacy), changes in practice (application or intent), and perceived support or supportive environments, with outcomes reported at the individual, organizational or systems level(s). Quality assessment of all included papers was completed. Fourteen papers were included in this review. These papers reported on six intervention types: 1) internet-based instruction, 2) training and workshops, 3) technical assistance, 4) education using self-directed learning, 5) communities of practice, and 6) multi-strategy interventions. The available literature showed improvements in one or more capacity-building outcomes of interest, mainly in terms of individual-level outcomes. The available literature was moderate in quality and showed a range of methodological issues. There is evidence to inform capacity building programming and how interventions can be selected to optimize impact. Organizations should carefully consider methods for analysis of capacity building interventions offered; specifically, through which mechanisms, to whom, and for which purpose. Capacity-building interventions can enhance knowledge, skill, self-efficacy (including confidence), changes in practice or policies, behaviour change, application, and system-level capacity. However in applying available evidence, organizations should consider the outcomes of highest priority, selecting intervention(s) effective for the outcome(s) of interest. Examples are given for selecting intervention(s) to match priorities and context, knowing effectiveness evidence is only one consideration in decision making. Future evaluations should: extend beyond the individual level, assess outcomes at organizational and systems levels, include objective measures of effect, assess baseline conditions, and evaluate features most critical to the success of interventions.

Hybrid plasmonic systems: from optical transparencies to strong coupling and entanglement

NASA Astrophysics Data System (ADS)

Gray, Stephen K.

2018-02-01

Classical electrodynamics and quantum mechanical models of quantum dots and molecules interacting with plasmonic systems are discussed. Calculations show that just one quantum dot interacting with a plasmonic system can lead to interesting optical effects, including optical transparencies and more general Fano resonance features that can be tailored with ultrafast laser pulses. Such effects can occur in the limit of moderate coupling between quantum dot and plasmonic system. The approach to the strong coupling regime is also discussed. In cases with two or more quantum dots within a plasmonic system, the possibility of quantum entanglement mediated through the dissipative plasmonic structure arises.

Altitude Effects on Thermal Ice Protection System Performance; A Study of an Alternative Simulation Approach

NASA Technical Reports Server (NTRS)

Addy, Gene; Wright, Bill; Orchard, David; Oleskiw, Myron

2015-01-01

The quest for more energy-efficient green aircraft, dictates that all systems, including the ice protection system (IPS), be closely examined for ways to reduce energy consumption and to increase efficiency. A thermal ice protection systems must protect the aircraft from the hazardous effects of icing, and yet it needs to do so as efficiently as possible. The system can no longer be afforded the degree of over-design in power usage they once were. To achieve these more exacting designs, a better understanding of the heat and mass transport phenomena involved during an icing encounter is needed.

30 CFR 48.28 - Annual refresher training of miners; minimum courses of instruction; hours of instruction.

Code of Federal Regulations, 2013 CFR

2013-07-01

... are related to the miner's tasks. (2) Transportation controls and communication systems. The course... effect for the transportation of miners and materials; and the use of the mine communication systems... firefighting. The course shall include a review of the mine escape system; escape and emergency evacuation...

30 CFR 48.28 - Annual refresher training of miners; minimum courses of instruction; hours of instruction.

Code of Federal Regulations, 2011 CFR

2011-07-01

... are related to the miner's tasks. (2) Transportation controls and communication systems. The course... effect for the transportation of miners and materials; and the use of the mine communication systems... firefighting. The course shall include a review of the mine escape system; escape and emergency evacuation...

30 CFR 48.28 - Annual refresher training of miners; minimum courses of instruction; hours of instruction.

Code of Federal Regulations, 2012 CFR

2012-07-01

... are related to the miner's tasks. (2) Transportation controls and communication systems. The course... effect for the transportation of miners and materials; and the use of the mine communication systems... firefighting. The course shall include a review of the mine escape system; escape and emergency evacuation...

30 CFR 48.28 - Annual refresher training of miners; minimum courses of instruction; hours of instruction.

Code of Federal Regulations, 2014 CFR

2014-07-01

... are related to the miner's tasks. (2) Transportation controls and communication systems. The course... effect for the transportation of miners and materials; and the use of the mine communication systems... firefighting. The course shall include a review of the mine escape system; escape and emergency evacuation...

78 FR 48632 - Releasing Information; General Provisions; Accounting and Reporting Requirements; Reports of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... the confidentiality of borrower information. The system of internal controls, at a minimum, must... and maintain an effective system of internal controls over the data included in the report of accounts... system of internal controls, at a minimum, must comply with the requirements of applicable Farm Credit...

Predicting Human Thermal Comfort in Automobiles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rugh, J.; Bharathan, D.; Chaney, L.

The objects of this report are to: (1) increase national energy security by reducing fuel use for vehicle climate control systems; (2) show/demonstrate technology that can reduce the fuel used by LD vehicles' ancillary systems; and (3) develop tools to evaluate the effectiveness of energy-efficient systems including--comfort, cost, practicality, ease-of-use, and reliability.

The Roles of Mental Animations and External Animations in Understanding Mechanical Systems

ERIC Educational Resources Information Center

Hegarty, Mary; Kriz, Sarah; Cate, Christina

2003-01-01

The effects of computer animations and mental animation on people's mental models of a mechanical system are examined. In 3 experiments, students learned how a mechanical system works from various instructional treatments including viewing a static diagram of the machine, predicting motion from static diagrams, viewing computer animations, and…

Implementation of Local Wellness Policies in Schools: Role of School Systems, School Health Councils, and Health Disparities

ERIC Educational Resources Information Center

Hager, Erin R.; Rubio, Diana S.; Eidel, G. Stewart; Penniston, Erin S.; Lopes, Megan; Saksvig, Brit I.; Fox, Renee E.; Black, Maureen M.

2016-01-01

Background: Written local wellness policies (LWPs) are mandated in school systems to enhance opportunities for healthy eating/activity. LWP effectiveness relies on school-level implementation. We examined factors associated with school-level LWP implementation. Hypothesized associations included system support for school-level implementation and…

Scaling up our understanding of non-consumptive effects in insect systems

DOE PAGES

Hermann, Sara L.; Landis, Douglas A.

2017-04-06

Here, non-consumptive effects (NCEs) of predators on prey is an important topic in insect ecology with potential applications for pest management. NCEs are changes in prey behavior and physiology that aid in predation avoidance. While NCEs can have positive outcomes for prey survival there may also be negative consequences including increased stress and reduced growth. These effects can cascade through trophic systems influencing ecosystem function. Most NCEs have been studied at small spatial and temporal scales. However, recent studies show promise for the potential to manipulate NCEs for pest management. We suggest the next frontier for NCE studies includes manipulatingmore » the landscape of fear to improve pest control, which requires scaling-up to field and landscape levels, over ecologically relevant time frames.« less

Scaling up our understanding of non-consumptive effects in insect systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hermann, Sara L.; Landis, Douglas A.

