X-34 Main Propulsion System-Selected Subsystem Analyses

NASA Technical Reports Server (NTRS)

Brown, T. M.; McDonald, J. P.; Knight, K. C.; Champion, R. H., Jr.

1998-01-01

The X-34 hypersonic flight vehicle is currently under development by Orbital Sciences Corporation (Orbital). The Main Propulsion System (MPS) has been designed around the liquid propellant Fastrac rocket engine currently under development at NASA Marshall Space Flight Center. This paper presents selected analyses of MPS subsystems and components. Topics include the integration of component and system level modeling of the LOX dump subsystem and a simple terminal bubble velocity analysis conducted to guide propellant feed line design.

Probabilistic, Decision-theoretic Disease Surveillance and Control

PubMed Central

Wagner, Michael; Tsui, Fuchiang; Cooper, Gregory; Espino, Jeremy U.; Harkema, Hendrik; Levander, John; Villamarin, Ricardo; Voorhees, Ronald; Millett, Nicholas; Keane, Christopher; Dey, Anind; Razdan, Manik; Hu, Yang; Tsai, Ming; Brown, Shawn; Lee, Bruce Y.; Gallagher, Anthony; Potter, Margaret

2011-01-01

The Pittsburgh Center of Excellence in Public Health Informatics has developed a probabilistic, decision-theoretic system for disease surveillance and control for use in Allegheny County, PA and later in Tarrant County, TX. This paper describes the software components of the system and its knowledge bases. The paper uses influenza surveillance to illustrate how the software components transform data collected by the healthcare system into population level analyses and decision analyses of potential outbreak-control measures. PMID:23569617

Plant Systems Biology at the Single-Cell Level.

PubMed

Libault, Marc; Pingault, Lise; Zogli, Prince; Schiefelbein, John

2017-11-01

Our understanding of plant biology is increasingly being built upon studies using 'omics and system biology approaches performed at the level of the entire plant, organ, or tissue. Although these approaches open new avenues to better understand plant biology, they suffer from the cellular complexity of the analyzed sample. Recent methodological advances now allow plant scientists to overcome this limitation and enable biological analyses of single-cells or single-cell-types. Coupled with the development of bioinformatics and functional genomics resources, these studies provide opportunities for high-resolution systems analyses of plant phenomena. In this review, we describe the recent advances, current challenges, and future directions in exploring the biology of single-cells and single-cell-types to enhance our understanding of plant biology as a system. Copyright © 2017 Elsevier Ltd. All rights reserved.

Life cycle assessment for optimising the level of separated collection in integrated MSW management systems.

PubMed

Rigamonti, L; Grosso, M; Giugliano, M

2009-02-01

This life cycle assessment study analyses material and energy recovery within integrated municipal solid waste (MSW) management systems, and, in particular, the recovery of the source-separated materials (packaging and organic waste) and the energy recovery from the residual waste. The recovery of materials and energy are analysed together, with the final aim to evaluate possible optimum levels of source-separated collection that lead to the most favourable energetic and environmental results; this method allows identification of an optimum configuration of the MSW management system. The results show that the optimum level of source-separated collection is about 60%, when all the materials are recovered with high efficiency; it decreases to about 50%, when the 60% level is reached as a result of a very high recovery efficiency for organic fractions at the expense of the packaging materials, or when this implies an appreciable reduction of the quality of collected materials. The optimum MSW management system is thus characterized by source-separated collection levels as included in the above indicated range, with subsequent recycling of the separated materials and energy recovery of the residual waste in a large-scale incinerator operating in combined heat and power mode.

Congruence between the courses of the biliary ductal and the hepatic arterial systems.

PubMed

Mlakar, Bostjan; Gadzijev, Eldar M; Ravnik, Dean; Hribernik, Marija

2005-07-01

The development of diagnostic methods and new surgical techniques means it is increasingly important to have accurate knowledge of the anatomy of the hepatic arterial and biliary systems, including their variations, at extrahepatic and intrahepatic levels. The aim of this study was to determine how often the biliary and arterial systems run together and branch in the same pattern. Fifty corrosion casts of the liver were used to analyse the origin and branching patterns of arteries and the confluences of bile ducts. In addition, both systems were analysed to determine the frequency of normal arrangements and variations. The congruence of the course of both systems was analysed at the porta hepatis and in the left and right hemilivers down to the segmental level. A congruent course of the arterial and the biliary systems was identified in 38% of cases at the porta hepatis, in 32% of cases in the left hemiliver and in 30% of the right hemiliver. The congruence of both systems at the porta hepatis and in the left hemiliver was identified only if both systems were normal. In the right hemiliver, however, the congruence of both systems was identified even when both systems were variable, but only in 10% of cases. The results of the study show that, on the basis of knowledge of the course and branching of one system, the other system cannot be predicted.

Ecological hierarchies and self-organisation - Pattern analysis, modelling and process integration across scales

USGS Publications Warehouse

Reuter, H.; Jopp, F.; Blanco-Moreno, J. M.; Damgaard, C.; Matsinos, Y.; DeAngelis, D.L.

2010-01-01

A continuing discussion in applied and theoretical ecology focuses on the relationship of different organisational levels and on how ecological systems interact across scales. We address principal approaches to cope with complex across-level issues in ecology by applying elements of hierarchy theory and the theory of complex adaptive systems. A top-down approach, often characterised by the use of statistical techniques, can be applied to analyse large-scale dynamics and identify constraints exerted on lower levels. Current developments are illustrated with examples from the analysis of within-community spatial patterns and large-scale vegetation patterns. A bottom-up approach allows one to elucidate how interactions of individuals shape dynamics at higher levels in a self-organisation process; e.g., population development and community composition. This may be facilitated by various modelling tools, which provide the distinction between focal levels and resulting properties. For instance, resilience in grassland communities has been analysed with a cellular automaton approach, and the driving forces in rodent population oscillations have been identified with an agent-based model. Both modelling tools illustrate the principles of analysing higher level processes by representing the interactions of basic components.The focus of most ecological investigations on either top-down or bottom-up approaches may not be appropriate, if strong cross-scale relationships predominate. Here, we propose an 'across-scale-approach', closely interweaving the inherent potentials of both approaches. This combination of analytical and synthesising approaches will enable ecologists to establish a more coherent access to cross-level interactions in ecological systems. ?? 2010 Gesellschaft f??r ??kologie.

Bad Behavior: Improving Reproducibility in Behavior Testing.

PubMed

Andrews, Anne M; Cheng, Xinyi; Altieri, Stefanie C; Yang, Hongyan

2018-01-24

Systems neuroscience research is increasingly possible through the use of integrated molecular and circuit-level analyses. These studies depend on the use of animal models and, in many cases, molecular and circuit-level analyses. Associated with genetic, pharmacologic, epigenetic, and other types of environmental manipulations. We illustrate typical pitfalls resulting from poor validation of behavior tests. We describe experimental designs and enumerate controls needed to improve reproducibility in investigating and reporting of behavioral phenotypes.

The UK Earth System Models Marine Biogeochemical Evaluation Toolkit, BGC-val

NASA Astrophysics Data System (ADS)

de Mora, Lee

2017-04-01

The Biogeochemical Validation toolkit, BGC-val, is a model and grid independent python-based marine model evaluation framework that automates much of the validation of the marine component of an Earth System Model. BGC-val was initially developed to be a flexible and extensible system to evaluate the spin up of the marine UK Earth System Model (UKESM). However, the grid-independence and flexibility means that it is straightforward to adapt the BGC-val framework to evaluate other marine models. In addition to the marine component of the UKESM, this toolkit has been adapted to compare multiple models, including models from the CMIP5 and iMarNet inter-comparison projects. The BGC-val toolkit produces multiple levels of analysis which are presented in a simple to use interactive html5 document. Level 1 contains time series analyses, showing the development over time of many important biogeochemical and physical ocean metrics, such as the Global primary production or the Drake passage current. The second level of BGC-val is an in-depth spatial analyses of a single point in time. This is a series of point to point comparison of model and data in various regions, such as a comparison of Surface Nitrate in the model vs data from the world ocean atlas. The third level analyses are specialised ad-hoc packages to go in-depth on a specific question, such as the development of Oxygen minimum zones in the Equatorial Pacific. In additional to the three levels, the html5 document opens with a Level 0 table showing a summary of the status of the model run. The beta version of this toolkit is available via the Plymouth Marine Laboratory Gitlab server and uses the BSD 3 clause license.

Space transfer concepts and analysis for exploration missions. Implementation plan and element description document. Volume 1: Major trades. Book 1: Draft final

NASA Technical Reports Server (NTRS)

1991-01-01

This document presents trade studies and reference concept designs accomplished during a study of Space Transfer Concepts and Analyses for Exploration Missions (STCAEM). This volume contains the major top level trades, level 2 trades conducted in support of NASA's Lunar/Mars Exploration Program Office, and a synopsis of the vehicles for different propulsion systems under trade consideration. The vehicles are presented in more detail in other volumes of this report. Book 1 of Volume 1 covers the following analyses: lunar/Mars commonality trades, lunar/Mars mission operations, and Mars transfer systems.

Advancement of Bi-Level Integrated System Synthesis (BLISS)

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, Jaroslaw; Emiley, Mark S.; Agte, Jeremy S.; Sandusky, Robert R., Jr.

2000-01-01

Bi-Level Integrated System Synthesis (BLISS) is a method for optimization of an engineering system, e.g., an aerospace vehicle. BLISS consists of optimizations at the subsystem (module) and system levels to divide the overall large optimization task into sets of smaller ones that can be executed concurrently. In the initial version of BLISS that was introduced and documented in previous publications, analysis in the modules was kept at the early conceptual design level. This paper reports on the next step in the BLISS development in which the fidelity of the aerodynamic drag and structural stress and displacement analyses were upgraded while the method's satisfactory convergence rate was retained.

Designing Domain-Specific HUMS Architectures: An Automated Approach

NASA Technical Reports Server (NTRS)

Mukkamala, Ravi; Agarwal, Neha; Kumar, Pramod; Sundaram, Parthiban

2004-01-01

The HUMS automation system automates the design of HUMS architectures. The automated design process involves selection of solutions from a large space of designs as well as pure synthesis of designs. Hence the whole objective is to efficiently search for or synthesize designs or parts of designs in the database and to integrate them to form the entire system design. The automation system adopts two approaches in order to produce the designs: (a) Bottom-up approach and (b) Top down approach. Both the approaches are endowed with a Suite of quantitative and quantitative techniques that enable a) the selection of matching component instances, b) the determination of design parameters, c) the evaluation of candidate designs at component-level and at system-level, d) the performance of cost-benefit analyses, e) the performance of trade-off analyses, etc. In short, the automation system attempts to capitalize on the knowledge developed from years of experience in engineering, system design and operation of the HUMS systems in order to economically produce the most optimal and domain-specific designs.

Peritoneal Dialysate Glucose Load and Systemic Glucose Metabolism in Non-Diabetics: Results from the GLOBAL Fluid Cohort Study

PubMed Central

Chess, James; Do, Jun-Young; Noh, Hyunjin; Lee, Hi-Bahl; Kim, Yong-Lim; Summers, Angela; Williams, Paul Ford; Davison, Sara; Dorval, Marc

2016-01-01

Background and Objectives Glucose control is a significant predictor of mortality in diabetic peritoneal dialysis (PD) patients. During PD, the local toxic effects of intra-peritoneal glucose are well recognized, but despite large amounts of glucose being absorbed, the systemic effects of this in non-diabetic patients are not clear. We sought to clarify whether dialysate glucose has an effect upon systemic glucose metabolism. Methods and Materials We analysed the Global Fluid Study cohort, a prospective, observational cohort study initiated in 2002. A subset of 10 centres from 3 countries with high data quality were selected (368 incident and 272 prevalent non-diabetic patients), with multilevel, multivariable analysis of the reciprocal of random glucose levels, and a stratified-by-centre Cox survival analysis. Results The median follow up was 5.6 and 6.4 years respectively in incident and prevalent patients. On multivariate analysis, serum glucose increased with age (β = -0.007, 95%CI -0.010, -0.004) and decreased with higher serum sodium (β = 0.002, 95%CI 0.0005, 0.003) in incident patients and increased with dialysate glucose (β = -0.0002, 95%CI -0.0004, -0.00006) in prevalent patients. Levels suggested undiagnosed diabetes in 5.4% of prevalent patients. Glucose levels predicted death in unadjusted analyses of both incident and prevalent groups but in an adjusted survival analysis they did not (for random glucose 6–10 compared with <6, Incident group HR 0.92, 95%CI 0.58, 1.46, Prevalent group HR 1.42, 95%CI 0.86, 2.34). Conclusions In prevalent non-diabetic patients, random glucose levels at a diabetic level are under-recognised and increase with dialysate glucose load. Random glucose levels predict mortality in unadjusted analyses, but this association has not been proven in adjusted analyses. PMID:27249020

Advanced space program studies: Overall executive summary

NASA Technical Reports Server (NTRS)

Sitney, L. R.

1974-01-01

Studies were conducted to provide NASA with advanced planning analyses which relate integrated space program goals and options to credible technical capabilities, applications potential, and funding resources. The studies concentrated on the following subjects: (1) upper stage options for the space transportation system based on payload considerations, (2) space servicing and standardization of payloads, (3) payload operations, and (4) space transportation system economic analyses related to user charges and new space applications. A systems cost/performance model was developed to synthesize automated, unmanned spacecraft configurations based on the system requirements and a list of equipments at the assembly level.

Thermal control requirements for large space structures

NASA Technical Reports Server (NTRS)

Manoff, M.

1978-01-01

Performance capabilities and weight requirements of large space structure systems will be significantly influenced by thermal response characteristics. Analyses have been performed to determine temperature levels and gradients for structural configurations and elemental concepts proposed for advanced system applications ranging from relatively small, low-power communication antennas to extremely large, high-power Satellite Power Systems (SPS). Results are presented for selected platform configurations, candidate strut elements, and potential mission environments. The analyses also incorporate material and surface optical property variation. The results illustrate many of the thermal problems which may be encountered in the development of three systems.

A detailed view on sulphur metabolism at the cellular and whole-plant level illustrates challenges in metabolite flux analyses.

PubMed

Rennenberg, Heinz; Herschbach, Cornelia

2014-11-01

Understanding the dynamics of physiological process in the systems biology era requires approaches at the genome, transcriptome, proteome, and metabolome levels. In this context, metabolite flux experiments have been used in mapping metabolite pathways and analysing metabolic control. In the present review, sulphur metabolism was taken to illustrate current challenges of metabolic flux analyses. At the cellular level, restrictions in metabolite flux analyses originate from incomplete knowledge of the compartmentation network of metabolic pathways. Transport of metabolites through membranes is usually not considered in flux experiments but may be involved in controlling the whole pathway. Hence, steady-state and snapshot readings need to be expanded to time-course studies in combination with compartment-specific metabolite analyses. Because of species-specific differences, differences between tissues, and stress-related responses, the quantitative significance of different sulphur sinks has to be elucidated; this requires the development of methods for whole-sulphur metabolome approaches. Different cell types can contribute to metabolite fluxes to different extents at the tissue and organ level. Cell type-specific analyses are needed to characterize these contributions. Based on such approaches, metabolite flux analyses can be expanded to the whole-plant level by considering long-distance transport and, thus, the interaction of roots and the shoot in metabolite fluxes. However, whole-plant studies need detailed empirical and mathematical modelling that have to be validated by experimental analyses. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Modular space station phase B extension, preliminary system design. Volume 4: Subsystems analyses

NASA Technical Reports Server (NTRS)

Antell, R. W.

1972-01-01

The subsystems tradeoffs, analyses, and preliminary design results are summarized. Analyses were made of the structural and mechanical, environmental control and life support, electrical power, guidance and control, reaction control, information, and crew habitability subsystems. For each subsystem a summary description is presented including subsystem requirements, subsystem description, and subsystem characteristics definition (physical, performance, and interface). The major preliminary design data and tradeoffs or analyses are described in detail at each of the assembly levels.

Barriers to healthcare coordination in market-based and decentralized public health systems: a qualitative study in healthcare networks of Colombia and Brazil

PubMed Central

Vargas, Ingrid; Mogollón-Pérez, Amparo Susana; De Paepe, Pierre; Ferreira da Silva, Maria Rejane; Unger, Jean-Pierre; Vázquez, María-Luisa

2016-01-01

Although integrated healthcare networks (IHNs) are promoted in Latin America in response to health system fragmentation, few analyses on the coordination of care across levels in these networks have been conducted in the region. The aim is to analyse the existence of healthcare coordination across levels of care and the factors influencing it from the health personnel’ perspective in healthcare networks of two countries with different health systems: Colombia, with a social security system based on managed competition and Brazil, with a decentralized national health system. A qualitative, exploratory and descriptive–interpretative study was conducted, based on a case study of healthcare networks in four municipalities. Individual semi-structured interviews were conducted with a three stage theoretical sample of (a) health (112) and administrative (66) professionals of different care levels, and (b) managers of providers (42) and insurers (14). A thematic content analysis was conducted, segmented by cases, informant groups and themes. The results reveal poor clinical information transfer between healthcare levels in all networks analysed, with added deficiencies in Brazil in the coordination of access and clinical management. The obstacles to care coordination are related to the organization of both the health system and the healthcare networks. In the health system, there is the existence of economic incentives to compete (exacerbated in Brazil by partisan political interests), the fragmentation and instability of networks in Colombia and weak planning and evaluation in Brazil. In the healthcare networks, there are inadequate working conditions (temporary and/or part-time contracts) which hinder the use of coordination mechanisms, and inadequate professional training for implementing a healthcare model in which primary care should act as coordinator in patient care. Reforms are needed in these health systems and networks in order to modify incentives, strengthen the state planning and supervision functions and improve professional working conditions and skills. PMID:26874327

Testing a Coupled Global-limited-area Data Assimilation System using Observations from the 2004 Pacific Typhoon Season

NASA Astrophysics Data System (ADS)

Holt, C. R.; Szunyogh, I.; Gyarmati, G.; Hoffman, R. N.; Leidner, M.

2011-12-01

Tropical cyclone (TC) track and intensity forecasts have improved in recent years due to increased model resolution, improved data assimilation, and the rapid increase in the number of routinely assimilated observations over oceans. The data assimilation approach that has received the most attention in recent years is Ensemble Kalman Filtering (EnKF). The most attractive feature of the EnKF is that it uses a fully flow-dependent estimate of the error statistics, which can have important benefits for the analysis of rapidly developing TCs. We implement the Local Ensemble Transform Kalman Filter algorithm, a vari- ation of the EnKF, on a reduced-resolution version of the National Centers for Environmental Prediction (NCEP) Global Forecast System (GFS) model and the NCEP Regional Spectral Model (RSM) to build a coupled global-limited area anal- ysis/forecast system. This is the first time, to our knowledge, that such a system is used for the analysis and forecast of tropical cyclones. We use data from summer 2004 to study eight tropical cyclones in the Northwest Pacific. The benchmark data sets that we use to assess the performance of our system are the NCEP Reanalysis and the NCEP Operational GFS analyses from 2004. These benchmark analyses were both obtained by the Statistical Spectral Interpolation, which was the operational data assimilation system of NCEP in 2004. The GFS Operational analysis assimilated a large number of satellite radiance observations in addition to the observations assimilated in our system. All analyses are verified against the Joint Typhoon Warning Center Best Track data set. The errors are calculated for the position and intensity of the TCs. The global component of the ensemble-based system shows improvement in po- sition analysis over the NCEP Reanalysis, but shows no significant difference from the NCEP operational analysis for most of the storm tracks. The regional com- ponent of our system improves position analysis over all the global analyses. The intensity analyses, measured by the minimum sea level pressure, are of similar quality in all of the analyses. Regional deterministic forecasts started from our analyses are generally not significantly different from those started from the GFS operational analysis. On average, the regional experiments performed better for longer than 48 h sea level pressure forecasts, while the global forecast performed better in predicting the position for longer than 48 h.

Control, responses and modularity of cellular regulatory networks: a control analysis perspective.

PubMed

Bruggeman, F J; Snoep, J L; Westerhoff, H V

2008-11-01

Cells adapt to changes in environmental conditions through the concerted action of signalling, gene expression and metabolic subsystems. The authors will discuss a theoretical framework addressing such integrated systems. This 'hierarchical analysis' was first developed as an extension to a metabolic control analysis. It builds on the phenomenon that often the communication between signalling, gene expression and metabolic subsystems is almost exclusively via regulatory interactions and not via mass flow interactions. This allows for the treatment of the said subsystems as 'levels' in a hierarchical view of the organisation of the molecular reaction network of cells. Such a hierarchical approach has as a major advantage that levels can be analysed conceptually in isolation of each other (from a local intra-level perspective) and at a later stage integrated via their interactions (from a global inter-level perspective). Hereby, it allows for a modular approach with variable scope. A number of different approaches have been developed for the analysis of hierarchical systems, for example hierarchical control analysis and modular response analysis. The authors, here, review these methods and illustrate the strength of these types of analyses using a core model of a system with gene expression, metabolic and signal transduction levels.

[The information principle in physiology: an analysis from the position of the general theory of functional systems].

PubMed

Sudakov, K V

1995-01-01

Information principle of the organism functional systems creation is formulated in the article. Transformation of organism biological needs on various levels into dominant motivation, behaviour and processes of basis needs satisfaction without loss in information sense is shown. Information role of emotions is analysed. On the base of experimental data is formulated concept of information environment of organism. Specially analysed the information basis of human psychological activity.

Systems-Level Analysis of Innate Immunity

PubMed Central

Zak, Daniel E.; Tam, Vincent C.; Aderem, Alan

2014-01-01

Systems-level analysis of biological processes strives to comprehensively and quantitatively evaluate the interactions between the relevant molecular components over time, thereby enabling development of models that can be employed to ultimately predict behavior. Rapid development in measurement technologies (omics), when combined with the accessible nature of the cellular constituents themselves, is allowing the field of innate immunity to take significant strides toward this lofty goal. In this review, we survey exciting results derived from systems biology analyses of the immune system, ranging from gene regulatory networks to influenza pathogenesis and systems vaccinology. PMID:24655298

Monte Carlo simulations for generic granite repository studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chu, Shaoping; Lee, Joon H; Wang, Yifeng

In a collaborative study between Los Alamos National Laboratory (LANL) and Sandia National Laboratories (SNL) for the DOE-NE Office of Fuel Cycle Technologies Used Fuel Disposition (UFD) Campaign project, we have conducted preliminary system-level analyses to support the development of a long-term strategy for geologic disposal of high-level radioactive waste. A general modeling framework consisting of a near- and a far-field submodel for a granite GDSE was developed. A representative far-field transport model for a generic granite repository was merged with an integrated systems (GoldSim) near-field model. Integrated Monte Carlo model runs with the combined near- and farfield transport modelsmore » were performed, and the parameter sensitivities were evaluated for the combined system. In addition, a sub-set of radionuclides that are potentially important to repository performance were identified and evaluated for a series of model runs. The analyses were conducted with different waste inventory scenarios. Analyses were also conducted for different repository radionuelide release scenarios. While the results to date are for a generic granite repository, the work establishes the method to be used in the future to provide guidance on the development of strategy for long-term disposal of high-level radioactive waste in a granite repository.« less

Back in the USSR: Path Dependence Effects in Student Representation in Russia

ERIC Educational Resources Information Center

Chirikov, Igor; Gruzdev, Ivan

2014-01-01

This paper analyses the current state of student representation in Russia as deeply rooted in the institutional structure of the Soviet higher education system. The study traces the origins of existing institutional arrangements for student representation at the level of university governance and analyses how representation practices have been…

A new Link for Geographic analyses of Inventory Data

Treesearch

David Reed; Kurt Pregitzer; Scott A. Pugh; Patrick D. Miles

2001-01-01

The USDA Forest Service Forest Inventory and Analysis (FIA)data are widely used throughout the United States for analyses of forest status and trends, landscape-level forest composition, and other forest characteristics. A new software product, FIAMODEL, is available for analyzing FIA data within the ArcView? (ESRI, Inc.)geographic information system. The software...

The Impact of British Airways Wind Observations on the Goddard Earth Observing System Analyses and Forecasts

NASA Technical Reports Server (NTRS)

Rukhovets, Leonid; Sienkiewicz, M.; Tenenbaum, J.; Kondratyeva, Y.; Owens, T.; Oztunali, M.; Atlas, Robert (Technical Monitor)

2001-01-01

British Airways flight data recorders can provide valuable meteorological information, but they are not available in real-time on the Global Telecommunication System. Information from the flight recorders was used in the Global Aircraft Data Set (GADS) experiment as independent observations to estimate errors in wind analyses produced by major operational centers. The GADS impact on the Goddard Earth Observing System Data Assimilation System (GEOS DAS) analyses was investigated using GEOS-1 DAS version. Recently, a new Data Assimilation System (fvDAS) has been developed at the Data Assimilation Office, NASA Goddard. Using fvDAS , the, GADS impact on analyses and forecasts was investigated. It was shown the GADS data intensify wind speed analyses of jet streams for some cases. Five-day forecast anomaly correlations and root mean squares were calculated for 300, 500 hPa and SLP for six different areas: Northern and Southern Hemispheres, North America, Europe, Asia, USA These scores were obtained as averages over 21 forecasts from January 1998. Comparisons with scores for control experiments without GADS showed a positive impact of the GADS data on forecasts beyond 2-3 days for all levels at the most areas.

Is Operative Treatment of Achilles Tendon Ruptures Superior to Nonoperative Treatment?

PubMed Central

Erickson, Brandon J.; Mascarenhas, Randy; Saltzman, Bryan M.; Walton, David; Lee, Simon; Cole, Brian J.; Bach, Bernard R.

2015-01-01

Background: Multiple meta-analyses have been published in efforts to determine whether operative or nonoperative treatment of Achilles tendon ruptures affords superior outcomes. Purpose: To perform a systematic review of overlapping meta-analyses comparing operative and nonoperative treatment of Achilles tendon ruptures to determine which meta-analyses provide the highest level of evidence for treatment recommendations. Study Design: Systematic review; Level of evidence, 3. Methods: A systematic review of the literature was performed to identify meta-analyses that fit the study inclusion criteria. Data were extracted from these meta-analyses regarding patient outcomes and reruptures. Meta-analysis quality was assessed using the Oxman-Guyatt and QUOROM (Quality of Reporting of Meta-analyses) systems. The Jadad algorithm was applied to determine the meta-analyses with the highest level of evidence. Results: Nine meta-analyses met the eligibility criteria, with all but 1 study including level 1 evidence. A total of 5842 patients were included. Seven studies found a higher rate of rerupture in the nonoperative group but a higher rate of complications in the operative group. One study found no differences in rerupture or complication rates, and 1 study found surgery decreased rerupture rates only when compared with nonoperative treatment without a functional brace. Three studies also identified an earlier return to work in the operative group. Almost all (8 of 9) of the meta-analyses had Oxman-Guyatt scores >3, indicating no major flaws. Conclusion: Operative treatment of Achilles tendon ruptures decreases rerupture rates but increases the risk for minor complications when compared with nonoperative treatment. Additionally, surgical treatment may allow earlier return to work. PMID:26665055

Applicability of two mobile analysers for mercury in urine in small-scale gold mining areas.

PubMed

Baeuml, Jennifer; Bose-O'Reilly, Stephan; Lettmeier, Beate; Maydl, Alexandra; Messerer, Katalin; Roider, Gabriele; Drasch, Gustav; Siebert, Uwe

2011-12-01

Mercury is still used in developing countries to extract gold from the ore in small-scale gold mining areas. This is a major health hazard for people living in mining areas. The concentration of mercury in urine was analysed in different mining areas in Zimbabwe, Indonesia and Tanzania. First the urine samples were analysed by CV-AAS (cold vapour atomic absorption spectrometry) during the field projects with a mobile mercury analyser (Lumex(®) or Seefelder(®)) and secondly, in a laboratory with a stationary CV-AAS mercury analyser (PerkinElmer(®)). Caused by the different systems (reduction agent either SnCl(2) (Lumex(®) or Seefelder(®))) or NaBH(4) (PerkinElmer(®)), with the mobile analysers only the inorganic mercury was obtained and with the stationary system the total mercury concentration was measured. The aims of the study were whether the results obtained in field with the mobile equipments can be compared with the stationary reference method in the laboratory and allow the application of these mobile analysers in screening studies on concerned populations to select those, who are exposed to critical mercury levels. Overall, the concentrations obtained with the two mobile systems were approximately 25% lower than determined with the stationary system. Nevertheless, both mobile systems seem to be very useful for screening of volunteers in field. Moreover, regional staff may be trained on such analysers to perform screening tests by themselves. Copyright © 2011 Elsevier GmbH. All rights reserved.

Alabama's Education Report Card, 2000: Significant Predictors of Student Achievement at the District and School Level. Research Brief.

ERIC Educational Resources Information Center

Miller-Whitehead, Marie

This paper examines Alabama's State Education Report Card for the year 2000. It identifies predictors for student academic achievement at both the district and school levels for 128 public school systems and 1,272 public schools. Separate analyses were conducted for 61 city and 67 county school systems. The variables included number of students,…

Vocational Education and the Binary Higher Education System in the Netherlands: Higher Education Symbiosis or Vocational Education Dichotomy?

ERIC Educational Resources Information Center

van Houten, Maarten Matheus

2018-01-01

The Netherlands has a binary higher education system in which academic education and higher professional education at EQF levels 5-8 co-exist. There is also secondary vocational education at EQF levels 1 up to 4. In this paper, I analyse policy documents resulting from the Bologna Process and argue that under neo-liberal conditions, higher…

Simulation of the effects of rainfall and groundwater use on historical lake water levels, groundwater levels, and spring flows in central Florida

USGS Publications Warehouse

O'Reilly, Andrew M.; Roehl, Edwin A.; Conrads, Paul; Daamen, Ruby C.; Petkewich, Matthew D.

2014-01-01

The urbanization of central Florida has progressed substantially in recent decades, and the total population in Lake, Orange, Osceola, Polk, and Seminole Counties more than quadrupled from 1960 to 2010. The Floridan aquifer system is the primary source of water for potable, industrial, and agricultural purposes in central Florida. Despite increases in groundwater withdrawals to meet the demand of population growth, recharge derived by infiltration of rainfall in the well-drained karst terrain of central Florida is the largest component of the long-term water balance of the Floridan aquifer system. To complement existing physics-based groundwater flow models, artificial neural networks and other data-mining techniques were used to simulate historical lake water level, groundwater level, and spring flow at sites throughout the area. Historical data were examined using descriptive statistics, cluster analysis, and other exploratory analysis techniques to assess their suitability for more intensive data-mining analysis. Linear trend analyses of meteorological data collected by the National Oceanic and Atmospheric Administration at 21 sites indicate 67 percent of sites exhibited upward trends in air temperature over at least a 45-year period of record, whereas 76 percent exhibited downward trends in rainfall over at least a 95-year period of record. Likewise, linear trend analyses of hydrologic response data, which have varied periods of record ranging in length from 10 to 79 years, indicate that water levels in lakes (307 sites) were about evenly split between upward and downward trends, whereas water levels in 69 percent of wells (out of 455 sites) and flows in 68 percent of springs (out of 19 sites) exhibited downward trends. Total groundwater use in the study area increased from about 250 million gallons per day (Mgal/d) in 1958 to about 590 Mgal/d in 1980 and remained relatively stable from 1981 to 2008, with a minimum of 559 Mgal/d in 1994 and a maximum of 773 Mgal/d in 2000. The change in groundwater-use trend in the early 1980s and the following period of relatively slight trend is attributable to the concomitant effects of increasing public-supply withdrawals and decreasing use of water by the phosphate industry and agriculture. On the basis of available historical data and exploratory analyses, empirical lake water-level, groundwater-level, and spring-flow models were developed for 22 lakes, 23 wells, and 6 springs. Input time series consisting of various frequencies and frequency-band components of daily rainfall (1942 to 2008) and monthly total groundwater use (1957 to 2008) resulted in hybrid signal-decomposition artificial neural network models. The final models explained much of the variability in observed hydrologic data, with 43 of the 51 sites having coefficients of determination exceeding 0.6, and the models matched the magnitude of the observed data reasonably well, such that models for 32 of the 51 sites had root-mean-square errors less than 10 percent of the measured range of the data. The Central Florida Artificial Neural Network Decision Support System was developed to integrate historical databases and the 102 site-specific artificial neural network models, model controls, and model output into a spreadsheet application with a graphical user interface that allows the user to simulate scenarios of interest. Overall, the data-mining analyses indicate that the Floridan aquifer system in central Florida is a highly conductive, dynamic, open system that is strongly influenced by external forcing. The most important external forcing appears to be rainfall, which explains much of the multiyear cyclic variability and long-term downward trends observed in lake water levels, groundwater levels, and spring flows. For most sites, groundwater use explains less of the observed variability in water levels and flows than rainfall. Relative groundwater-use impacts are greater during droughts, however, and long-term trends in water levels and flows were identified that are consistent with historical groundwater-use patterns. The sensitivity of the hydrologic system to rainfall is expected, owing to the well-drained karst terrain and relatively thin confinement of the Floridan aquifer system in much of central Florida. These characteristics facilitate the relatively rapid transmission of infiltrating water from rainfall to the water table and contribute to downward leakage of water to the Floridan aquifer system. The areally distributed nature of rainfall, as opposed to the site-specific nature of groundwater use, and the generally high transmissivity and low storativity properties of the semiconfined Floridan aquifer system contribute to the prevalence of water-level and flow patterns that mimic rainfall patterns. In general, the data-mining analyses demonstrate that the hydrologic system in central Florida is affected by groundwater use differently during wet periods, when little or no system storage is available (high water levels), compared to dry periods, when there is excess system storage (low water levels). Thus, by driving the overall behavior of the system, rainfall indirectly influences the degree to which groundwater use will effect persistent trends in water levels and flows, with groundwater-use impacts more prevalent during periods of low water levels and spring flows caused by low rainfall and less prevalent during periods of high water levels and spring flows caused by high rainfall. Differences in the magnitudes of rainfall and groundwater use during wet and dry periods also are important determinants of hydrologic response. An important implication of the data-mining analyses is that rainfall variability at subannual to multidecadal timescales must be considered in combination with groundwater use to provide robust system-response predictions that enhance sustainable resource management in an open karst aquifer system. The data-driven approach was limited, however, by the confounding effects of correlation between rainfall and groundwater use, the quality and completeness of the historical databases, and the spatial variations in groundwater use. The data-mining analyses indicate that available historical data when used alone do not contain sufficient information to definitively quantify the related individual effects of rainfall and groundwater use on hydrologic response. The knowledge gained from data-driven modeling and the results from physics-based modeling, when compared and used in combination, can yield a more comprehensive assessment and a more robust understanding of the hydrologic system than either of the approaches used separately.

Cytokines in relation to autoantibodies before onset of symptoms for systemic lupus erythematosus.

PubMed

Eriksson, C; Rantapää-Dahlqvist, S

2014-06-01

A number of cytokines and chemokines were analysed and related to autoantibodies in blood samples pre-dating the onset of symptoms of systemic lupus erythematosus. Thirty-five patients with systemic lupus erythematosus (American College of Rheumatology criteria) were identified as having donated blood samples, prior to symptom onset, to the Biobank of northern Sweden. Altogether, 140 age- and sex-matched controls were also identified. The concentrations of interferon-α, interleukin-4, interleukin-9, interleukin-10, interferon inducible protein-10 and monocyte chemotactic protein-1 were analysed using multiplex technology and related to autoantibodies (ANA, ENA, anti-dsDNA and anti-histone antibodies) analysed from the same blood sample. The interferon-γ inducible protein-10 levels were higher in the pre-symptomatic individuals than in controls (p < 0.05) and correlated with interferon-α (p < 0.01). The interferon-γ inducible protein-10 and interferon-α concentrations were significantly increased in individuals positive for autoantibodies: interferon-γ inducible protein-10 for ANA; anti-SSA/Ro and anti-Jo-1 antibodies; interferon-α with anti-SSB/La antibodies. The levels of interleukin-10, interferon-γ inducible protein-10 and monocyte chemotactic protein-1 increased significantly from the pre-symptomatic individuals to after onset of systemic lupus erythematosus. An increased concentration of interferon-γ inducible protein-10 pre-dated the onset of systemic lupus erythematosus and was related to autoantibodies before the onset of disease. The levels of interferon-γ inducible protein-10 and interferon-α were correlated. These findings support the proposal that the interferon system is important early in the pathogenesis of systemic lupus erythematosus and autoantibody formation. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Tradeoffs in the design of a system for high level language interpretation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Osorio, F.C.C.; Patt, Y.N.

The problem of designing a system for high-level language interpretation (HLLI) is considered. First, a model of the design process is presented where several styles of design, e.g. turing machine interpretation, CISC architecture interpretation and RISC architecture interpretation are treated uniformly. Second, the most significant characteristics of HLLI are analysed in the context of different design styles, and some guidelines are presented on how to identify the most suitable design style for a given high-level language problem. 12 references.

The model of the optical-electronic control system of vehicles location at level crossing

NASA Astrophysics Data System (ADS)

Verezhinskaia, Ekaterina A.; Gorbachev, Aleksei A.; Maruev, Ivan A.; Shavrygina, Margarita A.

2016-04-01

Level crossing - one of the most dangerous sections of the road network, where railway line crosses motor road at the same level. The collision of trains with vehicles at a level crossing is a serious type of road traffic accidents. The purpose of this research is to develop complex optical electronic control system of vehicles location in the dangerous zone of level crossing. The system consists of registration blocks (including photodetector, lens, infrared emitting diode), determinant devices and camera installed within the boundaries of level crossing. The system performs detection of objects (vehicles) by analysing the time of the object movement opposite to the registration block and level of the reflected signal from the object. The paper presents theoretical description and experimental research of main principles of the system operation. Experimental research of the system model with selected optical-electronic components have confirmed the possibility of metal objects detection at the required distance (0.5 - 2 m) with different values of background illuminance.

[Structural analysis of the functional status of the brain as affected by bemethyl using pattern recognition theory].

PubMed

Bobkov, Iu G; Machula, A I; Morozov, Iu I; Dvalishvili, E G

1987-11-01

Evoked visual potentials in associated, parietal and second somatosensory zones of the neocortex were analysed in trained cats using implanted electrodes. The influence of bemethyl on the structure of behavioral reactions was analysed using theoretical methods of perceptual images, particularly the method of cluster analysis. Bemethyl was shown to increase the level of interaction between the functional elements of the system, leading to a more stable resolution of problems facing the system, as compared to the initial state.

Early Versus Delayed Motion After Rotator Cuff Repair: A Systematic Review of Overlapping Meta-analyses.

PubMed

Houck, Darby A; Kraeutler, Matthew J; Schuette, Hayden B; McCarty, Eric C; Bravman, Jonathan T

2017-10-01

Previous meta-analyses have been conducted to compare outcomes of early versus delayed motion after rotator cuff repair. To conduct a systematic review of overlapping meta-analyses comparing early versus delayed motion rehabilitation protocols after rotator cuff repair to determine which meta-analyses provide the best available evidence. Systematic review. A systematic review was performed by searching PubMed and Cochrane Library databases. Search terms included "rotator cuff repair," "early passive motion," "immobilization," "rehabilitation protocol," and "meta-analysis." Results were reviewed to determine study eligibility. Patient outcomes and structural healing were extracted from these meta-analyses. Meta-analysis quality was assessed using the Oxman-Guyatt and Quality of Reporting of Meta-analyses (QUOROM) systems. The Jadad decision algorithm was then used to determine which meta-analyses provided the best level of evidence. Seven meta-analyses containing a total of 5896 patients met the eligibility criteria (1 Level I evidence, 4 Level II evidence, 2 Level III evidence). None of these meta-analyses found immobilization to be superior to early motion; however, most studies suggested that early motion would increase range of motion (ROM), thereby reducing time of recovery. Three of these studies suggested that tear size contributed to the choice of rehabilitation to ensure proper healing of the shoulder. A study by Chan et al in 2014 received the highest QUOROM and Oxman-Guyatt scores, and therefore this meta-analysis appeared to have the highest level of evidence. Additionally, a study by Riboh and Garrigues in 2014 was selected as the highest quality study in this systematic review according to the Jadad decision algorithm. The current, best available evidence suggests that early motion improves ROM after rotator cuff repair but increases the risk of rotator cuff retear. Lower quality meta-analyses indicate that tear size may provide a better strategy in determining the correct rehabilitation protocol.

Space Tug avionics definition study. Volume 4: Supporting trade studies and analyses

NASA Technical Reports Server (NTRS)

1975-01-01

Analyses and trade studies were performed for the evaluation of the most desirable solutions to space tug subsystem requirements. These were accomplished at system, subsystem, and at component levels. The criteria, the candidate options evaluated, the selection process, and the recommended solutions that have been integrated together in the configuration descriptions are reported.

FIAMODEL : a new link for geographic analyses of inventory data

Treesearch

David Reed; Kurt Pregitzer; Scott A. Pugh; Patrick Miles

2001-01-01

The USDA Forest Service Forest Inventory and Analysis (FIA) data are widely used throughtout the United States for analyses of forest status and trends, landscape-level forest composition, and other forest characteristics. A new software product, FIAMODEL, is available for analyzing FIA data within the ArcView (ESRI,Inc.) geographic information system. The software...

Control of a Vanadium Redox Battery and supercapacitor using a Three-Level Neutral Point Clamped converter

NASA Astrophysics Data System (ADS)

Etxeberria, A.; Vechiu, I.; Baudoin, S.; Camblong, H.; Kreckelbergh, S.

2014-02-01

The increasing use of distributed generators, which are mainly based on renewable sources, can create several issues in the operation of the electric grid. The microgrid is being analysed as a solution to the integration in the grid of the renewable sources at a high penetration level in a controlled way. The storage systems play a vital role in order to keep the energy and power balance of the microgrid. Due to the technical limitations of the currently available storage systems, it is necessary to use more than one storage technology to satisfy the requirements of the microgrid application. This work validates in simulations and experimentally the use of a Three-Level Neutral Point Clamped converter to control the power flow of a hybrid storage system formed by a SuperCapacitor and a Vanadium Redox Battery. The operation of the system is validated in two case studies in the experimental platform installed in ESTIA. The experimental results prove the validity of the proposed system as well as the designed control algorithm. The good agreement among experimental and simulation results also validates the simulation model, that can therefore be used to analyse the operation of the system in different case studies.

Atmospheric Mining in the Outer Solar System: Outer Planet Orbital Transfer and Lander Analyses

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

2016-01-01

Atmospheric mining in the outer solar system has been investigated as a means of fuel production for high energy propulsion and power. Fusion fuels such as Helium 3 (3He) and deuterium can be wrested from the atmospheres of Uranus and Neptune and either returned to Earth or used in-situ for energy production. Helium 3 and deuterium were the primary gases of interest with hydrogen being the primary propellant for nuclear thermal solid core and gas core rocket-based atmospheric flight. A series of analyses were undertaken to investigate resource capturing aspects of atmospheric mining in the outer solar system. This included the gas capturing rate, storage options, and different methods of direct use of the captured gases. While capturing 3He, large amounts of hydrogen and 4He are produced. Analyses of orbital transfer vehicles (OTVs), landers, and the issues with in-situ resource utilization (ISRU) mining factories are included. Preliminary observations are presented on near-optimal selections of moon base orbital locations, OTV power levels, and OTV and lander rendezvous points. For analyses of round trip OTV flights from Uranus to Miranda or Titania, a 10-Megawatt electric (MWe) OTV power level and a 200-metric ton (MT) lander payload were selected based on a relative short OTV trip time and minimization of the number of lander flights. A similar optimum power level is suggested for OTVs flying from low orbit around Neptune to Thalassa or Triton. Several moon base sites at Uranus and Neptune and the OTV requirements to support them are also addressed.

Atmospheric Mining in the Outer Solar System: Outer Planet Orbital Transfer and Lander Analyses

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

2016-01-01

Atmospheric mining in the outer solar system has been investigated as a means of fuel production for high energy propulsion and power. Fusion fuels such as Helium 3 (3He) and deuterium can be wrested from the atmospheres of Uranus and Neptune and either returned to Earth or used in-situ for energy production. Helium 3 and deuterium were the primary gases of interest with hydrogen being the primary propellant for nuclear thermal solid core and gas core rocket-based atmospheric flight. A series of analyses were undertaken to investigate resource capturing aspects of atmospheric mining in the outer solar system. This included the gas capturing rate, storage options, and different methods of direct use of the captured gases. While capturing 3He, large amounts of hydrogen and 4He are produced. Analyses of orbital transfer vehicles (OTVs), landers, and the issues with in-situ resource utilization (ISRU) mining factories are included. Preliminary observations are presented on near-optimal selections of moon base orbital locations, OTV power levels, and OTV and lander rendezvous points. For analyses of round trip OTV flights from Uranus to Miranda or Titania, a 10- Megawatt electric (MWe) OTV power level and a 200 metricton (MT) lander payload were selected based on a relative short OTV trip time and minimization of the number of lander flights. A similar optimum power level is suggested for OTVs flying from low orbit around Neptune to Thalassa or Triton. Several moon base sites at Uranus and Neptune and the OTV requirements to support them are also addressed.

Turbopump Design and Analysis Approach for Nuclear Thermal Rockets

NASA Technical Reports Server (NTRS)

Chen, Shu-cheng S.; Veres, Joseph P.; Fittje, James E.

2006-01-01

A rocket propulsion system, whether it is a chemical rocket or a nuclear thermal rocket, is fairly complex in detail but rather simple in principle. Among all the interacting parts, three components stand out: they are pumps and turbines (turbopumps), and the thrust chamber. To obtain an understanding of the overall rocket propulsion system characteristics, one starts from analyzing the interactions among these three components. It is therefore of utmost importance to be able to satisfactorily characterize the turbopump, level by level, at all phases of a vehicle design cycle. Here at NASA Glenn Research Center, as the starting phase of a rocket engine design, specifically a Nuclear Thermal Rocket Engine design, we adopted the approach of using a high level system cycle analysis code (NESS) to obtain an initial analysis of the operational characteristics of a turbopump required in the propulsion system. A set of turbopump design codes (PumpDes and TurbDes) were then executed to obtain sizing and performance characteristics of the turbopump that were consistent with the mission requirements. A set of turbopump analyses codes (PUMPA and TURBA) were applied to obtain the full performance map for each of the turbopump components; a two dimensional layout of the turbopump based on these mean line analyses was also generated. Adequacy of the turbopump conceptual design will later be determined by further analyses and evaluation. In this paper, descriptions and discussions of the aforementioned approach are provided and future outlooks are discussed.

Impact of multisectoral health determinants on child mortality 1980-2010: An analysis by country baseline mortality.

PubMed

Cohen, Robert L; Murray, John; Jack, Susan; Arscott-Mills, Sharon; Verardi, Vincenzo

2017-01-01

Some health determinants require relatively stronger health system capacity and socioeconomic development than others to impact child mortality. Few quantitative analyses have analyzed how the impact of health determinants varies by mortality level. 149 low- and middle-income countries were stratified into high, moderate, low, and very low baseline levels of child mortality in 1990. Data for 52 health determinants were collected for these countries for 1980-2010. To quantify how changes in health determinants were associated with mortality decline, univariable and multivariable regression models were constructed. An advanced statistical technique that is new for child mortality analyses-MM-estimation with first differences and country clustering-controlled for outliers, fixed effects, and variation across decades. Some health determinants (immunizations, education) were consistently associated with child mortality reduction across all mortality levels. Others (staff availability, skilled birth attendance, fertility, water and sanitation) were associated with child mortality reduction mainly in low or very low mortality settings. The findings indicate that the impact of some health determinants on child mortality was only apparent with stronger health systems, public infrastructure and levels of socioeconomic development, whereas the impact of other determinants was apparent at all stages of development. Multisectoral progress was essential to mortality reduction at all baseline mortality levels. Policy-makers can use such analyses to direct investments in health and non-health sectors and to set five-year child mortality targets appropriate for their baseline mortality levels and local context.

Toward an understanding of immune cell sociology: real-time monitoring of cytokine secretion at the single-cell level.

PubMed

Shirasaki, Yoshitaka; Yamagishi, Mai; Shimura, Nanako; Hijikata, Atsushi; Ohara, Osamu

2013-01-01

The immune system is a very complex and dynamic cellular system, and its intricacies are considered akin to those of human society. Disturbance of homeostasis of the immune system results in various types of diseases; therefore, the homeostatic mechanism of the immune system has long been a subject of great interest in biology, and a lot of information has been accumulated at the cellular and the molecular levels. However, the sociological aspects of the immune system remain too abstract to address because of its high complexity, which mainly originates from a large number and variety of cell-cell interactions. As long-range interactions mediated by cytokines play a key role in the homeostasis of the immune system, cytokine secretion analyses, ranging from analyses of the micro level of individual cells to the macro level of a bulk of cell ensembles, provide us with a solid basis of a sociological viewpoint of the immune system. In this review, as the first step toward a comprehensive understanding of immune cell sociology, cytokine secretion of immune cells is surveyed with a special emphasis on the single-cell level, which has been overlooked but should serve as a basis of immune cell sociology. Now that it has become evident that large cell-to-cell variations in cytokine secretion exist at the single-cell level, we face a tricky yet interesting question: How is homeostasis maintained when the system is composed of intrinsically noisy agents? In this context, we discuss how the heterogeneity of cytokine secretion at the single-cell level affects our view of immune cell sociology. While the apparent inconsistency between homeostasis and cell-to-cell heterogeneity is difficult to address by a conventional reductive approach, comparison and integration of single-cell data with macroscopic data will offer us a new direction for the comprehensive understanding of immune cell sociology. Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.

Use of Spatial Epidemiology and Hot Spot Analysis to Target Women Eligible for Prenatal Women, Infants, and Children Services

PubMed Central

Krawczyk, Christopher; Gradziel, Pat; Geraghty, Estella M.

2014-01-01

Objectives. We used a geographic information system and cluster analyses to determine locations in need of enhanced Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) Program services. Methods. We linked documented births in the 2010 California Birth Statistical Master File with the 2010 data from the WIC Integrated Statewide Information System. Analyses focused on the density of pregnant women who were eligible for but not receiving WIC services in California’s 7049 census tracts. We used incremental spatial autocorrelation and hot spot analyses to identify clusters of WIC-eligible nonparticipants. Results. We detected clusters of census tracts with higher-than-expected densities, compared with the state mean density of WIC-eligible nonparticipants, in 21 of 58 (36.2%) California counties (P < .05). In subsequent county-level analyses, we located neighborhood-level clusters of higher-than-expected densities of eligible nonparticipants in Sacramento, San Francisco, Fresno, and Los Angeles Counties (P < .05). Conclusions. Hot spot analyses provided a rigorous and objective approach to determine the locations of statistically significant clusters of WIC-eligible nonparticipants. Results helped inform WIC program and funding decisions, including the opening of new WIC centers, and offered a novel approach for targeting public health services. PMID:24354821

The Conduct System and Its Infuence on Student Learning

ERIC Educational Resources Information Center

Stimpson, Matthew T.; Janosik, Steven M.

2015-01-01

In this study, 7 items were used to define a composite variable that measures the perceived effectiveness of student conduct systems. Multivariate Analysis of Variance (MANOVA) was used to test the relationship between perceived level of system effectiveness and self-reported student learning. In the analyses, 49% of the variance in reported…

Inclusive Education in Sweden? A Critical Analysis

ERIC Educational Resources Information Center

Goransson, Kerstin; Nilholm, Claes; Karlsson, Kristina

2011-01-01

When it comes to pupils in need of special support and pupils with disabilities, Sweden's compulsory school system is sometimes considered a one-track system. This article analyses and critically discusses current policy and practices at various levels of Sweden's compulsory school system for these pupils. The analysis traces three themes at the…

Public policy for solar heating and cooling

NASA Technical Reports Server (NTRS)

Hirshberg, A. S.

1976-01-01

Recent analyses indicated that solar heating and cooling systems for residential buildings are nearly economically competitive with conventional fossil fuel or electric systems, the former having higher initial cost but a lower operating cost than the latter. The paper examines obstacles to the widespread acceptance and use of solar space conditioning systems and explores some general policies which could help to overcome them. The discussion covers such institutional barriers limiting the adoption of solar technologies as existing building codes, financing constraints, and organizational structure of the building industry. The potential impact of financial incentives is analyzed. It is noted that a tax incentive of 25% could speed the use of solar energy by 7 to 8 years and produce an 8% reduction in fossil fuel use by 1990. A preliminary incentive package which could be helpful in promoting solar energy both at federal and state levels is proposed, and the necessary incentive level is analysed.

Small Aircraft Transportation System Simulation Analysis of the HVO and ERO Concepts

NASA Technical Reports Server (NTRS)

Millsaps, Gary D.; Yackovetsky, Robert E. (Technical Monitor)

2003-01-01

It is acknowledged that the aviation and aerospace industries are primary forces influencing the industrial development and economic well being of the United States and many countries around the world. For decades the US national air transportation system has been the model of success - safely and efficiently moving people, cargo, goods and services and generating countless benefits throughout the global community; however, the finite nature of the system and many of its components is becoming apparent. Without measurable increases in the capacity of the national air transportation system, delays and service delivery failures will eventually become intolerable. Although the recent economic slowdown has lowered immediate travel demands, that trend is reversing and cargo movement remains high. Research data indicates a conservative 2.5-3.0% annual increase in aircraft operations nationwide through 2017. Such growth will place additional strains upon a system already experiencing capacity constraints. The stakeholders of the system will continue to endure ever-increasing delays and abide lesser levels of service to many lower population density areas of the country unless more efficient uses of existing and new transportation resources are implemented. NASA s Small Aircraft Transportation System program (SATS) is one of several technologies under development that are aimed at using such resources more effectively. As part of this development effort, this report is the first in a series outlining the findings and recommendations resulting from a comprehensive program of multi-level analyses and system engineering efforts undertaken by NASA Langley Research Center s Systems Analysis Branch (SAB). These efforts are guided by a commitment to provide systems-level analysis support for the SATS program. Subsequent efforts will build upon this early work to produce additional analyses and benefits studies needed to provide the technical and economic basis for national investment and policy decisions related to further development and potential deployment of a small aircraft transportation system. This report primarily serves two purposes. First, it presents results attained from an initial evaluation and analysis of the Higher Volume Operations (HVO) and EnRoute Operations (ERO) concepts - both designated operational capabilities within the SATS Program s Concept of Operations (CONOPS) document. It further outlines areas of the concepts that would benefit from follow-on analyses and system engineering efforts. It is intended that these processes will aid continued maturation of the concepts and promote additional studies of their effects and influences in combination with other designated CONOPS currently under development. In essence, it establishes a baseline of data upon which subsequent analyses and studies can be built and identifies performance characteristics the concept must exhibit in order to provide, at minimum, levels of safety and usage equal to or better than the current system.

Contrasting patterns of X/Y polymorphism distinguish Carica papaya from other sex chromosome systems.

PubMed

Weingartner, Laura A; Moore, Richard C

2012-12-01

The sex chromosomes of the tropical crop papaya (Carica papaya) are evolutionarily young and consequently allow for the examination of evolutionary mechanisms that drive early sex chromosome divergence. We conducted a molecular population genetic analysis of four X/Y gene pairs from a collection of 45 wild papaya accessions. These population genetic analyses reveal striking differences in the patterns of polymorphism between the X and Y chromosomes that distinguish them from other sex chromosome systems. In most sex chromosome systems, the Y chromosome displays significantly reduced polymorphism levels, whereas the X chromosome maintains a level of polymorphism that is comparable to autosomal loci. However, the four papaya sex-linked loci that we examined display diversity patterns that are opposite this trend: the papaya X alleles exhibit significantly reduced polymorphism levels, whereas the papaya Y alleles maintain greater than expected levels of diversity. Our analyses suggest that selective sweeps in the regions of the X have contributed to this pattern while also revealing geographically restricted haplogroups on the Y. We discuss the possible role sexual selection and/or genomic conflict have played in shaping the contrasting patterns of polymorphism found for the papaya X and Y chromosomes.

Critical incident reporting and learning.

PubMed

Mahajan, R P

2010-07-01

The success of incident reporting in improving safety, although obvious in aviation and other high-risk industries, is yet to be seen in health-care systems. An incident reporting system which would improve patient safety would allow front-end clinicians to have easy access for reporting an incident with an understanding that their report will be handled in a non-punitive manner, and that it will lead to enhanced learning regarding the causation of the incident and systemic changes which will prevent it from recurring. At present, significant problems remain with local and national incident reporting systems. These include fear of punitive action, poor safety culture in an organization, lack of understanding among clinicians about what should be reported, lack of awareness of how the reported incidents will be analysed, and how will the reports ultimately lead to changes which will improve patient safety. In particular, lack of systematic analysis of the reports and feedback directly to the clinicians are seen as major barriers to clinical engagement. In this review, robust systematic methodology of analysing incidents is discussed. This methodology is based on human factors model, and the learning paradigm which emphasizes significant shift from traditional judicial approach to understanding how 'latent errors' may play a role in a chain of events which can set up an 'active error' to occur. Feedback directly to the clinicians is extremely important for keeping them 'in the loop' for their continued engagement, and it should target different levels of analyses. In addition to high-level information on the types of incidents, the feedback should incorporate results of the analyses of active and latent factors. Finally, it should inform what actions, and at what level/stage, have been taken in response to the reported incidents. For this, local and national systems will be required to work in close cooperation, so that the lessons can be learnt and actions taken within an organization, and across organizations. In the UK, a recently introduced speciality-specific incident reporting system for anaesthesia aims to incorporate the elements of successful reporting system, as presented in this review, to achieve enhanced clinical engagement and improved patient safety.

Operationalizing System Importance Measures for Assessing System of System Resilience

NASA Astrophysics Data System (ADS)

Chandrahasa, Rakshit

In recent times, there has been a shift in focus from component level to system level analysis and an increasing effort to understand and design resilience into the system. Several efforts have been carried out in creating metrics to analyse resilience. Understanding and implementing system resilience in complex System of Systems will help us in building safer and resilient systems. System Importance Measures (SIMs) was formulated to analyse System of System resilience and help in designing a resilient SoS. Here, we operationalize these System Importance Measures for designing a resilient SoS. We first look at the existing methodology to improve the visual representation of system resilience and its usability. We demonstrate this using our first case study with a Naval warfare SoS. We incorporate probability into the SIM formulation. We expand the existing SIMs to quantify the effects of disruptions and mitigation likelihoods. We built a second case study based on Air transportation networks and demonstrated our expanded metrics in both the case studies. SIM based analysis of SoS resilience provides us with two different analysis of resilience, with and without probability. Having an outlook on how the resilience changes with a probability of disruptions can aid the designer making informed choices on design changes and help in creating a resilient SoS.

Schoolyard physical activity in 14-year-old adolescents assessed by mobile GPS and heart rate monitoring analysed by GIS.

PubMed

Fjørtoft, Ingunn; Löfman, Owe; Halvorsen Thorén, Kine

2010-11-01

Environmental settings seem to influence the activity patterns of children in neighbourhoods and schoolyards, the latter being an important arena to promote physical activity (PA) in school children. New technology has made it possible to describe free-living PA in interaction with the environment. This study focused on how schoolyard environments influenced the activity patterns and intensity levels in 14-year-old children and whether PA levels in adolescents complied with official recommendations. Another objective was to introduce methodology of using a mobile global positioning system (GPS) device with synchronous heart rate (HR) recordings as a proxy for PA level and a geographical information system (GIS) for spatial analyses. The sample constituted of 81 children (aged 14 years) from two schools. Movement patterns and activity levels were recorded during lunch break applying a GPS Garmin Forerunner 305 with combined HR monitoring and analysed in a GIS by an overlaid grid and kriging interpolation. Spatial data from GPS recordings showed particular movement patterns in the schoolyards. Low activity levels (mean HR < 120 bpm) dominated in both schools with no gender differences. Activities located to a handball goal area showed the highest monitored HR (>160 bpm) with higher intensity in girls than in boys. Movement patterns and PA generated in GIS for visualisation and analysis enabled direct and realistic description of utilising of schoolyard facilities and activity levels. Linking GPS data and PA levels to spatial structures made it possible to visualise the environmental interaction with PA and which environments promoted low or high PA.

High-resolution monitoring of marine protists based on an observation strategy integrating automated on-board filtration and molecular analyses

NASA Astrophysics Data System (ADS)

Metfies, Katja; Schroeder, Friedhelm; Hessel, Johanna; Wollschläger, Jochen; Micheller, Sebastian; Wolf, Christian; Kilias, Estelle; Sprong, Pim; Neuhaus, Stefan; Frickenhaus, Stephan; Petersen, Wilhelm

2016-11-01

Information on recent biomass distribution and biogeography of photosynthetic marine protists with adequate temporal and spatial resolution is urgently needed to better understand the consequences of environmental change for marine ecosystems. Here we introduce and review a molecular-based observation strategy for high-resolution assessment of these protists in space and time. It is the result of extensive technology developments, adaptations and evaluations which are documented in a number of different publications, and the results of the recently completed field testing which are introduced in this paper. The observation strategy is organized at four different levels. At level 1, samples are collected at high spatiotemporal resolution using the remotely controlled automated filtration system AUTOFIM. Resulting samples can either be preserved for later laboratory analyses, or directly subjected to molecular surveillance of key species aboard the ship via an automated biosensor system or quantitative polymerase chain reaction (level 2). Preserved samples are analyzed at the next observational levels in the laboratory (levels 3 and 4). At level 3 this involves molecular fingerprinting methods for a quick and reliable overview of differences in protist community composition. Finally, selected samples can be used to generate a detailed analysis of taxonomic protist composition via the latest next generation sequencing technology (NGS) at level 4. An overall integrated dataset of the results based on the different analyses provides comprehensive information on the diversity and biogeography of protists, including all related size classes. At the same time the cost of the observation is optimized with respect to analysis effort and time.

Estimating historical groundwater levels based on relations with hydrologic and meteorological variables in the U.S. glacial aquifer system

NASA Astrophysics Data System (ADS)

Dudley, R. W.; Hodgkins, G. A.; Nielsen, M. G.; Qi, S. L.

2018-07-01

A number of previous studies have examined relations between groundwater levels and hydrologic and meteorological variables over parts of the glacial aquifer system, but systematic analyses across the entire U.S. glacial aquifer system are lacking. We tested correlations between monthly groundwater levels measured at 1043 wells in the U.S. glacial aquifer system considered to be minimally influenced by human disturbance and selected hydrologic and meteorological variables with the goal of extending historical groundwater records where there were strong correlations. Groundwater levels in the East region correlated most strongly with short-term (1 and 3 month) averages of hydrologic and meteorological variables, while those in the Central and West Central regions yielded stronger correlations with hydrologic and meteorological variables averaged over longer time intervals (6-12 months). Variables strongly correlated with high and low annual groundwater levels were identified as candidate records for use in statistical linear models as a means to fill in and extend historical high and low groundwater levels respectively. Overall, 37.4% of study wells meeting data criteria had successful models for high and (or) low groundwater levels; these wells shared characteristics of relatively higher local precipitation, higher local land-surface slope, lower amounts of clay within the surficial sediments, and higher base-flow index. Streamflow and base flow served as explanatory variables in about two thirds of both high- and low-groundwater-level models in all three regions, and generally yielded more and better models compared to precipitation and Palmer Drought Severity Index. The use of variables such as streamflow with substantially longer and more complete records than those of groundwater wells provide a means for placing contemporary groundwater levels in a longer historical context and can support site-specific analyses such as groundwater modeling.

An N+3 Technology Level Reference Propulsion System

NASA Technical Reports Server (NTRS)

Jones, Scott M.; Haller, William J.; Tong, Michael To-Hing

2017-01-01

An N+3 technology level engine, suitable as a propulsion system for an advanced single-aisle transport, was developed as a reference cycle for use in technology assessment and decision-making efforts. This reference engine serves three main purposes: it provides thermodynamic quantities at each major engine station, it provides overall propulsion system performance data for vehicle designers to use in their analyses, and it can be used for comparison against other proposed N+3 technology-level propulsion systems on an equal basis. This reference cycle is meant to represent the expected capability of gas turbine engines in the N+3 timeframe given reasonable extrapolations of technology improvements and the ability to take full advantage of those improvements.

Growing water scarcity in agriculture: future challenge to global water security.

PubMed

Falkenmark, Malin

2013-11-13

As water is an essential component of the planetary life support system, water deficiency constitutes an insecurity that has to be overcome in the process of socio-economic development. The paper analyses the origin and appearance of blue as well as green water scarcity on different scales and with particular focus on risks to food production and water supply for municipalities and industry. It analyses water scarcity originating from both climatic phenomena and water partitioning disturbances on different scales: crop field, country level and the global circulation system. The implications by 2050 of water scarcity in terms of potential country-level water deficits for food self-reliance are analysed, and the compensating dependence on trade in virtual water for almost half the world population is noted. Planetary-scale conditions for sustainability of the global water circulation system are discussed in terms of a recently proposed Planetary Freshwater Boundary, and the consumptive water use reserve left to be shared between water requirements for global food production, fuelwood production and carbon sequestration is discussed. Finally, the importance of a paradigm shift in the further conceptual development of water security is stressed, so that adequate attention is paid to water's fundamental role in both natural and socio-economic systems.

A Top Level Analysis of Training Management Functions.

ERIC Educational Resources Information Center

Ackerson, Jack

1995-01-01

Discusses how to conduct a top-level analysis of training management functions to identify problems within a training system resulting from rapid growth, the acquisition of new departments, or mergers. The data gathering process and analyses are explained, training management functions and activities are described, and root causes and solutions…

Integrating urbanization into landscape-level ecological assessments.

Treesearch

Jeffrey D. Kline; Alissa Moses; Ralph J. Alig

2001-01-01

Economists and ecologists are often asked to collaborate on landscape-level analyses designed to jointly assess economic and ecological conditions resulting from environmental policy scenarios. This trend toward multidisciplinary projects, coupled with the growing use of geographic information systems, has led to the development policy scenarios. This trend toward...

Investigation of aquifer-system compaction in the Hueco basin, El Paso, Texas, USA

USGS Publications Warehouse

Heywood, Charles

1995-01-01

The Pleistocene geologic history of the Rio Grande valley in the Hueco basin included a cycle of sediment erosion and re-aggradation, resulting in unconformable stratification of sediment of contrasting compressibility and stress history. Since the 1950s large groundwater withdrawals have resulted in significant water-level declines and associated land subsidence. Knowledge of the magnitude and variation of specific storage is needed for developing predictive models of subsidence and groundwater flow simulations. Analyses of piezometric and extensometric data in the form of stress-strain diagrams from a 16 month period yield in situ measurements of aquifer-system compressibility across two discrete aquifer intervals. The linear elastic behaviour of the deeper interval indicates over-consolidation of basin deposits, probably resulting from deeper burial depth before the middle Pleistocene. By contrast, the shallow aquifer system displays an inelastic component, suggesting pre-consolidation stress not significantly greater than current effective stress levels for a sequence of late Pleistocene clay. Harmonic analyses of the piezometric response to earth tides in two water-level piezometers provide an independent estimate of specific storage of aquifer sands.

Genetic variations in the serotonergic system contribute to amygdala volume in humans.

PubMed

Li, Jin; Chen, Chunhui; Wu, Karen; Zhang, Mingxia; Zhu, Bi; Chen, Chuansheng; Moyzis, Robert K; Dong, Qi

2015-01-01

The amygdala plays a critical role in emotion processing and psychiatric disorders associated with emotion dysfunction. Accumulating evidence suggests that amygdala structure is modulated by serotonin-related genes. However, there is a gap between the small contributions of single loci (less than 1%) and the reported 63-65% heritability of amygdala structure. To understand the "missing heritability," we systematically explored the contribution of serotonin genes on amygdala structure at the gene set level. The present study of 417 healthy Chinese volunteers examined 129 representative polymorphisms in genes from multiple biological mechanisms in the regulation of serotonin neurotransmission. A system-level approach using multiple regression analyses identified that nine SNPs collectively accounted for approximately 8% of the variance in amygdala volume. Permutation analyses showed that the probability of obtaining these findings by chance was low (p = 0.043, permuted for 1000 times). Findings showed that serotonin genes contribute moderately to individual differences in amygdala volume in a healthy Chinese sample. These results indicate that the system-level approach can help us to understand the genetic basis of a complex trait such as amygdala structure.

Barriers to healthcare coordination in market-based and decentralized public health systems: a qualitative study in healthcare networks of Colombia and Brazil.

