The use of inflatable structures for re-entry of orbiting vehicles

NASA Astrophysics Data System (ADS)

Kendall, Robert T.; Maddox, Arthur R.

1990-10-01

Inflatable recovery systems offer the unique advantage that a large high-drag shape can be stored initially in a relatively small package. The resulting shapes decelerate rapidly with lower heating inputs than other types of re-entry vehicles. Recent developments have led to some light-weight materials, with little thermal protection, can withstand the heating inputs to such vehicles. As a result, inflatable recovery vehicles offer a simple, reliable and economical way to return various vehicles from orbit. This paper examines the application of this concept to a large and a small vehicle with the accompanying dynamics that might be expected. More complex systems could extend the concept to emergency personnel escape systems, payload abort and satellite recovery systems.

Cluster Analysis of Adolescent Blogs

ERIC Educational Resources Information Center

Liu, Eric Zhi-Feng; Lin, Chun-Hung; Chen, Feng-Yi; Peng, Ping-Chuan

2012-01-01

Emerging web applications and networking systems such as blogs have become popular, and they offer unique opportunities and environments for learners, especially for adolescent learners. This study attempts to explore the writing styles and genres used by adolescents in their blogs by employing content, factor, and cluster analyses. Factor…

Using Distance Education To Teach Educational Leadership.

ERIC Educational Resources Information Center

Van Patten, James J.; Holt, Carleton

Educational administrator preparation is facing challenges in keeping up with rapidly changing delivery systems, as well as dealing with a shortage of well-trained school principals and superintendents. Distance learning offers an opportunity to serve diverse populations with a focus on individual uniqueness, needs, and concerns. Technology can…

A Course in Real-Time Embedded Software

ERIC Educational Resources Information Center

Archibald, J. K.; Fife, W. S.

2007-01-01

Embedded systems are increasingly pervasive, and the creation of reliable controlling software offers unique challenges. Embedded software must interact directly with hardware, it must respond to events in a time-critical fashion, and it typically employs concurrency to meet response time requirements. This paper describes an innovative course…

Reference Function with an On-Line Catalog

ERIC Educational Resources Information Center

Winik, Ruth

1972-01-01

The automated Experimental Library Management System (ELMS) in use at the IBM Los Gatos Laboratory has proved to offer unique advantages in fulfilling the reference function. All records of the library, including complete bibliographic descriptions, order information and circulation status, are available at the librarian's fingertips at the…

Graduate Education through Telecommunications: The Computer and You.

ERIC Educational Resources Information Center

Mizell, Al P.

Providing a variety of instructional methods and materials, developing unique and effective communication systems, and evaluating the process are keys to the delivery and effectiveness of the field-based programs in graduate education offered by Nova Southeastern University (Florida). This 4-year nonprofit institution is a leader in distance…

Multispectral remote sensing from unmanned aircraft: image processing workflows and applications for rangeland environments

USDA-ARS?s Scientific Manuscript database

Using unmanned aircraft systems (UAS) as remote sensing platforms offers the unique ability for repeated deployment for acquisition of high temporal resolution data at very high spatial resolution. Most image acquisitions from UAS have been in the visible bands, while multispectral remote sensing ap...

The LMS Selection Process: Practices and Considerations. ECAR Research Bulletin

ERIC Educational Resources Information Center

Cavanagh, Thomas B.

2014-01-01

With more than 80% of institutions offering online learning options and even more using web technologies to enhance traditional classroom instruction, the learning management system (LMS) is increasingly an indispensable, enterprise-level technology for today's colleges and universities. Naturally, each institution has a unique set of…

Visual Neuroscience: Unique Neural System for Flight Stabilization in Hummingbirds.

PubMed

Ibbotson, M R

2017-01-23

The pretectal visual motion processing area in the hummingbird brain is unlike that in other birds: instead of emphasizing detection of horizontal movements, it codes for motion in all directions through 360°, possibly offering precise visual stability control during hovering. Copyright © 2017 Elsevier Ltd. All rights reserved.

Investigation of charge coupled device correlation techniques

NASA Technical Reports Server (NTRS)

Lampe, D. R.; Lin, H. C.; Shutt, T. J.

1978-01-01

Analog Charge Transfer Devices (CTD's) offer unique advantages to signal processing systems, which often have large development costs, making it desirable to define those devices which can be developed for general system's use. Such devices are best identified and developed early to give system's designers some interchangeable subsystem blocks, not requiring additional individual development for each new signal processing system. The objective of this work is to describe a discrete analog signal processing device with a reasonably broad system use and to implement its design, fabrication, and testing.

Development and Optimization of Viable Human Platforms through 3D Printing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parker, Paul R.; Moya, Monica L.; Wheeler, Elizabeth K.

2015-08-21

3D printing technology offers a unique method for creating cell cultures in a manner far more conducive to accurate representation of human tissues and systems. Here we print cellular structures capable of forming vascular networks and exhibiting qualities of natural tissues and human systems. This allows for cheaper and readily available sources for further study of biological and pharmaceutical agents.

Corral Monitoring System assessment results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Filby, E.E.; Haskel, K.J.

1998-03-01

This report describes the results of a functional and operational assessment of the Corral Monitoring Systems (CMS), which was designed to detect and document accountable items entering or leaving a monitored site. Its development was motivated by the possibility that multiple sites in the nuclear weapons states of the former Soviet Union might be opened to such monitoring under the provisions of the Strategic Arms Reduction Treaty. The assessment was performed at three levels. One level evaluated how well the planned approach addressed the target application, and which involved tracking sensitive items moving into and around a site being monitoredmore » as part of an international treaty or other agreement. The second level examined the overall design and development approach, while the third focused on individual subsystems within the total package. Unfortunately, the system was delivered as disassembled parts and pieces, with very poor documentation. Thus, the assessment was based on fragmentary operating data coupled with an analysis of what documents were provided with the system. The system design seemed to be a reasonable match to the requirements of the target application; however, important questions about site manning and top level administrative control were left unanswered. Four weaknesses in the overall design and development approach were detected: (1) poor configuration control and management, (2) inadequate adherence to a well defined architectural standard, (3) no apparent provision for improving top level error tolerance, and (4) weaknesses in the object oriented programming approach. The individual subsystems were found to offer few features or capabilities that were new or unique, even at the conceptual level. The CMS might possibly have offered a unique combination of features, but this level of integration was never realized, and it had no unique capabilities that could be readily extracted for use in another system.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bluestein, J.; Horgan, S.; Eldridge, M. M.

Relatively small projects for generating electrical power at or near the point of use--distributed generation (DG)--offer unique opportunities for enhancing the U.S. electric system. This report finds that current air quality regulatory practices are inappropriately inhibiting the development of DG through a failure to recognize the environmental benefits offered by DG or by imposing requirements designed for larger systems that are not appropriate to DG systems. The report recommends that air quality regulation be made more efficient and appropriate for DG by establishing national standards for DG equipment. This report also recommends that DG projects be evaluated on a''net'' emissionsmore » basis by being given credit for any emission sources that they displace. Air quality regulation should also recognize the benefits of combined heat and power (CHP).« less

High-frequency applications of high-temperature superconductor thin films

NASA Astrophysics Data System (ADS)

Klein, N.

2002-10-01

High-temperature superconducting thin films offer unique properties which can be utilized for a variety of high-frequency device applications in many areas related to the strongly progressing market of information technology. One important property is an exceptionally low level of microwave absorption at temperatures attainable with low power cryocoolers. This unique property has initiated the development of various novel type of microwave devices and commercialized subsystems with special emphasis on application in advanced microwave communication systems. The second important achievement related to efforts in oxide thin and multilayer technology was the reproducible fabrication of low-noise Josephson junctions in high-temperature superconducting thin films. As a consequence of this achievement, several novel nonlinear high-frequency devices, most of them exploiting the unique features of the ac Josephson effect, have been developed and found to exhibit challenging properties to be utilized in basic metrology and Terahertz technology. On the longer timescale, the achievements in integrated high-temperature superconductor circuit technology may offer a strong potential for the development of digital devices with possible clock frequencies in the range of 100 GHz.

NASA Earth Observation Systems and Applications for Health: Moving from Research to Operational End Users

NASA Astrophysics Data System (ADS)

Haynes, J.; Estes, S. M.

2017-12-01

Health providers and researchers need environmental data to study and understand the geographic, environmental, and meteorological differences in disease. Satellite remote sensing of the environment offers a unique vantage point that can fill in the gaps of environmental, spatial, and temporal data for tracking disease. This presentation will demonstrate NASA's applied science programs efforts to transition from research to operations to benefit society. Satellite earth observations present a unique vantage point of the earth's environment from space, which offers a wealth of health applications for the imaginative investigator. The presentation is directly related to Earth Observing systems and Global Health Surveillance and will present research results of the remote sensing environmental observations of earth and health applications, which can contribute to the health research. As part of NASA approach and methodology they have used Earth Observation Systems and Applications for Health Models to provide a method for bridging gaps of environmental, spatial, and temporal data for tracking disease. This presentation will provide a venue where the results of both research and practice using satellite earth observations to study weather and it's role in health research and the transition to operational end users.

Experimental Overview of Direct Photon Results in Heavy Ion Collisions

NASA Astrophysics Data System (ADS)

Novitzky, Norbert

2016-07-01

Direct photons are color blind probes and thus they provide unique opportunities to study the colored medium created in heavy ion collisions. There are many different sources of direct photons each probing different physics processes as the system evolves. In basic 2 → 2 processes the prompt photons from primary hard scatterings offer the most precise measurements of the outgoing parton energy in the opposite direction. In heavy ion collisions the created medium emits photons as thermal radiation, whose rate and anisotropies provide a unique prospective on the properties and evolution of the system. Recent results on direct photons from the LHC and RHIC experiments are briefly summarized in this paper.

The potential of space exploration for education

NASA Technical Reports Server (NTRS)

Shair, Fredrick H.

1993-01-01

Space exploration and observations from space offer unique opportunities with respect to education. Recent technical advances have significantly increased the width and sensitivity of the electromagnetic spectrum window through which we are able to 'see' the universe. Observations from space have forced a realization that the earth is a beautiful, complex, and interconnected system. Space astronomy and the remote sensing of objects throughout our solar system have the potential of providing unique educational opportunities. Modern technologies have significantly reduced the cost of collecting, transmitting and processing data. Consequently, we are entering an age where it is possible to open up the process of discovery to almost everyone - and especially to young people throughout the world.

Mapping Residency Global Health Experiences to the ACGME Family Medicine Milestones.

PubMed

Grissom, Maureen O; Iroku-Malize, Tochi; Peila, Rita; Perez, Marco; Philippe, Neubert

2017-07-01

Global health (GH) experiences are a unique part of family medicine (FM) training that offer an opportunity for residents to demonstrate development across a multitude of the milestones recently implemented by the Accreditation Council for Graduate Medical Education (ACGME). The GH experience presents an opportunity for resident development, and including a component of written reflection can provide tangible evidence of development in areas that can be difficult to assess. A mixed methods approach was used to integrate quantitative (frequency) data with qualitative content from the written reflections of 12 of our FM residents who participated in GH experiences. Written reflections touched on each of the 22 milestones, although some milestones were noted more frequently than others. The most commonly identified milestones fell within the competency areas of systems-based practice, professionalism, and practice-based learning and improvement. Our qualitative approach allowed us to gain an appreciation of the unique experiences that demonstrated growth across the various milestones. We conclude that any program that offers GH experiences should incorporate some form of written reflection to maximize resident growth and offer evaluative faculty a window into that development.

Detection of Ionospheric Alfven Resonator Signatures in the Equatorial Ionosphere

NASA Technical Reports Server (NTRS)

Simoes, Fernando; Klenzing, Jeffrey; Ivanov, Stoyan; Pfaff, Robert; Freudenreich, Henry; Bilitza, Dieter; Rowland, Douglas; Bromund, Kenneth; Liebrecht, Maria Carmen; Martin, Steven;

Performance-Pay for Teachers: Designing a System That Students Deserve

ERIC Educational Resources Information Center

Center for Teaching Quality, 2007

2007-01-01

Eighteen highly accomplished and diverse teachers from across America have spent the last year studying various efforts in creating alternatives in the way that teachers have been traditionally compensated. In this report, these educators offer unique solutions based on their understanding of the professional work of teachers, the best current…

A Comparison of the Two Leading Electronic Braille Notetakers.

ERIC Educational Resources Information Center

Leventhal, J. D.; Uslan, M. M.

1992-01-01

Comparison of two electronic braille notetakers found that the Braille 'n Speak was less expensive, easier to learn, and easier for both experienced users and beginners to operate than the BrailleMate, though the BrailleMate offers a unique alternative by including a braille display and a Random Access Memory card storage system. (JDD)

Neurobiological Correlates of Psychosocial Deprivation in Children: A Systematic Review of Neuroscientific Contributions

ERIC Educational Resources Information Center

Perego, Gaia; Caputi, Marcella; Ogliari, Anna

2016-01-01

Background: Institutionalization from birth offers a unique opportunity to investigate the effects on brain and endocrine system of psychosocial deprivation in early infancy. Nonetheless, a systematic review about institutionalization and biological anomalies does not exist. Objective: The purpose of this paper was to systematize all the studies…

Bringing an ecological view of change to Landsat-based remote sensing

Treesearch

Robert E. Kennedy; Serge Andrefouet; Warren B. Cohen; Cristina Gomez; Patrick Griffiths; Martin Hais; Sean P. Healey; Eileen H. Helmer; Patrick Hostert; Mitchell B. Lyons; Garrett W. Meigs; Dirk Pflugmacher; Stuart R. Phinn; Scott L. Powell; Peter Scarth; Susmita Sen; Todd A. Schroeder; Annemarie Schneider; Ruth Sonnenschein; James E. Vogelmann; Michael A. Wulder; Zhe Zhu

2014-01-01

When characterizing the processes that shape ecosystems, ecologists increasingly use the unique perspective offered by repeat observations of remotely sensed imagery. However, the concept of change embodied in much of the traditional remote-sensing literature was primarily limited to capturing large or extreme changes occurring in natural systems, omitting many more...

Thermoelectrics as elements of hybrid-electric vehicle thermal energy systems

NASA Astrophysics Data System (ADS)

Headings, Leon; Washington, Gregory; Jaworski, Christopher M.

2008-03-01

Despite vast technological improvements, the traditional internal combustion powered vehicle still achieves only 25- 30% efficiency, with the remainder lost primarily as heat. While the load leveling offered by hybrid-electric vehicle technology helps to improve this overall efficiency, part of the efficiency gains are achieved by making new systems such as regenerative braking viable. In a similar fashion, thermoelectric (TE) energy recovery has long been considered for traditional vehicles with mixed results, but little has been done to consider thermoelectrics in the framework of the unique energy systems of hybrid vehicles. Systems that may not have been viable or even possible with traditional vehicles may offer improvements to system efficiency as well as emissions, vehicle durability, passenger comfort, and cost. This research describes a simulation developed for evaluating and optimizing thermoelectric energy recovery systems and results for four different system configurations. Two novel system configurations are presented which offer the potential for additional benefits such as emissions reduction that will soon be quantified. In addition, a test setup is presented which was constructed for the testing and validation of various thermoelectric recovery systems. Actual test performance was near the expected theoretical performance and supported the conclusions reached from the computer simulations.

Issues in International Energy Consumption Analysis: Electricity Usage in India’s Housing Sector

EIA Publications

2014-01-01

India offers a unique set of features for studying electricity use in the context of a developing country. First, it has a rapidly developing economy with high yearly growth rates in gross domestic product (GDP). Second, it has the second -largest population in the world and is likely to have the largest population in the future. Third, its electric system is maturing—with known difficulties (outages, shortages, issues with reliability and quality) that are characteristic of a developing country. This article focuses on electricity use in the residential sector of India and discusses key trends and provides an overview of available usage estimates from various sources. Indian households are an interesting environment where many of India’s unique features interact. The recent economic gains correlate with rising incomes and possible changes in living standards, which could affect electricity or other energy use within households. Additionally, the maturing electric system and large population in India both offer opportunities to study a range of interactions between electrification and electricity usage in a developing country.

The Differential Effect of Basic Mathematics Skills Homework via a Web-Based Intelligent Tutoring System across Achievement Subgroups and Mathematics Domains: A Randomized Field Experiment

ERIC Educational Resources Information Center

Bartelet, Dimona; Ghysels, Joris; Groot, Wim; Haelermans, Carla; van den Brink, Henriëtte Maassen

2016-01-01

This article examines an educational experiment with a unique combination of 3 elements: homework, the use of information and communication technology and a large degree of freedom of choice (student autonomy). More particularly, we study the effectiveness of a web-based intelligent tutoring system (ITS) that a school offers to its students as…

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

PubMed Central

Gao, Weiwei; Zhang, Yue; Zhang, Qiangzhe; Zhang, Liangfang

2016-01-01

Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery. PMID:26951462

Stimuli-responsive chitosan-based nanocarriers for cancer therapy

PubMed Central

Fathi, Marziyeh; Sahandi Zangabad, Parham; Majidi, Sima; Barar, Jaleh; Erfan-Niya, Hamid

2017-01-01

Introduction: Stimuli-responsive nanocarriers offer unique advantages over the traditional drug delivery systems (DDSs) in terms of targeted drug delivery and on-demand release of cargo drug molecules. Of these, chitosan (CS)-based DDSs offer several advantages such as high compatibility with biological settings. Methods: In this study, we surveyed the literature in terms of the stimuli-responsive nanocarriers and discussed the most recent advancements in terms of CS-based nanosystems and their applications in cancer therapy and diagnosis. Results: These advanced DDSs are able to release the entrapped drugs in response to a specific endogenous stimulus (e.g., pH, glutathione concentration or certain enzymes) or exogenous stimulus (e.g., temperature, light, ultrasound, and magnetic field) at the desired time and target site. Dual-responsive nanocarriers by the combination of different stimuli have also been developed as efficient and improved DDSs. Among the stimuli-responsive nanocarriers, CS-based DDSs offer several advantages, including biocompatibility and biodegradability, antibacterial activity, ease of modification and functionalization, and non-immunogenicity. They are as one of the most ideal smart multifunction DDSs. Conclusion: The CS-based stimuli-responsive multifunctional nanosystems (NSs) offer unique potential for the targeted delivery of anticancer agents and provide great potential for on-demand and controlled-release of anticancer agents in response to diverse external/internal stimuli. PMID:29435435

Stimuli-responsive chitosan-based nanocarriers for cancer therapy.

PubMed

Fathi, Marziyeh; Sahandi Zangabad, Parham; Majidi, Sima; Barar, Jaleh; Erfan-Niya, Hamid; Omidi, Yadollah

2017-01-01

Introduction: Stimuli-responsive nanocarriers offer unique advantages over the traditional drug delivery systems (DDSs) in terms of targeted drug delivery and on-demand release of cargo drug molecules. Of these, chitosan (CS)-based DDSs offer several advantages such as high compatibility with biological settings. Methods: In this study, we surveyed the literature in terms of the stimuli-responsive nanocarriers and discussed the most recent advancements in terms of CS-based nanosystems and their applications in cancer therapy and diagnosis. Results: These advanced DDSs are able to release the entrapped drugs in response to a specific endogenous stimulus (e.g., pH, glutathione concentration or certain enzymes) or exogenous stimulus (e.g., temperature, light, ultrasound, and magnetic field) at the desired time and target site. Dual-responsive nanocarriers by the combination of different stimuli have also been developed as efficient and improved DDSs. Among the stimuli-responsive nanocarriers, CS-based DDSs offer several advantages, including biocompatibility and biodegradability, antibacterial activity, ease of modification and functionalization, and non-immunogenicity. They are as one of the most ideal smart multifunction DDSs. Conclusion: The CS-based stimuli-responsive multifunctional nanosystems (NSs) offer unique potential for the targeted delivery of anticancer agents and provide great potential for on-demand and controlled-release of anticancer agents in response to diverse external/internal stimuli.

Japan's advanced medicine.

PubMed

Sho, Ri; Narimatsu, Hiroto; Murakami, Masayasu

2013-10-01

Like health care systems in other developed countries, Japan's health care system faces significant challenges due to aging of the population and economic stagnation. Advanced medicine (Senshin Iryou) is a unique system of medical care in Japan offering highly technology-driven medical care that is not covered by public health insurance. Advanced medicine has recently developed and expanded as part of health care reform. Will it work? To answer this question, we briefly trace the historical development of advanced medicine and describe the characteristics and current state of advanced medical care in Japan. We then offer our opinions on the future of advanced medicine with careful consideration of its pros and cons. We believe that developing advanced medicine is an attempt to bring health care reform in line rather than the goal of health care reform.

Microbial Fuel Cells and Microbial Ecology: Applications in Ruminant Health and Production Research

PubMed Central

Osterstock, Jason B.; Pinchak, William E.; Ishii, Shun’ichi; Nelson, Karen E.

2009-01-01

Microbial fuel cell (MFC) systems employ the catalytic activity of microbes to produce electricity from the oxidation of organic, and in some cases inorganic, substrates. MFC systems have been primarily explored for their use in bioremediation and bioenergy applications; however, these systems also offer a unique strategy for the cultivation of synergistic microbial communities. It has been hypothesized that the mechanism(s) of microbial electron transfer that enable electricity production in MFCs may be a cooperative strategy within mixed microbial consortia that is associated with, or is an alternative to, interspecies hydrogen (H2) transfer. Microbial fermentation processes and methanogenesis in ruminant animals are highly dependent on the consumption and production of H2in the rumen. Given the crucial role that H2 plays in ruminant digestion, it is desirable to understand the microbial relationships that control H2 partial pressures within the rumen; MFCs may serve as unique tools for studying this complex ecological system. Further, MFC systems offer a novel approach to studying biofilms that form under different redox conditions and may be applied to achieve a greater understanding of how microbial biofilms impact animal health. Here, we present a brief summary of the efforts made towards understanding rumen microbial ecology, microbial biofilms related to animal health, and how MFCs may be further applied in ruminant research. PMID:20024685

ELM-ART--An Interactive and Intelligent Web-Based Electronic Textbook

ERIC Educational Resources Information Center

Weber, Gerhard; Brusilovsky, Peter

2016-01-01

This paper present provides a broader view on ELM-ART, one of the first Web-based Intelligent Educational systems that offered a creative combination of two different paradigms--Intelligent Tutoring and Adaptive Hypermedia technologies. The unique dual nature of ELM-ART contributed to its long life and research impact and was a result of…

Guitars, Keyboards, Strobes, and Motors--From Vibrational Motion to Active Research

ERIC Educational Resources Information Center

Tagg, Randall; Carlson, John; Asadi-Zeydabadi, Masoud; Busley, Brad; Law-Balding, Katie; Juengel, Mattea

2013-01-01

Physics First is offered to ninth graders at high schools in Aurora, CO. A unique new asset of this school system is an embedded research lab called the "Innovation Hyperlab." The goal of the lab is to connect secondary school teaching to ongoing university scientific research, supporting the school district's aim to create opportunities to…

Student Perceptions of Engagement Using Mobile-Based Polling as an Audience Response System: Implications for Leadership Studies

ERIC Educational Resources Information Center

Noel, Dan; Stover, Sheri; McNutt, Mindy

2015-01-01

The increase in ownership and use of mobile-based devices among college students creates unique opportunities for faculty to develop highly engaging learning environments. With many educational institutions offering campus-wide Wi-Fi, students have the ability to use their mobile devices, including cell phones, tablets, and laptops for engaging…

Advanced energy system program

NASA Astrophysics Data System (ADS)

Trester, K.

1989-02-01

The objectives of the program are to design, develop and demonstrate a natural-gas-fueled, highly recuperated, 50 kW Brayton-cycle cogeneration system for commercial, institutional, and multifamily residential applications. Marketing studies have shown that this Advanced Energy System (AES), with its many unique and cost-effective features, has the potential to offer significant reductions in annual electrical and thermal energy costs to the consumer. Specific advantages of the system that result in low cost of ownership are high electrical efficiency (30 percent, HHV), low maintenance, high reliability and long life (20 years).

NASA's Space Launch System: An Evolving Capability for Exploration

NASA Technical Reports Server (NTRS)

Robinson, Kimberly F.; Hefner, Keith; Hitt, David

2015-01-01

Designed to enable human space exploration missions, including eventually landings on Mars, NASA's Space Launch System (SLS) represents a unique launch capability with a wide range of utilization opportunities, from delivering habitation systems into the lunar vicinity to high-energy transits through the outer solar system. The vehicle will be able to deliver greater mass to orbit than any contemporary launch vehicle. SLS will also be able to carry larger payload fairings than any contemporary launch vehicle, and will offer opportunities for co-manifested and secondary payloads.

Energy Systems Test Area (ESTA) Pyrotechnic Operations: User Test Planning Guide

NASA Technical Reports Server (NTRS)

Hacker, Scott

2012-01-01

The Johnson Space Center (JSC) has created and refined innovative analysis, design, development, and testing techniques that have been demonstrated in all phases of spaceflight. JSC is uniquely positioned to apply this expertise to components, systems, and vehicles that operate in remote or harsh environments. We offer a highly skilled workforce, unique facilities, flexible project management, and a proven management system. The purpose of this guide is to acquaint Test Requesters with the requirements for test, analysis, or simulation services at JSC. The guide includes facility services and capabilities, inputs required by the facility, major milestones, a roadmap of the facility s process, and roles and responsibilities of the facility and the requester. Samples of deliverables, facility interfaces, and inputs necessary to define the cost and schedule are included as appendices to the guide.

Fathers' Role in Play: Enhancing Early Language and Literacy of Children with Developmental Delays

ERIC Educational Resources Information Center

Stockall, Nancy; Dennis, Lindsay

2013-01-01

Fathers and paternal role models make a unique contribution to children's development. There is some research to suggest that the types of play males engage in with children is typically more active and thus offers unique possibilities for embedding activities for language and literacy development. In this article, we offer suggestions for how…

TPV power source development for an unmanned undersea vehicle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holmquist, G.A.

The thermophotovoltaic (TPV) generation of electrical power promises efficiencies that are exploitable for military and commercial applications. TPV offers a combination of unique characteristics as a power source for military Unmanned Undersea Vehicles. In civilian applications TPV technology offers the potential for lightweight, rugged, and reliable power systems that can be environmentally benign. These systems can use a variety of fuels and can be scaled up in size. TPV is truly a dual use technology in which the United States appears to have a technical lead. The focus of the current Quantum program is the maturation of the technology andmore » the demonstration of a 10 kilowatt generator. Preliminary results of this project are presented.« less

NASA Puffin Electric Tailsitter VTOL Concept

NASA Technical Reports Server (NTRS)

Moore, Mark D.

2010-01-01

Electric propulsion offers dramatic new vehicle mission capabilities, not possible with turbine or reciprocating engines; including high reliability and efficiency, low engine weight and maintenance, low cooling drag and volume required, very low noise and vibration, and zero emissions. The only penalizing characteristic of electric propulsion is the current energy storage technology level, which is set to triple over the next 5-10 years through huge new investments in this field. Most importantly, electric propulsion offers incredible new degrees of freedom in aircraft system integration to achieve unprecedented levels of aerodynamic, propulsive, control, and structural synergistic coupling. A unique characteristic of electric propulsion is that the technology is nearly scale-free, permitting small motors to be parallelized for fail-safe redundancy, or distributed across the airframe for tightly coupled interdisciplinary functionality without significant impacts in motor-controller efficiency or specific weight. Maximizing the potential benefit of electric propulsion is dependent on applying this technology to synergistic mission concepts. The vehicle missions with the most benefit include those which constrain environmental impact (or limit noise, exhaust, or emission signatures) are short range, or where large differences exist in the propulsion system sizing between takeoff and cruise conditions. Electric propulsion offers the following unique capabilities that other propulsion systems can t provide for short range Vertical Takeoff and Landing (VTOL) aircraft; elimination of engine noise and emissions, drastic reduction in engine cooling and radiated heat, drastic reduction in vehicle vibration levels, drastic improvement in reliability and operating costs, variable speed output at full power, for improved cruise efficiency at low tip-speed, elimination of high/hot sizing penalty, and reduction of engine-out penalties.

Qubit-Based Memcapacitors and Meminductors

NASA Astrophysics Data System (ADS)

Shevchenko, Sergey N.; Pershin, Yuriy V.; Nori, Franco

2016-07-01

It is shown that superconducting charge and flux quantum bits (qubits) can be classified as memory capacitive and inductive systems, respectively. We demonstrate that such memcapacitive and meminductive devices offer remarkable and rich response functionalities. In particular, when subjected to periodic input, qubit-based memcapacitors and meminductors exhibit unusual hysteresis curves. Our work not only extends the set of known memcapacitive and meminductive systems to qubit-based devices, but also highlights their unique properties potentially useful for future technological applications.

Mergers and acquisitions in professional organizations: a complex adaptive systems approach.

PubMed

Walls, M E; McDaniel, R R

1999-09-01

Nurse managers face unique challenges as they cope with mergers and acquisitions among health care organizations. These challenges can be better understood if it is recognized that health care institutions are professional organizations and that the transformations required are extremely difficult. These difficulties are caused, in part, by the institutionalized nature of professional organizations, and this nature is explicated. Professional organizations are stubborn. They are repositories of expertise and values that are societal in origin and difficult to change. When professional organizations are understood as complex adaptive systems, complexity theory offers insight that provide strategies for managing mergers and acquisitions that may not be apparent when more traditional conceptualizations of professional organizations are used. Specific managerial techniques consistent with both the institutionalized characteristics and the complex adaptive systems characteristics of professional organizations are offered to nurse managers.

Designing Mission Operations for the Gravity Recovery and Interior Laboratory Mission

NASA Technical Reports Server (NTRS)

Havens, Glen G.; Beerer, Joseph G.

2012-01-01

NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission, to understand the internal structure and thermal evolution of the Moon, offered unique challenges to mission operations. From launch through end of mission, the twin GRAIL orbiters had to be operated in parallel. The journey to the Moon and into the low science orbit involved numerous maneuvers, planned on tight timelines, to ultimately place the orbiters into the required formation-flying configuration necessary. The baseline GRAIL mission is short, only 9 months in duration, but progressed quickly through seven very unique mission phases. Compressed into this short mission timeline, operations activities and maneuvers for both orbiters had to be planned and coordinated carefully. To prepare for these challenges, development of the GRAIL Mission Operations System began in 2008. Based on high heritage multi-mission operations developed by NASA's Jet Propulsion Laboratory and Lockheed Martin, the GRAIL mission operations system was adapted to meet the unique challenges posed by the GRAIL mission design. This paper describes GRAIL's system engineering development process for defining GRAIL's operations scenarios and generating requirements, tracing the evolution from operations concept through final design, implementation, and validation.

A Comparison of Success and Failure Rates between Computer-Assisted and Traditional College Algebra Sections

ERIC Educational Resources Information Center

Herron, Sherry; Gandy, Rex; Ye, Ningjun; Syed, Nasser

2012-01-01

A unique aspect of the implementation of a computer algebra system (CAS) at a comprehensive university in the U.S. allowed us to compare the student success and failure rates to the traditional method of teaching college algebra. Due to space limitations, the university offered sections of both CAS and traditional simultaneously and, upon…

BoneSource hydroxyapatite cement: a novel biomaterial for craniofacial skeletal tissue engineering and reconstruction.

PubMed

Friedman, C D; Costantino, P D; Takagi, S; Chow, L C

1998-01-01

BoneSource-hydroxyapatite cement is a new self-setting calcium phosphate cement biomaterial. Its unique and innovative physical chemistry coupled with enhanced biocompatibility make it useful for craniofacial skeletal reconstruction. The general properties and clinical use guidelines are reviewed. The biomaterial and surgical applications offer insight into improved outcomes and potential new uses for hydroxyapatite cement systems.

A Time Profile of Mathematics in a "Gap Year" in Irish Secondary Schools

ERIC Educational Resources Information Center

Prendergast, Mark; O'Meara, Niamh

2016-01-01

The Irish education system is unique in an international context as it sets aside a full school year for a transition and youth development programme in the middle of secondary education. The Transition Year (TY) programme is an optional, full time programme offered in the majority of secondary schools. Each school designs its own programme,…

Survey of Advanced Applications Over ACTS

NASA Technical Reports Server (NTRS)

Bauer, Robert; McMasters, Paul

2000-01-01

The Advanced Communications Technology Satellite (ACTS) system provided a national testbed that enabled advanced applications to be tested and demonstrated over a live satellite link. Of the applications that used ACTS. some offered unique advantages over current methods, while others simply could not be accommodated by conventional systems. The initial technical and experiments results of the program were reported at the 1995 ACTS Results Conference. in Cleveland, Ohio. Since then, the Experiments Program has involved 45 new experiments comprising 30 application experiments and 15 technology related experiments that took advantage of the advanced technologies and unique capabilities offered by ACTS. The experiments are categorized and quantified to show the organizational mix of the experiments program and relative usage of the satellite. Since paper length guidelines preclude each experiment from being individually reported, the application experiments and significant demonstrations are surveyed to show the breadth of the activities that have been supported. Experiments in a similar application category are collectively discussed, such as. telemedicine. or networking and protocol evaluation. Where available. experiment conclusions and impact are presented and references of results and experiment information are provided. The quantity and diversity of the experiments program demonstrated a variety of service areas for the next generation of commercially available, advanced satellite communications.

Converting information from paper to optical media

NASA Technical Reports Server (NTRS)

Deaton, Timothy N.; Tiller, Bruce K.

1990-01-01

The technology of converting large amounts of paper into electronic form is described for use in information management systems based on optical disk storage. The space savings and photographic nature of microfiche are combined in these systems with the advantages of computerized data (fast and flexible retrieval of graphics and text, simultaneous instant access for multiple users, and easy manipulation of data). It is noted that electronic imaging systems offer a unique opportunity to dramatically increase the productivity and profitability of information systems. Particular attention is given to the CALS (Computer-aided Aquisition and Logistic Support) system.

High performance optical payloads for microsatellites

NASA Astrophysics Data System (ADS)

Geyl, Roland; Rodolfo, Jacques; Girault, Jean-Philippe

2017-09-01

Safran is presenting two concepts of optical payloads for microsatellites combining high performances and extremely compact volume. The first one offer 10-m Ground Sampling Distance (GSD) over 60x40 km2 area from 600 km orbit optimized for twilight conditions. The second one is offering a much higher resolution of 1.8-m over 11x7,5 km2 area from the same 600 km orbit. The two concepts are based on advanced innovative diffraction limited optical system packaged in a unique very compact volume lower than 8U = 200x200x200 mm making them the ideal solution for 15- 100 kg microsatellites. The maximum number of pixels is served to the end-user space imagery community thanks to 35 mm Full Frame sensors offering, as of today, 6000x4000 pixels. Up to 10 spectral bands from 475 to 900 nm can be offered thanks to 2D structured filters.

Quantum dot behavior in transition metal dichalcogenides nanostructures

NASA Astrophysics Data System (ADS)

Luo, Gang; Zhang, Zhuo-Zhi; Li, Hai-Ou; Song, Xiang-Xiang; Deng, Guang-Wei; Cao, Gang; Xiao, Ming; Guo, Guo-Ping

2017-08-01

Recently, transition metal dichalcogenides (TMDCs) semiconductors have been utilized for investigating quantum phenomena because of their unique band structures and novel electronic properties. In a quantum dot (QD), electrons are confined in all lateral dimensions, offering the possibility for detailed investigation and controlled manipulation of individual quantum systems. Beyond the definition of graphene QDs by opening an energy gap in nanoconstrictions, with the presence of a bandgap, gate-defined QDs can be achieved on TMDCs semiconductors. In this paper, we review the confinement and transport of QDs in TMDCs nanostructures. The fabrication techniques for demonstrating two-dimensional (2D) materials nanostructures such as field-effect transistors and QDs, mainly based on e-beam lithography and transfer assembly techniques are discussed. Subsequently, we focus on electron transport through TMDCs nanostructures and QDs. With steady improvement in nanoscale materials characterization and using graphene as a springboard, 2D materials offer a platform that allows creation of heterostructure QDs integrated with a variety of crystals, each of which has entirely unique physical properties.

PERCEPT: indoor navigation for the blind and visually impaired.

PubMed

Ganz, Aura; Gandhi, Siddhesh Rajan; Schafer, James; Singh, Tushar; Puleo, Elaine; Mullett, Gary; Wilson, Carole

2011-01-01

In order to enhance the perception of indoor and unfamiliar environments for the blind and visually-impaired, we introduce the PERCEPT system that supports a number of unique features such as: a) Low deployment and maintenance cost; b) Scalability, i.e. we can deploy the system in very large buildings; c) An on-demand system that does not overwhelm the user, as it offers small amounts of information on demand; and d) Portability and ease-of-use, i.e., the custom handheld device carried by the user is compact and instructions are received audibly.

Effects of surface properties on droplet formation inside a microfluidic device

NASA Astrophysics Data System (ADS)

Steinhaus, Ben; Shen, Amy

2004-11-01

Micro-fluidic devices offer a unique method of creating and controlling droplets on small length scales. A microfluidic device is used to study the effects of surface properties on droplet formation of a 2-phase flow system. Four phase diagrams are generated to compare the dynamics of the 2 immiscible fluid system (silicone oil and water) inside microchannels with different surface properties. Results show that the channel surface plays an important role in determining the flow patterns and the droplet formation of the 2-phase fluid system.

Professionalism, bureaucracy and patriotism: the VA as a health care megasystem.

PubMed

Rosenheck, R

The Veterans Administration supports the largest integrated psychiatry service in the country. As our oldest and largest "megasystem," this service offers a unique opportunity for examining distinctive features of such large health care delivery systems. Characteristic experiences of mental health professionals in this system are described and the system is analyzed in terms of its organizational tasks, structure and cultures. Psychiatry will be practiced, in the future, in similarly large scale organizations. Understanding the nature and workings of such organizations is likely to become essential to effective and satisfying professional work.

Exploring Propulsion System Requirements for More and All-Electric Helicopters

NASA Technical Reports Server (NTRS)

Snyder, Christopher A.

2015-01-01

Helicopters offer unique capabilities that are important for certain missions. More and all-electric propulsion systems for helicopters offer the potential for improved efficiency, reliability, vehicle and mission capabilities as well as reduced harmful emissions. To achieve these propulsion system-based benefits, the relevant requirements must be understood and developed for the various component, sub-component and ancillary systems of the overall propulsion system. Three representative helicopters were used to explore propulsion and overall vehicle and mission requirements. These vehicles varied from light utility (one to three occupants) to highly capable (three crew members plus ten passengers and cargo). Assuming 15 and 30 year technology availability, analytical models for electric system components were developed to understand component and ancillary requirements. Overall propulsion system characteristics were developed and used for vehicle sizing and mission analyses to understand the tradeoffs of component performance and weight, with increase in vehicle size and mission capability. Study results indicate that only the light utility vehicle retained significant payload for an arbitrary 100 nautical mile range assuming 15 year technology. Thirty year technology assumptions for battery energy storage are sufficient to enable some range and payload capabilities, but further improvements in energy density are required to maintain or exceed payload and range capabilities versus present systems. Hydrocarbon-fueled range extenders can be prudently used to recover range and payload deficiencies resulting from battery energy density limitations. Thermal loads for electric systems are low heat quality, but seem manageable. To realize the benefits from more and all-electric systems, technology goals must be achieved, as well as vehicles, missions and systems identified that are best suited to take advantage of their unique characteristics.

Exploring Propulsion System Requirements for More and All-Electric Helicopters

NASA Technical Reports Server (NTRS)

Snyder, Christopher A.

2015-01-01

Helicopters offer unique capabilities that are important for certain missions. More and all-electric propulsion systems for helicopters offer the potential for improved efficiency, reliability, vehicle and mission capabilities as well as reduced harmful emissions. To achieve these propulsion system-based benefits, the relevant requirements must be understood and developed for the various component, sub-component and ancillary systems of the overall propulsion system. Three representative helicopters were used to explore propulsion and overall vehicle and mission requirements. These vehicles varied from light utility (one to three occupants) to highly capable (three crew members plus ten passengers and cargo). Assuming 15 and 30 year technology availability, analytical models for electric system components were developed to understand component and ancillary requirements. Overall propulsion system characteristics were developed and used for vehicle sizing and mission analyses to understand the tradeoffs of component performance and weight, with increase in vehicle size and mission capability. Study results indicate that only the light utility vehicle retained significant payload for an arbitrary 100 nautical mile range assuming 15 year technology. Thirty year technology assumptions for battery energy storage are sufficient to enable some range and payload capabilities, but further improvements in energy density are required to maintain or exceed payload and range capabilities versus present systems. Hydrocarbon-fueled range extenders can be prudently used to recover range and payload deficiencies resulting from battery energy density limitations. Thermal loads for electric systems are low heat quality, but seem manageable. To realize the benefits from more and all-electric systems, technology goals must be achieved, as well as identify vehicles, missions and systems that are best suited to take advantage of their unique characteristics.

Improved Design of Optical MEMS Using the SUMMiT Fabrication Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michalicek, M.A.; Comtois, J.H.; Barron, C.C.

This paper describes the design and fabrication of optical Microelectromechanical Systems (MEMS) devices using the Sandia Ultra planar Multilevel MEMS Technology (SUMMiT) fabrication process. This state of the art process, offered by Sandia National Laboratories, provides unique and very advantageous features which make it ideal for optical devices. This enabling process permits the development of micromirror devices with near ideal characteristics which have previously been unrealizable in standard polysilicon processes. This paper describes such characteristics as elevated address electrodes, individual address wiring beneath the device, planarized mirror surfaces, unique post-process metallization, and the best active surface area to date.

Investing in sustainability at Coral World

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, O.

Now open and operational for several years, Coral World offers a unique environmental model for other tourism-related facilities throughout the Caribbean and beyond. The extensive energy conservation program has yielded a 40 to 50% reduction in energy use and costs. The facility's unique on-site storm water absorption system virtually eliminates silt runoff to the coastal waters. The innovative, highly cost-effective series of renewable energy installations include a photovoltaic-powered restaurant kitchen, solar hot water systems and one of the world's first hydroelectric systems that uses wastewater drainage for turbine source waters. The extensive marine environmental conservation program protects fragile local ecosystemsmore » while also protecting the owners' investment in tourism. By investing aggressively in sustainability, Coral World's owners are reaping the benefits not only in reduced operating costs and improved profitability, but also in increased visitor volume and satisfaction.« less

The value of price transparency in residential solar photovoltaic markets

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Shaughnessy, Eric; Margolis, Robert

Installed prices for residential solar photovoltaic (PV) systems have declined significantly in recent years. However price dispersion and limited customer access to PV quotes prevents some prospective customers from obtaining low price offers. This study shows that improved customer access to prices - also known as price transparency - is a potential policy lever for further PV price reductions. We use customer search and strategic pricing theory to show that PV installation companies face incentives to offer lower prices in markets with more price transparency. We test this theoretical framework using a unique residential PV quote dataset. Our results showmore » that installers offer lower prices to customers that are expected to receive more quotes. Our study provides a rationale for policies to improve price transparency in residential PV markets.« less

The value of price transparency in residential solar photovoltaic markets

DOE PAGES

O'Shaughnessy, Eric; Margolis, Robert

2018-04-05

Installed prices for residential solar photovoltaic (PV) systems have declined significantly in recent years. However price dispersion and limited customer access to PV quotes prevents some prospective customers from obtaining low price offers. This study shows that improved customer access to prices - also known as price transparency - is a potential policy lever for further PV price reductions. We use customer search and strategic pricing theory to show that PV installation companies face incentives to offer lower prices in markets with more price transparency. We test this theoretical framework using a unique residential PV quote dataset. Our results showmore » that installers offer lower prices to customers that are expected to receive more quotes. Our study provides a rationale for policies to improve price transparency in residential PV markets.« less

Computer-Based Medical System

NASA Technical Reports Server (NTRS)

1998-01-01

SYMED, Inc., developed a unique electronic medical records and information management system. The S2000 Medical Interactive Care System (MICS) incorporates both a comprehensive and interactive medical care support capability and an extensive array of digital medical reference materials in either text or high resolution graphic form. The system was designed, in cooperation with NASA, to improve the effectiveness and efficiency of physician practices. The S2000 is a MS (Microsoft) Windows based software product which combines electronic forms, medical documents, records management, and features a comprehensive medical information system for medical diagnostic support and treatment. SYMED, Inc. offers access to its medical systems to all companies seeking competitive advantages.

Lunar placement of Mars quarantine facility

NASA Technical Reports Server (NTRS)

Davidson, James E.; Mitchell, W. F.

1988-01-01

Advanced mission scenarios are currently being contemplated that would call for the retrieval of surface samples from Mars, from a comet, and from other places in the solar system. An important consideration for all of these sample return missions is quarantine. Quarantine facilities on the Moon offer unique advantages over other locations. The Moon offers gravity, distance, and vacuum. It is sufficiently near the Earth to allow rapid resupply and easy communication. It is sufficiently distant to lessen the psychological impact of a quarantine facility on Earth's human inhabitants. Finally, the Moon is airless, and seems to be devoid of life. It is, therefore, more suited to contamination control efforts.

A Different Description of Trauma: A Wider Systemic Perspective--A Personal Insight

ERIC Educational Resources Information Center

Healey, Arlene

2004-01-01

This special edition of Child Care in Practice provides a unique opportunity to reflect on the years since the signing of the Belfast Agreement in 1998 and the period leading up to this. This article offers my personal views based on my experience of working with families affected by the Troubles. As a family therapist I am trained to view matters…

Bioenergy production systems and biochar application in forests: potential for renewable energy, soil enhancement, and carbon sequestration

Treesearch

Kristin McElligott; Debbie Dumroese; Mark Coleman

2011-01-01

Bioenergy production from forest biomass offers a unique solution to reduce wildfire hazard fuel while producing a useful source of renewable energy. However, biomass removals raise concerns about reducing soil carbon and altering forest site productivity. Biochar additions have been suggested as a way to mitigate soil carbon loss and cycle nutrients back into forestry...

Beyond Watches and Chocolate-Global Mental Health Elective in Switzerland.