Here, non-consumptive effects (NCEs) of predators on prey is an important topic in insect ecology with potential applications for pest management. NCEs are changes in prey behavior and physiology that aid in predation avoidance. While NCEs can have positive outcomes for prey survival there may also be negative consequences including increased stress and reduced growth. These effects can cascade through trophic systems influencing ecosystem function. Most NCEs have been studied at small spatial and temporal scales. However, recent studies show promise for the potential to manipulate NCEs for pest management. We suggest the next frontier for NCE studies includes manipulatingmore » the landscape of fear to improve pest control, which requires scaling-up to field and landscape levels, over ecologically relevant time frames.« less

Method and apparatus for control of coherent synchrotron radiation effects during recirculation with bunch compression

DOEpatents

Douglas, David R; Tennant, Christopher

2015-11-10

A modulated-bending recirculating system that avoids CSR-driven breakdown in emittance compensation by redistributing the bending along the beamline. The modulated-bending recirculating system includes a) larger angles of bending in initial FODO cells, thereby enhancing the impact of CSR early on in the beam line while the bunch is long, and 2) a decreased bending angle in the final FODO cells, reducing the effect of CSR while the bunch is short. The invention describes a method for controlling the effects of CSR during recirculation and bunch compression including a) correcting chromatic aberrations, b) correcting lattice and CSR-induced curvature in the longitudinal phase space by compensating T.sub.566, and c) using lattice perturbations to compensate obvious linear correlations x-dp/p and x'-dp/p.

NASA's Earth Observing System Data and Information System - EOSDIS

NASA Technical Reports Server (NTRS)

Ramapriyan, Hampapuram K.

2011-01-01

This slide presentation reviews the work of NASA's Earth Observing System Data and Information System (EOSDIS), a petabyte-scale archive of environmental data that supports global climate change research. The Earth Science Data Systems provide end-to-end capabilities to deliver data and information products to users in support of understanding the Earth system. The presentation contains photographs from space of recent events, (i.e., the effects of the tsunami in Japan, and the wildfires in Australia.) It also includes details of the Data Centers that provide the data to EOSDIS and Science Investigator-led Processing Systems. Information about the Land, Atmosphere Near-real-time Capability for EOS (LANCE) and some of the uses that the system has made possible are reviewed. Also included is information about how to access the data, and evolutionary plans for the future of the system.

System Identification for the Clipper Liberty C96 Wind Turbine

NASA Astrophysics Data System (ADS)

Showers, Daniel

System identification techniques are powerful tools that help improve modeling capabilities of real world dynamic systems. These techniques are well established and have been successfully used on countless systems in many areas. However, wind turbines provide a unique challenge for system identification because of the difficulty in measuring its primary input: wind. This thesis first motivates the problem by demonstrating the challenges with wind turbine system identification using both simulations and real data. It then suggests techniques toward successfully identifying a dynamic wind turbine model including the notion of an effective wind speed and how it might be measured. Various levels of simulation complexity are explored for insights into calculating an effective wind speed. In addition, measurements taken from the University of Minnesota's Clipper Liberty C96 research wind turbine are used for a preliminary investigation into the effective wind speed calculation and system identification of a real world wind turbine.

Real World Data Driven Evolution of Volvo Cars’ Side Impact Protection Systems and their Effectiveness

PubMed Central

Jakobsson, Lotta; Lindman, Magdalena; Svanberg, Bo; Carlsson, Henrik

2010-01-01

This study analyses the outcome of the continuous improved occupant protection over the last two decades for front seat near side occupants in side impacts based on a real world driven working process. The effectiveness of four generations of improved side impact protection are calculated based on data from Volvo’s statistical accident database of Volvo Cars in Sweden. Generation I includes vehicles with a new structural and interior concept (SIPS). Generation II includes vehicles with structural improvements and a new chest airbag (SIPSbag). Generation III includes vehicles with further improved SIPS and SIPSbag as well as the new concept with a head protecting Inflatable Curtain (IC). Generation IV includes the most recent vehicles with further improvements of all the systems plus advanced sensors and seat belt pretensioner activation. Compared to baseline vehicles, vehicles of generation I reduce MAIS2+ injuries by 54%, generation II by 61% and generation III by 72%. For generation IV effectiveness figures cannot be calculated because of the lack of MAIS2+ injuries. A continuous improved performance is also seen when studying the AIS2+ pelvis, abdomen, chest and head injuries separately. By using the same real world driven working process, future improvements and possibly new passive as well as active safety systems, will be developed with the aim of further improved protection to near side occupants in side impacts. PMID:21050597

Effects of haloperidol on the behavioral, subjective, cognitive, motor, and neuroendocrine effects of Δ-9-tetrahydrocannabinol in humans

PubMed Central

Braley, Gabriel; Blaise, Rebecca; Vendetti, Michael; Oliver, Stephen; Pittman, Brian; Ranganathan, Mohini; Bhakta, Savita; Zimolo, Zoran; Cooper, Thomas; Perry, Edward

2010-01-01

Introduction Cannabinoids produce a spectrum of effects in humans including euphoria, cognitive impairments, psychotomimetic effects, and perceptual alterations. The extent to which dopaminergic systems contribute to the effects of Δ-9-tetrahydrocannabinol (Δ-9-THC) remains unclear. This study evaluated whether pretreatment with a dopamine receptor antagonist altered the effects of Δ-9-THC in humans. Materials and methods In a 2-test-day double-blind study, 28 subjects including healthy subjects (n=17) and frequent users of cannabis (n=11) were administered active (0.057 mg/kg) or placebo oral haloperidol in random order followed 90 and 215 min later by fixed order intravenous administration of placebo (vehicle) and active (0.0286 mg/kg) Δ-9-THC, respectively. Results Consistent with previous reports, intravenous Δ-9-THC produced psychotomimetic effects, perceptual alterations, and subjective effects including “high.” Δ-9-THC also impaired verbal recall and attention. Haloperidol pretreatment did not reduce any of the behavioral effects of Δ-9-THC. Haloperidol worsened the immediate free and delayed free and cued recall deficits produced by Δ-9-THC. Haloperidol and Δ-9-THC worsened distractibility and vigilance. Neither drug impaired performance on a motor screening task, the Stockings of Cambridge task, or the delayed match to sample task. Frequent users had lower baseline plasma prolactin levels and blunted Δ-9-THC induced memory impairments. Conclusions The deleterious effects of haloperidol pretreatment on the cognitive effects of Δ-9-THC are consistent with the preclinical literature in suggesting crosstalk between DAergic and CBergic systems. However, it is unlikely that DA D2 receptor mechanisms play a major role in mediating the psychotomimetic and perceptual altering effects of Δ-9-THC. Further investigation is warranted to understand the basis of the psychotomimetic effects of Δ-9-THC and to better understand the crosstalk between DAergic and CBergic systems. PMID:18228005

A modular approach for assessing the effect of radiation environments on man in operational systems. The radiobiological vulnerability of man during task performance

NASA Technical Reports Server (NTRS)

Ewing, D. E.

1972-01-01

A modular approach for assessing the affects of radiation environments on man in operational systems has been developed. The feasibility of the model has been proved and the practicality has been assessed. It has been applied to one operational system to date and information obtained has been submitted to systems analysts and mission planners for the assessment of man's vulnerability and impact on systems survivability. In addition, the model has been developed so that the radiobiological data can be input to a sophisticated man-machine interface model to properly relate the radiobiological stress with other mission stresses including the effects of a degraded system.

The Case for Diabetes Population Health Improvement: Evidence-Based Programming for Population Outcomes in Diabetes.