PubMed

Vargas, Ingrid; Mogollón-Pérez, Amparo Susana; De Paepe, Pierre; Ferreira da Silva, Maria Rejane; Unger, Jean-Pierre; Vázquez, María-Luisa

2016-07-01

Although integrated healthcare networks (IHNs) are promoted in Latin America in response to health system fragmentation, few analyses on the coordination of care across levels in these networks have been conducted in the region. The aim is to analyse the existence of healthcare coordination across levels of care and the factors influencing it from the health personnel' perspective in healthcare networks of two countries with different health systems: Colombia, with a social security system based on managed competition and Brazil, with a decentralized national health system. A qualitative, exploratory and descriptive-interpretative study was conducted, based on a case study of healthcare networks in four municipalities. Individual semi-structured interviews were conducted with a three stage theoretical sample of (a) health (112) and administrative (66) professionals of different care levels, and (b) managers of providers (42) and insurers (14). A thematic content analysis was conducted, segmented by cases, informant groups and themes. The results reveal poor clinical information transfer between healthcare levels in all networks analysed, with added deficiencies in Brazil in the coordination of access and clinical management. The obstacles to care coordination are related to the organization of both the health system and the healthcare networks. In the health system, there is the existence of economic incentives to compete (exacerbated in Brazil by partisan political interests), the fragmentation and instability of networks in Colombia and weak planning and evaluation in Brazil. In the healthcare networks, there are inadequate working conditions (temporary and/or part-time contracts) which hinder the use of coordination mechanisms, and inadequate professional training for implementing a healthcare model in which primary care should act as coordinator in patient care. Reforms are needed in these health systems and networks in order to modify incentives, strengthen the state planning and supervision functions and improve professional working conditions and skills. © The Author 2016. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine.

Transportation systems analyses: Volume 1: Executive Summary

NASA Astrophysics Data System (ADS)

1993-05-01

The principal objective of this study is to accomplish a systems engineering assessment of the nation's space transportation infrastructure. This analysis addresses the necessary elements to perform man delivery and return, cargo transfer, cargo delivery, payload servicing, and the exploration of the Moon and Mars. Specific elements analyzed, but not limited to, include the Space Exploration Initiative (SEI), the National Launch System (NLS), the current expendable launch vehicle (ELV) fleet, ground facilities, the Space Station Freedom (SSF), and other civil, military and commercial payloads. The performance of this study entails maintaining a broad perspective on the large number of transportation elements that could potentially comprise the U.S. space infrastructure over the next several decades. To perform this systems evaluation, top-level trade studies are conducted to enhance our understanding of the relationships between elements of the infrastructure. This broad 'infrastructure-level perspective' permits the identification of preferred infrastructures. Sensitivity analyses are performed to assure the credibility and usefulness of study results. This executive summary of the transportation systems analyses (TSM) semi-annual report addresses the SSF logistics resupply. Our analysis parallels the ongoing NASA SSF redesign effort. Therefore, there could be no SSF design to drive our logistics analysis. Consequently, the analysis attempted to bound the reasonable SSF design possibilities (and the subsequent transportation implications). No other strategy really exists until after a final decision is rendered on the SSF configuration.

More than meets the eye: Using cognitive work analysis to identify design requirements for future rail level crossing systems.

PubMed

Salmon, Paul M; Lenné, Michael G; Read, Gemma J M; Mulvihill, Christine M; Cornelissen, Miranda; Walker, Guy H; Young, Kristie L; Stevens, Nicholas; Stanton, Neville A

2016-03-01

An increasing intensity of operations means that the longstanding safety issue of rail level crossings is likely to become worse in the transport systems of the future. It has been suggested that the failure to prevent collisions may be, in part, due to a lack of systems thinking during design, crash analysis, and countermeasure development. This paper presents a systems analysis of current active rail level crossing systems in Victoria, Australia that was undertaken to identify design requirements to improve safety in future rail level crossing environments. Cognitive work analysis was used to analyse rail level crossing systems using data derived from a range of activities. Overall the analysis identified a range of instances where modification or redesign in line with systems thinking could potentially improve behaviour and safety. A notable finding is that there are opportunities for redesign outside of the physical rail level crossing infrastructure, including improved data systems, in-vehicle warnings and modifications to design processes, standards and guidelines. The implications for future rail level crossing systems are discussed. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

World Culture in the Capitalist World-System in Transition

ERIC Educational Resources Information Center

Griffiths, Tom G.; Arnove, Robert F.

2015-01-01

World culture theory (WCT) offers an explanatory framework for macro-level comparative analyses of systems of mass education, including their structures, accompanying policies and their curricular and pedagogical practices. WCT has contributed to broader efforts to overcome methodological nationalism in comparative research. In this paper, we…

Further Results of Soft-Inplane Tiltrotor Aeromechanics Investigation Using Two Multibody Analyses

NASA Technical Reports Server (NTRS)

Masarati, Pierangelo; Quaranta, Giuseppe; Piatak, David J.; Singleton, Jeffrey D.

2004-01-01

This investigation focuses on the development of multibody analytical models to predict the dynamic response, aeroelastic stability, and blade loading of a soft-inplane tiltrotor wind-tunnel model. Comprehensive rotorcraft-based multibody analyses enable modeling of the rotor system to a high level of detail such that complex mechanics and nonlinear effects associated with control system geometry and joint deadband may be considered. The influence of these and other nonlinear effects on the aeromechanical behavior of the tiltrotor model are examined. A parametric study of the design parameters which may have influence on the aeromechanics of the soft-inplane rotor system are also included in this investigation.

A New Vision for Teacher Professional Growth & Support: Six Steps to a More Powerful School System Strategy

ERIC Educational Resources Information Center

Education Resource Strategies, 2013

2013-01-01

One of a series of Education Resource Strategies (ERS) publications and tools, this paper explores important ways to organize and invest in Professional Growth & Support that strengthen teaching capacity and effectiveness at the system level. It draws on research, ERS experience with urban school systems nationwide, and detailed analyses of…

Lunar Exploration Architecture Level Key Drivers and Sensitivities

NASA Technical Reports Server (NTRS)

Goodliff, Kandyce; Cirillo, William; Earle, Kevin; Reeves, J. D.; Shyface, Hilary; Andraschko, Mark; Merrill, R. Gabe; Stromgren, Chel; Cirillo, Christopher

2009-01-01

Strategic level analysis of the integrated behavior of lunar transportation and lunar surface systems architecture options is performed to assess the benefit, viability, affordability, and robustness of system design choices. This analysis employs both deterministic and probabilistic modeling techniques so that the extent of potential future uncertainties associated with each option are properly characterized. The results of these analyses are summarized in a predefined set of high-level Figures of Merit (FOMs) so as to provide senior NASA Constellation Program (CxP) and Exploration Systems Mission Directorate (ESMD) management with pertinent information to better inform strategic level decision making. The strategic level exploration architecture model is designed to perform analysis at as high a level as possible but still capture those details that have major impacts on system performance. The strategic analysis methodology focuses on integrated performance, affordability, and risk analysis, and captures the linkages and feedbacks between these three areas. Each of these results leads into the determination of the high-level FOMs. This strategic level analysis methodology has been previously applied to Space Shuttle and International Space Station assessments and is now being applied to the development of the Constellation Program point-of-departure lunar architecture. This paper provides an overview of the strategic analysis methodology and the lunar exploration architecture analyses to date. In studying these analysis results, the strategic analysis team has identified and characterized key drivers affecting the integrated architecture behavior. These key drivers include inclusion of a cargo lander, mission rate, mission location, fixed-versus- variable costs/return on investment, and the requirement for probabilistic analysis. Results of sensitivity analysis performed on lunar exploration architecture scenarios are also presented.

Study on High Efficient Electric Vehicle Wireless Charging System

NASA Astrophysics Data System (ADS)

Chen, H. X.; Liu, Z. Z.; Zeng, H.; Qu, X. D.; Hou, Y. J.

2016-08-01

Electric and unmanned is a new trend in the development of automobile, cable charging pile can not meet the demand of unmanned electric vehicle. Wireless charging system for electric vehicle has a high level of automation, which can be realized by unmanned operation, and the wireless charging technology has been paid more and more attention. This paper first analyses the differences in S-S (series-series) and S-P (series-parallel) type resonant wireless power supply system, combined with the load characteristics of electric vehicle, S-S type resonant structure was used in this system. This paper analyses the coupling coefficient of several common coil structure changes with the moving distance of Maxwell Ansys software, the performance of disc type coil structure is better. Then the simulation model is established by Simulink toolbox in Matlab, to analyse the power and efficiency characteristics of the whole system. Finally, the experiment platform is set up to verify the feasibility of the whole system and optimize the system. Based on the theoretical and simulation analysis, the higher charging efficiency is obtained by optimizing the magnetic coupling mechanism.

The Representation of Extra-tropical Cyclones in Recent Re-Analyses: ERA-Interim, NASA-MERRA, NCEP-CFS and JRA25

NASA Astrophysics Data System (ADS)

Hodges, K.

2010-12-01

Re-analyses are produced using a forecast model, data assimilation system and historical observations. Whilst the observations are common between the re-analyses the way they are assimilated and the forecast model used are often different between the re-analyses which can introduce uncertainty in the representation of particular phenomena between the re-analyses, for example the distribution and properties of weather systems. It is important to inter-compare re-analyses to determine the uncertainty in their representation of the atmosphere, its circulation and weather systems in order to have confidence in their use for studies of the atmosphere and validating climate models. The four recent re-analyses, ERA-Interim, NASA-MERRA, NCEP-CFS and JRA25 are explored and compared for the representation of synoptic scale extra-tropical cyclones. Previous studies of the older re-analyses. ERA40, NCEP-NCAR and DOE has shown that whilst in the NH there was relatively good agreement between the re-analyses in terms of the distribution and properties of extra-tropical cyclones, in the SH there was much larger uncertainty. The newest re-analyses are produced at much higher resolutions than previous re-analyses, in addition more modern data assimilation systems and forecast models have been used. Hence, it would be hoped that the representation of cyclones will be improved to the same extent as that seen in modern NWP systems. This study contrasts extra-tropical cyclones, their distribution and properties, between these new re-analyses and compares them with cyclones in the slightly older though lower resolution JRA25 re-analysis. Results will show that in general in the higher resolution re-analysis more cyclones are identified than in JRA25. In the NH the distribution of storms agrees as well if not better than was the case for the older re-analyses. However, it is in the SH that the largest improvement in agreement is seen for the distribution of storms. For ERA-Interim, NASA-MERRA and NCEP-CFS the agreement in the SH is almost as good as in the NH with the best agreement occurring between ERA-Interim and NCEP-CFS. However, the comparison with JRA25 shows the same level of uncertainty as seen with the older re-analyses. Determining the separation distances of storms using storm matching confirm these results. The biggest differences between the re-analyses occurs for the intensity of storms with the NASA-MERRA having consistently the strongest extreme storms in terms of pressure and winds and JRA25 the weakest, ERA-Interim and NCEP-CFS are very similar in this respect. Using vorticity as an intensity measure shows the greatest sensitivity and goes with resolution. If time permits a comparison of the structure of the storms will also be presented. The approach used only highlights the uncertainty between the re-analyses it does not say which one is right. To try to address this some early results of comparing the re-analyses directly with observations of low level winds from scatterometers in the vicinity of storms will be presented if time permits.

Stepping Stones Triple P-Positive Parenting Program for children with disability: a systematic review and meta-analysis.

PubMed

Tellegen, Cassandra L; Sanders, Matthew R

2013-05-01

This systematic review and meta-analysis evaluated the treatment effects of a behavioral family intervention, Stepping Stones Triple P (SSTP) for parents of children with disabilities. SSTP is a system of five intervention levels of increasing intensity and narrowing population reach. Twelve studies, including a total of 659 families, met eligibility criteria. Studies needed to have evaluated SSTP, be written in English or German, contribute original data, and have sufficient data for analyses. No restrictions were placed on study design. A series of meta-analyses were performed for seven different outcome categories. Analyses were conducted on the combination of all four levels of SSTP for which evidence exists (Levels 2-5), and were also conducted separately for each level of SSTP. Significant moderate effect sizes were found for all levels of SSTP for reducing child problems, the primary outcome of interest. On secondary outcomes, significant overall effect sizes were found for parenting styles, parenting satisfaction and efficacy, parental adjustment, parental relationship, and observed child behaviors. No significant treatment effects were found for observed parenting behaviors. Moderator analyses showed no significant differences in effect sizes across the levels of SSTP intervention, with the exception of child observations. Risk of bias within and across studies was assessed. Analyses suggested that publication bias and selective reporting bias were not likely to have heavily influenced the findings. The overall evidence base supported the effectiveness of SSTP as an intervention for improving child and parent outcomes in families of children with disabilities. Limitations and future research directions are discussed. Copyright © 2013 Elsevier Ltd. All rights reserved.

Capacity Development for Education Systems in Fragile Contexts. Working Paper

ERIC Educational Resources Information Center

Davies, Lynn

2009-01-01

This paper examines fragility, capacity development and education and the links between these by analysing relevant research and policy literature. It proposes ways forward for action and reflection at national, regional and international levels. An important element of capacity development in education systems is the establishment of education…

The Many Forms of Research-Informed Practice: A Framework for Mapping Diversity

ERIC Educational Resources Information Center

Ostinelli, Giorgio

2016-01-01

This article investigates the interaction between educational research and practice in school systems, through a bi-dimensional framework. Forty-four papers were selected and analysed, and were grouped based on their pertinence to the categories: "system level" (macro-meso-micro) and "locus of need"…

Maternal Belief Systems: The Discourse of Cultural Practice as Evidence

ERIC Educational Resources Information Center

Mastergeorge, Ann M.

2007-01-01

Fully developed definitions of evidence-based practice incorporate evidence from family perspectives, as well as evidence from research on the effectiveness of particular interventions. Systems for appraising research evidence typically place qualitative analyses at lower levels. The argument in this article is that qualitative data offer a…

Future Directions for Engineering Education: System Response to a Changing World.

ERIC Educational Resources Information Center

Massachusetts Inst. of Tech., Cambridge. Center for Policy Alternatives.

This report consolidates information on the engineering population - numbers, employment patterns, educational levels, personality, technical obsolescence - and probes the implications of current social and employment trends. Included are: data and analyses of the engineering education system seen in the context of the changing world; the…

E-Learning Systems Support of Collaborative Agreements: A Theoretical Model

ERIC Educational Resources Information Center

Aguirre, Sandra; Quemada, Juan

2012-01-01

This paper introduces a theoretical model for developing integrated degree programmes through e-learning systems as stipulated by a collaboration agreement signed by two universities. We have analysed several collaboration agreements between universities at the national, European, and transatlantic level as well as various e-learning frameworks. A…

Back-Analyses of Landfill Instability Induced by High Water Level: Case Study of Shenzhen Landfill

PubMed Central

Peng, Ren; Hou, Yujing; Zhan, Liangtong; Yao, Yangping

2016-01-01

In June 2008, the Shenzhen landfill slope failed. This case is used as an example to study the deformation characteristics and failure mode of a slope induced by high water levels. An integrated monitoring system, including water level gauges, electronic total stations, and inclinometers, was used to monitor the slope failure process. The field measurements suggest that the landfill landslide was caused by a deep slip along the weak interface of the composite liner system at the base of the landfill. The high water level is considered to be the main factor that caused this failure. To calculate the relative interface shear displacements in the geosynthetic multilayer liner system, a series of numerical direct shear tests were carried out. Based on the numerical results, the composite lining system simplified and the centrifuge modeling technique was used to quantitatively evaluate the effect of water levels on landfill instability. PMID:26771627

Impact of a grout curtain on groundwater regime in karst: the example of the Ðale reservoir (Croatia)

NASA Astrophysics Data System (ADS)

Bonacci, Ognjen; Roje-Bonacci, Tanja

2010-05-01

Construction of grout curtains in karst terrains is primarily connected with dams and reservoirs. Their role is to increase watertightness and prevent progressive erosion. In this presentation hourly continuous measurement of groundwater level in two deep piezometers near the Đale reservoir is analysed. The Đale reservoir in the Cetina River began operation in 1989. The total length of the grout curtain is 3.9 km. It spreads 120 m bellow the Đale dam. First analysed piezometer A is drilled in the interior part of the system, between the reservoir and the grout curtain, while the second one B is located in its external part. Distance between them is 200 m. In natural conditions, prior the grout curtain construction, groundwater level fluctuation in both of them was similar (practically the same). Construction of the grout curtain extremely changed groundwater behaviour in each of them. During the six month of continuous monitoring, differences between groundwater levels in them range between +19.86 m (groundwater in B is lower than in A) and -12.77 m (groundwater in A is lower than in B). During the 77% of analysed period the groundwater level in interior piezometer A is higher than the groundwater level in external piezometer B. In other 23% of analysed period the groundwater level in outside piezometer B is higher than in inside A. The construction of the grout curtain caused unnaturally high hydrostatic gradients, which can accelerate the dissolutional expansion of karst fractures. As a result, unbearable leakage of the reservoir Đale can occur over its lifetime. Careful analyses of groundwater level behaviour discover some other very important characteristics of karst underground morphology.

Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

DTIC Science & Technology

2008-02-27

equivalent levels of expression of the spastin constructs, as assessed by fluorescence intensity of the Sp/AAA antibody staining. Microtu- bule levels...Errico A, Ballabio A, Rugarli EI (2002) Spastin, the protein mutated in au- tosomal dominant hereditary spastic paraplegia, is involved in microtu- bule

Industrial ecology: Quantitative methods for exploring a lower carbon future

NASA Astrophysics Data System (ADS)

Thomas, Valerie M.

2015-03-01

Quantitative methods for environmental and cost analyses of energy, industrial, and infrastructure systems are briefly introduced and surveyed, with the aim of encouraging broader utilization and development of quantitative methods in sustainable energy research. Material and energy flow analyses can provide an overall system overview. The methods of engineering economics and cost benefit analysis, such as net present values, are the most straightforward approach for evaluating investment options, with the levelized cost of energy being a widely used metric in electricity analyses. Environmental lifecycle assessment has been extensively developed, with both detailed process-based and comprehensive input-output approaches available. Optimization methods provide an opportunity to go beyond engineering economics to develop detailed least-cost or least-impact combinations of many different choices.

Bit-level quantum color image encryption scheme with quantum cross-exchange operation and hyper-chaotic system

NASA Astrophysics Data System (ADS)

Zhou, Nanrun; Chen, Weiwei; Yan, Xinyu; Wang, Yunqian

2018-06-01

In order to obtain higher encryption efficiency, a bit-level quantum color image encryption scheme by exploiting quantum cross-exchange operation and a 5D hyper-chaotic system is designed. Additionally, to enhance the scrambling effect, the quantum channel swapping operation is employed to swap the gray values of corresponding pixels. The proposed color image encryption algorithm has larger key space and higher security since the 5D hyper-chaotic system has more complex dynamic behavior, better randomness and unpredictability than those based on low-dimensional hyper-chaotic systems. Simulations and theoretical analyses demonstrate that the presented bit-level quantum color image encryption scheme outperforms its classical counterparts in efficiency and security.

Space Station Freedom electric power system availability study

NASA Technical Reports Server (NTRS)

Turnquist, Scott R.

1990-01-01

The results are detailed of follow-on availability analyses performed on the Space Station Freedom electric power system (EPS). The scope includes analyses of several EPS design variations, these are: the 4-photovoltaic (PV) module baseline EPS design, a 6-PV module EPS design, and a 3-solar dynamic module EPS design which included a 10 kW PV module. The analyses performed included: determining the discrete power levels that the EPS will operate at upon various component failures and the availability of each of these operating states; ranking EPS components by the relative contribution each component type gives to the power availability of the EPS; determining the availability impacts of including structural and long-life EPS components in the availability models used in the analyses; determining optimum sparing strategies, for storing space EPS components on-orbit, to maintain high average-power-capability with low lift-mass requirements; and analyses to determine the sensitivity of EPS-availability to uncertainties in the component reliability and maintainability data used.

[Governance in a project addressing care of disabled elderly persons within the regional healthcare system of Tuscany, Italy].

PubMed

Pedace, Claudio; Rosa, Antonella; Francesconi, Paolo; Acampora, Anna; Ricciardi, Walter; Damiani, Gianfranco

2017-01-01

Population aging and the concurrent increase of age-related chronic degenerative diseases and disability are associated with an increased proportion of elderly persons who are dependent in activities of daily living (ADL). ADL-dependent persons need continuous and long-term health and social care according to the "taking charge" rationale, in order to warrant access and continuity of care. A healthcare system needs to respond to the long-term and complex needs, such as those of disabled elderly people, by providing appropriate health and social care services in Primary Care. A Primary Health Care system is organized according to two governance levels have distinct aims but are closely inter-dependent in their operational mechanisms. The system governance is accountable for the community and individual health protection while the delivery governance is accountable for the provision of services in accordance with appropriateness, safety and economic criteria. Delivery governance can be considered "integrated governance" as a synergy exists between two decision-making systems guiding provider choices, which are corporate governance and clinical governance. The aim of this study was to analyse the abovementioned governance levels within the healthcare system in Tuscany (Italy) referring to long-term residential care for disabled elderly people. The case of excessive accesses to emergency departments from different types of Nursing Homes (NH) is used as an example to analyse different levels of responsibility involved in the management of a critical phenomenon. Suggestions for improvement in the different levels of governance for disabled elderly people are provided, in order to support institutional programming activities.

A Language for Specifying Compiler Optimizations for Generic Software

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willcock, Jeremiah J.

2007-01-01

Compiler optimization is important to software performance, and modern processor architectures make optimization even more critical. However, many modern software applications use libraries providing high levels of abstraction. Such libraries often hinder effective optimization — the libraries are difficult to analyze using current compiler technology. For example, high-level libraries often use dynamic memory allocation and indirectly expressed control structures, such as iteratorbased loops. Programs using these libraries often cannot achieve an optimal level of performance. On the other hand, software libraries have also been recognized as potentially aiding in program optimization. One proposed implementation of library-based optimization is to allowmore » the library author, or a library user, to define custom analyses and optimizations. Only limited systems have been created to take advantage of this potential, however. One problem in creating a framework for defining new optimizations and analyses is how users are to specify them: implementing them by hand inside a compiler is difficult and prone to errors. Thus, a domain-specific language for librarybased compiler optimizations would be beneficial. Many optimization specification languages have appeared in the literature, but they tend to be either limited in power or unnecessarily difficult to use. Therefore, I have designed, implemented, and evaluated the Pavilion language for specifying program analyses and optimizations, designed for library authors and users. These analyses and optimizations can be based on the implementation of a particular library, its use in a specific program, or on the properties of a broad range of types, expressed through concepts. The new system is intended to provide a high level of expressiveness, even though the intended users are unlikely to be compiler experts.« less

Design for testability and diagnosis at the system-level

NASA Technical Reports Server (NTRS)

Simpson, William R.; Sheppard, John W.

1993-01-01

The growing complexity of full-scale systems has surpassed the capabilities of most simulation software to provide detailed models or gate-level failure analyses. The process of system-level diagnosis approaches the fault-isolation problem in a manner that differs significantly from the traditional and exhaustive failure mode search. System-level diagnosis is based on a functional representation of the system. For example, one can exercise one portion of a radar algorithm (the Fast Fourier Transform (FFT) function) by injecting several standard input patterns and comparing the results to standardized output results. An anomalous output would point to one of several items (including the FFT circuit) without specifying the gate or failure mode. For system-level repair, identifying an anomalous chip is sufficient. We describe here an information theoretic and dependency modeling approach that discards much of the detailed physical knowledge about the system and analyzes its information flow and functional interrelationships. The approach relies on group and flow associations and, as such, is hierarchical. Its hierarchical nature allows the approach to be applicable to any level of complexity and to any repair level. This approach has been incorporated in a product called STAMP (System Testability and Maintenance Program) which was developed and refined through more than 10 years of field-level applications to complex system diagnosis. The results have been outstanding, even spectacular in some cases. In this paper we describe system-level testability, system-level diagnoses, and the STAMP analysis approach, as well as a few STAMP applications.

Presentation of the Coding and Assessment System for Narratives of Trauma (CASNOT): Application in Spanish Battered Women and Preliminary Analyses.

PubMed

Fernández-Lansac, Violeta; Crespo, María

2017-07-26

This study introduces a new coding system, the Coding and Assessment System for Narratives of Trauma (CASNOT), to analyse several language domains in narratives of autobiographical memories, especially in trauma narratives. The development of the coding system is described. It was applied to assess positive and traumatic/negative narratives in 50 battered women (trauma-exposed group) and 50 nontrauma-exposed women (control group). Three blind raters coded each narrative. Inter-rater reliability analyses were conducted for the CASNOT language categories (multirater Kfree coefficients) and dimensions (intraclass correlation coefficients). High levels of inter-rater agreement were found for most of the language domains. Categories that did not reach the expected reliability were mainly those related to cognitive processes, which reflects difficulties in operationalizing constructs such as lack of control or helplessness, control or planning, and rationalization or memory elaboration. Applications and limitations of the CASNOT are discussed to enhance narrative measures for autobiographical memories.

[Results of the marketing research study "Acceptance of physician's office computer systems"].

PubMed

Steinhausen, D; Brinkmann, F; Engelhard, A

1998-01-01

We report on a market research study on the acceptance of computer systems in surgeries. 11,000 returned questionnaires of surgeons--user and nonuser--were analysed. We found out that most of the surgeons used their computers in a limited way, i.e. as a device for accounting. Concerning the level of utilisation there are differentials of Men-Women, West-East and Young-Old. In this study we also analysed the computer using behaviour of gynaecologic surgeons. As a result two third of all nonusers are not intending to utilise a computer in the future.

State Special Education Finance Systems, 1999-2000. Part II: Special Education Revenues and Expenditures

ERIC Educational Resources Information Center

Parrish, Thomas; Harr, Jenifer; Wolman, Jean; Anthony, Jennifer; Merickel, Amy; Esra, Phil

2004-01-01

The Center for Special Education Finance (CSEF) provides policymakers and administrators at all governmental levels with data, analyses, expertise, and opportunities to share information about special education finance issues. One of CSEF's major activities is the periodic collection and dissemination of information on state funding systems for…

Report of the LSPI/NASA Workshop on Lunar Base Methodology Development

NASA Technical Reports Server (NTRS)

Nozette, Stewart; Roberts, Barney

1985-01-01

Groundwork was laid for computer models which will assist in the design of a manned lunar base. The models, herein described, will provide the following functions for the successful conclusion of that task: strategic planning; sensitivity analyses; impact analyses; and documentation. Topics addressed include: upper level model description; interrelationship matrix; user community; model features; model descriptions; system implementation; model management; and plans for future action.

Genetic variations in the serotonergic system contribute to amygdala volume in humans

PubMed Central

Li, Jin; Chen, Chunhui; Wu, Karen; Zhang, Mingxia; Zhu, Bi; Chen, Chuansheng; Moyzis, Robert K.; Dong, Qi

2015-01-01

The amygdala plays a critical role in emotion processing and psychiatric disorders associated with emotion dysfunction. Accumulating evidence suggests that amygdala structure is modulated by serotonin-related genes. However, there is a gap between the small contributions of single loci (less than 1%) and the reported 63–65% heritability of amygdala structure. To understand the “missing heritability,” we systematically explored the contribution of serotonin genes on amygdala structure at the gene set level. The present study of 417 healthy Chinese volunteers examined 129 representative polymorphisms in genes from multiple biological mechanisms in the regulation of serotonin neurotransmission. A system-level approach using multiple regression analyses identified that nine SNPs collectively accounted for approximately 8% of the variance in amygdala volume. Permutation analyses showed that the probability of obtaining these findings by chance was low (p = 0.043, permuted for 1000 times). Findings showed that serotonin genes contribute moderately to individual differences in amygdala volume in a healthy Chinese sample. These results indicate that the system-level approach can help us to understand the genetic basis of a complex trait such as amygdala structure. PMID:26500508

A Low Cost, Self Acting, Liquid Hydrogen Boil-Off Recovery System

NASA Technical Reports Server (NTRS)

Pelfrey, Joy W.; Sharp, Kirk V. (Technical Monitor)

2001-01-01

The purpose of this research was to develop a prototype liquid hydrogen boll-off recovery system. Perform analyses to finalize recovery system cycle, design detail components, fabricate hardware, and conduct sub-component, component, and system level tests leading to the delivery of a prototype system. The design point and off-design analyses identified cycle improvements to increase the robustness of the system by adding a by-pass heat exchanger. Based on the design, analysis, and testing conducted, the recovery system will liquefy 31% of the gaseous boil off from a liquid hydrogen storage tank. All components, including a high speed, miniature turbocompressor, were designed and manufacturing drawings were created. All hardware was fabricated and tests were conducted in air, helium, and hydrogen. Testing validated the design, except for the turbocompressor. A rotor-to-stator clearance issue was discovered as a result of a concentricity tolerance stack-up.

Planning for Downtown Circulation Systems. Volume 2. Analysis Techniques.

DOT National Transportation Integrated Search

1983-10-01

This volume contains the analysis and refinement stages of downtown circulator planning. Included are sections on methods for estimating patronage, costs, revenues, and impacts, and a section on methods for performing micro-level analyses.

Elevated systemic galectin-1 levels characterize HELLP syndrome.

PubMed

Schnabel, Annegret; Blois, Sandra M; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; Barrientos, Gabriela; Conrad, Melanie L; Rose, Matthias; Seelbach-Göbel, Birgit

2016-04-01

Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Electric power system test and verification program

NASA Technical Reports Server (NTRS)

Rylicki, Daniel S.; Robinson, Frank, Jr.

1994-01-01

Space Station Freedom's (SSF's) electric power system (EPS) hardware and software verification is performed at all levels of integration, from components to assembly and system level tests. Careful planning is essential to ensure the EPS is tested properly on the ground prior to launch. The results of the test performed on breadboard model hardware and analyses completed to date have been evaluated and used to plan for design qualification and flight acceptance test phases. These results and plans indicate the verification program for SSF's 75-kW EPS would have been successful and completed in time to support the scheduled first element launch.

NEXT Ion Thruster Performance Dispersion Analyses

NASA Technical Reports Server (NTRS)

Soulas, George C.; Patterson, Michael J.

2008-01-01

The NEXT ion thruster is a low specific mass, high performance thruster with a nominal throttling range of 0.5 to 7 kW. Numerous engineering model and one prototype model thrusters have been manufactured and tested. Of significant importance to propulsion system performance is thruster-to-thruster performance dispersions. This type of information can provide a bandwidth of expected performance variations both on a thruster and a component level. Knowledge of these dispersions can be used to more conservatively predict thruster service life capability and thruster performance for mission planning, facilitate future thruster performance comparisons, and verify power processor capabilities are compatible with the thruster design. This study compiles the test results of five engineering model thrusters and one flight-like thruster to determine unit-to-unit dispersions in thruster performance. Component level performance dispersion analyses will include discharge chamber voltages, currents, and losses; accelerator currents, electron backstreaming limits, and perveance limits; and neutralizer keeper and coupling voltages and the spot-to-plume mode transition flow rates. Thruster level performance dispersion analyses will include thrust efficiency.

Performance Evaluation of Multimodal Multifeature Authentication System Using KNN Classification.

PubMed

Rajagopal, Gayathri; Palaniswamy, Ramamoorthy

2015-01-01

This research proposes a multimodal multifeature biometric system for human recognition using two traits, that is, palmprint and iris. The purpose of this research is to analyse integration of multimodal and multifeature biometric system using feature level fusion to achieve better performance. The main aim of the proposed system is to increase the recognition accuracy using feature level fusion. The features at the feature level fusion are raw biometric data which contains rich information when compared to decision and matching score level fusion. Hence information fused at the feature level is expected to obtain improved recognition accuracy. However, information fused at feature level has the problem of curse in dimensionality; here PCA (principal component analysis) is used to diminish the dimensionality of the feature sets as they are high dimensional. The proposed multimodal results were compared with other multimodal and monomodal approaches. Out of these comparisons, the multimodal multifeature palmprint iris fusion offers significant improvements in the accuracy of the suggested multimodal biometric system. The proposed algorithm is tested using created virtual multimodal database using UPOL iris database and PolyU palmprint database.

Performance Evaluation of Multimodal Multifeature Authentication System Using KNN Classification

PubMed Central

Rajagopal, Gayathri; Palaniswamy, Ramamoorthy

2015-01-01

This research proposes a multimodal multifeature biometric system for human recognition using two traits, that is, palmprint and iris. The purpose of this research is to analyse integration of multimodal and multifeature biometric system using feature level fusion to achieve better performance. The main aim of the proposed system is to increase the recognition accuracy using feature level fusion. The features at the feature level fusion are raw biometric data which contains rich information when compared to decision and matching score level fusion. Hence information fused at the feature level is expected to obtain improved recognition accuracy. However, information fused at feature level has the problem of curse in dimensionality; here PCA (principal component analysis) is used to diminish the dimensionality of the feature sets as they are high dimensional. The proposed multimodal results were compared with other multimodal and monomodal approaches. Out of these comparisons, the multimodal multifeature palmprint iris fusion offers significant improvements in the accuracy of the suggested multimodal biometric system. The proposed algorithm is tested using created virtual multimodal database using UPOL iris database and PolyU palmprint database. PMID:26640813

Very preterm infants can detect small variations in light levels in incubators.

PubMed

Zores, Claire; Dufour, André; Pebayle, Thierry; Langlet, Claire; Astruc, Dominique; Kuhn, Pierre

2015-10-01

This prospective observational study was designed to improve our understanding of the responses of very preterm infants to light level variations in incubators and to evaluate what determined those reactions. The physiological responses of 27 very preterm infants were analysed following variations in the light level environments of their incubators over 10 hours. Heart and respiratory rates, systemic oxygen saturation and regional cerebral oxygen saturations were recorded using near-infrared spectroscopy, and the variation of each parameter was analysed. We analysed 332 light level changes. Heart rate increased by 3.8 beats per minute (range -2.6 to 12.6), respiratory rate by six cycles per minute (-1.5 to 26) and regional cerebral oxygen saturation by 1.1% (-0.5% to 3.9%) (p < 0.05 each) when delta lux was over 50. Only respiratory rate decreased significantly, by -8.4 cycles per minute (-28 to -0.4), when delta lux was 50 or lower (p < 0.05). The initial level of illumination altered the very preterm infants' responses, with higher reactivity for higher ambient light levels. Very preterm infants reacted to moderate variations in illumination in their incubator, within recommended ranges of light levels, suggesting that they may detect even small light level variations. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Laser fluorescence spectrometers for medical diagnosis

NASA Astrophysics Data System (ADS)

Kwasny, Miroslaw; Mierczyk, Zygmunt

2000-11-01

The paper presents fibre fluorescence analysers for in vivo examined biological tissues. The systems devoted to clinical investigations are equipped with laser excitation sources; He-Cd (442 nm), Nd:YAG (II and III harmonic: 532 and 355 nm, respectively) and He-Ne (632.8 nm). They allow non-invasive determination of endogenous fluorophones level in any organs as well as monitoring of external sensitisers level when photodynamic method of diagnosis and treatment of tumors is used. Selection of various wavelengths within the range of porphyrines, excitation depends on different light penetration in various tissues. For the tumors localised under mucous membrane, UV, violet, and blue radiation was used for excitation and for deeply localised tumors, a radiation of longer wavelengths (green and red) was used. The carried out clinical examinations showed usefulness of fluorometric systems for diagnostics of skin diseases, gynaecological spheres, and pneumopathies. These analysers can be also applied for environmental protection, food control, and industrial processes monitoring.

Mapping neurotransmitter networks with PET: an example on serotonin and opioid systems.

PubMed

Tuominen, Lauri; Nummenmaa, Lauri; Keltikangas-Järvinen, Liisa; Raitakari, Olli; Hietala, Jarmo

2014-05-01

All functions of the human brain are consequences of altered activity of specific neural pathways and neurotransmitter systems. Although the knowledge of "system level" connectivity in the brain is increasing rapidly, we lack "molecular level" information on brain networks and connectivity patterns. We introduce novel voxel-based positron emission tomography (PET) methods for studying internal neurotransmitter network structure and intercorrelations of different neurotransmitter systems in the human brain. We chose serotonin transporter and μ-opioid receptor for this analysis because of their functional interaction at the cellular level and similar regional distribution in the brain. Twenty-one healthy subjects underwent two consecutive PET scans using [(11)C]MADAM, a serotonin transporter tracer, and [(11)C]carfentanil, a μ-opioid receptor tracer. First, voxel-by-voxel "intracorrelations" (hub and seed analyses) were used to study the internal structure of opioid and serotonin systems. Second, voxel-level opioid-serotonin intercorrelations (between neurotransmitters) were computed. Regional μ-opioid receptor binding potentials were uniformly correlated throughout the brain. However, our analyses revealed nonuniformity in the serotonin transporter intracorrelations and identified a highly connected local network (midbrain-striatum-thalamus-amygdala). Regionally specific intercorrelations between the opioid and serotonin tracers were found in anteromedial thalamus, amygdala, anterior cingulate cortex, dorsolateral prefrontal cortex, and left parietal cortex, i.e., in areas relevant for several neuropsychiatric disorders, especially affective disorders. This methodology enables in vivo mapping of connectivity patterns within and between neurotransmitter systems. Quantification of functional neurotransmitter balances may be a useful approach in etiological studies of neuropsychiatric disorders and also in drug development as a biomarker-based rationale for targeted modulation of neurotransmitter networks. Copyright © 2013 Wiley Periodicals, Inc.

Problems and Alternatives in the Combat Rescue of Navy Aircrewmen

DTIC Science & Technology

1980-11-01

33 Objectives for an Improved Combat Rescue System ................................. 33 Decrease Injury Rate...altitudes as low as 50 feet above ground level. Extremity rest aint systems, constantly being improved, are reducing the number of injuries resulting...These analyses established causal factors associated with the injuries and problems occurring during the ejection-through.survival sequence. Later

A Novel Method for the In-Depth Multimodal Analysis of Student Learning Trajectories in Intelligent Tutoring Systems

ERIC Educational Resources Information Center

Liu, Ran; Stamper, John; Davenport, Jodi

2018-01-01

Temporal analyses are critical to understanding learning processes, yet understudied in education research. Data from different sources are often collected at different grain sizes, which are difficult to integrate. Making sense of data at many levels of analysis, including the most detailed levels, is highly time-consuming. In this paper, we…

HbA2 levels in β-thalassaemia carriers with the Filipino β0-deletion: are the levels higher than what is found with non-deletional forms of β0-thalassaemia?

PubMed

George, E; Teh, Lai Kuan; Tan, Jama; Lai, Mei I; Wong, Lily

2013-01-01

Classical carriers of β-thalassaemia are identified by a raised HbA2 level. Earlier studies indicated that the Filipino β-deletion has high raised HbA2 levels. The introduction of automated high performance liquid chromatography (HPLC) for thalassaemia screening is an important advance in technology for haematology laboratories. The BioRad Variant II Hb analyser is a common instrument used to quantify HbA2 levels in thalassaemia screening. This study aimed to determine HbA2 levels in carriers of Filipino β-mutation using the BioRad Variant II Hb analyser. The Filipino β-deletion was identified using gap-polymerase chain reaction (PCR) in the parents of transfusion dependent β-thalassaemia patients who were homozygous for the Filipino β-deletion in the indigenous population of Sabah, Malaysia. Hb subtypes were quantified on the BioRad Variant II Hb analyser. Concurrent α-thalassaemia was identified by multiplex gap-PCR for deletions and amplification refractory mutation system (ARMS)-PCR for non-deletional mutations. The mean HbA2 level for Filipino β-thalassaemia trait was 5.9 ± 0.47 and with coinheritance of α-thalassaemia was 6.3 ± 0.44 (-α heterozygous) and 6.7 ± 0.36 (-α homozygous). The HbA2 levels were all >4% in keeping with the findings of classical β-thalassaemia trait and significantly higher than levels seen in non-deletional forms of β-thalassaemia. The HbA2 level measured on the BioRad Variant II Hb analyser was lower than the level in the first description of the Filipino β-thalassaemia. β-thalassaemia trait with coinheritance of α-thalassaemia (-α) is associated with significantly higher HbA2 level.

Maturity analysis of the innovation system in the livestock industries of West Sumatra, Indonesia

NASA Astrophysics Data System (ADS)

Suresti, A.; Dinata, U. G. S.; Wati, R.

2018-02-01

The main objective of this study was to analyse the ANIS of Livestock industry in West Sumatera according to its main determinants. This research aims to know and understand the maturity level of the regional innovationsystem of West Sumatra livestock industries, including recommendation for improvements. The maturity level of the regional innovation system was analyzed with the ANIS method by using an opinion survey to some experts from businessmen, government and universities. This expert opinion survey was conducted to measure expert perceptions on the implementations of determinants of west Sumatera regional innovations systems on livestock industries on macro level (innovations policy), mezzo level (innovation institutions and programs) and micro level (innovation capacity). By using Likert method, the result showed maturity level for the West Sumatra livestock industries innovation system was still develop. This is caused by low maturity in the macro and meso determinants which are at the central and regional government side. This research result may be useful as recommendations for the government for improving the maturity level and may be a basic for incoming researches to identify regional innovation system determinants with low maturity to improve.

Space Transfer Vehicle Concepts and Requirements Study. Volume 2, Book 2: System and Program Requirements Trade Studies

NASA Technical Reports Server (NTRS)

Weber, Gary A.

1991-01-01

During the 90-day study, support was provided to NASA in defining a point-of-departure space transfer vehicle (STV). The resulting STV concept was performance optimized with a two-stage LTV/LEV configuration. Appendix A reports on the effort during this period of the study. From the end of the 90-day study until the March Interim Review, effort was placed on optimizing the two-stage vehicle approach identified in the 90-day effort. After the March Interim Review, the effort was expanded to perform a full architectural trade study with the intent of developing a decision database to support STV system decisions in response to changing SEI infrastructure concepts. Several of the architecture trade studies were combined in a System Architecture Trade Study. In addition to this trade, system optimization/definition trades and analyses were completed and some special topics were addressed. Program- and system-level trade study and analyses methodologies and results are presented in this section. Trades and analyses covered in this section are: (1) a system architecture trade study; (2) evolution; (3) safety and abort considerations; (4) STV as a launch vehicle upper stage; and (5) optimum crew and cargo split.

The Effects of Post-Compulsory Education and Training Systems on Literacy and Numeracy Skills: A Comparative Analysis Using PISA 2000 and the 2011 Survey of Adult Skills

ERIC Educational Resources Information Center

Pensiero, Nicola; Green, Andy

2018-01-01

This article analyses the contribution of post-compulsory education and training systems to the development of literacy and numeracy skills across OECD countries. While there is extensive cross-country comparative research on the effects of primary and lower secondary education systems on aggregate skills levels, there has been little comparative…

Characteristics of future Vertical Axis Wind Turbines (VAWTs). [to generate utility grid electric power

NASA Technical Reports Server (NTRS)

Kadlec, E. G.

1979-01-01

The developing Darrieus VAWT technology whose ultimate objective is economically feasible, industry-produced, commercially marketed wind energy systems is reviewed. First-level aerodynamic, structural, and system analyses capabilities which support and evaluate the system designs are discussed. The characteristics of current technology designs are presented and their cost effectiveness is assessed. Potential improvements identified are also presented along with their cost benefits.

Comparative analysis of heat pump and biomass boiler for small detached house heating

NASA Astrophysics Data System (ADS)

Olkowski, Tomasz; Lipiński, Seweryn; Olędzka, Aneta

2017-10-01

The purpose of the work is to answer the question - which of the two selected heat sources is more economically beneficial for small detached house: heat pump or biomass boiler fuelled with wood-pellets? The comparative analysis of these sources was carried out to discuss the issue. First, cost of both, equipment and operation of selected heat systems were analysed. Additionally, CO2 emission levels associated with these heat systems were determined. The comparative analysis of the costs of both considered heat systems showed that equipment cost of heat pump system is considerably bigger than the cost of biomass boiler system. The comparison of annual operation costs showed that heat pump operation cost is slightly lower than operation cost of biomass boiler. The analysis of above results shows that lower operation cost of heat pump in comparison with biomass boiler cost lets qualify heat pump as more economically justified only after 38 years of work. For both analysed devices, CO2 emission levels were determined. The considerations take into account the fact that heat pump consumes electricity. It is mostly generated through combustion of coal in Poland. The results show that in Poland biomass boiler can be described as not only more economically justified system but also as considerably more ecological.

20 Meter Solar Sail Analysis and Correlation

NASA Technical Reports Server (NTRS)

Taleghani, B. K.; Lively, P. S.; Banik, J.; Murphy, D. M.; Trautt, T. A.

2005-01-01

This paper describes finite element analyses and correlation studies to predict deformations and vibration modes/frequencies of a 20-meter solar sail system developed by ATK Space Systems. Under the programmatic leadership of NASA Marshall Space Flight Center's In-Space Propulsion activity, the 20-meter solar sail program objectives were to verify the design, to assess structural responses of the sail system, to implement lessons learned from a previous 10-meter quadrant system analysis and test program, and to mature solar sail technology to a technology readiness level (TRL) of 5. For this 20 meter sail system, static and ground vibration tests were conducted in NASA Glenn Research Center's 100 meter diameter vacuum chamber at Plum Brook station. Prior to testing, a preliminary analysis was performed to evaluate test conditions and to determine sensor and actuator locations. After testing was completed, an analysis of each test configuration was performed. Post-test model refinements included updated properties to account for the mass of sensors, wiring, and other components used for testing. This paper describes the development of finite element models (FEM) for sail membranes and masts in each of four quadrants at both the component and system levels, as well as an optimization procedure for the static test/analyses correlation.

Evaluating coastal and river valley communities evacuation network performance using macroscopic productivity.

DOT National Transportation Integrated Search

2017-06-30

The ever-increasing processing speed and computational power of computers and simulation systems has led to correspondingly larger, more sophisticated representations of evacuation traffic processes. Today, micro-level analyses can be conducted for m...

Heat Shock Factor 1 Deficiency Affects Systemic Body Temperature Regulation.

PubMed

Ingenwerth, Marc; Noichl, Erik; Stahr, Anna; Korf, Horst-Werner; Reinke, Hans; von Gall, Charlotte

2016-01-01

Heat shock factor 1 (HSF1) is a ubiquitous heat-sensitive transcription factor that mediates heat shock protein transcription in response to cellular stress, such as increased temperature, in order to protect the organism against misfolded proteins. In this study, we analysed the effect of HSF1 deficiency on core body temperature regulation. Body temperature, locomotor activity, and food consumption of wild-type mice and HSF1-deficient mice were recorded. Prolactin and thyroid-stimulating hormone levels were measured by ELISA. Gene expression in brown adipose tissue was analysed by quantitative real-time PCR. Hypothalamic HSF1 and its co-localisation with tyrosine hydroxylase was analysed using confocal laser scanning microscopy. HSF1-deficient mice showed an increase in core body temperature (hyperthermia), decreased overall locomotor activity, and decreased levels of prolactin in pituitary and blood plasma reminiscent of cold adaptation. HSF1 could be detected in various hypothalamic regions involved in temperature regulation, suggesting a potential role of HSF1 in hypothalamic thermoregulation. Moreover, HSF1 co-localises with tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, suggesting a potential role of HSF1 in the hypothalamic control of prolactin release. In brown adipose tissue, levels of prolactin receptor and uncoupled protein 1 were increased in HSF1-deficient mice, consistent with an up-regulation of heat production. Our data suggest a role of HSF1 in systemic thermoregulation. © 2015 S. Karger AG, Basel.

Use of active control technology to improve ride qualities of large transport aircraft

NASA Technical Reports Server (NTRS)

Cohen, G. C.; Cotter, C. J.; Taylor, D. L.

1976-01-01

Analyses, construction and flight testing of two systems: Beta-vane and Modal Suppression Augmentation System (MSAS), which were developed to suppress gust induced lateral accelerations of large aircraft, are described. The 747 transport was used as the test vehicle. The purpose of the Beta-vane system is to reduce acceleration levels at the dutch roll frequency whereas the function of the MSAS system is to reduce accelerations due to flexible body motions caused by turbulence. Data from flight test, with both systems engaged shows a 50 to 70 percent reduction in lateral aft body acceleration levels. Furthermore, it is suggested that present day techniques used for developing dynamic equations of motion in the flexible mode region are limited.

Optimal control of population and coherence in three-level Λ systems

NASA Astrophysics Data System (ADS)

Kumar, Praveen; Malinovskaya, Svetlana A.; Malinovsky, Vladimir S.

2011-08-01

Optimal control theory (OCT) implementations for an efficient population transfer and creation of maximum coherence in a three-level system are considered. We demonstrate that the half-stimulated Raman adiabatic passage scheme for creation of the maximum Raman coherence is the optimal solution according to the OCT. We also present a comparative study of several implementations of OCT applied to the complete population transfer and creation of the maximum coherence. Performance of the conjugate gradient method, the Zhu-Rabitz method and the Krotov method has been analysed.

Perceptions of adults with hearing impairment regarding the promotion of trust in hearing healthcare service delivery.

PubMed

Preminger, Jill E; Oxenbøll, Maria; Barnett, Margaret B; Jensen, Lisbeth D; Laplante-Lévesque, Ariane

2015-01-01

This paper describes how trust is promoted in adults with hearing impairment within the context of hearing healthcare (HHC) service delivery. Data were analysed from a previously published descriptive qualitative study that explored perspectives of adults with hearing impairment on hearing help-seeking and rehabilitation. Interview transcripts from 29 adults from four countries with different levels of hearing impairment and different experience with the HHC system were analysed thematically. Patients enter into the HHC system with service expectations resulting in a preconceived level of trust that can vary from low to high. Relational competence, technical competence, commercialized approach, and clinical environment (relevant to both the clinician and the clinic) influence a patient's resulting level of trust. Trust is evolving rather than static in HHC: Both clinicians and clinics can promote trust. The characteristics of HHC that engender trust are: practicing good communication, supporting shared decision making, displaying technical competence, offering comprehensive hearing rehabilitation, promoting self-management, avoiding a focus on hearing-aid sales, and offering a professional clinic setting.

Coherent population trapping resonances at lower atomic levels of Doppler broadened optical lines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Şahin, E; Hamid, R; Çelik, M

2014-11-30

We have detected and analysed narrow high-contrast coherent population trapping (CPT) resonances, which are induced in absorption of a weak monochromatic probe light beam by counterpropagating two-frequency pump radiation in a cell with rarefied caesium vapour. The experimental investigations have been performed by the example of nonclosed three level Λ-systems formed by spectral components of the D{sub 2} line of caesium atoms. The applied method allows one to analyse features of the CPT phenomenon directly at a given low long-lived level of the selected Λ-system even in sufficiently complicated spectra of atomic gases with large Doppler broadening. We have establishedmore » that CPT resonances in transmission of the probe beam exhibit not only a higher contrast but also a much lesser width in comparison with well- known CPT resonances in transmission of the corresponding two-frequency pump radiation. The results obtained can be used in selective photophysics, photochemistry and ultra-high resolution atomic (molecular) spectroscopy. (laser applications and other topics in quantum electronics)« less

A systems approach to bone pathophysiology.

PubMed

Weiss, Aaron J; Lipshtat, Azi; Mechanick, Jeffrey I

2010-11-01

With evolving interest in multiscalar biological systems one could assume that reductionist approaches may not fully describe biological complexity. Instead, tools such as mathematical modeling, network analysis, and other multiplexed clinical- and research-oriented tests enable rapid analyses of high-throughput data parsed at the genomic, proteomic, metabolomic, and physiomic levels. A physiomic-level approach allows for recursive horizontal and vertical integration of subsystem coupling across and within spatiotemporal scales. Additionally, this methodology recognizes previously ignored subsystems and the strong, nonintuitively obvious and indirect connections among physiological events that potentially account for the uncertainties in medicine. In this review, we flip the reductionist research paradigm and review the concept of systems biology and its applications to bone pathophysiology. Specifically, a bone-centric physiome model is presented that incorporates systemic-level processes with their respective therapeutic implications. © 2010 New York Academy of Sciences.

Exploratory Factor Analyses of the CAHPS® Hospital Pilot Survey Responses across and within Medical, Surgical, and Obstetric Services

PubMed Central

O'Malley, A James; Zaslavsky, Alan M; Hays, Ron D; Hepner, Kimberly A; Keller, San; Cleary, Paul D

2005-01-01

Objectives To estimate the associations among hospital-level scores from the Consumer Assessments of Healthcare Providers and Systems (CAHPS®) Hospital pilot survey within and across different services (surgery, obstetrics, medical), and to evaluate differences between hospital- and patient-level analyses. Data Source CAHPS Hospital pilot survey data provided by the Centers for Medicare and Medicaid Services. Study Design Responses to 33 questionnaire items were analyzed using patient- and hospital-level exploratory factor analytic (EFA) methods to identify both a patient-level and hospital-level composite structures for the CAHPS Hospital survey. The latter EFA was corrected for patient-level sampling variability using a hierarchical model. We compared results of these analyses with each other and to separate EFAs conducted at the service level. To quantify the similarity of assessments across services, we compared correlations of different composites within the same service with those of the same composite across different services. Data Collection Cross-sectional data were collected during the summer of 2003 via mail and telephone from 19,720 patients discharged from November 2002 through January 2003 from 132 hospitals in three states. Principal Findings Six factors provided the best description of inter-item covariation at the patient level. Analyses that assessed variability across both services and hospitals suggested that three dimensions provide a parsimonious summary of inter-item covariation at the hospital level. Hospital-level factor structures also differed across services; as much variation in quality reports was explained by service as by composite. Conclusions Variability of CAHPS scores across hospitals can be reported parsimoniously using a limited number of composites. There is at least as much distinct information in composite scores from different services as in different composite scores within each service. Because items cluster slightly differently in the different services, service-specific composites may be more informative when comparing patients in a given service across hospitals. When studying individual-level variability, a more differentiated structure is probably more appropriate. PMID:16316439

Microwave scanning beam landing system compatibility and performance: Engineering analyses 75-1 and 75-2. [space shuttle orbiter landing

NASA Technical Reports Server (NTRS)

1977-01-01

The microwave scanning beam landing system (MSBLS) is the primary position sensor of the Orbiter's navigation subsystem during the autoland phase of the flight. Portions of the system are discussed with special emphasis placed on potential problem areas as referenced to the Orbiter's mission. Topics discussed include system compatability, system accuracy, and expected RF signal levels. A block and flow diagram of MSBLS system operation is included with a list of special tests required to determine system performance.

Examination of Triacylglycerol Biosynthetic Pathways via De Novo Transcriptomic and Proteomic Analyses in an Unsequenced Microalga

PubMed Central

Guarnieri, Michael T.; Nag, Ambarish; Smolinski, Sharon L.; Darzins, Al; Seibert, Michael; Pienkos, Philip T.

2011-01-01

Biofuels derived from algal lipids represent an opportunity to dramatically impact the global energy demand for transportation fuels. Systems biology analyses of oleaginous algae could greatly accelerate the commercialization of algal-derived biofuels by elucidating the key components involved in lipid productivity and leading to the initiation of hypothesis-driven strain-improvement strategies. However, higher-level systems biology analyses, such as transcriptomics and proteomics, are highly dependent upon available genomic sequence data, and the lack of these data has hindered the pursuit of such analyses for many oleaginous microalgae. In order to examine the triacylglycerol biosynthetic pathway in the unsequenced oleaginous microalga, Chlorella vulgaris, we have established a strategy with which to bypass the necessity for genomic sequence information by using the transcriptome as a guide. Our results indicate an upregulation of both fatty acid and triacylglycerol biosynthetic machinery under oil-accumulating conditions, and demonstrate the utility of a de novo assembled transcriptome as a search model for proteomic analysis of an unsequenced microalga. PMID:22043295

Crisis management systems: staff nurses demand more support from their supervisors.

PubMed

Tzeng, Huey-Ming; Yin, Chang-Yi

2008-08-01

This study illustrates the contributions of the necessity, comprehensiveness, and difference (between necessity and comprehensiveness) levels of crisis management systems to participants' general satisfaction with their working institutions' nursing-related crisis management activities. Crisis management systems include strategic, technical/structural, assessment, public communication, and psychological/cultural aspects. An effective institutional crisis management system might help to decrease the number of incidents related to medical disputes or to prevent a crisis from worsening and becoming disastrous. A cross-sectional survey was administered during a nursing conference held in Taipei, Taiwan, on June 27, 2005. Two hundred ninety questionnaires were distributed, and 121 were retrieved (response rate, 41.7%; nursing administrators and staff). Univariate and multivariate analyses were performed. Ordinal logistic regression analyses show that being a public hospital managed by the government and having more difference on the strategic aspect between the necessity and comprehensiveness levels contribute to lower satisfaction with nursing-related crisis management activities (Nagelkerke R(2) = .441). In addition, staff nurses perceive higher necessity levels on all five aspects compared to nursing administrators. This study provides important insights into how the policies and activities of a medical institution's crisis management system can be prioritized and implemented. It is also important for students in nursing programs and for currently employed nurses to learn how to manage disputes related to nursing practice, so that early resolution can be achieved and crises can be avoided. These results suggest that staff nurses demand more support from their supervisors.

Crop Species Diversity Changes in the United States: 1978–2012

PubMed Central

Aguilar, Jonathan; Gramig, Greta G.; Hendrickson, John R.; Archer, David W.; Forcella, Frank; Liebig, Mark A.

2015-01-01

Anecdotal accounts regarding reduced US cropping system diversity have raised concerns about negative impacts of increasingly homogeneous cropping systems. However, formal analyses to document such changes are lacking. Using US Agriculture Census data, which are collected every five years, we quantified crop species diversity from 1978 to 2012, for the contiguous US on a county level basis. We used Shannon diversity indices expressed as effective number of crop species (ENCS) to quantify crop diversity. We then evaluated changes in county-level crop diversity both nationally and for each of the eight Farm Resource Regions developed by the National Agriculture Statistics Service. During the 34 years we considered in our analyses, both national and regional ENCS changed. Nationally, crop diversity was lower in 2012 than in 1978. However, our analyses also revealed interesting trends between and within different Resource Regions. Overall, the Heartland Resource Region had the lowest crop diversity whereas the Fruitful Rim and Northern Crescent had the highest. In contrast to the other Resource Regions, the Mississippi Portal had significantly higher crop diversity in 2012 than in 1978. Also, within regions there were differences between counties in crop diversity. Spatial autocorrelation revealed clustering of low and high ENCS and this trend became stronger over time. These results show that, nationally counties have been clustering into areas of either low diversity or high diversity. Moreover, a significant trend of more counties shifting to lower rather than to higher crop diversity was detected. The clustering and shifting demonstrates a trend toward crop diversity loss and attendant homogenization of agricultural production systems, which could have far-reaching consequences for provision of ecosystem system services associated with agricultural systems as well as food system sustainability. PMID:26308552

A portable analyser for the measurement of ammonium in marine waters.

PubMed

Amornthammarong, Natchanon; Zhang, Jia-Zhong; Ortner, Peter B; Stamates, Jack; Shoemaker, Michael; Kindel, Michael W

2013-03-01

A portable ammonium analyser was developed and used to measure in situ ammonium in the marine environment. The analyser incorporates an improved LED photodiode-based fluorescence detector (LPFD). This system is more sensitive and considerably smaller than previous systems and incorporates a pre-filtering subsystem enabling measurements in turbid, sediment-laden waters. Over the typical range for ammonium in marine waters (0–10 mM), the response is linear (r(2) = 0.9930) with a limit of detection (S/N ratio > 3) of 10 nM. The working range for marine waters is 0.05–10 mM. Repeatability is 0.3% (n =10) at an ammonium level of 2 mM. Results from automated operation in 15 min cycles over 16 days had good overall precision (RSD = 3%, n = 660). The system was field tested at three shallow South Florida sites. Diurnal cycles and possibly a tidal influence were expressed in the concentration variability observed.

Space station definition and preliminary design, WP-01. Volume 2: Results

NASA Technical Reports Server (NTRS)

Lenda, J. A.

1987-01-01

The basis for the studies and analyses which led to the results and conclusions documented and summarized, was the Engineering Master Schedule (EMS) generated by NASA and used as the controlling set of milestones and associated activities required to produce in a timely manner those products needed by all program participants in the establishment of an approved program baseline. The EMS consisted of twenty themes grouped into categories covering requirements, configurations, and strategies. A number of studies and analyses that were coordinated with the MSFC program and technical personnel as being needed to provide the requisite back-up material to satify the EMS were identified. These studies and analyses provided the data sufficient to support the conclusions and recommendations given to the MSFC in response to their EMS activity and to support the system level and conceptual design level approaches developed and reflected in the detailed sections of this document.

Development and validation of a rapid multi-class method for the confirmation of fourteen prohibited medicinal additives in pig and poultry compound feed by liquid chromatography-tandem mass spectrometry.

PubMed

Cronly, Mark; Behan, P; Foley, B; Malone, E; Earley, S; Gallagher, M; Shearan, P; Regan, L

2010-12-01

A confirmatory method has been developed to allow for the analysis of fourteen prohibited medicinal additives in pig and poultry compound feed. These compounds are prohibited for use as feed additives although some are still authorised for use in medicated feed. Feed samples are extracted by acetonitrile with addition of sodium sulfate. The extracts undergo a hexane wash to aid with sample purification. The extracts are then evaporated to dryness and reconstituted in initial mobile phase. The samples undergo an ultracentrifugation step prior to injection onto the LC-MS/MS system and are analysed in a run time of 26 min. The LC-MS/MS system is run in MRM mode with both positive and negative electrospray ionisation. The method was validated over three days and is capable of quantitatively analysing for metronidazole, dimetridazole, ronidazole, ipronidazole, chloramphenicol, sulfamethazine, dinitolimide, ethopabate, carbadox and clopidol. The method is also capable of qualitatively analysing for sulfadiazine, tylosin, virginiamycin and avilamycin. A level of 100 microg kg(-1) was used for validation purposes and the method is capable of analysing to this level for all the compounds. Validation criteria of trueness, precision, repeatability and reproducibility along with measurement uncertainty are calculated for all analytes. Copyright (c) 2010 Elsevier B.V. All rights reserved.

[Model-based biofuels system analysis: a review].

PubMed

Chang, Shiyan; Zhang, Xiliang; Zhao, Lili; Ou, Xunmin

2011-03-01

Model-based system analysis is an important tool for evaluating the potential and impacts of biofuels, and for drafting biofuels technology roadmaps and targets. The broad reach of the biofuels supply chain requires that biofuels system analyses span a range of disciplines, including agriculture/forestry, energy, economics, and the environment. Here we reviewed various models developed for or applied to modeling biofuels, and presented a critical analysis of Agriculture/Forestry System Models, Energy System Models, Integrated Assessment Models, Micro-level Cost, Energy and Emission Calculation Models, and Specific Macro-level Biofuel Models. We focused on the models' strengths, weaknesses, and applicability, facilitating the selection of a suitable type of model for specific issues. Such an analysis was a prerequisite for future biofuels system modeling, and represented a valuable resource for researchers and policy makers.

[A new approach to clinical and laboratory diagnosis of systemic and local soft tissue infections].

PubMed

Barkhatova, N A

2009-01-01

Dynamic measurements of blood TNF-a, IL-IRA, CRP, oligopeptide, and lactoferrin levels in patients with systemic and local soft tissue infections revealed direct correlation between them which allowed to use these indicators for the diagnosis of systemic infections. Results of clinical and laboratory analyses provided a basis for distinguishing short-term systemic inflammatory response syndrome and sepsis and developing relevant diagnostic criteria. Sepsis combined with systemic inflammatory response syndrome persisting for more than 72 hours after the onset of adequate therapy was characterized by CRP levels > 30 mg/l, oligopeptides > 0.34 U, lactoferrin > 1900 ng/ml, TNF-a > 6 pg/ml, ILL-IRA < 1500 pg/ml Patients with systemic inflammatory response syndrome for less than 72 hours had lower TNF-a, CRP, oligopeptide, and lactoferrin levels with IL-IRA > 1500 pg/ml. This new approach to early diagnosis of systemic infections makes it possible to optimize their treatment and thereby enhance its efficiency.

The Influence of Leadership in Implementing Management Systems

NASA Astrophysics Data System (ADS)

Nae, Ilie; Solomon, Gheorghe; Severin, Irina

2014-12-01

This paper presents a new perspective of the implementation of Management Systems within organizations in order to increase the success rate. The objective is to analyse how the leadership could influence positively or negatively the implementation, according to the leadership approach chosen. It offers a method to analyse the maturity of the leadership for any organization, based on existing leadership models, completing these models with specificities of a Management System. The Maturity Grid is extended to key elements of the Organizational Leadership: Strategic Planning, Process and Performance. The results expected are to change the current understanding of leadership during a Management System implementation(leadership seen as a principle) to an active leadership, implemented at organizational level. It propose an alternative of the classic management approach, to a Performance Management approach, that integrates naturally the leadership in all processes and methods

Fronts and frontogenesis as revealed by high time resolution data

NASA Technical Reports Server (NTRS)

Frank, A. E.; Barber, D. A.

1977-01-01

Upper air sounding are used to examine a cold front of average intensity. Vertical cross sections of potential temperature and wind, and horizontal analyses were compared and adjusted for consistency. These analyses were then used to study the evolution of the front, found to consist of a complex system of fronts occurring at all levels of the troposphere. Low level fronts were strongest at the surface and rapidly weakened with height. Fronts in the midddle troposphere were much more intense. The warm air ahead of the fronts was nearly barotropic, while the cold air behind was baroclinic through deep layers. A deep mixed layer was observed to grow in this cold air.

Development of datamining software for the city water supply company

NASA Astrophysics Data System (ADS)

Orlinskaya, O. G.; Boiko, E. V.

2018-05-01

The article considers issues of datamining software development for city water supply enterprises. Main stages of OLAP and datamining systems development are proposed. The system will allow water supply companies analyse accumulated data. Accordingly, improving the quality of data analysis would improve the manageability of the company and help to make the right managerial decisions by executives of various levels.

A global "imaging'' view on systems approaches in immunology.

PubMed

Ludewig, Burkhard; Stein, Jens V; Sharpe, James; Cervantes-Barragan, Luisa; Thiel, Volker; Bocharov, Gennady

2012-12-01

The immune system exhibits an enormous complexity. High throughput methods such as the "-omic'' technologies generate vast amounts of data that facilitate dissection of immunological processes at ever finer resolution. Using high-resolution data-driven systems analysis, causal relationships between complex molecular processes and particular immunological phenotypes can be constructed. However, processes in tissues, organs, and the organism itself (so-called higher level processes) also control and regulate the molecular (lower level) processes. Reverse systems engineering approaches, which focus on the examination of the structure, dynamics and control of the immune system, can help to understand the construction principles of the immune system. Such integrative mechanistic models can properly describe, explain, and predict the behavior of the immune system in health and disease by combining both higher and lower level processes. Moving from molecular and cellular levels to a multiscale systems understanding requires the development of methodologies that integrate data from different biological levels into multiscale mechanistic models. In particular, 3D imaging techniques and 4D modeling of the spatiotemporal dynamics of immune processes within lymphoid tissues are central for such integrative approaches. Both dynamic and global organ imaging technologies will be instrumental in facilitating comprehensive multiscale systems immunology analyses as discussed in this review. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Techno-Economic Assessment of Hybrid Cooling Systems for Coal- and Natural-Gas-Fired Power Plants with and without Carbon Capture and Storage.

PubMed

Zhai, Haibo; Rubin, Edward S

2016-04-05

Advanced cooling systems can be deployed to enhance the resilience of thermoelectric power generation systems. This study developed and applied a new power plant modeling option for a hybrid cooling system at coal- or natural-gas-fired power plants with and without amine-based carbon capture and storage (CCS) systems. The results of the plant-level analyses show that the performance and cost of hybrid cooling systems are affected by a range of environmental, technical, and economic parameters. In general, when hot periods last the entire summer, the wet unit of a hybrid cooling system needs to share about 30% of the total plant cooling load in order to minimize the overall system cost. CCS deployment can lead to a significant increase in the water use of hybrid cooling systems, depending on the level of CO2 capture. Compared to wet cooling systems, widespread applications of hybrid cooling systems can substantially reduce water use in the electric power sector with only a moderate increase in the plant-level cost of electricity generation.

Automation and robotics human performance

NASA Technical Reports Server (NTRS)

Mah, Robert W.

1990-01-01

The scope of this report is limited to the following: (1) assessing the feasibility of the assumptions for crew productivity during the intra-vehicular activities and extra-vehicular activities; (2) estimating the appropriate level of automation and robotics to accomplish balanced man-machine, cost-effective operations in space; (3) identifying areas where conceptually different approaches to the use of people and machines can leverage the benefits of the scenarios; and (4) recommending modifications to scenarios or developing new scenarios that will improve the expected benefits. The FY89 special assessments are grouped into the five categories shown in the report. The high level system analyses for Automation & Robotics (A&R) and Human Performance (HP) were performed under the Case Studies Technology Assessment category, whereas the detailed analyses for the critical systems and high leverage development areas were performed under the appropriate operations categories (In-Space Vehicle Operations or Planetary Surface Operations). The analysis activities planned for the Science Operations technology areas were deferred to FY90 studies. The remaining activities such as analytic tool development, graphics/video demonstrations and intelligent communicating systems software architecture were performed under the Simulation & Validations category.