PubMed

Schneeberger, Andres R; Weiss, Andrea; von Blumenthal, Suzanne; Lang, Undine E; Huber, Christian G; Schwartz, Bruce J

2016-08-01

Despite increasing interest in global mental health training opportunities, only a few psychiatry residency programs offer global mental health training experiences in developing countries and even fewer programs offer it in other first-world countries. The authors developed a global mental health elective giving US psychiatry residents the opportunity to visit Switzerland to study and experience the mental health care system in this European country. This elective focuses on four major learning objectives: (1) the system of training and curriculum of postgraduate psychiatry education in Switzerland, (2) clinical and organizational aspects of Swiss mental health, (3) administrative aspects of Swiss mental health care delivery, and (4) scholarly activity. This program was uniquely tailored for psychiatry residents. The preliminary experiences with US psychiatry residents show that they value this learning experience, the opportunity to access a different mental health care system, as well as the potential to build international connections with peers.

A Formal Approach to Requirements-Based Programming

NASA Technical Reports Server (NTRS)

Hinchey, Michael G.; Rash, James L.; Rouff, Christopher A.

2005-01-01

No significant general-purpose method is currently available to mechanically transform system requirements into a provably equivalent model. The widespread use of such a method represents a necessary step toward high-dependability system engineering for numerous application domains. Current tools and methods that start with a formal model of a system and mechanically produce a provably equivalent implementation are valuable but not sufficient. The "gap" unfilled by such tools and methods is that the formal models cannot be proven to be equivalent to the requirements. We offer a method for mechanically transforming requirements into a provably equivalent formal model that can be used as the basis for code generation and other transformations. This method is unique in offering full mathematical tractability while using notations and techniques that are well known and well trusted. Finally, we describe further application areas we are investigating for use of the approach.

NASA Earth Observation Systems and Applications for Public Health and Air Quality Models and Decisions Support

NASA Technical Reports Server (NTRS)

Estes, Sue; Haynes, John; Omar, Ali

2013-01-01

Health and Air Quality providers and researchers need environmental data to study and understand the geographic, environmental, and meteorological differences in disease. Satellite remote sensing of the environment offers a unique vantage point that can fill in the gaps of environmental, spatial, and temporal data for tracking disease. This presentation will demonstrate the need for collaborations between multi-disciplinary research groups to develop the full potential of utilizing Earth Observations in studying health. Satellite earth observations present a unique vantage point of the earth's environment from space, which offers a wealth of health applications for the imaginative investigator. The presentation is directly related to Earth Observing systems and Global Health Surveillance and will present research results of the remote sensing environmental observations of earth and health applications, which can contribute to the public health and air quality research. As part of NASA approach and methodology they have used Earth Observation Systems and Applications for Public Health and Air Quality Models to provide a method for bridging gaps of environmental, spatial, and temporal data for tracking disease. This presentation will provide an overview of projects dealing with infectious diseases, water borne diseases and air quality and how many environmental variables effect human health. This presentation will provide a venue where the results of both research and practice using satellite earth observations to study weather and it's role in public health research.

NASA Earth Observation Systems and Applications for Public Health and Air Quality Models and Decisions Support

NASA Technical Reports Server (NTRS)

Estes, Sue; Haynes, John; Omar, Ali

2012-01-01

Health and Air Quality providers and researchers need environmental data to study and understand the geographic, environmental, and meteorological differences in disease. Satellite remote sensing of the environment offers a unique vantage point that can fill in the gaps of environmental, spatial, and temporal data for tracking disease. This presentation will demonstrate the need for collaborations between multi-disciplinary research groups to develop the full potential of utilizing Earth Observations in studying health. Satellite earth observations present a unique vantage point of the earth's environment from space, which offers a wealth of health applications for the imaginative investigator. The presentation is directly related to Earth Observing systems and Global Health Surveillance and will present research results of the remote sensing environmental observations of earth and health applications, which can contribute to the public health and air quality research. As part of NASA approach and methodology they have used Earth Observation Systems and Applications for Public Health and Air Quality Models to provide a method for bridging gaps of environmental, spatial, and temporal data for tracking disease. This presentation will provide an overview of projects dealing with infectious diseases, water borne diseases and air quality and how many environmental variables effect human health. This presentation will provide a venue where the results of both research and practice using satellite earth observations to study weather and it's role in public health research.

101 Ways To Build Enrollment in Your Early Childhood Program.

ERIC Educational Resources Information Center

Montanari, Ellen Orton

Written for administrators of early childhood program centers, this book offers tips on how to increase enrollment. The book offers suggestions rather than a theoretical overview or a comprehensive marketing strategy. Suggestions offered include: (1) Offer a quality program; (2) be aware of your target market; (3) make your program unique; (4)…

Engineering Biomaterial Properties for Central Nervous System Applications

NASA Astrophysics Data System (ADS)

Rivet, Christopher John

Biomaterials offer unique properties that are intrinsic to the chemistry of the material itself or occur as a result of the fabrication process; iron oxide nanoparticles are superparamagnetic, which enables controlled heating in the presence of an alternating magnetic field, and a hydrogel and electrospun fiber hybrid material provides minimally invasive placement of a fibrous, artificial extracellular matrix for tissue regeneration. Utilization of these unique properties towards central nervous system disease and dysfunction requires a thorough definition of the properties in concert with full biological assessment. This enables development of material-specific features to elicit unique cellular responses. Iron oxide nanoparticles are first investigated for material-dependent, cortical neuron cytotoxicity in vitro and subsequently evaluated for alternating magnetic field stimulation induced hyperthermia, emulating the clinical application for enhanced chemotherapy efficacy in glioblastoma treatment. A hydrogel and electrospun fiber hybrid material is first applied to a rat brain to evaluate biomaterial interface astrocyte accumulation as a function of hybrid material composition. The hybrid material is then utilized towards increasing functional engraftment of dopaminergic progenitor neural stem cells in a mouse model of Parkinson's disease. Taken together, these two scenarios display the role of material property characterization in development of biomaterial strategies for central nervous system repair and regeneration.

Silicon photonics for high-performance interconnection networks

NASA Astrophysics Data System (ADS)

Biberman, Aleksandr

2011-12-01

We assert in the course of this work that silicon photonics has the potential to be a key disruptive technology in computing and communication industries. The enduring pursuit of performance gains in computing, combined with stringent power constraints, has fostered the ever-growing computational parallelism associated with chip multiprocessors, memory systems, high-performance computing systems, and data centers. Sustaining these parallelism growths introduces unique challenges for on- and off-chip communications, shifting the focus toward novel and fundamentally different communication approaches. This work showcases that chip-scale photonic interconnection networks, enabled by high-performance silicon photonic devices, enable unprecedented bandwidth scalability with reduced power consumption. We demonstrate that the silicon photonic platforms have already produced all the high-performance photonic devices required to realize these types of networks. Through extensive empirical characterization in much of this work, we demonstrate such feasibility of waveguides, modulators, switches, and photodetectors. We also demonstrate systems that simultaneously combine many functionalities to achieve more complex building blocks. Furthermore, we leverage the unique properties of available silicon photonic materials to create novel silicon photonic devices, subsystems, network topologies, and architectures to enable unprecedented performance of these photonic interconnection networks and computing systems. We show that the advantages of photonic interconnection networks extend far beyond the chip, offering advanced communication environments for memory systems, high-performance computing systems, and data centers. Furthermore, we explore the immense potential of all-optical functionalities implemented using parametric processing in the silicon platform, demonstrating unique methods that have the ability to revolutionize computation and communication. Silicon photonics enables new sets of opportunities that we can leverage for performance gains, as well as new sets of challenges that we must solve. Leveraging its inherent compatibility with standard fabrication techniques of the semiconductor industry, combined with its capability of dense integration with advanced microelectronics, silicon photonics also offers a clear path toward commercialization through low-cost mass-volume production. Combining empirical validations of feasibility, demonstrations of massive performance gains in large-scale systems, and the potential for commercial penetration of silicon photonics, the impact of this work will become evident in the many decades that follow.

Challenges in verification and validation of autonomous systems for space exploration

NASA Technical Reports Server (NTRS)

Brat, Guillaume; Jonsson, Ari

2005-01-01

Space exploration applications offer a unique opportunity for the development and deployment of autonomous systems, due to limited communications, large distances, and great expense of direct operation. At the same time, the risk and cost of space missions leads to reluctance to taking on new, complex and difficult-to-understand technology. A key issue in addressing these concerns is the validation of autonomous systems. In recent years, higher-level autonomous systems have been applied in space applications. In this presentation, we will highlight those autonomous systems, and discuss issues in validating these systems. We will then look to future demands on validating autonomous systems for space, identify promising technologies and open issues.

Mechanical and Electronic Approaches to Improve the Sensitivity of Microcantilever Sensors

PubMed Central

Mutyala, Madhu Santosh Ku; Bandhanadham, Deepika; Pan, Liu; Pendyala, Vijaya Rohini; Ji, Hai-Feng

2010-01-01

Advances in the field of Micro Electro Mechanical Systems (MEMS) and their uses now offer unique opportunities in the design of ultrasensitive analytical tools. The analytical community continues to search for cost-effective, reliable, and even portable analytical techniques that can give reliable and fast response results for a variety of chemicals and biomolecules. Microcantilevers (MCLs) have emerged as a unique platform for label-free biosensor or bioassay. Several electronic designs, including piezoresistive, piezoelectric, and capacitive approaches, have been applied to measure the bending or frequency change of the MCLs upon exposure to chemicals. This review summarizes mechanical, fabrication, and electronics approaches to increase the sensitivity of microcantilever (MCL) sensors. PMID:20975987

Comparative Evaluation of Recombinant Protein Production in Different Biofactories: The Green Perspective

PubMed Central

Capaldi, Stefano

2014-01-01

In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity of platforms based on plants offers a significant advantage. Here, we discuss the production of four recombinant pharmaceutical proteins using different platforms, highlighting from these examples the unique advantages of plant-based systems over traditional fermenter-based expression platforms. PMID:24745008

An Open Architecture for Defense Virtual Environment Training Systems

DTIC Science & Technology

2003-09-01

Additionally, in the process, preventing the loss of life is also an important result. VRTEs can provide needed training that might otherwise not be...training is directly valuable in mission accomplishment and in preventing loss of life. "One of the biggest problems in both the military and...simplified; unique bones motion offers lifelike bouncing and twisting. 43 o Complete skeletal and muscle control features. o Inverse Kinematics

The Center for Health Care Law: the legal muscle of home care and hospice.

PubMed

Dombi, Bill

2006-10-01

The Center for Health Care Law is a unique offering for a trade association. Operating as a law firm within NAHC, the Center has strengthened NAHC's advocacy efforts on all fronts. The law provides a useful structure and a rational system for behavior, provided that the law is understood. The Center brings the necessary understanding of the law to home care and hospice.

Fast Transients: Closing the Loop on Air Force Professional Military Education

DTIC Science & Technology

2013-02-19

esprit de corps, and offer experiential leadership opportunities unique to the military.5 Since Colonel Ritchey’s inception, technological advances have...the technology that delivers it, and while PME students and instructors will be geographically separated, it is important to note that the... technology of distance learning should not replace the instructor. Hence, any PME distance learning courseware must be more than a fire-and-forget system. As

Hazards in the theater.

PubMed

Rossol, M; Hinkamp, D

2001-01-01

The authors offer a survey of the myriad and unique safety and health hazards faced past and present by performers and theatrical workers, from preproduction work, through the show, and during the strike (dismantling). Special emphasis is given to health hazards posed by the many new plastic resin systems and adhesives used in set, prop, and costume construction; the hazards of special-effect fogs, smokes, haze, dusts, and pyrotechnic emissions; and theatrical makeup.

Implementing an Electronic Medical Record in a Family Medicine Practice: Communication, Decision Making, and Conflict

PubMed Central

Crosson, Jesse C.; Stroebel, Christine; Scott, John G.; Stello, Brian; Crabtree, Benjamin F.

2005-01-01

PURPOSE Electronic medical record (EMR) systems offer substantial opportunities to organize and manage clinical data in ways that can potentially improve preventive health care, the management of chronic illness, and the financial health of primary care practices. The functionality of EMRs as implemented, however, can vary substantially from that envisaged by their designers and even from those who purchase the programs. The purpose of this study was to explore how unique aspects of a family medicine office culture affect the initial implementation of an EMR. METHODS As part of a larger study, we conducted a qualitative case study of a private family medicine practice that had recently purchased and implemented an EMR. We collected data using participant observation, in-depth interviews, and key informant interviews. After the initial data collection, we shared our observations with practice members and returned 1 year later to collect additional data. RESULTS Dysfunctional communication patterns, the distribution of formal and informal decision-making power, and internal conflicts limited the effective implementation and use of the EMR. The implementation and use of the EMR made tracking and monitoring of preventive health and chronic illness unwieldy and offered little or no improvement when compared with paper charts. CONCLUSIONS Implementing an EMR without an understanding of the systemic effects and communication and the decision-making processes within an office practice and without methods for bringing to the surface and addressing conflicts limits the opportunities for improved care offered by EMRs. Understanding how these common issues manifest within unique practice settings can enhance the effective implementation and use of EMRs. PMID:16046562

Implementing an electronic medical record in a family medicine practice: communication, decision making, and conflict.

PubMed

Crosson, Jesse C; Stroebel, Christine; Scott, John G; Stello, Brian; Crabtree, Benjamin F

2005-01-01

Electronic medical record (EMR) systems offer substantial opportunities to organize and manage clinical data in ways that can potentially improve preventive health care, the management of chronic illness, and the financial health of primary care practices. The functionality of EMRs as implemented, however, can vary substantially from that envisaged by their designers and even from those who purchase the programs. The purpose of this study was to explore how unique aspects of a family medicine office culture affect the initial implementation of an EMR. As part of a larger study, we conducted a qualitative case study of a private family medicine practice that had recently purchased and implemented an EMR. We collected data using participant observation, in-depth interviews, and key informant interviews. After the initial data collection, we shared our observations with practice members and returned 1 year later to collect additional data. Dysfunctional communication patterns, the distribution of formal and informal decision-making power, and internal conflicts limited the effective implementation and use of the EMR. The implementation and use of the EMR made tracking and monitoring of preventive health and chronic illness unwieldy and offered little or no improvement when compared with paper charts. Implementing an EMR without an understanding of the systemic effects and communication and the decision-making processes within an office practice and without methods for bringing to the surface and addressing conflicts limits the opportunities for improved care offered by EMRs. Understanding how these common issues manifest within unique practice settings can enhance the effective implementation and use of EMRs.

On the Materials Science of Nature's Arms Race.

PubMed

Liu, Zengqian; Zhang, Zhefeng; Ritchie, Robert O

2018-06-05

Biological material systems have evolved unique combinations of mechanical properties to fulfill their specific function through a series of ingenious designs. Seeking lessons from Nature by replicating the underlying principles of such biological materials offers new promise for creating unique combinations of properties in man-made systems. One case in point is Nature's means of attack and defense. During the long-term evolutionary "arms race," naturally evolved weapons have achieved exceptional mechanical efficiency with a synergy of effective offense and persistence-two characteristics that often tend to be mutually exclusive in many synthetic systems-which may present a notable source of new materials science knowledge and inspiration. This review categorizes Nature's weapons into ten distinct groups, and discusses the unique structural and mechanical designs of each group by taking representative systems as examples. The approach described is to extract the common principles underlying such designs that could be translated into man-made materials. Further, recent advances in replicating the design principles of natural weapons at differing lengthscales in artificial materials, devices and tools to tackle practical problems are revisited, and the challenges associated with biological and bioinspired materials research in terms of both processing and properties are discussed. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The International Space Station: A Unique Platform For Terrestrial Remote Sensing

NASA Technical Reports Server (NTRS)

Stefanov, William L.; Evans, Cynthia A.

2012-01-01

The International Space Station (ISS) became operational in November of 2000, and until recently remote sensing activities and operations have focused on handheld astronaut photography of the Earth. This effort builds from earlier NASA and Russian space programs (e.g. Evans et al. 2000; Glazovskiy and Dessinov 2000). To date, astronauts have taken more than 600,000 images of the Earth s land surface, oceans, and atmospheric phenomena from orbit using film and digital cameras as part two payloads: NASA s Crew Earth Observations experiment (http://eol.jsc.nasa.gov/) and Russia s Uragan experiment (Stefanov et al. 2012). Many of these images have unique attributes - varying look angles, ground resolutions, and illumination - that are not available from other remote sensing platforms. Despite this large volume of imagery and clear capability for Earth remote sensing, the ISS historically has not been perceived as an Earth observations platform by many remote sensing scientists. With the recent installation of new facilities and sophisticated sensor systems, and additional systems manifested and in development, that perception is changing to take advantage of the unique capabilities and viewing opportunities offered by the ISS.

Advanced materials for space nuclear power systems

NASA Technical Reports Server (NTRS)

Titran, Robert H.; Grobstein, Toni L.; Ellis, David L.

1991-01-01

The overall philosophy of the research was to develop and characterize new high temperature power conversion and radiator materials and to provide spacecraft designers with material selection options and design information. Research on three candidate materials (carbide strengthened niobium alloy PWC-11 for fuel cladding, graphite fiber reinforced copper matrix composites for heat rejection fins, and tungsten fiber reinforced niobium matrix composites for fuel containment and structural supports considered for space power system applications is discussed. Each of these types of materials offers unique advantages for space power applications.

Explosive Welding in the 1990's

NASA Technical Reports Server (NTRS)

Lalwaney, N. S.; Linse, V. D.

1985-01-01

Explosive bonding is a unique joining process with the serious potential to produce composite materials capable of fulfilling many of the high performance materials capable of fulfilling many of the high performance materials needs of the 1990's. The process has the technological versatility to provide a true high quality metallurgical compatible and incompatible systems. Metals routinely explosively bonded include a wide variety of combinations of reactive and refractory metals, low and high density metals and their alloys, corrosion resistant and high strength alloys, and common steels. The major advantage of the process is its ability to custom design and engineer composites with physical and/or mechanical properties that meet a specific or unusual performance requirement. Explosive bonding offers the designer unique opportunities in materials selection with unique combinations of properties and high integrity bonds that cannot be achieved by any other metal joining process. The process and some applications are discussed.

The avian respiratory system: a unique model for studies of respiratory toxicosis and for monitoring air quality.

PubMed Central

Brown, R E; Brain, J D; Wang, N

1997-01-01

There are many distinct differences (morphologic, physiologic, and mechanical) between the bird's lung-air-sac respiratory system and the mammalian bronchoalveolar lung. In this paper, we review the physiology of the avian respiratory system with attention to those mechanisms that may lead to significantly different results, relative to those in mammals, following exposure to toxic gases and airborne particulates. We suggest that these differences can be productively exploited to further our understanding of the basic mechanisms of inhalant toxicology (gases and particulates). The large mass-specific gas uptake by the avian respiratory system, at rest and especially during exercise, could be exploited as a sensitive monitor of air quality. Birds have much to offer in our understanding of respiratory toxicology, but that expectation can only be realized by investigating, in a wide variety of avian taxa, the pathophysiologic interactions of a broad range of inhaled toxicants on the bird's unique respiratory system. Images p188-a Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. A Figure 5. B Figure 5. C Figure 6. Figure 7. Figure 8. PMID:9105794

Dynamics of primary and secondary microbubbles created by laser-induced breakdown of an optically trapped nanoparticle

PubMed Central

Arita, Y.; Antkowiak, M.; Venugopalan, V.; Gunn-Moore, F. J.; Dholakia, K.

2012-01-01

Laser-induced breakdown of an optically trapped nanoparticle is a unique system for studying cavitation dynamics. It offers additional degrees of freedom, namely the nanoparticle material, its size, and the relative position between the laser focus and the center of the optically trapped nanoparticle. We quantify the spatial and temporal dynamics of the cavitation and secondary bubbles created in this system and use hydrodynamic modeling to quantify the observed dynamic shear stress of the expanding bubble. In the final stage of bubble collapse, we visualize the formation of multiple submicrometer secondary bubbles around the toroidal bubble on the substrate. We show that the pattern of the secondary bubbles typically has its circular symmetry broken along an axis whose unique angle rotates over time. This is a result of vorticity along the jet towards the boundary upon bubble collapse near solid boundaries. PMID:22400669

Characterization of individual mouse cerebrospinal fluid proteomes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Jeffrey S.; Angel, Thomas E.; Chavkin, Charles

2014-03-20

Analysis of cerebrospinal fluid (CSF) offers key insight into the status of the central nervous system. Characterization of murine CSF proteomes can provide a valuable resource for studying central nervous system injury and disease in animal models. However, the small volume of CSF in mice has thus far limited individual mouse proteome characterization. Through non-terminal CSF extractions in C57Bl/6 mice and high-resolution liquid chromatography-mass spectrometry analysis of individual murine samples, we report the most comprehensive proteome characterization of individual murine CSF to date. Utilizing stringent protein inclusion criteria that required the identification of at least two unique peptides (1% falsemore » discovery rate at the peptide level) we identified a total of 566 unique proteins, including 128 proteins from three individual CSF samples that have been previously identified in brain tissue. Our methods and analysis provide a mechanism for individual murine CSF proteome analysis.« less

Dissecting polyclonal vaccine-induced humoral immunity against HIV using Systems Serology

PubMed Central

Chung, Amy W.; Kumar, Manu P.; Arnold, Kelly B.; Yu, Wen Han; Schoen, Matthew K.; Dunphy, Laura J.; Suscovich, Todd J.; Frahm, Nicole; Linde, Caitlyn; Mahan, Alison E.; Hoffner, Michelle; Streeck, Hendrik; Ackerman, Margaret E.; McElrath, M. Juliana; Schuitemaker, Hanneke; Pau, Maria G.; Baden, Lindsey R.; Kim, Jerome H.; Michael, Nelson L.; Barouch, Dan H.; Lauffenburger, Douglas A.; Alter, Galit

2017-01-01

While antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity. As antibodies mediate an array of extra-neutralizing Fc-functions, when neutralization fails to predict protection, investigating Fc-mediated activity may help identify immunological correlates and mechanism(s) of humoral protection. Here, we used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine-trials. Each vaccine regimen induced a unique humoral “Fc-fingerprint”. Moreover, analysis of case:control data from the first moderately protective HIV vaccine trial, RV144, pointed to mechanistic insights into immune complex composition that may underlie protective immunity to HIV. Thus, multi-dimensional relational comparisons of vaccine humoral fingerprints offer a unique approach for the evaluation and design of novel vaccines against pathogens for which correlates of protection remain elusive. PMID:26544943

Polysaccharide based nanogels in the drug delivery system: Application as the carrier of pharmaceutical agents.

PubMed

Debele, Tilahun Ayane; Mekuria, Shewaye Lakew; Tsai, Hsieh-Chih

2016-11-01

Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different pharmaceutical agents due to their unique multi-functional groups in addition to their physicochemical properties, including biocompatibility and biodegradability. The existence of multi-functional groups on the polysaccharide backbone permits facile chemical or biochemical modification to synthesize polysaccharide based nanoparticles with miscellaneous structures. Polysaccharide-based nanogels have high water content, large surface area for multivalent bioconjugation, tunable size, and interior network for the incorporation of different pharmaceutical agents. These unique properties offer great potential for the utilization of polysaccharide-based nanogels in the drug delivery systems. Hence, this review describes chemistry of certain common polysaccharides, several methodologies used to synthesize polysaccharide nanoparticles and primarily focused on the polysaccharide (or polysaccharide derivative) based nanogels as the carrier of pharmaceutical agents. Copyright © 2016 Elsevier B.V. All rights reserved.

Monitoring and guidance of HIFU beams with dual-mode ultrasound arrays.

PubMed

Ballard, John R; Casper, Andrew J; Ebbini, Emad S

2009-01-01

We present experimental results illustrating the unique advantages of dual-mode array (DMUA) systems in monitoring and guidance of high intensity focused ultrasound (HIFU) lesion formation. DMUAs offer a unique paradigm in image-guided surgery; one in which images obtained using the same therapeutic transducer provide feedback for: 1) refocusing the array in the presence of strongly scattering objects, e.g. the ribs, 2) temperature change at the intended location of the HIFU focus, and 3) changes in the echogenicity of the tissue in response to therapeutic HIFU. These forms of feedback have been demonstrated in vitro in preparation for the design and implementation of a real-time system for imaging and therapy with DMUAs. The results clearly demonstrate that DMUA image feedback is spatially accurate and provide sufficient spatial and contrast resolution for identification of high contrast objects like the ribs and significant blood vessels in the path of the HIFU beam.

Microfluidic and nanofluidic phase behaviour characterization for industrial CO2, oil and gas.

PubMed

Bao, Bo; Riordon, Jason; Mostowfi, Farshid; Sinton, David

2017-08-08

Microfluidic systems that leverage unique micro-scale phenomena have been developed to provide rapid, accurate and robust analysis, predominantly for biomedical applications. These attributes, in addition to the ability to access high temperatures and pressures, have motivated recent expanded applications in phase measurements relevant to industrial CO 2 , oil and gas applications. We here present a comprehensive review of this exciting new field, separating microfluidic and nanofluidic approaches. Microfluidics is practical, and provides similar phase properties analysis to established bulk methods with advantages in speed, control and sample size. Nanofluidic phase behaviour can deviate from bulk measurements, which is of particular relevance to emerging unconventional oil and gas production from nanoporous shale. In short, microfluidics offers a practical, compelling replacement of current bulk phase measurement systems, whereas nanofluidics is not practical, but uniquely provides insight into phase change phenomena at nanoscales. Challenges, trends and opportunities for phase measurements at both scales are highlighted.

Spatial confinement governs orientational order in patchy particles

NASA Astrophysics Data System (ADS)

Iwashita, Yasutaka; Kimura, Yasuyuki

2016-06-01

Orientational order in condensed matter plays a key role in determining material properties such as ferromagnetism, viscoelasticity or birefringence. We studied purely orientational ordering in closely-packed one-patch colloidal particles confined between flat substrates, where the particles can only rotate and are ordered via the sticky interaction between the patches. For the first time, we experimentally realized a rich variety of mesoscopic patterns through orientational ordering of colloids by controlling patch size and confinement thickness. The combination of experiment and numerical simulation reveals the decisive role of confinement: An ordered state(s) is selected from the (meta)stable options in bulk when it is commensurate with the system geometry and boundary conditions; otherwise, frustration induces a unique order. Our study offers a new means of systematic control over mesoscopic structures via orientational ordering in patchy particles. The system would also possess unique functionalities through the rotational response of the particles to external stimuli.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gann, Gabriel D. Orebi

Solar neutrinos offer a unique opportunity to study the interaction of neutrinos with matter, a sensitive search for potential new physics effects, and a probe of solar structure and solar system formation. This paper describes the broad physics program addressed by solar neutrino studies, presents the current suite of experiments programs, and describes several potential future detectors that could address the open questions in this field. This paper is a summary of a talk presented at the Neutrino 2014 conference in Boston.

Successful Tribal College Student Internship

NASA Astrophysics Data System (ADS)

Nall, J.

2003-12-01

The North Dakota Association of Tribal Colleges (NDATC) would like to host a student panel for the AGU community in order to convey the ingredients of a successful student internship program from the tribal student view. Tribal college students offer a unique perspective to the study and utilization of Earth systems science, and we would be prepared to help others in the community build successful interactions and recruitment strategies as they build their partnerships into Native America.

Career Design Education by Cooperation and Collaboration

NASA Astrophysics Data System (ADS)

Takahashi, Takeo; Koma, Tetsuya; Akiyama, Akira; Kihara, Hitoshi; Yamada, Hirofumi

Kanazawa Technical College (KTC) was established to train beginner engineering students in 1962. Since then, KTC offers a unique education/hands on, and has maintained a 100% employment rate upon graduation. In the fourth grade, students participate in a unique industrial internship program for two weeks during summer vacation. As a result, students’ overall satisfaction rate concerning their education is high. Therefore, instead of offering traditional courses that value the experience of the present, it is necessary to offer a new course that lets student discover for themselves what their future will be like. In this paper, an outline of the career design education executed by the students together with their parent (s) /guardian, the school and industry is described.

'Genipin' - the natural water soluble cross-linking agent and its importance in the modified drug delivery systems: an overview.

PubMed

Manickam, Balamurugan; Sreedharan, Rajesh; Elumalai, Manogaran

2014-01-01

One of the popular approaches in controlling drug delivery from the polymeric carriers is suitably achieved by the inclusion of crosslinking agents into the formulations at different concentrations. Nevertheless, addition of the chemical crosslinkers such as glutaraldehyde, formaldehyde etc, used in the drug delivery systems causes very serious cytotoxic reactions. These chemical crosslinking agents did not offer any significant advantageous effects when compared to the natural crosslinking agents for instance genipin, which is quite less toxic, biocompatible and offers very stable crosslinked products. Based on the earlier reports the safety of this particular natural crosslinker is very well established, since it has been widely used as a Chinese traditional medicine for long-time, isolated from fruits of the plant Gardenia jasminoides Ellis. This concise article largely portrayed the value of this unique natural crosslinker, utilized in controlling the drug delivery from the various formulations.

Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.

PubMed

Galán, Jorge E

2016-06-07

Salmonella Typhi is the cause of typhoid fever, a disease that has challenged humans throughout history and continues to be a major public health concern. Unlike infections with most other Salmonellae, which result in self-limiting gastroenteritis, typhoid fever is a life-threatening systemic disease. Furthermore, in contrast to most Salmonellae, which can infect a broad range of hosts, S. Typhi is a strict human pathogen. The unique features of S. Typhi pathogenesis and its stringent host specificity have been a long-standing puzzle. The discovery of typhoid toxin not only has provided major insight into these questions but also has offered unique opportunities to develop novel therapeutic and prevention strategies to combat typhoid fever.

Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi

PubMed Central

Galán, Jorge E.

2016-01-01

Salmonella Typhi is the cause of typhoid fever, a disease that has challenged humans throughout history and continues to be a major public health concern. Unlike infections with most other Salmonellae, which result in self-limiting gastroenteritis, typhoid fever is a life-threatening systemic disease. Furthermore, in contrast to most Salmonellae, which can infect a broad range of hosts, S. Typhi is a strict human pathogen. The unique features of S. Typhi pathogenesis and its stringent host specificity have been a long-standing puzzle. The discovery of typhoid toxin not only has provided major insight into these questions but also has offered unique opportunities to develop novel therapeutic and prevention strategies to combat typhoid fever. PMID:27222578

Fiber optic multiplexed optical transmission systems for space vehicle launch facilities

NASA Technical Reports Server (NTRS)

Bell, C. H.

1975-01-01

Low loss Fiber Optic Cable is being evaluated as a potential future replacement for Kennedy Space Center's 13,000 mile Wideband cable system. In order to make economical use of the wide bandwidth characteristic of glass fibers, a Frequency Division Multiplexing (FDM) scheme has been devised to stack many analog and digital data channels on a single fiber. The Multiplexed Optical Transmission System (MOTS) will offer a unique flexibility of plug-in modularity to meet changing data and bandwidth requirements in addition to the standard 'goodies' of immunity to lightning and other EMI, RFI type interferences, and of smaller size and lighter weight.

High-temperature superconductivity for avionic electronic warfare and radar systems

NASA Astrophysics Data System (ADS)

Ryan, Paul A.

1994-01-01

The electronic warfare (EW) and radar communities expect to be major beneficiaries of the performance advantages high-temperature superconductivity (HTS) has to offer over conventional technology. Near term upgrades to system hardware can be envisioned using extremely small, high Q, microwave filters and resonators; compact, wideband, low loss, microwave delay and transmission lines; as well as, wideband, low loss, monolithic microwave integrated circuit phase shifters. The most dramatic impact will be in the far term, using HTS to develop new, real time threat identification and response strategy receiver/processing systems designed to utilize the unique high frequency properties of microwave and ultimately digital HTS.

Col-OSSOS: Colors of the Interstellar Planetesimal 1I/‘Oumuamua

NASA Astrophysics Data System (ADS)

Bannister, Michele T.; Schwamb, Megan E.; Fraser, Wesley C.; Marsset, Michael; Fitzsimmons, Alan; Benecchi, Susan D.; Lacerda, Pedro; Pike, Rosemary E.; Kavelaars, J. J.; Smith, Adam B.; Stewart, Sunny O.; Wang, Shiang-Yu; Lehner, Matthew J.

2017-12-01

The recent discovery by Pan-STARRS1 of 1I/2017 U1 (‘Oumuamua), on an unbound and hyperbolic orbit, offers a rare opportunity to explore the planetary formation processes of other stars and the effect of the interstellar environment on a planetesimal surface. 1I/‘Oumuamua’s close encounter with the inner solar system in 2017 October was a unique chance to make observations matching those used to characterize the small-body populations of our own solar system. We present near-simultaneous g‧, r‧, and J photometry and colors of 1I/‘Oumuamua from the 8.1 m Frederick C. Gillett Gemini-North Telescope and gri photometry from the 4.2 m William Herschel Telescope. Our g‧r‧J observations are directly comparable to those from the high-precision Colours of the Outer Solar System Origins Survey (Col-OSSOS), which offer unique diagnostic information for distinguishing between outer solar system surfaces. The J-band data also provide the highest signal-to-noise measurements made of 1I/‘Oumuamua in the near-infrared. Substantial, correlated near-infrared and optical variability is present, with the same trend in both near-infrared and optical. Our observations are consistent with 1I/‘Oumuamua rotating with a double-peaked period of 8.10 ± 0.42 hr and being a highly elongated body with an axial ratio of at least 5.3:1, implying that it has significant internal cohesion. The color of the first interstellar planetesimal is at the neutral end of the range of solar system g ‑ r and r ‑ J solar-reflectance colors: it is like that of some dynamically excited objects in the Kuiper Belt and the less-red Jupiter Trojans.

A sustainable primary care system: lessons from the Netherlands.

PubMed

Faber, Marjan J; Burgers, Jako S; Westert, Gert P

2012-01-01

The Dutch primary care system has drawn international attention, because of its high performance at low cost. Primary care practices are easily accessible during office hours and collaborate in a unique out-of-hours system. After the reforms in 2006, there are no copayments for patients receiving care in the primary care practice in which they are registered. Financial incentives support the transfer of care from hospital specialists to primary care physicians, and task delegation from primary care physicians to practice nurses. Regional collaborative care groups of primary care practices offer disease management programs. The quality assessment system and the electronic medical record system are predominantly driven by health care professionals. Bottom-up and top-down activities contributed to a successful Dutch primary care system.

Space Station tethered waste disposal

NASA Technical Reports Server (NTRS)

Rupp, Charles C.

1988-01-01

The Shuttle Transportation System (STS) launches more payload to the Space Station than can be returned creating an accumulation of waste. Several methods of deorbiting the waste are compared including an OMV, solid rocket motors, and a tether system. The use of tethers is shown to offer the unique potential of having a net savings in STS launch requirement. Tether technology is being developed which can satisfy the deorbit requirements but additional effort is required in waste processing, packaging, and container design. The first step in developing this capability is already underway in the Small Expendable Deployer System program. A developmental flight test of a tether initiated recovery system is seen as the second step in the evolution of this capability.

Conflict and Compromise in the Southern Philippines: The Case of Moro Identity.

DTIC Science & Technology

1998-06-01

imbedded in peninsular Malaya, on Java and on Sumatra. Islam was attractive to island leaders as it offered an alternative to the Hindu empire which had...unique not only in that its administrative make-up included a military governorship, but its size and population density also differentiated it from its...school system, administrative set-up, 68 Fowler, 54. 69 T.J.S. George, Revolt in Mindanao: The Rise of Mam in Philippine Politics ( Malaysia : Oxford

Electrochemical hydrogen sulfide biosensors.

PubMed

Xu, Tailin; Scafa, Nikki; Xu, Li-Ping; Zhou, Shufeng; Abdullah Al-Ghanem, Khalid; Mahboob, Shahid; Fugetsu, Bunshi; Zhang, Xueji

2016-02-21

The measurement of sulfide, especially hydrogen sulfide, has held the attention of the analytical community due to its unique physiological and pathophysiological roles in biological systems. Electrochemical detection offers a rapid, highly sensitive, affordable, simple, and real-time technique to measure hydrogen sulfide concentration, which has been a well-documented and reliable method. This review details up-to-date research on the electrochemical detection of hydrogen sulfide (ion selective electrodes, polarographic hydrogen sulfide sensors, etc.) in biological samples for potential therapeutic use.

Advanced supersonic propulsion study, phase 3

NASA Technical Reports Server (NTRS)

Howlett, R. A.; Johnson, J.; Sabatella, J.; Sewall, T.

1976-01-01

The variable stream control engine is determined to be the most promising propulsion system concept for advanced supersonic cruise aircraft. This concept uses variable geometry components and a unique throttle schedule for independent control of two flow streams to provide low jet noise at takeoff and high performance at both subsonic and supersonic cruise. The advanced technology offers a 25% improvement in airplane range and an 8 decibel reduction in takeoff noise, relative to first generation supersonic turbojet engines.

Neutrophil-endothelial cell interactions on endothelial monolayers grown on micropore filters.

PubMed Central

Taylor, R F; Price, T H; Schwartz, S M; Dale, D C

1981-01-01

We have developed a technique for growing endothelial monolayers on micropore filters. These monolayers demonstrate confluence by phase and electron microscopy and provide a functional barrier to passage of radiolabeled albumin. Neutrophils readily penetrate the monolayer in response to chemotaxin, whereas there is little movement in the absence of chemotaxin. This system offers unique advantages over available chemotaxis assays and may have wider applications in the study of endothelial function. Images PMID:7007441

Describing the Elephant: Framing a Discussion on Command and Control

DTIC Science & Technology

2014-08-01

Joint Communications System; and other governing doctrine. The prevalence of C2 in our joint doctrine reflects the centrality of performing C2 well...and the tragedy of doing it poorly (e.g., Operation Eagle Claw during the Iran hostage crisis ; the 1994 Blackhawk shoot-down in Operation Northern...from C2 in the air. By means of its mobility, airborne C2 offers range, reach, and adaptabil- ity—coupled with unique communications and surveillance

Engineers in the mist: The solar in the jungle project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thornton, J.P.; Thornton, S.

This article describes the design and installation of a photovoltaic power supply for a remote orangutan research station in the rain forest in Borneo. The unique needs of the station, including the problems created by noisy equipment and the transport of fuel offering potential for severe damage, are discussed, along with the design of the system, a community based system for the camp that would not only compensate for shadowing loss due to a chain link cage and meet the daily load, but would provide up to 20 days of energy if loads were managed properly.

[The role of nanotechnology in creating novel antitumor agents].

PubMed

Semiglazov, V F; Paltuev, R M; Remizov, A S; Semiglazov, V V; Dashian, G A; Bessonov, A A; Pen'kov, K D; Vasil'ev, A G; Semiglazova, T Iu; Kolar'kova, V V

2011-01-01

Nanobiotechnology, defined as an arm of a nano-system is a rapidly developing area of medicine. Nanomaterials ranging from 1 to 1000 nm in size offer unique advantages of interaction with biological systems on the molecular level. Nanobiotechnologies can be used in definition, diagnosis and treatment of cancer thus leading to the new development of a new discipline--nanooncology. The potential of nanoparticles to be used in in-vivo tumor visualization, biomolecular profiling of tumor growth factors and targeted drug delivery is being studied. These methods stemming from nanotechnology may soon find a broad application in oncology.

Juvenile Justice, Mental Health, and the Transition to Adulthood: A Review of Service System Involvement and Unmet Needs in the U.S

PubMed Central

Zajac, Kristyn; Sheidow, Ashli J.; Davis, Maryann

2015-01-01

Although adolescents are the primary focus of juvenile justice, a significant number of young people involved with this system are considered transition age youth (i.e., 16–25 years of age). The aim of this review is to summarize the specific needs of transition age youth with mental health conditions involved with the juvenile justice system, identify the multiple service systems relevant to this group, and offer recommendations for policies and practice. A comprehensive search strategy was used to identify and synthesize the literature. Findings highlight the paucity of research specific to transition age youth. Thus, we also summarized relevant research on justice-involved adolescents, with a focus evaluating its potential relevance in the context of the unique milestones of the transition age, including finishing one’s education, setting and working towards vocational goals, and transitioning from ones’ family of origin to more independent living situations. Existing programs and initiatives relevant to transition age youth with mental health conditions are highlighted, and nine specific recommendations for policy and practice are offered. PMID:26273119

Juvenile Justice, Mental Health, and the Transition to Adulthood: A Review of Service System Involvement and Unmet Needs in the U.S.

PubMed

Zajac, Kristyn; Sheidow, Ashli J; Davis, Maryann

2015-09-01

Although adolescents are the primary focus of juvenile justice, a significant number of young people involved with this system are considered transition age youth (i.e., 16-25 years of age). The aim of this review is to summarize the specific needs of transition age youth with mental health conditions involved with the juvenile justice system, identify the multiple service systems relevant to this group, and offer recommendations for policies and practice. A comprehensive search strategy was used to identify and synthesize the literature. Findings highlight the paucity of research specific to transition age youth. Thus, we also summarized relevant research on justice-involved adolescents, with a focus evaluating its potential relevance in the context of the unique milestones of the transition age, including finishing one's education, setting and working towards vocational goals, and transitioning from ones' family of origin to more independent living situations. Existing programs and initiatives relevant to transition age youth with mental health conditions are highlighted, and nine specific recommendations for policy and practice are offered.

Privacy-protected biometric templates: acoustic ear identification

NASA Astrophysics Data System (ADS)

Tuyls, Pim T.; Verbitskiy, Evgeny; Ignatenko, Tanya; Schobben, Daniel; Akkermans, Ton H.

2004-08-01

Unique Biometric Identifiers offer a very convenient way for human identification and authentication. In contrast to passwords they have hence the advantage that they can not be forgotten or lost. In order to set-up a biometric identification/authentication system, reference data have to be stored in a central database. As biometric identifiers are unique for a human being, the derived templates comprise unique, sensitive and therefore private information about a person. This is why many people are reluctant to accept a system based on biometric identification. Consequently, the stored templates have to be handled with care and protected against misuse [1, 2, 3, 4, 5, 6]. It is clear that techniques from cryptography can be used to achieve privacy. However, as biometric data are noisy, and cryptographic functions are by construction very sensitive to small changes in their input, and hence one can not apply those crypto techniques straightforwardly. In this paper we show the feasibility of the techniques developed in [5], [6] by applying them to experimental biometric data. As biometric identifier we have choosen the shape of the inner ear-canal, which is obtained by measuring the headphone-to-ear-canal Transfer Functions (HpTFs) which are known to be person dependent [7].

Contributions of identifiable neurons and neuron classes to lamprey vertebrate neurobiology.

PubMed

Buchanan, J T

2001-03-01

Among the advantages offered by the lamprey brainstem and spinal cord for studies of the structure and function of the nervous system is the unique identifiability of several pairs of reticulospinal neurons in the brainstem. These neurons have been exploited in investigations of the patterns of sensory input to these cells and the patterns of their outputs to spinal neurons, but no doubt these cells could be used much more effectively in exploring their roles in descending control of the spinal cord. The variability of cell positions of neurons in the spinal cord has precluded the recognition of unique spinal neurons. However, classes of nerve cells can be readily defined and characterized within the lamprey spinal cord and this has led to progress in understanding the cellular and synaptic mechanisms of locomotor activity. In addition, both the identifiable reticulospinal cells and the various spinal nerve cell classes and their known synaptic interactions have been used to demonstrate the degree and specificity of regeneration within the lamprey nervous system. The lack of uniquely identifiable cells within the lamprey spinal cord has hampered progress in these areas, especially in gaining a full understanding of the locomotor network and how neuromodulation of the network is accomplished.

Optical interconnection networks for high-performance computing systems

NASA Astrophysics Data System (ADS)

Biberman, Aleksandr; Bergman, Keren

2012-04-01

Enabled by silicon photonic technology, optical interconnection networks have the potential to be a key disruptive technology in computing and communication industries. The enduring pursuit of performance gains in computing, combined with stringent power constraints, has fostered the ever-growing computational parallelism associated with chip multiprocessors, memory systems, high-performance computing systems and data centers. Sustaining these parallelism growths introduces unique challenges for on- and off-chip communications, shifting the focus toward novel and fundamentally different communication approaches. Chip-scale photonic interconnection networks, enabled by high-performance silicon photonic devices, offer unprecedented bandwidth scalability with reduced power consumption. We demonstrate that the silicon photonic platforms have already produced all the high-performance photonic devices required to realize these types of networks. Through extensive empirical characterization in much of our work, we demonstrate such feasibility of waveguides, modulators, switches and photodetectors. We also demonstrate systems that simultaneously combine many functionalities to achieve more complex building blocks. We propose novel silicon photonic devices, subsystems, network topologies and architectures to enable unprecedented performance of these photonic interconnection networks. Furthermore, the advantages of photonic interconnection networks extend far beyond the chip, offering advanced communication environments for memory systems, high-performance computing systems, and data centers.

Microfabrication for Drug Delivery

PubMed Central

Koch, Brendan; Rubino, Ilaria; Quan, Fu-Shi; Yoo, Bongyoung; Choi, Hyo-Jick

2016-01-01

This review is devoted to discussing the application of microfabrication technologies to target challenges encountered in life processes by the development of drug delivery systems. Recently, microfabrication has been largely applied to solve health and pharmaceutical science issues. In particular, fabrication methods along with compatible materials have been successfully designed to produce multifunctional, highly effective drug delivery systems. Microfabrication offers unique tools that can tackle problems in this field, such as ease of mass production with high quality control and low cost, complexity of architecture design and a broad range of materials. Presented is an overview of silicon- and polymer-based fabrication methods that are key in the production of microfabricated drug delivery systems. Moreover, the efforts focused on studying the biocompatibility of materials used in microfabrication are analyzed. Finally, this review discusses representative ways microfabrication has been employed to develop systems delivering drugs through the transdermal and oral route, and to improve drug eluting implants. Additionally, microfabricated vaccine delivery systems are presented due to the great impact they can have in obtaining a cold chain-free vaccine, with long-term stability. Microfabrication will continue to offer new, alternative solutions for the development of smart, advanced drug delivery systems. PMID:28773770

Fluorescent Photo-conversion: A second chance to label unique cells.