PubMed

Golden, Sherita Hill; Maruthur, Nisa; Mathioudakis, Nestoras; Spanakis, Elias; Rubin, Daniel; Zilbermint, Mihail; Hill-Briggs, Felicia

2017-07-01

The goal of this review is to describe diabetes within a population health improvement framework and to review the evidence for a diabetes population health continuum of intervention approaches, including diabetes prevention and chronic and acute diabetes management, to improve clinical and economic outcomes. Recent studies have shown that compared to usual care, lifestyle interventions in prediabetes lower diabetes risk at the population-level and that group-based programs have low incremental medial cost effectiveness ratio for health systems. Effective outpatient interventions that improve diabetes control and process outcomes are multi-level, targeting the patient, provider, and healthcare system simultaneously and integrate community health workers as a liaison between the patient and community-based healthcare resources. A multi-faceted approach to diabetes management is also effective in the inpatient setting. Interventions shown to promote safe and effective glycemic control and use of evidence-based glucose management practices include provider reminder and clinical decision support systems, automated computer order entry, provider education, and organizational change. Future studies should examine the cost-effectiveness of multi-faceted outpatient and inpatient diabetes management programs to determine the best financial models for incorporating them into diabetes population health strategies.

Hydrogen embrittlement of structural alloys. A technology survey

NASA Technical Reports Server (NTRS)

Carpenter, J. L., Jr.; Stuhrke, W. F.

1976-01-01

Technical abstracts for about 90 significant documents relating to hydrogen embrittlement of structural metals and alloys are reviewed. Particular note was taken of documents regarding hydrogen effects in rocket propulsion, aircraft propulsion and hydrogen energy systems, including storage and transfer systems.

The mobility and safety of walk-and-ride systems.

DOT National Transportation Integrated Search

2015-03-01

In this project we investigate the effect of traffic calming measures, such as crosswalks and sidewalks on the overall cost and safety of a multimodal transportation network system design. Our design problem includes auto, transit, and walking as mod...

Medical Information Management System (MIMS) CareWindows.

PubMed Central

Stiphout, R. M.; Schiffman, R. M.; Christner, M. F.; Ward, R.; Purves, T. M.

1991-01-01

The demonstration of MIMS/CareWindows will include: (1) a review of the application environment and development history, (2) a demonstration of a very large, comprehensive clinical information system with a cost effective graphic user server and communications interface. PMID:1807755

Technology and Freedom: Hope or Reality.

ERIC Educational Resources Information Center

Mumford, Enid

1995-01-01

Outlines the ETHICS methodology for workplace system design. This structured approach includes recognizing needs, setting objectives, choosing strategies, and evaluating results. Through user involvement, effective communication, and informed choice, ETHICS seeks to achieve greater realization of the advantages of new work systems. (JKP)

Nuclear decontamination technology evaluation to address contamination of a municipal water system

DOE Office of Scientific and Technical Information (OSTI.GOV)

McFee, J.; Langsted, J.; Young, M.

The US Environmental Protection Agency (EPA) and US Department of Homeland Security (DHS) are considering the impact and recovery from contamination of municipal water systems, including intentional contamination of those systems. Industrial chemicals, biological agents, drugs, pesticides, chemical warfare agents, and radionuclides all could be introduced into a municipal water system to create detrimental health effects and disrupt a community. Although unintentional, the 1993 cryptosporidium contamination of the Milwaukee WS water system resulted in 100 fatalities and disrupted the city for weeks. Shaw Environmental and Infrastructure Inc, (Shaw), as a subcontractor on a DHS contract with Michael Baker Jr., Inc.,more » was responsible for evaluation of the impact and recovery from radionuclide contamination in a municipal water system distribution system. Shaw was tasked to develop a matrix of nuclear industry decontamination technologies and evaluate applicability to municipal water systems. Shaw expanded the evaluation to include decontamination methods commonly used in the drinking water supply. The matrix compared all technologies for implementability, effectiveness, and cost. To address the very broad range of contaminants and contamination scenarios, Shaw bounded the problem by identification of specific contaminant release scenario(s) for specific water system architecture(s). A decontamination technology matrix was developed containing fifty-nine decontamination technologies potentially applicable to the water distribution system piping, pumps, tanks, associated equipment, and/or contaminated water. Qualitatively, the majority of the nuclear industry decontamination technologies were eliminated from consideration due to implementability concerns. However, inclusion of the municipal water system technologies supported recommendations that combined the most effective approaches in both industries. (authors)« less

Experiences and Lessons from Urban Health Insurance Reform in China.

PubMed

Xin, Haichang

2016-08-01

Health care systems often face competing goals and priorities, which make reforms challenging. This study analyzed factors influencing the success of a health care system based on urban health insurance reform evolution in China, and offers recommendations for improvement. Findings based on health insurance reform strategies and mechanisms that did or did not work can effectively inform improvement of health insurance system design and practice, and overall health care system performance, including equity, efficiency, effectiveness, cost, finance, access, and coverage, both in China and other countries. This study is the first to use historical comparison to examine the success and failure of China's health care system over time before and after the economic reform in the 1980s. This study is also among the first to analyze the determinants of Chinese health system effectiveness by relating its performance to both technical reasons within the health system and underlying nontechnical characteristics outside the health system, including socioeconomics, politics, culture, values, and beliefs. In conclusion, a health insurance system is successful when it fits its social environment, economic framework, and cultural context, which translates to congruent health care policies, strategies, organization, and delivery. No health system can survive without its deeply rooted socioeconomic environment and cultural context. That is why one society should be cautious not to radically switch from a successful model to an entirely different one over time. There is no perfect health system model suitable for every population-only appropriate ones for specific nations and specific populations at the right place and right time. (Population Health Management 2016;19:291-297).

[The effect of laryngoscopic surgery combined with nasal endoscopic system for the treatment of vocal cords benign lesions].

PubMed

Wang, Weian; Lu, Rong

2013-06-01

To investigate the effect of laryngoscopic surgery combined with nasal endoscopic system for the treatment of vocal cords benign lesions. Fifty-two patients admitted to our department with vocal cords benign lesions (including vocal polyps, vocal nodules, vocal cord cyst) underwent laryngoscopic surgery combined with nasal endoscopic system. All patients were treated successfully once and for all without any significant postoperative complication. The laryngoscopic surgery combined with nasal endoscopic system is a safe, minimally invasive and simple method for the treatment of benign lesions of vocal cords.

Fuel cell on-site integrated energy system parametric analysis of a residential complex

NASA Technical Reports Server (NTRS)

Simons, S. N.

1977-01-01

A parametric energy-use analysis was performed for a large apartment complex served by a fuel cell on-site integrated energy system (OS/IES). The variables parameterized include operating characteristics for four phosphoric acid fuel cells, eight OS/IES energy recovery systems, and four climatic locations. The annual fuel consumption for selected parametric combinations are presented and a breakeven economic analysis is presented for one parametric combination. The results show fuel cell electrical efficiency and system component choice have the greatest effect on annual fuel consumption; fuel cell thermal efficiency and geographic location have less of an effect.