Detection of heavy metals in water in Negeri Sembilan, Malaysia: From source to consumption

NASA Astrophysics Data System (ADS)

Khalaf, Baydaa; Abdullah, Md. Pauzi; Tahrim, Nurfaizah Abu

2018-04-01

Drinking water should be free from harmful levels of impurities, such as heavy metals. The aim of this study is to investigate the heavy metals concentrations in a water reticulation system of Negeri Sembilan. 25 stations were selected along Sungai Linggi (upstream of intake point) and through there reticulation system of Sungai Linggi Water Treatment Plant encompassing raw water through to the last point of use. Sampling activities were carried out in June and July 2016. The samples taken were analysed for heavymetals using an Inductively Coupled Plasma - Optical Emission Spectrometer (ICP-OES). In addition other water quality parameters were measured in situ (pH, water temperature, conductivity and dissolved oxygen) and analysed in the laboratory (BOD, COD, TSS, NH3-N, TOC and residual chlorine). The results showed a high level of Ca in the distribution system, while in the treatment plant it was normal, as well as Fe is decreased. Meanwhile Mn is decreased after treatment processes. The concentrations of DO and temperature in the tap water exceeded the standard concentrations.

Implementing evidence-based practice in community mental health agencies: a multiple stakeholder analysis.

PubMed

Aarons, Gregory A; Wells, Rebecca S; Zagursky, Karen; Fettes, Danielle L; Palinkas, Lawrence A

2009-11-01

We sought to identify factors believed to facilitate or hinder evidence-based practice (EBP) implementation in public mental health service systems as a step in developing theory to be tested in future studies. Focusing across levels of an entire large public sector mental health service system for youths, we engaged participants from 6 stakeholder groups: county officials, agency directors, program managers, clinical staff, administrative staff, and consumers. Participants generated 105 unique statements identifying implementation barriers and facilitators. Participants rated each statement on importance and changeability (i.e., the degree to which each barrier or facilitator is considered changeable). Data analyses distilled statements into 14 factors or dimensions. Descriptive analyses suggest that perceptions of importance and changeability varied across stakeholder groups. Implementation of EBP is a complex process. Cross-system-level approaches are needed to bring divergent and convergent perspectives to light. Examples include agency and program directors facilitating EBP implementation by supporting staff, actively sharing information with policymakers and administrators about EBP effectiveness and fit with clients' needs and preferences, and helping clinicians to present and deliver EBPs and address consumer concerns.

Dissipative open systems theory as a foundation for the thermodynamics of linear systems.

PubMed

Delvenne, Jean-Charles; Sandberg, Henrik

2017-03-06

In this paper, we advocate the use of open dynamical systems, i.e. systems sharing input and output variables with their environment, and the dissipativity theory initiated by Jan Willems as models of thermodynamical systems, at the microscopic and macroscopic level alike. We take linear systems as a study case, where we show how to derive a global Lyapunov function to analyse networks of interconnected systems. We define a suitable notion of dynamic non-equilibrium temperature that allows us to derive a discrete Fourier law ruling the exchange of heat between lumped, discrete-space systems, enriched with the Maxwell-Cattaneo correction. We complete these results by a brief recall of the steps that allow complete derivation of the dissipation and fluctuation in macroscopic systems (i.e. at the level of probability distributions) from lossless and deterministic systems.This article is part of the themed issue 'Horizons of cybernetical physics'. © 2017 The Author(s).

An inorganic carbon transport system responsible for acclimation specific to air levels of CO2 in Chlamydomonas reinhardtii.

PubMed

Wang, Yingjun; Spalding, Martin H

2006-06-27

Many photosynthetic microorganisms acclimate to CO(2) limited environments by induction and operation of CO(2)-concentrating mechanisms (CCMs). Despite their central role in CCM function, inorganic carbon (Ci) transport systems never have been identified in eukaryotic photosynthetic organisms. In the green alga Chlamydomonas reinhardtii, a mutant, pmp1, was described in 1983 with deficiencies in Ci transport, and a Pmp1 protein-associated Ci uptake system has been proposed to be responsible for Ci uptake in low CO(2) (air level)-acclimated cells. However, even though pmp1 represents the only clear genetic link to Ci transport in microalgae and is one of only a very few mutants directly affecting the CCM itself, the identity of Pmp1 has remained unknown. Physiological analyses indicate that C. reinhardtii possesses multiple Ci transport systems responsible for acclimation to different levels of limiting CO(2) and that the Pmp1-associated transport system is required specifically for low (air level) CO(2) acclimation. In the current study, we identified and characterized a pmp1 allelic mutant, air dier 1 (ad1) that, like pmp1, cannot grow in low CO(2) (350 ppm) but can grow either in high CO(2) (5% CO(2)) or in very low CO(2) (<200 ppm). Molecular analyses revealed that the Ad1/Pmp1 protein is encoded by LciB, a gene previously identified as a CO(2)-responsive gene. LciB and three related genes in C. reinhardtii compose a unique gene family that encode four closely related, apparently soluble plastid proteins with no clearly identifiable conserved motifs.

Prokaryotic regulatory systems biology: Common principles governing the functional architectures of Bacillus subtilis and Escherichia coli unveiled by the natural decomposition approach.

PubMed

Freyre-González, Julio A; Treviño-Quintanilla, Luis G; Valtierra-Gutiérrez, Ilse A; Gutiérrez-Ríos, Rosa María; Alonso-Pavón, José A

2012-10-31

Escherichia coli and Bacillus subtilis are two of the best-studied prokaryotic model organisms. Previous analyses of their transcriptional regulatory networks have shown that they exhibit high plasticity during evolution and suggested that both converge to scale-free-like structures. Nevertheless, beyond this suggestion, no analyses have been carried out to identify the common systems-level components and principles governing these organisms. Here we show that these two phylogenetically distant organisms follow a set of common novel biologically consistent systems principles revealed by the mathematically and biologically founded natural decomposition approach. The discovered common functional architecture is a diamond-shaped, matryoshka-like, three-layer (coordination, processing, and integration) hierarchy exhibiting feedback, which is shaped by four systems-level components: global transcription factors (global TFs), locally autonomous modules, basal machinery and intermodular genes. The first mathematical criterion to identify global TFs, the κ-value, was reassessed on B. subtilis and confirmed its high predictive power by identifying all the previously reported, plus three potential, master regulators and eight sigma factors. The functionally conserved cores of modules, basal cell machinery, and a set of non-orthologous common physiological global responses were identified via both orthologous genes and non-orthologous conserved functions. This study reveals novel common systems principles maintained between two phylogenetically distant organisms and provides a comparison of their lifestyle adaptations. Our results shed new light on the systems-level principles and the fundamental functions required by bacteria to sustain life. Copyright © 2012 Elsevier B.V. All rights reserved.

Integrated data analysis for genome-wide research.

PubMed

Steinfath, Matthias; Repsilber, Dirk; Scholz, Matthias; Walther, Dirk; Selbig, Joachim

2007-01-01

Integrated data analysis is introduced as the intermediate level of a systems biology approach to analyse different 'omics' datasets, i.e., genome-wide measurements of transcripts, protein levels or protein-protein interactions, and metabolite levels aiming at generating a coherent understanding of biological function. In this chapter we focus on different methods of correlation analyses ranging from simple pairwise correlation to kernel canonical correlation which were recently applied in molecular biology. Several examples are presented to illustrate their application. The input data for this analysis frequently originate from different experimental platforms. Therefore, preprocessing steps such as data normalisation and missing value estimation are inherent to this approach. The corresponding procedures, potential pitfalls and biases, and available software solutions are reviewed. The multiplicity of observations obtained in omics-profiling experiments necessitates the application of multiple testing correction techniques.

Analyzing endocrine system conservation and evolution.

PubMed

Bonett, Ronald M

2016-08-01

Analyzing variation in rates of evolution can provide important insights into the factors that constrain trait evolution, as well as those that promote diversification. Metazoan endocrine systems exhibit apparent variation in evolutionary rates of their constituent components at multiple levels, yet relatively few studies have quantified these patterns and analyzed them in a phylogenetic context. This may be in part due to historical and current data limitations for many endocrine components and taxonomic groups. However, recent technological advancements such as high-throughput sequencing provide the opportunity to collect large-scale comparative data sets for even non-model species. Such ventures will produce a fertile data landscape for evolutionary analyses of nucleic acid and amino acid based endocrine components. Here I summarize evolutionary rate analyses that can be applied to categorical and continuous endocrine traits, and also those for nucleic acid and protein-based components. I emphasize analyses that could be used to test whether other variables (e.g., ecology, ontogenetic timing of expression, etc.) are related to patterns of rate variation and endocrine component diversification. The application of phylogenetic-based rate analyses to comparative endocrine data will greatly enhance our understanding of the factors that have shaped endocrine system evolution. Copyright © 2016 Elsevier Inc. All rights reserved.

Multi-level analysis in information systems research: the case of enterprise resource planning system usage in China

NASA Astrophysics Data System (ADS)

Sun, Yuan; Bhattacherjee, Anol

2011-11-01

Information technology (IT) usage within organisations is a multi-level phenomenon that is influenced by individual-level and organisational-level variables. Yet, current theories, such as the unified theory of acceptance and use of technology, describe IT usage as solely an individual-level phenomenon. This article postulates a model of organisational IT usage that integrates salient organisational-level variables such as user training, top management support and technical support within an individual-level model to postulate a multi-level model of IT usage. The multi-level model was then empirically validated using multi-level data collected from 128 end users and 26 managers in 26 firms in China regarding their use of enterprise resource planning systems and analysed using the multi-level structural equation modelling (MSEM) technique. We demonstrate the utility of MSEM analysis of multi-level data relative to the more common structural equation modelling analysis of single-level data and show how single-level data can be aggregated to approximate multi-level analysis when multi-level data collection is not possible. We hope that this article will motivate future scholars to employ multi-level data and multi-level analysis for understanding organisational phenomena that are truly multi-level in nature.

The impact of contracting-out on health system performance: a conceptual framework.

PubMed

Liu, Xingzhu; Hotchkiss, David R; Bose, Sujata

2007-07-01

Despite the increased popularity of contracting-out of health services in developing countries, its effectiveness on overall health system performance is not yet conclusive. Except for substantial evidence of contracting-out's positive effect on access to health services and some evidence on improved equity in access, there is little evidence of contracting-out's impact on quality and efficiency. Most studies on the subject evaluate specific contracting-out projects against narrowly specified project objectives, not against more broadly defined health system goals. For this reason, conclusions of positive effects pertaining to project level may not hold at system level. This paper presents a conceptual framework that is expected to facilitate comprehensive, rigorous, and standardized evaluation of contracting-out at health system level. Specifically, this framework supports: full and standardized description of contracting-out interventions, study of the determinants of effectiveness, examination of provider and purchaser responses, assessment of the impact of contracting-out on all dimensions of health system performance, and cross-project analyses.

Formation and reduction of carcinogenic furan in various model systems containing food additives.

PubMed

Kim, Jin-Sil; Her, Jae-Young; Lee, Kwang-Geun

2015-12-15

The aim of this study was to analyse and reduce furan in various model systems. Furan model systems consisting of monosaccharides (0.5M glucose and ribose), amino acids (0.5M alanine and serine) and/or 1.0M ascorbic acid were heated at 121°C for 25 min. The effects of food additives (each 0.1M) such as metal ions (iron sulphate, magnesium sulphate, zinc sulphate and calcium sulphate), antioxidants (BHT and BHA), and sodium sulphite on the formation of furan were measured. The level of furan formed in the model systems was 6.8-527.3 ng/ml. The level of furan in the model systems of glucose/serine and glucose/alanine increased 7-674% when food additives were added. In contrast, the level of furan decreased by 18-51% in the Maillard reaction model systems that included ribose and alanine/serine with food additives except zinc sulphate. Copyright © 2014 Elsevier Ltd. All rights reserved.

Preliminary post-emplacement safety analysis of the subseabed disposal of high-level nuclear waste

NASA Astrophysics Data System (ADS)

Kaplan, M. F.; Koplik, C. M.; Klett, R. D.

1984-09-01

The radiological hazard from the disposal of high-level nuclear waste within the deep ocean sediments is evaluated, on a preliminary basis, for locations in the central North Pacific and in the northwestern Atlantic. Radio-nuclide transport in the sediment and water column and by marine organisms is considered. Peak doses to an individual are approximately five orders of magnitude below background levels for both sites. Sensitivity analyses for most aspects of the post-emplacement systems models are included.

System Level RBDO for Military Ground Vehicles using High Performance Computing

DTIC Science & Technology

2008-01-01

platform. Only the analyses that required more than 24 processors were conducted on the Onyx 350 due to the limited number of processors on the...optimization constraints varied. The queues set the number of processors and number of finite element code licenses available to the analyses. sgi ONYX ...3900: unix 24 MIPS R16000 PROCESSORS 4 IR2 GRAPHICS PIPES 4 IR3 GRAPHICS PIPES 24 GBYTES MEMORY 36 GBYTES LOCAL DISK SPACE sgi ONYX 350: unix 32 MIPS

Measurement of electromagnetic fields generated by air traffic control radar systems with spectrum analysers.

PubMed

Barellini, A; Bogi, L; Licitra, G; Silvi, A M; Zari, A

2009-12-01

Air traffic control (ATC) primary radars are 'classical' radars that use echoes of radiofrequency (RF) pulses from aircraft to determine their position. High-power RF pulses radiated from radar antennas may produce high electromagnetic field levels in the surrounding area. Measurement of electromagnetic fields produced by RF-pulsed radar by means of a swept-tuned spectrum analyser are investigated here. Measurements have been carried out both in the laboratory and in situ on signals generated by an ATC primary radar.

Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers.

PubMed

Bokhari, Syed Akhtar H; Khan, Ayyaz A; Butt, Arshad K; Hanif, Mohammad; Izhar, Mateen; Tatakis, Dimitris N; Ashfaq, Mohammad

2014-11-01

Few studies have examined the relationship of individual periodontal parameters with individual systemic biomarkers. This study assessed the possible association between specific clinical parameters of periodontitis and systemic biomarkers of coronary heart disease risk in coronary heart disease patients with periodontitis. Angiographically proven coronary heart disease patients with periodontitis (n = 317), aged >30 years and without other systemic illness were examined. Periodontal clinical parameters of bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) and systemic levels of high-sensitivity C-reactive protein (CRP), fibrinogen (FIB) and white blood cells (WBC) were noted and analyzed to identify associations through linear and stepwise multiple regression analyses. Unadjusted linear regression showed significant associations between periodontal and systemic parameters; the strongest association (r = 0.629; p < 0.001) was found between BOP and CRP levels, the periodontal and systemic inflammation marker, respectively. Stepwise regression analysis models revealed that BOP was a predictor of systemic CRP levels (p < 0.0001). BOP was the only periodontal parameter significantly associated with each systemic parameter (CRP, FIB, and WBC). In coronary heart disease patients with periodontitis, BOP is strongly associated with systemic CRP levels; this association possibly reflects the potential significance of the local periodontal inflammatory burden for systemic inflammation. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The response of numerical weather prediction analysis systems to FGGE 2b data

NASA Technical Reports Server (NTRS)

Hollingsworth, A.; Lorenc, A.; Tracton, S.; Arpe, K.; Cats, G.; Uppala, S.; Kallberg, P.

1985-01-01

An intercomparison of analyses of the main PGGE Level IIb data set is presented with three advanced analysis systems. The aims of the work are to estimate the extent and magnitude of the differences between the analyses, to identify the reasons for the differences, and finally to estimate the significance of the differences. Extratropical analyses only are considered. Objective evaluations of analysis quality, such as fit to observations, statistics of analysis differences, and mean fields are discussed. In addition, substantial emphasis is placed on subjective evaluation of a series of case studies that were selected to illustrate the importance of different aspects of the analysis procedures, such as quality control, data selection, resolution, dynamical balance, and the role of the assimilating forecast model. In some cases, the forecast models are used as selective amplifiers of analysis differences to assist in deciding which analysis was more nearly correct in the treatment of particular data.

Comparative analyses of different variants of standard ground for automatic control systems of technical processes of oil and gas production

NASA Astrophysics Data System (ADS)

Gromakov, E. I.; Gazizov, A. T.; Lukin, V. P.; Chimrov, A. V.

2017-01-01

The paper analyses efficiency (interference resistance) of standard TT, TN, IT networks in control links of automatic control systems (ACS) of technical processes (TP) of oil and gas production. Electromagnetic compatibility (EMC) is a standard term used to describe the interference in grounding circuits. Improved EMC of ACS TP can significantly reduce risks and costs of malfunction of equipment that could have serious consequences. It has been proved that an IT network is the best type of grounds for protection of ACS TP in real life conditions. It allows reducing the interference down to the level that is stated in standards of oil and gas companies.

Reproducible analyses of microbial food for advanced life support systems

NASA Technical Reports Server (NTRS)

Petersen, Gene R.

1988-01-01

The use of yeasts in controlled ecological life support systems (CELSS) for microbial food regeneration in space required the accurate and reproducible analysis of intracellular carbohydrate and protein levels. The reproducible analysis of glycogen was a key element in estimating overall content of edibles in candidate yeast strains. Typical analytical methods for estimating glycogen in Saccharomyces were not found to be entirely aplicable to other candidate strains. Rigorous cell lysis coupled with acid/base fractionation followed by specific enzymatic glycogen analyses were required to obtain accurate results in two strains of Candida. A profile of edible fractions of these strains was then determined. The suitability of yeasts as food sources in CELSS food production processes is discussed.

Pediatric patient safety events during hospitalization: approaches to accounting for institution-level effects.

PubMed

Slonim, Anthony D; Marcin, James P; Turenne, Wendy; Hall, Matt; Joseph, Jill G

2007-12-01

To determine the rates, patient, and institutional characteristics associated with the occurrence of patient safety indicators (PSIs) in hospitalized children and the degree of statistical difference derived from using three approaches of controlling for institution level effects. Pediatric Health Information System Dataset consisting of all pediatric discharges (<21 years of age) from 34 academic, freestanding children's hospitals for calendar year 2003. The rates of PSIs were computed for all discharges. The patient and institutional characteristics associated with these PSIs were calculated. The analyses sequentially applied three increasingly conservative methods to control for the institution-level effects robust standard error estimation, a fixed effects model, and a random effects model. The degree of difference from a "base state," which excluded institution-level variables, and between the models was calculated. The effects of these analyses on the interpretation of the PSIs are presented. PSIs are relatively infrequent events in hospitalized children ranging from 0 per 10,000 (postoperative hip fracture) to 87 per 10,000 (postoperative respiratory failure). Significant variables associated PSIs included age (neonates), race (Caucasians), payor status (public insurance), severity of illness (extreme), and hospital size (>300 beds), which all had higher rates of PSIs than their reference groups in the bivariable logistic regression results. The three different approaches of adjusting for institution-level effects demonstrated that there were similarities in both the clinical and statistical significance across each of the models. Institution-level effects can be appropriately controlled for by using a variety of methods in the analyses of administrative data. Whenever possible, resource-conservative methods should be used in the analyses especially if clinical implications are minimal.

Equity in the Turkish Education System: A Multilevel Analysis of Social Background Influences on the Mathematics Performance of 15-Year-Old Students

ERIC Educational Resources Information Center

Özdemir, Caner

2016-01-01

This paper aims to discover the level of equity in the Turkish education system using maths outcomes of 15-year-old students in the Programme for International Student Assessment (PISA) exam. In order to do that, associations between various social background variables and student performance are analysed via multilevel models. Female pupils,…

The cybernetics of viability: an overview

NASA Astrophysics Data System (ADS)

Nechansky, Helmut

2011-10-01

A three-level approach to viability is developed, considering (1) living systems, (2) a niche, understood as the area within the reach of their actions, and (3) an environment. A systematic analysis of the interrelations between these levels shows that living systems emerge with matter/energy processing systems. These can add controller structures when producing excess energy. A three-sensor controller structure enables a living system to deal with unfavourable and scarce environments. Further evolution of these controller structures offers improved ways to act on niches. Maintaining niches in scarce environments can require technology or economy. So social systems emerge, which are understood as aggregates of living systems. Basic patterns of interactions within social systems are analysed. So the introduction of the notion of the niche into the discussion of viability allows us to explain phenomena ranging from properties of single living systems to societal organization.

Technical Adequacy of the easyCBM Primary-Level Reading Measures (Grades K-1), 2009-2010 Version. Technical Report #1003

ERIC Educational Resources Information Center

Lai, Cheng-Fei; Nese, Joseph F. T.; Jamgochian, Elisa M.; Alonzo, Julie; Tindal, Gerald

2010-01-01

In this technical report, we provide the results of a series of studies on the technical adequacy of the early reading measures available on the easyCBM[R] assessment system. The results from the two-level hierarchical linear growth model analyses suggest that the reliability of the slope estimates for the easyCBM[R] reading measures are strong,…

Engineering-Level Model Atmospheres for Titan and Neptune

NASA Technical Reports Server (NTRS)

Justus, C. G.; Duvall, Aleta; Johnson, D. L.

2003-01-01

Engineering-level atmospheric models for Titan and Neptune have been developed for use in NASA s systems analysis studies of aerocapture applications in missions to the outer planets. Analogous to highly successful Global Reference Atmospheric Models for Earth (GRAM, Justus et al., 2000) and Mars (Mars-GRAM, Justus and Johnson, 2001, Justus et al., 2002) the new models are called Titan-GRAM and Neptune-GRAM. Like GRAM and Mars-GRAM, an important feature of Titan-GRAM and Neptune-GRAM is their ability to simulate quasi-random perturbations for Monte- Carlo analyses in developing guidance, navigation and control algorithms, and for thermal systems design.

Dynamic and Static Shape Test/Analysis Correlation of a 10 Meter Quadrant Solar Sail

NASA Technical Reports Server (NTRS)

Taleghani, Barmac K.; Lively, Peter S.; Gaspar, James L.; Murphy, David M.; Trautt, Thomas A.

2005-01-01

This paper describes finite element analyses and correlation studies to predict deformations and vibration modes/frequencies of a 10-meter quadrant solar sail system. Thin film membranes and booms were analyzed at the component and system-level. The objective was to verify the design and structural responses of the sail system and to mature solar sail technology to a TRL 5. The focus of this paper is in test/analysis correlation.

Safety evaluation methodology for advanced coal extraction systems

NASA Technical Reports Server (NTRS)

Zimmerman, W. F.

1981-01-01

Qualitative and quantitative evaluation methods for coal extraction systems were developed. The analysis examines the soundness of the design, whether or not the major hazards have been eliminated or reduced, and how the reduction would be accomplished. The quantitative methodology establishes the approximate impact of hazards on injury levels. The results are weighted by peculiar geological elements, specialized safety training, peculiar mine environmental aspects, and reductions in labor force. The outcome is compared with injury level requirements based on similar, safer industries to get a measure of the new system's success in reducing injuries. This approach provides a more detailed and comprehensive analysis of hazards and their effects than existing safety analyses.

Market assessment overview

NASA Technical Reports Server (NTRS)

Habib-Agahi, H.

1981-01-01

Market assessment, refined with analysis disaggregated from a national level to the regional level and to specific market applications, resulted in more accurate and detailed market estimates. The development of an integrated set of computer simulations, coupled with refined market data, allowed progress in the ability to evaluate the worth of solar thermal parabolic dish systems. In-depth analyses of both electric and thermal market applications of these systems are described. The following market assessment studies were undertaken: (1) regional analysis of the near term market for parabolic dish systems; (2) potential early market estimate for electric applications; (3) potential early market estimate for industrial process heat/cogeneration applications; and (4) selection of thermal and electric application case studies for fiscal year 1981.

Further characterisation of the functional neuroanatomy associated with prosodic emotion decoding.

PubMed

Mitchell, Rachel L C

2013-06-01

Current models of prosodic emotion comprehension propose a three stage cognition mediated by temporal lobe auditory regions through to inferior and orbitofrontal regions. Cumulative evidence suggests that its mediation may be more flexible though, with a facility to respond in a graded manner based on the need for executive control. The location of this fine-tuning system is unclear, as is its similarity to the cognitive control system. In the current study, need for executive control was manipulated in a block-design functional MRI study by systematically altering the proportion of incongruent trials across time, i.e., trials for which participants identified prosodic emotions in the face of conflicting lexico-semantic emotion cues. Resultant Blood Oxygenation Level Dependent contrast data were analysed according to standard procedures using Statistical Parametric Mapping v8 (Ashburner et al., 2009). In the parametric analyses, superior (medial) frontal gyrus activity increased linearly with increased need for executive control. In the separate analyses of each level of incongruity, results suggested that the baseline prosodic emotion comprehension system was sufficient to deal with low proportions of incongruent trials, whereas a more widespread frontal lobe network was required for higher proportions. These results suggest an executive control system for prosodic emotion comprehension exists which has the capability to recruit superior (medial) frontal gyrus in a graded manner and other frontal regions once demand exceeds a certain threshold. The need to revise current models of prosodic emotion comprehension and add a fourth processing stage are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

Diatom-inferred hydrological changes and Holocene geomorphic transitioning of Africa's largest estuarine system, Lake St Lucia

NASA Astrophysics Data System (ADS)

Gomes, M.; Humphries, M. S.; Kirsten, K. L.; Green, A. N.; Finch, J. M.; de Lecea, A. M.

2017-06-01

The diverse lagoons and coastal lakes along the east coast of South Africa occupy incised valleys that were flooded during the rise and subsequent stabilisation of relative sea-level during the Holocene. Sedimentary deposits contained within these waterbodies provide an opportunity to investigate complex hydrological and sedimentological processes, and examine sea-level controls governing system geomorphic evolution. In this paper, we combine diatom and sulfur isotope analyses from two sediment cores extracted from the northern sub-basins of Lake St Lucia, a large shallow estuarine lake that is today largely isolated from direct ocean influence behind a Holocene-Pleistocene barrier complex. Analyses allow the reconstruction of hydrological changes associated with the geomorphic development of the system over the mid-to late Holocene. The sedimentary sequences indicate that St Lucia was a shallow, partially enclosed estuary/embayment dominated by strong tidal flows prior to ∼6200 cal. BP. Infilling was initiated when sea-level rise slowed and stabilised around present day levels, resulting in the accumulation of fine-grained sediment behind an emergent proto-barrier. Diatom assemblages, dominated by marine benthic and epiphytic species, reveal a system structured by marine water influx and characterised by marsh and tidal flat habitats until ∼4550 cal. BP. A shift in the biological community at ∼4550 cal. BP is linked to the development of a back-barrier water body that supported a brackish community. Marine planktonics and enrichments in δ34S suggest recurrent, large-scale barrier inundation events during this time, coincident with a mid-Holocene sea-level highstand. Periodic marine incursions associated with episodes of enhanced storminess and overwash remained prevalent until ∼1200 cal. BP, when further barrier construction ultimately isolated the northern basins from the ocean. This study provides the first reconstruction of the palaeohydrological environment at Lake St Lucia and highlights the long-term geomorphic controls that have shaped the recent evolution and natural dynamics of the system. Unlike most coastal lake systems, this system is particularly effective as an archive of geomorphological change. Systems driven by back-barrier modifications, such as Lake St Lucia, highlight how geomorphological changes driven by sediment-supply, climate and sea level can be distributed unevenly over several isolated back-barrier basins.

Cost-assessment Analysis of Local Vehicle Scrapping Facility

NASA Astrophysics Data System (ADS)

Grabowski, Lukasz; Gliniak, Maciej; Polek, Daria; Gruca, Maria

2017-12-01

The purpose of the paper was to analyse the costs of recycling vehicles at local vehicle scrapping facility. The article contains regulations concerning vehicle decommissioning, describes the types of recovery, vehicles recycling networks, analyses the structure of a disassembly station, as well as the financial and institutional system in charge of dealing with the recycling of vehicles in Poland. The authors present the number of scrapped vehicles at local recycling company and the level of achieved recovery and recycling. The research presented in the article shows financial situation of the vehicle scrapping industry. In addition, it has been observed that the number of subsidies are directly proportional to the number of scrapped vehicles, and achieved levels of recycling and recovery depends on the percentage of incomplete vehicles.

Characterising the development of the understanding of human body systems in high-school biology students - a longitudinal study

NASA Astrophysics Data System (ADS)

Snapir, Zohar; Eberbach, Catherine; Ben-Zvi-Assaraf, Orit; Hmelo-Silver, Cindy; Tripto, Jaklin

2017-10-01

Science education today has become increasingly focused on research into complex natural, social and technological systems. In this study, we examined the development of high-school biology students' systems understanding of the human body, in a three-year longitudinal study. The development of the students' system understanding was evaluated using the Components Mechanisms Phenomena (CMP) framework for conceptual representation. We coded and analysed the repertory grid personal constructs of 67 high-school biology students at 4 points throughout the study. Our data analysis builds on the assumption that systems understanding entails a perception of all the system categories, including structures within the system (its Components), specific processes and interactions at the macro and micro levels (Mechanisms), and the Phenomena that present the macro scale of processes and patterns within a system. Our findings suggest that as the learning process progressed, the systems understanding of our students became more advanced, moving forward within each of the major CMP categories. Moreover, there was an increase in the mechanism complexity presented by the students, manifested by more students describing mechanisms at the molecular level. Thus, the 'mechanism' category and the micro level are critical components that enable students to understand system-level phenomena such as homeostasis.

Glutamatergic system abnormalities in posttraumatic stress disorder.

PubMed

Nishi, Daisuke; Hashimoto, Kenji; Noguchi, Hiroko; Hamazaki, Kei; Hamazaki, Tomohito; Matsuoka, Yutaka

2015-12-01

Accumulating evidence suggests involvement of the glutamatergic system in the biological mechanisms of posttraumatic stress disorder (PTSD), but few studies have demonstrated an association between glutamatergic system abnormalities and PTSD diagnosis or severity. We aimed to examine whether abnormalities in serum glutamate and in the glutamine/glutamate ratio were associated with PTSD diagnosis and severity in severely injured patients at risk for PTSD and major depressive disorder (MDD). This is a nested case-control study in TPOP (Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid) trial. Diagnosis and severity of PTSD were assessed 3 months after the accidents using the Clinician-Administered PTSD Scale. The associations of glutamate levels and the glutamine/glutamate ratio with diagnosis and severity of PTSD and MDD were investigated by univariate and multiple linear regression analyses. Ninety-seven of 110 participants (88 %) completed assessments at 3 months. Serum glutamate levels were significantly higher for participants with full or partial PTSD than for participants without PTSD (p = 0.049) and for participants with MDD than for participants without MDD (p = 0.048). Multiple linear regression analyses showed serum glutamate levels were significantly positively associated with PTSD severity (p = 0.02) and MDD severity (p = 0.03). The glutamine/glutamate ratio was also significantly inversely associated with PTSD severity (p = 0.03), but not with MDD severity (p = 0.07). These findings suggest that the glutamatergic system may play a major role in the pathogenesis of PTSD and the need for new treatments targeting the glutamatergic system to be developed for PTSD.

The LHCb trigger and its upgrade

NASA Astrophysics Data System (ADS)

Dziurda, A.; LHCb Trigger Group

2016-07-01

The current LHCb trigger system consists of a hardware level, which reduces the LHC inelastic collision rate of 30 MHz, at which the entire detector is read out. In a second level, implemented in a farm of 20 k parallel-processing CPUs, the event rate is reduced to about 5 kHz. We review the performance of the LHCb trigger system during Run I of the LHC. Special attention is given to the use of multivariate analyses in the High Level Trigger. The major bottleneck for hadronic decays is the hardware trigger. LHCb plans a major upgrade of the detector and DAQ system in the LHC shutdown of 2018, enabling a purely software based trigger to process the full 30 MHz of inelastic collisions delivered by the LHC. We demonstrate that the planned architecture will be able to meet this challenge.

The Roles of Individual and Organizational Factors in Burnout among Community-Based Mental Health Service Providers

PubMed Central

Green, Amy E.; Albanese, Brian J.; Shapiro, Nicole M.; Aarons, Gregory A.

2014-01-01

Public sector mental health care providers are at high risk for burnout which negatively affects not only provider well-being but also the quality of services for clients and the functioning of organizations. This study examines the influence of demographics, work characteristic, and organizational variables on levels of burnout among child and adolescent mental health service providers operating within a public sector mental health service system. Additionally, given the dearth of research examining differences in burnout levels among mental health sub-disciplines (e.g., social work, psychology, marital and family therapy) and mental health programs (e.g., outpatient, day treatment, Wraparound, case management), analyses were conducted to compare levels of burnout among multiple mental health disciplines and program types. Surveys were completed by 285 providers across 49 mental health programs in a large urban public mental health system. Variables representing dimensions of organizational climate and transformational leadership accounted for the greatest amount of variance in provider reported burnout. Analyses demonstrated significantly lower levels of depersonalization among Wraparound providers compared to traditional case managers. Age was the only demographic variable related to burnout. Additionally, no significant effects were found for provider discipline or for agency tenure and caseload size. Results suggest the need to consider organizational development strategies aimed at creating more functional and less stressful climates and increasing levels of transformational leadership behaviors in order to reduce levels of burnout among clinicians working in public mental health settings for youth and families. PMID:24564442

The Institutional Effects of Incarceration: Spillovers From Criminal Justice to Health Care

PubMed Central

Schnittker, Jason; Uggen, Christopher; Shannon, Sarah Ks; Mcelrath, Suzy Maves

2015-01-01

Context This study examines the spillover effects of growth in state-level incarceration rates on the functioning and quality of the US health care system. Methods Our multilevel approach first explored cross-sectional individual-level data on health care behavior merged to aggregate state-level data regarding incarceration. We then conducted an entirely aggregate-level analysis to address between-state heterogeneity and trends over time in health care access and utilization. Findings We found that individuals residing in states with a larger number of former prison inmates have diminished access to care, less access to specialists, less trust in physicians, and less satisfaction with the care they receive. These spillover effects are deep in that they affect even those least likely to be personally affected by incarceration, including the insured, those over 50, women, non-Hispanic whites, and those with incomes far exceeding the federal poverty threshold. These patterns likely reflect the burden of uncompensated care among former inmates, who have both a greater than average need for care and higher than average levels of uninsurance. State-level analyses solidify these claims. Increases in the number of former inmates are associated simultaneously with increases in the percentage of uninsured within a state and increases in emergency room use per capita, both net of controls for between-state heterogeneity. Conclusions Our analyses establish an intersection between systems of care and corrections, linked by inadequate financial and administrative mechanisms for delivering services to former inmates. PMID:26350929

Effects of prevailing winds on turbidity of a shallow estuary.

PubMed

Cho, Hyun Jung

2007-06-01

Estuarine waters are generally more turbid than lakes or marine waters due to greater algal mass and continual re-suspension of sediments. The varying effects of diurnal and seasonal prevailing winds on the turbidity condition of a wind-dominated estuary were investigated by spatial and statistical analyses of wind direction, water level, turbidity, chlorophyll a, and PAR (Photosynthetically Active Radiation) collected in Lake Pontchartrain, Louisiana, USA. The prolonged prevailing winds were responsible for the long-term, large-scale turbidity pattern of the estuary, whereas the short-term changes in wind direction had differential effects on turbidity and water level in varying locations. There were temporal and spatial changes in the relationship between vertical light attenuation coefficient (Kd) and turbidity, which indicate difference in phytoplankton and color also affect Kd. This study demonstrates that the effect of wind on turbidity and water level on different shores can be identified through system-specific analyses of turbidity patterns.

Effects of Prevailing Winds on Turbidity of a Shallow Estuary

PubMed Central

Cho, Hyun Jung

2007-01-01

Estuarine waters are generally more turbid than lakes or marine waters due to greater algal mass and continual re-suspension of sediments. The varying effects of diurnal and seasonal prevailing winds on the turbidity condition of a wind-dominated estuary were investigated by spatial and statistical analyses of wind direction, water level, turbidity, chlorophyll a, and PAR (Photosynthetically Active Radiation) collected in Lake Pontchartrain, Louisiana, USA. The prolonged prevailing winds were responsible for the long-term, large-scale turbidity pattern of the estuary, whereas the short-term changes in wind direction had differential effects on turbidity and water level in varying locations. There were temporal and spatial changes in the relationship between vertical light attenuation coefficient (Kd) and turbidity, which indicate difference in phytoplankton and color also affect Kd. This study demonstrates that the effect of wind on turbidity and water level on different shores can be identified through system-specific analyses of turbidity patterns. PMID:17617683

Space Missions Trade Space Generation and Assessment Using JPL Rapid Mission Architecture (RMA) Team Approach

NASA Technical Reports Server (NTRS)

Moeller, Robert C.; Borden, Chester; Spilker, Thomas; Smythe, William; Lock, Robert

2011-01-01

The JPL Rapid Mission Architecture (RMA) capability is a novel collaborative team-based approach to generate new mission architectures, explore broad trade space options, and conduct architecture-level analyses. RMA studies address feasibility and identify best candidates to proceed to further detailed design studies. Development of RMA first began at JPL in 2007 and has evolved to address the need for rapid, effective early mission architectural development and trade space exploration as a precursor to traditional point design evaluations. The RMA approach integrates a small team of architecture-level experts (typically 6-10 people) to generate and explore a wide-ranging trade space of mission architectures driven by the mission science (or technology) objectives. Group brainstorming and trade space analyses are conducted at a higher level of assessment across multiple mission architectures and systems to enable rapid assessment of a set of diverse, innovative concepts. This paper describes the overall JPL RMA team, process, and high-level approach. Some illustrative results from previous JPL RMA studies are discussed.

Aquifer-System Compaction and Land Subsidence: Measurements, Analyses, and Simulations-the Holly Site, Edwards Air Force Base, Antelope Valley, California

USGS Publications Warehouse

Sneed, Michelle; Galloway, Devin L.

2000-01-01

Land subsidence resulting from ground-water-level declines has long been recognized as a problem in Antelope Valley, California. At Edwards Air Force Base (EAFB), ground-water extractions have caused more than 150 feet of water-level decline, resulting in nearly 4 feet of subsidence. Differential land subsidence has caused sinklike depressions and earth fissures and has accelerated erosion of the playa lakebed surface of Rogers Lake at EAFB, adversely affecting the runways on the lakebed which are used for landing aircraft such as the space shuttles. Since 1990, about 0.4 foot of aquifer-system compaction has been measured at a deep (840 feet) borehole extensometer (Holly site) at EAFB. More than 7 years of paired ground-water-level and aquifer-system compaction measurements made at the Holly site were analyzed for this study. Annually, seasonal water-level fluctuations correspond to steplike variations in aquifer-system compaction; summer water-level drawdowns are associated with larger rates of compaction, and winter water-level recoveries are associated with smaller rates of compaction. The absence of aquifer-system expansion during recovery is consistent with the delayed drainage and resultant delayed, or residual, compaction of thick aquitards. A numerical one-dimensional MODFLOW model of aquitard drainage was used to refine estimates of aquifer-system hydraulic parameters that control compaction and to predict potential future compaction at the Holly site. The analyses and simulations of aquifer-system compaction are based on established theories of aquitard drainage. Historical ground-water-level and land-subsidence data collected near the Holly site were used to constrain simulations of aquifer-system compaction and land subsidence at the site for the period 1908?90, and ground-water-level and aquifer- system compaction measurements collected at the Holly site were used to constrain the model for the period 1990?97. Model results indicate that two thick aqui- tards, which total 129 feet or about half the aggregate thickness of all the aquitards penetrated by the Holly boreholes, account for most (greater than 99 percent) of the compaction measured at the Holly site during the period 1990?97. The results of three scenarios of future water-level changes indicate that these two thick aquitards account for most of the future compaction. The results also indicate that if water levels decline to about 30 feet below the 1997 water levels an additional 1.7 feet of compaction may occur during the next 30 years. If water levels remain at 1997 levels, the model predicts that only 0.8 foot of compaction may occur during the same period, and even if water levels recover to about 30 feet above 1997 water levels, another 0.5 foot of compaction may occur in the next 30 years. In addition, only a portion of the compaction that ultimately will occur likely will occur within the next 30 years; therefore, the residual compaction and associated land subsidence attributed to slowly equilibrating aquitards is important to consider in the long-term management of land and water resources at EAFB.

Graphic-based musculoskeletal model for biomechanical analyses and animation.

PubMed

Chao, Edmund Y S

2003-04-01

The ability to combine physiology and engineering analyses with computer sciences has opened the door to the possibility of creating the 'Virtual Human' reality. This paper presents a broad foundation for a full-featured biomechanical simulator for the human musculoskeletal system physiology. This simulation technology unites the expertise in biomechanical analysis and graphic modeling to investigate joint and connective tissue mechanics at the structural level and to visualize the results in both static and animated forms together with the model. Adaptable anatomical models including prosthetic implants and fracture fixation devices and a robust computational infrastructure for static, kinematic, kinetic, and stress analyses under varying boundary and loading conditions are incorporated on a common platform, the VIMS (Virtual Interactive Musculoskeletal System). Within this software system, a manageable database containing long bone dimensions, connective tissue material properties and a library of skeletal joint system functional activities and loading conditions are also available and they can easily be modified, updated and expanded. Application software is also available to allow end-users to perform biomechanical analyses interactively. This paper details the design, capabilities, and features of the VIMS development at Johns Hopkins University, an effort possible only through academic and commercial collaborations. Examples using these models and the computational algorithms in a virtual laboratory environment are used to demonstrate the utility of this unique database and simulation technology. This integrated system will impact on medical education, basic research, device development and application, and clinical patient care related to musculoskeletal diseases, trauma, and rehabilitation.

The expression of APRIL in Sjogren's syndrome: aberrant expression of APRIL in the salivary gland.

PubMed

Vosters, Jelle L; Roescher, Nienke; Polling, Eline J; Illei, Gabor G; Tak, Paul P

2012-09-01

A proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF) are B-cell-related mediators and may play a role in the pathogenesis in SS. In this descriptive study we assessed the expression of APRIL and BAFF in the minor salivary gland and serum from SS patients. Paraffin-embedded minor salivary gland sections from SS patients, non-SS controls and healthy volunteers were analysed by immunohistochemistry. Digital image quantification was performed to evaluate the expression of BAFF, APRIL and transmembrane activator and CAML interactor. Furthermore, serum was analysed for soluble BAFF and APRIL levels by ELISA. All the data were also analysed for subjects with decreased and normal stimulated salivary flow independent of the classification. APRIL expression was lower in minor salivary gland biopsies from SS patients compared with healthy volunteers and to a lesser extent non-SS controls, whereas BAFF expression was similar in all groups. Soluble APRIL levels in serum were increased in SS patients and in subjects with decreased salivary flow independent of the classification. APRIL salivary gland tissue levels are decreased, suggesting that targeting this cytokine locally in the salivary glands would not benefit SS patients. Moreover, the discrepancy between local and systemic levels is striking and future research should assess this in more detail.

Program level evaluation of ASAP diagnosis, referral and rehabilitation efforts. Volume 3, Analysis of ASAP rehabilitation countermeasures effectiveness

DOT National Transportation Integrated Search

1976-09-01

The present report describes the client flow through rehabilitation systems of the 35 NHTSA funded Alcohol Safety Action Projects (ASAPs) during the 1972-1974 period of project operations, summarizes project initiated analyses of treatment program ef...

[Governance in Guatemalan municipal development councils: an analysis of actors and power relationships].

PubMed

Flores, Walter; Gómez-Sánchez, Ismael

2010-01-01

Decentralisation and other public policies have created public spaces for participation in most Latin-American countries where community representatives, together with municipal authorities and other public functionaries, decide on social investment plans, including health services and infrastructure. The municipal development council system constitutes such public space in Guatemala. This study analysed such system's governance in a sample of 6 rural municipalities. A descriptive design was used, applying qualitative and quantitative techniques to study three central categories: the strategic actors, the rules of the game and power asymmetry levels amongst actors. The findings revealed inconsistencies amongst the actors who had to participate according to the legal framework and those actors who actually did so in practice. Divergent interests were also identified for participating which affected the possibility of reaching consensus during decision-making. Analysing the rules of the game led to identifying formal and non-formal mechanisms favouring some actors' ability to influence decisions. Analysing power asymmetry levels led to identifying that community representatives had fewer power resources than institutional representatives (local government and other government organisations). Community representatives also face different barriers blocking their participation and perceive a lesser capacity to influence decision-making. Existing barriers and fewer power resources experienced by community representatives reduce their abilities to influence decision-making in municipal development councils.

The association between attributions of responsibility for motor vehicle accidents and patient satisfaction: a study within a no-fault injury compensation system.

PubMed

Thompson, Jason; Berk, Michael; O'Donnell, Meaghan; Stafford, Lesley; Nordfjaern, Trond

2015-05-01

This study set out to test the relationship between attributions of responsibility for motor vehicle accidents and satisfaction with personal injury compensation systems. The study analysed survey data from 1394 people injured in a motor vehicle accident who were compensated under a no-fault personal injury compensation system. Patients' ratings of satisfaction with the compensation system across five domains (resolves your issues, keeps you up-to-date, treats you as an individual, cares about you, and overall satisfaction) were analysed alongside patient attributions of responsibility for their accident (not responsible, partly responsible, totally responsible). Postaccident physical and mental health status, age, gender, and duration of compensation claim were controlled for in the analysis. A multivariate analysis of covariance indicated attributions of responsibility for accidents were significantly associated with levels of patient satisfaction across all five domains under study (F (10, 2084) = 3.7, p<0.001, η(2)  =0.02). Despite access to virtually indistinguishable services, patients who attributed responsibility for their accidents to others were significantly less satisfied with the injury compensation system than those who attributed responsibility to themselves. Satisfaction with no-fault motor vehicle injury compensation services are associated with patients' attributions of responsibility for their accident. Compensation systems and other rehabilitation services monitoring patient satisfaction should adjust for attributions of responsibility when assessing levels of patient satisfaction between time periods, services, or injured populations. Differences in levels of patient satisfaction observed between compensation or rehabilitation populations may reflect differences in attributions of responsibility for accidents rather than objective service quality. © The Author(s) 2014.

Validation of the REMA score for predicting mast cell clonality and systemic mastocytosis in patients with systemic mast cell activation symptoms.

PubMed

Alvarez-Twose, I; González-de-Olano, D; Sánchez-Muñoz, L; Matito, A; Jara-Acevedo, M; Teodosio, C; García-Montero, A; Morgado, J M; Orfao, A; Escribano, L

2012-01-01

A variable percentage of patients with systemic mast cell (MC) activation symptoms meet criteria for systemic mastocytosis (SM). We prospectively evaluated the clinical utility of the REMA score versus serum baseline tryptase (sBt) levels for predicting MC clonality and SM in 158 patients with systemic MC activation symptoms in the absence of mastocytosis in the skin (MIS). World Health Organization criteria for SM were applied in all cases. MC clonality was defined as the presence of KIT-mutated MC or by a clonal HUMARA test. The REMA score consisted of the assignment of positive or negative points as follows: male (+1), female (-1), sBt <15 μg/l (-1) or >25 μg/l (+2), presence (-2) or absence (+1) of pruritus, hives or angioedema and presence (+3) of presyncope or syncope. Efficiency of the REMA score for predicting MC clonality and SM was assessed by receiver operating characteristic (ROC) curve analyses and compared to those obtained by means of sBt levels alone. Molecular studies revealed the presence of clonal MC in 68/80 SM cases and in 11/78 patients who did not meet the criteria for SM. ROC curve analyses confirmed the greater sensitivity and a similar specificity of the REMA score versus sBt levels (84 vs. 59% and 74 vs. 70% for MC clonality and 87 vs. 62% and 73 vs. 71% for SM, respectively). Our results confirm the clinical utility of the REMA score to predict MC clonality and SM in patients suffering from systemic MC activation symptoms without MIS. Copyright © 2011 S. Karger AG, Basel.

The effect of inflation rate on the cost of medical waste management system

NASA Astrophysics Data System (ADS)

Jolanta Walery, Maria

2017-11-01

This paper describes the optimization study aimed to analyse the impact of the parameter describing the inflation rate on the cost of the system and its structure. The study was conducted on the example of the analysis of medical waste management system in north-eastern Poland, in the Podlaskie Province. The scope of operational research carried out under the optimization study was divided into two stages of optimization calculations with assumed technical and economic parameters of the system. In the first stage, the lowest cost of functioning of the analysed system was generated, whereas in the second one the influence of the input parameter of the system, i.e. the inflation rate on the economic efficiency index (E) and the spatial structure of the system was determined. With the assumed inflation rate in the range of 1.00 to 1.12, the highest cost of the system was achieved at the level of PLN 2022.20/t (increase of economic efficiency index E by ca. 27% in comparison with run 1, with inflation rate = 1.12).

The impact of GPX1 on the association of groundwater selenium and depression: a project FRONTIER study

PubMed Central

2013-01-01

Background Prior animal model and human-based studies have linked selenium concentrations to decreased risk for depression; however, this work has not focused on household groundwater levels or specific depressive symptoms. The current study evaluated the link between groundwater selenium levels and depression. We also sought to determine if a functional polymorphism in the glutathione peroxidase 1 (GPX1) gene impacted this link. Methods We used a cross-sectional design to analyze data from 585 participants (183 men and 402 women) from Project FRONTIER, a study of rural health in West Texas. Residential selenium concentrations were estimated using Geospatial Information System (GIS) analyses. Linear regression models were created using Geriatric Depression Scale (GDS-30) total and subfactor scores as outcome variables and selenium concentrations as predictor variables. Analyses were re-run after stratification of the sample on GPX1 Pro198Leu genotype (rs1050454). Results Selenium levels were significantly and negatively related to all GDS and subfactor scores accounting for up to 17% of the variance beyond covariates. Selenium was most strongly protective against depression among homozygous carriers of the C allele at the Pro198Leu polymorphism of the GPX1 gene. Analyses also point towards a gene-environmental interaction between selenium exposure and GPX1 polymorphism. Conclusion Our results support the link between groundwater selenium levels and decreased depression symptoms. These findings also highlight the need to consider the genetics of the glutathione peroxidase system when examining this relationship, as variation in the GPX1 gene is related to depression risk and significantly influences the protective impact of selenium, which is indicative of a gene-environment interaction. PMID:23289525

Modeling and Simulation of Metallurgical Process Based on Hybrid Petri Net

NASA Astrophysics Data System (ADS)

Ren, Yujuan; Bao, Hong

2016-11-01

In order to achieve the goals of energy saving and emission reduction of iron and steel enterprises, an increasing number of modeling and simulation technologies are used to research and analyse metallurgical production process. In this paper, the basic principle of Hybrid Petri net is used to model and analyse the Metallurgical Process. Firstly, the definition of Hybrid Petri Net System of Metallurgical Process (MPHPNS) and its modeling theory are proposed. Secondly, the model of MPHPNS based on material flow is constructed. The dynamic flow of materials and the real-time change of each technological state in metallurgical process are simulated vividly by using this model. The simulation process can implement interaction between the continuous event dynamic system and the discrete event dynamic system at the same level, and play a positive role in the production decision.

Monoaminc and metabolite levels in the cerebrospinal fluid of hibernating and euthermic marmots.

PubMed

Reid; Kilduff; Romero; Florant; Dement; Heller

1992-03-01

Cerebrospinal fluid from yellow-bellied marmots, Marmota flaviventris, was analysed for monoamine and monoamine metabolite content during euthermia and deep hibernation. Dopamine (DA) levels were decreased, while DA metabolite levels, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), were dramatically increased in hibernating marmots. Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5HIAA) levels were also greatly enhanced during hibernation while norepinephrine (NE) levels were only moderately increased. These findings demonstrate that cerebrospinal monoamine levels are dynamically altered during hibernation, such that DA versus 5-HT and NE levels undergo opposite changes. Therefore, these data indicate that DA, 5-HT and NE neuronal systems are differentially altered during hibernation in mammals.

Biofilm formation and control in a simulated spacecraft water system - Three year results

NASA Technical Reports Server (NTRS)

Schultz, John R.; Flanagan, David T.; Bruce, Rebekah J.; Mudgett, Paul D.; Carr, Sandra E.; Rutz, Jeffrey A.; Huls, M. H.; Sauer, Richard L.; Pierson, Duane L.

1992-01-01

Two simulated spacecraft water systems are being used to evaluate the effectiveness of iodine for controlling microbial contamination within such systems. An iodine concentration of about 2.0 mg/L is maintained in one system by passing ultrapure water through an iodinated ion exchange resin. Stainless steel coupons with electropolished and mechanically-polished sides are being used to monitor biofilm formation. Results after three years of operation show a single episode of significant bacterial growth in the iodinated system when the iodine level dropped to 1.9 mg/L. This growth was apparently controlled by replacing the iodinated ion exchange resin, thereby increasing the iodine level. The second batch of resin has remained effective in controlling microbial growth down to an iodine level of 1.0 mg/L. SEM indicates that the iodine has impeded but may have not completely eliminated the formation of biofilm. Metals analyses reveal some corrosion in the iodinated system after 3 years of continuous exposure. Significant microbial contamination has been present continuously in a parallel noniodinated system since the third week of operation.

Proteomic and Metabolomic Analyses of Leaf from Clematis terniflora DC. Exposed to High-Level Ultraviolet-B Irradiation with Dark Treatment.

PubMed

Yang, Bingxian; Wang, Xin; Gao, Cuixia; Chen, Meng; Guan, Qijie; Tian, Jingkui; Komatsu, Setsuko

2016-08-05

Clematis terniflora DC. has potential pharmaceutical value; on the contrary, high-level UV-B irradiation with dark treatment led to the accumulation of secondary metabolites. Metabolomic and proteomic analyses of leaf of C. terniflora were performed to investigate the systematic response mechanisms to high-level UV-B irradiation with dark treatment. Metabolites related to carbohydrates, fatty acids, and amino acids and/or proteins related to stress, cell wall, and amino acid metabolism were gradually increased in response to high-level UV-B irradiation with dark treatment. On the basis of cluster analysis and mapping of proteins related to amino acid metabolism, the abundances of S-adenosylmethionine synthetase and cysteine synthase as well as 1,1-diphenyl-2-picrylhydrazyl scavenging activity were gradually increased in response to high-level UV-B irradiation with dark treatment. Furthermore, the abundance of dihydrolipoyl dehydrogenase/glutamate dehydrogenase and the content of γ-aminobutyric acid were also increased following high-level UV-B irradiation with dark treatment. Taken together, these results suggest that high-level UV-B irradiation with dark treatment induces the activation of reactive oxygen species scavenging system and γ-aminobutyric acid shunt pathway in leaf of C. terniflora.

Virtual Interactive Musculoskeletal System (VIMS) in orthopaedic research, education and clinical patient care.

PubMed

Chao, Edmund Y S; Armiger, Robert S; Yoshida, Hiroaki; Lim, Jonathan; Haraguchi, Naoki

2007-03-08

The ability to combine physiology and engineering analyses with computer sciences has opened the door to the possibility of creating the "Virtual Human" reality. This paper presents a broad foundation for a full-featured biomechanical simulator for the human musculoskeletal system physiology. This simulation technology unites the expertise in biomechanical analysis and graphic modeling to investigate joint and connective tissue mechanics at the structural level and to visualize the results in both static and animated forms together with the model. Adaptable anatomical models including prosthetic implants and fracture fixation devices and a robust computational infrastructure for static, kinematic, kinetic, and stress analyses under varying boundary and loading conditions are incorporated on a common platform, the VIMS (Virtual Interactive Musculoskeletal System). Within this software system, a manageable database containing long bone dimensions, connective tissue material properties and a library of skeletal joint system functional activities and loading conditions are also available and they can easily be modified, updated and expanded. Application software is also available to allow end-users to perform biomechanical analyses interactively. Examples using these models and the computational algorithms in a virtual laboratory environment are used to demonstrate the utility of these unique database and simulation technology. This integrated system, model library and database will impact on orthopaedic education, basic research, device development and application, and clinical patient care related to musculoskeletal joint system reconstruction, trauma management, and rehabilitation.

Virtual interactive musculoskeletal system (VIMS) in orthopaedic research, education and clinical patient care

PubMed Central

Chao, Edmund YS; Armiger, Robert S; Yoshida, Hiroaki; Lim, Jonathan; Haraguchi, Naoki

2007-01-01

The ability to combine physiology and engineering analyses with computer sciences has opened the door to the possibility of creating the "Virtual Human" reality. This paper presents a broad foundation for a full-featured biomechanical simulator for the human musculoskeletal system physiology. This simulation technology unites the expertise in biomechanical analysis and graphic modeling to investigate joint and connective tissue mechanics at the structural level and to visualize the results in both static and animated forms together with the model. Adaptable anatomical models including prosthetic implants and fracture fixation devices and a robust computational infrastructure for static, kinematic, kinetic, and stress analyses under varying boundary and loading conditions are incorporated on a common platform, the VIMS (Virtual Interactive Musculoskeletal System). Within this software system, a manageable database containing long bone dimensions, connective tissue material properties and a library of skeletal joint system functional activities and loading conditions are also available and they can easily be modified, updated and expanded. Application software is also available to allow end-users to perform biomechanical analyses interactively. Examples using these models and the computational algorithms in a virtual laboratory environment are used to demonstrate the utility of these unique database and simulation technology. This integrated system, model library and database will impact on orthopaedic education, basic research, device development and application, and clinical patient care related to musculoskeletal joint system reconstruction, trauma management, and rehabilitation. PMID:17343764

Estimating mortality using data from civil registration: a cross-sectional study in India

PubMed Central

Rao, Chalapati; Lakshmi, PVM; Prinja, Shankar; Kumar, Rajesh

2016-01-01

Abstract Objective To analyse the design and operational status of India’s civil registration and vital statistics system and facilitate the system’s development into an accurate and reliable source of mortality data. Methods We assessed the national civil registration and vital statistics system’s legal framework, administrative structure and design through document review. We did a cross-sectional study for the year 2013 at national level and in Punjab state to assess the quality of the system’s mortality data through analyses of life tables and investigation of the completeness of death registration and the proportion of deaths assigned ill-defined causes. We interviewed registrars, medical officers and coders in Punjab state to assess their knowledge and practice. Findings Although we found the legal framework and system design to be appropriate, data collection was based on complex intersectoral collaborations at state and local level and the collected data were found to be of poor quality. The registration data were inadequate for a robust estimate of mortality at national level. A medically certified cause of death was only recorded for 965 992 (16.8%) of the 5 735 082 deaths registered. Conclusion The data recorded by India’s civil registration and vital statistics system in 2011 were incomplete. If improved, the system could be used to reliably estimate mortality. We recommend improving political support and intersectoral coordination, capacity building, computerization and state-level initiatives to ensure that every death is registered and that reliable causes of death are recorded – at least within an adequate sample of registration units within each state. PMID:26769992

Geovisualisation of relief in a virtual reality system on the basis of low-level aerial imagery

NASA Astrophysics Data System (ADS)

Halik, Łukasz; Smaczyński, Maciej

2017-12-01

The aim of the following paper was to present the geomatic process of transforming low-level aerial imagery obtained with unmanned aerial vehicles (UAV) into a digital terrain model (DTM) and implementing the model into a virtual reality system (VR). The object of the study was a natural aggretage heap of an irregular shape and denivelations up to 11 m. Based on the obtained photos, three point clouds (varying in the level of detail) were generated for the 20,000-m2-area. For further analyses, the researchers selected the point cloud with the best ratio of accuracy to output file size. This choice was made based on seven control points of the heap surveyed in the field and the corresponding points in the generated 3D model. The obtained several-centimetre differences between the control points in the field and the ones from the model might testify to the usefulness of the described algorithm for creating large-scale DTMs for engineering purposes. Finally, the chosen model was implemented into the VR system, which enables the most lifelike exploration of 3D terrain plasticity in real time, thanks to the first person view mode (FPV). In this mode, the user observes an object with the aid of a Head- mounted display (HMD), experiencing the geovisualisation from the inside, and virtually analysing the terrain as a direct animator of the observations.

Hospital drug and therapeutics committees in Australia: is there a role for economic evaluation at the institutional level?

PubMed

Gallego, Gisselle

2011-12-01

Decisions about spending on medicines occur at different levels in the Australian health care system. This commentary describes the role of economic evaluation at the institutional (public hospital) level. In contrast to the decisions taken at the level of Federal subsidy (listing on the Pharmaceutical Benefits Scheme) formal pharmacoeonomic data analyses are usually not available, and arguably often not relevant to decision making within the public hospital setting. Future research is needed to develop and explore models of best practice and how to incorporate pharmacoeconomic evidence into local decisions.

Using explanatory crop models to develop simple tools for Advanced Life Support system studies

NASA Technical Reports Server (NTRS)

Cavazzoni, J.

2004-01-01

System-level analyses for Advanced Life Support require mathematical models for various processes, such as for biomass production and waste management, which would ideally be integrated into overall system models. Explanatory models (also referred to as mechanistic or process models) would provide the basis for a more robust system model, as these would be based on an understanding of specific processes. However, implementing such models at the system level may not always be practicable because of their complexity. For the area of biomass production, explanatory models were used to generate parameters and multivariable polynomial equations for basic models that are suitable for estimating the direction and magnitude of daily changes in canopy gas-exchange, harvest index, and production scheduling for both nominal and off-nominal growing conditions. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

National Transonic Facility model and model support vibration problems

NASA Technical Reports Server (NTRS)

Young, Clarence P., Jr.; Popernack, Thomas G., Jr.; Gloss, Blair B.

1990-01-01

Vibrations of models and model support system were encountered during testing in the National Transonic Facility. Model support system yaw plane vibrations have resulted in model strain gage balance design load limits being reached. These high levels of vibrations resulted in limited aerodynamic testing for several wind tunnel models. The yaw vibration problem was the subject of an intensive experimental and analytical investigation which identified the primary source of the yaw excitation and resulted in attenuation of the yaw oscillations to acceptable levels. This paper presents the principal results of analyses and experimental investigation of the yaw plane vibration problems. Also, an overview of plans for development and installation of a permanent model system dynamic and aeroelastic response measurement and monitoring system for the National Transonic Facility is presented.

Advanced batteries for load-leveling - The utility perspective on system integration

NASA Astrophysics Data System (ADS)

Delmonaco, J. L.; Lewis, P. A.; Roman, H. T.; Zemkoski, J.

1982-09-01

Rechargeable battery systems for applications as utility load-leveling units, particularly in urban areas, are discussed. Particular attention is given to advanced lead-acid, zinc-halogen, sodium-sulfer, and lithium-iron sulfide battery systems, noting that battery charging can proceed at light load hours and requires no fuel on-site. Each battery site will have a master site controller and related subsystems necessary for ensuring grid-quality power output from the batteries and charging when feasible. The actual interconnection with the grid is envisioned as similar to transmission, subtransmission, or distribution systems similar to cogeneration or wind-derived energy interconnections. Analyses are presented of factors influencing the planning economics, impacts on existing grids through solid-state converters, and operational and maintenance considerations. Finally, research directions towards large scale battery implementation are outlined.

Earth Observatory Satellite system definition study. Report 3: Design cost trade-off studies and recommendations

NASA Technical Reports Server (NTRS)

1974-01-01

An analysis of the design and cost tradeoff aspects of the Earth Observatory Satellite (EOS) development is presented. The design/cost factors that affect a series of mission/system level concepts are discussed. The subjects considered are as follows: (1) spacecraft subsystem cost tradeoffs, (2) ground system cost tradeoffs, and (3) program cost summary. Tables of data are provided to summarize the results of the analyses. Illustrations of the various spacecraft configurations are included.

Tipping point analysis of ocean acoustic noise

NASA Astrophysics Data System (ADS)

Livina, Valerie N.; Brouwer, Albert; Harris, Peter; Wang, Lian; Sotirakopoulos, Kostas; Robinson, Stephen

2018-02-01

We apply tipping point analysis to a large record of ocean acoustic data to identify the main components of the acoustic dynamical system and study possible bifurcations and transitions of the system. The analysis is based on a statistical physics framework with stochastic modelling, where we represent the observed data as a composition of deterministic and stochastic components estimated from the data using time-series techniques. We analyse long-term and seasonal trends, system states and acoustic fluctuations to reconstruct a one-dimensional stochastic equation to approximate the acoustic dynamical system. We apply potential analysis to acoustic fluctuations and detect several changes in the system states in the past 14 years. These are most likely caused by climatic phenomena. We analyse trends in sound pressure level within different frequency bands and hypothesize a possible anthropogenic impact on the acoustic environment. The tipping point analysis framework provides insight into the structure of the acoustic data and helps identify its dynamic phenomena, correctly reproducing the probability distribution and scaling properties (power-law correlations) of the time series.

Technical and Economic Assessment of the Implementation of Measures for Reducing Energy Losses in Distribution Systems

NASA Astrophysics Data System (ADS)

Aguila, Alexander; Wilson, Jorge

2017-07-01

This paper develops a methodology to assess a group of measures of electrical improvements in distribution systems, starting from the complementation of technical and economic criteria. In order to solve the problem of energy losses in distribution systems, technical and economic analysis was performed based on a mathematical model to establish a direct relationship between the energy saved by way of minimized losses and the costs of implementing the proposed measures. This paper aims at analysing the feasibility of reducing energy losses in distribution systems, by changing existing network conductors by larger crosssection conductors and distribution voltage change at higher levels. The impact of this methodology provides a highly efficient mathematical tool for analysing the feasibility of implementing improvement projects based on their costs which is a very useful tool for the distribution companies that will serve as a starting point to the analysis for this type of projects in distribution systems.

Bidirectional Prospective Associations Between Cardiac Autonomic Activity and Inflammatory Markers.

PubMed

Hu, Mandy Xian; Lamers, Femke; Neijts, Melanie; Willemsen, Gonneke; de Geus, Eco J C; Penninx, Brenda W J H

2018-06-01

Autonomic nervous system (ANS) imbalance has been cross-sectionally associated with inflammatory processes. Longitudinal studies are needed to shed light on the nature of this relationship. We examined cross-sectional and bidirectional prospective associations between cardiac autonomic measures and inflammatory markers. Analyses were conducted with baseline (n = 2823), 2-year (n = 2099), and 6-year (n = 1774) data from the Netherlands Study of Depression and Anxiety. To compare the pattern of results, prospective analyses with ANS (during sleep, leisure time, and work) and inflammation were conducted in two data sets from the Netherlands Twin Register measured for 4.9 years (n = 356) and 5.4 years (n = 472). Autonomic nervous system measures were heart rate (HR) and respiratory sinus arrhythmia (RSA). Inflammatory markers were C-reactive protein (CRP) and interleukin (IL)-6. The Netherlands Study of Depression and Anxiety results showed that higher HR and lower RSA were cross-sectionally significantly associated with higher inflammatory levels. Higher HR predicted higher levels of CRP (B = .065, p < .001) and IL-6 (B = .036, p = .014) at follow-up. Higher CRP levels predicted lower RSA (B = -.024, p = .048) at follow-up. The Netherlands Twin Register results confirmed that higher HR was associated with higher CRP and IL-6 levels 4.9 years later. Higher IL-6 levels predicted higher HR and lower RSA at follow-up. Autonomic imbalance is associated with higher levels of inflammation. Independent data from two studies converge in evidence that higher HR predicts subsequent higher levels of CRP and IL-6. Inflammatory markers may also predict future ANS activity, but evidence for this was less consistent.

Referential communication abilities and Theory of Mind development in preschool children.

PubMed

Resches, Mariela; Pérez Pereira, Miguel

2007-02-01

This work aims to analyse the specific contribution of social abilities (here considered as the capacity for attributing knowledge to others) in a particular communicative context. 74 normally developing children (aged 3;4 to 5;9, M = 4.6) were given two Theory of Mind (ToM) tasks, which are considered to assess increasing complexity levels of epistemic state attribution: Attribution of knowledge-ignorance (Pillow, 1989; adapted by Welch-Ross, 1997) and Understanding of False-belief (Baron Cohen, Leslie & Frith, 1985). Subjects were paired according to their age and level of performance in ToM tasks. These dyads participated in a referential communication task specially designed for this research. The resulting communicative interchanges were analysed using a three-level category system (pragmatic functions, descriptive accuracy, and ambiguity of messages). The results showed significant differences among subjects with different levels of social comprehension regarding the type of communicative resources used by them in every category level. In particular, understanding of false belief seems to be the most powerful predictor of changes in the children's development of communicative competence.

System safety in Stirling engine development

NASA Technical Reports Server (NTRS)

Bankaitis, H.