PubMed

Mellott, Adam J; Shinogle, Heather E; Moore, David S; Detamore, Michael S

2015-03-01

Not all cells behave uniformly after treatment in tissue engineering studies. In fact, some treated cells display no signs of treatment or show unique characteristics not consistent with other treated cells. What if the "unique" cells could be isolated from a treated population, and further studied? Photo-convertible reporter proteins, such as Dendra2 , allow for the ability to selectively identify unique cells with a secondary label within a primary labeled treated population. In the current study, select cells were identified and labeled through photo-conversion of Dendra2 -transfected human Wharton's Jelly cells (hWJCs) for the first time. Robust photo-conversion of green-to-red fluorescence was achieved consistently in arbitrarily selected cells, allowing for precise cell identification of select hWJCs. The current study demonstrates a method that offers investigators the opportunity to selectively label and identify unique cells within a treated population for further study or isolation from the treatment population. Photo-convertible reporter proteins, such as Dendra2 , offer the ability over non-photo-convertible reporter proteins, such as green fluorescent protein, to analyze unique individual cells within a treated population, which allows investigators to gain more meaningful information on how a treatment affects all cells within a target population.

Massachusetts Substance Use Disorder Treatment Organizations’ Perspectives on the Affordable Care Act: Changes in Payment, Services, and System Design

PubMed Central

Quinn, Amity E.; Stewart, Maureen T.; Brolin, Mary; Horgan, Constance; Lane, Nancy E.

2017-01-01

The Affordable Care Act (ACA) expanded insurance benefits and coverage for substance use disorder (SUD) treatment and encouraged delivery and payment reforms. Massachusetts passed a similar reform in 2006. This study aims to assess Massachusetts SUD treatment organizations’ responses to the ACA. Organizational interviews addressing challenges of and responses to the ACA were conducted in-person June–December 2014 with 31 leaders at 12 treatment organizations across Massachusetts. Many organizations were affiliated with medical or social services and offered a range of SUD services. Sampling was based on services offered (detoxification only, detoxification and outpatient, outpatient only). Framework analysis was used. Challenges identified were considered similar to ongoing challenges, not unique to the ACA. Organizations experienced insurance expansions in 2006 and faced new challenges, including insurance coverage, payment arrangements, expansion of services, and system design. System design efforts included care coordination/integration, workforce development, and health information technology. Differences in responses related to connections with medical and social service organizations. Many organizations engaged in efforts to respond to changing policies by expanding capacity and services. Offering a range of SUD treatment (e.g., detoxification and outpatient) and affiliating with a medical organization could enable organizations to respond to new insurance, delivery, and payment reforms. PMID:28350232

Advanced Analgesic Drug Delivery and Nanobiotechnology.

PubMed

Stoicea, Nicoleta; Fiorda-Diaz, Juan; Joseph, Nicholas; Shabsigh, Muhammad; Arias-Morales, Carlos; Gonzalez-Zacarias, Alicia A; Mavarez-Martinez, Ana; Marjoribanks, Stephen; Bergese, Sergio D

2017-07-01

Transdermal administration of analgesic medications offers several benefits over alternative routes of administration, including a decreased systemic drug load with fewer side effects, and avoidance of drug degradation by the gastrointestinal tract. Transdermal administration also offers a convenient mode of drug administration over an extended period of time, particularly desirable in pain medicine. A transdermal administration route may also offer increased safety for drugs with a narrow therapeutic window. The primary barrier to transdermal drug absorption is the skin itself. Transdermal nanotechnology offers a novel method of achieving enhanced dermal penetration with an extended delivery profile for analgesic drugs, due to their small size and relatively large surface area. Several materials have been used to enhance drug duration and transdermal penetration. The application of nanotechnology in transdermal delivery of analgesics has raised new questions regarding safety and ethical issues. The small molecular size of nanoparticles enables drug delivery to previously inaccessible body sites. To ensure safety, the interaction of nanoparticles with the human body requires further investigation on an individual drug basis, since different formulations have unique properties and side effects.

Millimeter-scale MEMS enabled autonomous systems: system feasibility and mobility

NASA Astrophysics Data System (ADS)

Pulskamp, Jeffrey S.

2012-06-01

Millimeter-scale robotic systems based on highly integrated microelectronics and micro-electromechanical systems (MEMS) could offer unique benefits and attributes for small-scale autonomous systems. This extreme scale for robotics will naturally constrain the realizable system capabilities significantly. This paper assesses the feasibility of developing such systems by defining the fundamental design trade spaces between component design variables and system level performance parameters. This permits the development of mobility enabling component technologies within a system relevant context. Feasible ranges of system mass, required aerodynamic power, available battery power, load supported power, flight endurance, and required leg load bearing capability are presented for millimeter-scale platforms. The analysis illustrates the feasibility of developing both flight capable and ground mobile millimeter-scale autonomous systems while highlighting the significant challenges that must be overcome to realize their potential.

Coherent backscattering of singular beams

NASA Astrophysics Data System (ADS)

Schwartz, Chaim; Dogariu, Aristide

2006-02-01

The phenomenon of coherent backscattering depends on both the statistical characteristics of a random scattering medium and the correlation features of the incident field. Imposing a wavefront singularity on the incident field offers a unique and very attractive way to modify the field correlations in a deterministic manner. The field correlations are found to act as a path-length filter which modifies the distribution of different contributions to the enhancement cone. This effect is thoroughly discussed and demonstrated experimentally for the case of single scale scattering systems.

Space migrations: Anthropology and the humanization of space

NASA Technical Reports Server (NTRS)

Finney, Ben R.

1992-01-01

Because of its broad evolutionary perspective and its focus on both technology and culture, anthropology offers a unique view of why we are going into space and what leaving Earth will mean for humanity. In addition, anthropology could help in the humanization of space through (1) overcoming socioculture barriers to working and living in space, (2) designing societies appropriate for permanent space settlement, (3) promoting understanding among differentiated branches of humankind scattered through space, (4) deciphering the cultural systems of any extraterrestrial civilizations contacted.

Everything under the Sun: A review of solar neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gann, Gabriel D. Orebi

2015-07-15

Solar neutrinos offer a unique opportunity to study the interaction of neutrinos with matter, a sensitive search for potential new physics effects, and a probe of solar structure and solar system formation. This paper describes the broad physics program addressed by solar neutrino studies, presents the current suite of experiments programs, and describes several potential future detectors that could address the open questions in this field. This paper is a summary of a talk presented at the Neutrino 2014 conference in Boston.

Elliptic flow in Au+Au collisions at RHIC

NASA Astrophysics Data System (ADS)

Vale, Carla M.; PHOBOS Collaboration; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Decowski, M. P.; García, E.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Heintzelman, G. A.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Holynski, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Katzy, J.; Khan, N.; Kucewicz, W.; Kulinich, P.; Kuo, C. M.; Lin, W. T.; Manly, S.; McLeod, D.; Mignerey, A. C.; Ngyuen, M.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Pernegger, H.; Reed, C.; Remsberg, L. P.; Reuter, M.; Roland, C.; Roland, G.; Rosenberg, L.; Sagerer, J.; Sarin, P.; Sawicki, P.; Skulski, W.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tang, J.-L.; Tonjes, M. B.; Trzupek, A.; van Nieuwenhuizen, G. J.; Verdier, R.; Veres, G.; Wolfs, F. L. H.; Wosiek, B.; Wozniak, K.; Wuosmaa, A. H.; Wyslouch, B.

2005-04-01

Elliptic flow is an interesting probe of the dynamical evolution of the dense system formed in the ultrarelativistic heavy ion collisions at the relativistic heavy ion collider (RHIC). The elliptic flow dependences on transverse momentum, centrality and pseudorapidity were measured using data collected by the PHOBOS detector, which offers a unique opportunity to study the azimuthal anisotropies of charged particles over a wide range of pseudorapidity. These measurements are presented, together with an overview of the analysis methods and a discussion of the results.

Everything under the sun: A review of solar neutrinos

DOE PAGES

Gann, Gabriel D. Orebi

2015-07-15

Solar neutrinos offer a unique opportunity to study the interaction of neutrinos with matter, a sensitive search for potential new physics effects, and a probe of solar structure and solar system formation. This paper describes the broad physics program addressed by solar neutrino studies, presents the current suite of experiments programs, and describes several potential future detectors that could address the open questions in this field. This paper is a summary of a talk presented at the Neutrino 2014 conference in Boston.

Polyelectrolyte Multilayer Film Coated Silver Nanorods: An Effective Carrier System for Externally Activated Drug Delivery

NASA Astrophysics Data System (ADS)

Paramasivam, Gokul; Sharma, Varsha; Sundaramurthy, Anandhakumar

2017-08-01

Nanoparticle anisotropy offers unique functions and features in comparison with spherical nanoparticles (NPs) and makes anisotropic nanoparticles (ANPs) promising candidates in applications like drug delivery, imaging, biosensing and theranostics. Presence of surface active groups (e.g. amine, and carboxylate groups) on their surface provides binding sites for ligands or other biomolecules, and hence, this could be targeted for specific part or cells in our body. In the quest of such surface modification, functionalization of ANPs along Layer-by-Layer (LbL) coating of oppositely charged polyelectrolytes (PE) reduces cellular toxicity and promotes easy encapsulation of drugs. In this work, we report the silver nanorods (AgNRs) synthesis by adsorbate directed synthetic approach using cetyltrimethyl ammonium bromide (CTAB). The formed ANPs is investigated by scanning electron microscopy (SEM) and UV-Visible (UV-Vis) spectroscopy revealing the shaping of AgNRs of 3-16 nm aspect ratio with some presence of triangles. These NRs were further coated with bio polymers of chitosan (CH) and dextran sulphate (DS) through LbL approach and used for encapsulation of water soluble anti-bacterial drugs like ciprofloxacin hydrochloride (CFH). The encapsulation of drugs and profiles of drug release were investigated and compared to that of spherical silver nanoparticles (AgNPs). The added advantages of the proposed drug delivery system (DDS) can be externally activated to release the loaded drug and used as contrast agents for biological imaging under exposure to NIR light. Such system shows unique and attractive characteristics required for drug delivery and bioimaging thus offering the scope for further development as theranostic material.

Onboard Systems Record Unique Videos of Space Missions

NASA Technical Reports Server (NTRS)

2010-01-01

Ecliptic Enterprises Corporation, headquartered in Pasadena, California, provided onboard video systems for rocket and space shuttle launches before it was tasked by Ames Research Center to craft the Data Handling Unit that would control sensor instruments onboard the Lunar Crater Observation and Sensing Satellite (LCROSS) spacecraft. The technological capabilities the company acquired on this project, as well as those gained developing a high-speed video system for monitoring the parachute deployments for the Orion Pad Abort Test Program at Dryden Flight Research Center, have enabled the company to offer high-speed and high-definition video for geosynchronous satellites and commercial space missions, providing remarkable footage that both informs engineers and inspires the imagination of the general public.

Measurements of Discrete Symmetries in the Neutral Kaon System with the CPLEAR (PS195) Experiment

NASA Astrophysics Data System (ADS)

Ruf, Thomas

2015-07-01

The antiproton storage ring LEAR offered unique opportunities to study the symmetries which exist between matter and antimatter. At variance with other approaches at this facility, CPLEAR was an experiment devoted to the study of T, \\{CPT} and \\{CP} symmetries in the neutral kaon system. It measured with high precision the time evolution of initially strangeness-tagged K0 and overline K ^0 states to determine the size of violations with respect to these symmetries in the context of a systematic study. In parallel, limits concerning quantum-mechanical predictions (EPR paradox, coherence of the wave function) or the equivalence principle of general relativity have been obtained. This article will first discuss briefly the unique low energy antiproton storage ring LEAR followed by a description of the CPLEAR experiment, including the basic formalism necessary to understand the time evolution of a neutral kaon state and the main results related to measurements of discrete symmetries in the neutral kaon system. An excellent and exhaustive review of the CPLEAR experiment and all its measurements is given in Ref. 1.

Fundamentals of pulmonary drug delivery.

PubMed

Groneberg, D A; Witt, C; Wagner, U; Chung, K F; Fischer, A

2003-04-01

Aerosol administration of peptide-based drugs plays an important role in the treatment of pulmonary and systemic diseases and the unique cellular properties of airway epithelium offers a great potential to deliver new compounds. As the relative contributions from the large airways to the alveolar space are important to the local and systemic availability, the sites and mechanism of uptake and transport of different target compounds have to be characterized. Among the different respiratory cells, the ciliated epithelial cells of the larger and smaller airways and the type I and type II pneumocytes are the key players in pulmonary drug transport. With their diverse cellular characteristics, each of these cell types displays a unique uptake possibility. Next to the knowledge of these cellular aspects, the nature of aerosolized drugs, characteristics of delivery systems and the depositional and pulmonary clearance mechanisms display major targets to optimize pulmonary drug delivery. Based on the growing knowledge on pulmonary cell biology and pathophysiology due to modern methods of molecular biology, the future characterization of pulmonary drug transport pathways can lead to new strategies in aerosol drug therapy.

An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives.

PubMed

Randolph, Lauren N; Bao, Xiaoping; Zhou, Chikai; Lian, Xiaojun

2017-05-08

Human pluripotent stem cells (hPSCs) offer tremendous promise in tissue engineering and cell-based therapies due to their unique combination of two properties: pluripotency and unlimited proliferative capacity. However, directed differentiation of hPSCs to clinically relevant cell lineages is needed to achieve the goal of hPSC-based therapies. This requires a deep understanding of how cell signaling pathways converge on the nucleus to control differentiation and the ability to dissect gene function in a temporal manner. Here, we report the use of the PiggyBac transposon and a Tet-On 3G drug-inducible gene expression system to achieve versatile inducible gene expression in hPSC lines. Our new system, XLone, offers improvement over previous Tet-On systems with significantly reduced background expression and increased sensitivity to doxycycline. Transgene expression in hPSCs is tightly regulated in response to doxycycline treatment. In addition, the PiggyBac elements in our XLone construct provide a rapid and efficient strategy for generating stable transgenic hPSCs. Our inducible gene expression PiggyBac transposon system should facilitate the study of gene function and directed differentiation in human stem cells.

Impact of Hospital Information Systems on Emergency Patient Processing

PubMed Central

Rusnak, James E.

1981-01-01

The Emergency Department offers the Hospital Information System's designer some unique problems to solve in the operational areas of patient registration, order entry, charge recording, and treatment processing. In a number of instances, Hospital Information Systems implementers have encountered serious difficulties in trying to design system components to support the requirements of the Emergency Services Department's operations. Washington Hospital has developed a very effective system for Emergency Services. The system's features are designed to meet the special requirements of the department and to maximize the use of the data captured by the Hospital Information System. The system supports accurate and timely charging for services. The treatment of the patient has been dramatically improved through the use of a computerized order processing and control. The installed systems resulted in a higher quality of care and cost effective operations.

NASA'S Space Launch System: Opening Opportunities for Mission Design

NASA Technical Reports Server (NTRS)

Robinson, Kimberly F.; Hefner, Keith; Hitt, David

2015-01-01

Designed to meet the stringent requirements of human exploration missions into deep space and to Mars, NASA's Space Launch System (SLS) vehicle represents a unique new launch capability opening new opportunities for mission design. While SLS's super-heavy launch vehicle predecessor, the Saturn V, was used for only two types of missions - launching Apollo spacecraft to the moon and lofting the Skylab space station into Earth orbit - NASA is working to identify new ways to use SLS to enable new missions or mission profiles. In its initial Block 1 configuration, capable of launching 70 metric tons (t) to low Earth orbit (LEO), SLS is capable of not only propelling the Orion crew vehicle into cislunar space, but also delivering small satellites to deep space destinations. With a 5-meter (m) fairing consistent with contemporary Evolved Expendable Launch Vehicles (EELVs), the Block 1 configuration can also deliver science payloads to high-characteristic-energy (C3) trajectories to the outer solar system. With the addition of an upper stage, the Block 1B configuration of SLS will be able to deliver 105 t to LEO and enable more ambitious human missions into the proving ground of space. This configuration offers opportunities for launching co-manifested payloads with the Orion crew vehicle, and a new class of secondary payloads, larger than today's cubesats. The evolved configurations of SLS, including both Block 1B and the 130 t Block 2, also offer the capability to carry 8.4- or 10-m payload fairings, larger than any contemporary launch vehicle. With unmatched mass-lift capability, payload volume, and C3, SLS not only enables spacecraft or mission designs currently impossible with contemporary EELVs, it also offers enhancing benefits, such as reduced risk and operational costs associated with shorter transit time to destination and reduced risk and complexity associated with launching large systems either monolithically or in fewer components. As this paper will demonstrate, SLS is making strong progress toward first launch, and represents a unique new capability for spaceflight, and an opportunity to reinvent space by developing out-of-the-box missions and mission designs unlike any flown before.

NASA's Space Launch System: An Evolving Capability for Exploration

NASA Technical Reports Server (NTRS)

Crumbly, Christopher M.; Creech, Stephen D.; Robinson,Kimberly F.

2016-01-01

Designed to meet the stringent requirements of human exploration missions into deep space and to Mars, NASA's Space Launch System (SLS) vehicle represents a unique new launch capability opening new opportunities for mission design. While SLS's super-heavy launch vehicle predecessor, the Saturn V, was used for only two types of missions - launching Apollo spacecraft to the moon and lofting the Skylab space station into Earth orbit - NASA is working to identify new ways to use SLS to enable new missions or mission profiles. In its initial Block 1 configuration, capable of launching 70 metric tons (t) to low Earth orbit (LEO), SLS is capable of not only propelling the Orion crew vehicle into cislunar space, but also delivering small satellites to deep space destinations. With a 5-meter (m) fairing consistent with contemporary Evolved Expendable Launch Vehicles (EELVs), the Block 1 configuration can also deliver science payloads to high-characteristic-energy (C3) trajectories to the outer solar system. With the addition of an upper stage, the Block 1B configuration of SLS will be able to deliver 105 t to LEO and enable more ambitious human missions into the proving ground of space. This configuration offers opportunities for launching co-manifested payloads with the Orion crew vehicle, and a new class of secondary payloads, larger than today's cubesats. The evolved configurations of SLS, including both Block 1B and the 130 t Block 2, also offer the capability to carry 8.4- or 10-m payload fairings, larger than any contemporary launch vehicle. With unmatched mass-lift capability, payload volume, and C3, SLS not only enables spacecraft or mission designs currently impossible with contemporary EELVs, it also offers enhancing benefits, such as reduced risk and operational costs associated with shorter transit time to destination and reduced risk and complexity associated with launching large systems either monolithically or in fewer components. As this paper will demonstrate, SLS represents a unique new capability for spaceflight, and an opportunity to reinvent space by developing out-of-the-box missions and mission designs unlike any flown before.

Planarian brain regeneration as a model system for developmental neurotoxicology

PubMed Central

Hagstrom, Danielle; Cochet‐Escartin, Olivier

2016-01-01

Abstract Freshwater planarians, famous for their regenerative prowess, have long been recognized as a valuable in vivo animal model to study the effects of chemical exposure. In this review, we summarize the current techniques and tools used in the literature to assess toxicity in the planarian system. We focus on the planarian's particular amenability for neurotoxicology and neuroregeneration studies, owing to the planarian's unique ability to regenerate a centralized nervous system. Zooming in from the organismal to the molecular level, we show that planarians offer a repertoire of morphological and behavioral readouts while also being amenable to mechanistic studies of compound toxicity. Finally, we discuss the open challenges and opportunities for planarian brain regeneration to become an important model system for modern toxicology. PMID:27499880

Contrast-enhanced photoacoustic tomography of human joints

NASA Astrophysics Data System (ADS)

Tian, Chao; Keswani, Rahul K.; Gandikota, Girish; Rosania, Gus R.; Wang, Xueding

2016-03-01

Photoacoustic tomography (PAT) provides a unique tool to diagnose inflammatory arthritis. However, the specificity and sensitivity of PAT based on endogenous contrasts is limited. The development of contrast enhanced PAT imaging modalities in combination with small molecule contrast agents could lead to improvements in diagnosis and treatment of joint disease. Accordingly, we adapted and tested a PAT clinical imaging system for imaging the human joints, in combination with a novel PAT contrast agent derived from an FDA-approved small molecule drug. Imaging results based on a photoacoustic and ultrasound (PA/US) dual-modality system revealed that this contrast-enhanced PAT imaging system may offer additional information beyond single-modality PA or US imaging system, for the imaging, diagnosis and assessment of inflammatory arthritis.

Novel materials for electrochemical power sources—introduction of PUREBLACK ® Carbons

NASA Astrophysics Data System (ADS)

Barsukov, Igor V.; Gallego, Maritza A.; Doninger, Joseph E.

Graphitization heat treatment of a precursor carbon black was seen to effectively produce a wide variety of forms of partially graphitized nano-sized carbonaceous materials with a set of unique properties, some of which are reported in this paper in comparison with those properties of the precursor carbon material. These novel materials were given the name of PUREBLACK ® Carbons. Among some of the unique properties are: higher conductivity than that of acetylene type carbon blacks due to PUREBLACK ® Carbon's particles having more graphitic structure; very low to zero volatile content (external oxygen, sulfur, etc., groups, which are often believed to be the cause of initiation of self-discharge reactions in batteries); very low equilibrium moisture pickup (20 ppm level), which makes it particularly attractive in lithium metal or lithium-ion based electrochemical systems; high purity. Electrochemical testing of the newly proposed PUREBLACK ® Carbons in several battery systems offers significant promise that it presents a viable solution to the needs of industry.

C to VHDL compiler

NASA Astrophysics Data System (ADS)

Berdychowski, Piotr P.; Zabolotny, Wojciech M.

2010-09-01

The main goal of C to VHDL compiler project is to make FPGA platform more accessible for scientists and software developers. FPGA platform offers unique ability to configure the hardware to implement virtually any dedicated architecture, and modern devices provide sufficient number of hardware resources to implement parallel execution platforms with complex processing units. All this makes the FPGA platform very attractive for those looking for efficient heterogeneous, computing environment. Current industry standard in development of digital systems on FPGA platform is based on HDLs. Although very effective and expressive in hands of hardware development specialists, these languages require specific knowledge and experience, unreachable for most scientists and software programmers. C to VHDL compiler project attempts to remedy that by creating an application, that derives initial VHDL description of a digital system (for further compilation and synthesis), from purely algorithmic description in C programming language. This idea itself is not new, and the C to VHDL compiler combines the best approaches from existing solutions developed over many previous years, with the introduction of some new unique improvements.

Generating unique IDs from patient identification data using security models.

PubMed

Mohammed, Emad A; Slack, Jonathan C; Naugler, Christopher T

2016-01-01

The use of electronic health records (EHRs) has continued to increase within healthcare systems in the developed and developing nations. EHRs allow for increased patient safety, grant patients easier access to their medical records, and offer a wealth of data to researchers. However, various bioethical, financial, logistical, and information security considerations must be addressed while transitioning to an EHR system. The need to encrypt private patient information for data sharing is one of the foremost challenges faced by health information technology. We describe the usage of the message digest-5 (MD5) and secure hashing algorithm (SHA) as methods for encrypting electronic medical data. In particular, we present an application of the MD5 and SHA-1 algorithms in encrypting a composite message from private patient information. The results show that the composite message can be used to create a unique one-way encrypted ID per patient record that can be used for data sharing. The described software tool can be used to share patient EMRs between practitioners without revealing patients identifiable data.

Can banks offer digital keys for health care?

PubMed

Casillas, John

2013-01-01

In the quest to implement electronic health care records, health care stakeholders have uncovered an elephant in the room - how to implement patient identity and integrity solutions. Without this, linking the unique records of an individual is impossible. An inaccurate record can be dangerous for prescribing treatment. Yet many consider a unique patient identifier as an unacceptable privacy risk. Medical banking, or the convergence of banking and heath IT systems, is spawning new ideas that could impact on this difficult area. This article suggests that new forms of efficiency in payment processing may yield a common, cross-industry technology platform for managing digital identity by banks. Redefining a bank based on core competencies, the article looks at three areas: (1) the "identity theft arms race"; (2) innovations in payment processing; and (3) consumer engagement, and suggests that, as banking and health care systems converge, digital identity may become the new money. This realization may find banks fully engaged in helping health care to overcome the challenge of patient identity and integrity.

Redox Flow Batteries, Hydrogen and Distributed Storage.

PubMed

Dennison, C R; Vrubel, Heron; Amstutz, Véronique; Peljo, Pekka; Toghill, Kathryn E; Girault, Hubert H

2015-01-01

Social, economic, and political pressures are causing a shift in the global energy mix, with a preference toward renewable energy sources. In order to realize widespread implementation of these resources, large-scale storage of renewable energy is needed. Among the proposed energy storage technologies, redox flow batteries offer many unique advantages. The primary limitation of these systems, however, is their limited energy density which necessitates very large installations. In order to enhance the energy storage capacity of these systems, we have developed a unique dual-circuit architecture which enables two levels of energy storage; first in the conventional electrolyte, and then through the formation of hydrogen. Moreover, we have begun a pilot-scale demonstration project to investigate the scalability and technical readiness of this approach. This combination of conventional energy storage and hydrogen production is well aligned with the current trajectory of modern energy and mobility infrastructure. The combination of these two means of energy storage enables the possibility of an energy economy dominated by renewable resources.

Epilepsy: habilitation and rehabilitation.

PubMed

Marks, Warren A; Hernandez, Angel; Gabriel, Marsha

2003-06-01

Rehabilitation represents not only a distinct field of medicine, but also a philosophical and practical treatment approach that can be applied to a variety of chronic disorders. Neurology encompasses many chronic disorders, making it ideal for the application of rehabilitation principles in daily practice. Epilepsy offers a unique opportunity to incorporate rehabilitation principles into the management of a complex medical disorder. Epilepsy is an evolving disease process that changes with the maturation of the central nervous system. The rehabilitative model provides the framework for a dynamic treatment plan to meet the changing needs of the child with epilepsy through the social and developmental changes of childhood, adolescence, and adulthood. The development of epilepsy may complicate the recovery from many acute and chronic conditions that affect the central nervous system. The rehabilitation process must address these many aspects of the disease process and its sequelae. This makes neurologists uniquely qualified to manage the rehabilitation team. The impact of the therapeutic milieu on the recovery process may be as important as any specific medical or surgical intervention.

Advantages and challenges offered by biofunctional core-shell fiber systems for tissue engineering and drug delivery.

PubMed

Sperling, Laura E; Reis, Karina P; Pranke, Patricia; Wendorff, Joachim H

2016-08-01

Whereas highly porous scaffolds composed of electrospun nanofibers can mimick major features of the extracellular matrix in tissue engineering, they lack the ability to incorporate and release biocompounds (drugs, growth factors) safely in a controlled way. Here, electrospun core-shell fibers (core made from water and aqueous solutions of hydrophilic polymers and the shell from materials with well-defined release mechanisms) offer unique advantages in comparison with those that have helped make porous nanofibrillar scaffolds highly successful in tissue engineering. This review considers the preparation and biofunctionalization of such core-shell fibers as well as applications in various areas, including neural, vascular, cardiac, cartilage and bone tissue engineering, and touches on the topic of clinical trials. Copyright © 2016 Elsevier Ltd. All rights reserved.

Speaking Volumes About 3-D

NASA Technical Reports Server (NTRS)

2002-01-01

In 1999, Genex submitted a proposal to Stennis Space Center for a volumetric 3-D display technique that would provide multiple users with a 360-degree perspective to simultaneously view and analyze 3-D data. The futuristic capabilities of the VolumeViewer(R) have offered tremendous benefits to commercial users in the fields of medicine and surgery, air traffic control, pilot training and education, computer-aided design/computer-aided manufacturing, and military/battlefield management. The technology has also helped NASA to better analyze and assess the various data collected by its satellite and spacecraft sensors. Genex capitalized on its success with Stennis by introducing two separate products to the commercial market that incorporate key elements of the 3-D display technology designed under an SBIR contract. The company Rainbow 3D(R) imaging camera is a novel, three-dimensional surface profile measurement system that can obtain a full-frame 3-D image in less than 1 second. The third product is the 360-degree OmniEye(R) video system. Ideal for intrusion detection, surveillance, and situation management, this unique camera system offers a continuous, panoramic view of a scene in real time.

NASA's Space Launch System: Deep-Space Delivery for SmallSats

NASA Technical Reports Server (NTRS)

Robinson, Kimberly F.; Norris, George

2017-01-01

Designed for human exploration missions into deep space, NASA's Space Launch System (SLS) represents a new spaceflight infrastructure asset, enabling a wide variety of unique utilization opportunities. While primarily focused on launching the large systems needed for crewed spaceflight beyond Earth orbit, SLS also offers a game-changing capability for the deployment of small satellites to deep-space destinations, beginning with its first flight. Currently, SLS is making rapid progress toward readiness for its first launch in two years, using the initial configuration of the vehicle, which is capable of delivering more than 70 metric tons (t) to Low Earth Orbit (LEO). Planning is underway for smallsat accomodations on future configurations of the vehicle, which will present additional opportunities. This paper will include an overview of the SLS vehicle and its capabilities, including the current status of progress toward first launch. It will also explain the current and future opportunities the vehicle offers for small satellites, including an overview of the CubeSat manifest for Exploration Mission-1 in 2018 and a discussion of future capabilities.

Outdoor Recreation and Applied Ecology. Revised.

ERIC Educational Resources Information Center

Hendren, Travis E.; And Others

This curriculum guide offers guidelines for structuring a course which exposes the students to various environmental careers. The guide is divided into three sections. The first section offers information about such a course: course description, purpose, credits, special or unique aspects, physical facilities, equipment, major materials, teacher…

“Modular Biospheres” New testbed platforms for public environmental education and research

NASA Astrophysics Data System (ADS)

Nelson, M.; Dempster, W. F.; Allen, J. P.

This paper will review the potential of a relatively new type of testbed platform for environmental education and research because of the unique advantages resulting from their material closure and separation from the outside environment. These facilities which we term "modular biospheres", have emerged from research centered on space life support research but offer a wider range of application. Examples of this type of facility include the Bios-3 facility in Russia, the Japanese CEEF (Closed Ecological Experiment Facility), the NASA Kennedy Space Center Breadboard facility, the Biosphere 2 Test Module and the Laboratory Biosphere. Modular biosphere facilities offer unique research and public real-time science education opportunities. Ecosystem behavior can be studied since initial state conditions can be precisely specified and tracked over different ranges of time. With material closure (apart from very small air exchange rate which can be determined), biogeochemical cycles between soil and soil microorganisms, water, plants, and atmosphere can be studied in detail. Such studies offer a major advance from studies conducted with phytotrons which because of their small size, limit the number of organisms to a very small number, and which crucially do not have a high degree of atmospheric, water and overall material closure. Modular biospheres take advantage of the unique properties of closure, as representing a distinct system "metabolism" and therefore are essentially a "mini-world". Though relatively large in comparison with most phytotrons and ecological microcosms, which are now standard research and educational tools, modular biospheres are small enough that they can be economically reconfigured to reflect a changing research agenda. Some design elements include lighting via electric lights and/or sunlight, hydroponic or soil substrate for plants, opaque or glazed structures, and variable volume chambers or other methods to handle atmospheric pressure differences between the facility and the outside environment.

Policy Perspective: Ensuring Comprehensive Care and Support for Gender Nonconforming Children and Adolescents

PubMed Central

Dowshen, Nadia; Meadows, Rachel; Byrnes, Maureen; Hawkins, Linda; Eder, Jennifer; Noonan, Kathleen

2016-01-01

Abstract Despite recent notable advances in societal equality for lesbian, gay, bisexual, and transgender (LGBT) individuals, youth who identify as trans* or gender nonconforming, in particular, continue to experience significant challenges accessing the services they need to grow into healthy adults. This policy perspective first offers background information describing this population, their unique healthcare needs, and obstacles when seeking care, including case study examples. The authors then provide recommendations for medical education, health systems, and insurance payers, as well as recommendations for school systems and broader public policy changes to improve the health and well-being of gender nonconforming youth. PMID:28861528

Vector Meson Production at Hera

NASA Astrophysics Data System (ADS)

Szuba, Dorota

The diffractive production of vector mesons ep→eVMY, with VM=ρ0, ω, ϕ, J/ψ, ψ‧ or ϒ and with Y being either the scattered proton or a low mass hadronic system, has been extensively investigated at HERA. HERA offers a unique opportunity to study the dependences of diffractive processes on different scales: the mass of the vector meson, mVM, the centre-of-mass energy of the γp system, W, the photon virtuality, Q2 and the four-momentum transfer squared at the proton vertex, |t|. Strong interactions can be investigated in the transition from the hard to the soft regime, where the confinement of quarks and gluons occurs.

Medical Education Capacity-Building Partnerships for Health Care Systems Development.

PubMed

Rabin, Tracy L; Mayanja-Kizza, Harriet; Rastegar, Asghar

2016-07-01

Health care workforce development is a key pillar of global health systems strengthening that requires investment in health care worker training institutions. This can be achieved by developing partnerships between training institutions in resource-limited and resource-rich areas and leveraging the unique expertise and opportunities both have to offer. To realize their full potential, however, these relationships must be equitable. In this article, we use a previously described global health ethics framework and our ten-year experience with the Makerere University-Yale University (MUYU) Collaboration to provide an example of an equity-focused global health education partnership. © 2016 American Medical Association. All Rights Reserved. ISSN 2376-6980.

Techno-economic sensitivity study of heliostat field parameters for micro-gas turbine CSP

NASA Astrophysics Data System (ADS)

Landman, Willem A.; Gauché, Paul; Dinter, Frank; Myburgh, J. T.

2017-06-01

Concentrating solar power systems based on micro-gas turbines potentially offer numerous benefits should they become commercially viable. Heliostat fields for such systems have unique requirements in that the number of heliostats and the focal ratios are typically much lower than conventional central receiver systems. This paper presents a techno-economic sensitivity study of heliostat field parameters for a micro-gas turbine central receiver system. A 100 kWe minitower system is considered for the base case and a one-at-a-time strategy is used to investigate parameter sensitivities. Increasing heliostat focal ratios are found to have significant optical performance benefits due to both a reduction in astigmatic aberrations and a reduction in the number of facet focal lengths required; confirming the hypothesis that smaller heliostats offer a techno-economic advantage. Fixed Horizontal Axis tracking mechanism is shown to outperform the conventional Azimuth Zenith tracking mechanism in high density heliostat fields. Although several improvements to heliostat field performance are discussed, the capex fraction of the heliostat field for such system is shown to be almost half that of a conventional central receiver system and optimum utilization of the higher capex components, namely; the receiver and turbine subsystems, are more rewarding than that of the heliostat field.

Advanced Fusion Reactors for Space Propulsion and Power Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chapman, John J.

In recent years the methodology proposed for conversion of light elements into energy via fusion has made steady progress. Scientific studies and engineering efforts in advanced fusion systems designs have introduced some new concepts with unique aspects including consideration of Aneutronic fuels. The plant parameters for harnessing aneutronic fusion appear more exigent than those required for the conventional fusion fuel cycle. However aneutronic fusion propulsion plants for Space deployment will ultimately offer the possibility of enhanced performance from nuclear gain as compared to existing ionic engines as well as providing a clean solution to Planetary Protection considerations and requirements. Protonmore » triggered 11Boron fuel (p- 11B) will produce abundant ion kinetic energy for In-Space vectored thrust. Thus energetic alpha particles' exhaust momentum can be used directly to produce high Isp thrust and also offer possibility of power conversion into electricity. p-11B is an advanced fusion plant fuel with well understood reaction kinematics but will require some new conceptual thinking as to the most effective implementation.« less

Advanced Fusion Reactors for Space Propulsion and Power Systems

NASA Technical Reports Server (NTRS)

Chapman, John J.

2011-01-01

In recent years the methodology proposed for conversion of light elements into energy via fusion has made steady progress. Scientific studies and engineering efforts in advanced fusion systems designs have introduced some new concepts with unique aspects including consideration of Aneutronic fuels. The plant parameters for harnessing aneutronic fusion appear more exigent than those required for the conventional fusion fuel cycle. However aneutronic fusion propulsion plants for Space deployment will ultimately offer the possibility of enhanced performance from nuclear gain as compared to existing ionic engines as well as providing a clean solution to Planetary Protection considerations and requirements. Proton triggered 11Boron fuel (p- 11B) will produce abundant ion kinetic energy for In-Space vectored thrust. Thus energetic alpha particles "exhaust" momentum can be used directly to produce high ISP thrust and also offer possibility of power conversion into electricity. p- 11B is an advanced fusion plant fuel with well understood reaction kinematics but will require some new conceptual thinking as to the most effective implementation.

NASA's Space Launch System: An Evolving Capability for Exploration

NASA Technical Reports Server (NTRS)

Creech, Stephen D.; Robinson, Kimberly F.

2016-01-01

Designed to meet the stringent requirements of human exploration missions into deep space and to Mars, NASA's Space Launch System (SLS) vehicle represents a unique new launch capability opening new opportunities for mission design. NASA is working to identify new ways to use SLS to enable new missions or mission profiles. In its initial Block 1 configuration, capable of launching 70 metric tons (t) to low Earth orbit (LEO), SLS is capable of not only propelling the Orion crew vehicle into cislunar space, but also delivering small satellites to deep space destinations. The evolved configurations of SLS, including both the 105 t Block 1B and the 130 t Block 2, offer opportunities for launching co-manifested payloads and a new class of secondary payloads with the Orion crew vehicle, and also offer the capability to carry 8.4- or 10-m payload fairings, larger than any contemporary launch vehicle, delivering unmatched mass-lift capability, payload volume, and C3.

Bionic Nanosystems

NASA Astrophysics Data System (ADS)

Sebastian Mannoor, Manu

Direct multidimensional integration of functional electronics and mechanical elements with viable biological systems could allow for the creation of bionic systems and devices possessing unique and advanced capabilities. For example, the ability to three dimensionally integrate functional electronic and mechanical components with biological cells and tissue could enable the creation of bionic systems that can have tremendous impact in regenerative medicine, prosthetics, and human-machine interfaces. However, as a consequence of the inherent dichotomy in material properties and limitations of conventional fabrication methods, the attainment of truly seamless integration of electronic and/or mechanical components with biological systems has been challenging. Nanomaterials engineering offers a general route for overcoming these dichotomies, primarily due to the existence of a dimensional compatibility between fundamental biological functional units and abiotic nanomaterial building blocks. One area of compelling interest for bionic systems is in the field of biomedical sensing, where the direct interfacing of nanosensors onto biological tissue or the human body could stimulate exciting opportunities such as on-body health quality monitoring and adaptive threat detection. Further, interfacing of antimicrobial peptide based bioselective probes onto the bionic nanosensors could offer abilities to detect pathogenic bacteria with bio-inspired selectivity. Most compellingly, when paired with additive manufacturing techniques such as 3D printing, these characteristics enable three dimensional integration and merging of a variety of functional materials including electronic, structural and biomaterials with viable biological cells, in the precise anatomic geometries of human organs, to form three dimensionally integrated, multi-functional bionic hybrids and cyborg devices with unique capabilities. In this thesis, we illustrate these approaches using three representative bionic systems: 1) Bionic Nanosensors: featuring bio-integrated graphene nanosensors for ubiquitous sensing, 2) Bionic Organs: featuring 3D printed bionic ears with three dimensionally integrated electronics and 3) Bionic Leaves: describing ongoing work in the direction of the creation of a bionic leaf enabled by the integration of plant derived photosynthetic functional units with electronic materials and components into a leaf-shaped hierarchical structure for harvesting photosynthetic bioelectricity.

Electronic and School-Based Victimization: Unique Contexts for Adjustment Difficulties during Adolescence

ERIC Educational Resources Information Center

Fredstrom, Bridget K.; Adams, Ryan E.; Gilman, Rich

2011-01-01

Previous research suggests that school-based and electronic victimization have similar negative consequences, yet it is unclear whether these two contexts offer overlapping or unique associations with adolescents' adjustment. 802 ninth-graders (43% male, mean age = 15.84 years), majority being Caucasian (82%), completed measures assessing the…

Practical relevance of pattern uniqueness in forensic science.

PubMed

Jayaprakash, Paul T

2013-09-10

Uniqueness being unprovable, it has recently been argued that individualization in forensic science is irrelevant and, probability, as applied for DNA profiles, should be applied for all identifications. Critiques against uniqueness have omitted physical matching, a realistic and tangible individualization that supports uniqueness. Describing case examples illustrating pattern matches including physical matching, it is indicated that individualizations are practically relevant for forensic science as they establish facts on a definitive basis providing firm leads benefitting criminal investigation. As a tenet of forensic identification, uniqueness forms a fundamental paradigm relevant for individualization. Evidence on the indeterministic and stochastic causal pathways of characteristics in patterns available in the related fields of science sufficiently supports the proposition of uniqueness. Characteristics involved in physical matching and matching achieved in patterned evidence existing in the state of nature are not events amenable for counting; instead these are ensemble of visible units occupying the entire pattern area stretching the probability of re-occurrence of a verisimilitude pattern into infinity offering epistemic support to uniqueness. Observational methods are as respectable as instrumental or statistical methods since they are capable of generating results that are tangible and obviously valid as in physical matching. Applying the probabilistic interpretation used for DNA profiles to the other patterns would be unbefitting since these two are disparate, the causal pathways of the events, the loci, in the manipulated DNA profiles being determinable. While uniqueness enables individualizations, it does not vouch for eliminating errors. Instead of dismissing uniqueness and individualization, accepting errors as human or system failures and seeking remedial measures would benefit forensic science practice and criminal investigation. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Predictors of acceptance of offered care management intervention services in a quality improvement trial for dementia.

PubMed

Kaisey, Marwa; Mittman, Brian; Pearson, Marjorie; Connor, Karen I; Chodosh, Joshua; Vassar, Stefanie D; Nguyen, France T; Vickrey, Barbara G

2012-10-01

Care management approaches have been proven to improve outcomes for patients with dementia and their family caregivers (dyads). However, acceptance of services in these programs is incomplete, impacting effectiveness. Acceptance may be related to dyad as well as healthcare system characteristics, but knowledge about factors associated with program acceptance is lacking. This study investigates patient, caregiver, and healthcare system characteristics associated with acceptance of offered care management services. This study analyzed data from the intervention arm of a cluster randomized controlled trial of a comprehensive dementia care management intervention. There were 408 patient-caregiver dyads enrolled in the study, of which 238 dyads were randomized to the intervention. Caregiver, patient, and health system factors associated with participation in offered care management services were assessed through bivariate and multivariate regression analyses. Out of the 238 dyads, 9 were ineligible for this analysis, leaving data of 229 dyads in this sample. Of these, 185 dyads accepted offered care management services, and 44 dyads did not. Multivariate analyses showed that higher likelihood of acceptance of care management services was uniquely associated with cohabitation of caregiver and patient (p < 0.001), lesser severity of dementia (p = 0.03), and higher patient comorbidity (p = 0.03); it also varied across healthcare organization sites. Understanding factors that influence care management participation could result in increased adoption of successful programs to improve quality of care. Using these factors to revise both program design as well as program promotion may also benefit external validity of future quality improvement research trials. Copyright © 2011 John Wiley & Sons, Ltd.

Formal Requirements-Based Programming for Complex Systems

NASA Technical Reports Server (NTRS)

Rash, James L.; Hinchey, Michael G.; Rouff, Christopher A.; Gracanin, Denis

2005-01-01

Computer science as a field has not yet produced a general method to mechanically transform complex computer system requirements into a provably equivalent implementation. Such a method would be one major step towards dealing with complexity in computing, yet it remains the elusive holy grail of system development. Currently available tools and methods that start with a formal model of a system and mechanically produce a provably equivalent implementation are valuable but not sufficient. The gap that such tools and methods leave unfilled is that the formal models cannot be proven to be equivalent to the system requirements as originated by the customer For the classes of complex systems whose behavior can be described as a finite (but significant) set of scenarios, we offer a method for mechanically transforming requirements (expressed in restricted natural language, or appropriate graphical notations) into a provably equivalent formal model that can be used as the basis for code generation and other transformations. While other techniques are available, this method is unique in offering full mathematical tractability while using notations and techniques that are well known and well trusted. We illustrate the application of the method to an example procedure from the Hubble Robotic Servicing Mission currently under study and preliminary formulation at NASA Goddard Space Flight Center.

Sandboxes for Model-Based Inquiry

NASA Astrophysics Data System (ADS)

Brady, Corey; Holbert, Nathan; Soylu, Firat; Novak, Michael; Wilensky, Uri

2015-04-01

In this article, we introduce a class of constructionist learning environments that we call Emergent Systems Sandboxes ( ESSs), which have served as a centerpiece of our recent work in developing curriculum to support scalable model-based learning in classroom settings. ESSs are a carefully specified form of virtual construction environment that support students in creating, exploring, and sharing computational models of dynamic systems that exhibit emergent phenomena. They provide learners with "entity"-level construction primitives that reflect an underlying scientific model. These primitives can be directly "painted" into a sandbox space, where they can then be combined, arranged, and manipulated to construct complex systems and explore the emergent properties of those systems. We argue that ESSs offer a means of addressing some of the key barriers to adopting rich, constructionist model-based inquiry approaches in science classrooms at scale. Situating the ESS in a large-scale science modeling curriculum we are implementing across the USA, we describe how the unique "entity-level" primitive design of an ESS facilitates knowledge system refinement at both an individual and social level, we describe how it supports flexible modeling practices by providing both continuous and discrete modes of executability, and we illustrate how it offers students a variety of opportunities for validating their qualitative understandings of emergent systems as they develop.

Videofile for Law Enforcement

NASA Technical Reports Server (NTRS)

1977-01-01

Components of a videotape storage and retrieval system originally developed for NASA have been adapted as a tool for law enforcement agencies. Ampex Corp., Redwood City, Cal., built a unique system for NASA-Marshall. The first application of professional broadcast technology to computerized record-keeping, it incorporates new equipment for transporting tapes within the system. After completing the NASA system, Ampex continued development, primarily to improve image resolution. The resulting advanced system, known as the Ampex Videofile, offers advantages over microfilm for filing, storing, retrieving, and distributing large volumes of information. The system's computer stores information in digital code rather than in pictorial form. While microfilm allows visual storage of whole documents, it requires a step before usage--developing the film. With Videofile, the actual document is recorded, complete with photos and graphic material, and a picture of the document is available instantly.

Compounding Opportunities in Urology.