Effects of energy conservation on equilibrium properties of hot asymmetric nuclear matter

NASA Astrophysics Data System (ADS)

Zhang, Zhen; Ko, Che Ming

2018-01-01

Based on the relativistic Vlasov-Uehling-Uhlenbeck transport model, which includes relativistic scalar and vector potentials on baryons, we consider an N -Δ -π system in a box with periodic boundary conditions to study the effects of energy conservation in particle production and absorption processes on the equilibrium properties of the system. The density and temperature of the matter in the box are taken to be similar to the hot dense matter formed in heavy ion collisions at intermediate energies. We find that to maintain the equilibrium numbers of N ,Δ , and π , which depend on the mean-field potentials of N and Δ , we must include these potentials in the energy conservation condition that determines the momenta of outgoing particles after a scattering or decay process. We further find that the baryon scalar potentials mainly affect the Δ and pion equilibrium numbers, while the baryon vector potentials have considerable effect on the effective charged pion ratio at equilibrium. Our results thus indicate that it is essential to include in the transport model the effect of potentials in the energy conservation of a scattering or decay process, which is ignored in most transport models, for studying pion production in heavy ion collisions.

Office of Inspector General Audit Report: Airport Certification Program

DOT National Transportation Integrated Search

1997-11-21

The objectives of the audit were to determine whether the Airport Certification : Program effectively and efficiently uses its resources to ensure airport safety : and whether there is an effective followup system, including adequate : enforcement ac...

Clinical decision support provided within physician order entry systems: a systematic review of features effective for changing clinician behavior.

PubMed

Kawamoto, Kensaku; Lobach, David F

2003-01-01

Computerized physician order entry (CPOE) systems represent an important tool for providing clinical decision support. In undertaking this systematic review, our objective was to identify the features of CPOE-based clinical decision support systems (CDSSs) most effective at modifying clinician behavior. For this review, two independent reviewers systematically identified randomized controlled trials that evaluated the effectiveness of CPOE-based CDSSs in changing clinician behavior. Furthermore, each included study was assessed for the presence of 14 CDSS features. We screened 10,023 citations and included 11 studies. Of the 10 studies comparing a CPOE-based CDSS intervention against a non-CDSS control group, 7 reported a significant desired change in professional practice. Moreover, meta-regression analysis revealed that automatic provision of the decision support was strongly associated with improved professional practice (adjusted odds ratio, 23.72; 95% confidence interval, 1.75-infiniti). Thus, we conclude that automatic provision of decision support is a critical feature of successful CPOE-based CDSS interventions.

Integrated management of major depression for people with cancer.

PubMed

Walker, Jane; Sharpe, Michael

2014-12-01

Major depression is an important complication of cancer. However, it is frequently inadequately treated. There are challenges both in identifying which cancer patients are depressed, and in ensuring that these patients receive effective treatment for their depression. Integration of depression management into cancer care has been advocated as a way to address these challenges. Such integrated approaches must include both the systematic identification of cases and the delivery of treatment. We describe here a system of depression care that includes both a screening programme to identify patients with depression and a linked treatment programme, based on the collaborative care model, called 'Depression Care for People with Cancer' (DCPC). The system of care was designed to be fully integrated with specialist cancer services and has been robustly evaluated in randomized trials. We describe how the system operates and explain why it is designed as it is. We also summarize the evidence for its effectiveness and cost-effectiveness and discuss its implementation in routine clinical practice.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sugama, H.; Nunami, M.; Department of Fusion Science, SOKENDAI

Effects of collisions on conservation laws for toroidal plasmas are investigated based on the gyrokinetic field theory. Associating the collisional system with a corresponding collisionless system at a given time such that the two systems have the same distribution functions and electromagnetic fields instantaneously, it is shown how the collisionless conservation laws derived from Noether's theorem are modified by the collision term. Effects of the external source term added into the gyrokinetic equation can be formulated similarly with the collisional effects. Particle, energy, and toroidal momentum balance equations including collisional and turbulent transport fluxes are systematically derived using a novelmore » gyrokinetic collision operator, by which the collisional change rates of energy and canonical toroidal angular momentum per unit volume in the gyrocenter space can be given in the conservative forms. The ensemble-averaged transport equations of particles, energy, and toroidal momentum given in the present work are shown to include classical, neoclassical, and turbulent transport fluxes which agree with those derived from conventional recursive formulations.« less

Chemical Interventions for Pain.

ERIC Educational Resources Information Center

Aronoff, Gerald M.; And Others

1986-01-01

Reviews properties and pharmacological effects of medications for pain, including peripherally acting analgesics, centrally acting narcotics, and adjuvant analgesics including antidepressants. Discusses the role of the endogenous opioid system in pain and depression. Explores clinical management issues in both inpatient and outpatient settings,…

28 CFR 90.52 - Eligible purposes.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., including the crimes of sexual assault and domestic violence; (2) Developing, training, or expanding units..., including the crimes of sexual assault and domestic violence; (3) Developing and implementing more effective... domestic violence; (4) Developing, installing, or expanding data collection and communication systems...

Education, Information Technology and Cognitive Science.

ERIC Educational Resources Information Center

Scaife, M.

1989-01-01

Discusses information technology and its effects on developmental psychology and children's education. Topics discussed include a theory of child-computer interaction (CCI); programing; communication and computers, including electronic mail; cognitive science; artificial intelligence; modeling the user-system interaction; and the future of…

Impact of gut microbiota on neurological diseases: Diet composition and novel treatments.

PubMed

Larroya-García, Ana; Navas-Carrillo, Diana; Orenes-Piñero, Esteban

2018-06-05

Gut microbiota has significant effects on the structure and function of the enteric and central nervous system including human behaviour and brain regulation. Herein, we analyze the role of this intestinal ecosystem, the effects of dietary changes and the administration of nutritional supplements, such as probiotics, prebiotics, or fecal transplantation in neuropsychiatric disorders. Numerous factors have been highlighted to influence gut microbiota composition, including genetics, health status, mode of birth delivery and environment. However, diet composition and nutritional status has been repeatedly shown to be one of the most critical modifiable factors of this ecosystem. A comprehensively analysis of the microbiome-intestine-brain axis has been performed, including the impact of intestinal bacteria in alterations in the nervous, immune and endocrine systems and their metabolites. Finally, we discuss the latest literature examining the effects of diet composition, nutritional status and microbiota alterations in several neuropsychiatric disorders, such as autism, anxiety, depression, Alzheimer's disease and anorexia nervosa.

Influence of oil-related environmental pollutants on female reproduction.

PubMed

Sirotkin, Alexander V; Harrath, Abdul Halim

2017-08-01

The petroleum low-weight aromatic hydrocarbons benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene, also known as BTEX, are among the most common hazardous sources of environmental contamination. This paper reviews the available data concerning the effects of BTEX on different aspects of female reproduction, including the fecundity, ovaries, central nervous system (CNS), oocytes, embryos, oviducts, cytogenetics of somatic and generative cells, intracellular signaling systems, and hypothalamic, pituitary and peripheral reproductive hormones. Analysis of the available literature demonstrates that BTEX can exert negative effects on various female reproductive sites, including the CNS-pituitary-ovarian axis, their signaling molecules and receptors, ovarian follicles, corpora lutea, oocytes, embryos, oviducts, ovarian cycles, fertility, and the viability of offspring. These effects could be due to the ability of BTEX to destroy chromosomes, to affect cell metabolism, including the accumulation of free radicals, and to affect the release of hormonal regulators of reproductive processes and intracellular protein kinases. Copyright © 2017 Elsevier Inc. All rights reserved.