1981-01-01

The DOE/NASA Stirling Engine Project Office has required that contractors make safety considerations an integral part of all phases of the Stirling engine development program. As an integral part of each engine design subtask, analyses are evolved to determine possible modes of failure. The accepted system safety analysis techniques (Fault Tree, FMEA, Hazards Analysis, etc.) are applied in various degrees of extent at the system, subsystem and component levels. The primary objectives are to identify critical failure areas, to enable removal of susceptibility to such failures or their effects from the system and to minimize risk.

Smart Grid Development: Multinational Demo Project Analysis

NASA Astrophysics Data System (ADS)

Oleinikova, I.; Mutule, A.; Obushevs, A.; Antoskovs, N.

2016-12-01

This paper analyses demand side management (DSM) projects and stakeholders' experience with the aim to develop, promote and adapt smart grid tehnologies in Latvia. The research aims at identifying possible system service posibilites, including demand response (DR) and determining the appropriate market design for such type of services to be implemented at the Baltic power system level, with the cooperation of distribution system operator (DSO) and transmission system operator (TSO). This paper is prepared as an extract from the global smart grid best practices, smart solutions and business models.

Seasonal changes in ground-water quality and ground-water levels and directions of ground-water movement in southern Elmore County, southwestern Idaho, including Mountain Home Air Force Base, 1990-1991

USGS Publications Warehouse

Young, H.W.; Parliman, D.J.; Jones, Michael L.

1992-01-01

The study area is located in southern Elmore County, southwestern Idaho, and includes the Mountain Home Air Force Base located approximately 10 mi southwest of the city of Mountain Home. Chemical analyzes have been made periodically since the late 1940's on water samples from supply wells on the Air Force Base. These analyses indicate increases in specific conductance and in concentrations of nitrogen compounds, chloride, and sulfate. The purposes of this report, which was prepared in cooperation with the Department of the Air Force, are to describe the seasonal changes in water quality and water levels and to depict the directions of ground-water movement in the regional aquifer system and perched-water zones. Although data presented in this report are from both the regional ground-water system and perched-water zones, the focus is on the regional system. A previous study by the U.S. Geological Survey (Parliman and Young, 1990) describes the areal changes in water quality and water levels during the fall of 1989. During March, July, and October 1990, 141 wells were inventoried and depth to water was measured. Continuous water-level recorders were installed on 5 of the wells and monthly measurements of depth to water were made in 17 of the wells during March 1990 through February 1991. Water samples from 33 wells and 1 spring were collected during the spring and fall of 1990 for chemical analyses. Samples also were collected monthly from 11 of those wells during April to September 1990 (table 1). Selected well-construction and water-use data and measurements of depth to water for 141 wells are given in table 2 (separated sheets in envelope). Directions of ground-water movement and selected hydrographs showing seasonal fluctuations of water levels in the regional ground-water system and perched-water zones are shown on sheet 2. Changes in water levels in the regional ground-water system during March to October 1990 are shown on sheet 2.

Sinabro: A Smartphone-Integrated Opportunistic Electrocardiogram Monitoring System

PubMed Central

Kwon, Sungjun; Lee, Dongseok; Kim, Jeehoon; Lee, Youngki; Kang, Seungwoo; Seo, Sangwon; Park, Kwangsuk

2016-01-01

In our preliminary study, we proposed a smartphone-integrated, unobtrusive electrocardiogram (ECG) monitoring system, Sinabro, which monitors a user’s ECG opportunistically during daily smartphone use without explicit user intervention. The proposed system also monitors ECG-derived features, such as heart rate (HR) and heart rate variability (HRV), to support the pervasive healthcare apps for smartphones based on the user’s high-level contexts, such as stress and affective state levels. In this study, we have extended the Sinabro system by: (1) upgrading the sensor device; (2) improving the feature extraction process; and (3) evaluating extensions of the system. We evaluated these extensions with a good set of algorithm parameters that were suggested based on empirical analyses. The results showed that the system could capture ECG reliably and extract highly accurate ECG-derived features with a reasonable rate of data drop during the user’s daily smartphone use. PMID:26978364

Sinabro: A Smartphone-Integrated Opportunistic Electrocardiogram Monitoring System.

PubMed

Kwon, Sungjun; Lee, Dongseok; Kim, Jeehoon; Lee, Youngki; Kang, Seungwoo; Seo, Sangwon; Park, Kwangsuk

2016-03-11

In our preliminary study, we proposed a smartphone-integrated, unobtrusive electrocardiogram (ECG) monitoring system, Sinabro, which monitors a user's ECG opportunistically during daily smartphone use without explicit user intervention. The proposed system also monitors ECG-derived features, such as heart rate (HR) and heart rate variability (HRV), to support the pervasive healthcare apps for smartphones based on the user's high-level contexts, such as stress and affective state levels. In this study, we have extended the Sinabro system by: (1) upgrading the sensor device; (2) improving the feature extraction process; and (3) evaluating extensions of the system. We evaluated these extensions with a good set of algorithm parameters that were suggested based on empirical analyses. The results showed that the system could capture ECG reliably and extract highly accurate ECG-derived features with a reasonable rate of data drop during the user's daily smartphone use.

Bayesian assessment of overtriage and undertriage at a level I trauma centre.

PubMed

DiDomenico, Paul B; Pietzsch, Jan B; Paté-Cornell, M Elisabeth

2008-07-13

We analysed the trauma triage system at a specific level I trauma centre to assess rates of over- and undertriage and to support recommendations for system improvements. The triage process is designed to estimate the severity of patient injury and allocate resources accordingly, with potential errors of overestimation (overtriage) consuming excess resources and underestimation (undertriage) potentially leading to medical errors.We first modelled the overall trauma system using risk analysis methods to understand interdependencies among the actions of the participants. We interviewed six experienced trauma surgeons to obtain their expert opinion of the over- and undertriage rates occurring in the trauma centre. We then assessed actual over- and undertriage rates in a random sample of 86 trauma cases collected over a six-week period at the same centre. We employed Bayesian analysis to quantitatively combine the data with the prior probabilities derived from expert opinion in order to obtain posterior distributions. The results were estimates of overtriage and undertriage in 16.1 and 4.9% of patients, respectively. This Bayesian approach, which provides a quantitative assessment of the error rates using both case data and expert opinion, provides a rational means of obtaining a best estimate of the system's performance. The overall approach that we describe in this paper can be employed more widely to analyse complex health care delivery systems, with the objective of reduced errors, patient risk and excess costs.

Jerky driving--An indicator of accident proneness?

PubMed

Bagdadi, Omar; Várhelyi, András

2011-07-01

This study uses continuously logged driving data from 166 private cars to derive the level of jerks caused by the drivers during everyday driving. The number of critical jerks found in the data is analysed and compared with the self-reported accident involvement of the drivers. The results show that the expected number of accidents for a driver increases with the number of critical jerks caused by the driver. Jerk analyses make it possible to identify safety critical driving behaviour or "accident prone" drivers. They also facilitate the development of safety measures such as active safety systems or advanced driver assistance systems, ADAS, which could be adapted for specific groups of drivers or specific risky driving behaviour. Copyright © 2011 Elsevier Ltd. All rights reserved.

An assessment of the microgravity and acoustic environments in Space Station Freedom using VAPEPS

NASA Technical Reports Server (NTRS)

Bergen, Thomas F.; Scharton, Terry D.; Badilla, Gloria A.

1992-01-01

The Vibroacoustic Payload Environment Prediction System (VAPEPS) was used to predict the stationary on-orbit environments in one of the Space Station Freedom modules. The model of the module included the outer structure, equipment and payload racks, avionics, and cabin air and duct systems. Acoustic and vibratory outputs of various source classes were derived and input to the model. Initial results of analyses, performed in one-third octave frequency bands from 10 to 10,000 Hz, show that both the microgravity and acoustic environments will be exceeded in some one-third octave bands with the current SSF design. Further analyses indicate that interior acoustic level requirements will be exceeded even if the microgravity requirements are met.

Institutional Consequences of Quality Assessment

ERIC Educational Resources Information Center

Joao Rosa, Maria; Tavares, Diana; Amaral, Alberto

2006-01-01

This paper analyses the opinions of Portuguese university rectors and academics on the quality assessment system and its consequences at the institutional level. The results obtained show that university staff (rectors and academics, with more of the former than the latter) held optimistic views of the positive consequences of quality assessment…

78 FR 17747 - Agency Information Collection Activities: Request for Comments for a New Information Collection.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-22

... define the types of analyses to be used to evaluate benefits, cost-effectiveness and feasibility...: Feasibility of Element-Level Bridge Inspection for Non- National Highway System Bridges. Background: The... a requirement for a study on the benefits, cost-effectiveness, and feasibility of requiring element...

Review of storage battery system cost estimates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, D.R.; Russell, J.A.

1986-04-01

Cost analyses for zinc bromine, sodium sulfur, and lead acid batteries were reviewed. Zinc bromine and sodium sulfur batteries were selected because of their advanced design nature and the high level of interest in these two technologies. Lead acid batteries were included to establish a baseline representative of a more mature technology.

Comparative, Population-Level Analysis of Social Networks in Organizations

ERIC Educational Resources Information Center

Jacobs, Abigail Z.

2017-01-01

As social behavior moves increasingly online, the study of social behavior has followed. Online traces of social systems, whether to study online behavior directly or the online traces of offline activity, have made possible previously unavailable empirical analyses of people, groups and organizations. However, practically observing any social…

Students' Understanding of Advanced Properties of Java Exceptions

ERIC Educational Resources Information Center

Rashkovits, Rami; Lavy, Ilana

2012-01-01

This study examines how Information Systems Engineering School students on the verge of their graduation understand the mechanism of exception handling. The main contributions of this paper are as follows: we construct a questionnaire aimed at examining students' level of understanding concerning exceptions; we classify and analyse the students'…

Single-cell analysis of population context advances RNAi screening at multiple levels

PubMed Central

Snijder, Berend; Sacher, Raphael; Rämö, Pauli; Liberali, Prisca; Mench, Karin; Wolfrum, Nina; Burleigh, Laura; Scott, Cameron C; Verheije, Monique H; Mercer, Jason; Moese, Stefan; Heger, Thomas; Theusner, Kristina; Jurgeit, Andreas; Lamparter, David; Balistreri, Giuseppe; Schelhaas, Mario; De Haan, Cornelis A M; Marjomäki, Varpu; Hyypiä, Timo; Rottier, Peter J M; Sodeik, Beate; Marsh, Mark; Gruenberg, Jean; Amara, Ali; Greber, Urs; Helenius, Ari; Pelkmans, Lucas

2012-01-01

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image-based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single-cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome-wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell-based screens at this depth reveals widespread RNAi-induced changes in the population context of individual cells leading to indirect RNAi effects, as well as perturbations of cell-to-cell variability regulators. We find that accounting for indirect effects improves the consistency between siRNAs targeted against the same gene, and between replicate RNAi screens performed in different cell lines, in different labs, and with different siRNA libraries. In an era where large-scale RNAi screens are increasingly performed to reach a systems-level understanding of cellular processes, we show that this is often improved by analyses that account for and incorporate the single-cell microenvironment. PMID:22531119

Micro-Computed Tomography Evaluation of ProTaper Next and BioRace Shaping Outcomes in Maxillary First Molar Curved Canals.

PubMed

Pasqualini, Damiano; Alovisi, Mario; Cemenasco, Andrea; Mancini, Lucia; Paolino, Davide Salvatore; Bianchi, Caterina Chiara; Roggia, Andrea; Scotti, Nicola; Berutti, Elio

2015-10-01

The aim of this micro-computed tomography study was to describe the shaping properties of ProGlider/ProTaper Next (PG/PTN) and ScoutRace/BioRace (SR/BR) nickel-titanium rotary systems. Thirty maxillary first permanent molars were selected. Mesiobuccal canals were randomly assigned (n = 15) to PG/PTN or SR/BR groups. Irrigation was performed with 5% NaOCl and 10% EDTA. Specimens were scanned (voxel size, 9.1 μm) for matching volumes and surface areas and post-treatment analyses. Root canal centering ability, canal geometry enlargement, and thickness of dentinal wall at inner curvature were assessed at apical level and point of maximum curvature. Results were analyzed with 4 one-way analyses of variance. Canal centering ability was superior in PG/PTN (P = .006 at apical level, P = .025 at point of maximum curvature). PG/PTN demonstrated a more conservative increase of canal areas (P = .027 at apical level, P = .038 at point of maximum curvature). Centrifugal increase in canal diameters did not significantly differ between groups (P = .65 at apical level, P = .61 at point of maximum curvature). Inner dentinal wall thickness was less reduced with PG/PTN compared with SR/BR, with no statistical differences (P = .23 at point of maximum curvature, P = .89 at apical level). PG/PTN shaping taper ranged between 6% and 7%. Neither system produced significant shaping errors in curved canals. PG/PTN system showed better preservation of canal anatomy. PTN offset section did not influence final preparation taper. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

[Analysis of the Association between Regional Deprivation and Utilization: An Assessment of Need for Physicians in Germany].

PubMed

Kopetsch, T; Maier, W

2018-01-01

A new strategy for planning outpatient medical care needs to be developed. The social and morbidity structure of the population should be considered in the planning of needs-based provision of medical care. This paper aims to examine the extent to which the degree of regional deprivation can be incorporated in the calculation of the regional requirements for specialists in Germany. To measure regional deprivation status at district level, we used the "German Index of Multiple Deprivation" (GIMD) developed in the Helmholtz Zentrum München - German Research Center for Environmental Health. Scores were calculated for the deprivation status of each rural and urban district in Germany. The methods used to compute the deprivation-adjusted medical need are linear regression analyses. The analyses were based on regionalized data for the number of office-based physicians and their billing data. The analyses were carried out with the SPSS software package, version 20. The analyses showed a clear positive correlation between regional deprivation and the utilisation of medical services both for outpatients and in-patients, on the one hand, and mortality and morbidity, as measured by the risk adjustment factor (RSA), on the other. At the district level, the analyses also revealed varying associations between the degree of deprivation and the utilisation of the 12 groups of specialists included in the needs assessment. On this basis, an algorithm was developed by which deprivation at district level can be used to calculate an increase or a decrease in the relative number of specialists needed. Using the GIMD and various determinants of medical utilisation, the model showed that medical need increased with the level of regional deprivation. However, regarding SHI medical specialist groups, the associations found in this analysis were statistically (R 2 ) insufficient to suggest a needs assessment planning system based only on the factors analysed, thereby restricting physicians' constitutional right of professional freedom. In particular cases, i. e. licenses to meet special needs, the developed instruments may be suitable for indicating a greater or lesser need for doctors at a regional level due to their relative ease of use and practicability. © Georg Thieme Verlag KG Stuttgart · New York.

Utilizing Climate Forecasts for Improving Water and Power Systems Coordination

NASA Astrophysics Data System (ADS)

Arumugam, S.; Queiroz, A.; Patskoski, J.; Mahinthakumar, K.; DeCarolis, J.

2016-12-01

Climate forecasts, typically monthly-to-seasonal precipitation forecasts, are commonly used to develop streamflow forecasts for improving reservoir management. Irrespective of their high skill in forecasting, temperature forecasts in developing power demand forecasts are not often considered along with streamflow forecasts for improving water and power systems coordination. In this study, we consider a prototype system to analyze the utility of climate forecasts, both precipitation and temperature, for improving water and power systems coordination. The prototype system, a unit-commitment model that schedules power generation from various sources, is considered and its performance is compared with an energy system model having an equivalent reservoir representation. Different skill sets of streamflow forecasts and power demand forecasts are forced on both water and power systems representations for understanding the level of model complexity required for utilizing monthly-to-seasonal climate forecasts to improve coordination between these two systems. The analyses also identify various decision-making strategies - forward purchasing of fuel stocks, scheduled maintenance of various power systems and tradeoff on water appropriation between hydropower and other uses - in the context of various water and power systems configurations. Potential application of such analyses for integrating large power systems with multiple river basins is also discussed.

The role of automation and artificial intelligence

NASA Astrophysics Data System (ADS)

Schappell, R. T.

1983-07-01

Consideration is given to emerging technologies that are not currently in common use, yet will be mature enough for implementation in a space station. Artificial intelligence (AI) will permit more autonomous operation and improve the man-machine interfaces. Technology goals include the development of expert systems, a natural language query system, automated planning systems, and AI image understanding systems. Intelligent robots and teleoperators will be needed, together with improved sensory systems for the robotics, housekeeping, vehicle control, and spacecraft housekeeping systems. Finally, NASA is developing the ROBSIM computer program to evaluate level of automation, perform parametric studies and error analyses, optimize trajectories and control systems, and assess AI technology.

Loss of job-related right to healthcare associated with employment turnover: challenges for the Mexican health system.

PubMed

Guerra, Germán; Gutiérrez-Calderón, Emilio; Salgado de Snyder, Nelly; Borja-Aburto, Víctor Hugo; Martínez-Valle, Adolfo; González-Block, Miguel Ángel

2018-06-15

The Mexican health system segments access and right to healthcare according to worker position in the labour market. In this contribution we analyse how access and continuity of healthcare gets interrupted by employment turnover in the labour market, including its formal and informal sectors, as experienced by affiliates to the Mexican Institute of Social Security (IMSS) at national level, and of workers with type 2 diabetes (T2DM) in Mexico City. Using data from the National Employment and Occupation Survey, 2014, and from IMSS electronic medical records for workers in Mexico City, we estimated annual employment turnover rates to measure the loss of healthcare access due to labour market dynamics. We fitted a binary logistic regression model to analyse the association between sociodemographic variables and employment turnover. Lastly we analysed job-related access to health care in relation to employment turnover events. At national level, 38.3% of IMSS affiliates experienced employment turnover at least once, thus losing the right to access to healthcare. The turnover rate for T2DM patients was 22.5%. Employment turnover was more frequent at ages 20-39 (38.6% national level; 28% T2DM) and among the elderly (62.4% national level; 26% T2DM). At the national level, higher educational levels (upper-middle, OR = 0.761; upper, OR = 0.835) and income (5 minimum wages or more, OR = 0.726) were associated with lower turnover. Being single and younger were associated with higher turnover (OR = 1.413). T2DM patients aged 40-59 (OR = 0.655) and with 5 minimum wages or more (OR = 0.401) experienced less turnover. Being a T2DM male patient increased the risk of experiencing turnover (OR = 1.166). Up to 89% of workers losing IMSS affiliation and moving on to other jobs failed to gain job-related access to health services. Only 9% gained access to the federal workers social security institute (ISSSTE). Turnover across labour market sectors is frequently experienced by the workforce in Mexico, worsening among the elderly and the young, and affecting patients with chronic diseases. This situation needs to be prospectively addressed by health system policies that aim to expand the financial health protection during an employment turnover event.

Biological Networks for Cancer Candidate Biomarkers Discovery

PubMed Central

Yan, Wenying; Xue, Wenjin; Chen, Jiajia; Hu, Guang

2016-01-01

Due to its extraordinary heterogeneity and complexity, cancer is often proposed as a model case of a systems biology disease or network disease. There is a critical need of effective biomarkers for cancer diagnosis and/or outcome prediction from system level analyses. Methods based on integrating omics data into networks have the potential to revolutionize the identification of cancer biomarkers. Deciphering the biological networks underlying cancer is undoubtedly important for understanding the molecular mechanisms of the disease and identifying effective biomarkers. In this review, the networks constructed for cancer biomarker discovery based on different omics level data are described and illustrated from recent advances in the field. PMID:27625573

Impact of high-performance work systems on individual- and branch-level performance: test of a multilevel model of intermediate linkages.

PubMed

Aryee, Samuel; Walumbwa, Fred O; Seidu, Emmanuel Y M; Otaye, Lilian E

2012-03-01

We proposed and tested a multilevel model, underpinned by empowerment theory, that examines the processes linking high-performance work systems (HPWS) and performance outcomes at the individual and organizational levels of analyses. Data were obtained from 37 branches of 2 banking institutions in Ghana. Results of hierarchical regression analysis revealed that branch-level HPWS relates to empowerment climate. Additionally, results of hierarchical linear modeling that examined the hypothesized cross-level relationships revealed 3 salient findings. First, experienced HPWS and empowerment climate partially mediate the influence of branch-level HPWS on psychological empowerment. Second, psychological empowerment partially mediates the influence of empowerment climate and experienced HPWS on service performance. Third, service orientation moderates the psychological empowerment-service performance relationship such that the relationship is stronger for those high rather than low in service orientation. Last, ordinary least squares regression results revealed that branch-level HPWS influences branch-level market performance through cross-level and individual-level influences on service performance that emerges at the branch level as aggregated service performance.

New experimental approaches to the biology of flight control systems.

PubMed

Taylor, Graham K; Bacic, Marko; Bomphrey, Richard J; Carruthers, Anna C; Gillies, James; Walker, Simon M; Thomas, Adrian L R

2008-01-01

Here we consider how new experimental approaches in biomechanics can be used to attain a systems-level understanding of the dynamics of animal flight control. Our aim in this paper is not to provide detailed results and analysis, but rather to tackle several conceptual and methodological issues that have stood in the way of experimentalists in achieving this goal, and to offer tools for overcoming these. We begin by discussing the interplay between analytical and empirical methods, emphasizing that the structure of the models we use to analyse flight control dictates the empirical measurements we must make in order to parameterize them. We then provide a conceptual overview of tethered-flight paradigms, comparing classical ;open-loop' and ;closed-loop' setups, and describe a flight simulator that we have recently developed for making flight dynamics measurements on tethered insects. Next, we provide a conceptual overview of free-flight paradigms, focusing on the need to use system identification techniques in order to analyse the data they provide, and describe two new techniques that we have developed for making flight dynamics measurements on freely flying birds. First, we describe a technique for obtaining inertial measurements of the orientation, angular velocity and acceleration of a steppe eagle Aquila nipalensis in wide-ranging free flight, together with synchronized measurements of wing and tail kinematics using onboard instrumentation and video cameras. Second, we describe a photogrammetric method to measure the 3D wing kinematics of the eagle during take-off and landing. In each case, we provide demonstration data to illustrate the kinds of information available from each method. We conclude by discussing the prospects for systems-level analyses of flight control using these techniques and others like them.

Last 900 ka river longprofile changes controlled by Yoro fault activity and glacial sea-level changes, Nobi plain, central Japan

NASA Astrophysics Data System (ADS)

Sugai, T.; Sato, T.

2015-12-01

This paper compared grain size, thickness, and lithological character of ten fluvial gravel layers formed during the glacial sea-level lowstands intervening inner bay mud layers deposited during the interglacial marine transgressional periods since the last 900 ka by integrated analyses of sediment cores including 600 m deep onein the Nobi plain, central Japan. Linkages between river long profile changes and sea-level and climate changes will be discussed. The Nobi basin is one of the representative delta type alluvial lowlands in Japan dominated by longitudinal drainage system named Kiso river system flowing southward from central Japan Alps with abundant water and sediment discharges. The basin bounded by the Yoro fault on the west has been tilted westward by the repetitive faulting activity. The basin stratigraphy and its stacking patterns suggest uniform and rapid subsidence and tilting rates of the basin with the maximum value of 1 mm yr-1 and 10-4 kyr-1 respectively produced by the Yoro fault activity under the W-E compressional regional stress field during the middle and late Quaternary periods. Tephrochronological, paleomagnetic, geochemical, and diatom analyses enabled to identify ten times repeated marine transgression-regression sequences correlated with full glacial-interglacial sea-level changes during the last 900 ka. All of the ten sequence boundaries were characterized by fluvial gravel layers were formed by the Kiso river system. The mean maximum gravel size is proportional to the magnitude of sea level lowering inferred from MIS curve, i.e. gravels deposited in MIS 12 and 16 are the largest, and those in MIS 14 and 8 are the smallest since MIS 16. This suggests that the longitudinal profile of the Kiso river system has been adjusting to the sea level changes and that the steeper longitudinal profile formed in the lower sea level periods can transport larger gravels to the drilling sites. In fact the present river bed gravel size is in proportion with the tractive force and mainly controlled by slope of the rive long-profile.

Area-level poverty, race/ethnicity & dialysis star ratings.

PubMed

Kshirsagar, Abhijit V; Manickam, Raj N; Mu, Yi; Flythe, Jennifer E; Chin, Andrew I; Bang, Heejung

2017-01-01

The Centers for Medicare and Medicaid Services recently released a five star rating system as part of 'Dialysis Facility Compare' to help patients identify and choose high performing clinics in the US. Eight dialysis-related measures determine ratings. Little is known about the association between surrounding community sociodemographic characteristics and star ratings. Using data from the U.S. Census and over 6000 dialysis clinics across the country, we examined the association between dialysis clinic star ratings and characteristics of the local population: 1) proportion of population below the federal poverty level (FPL); 2) proportion of black individuals; and 3) proportion of Hispanic individuals, by correlation and regression analyses. Secondary analyses with Quality Incentive Program (QIP) scores and population characteristics were also performed. We observed a negligible correlation between star ratings and the proportion of local individuals below FPL; Spearman coefficient, R = -0.09 (p<0.0001), and a stronger correlation between star ratings and the proportion of black individuals; R = -0.21 (p<0.0001). Ordered logistic regression analyses yielded adjusted odds ratio of 0.91 (95% confidence interval [0.80-1.30], p = 0.12) and 0.55 ([0.48-0.63], p<0.0001) for high vs. low level of proportion below FPL and proportion of black individuals, respectively. In contrast, a near-zero correlation was observed between star ratings and the proportion of Hispanic individuals. Correlations varied substantially by country region, clinic profit status and clinic size. Analyses using clinic QIP scores provided similar results. Sociodemographic characteristics of the surrounding community, factors typically outside of providers' direct control, have varying levels of association with clinic dialysis star ratings.

Complex trophic interactions of calanoid copepods in the Benguela upwelling system

NASA Astrophysics Data System (ADS)

Schukat, Anna; Auel, Holger; Teuber, Lena; Lahajnar, Niko; Hagen, Wilhelm

2014-01-01

Life-cycle adaptations, dietary preferences and trophic levels of calanoid copepods from the northern Benguela Current off Namibia were determined via lipid classes, marker fatty acids and stable isotope analyses, respectively. Trophic levels of copepod species were compared to other zooplankton and top consumers. Lipid class analyses revealed that three of the dominant calanoid copepod species stored wax esters, four accumulated triacylglycerols and another three species were characterised by high phospholipid levels. The two biomarker approaches (via fatty acids and stable isotopes) revealed a complex pattern of trophic positions for the various copepod species, but also highlighted the dietary importance of diatoms and dinoflagellates. Calanoides carinatus and Nannocalanus minor occupied the lowest trophic level (predominantly herbivorous) corresponding to high amounts of fatty acid markers for diatoms (e.g. 16:1(n - 7)) and dinoflagellates (e.g. 18:4(n - 3)). These two copepod species represent the classical link between primary production and higher trophic levels. All other copepods belonged to secondary or even tertiary (some deep-sea copepods) consumers. The calanoid copepod species cover the entire range of δ15N ratios, as compared to δ15N ratios of all non-calanoid taxa investigated, from salps to adult fish. These data emphasise that the trophic roles of calanoid copepods are far more complex than just interlinking primary producers with pelagic fish, which should also be considered in the process of developing realistic food-web models of coastal upwelling systems.

Relations between precipitation, groundwater withdrawals, and changes in hydrologic conditions at selected monitoring sites in Volusia County, Florida, 1995--2010

USGS Publications Warehouse

Murray, Louis C.

2012-01-01

A study to examine the influences of climatic and anthropogenic stressors on groundwater levels, lake stages, and surface-water discharge at selected sites in northern Volusia County, Florida, was conducted in 2009 by the U.S. Geological Survey. Water-level data collected at 20 monitoring sites (17 groundwater and 3 lake sites) in the vicinity of a wetland area were analyzed with multiple linear regression to examine the relative influences of precipitation and groundwater withdrawals on changes in groundwater levels and lake stage. Analyses were conducted across varying periods of record between 1995 and 2010 and included the effects of groundwater withdrawals aggregated from municipal water-supply wells located within 12 miles of the project sites. Surface-water discharge data at the U.S. Geological Survey Tiger Bay canal site were analyzed for changes in flow between 1978 and 2001. As expected, water-level changes in monitoring wells located closer to areas of concentrated groundwater withdrawals were more highly correlated with withdrawals than were water-level changes measured in wells further removed from municipal well fields. Similarly, water-level changes in wells tapping the Upper Floridan aquifer, the source of municipal supply, were more highly correlated with groundwater withdrawals than were water-level changes in wells tapping the shallower surficial aquifer system. Water-level changes predicted by the regression models over precipitation-averaged periods of record were underestimated for observations having large positive monthly changes (generally greater than 1.0 foot). Such observations are associated with high precipitation and were identified as points in the regression analyses that produced large standardized residuals and/or observations of high influence. Thus, regression models produced by multiple linear regression analyses may have better predictive capability in wetland environments when applied to periods of average or below average precipitation conditions than during wetter than average conditions. For precipitation-averaged hydrologic conditions, water-level changes in the surficial aquifer system were statistically correlated solely with precipitation or were more highly correlated with precipitation than with groundwater withdrawals. Changes in Upper Floridan aquifer water levels and in water-surface stage (stage) at Indian and Scoggin Lakes tended to be highly correlated with both precipitation and withdrawals. The greater influence of withdrawals on stage changes, relative to changes in nearby surficial aquifer system water levels, indicates that these karstic lakes may be better connected hydraulically with the underlying Upper Floridan aquifer than is the surficial aquifer system at the other monitoring sites. At most sites, and for both aquifers, the 2-month moving average of precipitation or groundwater withdrawals included as an explanatory variable in the regression models indicates that water-level changes are not only influenced by stressor conditions across the current month, but also by those of the previous month. The relations between changes in water levels, precipitation, and groundwater withdrawals varied seasonally and in response to a period of drought. Water-level changes tended to be most highly correlated with withdrawals during the spring, when relatively large increases contributed to water-level declines, and during the fall when reduced withdrawal rates contributed to water-level recovery. Water-level changes tended to be most highly (or solely) correlated with precipitation in the winter, when withdrawals are minimal, and in the summer when precipitation is greatest. Water-level changes measured during the drought of October 2005 to June 2008 tended to be more highly correlated with groundwater withdrawals at Upper Floridan aquifer sites than at surficial aquifer system sites, results that were similar to those for precipitation-averaged conditions. Also, changes in stage at Indian and Scoggin Lakes were highly correlated with precipitation and groundwater withdrawals during the drought. Groundwater-withdrawal rates during the drought were, on average, greater than those for precipitation-averaged conditions. Accounting only for withdrawals aggregated from pumping wells located within varying radial distances of less than 12 miles of each site produced essentially the same relation between water-level changes and groundwater withdrawals as that determined for withdrawals aggregated within 12 miles of the site. Similarly, increases in withdrawals aggregated over distances of 1 to 12 miles of the sites had little effect on adjusted R-squared values. Analyses of streamflow measurements collected between 1978 and 2001 at the U.S. Geological Survey Tiger Bay canal site indicate that significant changes occurred during base-flow conditions during that period. Hypothesis and trend testing, together with analyses of flow duration, the number of zero-flow days, and double-mass curves indicate that, after 1988, when a municipal well field began production, base flow was statistically lower than the period before 1988. This decrease in base flow could not be explained by variations in precipitation between these two periods.

A systems approach to the policy-level risk assessment of exotic animal diseases: network model and application to classical swine fever.

PubMed

Delgado, João; Pollard, Simon; Snary, Emma; Black, Edgar; Prpich, George; Longhurst, Phil

2013-08-01

Exotic animal diseases (EADs) are characterized by their capacity to spread global distances, causing impacts on animal health and welfare with significant economic consequences. We offer a critique of current import risk analysis approaches employed in the EAD field, focusing on their capacity to assess complex systems at a policy level. To address the shortcomings identified, we propose a novel method providing a systematic analysis of the likelihood of a disease incursion, developed by reference to the multibarrier system employed for the United Kingdom. We apply the network model to a policy-level risk assessment of classical swine fever (CSF), a notifiable animal disease caused by the CSF virus. In doing so, we document and discuss a sequence of analyses that describe system vulnerabilities and reveal the critical control points (CCPs) for intervention, reducing the likelihood of U.K. pig herds being exposed to the CSF virus. © 2012 Society for Risk Analysis.

Lightning tests and analyses of tunnel bond straps and shielded cables on the Space Shuttle solid rocket booster

NASA Technical Reports Server (NTRS)

Druen, William M.

1993-01-01

The purposes of the tests and analyses described in this report are as follows: (1) determine the lightning current survivability of five alternative changed designs of the bond straps which electrically bond the solid rocket booster (SRB) systems tunnel to the solid rocket motor (SRM) case; (2) determine the amount of reduction in induced voltages on operational flight (OF) tunnel cables obtained by a modified design of tunnel bond straps (both tunnel cover-to-cover and cover-to-motor case); (3) determine the contribution of coupling to the OF tunnel cables by ground electrical and instrumentation (GEI) cables which enter the systems tunnel from unshielded areas on the surfaces of the motor case; and (4) develop a model (based on test data) and calculate the voltage levels at electronic 'black boxes' connected to the OF cables that run in the systems tunnel.

Failure detection and isolation analysis of a redundant strapdown inertial measurement unit

NASA Technical Reports Server (NTRS)

Motyka, P.; Landey, M.; Mckern, R.

1981-01-01

The objective of this study was to define and develop techniques for failure detection and isolation (FDI) algorithms for a dual fail/operational redundant strapdown inertial navigation system are defined and developed. The FDI techniques chosen include provisions for hard and soft failure detection in the context of flight control and navigation. Analyses were done to determine error detection and switching levels for the inertial navigation system, which is intended for a conventional takeoff or landing (CTOL) operating environment. In addition, investigations of false alarms and missed alarms were included for the FDI techniques developed, along with the analyses of filters to be used in conjunction with FDI processing. Two specific FDI algorithms were compared: the generalized likelihood test and the edge vector test. A deterministic digital computer simulation was used to compare and evaluate the algorithms and FDI systems.

Individual characteristics, area social participation, and primary non-concordance with medication: a multilevel analysis.

PubMed

Johnell, Kristina; Lindström, Martin; Sundquist, Jan; Eriksson, Charli; Merlo, Juan

2006-03-02

Non-concordance with medication remains a major public health problem that imposes a considerable financial burden on the health care system, and there is still a need for studies on correlates of non-concordance. Our first aim is to analyse whether any of the individual characteristics age, educational level, financial strain, self-rated health, social participation, and trust in the health care system are associated with primary non-concordance with medication. Our second aim is to investigate whether people living in the same area have similar probability of primary non-concordance with medication, that relates to area social participation. We analysed cross sectional data from 9,070 women and 6,795 men aged 18 to 79 years, living in 78 areas in central Sweden, who participated in the Life & Health year 2000 survey, with multilevel logistic regression (individuals at the first level and areas at the second level). Younger age, financial strain, low self-rated health, and low trust in the health care system were associated with primary non-concordance with medication. However, area social participation was not related to primary non-concordance, and the variation in primary non-concordance between the areas was small. Our results indicate that people in central Sweden with younger age, financial difficulties, low self-rated health, and low trust in the health care system may have a higher probability of primary non-concordance with medication. However, the area of residence--as defined by administrative boundaries--seems to play a minor role for primary non-concordance.

Individual characteristics, area social participation, and primary non-concordance with medication: a multilevel analysis

PubMed Central

Johnell, Kristina; Lindström, Martin; Sundquist, Jan; Eriksson, Charli; Merlo, Juan

2006-01-01

Background Non-concordance with medication remains a major public health problem that imposes a considerable financial burden on the health care system, and there is still a need for studies on correlates of non-concordance. Our first aim is to analyse whether any of the individual characteristics age, educational level, financial strain, self-rated health, social participation, and trust in the health care system are associated with primary non-concordance with medication. Our second aim is to investigate whether people living in the same area have similar probability of primary non-concordance with medication, that relates to area social participation. Methods We analysed cross sectional data from 9 070 women and 6 795 men aged 18 to 79 years, living in 78 areas in central Sweden, who participated in the Life & Health year 2000 survey, with multilevel logistic regression (individuals at the first level and areas at the second level). Results Younger age, financial strain, low self-rated health, and low trust in the health care system were associated with primary non-concordance with medication. However, area social participation was not related to primary non-concordance, and the variation in primary non-concordance between the areas was small. Conclusion Our results indicate that people in central Sweden with younger age, financial difficulties, low self-rated health, and low trust in the health care system may have a higher probability of primary non-concordance with medication. However, the area of residence – as defined by administrative boundaries – seems to play a minor role for primary non-concordance. PMID:16512907

The roles of individual and organizational factors in burnout among community-based mental health service providers.

PubMed

Green, Amy E; Albanese, Brian J; Shapiro, Nicole M; Aarons, Gregory A

2014-02-01

Public-sector mental health care providers are at high risk for burnout, which negatively affects not only provider well-being but also the quality of services for clients and the functioning of organizations. This study examines the influence of demographics, work characteristic, and organizational variables on levels of burnout among child and adolescent mental health service providers operating within a public-sector mental health service system. Additionally, given the dearth of research examining differences in burnout levels among mental health subdisciplines (e.g., social work, psychology, marital and family therapy) and mental health programs (e.g., outpatient, day treatment, wraparound, case management), analyses were conducted to compare levels of burnout among multiple mental health disciplines and program types. Surveys were completed by 285 providers across 49 mental health programs in a large urban public mental health system. Variables representing dimensions of organizational climate and transformational leadership accounted for the greatest amount of variance in provider reported burnout. Analyses demonstrated significantly lower levels of depersonalization among wraparound providers compared to traditional case managers. Age was the only demographic variable related to burnout. Additionally, no significant effects were found for provider discipline or for agency tenure and caseload size. Results suggest the need to consider organizational development strategies aimed at creating more functional and less stressful climates and increasing levels of transformational leadership behaviors in order to reduce levels of burnout among clinicians working in public mental health settings for youth and families. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Oligotrophy as a major driver of mercury bioaccumulation in medium-to high-trophic level consumers: A marine ecosystem-comparative study.

PubMed

Chouvelon, Tiphaine; Cresson, Pierre; Bouchoucha, Marc; Brach-Papa, Christophe; Bustamante, Paco; Crochet, Sylvette; Marco-Miralles, Françoise; Thomas, Bastien; Knoery, Joël

2018-02-01

Mercury (Hg) is a global contaminant of environmental concern. Numerous factors influencing its bioaccumulation in marine organisms have already been described at both individual and species levels (e.g., size or age, habitat, trophic level). However, few studies have compared the trophic characteristics of ecosystems to explain underlying mechanisms of differences in Hg bioaccumulation and biomagnification among food webs and systems. The present study aimed at investigating the potential primary role of the trophic status of systems on Hg bioaccumulation and biomagnification in temperate marine food webs, as shown by their medium-to high-trophic level consumers. It used data from samples collected at the shelf-edge (i.e. offshore organisms) in two contrasted ecosystems: the Bay of Biscay in the North-East Atlantic Ocean and the Gulf of Lion in the North-West Mediterranean Sea. Seven species including crustaceans, sharks and teleost fish, previously analysed for their total mercury (T-Hg) concentrations and their stable carbon and nitrogen isotope compositions, were considered for a meta-analysis. In addition, methylated mercury forms (or methyl-mercury, Me-Hg) were analysed. Mediterranean organisms presented systematically lower sizes than Atlantic ones, and lower δ 13 C and δ 15 N values, the latter values especially highlighting the more oligotrophic character of Mediterranean waters. Mediterranean individuals also showed significantly higher T-Hg and Me-Hg concentrations. Conversely, Me-Hg/T-Hg ratios were higher than 85% for all species, and quite similar between systems. Finally, the biomagnification power of Hg was different between systems when considering T-Hg, but not when considering Me-Hg, and was not different between the Hg forms within a given system. Overall, the different parameters showed the crucial role of the low primary productivity and its effects rippling through the compared ecosystems in the higher Hg bioaccumulation seen in organisms from oligotrophic Mediterranean waters. Copyright © 2017 Elsevier Ltd. All rights reserved.

Preparing for the data revolution: identifying minimum health information competencies among the health workforce.

PubMed

Whittaker, Maxine; Hodge, Nicola; Mares, Renata E; Rodney, Anna

2015-04-01

Health information is required for a variety of purposes at all levels of a health system, and a workforce skilled in collecting, analysing, presenting, and disseminating such information is essential to fulfil these demands. While it is established that low- and middle-income countries (LMICs) are facing shortages in human resources for health (HRH), there has been little systematic attention focussed on non-clinical competencies. In response, we developed a framework that defines the minimum health information competencies required by health workers at various levels of a health system. Using the Delphi method, we consulted with leading global health information system (HIS) experts. An initial list of competencies and draft framework were developed based on results of a systematic literature review. During the second half of 2012, we sampled 38 experts with broad-based HIS knowledge and extensive development experience. Two rounds of consultation were carried out with the same group to establish validity of the framework and gain feedback on the draft competencies. Responses from consultations were analysed using Qualtrics® software and content analysis. In round one, 17 experts agreed to participate in the consultation and 11 (65%) completed the survey. In the second round, 11 experts agreed to participate and eight (73%) completed the survey. Overall, respondents agreed that there is a need for all health workers to have basic HIS competencies and that the concept of a minimum HIS competency framework is valid. Consensus was reached around the inclusion of 68 competencies across four levels of a health system. This consultation is one of the first to identify the HIS competencies required among general health workers, as opposed to specialist HIS roles. It is also one of the first attempts to develop a framework on minimum HIS competencies needed in LMICs, highlighting the skills needed at each level of the system, and identifying potential gaps in current training to allow a more systematic approach to HIS capacity-building.

Safety assessment of underground vehicles passing over highly resilient curved tracks in the presence of a broken rail

NASA Astrophysics Data System (ADS)

Suárez, B.; Rodriguez, P.; Vázquez, M.; Fernández, I.

2012-01-01

Vehicle-track interaction for a new resilient slab track designed to reduce noise and vibration levels was analysed, in order to assess the derailment risk on a curved track when encountering a broken rail. Sensitivity of the rail support spacing of the relative position of the rail breakage between two adjacent rail supports and of running speed were analysed for two different elasticities of the rail fastening system. In none of the cases analysed was observed an appreciable difference between either of the elastic systems. As was expected, the most unfavourable situations were those with greater rail support spacing and those with greater distance from the breakage to the nearest rail support, although in none of the simulations performed did a derailment occur when running over the broken rail. When varying the running speed, the most favourable condition was obtained for an intermediate speed, due to the superposition of two antagonistic effects.

"ATLAS" Advanced Technology Life-cycle Analysis System

NASA Technical Reports Server (NTRS)

Lollar, Louis F.; Mankins, John C.; ONeil, Daniel A.

2004-01-01

Making good decisions concerning research and development portfolios-and concerning the best systems concepts to pursue - as early as possible in the life cycle of advanced technologies is a key goal of R&D management This goal depends upon the effective integration of information from a wide variety of sources as well as focused, high-level analyses intended to inform such decisions Life-cycle Analysis System (ATLAS) methodology and tool kit. ATLAS encompasses a wide range of methods and tools. A key foundation for ATLAS is the NASA-created Technology Readiness. The toolkit is largely spreadsheet based (as of August 2003). This product is being funded by the Human and Robotics The presentation provides a summary of the Advanced Technology Level (TRL) systems Technology Program Office, Office of Exploration Systems, NASA Headquarters, Washington D.C. and is being integrated by Dan O Neil of the Advanced Projects Office, NASA/MSFC, Huntsville, AL

Long-term health experience of jet engine manufacturing workers: V. Issues with the analysis of non-malignant central nervous system neoplasms.

PubMed

Buchanich, Jeanine M; Youk, Ada O; Marsh, Gary M; Kennedy, Kathleen J; Lacey, Steven E; Hancock, Roger P; Esmen, Nurtan A; Cunningham, Michael A; Leiberman, Frank S; Fleissner, Mary Lou

2011-01-01

We attempted to examine non-malignant central nervous system (CNS) neoplasms incidence rates for workers at 8 jet engine manufacturing facilities in Connecticut. The objective of this manuscript is to describe difficulties encountered regarding these analyses to aid future studies. We traced the cohort for incident cases of CNS neoplasms in states where 95% of deaths in the total cohort occurred. We used external and internal analyses in an attempt to obtain the true risk of non-malignant CNS in the cohort. Because these analyses were limited by data constraints, we conducted sensitivity analyses, including using state driver's license data to adjust person-year stop dates to help minimize underascertainment and more accurately determine cohort risk estimates. We identified 3 unanticipated challenges: case identification, determination of population-based cancer incidence rates, and handling of case underascertainment. These factors precluded an accurate assessment of non-malignant CNS neoplasm incidence risks in this occupational epidemiology study. The relatively recent (2004) mandate of capturing non-malignant CNS tumor data at the state level means that, in time, it may be possible to conduct external analyses of these data. Meanwhile, similar occupational epidemiology studies may be limited to descriptive analysis of the non-malignant CNS case characteristics.

Transportation analyses for the lunar-Mars initiative

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Buddington, Patricia A.

1991-01-01

This paper focuses on certain results of an ongoing NASA-sponsored study by Boeing, including (1) a series of representative space exploration scenarios; (2) the levels of effort required to accomplish each; and (3) a range of candidate transportation system as partial implementations of the scenarios. This effort predated release of the Synthesis report; the three levels of activity described are not responses to the Synthesis architectures. These three levels (minimum, median and ambitious), do envelope the range of scope described in the four Synthesis architecture models. The level of analysis detail was to the current known level of detail of transportation hardware systems and mission scenarios. The study did not include detailed analysis of earth-to-orbit transportation, surface systems, or tracking and communications systems. The influence of earth-to-orbit systems was considered in terms of delivery capacity and cost. Aspects of additional options, such as in situ resource utilization are explored as needed to indicate potential benefits. Results favored cryogenic chemical propulsion for low activity levels and undemanding missions (such as cargo and some lunar missions), nuclear thermal propulsion for median activity levels similar to the Synthesis architectures, and nuclear thermal propulsion with aerobraking or nuclear electric propulsion for high activity levels. Solar electric propulsion was seen as having an important role if the present high unit cost (i.e., dollars per watt) of space photovoltaics could be reduced by a factor of five or more at production rates of megawatts per year.

Space construction system analysis. Part 2: Platform definition

NASA Technical Reports Server (NTRS)

Hart, R. J.; Myers, H. L.; Abramson, R. D.; Dejong, P. N.; Donavan, R. D.; Greenberg, H. S.; Indrikis, J.; Jandrasi, J. S.; Manoff, M.; Mcbaine, C. K.

1980-01-01

The top level system requirements are summarized and the accompanying conceptual design for an engineering and technology verification platform (ETVP) system is presented. An encompassing statement of the system objectives which drive the system requirements is presented and the major mission and subsystem requirements are described with emphasis on the advanced communications technology mission payload. The platform design is defined and used as a reference configuration for an end to space construction analyses. The preferred construction methods and processes, the important interactions between the platform design and the construction system design and operation, and the technology development efforts required to support the design and space construction of the ETVP are outlined.

Systems Engineering and Integration for Advanced Life Support System and HST

NASA Technical Reports Server (NTRS)

Kamarani, Ali K.

2005-01-01

Systems engineering (SE) discipline has revolutionized the way engineers and managers think about solving issues related to design of complex systems: With continued development of state-of-the-art technologies, systems are becoming more complex and therefore, a systematic approach is essential to control and manage their integrated design and development. This complexity is driven from integration issues. In this case, subsystems must interact with one another in order to achieve integration objectives, and also achieve the overall system's required performance. Systems engineering process addresses these issues at multiple levels. It is a technology and management process dedicated to controlling all aspects of system life cycle to assure integration at all levels. The Advanced Integration Matrix (AIM) project serves as the systems engineering and integration function for the Human Support Technology (HST) program. AIM provides means for integrated test facilities and personnel for performance trade studies, analyses, integrated models, test results, and validated requirements of the integration of HST. The goal of AIM is to address systems-level integration issues for exploration missions. It will use an incremental systems integration approach to yield technologies, baselines for further development, and possible breakthrough concepts in the areas of technological and organizational interfaces, total information flow, system wide controls, technical synergism, mission operations protocols and procedures, and human-machine interfaces.

A ZigBee wireless networking for remote sensing applications in hydrological monitoring system

NASA Astrophysics Data System (ADS)

Weng, Songgan; Zhai, Duo; Yang, Xing; Hu, Xiaodong

2017-01-01

Hydrological monitoring is recognized as one of the most important factors in hydrology. Particularly, investigation of the tempo-spatial variation patterns of water-level and their effect on hydrological research has attracted more and more attention in recent. Because of the limitations in both human costs and existing water-level monitoring devices, however, it is very hard for researchers to collect real-time water-level data from large-scale geographical areas. This paper designs and implements a real-time water-level data monitoring system (MCH) based on ZigBee networking, which explicitly serves as an effective and efficient scientific instrument for domain experts to facilitate the measurement of large-scale and real-time water-level data monitoring. We implement a proof-of-concept prototype of the MCH, which can monitor water-level automatically, real-timely and accurately with low cost and low power consumption. The preliminary laboratory results and analyses demonstrate the feasibility and the efficacy of the MCH.

Time-Frequency Analyses of Tide-Gauge Sensor Data

PubMed Central

Erol, Serdar

2011-01-01

The real world phenomena being observed by sensors are generally non-stationary in nature. The classical linear techniques for analysis and modeling natural time-series observations are inefficient and should be replaced by non-linear techniques of whose theoretical aspects and performances are varied. In this manner adopting the most appropriate technique and strategy is essential in evaluating sensors’ data. In this study, two different time-series analysis approaches, namely least squares spectral analysis (LSSA) and wavelet analysis (continuous wavelet transform, cross wavelet transform and wavelet coherence algorithms as extensions of wavelet analysis), are applied to sea-level observations recorded by tide-gauge sensors, and the advantages and drawbacks of these methods are reviewed. The analyses were carried out using sea-level observations recorded at the Antalya-II and Erdek tide-gauge stations of the Turkish National Sea-Level Monitoring System. In the analyses, the useful information hidden in the noisy signals was detected, and the common features between the two sea-level time series were clarified. The tide-gauge records have data gaps in time because of issues such as instrumental shortcomings and power outages. Concerning the difficulties of the time-frequency analysis of data with voids, the sea-level observations were preprocessed, and the missing parts were predicted using the neural network method prior to the analysis. In conclusion the merits and limitations of the techniques in evaluating non-stationary observations by means of tide-gauge sensors records were documented and an analysis strategy for the sequential sensors observations was presented. PMID:22163829

Time-frequency analyses of tide-gauge sensor data.

PubMed

Erol, Serdar

2011-01-01

The real world phenomena being observed by sensors are generally non-stationary in nature. The classical linear techniques for analysis and modeling natural time-series observations are inefficient and should be replaced by non-linear techniques of whose theoretical aspects and performances are varied. In this manner adopting the most appropriate technique and strategy is essential in evaluating sensors' data. In this study, two different time-series analysis approaches, namely least squares spectral analysis (LSSA) and wavelet analysis (continuous wavelet transform, cross wavelet transform and wavelet coherence algorithms as extensions of wavelet analysis), are applied to sea-level observations recorded by tide-gauge sensors, and the advantages and drawbacks of these methods are reviewed. The analyses were carried out using sea-level observations recorded at the Antalya-II and Erdek tide-gauge stations of the Turkish National Sea-Level Monitoring System. In the analyses, the useful information hidden in the noisy signals was detected, and the common features between the two sea-level time series were clarified. The tide-gauge records have data gaps in time because of issues such as instrumental shortcomings and power outages. Concerning the difficulties of the time-frequency analysis of data with voids, the sea-level observations were preprocessed, and the missing parts were predicted using the neural network method prior to the analysis. In conclusion the merits and limitations of the techniques in evaluating non-stationary observations by means of tide-gauge sensors records were documented and an analysis strategy for the sequential sensors observations was presented.

Liquid level sensor based on fiber ring laser with single-mode-offset coreless-single-mode fiber structure

NASA Astrophysics Data System (ADS)

Wang, Zixiao; Tan, Zhongwei; Xing, Rui; Liang, Linjun; Qi, Yanhui; Jian, Shuisheng

2016-10-01

A novel reflective liquid level sensor based on single-mode-offset coreless-single-mode (SOCS) fiber structure is proposed and experimentally demonstrated. Theory analyses and experimental results indicate that offset fusion can remarkably enhance the sensitivity of sensor. Ending-reflecting structure makes the sensor compact and easy to deploy. Meanwhile, we propose a laser sensing system, and the SOCS structure is used as sensing head and laser filter simultaneously. Experimental results show that laser spectra with high optical signal-to-noise ratio (-30 dB) and narrow 3-dB bandwidth (<0.15 nm) are achieved. Various liquids with different indices are used for liquid level sensing, besides, the refractive index sensitivity is also investigated. In measurement range, the sensing system presents steady laser output.

Examining Dehydration and Hypoxic Stress in Wheat Plants Using a Porous Tube Plant Nutrient Delivery System Developed for Microgravity

NASA Technical Reports Server (NTRS)

Dreschel, T. W.; Hall, C. R.; Foster, T. E.; Salganic, M.; Warren, L.; Corbett, M.

2005-01-01

The Porous Tube Plant Nutrient Delivery System (PTPNDS) was designed for NASA to grow plants in microgravity of space. The system utilizes a controlled fluid loop to supply nutrients and water to plant roots growing on a ceramic surface moistened by capiflary action. A PTPNDS test bed was developed and utilizing remote sensing systems, spectral analyses procedures, gas-exchange, and fluorescence measurements, we examined differences in plant water status for wheat plants (Triticum aestivum, cv. Perigee) grown in a modified growth chamber during the summers of 2003 and 2004. Some differences in plant performance were detectable in the gas-exchange and fluorescence measurements. For instance, in both years the plants grown with the most available water had the lowest rates of photosynthesis and exhibited higher proportions of non-photochemical quenching particularly under low light levels. In addition, small differences in mean leaf water content between treatments were detected using spectral reflectance analyses.

Analysing malaria incidence at the small area level for developing a spatial decision support system: A case study in Kalaburagi, Karnataka, India.

PubMed

Shekhar, S; Yoo, E-H; Ahmed, S A; Haining, R; Kadannolly, S

2017-02-01

Spatial decision support systems have already proved their value in helping to reduce infectious diseases but to be effective they need to be designed to reflect local circumstances and local data availability. We report the first stage of a project to develop a spatial decision support system for infectious diseases for Karnataka State in India. The focus of this paper is on malaria incidence and we draw on small area data on new cases of malaria analysed in two-monthly time intervals over the period February 2012 to January 2016 for Kalaburagi taluk, a small area in Karnataka. We report the results of data mapping and cluster detection (identifying areas of excess risk) including evaluating the temporal persistence of excess risk and the local conditions with which high counts are statistically associated. We comment on how this work might feed into a practical spatial decision support system. Copyright © 2017 Elsevier Ltd. All rights reserved.

BacillOndex: an integrated data resource for systems and synthetic biology.

PubMed

Misirli, Goksel; Wipat, Anil; Mullen, Joseph; James, Katherine; Pocock, Matthew; Smith, Wendy; Allenby, Nick; Hallinan, Jennifer S

2013-04-10

BacillOndex is an extension of the Ondex data integration system, providing a semantically annotated, integrated knowledge base for the model Gram-positive bacterium Bacillus subtilis. This application allows a user to mine a variety of B. subtilis data sources, and analyse the resulting integrated dataset, which contains data about genes, gene products and their interactions. The data can be analysed either manually, by browsing using Ondex, or computationally via a Web services interface. We describe the process of creating a BacillOndex instance, and describe the use of the system for the analysis of single nucleotide polymorphisms in B. subtilis Marburg. The Marburg strain is the progenitor of the widely-used laboratory strain B. subtilis 168. We identified 27 SNPs with predictable phenotypic effects, including genetic traits for known phenotypes. We conclude that BacillOndex is a valuable tool for the systems-level investigation of, and hypothesis generation about, this important biotechnology workhorse. Such understanding contributes to our ability to construct synthetic genetic circuits in this organism.

BacillOndex: An Integrated Data Resource for Systems and Synthetic Biology.

PubMed

Misirli, Goksel; Wipat, Anil; Mullen, Joseph; James, Katherine; Pocock, Matthew; Smith, Wendy; Allenby, Nick; Hallinan, Jennifer S

2013-06-01

BacillOndex is an extension of the Ondex data integration system, providing a semantically annotated, integrated knowledge base for the model Gram-positive bacterium Bacillus subtilis. This application allows a user to mine a variety of B. subtilis data sources, and analyse the resulting integrated dataset, which contains data about genes, gene products and their interactions. The data can be analysed either manually, by browsing using Ondex, or computationally via a Web services interface. We describe the process of creating a BacillOndex instance, and describe the use of the system for the analysis of single nucleotide polymorphisms in B. subtilis Marburg. The Marburg strain is the progenitor of the widely-used laboratory strain B. subtilis 168. We identified 27 SNPs with predictable phenotypic effects, including genetic traits for known phenotypes. We conclude that BacillOndex is a valuable tool for the systems-level investigation of, and hypothesis generation about, this important biotechnology workhorse. Such understanding contributes to our ability to construct synthetic genetic circuits in this organism.

CAPITATION IN HEALTHCARE FINANCING IN GHANA.

PubMed

Aboagye, A Q Q

2013-05-01

To analyse implementation of the pilot study of the per capita system of healthcare financing in Ghana in 2012 for a determination of the likelihood of realising the inherent theoretical benefits when the system is rolled out nationally. First, publicly available information on how the pilot unfolded is presented, followed by the reaction of the health authorities to these developments. We then analysed accrued evidence on costs and developments vis-à-vis the theoretical benefits. It would appear that preparation for the pilot exercise could have been handled better. Concerns include i) the low level of both education and awareness of the capitation system among healthcare subscribers and primary care providers; ii) confusion about service provider to whom subscribers had been assigned for the capitation period; and iii) service providers not understanding differences between capitation financing and financing under the Ghana diagnostic Related Grouping; and iv) some indication of cost savings. Cost savings may be available nationally. This is important because cost containment is the driving force behind the introduction of the capitation system.

Estimation of potential scour at bridges on local government roads in South Dakota, 2009-12

USGS Publications Warehouse

Thompson, Ryan F.; Wattier, Chelsea M.; Liggett, Richard R.; Truax, Ryan A.

2014-01-01

In 2009, the U.S. Geological Survey and South Dakota Department of Transportation (SDDOT) began a study to estimate potential scour at selected bridges on local government (county, township, and municipal) roads in South Dakota. A rapid scour-estimation method (level-1.5) and a more detailed method (level-2) were used to develop estimates of contraction, abutment, and pier scour. Data from 41 level-2 analyses completed for this study were combined with data from level-2 analyses completed in previous studies to develop new South Dakota-specific regression equations: four regional equations for main-channel velocity at the bridge contraction to account for the widely varying stream conditions within South Dakota, and one equation for head change. Velocity data from streamgages also were used in the regression for average velocity through the bridge contraction. Using these new regression equations, scour analyses were completed using the level-1.5 method on 361 bridges on local government roads. Typically, level-1.5 analyses are completed at flows estimated to have annual exceedance probabilities of 1 percent (100-year flood) and 0.2 percent (500-year flood); however, at some sites the bridge would not pass these flows. A level-1.5 analysis was then completed at the flow expected to produce the maximum scour. Data presented for level-1.5 scour analyses at the 361 bridges include contraction, abutment, and pier scour. Estimates of potential contraction scour ranged from 0 to 32.5 feet for the various flows evaluated. Estimated potential abutment scour ranged from 0 to 40.9 feet for left abutments, and from 0 to 37.7 feet for right abutments. Pier scour values ranged from 2.7 to 31.6 feet. The scour depth estimates provided in this report can be used by the SDDOT to compare with foundation depths at each bridge to determine if abutments or piers are at risk of being undermined by scour at the flows evaluated. Replicate analyses were completed at 24 of the 361 bridges to provide quality-assurance/quality-control measures for the level-1.5 scour estimates. An attempt was made to use the same flows among replicate analyses. Scour estimates do not necessarily have to be in numerical agreement to give the same results. For example, if contraction scour replicate analyses are 18.8 and 30.8 feet, both scour depths can indicate susceptibility to scour for which countermeasures may be needed, even though one number is much greater than the other number. Contraction scour has perhaps the greatest potential for being estimated differently in replicate visits. For contraction scour estimates at the various flows analyzed, differences between results ranged from -7.8 to 5.5 feet, with a median difference of 0.4 foot and an average difference of 0.2 foot. Abutment scour appeared to be nearly as reproducible as contraction scour. For abutment scour estimates at the varying flows analyzed, differences between results ranged from -17.4 to 11 feet, with a median difference of 1.4 feet and an average difference of 1.7 feet. Estimates of pier scour tended to be the most consistently reproduced in replicate visits, with differences between results ranging from -0.3 to 0.5 foot, with a median difference of 0.0 foot and an average difference of 0.0 foot. The U.S. Army Corps of Engineers Hydraulics Engineering Center River Analysis Systems (HEC-RAS) software package was used to model stream hydraulics at the 41 sites with level-2 analyses. Level-1.5 analyses also were completed at these sites, and the performance of the level-1.5 method was assessed by comparing results to those from the more rigorous level-2 method. The envelope curve approach used in the level-1.5 method is designed to overestimate scour relative to the estimate from the level-2 scour analysis. In cases where the level-1.5 method estimated less scour than the level-2 method, the amount of underestimation generally was less than 3 feet. The level-1.5 method generally overestimated contraction, abutment, and pier scour relative to the level-2 method, as intended. Although the level-1.5 method is designed to overestimate scour relative to more involved analysis methods, many assumptions, uncertainties, and estimations are involved. If the envelope curves are adjusted such that the level-1.5 method never underestimates scour relative to the level-2 method, an accompanying result may be excessive overestimation.

Quest for Accountability: Exploring the Evaluation Process of Universities

ERIC Educational Resources Information Center

Minelli, Eliana; Rebora, Gianfranco; Turri, Matteo

2015-01-01

The article explores the organisational impact of evaluation and control mechanisms on universities from the point of view of accountability. Three case studies are analysed with the aim of understanding the significance of these systems both at corporate governance level and in relation to their influence on the behaviour of the academic staff.…

International Briefing 36: Training and Development in Ecuador

ERIC Educational Resources Information Center

Ramirez-Anormaliza, Richard; Llinàs-Audet, Xavier; Sabaté, Ferran

2017-01-01

This article examines educational policies in Ecuador. It outlines the main features of the education and training systems, and analyses the impact on productivity and national development. The efforts made by various national authorities to strengthen and encourage education at all levels is evident, as well as efforts to boost productivity by…

A framework for identifying carbon hotspots and forest management drivers

Treesearch

Nilesh Timilsina; Francisco J. Escobedo; Wendell P. Cropper; Amr Abd-Elrahman; Thomas Brandeis; Sonia Delphin; Samuel Lambert

2013-01-01

Spatial analyses of ecosystem system services that are directly relevant to both forest management decision making and conservation in the subtropics are rare. Also, frameworks that identify and map carbon stocks and corresponding forest management drivers using available regional, national, and international-level forest inventory datasets could provide insights into...

Access to Higher Education in Chile: A Public vs. Private Analysis

ERIC Educational Resources Information Center

Espinoza, Oscar; González, Luis Eduardo

2013-01-01

This study analyzes how access to public and private institutions of higher education in Chile has changed as the post-secondary system has become increasingly privatized. It analyses access by young people to higher education from four perspectives: funding type (public/private), gender, family income level, and ethnicity. The study uses…

Vehicle-based countermeasures for signal and stop sign violations. Task 1, Intersection control violation crash analyses. Task 2, Top-level system and human factors requirements

DOT National Transportation Integrated Search

2004-03-01

The report provides the first two major task reports for a study to develop performance specifications and perform supporting objective tests for a planned field operational test (FOT) of a vehicle-based countermeasure to intersection crashes associa...

Governance and Institutional Autonomy: Governing and Governance in Portuguese Higher Education

ERIC Educational Resources Information Center

Magalhaes, Antonio; Veiga, Amelia; Ribeiro, Filipa; Amaral, Alberto

2013-01-01

This paper aims at looking at governance instruments beyond managerial technicality. It intends to do so by analysing the impact of governance reforms on the universities autonomy assumed as a regulation instrument to politically steer systems and institutions. The regulation efforts undertaken at the European and national levels reflect a trend…

Private Schools and Public Benefit: Fees, Fee Remissions, and Subsidies

ERIC Educational Resources Information Center

Davies, Peter

2011-01-01

The level of fee remissions offered by private schools bears upon the scope for relying on private schools to provide public benefit. Analyses of education voucher systems have generally ignored the possibility that they will partially crowd out school-financed fee remissions. Moreover, variation in fee remissions between private schools may be…

The Tunisian Educational Reform: From Quantity to Quality and the Need for Monitoring and Assessment

ERIC Educational Resources Information Center

Akkari, Abdeljalil

2005-01-01

The Tunisian education system, like that of many other Southern nations of intermediate wealth, finds itself pulled in opposing directions. While quantitative advances at different levels of instruction have been easily achieved, a reorientation towards qualitative matters is nowadays more than ever necessary. This article analyses developments…

Shifting Roles and Approaches: Government Coordination of Post-Secondary Education in Canada, 1995-2006

ERIC Educational Resources Information Center

Shanahan, Theresa; Jones, Glen A.

2007-01-01

This paper analyses changing approaches to system-level governance in Canadian post-secondary education from 1995-2006. A review of major policy initiatives reveals a shift in provincial and federal government roles in and approaches to the coordination of post-secondary education. The federal government has strategically invested in…

The expression of APRIL in Sjögren’s syndrome: aberrant expression of APRIL in the salivary gland

PubMed Central

Roescher, Nienke; Polling, Eline J.; Illei, Gabor G.; Tak, Paul P.

2012-01-01

Objective. A proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF) are B-cell-related mediators and may play a role in the pathogenesis in SS. In this descriptive study we assessed the expression of APRIL and BAFF in the minor salivary gland and serum from SS patients. Methods. Paraffin-embedded minor salivary gland sections from SS patients, non-SS controls and healthy volunteers were analysed by immunohistochemistry. Digital image quantification was performed to evaluate the expression of BAFF, APRIL and transmembrane activator and CAML interactor. Furthermore, serum was analysed for soluble BAFF and APRIL levels by ELISA. All the data were also analysed for subjects with decreased and normal stimulated salivary flow independent of the classification. Results. APRIL expression was lower in minor salivary gland biopsies from SS patients compared with healthy volunteers and to a lesser extent non-SS controls, whereas BAFF expression was similar in all groups. Soluble APRIL levels in serum were increased in SS patients and in subjects with decreased salivary flow independent of the classification. Conclusion. APRIL salivary gland tissue levels are decreased, suggesting that targeting this cytokine locally in the salivary glands would not benefit SS patients. Moreover, the discrepancy between local and systemic levels is striking and future research should assess this in more detail. PMID:22562936

Immunoglobulin G levels during collection of large volume plasma for fractionation.

PubMed

Burkhardt, Thomas; Rothe, Remo; Moog, Rainer

2017-06-01

There is a need of comprehensive work dealing with the quality of plasma for fractionation with respect to the IgG content as today most plasma derivates are used to treat patients with immunodeficiencies and autoimmune disorders. Therefore, a prospective study was carried out to analyse IgG levels before plasmapheresis and every 200ml collected plasma. Fifty-four experienced plasmapheresis donors were recruited for subsequent 850ml plasmapheresis using the Aurora Plasmapheresis System. Donorś peripheral blood counts were analysed before and after plasmapheresis using an electronic counter. Total protein, IgG and citrate were measured turbidometrically before, during and after apheresis as well as in the plasma product. Furthermore, platelets, red and white blood cells were analysed as parameters of product quality. An average of 2751±247ml blood was processed in 47±6min. The collected plasma volume was 850±1mL and citrate consumption was 177±15mL. A continuous drop of donors' IgG level was observed during plasmapheresis. The drop was 13% of the IgG baseline value at 800mL collected plasma. Total protein, IgG and cell counts of the plasma product met current guidelines of plasma for fractionation. Donors' IgG levels during apheresis showed a steady decrease without compromising the quality of plasma product. Copyright © 2017 Elsevier Ltd. All rights reserved.