PubMed

Biundo, Bruce

2017-01-01

There are a lot of options that pharmacists, including compounding pharmacists, can offer urologists to assist their patients. Compounding pharmacists are in a great position to offer unique, effective preparations for many of the conditions urologists treat on a daily basis. It would be well worth the time to learn a little about the conditions these specialists treat and become familiar with what you can offer. Copyright© by International Journal of Pharmaceutical Compounding, Inc.

An Examination of the Determinants of Top Management Support of Information Technology Projects

ERIC Educational Resources Information Center

Mahoney, Michael L.

2011-01-01

Despite compelling evidence that top management support promotes information technology project success, existing research fails to offer insight into the antecedents of top management support of such projects. This gap in the literature is significant since the exploitation of information technology offers organizations unique opportunities for…

The Japanese Mind: Understanding Contemporary Japanese Culture.

ERIC Educational Resources Information Center

Davies, Roger J., Ed.; Ikeno, Osamu, Ed.

This collection of essays offers an overview of contemporary Japanese culture, and can serve as a resource for classes studying Japan. The 28 essays offer an informative, accessible look at the values, attitudes, behavior patterns, and communication styles of modern Japan from the unique perspective of the Japanese people. Filled with examples…

76 FR 54998 - Request for Information on Consumer Financial Products and Services Offered to Servicemembers

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... public disclosure. Sensitive personal information such as account numbers or Social Security numbers... in person and online? 4. What programs, policies, accommodations, or benefits do financial service... protections and fraud protections. 5. What unique assistance, if any, is currently offered by financial...

Some questions of space bioengineering

NASA Technical Reports Server (NTRS)

Nyiri, L. K.

1977-01-01

Zero-gravity offers selective effect on growth and metabolic activity unicellular organisms as well as unique opportunities in purification of organic compounds. These make it possible to consider the biosynthesis and recovery of certain metabolites economically feasible in space. Design, construction and operation of systems for the above mentioned purposes requires interdisciplinary actions within the scope of a new discipline: space bioengineering. The problems and perspectives of this discipline particularly in the application of bioreactor-recovery systems in space to manufacture metabolites of high economic and scientific value. Special attention is paid to pivotal factors such as various mass transport phenomena, contamination control, automatic control of optimum environment and synchronization of the operation of the biological (biosynthesis) and the physiochemical (recovery-purification) systems.

Lafora disease offers a unique window into neuronal glycogen metabolism.

PubMed

Gentry, Matthew S; Guinovart, Joan J; Minassian, Berge A; Roach, Peter J; Serratosa, Jose M

2018-05-11

Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals with LD develop cytoplasmic, aberrant glycogen inclusions in nearly all tissues that more closely resemble plant starch than human glycogen. This Minireview discusses the unique window into glycogen metabolism that LD research offers. It also highlights recent discoveries, including that glycogen contains covalently bound phosphate and that neurons synthesize glycogen and express both glycogen synthase and glycogen phosphorylase. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

FEL for the polymer processing industries

NASA Astrophysics Data System (ADS)

Kelley, Michael J.

1997-05-01

Polymers are everywhere in modern life because of their unique combination of end-use functionalities, ease of processing, recycling potential and modest cost. The physical and economic scope of the infrastructure committed to present polymers makes the introduction of entirely new chemistry unlikely. Rather, the breadth of commercial offerings more likely to shrink in the face of the widening mandate for recycling, especially of packaging. Improved performance and new functionality must therefore come by routes such as surface modification. However they must come with little environmental impact and at painfully low cost. Processing with strongly absorbed light offers unique advantages. The journal and patent literatures disclose a number of examples of benefits that can be achieved, principally by use of excimer lasers or special UV lamps. Examples of commercialization are few, however, because of the unit cost and maximum scale of existing light sources. A FEL, however, offers unique advantages: tunability to the optimum wavelength, potential for scale up to high average power, and a path to attractively low unit cost of light. A business analysis of prospective applications defines the technical and economic requirements a FEL for polymer surface processing must meet. These are compared to FEL technology as it now stands and as it is envisioned.

Size-dependent chemical transformation, structural phase-change, and optical properties of nanowires

PubMed Central

Piccione, Brian; Agarwal, Rahul; Jung, Yeonwoong; Agarwal, Ritesh

2013-01-01

Nanowires offer a unique approach for the bottom up assembly of electronic and photonic devices with the potential of integrating photonics with existing technologies. The anisotropic geometry and mesoscopic length scales of nanowires also make them very interesting systems to study a variety of size-dependent phenomenon where finite size effects become important. We will discuss the intriguing size-dependent properties of nanowire systems with diameters in the 5 – 300 nm range, where finite size and interfacial phenomena become more important than quantum mechanical effects. The ability to synthesize and manipulate nanostructures by chemical methods allows tremendous versatility in creating new systems with well controlled geometries, dimensions and functionality, which can then be used for understanding novel processes in finite-sized systems and devices. PMID:23997656

Antibiotic-containing polymers for localized, sustained drug delivery

PubMed Central

Stebbins, Nicholas D.; Ouimet, Michelle A.; Uhrich, Kathryn E.

2014-01-01

Many currently used antibiotics suffer from issues such as systemic toxicity, short half-life, and increased susceptibility to bacterial resistance. Although most antibiotic classes are administered systemically through oral or intravenous routes, a more efficient delivery system is needed. This review discusses the chemical conjugation of antibiotics to polymers, achieved by forming covalent bonds between antibiotics and a pre-existing polymer or by developing novel antibiotic-containing polymers. Through conjugating antibiotics to polymers, unique polymer properties can be taken advantage of. These polymeric antibiotics display controlled, sustained drug release and vary in antibiotic class type, synthetic method, polymer composition, bond lability, and antibacterial activity. The polymer synthesis, characterization, drug release, and antibacterial activities, if applicable, will be presented to offer a detailed overview of each system. PMID:24751888

Biological adaptive control model: a mechanical analogue of multi-factorial bone density adaptation.

PubMed

Davidson, Peter L; Milburn, Peter D; Wilson, Barry D

2004-03-21

The mechanism of how bone adapts to every day demands needs to be better understood to gain insight into situations in which the musculoskeletal system is perturbed. This paper offers a novel multi-factorial mathematical model of bone density adaptation which combines previous single-factor models in a single adaptation system as a means of gaining this insight. Unique aspects of the model include provision for interaction between factors and an estimation of the relative contribution of each factor. This interacting system is considered analogous to a Newtonian mechanical system and the governing response equation is derived as a linear version of the adaptation process. The transient solution to sudden environmental change is found to be exponential or oscillatory depending on the balance between cellular activation and deactivation frequencies.

Unique Migraine Subtypes, Rare Headache Disorders, and Other Disturbances.

PubMed

Goadsby, Peter J

2015-08-01

The medical aphorism that common things happen commonly makes unique (and less common) migraine subtypes especially appropriate to review for the general neurologist. This article also identifies some rare headache disorders and other disturbances, and offers strategies to manage them. This article discusses migraine with brainstem aura, which is troublesome clinically and has had a change in terminology in the International Classification of Headache Disorders, Third Edition, beta version (ICHD-3 beta), and hemiplegic migraine, which is also troublesome in practice. The rare headache disorder hypnic headache and the exploding head syndrome are also discussed. When hypnic headache is recognized, it is eminently treatable, while exploding head syndrome is a benign condition with no reported consequences. Unique migraine subtypes, rare headache disorders, and other disturbances present to neurologists. When recognized, they can often be managed very well, which offers significant benefits to patients and practice satisfaction to neurologists.

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies*

PubMed Central

Young, Kimberly A.; Liu, Yan; Wang, Zuoxin

2008-01-01

The formation and maintenance of social bonds in adulthood is an essential component of human health. However studies investigating the underlying neurobiology of such behaviors have been scarce. Microtine rodents offer a unique comparative animal model to explore the neural processes responsible for pair bonding and its associated behaviors. Studies using monogamous prairie voles and other related species have recently offered insight into the neuroanatomical, neurobiological, and neurochemical underpinnings of social attachment. In this review, we will discuss the utility of the microtine rodents in comparative studies by exploring their natural history and social behavior in the laboratory. We will then summarize the data implicating vasopressin, oxytocin, and dopamine in the regulation of pair bonding. Finally, we will discuss the ways in which these neurochemical systems may interact to mediate this complex behavior. PMID:18417423

Diagnostics in the Extendable Integrated Support Environment (EISE)

NASA Technical Reports Server (NTRS)

Brink, James R.; Storey, Paul

1988-01-01

Extendable Integrated Support Environment (EISE) is a real-time computer network consisting of commercially available hardware and software components to support systems level integration, modifications, and enhancement to weapons systems. The EISE approach offers substantial potential savings by eliminating unique support environments in favor of sharing common modules for the support of operational weapon systems. An expert system is being developed that will help support diagnosing faults in this network. This is a multi-level, multi-expert diagnostic system that uses experiential knowledge relating symptoms to faults and also reasons from structural and functional models of the underlying physical model when experiential reasoning is inadequate. The individual expert systems are orchestrated by a supervisory reasoning controller, a meta-level reasoner which plans the sequence of reasoning steps to solve the given specific problem. The overall system, termed the Diagnostic Executive, accesses systems level performance checks and error reports, and issues remote test procedures to formulate and confirm fault hypotheses.

TEXSYS. [a knowledge based system for the Space Station Freedom thermal control system test-bed

NASA Technical Reports Server (NTRS)

Bull, John

1990-01-01

The Systems Autonomy Demonstration Project has recently completed a major test and evaluation of TEXSYS, a knowledge-based system (KBS) which demonstrates real-time control and FDIR for the Space Station Freedom thermal control system test-bed. TEXSYS is the largest KBS ever developed by NASA and offers a unique opportunity for the study of technical issues associated with the use of advanced KBS concepts including: model-based reasoning and diagnosis, quantitative and qualitative reasoning, integrated use of model-based and rule-based representations, temporal reasoning, and scale-up performance issues. TEXSYS represents a major achievement in advanced automation that has the potential to significantly influence Space Station Freedom's design for the thermal control system. An overview of the Systems Autonomy Demonstration Project, the thermal control system test-bed, the TEXSYS architecture, preliminary test results, and thermal domain expert feedback are presented.

Nanocellulose-stabilized Pickering emulsions and their applications

PubMed Central

Fujisawa, Shuji; Togawa, Eiji; Kuroda, Katsushi

2017-01-01

Abstract Pickering emulsion, which is an emulsion stabilized by solid particles, offers a wide range of potential applications because it generally provides a more stable system than surfactant-stabilized emulsion. Among various solid stabilizers, nanocellulose may open up new opportunities for future Pickering emulsions owing to its unique nanosizes, amphiphilicity, and other favorable properties (e.g. chemical stability, biodegradability, biocompatibility, and renewability). In this review, the preparation and properties of nanocellulose-stabilized Pickering emulsions are summarized. We also provide future perspectives on their applications, such as drug delivery, food, and composite materials. PMID:29383046

Lessons learned for improving spacecraft ground operations

NASA Astrophysics Data System (ADS)

Bell, Michael; Stambolian, Damon; Henderson, Gena

NASA has a unique history in processing the Space Shuttle fleet for launches. Some of this experience has been captured in the NASA Lessons Learned Information System (LLIS). This tool provides a convenient way for design engineers to review lessons from the past to prevent problems from reoccurring and incorporate positive lessons in new designs. At the Kennedy Space Center, the LLIS is being used to design ground support equipment for the next generation of launch and crewed vehicles. This paper describes the LLIS process and offers some examples.

Mass sensing based on deterministic and stochastic responses of elastically coupled nanocantilevers.

PubMed

Gil-Santos, Eduardo; Ramos, Daniel; Jana, Anirban; Calleja, Montserrat; Raman, Arvind; Tamayo, Javier

2009-12-01

Coupled nanomechanical systems and their entangled eigenstates offer unique opportunities for the detection of ultrasmall masses. In this paper we show theoretically and experimentally that the stochastic and deterministic responses of a pair of coupled nanocantilevers provide different and complementary information about the added mass of an analyte and its location. This method allows the sensitive detection of minute quantities of mass even in the presence of large initial differences in the active masses of the two cantilevers. Finally, we show the fundamental limits in mass detection of this sensing paradigm.

Olfactory Cued Learning Paradigm.

PubMed

Liu, Gary; McClard, Cynthia K; Tepe, Burak; Swanson, Jessica; Pekarek, Brandon; Panneerselvam, Sugi; Arenkiel, Benjamin R

2017-05-05

Sensory stimulation leads to structural changes within the CNS (Central Nervous System), thus providing the fundamental mechanism for learning and memory. The olfactory circuit offers a unique model for studying experience-dependent plasticity, partly due to a continuous supply of integrating adult born neurons. Our lab has recently implemented an olfactory cued learning paradigm in which specific odor pairs are coupled to either a reward or punishment to study downstream circuit changes. The following protocol outlines the basic set up for our learning paradigm. Here, we describe the equipment setup, programming of software, and method of behavioral training.

Advanced Microsystems for Automotive Applications 2005

NASA Astrophysics Data System (ADS)

Valldorf, Jürgen; Gessner, Wolfgang

Since 1995 the annual international forum on Advanced Microsystems for Automotive Applications (AMAA) has been held in Berlin. The event offers a unique opportunity for microsystems component developers, system suppliers and car manufacturers to show and to discuss competing technological approaches of microsystems based solutions in vehicles. The book accompanying the event has demonstrated to be an efficient instrument for the diffusion of new concepts and technology results. The present volume including the papers of the AMAA 2005 gives an overview on the state-of-the-art and outlines imminent and mid-term R&D perspectives.

Introduction to the arcopter arc wing and the Bertelsen effect for positive pitch stability and control

NASA Technical Reports Server (NTRS)

Bertelsen, W. D.

1979-01-01

A brief report, offered on a wing design, new in geometry, construction, and flight characteristics. Preliminary wind tunnel data on a three-dimensional model was well as some full-scale man-carrying test results are included. There are photos of all phases of the experiments and some figures which serve to illustrate the Bertelsen Effect, a unique focus of aerodynamic forces in the arc wing system which allows the attainment of high lift coefficients with the maintenance of pitch stability and control.

Lessons Learned for Improving Spacecraft Ground Operations

NASA Technical Reports Server (NTRS)

Bell, Michael A.; Stambolian, Damon B.; Henderson, Gena M.

2012-01-01

NASA has a unique history in processing the Space Shuttle fleet for launches. Some of this experience has been captured in the NASA Lessons Learned Information System (LLIS). This tool provides a convenient way for design engineers to review lessons from the past to prevent problems from reoccurring and incorporate positive lessons in new designs. At the Kennedy Space Center, the LLIS is being used to design ground support equipment for the next generation of launch and crewed vehicles. This paper describes the LLIS process and offers some examples.

Nanocellulose-stabilized Pickering emulsions and their applications

NASA Astrophysics Data System (ADS)

Fujisawa, Shuji; Togawa, Eiji; Kuroda, Katsushi

2017-12-01

Pickering emulsion, which is an emulsion stabilized by solid particles, offers a wide range of potential applications because it generally provides a more stable system than surfactant-stabilized emulsion. Among various solid stabilizers, nanocellulose may open up new opportunities for future Pickering emulsions owing to its unique nanosizes, amphiphilicity, and other favorable properties (e.g. chemical stability, biodegradability, biocompatibility, and renewability). In this review, the preparation and properties of nanocellulose-stabilized Pickering emulsions are summarized. We also provide future perspectives on their applications, such as drug delivery, food, and composite materials.

Complex Cloud and Radiative Processes Unfolding at the Earth's Terminator: A Unique Perspective from the Proposed Deep Space Gateway

NASA Astrophysics Data System (ADS)

Davis, A. B.; Marshak, A.

2018-02-01

The Deep Space Gateway offers a unique vantage for Earth observation using reflected sunlight: day/night or night/day terminators slowly marching across the disc. It's an opportunity to improve our understanding of clouds at that key moment in their daily cycle.

Across the Nation: Unique Delivery and Inventive Approaches

ERIC Educational Resources Information Center

Fick, Jill; McKeown, Patricia; Whiteside, Ann B.; Paneitz, Becky; Flemming, Sondra; Wolf, Toni; West-Sands, Leslie; Gray, Patricia M.; Orre, Deborah J.; Adams, Ann-Marie

2004-01-01

In this article, American Association of Community Colleges member institutions provide information on the collaborative efforts in allied health programs between their colleges and the communities they serve. These are but a fraction of the inventive and unique programs community colleges across the U.S. offer to support the health and wellness…

Improving and Accelerating Drug Development for Nervous System Disorders

PubMed Central

Pankevich, Diana E.; Altevogt, Bruce M.; Dunlop, John; Gage, Fred H.; Hyman, Steve E.

2014-01-01

Advances in the neurosciences have placed the field in the position where it is poised to significantly reduce the burden of nervous system disorders. However, drug discovery, development and translation for nervous system disorders still pose many unique challenges. The key scientific challenges can be summarized as follows: mechanisms of disease, target identification and validation, predictive models, biomarkers for patient stratification and as endpoints for clinical trials, clear regulatory pathways, reliability and reproducibility of published data, and data sharing and collaboration. To accelerate nervous system drug development the Institute of Medicine’s Forum on Neuroscience and Nervous System Disorders has hosted a series of public workshops that brought together representatives of industry, government (including both research funding and regulatory agencies), academia, and patient groups to discuss these challenges and offer potential strategies to improve the translational neuroscience. PMID:25442933

An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells.

PubMed

Xie, Yifang; Wang, Daqi; Lan, Feng; Wei, Gang; Ni, Ting; Chai, Renjie; Liu, Dong; Hu, Shijun; Li, Mingqing; Li, Dajin; Wang, Hongyan; Wang, Yongming

2017-05-24

Human pluripotent stem cells (hPSCs) represent a unique opportunity for understanding the molecular mechanisms underlying complex traits and diseases. CRISPR/Cas9 is a powerful tool to introduce genetic mutations into the hPSCs for loss-of-function studies. Here, we developed an episomal vector-based CRISPR/Cas9 system, which we called epiCRISPR, for highly efficient gene knockout in hPSCs. The epiCRISPR system enables generation of up to 100% Insertion/Deletion (indel) rates. In addition, the epiCRISPR system enables efficient double-gene knockout and genomic deletion. To minimize off-target cleavage, we combined the episomal vector technology with double-nicking strategy and recent developed high fidelity Cas9. Thus the epiCRISPR system offers a highly efficient platform for genetic analysis in hPSCs.

Unobtrusive Biometric System Based on Electroencephalogram Analysis

NASA Astrophysics Data System (ADS)

Riera, A.; Soria-Frisch, A.; Caparrini, M.; Grau, C.; Ruffini, G.

2007-12-01

Features extracted from electroencephalogram (EEG) recordings have proved to be unique enough between subjects for biometric applications. We show here that biometry based on these recordings offers a novel way to robustly authenticate or identify subjects. In this paper, we present a rapid and unobtrusive authentication method that only uses 2 frontal electrodes referenced to another one placed at the ear lobe. Moreover, the system makes use of a multistage fusion architecture, which demonstrates to improve the system performance. The performance analysis of the system presented in this paper stems from an experiment with 51 subjects and 36 intruders, where an equal error rate (EER) of 3.4% is obtained, that is, true acceptance rate (TAR) of 96.6% and a false acceptance rate (FAR) of 3.4%. The obtained performance measures improve the results of similar systems presented in earlier work.

Medical Robotic and Tele surgical Simulation Education Research

DTIC Science & Technology

2017-05-01

training exercises, DVSS = 40, dVT = 65, and RoSS = 52 for skills development. All three offer 3D visual images but use different display technologies...capabilities with an emphasis on their educational skills. They offer unique advantages and capabilities in training robotic sur- geons. Each device has been...evaluate the transfer of training effect of each simulator. Collectively, this work will offer end users and potential buyers a comparison of the value

Eight worst advertising mistakes.

PubMed

Maley, Catherine

2010-11-01

This article presents strategies for advertising the medical practice. The emphasis is on breaking out of the old rules of how one should advertise and delves into asking questions that lead to a true strategy unique to one's medical practice and offerings. The article discusses the myriad ways to think about and create a patient-centered approach, turning from "here is what we offer" to instead "what you want we offer." Copyright © 2010 Elsevier Inc. All rights reserved.

The science of neural interface systems.

PubMed

Hatsopoulos, Nicholas G; Donoghue, John P

2009-01-01

The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of neural function. Although electrical stimulation systems have already reached widespread clinical application, neural interfaces that record neural signals to decipher movement intentions are only now beginning to develop into clinically viable systems to help paralyzed people. We begin by reviewing state-of-the-art research and early-stage clinical recording systems and focus on systems that record single-unit action potentials. We then address the potential for neural interface research to enhance basic scientific understanding of brain function by offering unique insights in neural coding and representation, plasticity, brain-behavior relations, and the neurobiology of disease. Finally, we discuss technical and scientific challenges faced by these systems before they are widely adopted by severely motor-disabled patients.

Model reductions using a projection formulation

NASA Technical Reports Server (NTRS)

De Villemagne, Christian; Skelton, Robert E.

1987-01-01

A new methodology for model reduction of MIMO systems exploits the notion of an oblique projection. A reduced model is uniquely defined by a projector whose range space and orthogonal to the null space are chosen among the ranges of generalized controllability and observability matrices. The reduced order models match various combinations (chosen by the designer) of four types of parameters of the full order system associated with (1) low frequency response, (2) high frequency response, (3) low frequency power spectral density, and (4) high frequency power spectral density. Thus, the proposed method is a computationally simple substitute for many existing methods, has an extreme flexibility to embrace combinations of existing methods and offers some new features.

Nanobiotechnology and bone regeneration: a mini-review.

PubMed

Gusić, Nadomir; Ivković, Alan; VaFaye, John; Vukasović, Andreja; Ivković, Jana; Hudetz, Damir; Janković, Saša

2014-09-01

The purpose of this paper is to review current developments in bone tissue engineering, with special focus on the promising role of nanobiotechnology. This unique fusion between nanotechnology and biotechnology offers unprecedented possibilities in studying and modulating biological processes on a molecular and atomic scale. First we discuss the multiscale hierarchical structure of bone and its implication on the design of new scaffolds and delivery systems. Then we briefly present different types of nanostructured scaffolds, and finally we conclude with nanoparticle delivery systems and their potential use in promoting bone regeneration. This review is not meant to be exhaustive and comprehensive, but aims to highlight concepts and key advances in the field of nanobiotechnology and bone regeneration.

Three Views on Concurrent Enrollment. Feature on Research and Leadership. Vol. 1, No. 2

ERIC Educational Resources Information Center

Scheffel, Kent

2016-01-01

In this brief, Kent Scheffel offers a unique combination of expertise on dual credit and concurrent enrollment as he reviews questions of quality, program accreditation, and education policy for concurrent enrollment offerings from a national (National Alliance of Concurrent Enrollment Partnerships (NACEP), local (Lewis and Clark Community…

A Study of Contextualised Mobile Information Delivery for Language Learning

ERIC Educational Resources Information Center

de Jong, Tim; Specht, Marcus; Koper, Rob

2010-01-01

Mobile devices offer unique opportunities to deliver learning content in authentic learning situations. Apart from being able to play various kinds of rich multimedia content, they offer new ways of tailoring information to the learner's situation or context. This paper presents the results of a study of mobile media delivery for language…

Humanistic Wellness Services for Community Mental Health Providers

ERIC Educational Resources Information Center

Carney, Jolynn V.

2007-01-01

The author examines the unique ability of mental health providers to offer humanistic services in a highly competitive atmosphere by using a wellness approach. J. E. Myers and T. J. Sweeney's (2005) 5 second-order factors are offered as a conceptual model. Therapeutic techniques and humanizing benefits for individuals, families, and communities…

Making Departments Distinctive: The Continuous Quality Improvement (CQI) Mindset.

ERIC Educational Resources Information Center

Chambliss, Catherine

The Continuous Quality Improvement (CQI) approach has provided many corporations with a tool for adapting to ongoing shifts in demands and resources, and it can offer academic settings similar assistance. CQI offers a mechanism for building a collaborative process that can help departments define their unique strengths and cultivate a distinctive…

Fostering Experiential Learning and Service through Client Projects in Graduate Business Courses Offered Online

ERIC Educational Resources Information Center

Hagan, Linda M.

2012-01-01

Undergraduate marketing and public relations capstone courses utilize client projects to allow students to apply their knowledge and encourage collaboration. Yet, at the graduate level, especially with courses offered in an online modality, experiential service learning in the form of client project assignments presents unique challenges. However,…

Science 25. Curriculum Guide. Revised.

ERIC Educational Resources Information Center

Northwest Territories Dept. of Education, Yellowknife.

This science curriculum is an activity-oriented program in which an attempt has been made to provide sufficient information for non-science specialists to enable them to offer an effective course at the grades 10 and 11 levels. This curriculum offers a solution to the unique needs of life in the Canadian Northwest Territories. The role of…

Serving Stakeholders at a Small Regional University

ERIC Educational Resources Information Center

Burrage, Sean

2015-01-01

The Southeastern Oklahoma State University Honors Program serves a unique role in a small, rural setting such as Durant, Oklahoma. The honors program has a traditional mission in a university that offers a nontraditional setting and history within the context of higher education. The program thus offers special rewards to its students and to the…

Addressing Unison and Uniqueness of Reliability and Safety for Better Integration

NASA Technical Reports Server (NTRS)

Huang, Zhaofeng; Safie, Fayssal

2015-01-01

For a long time, both in theory and in practice, safety and reliability have not been clearly differentiated, which leads to confusion, inefficiency, and sometime counter-productive practices in executing each of these two disciplines. It is imperative to address the uniqueness and the unison of these two disciplines to help both disciplines become more effective and to promote a better integration of the two for enhancing safety and reliability in our products as an overall objective. There are two purposes of this paper. First, it will investigate the uniqueness and unison of each discipline and discuss the interrelationship between the two for awareness and clarification. Second, after clearly understanding the unique roles and interrelationship between the two in a product design and development life cycle, we offer suggestions to enhance the disciplines with distinguished and focused roles, to better integrate the two, and to improve unique sets of skills and tools of reliability and safety processes. From the uniqueness aspect, the paper identifies and discusses the respective uniqueness of reliability and safety from their roles, accountability, nature of requirements, technical scopes, detailed technical approaches, and analysis boundaries. It is misleading to equate unreliable to unsafe, since a safety hazard may or may not be related to the component, sub-system, or system functions, which are primarily what reliability addresses. Similarly, failing-to-function may or may not lead to hazard events. Examples will be given in the paper from aerospace, defense, and consumer products to illustrate the uniqueness and differences between reliability and safety. From the unison aspect, the paper discusses what the commonalities between reliability and safety are, and how these two disciplines are linked, integrated, and supplemented with each other to accomplish the customer requirements and product goals. In addition to understanding the uniqueness in reliability and safety, a better understanding of unison and commonalities will further help in understanding the interaction between reliability and safety. This paper discusses the unison and uniqueness of reliability and safety. It presents some suggestions for better integration of the two disciplines in terms of technical approaches, tools, techniques, and skills to enhance the role of reliability and safety in supporting a product design and development life cycle. The paper also discusses eliminating the redundant effort and minimizing the overlap of reliability and safety analyses for an efficient implementation of the two disciplines.

Fluorescent Photo-conversion: A second chance to label unique cells

PubMed Central

Mellott, Adam J.; Shinogle, Heather E.; Moore, David S.; Detamore, Michael S.

2014-01-01

Not all cells behave uniformly after treatment in tissue engineering studies. In fact, some treated cells display no signs of treatment or show unique characteristics not consistent with other treated cells. What if the “unique” cells could be isolated from a treated population, and further studied? Photo-convertible reporter proteins, such as Dendra2, allow for the ability to selectively identify unique cells with a secondary label within a primary labeled treated population. In the current study, select cells were identified and labeled through photo-conversion of Dendra2-transfected human Wharton's Jelly cells (hWJCs) for the first time. Robust photo-conversion of green-to-red fluorescence was achieved consistently in arbitrarily selected cells, allowing for precise cell identification of select hWJCs. The current study demonstrates a method that offers investigators the opportunity to selectively label and identify unique cells within a treated population for further study or isolation from the treatment population. Photo-convertible reporter proteins, such as Dendra2, offer the ability over non-photo-convertible reporter proteins, such as green fluorescent protein, to analyze unique individual cells within a treated population, which allows investigators to gain more meaningful information on how a treatment affects all cells within a target population. PMID:25914756

CNAV: A Unique Approach to a Web-Based College Information Navigator at Gettysburg College.

ERIC Educational Resources Information Center

Martys, Michael; Redman, Don; Huff, Alice; Czar, Dave; Mullane, Pat; Bennett, Joseph; Getty, Robert

In 1997, Gettysburg College (Pennsylvania) deployed the CNAV (College Navigation) Web tool to allow the students' and the entire college community the ability to better navigate through its college's curricular, co-curricular, and extracurricular offerings. CNAV is unique because, rather than treating the Web as a series of static pages, it treats…

Is God Coming to Campus Too? Thoughts on the Distinctive Features of Adventist Higher Education

ERIC Educational Resources Information Center

Andreason, Niels-Erik

2005-01-01

In this, the first of a series of short essays which explore the unique ethos embraced and advanced by different Christian denominations in their schools, Andreasen argues the necessity of Christian colleges and universities offering their students a unique, distinctive Christian perspective throughout their learning experience rather than some…

Photo-Elicitation and Visual Semiotics: A Unique Methodology for Studying Inclusion for Children with Disabilities

ERIC Educational Resources Information Center

Stockall, Nancy

2013-01-01

The methodology in this paper discusses the use of photographs as an elicitation strategy that can reveal the thinking processes of participants in a qualitatively rich manner. Photo-elicitation techniques combined with a Piercian semiotic perspective offer a unique method for creating a frame of action for later participant analysis. Illustrative…

Generating unique IDs from patient identification data using security models

PubMed Central

Mohammed, Emad A.; Slack, Jonathan C.; Naugler, Christopher T.

2016-01-01

Background: The use of electronic health records (EHRs) has continued to increase within healthcare systems in the developed and developing nations. EHRs allow for increased patient safety, grant patients easier access to their medical records, and offer a wealth of data to researchers. However, various bioethical, financial, logistical, and information security considerations must be addressed while transitioning to an EHR system. The need to encrypt private patient information for data sharing is one of the foremost challenges faced by health information technology. Method: We describe the usage of the message digest-5 (MD5) and secure hashing algorithm (SHA) as methods for encrypting electronic medical data. In particular, we present an application of the MD5 and SHA-1 algorithms in encrypting a composite message from private patient information. Results: The results show that the composite message can be used to create a unique one-way encrypted ID per patient record that can be used for data sharing. Conclusion: The described software tool can be used to share patient EMRs between practitioners without revealing patients identifiable data. PMID:28163977

Telepsychotherapy and the Therapeutic Relationship: Principles, Advantages, and Case Examples.

PubMed

Kocsis, Barbara J; Yellowlees, Peter

2018-05-01

As the use of technology continues to expand within our mental healthcare system, there has been an increasing interest in conducting psychotherapy online using videoconferencing. Literature pertaining to telepsychotherapy has explored possible drawbacks of this modality on the therapeutic relationship, although several studies have shown that the efficacy of online psychotherapy is equivalent to in-person approaches. Little is written about the potential advantages to the psychotherapeutic relationship when psychotherapy is carried out over videoconferencing. The available literature was reviewed, as were the general principles of telepsychotherapy and the therapeutic relationship, followed by a more in-depth consideration of patient populations for whom telepsychotherapy may offer distinct advantages. The current literature, as well as our own clinical experience, suggests that telepsychotherapy may be effective for a broad range of patients, and it may offer distinct advantages in the building of a trusting psychotherapeutic relationship. Telepsychotherapy offers a novel way to reach and form strong psychotherapeutic relationships with many different types of patients, and it may foster therapeutic intimacy in ways that in-person psychotherapy cannot. More research is needed to further explore this unique modality.

Endoscopic Ultrasound-Guided Vascular Therapy: The Present and the Future

PubMed Central

Hall, Philip S.J.; Teshima, Christopher; May, Gary R.; Mosko, Jeffrey D.

2017-01-01

Endoscopic ultrasound (EUS) offers access to many intra-abdominal vessels that until now have only been accessible to the surgeon and interventional radiologist. In addition to assisting with diagnostics, this unique access offers the potential for therapeutic intervention for a host of indications. To date, this has had the most clinical impact in the treatment of gastroesophageal varices, with EUS-guided coil and glue application growing in use worldwide. Although randomised controlled trial data is lacking, we discuss the growing body of literature behind EUS-guided therapy in the management of varices. EUS has also been used in specialized centres to assist in non-variceal gastrointestinal bleeding. The treatment of bleeding from Dieulafoy lesions, tumours and pancreatic pseudoaneurysms has all been described. The potential applications of EUS have also extended to the placement of portal vein stents and porto-systemic shunts in animal models. As medicine continues to move to increasingly less invasive interventions, EUS-guided therapies offer substantial promise for the safe and effective delivery of targeted treatment for a widening array of vascular disorders. PMID:28391673

Commercial products that convey personal health information in emergencies.

PubMed

Potini, Vishnu C; Weerasuriya, Dilani N; Lowery-North, Douglas W; Kellermann, Arthur L

2011-12-01

Describe commercially available products and services designed to convey personal health information in emergencies. The search engine Google®, supplemented by print ads, was used to identify companies and organizations that offer relevant products and services to the general market. Disease-specific, health system, and health plan-specific offerings were excluded. Vendor web sites were the primary sources of information, supplemented by telephone and e-mail queries to sales representatives. Perfect inter-rater agreement was achieved. Thirty-nine unique vendors were identified. Eight sell engraved jewelry. Three offer an embossed card or pamphlet. Twelve supply USB drives with various features. Eleven support password-protected web sites. Five maintain national call centers. Available media differed markedly with respect to capacity and accessibility. Quoted prices ranged from a one-time expenditure of $3.50 to an annual fee of $200. Associated features and annual fees varied widely. A wide range of products and services exist to help patients convey personal health information. Health care providers should be familiar with their features, so they can access the information in a disaster or emergency.

Neurophysiology of Drosophila Models of Parkinson's Disease

PubMed Central

West, Ryan J. H.; Furmston, Rebecca; Williams, Charles A. C.; Elliott, Christopher J. H.

2015-01-01

We provide an insight into the role Drosophila has played in elucidating neurophysiological perturbations associated with Parkinson's disease- (PD-) related genes. Synaptic signalling deficits are observed in motor, central, and sensory systems. Given the neurological impact of disease causing mutations within these same genes in humans the phenotypes observed in fly are of significant interest. As such we observe four unique opportunities provided by fly nervous system models of Parkinson's disease. Firstly, Drosophila models are instrumental in exploring the mechanisms of neurodegeneration, with several PD-related mutations eliciting related phenotypes including sensitivity to energy supply and vesicular deformities. These are leading to the identification of plausible cellular mechanisms, which may be specific to (dopaminergic) neurons and synapses rather than general cellular phenotypes. Secondly, models show noncell autonomous signalling within the nervous system, offering the opportunity to develop our understanding of the way pathogenic signalling propagates, resembling Braak's scheme of spreading pathology in PD. Thirdly, the models link physiological deficits to changes in synaptic structure. While the structure-function relationship is complex, the genetic tractability of Drosophila offers the chance to separate fundamental changes from downstream consequences. Finally, the strong neuronal phenotypes permit relevant first in vivo drug testing. PMID:25960916

Study on process design of partially-balanced, hydraulically lifting vertical ship lift

NASA Astrophysics Data System (ADS)

Xin, Shen; Xiaofeng, Xu; Lu, Zhang; Bing, Zhu; Fei, Li

2017-11-01

The hub ship lift in Panjin is the first navigation structure in China for the link between the inland and open seas, which adopts a novel partially-balanced, hydraulically lifting ship lift; it can meet such requirements as fast and sharp water level change in open sea, large draft of a yacht, and launching of a ship reception chamber; its balancing weight system can effectively reduce the load of the primary lifting cylinder, and optimize the force distribution of the ship reception chamber. The paper provides an introduction to main equipment, basic principles, main features and system composition of a ship lift. The unique power system and balancing system of the completed ship lift has offered some experience for the construction of the tourism-type ship lifts with a lower lifting height.

Over a barrel: corporate corruption of science and its effects on workers and the environment.

PubMed

Egilman, David S; Bohme, Susanna Rankin

2005-01-01

Although occupational and environmental diseases are often viewed as isolated and unique failures of science, the government, or industry to protect the best interest of the public, they are in fact an outcome of a pervasive system of corporate priority setting, decision making, and influence. This system produces disease because political, economic, regulatory and ideological norms prioritize values of wealth and profit over human health and environmental well-being. Science is a key part of this system; there is a substantial tradition of manipulation of evidence, data, and analysis, ultimately designed to maintain favorable conditions for industry at both material and ideological levels. This issue offers examples of how corporations influence science, shows the effects that influence has on environmental and occupational health, and provides evidence of a systemic problem.

Strategic alliances in healthcare: opportunities for the Veterans Affairs healthcare system.

PubMed

Halverson, P K; Kaluzny, A D; Young, G J

1997-01-01

Strategic alliances are proving to be effective strategies for responding and adapting to changing environments, and as such they offer the U.S. Department of Veterans Affairs (VA) healthcare system valuable opportunities for accomplishing the goals of its major reorganization effort. This article begins with an examination of basic strategic-alliance structures that are employed across many different types of industries. Next, consideration is given to the ways in which these basic alliance structures may be adapted to the unique organizations and individuals that serve as providers, purchasers, and consumers of health services. Finally, this article explores how models of strategic alliance in healthcare can be tailored to the specific needs and constraints of the VA healthcare system through an examination of existing and potential alliance opportunities.

NASA's Involvement in Technology Development and Transfer: The Ohio Hybrid Bus Project

NASA Technical Reports Server (NTRS)

Viterna, Larry A.

1997-01-01

A government and industry cooperative is using advanced power technology in a city transit bus that will offer double the fuel economy, and reduce emissions to one tenth of government standards. The heart of the vehicle's power system is a natural gas fueled generator unit. Power from both the generator and an advanced energy storage system is provided to a variable speed electric motor attached to the rear drive axle. A unique aspect of the vehicle's design is its use of "super" capacitors for recovery of energy during braking. This is the largest vehicle ever built using this advanced energy recovery technology. This paper describes the project goals and approach, results of its system performance modeling, and the status of the development team's effort.

Six characteristics of effective structured reporting and the inevitable integration with speech recognition.

PubMed

Liu, David; Zucherman, Mark; Tulloss, William B

2006-03-01

The reporting of radiological images is undergoing dramatic changes due to the introduction of two new technologies: structured reporting and speech recognition. Each technology has its own unique advantages. The highly organized content of structured reporting facilitates data mining and billing, whereas speech recognition offers a natural succession from the traditional dictation-transcription process. This article clarifies the distinction between the process and outcome of structured reporting, describes fundamental requirements for any effective structured reporting system, and describes the potential development of a novel, easy-to-use, customizable structured reporting system that incorporates speech recognition. This system should have all the advantages derived from structured reporting, accommodate a wide variety of user needs, and incorporate speech recognition as a natural component and extension of the overall reporting process.

Innovative paths for providing green energy for sustainable global economic growth

NASA Astrophysics Data System (ADS)

Singh, Rajendra; Alapatt, G. F.

2012-10-01

According to United Nation, world population may reach 10.1 billion by the year 2100. The fossil fuel based global economy is not sustainable. For sustainable global green energy scenario we must consider free fuel based energy conversion, environmental concerns and conservation of water. Photovoltaics (PV) offers a unique opportunity to solve the 21st century's electricity generation because solar energy is essentially unlimited and PV systems provide electricity without any undesirable impact on the environment. Innovative paths for green energy conversion and storage are proposed in areas of R and D, manufacturing and system integration, energy policy and financing. With existing silicon PV system manufacturing, the implementation of new innovative energy policies and new innovative business model can provide immediately large capacity of electricity generation to developed, emerging and underdeveloped economies.

Learning from the U.S. Department of Veterans Affairs Quality Enhancement Research Initiative: QUERI Series

PubMed Central

Graham, Ian D; Tetroe, Jacqueline

2009-01-01

As the recent collection of papers from the Quality Enhancement Research Initiative (QUERI) Series indicates, knowledge is leading to considerable action in the United States (U.S.) Department of Veterans Affairs (VA). The QUERI Series offers clinical researchers, implementation scientists, health systems, and health research funders from around the globe a unique window into the both the practice and science of implementation or knowledge translation (KT) in the VA. By describing successes and challenges as well as setbacks and disappointments, the QUERI Series is all the more useful. From the vantage point of Canadian KT researchers and officials at a national health research funding agency, we offer a number of observations and lessons that can be learned from QUERI. "Knowledge, if it does not determine action, is dead to us." Plotinus (Roman philosopher 205AD-270AD) PMID:19267920

Insights into neural crest development and evolution from genomic analysis

PubMed Central

Simões-Costa, Marcos; Bronner, Marianne E.

2013-01-01

The neural crest is an excellent model system for the study of cell type diversification during embryonic development due to its multipotency, motility, and ability to form a broad array of derivatives ranging from neurons and glia, to cartilage, bone, and melanocytes. As a uniquely vertebrate cell population, it also offers important clues regarding vertebrate origins. In the past 30 yr, introduction of recombinant DNA technology has facilitated the dissection of the genetic program controlling neural crest development and has provided important insights into gene regulatory mechanisms underlying cell migration and differentiation. More recently, new genomic approaches have provided a platform and tools that are changing the depth and breadth of our understanding of neural crest development at a “systems” level. Such advances provide an insightful view of the regulatory landscape of neural crest cells and offer a new perspective on developmental as well as stem cell and cancer biology. PMID:23817048

FVMS: A novel SiL approach on the evaluation of controllers for autonomous MAV

NASA Astrophysics Data System (ADS)

Sampaio, Rafael C. B.; Becker, Marcelo; Siqueira, Adriano A. G.; Freschi, Leonardo W.; Montanher, Marcelo P.

The originality of this work is to propose a novel SiL (Software-in-the-Loop) platform using Microsoft Flight Simulator (MSFS) to assist control design regarding the stabilization problem found in © AscTec Pelican platform. Aerial Robots Team (USP/EESC/LabRoM/ART) has developed a custom C++/C# software named FVMS (Flight Variables Management System) that interfaces the communication between the virtual Pelican and the control algorithms allowing the control designer to perform fast full closed loop real time algorithms. Emulation of embedded sensors as well as the possibility to integrate OpenCV Optical Flow algorithms to a virtual downward camera makes the SiL even more reliable. More than a strictly numeric analysis, the proposed SiL platform offers an unique experience, simultaneously offering both dynamic and graphical responses. Performance of SiL algorithms is presented and discussed.

GlobalHawk_SHOUT_ElNino

NASA Image and Video Library

2016-05-01

NASA’s autonomously flown Global Hawk aircraft flew a series of flights over the Pacific Ocean during February 2016, as part of the NOAA-led mission called Sensing Hazards Operational Unmanned Technology, or SHOUT. This year’s El Nino season offered a unique opportunity for the aircraft to contribute data directly to NOAA’s El Nino Rapid Response field campaign. The campaign is seeking to determine key mechanisms affecting El Niño's impacts on the U.S. and their implications for improving NOAA's observational systems, models and predictions. The Global Hawk aircraft offers both NASA and NOAA scientists an exclusive vantage point to observe atmospheric conditions with the plane's ability to fly at 65,000 feet for a time period up to 30 hours. These long-endurance and high-altitude observations give NOAA scientists the opportunity to see a larger picture of how atmospheric changes in the tropics are directly impacting weather activity in the Western U.S.

NASA's Space Launch System: An Evolving Capability for Exploration

NASA Technical Reports Server (NTRS)

Robinson, Kimberly F.; Hefner, Keith; Hitt, David

2015-01-01

Designed to enable human space exploration missions, including eventually landings on Mars, NASA's Space Launch System (SLS) represents a unique launch capability with a wide range of utilization opportunities, from delivering habitation systems into the "proving ground" of lunar-vicinity space to enabling high-energy transits through the outer solar system. Substantial progress has been made toward the first launch of the initial configuration of SLS, which will be able to deliver more than 70 metric tons of payload into low Earth orbit (LEO). Preparations are also underway to evolve the vehicle into more powerful configurations, culminating with the capability to deliver more than 130 metric tons to LEO. Even the initial configuration of SLS will be able to deliver greater mass to orbit than any contemporary launch vehicle, and the evolved configuration will have greater performance than the Saturn V rocket that enabled human landings on the moon. SLS will also be able to carry larger payload fairings than any contemporary launch vehicle, and will offer opportunities for co-manifested and secondary payloads. Because of its substantial mass-lift capability, SLS will also offer unrivaled departure energy, enabling mission profiles currently not possible. The basic capabilities of SLS have been driven by studies on the requirements of human deep-space exploration missions, and continue to be validated by maturing analysis of Mars mission options, including the Global Exploration Roadmap. Early collaboration with science teams planning future decadal-class missions have contributed to a greater understanding of the vehicle's potential range of utilization. As SLS draws closer to its first launch, the Program is maturing concepts for future capability upgrades, which could begin being available within a decade. These upgrades, from multiple unique payload accommodations to an upper stage providing more power for inspace propulsion, have ramifications for a variety of missions, from human exploration to robotic science.

THE RAPID GROWTH OF COMMUNITY COLLEGES AND THEIR ACCESSIBILITY IN RURAL AREAS.

ERIC Educational Resources Information Center

ELDRIDGE, DONALD A.

THE COURSE OFFERINGS IN SOME JUNIOR COLLEGES FAIL TO MEET ADEQUATELY THE UNIQUE NEEDS OF RURAL YOUTH. A STUDY IN 1964 REVEALED THAT ONLY TWENTY OF THE SEVENTY JUNIOR COLLEGES IN CALIFORNIA OFFERED TRAINING IN AGRICULTURE, ALTHOUGH THE RECENTLY PUBLISHED "DIRECTORY OF JUNIOR COLLEGES" SHOWS AN INCREASE TO SIXTY. FURTHER STATISTICS REVEAL THAT 253…

Developing Fully Online Pre-Service Music and Arts Education Courses

ERIC Educational Resources Information Center

Lierse, Sharon

2015-01-01

Charles Darwin University (CDU) offers education courses for students who want to teach in Australian schools. The university is unique due to its geographic location, proximity to Asia and its high Indigenous population compared to the rest of the country. Many courses are offered fully online including music education for pre-service teachers.…

Segment-based Mass Customization: An Exploration of a New Conceptual Marketing Framework.