From Programs to Systems: Deploying Implementation Science and Practice for Sustained Real World Effectiveness in Services for Children and Families.

PubMed

Ghate, Deborah

2016-01-01

The transfer of knowledge of effective practice, especially into "usual care" settings, remains challenging. This article argues that to close this gap we need to recognize the particular challenges of whole-system improvement. We need to move beyond a limited focus on individual programs and experimental research on their effectiveness. The rapidly developing field of implementation science and practice (ISP) provides a particular lens and a set of important constructs that can helpfully accelerate progress. A review of selected key constructs and distinctive features of ISP, including recognizing invisible system infrastructure, co-construction involving active collaboration between stakeholders, and attention to active implementation, supports for providers beyond education and training. Key aspects of an implementation lens likely to be most helpful in sustaining effectiveness include assisting innovators to identify and accommodate the architecture of existing systems, understand the implementation process as a series of distinct but nonlinear stages, identify implementation outcomes as prerequisites for treatment outcomes, and analyse implementation challenges using frameworks of implementation drivers. In complex adaptive systems, how services are implemented may matter more than their specific content, and how services align and adapt to local context may determine their sustained usefulness. To improve implementation-relevant research, we need better process evaluation and cannot rely on experimental methods that do not capture complex systemic contexts. Deployment of an implementation lens may perhaps help to avoid future "rigor mortis," enabling more productively flexible and integrative approaches to both program design and evaluation.

Lightning Instrumentation at KSC

NASA Technical Reports Server (NTRS)

Colon, Jose L.; Eng, D.

2003-01-01

This report summarizes lightning phenomena with a brief explanation of lightning generation and lightning activity as related to KSC. An analysis of the instrumentation used at launching Pads 39 A&B for measurements of lightning effects is included with alternatives and recommendations to improve the protection system and upgrade the actual instrumentation system. An architecture for a new data collection system to replace the present one is also included. A novel architecture to obtain lightning current information from several sensors using only one high speed recording channel while monitoring all sensors to replace the actual manual lightning current recorders and a novel device for the protection system are described.

Hand hygiene monitoring technology: protocol for a systematic review

PubMed Central

2013-01-01

Background Healthcare worker hand hygiene is thought to be one of the most important strategies to prevent healthcare-associated infections, but compliance is generally poor. Hand hygiene improvement interventions must include audits of compliance (almost always with feedback), which are most often done by direct observation - a method that is expensive, subjective, and prone to bias. New technologies, including electronic and video hand hygiene monitoring systems, have the potential to provide continuous and objective monitoring of hand hygiene, regular feedback, and for some systems, real-time reminders. We propose a systematic review of the evidence supporting the effectiveness of these systems. The primary objective is to determine whether hand hygiene monitoring systems yield sustainable improvements in hand hygiene compliance when compared to usual care. Methods/Design MEDLINE, EMBASE, CINAHL, and other relevant databases will be searched for randomized control studies and quasi-experimental studies evaluating a video or electronic hand hygiene monitoring system. A standard data collection form will be used to abstract relevant information from included studies. Bias will be assessed using the Cochrane Effective Practice and Organization of Care Group Risk of Bias Assessment Tool. Studies will be reviewed independently by two reviewers, with disputes resolved by a third reviewer. The primary outcome is directly observed hand hygiene compliance. Secondary outcomes include healthcare-associated infection incidence and improvements in hand hygiene compliance as measured by alternative metrics. Results will be qualitatively summarized with comparisons made between study quality, the measured outcome, and study-specific factors that may be expected to affect outcome (for example, study duration, frequency of feedback, use of real-time reminders). Meta-analysis will be performed if there is more than one study of similar systems with comparable outcome definitions. Discussion Electronic and video monitoring systems have the potential to improve hand hygiene compliance and prevent healthcare-associated infection, but are expensive, difficult to install and maintain, and may not be accepted by all healthcare workers. This review will assess the current evidence of effectiveness of these systems before their widespread adoption. Study registration PROSPERO registration number: CRD42013004519 PMID:24219817

Hand hygiene monitoring technology: protocol for a systematic review.

PubMed

Srigley, Jocelyn A; Lightfoot, David; Fernie, Geoff; Gardam, Michael; Muller, Matthew P

2013-11-12

Healthcare worker hand hygiene is thought to be one of the most important strategies to prevent healthcare-associated infections, but compliance is generally poor. Hand hygiene improvement interventions must include audits of compliance (almost always with feedback), which are most often done by direct observation - a method that is expensive, subjective, and prone to bias. New technologies, including electronic and video hand hygiene monitoring systems, have the potential to provide continuous and objective monitoring of hand hygiene, regular feedback, and for some systems, real-time reminders. We propose a systematic review of the evidence supporting the effectiveness of these systems. The primary objective is to determine whether hand hygiene monitoring systems yield sustainable improvements in hand hygiene compliance when compared to usual care. MEDLINE, EMBASE, CINAHL, and other relevant databases will be searched for randomized control studies and quasi-experimental studies evaluating a video or electronic hand hygiene monitoring system. A standard data collection form will be used to abstract relevant information from included studies. Bias will be assessed using the Cochrane Effective Practice and Organization of Care Group Risk of Bias Assessment Tool. Studies will be reviewed independently by two reviewers, with disputes resolved by a third reviewer. The primary outcome is directly observed hand hygiene compliance. Secondary outcomes include healthcare-associated infection incidence and improvements in hand hygiene compliance as measured by alternative metrics. Results will be qualitatively summarized with comparisons made between study quality, the measured outcome, and study-specific factors that may be expected to affect outcome (for example, study duration, frequency of feedback, use of real-time reminders). Meta-analysis will be performed if there is more than one study of similar systems with comparable outcome definitions. Electronic and video monitoring systems have the potential to improve hand hygiene compliance and prevent healthcare-associated infection, but are expensive, difficult to install and maintain, and may not be accepted by all healthcare workers. This review will assess the current evidence of effectiveness of these systems before their widespread adoption. PROSPERO registration number: CRD42013004519.

Brain Immune Interactions as the Basis of Gulf War Illness: Gulf War Illness Consortium (GWIC)

DTIC Science & Technology

2016-10-01

between the immune system and the brain. The GWIC includes both clinical ( human ) and preclinical (animal and cell) studies and researchers in the 10...47 pesticides , DFP, sarin 16. Price Code (Leave Bl k) 17. Security Classification of Report Unclassified 18. Security Classification of this...stronger and longer proinflammatory signaling effects between the immune system and the brain. The GWIC includes both clinical ( human ) and

Integrated Earth System Model (iESM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thornton, Peter Edmond; Mao, Jiafu; Shi, Xiaoying

2016-12-02

The iESM is a simulation code that represents the physical and biological aspects of Earth's climate system, and also includes the macro-economic and demographic properties of human societies. The human aspect of the simulation code is focused in particular on the effects of human activities on land use and land cover change, but also includes aspects such as energy economies. The time frame for predictions with iESM is approximately 1970 through 2100.

Development of an analysis for the determination of coupled helicopter rotor/control system dynamic response. Part 2: Program listing

NASA Technical Reports Server (NTRS)

Sutton, L. R.

1975-01-01

A theoretical analysis is developed for a coupled helicopter rotor system to allow determination of the loads and dynamic response behavior of helicopter rotor systems in both steady-state forward flight and maneuvers. The effects of an anisotropically supported swashplate or gyroscope control system and a deformed free wake on the rotor system dynamic response behavior are included.