Prognostic Significance of Blood Transfusion in Newly Diagnosed Multiple Myeloma Patients without Autologous Hematopoietic Stem Cell Transplantation

PubMed Central

Fan, Liping; Fu, Danhui; Zhang, Jinping; Wang, Qingqing; Ye, Yamei; Xie, Qianling

2017-01-01

The aim of this study was to evaluate whether blood transfusions affect overall survival (OS) and progression-free survival (PFS) in newly diagnosed multiple myeloma (MM) patients without hematopoietic stem cell transplantation. A total of 181 patients were enrolled and divided into two groups: 68 patients in the transfused group and 113 patients in the nontransfused group. Statistical analyses showed that there were significant differences in ECOG scoring, Ig isotype, platelet (Plt) counts, hemoglobin (Hb) level, serum creatinine (Scr) level, and β2-microglobulin (β2-MG) level between the two groups. Univariate analyses showed that higher International Staging System staging, Plt counts < 100 × 109/L, Scr level ≥ 177 μmol/L, serum β2-MG ≥ 5.5 μmol/L, serum calcium (Ca) ≥ 2.75 mmol/L, and thalidomide use were associated with both OS and PFS in MM patients. Age ≥ 60 was associated with OS and Ig isotype was associated with PFS in MM patients. Moreover, blood transfusion was associated with PFS but not OS in MM patients. Multivariate analyses showed that blood transfusion was not an independent factor for PFS in MM patients. Our preliminary results suggested that newly diagnosed MM patients may benefit from a liberal blood transfusion strategy, since blood transfusion is not an independent impact factor for survival. PMID:28567420

Understanding genetic variation - the value of systems biology.

PubMed

Hütt, Marc-Thorsten

2014-04-01

Pharmacology is currently transformed by the vast amounts of genome-associated information available for system-level interpretation. Here I review the potential of systems biology to facilitate this interpretation, thus paving the way for the emerging field of systems pharmacology. In particular, I will show how gene regulatory and metabolic networks can serve as a framework for interpreting high throughput data and as an interface to detailed dynamical models. In addition to the established connectivity analyses of effective networks, I suggest here to also analyze higher order architectural properties of effective networks. © 2013 The British Pharmacological Society.

Wind Power Forecasting Error Frequency Analyses for Operational Power System Studies: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Florita, A.; Hodge, B. M.; Milligan, M.

2012-08-01

The examination of wind power forecasting errors is crucial for optimal unit commitment and economic dispatch of power systems with significant wind power penetrations. This scheduling process includes both renewable and nonrenewable generators, and the incorporation of wind power forecasts will become increasingly important as wind fleets constitute a larger portion of generation portfolios. This research considers the Western Wind and Solar Integration Study database of wind power forecasts and numerical actualizations. This database comprises more than 30,000 locations spread over the western United States, with a total wind power capacity of 960 GW. Error analyses for individual sites andmore » for specific balancing areas are performed using the database, quantifying the fit to theoretical distributions through goodness-of-fit metrics. Insights into wind-power forecasting error distributions are established for various levels of temporal and spatial resolution, contrasts made among the frequency distribution alternatives, and recommendations put forth for harnessing the results. Empirical data are used to produce more realistic site-level forecasts than previously employed, such that higher resolution operational studies are possible. This research feeds into a larger work of renewable integration through the links wind power forecasting has with various operational issues, such as stochastic unit commitment and flexible reserve level determination.« less

Neutral forces acting on intragenomic variability shape the Escherichia coli regulatory network topology.

PubMed

Ruths, Troy; Nakhleh, Luay

2013-05-07

Cis-regulatory networks (CRNs) play a central role in cellular decision making. Like every other biological system, CRNs undergo evolution, which shapes their properties by a combination of adaptive and nonadaptive evolutionary forces. Teasing apart these forces is an important step toward functional analyses of the different components of CRNs, designing regulatory perturbation experiments, and constructing synthetic networks. Although tests of neutrality and selection based on molecular sequence data exist, no such tests are currently available based on CRNs. In this work, we present a unique genotype model of CRNs that is grounded in a genomic context and demonstrate its use in identifying portions of the CRN with properties explainable by neutral evolutionary forces at the system, subsystem, and operon levels. We leverage our model against experimentally derived data from Escherichia coli. The results of this analysis show statistically significant and substantial neutral trends in properties previously identified as adaptive in origin--degree distribution, clustering coefficient, and motifs--within the E. coli CRN. Our model captures the tightly coupled genome-interactome of an organism and enables analyses of how evolutionary events acting at the genome level, such as mutation, and at the population level, such as genetic drift, give rise to neutral patterns that we can quantify in CRNs.

Indication of a Lombard vocal response in the St. Lawrence River beluga

NASA Astrophysics Data System (ADS)

Scheifele, P. M.; Andrew, S.; Cooper, R. A.; Darre, M.; Musiek, F. E.; Max, L.

2005-03-01

Noise pollution is recognized as a potential danger to marine mammals in general, and to the St. Lawrence beluga in particular. One method of determining the impacts of noise on an animal's communication is to observe a natural and repeatable response of the vocal system to variations in noise level. This is accomplished by observing intensity changes in animal vocalizations in response to environmental noise. One such response observed in humans, songbirds, and some primates is the Lombard vocal response. This response represents a vocal system reaction manifested by changes in vocalization level in direct response to changes in the noise field. In this research, a population of belugas in the St. Lawrence River Estuary was tested to determine whether a Lombard response existed by using hidden Markhov-classified vocalizations as targets for acoustical analyses. Correlation and regression analyses of signals and noise indicated that the phenomenon does exist. Further, results of human subjects experiments [Egan, J. J. (1966), Ph.D. dissertation; Scheifele, P. M. (2003), Ph.D. dissertation], along with previously reported data from other animal species, are similar to those exhibited by the belugas. Overall, findings suggest that typical noise levels in the St. Lawrence River Estuary have a detectable effect on the communication of the beluga. .

Reconfiguration of acute care hospitals in post-socialist Serbia: spatial distribution of hospital beds.

PubMed

Matejic, Marko

2017-04-01

In the context of healthcare reforms in post-socialist Serbia, this research analyses the reconfiguration of acute care hospitals from the aspect of the spatial distribution of hospital beds among and within state-owned hospitals. The research builds a relationship between the macro or national level and the micro or hospital level of the spatial distribution of hospital beds. The aim of the study is to point out that a high level of efficiency in hospital functionality is difficult to achieve within the current hospital network and architectural-urban patterns of hospitals, and to draw attention to the necessity of a strategically planned hospital spatial reconfiguration, conducted simultaneously with other segments of the healthcare system reform. The research analyses published and unpublished data presented in tables and diagrams. The theoretical platform of the research covers earlier discussions of the Yugoslav healthcare system, its post-socialist reforms and the experiences of developed countries. The results show that the hospital bed distribution has not undergone significant changes, while the hospital spatial reconfiguration has either not been carried out at all or, if it has, only on a small scale. All this has contributed to overall inadequate, inflexible, inefficient, defragmented and unequal bed distribution. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Mission Assessment of the Faraday Accelerator with Radio-frequency Assisted Discharge (FARAD)

NASA Technical Reports Server (NTRS)

Dankanich, John W.; Polzin, Kurt A.

2008-01-01

Pulsed inductive thrusters have typically been considered for future, high-power, missions requiring nuclear electric propulsion. These high-power systems, while promising equivalent or improved performance over state-of-the-art propulsion systems, presently have no planned missions for which they are well suited. The ability to efficiently operate an inductive thruster at lower energy and power levels may provide inductive thrusters near term applicability and mission pull. The Faraday Accelerator with Radio-frequency Assisted Discharge concept demonstrated potential for a high-efficiency, low-energy pulsed inductive thruster. The added benefits of energy recapture and/or pulse compression are shown to enhance the performance of the pulsed inductive propulsion system, yielding a system that con compete with and potentially outperform current state-of-the-art electric propulsion technologies. These enhancements lead to mission-level benefits associated with the use of a pulsed inductive thruster. Analyses of low-power near to mid-term missions and higher power far-term missions are undertaken to compare the performance of pulsed inductive thrusters with that delivered by state-of-the-art and development-level electric propulsion systems.

Implementing health management information systems: measuring success in Korea's health centers.

PubMed

Chae, Y M; Kim, S I; Lee, B H; Choi, S H; Kim, I S

1994-01-01

This article analyses the effects that the introduction and adoption of a health management information system (HMIS) can have on both the productivity of health center staff as well as on user-satisfaction. The focus is upon the service provided by the Kwonsun Health Center located in Suwon City, Korea. Two surveys were conducted to measure the changes in productivity and adoption (knowledge, persuasion, decision, implementation and confirmation) of health center staff over time. In addition, a third survey was conducted to measure the effects of HMIS on the level of satisfaction perceived by the visitors, by comparing the satisfaction level between the study health center and a similar health center identified as a control. The results suggest that HMIS increased the productivity and satisfaction of the staff but did not increase their persuasion and decision levels; and, that is also succeeded in increasing the levels of visitors' satisfaction with the services provided.

Development of water level regulation strategy for fish and wildlife, upper Mississippi River system

USGS Publications Warehouse

Lubinski, Kenneth S.; Carmody, G.; Wilcox, D.; Drazkowski, B.

1991-01-01

Water level regulation has been proposed as a tool for maintaining or enhancing fish and wildlife resources in navigation pools and associated flood plains of the Upper Mississippi River System. Research related to the development of water level management plans is being conducted under the Long Term Resource Monitoring Program. Research strategies include investigations of cause and effect relationships, spatial and temporal patterns of resource components, and alternative problem solutions. The principal hypothesis being tested states that water level fluctuations resulting from navigation dam operation create less than optimal conditions for the reproduction and growth of target aquatic macrophyte and fish species. Representative navigation pools have been selected to describe hydrologic, engineering, and legal constraints within which fish and wildlife objectives can be established. Spatial analyses are underway to predict the magnitude and location of habitat changes that will result from controlled changes in water elevation.

[Trauma and accident documentation in Germany compared with elsewhere in Europe].

PubMed

Probst, C; Richter, M; Haasper, C; Lefering, R; Otte, D; Oestern, H J; Krettek, C; Hüfner, T

2008-07-01

The role of trauma documentation has grown continuously since the 1970s. Prevention and management of injuries were adapted according to the results of many analyses. Since 1993 there have been two different trauma databases in Germany: the German trauma registry (TR) and the database of the Accident Research Unit (UFO). Modern computer applications improved the data processing. Our study analysed the pros and cons of each system and compared them with those of our European neighbours. We compared the TR and the UFO databases with respect to aims and goals, advantages and disadvantages, and current status. Results were reported as means +/- standard errors of the mean. The level of significance was set at P<0.05. There were differences between the two databases concerning number and types of items, aims and goals, and demographics. The TR documents care for severely injured patients and the clinical course of different types of accidents. The UFO describes traffic accidents, accident conditions, and interrelations. The German and British systems are similar, and the French system shows interesting differences. The German trauma documentation systems focus on different points. Therefore both can be used for substantiated analyses of different hypotheses. Certain intersections of both databases may help to answer very special questions in the future.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chevallier, J.J.; Quetier, F.P.; Marshall, D.W.

Sedco Forex has developed an integrated computer system to enhance the technical performance of the company at various operational levels and to increase the understanding and knowledge of the drill crews. This paper describes the system and how it is used for recording and processing drilling data at the rig site, for associated technical analyses, and for well design, planning, and drilling performance studies at the operational centers. Some capabilities related to the statistical analysis of the company's operational records are also described, and future development of rig computing systems for drilling applications and management tasks is discussed.

[The development of legal guardianship and involuntary treatment in a Bavarian catchment area in comparison to trends at the federal state and the federal level between 1999 and 2009].

PubMed

Valdes-Stauber, Juan; Putzhammer, Albert; Kilian, Reinhold

2011-05-01

In this study trends in legal guardianship and involuntary treatment in a Bavarian catchment area in comparison to trends at federal state and federal level between 1999 and 2009 will be examined. Data from the federal department of justice, from the federal health monitoring system and data from a district court were used to compute rates, quotas and quotients. Regression analyses were conducted to analyse associations between time series. In comparison to the federal state and the federal level the target region shows a significantly higher rate of new guardianships but a lower rate of judicial ordered mobility restrictions and at least in comparison to the federal state level a significantly lower rate of involuntary admissions according to guardianship law. The obtained differences indicate significant differences in the legal guardianship and involuntary admission practise which cannot be explained by epidemiological developments. Therefore it is necessary to investigate potential socio-cultural and socioeconomic sources for these varieties. © Georg Thieme Verlag KG Stuttgart · New York.

Atomic-level structural correlations across the morphotropic phase boundary of a ferroelectric solid solution: xBiMg 1/2Ti 1/2O 3-(1$-$x)PbTiO 3

DOE PAGES

Datta, Kaustuv; Neder, Reinhard B.; Chen, Jun; ...

2017-03-28

Revelation of unequivocal structural information at the atomic level for complex systems is uniquely important for deeper and generic understanding of the structure property connections and a key challenge in materials science. Here in this paper we report an experimental study of the local structure by applying total elastic scattering and Raman scattering analyses to an important non-relaxor ferroelectric solid solution exhibiting the so-called composition-induced morphotropic phase boundary (MPB), where concomitant enhancement of physical properties have been detected. The powerful combination of static and dynamic structural probes enabled us to derive direct correspondence between the atomic-level structural correlations and reportedmore » properties. The atomic pair distribution functions obtained from the neutron total scattering experiments were analysed through big-box atom-modelling implementing reverse Monte Carlo method, from which distributions of magnitudes and directions of off-centred cationic displacements were extracted. We found that an enhanced randomness of the displacement-directions for all ferroelectrically active cations combined with a strong dynamical coupling between the A- and B-site cations of the perovskite structure, can explain the abrupt amplification of piezoelectric response of the system near MPB. Finally, altogether this provides a more fundamental basis in inferring structure-property connections in similar systems including important implications in designing novel and bespoke materials.« less

Nurses' Use and Perception of an Information and Communication Technology System for Improving Coordination During Hospital Discharges: A Survey in Swedish Primary Healthcare.

PubMed

Christiansen, Line; Fagerström, Cecilia; Nilsson, Lina

2017-07-01

To facilitate communications between care levels and improve coordination during hospital discharges, there is great potential in using information and communication technology systems, because they can significantly help to deter unnecessary readmissions. However, there is still a lack of knowledge about how often nurses use information and communication technology and the indicators related to its use. The aims of this study were to describe the indicators related to nurses' use of an information and communication technology system for collaboration between care levels and to estimate whether the level of use can be related to nurses' perceptions of the information and communication technology system's contribution to improve coordination during hospital discharges. A quantitative survey of 37 nurses from 11 primary healthcare centers was performed in a county in southern Sweden. The data were analyzed using descriptive and comparative analyses. The results showed that perceptions concerning the information and communication technology system's usability and time consumption differed between nurses who used the system and those who did not. Simultaneously, the nurses were rather unaware of the ability of the information and communication technology system to improve coordination during patient discharges.

Systems Level Dissection of Anaerobic Methane Cycling: Quantitative Measurements of Single Cell Ecophysiology, Genetic Mechanisms, and Microbial Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orphan, Victoria; Tyson, Gene; Meile, Christof

The global biological CH4 cycle is largely controlled through coordinated and often intimate microbial interactions between archaea and bacteria, the majority of which are still unknown or have been only cursorily identified. Members of the methanotrophic archaea, aka ‘ANME’, are believed to play a major role in the cycling of methane in anoxic environments coupled to sulfate, nitrate, and possibly iron and manganese oxides, frequently forming diverse physical and metabolic partnerships with a range of bacteria. The thermodynamic challenges overcome by the ANME and their bacterial partners and corresponding slow rates of growth are common characteristics in anaerobic ecosystems, and,more » in stark contrast to most cultured microorganisms, this type of energy and resource limited microbial lifestyle is likely the norm in the environment. While we have gained an in-depth systems level understanding of fast-growing, energy-replete microorganisms, comparatively little is known about the dynamics of cell respiration, growth, protein turnover, gene expression, and energy storage in the slow-growing microbial majority. These fundamental properties, combined with the observed metabolic and symbiotic versatility of methanotrophic ANME, make these cooperative microbial systems a relevant (albeit challenging) system to study and for which to develop and optimize culture-independent methodologies, which enable a systems-level understanding of microbial interactions and metabolic networks. We used an integrative systems biology approach to study anaerobic sediment microcosms and methane-oxidizing bioreactors and expanded our understanding of the methanotrophic ANME archaea, their interactions with physically-associated bacteria, ecophysiological characteristics, and underlying genetic basis for cooperative microbial methane-oxidation linked with different terminal electron acceptors. Our approach is inherently multi-disciplinary and multi-scaled, combining transcriptional and proteomic analyses with high resolution microscopy techniques, and stable isotopic and chemical analyses that span community level ‘omics investigations (cm scale) to interspecies consortia (µm scale), to the individual cell and its subcellular components (nm scale). We have organized our methodological approach into three broad categories, RNA-based, Protein-targeted and Geochemical, each encompassing a range of scales, with many techniques and resulting datasets that are highly complementary with one another, and together, offer a unique systems-level perspective of methane-based microbial interactions.« less

Gas chromatographic analysis of trace impurities in chlorine trifluoride.

PubMed

Laurens, J B; Swinley, J M; de Coning, J P

2000-03-24

The gas chromatographic determination of trace gaseous impurities in highly reactive fluorinated gaseous matrices presents unique requirements to both equipment and techniques. Especially problematic are the gases normally present in ambient air namely oxygen and nitrogen. Analysing these gases at the low microl/l (ppm) level requires special equipment and this publication describes a custom-designed system utilising backflush column switching to protect the columns and detectors. A thermal conductivity detector with nickel filaments was used to determine ppm levels of impurities in ClF3.

Pogo summary report main propulsion test static firings 1-7 for shuttle development flight instrumentation

NASA Technical Reports Server (NTRS)

Haddick, C. M., Jr.

1980-01-01

Problems concerning the shuttle main propulsion system Polar Orbit Geophysical Observatory (POGO) instrumentation and the actions taken to correct them are summarized. Investigations and analyses appear to be providing solutions to correct the majority of questionable measurements. Corrective action in the handling of cables and connectors should increase the POGO measurement quality. Unacceptable levels of very low frequency noise and data level shifts may be related to test stand grounding configuration, but further investigation is required.

Doctors as the governing body of the Kurdish health system: exploring upward and downward accountability among physicians and its influence on the adoption of coping behaviours.

PubMed

Karadaghi, Goshan; Willott, Chris

2015-06-04

The health system of Iraqi Kurdistan is severely understudied, particularly with regard to patient-physician interactions and their effects. We examine patterns of behaviour among physicians in Kurdistan, the justifications given and possible enabling factors, with a view to understanding accountability both from above and below. An ethnographic study was conducted in the Sulaimaniyah Teaching Hospital in the Kurdistan Region of Iraq. Data was collected through negotiated interactive observation, and interviews were conducted with 10 participants, 5 physicians and 5 patients. Data collected was analysed using thematic analysis. Common patterns of practice among physicians in Kurdistan include displays of discontent, reluctance to negotiate decisions with patients and unfavourable behaviours including dual practice and predatory behaviours towards patients. These behaviours are justified as a mechanism of dealing with negative aspects of their work, including overcrowding, low salaries and social pressure to live up to socially conceived ideas of a physician's identity. Michael Lipsky's theory of street-level bureaucrats and their coping behaviours is a useful way to analyse the Kurdish health system. Physician behaviours are enabled by a number of factors that work to enhance physician discretion through lowering of upward and downward accountability. Physicians are under very little pressure to change their behaviour, and as a result, they effectively become the street-level governing body of the Kurdish health system.

Status of linear boundary-layer stability and the e to the nth method, with emphasis on swept-wing applications

NASA Technical Reports Server (NTRS)

Hefner, J. N.; Bushnell, D. M.

1980-01-01

The-state-of-the-art for the application of linear stability theory and the e to the nth power method for transition prediction and laminar flow control design are summarized, with analyses of previously published low disturbance, swept wing data presented. For any set of transition data with similar stream distrubance levels and spectra, the e to the nth power method for estimating the beginning of transition works reasonably well; however, the value of n can vary significantly, depending upon variations in disturbance field or receptivity. Where disturbance levels are high, the values of n are appreciably below the usual average value of 9 to 10 obtained for relatively low disturbance levels. It is recommended that the design of laminar flow control systems be based on conservative estimates of n and that, in considering the values of n obtained from different analytical approaches or investigations, the designer explore the various assumptions which entered into the analyses.

Comparisons of RELAP5-3D Analyses to Experimental Data from the Natural Convection Shutdown Heat Removal Test Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bucknor, Matthew; Hu, Rui; Lisowski, Darius

2016-04-17

The Reactor Cavity Cooling System (RCCS) is an important passive safety system being incorporated into the overall safety strategy for high temperature advanced reactor concepts such as the High Temperature Gas- Cooled Reactors (HTGR). The Natural Convection Shutdown Heat Removal Test Facility (NSTF) at Argonne National Laboratory (Argonne) reflects a 1/2-scale model of the primary features of one conceptual air-cooled RCCS design. The project conducts ex-vessel, passive heat removal experiments in support of Department of Energy Office of Nuclear Energy’s Advanced Reactor Technology (ART) program, while also generating data for code validation purposes. While experiments are being conducted at themore » NSTF to evaluate the feasibility of the passive RCCS, parallel modeling and simulation efforts are ongoing to support the design, fabrication, and operation of these natural convection systems. Both system-level and high fidelity computational fluid dynamics (CFD) analyses were performed to gain a complete understanding of the complex flow and heat transfer phenomena in natural convection systems. This paper provides a summary of the RELAP5-3D NSTF model development efforts and provides comparisons between simulation results and experimental data from the NSTF. Overall, the simulation results compared favorably to the experimental data, however, further analyses need to be conducted to investigate any identified differences.« less

Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure.

PubMed

Simon, Maciej J K; Beil, Frank Timo; Riedel, Christoph; Lau, Grace; Tomsia, Antoni; Zimmermann, Elizabeth A; Koehne, Till; Ueblacker, Peter; Rüther, Wolfgang; Pogoda, Pia; Ignatius, Anita; Amling, Michael; Oheim, Ralf

2016-12-01

Health risks due to chronic exposure to highly fluoridated groundwater could be underestimated because fluoride might not only influence the teeth in an aesthetic manner but also seems to led to dentoalveolar structure changes. Therefore, we studied the tooth and alveolar bone structures of Dorper sheep chronically exposed to very highly fluoridated and low calcium groundwater in the Kalahari Desert in comparison to controls consuming groundwater with low fluoride and normal calcium levels within the World Health Organization (WHO) recommended range. Two flocks of Dorper ewes in Namibia were studied. Chemical analyses of water, blood and urine were performed. Mineralized tissue investigations included radiography, HR-pQCT analyses, histomorphometry, energy-dispersive X-ray spectroscopy and X-ray diffraction-analyses. Fluoride levels were significantly elevated in water, blood and urine samples in the Kalahari group compared to the low fluoride control samples. In addition to high fluoride, low calcium levels were detected in the Kalahari water. Tooth height and mandibular bone quality were significantly decreased in sheep, exposed to very high levels of fluoride and low levels of calcium in drinking water. Particularly, bone volume and cortical thickness of the mandibular bone were significantly reduced in these sheep. The current study suggests that chronic environmental fluoride exposure with levels above the recommended limits in combination with low calcium uptake can cause significant attrition of teeth and a significant impaired mandibular bone quality. In the presence of high fluoride and low calcium-associated dental changes, deterioration of the mandibular bone and a potential alveolar bone loss needs to be considered regardless whether other signs of systemic skeletal fluorosis are observed or not.

Reusable Reentry Satellite (RRS) system design study. Phase B, appendix E: Attitude control system study

NASA Technical Reports Server (NTRS)

1991-01-01

A study which consisted of a series of design analyses for an Attitude Control System (ACS) to be incorporated into the Re-usable Re-entry Satellite (RRS) was performed. The main thrust of the study was associated with defining the control laws and estimating the mass and power requirements of the ACS needed to meet the specified performance goals. The analyses concentrated on the different on-orbit control modes which start immediately after the separation of the RRS from the launch vehicle. The three distinct on-orbit modes considered for these analyses are as follows: (1) Mode 1 - A Gravity Gradient (GG) three-axis stabilized spacecraft with active magnetic control; (2) Mode 2 - A GG stabilized mode with a controlled yaw rotation rate ('rotisserie') using three-axis magnetic control and also incorporating a 10 N-m-s momentum wheel along the (Z) yaw axis; and (3) Mode 3 - A spin stabilized mode of operation with the spin about the pitch (Y) axis, incorporating a 20 N-m-s momentum wheel along the pitch (Y) axis and attitude control via thrusters. To investigate the capabilities of the different controllers in these various operational modes, a series of computer simulations and trade-off analyses have been made to evaluate the achievable performance levels, and the necessary mass and power requirements.

Reusable Reentry Satellite (RRS) system design study. Phase B, appendix E: Attitude control system study

NASA Astrophysics Data System (ADS)

1991-02-01

A study which consisted of a series of design analyses for an Attitude Control System (ACS) to be incorporated into the Re-usable Re-entry Satellite (RRS) was performed. The main thrust of the study was associated with defining the control laws and estimating the mass and power requirements of the ACS needed to meet the specified performance goals. The analyses concentrated on the different on-orbit control modes which start immediately after the separation of the RRS from the launch vehicle. The three distinct on-orbit modes considered for these analyses are as follows: (1) Mode 1 - A Gravity Gradient (GG) three-axis stabilized spacecraft with active magnetic control; (2) Mode 2 - A GG stabilized mode with a controlled yaw rotation rate ('rotisserie') using three-axis magnetic control and also incorporating a 10 N-m-s momentum wheel along the (Z) yaw axis; and (3) Mode 3 - A spin stabilized mode of operation with the spin about the pitch (Y) axis, incorporating a 20 N-m-s momentum wheel along the pitch (Y) axis and attitude control via thrusters. To investigate the capabilities of the different controllers in these various operational modes, a series of computer simulations and trade-off analyses have been made to evaluate the achievable performance levels, and the necessary mass and power requirements.

Figure of merit studies of beam power concepts for advanced space exploration

NASA Technical Reports Server (NTRS)

Miller, Gabriel; Kadiramangalam, Murali N.

1990-01-01

Surface to surface, millimeter wavelength beam power systems for power transmission on the lunar base were investigated. Qualitative/quantitative analyses and technology assessment of 35, 110 and 140 GHz beam power systems were conducted. System characteristics including mass, stowage volume, cost and efficiency as a function of range and power level were calculated. A simple figure of merit analysis indicates that the 35 GHz system would be the preferred choice for lunar base applications, followed closely by the 110 GHz system. System parameters of a 35 GHz beam power system appropriate for power transmission on a recent lunar base concept studied by NASA-Johnson and the necessary deployment sequence are suggested.

Growth associated protein (GAP-43): cloning and the development of a sensitive ELISA for neurological disorders.

PubMed

Gnanapavan, Sharmilee; Yousaf, Nasim; Heywood, Wendy; Grant, Donna; Mills, Kevin; Chernajovsky, Yuti; Keir, Geoff; Giovannoni, Gavin

2014-11-15

GAP-43 has been studied in the rodent and mammalian brain and shown to be present specifically in areas undergoing axonal elongation and synapse formation. GAP-43 was cloned using the baculovirus expression system and purified. A sandwich ELISA was developed using the recombinant GAP-43 as standard and validated. CSF GAP-43 levels were analysed in benign intracranial hypertension, movement disorders, multiple sclerosis, neuropathy, CNS infections, motor neuron disease, and headache (neurological controls). GAP-43 levels were low in all disorders analysed (in particular motor neuron disease; p=0.001, and movement disorders and multiple sclerosis; p<0.0001) compared to controls, aside from CNS infections. GAP-43 is preferentially reduced in the CSF of neurological disorders associated with neurodegeneration. Copyright © 2014. Published by Elsevier B.V.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bozoki, G.E.; Fitzpatrick, R.G.; Bohn, M.P.

This report details the review of the Diablo Canyon Probabilistic Risk Assessment (DCPRA). The study was performed under contract from the Probabilistic Risk Analysis Branch, Office of Nuclear Reactor Research, USNRC by Brookhaven National Laboratory. The DCPRA is a full scope Level I effort and although the review touched on all aspects of the PRA, the internal events and seismic events received the vast majority of the review effort. The report includes a number of independent systems analyses sensitivity studies, importance analyses as well as conclusions on the adequacy of the DCPRA for use in the Diablo Canyon Long Termmore » Seismic Program.« less

Quantum formalism as an optimisation procedure of information flows for physical and biological systems.

PubMed

Baladrón, Carlos; Khrennikov, Andrei

2016-12-01

The similarities between biological and physical systems as respectively defined in quantum information biology (QIB) and in a Darwinian approach to quantum mechanics (DAQM) have been analysed. In both theories the processing of information is a central feature characterising the systems. The analysis highlights a mutual support on the thesis contended by each theory. On the one hand, DAQM provides a physical basis that might explain the key role played by quantum information at the macroscopic level for bio-systems in QIB. On the other hand, QIB offers the possibility, acting as a macroscopic testing ground, to analyse the emergence of quantumness from classicality in the terms held by DAQM. As an added result of the comparison, a tentative definition of quantum information in terms of classical information flows has been proposed. The quantum formalism would appear from this comparative analysis between QIB and DAQM as an optimal information scheme that would maximise the stability of biological and physical systems at any scale. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Datta, Kaustuv; Neder, Reinhard B.; Chen, Jun

Revelation of unequivocal structural information at the atomic level for complex systems is uniquely important for deeper and generic understanding of the structure property connections and a key challenge in materials science. Here in this paper we report an experimental study of the local structure by applying total elastic scattering and Raman scattering analyses to an important non-relaxor ferroelectric solid solution exhibiting the so-called composition-induced morphotropic phase boundary (MPB), where concomitant enhancement of physical properties have been detected. The powerful combination of static and dynamic structural probes enabled us to derive direct correspondence between the atomic-level structural correlations and reportedmore » properties. The atomic pair distribution functions obtained from the neutron total scattering experiments were analysed through big-box atom-modelling implementing reverse Monte Carlo method, from which distributions of magnitudes and directions of off-centred cationic displacements were extracted. We found that an enhanced randomness of the displacement-directions for all ferroelectrically active cations combined with a strong dynamical coupling between the A- and B-site cations of the perovskite structure, can explain the abrupt amplification of piezoelectric response of the system near MPB. Finally, altogether this provides a more fundamental basis in inferring structure-property connections in similar systems including important implications in designing novel and bespoke materials.« less

Sources of background light on space based laser communications links

NASA Astrophysics Data System (ADS)

Farrell, Thomas C.

2018-05-01

We discuss the sources and levels of background light that should be expected on space based laser communication (lasercom) crosslinks and uplinks, as well as on downlinks to ground stations. The analyses are valid for both Earth orbiting satellites and inter-planetary links. Fundamental equations are derived suitable for first order system engineering analyses of potential lasercom systems. These divide sources of background light into two general categories: extended sources which fill the field of view of a receiver's optics, and point sources which cannot be resolved by the optics. Specific sources of background light are discussed, and expected power levels are estimated. For uplinks, reflected sunlight and blackbody radiation from the Earth dominates. For crosslinks, depending on specific link geometry, sources of background light may include the Sun in the field of view (FOV), reflected sunlight and blackbody radiation from planets and other bodies in the solar system, individual bright stars in the FOV, the amalgam of dim stars in the FOV, zodiacal light, and reflected sunlight off of the transmitting spacecraft. For downlinks, all of these potentially come into play, and the effects of the atmosphere, including turbulence, scattering, and absorption contribute as well. Methods for accounting for each of these are presented. Specific examples are presented to illustrate the relative contributions of each source for various link geometries.

Analysing a Chinese Regional Integrated Healthcare Organisation Reform Failure using a Complex Adaptive System Approach

PubMed Central

Wei, Lai; Zhang, Liang

2017-01-01

Introduction: China’s organised health system has remained outdated for decades. Current health systems in many less market-oriented countries still adhere to traditional administrative-based directives and linear planning. Furthermore, they neglect the responsiveness and feedback of institutions and professionals, which often results in reform failure in integrated care. Complex adaptive system theory (CAS) provides a new perspective and methodology for analysing the health system and policy implementation. Methods: We observed the typical case of Qianjiang’s Integrated Health Organization Reform (IHO) for 2 years to analyse integrated care reforms using CAS theory. Via questionnaires and interviews, we observed 32 medical institutions and 344 professionals. We compared their cooperative behaviours from both organisational and inter-professional levels between 2013 and 2015, and further investigated potential reasons for why medical institutions and professionals did not form an effective IHO. We discovered how interested parties in the policy implementation process influenced reform outcome, and by theoretical induction, proposed a new semi-organised system and corresponding policy analysis flowchart that potentially suits the actual realisation of CAS. Results: The reform did not achieve its desired effect. The Qianjiang IHO was loosely integrated rather than closely integrated, and the cooperation levels between organisations and professionals were low. This disappointing result was due to low mutual trust among IHO members, with the main contributing factors being insufficient financial incentives and the lack of a common vision. Discussion and Conclusions: The traditional organised health system is old-fashioned. Rather than being completely organised or adaptive, the health system is currently more similar to a semi-organised system. Medical institutions and professionals operate in a middle ground between complete adherence to administrative orders from state-run health systems and completely adapting to the market. Thus, decision-making, implementation and analysis of health policies should also be updated according to this current standing. The simplest way to manage this new system is to abandon linear top-down orders and patiently wait for an explicit picture of IHO mechanisms to be revealed after complete and spontaneous negotiation between IHO allies is reached. In the meantime, bottom-up feedback from members should be paid attention to, and common benefits and fluid information flow should be prioritised in building a successful IHO. PMID:28970744

An integrated strategy of knowledge application for optimal e-health implementation: A multi-method study protocol

PubMed Central

Gagnon, Marie-Pierre; Légaré, France; Fortin, Jean-Paul; Lamothe, Lise; Labrecque, Michel; Duplantie, Julie

2008-01-01

Background E-health is increasingly valued for supporting: 1) access to quality health care services for all citizens; 2) information flow and exchange; 3) integrated health care services and 4) interprofessional collaboration. Nevertheless, several questions remain on the factors allowing an optimal integration of e-health in health care policies, organisations and practices. An evidence-based integrated strategy would maximise the efficacy and efficiency of e-health implementation. However, decisions regarding e-health applications are usually not evidence-based, which can lead to a sub-optimal use of these technologies. This study aims at understanding factors influencing the application of scientific knowledge for an optimal implementation of e-health in the health care system. Methods A three-year multi-method study is being conducted in the Province of Quebec (Canada). Decision-making at each decisional level (political, organisational and clinical) are analysed based on specific approaches. At the political level, critical incidents analysis is being used. This method will identify how decisions regarding the implementation of e-health could be influenced or not by scientific knowledge. Then, interviews with key-decision-makers will look at how knowledge was actually used to support their decisions, and what factors influenced its use. At the organisational level, e-health projects are being analysed as case studies in order to explore the use of scientific knowledge to support decision-making during the implementation of the technology. Interviews with promoters, managers and clinicians will be carried out in order to identify factors influencing the production and application of scientific knowledge. At the clinical level, questionnaires are being distributed to clinicians involved in e-health projects in order to analyse factors influencing knowledge application in their decision-making. Finally, a triangulation of the results will be done using mixed methodologies to allow a transversal analysis of the results at each of the decisional levels. Results This study will identify factors influencing the use of scientific evidence and other types of knowledge by decision-makers involved in planning, financing, implementing and evaluating e-health projects. Conclusion These results will be highly relevant to inform decision-makers who wish to optimise the implementation of e-health in the Quebec health care system. This study is extremely relevant given the context of major transformations in the health care system where e-health becomes a must. PMID:18435853

MODIS Information, Data, and Control System (MIDACS) system specifications and conceptual design

NASA Technical Reports Server (NTRS)

Han, D.; Salomonson, V.; Ormsby, J.; Ardanuy, P.; Mckay, A.; Hoyt, D.; Jaffin, S.; Vallette, B.; Sharts, B.; Folta, D.

1988-01-01

The MODIS Information, Data, and Control System (MIDACS) Specifications and Conceptual Design Document discusses system level requirements, the overall operating environment in which requirements must be met, and a breakdown of MIDACS into component subsystems, which include the Instrument Support Terminal, the Instrument Control Center, the Team Member Computing Facility, the Central Data Handling Facility, and the Data Archive and Distribution System. The specifications include sizing estimates for the processing and storage capacities of each data system element, as well as traffic analyses of data flows between the elements internally, and also externally across the data system interfaces. The specifications for the data system, as well as for the individual planning and scheduling, control and monitoring, data acquisition and processing, calibration and validation, and data archive and distribution components, do not yet fully specify the data system in the complete manner needed to achieve the scientific objectives of the MODIS instruments and science teams. The teams have not yet been formed; however, it was possible to develop the specifications and conceptual design based on the present concept of EosDIS, the Level-1 and Level-2 Functional Requirements Documents, the Operations Concept, and through interviews and meetings with key members of the scientific community.

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.

PubMed

Reiner, Alexander P; Hartiala, Jaana; Zeller, Tanja; Bis, Joshua C; Dupuis, Josée; Fornage, Myriam; Baumert, Jens; Kleber, Marcus E; Wild, Philipp S; Baldus, Stephan; Bielinski, Suzette J; Fontes, João D; Illig, Thomas; Keating, Brendan J; Lange, Leslie A; Ojeda, Francisco; Müller-Nurasyid, Martina; Munzel, Thomas F; Psaty, Bruce M; Rice, Kenneth; Rotter, Jerome I; Schnabel, Renate B; Tang, W H Wilson; Thorand, Barbara; Erdmann, Jeanette; Jacobs, David R; Wilson, James G; Koenig, Wolfgang; Tracy, Russell P; Blankenberg, Stefan; März, Winfried; Gross, Myron D; Benjamin, Emelia J; Hazen, Stanley L; Allayee, Hooman

2013-08-15

Increased systemic levels of myeloperoxidase (MPO) are associated with the risk of coronary artery disease (CAD). To identify the genetic factors that are associated with circulating MPO levels, we carried out a genome-wide association study (GWAS) and a gene-centric analysis in subjects of European ancestry and African Americans (AAs). A locus on chromosome 1q31.1 containing the complement factor H (CFH) gene was strongly associated with serum MPO levels in 9305 subjects of European ancestry (lead SNP rs800292; P = 4.89 × 10(-41)) and in 1690 AA subjects (rs505102; P = 1.05 × 10(-8)). Gene-centric analyses in 8335 subjects of European ancestry additionally identified two rare MPO coding sequence variants that were associated with serum MPO levels (rs28730837, P = 5.21 × 10(-12); rs35897051, P = 3.32 × 10(-8)). A GWAS for plasma MPO levels in 9260 European ancestry subjects identified a chromosome 17q22 region near MPO that was significantly associated (lead SNP rs6503905; P = 2.94 × 10(-12)), but the CFH locus did not exhibit evidence of association with plasma MPO levels. Functional analyses revealed that rs800292 was associated with levels of complement proteins in serum. Variants at chromosome 17q22 also had pleiotropic cis effects on gene expression. In a case-control analysis of ∼80 000 subjects from CARDIoGRAM, none of the identified single-nucleotide polymorphisms (SNPs) were associated with CAD. These results suggest that distinct genetic factors regulate serum and plasma MPO levels, which may have relevance for various acute and chronic inflammatory disorders. The clinical implications for CAD and a better understanding of the functional basis for the association of CFH and MPO variants with circulating MPO levels require further study.

10 best resources on power in health policy and systems in low- and middle-income countries.

PubMed

Sriram, Veena; Topp, Stephanie M; Schaaf, Marta; Mishra, Arima; Flores, Walter; Rajasulochana, Subramania Raju; Scott, Kerry

2018-05-01

Power is a critical concept to understand and transform health policy and systems. Power manifests implicitly or explicitly at multiple levels-local, national and global-and is present at each actor interface, therefore shaping all actions, processes and outcomes. Analysing and engaging with power has important potential for improving our understanding of the underlying causes of inequity, and our ability to promote transparency, accountability and fairness. However, the study and analysis of the role of power in health policy and systems, particularly in the context of low- and middle-income countries, has been lacking. In order to facilitate greater engagement with the concept of power among researchers and practitioners in the health systems and policy realm, we share a broad overview of the concept of power, and list 10 excellent resources on power in health policy and systems in low- and middle-income countries, covering exemplary frameworks, commentaries and empirical work. We undertook a two-stage process to identify these resources. First, we conducted a collaborative exercise involving crowdsourcing and participatory validation, resulting in 24 proposed articles. Second, we conducted a structured literature review in four phases, resulting in 38 articles reviewed. We present the 10 selected resources in the following categories to bring out key facets of the literature on power and health policy and systems-(1) Resources that provide an overarching conceptual exploration into how power shapes health policy and systems, and how to investigate it; and (2) examples of strong empirical work on power and health policy and systems research representing various levels of analyses, geographic regions and conceptual understandings of power. We conclude with a brief discussion of key gaps in the literature, and suggestions for additional methodological approaches to study power.

Holocene development of the eastern Gulf of Finland coastal zone (Baltic Sea)

NASA Astrophysics Data System (ADS)

Ryabchuk, Daria; Sergeev, Alexander; Gusentsova, Tatiana; Gerasimov, Dmitry; Zhamoida, Vladimir; Amantov, Aleksey; Kulkova, Marianna; Sorokin, Peter

2014-05-01

In 2011-2013 geoarcheological and marine geological research of the eastern Gulf of Finland coasts and near-shore bottom were undertaken. Researches were concentrated within several key-areas (Sestroretskaya Lowland, Narva-Luga Klint Bay and southern coastal zone of the Gulf (near Bolshaya Izhora village). Study areas can provide important information about Gulf of Finland Holocene coastal development as since Ancylus time (about 10000 cal.BP). Development of numerous sand accretion forms (spits, bars, dunes) of different shape, age and genesis caused formation of lagoon systems, situated now on-land due to land uplift. Coasts of lagoons in Sestroretskaya Lowland and Narva-Luga Klint Bay were inhabited by Neolithic and Early Metal people. Analysis of coastal morphology and results of geological research (GIS relief analyses, ground penetrating radar, drilling, grain-size analyses, radiocarbon dating) and geoarcheological studies allowed to reconstruct the mechanism of large accretion bodies (bars and spits) and lagoon systems formation during last 8000 years. Geoarcheological studies carried out within eastern Gulf of Finland coasts permitted to find some features of the Neolithic - Early Metal settlements distribution. Another important features of the eastern Gulf of Finland coastal zone relief are the series of submarine terraces found in the Gulf bottom (sea water depths 10 to 2 m). Analyses of the submarine terraces morphology and geology (e.g. grain-size distribution, pollen analyses and organic matter dating) allow to suppose that several times during Holocene (including preAncylus (11000 cal.BP) and preLittorina (8500 cal.BP) regressions) the sea-water level was lower than nowadays. During the maximal stage of the Littorina transgression (7600-7200 cal. BP) several open bays connected with the Littorina Sea appeared in this area. The lagoon systems and sand accretion bodies (spits and bars) were formed during the following decreasing of the sea level. Late Neolithic-Early Metal Epoch archaeological contexts of the end of the 6th to the beginning of the 5th ka BP mark the rate of regression. The results of geological research of submarine terraces and modeling show that by the time period about 3000 cal. BP, relative water level decreased (in the vicinities of Sestroretskaya Lowland and Bolshaya Izhora village by modern depth of about 3 m). The main trend of the final stage of paleogeographical development was the gradual relative sea-level rise up to the modern shoreline. Studies are supported by Russian Foundation for Basic Research (projects 12-05-01121 and 12-05-31196).

Modelling of Operative Report Documents for Data Integration into an openEHR-Based Enterprise Data Warehouse.

PubMed

Haarbrandt, Birger; Wilschko, Andreas; Marschollek, Michael

2016-01-01

In order to integrate operative report documents from two operating room management systems into a data warehouse, we investigated the application of the two-level modelling approach of openEHR to create a shared data model. Based on the systems' analyses, a template consisting of 13 archetypes has been developed. Of these 13 archetypes, 3 have been obtained from the international archetype repository of the openEHR foundation. The remaining 10 archetypes have been newly created. The template was evaluated by an application system expert and through conducting a first test mapping of real-world data from one of the systems. The evaluation showed that by using the two-level modelling approach of openEHR, we succeeded to represent an integrated and shared information model for operative report documents. More research is needed to learn about the limitations of this approach in other data integration scenarios.

Electrodynamic tether system study: Extended study

NASA Technical Reports Server (NTRS)

1988-01-01

This document is the final report of a study performed by Ball Space Systems Division (BSSD) for the NASA Johnson Space Center under an extension to contract NAS9-17666. The tasks for the extended study were as follows: (1) Define an interface between the Electrodynamic Tether System (ETS) and the Space Station (SS); (2) Identify growth paths for the 100 kW ETS defined in the original study to a 200 kW level of performance; (3) Quantify orbit perturbations caused by cyclic day/night operations of a Plasma Motor/Generator (PMG) on the SS and explore methods of minimizing these effects; (4) Define the analyses, precursor technology, ground tests, and precursor demonstrations leading up to a demonstration mission for an electrodynamic tether system that would be capable of producing maneuvering thrust levels of 25 newtons; and (5) Propose a development schedule for the demonstration mission and preliminary cost estimates.

Hospital non-price competition under the Global Budget Payment and Prospective Payment Systems.

PubMed

Chen, Wen-Yi; Lin, Yu-Hui

2008-06-01

This paper provides theoretical analyses of two alternative hospital payment systems for controlling medical cost: the Global Budget Payment System (GBPS) and the Prospective Payment System (PPS). The former method assigns a fixed total budget for all healthcare services over a given period with hospitals being paid on a fee-for-service basis. The latter method is usually connected with a fixed payment to hospitals within a Diagnosis-Related Group. Our results demonstrate that, given the same expenditure, the GBPS would approach optimal levels of quality and efficiency as well as the level of social welfare provided by the PPS, as long as market competition is sufficiently high; our results also demonstrate that the treadmill effect, modeling an inverse relationship between price and quantity under the GBPS, would be a quality-enhancing and efficiency-improving outcome due to market competition.

Use of GIS in visualization of work-related health problems

PubMed Central

Delaunay, M.; Van der Westhuizen, H.; Godard, V.; Agius, R.; Le Barbier, M.; Godderis, L.

2015-01-01

Background Occupational health and safety (OHS) information is often complex, diverse and unstructured and suffers from a lack of integration which usually precludes any systemic insight of the situation. Aims To analyse to what extent the use of geographical information systems (GISs) can help to integrate, analyse and present OHS data in a comprehensive and communicable way relevant for surveillance purposes. Methods We first developed a ‘macro-approach’ (from national to local level), mapping data related to economic activity (denominator of active workers displayed by activity sectors), as well as work-related ill-health (numerators of workers suffering from work-related ill-health). The latter data are composed of compensated occupational diseases on the one hand and work-related diseases investigated by specialized clinics on the other hand. Then, a ‘micro-approach’ was worked out, integrating at a plant level, using computer-aided drawing, occupational risks data and OHS surveillance data (e.g. use of medication and sickness absence data). Results At the macro-level, microelectronics companies and workers were mapped at different scales. For the first time, we were able to compare, up to the enterprise level, complementary data showing different pictures of work-related ill-health, allowing a better understanding of OH issues in this sector. At the micro-level, new information arose from the integration of risk assessment data and medical data. Conclusions This work illustrates to what extent GIS is a promising tool in the OHS field, and discusses related challenges (technical, ethical, biases and interpretation) and research perspectives. PMID:26503981

Disease Activity and Damage are not Associated with Increased Levels of Fatigue in Systemic Lupus Erythematosus Patients from LUMINA LXVII, a Multiethnic Cohort

PubMed Central

Burgos, Paula I.; Alarcón, Graciela S.; McGwin, Gerald; Crews, Kendra Q.; Reveille, John D.; Vilá, Luis M.

2009-01-01

Objective To determine the factors associated with increased levels of fatigue over the course of the disease in systemic lupus erythematosus (SLE) patients from LUMINA (Lupus in Minorities: Nature versus Nurture), a longitudinal multiethnic cohort. Methods Patients with SLE (American College of Rheumatology revised and updated criteria), age ≥16 years, disease duration ≤ 5 years at entry into the cohort (T0), of Hispanic (Texan or Puerto Rican), African America or Caucasian ethnicity, were studied. The association between socioeconomic-demographic, health behaviors, behavioral and psychological, functional and clinical characteristics and fatigue was examined using generalized estimating equations to account for the longitudinal nature of the data. Results Five-hundred and fifteen patients (~91% female) contributed 2,609 visits to these analyses; there were: 93 (18.1%) Texan Hispanics, 101 (19.6%) Puerto Rican Hispanics, 169 (32.8%) African Americans, and 152 (29.5%) Caucasians; the patients mean (SD) age and follow up time were 37.2 (12.0) and 4.7 (3.2) years, respectively. Variables associated with increased levels of fatigue in the multivariable analyses were Caucasian ethnicity, the presence of constitutional symptoms(fever, weight loss), higher levels of pain, of abnormal illness-related behaviors and of helplessness (p’s between 0.0018 and <0.0001). Conclusions The presence of pain, abnormal illness-related behaviors, helplessness and constitutional manifestations were associated with increased levels of fatigue; however, lupus specific measures, such as disease activity and damage were not. Interventions aimed at decreasing fatigue need to take into account these findings. PMID:19714612

A systems approach to accident causation in mining: an application of the HFACS method.

PubMed

Lenné, Michael G; Salmon, Paul M; Liu, Charles C; Trotter, Margaret

2012-09-01

This project aimed to provide a greater understanding of the systemic factors involved in mining accidents, and to examine those organisational and supervisory failures that are predictive of sub-standard performance at operator level. A sample of 263 significant mining incidents in Australia across 2007-2008 were analysed using the Human Factors Analysis and Classification System (HFACS). Two human factors specialists independently undertook the analysis. Incidents occurred more frequently in operations concerning the use of surface mobile equipment (38%) and working at heights (21%), however injury was more frequently associated with electrical operations and vehicles and machinery. Several HFACS categories appeared frequently: skill-based errors (64%) and violations (57%), issues with the physical environment (56%), and organisational processes (65%). Focussing on the overall system, several factors were found to predict the presence of failures in other parts of the system, including planned inappropriate operations and team resource management; inadequate supervision and team resource management; and organisational climate and inadequate supervision. It is recommended that these associations deserve greater attention in future attempts to develop accident countermeasures, although other significant associations should not be ignored. In accordance with findings from previous HFACS-based analyses of aviation and medical incidents, efforts to reduce the frequency of unsafe acts or operations should be directed to a few critical HFACS categories at the higher levels: organisational climate, planned inadequate operations, and inadequate supervision. While remedial strategies are proposed it is important that future efforts evaluate the utility of the measures proposed in studies of system safety. Copyright © 2011. Published by Elsevier Ltd.

AEOSS runtime manual for system analysis on Advanced Earth-Orbital Spacecraft Systems

NASA Technical Reports Server (NTRS)

Lee, Hwa-Ping

1990-01-01

Advanced earth orbital spacecraft system (AEOSS) enables users to project the required power, weight, and cost for a generic earth-orbital spacecraft system. These variables are calculated on the component and subsystem levels, and then the system level. The included six subsystems are electric power, thermal control, structure, auxiliary propulsion, attitude control, and communication, command, and data handling. The costs are computed using statistically determined models that were derived from the flown spacecraft in the past and were categorized into classes according to their functions and structural complexity. Selected design and performance analyses for essential components and subsystems are also provided. AEOSS has the feature permitting a user to enter known values of these parameters, totally and partially, at all levels. All information is of vital importance to project managers of subsystems or a spacecraft system. AEOSS is a specially tailored software coded from the relational database program of the Acius' 4th Dimension with a Macintosh version. Because of the licensing agreements, two versions of the AEOSS documents were prepared. This version, AEOSS Runtime Manual, is permitted to be distributed with a finite number of the restrictive 4D Runtime version. It can perform all contained applications without any programming alterations.

Institutional and Structural Barriers to Latino/a Achievement

ERIC Educational Resources Information Center

Valenzuela, Angela; Garcia, Emmanuel; Romo, Harriett; Perez, Beatrix

2012-01-01

The problem of low academic attainment for Latino/a students may be a result of the situation at the K-12 levels, a situation that is beyond the control of students or their families (Martinez, 2003). Analyses of school success must take into account the social and political hierarchies in schools, school systems, and communities, as well as the…

The International, Global and Intercultural Dimensions in Schools: An Analysis of Four Internationalised Israeli Schools

ERIC Educational Resources Information Center

Yemini, Miri; Fulop, Alexandra

2015-01-01

Many educational systems worldwide are making substantial efforts to integrate an international dimension into local schools, fostering significant changes in the processes of instruction and learning as well as transformations at pedagogical and organisational levels. In this paper, we analyse data collected in four schools in Israel that the…

Adapting biomarker technologies to adverse outcome pathways (AOPs) research: current thoughts on using in vivo discovery for developing in vitro target methods

EPA Science Inventory

Adverse outcome pathways (AOP) research is a relatively new concept in human systems biology for assessing the molecular level linkage from an initiating (chemical) event that could lead to a disease state. Although most implementations of AOPs are based on liquids analyses, the...

The University Library and the Doctoral Dissertation in Professional Education: A Case Study.

ERIC Educational Resources Information Center

Counelis, James Steve

This case study provides both systemic and systematic analyses of the university library's role in the knowledge transmission function and doctoral-level research needs in professional education. Based on a self-study of the School of Education (with five doctoral programs) and two university libraries at the University of San Francisco, the…

Concept Maps as a Tool to Analyse College Students' Knowledge of Geospatial Concepts

ERIC Educational Resources Information Center

Oda, Katsuhiko

2016-01-01

This study focused on college students' development of conceptual knowledge in geographic information system (GIS). The aim of this study was to examine if and how students developed their conceptual knowledge during their enrollment in an introductory-level GIS course. Twelve undergraduate students constructed 36 concept maps and revised 24…

The Retreat from Widening Participation? The National Scholarship Programme and New Access Agreements in English Higher Education

ERIC Educational Resources Information Center

McCaig, Colin

2016-01-01

This article critically analyses the impact of reforms to the student financial support system in English higher education. Comparative analysis of financial support mechanisms and patterns of outreach engagement with groups underrepresented in higher education show a marked deterioration in the levels of cash support available and an increasingly…

Prospective Elementary Science Teachers' Understanding of Photosynthesis and Cellular Respiration in the Context of Multiple Biological Levels as Nested Systems

ERIC Educational Resources Information Center

Akçay, Süleyman

2017-01-01

In this study, Turkish prospective elementary science teachers' understanding of photosynthesis and cellular respiration has been analysed within the contexts of ecosystem knowledge, organism knowledge and interconnection knowledge (IK). In the analysis, concept maps developed by 74 prospective teachers were used. The study was carried out with…

Developmental and Individual Differences in Chinese Writing

ERIC Educational Resources Information Center

Guan, Connie Qun; Ye, Feifei; Wagner, Richard K.; Meng, Wanjin

2013-01-01

The goal of the present study was to examine the generalizability of a model of the underlying dimensions of written composition across writing systems (Chinese Mandarin vs. English) and level of writing skill. A five-factor model of writing originally developed from analyses of 1st and 4th grade English writing samples was applied to Chinese…

Human Capital--Economic Growth Nexus in the Former Soviet Bloc

ERIC Educational Resources Information Center

Osipian, Ararat L.

2007-01-01

This study analyses the role and impact of higher education on per capita economic growth in the Former Soviet Bloc. It attempts to estimate the significance of educational levels for initiating substantial economic growth that now takes place in these two countries. This study estimates a system of linear and log-linear equations that account for…

Online Courses Assessment through Measuring and Archetyping of Usage Data

ERIC Educational Resources Information Center

Kazanidis, Ioannis; Theodosiou, Theodosios; Petasakis, Ioannis; Valsamidis, Stavros

2016-01-01

Database files and additional log files of Learning Management Systems (LMSs) contain an enormous volume of data which usually remain unexploited. A new methodology is proposed in order to analyse these data both on the level of both the courses and the learners. Specifically, "regression analysis" is proposed as a first step in the…

Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins.

PubMed

Korneli, Claudia; David, Florian; Biedendieck, Rebekka; Jahn, Dieter; Wittmann, Christoph

2013-01-20

The high industrial relevance of the soil bacterium Bacillus megaterium as host for recombinant proteins is driving systems-wide analyses of its metabolic and regulatory networks. The present review highlights novel systems biology tools available to unravel the various cellular components on the level of metabolic and regulatory networks. These provide a rational platform for systems metabolic engineering of B. megaterium. In line, a number of interesting studies have particularly focused on studying recombinant B. megaterium in its industrial bioprocess environment thus integrating systems metabolic engineering with systems biotechnology and providing the full picture toward optimal processes. Copyright © 2012 Elsevier B.V. All rights reserved.

Single walled boron nitride nanotube-based biosensor: an atomistic finite element modelling approach.

PubMed

Panchal, Mitesh B; Upadhyay, Sanjay H

2014-09-01

The unprecedented dynamic characteristics of nanoelectromechanical systems make them suitable for nanoscale mass sensing applications. Owing to superior biocompatibility, boron nitride nanotubes (BNNTs) are being increasingly used for such applications. In this study, the feasibility of single walled BNNT (SWBNNT)-based bio-sensor has been explored. Molecular structural mechanics-based finite element (FE) modelling approach has been used to analyse the dynamic behaviour of SWBNNT-based biosensors. The application of an SWBNNT-based mass sensing for zeptogram level of mass has been reported. Also, the effect of size of the nanotube in terms of length as well as different chiral atomic structures of SWBNNT has been analysed for their sensitivity analysis. The vibrational behaviour of SWBNNT has been analysed for higher-order modes of vibrations to identify the intermediate landing position of biological object of zeptogram scale. The present molecular structural mechanics-based FE modelling approach is found to be very effectual to incorporate different chiralities of the atomic structures. Also, different boundary conditions can be effectively simulated using the present approach to analyse the dynamic behaviour of the SWBNNT-based mass sensor. The presented study has explored the potential of SWBNNT, as a nanobiosensor having the capability of zeptogram level mass sensing.

Catchment scale water resource constraints on UK policies for low-carbon energy system transition

NASA Astrophysics Data System (ADS)

Konadu, D. D.; Fenner, R. A.

2017-12-01

Long-term low-carbon energy transition policy of the UK presents national scale propositions of different low-carbon energy system options that lead to meeting GHG emissions reduction target of 80% on 1990 levels by 2050. Whilst national-scale assessments suggests that water availability may not be a significant constrain on future thermal power generation systems in this pursuit, these analysis fail to capture the appropriate spatial scale where water resource decisions are made, i.e. at the catchment scale. Water is a local resource, which also has significant spatio-temporal regional and national variability, thus any policy-relevant water-energy nexus analysis must be reflective of these characteristics. This presents a critical challenge for policy relevant water-energy nexus analysis. This study seeks to overcome the above challenge by using a linear spatial-downscaling model to allocate nationally projected water-intensive energy system infrastructure/technologies to the catchment level, and estimating the water requirements for the deployment of these technologies. The model is applied to the UK Committee on Climate Change Carbon Budgets to 2030 as a case study. The paper concludes that whilst national-scale analyses show minimal long-term water related impacts, catchment level appraisal of water resource requirements reveal significant constraints in some locations. The approach and results presented in this study thus, highlights the importance of bringing together scientific understanding, data and analysis tools to provide better insights for water-energy nexus decisions at the appropriate spatial scale. This is particularly important for water stressed regions where the water-energy nexus must be analysed at appropriate spatial resolution to capture the full water resource impact of national energy policy.

Flight evaluation of Spacelab 1 payload thermal/ECS interfaces

NASA Technical Reports Server (NTRS)

Ray, C. D.; Humphries, W. R.; Patterson, W. C.

1984-01-01

The Spacelab (SL-1) thermal/Environmental Control Systems (ECS) are discussed. Preflight analyses and flight data are compared in order to validate payload to Spacelab interfaces as well as corroborate modeling/analysis techniques. In doing so, a brief description of the Spacelab 1 payload configuration and the interactive Spacelab thermal/ECS systems are given. In particular, these interfaces address equipment cooling air, thermal and fluid conditions, humidity levels, both freon and water loop temperatures and load states, as well as passive radiant environment interfaces.

Improving Common Security Risk Analysis (Amelioration d’un processus commun d’analyse de risques securite)

DTIC Science & Technology

2008-09-01

publication has been reproduced directly from material supplied by RTO or the authors. Published September 2008 Copyright © RTO/NATO 2008 All Rights...requirements are met at each level within the composed system, a chain of belief is formed which provides assurance that the composed system is in...FAILURE OF AIR-CONDITIONING x 12 – LOSS OF POWER SUPPLY x 13 – FAILURE OF TELECOMMUNICATION EQUIPMENT x 4 – Disturbance Due to

Analysing a Chinese Regional Integrated Healthcare Organisation Reform Failure using a Complex Adaptive System Approach.

PubMed

Tang, Wenxi; Wei, Lai; Zhang, Liang

2017-06-19

China's organised health system has remained outdated for decades. Current health systems in many less market-oriented countries still adhere to traditional administrative-based directives and linear planning. Furthermore, they neglect the responsiveness and feedback of institutions and professionals, which often results in reform failure in integrated care. Complex adaptive system theory (CAS) provides a new perspective and methodology for analysing the health system and policy implementation. We observed the typical case of Qianjiang's Integrated Health Organization Reform (IHO) for 2 years to analyse integrated care reforms using CAS theory. Via questionnaires and interviews, we observed 32 medical institutions and 344 professionals. We compared their cooperative behaviours from both organisational and inter-professional levels between 2013 and 2015, and further investigated potential reasons for why medical institutions and professionals did not form an effective IHO. We discovered how interested parties in the policy implementation process influenced reform outcome, and by theoretical induction, proposed a new semi-organised system and corresponding policy analysis flowchart that potentially suits the actual realisation of CAS. The reform did not achieve its desired effect. The Qianjiang IHO was loosely integrated rather than closely integrated, and the cooperation levels between organisations and professionals were low. This disappointing result was due to low mutual trust among IHO members, with the main contributing factors being insufficient financial incentives and the lack of a common vision. The traditional organised health system is old-fashioned. Rather than being completely organised or adaptive, the health system is currently more similar to a semi-organised syste m. Medical institutions and professionals operate in a middle ground between complete adherence to administrative orders from state-run health systems and completely adapting to the market. Thus, decision-making, implementation and analysis of health policies should also be updated according to this current standing. The simplest way to manage this new system is to abandon linear top-down orders and patiently wait for an explicit picture of IHO mechanisms to be revealed after complete and spontaneous negotiation between IHO allies is reached. In the meantime, bottom-up feedback from members should be paid attention to, and common benefits and fluid information flow should be prioritised in building a successful IHO.

Livelihood diversification in tropical coastal communities: a network-based approach to analyzing 'livelihood landscapes'.

PubMed

Cinner, Joshua E; Bodin, Orjan

2010-08-11

Diverse livelihood portfolios are frequently viewed as a critical component of household economies in developing countries. Within the context of natural resources governance in particular, the capacity of individual households to engage in multiple occupations has been shown to influence important issues such as whether fishers would exit a declining fishery, how people react to policy, the types of resource management systems that may be applicable, and other decisions about natural resource use. This paper uses network analysis to provide a novel methodological framework for detailed systemic analysis of household livelihood portfolios. Paying particular attention to the role of natural resource-based occupations such as fisheries, we use network analyses to map occupations and their interrelationships- what we refer to as 'livelihood landscapes'. This network approach allows for the visualization of complex information about dependence on natural resources that can be aggregated at different scales. We then examine how the role of natural resource-based occupations changes along spectra of socioeconomic development and population density in 27 communities in 5 western Indian Ocean countries. Network statistics, including in- and out-degree centrality, the density of the network, and the level of network centralization are compared along a multivariate index of community-level socioeconomic development and a gradient of human population density. The combination of network analyses suggests an increase in household-level specialization with development for most occupational sectors, including fishing and farming, but that at the community-level, economies remained diversified. The novel modeling approach introduced here provides for various types of livelihood portfolio analyses at different scales of social aggregation. Our livelihood landscapes approach provides insights into communities' dependencies and usages of natural resources, and shows how patterns of occupational interrelationships relate to socioeconomic development and population density. A key question for future analysis is how the reduction of household occupational diversity, but maintenance of community diversity we see with increasing socioeconomic development influences key aspects of societies' vulnerability to environmental change or disasters.

Are there differences in health information exchange by health system type?

PubMed

Opoku-Agyeman, William; Menachemi, Nir

2016-01-01

Despite the potential of health information exchange (HIE) to improve safety and reduce cost, hospitals have been slow to adopt HIE with only 30% of U.S. hospitals doing so in 2012. The aim of this study was to explore the relationship between different health system types and how they engage in HIE. Data on health system types and engagement in HIE activity were combined with secondary hospital characteristics. Ordinal logistic regression analyses were used to examine the relationship between a scale measuring the level of HIE engagement and health system type controlling for hospital and market characteristics. Data from 1552 hospitals were available for analyses. Overall, hospital in a health system of any kind exchanged more patient data elements (e.g., patient demographics, clinical summaries, laboratory results, medication history, and radiology report) compared with stand-alone hospitals (3.82 vs. 1.80, p < .001). Overall, 62.2% of hospitals were part of a health system, and among system hospitals, 125 (8.0%) were in centralized health systems, 75 (4.8%) were in centralized physician/insurance health system, 284 (18.3%) were in moderately centralized health system, 391 (25.2%) were in decentralized health system, and 91 (5.9%) were in independent health system. In regression analyses, hospitals belonging to a health system were more likely to exchange patient health data with other hospitals in the same system (OR = 3.94, p < .001) but not with hospitals outside their system (OR = 1.89, p = .445). Across health system types, there was no significant difference in the exchange of patient health data. Hospital engagement in HIE is associated with health system membership. These findings will assist hospital leaders and managers to better understand how the structure and nature of their system may influence what their individual hospital can and cannot do in their decision to engage in HIE and other decisions that support the overall system objectives.

The Religiosity/Spirituality of Latina Breast Cancer Survivors and Influence on Health-Related Quality of Life

PubMed Central

Wildes, Kimberly A.; Miller, Alexander R.; de Majors, Sandra San Miguel; Ramirez, Amelie G.

2010-01-01

Objective The study evaluated the association of religiosity/spirituality (R/S) and health-related quality of life (HRQOL) among Latina breast cancer survivors (BCS) in order to determine whether R/S would be positively correlated with HRQOL and whether R/S would significantly influence HRQOL. Methods The cross-sectional study utilized self-report data from 117 Latina BCS survivors. R/S was measured with the Systems of Belief Inventory - 15 Revised (SBI-15R) and HRQOL was measured with the Functional Assessment of Cancer Therapy – General (FACT-G). Analyses included calculation of descriptive statistics, t-tests, bivariate correlations, and multivariate analyses. Results Latina BCS had very high levels of R/S and generally good HRQOL. The SBI-15R total score was positively correlated with FACT-G social well-being (r=0.266, p=0.005), relationship with doctor (r=0.219, p=0.020), and functional well-being (r=0.216, p=0.022). Multivariate analyses revealed that SBI-15R was a significant predictor of FACT-G functional well-being (p=0.041) and satisfaction with the relationship with the doctor (p=0.050), where higher levels of R/S predicted higher levels of well-being. Conclusions Latina BCS had very high levels of R/S, which were significantly, positively correlated with dimensions of HRQOL (social well-being, functional well-being, relationship with doctor). Further, these high levels of R/S predicted better functional well-being and satisfaction with the patient-doctor relationship while controlling for potentially confounding variables. Implications are discussed. PMID:19034922

Geographic information system as country-level development and monitoring tool, Senegal example

USGS Publications Warehouse

Moore, Donald G.; Howard, Stephen M.; ,

1990-01-01

Geographic information systems (GIS) allow an investigator the capability to merge and analyze numerous types of country-level resource data. Hypothetical resource analysis applications in Senegal were conducted to illustrate the utility of a GIS for development planning and resource monitoring. Map and attribute data for soils, vegetation, population, infrastructure, and administrative units were merged to form a database within a GIS. Several models were implemented using a GIS to: analyze development potential for sustainable dryland agriculture; prioritize where agricultural development should occur based upon a regional food budget; and monitor dynamic events with remote sensing. The steps for implementing a GIS analysis are described and illustrated, and the use of a GIS for conducting an economic analysis is outlined. Using a GIS for analysis and display of results opens new methods of communication between resource scientists and decision makers. Analyses yielding country-wide map output and detailed statistical data for each level of administration provide the advantage of a single system that can serve a variety of users.

Steroids in house sparrows (Passer domesticus): Effects of POPs and male quality signalling.