ERIC Educational Resources Information Center

Jiang, Pingjun

2000-01-01

Suggests that the concept of mass customization should be seen as an integral part of market segmentation theory which offers the best way to satisfy consumers' unique needs and wants while yielding profits to companies. Proposes a new concept of "segment-based based mass customization," and offers a series of propositions which are…

Minimum Competencies for Teaching Undergraduate Sport Philosophy Courses. Guidance Document

ERIC Educational Resources Information Center

National Association for Sport and Physical Education, 2004

2004-01-01

Although sport philosophy is considered to be a sub-discipline with its own unique body of knowledge, sport philosophy is more commonly offered as a single course rather than a degree program. Therefore, these guidelines are offered specifically for the teaching of a single course at the undergraduate level. In order to be effective, the course…

Dissipative Prototyping Methods: A Manifesto

NASA Astrophysics Data System (ADS)

Beesley, P.

Taking a designer's unique perspective using examples of practice in experimental installation and digital protoyping, this manifesto acts as provocation for change and unlocking new potential by encouraging changes of perspective about the material realm. Diffusive form-language is proposed as a paradigm for architectural design. This method of design is applied through 3D printing and related digital fabrication methods, offering new qualities that can be implemented in design of realms including present earth and future interplanetary environments. A paradigm shift is encouraged by questioning conventional notions of geometry that minimize interfaces and by proposing the alternatives of maximized interfaces formed by effusive kinds of formal composition. A series of projects from the Canadian research studio of the Hylozoic Architecture group are described, providing examples of component design methods employing diffusive forms within combinations of tension-integrity structural systems integrated with hybrid metabolisms employing synthetic biology. Cultural implications are also discussed, drawing from architectural theory and natural philosophy. The conclusion of this paper suggests that the practice of diffusive prototyping can offer formative strategies contributing to design of future living systems.

Earth System Science Online: An Innovative Course for Non-traditional Students, Offered by Hampton University

NASA Astrophysics Data System (ADS)

Robinson, D. Q.; Kozusko, F.; Maggi, B. H.

2003-12-01

Hampton University (HU), a historically black university, is currently offering an innovative online course, Earth System Science Online, for teachers, future teachers, non-science undergraduate majors, and mature non-traditional students continuing their education. Supported by NASA and offered by the Interdisciplinary Science Center at HU, this course targets students interested in an asynchronous web-based learning environment. Often these students are working adults, such as those in the HU religious studies program, or undergraduate athletes who need the flexibility of taking their courses online in the evenings. Participants of this course earn three hours of science credit either graduate or undergraduate through their online explorations of the geosphere, hydrosphere, and atmosphere. The incorporation of specific problem-based case studies, allows students to investigate weather phenomena, deforestation, and the various instruments and satellite data systems that are used to collect and analyze this data. This web-based course utilizes the unique capabilities of the web allowing students to work at a self-regulated pace and at times most convenient to their schedules. The course delivers all lectures, text readings, and course assignments online. Assignments are given on a weekly basis, and participants are expected to conduct independent research that will enrich their online experience. The nature of the web allows the students to easily integrate text and graphics into their assignments and have access to their classmate's work. Participants meet online weekly and interact as a team.

A Silicon SPECT System for Molecular Imaging of the Mouse Brain.

PubMed

Shokouhi, Sepideh; Fritz, Mark A; McDonald, Benjamin S; Durko, Heather L; Furenlid, Lars R; Wilson, Donald W; Peterson, Todd E

2007-01-01

We previously demonstrated the feasibility of using silicon double-sided strip detectors (DSSDs) for SPECT imaging of the activity distribution of iodine-125 using a 300-micrometer thick detector. Based on this experience, we now have developed fully customized silicon DSSDs and associated readout electronics with the intent of developing a multi-pinhole SPECT system. Each DSSD has a 60.4 mm × 60.4 mm active area and is 1 mm thick. The strip pitch is 59 micrometers, and the readout of the 1024 strips on each side gives rise to a detector with over one million pixels. Combining four high-resolution DSSDs into a SPECT system offers an unprecedented space-bandwidth product for the imaging of single-photon emitters. The system consists of two camera heads with two silicon detectors stacked one behind the other in each head. The collimator has a focused pinhole system with cylindrical-shaped pinholes that are laser-drilled in a 250 μm tungsten plate. The unique ability to collect projection data at two magnifications simultaneously allows for multiplexed data at high resolution to be combined with lower magnification data with little or no multiplexing. With the current multi-pinhole collimator design, our SPECT system will be capable of offering high spatial resolution, sensitivity and angular sampling for small field-of-view applications, such as molecular imaging of the mouse brain.

Laser Remediation of Threats Posed by Small Orbital Debris

NASA Technical Reports Server (NTRS)

Fork, Richard L.; Rogers, Jan R.; Hovater, Mary A.

2012-01-01

The continually increasing amount of orbital debris in near Earth space poses an increasing challenge to space situational awareness. Recent collisions of spacecraft caused abrupt increases in the density of both large and small debris in near Earth space. An especially challenging class of threats is that due to the increasing density of small (1 mm to 10 cm dimension) orbital debris. This small debris poses a serious threat since: (1) The high velocity enables even millimeter dimension debris to cause serious damage to vulnerable areas of space assets, e.g., detector windows; (2) The small size and large number of debris elements prevent adequate detection and cataloguing. We have identified solutions to this threat in the form of novel laser systems and novel ways of using these laser systems. While implementation of the solutions we identify is challenging we find approaches offering threat mitigation within time frames and at costs of practical interest. We base our analysis on the unique combination of coherent light specifically structured in both space and time and applied in novel ways entirely within the vacuum of space to deorbiting small debris. We compare and contrast laser based small debris removal strategies using ground based laser systems with strategies using space based laser systems. We find laser systems located and used entirely within space offer essential and decisive advantages over groundbased laser systems.

Flowering shoots of ornamental crops as a model to study cellular and molecular aspects of plant gravitropism.

PubMed

Philosoph-Hadas, Sonia; Friedman, Haya; Meir, Shimon

2015-01-01

Flowering shoots offer a very convenient and excellent model system for in-depth study of shoot gravitropism in regular stems rather than in special aboveground organs, showing how plants cope with the force of gravity on Earth and change in orientation. Regarding the emerging notion that roots and shoots execute their gravitropic bending by different mechanisms, the use of flowering shoots offers additional confirmation for the suggested shoot-sensing mechanisms initially found in Arabidopsis. As a part of confirming this mechanism, studying this unique model system also enabled elucidation of the sequence of events operating in gravity signalling in shoots. Hence, using the system of flowering shoots provided an additional dimension to our understanding of shoot gravitropism and its hormonal regulation, which has been less advanced than root gravitropism. This is particularly important since the term "shoots" includes various aboveground organs. Hence, unlike other aboveground organs such as pulvini, the asymmetric growth in response to change in shoot orientation is accompanied in cut ornamental spikes by a continuous growth process. This chapter provides an overview of the basic methods, specifically developed or adapted from other graviresponding systems, for determining the main components which play a key role in gravistimulation signalling in flowering shoots.

Unique Datasets Collected by NOAA Hurricane Hunter Aircraft during the 2017 Atlantic Hurricane Season

NASA Astrophysics Data System (ADS)

Zawislak, J.; Reasor, P.

2017-12-01

Each year, NOAA's Atlantic Oceanographic & Meteorological Laboratory (AOML) Hurricane Research Division (HRD), in partnership with the National Hurricane Center (NHC) and NOAA's Environmental Modeling Center (EMC), operates a hurricane field program, the Intensity Forecast Experiment (IFEX). The experiment leverages the NOAA P-3 and G-IV hurricane hunter aircraft, based at NOAA's Office of Marine and Aviation Operations (OMAO) Aircraft Operations Center (AOC). The goals of IFEX are to improve understanding of physical processes in tropical cyclones (TCs), improve operational forecasts of TC intensity, structure, and rainfall by providing data into operational numerical modeling systems, and to develop and refine measurement technologies. This season the IFEX program, leveraging mainly operationally tasked EMC and NHC missions, sampled extensively Hurricanes Harvey, Irma, Jose, Maria, and Nate, as well as Tropical Storm Franklin. We will contribute to this important session by providing an overview of aircraft missions into these storms, guidance on the datasets made available from instruments onboard the P-3 and G-IV, and will offer some perspective on the science that can be addressed with these unique datasets, such as the value of those datasets towards model forecast improvement. NOAA aircraft sampled these storms during critical periods of intensification, and for Hurricanes Harvey and Irma, just prior to the devastating landfalls in the Caribbean and United States. The unique instrument suite on the P-3 offers inner core observations of the three-dimensional precipitation and vortex structure, lower troposphere (boundary layer) thermodynamic properties, and surface wind speed. In contrast, the G-IV flies at higher altitudes, sampling the environment surrounding the storms, and provides deep-tropospheric soundings from dropsondes.

Achieving meaningful use: a health system perspective.

PubMed

Bero, Cynthia L; Lee, Thomas H

2010-12-01

In 2002, Partners HealthCare (Partners) launched a strategy to accelerate the use of ambulatory electronic medical records across its network of 6000 physicians. Through focus on quality software products, creation of a system of financial incentives, and active engagement of health system leadership, Partners reached high levels of physician adoption by late 2006. Partners eventually introduced a mandate that made ambulatory electronic medical record use a requirement for all of its physicians. During this multi-year initiative, Partners also focused on the effective use of electronic medical records and introduced a series of tactics designed to optimize the use of these systems. With introduction of the meaningful-use concepts in the Health Information Technology for Economic and Clinical Health (HITECH) Act, Partners will transition its efforts toward this important national priority. Partners' experience offers some unique insights into the process of electronic medical record adoption across a large, diverse health system.

Dynamic federations: storage aggregation using open tools and protocols

NASA Astrophysics Data System (ADS)

Furano, Fabrizio; Brito da Rocha, Ricardo; Devresse, Adrien; Keeble, Oliver; Álvarez Ayllón, Alejandro; Fuhrmann, Patrick

2012-12-01

A number of storage elements now offer standard protocol interfaces like NFS 4.1/pNFS and WebDAV, for access to their data repositories, in line with the standardization effort of the European Middleware Initiative (EMI). Also the LCG FileCatalogue (LFC) can offer such features. Here we report on work that seeks to exploit the federation potential of these protocols and build a system that offers a unique view of the storage and metadata ensemble and the possibility of integration of other compatible resources such as those from cloud providers. The challenge, here undertaken by the providers of dCache and DPM, and pragmatically open to other Grid and Cloud storage solutions, is to build such a system while being able to accommodate name translations from existing catalogues (e.g. LFCs), experiment-based metadata catalogues, or stateless algorithmic name translations, also known as “trivial file catalogues”. Such so-called storage federations of standard protocols-based storage elements give a unique view of their content, thus promoting simplicity in accessing the data they contain and offering new possibilities for resilience and data placement strategies. The goal is to consider HTTP and NFS4.1-based storage elements and metadata catalogues and make them able to cooperate through an architecture that properly feeds the redirection mechanisms that they are based upon, thus giving the functionalities of a “loosely coupled” storage federation. One of the key requirements is to use standard clients (provided by OS'es or open source distributions, e.g. Web browsers) to access an already aggregated system; this approach is quite different from aggregating the repositories at the client side through some wrapper API, like for instance GFAL, or by developing new custom clients. Other technical challenges that will determine the success of this initiative include performance, latency and scalability, and the ability to create worldwide storage federations that are able to redirect clients to repositories that they can efficiently access, for instance trying to choose the endpoints that are closer or applying other criteria. We believe that the features of a loosely coupled federation of open-protocols-based storage elements will open many possibilities of evolving the current computing models without disrupting them, and, at the same time, will be able to operate with the existing infrastructures, follow their evolution path and add storage centers that can be acquired as a third-party service.

Droppin' Knowledge: Black Women's Communication and Informal Learning in an Online Community

ERIC Educational Resources Information Center

Steptoe, Leslye Carynn

2011-01-01

The experiences of black women offer a unique perspective on how life is lived at the juncture of race and gender in the United States. This case study of an online community for black women centers on the site's potentiality as an online learning community as well as a uniquely black woman's space. It also explores interrelated aspects of…

The challenge of doing science in wilderness: historical, legal, and policy context

Treesearch

Peter Landres; Judy Alderson; David J. Parsons

2003-01-01

Lands designated by Congress under the Wilderness Act of 1964 (Public Law 88-577) offer unique opportunities for social and biophysical research in areas that are relatively unmodified by modern human actions. Wilderness designation also imposes a unique set of constraints on the methods that may be used or permitted to conduct this research. For example, legislated...

Effects of unique biomedical education programs for engineers: REDEEM and ESTEEM projects.

PubMed

Matsuki, Noriaki; Takeda, Motohiro; Yamano, Masahiro; Imai, Yohsuke; Ishikawa, Takuji; Yamaguchi, Takami

2009-06-01

Current engineering applications in the medical arena are extremely progressive. However, it is rather difficult for medical doctors and engineers to discuss issues because they do not always understand one another's jargon or ways of thinking. Ideally, medical engineers should become acquainted with medicine, and engineers should be able to understand how medical doctors think. Tohoku University in Japan has managed a number of unique reeducation programs for working engineers. Recurrent Education for the Development of Engineering Enhanced Medicine has been offered as a basic learning course since 2004, and Education through Synergetic Training for Engineering Enhanced Medicine has been offered as an advanced learning course since 2006. These programs, which were developed especially for engineers, consist of interactive, modular, and disease-based lectures (case studies) and substantial laboratory work. As a result of taking these courses, all students obtained better objective outcomes, on tests, and subjective outcomes, through student satisfaction. In this article, we report on our unique biomedical education programs for engineers and their effects on working engineers.

Pandemic influenza preparedness and response in Israel: a unique model of civilian-defense collaboration.

PubMed

Kohn, Sivan; Barnett, Daniel J; Leventhal, Alex; Reznikovich, Shmuel; Oren, Meir; Laor, Danny; Grotto, Itamar; Balicer, Ran D

2010-07-01

In April 2009, the World Health Organization announced the emergence of a novel influenza A(H1N1-09) virus and in June 2009 declared the outbreak a pandemic. The value of military structures in responding to pandemic influenza has become widely acknowledged in recent years. In 2005, the Israeli Government appointed the Ministry of Defense to be in charge of national preparedness and response for a severe pandemic influenza scenario. The Israeli case offers a unique example of civilian-defense partnership where the interface between the governmental, military and civilian spheres has formed a distinctive structure. The Israeli pandemic preparedness protocols represent an example of a collaboration in which aspects of an inherently medical problem can be managed by the defense sector. Although distinctive concepts of the model are not applicable to all countries, it offers a unique forum for governments and international agencies to evaluate this interface within the context of pandemic influenza.

A unique degree program for pre-pharmacy education: An undergraduate degree in pharmaceutical sciences.

PubMed

Jafari, Mahtab

2018-02-01

Within the coming decade, the demand for well-trained pharmacists is expected to only increase, especially with the aging of the United States (US) population. To help fill this growing demand, the University of California, Irvine (UCI) aims to offer a unique pre-pharmacy degree program and has developed a Bachelor of Science (BS) degree in Pharmaceutical Sciences to help achieve this goal. In this commentary, we share our experience with our curriculum and highlight its features in an effort to encourage other institutions to enhance the learning experience of their pre-pharmacy students. The efforts of the UCI Department of Pharmaceutical Sciences has resulted in UCI being consistently ranked as one of the top feeder institutions by the Pharmacy College Application Service (PharmCAS) in recent years. The UCI Pharmaceutical Sciences Bachelor of Science offers a unique pre-pharmacy educational experience in an effort to better prepare undergraduates for the rigors of the doctorate of pharmacy curriculum. Copyright © 2017. Published by Elsevier Inc.

Microlith-based Structured Sorbent for Carbon Dioxide, Humidity, and Trace Contaminant Control in Manned Space Habitats

NASA Technical Reports Server (NTRS)

Junaedi, Christian; Roychoudhury, SUbir; Howard, David F.; Perry, Jay L.; Knox, James C.

2011-01-01

To support continued manned space exploration, the development of atmosphere revitalization systems that are lightweight, compact, durable, and power efficient is a key challenge. The systems should be adaptable for use in a variety of habitats and should offer operational functionality to either expel removed constituents or capture them for closedloop recovery. As mission durations increase and exploration goals reach beyond low earth orbit, the need for regenerable adsorption processes for continuous removal of CO2 and trace contaminants from cabin air becomes critical. Precision Combustion, Inc. (PCI) and NASA Marshall (MSFC) have been developing an Engineered Structured Sorbents (ESS) approach based on PCI s patented Microlith technology to meet the requirements of future, extended human spaceflight explorations. This technology offers the inherent performance and safety attributes of zeolite and other sorbents with greater structural integrity, regenerability, and process control, thereby providing potential durability and efficiency improvements over current state-of-the-art systems. The major advantages of the ESS explored in this study are realized through the use of metal substrates to provide structural integrity (i.e., less partition of sorbents) and enhanced thermal control during the sorption process. The Microlith technology also offers a unique internal resistive heating capability that shows potential for short regeneration time and reduced power requirement compared to conventional systems. This paper presents the design, development, and performance results of the integrated adsorber modules for removing CO2, water vapor, and trace chemical contaminants. A related effort that utilizes the adsorber modules for sorption of toxic industrial chemicals is also discussed. Finally, the development of a 4-person two-leg ESS system for continuous CO2 removal is also presented.

NASA's Space Launch System: An Evolving Capability for Exploration

NASA Technical Reports Server (NTRS)

Creech, Stephen D.; Robinson, Kimberly F.

2016-01-01

A foundational capability for international human deep-space exploration, NASA's Space Launch System (SLS) vehicle represents a new spaceflight infrastructure asset, creating opportunities for mission profiles and space systems that cannot currently be executed. While the primary purpose of SLS, which is making rapid progress towards initial launch readiness in two years, will be to support NASA's Journey to Mars, discussions are already well underway regarding other potential utilization of the vehicle's unique capabilities. In its initial Block 1 configuration, capable of launching 70 metric tons (t) to low Earth orbit (LEO), SLS will propel the Orion crew vehicle to cislunar space, while also delivering small CubeSat-class spacecraft to deep-space destinations. With the addition of a more powerful upper stage, the Block 1B configuration of SLS will be able to deliver 105 t to LEO and enable more ambitious human missions into the proving ground of space. This configuration offers opportunities for launching co-manifested payloads with the Orion crew vehicle, and a class of secondary payloads, larger than today's CubeSats. Further upgrades to the vehicle, including advanced boosters, will evolve its performance to 130 t in its Block 2 configuration. Both Block 1B and Block 2 also offer the capability to carry 8.4- or 10-m payload fairings, larger than any contemporary launch vehicle. With unmatched mass-lift capability, payload volume, and C3, SLS not only enables spacecraft or mission designs currently impossible with contemporary EELVs, it also offers enhancing benefits, such as reduced risk, operational costs and/or complexity, shorter transit time to destination or launching large systems either monolithically or in fewer components. This paper will discuss both the performance and capabilities of Space Launch System as it evolves, and the current state of SLS utilization planning.

Biomimetic microstructures for photonic and fluidic synergies

NASA Astrophysics Data System (ADS)

Vasileiou, Maria; Mpatzaka, Theodora; Alexandropoulos, Dimitris; Vainos, Nikolaos A.

2017-08-01

Nature-inspired micro- and nano-structures offer a unique platform for the development of novel synergetic systems combining photonic and microfluidic functionalities. In this context, we examine the paradigm of butterfly Vanessa cardui and develop artificial diffractive microstructures inspired by its natural designs. Softlithographic and nanoimprint protocols are developed to replicate surfaces of natural specimens. Further to their optical behavior, interphases tailored by such microstructures exhibit enhanced hydrophobic properties, as compared to their planar counterparts made of the same materials. Such synergies exploited by new design approaches pave the way to prospective optofluidic, lab-on-chip and sensing applications.

Design Features and Capabilities of the First Materials Science Research Rack

NASA Technical Reports Server (NTRS)

Pettigrew, P. J.; Lehoczky, S. L.; Cobb, S. D.; Holloway, T.; Kitchens, L.

2003-01-01

The First Materials Science Research Rack (MSRR-1) aboard the International Space Station (ISS) will offer many unique capabilities and design features to facilitate a wide range of materials science investigations. The initial configuration of MSRR-1 will accommodate two independent Experiment Modules (EMS) and provide the capability for simultaneous on-orbit processing. The facility will provide the common subsystems and interfaces required for the operation of experiment hardware and accommodate telescience capabilities. MSRR1 will utilize an International Standard Payload Rack (ISPR) equipped with an Active Rack Isolation System (ARIS) for vibration isolation of the facility.

Photobiomolecular deposition of metallic particles and films

DOEpatents

Hu, Zhong-Cheng

2005-02-08

The method of the invention is based on the unique electron-carrying function of a photocatalytic unit such as the photosynthesis system I (PSI) reaction center of the protein-chlorophyll complex isolated from chloroplasts. The method employs a photo-biomolecular metal deposition technique for precisely controlled nucleation and growth of metallic clusters/particles, e.g., platinum, palladium, and their alloys, etc., as well as for thin-film formation above the surface of a solid substrate. The photochemically mediated technique offers numerous advantages over traditional deposition methods including quantitative atom deposition control, high energy efficiency, and mild operating condition requirements.

Photobiomolecular metallic particles and films

DOEpatents

Hu, Zhong-Cheng

2003-05-06

The method of the invention is based on the unique electron-carrying function of a photocatalytic unit such as the photosynthesis system I (PSI) reaction center of the protein-chlorophyll complex isolated from chloroplasts. The method employs a photo-biomolecular metal deposition technique for precisely controlled nucleation and growth of metallic clusters/particles, e.g., platinum, palladium, and their alloys, etc., as well as for thin-film formation above the surface of a solid substrate. The photochemically mediated technique offers numerous advantages over traditional deposition methods including quantitative atom deposition control, high energy efficiency, and mild operating condition requirements.

Three-Dimensional Imaging by Self-Reference Single-Channel Digital Incoherent Holography

PubMed Central

Rosen, Joseph; Kelner, Roy

2016-01-01

Digital holography offers a reliable and fast method to image a three-dimensional scene from a single perspective. This article reviews recent developments of self-reference single-channel incoherent hologram recorders. Hologram recorders in which both interfering beams, commonly referred to as the signal and the reference beams, originate from the same observed objects are considered as self-reference systems. Moreover, the hologram recorders reviewed herein are configured in a setup of a single channel interferometer. This unique configuration is achieved through the use of one or more spatial light modulators. PMID:28757811

RNAi in the mouse: rapid and affordable gene function studies in a vertebrate system.

PubMed

Rytlewski, Julie A; Beronja, Slobodan

2015-01-01

The addition of RNA interference (RNAi) to the mammalian genomic toolbox has significantly expanded our ability to use higher-order models in studies of development and disease. The mouse, in particular, has benefited most from RNAi technology. Unique combinations of RNAi vectors and delivery methods now offer a broad platform for gene silencing in transgenic mice, enabling the design of new physiologically relevant models. The era of RNAi mice has accelerated the pace of genetic study and made high-throughput screens not only feasible but also affordable. © 2014 Wiley Periodicals, Inc.

The 2004 Transit of Venus as a Space Science Education Opportunity

NASA Astrophysics Data System (ADS)

Odenwald, S.; Mayo, L.; Vondrak, R.; Thieman, J.; Hawkins, I.; Schultz, G.

2003-12-01

We will present some of the programs and activities that NASA and its missions are preparing in order to support public and K12 education in space science and astronomy using the 2004 transit of Venus as a focal event. The upcoming transit of Venus on June 8 offers a unique opportunity to educate students and the general public about the scale of the solar system and the universe, as well as basic issues in comparative planetology. NASA's Sun-Earth Connection Education Forum is offering a number of programs to take advantage of this rare event. Among these are a live web cast from Spain of the entire transit, a series of radio and TV programs directed at students and the general public, a web cast describing extra-solar planet searches using the transit geometry, and archived observations produced by public observatories and student-operated solar viewers. The NASA/OSS Education Forums will also partner with science museums, planetaria and teachers across the country to bring the transit of Venus 'down to Earth'. In addition to offering enrichment activities in mathematics and space science, we also describe collaborations that have yielded unique historical resources including online archives of newspaper articles from the 1874 and 1882 transits. In addition, in collaboration with the Library of Congress Music Division, we have supported a modern re-orchestration of John Philip Sousa's Transit of Venus March which has not been performed since 1883. We anticipate that the transit of Venus will be a significant event of considerable public interest and curiosity, if the newspaper headlines from the transit seen in 1882 are any indication.

Grip on health: A complex systems approach to transform health care.

PubMed

van Wietmarschen, Herman A; Wortelboer, Heleen M; van der Greef, Jan

2018-02-01

This article addresses the urgent need for a transition in health care to deal with the increasing prevalence of chronic diseases and associated rapid rise of health care costs. Chronic diseases evolve and are predominantly related to lifestyle and environment. A shift is needed from a reductionist repair mode of thinking, toward a more integrated biopsychosocial way of thinking about health. The aim of this article is to discuss the opportunities that complexity science offer for transforming health care toward optimal treatment and prevention of chronic lifestyle diseases. Health and health care is discussed from a complexity science perspective. The benefits of concepts developed in the field of complexity science for stimulating transitions in health care are explored. Complexity science supports the elucidation of the essence of health processes. It provides a unique perspective on health with a focus on the relationships within networks of dynamically interacting factors and the emergence of health out of the organization of those relationships. Novel types of complexity science-based intervention strategies are being developed. The first application in practice is the integrated obesity treatment program currently piloted in the Netherlands, focusing on health awareness and healing relationships. Complexity science offers various theories and methods to capture the path toward unhealthy and healthy states, facilitating the development of a dynamic integrated biopsychosocial perspective on health. This perspective offers unique insights into health processes for patients and citizens. In addition, dynamic models driven by personal data provide simulations of health processes and the ability to detect transitions between health states. Such models are essential for aligning and reconnecting the many institutions and disciplines involved in the health care sector and evolve toward an integrated health care ecosystem. © 2016 John Wiley & Sons, Ltd.

The operation, products and promotion of waterpipe businesses in New York City, Abu Dhabi and Dubai.

PubMed

Joudrey, P J; Jasie, K A; Pykalo, L; Singer, S T; Woodin, M B; Sherman, S

2016-07-10

We evaluated the customers, operations, products and advertising of these businesses to explore the unique policy challenges created by the suppliers of waterpipes. We completed a cross-sectional survey consisting of structured site observations and in-person interviews of businesses in New York City, Abu Dhabi and Dubai identified using Google, Yelp, Timeout Dubai and Timeout Abu Dhabi and neighbourhood visits in 2014. Regular customers made up 59% of customers. Franchises or chains were 28% of businesses. Waterpipes made up 39% of sales with 87% of businesses offering food within their menu. Flavoured tobacco made up 94% of sales. Discounts were offered by 47% of businesses and 94% of businesses used advertising, often through social media. The market consists of largely independent businesses, with a large regular customer base, frequently offering diversified services beyond waterpipes. These businesses advertise using both traditional and social media. The economics of waterpipe businesses is very different from the economics of cigarettes, and unique regulatory strategies are needed to control this epidemic.

Unique Offerings of the ISS as an Earth Observing Platform

NASA Technical Reports Server (NTRS)

Cooley, Victor M.

2013-01-01

The International Space Station offers unique capabilities for earth remote sensing. An established Earth orbiting platform with abundant power, data and commanding infrastructure, the ISS has been in operation for twelve years as a crew occupied science laboratory and offers low cost and expedited concept-to-operation paths for new sensing technologies. Plug in modularity on external platforms equipped with structural, power and data interfaces standardizes and streamlines integration and minimizes risk and start up difficulties. Data dissemination is also standardized. Emerging sensor technologies and instruments tailored for sensing of regional dynamics may not be worthy of dedicated platforms and launch vehicles, but may well be worthy of ISS deployment, hitching a ride on one of a variety of government or commercial visiting vehicles. As global acceptance of the urgent need for understanding Climate Change continues to grow, the value of ISS, orbiting in Low Earth Orbit, in complementing airborne, sun synchronous polar, geosynchronous and other platform remote sensing will also grow.

A Dynamic Compliance Cervix Phantom Robot for Latent Labor Simulation.

PubMed

Luk, Michelle Jennifer; Lobb, Derek; Smith, James Andrew

2018-06-01

Physical simulation systems are commonly used in training of midwifery and obstetrics students, but none of these systems offers a dynamic compliance aspect that would make them more truly representative of cervix ripening. In this study, we introduce a unique soft robot phantom that simulates the cervix softening during the latent labor phase of birth. This proof-of-concept robotic phantom can be dilated by 1 cm and effaced by 35% through the application of a Foley catheter-like loading mechanism. Furthermore, psychophysics trials demonstrate how untrained subjects can identify hard and soft states of the phantom with specificities of 91% and 87%, respectively. Both results indicated the appropriateness for application of this soft robot technology to birth training simulators.

High power communication satellites power systems study

NASA Astrophysics Data System (ADS)

Josloff, Allan T.; Peterson, Jerry R.

1995-01-01

This paper discusses a planned study to evaluate the commercial attractiveness of high power communication satellites and assesses the attributes of both conventional photovoltaic and reactor power systems. These high power satellites can play a vital role in assuring availability of universally accessible, wide bandwidth communications, for high definition TV, super computer networks and other services. Satellites are ideally suited to provide the wide bandwidths and data rates required and are unique in the ability to provide services directly to the users. As new or relocated markets arise, satellites offer a flexibility that conventional distribution services cannot match, and it is no longer necessary to be near population centers to take advantage of the telecommunication revolution. The geopolitical implications of these substantially enhanced communications capabilities can be significant.

A survey of autonomous vision-based See and Avoid for Unmanned Aircraft Systems

NASA Astrophysics Data System (ADS)

Mcfadyen, Aaron; Mejias, Luis

2016-01-01

This paper provides a comprehensive review of the vision-based See and Avoid problem for unmanned aircraft. The unique problem environment and associated constraints are detailed, followed by an in-depth analysis of visual sensing limitations. In light of such detection and estimation constraints, relevant human, aircraft and robot collision avoidance concepts are then compared from a decision and control perspective. Remarks on system evaluation and certification are also included to provide a holistic review approach. The intention of this work is to clarify common misconceptions, realistically bound feasible design expectations and offer new research directions. It is hoped that this paper will help us to unify design efforts across the aerospace and robotics communities.

A Model Vocational High Technology in Health Care Demonstration Project. Final Performance Report.

ERIC Educational Resources Information Center

Valencia Community Coll., Orlando, FL.

A unique training program in high tech obstetrical, neonatal, and pediatric nursing care areas was designed to be offered on site at Orlando (Florida) Regional Medical/Arnold Palmer Hospital for Children and Women. The training program offered 16 different courses to 355 employees over the 18-month period of the project. A needs assessment was…

Georgia on Our Minds

ERIC Educational Resources Information Center

Skophammer, Karen

2011-01-01

Oil pastels offer many advantages. They come in a large range of hues, intensities and values, and they lend themselves to blending and shading in a unique way that no other art medium offers. They can be worked and reworked from day to day by the students without the large mess and cleanup time that oil paints require. An artist whose works are a…

UPMC's blueprint for BuILDing a high-value health care system.

PubMed

Keyser, Donna; Kogan, Jane; McGowan, Marion; Peele, Pamela; Holder, Diane; Shrank, William

2018-03-30

National-level demonstration projects and real-world studies continue to inform health care transformation efforts and catalyze implementation of value-based service delivery and payment models, though evidence generation and diffusion of learnings often occurs at a relatively slow pace. Rapid-cycle learning models, however, can help individual organizations to more quickly adapt health care innovations to meet the challenges and demands of a rapidly changing health care landscape. Integrated delivery and financing systems (IDFSs) offer a unique platform for rapid-cycle learning and innovation. Since both the provider and payer benefit from delivering care that enhances the patient experience, improves quality, and reduces cost, incentives are aligned to experiment with value-based models, enhance learning about what works and why, and contribute to solutions that can accelerate transformation. In this article, we describe how the UPMC Insurance Services Division, as part of a large IDFS, uses its Business, Innovation, Learning, and Dissemination (BuILD) model to prioritize, design, test, and refine health care innovations and accelerate learning. We provide examples of how the BuILD model offers an approach for quickly assessing the impact and value of health care transformation efforts. Lessons learned through the BuILD process will offer insights and guidance for a wide range of stakeholders whether an IDFS or independent payer-provider collaborators. Copyright © 2018 Elsevier Inc. All rights reserved.

Direct 3D-printing of cell-laden constructs in microfluidic architectures.

PubMed

Liu, Justin; Hwang, Henry H; Wang, Pengrui; Whang, Grace; Chen, Shaochen

2016-04-21

Microfluidic platforms have greatly benefited the biological and medical fields, however standard practices require a high cost of entry in terms of time and energy. The utilization of three-dimensional (3D) printing technologies has greatly enhanced the ability to iterate and build functional devices with unique functions. However, their inability to fabricate within microfluidic devices greatly increases the cost of producing several different devices to examine different scientific questions. In this work, a variable height micromixer (VHM) is fabricated using projection 3D-printing combined with soft lithography. Theoretical and flow experiments demonstrate that altering the local z-heights of VHM improved mixing at lower flow rates than simple geometries. Mixing of two fluids occurs as low as 320 μL min(-1) in VHM whereas the planar zigzag region requires a flow rate of 2.4 mL min(-1) before full mixing occurred. Following device printing, to further demonstrate the ability of this projection-based method, complex, user-defined cell-laden scaffolds are directly printed inside the VHM. The utilization of this unique ability to produce 3D tissue models within a microfluidic system could offer a unique platform for medical diagnostics and disease modeling.

Prolonged instability prior to a regime shift

USGS Publications Warehouse

Spanbauer, Trisha; Allen, Craig R.; Angeler, David G.; Eason, Tarsha; Fritz, Sherilyn C.; Garmestani, Ahjond S.; Nash, Kirsty L.; Stone, Jeffery R.

2014-01-01

Regime shifts are generally defined as the point of ‘abrupt’ change in the state of a system. However, a seemingly abrupt transition can be the product of a system reorganization that has been ongoing much longer than is evident in statistical analysis of a single component of the system. Using both univariate and multivariate statistical methods, we tested a long-term high-resolution paleoecological dataset with a known change in species assemblage for a regime shift. Analysis of this dataset with Fisher Information and multivariate time series modeling showed that there was a∼2000 year period of instability prior to the regime shift. This period of instability and the subsequent regime shift coincide with regional climate change, indicating that the system is undergoing extrinsic forcing. Paleoecological records offer a unique opportunity to test tools for the detection of thresholds and stable-states, and thus to examine the long-term stability of ecosystems over periods of multiple millennia.

The search for and analysis of direct samples of early Solar System aqueous fluids.

PubMed

Zolensky, Michael E; Bodnar, Robert J; Yurimoto, Hisayoshi; Itoh, Shoichi; Fries, Marc; Steele, Andrew; Chan, Queenie H-S; Tsuchiyama, Akira; Kebukawa, Yoko; Ito, Motoo

2017-05-28

We describe the current state of the search for direct, surviving samples of early, inner Solar System fluids-fluid inclusions in meteorites. Meteoritic aqueous fluid inclusions are not rare, but they are very tiny and their characterization is at the state of the art for most analytical techniques. Meteoritic fluid inclusions offer us a unique opportunity to study early Solar System brines in the laboratory. Inclusion-by-inclusion analyses of the trapped fluids in carefully selected samples will, in the immediate future, provide us detailed information on the evolution of fluids as they interacted with anhydrous solid materials. Thus, real data can replace calculated fluid compositions in thermochemical calculations of the evolution of water and aqueous reactions in comets, asteroids, moons and the terrestrial planets.This article is part of the themed issue 'The origin, history and role of water in the evolution of the inner Solar System'. © 2017 The Author(s).

Bipropellant propulsion with reciprocating pumps

NASA Astrophysics Data System (ADS)

Whitehead, John C.

1993-06-01

A pressure regulated gas generator rocket cycle with alternately pressurized pairs of reciprocating pumps offers thrust-on-demand operation with significantly lower inert mass than conventional spacecraft liquid propulsion systems. The operation of bipropellant feed systems with reciprocating pumps is explained, with consideration for both short and long term missions. There are several methods for startup and shutdown of this self-starting pump-fed system, with preference determined by thrust duty cycle and mission duration. Progress to date includes extensive development testing of components unique to this type of system, and several live tests with monopropellant hydrazine. Pneumatic pump control valves which render pistons and bellows automatically responsive to downstream liquid demand are significantly simpler than those described previously. A compact pumpset mounted to central liquid manifolds has a pair of oxidizer pumps pneumatically slaved to a pair of fuel pumps to reduce vibration. A warm gas pressure reducer for tank expulsion can eliminate any remaining need for inert gas storage.

The UARS and open data concept and analysis study. [upper atmosphere

NASA Technical Reports Server (NTRS)

Mittal, M.; Nebb, J.; Woodward, H.

1983-01-01

Alternative concepts for a common design for the UARS and OPEN Central Data Handling Facility (CDHF) are offered. Costs for alternative implementations of the UARS designs are presented, showing that the system design does not restrict the implementation to a single manufacturer. Processing demands on the alternative UARS CDHF implementations are then discussed. With this information at hand together with estimates for OPEN processing demands, it is shown that any shortfall in system capability for OPEN support can be remedied by either component upgrades or array processing attachments rather than a system redesign. In addition to a common system design, it is shown that there is significant potential for common software design, especially in the areas of data management software and non-user-unique production software. Archiving the CDHF data are discussed. Following that, cost examples for several modes of communications between the CDHF and Remote User Facilities are presented. Technology application is discussed.

Thermophotovoltaic power conversion systems: Current performance and future potential

DOE PAGES

Celanovic, Ivan; Bermel, Peter; Soljacic, Marin

2011-01-01

Thermophotovoltaic (TPV) systems offer a unique, solid-state approach to converting heat into electricity based on thermal radiation. TPV is particularly suitable for certain classes of power generation applications that are not well served by standard engines, such as long, remote missions where repairs are difficult, and portable generation where space and weight are at a premium. While standard thermophotovoltaics are limited in their conversion efficiency, photonic crystals can improve performance by an order of magnitude for a number of systems. While there are many potential applications, two exemplary systems are discussed: TPV μreactors for portable power generation in a mm-scalemore » form factor, and solar TPV for long-term off-grid power generation from sunlight. In both cases, photonic crystals can enable potential performance exceeding that of many other well-known technologies, such as single-junction photovoltaics.« less

D3D augmented reality imaging system: proof of concept in mammography.

PubMed

Douglas, David B; Petricoin, Emanuel F; Liotta, Lance; Wilson, Eugene

2016-01-01

The purpose of this article is to present images from simulated breast microcalcifications and assess the pattern of the microcalcifications with a technical development called "depth 3-dimensional (D3D) augmented reality". A computer, head display unit, joystick, D3D augmented reality software, and an in-house script of simulated data of breast microcalcifications in a ductal distribution were used. No patient data was used and no statistical analysis was performed. The D3D augmented reality system demonstrated stereoscopic depth perception by presenting a unique image to each eye, focal point convergence, head position tracking, 3D cursor, and joystick fly-through. The D3D augmented reality imaging system offers image viewing with depth perception and focal point convergence. The D3D augmented reality system should be tested to determine its utility in clinical practice.

A compact eyetracked optical see-through head-mounted display

NASA Astrophysics Data System (ADS)

Hua, Hong; Gao, Chunyu

2012-03-01

An eye-tracked head-mounted display (ET-HMD) system is able to display virtual images as a classical HMD does, while additionally tracking the gaze direction of the user. There is ample evidence that a fully-integrated ETHMD system offers multi-fold benefits, not only to fundamental scientific research but also to emerging applications of such technology. For instance eyetracking capability in HMDs adds a very valuable tool and objective metric for scientists to quantitatively assess user interaction with 3D environments and investigate the effectiveness of various 3D visualization technologies for various specific tasks including training, education, and augmented cognition tasks. In this paper, we present an innovative optical approach to the design of an optical see-through ET-HMD system based on freeform optical technology and an innovative optical scheme that uniquely combines the display optics with the eye imaging optics. A preliminary design of the described ET-HMD system will be presented.

Closed-Loop Optogenetic Intervention in Mice

PubMed Central

Oijala, Mikko; Soltesz, Ivan

2014-01-01

Optogenetic interventions offer novel ways of probing, in a temporally specific manner, the roles of specific cell types in neuronal network functions of awake, behaving animals. Despite the unique potential for temporally specific optogenetic interventions in disease states, a major hurdle in its broad application to unpredictable brain states in a laboratory setting is constructing a real-time responsive system. We recently created a closed-loop system for stopping spontaneous seizures in chronically epileptic mice using optogenetic intervention. This system performs with very high sensitivity and specificity, and the strategy is relevant not only to epilepsy, but can also be used to react in real time, with optogenetic or other interventions, to diverse brain states. The protocol presented here is highly modular and requires variable time to perform. We describe the basic construction of a complete system, and include our downloadable custom closed-loop detection software which can be employed for this purpose. PMID:23845961

48 CFR 12.205 - Offers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... research, review existing product literature generally available in the industry to determine its adequacy... literature from offerors of commercial items in lieu of unique technical proposals. (b) Contracting officers...

48 CFR 12.205 - Offers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... research, review existing product literature generally available in the industry to determine its adequacy... literature from offerors of commercial items in lieu of unique technical proposals. (b) Contracting officers...

48 CFR 12.205 - Offers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... research, review existing product literature generally available in the industry to determine its adequacy... literature from offerors of commercial items in lieu of unique technical proposals. (b) Contracting officers...

Hyperspectral imaging utility for transportation systems

NASA Astrophysics Data System (ADS)

Bridgelall, Raj; Rafert, J. Bruce; Tolliver, Denver

2015-03-01

The global transportation system is massive, open, and dynamic. Existing performance and condition assessments of the complex interacting networks of roadways, bridges, railroads, pipelines, waterways, airways, and intermodal ports are expensive. Hyperspectral imaging is an emerging remote sensing technique for the non-destructive evaluation of multimodal transportation infrastructure. Unlike panchromatic, color, and infrared imaging, each layer of a hyperspectral image pixel records reflectance intensity from one of dozens or hundreds of relatively narrow wavelength bands that span a broad range of the electromagnetic spectrum. Hence, every pixel of a hyperspectral scene provides a unique spectral signature that offers new opportunities for informed decision-making in transportation systems development, operations, and maintenance. Spaceborne systems capture images of vast areas in a short period but provide lower spatial resolution than airborne systems. Practitioners use manned aircraft to achieve higher spatial and spectral resolution, but at the price of custom missions and narrow focus. The rapid size and cost reduction of unmanned aircraft systems promise a third alternative that offers hybrid benefits at affordable prices by conducting multiple parallel missions. This research formulates a theoretical framework for a pushbroom type of hyperspectral imaging system on each type of data acquisition platform. The study then applies the framework to assess the relative potential utility of hyperspectral imaging for previously proposed remote sensing applications in transportation. The authors also introduce and suggest new potential applications of hyperspectral imaging in transportation asset management, network performance evaluation, and risk assessments to enable effective and objective decision- and policy-making.

Hyperswitch communication network

NASA Technical Reports Server (NTRS)

Peterson, J.; Pniel, M.; Upchurch, E.

1991-01-01

The Hyperswitch Communication Network (HCN) is a large scale parallel computer prototype being developed at JPL. Commercial versions of the HCN computer are planned. The HCN computer being designed is a message passing multiple instruction multiple data (MIMD) computer, and offers many advantages in price-performance ratio, reliability and availability, and manufacturing over traditional uniprocessors and bus based multiprocessors. The design of the HCN operating system is a uniquely flexible environment that combines both parallel processing and distributed processing. This programming paradigm can achieve a balance among the following competing factors: performance in processing and communications, user friendliness, and fault tolerance. The prototype is being designed to accommodate a maximum of 64 state of the art microprocessors. The HCN is classified as a distributed supercomputer. The HCN system is described, and the performance/cost analysis and other competing factors within the system design are reviewed.

Image Reconstruction for a Partially Collimated Whole Body PET Scanner

PubMed Central

Alessio, Adam M.; Schmitz, Ruth E.; MacDonald, Lawrence R.; Wollenweber, Scott D.; Stearns, Charles W.; Ross, Steven G.; Ganin, Alex; Lewellen, Thomas K.; Kinahan, Paul E.

2008-01-01

Partially collimated PET systems have less collimation than conventional 2-D systems and have been shown to offer count rate improvements over 2-D and 3-D systems. Despite this potential, previous efforts have not established image-based improvements with partial collimation and have not customized the reconstruction method for partially collimated data. This work presents an image reconstruction method tailored for partially collimated data. Simulated and measured sensitivity patterns are presented and provide a basis for modification of a fully 3-D reconstruction technique. The proposed method uses a measured normalization correction term to account for the unique sensitivity to true events. This work also proposes a modified scatter correction based on simulated data. Measured image quality data supports the use of the normalization correction term for true events, and suggests that the modified scatter correction is unnecessary. PMID:19096731

Image Reconstruction for a Partially Collimated Whole Body PET Scanner.

PubMed

Alessio, Adam M; Schmitz, Ruth E; Macdonald, Lawrence R; Wollenweber, Scott D; Stearns, Charles W; Ross, Steven G; Ganin, Alex; Lewellen, Thomas K; Kinahan, Paul E

2008-06-01

Partially collimated PET systems have less collimation than conventional 2-D systems and have been shown to offer count rate improvements over 2-D and 3-D systems. Despite this potential, previous efforts have not established image-based improvements with partial collimation and have not customized the reconstruction method for partially collimated data. This work presents an image reconstruction method tailored for partially collimated data. Simulated and measured sensitivity patterns are presented and provide a basis for modification of a fully 3-D reconstruction technique. The proposed method uses a measured normalization correction term to account for the unique sensitivity to true events. This work also proposes a modified scatter correction based on simulated data. Measured image quality data supports the use of the normalization correction term for true events, and suggests that the modified scatter correction is unnecessary.