Engineering performance metrics

NASA Astrophysics Data System (ADS)

Delozier, R.; Snyder, N.

1993-03-01

Implementation of a Total Quality Management (TQM) approach to engineering work required the development of a system of metrics which would serve as a meaningful management tool for evaluating effectiveness in accomplishing project objectives and in achieving improved customer satisfaction. A team effort was chartered with the goal of developing a system of engineering performance metrics which would measure customer satisfaction, quality, cost effectiveness, and timeliness. The approach to developing this system involved normal systems design phases including, conceptual design, detailed design, implementation, and integration. The lessons teamed from this effort will be explored in this paper. These lessons learned may provide a starting point for other large engineering organizations seeking to institute a performance measurement system accomplishing project objectives and in achieving improved customer satisfaction. To facilitate this effort, a team was chartered to assist in the development of the metrics system. This team, consisting of customers and Engineering staff members, was utilized to ensure that the needs and views of the customers were considered in the development of performance measurements. The development of a system of metrics is no different than the development of any type of system. It includes the steps of defining performance measurement requirements, measurement process conceptual design, performance measurement and reporting system detailed design, and system implementation and integration.

Simulator of Space Communication Networks

NASA Technical Reports Server (NTRS)

Clare, Loren; Jennings, Esther; Gao, Jay; Segui, John; Kwong, Winston

2005-01-01

Multimission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE) is a suite of software tools that simulates the behaviors of communication networks to be used in space exploration, and predict the performance of established and emerging space communication protocols and services. MACHETE consists of four general software systems: (1) a system for kinematic modeling of planetary and spacecraft motions; (2) a system for characterizing the engineering impact on the bandwidth and reliability of deep-space and in-situ communication links; (3) a system for generating traffic loads and modeling of protocol behaviors and state machines; and (4) a system of user-interface for performance metric visualizations. The kinematic-modeling system makes it possible to characterize space link connectivity effects, including occultations and signal losses arising from dynamic slant-range changes and antenna radiation patterns. The link-engineering system also accounts for antenna radiation patterns and other phenomena, including modulations, data rates, coding, noise, and multipath fading. The protocol system utilizes information from the kinematic-modeling and link-engineering systems to simulate operational scenarios of space missions and evaluate overall network performance. In addition, a Communications Effect Server (CES) interface for MACHETE has been developed to facilitate hybrid simulation of space communication networks with actual flight/ground software/hardware embedded in the overall system.

Geosynchronous platform definition study. Volume 4, Part 1: Traffic analysis and system requirements for the baseline traffic model

NASA Technical Reports Server (NTRS)

1973-01-01

The traffic analyses and system requirements data generated in the study resulted in the development of two traffic models; the baseline traffic model and the new traffic model. The baseline traffic model provides traceability between the numbers and types of geosynchronous missions considered in the study and the entire spectrum of missions foreseen in the total national space program. The information presented pertaining to the baseline traffic model includes: (1) definition of the baseline traffic model, including identification of specific geosynchronous missions and their payload delivery schedules through 1990; (2) Satellite location criteria, including the resulting distribution of the satellite population; (3) Geosynchronous orbit saturation analyses, including the effects of satellite physical proximity and potential electromagnetic interference; and (4) Platform system requirements analyses, including satellite and mission equipment descriptions, the options and limitations in grouping satellites, and on-orbit servicing criteria (both remotely controlled and man-attended).

Application of System Operational Effectiveness Methodology to Space Launch Vehicle Development and Operations

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Kelley, Gary W.

2012-01-01

The Department of Defense (DoD) defined System Operational Effectiveness (SOE) model provides an exceptional framework for an affordable approach to the development and operation of space launch vehicles and their supporting infrastructure. The SOE model provides a focal point from which to direct and measure technical effectiveness and process efficiencies of space launch vehicles. The application of the SOE model to a space launch vehicle's development and operation effort leads to very specific approaches and measures that require consideration during the design phase. This paper provides a mapping of the SOE model to the development of space launch vehicles for human exploration by addressing the SOE model key points of measurement including System Performance, System Availability, Technical Effectiveness, Process Efficiency, System Effectiveness, Life Cycle Cost, and Affordable Operational Effectiveness. In addition, the application of the SOE model to the launch vehicle development process is defined providing the unique aspects of space launch vehicle production and operations in lieu of the traditional broader SOE context that examines large quantities of fielded systems. The tailoring and application of the SOE model to space launch vehicles provides some key insights into the operational design drivers, capability phasing, and operational support systems.

Negative health system effects of Global Fund's investments in AIDS, tuberculosis and malaria from 2002 to 2009: systematic review.

PubMed

Car, Josip; Paljärvi, Tapio; Car, Mate; Kazeem, Ayodele; Majeed, Azeem; Atun, Rifat

2012-10-01

By using the Global Fund as a case example, we aim to critically evaluate the evidence generated from 2002 to 2009 for potential negative health system effects of Global Health Initiatives (GHI). Systematic review of research literature. Developing Countries. All interventions potentially affecting health systems that were funded by the Global Fund. Negative health system effects of Global Fund investments as reported by study authors. We identified 24 studies commenting on adverse effects on health systems arising from Global Fund investments. Sixteen were quantitative studies, six were qualitative and two used both quantitative and qualitative methods, but none explicitly stated that the studies were originally designed to capture or to assess health system effects (positive or negative). Only seemingly anecdotal evidence or authors' perceptions/interpretations of circumstances could be extracted from the included studies. This study shows that much of the currently available evidence generated between 2002 and 2009 on GHIs potential negative health system effects is not of the quality expected or needed to best serve the academic or broader community. The majority of the reviewed research did not fulfil the requirements of rigorous scientific evidence.

Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.

PubMed

Reichrath, Jörg; Saternus, Roman; Vogt, Thomas

2017-09-15

The skin represents a pivotal organ for the human body's vitamin D endocrine system, being both the site of ultraviolet (UV)-B-induced vitamin D synthesis and a target tissue for the pluripotent effects of 1,25(OH) 2 D 3 and other biologically active vitamin D metabolites. As many other steroid hormones, 1,25(OH) 2 D 3 exerts its effects via two independent signal transduction pathways: the classical genomic and the non-genomic pathway. While non-genomic effects of 1,25(OH) 2 D 3 are in part exerted via effects on intracellular calcium, genomic effects are mediated by the vitamin D receptor (VDR). Recent findings convincingly support the concept of a new function of the VDR as a tumor suppressor in skin, with key components of the vitamin D endocrine system, including VDR, CYP24A1, CYP27A1, and CYP27B1 being strongly expressed in non-melanoma skin cancer (NMSC). It has now been shown that anti-tumor effects of VDR, that include some of its ligand-induced growth-regulatory effects, are at least in part mediated by interacting in a highly coordinated manner with the p53 family (p53/p63/p73) in response to a large number of alterations in cell homeostasis, including UV-induced DNA damage, a hallmark for skin photocarcinogenesis. Considering the relevance of the vitamin D endocrine system for carcinogenesis of skin cancer, it is not surprising that low 25(OH)D serum concentrations and genetic variants (SNPs) of the vitamin D endocrine system have been identified as potential risk factors for occurrence and prognosis of skin malignancies. In conclusion, an increasing body of evidence now convincingly supports the concept that the vitamin D endocrine system is of relevance for photocarcinogenesis and progression of NMSC and that its pharmacologic modulation by vitamin D, 1,25(OH) 2 D 3, and analogs represents a promising new strategy for prevention and/or treatment of these malignancies. Copyright © 2017 Elsevier B.V. All rights reserved.