PubMed

Nossen, Ida; Ciesielski, Tomasz M; Dimmen, Malene V; Jensen, Henrik; Ringsby, Thor Harald; Polder, Anuschka; Rønning, Bernt; Jenssen, Bjørn M; Styrishave, Bjarne

2016-03-15

At high trophic levels, environmental contaminants have been found to affect endocrinological processes. Less attention has been paid to species at lower trophic levels. The house sparrow (Passer domesticus) may be a useful model for investigating effects of POPs in mid-range trophic level species. In male house sparrows, ornamental traits involved in male quality signalling are important for female selection. These traits are governed by endocrinological systems, and POPs may therefore interfere with male quality signalling. The aim of the present study was to use the house sparrow as a mid-range trophic level model species to study the effects of environmental contaminants on endocrinology and male quality signalling. We analysed the levels of selected PCBs, PBDEs and OCPs and investigated the possible effects of these contaminants on circulating levels of steroid hormones (4 progestagens, 4 androgens and 3 estrogens) in male and female adult house sparrows from a population on the island Leka, Norway. Plasma samples were analysed for steroid hormones by GC-MS and liver samples were analysed for environmental contaminants by GC-ECD and GC-MS. In males, we also quantified ornament traits. It was hypothesised that POPs may have endocrine disrupting effects on the local house sparrow population and can thus interfere with the steroid hormone homeostasis. Among female house sparrows, bivariate correlations revealed negative relationships between POPs and estrogens. Among male sparrows, positive relationships between dihydrotestosterone levels and PCBs were observed. In males, positive relationships were also found between steroids and beak length, and between steroids and ornamental traits such as total badge size. This was confirmed by a significant OPLS model between beak length and steroids. Although sparrows are in the mid-range trophic levels, the present study indicates that POPs may affect steroid homeostasis in house sparrows, in particular for females. For males, circulating steroid levels appears to be more associated with biometric parameters related to ornamental traits. Copyright © 2015 Elsevier B.V. All rights reserved.

Genetic variability of HEV isolates: inconsistencies of current classification.

PubMed

Oliveira-Filho, Edmilson F; König, Matthias; Thiel, Heinz-Jürgen

2013-07-26

Many HEV and HEV-like sequences have been reported during the last years, including isolates which may represent a number of potential new genera, new genotypes or new subtypes within the family Hepeviridae. Using the most common classification system, difficulties in the establishment of subtypes have been reported. Moreover the relevance of subtype classification for epidemiology can be questioned. In this study we have performed phylogenetic analyses based on whole capsid gene and complete HEV genomic sequences in order to evaluate the current classification of HEV at genotype and subtype levels. The results of our analyses modify the current taxonomy of genotype 3 and refine the established system for typing of HEV. In addition we suggest a classification for hepeviruses recently isolated from bats, ferrets, rats and wild boar. Copyright © 2013 Elsevier B.V. All rights reserved.

Aircraft Structural Mass Property Prediction Using Conceptual-Level Structural Analysis

NASA Technical Reports Server (NTRS)

Sexstone, Matthew G.

1998-01-01

This paper describes a methodology that extends the use of the Equivalent LAminated Plate Solution (ELAPS) structural analysis code from conceptual-level aircraft structural analysis to conceptual-level aircraft mass property analysis. Mass property analysis in aircraft structures has historically depended upon parametric weight equations at the conceptual design level and Finite Element Analysis (FEA) at the detailed design level. ELAPS allows for the modeling of detailed geometry, metallic and composite materials, and non-structural mass coupled with analytical structural sizing to produce high-fidelity mass property analyses representing fully configured vehicles early in the design process. This capability is especially valuable for unusual configuration and advanced concept development where existing parametric weight equations are inapplicable and FEA is too time consuming for conceptual design. This paper contrasts the use of ELAPS relative to empirical weight equations and FEA. ELAPS modeling techniques are described and the ELAPS-based mass property analysis process is detailed. Examples of mass property stochastic calculations produced during a recent systems study are provided. This study involved the analysis of three remotely piloted aircraft required to carry scientific payloads to very high altitudes at subsonic speeds. Due to the extreme nature of this high-altitude flight regime, few existing vehicle designs are available for use in performance and weight prediction. ELAPS was employed within a concurrent engineering analysis process that simultaneously produces aerodynamic, structural, and static aeroelastic results for input to aircraft performance analyses. The ELAPS models produced for each concept were also used to provide stochastic analyses of wing structural mass properties. The results of this effort indicate that ELAPS is an efficient means to conduct multidisciplinary trade studies at the conceptual design level.

Aircraft Structural Mass Property Prediction Using Conceptual-Level Structural Analysis

NASA Technical Reports Server (NTRS)

Sexstone, Matthew G.

1998-01-01

This paper describes a methodology that extends the use of the Equivalent LAminated Plate Solution (ELAPS) structural analysis code from conceptual-level aircraft structural analysis to conceptual-level aircraft mass property analysis. Mass property analysis in aircraft structures has historically depended upon parametric weight equations at the conceptual design level and Finite Element Analysis (FEA) at the detailed design level ELAPS allows for the modeling of detailed geometry, metallic and composite materials, and non-structural mass coupled with analytical structural sizing to produce high-fidelity mass property analyses representing fully configured vehicles early in the design process. This capability is especially valuable for unusual configuration and advanced concept development where existing parametric weight equations are inapplicable and FEA is too time consuming for conceptual design. This paper contrasts the use of ELAPS relative to empirical weight equations and FEA. ELAPS modeling techniques are described and the ELAPS-based mass property analysis process is detailed Examples of mass property stochastic calculations produced during a recent systems study are provided This study involved the analysis of three remotely piloted aircraft required to carry scientific payloads to very high altitudes at subsonic speeds. Due to the extreme nature of this high-altitude flight regime,few existing vehicle designs are available for use in performance and weight prediction. ELAPS was employed within a concurrent engineering analysis process that simultaneously produces aerodynamic, structural, and static aeroelastic results for input to aircraft performance analyses. The ELAPS models produced for each concept were also used to provide stochastic analyses of wing structural mass properties. The results of this effort indicate that ELAPS is an efficient means to conduct multidisciplinary trade studies at the conceptual design level.

High Precision Isotope Analyses Using Multi-Collector SIMS: Applications to Earth and Planetary Science.

NASA Astrophysics Data System (ADS)

Kita, N. T.; Ushikubo, T.; Valley, J. W.

2008-05-01

The CAMECA IMS-1280 large radius, multicollector ion microprobe at the Wisc-SIMS National Facility is capable of high accuracy and precision for in situ analysis of isotope ratios. With improved hardware stability and software capability, high precision isotope analyses are routinely performed, typically 5 min per spot. We have developed analytical protocols for stable isotope analyses of oxygen, carbon, Mg, Si and Sulfur using multi-collector Faraday Cups (MCFC) and achieved precision of 0.1-0.2 ‰ (1SD) from a typically 10μm spot analyses. A number of isotopically homogeneous mineral standards have been prepared and calibrated in order to certify the accuracy of analyses in the same level. When spatial resolution is critical, spot size is reduced down to sub- μm for δ 18O to obtain better than 0.5‰ (1SD) precision by using electron multiplier (EM) on multi-collection system. Multi-collection EM analysis is also applied at 10 ppm level to Li isotope ratios in zircon with precision better than 2‰ (1SD). A few applications will be presented. (1) Oxygen three isotope analyses of chondrules in ordinary chondrites revealed both mass dependent and mass independent oxygen isotope fractionations among chondrules as well as within individual chondrules. The results give constraints on the process of chondrule formation and origin of isotope reservoirs in the early solar system. (2) High precision 26Al-26Mg (half life of 0.73 Ma) chronology is applied to zoned melilite and anorthite from Ca, Al-rich inclusions (CAI) in Leoville meteorite, and a well-defined internal isochron is obtained. The results indicate the Al- Mg system was remained closed within 40ky of the crystallization of melilite and anorthite in this CAI. (3) Sub- μm spot analyses of δ18O in isotopically zoned zircon from high-grade metamorphism reveals a diffusion profile of ~6‰ over 2μm, indicating slow diffusion of oxygen in zircon. This result also implies that old Archean detrital zircons (> 4Ga) might preserve their primary oxygen isotopic records, which allows us to trace the geological processes of the early earth [1]. Lithium isotope analyses of pre- 4Ga zircon from Jack Hills show high Li abundance and low δ 7Li, indicating existence of highly weathered crustal material as early as 4.3Ga. In conclusion, these new techniques allow us to study small natural variations of stable isotopes at μm-scale that permit exciting and fundamental research where samples are small, precious, or zoned. [1] Page FZ et al. (2007) Am Min 92, 1772-1775.

[Met-enkephalin in the cerebrospinal fluid as an indicator of central nervous system injury in meningitis and encephalitis].

PubMed

Cieśla, Andrzej; Pierzchała-Koziec, Krystyna; Mach, Tomasz; Garlicki, Aleksander; Bociaga-Jasik, Monika

2005-05-01

Assessment of met-enkephalin level in the cerebrospinal fluid (CSF) of patients with inflammatory process of the central nervous system (CNS) was performed to estimate the role of opioid system in viral and bacterial meningitis, and encephalitis. The met-enkephalin level, protein concentration and pleocytosis were analysed in the CSF of 53 patients with viral or bacterial meningitis, encephalitis, and in the control group of patients without inflammatory disease of the CNS. The biggest differences have been observed between the groups of patients with bacterial meningitis and those without inflammatory disease of the CNS, but they were statistically insignificant. There was a lack of correlation between met-enkephalin level and some factors of inflammatory process in CSF, such as pleocytosis and protein concentration. We have not revealed any correlation between etiological agent of CNS infection and opioid system of the brain. Despite the fact that, we observed in the study statistically insignificant changes, we suggest to continue investigations, including additional parameters which are characteristic for the CNS diseases.

Predictors and Extent of Institutional Trust in Government, Banks, the Media and Religious Organisations: Evidence from Cross-Sectional Surveys in Six Asia-Pacific Countries.

PubMed

Ward, Paul R; Miller, Emma; Pearce, Alex R; Meyer, Samantha B

2016-01-01

Building or maintaining institutional trust is of central importance in democratic societies since negative experiences (potentially leading to mistrust) with government or other institutions may have a much more profound effect than positive experiences (potentially maintaining trust). Healthy democracy relies on more than simply trusting the national government of the time, and is mediated through other symbols of institutional power, such as the legal system, banks, the media and religious organisations. This paper focuses on institutional trust-the level and predictors of trust in some of the major institutions in society, namely politics, the media, banks, the legal system and religious organisations. We present analyses from a consolidated dataset containing data from six countries in the Asia Pacific region-Australia, Hong Kong, Japan, South Korea, Taiwan and Thailand. Cross-sectional surveys were undertaken in each country in 2009-10, with an overall sample of 6331. Analyses of differences in overall levels of institutional trust between countries were undertaken using Chi square analyses. Multivariate binomial logistic regression analysis was undertaken to identify socio-demographic predictors of trust in each country. Religious institutions, banks and the judicial system had the highest overall trust across all countries (70%, 70% and 67% respectively), followed by newspapers and TV (59% and 58%) and then political leaders (43%). The range of levels of higher trust between countries differed from 43% for banks (range 49% in Australia to 92% in Thailand) to 59% for newspapers (28% in Australia to 87% in Japan). Across all countries, except for Australia, trust in political leaders had the lowest scores, particularly in Japan and South Korea (25% in both countries). In Thailand, people expressed the most trust in religious organisations (94%), banks (92%) and in their judicial/legal system (89%). In Hong Kong, people expressed the highest level of trust in their judicial/legal system (89%), followed by religious organisations (75%) and banks (77%). Australian respondents reported the least amount of trust in TV/media (24%) and press/newspapers (28%). South Korea put the least trust in their political leaders (25%), their legal system (43%) and religious organisations (45%). The key predictors of lower trust in institutions across all countries were males, people under 44 years and people unsatisfied with the health and standard of living. We interpreted our data using Fukuyama's theory of 'high/low trust' societies. The levels of institutional trust in each society did not conform to our hypothesis, with Thailand exhibiting the highest trust (predicted to be medium level), Hong Kong and Japan exhibiting medium trust (predicted to be low and high respectively) and Australia and South Korea exhibiting low trust (predicted to be high and medium respectively). Taiwan was the only country where the actual and predicted trust was the same, namely low trust. Given the fact that these predictors crossed national boundaries and institutional types, further research and policy should focus specifically on improving trust within these groups in order that they can be empowered to play a more central role in democratic vitality.

Predictors and Extent of Institutional Trust in Government, Banks, the Media and Religious Organisations: Evidence from Cross-Sectional Surveys in Six Asia-Pacific Countries

PubMed Central

Miller, Emma; Pearce, Alex R.; Meyer, Samantha B.

2016-01-01

Background Building or maintaining institutional trust is of central importance in democratic societies since negative experiences (potentially leading to mistrust) with government or other institutions may have a much more profound effect than positive experiences (potentially maintaining trust). Healthy democracy relies on more than simply trusting the national government of the time, and is mediated through other symbols of institutional power, such as the legal system, banks, the media and religious organisations. This paper focuses on institutional trust–the level and predictors of trust in some of the major institutions in society, namely politics, the media, banks, the legal system and religious organisations. We present analyses from a consolidated dataset containing data from six countries in the Asia Pacific region–Australia, Hong Kong, Japan, South Korea, Taiwan and Thailand. Methods Cross-sectional surveys were undertaken in each country in 2009–10, with an overall sample of 6331. Analyses of differences in overall levels of institutional trust between countries were undertaken using Chi square analyses. Multivariate binomial logistic regression analysis was undertaken to identify socio-demographic predictors of trust in each country. Results Religious institutions, banks and the judicial system had the highest overall trust across all countries (70%, 70% and 67% respectively), followed by newspapers and TV (59% and 58%) and then political leaders (43%). The range of levels of higher trust between countries differed from 43% for banks (range 49% in Australia to 92% in Thailand) to 59% for newspapers (28% in Australia to 87% in Japan). Across all countries, except for Australia, trust in political leaders had the lowest scores, particularly in Japan and South Korea (25% in both countries). In Thailand, people expressed the most trust in religious organisations (94%), banks (92%) and in their judicial/legal system (89%). In Hong Kong, people expressed the highest level of trust in their judicial/legal system (89%), followed by religious organisations (75%) and banks (77%). Australian respondents reported the least amount of trust in TV/media (24%) and press/newspapers (28%). South Korea put the least trust in their political leaders (25%), their legal system (43%) and religious organisations (45%). The key predictors of lower trust in institutions across all countries were males, people under 44 years and people unsatisfied with the health and standard of living. Conclusion We interpreted our data using Fukuyama’s theory of ‘high/low trust’ societies. The levels of institutional trust in each society did not conform to our hypothesis, with Thailand exhibiting the highest trust (predicted to be medium level), Hong Kong and Japan exhibiting medium trust (predicted to be low and high respectively) and Australia and South Korea exhibiting low trust (predicted to be high and medium respectively). Taiwan was the only country where the actual and predicted trust was the same, namely low trust. Given the fact that these predictors crossed national boundaries and institutional types, further research and policy should focus specifically on improving trust within these groups in order that they can be empowered to play a more central role in democratic vitality. PMID:27701439

Evaluating the response of biological assemblages as potential indicators for restoration measures in an intermittent Mediterranean river.

PubMed

Hughes, Samantha Jane; Santos, Jose; Ferreira, Teresa; Mendes, Ana

2010-08-01

Bioindicators are essential for detecting environmental degradation and for assessing the success of river restoration initiatives. River restoration projects require the identification of environmental and pressure gradients that affect the river system under study and the selection of suitable indicators to assess habitat quality before, during and after restoration. We assessed the response of benthic macroinvertebrates, fish, bird and macrophyte assemblages to environmental and pressure gradients from sites situated upstream and downstream of a cofferdam on the River Odelouca, an intermittent Mediterranean river in southwest Portugal. The Odelouca will be permanently dammed in 2010. Principal Component Analyses (PCA) of environmental and pressure variables revealed that most variance was explained by environmental factors that clearly separated sites upstream and downstream of the partially built cofferdam. The pressure gradient describing physical impacts to the banks and channel as a result of land use change was less distinct. Redundancy Analysis revealed significant levels of explained variance to species distribution patterns in relation to environmental and pressure variables for all 4 biological assemblages. Partial Redundancy analyses revealed high levels of redundancy for pH between groups and that the avifauna was best associated with pressures acting upon the system. Patterns in invertebrates and fish were associated with descriptors of habitat quality, although fish distribution patterns were affected by reduced connectivity. Procrustean and RELATE (Mantel test) analyses gave broadly similar results and supported these findings. We give suggestions on the suitability of key indicator groups such as benthic macroinvertebrates and endemic fish species to assess in stream habitat quality and appropriate restoration measures, such as the release of peak flow patterns that mimic intermittent Mediterranean systems to combat habitat fragmentation and reduced connectivity.

Evaluating the Response of Biological Assemblages as Potential Indicators for Restoration Measures in an Intermittent Mediterranean River

NASA Astrophysics Data System (ADS)

Hughes, Samantha Jane; Santos, Jose; Ferreira, Teresa; Mendes, Ana

2010-08-01

Bioindicators are essential for detecting environmental degradation and for assessing the success of river restoration initiatives. River restoration projects require the identification of environmental and pressure gradients that affect the river system under study and the selection of suitable indicators to assess habitat quality before, during and after restoration. We assessed the response of benthic macroinvertebrates, fish, bird and macrophyte assemblages to environmental and pressure gradients from sites situated upstream and downstream of a cofferdam on the River Odelouca, an intermittent Mediterranean river in southwest Portugal. The Odelouca will be permanently dammed in 2010. Principal Component Analyses (PCA) of environmental and pressure variables revealed that most variance was explained by environmental factors that clearly separated sites upstream and downstream of the partially built cofferdam. The pressure gradient describing physical impacts to the banks and channel as a result of land use change was less distinct. Redundancy Analysis revealed significant levels of explained variance to species distribution patterns in relation to environmental and pressure variables for all 4 biological assemblages. Partial Redundancy analyses revealed high levels of redundancy for pH between groups and that the avifauna was best associated with pressures acting upon the system. Patterns in invertebrates and fish were associated with descriptors of habitat quality, although fish distribution patterns were affected by reduced connectivity. Procrustean and RELATE (Mantel test) analyses gave broadly similar results and supported these findings. We give suggestions on the suitability of key indicator groups such as benthic macroinvertebrates and endemic fish species to assess in stream habitat quality and appropriate restoration measures, such as the release of peak flow patterns that mimic intermittent Mediterranean systems to combat habitat fragmentation and reduced connectivity.

The Role of Demand Response in Reducing Water-Related Power Plant Vulnerabilities

NASA Astrophysics Data System (ADS)

Macknick, J.; Brinkman, G.; Zhou, E.; O'Connell, M.; Newmark, R. L.; Miara, A.; Cohen, S. M.

2015-12-01

The electric sector depends on readily available water supplies for reliable and efficient operation. Elevated water temperatures or low water levels can trigger regulatory or plant-level decisions to curtail power generation, which can affect system cost and reliability. In the past decade, dozens of power plants in the U.S. have curtailed generation due to water temperatures and water shortages. Curtailments occur during the summer, when temperatures are highest and there is greatest demand for electricity. Climate change could alter the availability and temperature of water resources, exacerbating these issues. Constructing alternative cooling systems to address vulnerabilities can be capital intensive and can also affect power plant efficiencies. Demand response programs are being implemented by electric system planners and operators to reduce and shift electricity demands from peak usage periods to other times of the day. Demand response programs can also play a role in reducing water-related power sector vulnerabilities during summer months. Traditionally, production cost modeling and demand response analyses do not include water resources. In this effort, we integrate an electricity production cost modeling framework with water-related impacts on power plants in a test system to evaluate the impacts of demand response measures on power system costs and reliability. Specifically, we i) quantify the cost and reliability implications of incorporating water resources into production cost modeling, ii) evaluate the impacts of demand response measures on reducing system costs and vulnerabilities, and iii) consider sensitivity analyses with cooling systems to highlight a range of potential benefits of demand response measures. Impacts from climate change on power plant performance and water resources are discussed. Results provide key insights to policymakers and practitioners for reducing water-related power plant vulnerabilities via lower cost methods.

Establishing data-intensive healthcare: the case of Hospital Electronic Prescribing and Medicines Administration systems in Scotland.

PubMed

Cresswell, Kathrin; Smith, Pam; Swainson, Charles; Timoney, Angela; Sheikh, Aziz

2016-10-04

Creating learning health systems, characterised by the use and repeated reuse of demographic, process and clinical data to improve the safety, quality and efficiency of care, is a key aim in realising the potential benefits and efficiency savings associated with the implementation of health information technology. We sought to investigate stakeholder perspectives on and experiences of the implementation of hospital electronic prescribing and medicines administration (HEPMA) systems in Scotland and use these to inform political decisions on approaches to promoting the use and reuse of digitised prescribing and medication administration data in order to improve care processes and outcomes.Methods We identified and recruited key national stakeholders involved in implementing and/or using HEPMA data from generic and specialty systems. These included representatives from healthcare settings (i.e. doctors, pharmacists and nurses), managers of existing national databases, policy makers, healthcare analytics companies, system suppliers and patient representatives. We conducted multi-disciplinary focus group discussions, audio-recorded these, transcribed data verbatim and thematically analysed the transcripts with the help of NVivo10. In analysing the data, we drew on theoretical and previous empirical work on information infrastructures. We identified the following key themes: 1) micro-factors - usability of systems and motivating users to input data; 2) meso-factors - developing technical and organisational infrastructures to facilitate the aggregation of data; and 3) macro-factors - facilitating interoperability and data reuse at larger scales to ensure that data are effectively generated and used. This work is relevant not only to countries in the early stages of data strategy development but also to countries aiming to aggregate data at national levels. An overall shared vision of a learning health system at individual, organisational and national levels can help to catalyse such data-intensive transformational efforts.

How sulphate-reducing microorganisms cope with stress: Lessons from systems biology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, J.; He, Q.; Hemme, C.L.

2011-04-01

Sulphate-reducing microorganisms (SRMs) are a phylogenetically diverse group of anaerobes encompassing distinct physiologies with a broad ecological distribution. As SRMs have important roles in the biogeochemical cycling of carbon, nitrogen, sulphur and various metals, an understanding of how these organisms respond to environmental stresses is of fundamental and practical importance. In this Review, we highlight recent applications of systems biology tools in studying the stress responses of SRMs, particularly Desulfovibrio spp., at the cell, population, community and ecosystem levels. The syntrophic lifestyle of SRMs is also discussed, with a focus on system-level analyses of adaptive mechanisms. Such information is importantmore » for understanding the microbiology of the global sulphur cycle and for developing biotechnological applications of SRMs for environmental remediation, energy production, biocorrosion control, wastewater treatment and mineral recovery.« less

The Silicon Trypanosome: a test case of iterative model extension in systems biology

PubMed Central

Achcar, Fiona; Fadda, Abeer; Haanstra, Jurgen R.; Kerkhoven, Eduard J.; Kim, Dong-Hyun; Leroux, Alejandro E.; Papamarkou, Theodore; Rojas, Federico; Bakker, Barbara M.; Barrett, Michael P.; Clayton, Christine; Girolami, Mark; Luise Krauth-Siegel, R.; Matthews, Keith R.; Breitling, Rainer

2016-01-01

The African trypanosome, Trypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome (SilicoTryp) is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology. PMID:24797926

FEATURES, EVENTS, AND PROCESSES: SYSTEM-LEVEL AND CRITICALITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

D.L. McGregor

The primary purpose of this Analysis/Model Report (AMR) is to identify and document the screening analyses for the features, events, and processes (FEPs) that do not easily fit into the existing Process Model Report (PMR) structure. These FEPs include the 3 1 FEPs designated as System-Level Primary FEPs and the 22 FEPs designated as Criticality Primary FEPs. A list of these FEPs is provided in Section 1.1. This AMR (AN-WIS-MD-000019) documents the Screening Decision and Regulatory Basis, Screening Argument, and Total System Performance Assessment (TSPA) Disposition for each of the subject Primary FEPs. This AMR provides screening information and decisionsmore » for the TSPA-SR report and provides the same information for incorporation into a project-specific FEPs database. This AMR may also assist reviewers during the licensing-review process.« less

The Role of Thaumarchaeota in N2O generation in an unconfined basalt-sandstone aquifer system, Western Victoria (Australia)

NASA Astrophysics Data System (ADS)

Moreau, J. W.; Hepburn, E.

2015-12-01

The mechanisms by which nitrous oxide is produced and transformed in groundwater are poorly understood. Here we used GC-MS and nitrogen and oxygen isotope analyses to quantify nitrate, ammonia and nitrous oxide levels in nitrate-contaminated aquifers in the Newer Volcanics province of Western Victoria. Quantitative polymerase chain reaction (Q-PCR), and phylogenetic analyses of functional nitrogen-cycling and 16S rRNA genes, of whole community microbial DNA from groundwater samples obtained from different depths within different aquifers with low-flow pumping revealed nitrate, ammonia and nitrous oxide levels of up to ~40 mg/L, up to ~0.85 mg/L, and up to ~770 nM, respectively in several groundwater samples. Delta 15N and delta 18O values ranged from -2.68‰ to 68.19‰ and -3.37‰ to 26.83‰, respectively. Nitrate and nitrous oxide concentrations decreased with depth in the unconfined aquifer, while TOC generally increased. Higher ammonia levels were observed in more heavily ferruginized sandstones. Increaased nitrate and nitrous oxide levels were found within the principal basaltic aquifers. Q-PCR results showed variable concentrations of nir, nar, nos and amo genes associated with different redox transformations along the nitrification and denitrification pathways, indicating potential nitrous oxide formation via both pathways within different depths in the aquifer. 16S rRNA gene analyses implicated an important role for the Thaumarchaeota in groundwater nitrogen cycling.

Design of isolated buildings with S-FBI system subjected to near-fault earthquakes using NSGA-II algorithm

NASA Astrophysics Data System (ADS)

Ozbulut, O. E.; Silwal, B.

2014-04-01

This study investigates the optimum design parameters of a superelastic friction base isolator (S-FBI) system through a multi-objective genetic algorithm and performance-based evaluation approach. The S-FBI system consists of a flat steel- PTFE sliding bearing and a superelastic NiTi shape memory alloy (SMA) device. Sliding bearing limits the transfer of shear across the isolation interface and provides damping from sliding friction. SMA device provides restoring force capability to the isolation system together with additional damping characteristics. A three-story building is modeled with S-FBI isolation system. Multiple-objective numerical optimization that simultaneously minimizes isolation-level displacements and superstructure response is carried out with a genetic algorithm (GA) in order to optimize S-FBI system. Nonlinear time history analyses of the building with S-FBI system are performed. A set of 20 near-field ground motion records are used in numerical simulations. Results show that S-FBI system successfully control response of the buildings against near-fault earthquakes without sacrificing in isolation efficacy and producing large isolation-level deformations.

NEXT Ion Propulsion System Development Status and Capabilities

NASA Technical Reports Server (NTRS)

Patterson, Michael J.; Benson, Scott W.

2008-01-01

NASA s Evolutionary Xenon Thruster (NEXT) project is developing next generation ion propulsion technologies to provide future NASA science missions with enhanced mission performance benefit at a low total development cost. The objective of the NEXT project is to advance next generation ion propulsion technology by producing engineering model system components, validating these through qualification-level and integrated system testing, and ensuring preparedness for transitioning to flight system development. As NASA s Evolutionary Xenon Thruster technology program completes advanced development activities, it is advantageous to review the existing technology capabilities of the system under development. This paper describes the NEXT ion propulsion system development status, characteristics and performance. A review of mission analyses results conducted to date using the NEXT system is also provided.

Analysis of Affecting Factors and Construction of Index System of Rural Domestic Pollution in Guangxi Province

NASA Astrophysics Data System (ADS)

Chen, Hong; Duan, Chunyi

2018-01-01

This paper systematically analysed the influential factors of rural domestic pollution in Guangxi and the current situation and evaluation index of rural domestic pollution, constructed moisture contents indexes system, which included two kinds of indicators in three levels, in a total of 19 indicators of rural domestic pollution. According to the moisture contents indexes system, a combination of quantitative and qualitative methods were adopted to make regionalization of rural domestic pollution in Guangxi more reasonable and provided scientific support for the prevention and control of rural domestic pollution in Guangxi Province.

Politics of innovation in multi-level water governance systems

NASA Astrophysics Data System (ADS)

Daniell, Katherine A.; Coombes, Peter J.; White, Ian

2014-11-01

Innovations are being proposed in many countries in order to support change towards more sustainable and water secure futures. However, the extent to which they can be implemented is subject to complex politics and powerful coalitions across multi-level governance systems and scales of interest. Exactly how innovation uptake can be best facilitated or blocked in these complex systems is thus a matter of important practical and research interest in water cycle management. From intervention research studies in Australia, China and Bulgaria, this paper seeks to describe and analyse the behind-the-scenes struggles and coalition-building that occurs between water utility providers, private companies, experts, communities and all levels of government in an effort to support or block specific innovations. The research findings suggest that in order to ensure successful passage of the proposed innovations, champions for it are required from at least two administrative levels, including one with innovation implementation capacity, as part of a larger supportive coalition. Higher governance levels can play an important enabling role in facilitating the passage of certain types of innovations that may be in competition with currently entrenched systems of water management. Due to a range of natural biases, experts on certain innovations and disciplines may form part of supporting or blocking coalitions but their evaluations of worth for water system sustainability and security are likely to be subject to competing claims based on different values and expertise, so may not necessarily be of use in resolving questions of "best courses of action". This remains a political values-based decision to be negotiated through the receiving multi-level water governance system.

The interaction between self-regulation and motivation prospectively predicting problem behavior in adolescence.

PubMed

Rhodes, Jessica D; Colder, Craig R; Trucco, Elisa M; Speidel, Carolyn; Hawk, Larry W; Lengua, Liliana J; Das Eiden, Rina; Wieczorek, William

2013-01-01

A large literature suggests associations between self-regulation and motivation and adolescent problem behavior; however, this research has mostly pitted these constructs against one another or tested them in isolation. Following recent neural-systems based theories (e.g., Ernst & Fudge, 2009 ), the present study investigated the interactions between self-regulation and approach and avoidance motivation prospectively predicting delinquency and depressive symptoms in early adolescence. The community sample included 387 adolescents aged 11 to 13 years old (55% female; 17% minority). Laboratory tasks were used to assess self-regulation and approach and avoidance motivation, and adolescent self-reports were used to measure depressive symptoms and delinquency. Analyses suggested that low levels of approach motivation were associated with high levels of depressive symptoms, but only at high levels of self-regulation (p = .01). High levels of approach were associated with high levels of rule breaking, but only at low levels of self-regulation (p < .05). These findings support contemporary neural-based systems theories that posit integration of motivational and self-regulatory individual differences via moderational models to understand adolescent problem behavior.

The Interaction Between Self-Regulation and Motivation Prospectively Predicting Problem Behavior in Adolescence

PubMed Central

Rhodes, Jessica D.; Colder, Craig R.; Trucco, Elisa M.; Speidel, Carolyn; Hawk, Larry W.; Lengua, Liliana J.; Eiden, Rina Das; Wiezcorek, William

2013-01-01

Objective A large literature suggests associations between self-regulation and motivation and adolescent problem behavior, however this research has mostly pitted these constructs against one another or tested them in isolation. Following recent neural-systems based theories (e.g., Ernst & Fudge, 2009), the present study investigated the interactions between self-regulation and approach and avoidance motivation prospectively predicting delinquency and depressive symptoms in early adolescence. Method The community sample included 387 adolescents aged 11–13 years old (55% female; 17% minority). Laboratory tasks were used to assess self-regulation and approach and avoidance motivation, and adolescent self-reports were used to measure depressive symptoms and delinquency. Results Analyses suggested that low levels of approach motivation were associated with high levels of depressive symptoms, but only at high levels of self-regulation (p = .01). High levels of approach were associated with high levels of rule breaking, but only at low levels of self-regulation (p < .05). Conclusions These findings support contemporary neural-based systems theories that posit integration of motivational and self-regulatory individual differences via moderational models to understand adolescent problem behavior. PMID:23477426

Corporate governance and proactive environmental management in Novo Hamburgo and neighbouring cities, Brazil.

PubMed

Naime, R; Spilki, F R; Nascimento, C A

2015-05-01

This study compiled data on environmental auditing and voluntary certification of environment-friendly businesses of the Commercial and Industrial Association of Novo Hamburgo, Campo Bom and Estância Velha and analysed them according to classical environmental management principles: sustainable development and corporate governance. It assessed the level of application of the concepts of corporate governance to everyday business in companies and organisations and estimated how the interconnection and vertical permeability of these concepts might help to make bureaucratic environmental management systemic, proactive and evaluative, changes that may add great value to the operations evaluated. Results showed that, when analysing only audited items not directly defined in legislation, no significant changes were identified. The inclusion of more advanced indices may promote the transition from bureaucratic management, which meets regulated environmental standards only satisfactorily, into proactive and systemic environmental management, which adds value to companies and helps to perpetuate them. Audited and analysed data did not reveal actions that depend on the internal redistribution of power and the interconnection or verticality of attitudes that may materialize concepts of corporate governance.

78 FR 15746 - Compendium of Analyses To Investigate Select Level 1 Probabilistic Risk Assessment End-State...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-12

... NUCLEAR REGULATORY COMMISSION [NRC-2013-0047] Compendium of Analyses To Investigate Select Level 1...) has issued for public comment a document entitled: Compendium of Analyses to Investigate Select Level... begin the search, select ``ADAMS Public Documents'' and then select ``Begin Web- based ADAMS Search...

Copernicus stratospheric ozone service, 2009-2012: validation, system intercomparison and roles of input data sets

NASA Astrophysics Data System (ADS)

Lefever, K.; van der A, R.; Baier, F.; Christophe, Y.; Errera, Q.; Eskes, H.; Flemming, J.; Inness, A.; Jones, L.; Lambert, J.-C.; Langerock, B.; Schultz, M. G.; Stein, O.; Wagner, A.; Chabrillat, S.

2015-03-01

This paper evaluates and discusses the quality of the stratospheric ozone analyses delivered in near real time by the MACC (Monitoring Atmospheric Composition and Climate) project during the 3-year period between September 2009 and September 2012. Ozone analyses produced by four different chemical data assimilation (CDA) systems are examined and compared: the Integrated Forecast System coupled to the Model for OZone And Related chemical Tracers (IFS-MOZART); the Belgian Assimilation System for Chemical ObsErvations (BASCOE); the Synoptic Analysis of Chemical Constituents by Advanced Data Assimilation (SACADA); and the Data Assimilation Model based on Transport Model version 3 (TM3DAM). The assimilated satellite ozone retrievals differed for each system; SACADA and TM3DAM assimilated only total ozone observations, BASCOE assimilated profiles for ozone and some related species, while IFS-MOZART assimilated both types of ozone observations. All analyses deliver total column values that agree well with ground-based observations (biases < 5%) and have a realistic seasonal cycle, except for BASCOE analyses, which underestimate total ozone in the tropics all year long by 7 to 10%, and SACADA analyses, which overestimate total ozone in polar night regions by up to 30%. The validation of the vertical distribution is based on independent observations from ozonesondes and the ACE-FTS (Atmospheric Chemistry Experiment - Fourier Transform Spectrometer) satellite instrument. It cannot be performed with TM3DAM, which is designed only to deliver analyses of total ozone columns. Vertically alternating positive and negative biases are found in the IFS-MOZART analyses as well as an overestimation of 30 to 60% in the polar lower stratosphere during polar ozone depletion events. SACADA underestimates lower stratospheric ozone by up to 50% during these events above the South Pole and overestimates it by approximately the same amount in the tropics. The three-dimensional (3-D) analyses delivered by BASCOE are found to have the best quality among the three systems resolving the vertical dimension, with biases not exceeding 10% all year long, at all stratospheric levels and in all latitude bands, except in the tropical lowermost stratosphere. The northern spring 2011 period is studied in more detail to evaluate the ability of the analyses to represent the exceptional ozone depletion event, which happened above the Arctic in March 2011. Offline sensitivity tests are performed during this month and indicate that the differences between the forward models or the assimilation algorithms are much less important than the characteristics of the assimilated data sets. They also show that IFS-MOZART is able to deliver realistic analyses of ozone both in the troposphere and in the stratosphere, but this requires the assimilation of observations from nadir-looking instruments as well as the assimilation of profiles, which are well resolved vertically and extend into the lowermost stratosphere.

Navigation Strategies for Primitive Solar System Body Rendezvous and Proximity Operations

NASA Technical Reports Server (NTRS)

Getzandanner, Kenneth M.

2011-01-01

A wealth of scientific knowledge regarding the composition and evolution of the solar system can be gained through reconnaissance missions to primitive solar system bodies. This paper presents analysis of a baseline navigation strategy designed to address the unique challenges of primitive body navigation. Linear covariance and Monte Carlo error analysis was performed on a baseline navigation strategy using simulated data from a· design reference mission (DRM). The objective of the DRM is to approach, rendezvous, and maintain a stable orbit about the near-Earth asteroid 4660 Nereus. The outlined navigation strategy and resulting analyses, however, are not necessarily limited to this specific target asteroid as they may he applicable to a diverse range of mission scenarios. The baseline navigation strategy included simulated data from Deep Space Network (DSN) radiometric tracking and optical image processing (OpNav). Results from the linear covariance and Monte Carlo analyses suggest the DRM navigation strategy is sufficient to approach and perform proximity operations in the vicinity of the target asteroid with meter-level accuracy.

Quantitative Enzymatic and Immunologic Histophotometry of Diseased Human Kid-Ney Tissues Using Tv-Camera and Computer Assisted Image Processing Systems.

NASA Astrophysics Data System (ADS)

Heinert, G.; Mondorf, W.

1982-11-01

High speed image processing was used to analyse morphologic and metabolic characteristics of clinically relevant kidney tissue alterations.Qualitative computer-assisted histophotometry was performed to measure alterations in levels of the enzymes alkaline phosphatase (Ap),alanine aminopeptidase (AAP),g-glutamyltranspepti-dase (GGTP) and A-glucuronidase (B-G1) and AAP and GGTP immunologically determined in prepared renal and cancer tissue sections. A "Mioro-Videomat 2" image analysis system with a "Tessovar" macroscope,a computer-assisted "Axiomat" photomicroscope and an "Interactive Image Analysis System (IBAS)" were employed for analysing changes in enzyme activities determined by changes in absorbance or transmission.Diseased kidney as well as renal neoplastic tissues could be distinguished by significantly (wilcoxon test,p<0,05) decreased enzyme concentrations as compared to those found in normal human kidney tissues.This image analysis techniques might be of potential use in diagnostic and prognostic evaluation of renal cancer and diseased kidney tissues.

Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels.

PubMed

Poulsen, Ebbe Toftgaard; Pedersen, Kata Wolff; Marzeda, Anna Maria; Enghild, Jan J

2017-02-14

The pentraxin serum amyloid P component (SAP) is secreted by the liver and found in plasma at a concentration of approximately 30 mg/L. SAP is a 25 kDa homopentamer known to bind both protein and nonprotein ligands, all in a calcium-dependent manner. The function of SAP is unclear but likely involves the humoral innate immune system spanning the complement system, inflammation, and coagulation. Also, SAP is known to bind to the generic structure of amyloid deposits and possibly to protect them against proteolysis. In this study, we have characterized the SAP interactome in human plasma containing the physiological Ca 2+ concentration using SAP affinity pull-down and co-immunoprecipitation experiments followed by mass spectrometry analyses. The analyses resulted in the identification of 33 proteins, of which 24 were direct or indirect interaction partners not previously reported. The SAP interactome can be divided into categories that include apolipoproteins, the complement system, coagulation, and proteolytic regulation.

Performance and capacity analysis of Poisson photon-counting based Iter-PIC OCDMA systems.

PubMed

Li, Lingbin; Zhou, Xiaolin; Zhang, Rong; Zhang, Dingchen; Hanzo, Lajos

2013-11-04

In this paper, an iterative parallel interference cancellation (Iter-PIC) technique is developed for optical code-division multiple-access (OCDMA) systems relying on shot-noise limited Poisson photon-counting reception. The novel semi-analytical tool of extrinsic information transfer (EXIT) charts is used for analysing both the bit error rate (BER) performance as well as the channel capacity of these systems and the results are verified by Monte Carlo simulations. The proposed Iter-PIC OCDMA system is capable of achieving two orders of magnitude BER improvements and a 0.1 nats of capacity improvement over the conventional chip-level OCDMA systems at a coding rate of 1/10.

Parentage assignment and extra-group paternity in a cooperative breeder: the Seychelles warbler (Acrocephalus sechellensis).

PubMed

Richardson, D S; Jury, F L; Blaakmeer, K; Komdeur, J; Burke, T

2001-09-01

We describe the development and initial application of a semiautomated parentage testing system in the Seychelles warbler (Acrocephalus sechellensis). This system used fluorescently labelled primers for 14 polymorphic microsatellite loci in two multiplex loading groups to genotype efficiently over 96% of the warbler population on Cousin island. When used in conjunction with the program CERVUS, this system provided sufficient power to assign maternity and paternity within the Seychelles warbler, despite the complications associated with its cooperative breeding system and a relatively low level of genetic variation. Parentage analyses showed that subordinate 'helper' females as well as the dominant 'primary' females laid eggs in communal nests, indicating that the Seychelles warbler has an intermediate level of female reproductive skew, in between the alternative extremes of helper-at-the-nest and joint nesting systems. Forty-four per cent of helpers bred successfully, accounting for 15% of all offspring. Forty per cent of young resulted from extra-group paternity.

Performance comparison between the high-speed Yokogawa spinning disc confocal system and single-point scanning confocal systems.

PubMed

Wang, E; Babbey, C M; Dunn, K W

2005-05-01

Fluorescence microscopy of the dynamics of living cells presents a special challenge to a microscope imaging system, simultaneously requiring both high spatial resolution and high temporal resolution, but with illumination levels low enough to prevent fluorophore damage and cytotoxicity. We have compared the high-speed Yokogawa CSU10 spinning disc confocal system with several conventional single-point scanning confocal (SPSC) microscopes, using the relationship between image signal-to-noise ratio and fluorophore photobleaching as an index of system efficiency. These studies demonstrate that the efficiency of the CSU10 consistently exceeds that of the SPSC systems. The high efficiency of the CSU10 means that quality images can be collected with much lower levels of illumination; the CSU10 was capable of achieving the maximum signal-to-noise of an SPSC system at illumination levels that incur only at 1/15th of the rate of the photobleaching of the SPSC system. Although some of the relative efficiency of the CSU10 system may be attributed to the use of a CCD rather than a photomultiplier detector system, our analyses indicate that high-speed imaging with the SPSC system is limited by fluorescence saturation at the high levels of illumination frequently needed to collect images at high frame rates. The high speed, high efficiency and freedom from fluorescence saturation combine to make the CSU10 effective for extended imaging of living cells at rates capable of capturing the three-dimensional motion of endosomes moving up to several micrometres per second.

The need to look at antibiotic resistance from a health systems perspective

PubMed Central

Vlad, Ioana

2014-01-01

Current use, misuse, and overuse of antibiotics raise dangers and ethical dilemmas that cannot be solved in isolation, exclusively within a health system building block or even within the health sector only. There is a need to tackle antibiotic resistance emergence and containment on levels ranging from individuals, households, and the communities, to health care facilities, the entire health sector, and finally to national and global levels. We analyse emergence of antibiotic resistance based on interdependencies between health systems resources. We further go beyond the health system building blocks, to look at determinants of antibiotic resistance referring to wider global dynamics. Multi-level governance is the key for successful action in containment strategies. This will involve, in a comprehensive way, patients, health facilities where they receive care, health systems to which these facilities pertain, and the wider national context as well as the global community that influences the functioning of these health systems. In order to be effective and sustainable in both high and low-resource settings, implementation of containment interventions at all these levels needs to be managed based on existing theories and models of change. Although ministries of health and the global community must provide vision and support, it is important to keep in mind that containment interventions for antibiotic resistance will target individuals, consumers as well as providers. PMID:24673267

Analysing reduced tillage practices within a bio-economic modelling framework.

PubMed

Townsend, Toby J; Ramsden, Stephen J; Wilson, Paul

2016-07-01

Sustainable intensification of agricultural production systems will require changes in farm practice. Within arable cropping systems, reducing the intensity of tillage practices (e.g. reduced tillage) potentially offers one such sustainable intensification approach. Previous researchers have tended to examine the impact of reduced tillage on specific factors such as yield or weed burden, whilst, by definition, sustainable intensification necessitates a system-based analysis approach. Drawing upon a bio-economic optimisation model, 'MEETA', we quantify trade-off implications between potential yield reductions, reduced cultivation costs and increased crop protection costs. We extend the MEETA model to quantify farm-level net margin, in addition to quantifying farm-level gross margin, net energy, and greenhouse gas emissions. For the lowest intensity tillage system, zero tillage, results demonstrate financial benefits over a conventional tillage system even when the zero tillage system includes yield penalties of 0-14.2% (across all crops). Average yield reductions from zero tillage literature range from 0 to 8.5%, demonstrating that reduced tillage offers a realistic and attainable sustainable intensification intervention, given the financial and environmental benefits, albeit that yield reductions will require more land to compensate for loss of calories produced, negating environmental benefits observed at farm-level. However, increasing uptake of reduced tillage from current levels will probably require policy intervention; an extension of the recent changes to the CAP ('Greening') provides an opportunity to do this.

Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD

PubMed Central

Zhao, Peng; Yang, Liping; Li, Jiansheng; Li, Ya; Tian, Yange; Li, Suyun

2016-01-01

Bufei Jianpi formula (BJF) has long been used as a therapeutic agent in the treatment of COPD. Systems pharmacology identified 145 active compounds and 175 potential targets of BJF in a previous study. Additionally, BJF was previously shown to effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. However, the system-level mechanism of BJF for the treatment of COPD is still unclear. The aim of this study was to gain insight into its system-level mechanisms by integrating transcriptomics, proteomics, and metabolomics together with systems pharmacology datasets. Using molecular function, pathway, and network analyses, the genes and proteins regulated in COPD rats and BJF-treated rats could be mainly attributed to oxidoreductase activity, antioxidant activity, focal adhesion, tight junction, or adherens junction. Furthermore, a comprehensive analysis of systems pharmacology, transcript, protein, and metabolite datasets is performed. The results showed that a number of genes, proteins, metabolites regulated in BJF-treated rats and potential target proteins of BJF were involved in lipid metabolism, cell junction, oxidative stress, and inflammatory response, which might be the system-level therapeutic mechanism of BJF treatment. PMID:27042044

Modelling the risk of mortality of Corbicula fluminea (Müller, 1774) (Bivalvia: Corbiculidae) exposed to different turbidity conditions.

PubMed

Avelar, W E P; Neves, F F; Lavrador, M A S

2014-05-01

The provision of sediment in rivers, due to erosion processes that occur in the environment, consists of a major source of pollution and alteration of the physicochemical conditions of water resources. In addition, the increase in water turbidity may cause siltation, dramatically impacting aquatic communities. Specifically considering the bivalve Corbicula fluminea (Müller, 1774), the aim of this study was to analyse the effect of exposure to different turbidity conditions of sediments, as a risk factor for the animals. For this purpose, a docking device was designed to ensure water circulation in a closed system and to maintain the desired levels of turbidity. Although C. fluminea can generally tolerate environmental changes in aquatic systems, an intolerance to high turbidity levels was experimentally observed, expressed by the mortality rate of the animals when exposed to conditions above 150 nephelometric turbidity units (NTU). This value was similar to the one recorded at study sites in the rivers Pardo (Serrana-SP-Brazil) and Mogi Guaçu (Porto Ferreira-SP-Brazil) during the rainy season. Using a logistic regression model, the experimental results were analysed and the observed mortality rates indicate that the exposure of the animals to turbidity levels above 150 nephelometric turbidity units (NTU), for periods longer than 120 hours, may be considered a probable cause of mortality for the species.

A molecular analysis of African lion (Panthera leo) mating structure and extra-group paternity in Etosha National Park.

PubMed

Lyke, M M; Dubach, J; Briggs, M B

2013-05-01

The recent incorporation of molecular methods into analyses of social and mating systems has provided evidence that mating patterns often differ from those predicted by group social organization. Based on field studies and paternity analyses at a limited number of sites, African lions are predicted to exhibit a strict within-pride mating system. Extra-group paternity has not been previously reported in African lions; however, observations of extra-group associations among lions inhabiting Etosha National Park in Namibia suggest deviation from the predicted within-pride mating pattern. We analysed variation in 14 microsatellite loci in a population of 164 African lions in Etosha National Park. Genetic analysis was coupled with demographic and observational data to examine pride structure, relatedness and extra-group paternity (EGP). EGP was found to occur in 57% of prides where paternity was analysed (n = 7), and the overall rate of EGP in this population was 41% (n = 34). Group sex ratio had a significant effect on the occurrence of EGP (P < 0.05), indicating that variation in pride-level social structure may explain intergroup variation in EGP. Prides with a lower male-to-female ratio were significantly more likely to experience EGP in this population. The results of this study challenge the current models of African lion mating systems and provide evidence that social structure may not reflect breeding structure in some social mammals. © 2013 Blackwell Publishing Ltd.

Environmental Testing Philosophy for a Sandia National Laboratories' Small Satellite Project - A Retrospective

DOE Office of Scientific and Technical Information (OSTI.GOV)

CAP,JEROME S.

2000-08-24

Sandia has recently completed the flight certification test series for the Multi-Spectral Thermal Imaging satellite (MTI), which is a small satellite for which Sandia was the system integrator. A paper was presented at the 16th Aerospace Testing Seminar discussing plans for performing the structural dynamics certification program for that satellite. The testing philosophy was originally based on a combination of system level vibroacoustic tests and component level shock and vibration tests. However, the plans evolved to include computational analyses using both Finite Element Analysis and Statistical Energy Analysis techniques. This paper outlines the final certification process and discuss lessons learnedmore » including both things that went well and things that should/could have been done differently.« less

[The socio-hygienic monitoring as an integral system for health risk assessment and risk management at the regional level].

PubMed

Kuzmin, S V; Gurvich, V B; Dikonskaya, O V; Malykh, O L; Yarushin, S V; Romanov, S V; Kornilkov, A S

2013-01-01

The information and analytical framework for the introduction of health risk assessment and risk management methodologies in the Sverdlovsk Region is the system of socio-hygienic monitoring. Techniques of risk management that take into account the choice of most cost-effective and efficient actions for improvement of the sanitary and epidemiologic situation at the level of the region, municipality, or a business entity of the Russian Federation, have been developed and proposed. To assess the efficiency of planning and activities for health risk management common method approaches and economic methods of "cost-effectiveness" and "cost-benefit" analyses provided in method recommendations and introduced in the Russian Federation are applied.

Two dimensions of trust in physicians in OECD-countries.

PubMed

Saarinen, Arttu Olavi; Räsänen, Pekka; Kouvo, Antti

2016-01-01

The purpose of this paper is to analyse citizens' trust in physicians in 22 OECD countries. The authors measure trust in physicians using items on generalised and particularised trust. Individual-level data are received from the ISSP Research Group (2011). The authors also utilise macro variables drawn from different data banks. Data were analysed using descriptive statistics and xtlogit regression models. The main micro-level hypothesis is that low self-reported health is strongly associated with lower trust in physicians. The second micro-level hypothesis is that frequent meetings with physicians result in higher trust. The third micro-level hypothesis assumes that males, and older and better educated respondents, express higher trust compared to others. The first macro-level hypothesis is that lower income inequality leads to higher trust in physicians. The second macro-level hypothesis is that greater physician density leads to higher trust in physicians. The authors found that the influence of individual and macro-level characteristics varies between trust types. Results indicate that both trust types are clearly associated with individual-level determinants. However, only general trust in physicians has weak associations with macro-level indicators (mainly physician density) and therefore on institutional cross-country differences. It seems that particularised trust in a physician's skills is more restricted to the individuals' health and their own experiences meeting doctors, whereas general trust likely reflects attitudes towards the prevalent profession in the country. The findings hold significance for healthcare systems research and for research concerning social trust generally.

Modes of Interaction between Individuals Dominate the Topologies of Real World Networks

PubMed Central

Lee, Insuk; Kim, Eiru; Marcotte, Edward M.

2015-01-01

We find that the topologies of real world networks, such as those formed within human societies, by the Internet, or among cellular proteins, are dominated by the mode of the interactions considered among the individuals. Specifically, a major dichotomy in previously studied networks arises from modeling networks in terms of pairwise versus group tasks. The former often intrinsically give rise to scale-free, disassortative, hierarchical networks, whereas the latter often give rise to single- or broad-scale, assortative, nonhierarchical networks. These dependencies explain contrasting observations among previous topological analyses of real world complex systems. We also observe this trend in systems with natural hierarchies, in which alternate representations of the same networks, but which capture different levels of the hierarchy, manifest these signature topological differences. For example, in both the Internet and cellular proteomes, networks of lower-level system components (routers within domains or proteins within biological processes) are assortative and nonhierarchical, whereas networks of upper-level system components (internet domains or biological processes) are disassortative and hierarchical. Our results demonstrate that network topologies of complex systems must be interpreted in light of their hierarchical natures and interaction types. PMID:25793969

Fourier transform spectroscopy of MnH and MnD

NASA Astrophysics Data System (ADS)

Balfour, W. J.; Launila, O.; Klynning, L.

Two infrared band systems, centred near 846 nm and 1060 nm in both MnH and MnD have been rotationally analysed and shown to have a common lower state. The electronic transitions lie within the quintet manifold and are here designated c 5Σ-a 5Σ and b 5Πi-a 5Σ for the 846 and 1060 nm systems, respectively. In the 846 nm system in MnH all 10 main branches have been found in the 0-0 and 1-1 bands, while in MnD the data are complete only for 0-0. Satellite branches have been identified in the 1060 nm system and all spin and Λ-type doublings have been established. The number of assigned 0-0 branches in the 1060 nm system is 35 for MnH and 37 for MnD. Molecular constants have been determined for all three states involved. Λ-doubling diagrams are presented for b 5Πi state with v = 1, 2 levels in MnH and with the v = 2 level in MnD. Local perturbations in c5Σ (v = 1) in MnH are suspected to originate from the v = 3 level of b 5Πi.

Small reactor power systems for manned planetary surface bases

NASA Technical Reports Server (NTRS)

Bloomfield, Harvey S.

1987-01-01

A preliminary feasibility study of the potential application of small nuclear reactor space power systems to manned planetary surface base missions was conducted. The purpose of the study was to identify and assess the technology, performance, and safety issues associated with integration of reactor power systems with an evolutionary manned planetary surface exploration scenario. The requirements and characteristics of a variety of human-rated modular reactor power system configurations selected for a range of power levels from 25 kWe to hundreds of kilowatts is described. Trade-off analyses for reactor power systems utilizing both man-made and indigenous shielding materials are provided to examine performance, installation and operational safety feasibility issues. The results of this study have confirmed the preliminary feasibility of a wide variety of small reactor power plant configurations for growth oriented manned planetary surface exploration missions. The capability for power level growth with increasing manned presence, while maintaining safe radiation levels, was favorably assessed for nominal 25 to 100 kWe modular configurations. No feasibility limitations or technical barriers were identified and the use of both distance and indigenous planetary soil material for human rated radiation shielding were shown to be viable and attractive options.

Wind turbine generator interaction with conventional diesel generators on Block Island, Rhode Island. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Wilreker, V. F.; Stiller, P. H.; Scott, G. W.; Kruse, V. J.; Smith, R. F.

1984-01-01

Primary results are summarized for a three-part study involving the effects of connecting a MOD-OA wind turbine generator to an isolated diesel power system. The MOD-OA installation considered was the third of four experimental nominal 200 kW wind turbines connected to various utilities under the Federal Wind Energy Program and was characterized by the highest wind energy penetration levels of four sites. The study analyses address: fuel displacement, dynamic interaction, and three modes of reactive power control. These analyses all have as their basis the results of the data acquisition program conducted on Block Island, Rhode Island.

Social Skills Intervention Planning for Preschoolers: Using the SSiS-Rating Scales to Identify Target Behaviors Valued by Parents and Teachers

ERIC Educational Resources Information Center

Frey, Jennifer R.; Elliott, Stephen N.; Kaiser, Ann P.

2014-01-01

Teachers' and parents' importance ratings of social behaviors for 95 preschoolers were examined using the "Social Skills Improvement System-Rating Scales" (Gresham & Elliott, 2008). Multivariate analyses were used to examine parents' and teachers' importance ratings at the item and subscale levels. Overall,…

"Tracing" Europeanisation: School Leavers' and Graduates' Information Systems as an Example

ERIC Educational Resources Information Center

Hordósy, Rita

2016-01-01

This paper analyses the extent to which the process of Europeanisation can be observed within a specific policy area: that of school leaving and graduation. The paper investigates what is known about school leavers and graduates at the national and the European levels on the one hand, and how the data collections portray Europe and European policy…

Accuracy of Course Placement Validity Statistics under Various Soft Truncation Conditions. ACT Research Report Series 99-2.

ERIC Educational Resources Information Center

Schiel, Jeff L.; King, Jason E.

Analyses of data from operational course placement systems are subject to the effects of truncation; students with low placement test scores may enroll in a remedial course, rather than a standard-level course, and therefore will not have outcome data from the standard course. In "soft" truncation, some (but not all) students who score…

Metabolic profiling and enzyme analyses indicate a potential role of antioxidant systems in complementing glyphosate resistance in an Amaranthus palmeri biotype

USDA-ARS?s Scientific Manuscript database

Targeted metabolomic profiling and biochemical assays were employed to identify metabolite-level perturbations induced by glyphosate in susceptible (S) and resistant (R) biotypes of Amaranthus palmeri. Plants were treated with 0.4 kg ae ha-1 glyphosate and tissues were harvested at 8 and 72 hours af...

Accreditation of Prior Experiential Learning as a Catalyst for Lifelong Learning: Analysis and Proposals Based on French Experiments

ERIC Educational Resources Information Center

Sanseau, Pierre-Yves; Ansart, Sandrine

2013-01-01

In this paper, the researchers analyse how lifelong learning can be enriched and develop a different perspective based on the experiment involving the accreditation of prior experiential learning (APEL) conducted in France at the university level. The French system for the accreditation of prior experiential learning, called Validation des Acquis…

SPAR thermal analysis processors reference manual, system level 16. Volume 1: Program executive. Volume 2: Theory. Volume 3: Demonstration problems. Volume 4: Experimental thermal element capability. Volume 5: Programmer reference

NASA Technical Reports Server (NTRS)

Marlowe, M. B.; Moore, R. A.; Whetstone, W. D.

1979-01-01

User instructions are given for performing linear and nonlinear steady state and transient thermal analyses with SPAR thermal analysis processors TGEO, SSTA, and TRTA. It is assumed that the user is familiar with basic SPAR operations and basic heat transfer theory.

The impact of fire on the Late Paleozoic Earth system

PubMed Central

Glasspool, Ian J.; Scott, Andrew C.; Waltham, David; Pronina, Natalia; Shao, Longyi

2015-01-01

Analyses of bulk petrographic data indicate that during the Late Paleozoic wildfires were more prevalent than at present. We propose that the development of fire systems through this interval was controlled predominantly by the elevated atmospheric oxygen concentration (p(O2)) that mass balance models predict prevailed. At higher levels of p(O2), increased fire activity would have rendered vegetation with high-moisture contents more susceptible to ignition and would have facilitated continued combustion. We argue that coal petrographic data indicate that p(O2) rather than global temperatures or climate, resulted in the increased levels of wildfire activity observed during the Late Paleozoic and can, therefore, be used to predict it. These findings are based upon analyses of charcoal volumes in multiple coals distributed across the globe and deposited during this time period, and that were then compared with similarly diverse modern peats and Cenozoic lignites and coals. Herein, we examine the environmental and ecological factors that would have impacted fire activity and we conclude that of these factors p(O2) played the largest role in promoting fires in Late Paleozoic peat-forming environments and, by inference, ecosystems generally, when compared with their prevalence in the modern world. PMID:26442069

The impact of fire on the Late Paleozoic Earth system.

PubMed

Glasspool, Ian J; Scott, Andrew C; Waltham, David; Pronina, Natalia; Shao, Longyi

2015-01-01

Analyses of bulk petrographic data indicate that during the Late Paleozoic wildfires were more prevalent than at present. We propose that the development of fire systems through this interval was controlled predominantly by the elevated atmospheric oxygen concentration (p(O2)) that mass balance models predict prevailed. At higher levels of p(O2), increased fire activity would have rendered vegetation with high-moisture contents more susceptible to ignition and would have facilitated continued combustion. We argue that coal petrographic data indicate that p(O2) rather than global temperatures or climate, resulted in the increased levels of wildfire activity observed during the Late Paleozoic and can, therefore, be used to predict it. These findings are based upon analyses of charcoal volumes in multiple coals distributed across the globe and deposited during this time period, and that were then compared with similarly diverse modern peats and Cenozoic lignites and coals. Herein, we examine the environmental and ecological factors that would have impacted fire activity and we conclude that of these factors p(O2) played the largest role in promoting fires in Late Paleozoic peat-forming environments and, by inference, ecosystems generally, when compared with their prevalence in the modern world.

DKIST enclosure modeling and verification during factory assembly and testing

NASA Astrophysics Data System (ADS)

Larrakoetxea, Ibon; McBride, William; Marshall, Heather K.; Murga, Gaizka

2014-08-01

The Daniel K. Inouye Solar Telescope (DKIST, formerly the Advanced Technology Solar Telescope, ATST) is unique as, apart from protecting the telescope and its instrumentation from the weather, it holds the entrance aperture stop and is required to position it with millimeter-level accuracy. The compliance of the Enclosure design with the requirements, as of Final Design Review in January 2012, was supported by mathematical models and other analyses which included structural and mechanical analyses (FEA), control models, ventilation analysis (CFD), thermal models, reliability analysis, etc. During the Enclosure Factory Assembly and Testing the compliance with the requirements has been verified using the real hardware and the models created during the design phase have been revisited. The tests performed during shutter mechanism subsystem (crawler test stand) functional and endurance testing (completed summer 2013) and two comprehensive system-level factory acceptance testing campaigns (FAT#1 in December 2013 and FAT#2 in March 2014) included functional and performance tests on all mechanisms, off-normal mode tests, mechanism wobble tests, creation of the Enclosure pointing map, control system tests, and vibration tests. The comparison of the assumptions used during the design phase with the properties measured during the test campaign provides an interesting reference for future projects.

Implementing Evidence-Based Practice in Community Mental Health Agencies: A Multiple Stakeholder Analysis

PubMed Central

Wells, Rebecca S.; Zagursky, Karen; Fettes, Danielle L.; Palinkas, Lawrence A.

2009-01-01

Objectives. We sought to identify factors believed to facilitate or hinder evidence-based practice (EBP) implementation in public mental health service systems as a step in developing theory to be tested in future studies. Methods. Focusing across levels of an entire large public sector mental health service system for youths, we engaged participants from 6 stakeholder groups: county officials, agency directors, program managers, clinical staff, administrative staff, and consumers. Results. Participants generated 105 unique statements identifying implementation barriers and facilitators. Participants rated each statement on importance and changeability (i.e., the degree to which each barrier or facilitator is considered changeable). Data analyses distilled statements into 14 factors or dimensions. Descriptive analyses suggest that perceptions of importance and changeability varied across stakeholder groups. Conclusions. Implementation of EBP is a complex process. Cross-system–level approaches are needed to bring divergent and convergent perspectives to light. Examples include agency and program directors facilitating EBP implementation by supporting staff, actively sharing information with policymakers and administrators about EBP effectiveness and fit with clients' needs and preferences, and helping clinicians to present and deliver EBPs and address consumer concerns. PMID:19762654

Measurement of Lombard-like response in the beluga whale

NASA Astrophysics Data System (ADS)

Scheifele, Peter M.

2004-05-01

Noise pollution has become recognized as a potential danger to marine mammals in general, and to the St. Lawrence beluga (Delphinapterus leucas) in particular. One method to determine whether noise is having an effect on an animals auditory ability is to observe a natural and repeatable response of the auditory and vocal systems to varying noise levels. This can be accomplished by observing changes in animal vocalizations in response to auditory feedback. A response such as this observed in humans and some animals is known as the Lombard vocal response, which represents a reaction of the auditory system directly manifested by changes in vocalization level. This response is known in humans, songbirds, and some primates. In this research a population of belugas in the St. Lawrence River Estuary was tested to determine whether a vocalization-as-a-function-of-noise phenomenon existed by using hidden Markhov classified vocalizations as targets for acoustical analyses. Correlation and regression analyses of signals and noise indicated that the phenomenon does exist and results of a human subjects experiment along with results from other animal species known to exhibit the response strongly implicate the Lombard vocal response in the St. Lawrence population of beluga.

Miniature Gas Chromatograph (GC): Penning Ionization Electron Spectroscopy (PIES) Instrument for the Trace Analyses of Extraterrestrial Environments

NASA Technical Reports Server (NTRS)

Kojiro, Daniel R.; Sheverev, Valery A.; Holland, Paul M.; Takeuchi, Norishige

2006-01-01

In situ exploration of the solar system to identify its early chemistry as preserved in icy bodies and to look for compelling evidence of astrobiology will require new technology for chemical analysis. Chemical measurements in space flight environments highlight the need for a high level of positive identification of chemical compounds, since re-measurement by alternative techniques for confirmation will not be feasible. It also may not be possible to anticipate all chemical species that are observed, and important species may be present only at trace levels where they can be masked by complex chemical backgrounds. Up to now, the only techniques providing independent sample identification of GC separated components across a wide range of chemical species have been Mass Spectrometry (MS) and Ion Mobility Spectrometry (IMS). We describe here the development of a versatile and robust miniature GC detector based on Penning Ionization Electron Spectroscopy (PIES), for use with miniature GC systems being developed for planetary missions. PIES identifies the sample molecule through spectra related to its ionization potential. The combination of miniature GC technology with the primary identification capabilities of PIES provides an analytical approach ideal for planetary analyses.

Animal Board Invited Review: Comparing conventional and organic livestock production systems on different aspects of sustainability.

PubMed

van Wagenberg, C P A; de Haas, Y; Hogeveen, H; van Krimpen, M M; Meuwissen, M P M; van Middelaar, C E; Rodenburg, T B

2017-10-01

To sustainably contribute to food security of a growing and richer world population, livestock production systems are challenged to increase production levels while reducing environmental impact, being economically viable, and socially responsible. Knowledge about the sustainability performance of current livestock production systems may help to formulate strategies for future systems. Our study provides a systematic overview of differences between conventional and organic livestock production systems on a broad range of sustainability aspects and animal species available in peer-reviewed literature. Systems were compared on economy, productivity, environmental impact, animal welfare and public health. The review was limited to dairy cattle, beef cattle, pigs, broilers and laying hens, and to Europe, North America and New Zealand. Results per indicators are presented as in the articles without performing additional calculations. Out of 4171 initial search hits, 179 articles were analysed. Studies varied widely in indicators, research design, sample size and location and context. Quite some studies used small samples. No study analysed all aspects of sustainability simultaneously. Conventional systems had lower labour requirements per unit product, lower income risk per animal, higher production per animal per time unit, higher reproduction numbers, lower feed conversion ratio, lower land use, generally lower acidification and eutrophication potential per unit product, equal or better udder health for cows and equal or lower microbiological contamination. Organic systems had higher income per animal or full time employee, lower impact on biodiversity, lower eutrophication and acidification potential per unit land, equal or lower likelihood of antibiotic resistance in bacteria and higher beneficial fatty acid levels in cow milk. For most sustainability aspects, sometimes conventional and sometimes organic systems performed better, except for productivity, which was consistently higher in conventional systems. For many aspects and animal species, more data are needed to conclude on a difference between organic and conventional livestock production systems.

Coastal system mapping: a new approach to formalising and conceptualising the connectivity of large-scale coastal systems

NASA Astrophysics Data System (ADS)

French, J.; Burningham, H.; Whitehouse, R.