Designing the framework for competency-based master of public health programs in India.

PubMed

Sharma, Kavya; Zodpey, Sanjay; Morgan, Alison; Gaidhane, Abhay; Syed, Zahiruddin Quazi; Kumar, Rajeev

2013-01-01

Competency in the practice of public health is the implicit goal of education institutions that offer master of public health (MPH) programs. With the expanding number of institutions offering courses in public health in India, it is timely to develop a common framework to ensure that graduates are proficient in critical public health. Steps such as situation assessment, survey of public health care professionals in India, and national consultation were undertaken to develop a proposed competency-based framework for MPH programs in India. The existing curricula of all 23 Indian MPH courses vary significantly in content with regard to core, concentration, and crosscutting discipline areas and course durations. The competency or learning outcome is not well defined. The findings of the survey suggest that MPH graduates in India should have competencies ranging from monitoring of health problems and epidemics in the community, applying biostatistics in public health, conducting action research, understanding social and community influence on public health developing indicators and instruments to monitor and evaluate community health programs, developing proposals, and involving community in planning, delivery, and monitoring of health programs. Competency statements were framed and mapped with domains including epidemiology, biostatistics, social and behavioral sciences, health care system, policy, planning, and financing, and environmental health sciences and a crosscutting domain that include health communication and informatics, health management and leadership, professionalism, systems thinking, and public health biology. The proposed competency-based framework for Indian MPH programs can be adapted to meet the needs of diverse, unique programs. The framework ensures the uniqueness and diversity of individual MPH programs in India while contributing to measures of overall program success.

NanoLuc: A Small Luciferase is Brightening up the Field of Bioluminescence

PubMed Central

Cai, Weibo

2016-01-01

The biomedical field has greatly benefited from the discovery of bioluminescent proteins. Currently, scientists employ bioluminescent systems for numerous biomedical applications, ranging from highly sensitive cellular assays to bioluminescence-based molecular imaging. Traditionally, these systems are based on Firefly and Renilla luciferases; however, the applicability of these enzymes is limited by their size, stability, and luminescence efficiency. NanoLuc (NLuc), a novel bioluminescence platform, offers several advantages over established systems, including enhanced stability, smaller size, and >150-fold increase in luminescence. In addition, the substrate for NLuc displays enhanced stability and lower background activity, opening up new possibilities in the field of bioluminescence imaging. The NLuc system is incredibly versatile and may be utilized for a wide array of applications. The increased sensitivity, high stability, and small size of the NLuc system have the potential to drastically change the field of reporter assays in the future. However, as with all such technology, NLuc has limitations (including a non-ideal emission for in vivo applications and its unique substrate) which may cause it to find restricted use in certain areas of molecular biology. As this unique technology continues to broaden, NLuc may have a significant impact in both preclinical and clinical fields, with potential roles in disease detection, molecular imaging, and therapeutic monitoring. This review will present the NLuc technology to the scientific community in a non-biased manner, allowing the audience to adopt their own views of this novel system. PMID:27045664

Rotaxane and catenane host structures for sensing charged guest species.

PubMed

Langton, Matthew J; Beer, Paul D

2014-07-15

CONSPECTUS: The promise of mechanically interlocked architectures, such as rotaxanes and catenanes, as prototypical molecular switches and shuttles for nanotechnological applications, has stimulated an ever increasing interest in their synthesis and function. The elaborate host cavities of interlocked structures, however, can also offer a novel approach toward molecular recognition: this Account describes the use of rotaxane and catenane host systems for binding charged guest species, and for providing sensing capability through an integrated optical or electrochemical reporter group. Particular attention is drawn to the exploitation of the unusual dynamic properties of interlocked molecules, such as guest-induced shuttling or conformational switching, as a sophisticated means of achieving a selective and functional sensor response. We initially survey interlocked host systems capable of sensing cationic guests, before focusing on our accomplishments in synthesizing rotaxanes and catenanes designed for the more challenging task of selective anion sensing. In our group, we have developed the use of discrete anionic templation to prepare mechanically interlocked structures for anion recognition applications. Removal of the anion template reveals an interlocked host system, possessing a unique three-dimensional geometrically restrained binding cavity formed between the interlocked components, which exhibits impressive selectivity toward complementary anionic guest species. By incorporating reporter groups within such systems, we have developed both electrochemical and optical anion sensors which can achieve highly selective sensing of anionic guests. Transition metals, lanthanides, and organic fluorophores integrated within the mechanically bonded structural framework of the receptor are perturbed by the binding of the guest, with a concomitant change in the emission profile. We have also exploited the unique dynamics of interlocked hosts by demonstrating that an anion-induced conformational change can be used as a means of signal transduction. Electrochemical sensing has been realized by integration of the redox-active ferrocene functionality within a range of rotaxane and catenanes; binding of an anion perturbs the metallocene, leading to a cathodic shift in the ferrocene/ferrocenium redox couple. In order to obtain practical sensors for target charged guest species, confinement of receptors at a surface is necessary in order to develop robust, reuseable devices. Surface confinement also offers advantages over solution based receptors, including amplification of signal, enhanced guest binding thermodynamics and the negation of solubility problems. We have fabricated anion-templated rotaxanes and catenanes on gold electrode surfaces and demonstrated that the resulting mechanically bonded self-assembled monolayers are electrochemically responsive to the binding of anions, a crucial first step toward the advancement of sophisticated, highly selective, anion sensory devices. Rotaxane and catenane host molecules may be engineered to offer a superior level of molecular recognition, and the incorporation of optical or electrochemical reporter groups within these interlocked frameworks can allow for guest sensing. Advances in synthetic templation strategies has facilitated the synthesis of interlocked architectures and widened their interest as prototype molecular machines. However, their unique host-guest properties are only now beginning to be exploited as a sophisticated approach to chemical sensing. The development of functional host-guest sensory systems such as these is of great interest to the interdisciplinary field of supramolecular chemistry.

Introduction to the history and current status of evidence-based korean medicine: a unique integrated system of allopathic and holistic medicine.

PubMed

Yin, Chang Shik; Ko, Seong-Gyu

2014-01-01

Objectives. Korean medicine, an integrated allopathic and traditional medicine, has developed unique characteristics and has been active in contributing to evidence-based medicine. Recent developments in Korean medicine have not been as well disseminated as traditional Chinese medicine. This introduction to recent developments in Korean medicine will draw attention to, and facilitate, the advancement of evidence-based complementary alternative medicine (CAM). Methods and Results. The history of and recent developments in Korean medicine as evidence-based medicine are explored through discussions on the development of a national standard classification of diseases and study reports, ranging from basic research to newly developed clinical therapies. A national standard classification of diseases has been developed and revised serially into an integrated classification of Western allopathic and traditional holistic medicine disease entities. Standard disease classifications offer a starting point for the reliable gathering of evidence and provide a representative example of the unique status of evidence-based Korean medicine as an integration of Western allopathic medicine and traditional holistic medicine. Conclusions. Recent developments in evidence-based Korean medicine show a unique development in evidence-based medicine, adopting both Western allopathic and holistic traditional medicine. It is expected that Korean medicine will continue to be an important contributor to evidence-based medicine, encompassing conventional and complementary approaches.

Synthetic biology of cyanobacteria: unique challenges and opportunities

PubMed Central

Berla, Bertram M.; Saha, Rajib; Immethun, Cheryl M.; Maranas, Costas D.; Moon, Tae Seok; Pakrasi, Himadri B.

2013-01-01

Photosynthetic organisms, and especially cyanobacteria, hold great promise as sources of renewably-produced fuels, bulk and specialty chemicals, and nutritional products. Synthetic biology tools can help unlock cyanobacteria's potential for these functions, but unfortunately tool development for these organisms has lagged behind that for S. cerevisiae and E. coli. While these organisms may in many cases be more difficult to work with as “chassis” strains for synthetic biology than certain heterotrophs, the unique advantages of autotrophs in biotechnology applications as well as the scientific importance of improved understanding of photosynthesis warrant the development of these systems into something akin to a “green E. coli.” In this review, we highlight unique challenges and opportunities for development of synthetic biology approaches in cyanobacteria. We review classical and recently developed methods for constructing targeted mutants in various cyanobacterial strains, and offer perspective on what genetic tools might most greatly expand the ability to engineer new functions in such strains. Similarly, we review what genetic parts are most needed for the development of cyanobacterial synthetic biology. Finally, we highlight recent methods to construct genome-scale models of cyanobacterial metabolism and to use those models to measure properties of autotrophic metabolism. Throughout this paper, we discuss some of the unique challenges of a diurnal, autotrophic lifestyle along with how the development of synthetic biology and biotechnology in cyanobacteria must fit within those constraints. PMID:24009604

Forensic Evaluation of Deaf Individuals: Challenges and Strategies.

PubMed

Pollard, Robert Q; Berlinski, Brian T

2017-01-01

Forensic evaluation of deaf individuals presents unique challenges due to many examinees' fund of information deficits, potential for language deprivation, and examiners' frequent lack of creativity regarding communication methods. This article describes challenges most frequently encountered in competency to stand trial and criminal responsibility evaluations and offers strategies for overcoming them. The value of employing multiple communication methods, especially the use of illustrations, is emphasized. Suggestions also are offered regarding preparing evaluation reports and effectively communicating "key deaf fundamentals" to legal personnel. Encouragement is offered for qualified, sign-fluent professionals to engage in forensic work.

A Real-Time and Hands-On Research Course in Protein Purification and Characterization: Purification and Crystal Growth of Human Inosine Triphosphate Pyrophosphatase

ERIC Educational Resources Information Center

Kreiling, Jodi L.; Brader, Kerry; Kolar, Carol; Borgstahl, Gloria E. O.

2011-01-01

A new lecture/laboratory course to offer advanced biochemical training for undergraduate and early graduate students has been developed in the Department of Chemistry at the University of Nebraska at Omaha. This unique course offers students an opportunity to work hands-on with modern instrumentation not normally found in a predominately…

Infinium HumanMethylation450 BeadChip

Cancer.gov

The HumanMethylation450 BeadChip offers a unique combination of comprehensive, expert-selected coverage and high throughput at a low price, making it ideal for screening large sample populations such as those used in genome-wide association study cohorts. By providing quantitative methylation measurement at the single-CpG–site level for normal and FFPE samples, this assay offers powerful resolution for understanding epigenetic changes.

Unique Challenges to Preventing Perinatal HIV Transmission among Hispanic Women in California: Results of a Needs Assessment

ERIC Educational Resources Information Center

Kropp, Rhonda Y.; Montgomery, Elizabeth T.; Hill, David W.; Ruiz, Juan D.; Maldonado, Yvonne A.

2005-01-01

To identify rates and factors associated with timely prenatal care (PNC) initiation, HIV test counseling, test offering, and test offer acceptance, we conducted a semistructured survey of a convenience sample of pregnant/recently delivered Hispanic women (n = 453, 418 with analyzable data) in four California counties in 2000. Only 68.4% and 43.5%…

Mechanistic insights into the luminescent sensing of organophosphorus chemical warfare agents and simulants using trivalent lanthanide complexes.

PubMed

Dennison, Genevieve H; Johnston, Martin R

2015-04-20

Organophosphorus chemical warfare agents (OP CWAs) are potent acetylcholinesterase inhibitors that can cause incapacitation and death within minutes of exposure, and furthermore are largely undetectable by the human senses. Fast, efficient, sensitive and selective detection of these compounds is therefore critical to minimise exposure. Traditional molecular-based sensing approaches have exploited the chemical reactivity of the OP CWAs, whereas more recently supramolecular-based approaches using non-covalent interactions have gained momentum. This is due, in part, to the potential development of sensors with second-generation properties, such as reversibility and multifunction capabilities. Supramolecular sensors also offer opportunities for incorporation of metal ions allowing for the exploitation of their unique properties. In particular, trivalent lanthanide ions are being increasingly used in the OP CWA sensing event and their use in supramolecular sensors is discussed in this Minireview. We focus on the fundamental interactions of simple lanthanide systems with OP CWAs and simulants, along with the development of more elaborate and complex systems including those containing nanotubes, polymers and gold nanoparticles. Whilst literature investigations into lanthanide-based OP CWA detection systems are relatively scarce, their unique and versatile properties provide a promising platform for the development of more efficient and complex sensing systems into the future. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Clinical EPR: Unique Opportunities and Some Challenges

PubMed Central

Swartz, Harold M.; Williams, Benjamin B.; Zaki, Bassem I.; Hartford, Alan C.; Jarvis, Lesley A.; Chen, Eunice; Comi, Richard J.; Ernstoff, Marc S.; Hou, Huagang; Khan, Nadeem; Swarts, Steven G.; Flood, Ann B.; Kuppusamy, Periannan

2014-01-01

Electron paramagnetic resonance (EPR) spectroscopy has been well established as a viable technique for measurement of free radicals and oxygen in biological systems, from in vitro cellular systems to in vivo small animal models of disease. However, the use of EPR in human subjects in the clinical setting, although attractive for a variety of important applications such as oxygen measurement, is challenged with several factors including the need for instrumentation customized for human subjects, probe and regulatory constraints. This paper describes the rationale and development of the first clinical EPR systems for two important clinical applications, namely, measurement of tissue oxygen (oximetry), and radiation dose (dosimetry) in humans. The clinical spectrometers operate at 1.2 GHz frequency and use surface loop resonators capable of providing topical measurements up to 1 cm depth in tissues. Tissue pO2 measurements can be carried out noninvasively and repeatedly after placement of an oxygen-sensitive paramagnetic material (currently India ink) at the site of interest. Our EPR dosimetry system is capable of measuring radiation-induced free radicals in the tooth of irradiated human subjects to determine the exposure dose. These developments offer potential opportunities for clinical dosimetry and oximetry, which include guiding therapy for individual patients with tumors or vascular disease, by monitoring of tissue oxygenation. Further work is in progress to translate this unique technology to routine clinical practice. PMID:24439333

Coupling control based on Adiabatic elimination for densely integrated nano-photonics

NASA Astrophysics Data System (ADS)

Mrejen, Michael; Suchowski, Haim; Hatakeyama, Taiki; Wu, Chihhui; Feng, Liang; O'Brien, Kevin; Wang, Yuan; Zhang, Xiang

2015-03-01

The ever growing need for energy-efficient and fast communications is driving the development of highly integrated photonic circuits where controlling light at the nanoscale becomes the most critical aspect of information transfer. Here we develop a unique scheme of adiabatic elimination (AE) modulation to actively control the coupling among waveguides for densely integrated photonics. Analogous to atomic systems, AE is achieved by applying a decomposition on a three waveguide coupler, where the two outer waveguides serve as an effective two-mode system with an effective coupling of Veff = [(V*13 + V*23V*12/Δβ12) (V13-V23V12/Δβ23) ]1/2,and the middle waveguide is the equivalent to the intermediate level `dark state'. We experimentally demonstrate the first all optical AE modulation and its ability to control the coupling between the two waveguides by manipulating the mode index of the decoupled middle one. In addition, we show that the strong modes interactions allowed at the nano-scale offer a unique configuration of zero-coupling between all the waveguides, a phenomena that paves the way for ultra-high density photonic integrated circuits where small footprint is of crucial importance.

Investigating the predictive validity of implicit and explicit measures of motivation in problem-solving behavioural tasks.

PubMed

Keatley, David; Clarke, David D; Hagger, Martin S

2013-09-01

Research into the effects of individuals'autonomous motivation on behaviour has traditionally adopted explicit measures and self-reported outcome assessment. Recently, there has been increased interest in the effects of implicit motivational processes underlying behaviour from a self-determination theory (SDT) perspective. The aim of the present research was to provide support for the predictive validity of an implicit measure of autonomous motivation on behavioural persistence on two objectively measurable tasks. SDT and a dual-systems model were adopted as frameworks to explain the unique effects offered by explicit and implicit autonomous motivational constructs on behavioural persistence. In both studies, implicit autonomous motivation significantly predicted unique variance in time spent on each task. Several explicit measures of autonomous motivation also significantly predicted persistence. Results provide support for the proposed model and the inclusion of implicit measures in research on motivated behaviour. In addition, implicit measures of autonomous motivation appear to be better suited to explaining variance in behaviours that are more spontaneous or unplanned. Future implications for research examining implicit motivation from dual-systems models and SDT approaches are outlined. © 2012 The British Psychological Society.

Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells.

PubMed

Hadland, Brandon; Yoshimoto, Momoko

2018-04-01

In adult hematopoiesis, the hematopoietic stem cell (HSC) sits at the top of a hierarchy of hematopoietic progenitors responsible for generating the diverse repertoire of blood and immune cells. During embryonic development, however, the initial waves of hematopoiesis provide the first functioning blood cells of the developing embryo, such as primitive erythrocytes arising in the yolk sac, independently of HSCs. In the field of developmental immunology, it has been recognized that some components of the immune system, such as B-1a lymphocytes, are uniquely produced during the embryonic and neonatal period, suggesting a "layered" development of immunity. Several recent studies have shed new light on the developmental origin of the layered immune system, suggesting complex and sometimes multiple contributions to unique populations of innate-like immune cells from both fetal HSCs and earlier HSC-independent progenitors. In this review, we will attempt to synthesize these studies to provide an integrated model of developmental hematopoiesis and layered immunity that may offer new insights into the origin of HSCs. Copyright © 2018 ISEH – Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

The Steris Reliance EPS endoscope processing system: a new automated endoscope reprocessing technology.

PubMed

2007-01-01

In this Evaluation, we examine whether the Steris Reliance EPS--a flexible endoscope reprocessing system that was recently introduced to the U.S. market--offers meaningful advantages over "traditional" automated endoscope reprocessors (AERs). Most AERs on the market function similarly to one another. The Reliance EPS, however, includes some unique features that distinguish it from other AERs. For example, it incorporates a "boot" technology for loading the endoscopes into the unit without requiring a lot of endoscope-specific connectors, and it dispenses the germicide used to disinfect the endoscopes from a single-use container. This Evaluation looks at whether the unique features of this model make it a better choice than traditional AERs for reprocessing flexible endoscopes. Our study focuses on whether the Reliance EPS is any more likely to be used correctly-thereby reducing the likelihood that an endoscope will be reprocessed inadequately-and whether the unit possesses any design flaws that could lead to reprocessing failures. We detail the unit's advantages and disadvantages compared with other AERs, and we describe what current users have to say. Our conclusions will help facilities determine whether to select the Reliance EPS.

Salmonella Strains Isolated from Galápagos Iguanas Show Spatial Structuring of Serovar and Genomic Diversity

PubMed Central

Lankau, Emily W.; Cruz Bedon, Lenin; Mackie, Roderick I.

2012-01-01

It is thought that dispersal limitation primarily structures host-associated bacterial populations because host distributions inherently limit transmission opportunities. However, enteric bacteria may disperse great distances during food-borne outbreaks. It is unclear if such rapid long-distance dispersal events happen regularly in natural systems or if these events represent an anthropogenic exception. We characterized Salmonella enterica isolates from the feces of free-living Galápagos land and marine iguanas from five sites on four islands using serotyping and genomic fingerprinting. Each site hosted unique and nearly exclusive serovar assemblages. Genomic fingerprint analysis offered a more complex model of S. enterica biogeography, with evidence of both unique strain pools and of spatial population structuring along a geographic gradient. These findings suggest that even relatively generalist enteric bacteria may be strongly dispersal limited in a natural system with strong barriers, such as oceanic divides. Yet, these differing results seen on two typing methods also suggests that genomic variation is less dispersal limited, allowing for different ecological processes to shape biogeographical patterns of the core and flexible portions of this bacterial species' genome. PMID:22615968

In Vivo Confocal Microscopy of Corneal Nerves in Health and Disease

PubMed Central

Cruzat, Andrea; Qazi, Yureeda; Hamrah, Pedram

2016-01-01

In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal physiology and disease. Enabling the dissection of corneal architecture at a cellular level, this technique offers fast and noninvasive in vivo imaging of the cornea with images comparable to that of ex vivo histochemical techniques. Corneal nerves bear substantial relevance to clinicians and scientists alike, given their pivotal roles in regulation of corneal sensation, maintenance of epithelial integrity, and proliferation and promotion of wound healing. Thus, IVCM offers a unique method to study corneal nerve alterations in a myriad of conditions, such as ocular and systemic diseases and following corneal surgery, without altering the tissue microenvironment. Of particular interest has been the correlation of corneal subbasal nerves to their function, which has been studied in normal eyes, contact lens wearers, and patients with keratoconus, infectious keratitis, corneal dystrophies, and neurotrophic keratopathy. Longitudinal studies have applied IVCM to investigate the effects of corneal surgery on nerves, demonstrating their regenerative capacity. IVCM is increasingly important in the diagnosis and management of systemic conditions such as peripheral diabetic neuropathy and, more recently, in ocular diseases. In this review, we outline the principles and applications of IVCM in the study of corneal nerves in various ocular and systemic diseases. PMID:27771327

Supercritical fluid processing: a new dry technique for photoresist developing

NASA Astrophysics Data System (ADS)

Gallagher-Wetmore, Paula M.; Wallraff, Gregory M.; Allen, Robert D.

1995-06-01

Supercritical fluid (SCF) technology is investigated as a dry technique for photoresist developing. Because of their unique combination of gaseous and liquid-like properties, these fluids offer comparative or improved efficiencies over liquid developers and, particularly carbon dioxide, would have tremendous beneficial impact on the environment and on worker safety. Additionally, SCF technology offers the potential for processing advanced resist systems which are currently under investigation as well as those that may have been abandoned due to problems associated with conventional developers. An investigation of various negative and positive photoresist systems is ongoing. Initially, supercritical carbon dioxide (SC CO2) as a developer for polysilane resists was explored because the exposure products, polysiloxanes, are generally soluble in this fluid. These initial studies demonstrated the viability of the SCF technique with both single layer and bilayer systems. Subsequently, the investigation focused on using SC CO2 to produce negative images with polymers that would typically be considered positive resists. Polymers such as styrenes and methacrylates were chemically modified by fluorination and/or copolymerization to render them soluble in SC CO2. Siloxane copolymers and siloxane-modified methacrylates were examined as well. The preliminary findings reported here indicate the feasibility of using SC CO2 for photoresist developing.

Unique IL-13Rα2-based HIV-1 vaccine strategy to enhance mucosal immunity, CD8(+) T-cell avidity and protective immunity.

PubMed

Ranasinghe, C; Trivedi, S; Stambas, J; Jackson, R J

2013-11-01

We have established that mucosal immunization can generate high-avidity human immunodeficiency virus (HIV)-specific CD8(+) T cells compared with systemic immunization, and interleukin (IL)-13 is detrimental to the functional avidity of these T cells. We have now constructed two unique recombinant HIV-1 vaccines that co-express soluble or membrane-bound forms of the IL-13 receptor α2 (IL-13Rα2), which can "transiently" block IL-13 activity at the vaccination site causing wild-type animals to behave similar to an IL-13 KO animal. Following intranasal/intramuscular prime-boost immunization, these IL-13Rα2-adjuvanted vaccines have shown to induce (i) enhanced HIV-specific CD8(+) T cells with higher functional avidity, with broader cytokine/chemokine profiles and greater protective immunity using a surrogate mucosal HIV-1 challenge, and also (ii) excellent multifunctional mucosal CD8(+) T-cell responses, in the lung, genito-rectal nodes (GN), and Peyer's patch (PP). Data revealed that intranasal delivery of these IL-13Rα2-adjuvanted HIV vaccines recruited large numbers of unique antigen-presenting cell subsets to the lung mucosae, ultimately promoting the induction of high-avidity CD8(+) T cells. We believe our novel IL-13R cytokine trap vaccine strategy offers great promise for not only HIV-1, but also as a platform technology against range of chronic infections that require strong sustained high-avidity mucosal/systemic immunity for protection.

A guide to transportation enhancements

DOT National Transportation Integrated Search

2004-12-01

The Federal Transportation Enhancement Program offers extensive opportunities to take unique and creative actions to integrate transportation into our communities and the natural environment. Transportation enhancement activities can be stand-alone p...

The National Practice Benchmark for Oncology: 2015 Report for 2014 Data

PubMed Central

Balch, Carla; Ogle, John D.

2016-01-01

The National Practice Benchmark (NPB) is a unique tool used to measure oncology practices against others across the country in a meaningful way despite variations in practice demographics, size, and setting. In today’s challenging economic environment, each practice positions service offerings and competitive advantages to attract patients. Although the data in the NPB report are primarily reported by community oncology practices, the business structure and arrangements with regional health care systems are also reflected in the benchmark report. The ability to produce detailed metrics is an accomplishment of excellence in business and clinical management. With these metrics, a practice should be able to measure and analyze its current business practices and make appropriate changes, if necessary. In this report, we build on the foundation initially established by Oncology Metrics (acquired by Flatiron Health in 2014) over years of data collection and refine definitions to deliver the NPB, which is uniquely meaningful in the oncology market. PMID:27006357

Heliophysical Explorers (HELEX): Solar Orbiter and Sentinels - Report of the Joint Science and Technology Definition Team (JSTDT)

NASA Technical Reports Server (NTRS)

2008-01-01

Heliophysical Explorers (HELEX) brings together and augments the unique capabilities of ESA's Solar Orbiter mission (near-Sun and out-of-ecliptic in-situ plus remote-sensing observations) with those of NASA's Inner Heliospheric Sentinels (in-situ observations from multiple platforms arrayed at varying radial distances and azimuthal locations in the near-ecliptic plane)to investigate, characterize, and understand how the Sun determines the environment of the inner solar system and, more broadly, generates the heliosphere itself. This joint ESA-NASA science program offers a unique opportunity for coordinated, correlative measurements, resulting in a combined observational capability and science return that far outweighs that of either mission alone. Building on the knowledge gained from missions like Helios and Ulysses, and STEREO, HELEX will bring to bear the power of multipoint, in-situ measurements using previously unavailable instrumental capabilities in combination with remote-sensing observations from a new, inner heliospheric perspective to answer fundamental questions about the Sun-heliosphere linkage.

Surface phononic graphene

NASA Astrophysics Data System (ADS)

Yu, Si-Yuan; Sun, Xiao-Chen; Ni, Xu; Wang, Qing; Yan, Xue-Jun; He, Cheng; Liu, Xiao-Ping; Feng, Liang; Lu, Ming-Hui; Chen, Yan-Feng

2016-12-01

Strategic manipulation of wave and particle transport in various media is the key driving force for modern information processing and communication. In a strongly scattering medium, waves and particles exhibit versatile transport characteristics such as localization, tunnelling with exponential decay, ballistic, and diffusion behaviours due to dynamical multiple scattering from strong scatters or impurities. Recent investigations of graphene have offered a unique approach, from a quantum point of view, to design the dispersion of electrons on demand, enabling relativistic massless Dirac quasiparticles, and thus inducing low-loss transport either ballistically or diffusively. Here, we report an experimental demonstration of an artificial phononic graphene tailored for surface phonons on a LiNbO3 integrated platform. The system exhibits Dirac quasiparticle-like transport, that is, pseudo-diffusion at the Dirac point, which gives rise to a thickness-independent temporal beating for transmitted pulses, an analogue of Zitterbewegung effects. The demonstrated fully integrated artificial phononic graphene platform here constitutes a step towards on-chip quantum simulators of graphene and unique monolithic electro-acoustic integrated circuits.

Observations and modeling of the ionospheric gravity and diamagnetic current systems from CHAMP and Swarm measurements

NASA Astrophysics Data System (ADS)

Alken, P.

2016-01-01

The CHAMP and Swarm satellites, which provide high-quality magnetic field measurements in low-altitude polar orbits, are ideally suited for investigating ionospheric current systems. In this study, we focus on the F region low-latitude gravity and diamagnetic currents which are prominent in the equatorial ionization anomaly (EIA) region in the North and South Hemisphere. During its 10 year mission, CHAMP has sampled nearly the entire altitude range of the EIA, offering the opportunity to study these currents from above, inside, and below their source region. The Swarm constellation offers the unique opportunity to study near-simultaneous measurements of the current systems at different longitudinal separations. In this study, we present new observations of these current systems, investigate their seasonal and local time dependence, investigate the use of in situ electron density measurements as a proxy for the magnetic perturbations, and compute the longitudinal self correlation of these currents. We find that these currents are strongest during spring and fall, produce nighttime magnetic fields at satellite altitude of up to 5-7 nT during solar maximum, 2-3 nT during solar minimum, and are highly correlated with in situ electron density measurements. We also find these currents are self-correlated above 70% up to 15° longitude in both hemispheres during the evening.

Nanotechnology: Opportunities and Challenges

NASA Technical Reports Server (NTRS)

Meyyappan, Meyya

2003-01-01

Nanotechnology seeks to exploit novel physical, chemical, biological, mechanical, electrical, and other properties, which arise primarily due to the nanoscale nature of certain materials. A key example is carbon nanotubes (CNTs) which exhibit unique electrical and extraordinary mechanical properties and offer remarkable potential for revolutionary applications in electronics devices, computing, and data storage technology, sensors, composites, nanoelectromechanical systems (NEMS), and as tip in scanning probe microscopy (SPM) for imaging and nanolithography. Thus the CNT synthesis, characterization, and applications touch upon all disciplines of science and engineering. This presentation will provide an overview and progress report on this and other major research candidates in Nanotechnology and address opportunities and challenges ahead.

Tuning topological phases in the XMnSb2 system via chemical substitution from first principles

NASA Astrophysics Data System (ADS)

Griffin, Sinead M.; Neaton, Jeffrey B.

New Dirac materials are sought for their interesting fundamental physics and for their potential technological applications. Protected symmetries offer a route to potential zero mass Dirac and Weyl fermions, and can lead unique transport properties and spectroscopic signatures. In this work, we use first-principles calculations to study the XMnSb2 family of materials and show how varying X changes the nature of bulk protected topological features in their electronic structure. We further discuss new design rules for predicting new topological materials suggested by our calculations. SG is supported by the Early Postdoc Mobility Fellowship of the SNF.

Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics.

PubMed

Liu, Xiaoxuan; Liu, Cheng; Catapano, Carlo V; Peng, Ling; Zhou, Jiehua; Rocchi, Palma

2014-01-01

RNAi-based nucleic acid molecules have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available. Dendrimers are emerging as appealing nanocarriers for nucleic acid delivery thanks to their unique well-defined architecture and the resulting cooperativity and multivalency confined within a nanostructure. The present review offers a brief overview of the structurally flexible triethanolamine-core poly(amidoamine) (PAMAM) dendrimers developed in our group as nanovectors for the delivery of RNAi therapeutics. Their excellent activity for delivering different RNAi therapeutics in various disease models in vitro and in vivo will be highlighted here. © 2013.

Native American health: traditional healing and culturally competent health care internet resources.

PubMed

Carlock, Danielle

2006-01-01

Health disparities between Native Americans and the general population of the United States are a major health concern. Traditional healing and culturally competent health care offer much promise in raising the health status of Native Americans. Traditional healing, although uniquely practiced by each indigenous culture, is generally a system of medicine based on the inseparability of mind, body, and spirit. Culturally competent health care, care that is congruent with the culture and language of the patient, is a growing initiative in western medicine. This article outlines Internet sites and online resources relevant to the study and practice of traditional healing and culturally competent health care.

High Precision Piezoelectric Linear Motors for Operations at Cryogenic Temperatures and Vacuum

NASA Technical Reports Server (NTRS)

Wong, D.; Carman, G.; Stam, M.; Bar-Cohen, Y.; Sen, A.; Henry, P.; Bearman, G.; Moacanin, J.

1995-01-01

The Jet Propulsion Laboratory evaluated the use of an electromechanical device for optically positioning a mirror system during the pre-project phase of the Pluto-Fast-Flyby (PFF) mission. The device under consideration was a piezoelectric driven linear motor functionally dependent upon a time varying electric field which induces displacements ranging from submicrons to millimeters with positioning accuracy within nanometers. Using a control package, the mirror system provides image motion compensation and mosaicking capabilities. While this device offers unique advantages, there were concerns pertaining to its operational capabilities for the PFF mission. The issues include irradiation effects and thermal concerns. A literature study indicated that irradiation effects will not significantly impact the linear motor's operational characteristics. On the other hand, thermal concerns necessitated an in depth study.

Controlled surface-induced flows from the motion of self-assembled colloidal walkers.

PubMed

Sing, Charles E; Schmid, Lothar; Schneider, Matthias F; Franke, Thomas; Alexander-Katz, Alfredo

2010-01-12

Biological flows at the microscopic scale are important for the transport of nutrients, locomotion, and differentiation. Here, we present a unique approach for creating controlled, surface-induced flows inspired by a ubiquitous biological system, cilia. Our design is based on a collection of self-assembled colloidal rotors that "walk" along surfaces in the presence of a rotating magnetic field. These rotors are held together solely by magnetic forces that allow for reversible assembly and disassembly of the chains. Furthermore, rotation of the magnetic field allows for straightforward manipulation of the shape and motion of these chains. This system offers a simple and versatile approach for designing microfluidic devices as well as for studying fundamental questions in cooperative-driven motion and transport at the microscopic level.

Microbial Ecology and Evolution in the Acid Mine Drainage Model System.

PubMed

Huang, Li-Nan; Kuang, Jia-Liang; Shu, Wen-Sheng

2016-07-01

Acid mine drainage (AMD) is a unique ecological niche for acid- and toxic-metals-adapted microorganisms. These low-complexity systems offer a special opportunity for the ecological and evolutionary analyses of natural microbial assemblages. The last decade has witnessed an unprecedented interest in the study of AMD communities using 16S rRNA high-throughput sequencing and community genomic and postgenomic methodologies, significantly advancing our understanding of microbial diversity, community function, and evolution in acidic environments. This review describes new data on AMD microbial ecology and evolution, especially dynamics of microbial diversity, community functions, and population genomes, and further identifies gaps in our current knowledge that future research, with integrated applications of meta-omics technologies, will fill. Copyright © 2016 Elsevier Ltd. All rights reserved.

Overlapped Fourier coding for optical aberration removal

PubMed Central

Horstmeyer, Roarke; Ou, Xiaoze; Chung, Jaebum; Zheng, Guoan; Yang, Changhuei

2014-01-01

We present an imaging procedure that simultaneously optimizes a camera’s resolution and retrieves a sample’s phase over a sequence of snapshots. The technique, termed overlapped Fourier coding (OFC), first digitally pans a small aperture across a camera’s pupil plane with a spatial light modulator. At each aperture location, a unique image is acquired. The OFC algorithm then fuses these low-resolution images into a full-resolution estimate of the complex optical field incident upon the detector. Simultaneously, the algorithm utilizes redundancies within the acquired dataset to computationally estimate and remove unknown optical aberrations and system misalignments via simulated annealing. The result is an imaging system that can computationally overcome its optical imperfections to offer enhanced resolution, at the expense of taking multiple snapshots over time. PMID:25321982

Elusive silane-alane complex [Si-H⋅⋅⋅Al]: isolation, characterization, and multifaceted frustrated Lewis pair type catalysis.

PubMed

Chen, Jiawei; Chen, Eugene Y-X

2015-06-01

The super acidity of the unsolvated Al(C6F5)3 enabled isolation of the elusive silane-alane complex [Si-H⋅⋅⋅Al], which was structurally characterized by spectroscopic and X-ray diffraction methods. The Janus-like nature of this adduct, coupled with strong silane activation, effects multifaceted frustrated-Lewis-pair-type catalysis. When compared with the silane-borane system, the silane-alane system offers unique features or clear advantages in the four types of catalytic transformations examined in this study, including: ligand redistribution of tertiary silanes into secondary and quaternary silanes, polymerization of conjugated polar alkenes, hydrosilylation of unactivated alkenes, and hydrodefluorination of fluoroalkanes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Prokaryotic communities differ along a geothermal soil photic gradient.

PubMed

Meadow, James F; Zabinski, Catherine A

2013-01-01

Geothermal influenced soils exert unique physical and chemical limitations on resident microbial communities but have received little attention in microbial ecology research. These environments offer a model system in which to investigate microbial community heterogeneity and a range of soil ecological concepts. We conducted a 16S bar-coded pyrosequencing survey of the prokaryotic communities in a diatomaceous geothermal soil system and compared communities across soil types and along a conspicuous photic depth gradient. We found significant differences between the communities of the two different soils and also predictable differences between samples taken at different depths. Additionally, we targeted three ecologically relevant bacterial phyla, Cyanobacteria, Planctomycetes, and Verrucomicrobia, for clade-wise comparisons with these variables and found strong differences in their abundances, consistent with the autecology of these groups.

Probing Radiatively Inefficient Accretion Flow in the Neutron Star X-ray Binary System Aquila X-1

NASA Astrophysics Data System (ADS)

Maitra, Dipankar

2016-09-01

The nature of radiatively inefficient accretion flows (RIAF) near neutron stars and black holes remains largely enshrouded in mystery, primarily due to their low luminosity. Long term monitoring of Aql X-1 has revealed that during certain outbursts, the system goes into a relatively bright RIAF state for periods lasting several weeks. These low-intensity states offer a unique opportunity to probe radiatively inefficient flows. We request a 75 ksec Chandra/HETG ToO observation of Aql X-1 during a low-intensity state. Emission line diagnostics of the observed spectrum will be used to test different RIAF models and constrain flow properties such as the radial temperature and density profile, existence of an outflowing wind, spatial extent of the RIAF, and gas dynamics within the flow.

Probing Radiatively Inefficient Accretion Flow in the Neutron Star X-ray Binary System Aquila X-1

NASA Astrophysics Data System (ADS)

Maitra, Dipankar

2017-09-01

The nature of radiatively inefficient accretion flows (RIAF) near neutron stars and black holes remains largely enshrouded in mystery, primarily due to their low luminosity. Long term monitoring of Aql X-1 has revealed that during certain outbursts, the system goes into a relatively bright RIAF state for periods lasting several weeks. These low-intensity states offer a unique opportunity to probe radiatively inefficient flows. We request a 75 ksec Chandra/HETG ToO observation of Aql X-1 during a low-intensity state. Emission line diagnostics of the observed spectrum will be used to test different RIAF models and constrain flow properties such as the radial temperature and density profile, existence of an outflowing wind, spatial extent of the RIAF, and gas dynamics within the flow.

Influence of IR sensor technology on the military and civil defense

NASA Astrophysics Data System (ADS)

Becker, Latika

2006-02-01

Advances in basic infrared science and developments in pertinent technology applications have led to mature designs being incorporated in civil as well as military area defense systems. Military systems include both tactical and strategic, and civil area defense includes homeland security. Technical challenges arise in applying infrared sensor technology to detect and track targets for space and missile defense. Infrared sensors are valuable due to their passive capability, lower mass and power consumption, and their usefulness in all phases of missile defense engagements. Nanotechnology holds significant promise in the near future by offering unique material and physical properties to infrared components. This technology is rapidly developing. This presentation will review the current IR sensor technology, its applications, and future developments that will have an influence in military and civil defense applications.

Hand veins feature extraction using DT-CNNS

NASA Astrophysics Data System (ADS)

Malki, Suleyman; Spaanenburg, Lambert

2007-05-01

As the identification process is based on the unique patterns of the users, biometrics technologies are expected to provide highly secure authentication systems. The existing systems using fingerprints or retina patterns are, however, very vulnerable. One's fingerprints are accessible as soon as the person touches a surface, while a high resolution camera easily captures the retina pattern. Thus, both patterns can easily be "stolen" and forged. Beside, technical considerations decrease the usability for these methods. Due to the direct contact with the finger, the sensor gets dirty, which decreases the authentication success ratio. Aligning the eye with a camera to capture the retina pattern gives uncomfortable feeling. On the other hand, vein patterns of either a palm of the hand or a single finger offer stable, unique and repeatable biometrics features. A fingerprint-based identification system using Cellular Neural Networks has already been proposed by Gao. His system covers all stages of a typical fingerprint verification procedure from Image Preprocessing to Feature Matching. This paper performs a critical review of the individual algorithmic steps. Notably, the operation of False Feature Elimination is applied only once instead of 3 times. Furthermore, the number of iterations is limited to 1 for all used templates. Hence, the computational need of the feedback contribution is removed. Consequently the computational effort is drastically reduced without a notable chance in quality. This allows a full integration of the detection mechanism. The system is prototyped on a Xilinx Virtex II Pro P30 FPGA.

Quantum Opportunities and Challenges for Fundamental Sciences in Space

NASA Technical Reports Server (NTRS)

Yu, Nan

2012-01-01

Space platforms offer unique environment for and measurements of quantum world and fundamental physics. Quantum technology and measurements enhance measurement capabilities in space and result in greater science returns.

Use of the data system for field management of a clinical study conducted in Kolkata, India.

PubMed

Park, Ju Yeon; Kim, Deok Ryun; Haldar, Bisakha; Mallick, Aiyel Haque; Kim, Soon Ae; Dey, Ayan; Nandy, Ranjan Kumar; Paul, Dilip Kumar; Choudhury, Saugata; Sahoo, Shushama; Wierzba, Thomas F; Sur, Dipika; Kanungo, Suman; Ali, Mohammad; Manna, Byomkesh

2016-01-09

Designing an appropriate data system is important to the success of a clinical study. However, little information is available on this topic. We share our experiences on designing, developing, and implementation of a data system for management of data and field activities of a complex clinical study. The data system was implemented aiming at determining the biological basis for the underperformance of oral vaccines, such as polio and rotavirus vaccines in children at a site in Kolkata, India. The system included several functionalities to control data and field activities. It was restricted to authorized users based on their access privileges. A relational database platform was chosen, and Microsoft Visual FoxPro 7.0 (Microsoft Corporation, Seattle, WA, USA) was used to develop the system. The system was installed at the clinic and data office to facilitate both the field and data management activities. Data were doubly entered by two different data operators to identify keypunching errors in the data. Outliers, duplication, inconsistencies, missing entries, and linkage were also checked. Every modification and users log-in/log-out information was auto-recorded in an audit trail. The system offered tools for preparation of visit schedule of the participants. A visit considered as protocol deviation was documented by the system. The system alerted field staff to every upcoming visit date to organize the field activities and to inform participants which day to come. The system also produced a growth chart for evaluating nutritional status and referring the child to a specialized clinic if found to be severely malnourished. The data system offered unique features for controlling for both data and field activities, which led to minimize drop-out rates as well as protocol deviations. Such system is warranted for a successful clinical study.

Progress on 2 MW STI8 gas turbine from Pratt & Whitney Canada

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-01-01

In 1995 Pratt & Whitney Canada announced their intention to offer industrial and marine versions of the PW100 series aircraft gas turbine widely used in turboprop applications. The new ST18 gas turbine is rated in the two megawatt range for industrial and marine applications and offers an especially compact and lightweight gas turbine for this output level. As in other aeroderivative designs from Pratt & Whitney Canada, headquartered in Longueuil, Quebec, the ST18 gas turbine features a centrifugal compressor design. The two-stage centrifugal compressor, with a unique high efficiency external pipe diffuser system connecting the low pressure and high pressuremore » compressor, achieves an overall compression ratio of 15:1, with air flow of 7.7 kg/s. A relatively good thermal efficiency level of about 30% is achieved in this design. For exhaust emission control purposes, water injection in excess of a 1:1 ratio is utilized in the reverse flow annular combustion system to achieve less than 35 ppm NO{sub x} on natural gas fuel. This paper provides some of the design details of this gas turbine and changes made for the industrial and marine configuration. 4 figs.« less

High-temperature solid electrolyte interphases (SEI) in graphite electrodes

NASA Astrophysics Data System (ADS)

Rodrigues, Marco-Tulio F.; Sayed, Farheen N.; Gullapalli, Hemtej; Ajayan, Pulickel M.

2018-03-01

Thermal fragility of the solid electrolyte interphase (SEI) is a major source of performance decay in graphite anodes, and efforts to overcome the issues offered by extreme environments to Li-ion batteries have had limited success. Here, we demonstrate that the SEI can be extensively reinforced by carrying the formation cycles at elevated temperatures. Under these conditions, decomposition of the ionic liquid present in the electrolyte favored the formation of a thicker and more protective layer. Cells in which the solid electrolyte interphase was cast at 90 °C were significantly less prone to self-discharge when exposed to high temperature, with no obvious damages to the formed SEI. This additional resilience was accomplished at the expense of rate capability, as charge transfer became growingly inefficient in these systems. At slower rates, however, cells that underwent SEI formation at 90 °C presented superior performances, as a result of improved Li+ transport through the SEI, and optimal wetting of graphite by the electrolyte. This work analyzes different graphite hosts and ionic liquids, showing that this effect is more pervasive than anticipated, and offering the unique perspective that, for certain systems, temperature can actually be an asset for passivation.

A Management Model for International Participation in Space Exploration Missions

NASA Technical Reports Server (NTRS)

George, Patrick J.; Pease, Gary M.; Tyburski, Timothy E.

2005-01-01

This paper proposes an engineering management model for NASA's future space exploration missions based on past experiences working with the International Partners of the International Space Station. The authors have over 25 years of combined experience working with the European Space Agency, Japan Aerospace Exploration Agency, Canadian Space Agency, Italian Space Agency, Russian Space Agency, and their respective contractors in the design, manufacturing, verification, and integration of their elements electric power system into the United States on-orbit segment. The perspective presented is one from a specific sub-system integration role and is offered so that the lessons learned from solving issues of technical and cultural nature may be taken into account during the formulation of international partnerships. Descriptions of the types of unique problems encountered relative to interactions between international partnerships are reviewed. Solutions to the problems are offered, taking into consideration the technical implications. Through the process of investigating each solution, the important and significant issues associated with working with international engineers and managers are outlined. Potential solutions are then characterized by proposing a set of specific methodologies to jointly develop spacecraft configurations that benefits all international participants, maximizes mission success and vehicle interoperability while minimizing cost.

Ethosomes and Transfersomes: Principles, Perspectives and Practices.