Automated and electronically assisted hand hygiene monitoring systems: a systematic review.

PubMed

Ward, Melissa A; Schweizer, Marin L; Polgreen, Philip M; Gupta, Kalpana; Reisinger, Heather S; Perencevich, Eli N

2014-05-01

Hand hygiene is one of the most effective ways to prevent transmission of health care-associated infections. Electronic systems and tools are being developed to enhance hand hygiene compliance monitoring. Our systematic review assesses the existing evidence surrounding the adoption and accuracy of automated systems or electronically enhanced direct observations and also reviews the effectiveness of such systems in health care settings. We systematically reviewed PubMed for articles published between January 1, 2000, and March 31, 2013, containing the terms hand AND hygiene or hand AND disinfection or handwashing. Resulting articles were reviewed to determine if an electronic system was used. We identified 42 articles for inclusion. Four types of systems were identified: electronically assisted/enhanced direct observation, video-monitored direct observation systems, electronic dispenser counters, and automated hand hygiene monitoring networks. Fewer than 20% of articles identified included calculations for efficiency or accuracy. Limited data are currently available to recommend adoption of specific automatic or electronically assisted hand hygiene surveillance systems. Future studies should be undertaken that assess the accuracy, effectiveness, and cost-effectiveness of such systems. Given the restricted clinical and infection prevention budgets of most facilities, cost-effectiveness analysis of specific systems will be required before these systems are widely adopted. Published by Mosby, Inc.

Environmental assessment for the satellite power system concept development and evaluation program: nonmicrowave health and ecological effects

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, M R

1980-11-01

A Concept Development and Evaluation Program is being carried out for a proposed Satellite Power System (SPS). For purposes of this evaluation, a preliminary reference system has been developed. SPS, as described in the reference system, would collect solar energy on satellites in geosychronous orbit in space. The energy would be converted to microwaves and beamed to an earth-receiving antenna (rectenna). One task in the environmental part of the program is the assessment of the nonmicrowave effects on health and the environment. These effects would result from all phases of SPS development and operation. This report covers the current knowledgemore » regarding these effects, and is based on the reference system. The assessment is summarized as to scope, methodology, impacts of terrestrial development, launch and recovery of spacecraft, space activities (including health effects of the space environment, ionizing radiation, electromagnetic exposure, spacecraft charging and environmental interactions, occupational hazards, etc.) and construction and operation of rectenna (ground receiving station).« less

[Effects of lycopene on the skeletal system].

PubMed

Sołtysiak, Patrycja; Folwarczna, Joanna

2015-02-21

Antioxidant substances of plant origin, such as lycopene, may favorably affect the skeletal system. Lycopene is a carotenoid pigment, responsible for characteristic red color of tomatoes. It is believed that lycopene may play a role in the prevention of various diseases; despite theoretical premises and results of experimental studies, the effectiveness of lycopene has not yet been clearly demonstrated in studies carried out in humans. The aim of the study was to present the current state of knowledge on the effects of lycopene on the osseous tissue in in vitro and in vivo experimental models and on the skeletal system in humans. Results of the studies indicate that lycopene may inhibit bone resorption. Favorable effects of high doses of lycopene on the rat skeletal system in experimental conditions, including the model of osteoporosis induced by estrogen deficiency, have been demonstrated. The few epidemiological and clinical studies, although not fully conclusive, suggest a possible beneficial effect of lycopene present in the diet on the skeletal system.

Early sound patterns in the speech of two Brazilian Portuguese speakers.

PubMed

Teixeira, Elizabeth Reis; Davis, Barbara L

2002-06-01

Sound patterns in the speech of two Brazilian-Portuguese speaking children are compared with early production patterns in English-learning children as well as English and Brazilian-Portuguese (BP) characteristics. The relationship between production system effects and ambient language influences in the acquisition of early sound patterns is of primary interest, as English and BP are characterized by differing phonological systems. Results emphasize the primacy of production system effects in early acquisition, although even the earliest word forms show evidence of perceptual effects from the ambient language in both BP children. Use of labials and coronals and low and midfront vowels in simple syllable shapes is consistent with acquisition data for this period across languages. However, potential ambient language influences include higher frequencies of dorsals, use of multisyllabic words, and different phone types in syllable-offset position. These results suggest that to fully understand early acquisition of sound systems one must account for both production system effects and perceptual effects from the ambient language.

X-Eye: a novel wearable vision system

NASA Astrophysics Data System (ADS)

Wang, Yuan-Kai; Fan, Ching-Tang; Chen, Shao-Ang; Chen, Hou-Ye

2011-03-01

This paper proposes a smart portable device, named the X-Eye, which provides a gesture interface with a small size but a large display for the application of photo capture and management. The wearable vision system is implemented with embedded systems and can achieve real-time performance. The hardware of the system includes an asymmetric dualcore processer with an ARM core and a DSP core. The display device is a pico projector which has a small volume size but can project large screen size. A triple buffering mechanism is designed for efficient memory management. Software functions are partitioned and pipelined for effective execution in parallel. The gesture recognition is achieved first by a color classification which is based on the expectation-maximization algorithm and Gaussian mixture model (GMM). To improve the performance of the GMM, we devise a LUT (Look Up Table) technique. Fingertips are extracted and geometrical features of fingertip's shape are matched to recognize user's gesture commands finally. In order to verify the accuracy of the gesture recognition module, experiments are conducted in eight scenes with 400 test videos including the challenge of colorful background, low illumination, and flickering. The processing speed of the whole system including the gesture recognition is with the frame rate of 22.9FPS. Experimental results give 99% recognition rate. The experimental results demonstrate that this small-size large-screen wearable system has effective gesture interface with real-time performance.

The effects of stimulated star formation on the evolution of the galaxy. III - The chemical evolution of nonlinear systems

NASA Technical Reports Server (NTRS)

Shore, Steven N.; Ferrini, Federico; Palla, Francesco

1987-01-01

The evolution of models for star formation in galaxies with disk and halo components is discussed. Two phases for the halo (gas and stars) and three for the disk (including clouds) are used in these calculations. The star-formation history is followed using nonlinear phase-coupling models which completely determine the populations of the phases as a function of time. It is shown that for a wide range of parameters, including the effects of both spontaneous and stimulated star formation and mass exchange between the spatial components of the system, the observed chemical history of the galaxy can easily be obtained. The most sensitive parameter in the detailed metallicity and star-formation history for the system is the rate of return of gas to the diffuse phase upon stellar death.

Cardiovascular disease prevention and health promotion with the transcendental meditation program and Maharishi consciousness-based health care.