2010-12-01

The concept of the coastal sediment cell has proved invaluable as a basis for estimating sediment budgets and as a framework for coastal management. However, whilst coastal sediment cells are readily identified on compartmentalised coastlines dominated by beach-grade material, the cell concept is less suited to handling broader linkages between estuarine, coastal and offshore systems, and for incorporating longer-range suspended sediment transport. We present a new approach to the conceptualisation of large-scale coastal geomorphic systems based on a hierarchical classification of component landforms and management interventions and mapping of the interactions between them. Coastal system mapping is founded on a classification that identifies high-level landform features, low-level landform elements and engineering interventions. Geomorphic features define the large-scale organisation of a system and include landforms that define gross coastal configuration (e.g. headland, bay) as well as fluvial, estuarine and offshore sub-systems that exchange sediment with and influence the open coast. Detailed system structure is mapped out with reference to a larger set of geomorphic elements (e.g. cliff, dune, beach ridge). Element-element interactions define cross-shore linkages (conceptualised as hinterland, backshore and foreshore zones) and alongshore system structure. Both structural and non-structural engineering interventions are also represented at this level. Element-level mapping is rationalised to represent alongshore variation using as few elements as possible. System linkages include both sediment transfer pathways and influences not associated with direct mass transfer (e.g. effect of a jetty at an inlet). A formal procedure for capturing and graphically representing coastal system structure has been developed around free concept mapping software, CmapTools (http://cmap.ihmc.us). Appended meta-data allow geographic coordinates, data, images and literature pertaining to specific locations to be embedded in system maps. Exported maps can be analysed separately to quantify abundance of system components and their scales of interaction. Our approach is demonstrated for different scales and geomorphic contexts in the UK, including Alnmouth Bay (NE England; 15km), Lowestoft to Felixstowe (E England; 73km) and Cardigan Bay (Wales; 267km). Aerial imagery provides the primary basis for identifying features and elements and likely modes of interaction. This interpretation is then checked against relevant research literature and site data. Coastal system mapping is a kind of knowledge formalisation that generalises disparate sources of information (‘plain data’) into usable knowledge. Consensus-derived system maps are highly effective as a catalyst for structured discussion of geomorphic system behaviour and its implications for coastal management. They also function as a repository for results from quantitative analyses and modelling.

Unconscious analyses of visual scenes based on feature conjunctions.

PubMed

Tachibana, Ryosuke; Noguchi, Yasuki

2015-06-01

To efficiently process a cluttered scene, the visual system analyzes statistical properties or regularities of visual elements embedded in the scene. It is controversial, however, whether those scene analyses could also work for stimuli unconsciously perceived. Here we show that our brain performs the unconscious scene analyses not only using a single featural cue (e.g., orientation) but also based on conjunctions of multiple visual features (e.g., combinations of color and orientation information). Subjects foveally viewed a stimulus array (duration: 50 ms) where 4 types of bars (red-horizontal, red-vertical, green-horizontal, and green-vertical) were intermixed. Although a conscious perception of those bars was inhibited by a subsequent mask stimulus, the brain correctly analyzed the information about color, orientation, and color-orientation conjunctions of those invisible bars. The information of those features was then used for the unconscious configuration analysis (statistical processing) of the central bars, which induced a perceptual bias and illusory feature binding in visible stimuli at peripheral locations. While statistical analyses and feature binding are normally 2 key functions of the visual system to construct coherent percepts of visual scenes, our results show that a high-level analysis combining those 2 functions is correctly performed by unconscious computations in the brain. (c) 2015 APA, all rights reserved).

A systems biology perspective on the role of WRKY transcription factors in drought responses in plants.

PubMed

Tripathi, Prateek; Rabara, Roel C; Rushton, Paul J

2014-02-01

Drought is one of the major challenges affecting crop productivity and yield. However, water stress responses are notoriously multigenic and quantitative with strong environmental effects on phenotypes. It is also clear that water stress often does not occur alone under field conditions but rather in conjunction with other abiotic stresses such as high temperature and high light intensities. A multidisciplinary approach with successful integration of a whole range of -omics technologies will not only define the system, but also provide new gene targets for both transgenic approaches and marker-assisted selection. Transcription factors are major players in water stress signaling and some constitute major hubs in the signaling webs. The main transcription factors in this network include MYB, bHLH, bZIP, ERF, NAC, and WRKY transcription factors. The role of WRKY transcription factors in abiotic stress signaling networks is just becoming apparent and systems biology approaches are starting to define their places in the signaling network. Using systems biology approaches, there are now many transcriptomic analyses and promoter analyses that concern WRKY transcription factors. In addition, reports on nuclear proteomics have identified WRKY proteins that are up-regulated at the protein level by water stress. Interactomics has started to identify different classes of WRKY-interacting proteins. What are often lacking are connections between metabolomics, WRKY transcription factors, promoters, biosynthetic pathways, fluxes and downstream responses. As more levels of the system are characterized, a more detailed understanding of the roles of WRKY transcription factors in drought responses in crops will be obtained.

Effect of packing method on the randomness of disc packings

NASA Astrophysics Data System (ADS)

Zhang, Z. P.; Yu, A. B.; Oakeshott, R. B. S.

1996-06-01

The randomness of disc packings, generated by random sequential adsorption (RSA), random packing under gravity (RPG) and Mason packing (MP) which gives a packing density close to that of the RSA packing, has been analysed, based on the Delaunay tessellation, and is evaluated at two levels, i.e. the randomness at individual subunit level which relates to the construction of a triangle from a given edge length distribution and the randomness at network level which relates to the connection between triangles from a given triangle frequency distribution. The Delaunay tessellation itself is also analysed and its almost perfect randomness at the two levels is demonstrated, which verifies the proposed approach and provides a random reference system for the present analysis. It is found that (i) the construction of a triangle subunit is not random for the RSA, MP and RPG packings, with the degree of randomness decreasing from the RSA to MP and then to RPG packing; (ii) the connection of triangular subunits in the network is almost perfectly random for the RSA packing, acceptable for the MP packing and not good for the RPG packing. Packing method is an important factor governing the randomness of disc packings.

Heterogeniety and Heterarchy: How far can network analyses in Earth and space sciences?

NASA Astrophysics Data System (ADS)

Prabhu, A.; Fox, P. A.; Eleish, A.; Li, C.; Pan, F.; Zhong, H.

2017-12-01

The vast majority of explorations of Earth systems are limited in their ability to effectively explore the most important (often most difficult) problems because they are forced to interconnect at the data-element, or syntactic, level rather than at a higher scientific, or conceptual/ semantic, level. Recent successes in the application of complex network theory and algorithms to minerology, fossils and proteins over billions of years of Earth's history, raise expectations that more general graph-based approaches offer the opportunity for new discoveries = needles instead of haystacks. In the past 10 years in the natural sciences there has substantial progress in providing both specialists and non-specialists the ability to describe in machine readable form, geophysical quantities and relations among them in meaningful and natural ways, effectively breaking the prior syntax barrier. The corresponding open-world semantics and reasoning provide higher-level interconnections. That is, semantics provided around the data structures, using open-source tools, allow for discovery at the knowledge level. This presentation will cover the fundamentals of data-rich network analyses for geosciences, provide illustrative examples in mineral evolution and offer future paths for consideration.

The CONCEPTS Global Ice-Ocean Prediction System: Establishing an Environmental Prediction Capability in Canada

NASA Astrophysics Data System (ADS)

Pellerin, Pierre; Smith, Gregory; Testut, Charles-Emmanuel; Surcel Colan, Dorina; Roy, Francois; Reszka, Mateusz; Dupont, Frederic; Lemieux, Jean-Francois; Beaudoin, Christiane; He, Zhongjie; Belanger, Jean-Marc; Deacu, Daniel; Lu, Yimin; Buehner, Mark; Davidson, Fraser; Ritchie, Harold; Lu, Youyu; Drevillon, Marie; Tranchant, Benoit; Garric, Gilles

2015-04-01

Here we describe a new system implemented recently at the Canadian Meteorological Centre (CMC) entitled the Global Ice Ocean Prediction System (GIOPS). GIOPS provides ice and ocean analyses and 10 day forecasts daily at 00GMT on a global 1/4° resolution grid. GIOPS includes a full multivariate ocean data assimilation system that combines satellite observations of sea level anomaly and sea surface temperature (SST) together with in situ observations of temperature and salinity. In situ observations are obtained from a variety of sources including: the Argo network of autonomous profiling floats, moorings, ships of opportunity, marine mammals and research cruises. Ocean analyses are blended with sea ice analyses produced by the Global Ice Analysis System.. GIOPS has been developed as part of the Canadian Operational Network of Coupled Environmental PredicTion Systems (CONCEPTS) tri-departmental initiative between Environment Canada, Fisheries and Oceans Canada and National Defense. The development of GIOPS was made through a partnership with Mercator-Océan, a French operational oceanography group. Mercator-Océan provided the ocean data assimilation code and assistance with the system implementation. GIOPS has undergone a rigorous evaluation of the analysis, trial and forecast fields demonstrating its capacity to provide high-quality products in a robust and reliable framework. In particular, SST and ice concentration forecasts demonstrate a clear benefit with respect to persistence. These results support the use of GIOPS products within other CMC operational systems, and more generally, as part of a Government of Canada marine core service. Impact of a two-way coupling between the GEM atmospheric model and NEMO-CICE ocean-ice model will also be presented.

No evidence for Fabaceae Gametophytic self-incompatibility being determined by Rosaceae, Solanaceae, and Plantaginaceae S-RNase lineage genes.

PubMed

Aguiar, Bruno; Vieira, Jorge; Cunha, Ana E; Vieira, Cristina P

2015-06-02

Fabaceae species are important in agronomy and livestock nourishment. They have a long breeding history, and most cultivars have lost self-incompatibility (SI), a genetic barrier to self-fertilization. Nevertheless, to improve legume crop breeding, crosses with wild SI relatives of the cultivated varieties are often performed. Therefore, it is fundamental to characterize Fabaceae SI system(s). We address the hypothesis of Fabaceae gametophytic (G)SI being RNase based, by recruiting the same S-RNase lineage gene of Rosaceae, Solanaceae or Plantaginaceae SI species. We first identify SSK1 like genes (described only in species having RNase based GSI), in the Trifolium pratense, Medicago truncatula, Cicer arietinum, Glycine max, and Lupinus angustifolius genomes. Then, we characterize the S-lineage T2-RNase genes in these genomes. In T. pratense, M. truncatula, and C. arietinum we identify S-RNase lineage genes that in phylogenetic analyses cluster with Pyrinae S-RNases. In M. truncatula and C. arietinum genomes, where large scaffolds are available, these sequences are surrounded by F-box genes that in phylogenetic analyses also cluster with S-pollen genes. In T. pratense the S-RNase lineage genes show, however, expression in tissues not involved in GSI. Moreover, levels of diversity are lower than those observed for other S-RNase genes. The M. truncatula and C. arietinum S-RNase and S-pollen like genes phylogenetically related to Pyrinae S-genes, are also expressed in tissues other than those involved in GSI. To address if other T2-RNases could be determining Fabaceae GSI, here we obtained a style with stigma transcriptome of Cytisus striatus, a species that shows significant difference on the percentage of pollen growth in self and cross-pollinations. Expression and polymorphism analyses of the C. striatus S-RNase like genes revealed that none of these genes, is the S-pistil gene. We find no evidence for Fabaceae GSI being determined by Rosaceae, Solanaceae, and Plantaginaceae S-RNase lineage genes. There is no evidence that T2-RNase lineage genes could be determining GSI in C. striatus. Therefore, to characterize the Fabaceae S-pistil gene(s), expression analyses, levels of diversity, and segregation analyses in controlled crosses are needed for those genes showing high expression levels in the tissues where GSI occurs.

Supporting health systems in Europe: added value of EU actions?

PubMed

Clemens, Timo; Michelsen, Kai; Brand, Helmut

2014-01-01

Since the start of the economic crisis, the European Union's (EU's) predominant discourse has been austerity and fiscal consolidation. The detrimental effects on Europe's health systems and the health status of its citizens are well described. However, little is known about the emerging EU-level initiatives to support national health systems handle the challenges of efficient care provision and system reorganisation aimed to meet their future needs. This review analyses the manner, conditions and prospects of such EU support. First, health system objectives are increasingly entering the EU health policy agenda. Second, professional and patient mobility provisions may support member states (MS) in copying with crisis related health challenges but can potentially acerbate them at the same time. Third, in recent initiatives health system goals are more closely tied to the EU's economic growth narrative. And fourth, health system issues are taken up in existing EU-level structures for debate and exchange between MS. In addition, the design of some policies may have the potential to intensify socioeconomic and health inequalities rather than ameliorate them.

Stratification of habitats for identifying habitat selection by Merriam's turkeys

Treesearch

Mark A. Rumble; Stanley H. Anderson

1992-01-01

Habitat selection patterns of Merriam’s Turkeys were compared in hierarchical analyses of three levels of habitat stratification. Habitat descriptions in first-level analyses were based on dominant species of vegetation. Habitat descriptions in second-level analyses were based on dominant species of vegetation and overstory canopy cover. Habitat descriptions in third-...

Characterizing Middle Atmospheric Dynamical Variability and its Impact on the Thermosphere/Ionosphere System During Recent Stratospheric Sudden Warmings

NASA Astrophysics Data System (ADS)

McCormack, J. P.; Sassi, F.; Hoppel, K.; Ma, J.; Eckermann, S. D.

2015-12-01

We investigate the evolution of neutral atmospheric dynamics in the 10-100 km altitude range before, during, and after recent stratospheric sudden warmings (SSWs) using a prototype high-altitude version of the Navy Global Environmental Model (NAVGEM), which combines a 4-dimensional variational (4DVAR) data assimilation system with a 3-time-level semi-Lagrangian semi-implicit global forecast model. In addition to assimilating conventional meteorological observations, NAVGEM also assimilates middle atmospheric temperature and constituent observations from both operational and research satellite platforms to provide global synoptic meteorological analyses of winds, temperatures, ozone, and water vapor from the surface to ~90 km. In this study, NAVGEM analyses are used to diagnose the spatial and temporal evolution of the main dynamical drivers in the mesosphere and lower thermosphere (MLT) before, during, and after specific SSW events during the 2009-2013 period when large disturbances were observed in the thermosphere/ionosphere (TI) region. Preliminary findings show strong modulation of the semidiurnal tide in the MLT during the onset of an SSW. To assess the impact of the neutral atmosphere dynamical variability on the TI system, NAVGEM analyses are used to constrain simulations of select SSW events using the specified dynamics (SD) configuration of the extended Whole Atmosphere Community Climate Model (WACCM-X).

Whirl Flutter Stability and Its Influence on the Design of the Distributed Electric Propeller Aircraft X- 57

NASA Technical Reports Server (NTRS)

Hoover, Christian B.; Shen, Jinwei; Kreshock, Andrew R.; Stanford, Bret K.; Piatak, David J.; Heeg, Jennifer

2017-01-01

This paper studies the whirl flutter stability of the NASA experimental electric propulsion aircraft designated the X-57 Maxwell. whirl flutter stability is studied at two flight conditions: sea level at 2700 RPM to represent take-off and landing and 8000 feet at 2250 RPM to represent cruise. Two multibody dynamics analyses are used: CAMRAD II and Dymore. The CAMRAD II model is a semi-span X-57 model with a modal representation for the wing/pylon system. The Dymore model is a semi-span wing with a propeller composed of beam elements for the wing/pylon system that airloads can be applied to. The two multibody dynamics analyses were verified by comparing structural properties between each other and the NASTRAN analysis. For whirl flutter, three design revisions of the wing and pylon mount system are studied. The predicted frequencies and damping ratio of the wing modes show good agreements between the two analyses. Dymore tended to predict a slightly lower damping ratio as velocity increased for all three dynamic modes presented. Whirl flutter for the semi-span model was not present up to 500 knots for the latest design, well above the operating range of the X-57.

Is there enough research output of EU projects available to assess and improve health system performance? An attempt to understand and categorise the output of EU projects conducted between 2002 and 2012.

PubMed

Zander, Britta; Busse, Reinhard

2017-02-22

Adequate performance assessment benefits from the use of disaggregated data to allow a proper evaluation of health systems. Since routinely collected data are usually not disaggregated enough to allow stratified analyses of healthcare needs, utilisation, cost and quality across different sectors, international research projects could fill this gap by exploring means to data collection or even providing individual-level data. The aim of this paper is therefore to (1) study the availability and accessibility of relevant European-funded health projects, and (2) to analyse their contents and methodologies. The European Commission Public Health Projects Database and CORDIS were searched for eligible projects, which were then analysed by information openly available online. Overall, only a few of the 39 identified projects produced data useful for proper performance assessment, due to, for example, lacking available or accessible data, or poor linkage of health status to costs and patient experiences. Other problems were insufficient databases to identify projects and poor communication of project contents and results. A new approach is necessary to improve accessibility to and coverage of data on outcomes, quality and costs of health systems enabling decision-makers and health professionals to properly assess performance.

DNA methylation and exposure to ambient air pollution in two prospective cohorts.

PubMed

Plusquin, Michelle; Guida, Florence; Polidoro, Silvia; Vermeulen, Roel; Raaschou-Nielsen, Ole; Campanella, Gianluca; Hoek, Gerard; Kyrtopoulos, Soterios A; Georgiadis, Panagiotis; Naccarati, Alessio; Sacerdote, Carlotta; Krogh, Vittorio; Bas Bueno-de-Mesquita, H; Monique Verschuren, W M; Sayols-Baixeras, Sergi; Panni, Tommaso; Peters, Annette; Hebels, Dennie G A J; Kleinjans, Jos; Vineis, Paolo; Chadeau-Hyam, Marc

2017-11-01

Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers. However, underlying molecular alterations remain to be further investigated. The aim of this study is to investigate the effects of long-term exposure to air pollutants on (a) average DNA methylation at functional regions and, (b) individual differentially methylated CpG sites. An assumption is that omic measurements, including the methylome, are more sensitive to low doses than hard health outcomes. This study included blood-derived DNA methylation (Illumina-HM450 methylation) for 454 Italian and 159 Dutch participants from the European Prospective Investigation into Cancer and Nutrition (EPIC). Long-term air pollution exposure levels, including NO 2 , NO x , PM 2.5 , PM coarse , PM 10 , PM 2.5 absorbance (soot) were estimated using models developed within the ESCAPE project, and back-extrapolated to the time of sampling when possible. We meta-analysed the associations between the air pollutants and global DNA methylation, methylation in functional regions and epigenome-wide methylation. CpG sites found differentially methylated with air pollution were further investigated for functional interpretation in an independent population (EnviroGenoMarkers project), where (N=613) participants had both methylation and gene expression data available. Exposure to NO 2 was associated with a significant global somatic hypomethylation (p-value=0.014). Hypomethylation of CpG island's shores and shelves and gene bodies was significantly associated with higher exposures to NO 2 and NO x . Meta-analysing the epigenome-wide findings of the 2 cohorts did not show genome-wide significant associations at single CpG site level. However, several significant CpG were found if the analyses were separated by countries. By regressing gene expression levels against methylation levels of the exposure-related CpG sites, we identified several significant CpG-transcript pairs and highlighted 5 enriched pathways for NO 2 and 9 for NO x mainly related to the immune system and its regulation. Our findings support results on global hypomethylation associated with air pollution, and suggest that the shores and shelves of CpG islands and gene bodies are mostly affected by higher exposure to NO 2 and NO x . Functional differences in the immune system were suggested by transcriptome analyses. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer.

PubMed

Dorn, Julia; Gkazepis, Apostolos; Kotzsch, Matthias; Kremer, Marcus; Propping, Corinna; Mayer, Katharina; Mengele, Karin; Diamandis, Eleftherios P; Kiechle, Marion; Magdolen, Viktor; Schmitt, Manfred

2014-01-01

Expression of the kallikrein-related peptidase 7 (KLK7) is dysregulated in ovarian cancer. We assessed KLK7 expression by ELISA and quantitative immunohistochemistry and analyzed its association with clinicopathological parameters and patients' outcome. KLK7 antigen concentrations were determined in tumor tissue extracts of 98 ovarian cancer patients by ELISA. For analysis of KLK7 immunoexpression in ovarian cancer tissue microarrays, a manual quantitative scoring system as well as a software tool for quantitative high-throughput automated image analysis was used. In immunohistochemical analyses, expression levels of KLK7 were not associated with patients' outcome. However, in multivariate analyses, KLK7 antigen levels in tumor tissue extracts were significantly associated with both overall and progression-free survival: ovarian cancer patients with high KLK7 levels had a significantly, 2-fold lower risk of death [hazard ratio (HR)=0.51, 95% confidence interval (CI)=0.29-0.90, p=0.019] or relapse [HR=0.47, 95% CI=0.25-0.91, p=0.024), as compared with patients who displayed low KLK7 levels. Our results indicate that - in contrast to earlier findings - high KLK7 antigen levels in tumor tissue extracts may be associated with a better prognosis of ovarian cancer patients.

Effect of alpha-tocopherol on lipid peroxidation and antioxidant system in fibrosarcoma bearing rats.

PubMed

Vasavi, H; Thangaraju, M; Sachdanandam, P

1994-02-23

The anticarcinogenic activity of alpha-tocopherol (Vitamin E) was tried in fibrosarcoma induced rats through its antioxidative potential. The rate of formation of malondialdehyde (MDA), the end product of lipid peroxidation was analysed in alpha-tocopherol (400 mg/kg body weight) treated and untreated fibrosarcoma bearing rats with respective controls. The levels of non-enzymic antioxidants like, glutathione and vitamin E, and enzymic antioxidants viz., catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and glutathione-S-transferase (GST) were assayed as well. Significantly increased (p < 0.001) level of lipid peroxide was observed with concomitant decreases in the level of enzymic and non-enzymic antioxidants in fibrosarcoma bearing rats when compared with control animals. In alpha-tocopherol supplemented animals, the corrected level of these parameters were observed likely to near normal values. Thus, alpha-tocopherol can be accepted to pose first line of defense mechanism against excessively formed reactive species due to impaired antioxidant systems in fibrosarcoma conditions, that cause membrane damage leading to deleterious effects.

Crush Analyses of Multi-Level Equipment

DOT National Transportation Integrated Search

2006-11-06

Non-linear large deformation crush analyses were conducted on a multi-level cab car typical of those in operation by the Southern California Regional Rail Authority (SCRRA) in California. The motivation for these analyses was a collision, which occur...

Rangeland degradation in savannas of South Africa: spatial patterns of soil and vegetation

NASA Astrophysics Data System (ADS)

Sandhage-Hofmann, Alexandra; Löffler, Jörg; du Preez, Chris; Kotzé, Elmarie; Weijers, Stef; Wundram, Dirk; Zacharias, Maximilan; Amelung, Wulf

2017-04-01

Extensive bush encroachment by Acacia mellifera and associated woody species at semi-arid and arid sites are the most notable forms of rangeland degradation in savannas of South Africa. Concerns are growing over the threat of suppression and loss of nutritious perennial grass species. Grazing and different rangeland management systems (communal and freehold) are considered to be of major importance for degradation, but the process of encroachment is not restricted to communal land. A vegetation change is mostly accompanied by changes in soil properties, where soils in savanna systems can profit from woody species due to litter fall, root distribution, shadow and animal resting time. Savannas are very heterogeneous systems with high spatial variation of patches with wood, herbaceous species and bare ground. We hypothesized that the spatial patterns of soil properties in South Africás rangelands are controlled by present or past vegetation, modulated by the tenure systems with higher rangeland degradation in communal areas. To test this, we sampled soils at communal and commercial land in the Kuruman area of South Africa with the following design: three farms per tenure system, 6 randomly chosen plots (100x100m) per farm, and 25 soil samples (0-10 cm) per plot, each in a 5x5m sampling area. At every sampling point, information of overlying vegetation was recorded (species or bare soil, canopy size, height). For each sampling area, if present, trees/ shrubs were sampled and their ages estimated through the counting of annual growth rings. For each plot, high resolution UAV aerial photos were taken to evaluate the extent of bush encroachment. Analyses involved main physical and chemical soil parameters and isotopic analyses. The results of a rough aerial image classification (grass, woody species, bare ground) revealed significant differences between the tenure systems with higher coverage of bare ground and shrubs at communal farms, and higher grass cover at commercial farms. The tenure systems had no differences in main texture classes of the soils, but significant differences in the composition of the sand fraction, with higher levels of fine sand and lower levels of coarse sand in communal farms. The chemical soil properties showed a high variability both within and between the farms, with much higher variability within communal than commercial farms. Additionally, concentrations of nitrogen, carbon, calcium and pH were significant higher in communal farms. Isotopic analyses in soils showed significant differences for 15N with higher levels in commercial farms. Different photosynthetic pathways are responsible for differences found in 13C values, with higher levels (-16-18‰) in C4-grassland and lower values (-22-26‰) in soils under Acacia (C3). We found relationships between soil properties and species or bare ground, where differences in texture likely interact with both, vegetation cover and soil properties.

Individual and community risk factors and sexually transmitted diseases among arrested youths: a two level analysis.

PubMed

Dembo, Richard; Belenko, Steven; Childs, Kristina; Wareham, Jennifer; Schmeidler, James

2009-08-01

High rates of infection for chlamydia and gonorrhea have been noted among youths involved in the juvenile justice system. Although both individual and community-level factors have been found to be associated with sexually transmitted disease (STD) risk, their relative importance has not been tested in this population. A two-level logistic regression analysis was completed to assess the influence of individual-level and community-level predictors on STD test results among arrested youths processed at a centralized intake facility. Results from weighted two level logistic regression analyses (n = 1,368) indicated individual-level factors of gender (being female), age, race (being African American), and criminal history predicted the youths' positive STD status. For the community-level predictors, concentrated disadvantage significantly and positively predicted the youths' STD status. Implications of these findings for future research and public health policy are discussed.

A Significant Role for Renewables in a Low-Carbon Energy Economy?

NASA Astrophysics Data System (ADS)

Newmark, R. L.

2015-12-01

Renewables currently make up a small (but growing) fraction of total U.S. electricity generation. In some regions, renewable growth has resulted in instantaneous penetration levels of wind and solar in excess of 60% of demand. With decreasing costs, abundant resource potential and low carbon emissions and water requirements, wind and solar are increasingly becoming attractive new generation options. However, factors such as resource variability and geographic distribution of prime resources raise questions regarding the extent to which our power system can rely on variable generation resources. Here, we describe scenario analyses designed to tackle engineering and economic challenges associated with variable generation, along with insights derived from research results. These analyses demonstrate the operability of high renewable systems and quantify some of the engineering challenges (and solutions) associated with maintaining reliability. Key questions addressed include the operational and economic impacts of increasing levels of variable generation on the U.S. power system. Since reliability and economic efficiency are measured across a variety of time frames, and with a variety of metrics, a suite of tools addressing different system impacts are used to understand how new resources affect incumbent resources and operational practices. We summarize a range of modeled scenarios, focusing on ones with 80% RE in the United States and >30% variable wind and solar in the East and the West. We also summarize the environmental impacts and benefits estimated for these and similar scenarios. Results provide key insights to inform the technical, operational and regulatory evolution of the U.S. power system. This work is extended internationally through the 21st Century Power Partnership's collaborations on power system transformation, with active collaboration in Canada, Mexico, India, China and South Africa, among others.

Use of GIS in visualization of work-related health problems.

PubMed

Delaunay, M; Van der Westhuizen, H; Godard, V; Agius, R; Le Barbier, M; Godderis, L; Bonneterre, V

2015-11-01

Occupational health and safety (OHS) information is often complex, diverse and unstructured and suffers from a lack of integration which usually precludes any systemic insight of the situation. To analyse to what extent the use of geographical information systems (GISs) can help to integrate, analyse and present OHS data in a comprehensive and communicable way relevant for surveillance purposes. We first developed a 'macro-approach' (from national to local level), mapping data related to economic activity (denominator of active workers displayed by activity sectors), as well as work-related ill-health (numerators of workers suffering from work-related ill-health). The latter data are composed of compensated occupational diseases on the one hand and work-related diseases investigated by specialized clinics on the other hand. Then, a 'micro-approach' was worked out, integrating at a plant level, using computer-aided drawing, occupational risks data and OHS surveillance data (e.g. use of medication and sickness absence data). At the macro-level, microelectronics companies and workers were mapped at different scales. For the first time, we were able to compare, up to the enterprise level, complementary data showing different pictures of work-related ill-health, allowing a better understanding of OH issues in this sector. At the micro-level, new information arose from the integration of risk assessment data and medical data. This work illustrates to what extent GIS is a promising tool in the OHS field, and discusses related challenges (technical, ethical, biases and interpretation) and research perspectives. © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

The progressivity of health-care financing in Kenya.

PubMed

Munge, Kenneth; Briggs, Andrew Harvey

2014-10-01

Health-care financing should be equitable. In many developing countries such as Kenya, changes to health-care financing systems are being implemented as a means of providing equitable access to health care with the aim of attaining universal coverage. Vertical equity means that people of dissimilar ability to pay make dissimilar levels of contribution to the health-care financing system. Vertical equity can be analysed by measuring progressivity. The aim of this study was to analyse progressivity by measuring deviations from proportionality in the relationship between sources of health-care financing and ability to pay using Kakwani indices applied to data from the Kenya Household Health Utilisation and Expenditure Survey 2007. Concentration indices and Kakwani indices were obtained for the sources of health-care financing: direct and indirect taxes, out of pocket (OOP) payments, private insurance contributions and contributions to the National Hospital Insurance Fund. The bootstrap method was used to analyse the sensitivity of the Kakwani index to changes in the equivalence scale or the use of an alternative measure of ability to pay. The overall health-care financing system was regressive. Out of pocket payments were regressive with all other payments being proportional. Direct taxes, indirect taxes and private insurance premiums were sensitive to the use of income as an alternative measure of ability to pay. However, the overall finding of a regressive health-care system remained. Reforms to the Kenyan health-care financing system are required to reduce dependence on out of pocket payments. The bootstrap method can be used in determining the sensitivity of the Kakwani index to various assumptions made in the analysis. Further analyses are required to determine the equity of health-care utilization and the effect of proposed reforms on overall equity of the Kenyan health-care system. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine © The Author 2013; all rights reserved.

Effective model development of internal auditors in the village financial institution

NASA Astrophysics Data System (ADS)

Arsana, I. M. M.; Sugiarta, I. N.

2018-01-01

Designing an effective audit system is complex and challenging, and a focus on examining how internal audit drive improvement in three core performance dimensions ethicality, efficiency, and effectiveness in organization is needed. The problem of research is how the desain model and peripheral of supporter of effective supervation Village Credit Institution? Research of objectives is yielding the desain model and peripheral of supporter of effective supervation Village Credit Institution. Method Research use data collecting technique interview, observation and enquette. Data analysis, data qualitative before analysed to be turned into quantitative data in the form of scale. Each variable made to become five classificat pursuant to scale of likert. Data analysed descriptively to find supervation level, Structural Equation Model (SEM) to find internal and eksternal factor. So that desain model supervation with descriptive analysis. Result of research desain model and peripheral of supporter of effective supervation Village Credit Institution. The conclusion desain model supported by three sub system: sub system institute yield body supervisor of Village Credit Institution, sub system standardization and working procedure yield standard operating procedure supervisor of Village Credit Institution, sub system education and training yield supervisor professional of Village Credit Institution.

Parts and Components Reliability Assessment: A Cost Effective Approach

NASA Technical Reports Server (NTRS)

Lee, Lydia

2009-01-01

System reliability assessment is a methodology which incorporates reliability analyses performed at parts and components level such as Reliability Prediction, Failure Modes and Effects Analysis (FMEA) and Fault Tree Analysis (FTA) to assess risks, perform design tradeoffs, and therefore, to ensure effective productivity and/or mission success. The system reliability is used to optimize the product design to accommodate today?s mandated budget, manpower, and schedule constraints. Stand ard based reliability assessment is an effective approach consisting of reliability predictions together with other reliability analyses for electronic, electrical, and electro-mechanical (EEE) complex parts and components of large systems based on failure rate estimates published by the United States (U.S.) military or commercial standards and handbooks. Many of these standards are globally accepted and recognized. The reliability assessment is especially useful during the initial stages when the system design is still in the development and hard failure data is not yet available or manufacturers are not contractually obliged by their customers to publish the reliability estimates/predictions for their parts and components. This paper presents a methodology to assess system reliability using parts and components reliability estimates to ensure effective productivity and/or mission success in an efficient manner, low cost, and tight schedule.

Regional Data Assimilation Using a Stretched-Grid Approach and Ensemble Calculations

NASA Technical Reports Server (NTRS)

Fox-Rabinovitz, M. S.; Takacs, L. L.; Govindaraju, R. C.; Atlas, Robert (Technical Monitor)

2002-01-01

The global variable resolution stretched grid (SG) version of the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS) incorporating the GEOS SG-GCM (Fox-Rabinovitz 2000, Fox-Rabinovitz et al. 2001a,b), has been developed and tested as an efficient tool for producing regional analyses and diagnostics with enhanced mesoscale resolution. The major area of interest with enhanced regional resolution used in different SG-DAS experiments includes a rectangle over the U.S. with 50 or 60 km horizontal resolution. The analyses and diagnostics are produced for all mandatory levels from the surface to 0.2 hPa. The assimilated regional mesoscale products are consistent with global scale circulation characteristics due to using the SG-approach. Both the stretched grid and basic uniform grid DASs use the same amount of global grid-points and are compared in terms of regional product quality.

Closed Loop Requirements and Analysis Management

NASA Technical Reports Server (NTRS)

Lamoreaux, Michael; Verhoef, Brett

2015-01-01

Effective systems engineering involves the use of analysis in the derivation of requirements and verification of designs against those requirements. The initial development of requirements often depends on analysis for the technical definition of specific aspects of a product. Following the allocation of system-level requirements to a product's components, the closure of those requirements often involves analytical approaches to verify that the requirement criteria have been satisfied. Meanwhile, changes that occur in between these two processes need to be managed in order to achieve a closed-loop requirement derivation/verification process. Herein are presented concepts for employing emerging Team center capabilities to jointly manage requirements and analysis data such that analytical techniques are utilized to effectively derive and allocate requirements, analyses are consulted and updated during the change evaluation processes, and analyses are leveraged during the design verification process. Recommendations on concept validation case studies are also discussed.

Evaluation of the impact of intervention programmes on education organisations: Application to a Quality Management System.

PubMed

Fernández-Díaz, Mª Jose; Rodríguez-Mantilla, Jesús Miguel; Jover-Olmeda, Gonzalo

2017-08-01

This paper analyses the importance of evaluating the various components of the programmes or actions carried out by education organisations. It highlights the need to assess the impact of the intervention on the organisation and consider how changes are consolidated over time in interaction with the context. We propose an impact evaluation model and as an example have chosen the implementation of Quality Management Systems in schools. The paper analyses the results obtained in 40 schools in three regions (Spanish Autonomous Communities) with varying levels of implementation. The results show overall impact on these education centres as the teachers and management teams of the centres perceive it. This impact is more evident in some of the dimensions considered in the study than in others. The results also confirm the differences between regional contexts. Copyright © 2017 Elsevier Ltd. All rights reserved.

Regional water coefficients for U.S. industrial sectors

DOE PAGES

Boero, Riccardo; Pasqualini, Donatella

2017-09-14

Designing policies for water systems management requires the capability to assess the economic impacts of water availability and to effectively couple water withdrawals by human activities with natural hydrologic dynamics. At the core of any scientific approach to these issues there is the estimation of water withdrawals by industrial sectors in the form of water coefficients, which are measurements of the quantity of water withdrawn per dollar of GDP or output. Here, we focus on the contiguous United States and on the estimation of water coefficients for regional scale analyses. We first compare an established methodology for the estimation ofmore » national water coefficients with a parametric one we propose. Second, we introduce a method to estimate water coefficients at the level of ecological regions and we discuss how they reduce possible biases in regional analyses of water systems. Finally, we discuss advantages and limits of regional water coefficients.« less

Regional water coefficients for U.S. industrial sectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boero, Riccardo; Pasqualini, Donatella

Designing policies for water systems management requires the capability to assess the economic impacts of water availability and to effectively couple water withdrawals by human activities with natural hydrologic dynamics. At the core of any scientific approach to these issues there is the estimation of water withdrawals by industrial sectors in the form of water coefficients, which are measurements of the quantity of water withdrawn per dollar of GDP or output. Here, we focus on the contiguous United States and on the estimation of water coefficients for regional scale analyses. We first compare an established methodology for the estimation ofmore » national water coefficients with a parametric one we propose. Second, we introduce a method to estimate water coefficients at the level of ecological regions and we discuss how they reduce possible biases in regional analyses of water systems. Finally, we discuss advantages and limits of regional water coefficients.« less

Rates of traumatization and psychopathology in criminal justice-involved women.

PubMed

Salina, Doreen D; Figge, Caleb; Ram, Daphna; Jason, Leonard A

2017-01-01

Prior research has consistently found disproportionate rates of traumatization and psychopathology in criminal justice-involved women. The current study aimed to characterize rates of traumatization, psychopathology, and diagnostic comorbidity in women involved with the justice system. Furthermore, this study examined the role of posttraumatic stress symptoms in the association between traumatic events and levels of self-esteem. Participants were 185 women from the Chicagoland area with current or previous (past 2 years) involvement with the criminal justice system. Results confirmed disproportionate rates of trauma experiences and psychopathology in this population, and logistic regression analyses indicated that rates of traumatization predicted diagnostic comorbidity. Analyses indicated an indirect effect of posttraumatic stress in the association between traumatic experiences and self-esteem. Findings highlight the importance of assessing and targeting both trauma experiences and posttraumatic stress in justice-involved women to optimize prevention and intervention efforts.

Structural design considerations for a Personnel Launch System

NASA Technical Reports Server (NTRS)

Bush, Lance B.; Lentz, Christopher A.; Robinson, James C.; Macconochie, Ian O.

1990-01-01

A vehicle capable of performing the transfer of eight people to and from the Space Station Freedom is currently in the conceptual/preliminary design stages at the NASA Langley Research Center. Structural definition of this Personnel Launch System (PLS) and the considerations leading to it are described. Issues such as cost, technology level, human factors, and maintainability are used as guidelines for the structural definition. A synergistic design technique involving aerodynamics, performance, mission, packaging, and weights and sizing analyses is utilized to evaluate the structural design. A closed-loop design is achieved when the mission requirements are met by each previously mentioned analysis for a particular vehicle weight. Although satisfactory, the structural concept presented herein is not to be treated as a final answer, but one promising solution. An examination of alternative designs and more detailed analyses can be undertaken in order to identify design inadequacies and more efficient approaches.

Evaluating the influence of septic systems and watershed characteristics on stream faecal pollution in suburban watersheds in Georgia, USA.

PubMed

Sowah, R; Zhang, H; Radcliffe, D; Bauske, E; Habteselassie, M Y

2014-11-01

To determine the impact of septic systems on water quality and in so doing identify watershed level characteristics that influence septic system impact. Water samples were collected from streams in 24 well-characterized watersheds during baseflow to analyse for the levels of faecal indicators Escherichia coli and enterococci. The watersheds represent a gradient of land-use conditions from low to high density of septic systems, as well as developed to undeveloped uses. Our findings indicate statistically significant interaction between septic density and season for enterococci count (P = 0·005) and stream yield (P = 0·04). Seasonal variations in bacterial count and stream yield were also observed, with significant differences between spring-winter and summer-winter. Results from multiple linear regression models suggest that watershed characteristics (septic system density, median distance of septic systems to stream, per cent developed area and forest cover) and water temperature could explain approximately half (R(2) = 0·50) of the variability in bacterial count and yield in spring and summer. There is a significant positive relationship between septic system density and faecal pollution levels. However, this relationship is season dependent and is influenced by watershed level characteristics such as median distance of septic systems from streams, per cent developed area and forest cover. This study confirms the significant impact of septic systems on faecal pollution during baseflow and provides the tools that will enable effective pollution monitoring at the watershed scale. © 2014 The Society for Applied Microbiology.

Coastal wetlands, sea level, and the dimensions of geomorphic resilience

NASA Astrophysics Data System (ADS)

Phillips, Jonathan D.

2018-03-01

Geomorphic system resilience is often perceived as an intrinsic property of system structure and interactions but is also related to idiosyncratic place and history factors. The importance of geographical and historical circumstances makes it difficult to generate categorical statements about geomorphic resilience. However, network-based analyses of system structure can be used to determine the dynamical stability (= resilience) based on generally applicable relationships and to determine scenarios of stability or instability. These provide guidelines for assessing place and history factors to assess resilience. A model of coastal wetlands is analyzed, based on interactions among relative sea level, wetland surface elevation, hydroperiod, vegetation, and sedimentation. The system is generally (but not always) dynamically unstable and non-resilient. Because of gradients of environmental factors and patchy distributions of microtopography and vegetation, a coastal wetland landscape may have extensive local variations in stability/resilience and in the key relationships that trigger instabilities. This is illustrated by a case study where dynamically unstable fragmentation is found in two nearby coastal wetlands in North Carolina's Neuse River estuary-Otter Creek Mouth and Anderson Creek. Neither is keeping pace with relative sea level rise, and both show unstable state transitions within the wetland system; but locally stable relationships exist within the wetland systems.

Airspace Systems Program: Next Generation Air Transportation System, NextGen Systems Analysis, Integration and Evaluation Project. Version 1.0; Project Plan

NASA Technical Reports Server (NTRS)

Quon, Leighton

2010-01-01

The key objectives of the NASA ASP are to: Improve mobility, capacity efficiency and access of the airspace system. Improve collaboration, predictability, and flexibility for the airspace users. Enable accurate modeling and simulation of air transportation systems. Accommodate operations of all classes of aircraft. Maintain system safety and environmental protection. In support of these program objectives, the major goal of the NextGen-SAIE Project is to enable the transition of key capacity and efficiency improvements to the NAS. Since many aspects of the NAS are unique to specific airport or airspace environments, demand on various parts of the NAS is not expected to increase equally as system demand grows. SAIE will provide systems level analysis of the NAS characteristics, constraints, and demands such that a suite of capacity-increasing concepts and technologies for system solutions are enabled and facilitated. The technical objectives in support of this goal are the following: Integration, evaluation, and transition of more mature concepts and technologies in an environment that faithfully emulates real-world complexities. Interoperability research and analysis of ASP technologies across ATM functions is performed to facilitate integration and take ASP concepts and technologies to higher Technology Readiness Level (TRL). Analyses are conducted on the program s concepts to identify the system benefits or impacts. System level analysis is conducted to increase understanding of the characteristics and constraints of airspace system and its domains.

Uncertainty management, spatial and temporal reasoning, and validation of intelligent environmental decision support systems

USGS Publications Warehouse

Sànchez-Marrè, Miquel; Gilbert, Karina; Sojda, Rick S.; Steyer, Jean Philippe; Struss, Peter; Rodríguez-Roda, Ignasi; Voinov, A.A.; Jakeman, A.J.; Rizzoli, A.E.

2006-01-01

There are inherent open problems arising when developing and running Intelligent Environmental Decision Support Systems (IEDSS). During daily operation of IEDSS several open challenge problems appear. The uncertainty of data being processed is intrinsic to the environmental system, which is being monitored by several on-line sensors and off-line data. Thus, anomalous data values at data gathering level or even uncertain reasoning process at later levels such as in diagnosis or decision support or planning can lead the environmental process to unsafe critical operation states. At diagnosis level or even at decision support level or planning level, spatial reasoning or temporal reasoning or both aspects can influence the reasoning processes undertaken by the IEDSS. Most of Environmental systems must take into account the spatial relationships between the environmental goal area and the nearby environmental areas and the temporal relationships between the current state and the past states of the environmental system to state accurate and reliable assertions to be used within the diagnosis process or decision support process or planning process. Finally, a related issue is a crucial point: are really reliable and safe the decisions proposed by the IEDSS? Are we sure about the goodness and performance of proposed solutions? How can we ensure a correct evaluation of the IEDSS? Main goal of this paper is to analyse these four issues, review some possible approaches and techniques to cope with them, and study new trends for future research within the IEDSS field.

Status of a standard for neutron skyshine calculation and measurement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westfall, R.M.; Wright, R.Q.; Greenborg, J.

1990-01-01

An effort has been under way for several years to prepare a draft standard, ANS-6.6.2, Calculation and Measurement of Direct and Scattered Neutron Radiation from Contained Sources Due to Nuclear Power Operations. At the outset, the work group adopted a three-phase study involving one-dimensional analyses, a measurements program, and multi-dimensional analyses. Of particular interest are the neutron radiation levels associated with dry-fuel storage at reactor sites. The need for dry storage has been investigated for various scenarios of repository and monitored retrievable storage (MRS) facilities availability with the waste stream analysis model. The concern is with long-term integrated, low-level dosesmore » at long distances from a multiplicity of sources. To evaluate the conservatism associated with one-dimensional analyses, the work group has specified a series of simple problems. Sources as a function of fuel exposure were determined for a Westinghouse 17 x 17 pressurized water reactor assembly with the ORIGEN-S module of the SCALE system. The energy degradation of the 35 GWd/ton U sources was determined for two generic designs of dry-fuel storage casks.« less

Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity.

PubMed

Morillas-de-Laguno, Pablo; Vargas-Hitos, José A; Rosales-Castillo, Antonio; Sáez-Urán, Luis Manuel; Montalbán-Méndez, Cristina; Gavilán-Carrera, Blanca; Navarro-Mateos, Carmen; Acosta-Manzano, Pedro; Delgado-Fernández, Manuel; Sabio, José M; Ortego-Centeno, Norberto; Callejas-Rubio, José L; Soriano-Maldonado, Alberto

2018-01-01

To examine the association of objectively measured physical activity (PA) intensity levels and sedentary time with arterial stiffness in women with systemic lupus erythematosus (SLE) with mild disease activity and to analyze whether participants meeting the international PA guidelines have lower arterial stiffness than those not meeting the PA guidelines. The study comprised 47 women with SLE (average age 41.2 [standard deviation 13.9]) years, with clinical and treatment stability during the 6 months prior to the study. PA intensity levels and sedentary time were objectively measured with triaxial accelerometry. Arterial stiffness was assessed through pulse wave velocity, evaluated by Mobil-O-Graph® 24h pulse wave analysis monitor. The average time in moderate to vigorous PA in bouts of ≥10 consecutive minutes was 135.1±151.8 minutes per week. There was no association of PA intensity levels and sedentary time with arterial stiffness, either in crude analyses or after adjusting for potential confounders. Participants who met the international PA guidelines did not show lower pulse wave velocity than those not meeting them (b = -0.169; 95% CI: -0.480 to 0.143; P = 0.280). Our results suggest that PA intensity levels and sedentary time are not associated with arterial stiffness in patients with SLE. Further analyses revealed that patients with SLE meeting international PA guidelines did not present lower arterial stiffness than those not meeting the PA guidelines. Future prospective research is needed to better understand the association of PA and sedentary time with arterial stiffness in patients with SLE.

The Grandest Genetic Experiment Ever Performed on Man? - A Y-Chromosomal Perspective on Genetic Variation in India.

PubMed

Carvalho-Silva, Denise R; Tyler-Smith, Chris

2008-05-01

We have analysed Y-chromosomal data from Indian caste, Indian tribal and East Asian populations in order to investigate the impact of the caste system on male genetic variation. We find that variation within populations is lower in India than in East Asia, while variation between populations is overall higher. This observation can be explained by greater subdivision within the Indian population, leading to more genetic drift. However, the effect is most marked in the tribal populations, and the level of variation between caste populations is similar to the level between Chinese populations. The caste system has therefore had a detectable impact on Y-chromosomal variation, but this has been less strong than the influence of the tribal system, perhaps because of larger population sizes in the castes, more gene flow or a shorter period of time.

An Assessment of Irrigation Technology Performance in the Southern San Joaquin Valley of California

NASA Astrophysics Data System (ADS)

Vaux, H. J., Jr.; Handley, Dale F.; Giboney, Paul M.

1990-01-01

Seasonal applied water measurements were obtained for 1710 irrigated fields in the southern San Joaquin Valley of California. Most of the fields were planted to one of five major crops: citrus, almonds, grapes, cotton, and small grains. These crops were irrigated with a wide array of irrigation technologies, including drip, sprinkler, furrows with tailwater reuse facilities, conventional furrows, and border irrigation systems. The data were analyzed within an accounting framework to standardize for a variety of climatic and cultural variations. Analyses of the mean depths of applied water by crop and irrigation technology and of the standardized results reveal that drip irrigation systems were associated with the lowest levels of applied water on permanent crops and that the levels of water applied with sprinklers did not differ significantly from those applied with surface systems on either permanent or annual crops.

MPD Thruster Performance Analytic Models

NASA Technical Reports Server (NTRS)

Gilland, James; Johnston, Geoffrey

2003-01-01

Magnetoplasmadynamic (MPD) thrusters are capable of accelerating quasi-neutral plasmas to high exhaust velocities using Megawatts (MW) of electric power. These characteristics make such devices worthy of consideration for demanding, far-term missions such as the human exploration of Mars or beyond. Assessment of MPD thrusters at the system and mission level is often difficult due to their status as ongoing experimental research topics rather than developed thrusters. However, in order to assess MPD thrusters utility in later missions, some adequate characterization of performance, or more exactly, projected performance, and system level definition are required for use in analyses. The most recent physical models of self-field MPD thrusters have been examined, assessed, and reconfigured for use by systems and mission analysts. The physical models allow for rational projections of thruster performance based on physical parameters that can be measured in the laboratory. The models and their implications for the design of future MPD thrusters are presented.

MPD Thruster Performance Analytic Models

NASA Technical Reports Server (NTRS)

Gilland, James; Johnston, Geoffrey

2007-01-01

Magnetoplasmadynamic (MPD) thrusters are capable of accelerating quasi-neutral plasmas to high exhaust velocities using Megawatts (MW) of electric power. These characteristics make such devices worthy of consideration for demanding, far-term missions such as the human exploration of Mars or beyond. Assessment of MPD thrusters at the system and mission level is often difficult due to their status as ongoing experimental research topics rather than developed thrusters. However, in order to assess MPD thrusters utility in later missions, some adequate characterization of performance, or more exactly, projected performance, and system level definition are required for use in analyses. The most recent physical models of self-field MPD thrusters have been examined, assessed, and reconfigured for use by systems and mission analysts. The physical models allow for rational projections of thruster performance based on physical parameters that can be measured in the laboratory. The models and their implications for the design of future MPD thrusters are presented.

The evolution of the health system outcomes in Central and Eastern Europe and their association with social, economic and political factors: an analysis of 25 years of transition.

PubMed

Romaniuk, Piotr; Szromek, Adam R

2016-03-17

After the fall of communism, the countries of Central and Eastern Europe started the process of political, economic, and social transformation. In health system the reform directions were often similar, despite differences in transition dynamics and the degree of government determination to implement reforms. Nonetheless, for most post-communist countries, there is a gap in evidence regarding the effectiveness of implemented reforms and their impact on health system performance. The presented study attempts to analyse and evaluate the results of health reforms in CEE countries with regard to their influence on health system outcomes. We also analysed the external and internal health system environments during the transition period to determine the factors affecting the effectiveness of health reforms. We compared the indicators of population health status, lifestyle, occupational safety issues and health system resources in 21 post-communist countries between sub-periods across the entire transition period at the aggregate level. The dynamics of change in health system outcomes in individual countries, as well as between countries, was also compared. Finally, we analysed the correlations between health system outcomes gathered into one synthetic measure and factors considered as potential determinants affecting the effectiveness of health reforms. The analyses were performed based on one-dimensional, two-dimensional and multidimensional statistical methods. The data were retrieved from the international databases, such as WHO, World Bank, International Labour Organization, World Value Survey and the European Social Survey. Among the factors positively stimulating improvements in health system outcomes were the total expenditure on health and a lower financial burden on patients, but primarily they were determined by the broader economic context of the country. Another finding was that better initial position positively determined health system outcomes at later stages, but did not affect the degree of improvements. Countries that embarked on comprehensive reforms early on tended to achieve the greatest improvements in health system outcomes. Poorer countries may have only limited ability to improve health system outcomes by committing more financial resources to the health system. Progress can still be made in terms of health behaviours, since policies to address these have so far been insufficient or ineffective.

Data Assimilation and Regional Forecasts using Atmospheric InfraRed Sounder (AIRS) Profiles

NASA Technical Reports Server (NTRS)

Zabodsky, Brad; Chou, Shih-Hung; Jedlovec, Gary J.

2009-01-01

In data sparse regions, remotely-sensed observations can be used to improve analyses, which in turn should lead to better forecasts. One such source comes from the Atmospheric Infrared Sounder (AIRS), which, together with the Advanced Microwave Sounding Unit (AMSU), provides temperature and moisture profiles with an accuracy comparable to that of radionsondes. The purpose of this poster is to describe a procedure to optimally assimilate AIRS thermodynamic profiles, obtained from the version 5.0 Earth Observing System (EOS) science team retrieval algorithm, into a regional configuration of the Weather Research and Forecasting (WRF) model using WRF-Var. The poster focuses on development of background error covariances for the regional domain and background field type, a methodology for ingesting AIRS profiles as separate over-land and over-water retrievals with different error characteristics, and utilization of level-by-level quality indicators to select only the highest quality data. The assessment of the impact of the AIRS profiles on WRF-Var analyses will focus on intelligent use of the quality indicators, optimized tuning of the WRF-Var, and comparison of analysis soundings to radiosondes. The analyses are used to conduct a month-long series of regional forecasts over the continental U.S. The long-term impact of AIRS profiles on forecast will be assessed against NAM analyses and stage IV precipitation data.

A Comparison of Five Numerical Weather Prediction Analysis Climatologies in Southern High Latitudes.

NASA Astrophysics Data System (ADS)

Connolley, William M.; Harangozo, Stephen A.

2001-01-01

In this paper, numerical weather prediction analyses from four major centers are compared-the Australian Bureau of Meteorology (ABM), the European Centre for Medium-Range Weather Forecasts (ECMWF), the U.S. National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR), and The Met. Office (UKMO). Two of the series-ECMWF reanalysis (ERA) and NCEP-NCAR reanalysis (NNR)-are `reanalyses'; that is, the data have recently been processed through a consistent, modern analysis system. The other three-ABM, ECMWF operational (EOP), and UKMO-are archived from operational analyses.The primary focus in this paper is on the period of 1979-93, the period used for the reanalyses, and on climatology. However, ABM and NNR are also compared for the period before 1979, for which the evidence tends to favor NNR. The authors are concerned with basic variables-mean sea level pressure, height of the 500-hPa surface, and near-surface temperature-that are available from the basic analysis step, rather than more derived quantities (such as precipitation), which are available only from the forecast step.Direct comparisons against station observations, intercomparisons of the spatial pattern of the analyses, and intercomparisons of the temporal variation indicate that ERA, EOP, and UKMO are best for sea level pressure;that UKMO and EOP are best for 500-hPa height; and that none of the analyses perform well for near-surface temperature.

Profiling oil sands mixtures from industrial developments and natural groundwaters for source identification.

PubMed

Frank, Richard A; Roy, James W; Bickerton, Greg; Rowland, Steve J; Headley, John V; Scarlett, Alan G; West, Charles E; Peru, Kerry M; Parrott, Joanne L; Conly, F Malcolm; Hewitt, L Mark

2014-01-01

The objective of this study was to identify chemical components that could distinguish chemical mixtures in oil sands process-affected water (OSPW) that had potentially migrated to groundwater in the oil sands development area of northern Alberta, Canada. In the first part of the study, OSPW samples from two different tailings ponds and a broad range of natural groundwater samples were assessed with historically employed techniques as Level-1 analyses, including geochemistry, total concentrations of naphthenic acids (NAs) and synchronous fluorescence spectroscopy (SFS). While these analyses did not allow for reliable source differentiation, they did identify samples containing significant concentrations of oil sands acid-extractable organics (AEOs). In applying Level-2 profiling analyses using electrospray ionization high resolution mass spectrometry (ESI-HRMS) and comprehensive multidimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOF/MS) to samples containing appreciable AEO concentrations, differentiation of natural from OSPW sources was apparent through measurements of O2:O4 ion class ratios (ESI-HRMS) and diagnostic ions for two families of suspected monoaromatic acids (GC × GC-TOF/MS). The resemblance between the AEO profiles from OSPW and from 6 groundwater samples adjacent to two tailings ponds implies a common source, supporting the use of these complimentary analyses for source identification. These samples included two of upward flowing groundwater collected <1 m beneath the Athabasca River, suggesting OSPW-affected groundwater is reaching the river system.

Characterization of biofilm in 200W fluidized bed reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Michelle H.; Saurey, Sabrina D.; Lee, Brady D.

2014-09-29

Contaminated groundwater beneath the 200 West Area at the Hanford Site in Southeast Washington is currently being treated using a pump and treat system to remove organics, inorganics, radionuclides, and metals. A granular activated carbon-based fluidized bed reactor (FBR) has been added to remove nitrate, hexavalent chromium and carbon tetrachloride. Initial analytical results indicated the microorganisms effectively reduced many of the contaminants to less than cleanup levels. However shortly thereafter operational upsets of the FBR include carbon carry over, over production of microbial extracellular polymeric substance (biofilm) materials, and over production of hydrogen sulfide. As a result detailed investigations weremore » undertaken to understand the functional diversity and activity of the microbial community present in the FBR over time. Molecular analyses including terminal restriction fragment length polymorphism analysis, quantitative polymerase chain reaction and fluorescent in situ hybridization analyses were performed on the microbial community extracted from the biofilm within the bed and from the inoculum, to determine functional dynamics of the FBR bed over time and following operational changes. Findings from these analyses indicated: 1) the microbial community within the bed was completely different than community used for inoculation, and was likely from the groundwater; 2) analyses early in the testing showed an FBR community dominated by a few Curvibacter and Flavobacterium species; 3) the final sample taken indicated that the microbial community in the FBR bed had become more diverse; and 4) qPCR analyses indicated that bacteria involved in nitrogen cycling, including denitrifiers and anaerobic ammonia oxidizing bacteria, were dominant in the bed. These results indicate that molecular tools can be powerful for determining functional diversity within FBR type reactors. Coupled with micronutrient, influent and effluent chemistry evaluations, a more complete understanding of the balance between system additions (nutrients, groundwater) and biology can be achieved, thus increasing long-term predictions of performance. These analyses uniquely provide information that can be used in optimizing the overall performance, efficiency, and stability of the system both in real time as well as over the long-term, as the system design is altered or improved and/or new streams are added.« less

Analysis of a spacecraft life support system for a Mars mission.

PubMed

Czupalla, M; Aponte, V; Chappell, S; Klaus, D

2004-01-01

This report summarizes a trade study conducted as part of the Fall 2002 semester Spacecraft Life Support System Design course (ASEN 5116) in the Aerospace Engineering Sciences Department at the University of Colorado. It presents an analysis of current life support system technologies and a preliminary design of an integrated system for supporting humans during transit to and on the surface of the planet Mars. This effort was based on the NASA Design Reference Mission (DRM) for the human exploration of Mars [NASA Design Reference Mission (DRM) for Mars, Addendum 3.0, from the world wide web: http://exploration.jsc.nasa.gov/marsref/contents.html.]. The integrated design was broken into four subsystems: Water Management, Atmosphere Management, Waste Processing, and Food Supply. The process started with the derivation of top-level requirements from the DRM. Additional system and subsystem level assumptions were added where clarification was needed. Candidate technologies were identified and characterized based on performance factors. Trade studies were then conducted for each subsystem. The resulting technologies were integrated into an overall design solution using mass flow relationships. The system level trade study yielded two different configurations--one for the transit to Mars and another for the surface habitat, which included in situ resource utilization. Equivalent System Mass analyses were used to compare each design against an open-loop (non-regenerable) baseline system. c2003 International Astronautical Federation. Published by Elsevier Ltd. All rights reserved.

Using multi-level Bayesian lesion-symptom mapping to probe the body-part-specificity of gesture imitation skills.

PubMed

Achilles, Elisabeth I S; Weiss, Peter H; Fink, Gereon R; Binder, Ellen; Price, Cathy J; Hope, Thomas M H

2017-11-01

Past attempts to identify the neural substrates of hand and finger imitation skills in the left hemisphere of the brain have yielded inconsistent results. Here, we analyse those associations in a large sample of 257 left hemisphere stroke patients. By introducing novel Bayesian methods, we characterise lesion symptom associations at three levels: the voxel-level, the single-region level (using anatomically defined regions), and the region-pair level. The results are inconsistent across those three levels and we argue that each level of analysis makes assumptions which constrain the results it can produce. Regardless of the inconsistencies across levels, and contrary to past studies which implicated differential neural substrates for hand and finger imitation, we find no consistent voxels or regions, where damage affects one imitation skill and not the other, at any of the three analysis levels. Our novel Bayesian approach indicates that any apparent differences appear to be driven by an increased sensitivity of hand imitation skills to lesions that also impair finger imitation. In our analyses, the results of the highest level of analysis (region-pairs) emphasise a role of the primary somatosensory and motor cortices, and the occipital lobe in imitation. We argue that this emphasis supports an account of both imitation tasks based on direct sensor-motor connections, which throws doubt on past accounts which imply the need for an intermediate (e.g. body-part-coding) system of representation. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

A Comparison of Social Dominance Theory and System Justification: The Role of Social Status in 19 Nations.

PubMed

Vargas-Salfate, Salvador; Paez, Dario; Liu, James H; Pratto, Felicia; Gil de Zúñiga, Homero

2018-07-01

This study tests specific competing hypotheses from social dominance theory/realistic conflict theory (RCT) versus system justification theory about the role of social status. In particular, it examines whether system justification belief and effects are stronger among people with low socioeconomic status, and in less socially developed and unequal nations than among better-off people and countries. A cross-national survey was carried out in 19 nations from the Americas, Western and Eastern Europe, Asia, and Oceania using representative online samples ( N = 14,936, 50.15% women, M age = 41.61 years). At the individual level, system justification beliefs, right-wing authoritarianism, social dominance orientation, national identification, sociopolitical conservatism, sex, age, and social status were measured. At the national level, the human development index and the Gini index were used. Multilevel analyses performed indicated that results fit better with the social dominance/RCT approach, as system justification was higher in high-status and developed nations; further, associations between legitimizing ideologies and system justification were stronger among high-status people.

Solar Power System Options for the Radiation and Technology Demonstration Spacecraft

NASA Technical Reports Server (NTRS)

Kerslake, Thomas W.; Haraburda, Francis M.; Riehl, John P.

2000-01-01

The Radiation and Technology Demonstration (RTD) Mission has the primary objective of demonstrating high-power (10 kilowatts) electric thruster technologies in Earth orbit. This paper discusses the conceptual design of the RTD spacecraft photovoltaic (PV) power system and mission performance analyses. These power system studies assessed multiple options for PV arrays, battery technologies and bus voltage levels. To quantify performance attributes of these power system options, a dedicated Fortran code was developed to predict power system performance and estimate system mass. The low-thrust mission trajectory was analyzed and important Earth orbital environments were modeled. Baseline power system design options are recommended on the basis of performance, mass and risk/complexity. Important findings from parametric studies are discussed and the resulting impacts to the spacecraft design and cost.

A customized resistivity system for monitoring saturation and seepage in earthen levees: installation and validation

NASA Astrophysics Data System (ADS)

Arosio, Diego; Munda, Stefano; Tresoldi, Greta; Papini, Monica; Longoni, Laura; Zanzi, Luigi

2017-10-01

This work is based on the assumption that a resistivity meter can effectively monitor water saturation in earth levees and can be used as a warning system when saturation exceeds the expected seasonal maxima. We performed time-lapse ERT measurements to assess the capability of this method to detect areas where seepage is critical. These measurements were also very useful to design a prototype monitoring system with remarkable savings by customizing the specifications according to field observations. The prototype consists of a remotely controlled low-power resistivity meter with a spread of 48 stainless steel 20 × 20 cm plate electrodes buried at half-meter depth. We deployed the newly-designed permanent monitoring system on a critical levee segment. A weather station and an ultrasonic water level sensor were also installed in order to analyse the correlation of resistivity with temperature, rainfalls and water level seasonal variations. The preliminary analysis of the monitoring data shows that the resistivity maps follow a very reasonable trend related with the saturation/drying cycle of the levee caused by the seasonal variations of the water level in the irrigation channel. Sharp water level changes cause delayed and smooth resistivity variations. Rainfalls and, to a lesser extent, temperature seem to have an influence on the collected data but effects are apparently negligible beyond 1 m depth. The system is currently operating and results are continuously monitored.

Design Methodology of an Equalizer for Unipolar Non Return to Zero Binary Signals in the Presence of Additive White Gaussian Noise Using a Time Delay Neural Network on a Field Programmable Gate Array

PubMed Central

Pérez Suárez, Santiago T.; Travieso González, Carlos M.; Alonso Hernández, Jesús B.

2013-01-01

This article presents a design methodology for designing an artificial neural network as an equalizer for a binary signal. Firstly, the system is modelled in floating point format using Matlab. Afterward, the design is described for a Field Programmable Gate Array (FPGA) using fixed point format. The FPGA design is based on the System Generator from Xilinx, which is a design tool over Simulink of Matlab. System Generator allows one to design in a fast and flexible way. It uses low level details of the circuits and the functionality of the system can be fully tested. System Generator can be used to check the architecture and to analyse the effect of the number of bits on the system performance. Finally the System Generator design is compiled for the Xilinx Integrated System Environment (ISE) and the system is described using a hardware description language. In ISE the circuits are managed with high level details and physical performances are obtained. In the Conclusions section, some modifications are proposed to improve the methodology and to ensure portability across FPGA manufacturers.

Including Recently Arrived English Learners in State Accountability Systems: An Empirical Illustration of Models. WCER Working Paper No. 2017-1

ERIC Educational Resources Information Center

Cook, H. Gary; Sahakyan, Narek; Linquanti, Robert

2017-01-01

The authors develop model analyses based on a U.S. Department of Education guide to illustrate procedures a State could use to compare and contrast school-level overall and English Learner accountability determinations for proficiency in reading/language arts under the options allowed by the Every Student Succeeds Act. As a technical reference,…

Open-Source Learning Management System and Web 2.0 Online Social Software Applications as Learning Platforms for an Elementary School in Singapore

ERIC Educational Resources Information Center

Tay, Lee Yong; Lim, Cher Ping; Lye, Sze Yee; Ng, Kay Joo; Lim, Siew Khiaw

2011-01-01

This paper analyses how an elementary-level future school in Singapore implements and uses various open-source online platforms, which are easily available online and could be implemented with minimal software cost, for the purpose of teaching and learning. Online platforms have the potential to facilitate students' engagement for independent and…

Where Have the Disruptions Gone? Educational Administration's Theoretical Capacity for Analysing or Fomenting Disruption

ERIC Educational Resources Information Center

Samier, Eugenie A.

2013-01-01

Within this essay and the author's reflections on the articles in this special issue, the question considered is: where have all the disruptions gone? On a fundamental level, educational leadership should have something to contribute, since it holds in trust the very educational systems that go a long way to producing the human condition, and…

Experiencing Spiritual Aspects Outdoors in the Winter: A Case Study from the Czech Republic Using the Method of Systemic Constellations

ERIC Educational Resources Information Center

Jirásek, Ivo; Jirásková, Miroslava; Majewská, Petra; Bolcková, Michaela

2017-01-01

The article focuses on spirituality on two semantic levels: the first one analyses participants' experiences during a winter expeditionary course on snowshoes and considers the question of whether residing in the winter landscape with a community of other people may acquire a spiritual dimension in spite of the non-religious environment. The…

An Analysis of the Content, Policies and Assessment of ICT Curricula in the Final Years of Secondary Schooling in Australia and Vietnam: A Comparative Educational Study

ERIC Educational Resources Information Center

Tran, Thang Manh; Stoilescu, Dorian

2016-01-01

This paper explores and analyses similarities and differences in ICT curricula, policies, and assessment between the Vietnamese and Australian educational systems for the final years of secondary educational level. It was found that while having a common core set of tendencies, the Australian ICT curricula, policies, and assessments differ…

System theory and safety models in Swedish, UK, Dutch and Australian road safety strategies.

PubMed

Hughes, B P; Anund, A; Falkmer, T

2015-01-01

Road safety strategies represent interventions on a complex social technical system level. An understanding of a theoretical basis and description is required for strategies to be structured and developed. Road safety strategies are described as systems, but have not been related to the theory, principles and basis by which systems have been developed and analysed. Recently, road safety strategies, which have been employed for many years in different countries, have moved to a 'vision zero', or 'safe system' style. The aim of this study was to analyse the successful Swedish, United Kingdom and Dutch road safety strategies against the older, and newer, Australian road safety strategies, with respect to their foundations in system theory and safety models. Analysis of the strategies against these foundations could indicate potential improvements. The content of four modern cases of road safety strategy was compared against each other, reviewed against scientific systems theory and reviewed against types of safety model. The strategies contained substantial similarities, but were different in terms of fundamental constructs and principles, with limited theoretical basis. The results indicate that the modern strategies do not include essential aspects of systems theory that describe relationships and interdependencies between key components. The description of these strategies as systems is therefore not well founded and deserves further development. Copyright © 2014 Elsevier Ltd. All rights reserved.