PubMed

Garg, Varun; Singh, Harmanpreet; Bimbrawh, Sneha; Singh, Sachin Kumar; Gulati, Monica; Vaidya, Yogyata; Kaur, Prabhjot

2017-01-01

The success story of liposomes in the treatment of systemic infectious diseases and various carcinomas lead the scientists to the innovation of elastic vesicles to achieve similar success through transdermal route. In this direction, ethosomes and transfersomes were developed with the objective to design the vesicles that could pass through the skin. However, there is a lack of systematic review outlining the principles, method of preparation, latest advancement and applications of ethosomes and transfersomes. This review covers various aspects that would be helpful to scientists in understanding advantages of these vesicular systems and designing a unique nano vesicular delivery system. Structured search of bibliographic databases for previously published peer-reviewed research papers was explored and data was culminated in terms of principle of these vesicular delivery systems, composition, mechanism of actions, preparation techniques, methods for their characterization and their application. A total of 182 papers including both, research and review articles, were included in this review in order to make the article comprehensive and readily understandable. The mechanism of action and composition of ethosomes and transfersomes was extensively discussed. Various methods of preparation such as, rotary film evaporation method, reverse phase evaporation method, vortex/ sonication method, ethanol injection method, freeze thaw methods, along with their advantages has been discussed. It was also discussed that both these elastic nanocarriers offer unique advantages of ferrying the drug across membranes, sustaining drug release as well as protecting the encapsulated bio actives from external environment. The enhanced bioavailability and skin penetration of ethosomes as compared to conventional vesicular delivery systems is attributed to the presence of ethanol in the bilayers while that for transfersomes accrues due to their elasticity along with their ability to retain their shape because of the presence of edge activators. Successful delivery of synthetic drugs as well as phytomedicines has been extensively reported through these vesicles. Though these vesicular systems offer a good potential for rational drug delivery, a thoughtfully designed process is required to optimize the process variables involved. Industrial scale production of efficacious, safe, cost effective and stable formulations of both these delivery systems appears to be a pre-requisite to ensure their utility as the trans-dermal vehicles. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Service offerings and interfaces for the ACTS network of Earth stations

NASA Technical Reports Server (NTRS)

Coney, Thom A.

1988-01-01

The Advanced Communications Satellite (ACTS) is capable of two modes of communication. Mode 1 is a mesh network of Earth stations using baseband-switched, time-division multiple-access (BBS-TDMA) and hopping beams. Mode 2 is a mesh network using satellite-switched, time-division multiple-access (SS-TDMA) and fixed (or hopping) beams. The purpose of this paper is to present the functional requirements and the design of the ACTS Mode 1 Earth station terrestrial interface. Included among the requirements are that: (1) the interface support standard telecommunications service offerings (i.e., voice, video and data at rates ranging from 9.6 kbps to 44 Mbps); (2) the interface support the unique design characteristics of the ACTS communications systems (e.g., the real time demand assignment of satellite capacity); and (3) the interface support test hardware capable of validating ACTS communications processes. The resulting interface design makes use of an appropriate combination of T1 or T3 multiplexers and a small central office (maximum capacity 56 subscriber lines per unit).

Solutions for Hot Situations

NASA Technical Reports Server (NTRS)

2003-01-01

From the company that brought the world an integral heating and cooling food service system after originally developing it for NASA's Apollo Program, comes yet another orbital offshoot: a product that can be as thin as paper and as strong as steel. Nextel Ceramic Textiles and Composites from 3M Company offer space-age protection and innovative solutions for hot situations, ranging from NASA to NASCAR. With superior thermal protection, Nextel fabrics, tape, and sleevings outperform other high temperature textiles such as aramids, carbon, glass, and quartz, permitting engineers and manufacturers to handle applications up to 2,500 F (1,371 C). The stiffness and strength of Nextel Continuous Ceramic Fibers make them a great match for improving the rigidity of aluminum in metal matrix composites. Moreover, the fibers demonstrate low shrinkage at operating temperatures, which allow for the manufacturing of a dimensionally stable product. These novel fibers also offer excellent chemical resistance, low thermal conductivity, thermal shock resistance, low porosity, and unique electrical properties.

One-dimensional surface-imprinted polymeric nanotubes for specific biorecognition by initiated chemical vapor deposition (iCVD).

PubMed

Ince, Gozde Ozaydin; Armagan, Efe; Erdogan, Hakan; Buyukserin, Fatih; Uzun, Lokman; Demirel, Gokhan

2013-07-24

Molecular imprinting is a powerful, generic, and cost-effective technique; however, challenges still remain related to the fabrication and development of these systems involving nonhomogeneous binding sites, insufficient template removing, incompatibility with aqueous media, low rebinding capacity, and slow mass transfer. The vapor-phase deposition of polymers is a unique technique because of the conformal nature of coating and offers new possibilities in a number of applications including sensors, microfluidics, coating, and bioaffinity platforms. Herein, we demonstrated a simple but versatile concept to generate one-dimensional surface-imprinted polymeric nanotubes within anodic aluminum oxide (AAO) membranes based on initiated chemical vapor deposition (iCVD) technique for biorecognition of immunoglobulin G (IgG). It is reported that the fabricated surface-imprinted nanotubes showed high binding capacity and significant specific recognition ability toward target molecules compared with the nonimprinted forms. Given its simplicity and universality, the iCVD method can offer new possibilities in the field of molecular imprinting.

An integrated framework for the optimisation of sport and athlete development: a practitioner approach.

PubMed

Gulbin, Jason P; Croser, Morag J; Morley, Elissa J; Weissensteiner, Juanita R

2013-01-01

This paper introduces a new sport and athlete development framework that has been generated by multidisciplinary sport practitioners. By combining current theoretical research perspectives with extensive empirical observations from one of the world's leading sport agencies, the proposed FTEM (Foundations, Talent, Elite, Mastery) framework offers broad utility to researchers and sporting stakeholders alike. FTEM is unique in comparison with alternative models and frameworks, because it: integrates general and specialised phases of development for participants within the active lifestyle, sport participation and sport excellence pathways; typically doubles the number of developmental phases (n = 10) in order to better understand athlete transition; avoids chronological and training prescriptions; more optimally establishes a continuum between participation and elite; and allows full inclusion of many developmental support drivers at the sport and system levels. The FTEM framework offers a viable and more flexible alternative for those sporting stakeholders interested in managing, optimising, and researching sport and athlete development pathways.

The Gravity of High-Skilled Migration Policies.

PubMed

Czaika, Mathias; Parsons, Christopher R

2017-04-01

Combining unique, annual, bilateral data on labor flows of highly skilled immigrants for 10 OECD destinations between 2000 and 2012, with new databases comprising both unilateral and bilateral policy instruments, we present the first judicious cross-country assessment of policies aimed to attract and select high-skilled workers. Points-based systems are much more effective in attracting and selecting high-skilled migrants than requiring a job offer, labor market tests, and shortage lists. Offers of permanent residency, while attracting the highly skilled, overall reduce the human capital content of labor flows because they prove more attractive to non-high-skilled workers. Bilateral recognition of diploma and social security agreements foster greater flows of high-skilled workers and improve the skill selectivity of immigrant flows. Conversely, double taxation agreements deter high-skilled migrants, although they do not alter overall skill selectivity. Our results are robust to a variety of empirical specifications that account for destination-specific amenities, multilateral resistance to migration, and the endogeneity of immigration policies.

Growing skull hemangioma: first and unique description in a patient with Klippel-Trénaunay-Weber syndrome.

PubMed

van der Loo, Lars E; Beckervordersandforth, Jan; Colon, Albert J; Schijns, Olaf E M G

2017-02-01

We present the first and unique case of a rapid-growing skull hemangioma in a patient with Klippel-Trénaunay-Weber syndrome. This case report provides evidence that not all rapid-growing, osteolytic skull lesions need to have a malignant character but certainly need a histopathological verification. This material offers insight into the list of rare pathological diagnoses in an infrequent syndrome.

Evolution of a Reconfigurable Processing Platform for a Next Generation Space Software Defined Radio

NASA Technical Reports Server (NTRS)

Kacpura, Thomas J.; Downey, Joseph A.; Anderson, Keffery R.; Baldwin, Keith

2014-01-01

The National Aeronautics and Space Administration (NASA)Harris Ka-Band Software Defined Radio (SDR) is the first, fully reprogrammable space-qualified SDR operating in the Ka-Band frequency range. Providing exceptionally higher data communication rates than previously possible, this SDR offers in-orbit reconfiguration, multi-waveform operation, and fast deployment due to its highly modular hardware and software architecture. Currently in operation on the International Space Station (ISS), this new paradigm of reconfigurable technology is enabling experimenters to investigate navigation and networking in the space environment.The modular SDR and the NASA developed Space Telecommunications Radio System (STRS) architecture standard are the basis for Harris reusable, digital signal processing space platform trademarked as AppSTAR. As a result, two new space radio products are a synthetic aperture radar payload and an Automatic Detection Surveillance Broadcast (ADS-B) receiver. In addition, Harris is currently developing many new products similar to the Ka-Band software defined radio for other applications. For NASAs next generation flight Ka-Band radio development, leveraging these advancements could lead to a more robust and more capable software defined radio.The space environment has special considerations different from terrestrial applications that must be considered for any system operated in space. Each space mission has unique requirements that can make these systems unique. These unique requirements can make products that are expensive and limited in reuse. Space systems put a premium on size, weight and power. A key trade is the amount of reconfigurability in a space system. The more reconfigurable the hardware platform, the easier it is to adapt to the platform to the next mission, and this reduces the amount of non-recurring engineering costs. However, the more reconfigurable platforms often use more spacecraft resources. Software has similar considerations to hardware. Having an architecture standard promotes reuse of software and firmware. Space platforms have limited processor capability, which makes the trade on the amount of amount of flexibility paramount.

Ka-Band Phased Array System Characterization

NASA Technical Reports Server (NTRS)

Acosta, R.; Johnson, S.; Sands, O.; Lambert, K.

2001-01-01

Phased Array Antennas (PAAs) using patch-radiating elements are projected to transmit data at rates several orders of magnitude higher than currently offered with reflector-based systems. However, there are a number of potential sources of degradation in the Bit Error Rate (BER) performance of the communications link that are unique to PAA-based links. Short spacing of radiating elements can induce mutual coupling between radiating elements, long spacing can induce grating lobes, modulo 2 pi phase errors can add to Inter Symbol Interference (ISI), phase shifters and power divider network introduce losses into the system. This paper describes efforts underway to test and evaluate the effects of the performance degrading features of phased-array antennas when used in a high data rate modulation link. The tests and evaluations described here uncover the interaction between the electrical characteristics of a PAA and the BER performance of a communication link.

Printing Highly Controlled Suspended Carbon Nanotube Network on Micro-patterned Superhydrophobic Flexible Surface

PubMed Central

Li, Bo; Wang, Xin; Jung, Hyun Young; Kim, Young Lae; Robinson, Jeremy T.; Zalalutdinov, Maxim; Hong, Sanghyun; Hao, Ji; Ajayan, Pulickel M.; Wan, Kai-Tak; Jung, Yung Joon

2015-01-01

Suspended single-walled carbon nanotubes (SWCNTs) offer unique functionalities for electronic and electromechanical systems. Due to their outstanding flexible nature, suspended SWCNT architectures have great potential for integration into flexible electronic systems. However, current techniques for integrating SWCNT architectures with flexible substrates are largely absent, especially in a manner that is both scalable and well controlled. Here, we present a new nanostructured transfer paradigm to print scalable and well-defined suspended nano/microscale SWCNT networks on 3D patterned flexible substrates with micro- to nanoscale precision. The underlying printing/transfer mechanism, as well as the mechanical, electromechanical, and mechanical resonance properties of the suspended SWCNTs are characterized, including identifying metrics relevant for reliable and sensitive device structures. Our approach represents a fast, scalable and general method for building suspended nano/micro SWCNT architectures suitable for flexible sensing and actuation systems. PMID:26511284

Printing Highly Controlled Suspended Carbon Nanotube Network on Micro-patterned Superhydrophobic Flexible Surface.

PubMed

Li, Bo; Wang, Xin; Jung, Hyun Young; Kim, Young Lae; Robinson, Jeremy T; Zalalutdinov, Maxim; Hong, Sanghyun; Hao, Ji; Ajayan, Pulickel M; Wan, Kai-Tak; Jung, Yung Joon

2015-10-29

Suspended single-walled carbon nanotubes (SWCNTs) offer unique functionalities for electronic and electromechanical systems. Due to their outstanding flexible nature, suspended SWCNT architectures have great potential for integration into flexible electronic systems. However, current techniques for integrating SWCNT architectures with flexible substrates are largely absent, especially in a manner that is both scalable and well controlled. Here, we present a new nanostructured transfer paradigm to print scalable and well-defined suspended nano/microscale SWCNT networks on 3D patterned flexible substrates with micro- to nanoscale precision. The underlying printing/transfer mechanism, as well as the mechanical, electromechanical, and mechanical resonance properties of the suspended SWCNTs are characterized, including identifying metrics relevant for reliable and sensitive device structures. Our approach represents a fast, scalable and general method for building suspended nano/micro SWCNT architectures suitable for flexible sensing and actuation systems.

Stabilization of Model Membrane Systems by Disaccharides. Quasielastic Neutron Scattering Experiments and Atomistic Simulations

NASA Astrophysics Data System (ADS)

Doxastakis, Emmanouil; Garcia Sakai, Victoria; Ohtake, Satoshi; Maranas, Janna K.; de Pablo, Juan J.

2006-03-01

Trehalose, a disaccharide of glucose, is often used for the stabilization of cell membranes in the absence of water. This work studies the effects of trehalose on model membrane systems as they undergo a melting transition using a combination of experimental methods and atomistic molecular simulations. Quasielastic neutron scattering experiments on selectively deuterated samples provide the incoherent dynamic structure over a wide time range. Elastic scans probing the lipid tail dynamics display clear evidence of a main melting transition that is significantly lowered in the presence of trehalose. Lipid headgroup mobility is considerably restricted at high temperatures and directly associated with the dynamics of the sugar in the mixture. Molecular simulations provide a detailed overview of the dynamics and their spatial and time dependence. The combined simulation and experimental methodology offers a unique, molecular view of the physics of systems commonly employed in cryopreservation and lyophilization processes.

Restricted Authentication and Encryption for Cyber-physical Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirkpatrick, Michael S; Bertino, Elisa; Sheldon, Frederick T

2009-01-01

Cyber-physical systems (CPS) are characterized by the close linkage of computational resources and physical devices. These systems can be deployed in a number of critical infrastructure settings. As a result, the security requirements of CPS are different than traditional computing architectures. For example, critical functions must be identified and isolated from interference by other functions. Similarly, lightweight schemes may be required, as CPS can include devices with limited computing power. One approach that offers promise for CPS security is the use of lightweight, hardware-based authentication. Specifically, we consider the use of Physically Unclonable Functions (PUFs) to bind an access requestmore » to specific hardware with device-specific keys. PUFs are implemented in hardware, such as SRAM, and can be used to uniquely identify the device. This technology could be used in CPS to ensure location-based access control and encryption, both of which would be desirable for CPS implementations.« less

Acoustic Type-II Weyl Nodes from Stacking Dimerized Chains

NASA Astrophysics Data System (ADS)

Yang, Zhaoju; Zhang, Baile

2016-11-01

Lorentz-violating type-II Weyl fermions, which were missed in Weyl's prediction of nowadays classified type-I Weyl fermions in quantum field theory, have recently been proposed in condensed matter systems. The semimetals hosting type-II Weyl fermions offer a rare platform for realizing many exotic physical phenomena that are different from type-I Weyl systems. Here we construct the acoustic version of a type-II Weyl Hamiltonian by stacking one-dimensional dimerized chains of acoustic resonators. This acoustic type-II Weyl system exhibits distinct features in a finite density of states and unique transport properties of Fermi-arc-like surface states. In a certain momentum space direction, the velocity of these surface states is determined by the tilting direction of the type-II Weyl nodes rather than the chirality dictated by the Chern number. Our study also provides an approach of constructing acoustic topological phases at different dimensions with the same building blocks.

What can we learn from noise? — Mesoscopic nonequilibrium statistical physics —

PubMed Central

KOBAYASHI, Kensuke

2016-01-01

Mesoscopic systems — small electric circuits working in quantum regime — offer us a unique experimental stage to explorer quantum transport in a tunable and precise way. The purpose of this Review is to show how they can contribute to statistical physics. We introduce the significance of fluctuation, or equivalently noise, as noise measurement enables us to address the fundamental aspects of a physical system. The significance of the fluctuation theorem (FT) in statistical physics is noted. We explain what information can be deduced from the current noise measurement in mesoscopic systems. As an important application of the noise measurement to statistical physics, we describe our experimental work on the current and current noise in an electron interferometer, which is the first experimental test of FT in quantum regime. Our attempt will shed new light in the research field of mesoscopic quantum statistical physics. PMID:27477456

Human immune system mouse models of Ebola virus infection.

PubMed

Spengler, Jessica R; Prescott, Joseph; Feldmann, Heinz; Spiropoulou, Christina F

2017-08-01

Human immune system (HIS) mice, immunodeficient mice engrafted with human cells (with or without donor-matched tissue), offer a unique opportunity to study pathogens that cause disease predominantly or exclusively in humans. Several HIS mouse models have recently been used to study Ebola virus (EBOV) infection and disease. The results of these studies are encouraging and support further development and use of these models in Ebola research. HIS mice provide a small animal model to study EBOV isolates, investigate early viral interactions with human immune cells, screen vaccines and therapeutics that modulate the immune system, and investigate sequelae in survivors. Here we review existing models, discuss their use in pathogenesis studies and therapeutic screening, and highlight considerations for study design and analysis. Finally, we point out caveats to current models, and recommend future efforts for modeling EBOV infection in HIS mice. Published by Elsevier B.V.

What can we learn from noise? - Mesoscopic nonequilibrium statistical physics.

PubMed

Kobayashi, Kensuke

2016-01-01

Mesoscopic systems - small electric circuits working in quantum regime - offer us a unique experimental stage to explorer quantum transport in a tunable and precise way. The purpose of this Review is to show how they can contribute to statistical physics. We introduce the significance of fluctuation, or equivalently noise, as noise measurement enables us to address the fundamental aspects of a physical system. The significance of the fluctuation theorem (FT) in statistical physics is noted. We explain what information can be deduced from the current noise measurement in mesoscopic systems. As an important application of the noise measurement to statistical physics, we describe our experimental work on the current and current noise in an electron interferometer, which is the first experimental test of FT in quantum regime. Our attempt will shed new light in the research field of mesoscopic quantum statistical physics.

Redirecting reproductive immunology research toward pregnancy as a period of temporary immune tolerance.

PubMed

Gleicher, Norbert; Kushnir, Vitaly A; Barad, David H

2017-04-01

Referring to two recent publications, we here propose that clinical reproductive immunology has for decades stagnated because reproductive medicine, including assisted reproduction (AR), has failed to accept embryo implantation as an immune system-driven process, dependent on establishment of maternal tolerance toward the implanting fetal semi-allograft (and complete allograft in cases of oocyte donation). Pregnancy represents a biologically unique period of temporary (to the period of gestation restricted) tolerance, otherwise only known in association with parasitic infections. Rather than investigating the immune pathways necessary to induce this rather unique state of tolerance toward the rapidly growing parasitic antigen load of the fetus, the field, instead, concentrated on irrelevant secondary immune phenomena (i.e., "immunological noise"). It, therefore, does not surprise that interesting recent research, offering new potential insights into maternal tolerance during pregnancy, was mostly published outside of the field of reproductive medicine. This research offers evidence for existence of inducible maternal tolerance pathways with the ability of improving maternal fecundity and, potentially, reducing such late pregnancy complications as premature labor and preeclampsia/eclampsia due to premature abatement of maternal tolerance. Increasing evidence also suggests that tolerance-inducing immune pathways are similar in successful pregnancy, successful organ transplantation and, likely also in the tolerance of "self" (i.e., prevention of autoimmunity). Identifying and isolating these pathways, therefore, may greatly benefit all three of these clinical areas, and research in reproductive immunology should be accordingly redirected.

Marketing on a shoestring.

PubMed

Sutton, J

1999-01-01

Marketing includes the many steps taken to sell a product or service from its conception to its purchase or use. In healthcare, three cost-effective audiences to target are referring physicians and their staffs, local HMOs and PPOs, facility employees and patients. The potential users of such services--your target audience--should be made aware of new offerings such as the addition of special procedures, a new piece of equipment, or perhaps a new physician with special capabilities. To ensure a productive effort, a marketing attempt must follow two cardinal rules: first, the product or service offered must be of high quality and, second, the marketing effort must be carried out consistently. An effective marketing campaign should create an impression within the community about the facility by emphasizing those aspects of the department or facility that make it unique. Are its hours of operation adequate? Do its personnel project a professional attitude and demeanor? Does it have a specialty that makes it unique within the healthcare community? The most powerful marketing tool of all is word of mouth, which is based on the judgments clients make after visiting the facility-department or facility employees smile and greet visitors, they are polite and helpful on the telephone, their attitudes are professional, and so forth. Such impressions are worth millions in goodwill and can be used as a marketing tool. Last, an actual case study from my hospital explains how we determined the need for and marketed an open MRI system.

DTFM Modeling and Analysis Method for Gossamer Structures

NASA Technical Reports Server (NTRS)

Fang, Hou-Fei; Lou, Michael; Broduer, Steve (Technical Monitor)

2001-01-01

Gossamer systems are mostly composed of support structures formed by highly flexible, long tubular elements and pre-tensioned thin-film membranes. These systems offer order-of-magnitude reductions in mass and launch volume and will revolutionize the architecture and design of space flight systems that require large in-orbit configurations and apertures. A great interest has been generated in recent years to fly gossamer systems on near-term and future space missions. Modeling and analysis requirements for gossamer structures are unique. Simulation of in-space performance issues of gossamer structures, such as inflation deployment of flexible booms, formation and effects of wrinkle in tensioned membranes, synthesis of tubular and membrane elements into a complete structural system, usually cannot be accomplished by using the general-purpose finite-element structural analysis codes. This has led to the need of structural modeling and analysis capabilities specifically suitable for gossamer structures. The Distributed Transfer Function Method (DTFM) can potentially meet this urgent need. Additional information is contained in the original extended abstract.

Transformation in Teaching-Learning: Emerging Possibilities with Interprofessional Education.

PubMed

Yancey, Nan Russell; Cahill, Susan; McDowell, Michael

2018-04-01

As the global community continues to face increasing mobility, rising healthcare costs, and decreasing or inaccessible healthcare resources, healthcare providers must be able to work together effectively in addressing the needs of progressively older and diverse persons and populations. In this column, the notion of interprofessional education (IPE) is explored and a model proposed for implementation in an institution offering graduate programs in nursing and occupational therapy. While the proposed model was developed for two disciplinary programs in a specific institution, the recommendations offered may easily be adapted for use in academic institutions offering varied and unique healthcare professional programs.

A College Enviro-Forum

ERIC Educational Resources Information Center

Environmental Science and Technology, 1975

1975-01-01

Michigan State University faculty members plus an impressive roster of noted speakers are the elements of a unique environmental course offered by the chemical engineering department aimed at discussing pollution problems and solutions rationally. (Author/BT)

Operational Leadership in the Information Age: A New Model

DTIC Science & Technology

2000-02-08

of operational leadership and offers the individual a tool for development as well as for analyzing unique leadership situation% and thinking about the most appropriate balance of leadership styles and techniques.

New Technologies for the Diagnosis of Sleep Apnea.

PubMed

Alshaer, Hisham

2016-01-01

Sleep Apnea is a very common condition that has serious cardiovascular sequelae such as hypertension, heart failure, and stroke. Since the advent of modern computers and digital circuits, several streams of new technologies have been introduced to enhance the traditional diagnostic method of polysomnography and offer alternatives that are more accessible, comfortable, and economic. The categories presented in this review include portable polygraphy, mattress-like devices, remote sensing, and acoustic technologies. These innovations are classified as a function of their physical structure and the capabilities of their sensing technologies, due to the importance of these factors in determining the end-user experiences (both patients and medical professionals). Each of those categories offers unique strengths, which then make them particularly suitable for specific applications and end users. To our knowledge, this is a unique approach in presenting and classifying sleep apnea diagnostic innovations.

Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Northrup, Paul; Leri, Alessandra; Tappero, Ryan

The “tender” energy range of 1 to 5 keV, between the energy ranges of most “hard” (>5 keV) and “soft” (<1 keV) synchrotron X-ray facilities, offers some unique opportunities for synchrotron-based X-ray absorption fine structure spectroscopy in life sciences. In particular the K absorption edges of Na through Ca offer opportunities to study local structure, speciation, and chemistry of many important biological compounds, structures and processes. This is an area of largely untapped science, in part due to a scarcity of optimized facilities. Such measurements also entail unique experimental challenges. Lastly, this brief review describes the technique, its experimental challenges,more » recent progress in development of microbeam measurement capabilities, and several highlights illustrating applications in life sciences.« less

Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences

DOE PAGES

Northrup, Paul; Leri, Alessandra; Tappero, Ryan

2016-02-15

The “tender” energy range of 1 to 5 keV, between the energy ranges of most “hard” (>5 keV) and “soft” (<1 keV) synchrotron X-ray facilities, offers some unique opportunities for synchrotron-based X-ray absorption fine structure spectroscopy in life sciences. In particular the K absorption edges of Na through Ca offer opportunities to study local structure, speciation, and chemistry of many important biological compounds, structures and processes. This is an area of largely untapped science, in part due to a scarcity of optimized facilities. Such measurements also entail unique experimental challenges. Lastly, this brief review describes the technique, its experimental challenges,more » recent progress in development of microbeam measurement capabilities, and several highlights illustrating applications in life sciences.« less

MIRIADS: miniature infrared imaging applications development system description and operation

NASA Astrophysics Data System (ADS)

Baxter, Christopher R.; Massie, Mark A.; McCarley, Paul L.; Couture, Michael E.

2001-10-01

A cooperative effort between the U.S. Air Force Research Laboratory, Nova Research, Inc., the Raytheon Infrared Operations (RIO) and Optics 1, Inc. has successfully produced a miniature infrared camera system that offers significant real-time signal and image processing capabilities by virtue of its modular design. This paper will present an operational overview of the system as well as results from initial testing of the 'Modular Infrared Imaging Applications Development System' (MIRIADS) configured as a missile early-warning detection system. The MIRIADS device can operate virtually any infrared focal plane array (FPA) that currently exists. Programmable on-board logic applies user-defined processing functions to the real-time digital image data for a variety of functions. Daughterboards may be plugged onto the system to expand the digital and analog processing capabilities of the system. A unique full hemispherical infrared fisheye optical system designed and produced by Optics 1, Inc. is utilized by the MIRIADS in a missile warning application to demonstrate the flexibility of the overall system to be applied to a variety of current and future AFRL missions.

Optical coherence tomography using the Niris system in otolaryngology

NASA Astrophysics Data System (ADS)

Rubinstein, Marc; Armstrong, William B.; Djalilian, Hamid R.; Crumley, Roger L.; Kim, Jason H.; Nguyen, Quoc A.; Foulad, Allen I.; Ghasri, Pedram E.; Wong, Brian J. F.

2009-02-01

Objectives: To determine the feasibility and accuracy of the Niris Optical Coherence Tomography (OCT) system in imaging of the mucosal abnormalities of the head and neck. The Niris system is the first commercially available OCT device for applications outside ophthalmology. Methods: We obtained OCT images of benign, premalignant and malignant lesions throughout the head and neck, using the Niris OCT imaging system (Imalux, Cleveland, OH). This imaging system has a tissue penetration depth of approximately 1-2mm, a scanning range of 2mm and a spatial depth resolution of approximately 10-20μm. Imaging was performed in the outpatient setting and in the operating room using a flexible probe. Results: High-resolution cross-sectional images from the oral cavity, nasal cavity, ears and larynx showed distinct layers and structures such as mucosa layer, basal membrane and lamina propria, were clearly identified. In the pathology images disruption of the basal membrane was clearly shown. Device set-up took approximately 5 minutes and the image acquisition was rapid. The system can be operated by the person performing the exam. Conclusions: The Niris system is non invasive and easy to incorporate into the operating room and the clinic. It requires minimal set-up and requires only one person to operate. The unique ability of the OCT offers high-resolution images showing the microanatomy of different sites. OCT imaging with the Niris device potentially offers an efficient, quick and reliable imaging modality in guiding surgical biopsies, intra-operative decision making, and therapeutic options for different otolaryngologic pathologies and premalignant disease.

Liver transplant center variability in accepting organ offers and its impact on patient survival

PubMed Central

Goldberg, David S.; French, Benjamin; Lewis, James D.; Scott, Frank I; Mamtani, Ronac; Gilroy, Richard; Halpern, Scott D.; Abt, Peter L

2015-01-01

Background & Aims Despite an allocation system designed to give deceased-donor livers to the sickest patients, many transplantable livers are declined by U.S. transplant centers. It is unknown whether centers vary in their propensities to decline organs for the highest-priority patients, and how these decisions directly impact patient outcomes. Methods We analyzed Organ Procurement and Transplantation Network (OPTN) data from 5/1/07-6/17/13, and included all adult liver-alone waitlist candidates offered an organ that was ultimately transplanted. We evaluated acceptance rates of liver offers for the highest-ranked patients and their subsequent waitlist mortality. Results Of the 23,740 unique organ offers, 8,882 (37.4%) were accepted for the first-ranked patient. Despite adjusting for organ quality and recipient severity of illness, transplant centers within and across geographic regions varied strikingly (p<0.001) in the percentage of organ offers they accepted for the highest-priority patients. Among all patients ranked first on waitlists, the adjusted center-specific organ acceptance rates ranged from 15.7% to 58.1%. In multivariable models, there was a 27% increased odds of waitlist mortality for every 5% absolute decrease in a center’s adjusted organ offer acceptance rate (adjusted OR: 1.27, 95% CI: 1.20–1.32). However, the absolute difference in median 5-year adjusted graft survival was 4% between livers accepted for the first-ranked patient, compared to those declined and transplanted at a lower position. Discussion There is marked variability in center practices regarding accepting livers allocated to the highest-priority patients. Center-level decisions to decline organs substantially increased patients’ odds of dying on the waitlist without a transplant. PMID:26626495

MyOcean Central Information System - Achievements and Perspectives

NASA Astrophysics Data System (ADS)

de Dianous, Rémi; Jolibois, Tony; Besnard, Sophie

2015-04-01

MyOcean (http://www.myocean.eu) is providing a pre-operational service, for forecasts, analysis and expertise on ocean currents, temperature, salinity, sea level, primary ecosystems and ice coverage. Since 2009, three successive projects (MyOcean-I, MyOcean-II and MyOcean-Follow-on) have been designed to prepare and to lead the demonstration phases of the future Copernicus Marine Environment Monitoring Service. The main goal of these projects was to build a system of systems offering the users a unique access point to European oceanographic data. Reaching this goal at European level with 59 partners from 28 different countries was a real challenge: initially, each local system had its own human processes and methodology, its own interfaces for production and dissemination. At the end of MyOcean Follow-on, any user can connect to one web portal, browse an interactive catalogue of products and services, use one login to access all data disseminated through harmonized interfaces in a common format and contact a unique centralized service desk. In this organization the central information system plays a key role. The production of observation and forecasting data is done by 48 Production Units (PU). Product download and visualisation are hosted by 26 Dissemination Units (DU). All these products and associated services are gathered in a single system hiding the intricate distributed organization of PUs and DUs. This central system will be presented in detail, including notably the technical choices in architecture and technologies which have been made and why, and the lessons learned during these years of real life of the system, taking into account internal and external feedbacks. Then, perspectives will be presented to sketch the future of such system in the next Marine Copernicus Service which is meant to be fully operational from 2015 onwards.

Reconnaissance Report on San Pedro Ports, California.

DTIC Science & Technology

1979-01-01

skirt completely around its periphery. More recent in technology than other types of vessels, ACV’s offer high speed at low drag. They offer a unique...concentrated on the present effect of the channel and on the communities through which it runs and on the citizens of those communities . The general...Vehicular traffic contributes significantly to the noise levels within the San Pedro Harbor area, and it is the dominating source within the area

Unmanned Aerial Vehicles unique cost estimating requirements

NASA Astrophysics Data System (ADS)

Malone, P.; Apgar, H.; Stukes, S.; Sterk, S.

Unmanned Aerial Vehicles (UAVs), also referred to as drones, are aerial platforms that fly without a human pilot onboard. UAVs are controlled autonomously by a computer in the vehicle or under the remote control of a pilot stationed at a fixed ground location. There are a wide variety of drone shapes, sizes, configurations, complexities, and characteristics. Use of these devices by the Department of Defense (DoD), NASA, civil and commercial organizations continues to grow. UAVs are commonly used for intelligence, surveillance, reconnaissance (ISR). They are also use for combat operations, and civil applications, such as firefighting, non-military security work, surveillance of infrastructure (e.g. pipelines, power lines and country borders). UAVs are often preferred for missions that require sustained persistence (over 4 hours in duration), or are “ too dangerous, dull or dirty” for manned aircraft. Moreover, they can offer significant acquisition and operations cost savings over traditional manned aircraft. Because of these unique characteristics and missions, UAV estimates require some unique estimating methods. This paper describes a framework for estimating UAV systems total ownership cost including hardware components, software design, and operations. The challenge of collecting data, testing the sensitivities of cost drivers, and creating cost estimating relationships (CERs) for each key work breakdown structure (WBS) element is discussed. The autonomous operation of UAVs is especially challenging from a software perspective.

Optimising the benefits of community health workers' unique position between communities and the health sector: A comparative analysis of factors shaping relationships in four countries.

PubMed

Kok, Maryse C; Ormel, Hermen; Broerse, Jacqueline E W; Kane, Sumit; Namakhoma, Ireen; Otiso, Lilian; Sidat, Moshin; Kea, Aschenaki Z; Taegtmeyer, Miriam; Theobald, Sally; Dieleman, Marjolein

2017-11-01

Community health workers (CHWs) have a unique position between communities and the health sector. The strength of CHWs' relationships with both sides influences their motivation and performance. This qualitative comparative study aimed at understanding similarities and differences in how relationships between CHWs, communities and the health sector were shaped in different Sub-Saharan African settings. The study demonstrates a complex interplay of influences on trust and CHWs' relationships with their communities and actors in the health sector. Mechanisms influencing relationships were feelings of (dis)connectedness, (un)familiarity and serving the same goals, and perceptions of received support, respect, competence, honesty, fairness and recognition. Sometimes, constrained relationships between CHWs and the health sector resulted in weaker relationships between CHWs and communities. The broader context (such as the socio-economic situation) and programme context (related to, for example, task-shifting, volunteering and supervision) in which these mechanisms took place were identified. Policy-makers and programme managers should take into account the broader context and could adjust CHW programmes so that they trigger mechanisms that generate trusting relationships between CHWs, communities and other actors in the health system. This can contribute to enabling CHWs to perform well and responding to the opportunities offered by their unique intermediary position.

The dynamics of health care reform--learning from a complex adaptive systems theoretical perspective.

PubMed

Sturmberg, Joachim P; Martin, Carmel M

2010-10-01

Health services demonstrate key features of complex adaptive systems (CAS), they are dynamic and unfold in unpredictable ways, and unfolding events are often unique. To better understand the complex adaptive nature of health systems around a core attractor we propose the metaphor of the health care vortex. We also suggest that in an ideal health care system the core attractor would be personal health attainment. Health care reforms around the world offer an opportunity to analyse health system change from a complex adaptive perspective. At large health care reforms have been pursued disregarding the complex adaptive nature of the health system. The paper details some recent reforms and outlines how to understand their strategies and outcomes, and what could be learnt for future efforts, utilising CAS principles. Current health systems show the inherent properties of a CAS driven by a core attractor of disease and cost containment. We content that more meaningful health systems reform requires the delicate task of shifting the core attractor from disease and cost containment towards health attainment.

An integrated cell-free metabolic platform for protein production and synthetic biology

PubMed Central

Jewett, Michael C; Calhoun, Kara A; Voloshin, Alexei; Wuu, Jessica J; Swartz, James R

2008-01-01

Cell-free systems offer a unique platform for expanding the capabilities of natural biological systems for useful purposes, i.e. synthetic biology. They reduce complexity, remove structural barriers, and do not require the maintenance of cell viability. Cell-free systems, however, have been limited by their inability to co-activate multiple biochemical networks in a single integrated platform. Here, we report the assessment of biochemical reactions in an Escherichia coli cell-free platform designed to activate natural metabolism, the Cytomim system. We reveal that central catabolism, oxidative phosphorylation, and protein synthesis can be co-activated in a single reaction system. Never before have these complex systems been shown to be simultaneously activated without living cells. The Cytomim system therefore promises to provide the metabolic foundation for diverse ab initio cell-free synthetic biology projects. In addition, we describe an improved Cytomim system with enhanced protein synthesis yields (up to 1200 mg/l in 2 h) and lower costs to facilitate production of protein therapeutics and biochemicals that are difficult to make in vivo because of their toxicity, complexity, or unusual cofactor requirements. PMID:18854819

REU Programs at Field Research Stations Offer Unique Advantages that may Enhance Retention of Students in STEM Fields.

NASA Astrophysics Data System (ADS)

Kim, D. Y.; Marinelli, R. L.; Heidelberg, K., IV

2014-12-01

Studies have shown that undergraduate participation in research opportunities strengthens the retention of students in STEM fields. Increasing students' confidence levels in their scientific abilities, aiding in the development of their scientific identity, and strengthening their sense of belonging to a scientific community have been cited as important contributing factors. Research field stations offer unique advantages that amplify these benefits by challenging students to plan and work in the field, enhancing networking opportunities with multi-disciplinary professionals from numerous institutions and hierarchical levels, and creating a stronger sense of belonging and comradery within a science community. The USC Wrigley Institute for Environmental Studies' (WIES) Research Experiences for Undergraduates (REU) program is an 8-week program that begins on the main USC campus in Los Angeles and moves to a marine field station on Catalina Island during weeks 2-7, before returning to the mainland to complete the last week of the program. This unique model provides REU students with an opportunity to become integrated into faculty mentors' labs on the main campus, while exposing them to life as a researcher at a field station, both of which contribute significantly to the students' development as a scientist. Here, we present the WIES REU model and include a discussion of benefits and challenges to this unique infrastructure.

Working Towards Führer: A Chaotic View

NASA Astrophysics Data System (ADS)

Cakar, Ulas

Leadership is a concept that has been discussed since the beginning of history. Even though there have been many theories in the field accepting leadership's role in bringing order, chaotic aspects of leadership are generally neglected. This chapter aims to examine the leadership beyond an orderly interpretation of universe. For this purpose, Third Reich period and leadership during this period will be examined. Ian Kershaw's "Working Towards Führer" concept provides a unique understanding of leadership concept. It goes beyond the dualist depiction of Third Reich, it does not state Adolf Hitler as an all powerful dictator, or a weak one. Rather, he expresses that due to the conditions in the Third Reich, Adolf Hitler was both of this. This complex situation can be understood deeper when it is examined through the lens of chaos theory. This study contributes to the field by being the first in using chaos theory for examining "Working Towards Führer" concept and its development. Seemingly orderly nature of synchronization process and its vortex will be shown. Adolf Hitler's storm spot position in the chaotic system and its dynamics are explained. War's entropic power and its effect on the downfall of the system is crucial in understanding this unique chaotic system. The chaotic pattern of "Working Towards Führer" offers an opportunity to analyze the complexities of the leadership concept.

Ultrasonic material property determinations

NASA Technical Reports Server (NTRS)

Serabian, S.

1986-01-01

The use and potential offered by ultrasonic velocity and attenuation measurements to determine and/or monitor material properties is explored. The basis for such unique measurements along with examples of materials from a variety of industries are presented.

Hypertension Detection and Results Among Young Adults

ERIC Educational Resources Information Center

Garner, Walton R.; Gerald, Michael C.

1977-01-01

A comprehensive hypertension education and detection program, in which 2,852 students were tested and, if necessary, referred to area physicians, illustrates the unique position a university setting offers for work in this area. (MB)

NASA's Space Launch System: An Evolving Capability for Exploration An Evolving Capability for Exploration

NASA Technical Reports Server (NTRS)

Creech, Stephen D.; Crumbly, Christopher M.; Robinson, Kimerly F.

2016-01-01

A foundational capability for international human deep-space exploration, NASA's Space Launch System (SLS) vehicle represents a new spaceflight infrastructure asset, creating opportunities for mission profiles and space systems that cannot currently be executed. While the primary purpose of SLS, which is making rapid progress towards initial launch readiness in two years, will be to support NASA's Journey to Mars, discussions are already well underway regarding other potential utilization of the vehicle's unique capabilities. In its initial Block 1 configuration, capable of launching 70 metric tons (t) to low Earth orbit (LEO), SLS is capable of propelling the Orion crew vehicle to cislunar space, while also delivering small CubeSat-class spacecraft to deep-space destinations. With the addition of a more powerful upper stage, the Block 1B configuration of SLS will be able to deliver 105 t to LEO and enable more ambitious human missions into the proving ground of space. This configuration offers opportunities for launching co-manifested payloads with the Orion crew vehicle, and a class of secondary payloads, larger than today's CubeSats. Further upgrades to the vehicle, including advanced boosters, will evolve its performance to 130 t in its Block 2 configuration. Both Block 1B and Block 2 also offer the capability to carry 8.4- or 10-m payload fairings, larger than any contemporary launch vehicle. With unmatched mass-lift capability, payload volume, and C3, SLS not only enables spacecraft or mission designs currently impossible with contemporary EELVs, it also offers enhancing benefits, such as reduced risk, operational costs and/or complexity, shorter transit time to destination or launching large systems either monolithically or in fewer components. This paper will discuss both the performance and capabilities of Space Launch System as it evolves, and the current state of SLS utilization planning.

A tale of two neglected systems-structure and function of the thin- and thick-walled sieve tubes in monocotyledonous leaves.

PubMed

Botha, C E J

2013-01-01

There is a large body of information relating to the ontogeny, development and the vasculature of eudicotyledonous leaves. However, there is less information available concerning the vascular anatomy of monocotyledonous leaves. This is surprising, given that there are two uniquely different phloem systems present in large groups such as grasses and sedges. Monocotyledonous leaves contain marginal, large, intermediate, and small longitudinal veins that are interconnected by numerous transverse veins. The longitudinal veins contain two metaphloem sieve tube types, which, based upon their ontogeny and position within the phloem, are termed early (thin-walled) and late (thick-walled) sieve tubes. Early metaphloem comprises sieve tubes, companion cells and vascular parenchyma (VP) cells, whilst the late metaphloem, contains thick-walled sieve tubes (TSTs) that lack companion cells. TSTs are generally adjacent to, or no more than one cell removed from the metaxylem. Unlike thin-walled sieve tube (ST) -companion cell complexes, TSTs are connected to parenchyma by pore-plasmodesma units and are generally symplasmically isolated from the STs. This paper addresses key structural and functional differences between thin- and thick-walled sieve tubes and explores the unique advantages of alternate transport strategies that this 5-7 million years old dual system may offer. It would seem that these two systems may enhance, add to, or play a significant role in increasing the efficiency of solute retrieval as well as of assimilate transfer.

Polymeric microchip for the simultaneous determination of anions and cations by hydrodynamic injection using a dual-channel sequential injection microchip electrophoresis system.

PubMed

Gaudry, Adam J; Nai, Yi Heng; Guijt, Rosanne M; Breadmore, Michael C

2014-04-01

A dual-channel sequential injection microchip capillary electrophoresis system with pressure-driven injection is demonstrated for simultaneous separations of anions and cations from a single sample. The poly(methyl methacrylate) (PMMA) microchips feature integral in-plane contactless conductivity detection electrodes. A novel, hydrodynamic "split-injection" method utilizes background electrolyte (BGE) sheathing to gate the sample flows, while control over the injection volume is achieved by balancing hydrodynamic resistances using external hydrodynamic resistors. Injection is realized by a unique flow-through interface, allowing for automated, continuous sampling for sequential injection analysis by microchip electrophoresis. The developed system was very robust, with individual microchips used for up to 2000 analyses with lifetimes limited by irreversible blockages of the microchannels. The unique dual-channel geometry was demonstrated by the simultaneous separation of three cations and three anions in individual microchannels in under 40 s with limits of detection (LODs) ranging from 1.5 to 24 μM. From a series of 100 sequential injections the %RSDs were determined for every fifth run, resulting in %RSDs for migration times that ranged from 0.3 to 0.7 (n = 20) and 2.3 to 4.5 for peak area (n = 20). This system offers low LODs and a high degree of reproducibility and robustness while the hydrodynamic injection eliminates electrokinetic bias during injection, making it attractive for a wide range of rapid, sensitive, and quantitative online analytical applications.

Synchronization in spread spectrum laser radar systems based on PMD-DLL

NASA Astrophysics Data System (ADS)

Buxbaum, Bernd; Schwarte, Rudolf; Ringbeck, Thorsten; Luan, Xuming; Zhang, Zhigang; Xu, Zhanping; Hess, H.

2000-09-01

This paper proposes a new optoelectronic delay locked loop (OE-DLL) and its use in optical ranging systems. The so called PMD-DLL receiver module is based on a novel electro-optical modulator (EOM), called the Photonic Mixer Device (PMD). This sensor element is a semiconductor device, which combines fast optical sensing and mixing of incoherent light signals in one component part by its unique and powerful principle of operation. Integration of some simple additional on-chip components offers a high integrated electro-optical correlation unit. Simulations and experimental results have already impressively verified the operation principle of PMD structures, all realized in CMOS technology so far. Although other technologies are also promising candidates for the PMD realization they should not be further discussed in this contribution. The principle of the new DLL approach is intensively discussed in this paper. Theoretical analysis as well as experimental results of a realized PMD-DLL system are demonstrated and judged. Due to the operation principle of sophisticated PMD devices and their unique features, a correlation process may be realized in order to synchronize a reflected incoherent light wave with an electronic reference signal. The phase shift between both signals represents the distance to an obstacle and may be determined by means of the synchronization process. This new approach, avoiding so far needed critical components such as broadband amplifiers and mixers for the detection of small photo currents in optical distance measurement, offers an extremely fast and precise phase determination in ranging applications based on the time- of-flight (TOF) principle. However, the optical measurement signal may be incoherent -- therefore a laser source is not needed imperatively. The kind of waveform used for the modulation of the light signal is variable and depends on the demands of every specific application. Even if there are plenty other alternatives (e.g., heterodyne techniques), in this contribution only so called quasi-heterodyne techniques - - also known as phase shifting methods -- are discussed and used for the implementation. The light modulation schemes described in this contribution are square-wave as well as pseudo-noise modulation. The latter approach, inspired by the wide spread use in communication as well as in position detection (e.g., IS-95 and GPS), offers essential advantages and is the most promising modulation method for the ranging approach. So called CDMA (code division multiple access) systems form a major task in communication technology investigations since the third generation mobile phone standard is also partly based on this principle. Fast and reliable synchronization in direct sequence spread spectrum communication systems (DSSS) differs hardly from the already mentioned ranging approach and will also be discussed. The possibility to integrate all components in a monolithic PMD based DLL design is also presented and discussed. This method might offer the feature to integrate complete lines or matrixes of PMD based DLLs for highly parallel, multidimensional ranging. Finally, an outlook is given with regard to further optimized PMD front ends. An estimation of the expected characteristics concerning accuracy and speed of the distance measurement is given in conclusion.