PubMed

Schneider, Robert H; Walton, Kenneth G; Salerno, John W; Nidich, Sanford I

2006-01-01

This article summarizes the background, rationale, and clinical research on a traditional system of natural health care that may be useful in the prevention of cardiovascular disease (CVD) and promotion of health. Results recently reported include reductions in blood pressure, psychosocial stress, surrogate markers for atherosclerotic CVD, and mortality. The randomized clinical trials conducted so far have involved applications to both primary and secondary prevention as well as to health promotion more generally. The results support the applicability of this approach for reducing ethnic health disparities associated with environmental and psychosocial stress. Proposed mechanisms for the effects of this traditional system include enhanced resistance to physiological and psychological stress and improvements in homeostatic and self-repair processes. This system may offer clinical and cost effectiveness advantages for health care, particularly in preventive cardiology.

Systemic and localized scleroderma.

PubMed

Chung, Lorinda; Lin, Jan; Furst, Daniel E; Fiorentino, David

2006-01-01

Sclerosing conditions of the skin are manifested by a full spectrum of presentations that includes skin-limited forms as well as those which can involve internal organs and result in death. At this point, we are just beginning to understand the mechanisms of tissue fibrosis, and it is likely that the fibrotic processes are a heterogeneous group of disorders in which perturbation of multiple molecular pathways, including vascular and immunologically mediated pathways, can lead to fibrosis. We now have some moderately effective therapies for vascular aspects of systemic sclerosis (eg, bosentan for pulmonary arterial hypertension, calcium-channel blockers for Raynaud's, or angiotensin-converting enzyme inhibitors for renal crisis). We also are beginning to find treatments interrupting the immunologic pathways that manifest as systemic sclerosis (eg, methotrexate for the skin or cyclophosphamide for the lungs). The basic process of fibrosis, however, awaits proven, effective therapy.

Method and apparatus for effecting light-off of a catalytic converter in a hybrid powertrain system

DOEpatents

Roos, Bryan Nathaniel; Spohn, Brian L

2013-07-02

A powertrain system includes a hybrid transmission and an internal combustion engine coupled to an exhaust aftertreatment device. A method for operating the powertrain system includes operating the hybrid transmission to generate tractive torque responsive to an operator torque request with the internal combustion engine in an engine-off state so long as the tractive torque is less than a threshold. The internal combustion engine is operated in an engine-on state at preferred operating conditions to effect light-off of the exhaust aftertreatment device and the hybrid transmission is coincidentally operated to generate tractive torque responsive to the operator torque request when the operator torque request exceeds the threshold. The internal combustion engine is then operated in the engine-on state to generate tractive torque responsive to the operator torque request.

Control-structure interaction/mirror motion compensation

NASA Technical Reports Server (NTRS)

Mclaren, Mark; Chu, Peter; Price, Xen

1992-01-01

Space Systems/Loral (formerly Ford Aerospace, Space Systems Division) has implemented a rigid-body Mirror Motion Compensation (MMC) scheme for the GOES-I/M spacecraft currently being built for NASA and NOAA. This has resulted in a factor of 15 reduction in pointing error due to rigid-body spacecraft motion induced by the periodic black-body calibration maneuvers required for the instruments. For GOES the spacecraft and the payload mirrors are considered as rigid bodies. The structural flexibility effects are small and are included in the total pointing budget as a separate item. This paper extends the MMC technique to include structural flexibility. For large multi-payload platforms, the structural flexibility effects can be more important in sensor pointing jitter as the result of payload motion. Sensitivity results are included to show the importance of the dynamic model fidelity.

Systemic delivery of β-blockers via transdermal route for hypertension

PubMed Central

Ahad, Abdul; Al-Jenoobi, Fahad I.; Al-Mohizea, Abdullah M.; Akhtar, Naseem; Raish, Mohammad; Aqil, Mohd.

2014-01-01

Hypertension is the most common cardiovascular disease worldwide. Moreover, management of hypertension requires long-term treatment that may result in poor patient compliance with conventional dosage forms due to greater frequency of drug administration. Although there is availability of a plethora of therapeutically effective antihypertensive molecules, inadequate patient welfare is observed; this arguably presents an opportunity to deliver antihypertensive agents through a different route. Ever since the transdermal drug delivery came into existence, it has offered great advantages including non-invasiveness, prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Attempts were made to develop the transdermal therapeutic system for various antihypertensive agents, including β-blockers, an important antihypertensive class. β-blockers are potent, highly effective in the management of hypertension and other heart ailments by blocking the effects of normal amounts of adrenaline in the heart and blood vessels. The shortcomings associated with β-blockers such as more frequent dose administration, extensive first pass metabolism and variable bioavailability, make them an ideal candidate for transdermal therapeutic systems. The present article gives a brief view of different β-blockers formulated as transdermal therapeutic system in detail to enhance the bioavailability as well as to improve patient compliance. Constant improvement in this field holds promise for the long-term success in technologically advanced transdermal dosage forms being commercialized sooner rather than later. PMID:26702253

Shifting the paradigm of music instruction: implications of embodiment stemming from an augmented reality guitar learning system

PubMed Central

Keebler, Joseph R.; Wiltshire, Travis J.; Smith, Dustin C.; Fiore, Stephen M.; Bedwell, Jeffrey S.

2014-01-01

Musical instruction often includes materials that can act as a barrier to learning. New technologies using augmented reality may aid in reducing the initial difficulties involved in learning music by lowering these barriers characteristic of traditional instructional materials. Therefore, this set of studies examined a novel augmented reality guitar learning system (i.e., the Fretlight® guitar) in regards to current theories of embodied music cognition. Specifically, we examined the effects of using this system in comparison to a standard instructional material (i.e., diagrams). First, we review major theories related to musical embodiment and specify a niche within this research space we call embodied music technology for learning. Following, we explicate two parallel experiments that were conducted to address the learning effects of this system. Experiment 1 examined short-term learning effects within one experimental session, while Experiment 2 examined both short-term and long-term effects across two sessions spaced at a 2-week interval. Analyses demonstrated that, for many of our dependent variables, all participants increased in performance across time. Further, the Fretlight® condition consistently led to significantly better outcomes via interactive effects, including significantly better long term retention for the learned information across a 2 week time interval. These results are discussed in the context of embodied cognition theory as it relates to music. Potential limitations and avenues for future research are described. PMID:24999334

Nail Psoriasis: A Review of Treatment Options.

PubMed

Pasch, Marcel C

2016-04-01

Nail involvement affects 80-90 % of patients with plaque psoriasis, and is even more prevalent in patients with psoriatic arthritis. This review is the result of a systemic approach to the literature and covers topical, intralesional, conventional systemic, and biologic systemic treatments, as well as non-pharmacological treatment options for nail psoriasis. The available evidence suggests that all anti-tumor necrosis factor-α, anti-interleukin (IL)-17, and anti-IL-12/23 antibodies which are available for plaque psoriasis and psoriatic arthritis are highly effective treatments for nail psoriasis. Conventional systemic treatments, including methotrexate, cyclosporine, acitretin, and apremilast, as well as intralesional corticosteroids, can also be effective treatments for nail psoriasis. Topical treatments, including corticosteroids, calcipotriol, tacrolimus, and tazarotene, have also been shown to have a position in the treatment of nail psoriasis, particularly in mild cases. Finally, non-pharmacological treatment options, including phototherapy, photodynamic therapy, laser therapy, and several radiotherapeutic options, are also reviewed but cannot be advised as first-line treatment options. Another conclusion of this review is that the lack of a reliable core set of outcomes measures for trials in nail psoriasis hinders the interpretation of results, and is urgently needed.