Study protocol for the translating research in elder care (TREC): building context – an organizational monitoring program in long-term care project (project one)

PubMed Central

Estabrooks, Carole A; Squires, Janet E; Cummings, Greta G; Teare, Gary F; Norton, Peter G

2009-01-01

Background While there is a growing awareness of the importance of organizational context (or the work environment/setting) to successful knowledge translation, and successful knowledge translation to better patient, provider (staff), and system outcomes, little empirical evidence supports these assumptions. Further, little is known about the factors that enhance knowledge translation and better outcomes in residential long-term care facilities, where care has been shown to be suboptimal. The project described in this protocol is one of the two main projects of the larger five-year Translating Research in Elder Care (TREC) program. Aims The purpose of this project is to establish the magnitude of the effect of organizational context on knowledge translation, and subsequently on resident, staff (unregulated, regulated, and managerial) and system outcomes in long-term care facilities in the three Canadian Prairie Provinces (Alberta, Saskatchewan, Manitoba). Methods/Design This study protocol describes the details of a multi-level – including provinces, regions, facilities, units within facilities, and individuals who receive care (residents) or work (staff) in facilities – and longitudinal (five-year) research project. A stratified random sample of 36 residential long-term care facilities (30 urban and 6 rural) from the Canadian Prairie Provinces will comprise the sample. Caregivers and care managers within these facilities will be asked to complete the TREC survey – a suite of survey instruments designed to assess organizational context and related factors hypothesized to be important to successful knowledge translation and to achieving better resident, staff, and system outcomes. Facility and unit level data will be collected using standardized data collection forms, and resident outcomes using the Resident Assessment Instrument-Minimum Data Set version 2.0 instrument. A variety of analytic techniques will be employed including descriptive analyses, psychometric analyses, multi-level modeling, and mixed-method analyses. Discussion Three key challenging areas associated with conducting this project are discussed: sampling, participant recruitment, and sample retention; survey administration (with unregulated caregivers); and the provision of a stable set of study definitions to guide the project. PMID:19671166

Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses.

PubMed

Vermeulen, Roel; Saberi Hosnijeh, Fatemeh; Bodinier, Barbara; Portengen, Lützen; Liquet, Benoît; Garrido-Manriquez, Javiera; Lokhorst, Henk; Bergdahl, Ingvar A; Kyrtopoulos, Soterios A; Johansson, Ann-Sofie; Georgiadis, Panagiotis; Melin, Beatrice; Palli, Domenico; Krogh, Vittorio; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Vineis, Paolo; Castagné, Raphaële; Chadeau-Hyam, Marc; Botsivali, Maria; Chatziioannou, Aristotelis; Valavanis, Ioannis; Kleinjans, Jos C S; de Kok, Theo M C M; Keun, Hector C; Athersuch, Toby J; Kelly, Rachel; Lenner, Per; Hallmans, Goran; Stephanou, Euripides G; Myridakis, Antonis; Kogevinas, Manolis; Fazzo, Lucia; De Santis, Marco; Comba, Pietro; Bendinelli, Benedetta; Kiviranta, Hannu; Rantakokko, Panu; Airaksinen, Riikka; Ruokojarvi, Paivi; Gilthorpe, Mark; Fleming, Sarah; Fleming, Thomas; Tu, Yu-Kang; Lundh, Thomas; Chien, Kuo-Liong; Chen, Wei J; Lee, Wen-Chung; Kate Hsiao, Chuhsing; Kuo, Po-Hsiu; Hung, Hung; Liao, Shu-Fen

2018-04-18

Recent prospective studies have shown that dysregulation of the immune system may precede the development of B-cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case-control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years before diagnosis (range 2.01-15.97) in 268 incident cases of BCL (including multiple myeloma [MM]) and matched controls. Linear mixed models and partial least square analyses were used to analyze the association between levels of immune marker and the incidence of BCL and its main histological subtypes and to investigate potential biomarkers predictive of the time to diagnosis. Linear mixed model analyses identified associations linking lower levels of fibroblast growth factor-2 (FGF-2 p = 7.2 × 10 -4 ) and transforming growth factor alpha (TGF-α, p = 6.5 × 10 -5 ) and BCL incidence. Analyses stratified by histological subtypes identified inverse associations for MM subtype including FGF-2 (p = 7.8 × 10 -7 ), TGF-α (p = 4.08 × 10 -5 ), fractalkine (p = 1.12 × 10 -3 ), monocyte chemotactic protein-3 (p = 1.36 × 10 -4 ), macrophage inflammatory protein 1-alpha (p = 4.6 × 10 -4 ) and vascular endothelial growth factor (p = 4.23 × 10 -5 ). Our results also provided marginal support for already reported associations between chemokines and diffuse large BCL (DLBCL) and cytokines and chronic lymphocytic leukemia (CLL). Case-only analyses showed that Granulocyte-macrophage colony stimulating factor levels were consistently higher closer to diagnosis, which provides further evidence of its role in tumor progression. In conclusion, our study suggests a role of growth-factors in the incidence of MM and of chemokine and cytokine regulation in DLBCL and CLL. © 2018 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

Thermal Structures Technology Development for Reusable Launch Vehicle Cryogenic Propellant Tanks

NASA Technical Reports Server (NTRS)

Johnson, Theodore F.; Natividad, Roderick; Rivers, H. Kevin; Smith, Russell

1998-01-01

Analytical and experimental studies conducted at the NASA Langley Research Center for investigating integrated cryogenic propellant tank systems for a Reusable Launch Vehicle are described. The cryogenic tanks are investigated as an integrated tank system. An integrated tank system includes the tank wall, cryogenic insulation, Thermal Protection System (TPS) attachment sub-structure, and TPS. Analysis codes are used to size the thicknesses of cryogenic insulation and TPS insulation for thermal loads, and to predict tank buckling strengths at various ring frame spacings. The unique test facilities developed for the testing of cryogenic tank components are described. Testing at cryogenic and high-temperatures verifies the integrity of materials, design concepts, manufacturing processes, and thermal/structural analyses. Test specimens ranging from the element level to the subcomponent level are subjected to projected vehicle operational mechanical loads and temperatures. The analytical and experimental studies described in this paper provide a portion of the basic information required for the development of light-weight reusable cryogenic propellant tanks.

Thermal Structures Technology Development for Reusable Launch Vehicle Cryogenic Propellant Tanks

NASA Technical Reports Server (NTRS)

Johnson, Theodore F.; Natividad, Roderick; Rivers, H. Kevin; Smith, Russell W.

2005-01-01

Analytical and experimental studies conducted at the NASA, Langley Research Center (LaRC) for investigating integrated cryogenic propellant tank systems for a reusable launch vehicle (RLV) are described. The cryogenic tanks are investigated as an integrated tank system. An integrated tank system includes the tank wall, cryogenic insulation, thermal protection system (TPS) attachment sub-structure, and TPS. Analysis codes are used to size the thicknesses of cryogenic insulation and TPS insulation for thermal loads, and to predict tank buckling strengths at various ring frame spacings. The unique test facilities developed for the testing of cryogenic tank components are described. Testing at cryogenic and high-temperatures verifies the integrity of materials, design concepts, manufacturing processes, and thermal/structural analyses. Test specimens ranging from the element level to the subcomponent level are subjected to projected vehicle operational mechanical loads and temperatures. The analytical and experimental studies described in this paper provide a portion of the basic information required for the development of light-weight reusable cryogenic propellant tanks.

High voltage interactions of a sounding rocket with the ambient and system-generated environments

NASA Technical Reports Server (NTRS)

Kuharski, Robert A.; Jongeward, Gary A.; Wilcox, Katherine G.; Rankin, Thomas V.; Roche, James C.

1990-01-01

EPSAT (environment power system analysis tool) is used to examine the design of SPEAR III, which is scheduled to fly in early 1991. It will test high-voltage designs in both ambient and system-generated environments. Two of the key questions that the experiment hopes to address are whether or not the earth's magnetic field can cause the current that a high-voltage object draws from the plasma to be far less than the current that would be drawn in the absence of the magnetic field and under what neutral environmental conditions a discharge from the high-voltage object to the plasma will occur. The EPSAT program makes it possible to perform a variety of analyses on a preliminary or conceptual-level description of a system in a short period of time. The calculations presented on SPEAR III are all done for a conceptual-level description. The calculations indicate that the experiment will produce the conditions necessary to address these questions.

Numerical Propulsion System Simulation Architecture

NASA Technical Reports Server (NTRS)

Naiman, Cynthia G.

2004-01-01

The Numerical Propulsion System Simulation (NPSS) is a framework for performing analysis of complex systems. Because the NPSS was developed using the object-oriented paradigm, the resulting architecture is an extensible and flexible framework that is currently being used by a diverse set of participants in government, academia, and the aerospace industry. NPSS is being used by over 15 different institutions to support rockets, hypersonics, power and propulsion, fuel cells, ground based power, and aerospace. Full system-level simulations as well as subsystems may be modeled using NPSS. The NPSS architecture enables the coupling of analyses at various levels of detail, which is called numerical zooming. The middleware used to enable zooming and distributed simulations is the Common Object Request Broker Architecture (CORBA). The NPSS Developer's Kit offers tools for the developer to generate CORBA-based components and wrap codes. The Developer's Kit enables distributed multi-fidelity and multi-discipline simulations, preserves proprietary and legacy codes, and facilitates addition of customized codes. The platforms supported are PC, Linux, HP, Sun, and SGI.

Revealing climate modes in steric sea levels: lessons learned from satellite geodesy, objective analyses and ocean reanalyses

NASA Astrophysics Data System (ADS)

Pfeffer, J.; Tregoning, P.; Purcell, A. P.

2017-12-01

Due to increased greenhouse gases emissions, the oceans are accumulating heat. In response to the ocean circulation and atmospheric forcing, the heat is irregularly redistributed within the oceans, causing sea level to rise at variable rates in space and time. These rates of steric expansion are extremely difficult to assess because of the sparsity of in-situ hydrographic observations available within the course of the 20th century. We compare here three methods to reconstruct the steric sea levels over the past 13, 25 and 58 years based on satellite geodesy, objective analyses and ocean reanalyses. The interannual to decadal variability of each dataset is explored with a model merging six climate indices representative of the natural variability of the ocean and climate system. Consistent regional patterns are identified for the Pacific Decadal Oscillation (PDO) and El Niño Southern Oscillation (ENSO) in all datasets at all timescales. Despite the short time coverage (13 years), the combination of satellite geodetic data (altimetry and GRACE) also reveals significant steric responses to the North Pacific Gyre Oscillation (NPGO), Indian Dipole (IOD) and Indian ocean basinwide (IOBM) mode. The richer information content in the ocean reanalyses allows us to recover the regional fingerprints of the PDO, ENSO, NPGO, IOD and IOBM, but also of the Atlantic Multidecadal Oscillation (AMO) acting over longer time scales (40 to 60 years). Therefore, ocean reanalyses, coupled with climate mode analyses, constitute innovative and promising tools to investigate the mechanisms triggering the variability of sea level rise over the past decades.

On-site Rapid Diagnosis of Intracranial Hematoma using Portable Multi-slice Microwave Imaging System.

PubMed

Mobashsher, Ahmed Toaha; Abbosh, A M

2016-11-29

Rapid, on-the-spot diagnostic and monitoring systems are vital for the survival of patients with intracranial hematoma, as their conditions drastically deteriorate with time. To address the limited accessibility, high costs and static structure of currently used MRI and CT scanners, a portable non-invasive multi-slice microwave imaging system is presented for accurate 3D localization of hematoma inside human head. This diagnostic system provides fast data acquisition and imaging compared to the existing systems by means of a compact array of low-profile, unidirectional antennas with wideband operation. The 3D printed low-cost and portable system can be installed in an ambulance for rapid on-site diagnosis by paramedics. In this paper, the multi-slice head imaging system's operating principle is numerically analysed and experimentally validated on realistic head phantoms. Quantitative analyses demonstrate that the multi-slice head imaging system is able to generate better quality reconstructed images providing 70% higher average signal to clutter ratio, 25% enhanced maximum signal to clutter ratio and with around 60% hematoma target localization compared to the previous head imaging systems. Nevertheless, numerical and experimental results demonstrate that previous reported 2D imaging systems are vulnerable to localization error, which is overcome in the presented multi-slice 3D imaging system. The non-ionizing system, which uses safe levels of very low microwave power, is also tested on human subjects. Results of realistic phantom and subjects demonstrate the feasibility of the system in future preclinical trials.

Structural Bioinformatics of the Interactome

PubMed Central

Petrey, Donald; Honig, Barry

2014-01-01

The last decade has seen a dramatic expansion in the number and range of techniques available to obtain genome-wide information, and to analyze this information so as to infer both the function of individual molecules and how they interact to modulate the behavior of biological systems. Here we review these techniques, focusing on the construction of physical protein-protein interaction networks, and highlighting approaches that incorporate protein structure which is becoming an increasingly important component of systems-level computational techniques. We also discuss how network analyses are being applied to enhance the basic understanding of biological systems and their disregulation, and how they are being applied in drug development. PMID:24895853

Fast hyper-spectral imaging of cytological samples in the mid-infrared wavelength region

NASA Astrophysics Data System (ADS)

Farries, Mark; Ward, Jon; Lindsay, Ian; Nallala, Jayakrupakar; Moselund, Peter

2017-02-01

A prototype mid-infrared spectral imaging system for rapid assessment of cells for cytological diagnosis is reported. Based on a fibre optic super-continuum source that has large spectral brightness and is coupled in to an acousto-optic tuneable filter that can rapidly scan over a set of wavelengths that are chosen to give a high level of selectivity for a specific skin disease. The system has the potential to collect an image cube of 100 wavelengths and 300k pixels in 2 seconds so that cells on living people could be analysed. The system has been evaluated with colon cells over 2700- 3100 cm-1.

Design of a two-level power system linear state estimator

NASA Astrophysics Data System (ADS)

Yang, Tao

The availability of synchro-phasor data has raised the possibility of a linear state estimator if the inputs are only complex currents and voltages and if there are enough such measurements to meet observability and redundancy requirements. Moreover, the new digital substations can perform some of the computation at the substation itself resulting in a more accurate two-level state estimator. The objective of this research is to develop a two-level linear state estimator processing synchro-phasor data and estimating the states at both the substation level and the control center level. Both the mathematical algorithms that are different from those in the present state estimation procedure and the layered architecture of databases, communications and application programs that are required to support this two-level linear state estimator are described in this dissertation. Besides, as the availability of phasor measurements at substations will increase gradually, this research also describes how the state estimator can be enhanced to handle both the traditional state estimator and the proposed linear state estimator simultaneously. This provides a way to immediately utilize the benefits in those parts of the system where such phasor measurements become available and provides a pathway to transition to the smart grid of the future. The design procedure of the two-level state estimator is applied to two study systems. The first study system is the IEEE-14 bus system. The second one is the 179 bus Western Electricity Coordinating Council (WECC) system. The static database for the substations is constructed from the power flow data of these systems and the real-time measurement database is produced by a power system dynamic simulating tool (TSAT). Time-skew problems that may be caused by communication delays are also considered and simulated. We used the Network Simulator (NS) tool to simulate a simple communication system and analyse its time delay performance. These time delays were too small to affect the results especially since the measurement data is time-stamped and the state estimator for these small systems could be run with subseconf frequency. Keywords: State Estimation, Synchro-Phasor Measurement, Distributed System, Energy Control Center, Substation, Time-skew

Fault tree analysis: NiH2 aerospace cells for LEO mission

NASA Technical Reports Server (NTRS)

Klein, Glenn C.; Rash, Donald E., Jr.

1992-01-01

The Fault Tree Analysis (FTA) is one of several reliability analyses or assessments applied to battery cells to be utilized in typical Electric Power Subsystems for spacecraft in low Earth orbit missions. FTA is generally the process of reviewing and analytically examining a system or equipment in such a way as to emphasize the lower level fault occurrences which directly or indirectly contribute to the major fault or top level event. This qualitative FTA addresses the potential of occurrence for five specific top level events: hydrogen leakage through either discrete leakage paths or through pressure vessel rupture; and four distinct modes of performance degradation - high charge voltage, suppressed discharge voltage, loss of capacity, and high pressure.

Measuring home advantage in Spanish handball.

PubMed

Gutiérrez Aguilar, Oscar; Saavedra García, Miguel; Fernández Romero, Juan José

2012-02-01

Since Pollard established the system for analysing home advantage in 1986, it has been demonstrated and quantified in various sports, including many team sports. This study aims to assess whether home advantage exists in handball, using a sample of more than 19,000 Spanish handball league games. Results of the games played at home and away, the sex of the players, and the levels of the competition were included as variables. In Spanish handball, there was a home advantage of 61%, which means, on average, the team playing at home wins 61% of points available. This value varies according to sex and according to competition level, increasing as competition level decreases and season rank improves.

Implementation of Local Wellness Policies in Schools: Role of School Systems, School Health Councils, and Health Disparities.

PubMed

Hager, Erin R; Rubio, Diana S; Eidel, G Stewart; Penniston, Erin S; Lopes, Megan; Saksvig, Brit I; Fox, Renee E; Black, Maureen M

2016-10-01

Written local wellness policies (LWPs) are mandated in school systems to enhance opportunities for healthy eating/activity. LWP effectiveness relies on school-level implementation. We examined factors associated with school-level LWP implementation. Hypothesized associations included system support for school-level implementation and having a school-level wellness team/school health council (SHC), with stronger associations among schools without disparity enrollment (majority African-American/Hispanic or low-income students). Online surveys were administered: 24 systems (support), 1349 schools (LWP implementation, perceived system support, SHC). The state provided school demographics. Analyses included multilevel multinomial logistic regression. Response rates were 100% (systems)/55.2% (schools). Among schools, 44.0% had SHCs, 22.6% majority (≥75%) African-American/Hispanic students, and 25.5% majority (≥75%) low-income (receiving free/reduced-price meals). LWP implementation (17-items) categorized as none = 36.3%, low (1-5 items) = 36.3%, high (6+ items) = 27.4%. In adjusted models, greater likelihood of LWP implementation was observed among schools with perceived system support (high versus none relative risk ratio, RRR = 1.63, CI: 1.49, 1.78; low versus none RRR = 1.26, CI: 1.18, 1.36) and SHCs (high versus none RRR = 6.8, CI: 4.07, 11.37; low versus none RRR = 2.24, CI: 1.48, 3.39). Disparity enrollment did not moderate associations (p > .05). Schools with perceived system support and SHCs had greater likelihood of LWP implementation, with no moderating effect of disparity enrollment. SHCs/support may overcome LWP implementation obstacles related to disparities. © 2016, American School Health Association.

An Approach to Risk-Based Design Incorporating Damage Tolerance Analyses

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Glaessgen, Edward H.; Sleight, David W.

2002-01-01

Incorporating risk-based design as an integral part of spacecraft development is becoming more and more common. Assessment of uncertainties associated with design parameters and environmental aspects such as loading provides increased knowledge of the design and its performance. Results of such studies can contribute to mitigating risk through a system-level assessment. Understanding the risk of an event occurring, the probability of its occurrence, and the consequences of its occurrence can lead to robust, reliable designs. This paper describes an approach to risk-based structural design incorporating damage-tolerance analysis. The application of this approach to a candidate Earth-entry vehicle is described. The emphasis of the paper is on describing an approach for establishing damage-tolerant structural response inputs to a system-level probabilistic risk assessment.

The ASSERT Virtual Machine Kernel: Support for Preservation of Temporal Properties

NASA Astrophysics Data System (ADS)

Zamorano, J.; de la Puente, J. A.; Pulido, J. A.; Urueña

2008-08-01

A new approach to building embedded real-time software has been developed in the ASSERT project. One of its key elements is the concept of a virtual machine preserving the non-functional properties of the system, and especially real-time properties, all the way down from high- level design models down to executable code. The paper describes one instance of the virtual machine concept that provides support for the preservation of temporal properties both at the source code level —by accept- ing only "legal" entities, i.e. software components with statically analysable real-tim behaviour— and at run-time —by monitoring the temporal behaviour of the system. The virtual machine has been validated on several pilot projects carried out by aerospace companies in the framework of the ASSERT project.

Nonlinear Optical Properties and Applications of Polydiacetylene

NASA Technical Reports Server (NTRS)

Abdeldayem, Hossin; Paley, Mark S.; Witherow, William K.; Frazier, Donald O.

2000-01-01

Recently, we have demonstrated a picosecond all-optical switch, which also functions as a partial all-optical NAND logic gate using a novel polydiacetylene that is synthesized in our laboratory. The nonlinear optical properties of the polydiacetylene material are measured using the Z-scan technique. A theoretical model based on a three level system is investigated and the rate equations of the system are solved. The theoretical calculations are proven to match nicely with the experimental results. The absorption cross-sections for both the first and higher excited states are estimated. The analyses also show that the material suffers a photochemical change beyond a certain level of the laser power and its physical properties suffer radical changes. These changes are the cause for the partial NAND gate function and the switching mechanism.

System-level modeling for geological storage of CO2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yingqi; Oldenburg, Curtis M.; Finsterle, Stefan

2006-04-24

One way to reduce the effects of anthropogenic greenhousegases on climate is to inject carbon dioxide (CO2) from industrialsources into deep geological formations such as brine formations ordepleted oil or gas reservoirs. Research has and is being conducted toimprove understanding of factors affecting particular aspects ofgeological CO2 storage, such as performance, capacity, and health, safetyand environmental (HSE) issues, as well as to lower the cost of CO2capture and related processes. However, there has been less emphasis todate on system-level analyses of geological CO2 storage that considergeological, economic, and environmental issues by linking detailedrepresentations of engineering components and associated economic models.Themore » objective of this study is to develop a system-level model forgeological CO2 storage, including CO2 capture and separation,compression, pipeline transportation to the storage site, and CO2injection. Within our system model we are incorporating detailedreservoir simulations of CO2 injection and potential leakage withassociated HSE effects. The platform of the system-level modelingisGoldSim [GoldSim, 2006]. The application of the system model is focusedon evaluating the feasibility of carbon sequestration with enhanced gasrecovery (CSEGR) in the Rio Vista region of California. The reservoirsimulations are performed using a special module of the TOUGH2 simulator,EOS7C, for multicomponent gas mixtures of methane and CO2 or methane andnitrogen. Using this approach, the economic benefits of enhanced gasrecovery can be directly weighed against the costs, risks, and benefitsof CO2 injection.« less

Good governance and corruption in the health sector: lessons from the Karnataka experience.

PubMed

Huss, R; Green, A; Sudarshan, H; Karpagam, Ss; Ramani, Kv; Tomson, G; Gerein, N

2011-11-01

Strengthening good governance and preventing corruption in health care are universal challenges. The Karnataka Lokayukta (KLA), a public complaints agency in Karnataka state (India), was created in 1986 but played a prominent role controlling systemic corruption only after a change of leadership in 2001 with a new Lokayukta (ombudsman) and Vigilance Director for Health (VDH). This case study of the KLA (2001-06) analysed the:Scope and level of poor governance in the health sector; KLA objectives and its strategy; Factors which affected public health sector governance and the operation of the KLA. We used a participatory and opportunistic evaluation design, examined documents about KLA activities, conducted three site visits, two key informant and 44 semi-structured interviews and used a force field model to analyse the governance findings. The Lokayukta and his VDH were both proactive and economically independent with an extended social network, technical expertise in both jurisdiction and health care, and were widely perceived to be acting for the common good. They mobilized media and the public about governance issues which were affected by factors at the individual, organizational and societal levels. Their investigations revealed systemic corruption within the public health sector at all levels as well as in public/private collaborations and the political and justice systems. However, wider contextual issues limited their effectiveness in intervening. The departure of the Lokayukta, upon completing his term, was due to a lack of continued political support for controlling corruption. Governance in the health sector is affected by positive and negative forces. A key positive factor was the combined social, cultural and symbolic capital of the two leaders which empowered them to challenge corrupt behaviour and promote good governance. Although change was possible, it was precarious and requires continuous political support to be sustained.

Effects of El Niño-Southern Oscillation on sea level anomalies along the Gulf of Mexico coast

NASA Astrophysics Data System (ADS)

Kennedy, Andrew J.; Griffin, Melissa L.; Morey, Steven L.; Smith, Shawn R.; O'Brien, James J.

2007-05-01

Analyses of daily sea level data show the impacts of El Niño-Southern Oscillation (ENSO) in the Gulf of Mexico (GOM). Data from three stations (St. Petersburg, Florida, Pensacola, Florida, and Galveston, Texas), all of which have at least 50 years of daily observations, are processed to identify the interannual signals. Although low frequency (interannual) signals in the sea level anomaly time series are not clearly evident, a low frequency modulation of the extreme anomaly events (upper 10% or lower 10% of the distributions) is identified. Results show that sea level variability is seasonally dependent at all stations, with maximum variability in the winter months. In the eastern GOM, low sea level events in the winter months are more frequent during El Niño (warm phase) conditions when compared to a neutral ENSO phase. This is consistent with ENSO-related changes in the location where extratropical atmospheric low pressure systems form and in the tracks of these weather systems. The impacts of tropical systems in the summer through early fall months on coastal sea level in the GOM are shown by infrequent extreme high and low anomalies coinciding with individual storms. However, the number of storms affecting the data record from a particular sea level station is too small to confirm ENSO-related variability. Statistical methods are employed to demonstrate a significant link between extreme sea level anomalies in the GOM and ENSO during the October to March period.

Access to medicines from a health system perspective

PubMed Central

Bigdeli, Maryam; Jacobs, Bart; Tomson, Goran; Laing, Richard; Ghaffar, Abdul; Dujardin, Bruno; Van Damme, Wim

2013-01-01

Most health system strengthening interventions ignore interconnections between systems components. In particular, complex relationships between medicines and health financing, human resources, health information and service delivery are not given sufficient consideration. As a consequence, populations' access to medicines (ATM) is addressed mainly through fragmented, often vertical approaches usually focusing on supply, unrelated to the wider issue of access to health services and interventions. The objective of this article is to embed ATM in a health system perspective. For this purpose, we perform a structured literature review: we examine existing ATM frameworks, review determinants of ATM and define at which level of the health system they are likely to occur; we analyse to which extent existing ATM frameworks take into account access constraints at different levels of the health system. Our findings suggest that ATM barriers are complex and interconnected as they occur at multiple levels of the health system. Existing ATM frameworks only partially address the full range of ATM barriers. We propose three essential paradigm shifts that take into account complex and dynamic relationships between medicines and other components of the health system. A holistic view of demand-side constraints in tandem with consideration of multiple and dynamic relationships between medicines and other health system resources should be applied; it should be recognized that determinants of ATM are rooted in national, regional and international contexts. These are schematized in a new framework proposing a health system perspective on ATM. PMID:23174879

[Effects of extremely high-frequency electromagnetic radiation on the immune system and systemic regulation of homeostasis].

PubMed

Lushnikov, K V; Gapeev, A B; Chemeris, N K

2002-01-01

Low-intensity of electromagnetic radiation of extremely high frequencies (EHF EMR) is effectively used in medical practice for diagnostics, prevention and treatment of a broad spectrum of diseases of different etiology. However, in spite of existence of many hypotheses about mechanisms of EHF EMR effects on the molecular and cellular levels of organization of living systems, there is not conception that could explain all diversity of the EHF-therapy effects from unified approach. In our opinion, the problem of determination of mechanisms of EHF EMR effects on living organism is divided into two basic tasks: first, determining subcellular structures which can receive radiation, and, second, studying physiological reactions of the organism which are caused by radiation. It is obviously, that investigation of functions of single cells and subcellular elements can not entirely explain therapeutic effects and mechanisms of EHF EMR influence on multicellular organism on the whole. Plenty of functional relationships between organs and systems of organs should be taken into account. In the present review, a realization of the EHF-therapy effects due to the influence on immune system functions and start of system mechanisms of maintenance of the homeostasis on the organism level is hypothesized. Potential targets for EHF EMR acception on the level of different systems of the organism are analysed. The material is formed so that functional relations between immune system and other regulatory systems (nervous and endocrine systems) are traced.

Scaling of Ion Thrusters to Low Power

NASA Technical Reports Server (NTRS)

Patterson, Michael J.; Grisnik, Stanley P.; Soulas, George C.

1998-01-01

Analyses were conducted to examine ion thruster scaling relationships in detail to determine performance limits, and lifetime expectations for thruster input power levels below 0.5 kW. This was motivated by mission analyses indicating the potential advantages of high performance, high specific impulse systems for small spacecraft. The design and development status of a 0.1-0.3 kW prototype small thruster and its components are discussed. Performance goals include thruster efficiencies on the order of 40% to 54% over a specific impulse range of 2000 to 3000 seconds, with a lifetime in excess of 8000 hours at full power. Thruster technologies required to achieve the performance and lifetime targets are identified.

A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma.

PubMed

Cham, Gerald K K; Kurtis, Jonathan; Lusingu, John; Theander, Thor G; Jensen, Anja T R; Turner, Louise

2008-06-12

The level of antibodies against PfEMP1 is routinely quantified by the conventional microtitre enzyme-linked immunosorbent assay (ELISA). However, ELISA only measures one analyte at a time and requires a relatively large plasma volume if the complete antibody profile of the sample is to be obtained. Furthermore, assay-to-assay variation and the problem of storage of antigen can influence ELISA results. The bead-based assay described here uses the BioPlex100 (BioRad, Hercules, CA, USA) system which can quantify multiple antibodies simultaneously in a small plasma volume. A total of twenty nine PfEMP1 domains were PCR amplified from 3D7 genomic DNA, expressed in the Baculovirus system and purified by metal-affinity chromatography. The antibody reactivity level to the recombinant PfEMP1 proteins in human hyper-immune plasma was measured by ELISA. In parallel, these recombinant PfEMP1 proteins were covalently coupled onto beads each having its own unique detection signal and the human hyper-immune plasma reactivity was detected for each individual protein using a BioPlex100 system. Protein-coupled beads were analysed at two time points seven months apart, before and after lyophilization and the results compared to determine the effect of storage and lyophilization respectively on the beads. Multiplexed protein-coupled beads from twenty eight unique bead populations were evaluated on the BioPlex100 system against pooled human hyper-immune plasma before and after lyophilization. The bead-based assay was sensitive, accurate and reproducible. Four recombinant PfEMP1 proteins C17, D5, D9 and D12, selected on the basis that they showed a spread of median fluorescent intensity (MFI) values from low to high when analysed by the bead-based assay were analysed by ELISA and the results from both analyses were highly correlated. The Spearman's rank correlation coefficients (Rho) were > or = 0.86, (P < 0.0001) for all comparisons. Bead-based assays gave similar results regardless of whether they were performed on individual beads or on multiplexed beads; lyophilization had no impact on the assay performance. Spearman's rank correlation coefficients (Rho) were > or = 0.97, (P < 0.0001) for all comparisons. Importantly, the reactivity of protein-coupled non-lyophilized beads decreased with long term storage at 4 degrees C in the dark. Using this lyophilized multiplex assay, antibody reactivity levels to twenty eight different recombinant PfEMP1 proteins were simultaneously measured using a single microliter of plasma. Thus, the assay reported here provides a useful tool for rapid and efficient quantification of antibody reactivity against PfEMP1 variants in human plasma.

Mapping healthcare systems: a policy relevant analytic tool

PubMed Central

Sekhri Feachem, Neelam; Afshar, Ariana; Pruett, Cristina; Avanceña, Anton L.V.

2017-01-01

Abstract Background In the past decade, an international consensus on the value of well-functioning systems has driven considerable health systems research. This research falls into two broad categories. The first provides conceptual frameworks that take complex healthcare systems and create simplified constructs of interactions and functions. The second focuses on granular inputs and outputs. This paper presents a novel translational mapping tool – the University of California, San Francisco mapping tool (the Tool) - which bridges the gap between these two areas of research, creating a platform for multi-country comparative analysis. Methods Using the Murray-Frenk framework, we create a macro-level representation of a country's structure, focusing on how it finances and delivers healthcare. The map visually depicts the fundamental policy questions in healthcare system design: funding sources and amount spent through each source, purchasers, populations covered, provider categories; and the relationship between these entities. Results We use the Tool to provide a macro-level comparative analysis of the structure of India's and Thailand's healthcare systems. Conclusions As part of the systems strengthening arsenal, the Tool can stimulate debate about the merits and consequences of different healthcare systems structural designs, using a common framework that fosters multi-country comparative analyses. PMID:28541518

Fuzzy robust credibility-constrained programming for environmental management and planning.

PubMed

Zhang, Yimei; Hang, Guohe

2010-06-01

In this study, a fuzzy robust credibility-constrained programming (FRCCP) is developed and applied to the planning for waste management systems. It incorporates the concepts of credibility-based chance-constrained programming and robust programming within an optimization framework. The developed method can reflect uncertainties presented as possibility-density by fuzzy-membership functions. Fuzzy credibility constraints are transformed to the crisp equivalents with different credibility levels, and ordinary fuzzy inclusion constraints are determined by their robust deterministic constraints by setting a-cut levels. The FRCCP method can provide different system costs under different credibility levels (lambda). From the results of sensitivity analyses, the operation cost of the landfill is a critical parameter. For the management, any factors that would induce cost fluctuation during landfilling operation would deserve serious observation and analysis. By FRCCP, useful solutions can be obtained to provide decision-making support for long-term planning of solid waste management systems. It could be further enhanced through incorporating methods of inexact analysis into its framework. It can also be applied to other environmental management problems.

Aerospace engineering design by systematic decomposition and multilevel optimization

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, J.; Giles, G. L.; Barthelemy, J.-F. M.

1984-01-01

This paper describes a method for systematic analysis and optimization of large engineering systems, e.g., aircraft, by decomposition of a large task into a set of smaller, self-contained subtasks that can be solved concurrently. The subtasks may be arranged in many hierarchical levels with the assembled system at the top level. Analyses are carried out in each subtask using inputs received from other subtasks, and are followed by optimizations carried out from the bottom up. Each optimization at the lower levels is augmented by analysis of its sensitivity to the inputs received from other subtasks to account for the couplings among the subtasks in a formal manner. The analysis and optimization operations alternate iteratively until they converge to a system design whose performance is maximized with all constraints satisfied. The method, which is still under development, is tentatively validated by test cases in structural applications and an aircraft configuration optimization. It is pointed out that the method is intended to be compatible with the typical engineering organization and the modern technology of distributed computing.

[Immigrant perceptions of the Spanish National Healthcare System and its services].

PubMed

Velasco, César; Vinasco, Ana Maria; Trilla, Antoni

2016-03-01

To analyse the perception, use and satisfaction of a group of immigrants living in Barcelona taking into account their gender, origin and social class. Cross sectional study. City of Barcelona, Spain. A group of 225 immigrant residents and users of social services in the city of Barcelona, from June to July 2012. the level of access and relationship with the public health system of immigrants living in Barcelona was analysed, based on a questionnaire. The responses were analysed in relation to: gender, age, social class, self-perceived health, national origin, time since arrival, and marital status. The large majority (89%) of the population surveyed declared that the most important aspect was «to have been treated with respect» in health services. However, 59.4% reported a perception of «discrimination against immigrants», and 68.4% said that cultural differences affect «totally or partially» the quality of care received. For 66.7% of the participants, health care received in Barcelona is better than in their home country, mainly for its scientific, technical quality, and universal access. Despite the good assessment of universal public health care system this study showed deficiencies of the system in terms of the psychosocial component of health care to immigrants in Barcelona. It is necessary to deepen the study of knowledge and perceptions of minority groups in the current context. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

Requirements Engineering for inter-organizational health information systems with functions for spatial analyses: modeling a WHO safe community applying Use Case Maps.

PubMed

Olvingson, C; Hallberg, N; Timpka, T; Lindqvist, K

2002-01-01

To evaluate Use Case Maps (UCMs) as a technique for Requirements Engineering (RE) in the development of information systems with functions for spatial analyses in inter-organizational public health settings. In this study, Participatory Action Research (PAR) is used to explore the UCM notation for requirements elicitation and to gather the opinions of the users. The Delphi technique is used to reach consensus in the construction of UCMs. The results show that UCMs can provide a visualization of the system's functionality and in combination with PAR provide a sound basis for gathering requirements in inter-organizational settings. UCMs were found to represent a suitable level for describing the organization and the dynamic flux of information including spatial resolution to all stakeholders. Moreover, by using PAR, the voices of the users and their tacit knowledge is intercepted. Further, UCMs are found useful in generating intuitive requirements by the creation of use cases. With UCMs and PAR it is possible to study the effects of design changes in the general information display and the spatial resolution in the same context. Both requirements on the information system in general and the functions for spatial analyses are possible to elicit when identifying the different responsibilities and the demands on spatial resolution associated to the actions of each administrative unit. However, the development process of UCM is not well documented and needs further investigation and formulation of guidelines.

Diesel exhaust and lung cancer in the trucking industry: exposure-response analyses and risk assessment.

PubMed

Steenland, K; Deddens, J; Stayner, L

1998-09-01

Diesel exhaust is considered a probable human carcinogen by the International Agency for Research on Cancer (IARC). The epidemiologic evidence rests on studies of lung cancer among truck drivers, bus drivers, shipyard workers, and railroad workers. The general public is exposed to diesel exhaust in ambient air. Two regulatory agencies are now considering regulating levels of diesel exhaust: the California EPA (ambient levels) and the Mine Safety Health Administration (MSHA) (occupational levels). To date, there have been few quantitative exposure-response analyses of diesel and lung cancer based on human data. We conducted exposure-response analyses among workers in the trucking industry, adjusted for smoking. Diesel exhaust exposure was estimated based on a 1990 industrial hygiene survey. Past exposures were estimated assuming that they were a function of 1) the number of heavy duty trucks on the road, 2) the particulate emissions (grams/mile) of diesel engines over time, and 3) leaks from trucks' exhaust systems for long-haul drivers. Regardless of assumptions about past exposure, all analyses resulted in significant positive trends in lung cancer risk with increasing cumulative exposure. A male truck driver exposed to 5 micrograms/m3 of elemental carbon (a typical exposure in 1990, approximately five times urban background levels) would have a lifetime excess risk of lung cancer of 1-2% above a background risk of 5%. We found a lifetime excess risk ten times higher than the 1 per 1,000 excess risk allowed by OSHA in setting regulations. There are about 2.8 million truck drivers in the U.S. Our results depend on estimates about unknown past exposures, and should be viewed as exploratory. They conform reasonably well to recent estimates for diesel-exposed railroad workers done by the California EPA, although those results themselves have been disputed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tamanini, Nicola; Wright, Matthew, E-mail: nicola.tamanini@cea.fr, E-mail: matthew.wright.13@ucl.ac.uk

We investigate the cosmological dynamics of the recently proposed extended chameleon models at both background and linear perturbation levels. Dynamical systems techniques are employed to fully characterize the evolution of the universe at the largest distances, while structure formation is analysed at sub-horizon scales within the quasi-static approximation. The late time dynamical transition from dark matter to dark energy domination can be well described by almost all extended chameleon models considered, with no deviations from ΛCDM results at both background and perturbation levels. The results obtained in this work confirm the cosmological viability of extended chameleons as alternative dark energymore » models.« less

Propulsion integration of hypersonic air-breathing vehicles utilizing a top-down design methodology

NASA Astrophysics Data System (ADS)

Kirkpatrick, Brad Kenneth

In recent years, a focus of aerospace engineering design has been the development of advanced design methodologies and frameworks to account for increasingly complex and integrated vehicles. Techniques such as parametric modeling, global vehicle analyses, and interdisciplinary data sharing have been employed in an attempt to improve the design process. The purpose of this study is to introduce a new approach to integrated vehicle design known as the top-down design methodology. In the top-down design methodology, the main idea is to relate design changes on the vehicle system and sub-system level to a set of over-arching performance and customer requirements. Rather than focusing on the performance of an individual system, the system is analyzed in terms of the net effect it has on the overall vehicle and other vehicle systems. This detailed level of analysis can only be accomplished through the use of high fidelity computational tools such as Computational Fluid Dynamics (CFD) or Finite Element Analysis (FEA). The utility of the top-down design methodology is investigated through its application to the conceptual and preliminary design of a long-range hypersonic air-breathing vehicle for a hypothetical next generation hypersonic vehicle (NHRV) program. System-level design is demonstrated through the development of the nozzle section of the propulsion system. From this demonstration of the methodology, conclusions are made about the benefits, drawbacks, and cost of using the methodology.

How can the use of data within the immunisation programme be increased in order to improve data quality and ensure greater accountability in the health system? A protocol for implementation science study.

PubMed

Tilahun, Binyam; Teklu, Alemayehu; Mancuso, Arielle; Abebaw, Zeleke; Dessie, Kassahun; Zegeye, Desalegn

2018-05-03

Immunisation remains one of the most important and cost-effective interventions to reduce vaccine-preventable child morbidity, disability and mortality. Health programmes like the Expanded Program of Immunization rely on complex decision-making and strong local level evidence is important to effectively and efficiently utilise limited resources. Lack of data use for decision-making at each level of the health system remains the main challenge in most developing countries. While there is much evidence on data quality and how to improve it, there is a lack of sufficient evidence on why the use of data for decision-making at each level of the health system is low. Herein, we describe a comprehensive implementation science study that will be conducted to identify organisational, technical and individual level factors affecting local data use at each level of the Ethiopian health system. We will apply a mixed methods approach using key informant interviews and document reviews. The qualitative data will be gathered through key informant interviews using a semi-structured guide with open- and closed-ended questions with four categories of respondents, namely decision-makers, data producers, data users and community representatives at the federal, regional, zonal, woreda and community levels of the health system. The document review will be conducted on selected reports and feedback documented at different levels of the health system. Data will be collected from July 2017 to March 2018. Descriptive statistics will be analysed for the quantitative study using SPSS version 20 software and thematic content analysis will be performed for the qualitative part using NVivo software. Appropriate and timely use of health and health-related information for decision-making is an essential element in the process of transforming the health sector. The findings of the study will inform stakeholders at different levels on the institutionalisation of evidence-based practice in immunisation programmes.

Impact of Capital and Current Costs Changes of the Incineration Process of the Medical Waste on System Management Cost

NASA Astrophysics Data System (ADS)

Jolanta Walery, Maria

2017-12-01

The article describes optimization studies aimed at analysing the impact of capital and current costs changes of medical waste incineration on the cost of the system management and its structure. The study was conducted on the example of an analysis of the system of medical waste management in the Podlaskie Province, in north-eastern Poland. The scope of operational research carried out under the optimization study was divided into two stages of optimization calculations with assumed technical and economic parameters of the system. In the first stage, the lowest cost of functioning of the analysed system was generated, whereas in the second one the influence of the input parameter of the system, i.e. capital and current costs of medical waste incineration on economic efficiency index (E) and the spatial structure of the system was determined. Optimization studies were conducted for the following cases: with a 25% increase in capital and current costs of incineration process, followed by 50%, 75% and 100% increase. As a result of the calculations, the highest cost of system operation was achieved at the level of 3143.70 PLN/t with the assumption of 100% increase in capital and current costs of incineration process. There was an increase in the economic efficiency index (E) by about 97% in relation to run 1.

Cognitive context detection in UAS operators using eye-gaze patterns on computer screens

NASA Astrophysics Data System (ADS)

Mannaru, Pujitha; Balasingam, Balakumar; Pattipati, Krishna; Sibley, Ciara; Coyne, Joseph

2016-05-01

In this paper, we demonstrate the use of eye-gaze metrics of unmanned aerial systems (UAS) operators as effective indices of their cognitive workload. Our analyses are based on an experiment where twenty participants performed pre-scripted UAS missions of three different difficulty levels by interacting with two custom designed graphical user interfaces (GUIs) that are displayed side by side. First, we compute several eye-gaze metrics, traditional eye movement metrics as well as newly proposed ones, and analyze their effectiveness as cognitive classifiers. Most of the eye-gaze metrics are computed by dividing the computer screen into "cells". Then, we perform several analyses in order to select metrics for effective cognitive context classification related to our specific application; the objective of these analyses are to (i) identify appropriate ways to divide the screen into cells; (ii) select appropriate metrics for training and classification of cognitive features; and (iii) identify a suitable classification method.

The prevalence of deoxynivalenol and its derivatives in the spring wheat grain from different agricultural production systems in Lithuania.

PubMed

Janaviciene, Sigita; Mankeviciene, Audrone; Suproniene, Skaidre; Kochiieru, Yuliia; Keriene, Ilona

2018-02-22

Deoxynivalenol (DON) together with two acetylated derivatives, 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-ADON) occurs in cereal grains and their products. Co-occurrence of DON and acetylated derivatives in cereal grain is detected worldwide. Until now, DON and its derivatives have been considered equally toxic by health authorities. In this study, we analysed 103 samples of spring wheat grain, originating from the fields of different production systems in Lithuania, for the co-occurrence of type-B trichothecenes (DON, 3-ADON, 15-ADON). The samples were classified according to the production system-organic, sustainable and intensive. Mycotoxin levels in the spring wheat grain samples were determined by the HPLC method with UV detection. The type-B trichothecenes were found to be present at higher concentrations in the grain from the intensive production system. Eighty-one percent of the spring wheat grain samples from the intensive production system were co-contaminated with a combination of DON+3-ADON+15-ADON, 1% with DON+3-ADON. Additionally, DON+15-ADON and DON were found in 5% and 10% of the tested samples, respectively. Two percent of the samples were free from mycotoxins. In the grain samples from the sustainable production system, DON and a combination of DON+3-ADON showed a higher incidence - 47% and 23%, respectively. The samples with a combination of DON+3-ADON+15-ADON accounted for 18%. Completely different results were obtained from the analyses of organic grain samples. A large number of the organic spring wheat grain samples were contaminated with DON+3-ADON (55%) or DON (36%). The combination of DON+3-ADON+15-ADON was not present, while DON+15-ADON was present in 9% of the samples tested. The production systems did not lead to significant differences in mycotoxin levels, although a trend toward higher incidence and higher contamination was observed for the samples from the intensive and sustainable production systems.

The effect of additional brain injury on systemic interleukin (IL)-10 and IL-13 levels in trauma patients.

PubMed

Hensler, T; Sauerland, S; Riess, P; Hess, S; Helling, H J; Andermahr, J; Bouillon, B; Neugebauer, E A

2000-10-01

Besides interleukin (IL)-10, accumulating evidence from in vitro studies has indicated a strong antiinflammatory capacity for IL-13. A prospective clinical study was undertaken to assess the influence of additional brain injury on systemic IL-10 and IL-13 levels as markers for the antiinflammatory state in trauma patients. The course of IL-10 and IL-13 plasma levels from 32 patients with an isolated severe head trauma (SHT), 50 patients with multiple injuries and additional SHT and 39 patients with multiple injuries without SHT was detected using ELISA-technique. Blood samples from 37 healthy blood donors were analysed for control. IL-10 levels were significantly elevated in all 3 injury groups within 3 h after trauma. The lowest initial release was detected in patients with an isolated SHT (Injury severity score; ISS: 18.1 +/- 5.6). No difference could be demonstrated for the IL-10 levels from multiple injured patients with (ISS: 35.3 +/- 9.6) or without additional SHT (ISS: 25.5 +/- 11.7), though there were relevant differences in the ISS. In contrast, the IL-13 plasma levels were not elevated systemically after trauma. IL-10 but not IL-13 is a detectable antiinflammatory marker in trauma patients with or without brain injury and to a minor degree in patients with an isolated SHT.

Effect of algorithm aggressiveness on the performance of the Hypoglycemia-Hyperglycemia Minimizer (HHM) System.

PubMed

Finan, Daniel A; McCann, Thomas W; Rhein, Kathleen; Dassau, Eyal; Breton, Marc D; Patek, Stephen D; Anhalt, Henry; Kovatchev, Boris P; Doyle, Francis J; Anderson, Stacey M; Zisser, Howard; Venugopalan, Ramakrishna

2014-07-01

The Hypoglycemia-Hyperglycemia Minimizer (HHM) System aims to mitigate glucose excursions by preemptively modulating insulin delivery based on continuous glucose monitor (CGM) measurements. The "aggressiveness factor" is a key parameter in the HHM System algorithm, affecting how readily the system adjusts insulin infusion in response to changing CGM levels. Twenty adults with type 1 diabetes were studied in closed-loop in a clinical research center for approximately 26 hours. This analysis focused on the effect of the aggressiveness factor on the insulin dosing characteristics of the algorithm and, to a lesser extent, on the glucose control results observed. As the aggressiveness factor increased from conservative to medium to aggressive: the maximum observed insulin dose delivered by the algorithm—which is designed to give doses that are corrective in nature every 5 minutes—increased (1.00 vs 1.15 vs 2.20 U, respectively); tendency to adhere to the subject's nominal basal dose decreased (61.9% vs 56.6% vs 53.4%); and readiness to decrease insulin below basal also increased (18.4% vs 19.4% vs 25.2%). Glucose analyses by both CGM and Yellow Springs Instruments (YSI) indicated that the aggressive setting of the algorithm resulted in the least time spent at levels >180 mg/dL, and the most time spent between 70-180 mg/dL. There was no severe hyperglycemia, diabetic ketoacidosis, or severe hypoglycemia for any of the aggressiveness values investigated. These analyses underscore the importance of investigating the sensitivity of the HHM System to its key parameters, such as the aggressiveness factor, to guide future development decisions. © 2014 Diabetes Technology Society.

Collateral transgression of planetary boundaries due to climate engineering by terrestrial carbon dioxide removal

NASA Astrophysics Data System (ADS)

Heck, Vera; Donges, Jonathan F.; Lucht, Wolfgang

2016-10-01

The planetary boundaries framework provides guidelines for defining thresholds in environmental variables. Their transgression is likely to result in a shift in Earth system functioning away from the relatively stable Holocene state. As the climate system is approaching critical thresholds of atmospheric carbon, several climate engineering methods are discussed, aiming at a reduction of atmospheric carbon concentrations to control the Earth's energy balance. Terrestrial carbon dioxide removal (tCDR) via afforestation or bioenergy production with carbon capture and storage are part of most climate change mitigation scenarios that limit global warming to less than 2 °C. We analyse the co-evolutionary interaction of societal interventions via tCDR and the natural dynamics of the Earth's carbon cycle. Applying a conceptual modelling framework, we analyse how the degree of anticipation of the climate problem and the intensity of tCDR efforts with the aim of staying within a "safe" level of global warming might influence the state of the Earth system with respect to other carbon-related planetary boundaries. Within the scope of our approach, we show that societal management of atmospheric carbon via tCDR can lead to a collateral transgression of the planetary boundary of land system change. Our analysis indicates that the opportunities to remain in a desirable region within carbon-related planetary boundaries only exist for a small range of anticipation levels and depend critically on the underlying emission pathway. While tCDR has the potential to ensure the Earth system's persistence within a carbon-safe operating space under low-emission pathways, it is unlikely to succeed in a business-as-usual scenario.

Pluvial, urban flood mechanisms and characteristics - Assessment based on insurance claims

NASA Astrophysics Data System (ADS)

Sörensen, Johanna; Mobini, Shifteh

2017-12-01

Pluvial flooding is a problem in many cities and for city planning purpose the mechanisms behind pluvial flooding are of interest. Previous studies seldom use insurance claim data to analyse city scale characteristics that lead to flooding. In the present study, two long time series (∼20 years) of flood claims from property owners have been collected and analysed in detail to investigate the mechanisms and characteristics leading to urban flooding. The flood claim data come from the municipal water utility company and property owners with insurance that covers property loss from overland flooding, groundwater intrusion through basement walls and flooding from the drainage system. These data are used as a proxy for flood severity for several events in the Swedish city of Malmö. It is discussed which rainfall characteristics give most flooding and why some rainfall events do not lead to severe flooding, how city scale topography and sewerage system type influence spatial distribution of flood claims, and which impact high sea level has on flooding in Malmö. Three severe flood events are described in detail and compared with a number of smaller flood events. It was found that the main mechanisms and characteristics of flood extent and its spatial distribution in Malmö are intensity and spatial distribution of rainfall, distance to the main sewer system as well as overland flow paths, and type of drainage system, while high sea level has little impact on the flood extent. Finally, measures that could be taken to lower the flood risk in Malmö, and other cities with similar characteristics, are discussed.

Inferring a dual-stream model of mentalizing from associative white matter fibres disconnection.

PubMed

Herbet, Guillaume; Lafargue, Gilles; Bonnetblanc, François; Moritz-Gasser, Sylvie; Menjot de Champfleur, Nicolas; Duffau, Hugues

2014-03-01

In the field of cognitive neuroscience, it is increasingly accepted that mentalizing is subserved by a complex frontotemporoparietal cortical network. Some researchers consider that this network can be divided into two distinct but interacting subsystems (the mirror system and the mentalizing system per se), which respectively process low-level, perceptive-based aspects and high-level, inference-based aspects of this sociocognitive function. However, evidence for this type of functional dissociation in a given neuropsychological population is currently lacking and the structural connectivities of the two mentalizing subnetworks have not been established. Here, we studied mentalizing in a large sample of patients (n = 93; 46 females; age range: 18-65 years) who had been resected for diffuse low-grade glioma-a rare tumour that migrates preferentially along associative white matter pathways. This neurological disorder constitutes an ideal pathophysiological model in which to study the functional anatomy of associative pathways. We mapped the location of each patient's resection cavity and residual lesion infiltration onto the Montreal Neurological Institute template brain and then performed multilevel lesion analyses (including conventional voxel-based lesion-symptom mapping and subtraction lesion analyses). Importantly, we estimated each associative pathway's degree of disconnection (i.e. the degree of lesion infiltration) and built specific hypotheses concerning the connective anatomy of the mentalizing subnetworks. As expected, we found that impairments in mentalizing were mainly related to the disruption of right frontoparietal connectivity. More specifically, low-level and high-level mentalizing accuracy were correlated with the degree of disconnection in the arcuate fasciculus and the cingulum, respectively. To the best of our knowledge, our findings constitute the first experimental data on the structural connectivity of the mentalizing network and suggest the existence of a dual-stream hodological system. Our results may lead to a better understanding of disorders that affect social cognition, especially in neuropathological conditions characterized by atypical/aberrant structural connectivity, such as autism spectrum disorders.

Lightning protection for shuttle propulsion elements

NASA Technical Reports Server (NTRS)

Goodloe, Carolyn C.; Giudici, Robert J.

1991-01-01

The results of lightning protection analyses and tests are weighed against the present set of waivers to the NASA lightning protection specification. The significant analyses and tests are contrasted with the release of a new and more realistic lightning protection specification, in September 1990, that resulted in an inordinate number of waivers. A variety of lightning protection analyses and tests of the Shuttle propulsion elements, the Solid Rocket Booster, the External Tank, and the Space Shuttle Main Engine, were conducted. These tests range from the sensitivity of solid propellant during shipping to penetration of cryogenic tanks during flight. The Shuttle propulsion elements have the capability to survive certain levels of lightning strikes at certain times during transportation, launch site operations, and flight. Changes are being evaluated that may improve the odds of withstanding a major lightning strike. The Solid Rocket Booster is the most likely propulsion element to survive if systems tunnel bond straps are improved. Wiring improvements were already incorporated and major protection tests were conducted. The External Tank remains vulnerable to burn-through penetration of its skin. Proposed design improvements include the use of a composite nose cone and conductive or laminated thermal protection system coatings.

Professionals' perspectives on a market-inspired policy reform: A guiding light to the blind spots of measurement.

PubMed

Korlén, Sara; Amer-Wåhlin, Isis; Lindgren, Peter; von Thiele Schwarz, Ulrica

2017-08-01

Implementation of market-inspired competition and incentive models in health care is increasing worldwide, assumed to drive efficiency. However, the evidence for effects is mixed and unintended consequences have been reported. There is a need to better understand the practical consequences of such reforms. The aim of the present case study is to explore what consequences of a Swedish market-inspired patient choice reform professionals identify as relevant, and why. The study was designed as an explorative qualitative study in specialized orthopedics. Nineteen interviews were conducted with health care professionals at different providers. Data were analyzed using a hypo-deductive thematic approach. Consequences for the organization of care, patients, work environment, education and research were included in the professionals' analyses, covering both the perspective of their own organization and that of the health care system as a whole. In sum, the professionals provided multiple-level analyses that extended beyond the responsibilities of their own organization. Concluding, professionals are a valuable source of knowledge when evaluating policy reforms. Their analyses can contribute by covering a broad system perspective, serving as a guiding light to areas beyond the most obvious evaluation measures that should be included in more formal evaluations.

Orion Flight Performance Design Trades

NASA Technical Reports Server (NTRS)

Jackson, Mark C.; Straube, Timothy

2010-01-01

A significant portion of the Orion pre-PDR design effort has focused on balancing mass with performance. High level performance metrics include abort success rates, lunar surface coverage, landing accuracy and touchdown loads. These metrics may be converted to parameters that affect mass, such as ballast for stabilizing the abort vehicle, propellant to achieve increased lunar coverage or extended missions, or ballast to increase the lift-to-drag ratio to improve entry and landing performance. The Orion Flight Dynamics team was tasked to perform analyses to evaluate many of these trades. These analyses not only provide insight into the physics of each particular trade but, in aggregate, they illustrate the processes used by Orion to balance performance and mass margins, and thereby make design decisions. Lessons learned can be gleaned from a review of these studies which will be useful to other spacecraft system designers. These lessons fall into several categories, including: appropriate application of Monte Carlo analysis in design trades, managing margin in a highly mass-constrained environment, and the use of requirements to balance margin between subsystems and components. This paper provides a review of some of the trades and analyses conducted by the Flight Dynamics team, as well as systems engineering lessons learned.

Methodology issues concerning the accuracy of kinematic data collection and analysis using the ariel performance analysis system

NASA Technical Reports Server (NTRS)

Wilmington, R. P.; Klute, Glenn K. (Editor); Carroll, Amy E. (Editor); Stuart, Mark A. (Editor); Poliner, Jeff (Editor); Rajulu, Sudhakar (Editor); Stanush, Julie (Editor)

1992-01-01

Kinematics, the study of motion exclusive of the influences of mass and force, is one of the primary methods used for the analysis of human biomechanical systems as well as other types of mechanical systems. The Anthropometry and Biomechanics Laboratory (ABL) in the Crew Interface Analysis section of the Man-Systems Division performs both human body kinematics as well as mechanical system kinematics using the Ariel Performance Analysis System (APAS). The APAS supports both analysis of analog signals (e.g. force plate data collection) as well as digitization and analysis of video data. The current evaluations address several methodology issues concerning the accuracy of the kinematic data collection and analysis used in the ABL. This document describes a series of evaluations performed to gain quantitative data pertaining to position and constant angular velocity movements under several operating conditions. Two-dimensional as well as three-dimensional data collection and analyses were completed in a controlled laboratory environment using typical hardware setups. In addition, an evaluation was performed to evaluate the accuracy impact due to a single axis camera offset. Segment length and positional data exhibited errors within 3 percent when using three-dimensional analysis and yielded errors within 8 percent through two-dimensional analysis (Direct Linear Software). Peak angular velocities displayed errors within 6 percent through three-dimensional analyses and exhibited errors of 12 percent when using two-dimensional analysis (Direct Linear Software). The specific results from this series of evaluations and their impacts on the methodology issues of kinematic data collection and analyses are presented in detail. The accuracy levels observed in these evaluations are also presented.

Antitumor activity and systemic effects of PVM/MA-shelled selol nanocapsules in lung adenocarcinoma-bearing mice

NASA Astrophysics Data System (ADS)

de Souza, Ludmilla Regina; Alexandre Muehlmann, Luis; Carneiro Matos, Lívia; Simón-Vázquez, Rosana; Guerreiro Marques Lacava, Zulmira; Maurício Batista De-Paula, Alfredo; Mosiniewicz-Szablewska, Ewa; Suchocki, Piotr; César Morais, Paulo; González-Fernández, África; Nair Báo, Sônia; Bentes Azevedo, Ricardo

2015-12-01

Selol is a semi-synthetic compound containing selenite that is effective against cancerous cells and safer for clinical applications in comparison with other inorganic forms of selenite. Recently, we have developed a formulation of poly(methyl vinyl ether-co-maleic anhydride)-shelled selol nanocapsules (SPN), which reduced the proliferative activity of lung adenocarcinoma cells and presented little deleterious effects on normal cells in in vitro studies. In this study, we report on the antitumor activity and systemic effects induced by this formulation in chemically induced lung adenocarcinoma-bearing mice. The in vivo antitumor activity of the SPN was verified by macroscopic quantification, immunohistochemistry and morphological analyses. Toxicity analyses were performed by evaluations of the kidney, liver, and spleen; analyses of hemogram and plasma levels of alanine aminotransferase, aspartate transaminase, urea, and creatinine; and DNA fragmentation and cell cycle activity of the bone marrow cells. Furthermore, we investigated the potential of the SPN formulation to cause hemolysis, activate the complement system, provoke an inflammatory response and change the conformation of the plasma proteins. Our results showed that the SPN reduced the area of the surface tumor nodules but not the total number of tumor nodules. The biochemical and hematological findings were suggestive of the low systemic toxicity of the SPN formulation. The surface properties of the selol nanocapsules point to characteristics that are consistent with the treatment of the tumors in vivo: low hemolytic activity, weak inflammatory reaction with no activation of the complement system, and mild or absent conformational changes of the plasma proteins. In conclusion, this report suggests that the SPN formulation investigated herein exhibits anti-tumoral effects against lung adenocarcinoma in vivo and is associated with low systemic toxicity and high biocompatibility.

The coevolution of play and the cortico-cerebellar system in primates.

PubMed

Kerney, Max; Smaers, Jeroen B; Schoenemann, P Thomas; Dunn, Jacob C

2017-10-01

Primates are some of the most playful animals in the natural world, yet the reason for this remains unclear. One hypothesis posits that primates are so playful because playful activity functions to help develop the sophisticated cognitive and behavioural abilities that they are also renowned for. If this hypothesis were true, then play might be expected to have coevolved with the neural substrates underlying these abilities in primates. Here, we tested this prediction by conducting phylogenetic comparative analyses to determine whether play has coevolved with the cortico-cerebellar system, a neural system known to be involved in complex cognition and the production of complex behaviour. We used phylogenetic generalised least squares analyses to compare the relative volume of the largest constituent parts of the primate cortico-cerebellar system (prefrontal cortex, non-prefrontal heteromodal cortical association areas, and posterior cerebellar hemispheres) to the mean percentage of time budget spent in play by a sample of primate species. Using a second categorical data set on play, we also used phylogenetic analysis of covariance to test for significant differences in the volume of the components of the cortico-cerebellar system among primate species exhibiting one of three different levels of adult-adult social play. Our results suggest that, in general, a positive association exists between the amount of play exhibited and the relative size of the main components of the cortico-cerebellar system in our sample of primate species. Although the explanatory power of this study is limited by the correlational nature of its analyses and by the quantity and quality of the data currently available, this finding nevertheless lends support to the hypothesis that play functions to aid the development of cognitive and behavioural abilities in primates.

Activation characteristics of candidate structural materials for a near-term Indian fusion reactor and the impact of their impurities on design considerations

NASA Astrophysics Data System (ADS)

H, L. SWAMI; C, DANANI; A, K. SHAW

2018-06-01

Activation analyses play a vital role in nuclear reactor design. Activation analyses, along with nuclear analyses, provide important information for nuclear safety and maintenance strategies. Activation analyses also help in the selection of materials for a nuclear reactor, by providing the radioactivity and dose rate levels after irradiation. This information is important to help define maintenance activity for different parts of the reactor, and to plan decommissioning and radioactive waste disposal strategies. The study of activation analyses of candidate structural materials for near-term fusion reactors or ITER is equally essential, due to the presence of a high-energy neutron environment which makes decisive demands on material selection. This study comprises two parts; in the first part the activation characteristics, in a fusion radiation environment, of several elements which are widely present in structural materials, are studied. It reveals that the presence of a few specific elements in a material can diminish its feasibility for use in the nuclear environment. The second part of the study concentrates on activation analyses of candidate structural materials for near-term fusion reactors and their comparison in fusion radiation conditions. The structural materials selected for this study, i.e. India-specific Reduced Activation Ferritic‑Martensitic steel (IN-RAFMS), P91-grade steel, stainless steel 316LN ITER-grade (SS-316LN-IG), stainless steel 316L and stainless steel 304, are candidates for use in ITER either in vessel components or test blanket systems. Tungsten is also included in this study because of its use for ITER plasma-facing components. The study is carried out using the reference parameters of the ITER fusion reactor. The activation characteristics of the materials are assessed considering the irradiation at an ITER equatorial port. The presence of elements like Nb, Mo, Co and Ta in a structural material enhance the activity level as well as the dose level, which has an impact on design considerations. IN-RAFMS was shown to be a more effective low-activation material than SS-316LN-IG.

Flight crew interface aspects of forward-looking airborne windshear detection systems

NASA Technical Reports Server (NTRS)

Anderson, Charles D.; Carbaugh, David C.

1993-01-01

The goal of this research effort was to conduct analyses and research which could provide guidelines for design of the crew interface of an integrated windshear system. Addressed were HF issues, crew/system requirements, candidate display formats, alerting criteria, and crew procedures. A survey identified five flight management issues as top priority: missed alert acceptability; avoidance distance needed; false alert acceptability; nuisance rate acceptability; and crew procedures. Results of a simulation study indicated that the warning time for a look-ahead alert needs to be between 11 and 36 seconds (target of 23 seconds) before the reactive system triggers in order to be effective. Pilots considered the standard go-around maneuver most appropriate for look-ahead alerts, and the escape maneuvers used did not require lateral turns. Prototype display formats were reviewed or developed for alerting the crew; providing guidance to avoid or escape windshear; and status displays to provide windshear situational awareness. The three alerting levels now in use were considered appropriate, with a fourth (time-critical) level as a possible addition, although many reviewers felt only two levels of alerting were needed. Another survey gathered expert opinion on what crew procedures and alerting criteria should be used for look-ahead, or integrated, windshear systems, with a wide diversity of opinion in these areas.

Drivers of health system strengthening: learning from implementation of maternal and child health programmes in Mozambique, Nepal and Rwanda.

PubMed

Samuels, Fiona; Amaya, Ana B; Balabanova, Dina

2017-09-01

There is a growing understanding that strong health systems are crucial to sustain progress. Health systems, however, are complex and much of their success depends on factors operating at different levels and outside the health system, including broader governance and political commitment to health and social development priorities. Recognizing these complexities, this article offers a pragmatic approach to exploring the drivers of progress in maternal and child health in Mozambique, Nepal and Rwanda. To do this, the article builds on a semi-systematic literature review and case study findings, designed and analysed using a multi-level framework. At the macro level, governance with effective and committed leaders was found to be vital for achieving positive health outcomes. This was underpinned by clear commitment from donors coupled by a significant increase in funding to the health sector. At the meso level, where policies are operationalized, inter-sectoral partnerships as well as decentralization and task-shifting emerged as critical. At micro (service interface) level, community-centred models and accessible and appropriately trained and incentivized local health providers play a central role in all study countries. The key drivers of progress are multiple, interrelated and transversal in terms of their operation; they are also in a constant state of flux as health systems and contexts develop. Without seeking to offer a blueprint, the study demonstrates that a 'whole-system' approach can help elicit the key drivers of change and potential pathways towards desirable outcomes. Furthermore, understanding the challenges and opportunities that are instrumental to progress at each particular level of a health system can help policy-makers and implementers to navigate this complexity and take action to strengthen health systems. © The Author 2017. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Use of the self-organising map network (SOMNet) as a decision support system for regional mental health planning.

PubMed

Chung, Younjin; Salvador-Carulla, Luis; Salinas-Pérez, José A; Uriarte-Uriarte, Jose J; Iruin-Sanz, Alvaro; García-Alonso, Carlos R

2018-04-25

Decision-making in mental health systems should be supported by the evidence-informed knowledge transfer of data. Since mental health systems are inherently complex, involving interactions between its structures, processes and outcomes, decision support systems (DSS) need to be developed using advanced computational methods and visual tools to allow full system analysis, whilst incorporating domain experts in the analysis process. In this study, we use a DSS model developed for interactive data mining and domain expert collaboration in the analysis of complex mental health systems to improve system knowledge and evidence-informed policy planning. We combine an interactive visual data mining approach, the self-organising map network (SOMNet), with an operational expert knowledge approach, expert-based collaborative analysis (EbCA), to develop a DSS model. The SOMNet was applied to the analysis of healthcare patterns and indicators of three different regional mental health systems in Spain, comprising 106 small catchment areas and providing healthcare for over 9 million inhabitants. Based on the EbCA, the domain experts in the development team guided and evaluated the analytical processes and results. Another group of 13 domain experts in mental health systems planning and research evaluated the model based on the analytical information of the SOMNet approach for processing information and discovering knowledge in a real-world context. Through the evaluation, the domain experts assessed the feasibility and technology readiness level (TRL) of the DSS model. The SOMNet, combined with the EbCA, effectively processed evidence-based information when analysing system outliers, explaining global and local patterns, and refining key performance indicators with their analytical interpretations. The evaluation results showed that the DSS model was feasible by the domain experts and reached level 7 of the TRL (system prototype demonstration in operational environment). This study supports the benefits of combining health systems engineering (SOMNet) and expert knowledge (EbCA) to analyse the complexity of health systems research. The use of the SOMNet approach contributes to the demonstration of DSS for mental health planning in practice.