On the Potential of a New Generation of Magnetometers for MEG: A Beamformer Simulation Study

PubMed Central

Boto, Elena; Bowtell, Richard; Krüger, Peter; Fromhold, T. Mark; Morris, Peter G.; Meyer, Sofie S.; Barnes, Gareth R.; Brookes, Matthew J.

2016-01-01

Magnetoencephalography (MEG) is a sophisticated tool which yields rich information on the spatial, spectral and temporal signatures of human brain function. Despite unique potential, MEG is limited by a low signal-to-noise ratio (SNR) which is caused by both the inherently small magnetic fields generated by the brain, and the scalp-to-sensor distance. The latter is limited in current systems due to a requirement for pickup coils to be cryogenically cooled. Recent work suggests that optically-pumped magnetometers (OPMs) might be a viable alternative to superconducting detectors for MEG measurement. They have the advantage that sensors can be brought to within ~4 mm of the scalp, thus offering increased sensitivity. Here, using simulations, we quantify the advantages of hypothetical OPM systems in terms of sensitivity, reconstruction accuracy and spatial resolution. Our results show that a multi-channel whole-head OPM system offers (on average) a fivefold improvement in sensitivity for an adult brain, as well as clear improvements in reconstruction accuracy and spatial resolution. However, we also show that such improvements depend critically on accurate forward models; indeed, the reconstruction accuracy of our simulated OPM system only outperformed that of a simulated superconducting system in cases where forward field error was less than 5%. Overall, our results imply that the realisation of a viable whole-head multi-channel OPM system could generate a step change in the utility of MEG as a means to assess brain electrophysiological activity in health and disease. However in practice, this will require both improved hardware and modelling algorithms. PMID:27564416

Histone modifications controlling native and induced neural stem cell identity.

PubMed

Broccoli, Vania; Colasante, Gaia; Sessa, Alessandro; Rubio, Alicia

2015-10-01

During development, neural progenitor cells (NPCs) that are capable of self-renewing maintain a proliferative cellular pool while generating all differentiated neural cell components. Although the genetic network of transcription factors (TFs) required for neural specification has been well characterized, the unique set of histone modifications that accompanies this process has only recently started to be investigated. In vitro neural differentiation of pluripotent stem cells is emerging as a powerful system to examine epigenetic programs. Deciphering the histone code and how it shapes the chromatin environment will reveal the intimate link between epigenetic changes and mechanisms for neural fate determination in the developing nervous system. Furthermore, it will offer a molecular framework for a stringent comparison between native and induced neural stem cells (iNSCs) generated by direct neural cell conversion. Copyright © 2015 Elsevier Ltd. All rights reserved.

Comparison of Optimal Small Spacecraft Micro Electric Propulsion Technologies for Mission Opportunities

NASA Technical Reports Server (NTRS)

Spangelo, Sara

2015-01-01

The goal of this paper is to explore the mission opportunities that are uniquely enabled by U-class Solar Electric Propulsion (SEP) technologies. Small SEP thrusters offers significant advantages relative to existing technologies and will revolutionize the class of mission architectures that small spacecraft can accomplish by enabling trajectory maneuvers with significant change in velocity requirements and reaction wheel-free attitude control. This paper aims to develop and apply a common system-level modeling framework to evaluate these thrusters for relevant upcoming mission scenarios, taking into account the mass, power, volume, and operational constraints of small highly-constrained missions. We will identify the optimal technology for broad classes of mission applications for different U-class spacecraft sizes and provide insights into what constrains the system performance to identify technology areas where improvements are needed.

Nature-Inspired Design of Artificial Solar-to-Fuel Conversion Systems based on Copper Phosphate Microflowers.

PubMed

Wang, Jing; Zhu, Ting; Ho, Ghim Wei

2016-07-07

Phosphates play significant roles in plant photosynthesis by mediating electron transportation and furnishing energy for CO2 reduction. Motivated by this, we demonstrate herein an artificial solar-to-fuel conversion system, involving versatile copper phosphate microflowers as template and titanium dioxide nanoparticles as host photocatalyst. The elaborate flowerlike architectures, coupled with a unique proton-reduction cycle from interchangeability of different species of orthophosphate ions, not only offer a 2D nanosheet platform for an optimal heterostructure interface but also effectively augment charge-carrier transfer, thereby contributing to enhanced photoactivity and hydrogen generation. These nature-inspired, phosphate-derived nanocomposites advance the synthesis of a large variety of functional materials, which holds great potential for photochemical, photoelectric and catalytic applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Effect of gravity on vestibular neural development

NASA Technical Reports Server (NTRS)

Ross, M. D.; Tomko, D. L.

1998-01-01

The timing, molecular basis, and morphophysiological and behavioral consequences of the interaction between external environment and the internal genetic pool that shapes the nervous system over a lifetime remain important questions in basic neuroscientific research. Space station offers the opportunity to study this interaction over several life cycles in a variety of organisms. This short review considers past work in altered gravity, particularly on the vestibular system, as the basis for proposing future research on space station, and discusses the equipment necessary to achieve goals. It is stressed that, in keeping with the international investment being made in this research endeavor, both the questions asked and the technologies to be developed should be bold. Advantage must be taken of this unique research environment to expand the frontiers of neuroscience. Copyright 1998 Published by Elsevier Science B.V.

Decade of the Brain 1990--2000: Maximizing human potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-04-01

The US Decade of the Brain offers scientists throughout the Federal Government a unique opportunity to advance and apply scientific knowledge about the brain and nervous system. During the next 10 years, scientists hope to maximize human potential through studies of human behavior, senses and communication, learning and memory, genetic/chemical alterations, and environmental interactions. Progress in these areas should lead to reductions in mortality from brain and nervous system disorders and to improvements in the quality of life. This report identifies nine research areas that could form the basis of an integrated program in the brain and behavioral sciences. Amore » chart summarizing the Federal activities in these nine areas may be found at the back of the report. In addition, three areas that span the nine research areas -- basic research, technology and international activities -- are considered.« less

Capillarity ion concentration polarization as spontaneous desalting mechanism.

PubMed

Park, Sungmin; Jung, Yeonsu; Son, Seok Young; Cho, Inhee; Cho, Youngrok; Lee, Hyomin; Kim, Ho-Young; Kim, Sung Jae

2016-04-01

To overcome a world-wide water shortage problem, numerous desalination methods have been developed with state-of-the-art power efficiency. Here we propose a spontaneous desalting mechanism referred to as the capillarity ion concentration polarization. An ion-depletion zone is spontaneously formed near a nanoporous material by the permselective ion transportation driven by the capillarity of the material, in contrast to electrokinetic ion concentration polarization which achieves the same ion-depletion zone by an external d.c. bias. This capillarity ion concentration polarization device is shown to be capable of desalting an ambient electrolyte more than 90% without any external electrical power sources. Theoretical analysis for both static and transient conditions are conducted to characterize this phenomenon. These results indicate that the capillarity ion concentration polarization system can offer unique and economical approaches for a power-free water purification system.

Quantum droplet of one-dimensional bosons with a three-body attraction

NASA Astrophysics Data System (ADS)

Sekino, Yuta; Nishida, Yusuke

2018-01-01

Ultracold atoms offer valuable opportunities where interparticle interactions can be controlled at will. In particular, by extinguishing the two-body interaction, one can realize unique systems governed by the three-body interaction, which is otherwise hidden behind the two-body interaction. Here we study one-dimensional bosons with a weak three-body attraction and show that they form few-body bound states as well as a many-body droplet stabilized by the quantum mechanical effect. Their binding energies relative to that of three bosons are all universal and the ground-state energy of the dilute droplet is found to grow exponentially as EN/E3→exp(8 N2/√{3 }π ) with increasing particle number N ≫1 . The realization of our system with coupled two-component bosons in an optical lattice is also discussed.

Under-sampling in a Multiple-Channel Laser Vibrometry System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corey, Jordan

2007-03-01

Laser vibrometry is a technique used to detect vibrations on objects using the interference of coherent light with itself. Most vibrometry systems process only one target location at a time, but processing multiple locations simultaneously provides improved detection capabilities. Traditional laser vibrometry systems employ oversampling to sample the incoming modulated-light signal, however as the number of channels increases in these systems, certain issues arise such a higher computational cost, excessive heat, increased power requirements, and increased component cost. This thesis describes a novel approach to laser vibrometry that utilizes undersampling to control the undesirable issues associated with over-sampled systems. Undersamplingmore » allows for significantly less samples to represent the modulated-light signals, which offers several advantages in the overall system design. These advantages include an improvement in thermal efficiency, lower processing requirements, and a higher immunity to the relative intensity noise inherent in laser vibrometry applications. A unique feature of this implementation is the use of a parallel architecture to increase the overall system throughput. This parallelism is realized using a hierarchical multi-channel architecture based on off-the-shelf programmable logic devices (PLDs).« less

Pulsed Plasma Thrusters for Small Spacecraft Attitude Control

NASA Technical Reports Server (NTRS)

McGuire, Melissa L.; Myers, Roger M.

1996-01-01

Pulsed plasma thrusters (PPT's) are a new option for attitude control of a small spacecraft and may result in reduced attitude control system (ACS) mass and cost. The primary purpose of an ACS is to orient the spacecraft configuration to the desired accuracy in inertial space. The ACS functions for which the PPT system will be analyzed include disturbance torque compensation and slewing maneuvers such as sun acquisition for which the small impulse bit and high specific impulse of the PPT offers unique advantages. The NASA Lewis Reserach Center (LeRC) currently has a contracted flight PPT system development program in place with Olin Aerospace and a delivery date of October 1997. The PPT system in this study are based upon the work being done under the NASA LeRC program. Analysis of the use of PPT's for ACS showed that the replacement of the standard momentum wheels and torque rods systems with a PTT system to perform the altitude control maneuvers on a small low Earth orbiting spacecraft reduced the ACS mass by 50 to 75 percent with no increase in required power level over comparable wheel-based systems.

Instrumentation concepts and requirements for a space vacuum research facility. [molecular shield for spaceborne experiments

NASA Technical Reports Server (NTRS)

Norton, H. N.

1979-01-01

An earth-orbiting molecular shield that offers a unique opportunity for conducting physics, chemistry, and material processing experiments under a combination of environmental conditions that are not available in terrestrial laboratories is equipped with apparatus for forming a molecular beam from the freestream. Experiments are carried out using a moderate energy, high flux density, high purity atomic oxygen beam in the very low density environment within the molecular shield. As a minimum, the following instruments are required for the molecular shield: (1) a mass spectrometer; (2) a multifunction material analysis instrumentation system; and (3) optical spectrometry equipment. The design is given of a furlable molecular shield that allows deployment and retrieval of the system (including instrumentation and experiments) to be performed without contamination. Interfaces between the molecular shield system and the associated spacecraft are given. An in-flight deployment sequence is discussed that minimizes the spacecraft-induced contamination in the vicinity of the shield. Design approaches toward a precursor molecular shield system are shown.

A framework for nowcasting and forecasting of rainfall-triggered landslide activity using remotely sensed data

NASA Astrophysics Data System (ADS)

Kirschbaum, Dalia; Stanley, Thomas

2016-04-01

Remote sensing data offers the unique perspective to provide situational awareness of hydrometeorological hazards over large areas in a way that is impossible to achieve with in situ data. Recent work has shown that rainfall-triggered landslides, while typically local hazards that occupy small spatial areas, can be approximated over regional or global scales in near real-time. This work presents a regional and global approach to approximating potential landslide activity using the landslide hazard assessment for situational awareness (LHASA) model. This system couples remote sensing data, including Global Precipitation Measurement rainfall data, Shuttle Radar Topography Mission and other surface variables to estimate where and when landslide activity may be likely. This system also evaluates the effectiveness of quantitative precipitation estimates from the Goddard Earth Observing System Model, Version 5 to provide a 24 forecast of potential landslide activity. Preliminary results of the LHASA model and implications for are presented for a regional version of this system in Central America as well as a prototype global approach.

Dynamical Mass Segregation Versus Disruption of Binary Stars in Dense Stellar Systems

NASA Astrophysics Data System (ADS)

de Grijs, Richard; Li, C.; Deng, L.

2013-01-01

Upon their formation, dynamically cool (collapsing) star clusters will, within only a few million years, achieve stellar mass segregation for stars down to a few solar masses due to gravitational two-body encounters. Since binary systems are, on average, more massive than single stars, one would expect them to also rapidly mass segregate dynamically. Contrary to these expectations and based on high-resolution Hubble Space Telescope observations, we show that the compact, 15-30 Myr-old Large Magellanic Cloud cluster NGC 1818 is characterized by an increasing fraction of F-star binary systems (with combined masses of 1.3-1.6 solar masses) with increasing distance from the cluster center. This offers unprecedented support of the theoretically predicted but thus far unobserved dynamical disruption processes of the significant population of "soft" binary systems (with relatively low binding energies compared to the kinetic energy of their stellar members) in star clusters, which we could unravel by virtue of the cluster's unique combination of youth and high stellar density.

Thermodynamic analysis of Direct Urea Solid Oxide Fuel Cell in combined heat and power applications

NASA Astrophysics Data System (ADS)

Abraham, F.; Dincer, I.

2015-12-01

This paper presents a comprehensive steady state modelling and thermodynamic analysis of Direct Urea Solid Oxide Fuel Cell integrated with Gas Turbine power cycle (DU-SOFC/GT). The use of urea as direct fuel mitigates public health and safety risks associated with the use of hydrogen and ammonia. The integration scheme in this study covers both oxygen ion-conducting solid oxide fuel cells (SOFC-O) and hydrogen proton-conducting solid oxide fuel cells (SOFC-H). Parametric case studies are carried out to investigate the effects of design and operating parameters on the overall performance of the system. The results reveal that the fuel cell exhibited the highest level of exergy destruction among other system components. Furthermore, the SOFC-O based system offers better overall performance than that with the SOFC-H option mainly due to the detrimental reverse water-gas shift reaction at the SOFC anode as well as the unique configuration of the system.

Virtual Reality to Train Diagnostic Skills in Eating Disorders. Comparison of two Low Cost Systems.

PubMed

Gutiérrez-Maldonado, José; Ferrer-García, Marta; Plasanjuanelo, Joana; Andrés-Pueyo, Antonio; Talarn-Caparrós, Antoni

2015-01-01

Enhancing the ability to perform differential diagnosis and psychopathological exploration is important for students who wish to work in the clinical field, as well as for professionals already working in this area. Virtual reality (VR) simulations can immerse students totally in educational experiences in a way that is not possible using other methods. Learning in a VR environment can also be more effective and motivating than usual classroom practices. Traditionally, immersion has been considered central to the quality of a VR system; immersive VR is considered a special and unique experience that cannot achieved by three-dimensional (3D) interactions on desktop PCs. However, some authors have suggested that if the content design is emotionally engaging, immersive systems are not always necessary. The main purpose of this study is to compare the efficacy and usability of two low-cost VR systems, offering different levels of immersion, in order to develop the ability to perform diagnostic interviews in eating disorders by means of simulations of psychopathological explorations.

Patterns of Responding in the Word Associations of West African Children

ERIC Educational Resources Information Center

Sharp, Donald; Cole, Michael

1972-01-01

Studies conducted among the Kpelle of north central Liberia whose present cultural milieu offers unique possibilities for studying the role of particular experiential factors, particularly education, on the development of paradigmatic response. (Authors)

Recent advances in applied nanoscience for food safety

USDA-ARS?s Scientific Manuscript database

Ongoing developments in nanotechnology offer potential to transform agriculture in several areas, including food safety, quality, packaging, product traceability, food processing, and bioactive delivery. These nanoscience-based applications utilize the unique properties of materials with a dimension...

REGIONAL CARDIAC BLOOD FLOW WITH AIR PARTICLE EXPOSURE

EPA Science Inventory

This proposal offers the unique application of novel techniques to improve understanding of the mechanisms whereby ambient particulate exerts deleterious influences on the heart and circulation. Enhanced ischemia has broad implications for cardiac morbidity and mor...

76 FR 69311 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-08

...'') and broker-dealers increased authority and flexibility to offer new and unique market data to..., providing virtually limitless opportunities for entrepreneurs who wish to produce and distribute their own...

Developing a remote practice office.

PubMed

D'Elia, V L

1987-11-01

Remote practice offices (RPOs) offer unique opportunities for hospitals and physicians to increase market share from targeted areas where previously only limited demand existed. This article discusses the benefits and explores the fundamentals of developing a remote practice office.

How to Apply for a P3 Grant

EPA Pesticide Factsheets

EPA's P3 – People, Prosperity, and the Planet—Program is a unique college competition for designing solutions for a sustainable future. P3 offers students quality hands-on experience that brings their classroom learning to life

The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders.

PubMed

Berk, Thomas; Silberstein, Stephen D

2018-03-14

Lidocaine, an amide anesthetic, has been used in the treatment of a wide variety of pain disorders for over 75 years. In addition to pain control, lidocaine is an anti-arrhythmic agent and has anti-inflammatory properties. Lidocaine's unique properties, including nonlinear pharmacokinetics, have limited its modern-day use. The purpose of this review is to offer a better understanding of the properties of this unique treatment, which we hope will allow more practitioners to offer this to their patients. An analysis of the history, pharmacokinetics, and relevant uses of lidocaine in headache medicine based on a synthesis of the medical literature and clinical experience. Lidocaine is an amide anesthetic that inhibits voltage gated sodium channels, and lidocaine metabolism occurs exclusively in the liver. One lidocaine metabolite has its own unique properties and may be an active form of the drug. Open label and retrospective studies have investigated the use of lidocaine in many headache disorders, primarily via injection or infusion. Further research into the active metabolite of lidocaine may allow for its use as a novel nonopiate treatment of chronic pain. © 2018 American Headache Society.

Transition Services for DHH Adolescents and Young Adults With Disabilities: Challenges and Theoretical Frameworks.

PubMed

Luft, Pamela

2015-01-01

Deaf and hard of hearing (DHH) adolescents and young adults with disabilities (DWD) are a highly diverse group who may also demonstrate a range of functional limitations. These present unique challenges to professional efforts to provide high-quality transition services. Despite these issues, a majority of this population has cognitive abilities within the typical range, and therefore, their transition expectations should be commensurately high in comparison to those of their DHH peers. Research-based transition practices offer a range of interventions, and although none have been validated with DHH or DWD students, several provide important foundational learning opportunities. Yet their implementation will require modifications with programming and expertise beyond what is available in most school districts. Use of a multilevel, ecological framework and person-centered planning offers systematic strategies for increasing access to transition resources and supports to address these unique needs and lead to successful adulthood.

Cubesats: Cost-effective science and technology platforms for emerging and developing nations

NASA Astrophysics Data System (ADS)

Woellert, Kirk; Ehrenfreund, Pascale; Ricco, Antonio J.; Hertzfeld, Henry

2011-02-01

The development, operation, and analysis of data from cubesats can promote science education and spur technology utilization in emerging and developing nations. This platform offers uniquely low construction and launch costs together with a comparative ubiquity of launch providers; factors that have led more than 80 universities and several emerging nations to develop programs in this field. Their small size and weight enables cubesats to “piggyback” on rocket launches and accompany orbiters travelling to Moon and Mars. It is envisaged that constellations of cubesats will be used for larger science missions. We present a brief history, technology overview, and summary of applications in science and industry for these small satellites. Cubesat technical success stories are offered along with a summary of pitfalls and challenges encountered in both developed and emerging nations. A discussion of economic and public policy issues aims to facilitate the decision-making process for those considering utilization of this unique technology.

Listing a Geological Rarity of ‘Stone Balls’ in Kysuce Among World Geotourism Destinations

NASA Astrophysics Data System (ADS)

Duraj, Miloš; Niemiec, Dominik; Marschalko, Marian; Yilmaz, Işik

2016-10-01

Kysuce, situated on the border with the Czech Republic and Poland, belongs among distinctive regions in the Slovak Republic. This region offers tourism many interesting sites. Few decades ago, Kysuce offered tourists and visitors well-preserved national architecture, which is nowadays concentrated in an open-air museum Vychylovka. Thanks to the rich afforestation and a sophisticated network of signs for hikers, hiking has been very popular. The ground relief and climatic conditions also encourage winter sports. The world-wide development of geotourism has also concerned this region. Despite a low-varied geological structure, there are unique geological formations that have attracted attention for years. For example, tourists visit the interesting mineralized springs and a remarkable crude oil seep in Korna. Geologically unique are also the occurrences of ‘stone balls’ from sandstone and conglomerates. This phenomenon has attracted attention of both geologists and esotericism supporters.

Power in the hypnotic relationship: therapeutic or abusive?

PubMed

Walling, D P; Levine, R E

1997-01-01

The unique relationship between hypnotist and subject has been theorized as one explanation for the effectiveness of hypnosis. This relationship carries a power differential, present in most therapeutic relationships, but accentuated by hypnosis. The power differential is sometimes perceived as the ability of the hypnotist to control the subject. Perceptions of hypnosis offered by stage hypnotists, the popular media, and some clinicians perpetuate the notion that the hypnotist has the ability to exert undue influence upon the client. The present article examines the relationship between hypnotist and subject focusing on issues of power and control. The authors examine the unique dynamics accompanying the use of hypnosis and their impact on the therapeutic dyad. Evidence is offered demonstrating the power differential, and how this differential can serve as either a positive or negative agent of change. Therapists should be aware of the dynamics created by using hypnosis. Implications for training therapists in the use of hypnosis are suggested.

A love affair with Bacillus subtilis.

PubMed

Losick, Richard

2015-01-30

My career in science was launched when I was an undergraduate at Princeton University and reinforced by graduate training at the Massachusetts Institute of Technology. However, it was only after I moved to Harvard University as a junior fellow that my affections were captured by a seemingly mundane soil bacterium. What Bacillus subtilis offered was endless fascinating biological problems (alternative sigma factors, sporulation, swarming, biofilm formation, stochastic cell fate switching) embedded in a uniquely powerful genetic system. Along the way, my career in science became inseparably interwoven with teaching and mentoring, which proved to be as rewarding as the thrill of discovery. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Power Hardware-in-the-Loop (PHIL) Testing Facility for Distributed Energy Storage (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neubauer.J.; Lundstrom, B.; Simpson, M.

2014-06-01

The growing deployment of distributed, variable generation and evolving end-user load profiles presents a unique set of challenges to grid operators responsible for providing reliable and high quality electrical service. Mass deployment of distributed energy storage systems (DESS) has the potential to solve many of the associated integration issues while offering reliability and energy security benefits other solutions cannot. However, tools to develop, optimize, and validate DESS control strategies and hardware are in short supply. To fill this gap, NREL has constructed a power hardware-in-the-loop (PHIL) test facility that connects DESS, grid simulator, and load bank hardware to a distributionmore » feeder simulation.« less

Making the invisible visible.

PubMed

van Steensel, Maurice A M

2016-04-01

In this review, I will discuss how careful scrutiny of genetic skin disorders could help us to understand human biology. Like other organs, the skin and its appendages, such as hairs and teeth, experience fundamental biological processes ranging from lipid metabolism to vesicular transport and cellular migration. However, in contrast to other organ systems, they are accessible and can be studied with relative ease. By visually revealing the functional consequences of single gene defects, genetic skin diseases offer a unique opportunity to study human biology. Here, I will illustrate this concept by discussing how human genetic disorders of skin pigmentation reflect the mechanisms underlying this complex and vital process. Copyright © 2016 Elsevier Ltd. All rights reserved.

Dyads and triads at 35,000 feet - Factors affecting group process and aircrew performance

NASA Technical Reports Server (NTRS)

Foushee, H. C.

1984-01-01

The task of flying a multipilot transport aircraft is a classic small-group performance situation where a number of social, organizational, and personality factors are relevant to important outcome variables such as safety. The aviation community is becoming increasingly aware of the importance of these factors but is hampered in its efforts to improve the system because of research psychology's problems in defining the nature of the group process. This article identifies some of the problem areas as well as methods used to address these issues. It is argued that high fidelity flight simulators provide an environment that offers unique opportunities for work meeting both basic and applied research criteria.

Size matters: gold nanoparticles in targeted cancer drug delivery

PubMed Central

Dreaden, Erik C; Austin, Lauren A; Mackey, Megan A; El-Sayed, Mostafa A

2013-01-01

Cancer is the current leading cause of death worldwide, responsible for approximately one quarter of all deaths in the USA and UK. Nanotechnologies provide tremendous opportunities for multimodal, site-specific drug delivery to these disease sites and Au nanoparticles further offer a particularly unique set of physical, chemical and photonic properties with which to do so. This review will highlight some recent advances, by our laboratory and others, in the use of Au nanoparticles for systemic drug delivery to these malignancies and will also provide insights into their rational design, synthesis, physiological properties and clinical/preclinical applications, as well as strategies and challenges toward the clinical implementation of these constructs moving forward. PMID:22834077

Dyads and triads at 35,000 feet: Factors affecting group process and aircrew performance

NASA Technical Reports Server (NTRS)

Foushee, H. Clayton

1987-01-01

The task of flying a multipilot transport aircraft is a classic small-group performance situation where a number of social, organizational, and personality factors are relevant to important outcome variables such as safety. The aviation community is becoming increasingly aware of the importance of these factors but is hampered in its efforts to improve the system because of research psychology's problems in defining the nature of the group process. This article identifies some of the problem areas as well as methods used to address these issues. It is argued that high fidelity flight simulators provide an environment that offers unique opportunities for work meeting both basic and applied research criteria.

Reconstruction method for data protection in telemedicine systems

NASA Astrophysics Data System (ADS)

Buldakova, T. I.; Suyatinov, S. I.

2015-03-01

In the report the approach to protection of transmitted data by creation of pair symmetric keys for the sensor and the receiver is offered. Since biosignals are unique for each person, their corresponding processing allows to receive necessary information for creation of cryptographic keys. Processing is based on reconstruction of the mathematical model generating time series that are diagnostically equivalent to initial biosignals. Information about the model is transmitted to the receiver, where the restoration of physiological time series is performed using the reconstructed model. Thus, information about structure and parameters of biosystem model received in the reconstruction process can be used not only for its diagnostics, but also for protection of transmitted data in telemedicine complexes.

Human pluripotent stem cells: an emerging model in developmental biology.

PubMed

Zhu, Zengrong; Huangfu, Danwei

2013-02-01

Developmental biology has long benefited from studies of classic model organisms. Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and human induced pluripotent stem cells, have emerged as a new model system that offers unique advantages for developmental studies. Here, we discuss how studies of hPSCs can complement classic approaches using model organisms, and how hPSCs can be used to recapitulate aspects of human embryonic development 'in a dish'. We also summarize some of the recently developed genetic tools that greatly facilitate the interrogation of gene function during hPSC differentiation. With the development of high-throughput screening technologies, hPSCs have the potential to revolutionize gene discovery in mammalian development.

The Dioxin Crisis as Experiment To Determine Poultry-Related Campylobacter Enteritis

PubMed Central

Van Loock, Frank

2002-01-01

In June 1999, the dioxin crisis, caused by dioxin-contaminated feed components, exploded in Belgium, resulting in withdrawal of chicken and eggs from the market. Through the sentinel surveillance system, a decrease in Campylobacter infections during June 1999 was noticed. A model was generated with the reports from preceding years (1994 to 1998), and a prediction of the number of infections in 1999 was calculated. The model shows a significant decline (40%) in the number of infections, mainly because of the withdrawal of poultry. The use of a disaster as an epidemiologic tool offers a unique opportunity to observe exceptional changes in the occurrence of infections or other diseases. PMID:11749743

Integrated residential photovoltaic array development

NASA Technical Reports Server (NTRS)

Shepard, N. F., Jr.

1981-01-01

Three basic module design concepts were analyzed with respect to both production and installation costs. The results of this evaluation were used to synthesize a fourth design which incorporates the best features of these initial concepts to produce a module/array design approach which offers the promise of a substantial reduction in the installed cost of a residential array. A unique waterproofing and mounting scheme was used to reduce the cost of installing an integral array while still maintaining a high probability that the installed array will be watertight for the design lifetime of the system. This recommended concept will also permit the array to be mounted as a direct or stand-off installation with no changes to the module design.

Digital Astronaut Photography: A Discovery Dataset for Archaeology

NASA Technical Reports Server (NTRS)

Stefanov, William L.

2010-01-01

Astronaut photography acquired from the International Space Station (ISS) using commercial off-the-shelf cameras offers a freely-accessible source for high to very high resolution (4-20 m/pixel) visible-wavelength digital data of Earth. Since ISS Expedition 1 in 2000, over 373,000 images of the Earth-Moon system (including land surface, ocean, atmospheric, and lunar images) have been added to the Gateway to Astronaut Photography of Earth online database (http://eol.jsc.nasa.gov ). Handheld astronaut photographs vary in look angle, time of acquisition, solar illumination, and spatial resolution. These attributes of digital astronaut photography result from a unique combination of ISS orbital dynamics, mission operations, camera systems, and the individual skills of the astronaut. The variable nature of astronaut photography makes the dataset uniquely useful for archaeological applications in comparison with more traditional nadir-viewing multispectral datasets acquired from unmanned orbital platforms. For example, surface features such as trenches, walls, ruins, urban patterns, and vegetation clearing and regrowth patterns may be accentuated by low sun angles and oblique viewing conditions (Fig. 1). High spatial resolution digital astronaut photographs can also be used with sophisticated land cover classification and spatial analysis approaches like Object Based Image Analysis, increasing the potential for use in archaeological characterization of landscapes and specific sites.

WFIRST: Science in the Solar System

NASA Astrophysics Data System (ADS)

Milam, Stefanie N.; Holler, Bryan J.; Bauer, James M.; West, Robert; WFIRST Solar System Working Group

2018-01-01

Future space telescopes offer unprecedented sensitivity and spatial resolution at wavelengths that are inaccessible from the ground due to the Earth’s atmosphere, and will work in concert with future in situ robotic crafts and large ground-based facilities to address key questions for planetary science. Additionally, they provide broader perspectives in both targets and timelines for planetary missions that orbit, land, or fly by a given target. Space observatories are not constrained to a specific target, and provide global context as well as source-to-source comparisons that are not always achieved from directed missions.WFIRST will provide imaging and spectroscopic capabilities from 0.6-2.0 μm and will be a potential contemporary and eventual successor to JWST. Observations of asteroids, the giant planets and their satellites, Kuiper Belt Objects (KBOs), and comets will be possible through both the Guest Investigator (GI) and Guest Observer (GO) programs. Surveys of minor bodies and time domain studies of variable surfaces and atmospheres are uniquely well-suited for WFIRST with its 0.28 deg2 field of view (at ~0.11”/pixel). We will present our recent study of the capabilities for solar system science and highlight unique cases presented in the WFIRST white paper (arXiv: http://arxiv.org/abs/1709.02763).

Synchrotron-based X-ray microscopic studies for bioeffects of nanomaterials.

PubMed

Zhu, Ying; Cai, Xiaoqing; Li, Jiang; Zhong, Zengtao; Huang, Qing; Fan, Chunhai

2014-04-01

There have been increasing interests in studying biological effects of nanomaterials, which are nevertheless faced up with many challenges due to the nanoscale dimensions and unique chemical properties of nanomaterials. Synchrotron-based X-ray microscopy, an advanced imaging technology with high spatial resolution and excellent elemental specificity, provides a new platform for studying interactions between nanomaterials and living systems. In this article, we review the recent progress of X-ray microscopic studies on bioeffects of nanomaterials in several living systems including cells, model organisms, animals and plants. We aim to provide an overview of the state of the art, and the advantages of using synchrotron-based X-ray microscopy for characterizing in vitro and in vivo behaviors and biodistribution of nanomaterials. We also expect that the use of a combination of new synchrotron techniques should offer unprecedented opportunities for better understanding complex interactions at the nano-biological interface and accounting for unique bioeffects of nanomaterials. Synchrotron-based X-ray microscopy is a non-destructive imaging technique that enables high resolution spatial mapping of metals with elemental level detection methods. This review summarizes the current use and perspectives of this novel technique in studying the biology and tissue interactions of nanomaterials. Copyright © 2014 Elsevier Inc. All rights reserved.

A Path to Pattern.

PubMed

Kornberg, Thomas B

2016-01-01

The field of developmental biology is not the same one that I entered in 1975. At that time, it seemed that most of its practitioners used various kinds of microscopes to watch animals as they matured, described morphological details with impressive temporal and spatial resolution, and recorded responses to physical and genetic insults. The number of genes whose mutant phenotypes offered insights into developmental mechanisms was small, the expression and functionalities of these genes were unknown, and because the extent of evolutionary conservation between different animals or even different organs in the same animal was also unknown, the vocabularies that were used to describe development were unique to each system. The distance between the descriptors and inferred molecular mechanisms was vast; it was a descriptive discipline. Today genome sequences are available for the animals that developmental biologists study, saturation genetic screens are possible, transgenesis offers powerful ways to modify genomes, and the proteins that direct and implement developmental processes can be imaged in real time. These advances have transformed the field into one that merges with cell biology, physiology, neurobiology, and immunology, and they have transformed our understanding of development. In this essay, I offer my perspectives and my sense of some principles that have emerged. © 2016 Elsevier Inc. All rights reserved.

A Reserve-based Method for Mitigating the Impact of Renewable Energy

NASA Astrophysics Data System (ADS)

Krad, Ibrahim

The fundamental operating paradigm of today's power systems is undergoing a significant shift. This is partially motivated by the increased desire for incorporating variable renewable energy resources into generation portfolios. While these generating technologies offer clean energy at zero marginal cost, i.e. no fuel costs, they also offer unique operating challenges for system operators. Perhaps the biggest operating challenge these resources introduce is accommodating their intermittent fuel source availability. For this reason, these generators increase the system-wide variability and uncertainty. As a result, system operators are revisiting traditional operating strategies to more efficiently incorporate these generation resources to maximize the benefit they provide while minimizing the challenges they introduce. One way system operators have accounted for system variability and uncertainty is through the use of operating reserves. Operating reserves can be simplified as excess capacity kept online during real time operations to help accommodate unforeseen fluctuations in demand. With new generation resources, a new class of operating reserves has emerged that is generally known as flexibility, or ramping, reserves. This new reserve class is meant to better position systems to mitigate severe ramping in the net load profile. The best way to define this new requirement is still under investigation. Typical requirement definitions focus on the additional uncertainty introduced by variable generation and there is room for improvement regarding explicit consideration for the variability they introduce. An exogenous reserve modification method is introduced in this report that can improve system reliability with minimal impacts on total system wide production costs. Another potential solution to this problem is to formulate the problem as a stochastic programming problem. The unit commitment and economic dispatch problems are typically formulated as deterministic problems due to fast solution times and the solutions being sufficient for operations. Improvements in technical computing hardware have reignited interest in stochastic modeling. The variability of wind and solar naturally lends itself to stochastic modeling. The use of explicit reserve requirements in stochastic models is an area of interest for power system researchers. This report introduces a new reserve modification implementation based on previous results to be used in a stochastic modeling framework. With technological improvements in distributed generation technologies, microgrids are currently being researched and implemented. Microgrids are small power systems that have the ability to serve their demand with their own generation resources and may have a connection to a larger power system. As battery technologies improve, they are becoming a more viable option in these distributed power systems and research is necessary to determine the most efficient way to utilize them. This report will investigate several unique operating strategies for batteries in small power systems and analyze their benefits. These new operating strategies will help reduce operating costs and improve system reliability.

20 years of KVH fiber optic gyro technology: the evolution from large, low performance FOGs to compact, precise FOGs and FOG-based inertial systems

NASA Astrophysics Data System (ADS)

Napoli, Jay

2016-05-01

Precision fiber optic gyroscopes (FOGs) are critical components for an array of platforms and applications ranging from stabilization and pointing orientation of payloads and platforms to navigation and control for unmanned and autonomous systems. In addition, FOG-based inertial systems provide extremely accurate data for geo-referencing systems. Significant improvements in the performance of FOGs and FOG-based inertial systems at KVH are due, in large part, to advancements in the design and manufacture of optical fiber, as well as in manufacturing operations and signal processing. Open loop FOGs, such as those developed and manufactured by KVH Industries, offer tactical-grade performance in a robust, small package. The success of KVH FOGs and FOG-based inertial systems is due to innovations in key fields, including the development of proprietary D-shaped fiber with an elliptical core, and KVH's unique ThinFiber. KVH continually improves its FOG manufacturing processes and signal processing, which result in improved accuracies across its entire FOG product line. KVH acquired its FOG capabilities, including its patented E•Core fiber, when the company purchased Andrew Corporation's Fiber Optic Group in 1997. E•Core fiber is unique in that the light-guiding core - critical to the FOG's performance - is elliptically shaped. The elliptical core produces a fiber that has low loss and high polarization-maintaining ability. In 2010, KVH developed its ThinFiber, a 170-micron diameter fiber that retains the full performance characteristics of E•Core fiber. ThinFiber has enabled the development of very compact, high-performance open-loop FOGs, which are also used in a line of FOG-based inertial measurement units and inertial navigation systems.

Nuclear plants gain integrated information systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Villavicencio-Ramirez, A.; Rodriquez-Alvarez, J.M.

1994-10-01

With the objective of simplifying the complex mesh of computing devices employed within nuclear power plants, modern technology and integration techniques are being used to form centralized (but backed up) databases and distributed processing and display networks. Benefits are immediate as a result of the integration and the use of standards. The use of a unique data acquisition and database subsystem optimizes the high costs of engineering, as this task is done only once for the life span of the system. This also contributes towards a uniform user interface and allows for graceful expansion and maintenance. This article features anmore » integrated information system, Sistema Integral de Informacion de Proceso (SIIP). The development of this system enabled the Laguna Verde Nuclear Power plant to fully use the already existing universe of signals and its related engineering during all plant conditions, namely, start up, normal operation, transient analysis, and emergency operation. Integrated systems offer many advantages over segregated systems, and this experience should benefit similar development efforts in other electric power utilities, not only for nuclear but also for other types of generating plants.« less

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

PubMed Central

Kostrzewski, Tomasz; Sceats, Emma L

2017-01-01

Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge. The maintenance of functional primary hepatocytes cultures, the parenchymal cell of the liver, has historically been difficult with dedifferentiation and the consequent loss of hepatic function limiting utility. The desire for longer term functional liver cultures sparked the development of numerous systems, including collagen sandwiches, spheroids, micropatterned co-cultures and liver microphysiological systems. This review will focus on liver microphysiological systems, often referred to as liver-on-a-chip, and broaden to include platforms with interconnected microphysiological systems or multi-organ-chips. The interconnection of microphysiological systems presents the opportunity to explore system level effects, investigate organ cross talk, and address questions which were previously the preserve of animal experimentation. As a field, microphysiological systems have reached a level of maturity suitable for commercialization and consequent evaluation by a wider community of users, in academia and the pharmaceutical industry. Here scientific, operational, and organizational considerations relevant to the wider adoption of microphysiological systems will be discussed. Applications in which microphysiological systems might offer unique scientific insights or enable studies currently feasible only with animal models are described, and challenges which might be addressed to enable wider adoption of the technologies are highlighted. A path forward which envisions the development of microphysiological systems in partnerships between academia, vendors and industry, is proposed. Impact statement Microphysiological systems are in vitro models of human tissues and organs. These systems have advanced rapidly in recent years and are now being commercialized. To achieve wide adoption in the biological and pharmaceutical research communities, microphysiological systems must provide unique insights which translate to humans. This will be achieved by identifying key applications and making microphysiological systems intuitive to use. PMID:28504617

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems.

PubMed

Hughes, David J; Kostrzewski, Tomasz; Sceats, Emma L

2017-10-01

Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge. The maintenance of functional primary hepatocytes cultures, the parenchymal cell of the liver, has historically been difficult with dedifferentiation and the consequent loss of hepatic function limiting utility. The desire for longer term functional liver cultures sparked the development of numerous systems, including collagen sandwiches, spheroids, micropatterned co-cultures and liver microphysiological systems. This review will focus on liver microphysiological systems, often referred to as liver-on-a-chip, and broaden to include platforms with interconnected microphysiological systems or multi-organ-chips. The interconnection of microphysiological systems presents the opportunity to explore system level effects, investigate organ cross talk, and address questions which were previously the preserve of animal experimentation. As a field, microphysiological systems have reached a level of maturity suitable for commercialization and consequent evaluation by a wider community of users, in academia and the pharmaceutical industry. Here scientific, operational, and organizational considerations relevant to the wider adoption of microphysiological systems will be discussed. Applications in which microphysiological systems might offer unique scientific insights or enable studies currently feasible only with animal models are described, and challenges which might be addressed to enable wider adoption of the technologies are highlighted. A path forward which envisions the development of microphysiological systems in partnerships between academia, vendors and industry, is proposed. Impact statement Microphysiological systems are in vitro models of human tissues and organs. These systems have advanced rapidly in recent years and are now being commercialized. To achieve wide adoption in the biological and pharmaceutical research communities, microphysiological systems must provide unique insights which translate to humans. This will be achieved by identifying key applications and making microphysiological systems intuitive to use.

The Accounting Capstone Problem

ERIC Educational Resources Information Center

Elrod, Henry; Norris, J. T.

2012-01-01

Capstone courses in accounting programs bring students experiences integrating across the curriculum (University of Washington, 2005) and offer unique (Sanyal, 2003) and transformative experiences (Sill, Harward, & Cooper, 2009). Students take many accounting courses without preparing complete sets of financial statements. Accountants not only…

Commuter choice managers and parking managers coordination

DOT National Transportation Integrated Search

2002-11-01

Shared use park and ride represents a unique approach for addressing parking problems, and can offer substantial savings in land and development costs. One of the fundamental factors that determines the success of this approach is the level of coordi...

Application of Chemistry in Materials Research at NASA GRC

NASA Technical Reports Server (NTRS)

Kavandi, Janet L.

2016-01-01

Overview of NASA GRC Materials Development. New materials enabled by new chemistries offering unique properties and chemical processing techniques. Durability of materials in harsh environments requires understanding and modeling of chemical interaction of materials with the environment.

Selecting a Roof Membrane.

ERIC Educational Resources Information Center

Waldron, Larry W.

1990-01-01

Offers a brief synopsis of the unique characteristics of the following roof membranes: (1) built-up roofing; (2) elastoplastic membranes; (3) modified bitumen membranes; (4) liquid applied membranes; and (5) metal roofing. A chart compares the characteristics of the raw membranes only. (MLF)

Eco-morphological Real-time Forecasting tool to predict hydrodynamic, sediment and nutrient dynamic in Coastal Louisiana

NASA Astrophysics Data System (ADS)

Messina, F.; Meselhe, E. A.; Buckman, L.; Twight, D.

2017-12-01

Louisiana coastal zone is one of the most productive and dynamic eco-geomorphic systems in the world. This unique natural environment has been alternated by human activities and natural processes such as sea level rise, subsidence, dredging of canals for oil and gas production, the Mississippi River levees which don't allow the natural river sediment. As a result of these alterations land loss, erosion and flood risk are becoming real issues for Louisiana. Costal authorities have been studying the benefits and effects of several restoration projects, e.g. freshwater and sediment diversions. The protection of communities, wildlife and of the unique environments is a high priority in this region. The Water Institute of the Gulf, together with Deltares, has developed a forecasting and information system for a pilot location in Coastal Louisiana, specifically for Barataria Bay and Breton Sound Basins in the Mississippi River Deltaic Plain. The system provides a 7-day forecast of water level, salinity, and temperature, under atmospheric and coastal forecasted conditions, such as freshwater riverine inflow, rainfall, evaporation, wind, and tide. The system also forecasts nutrient distribution (e.g., Chla and dissolved oxygen) and sediment transport. The Flood Early Warning System FEWS is used as a platform to import multivariate data from several sources, use them to monitor the pilot location and to provide boundary conditions to the model. A hindcast model is applied to compare the model results to the observed data, and to provide the initial condition to the forecast model. This system represents a unique tool which provides valuable information regarding the overall conditions of the basins. It offers the opportunity to adaptively manage existing and planned diversions to meet certain salinity and water level targets or thresholds while maximizing land-building goals. Moreover, water quality predictions provide valuable information on the current ecological conditions of the area. Real time observations and model predictions can be used as guidance to decision makers regarding the operation of control structures in response to forecasted weather or river flood events. Coastal communities can benefit from water level, salinity and water quality forecast to manage their activities.

The Vulnerabilities of Orphaned Children Participating in Research: A Critical Review and Factors for Consideration for Participation in Biomedical and Behavioral Research

PubMed Central

Thompson, Rachel T.; Meslin, Eric M.; Braitstein, Paula K. A.; Nyandiko, Winstone M.; Ayaya, Samuel O.; Vreeman, Rachel C.

2013-01-01

Orphans are a subpopulation with a unique set of additional vulnerabilities. Increasing focus on children’s rights, pediatric global health, and pediatric research makes it imperative to recognize and address unique vulnerabilities of orphaned children. This paper describes the unique vulnerabilities of the orphaned pediatric population and offers a structured set of factors that require consideration when including orphans in biomedical research. Pediatric orphans are particularly vulnerable due to decreased economic resources, psychosocial instability, increased risk of abuse, and delayed/decreased access to healthcare. These vulnerabilities are significant. By carefully considering each issue in a population in a culturally specific and study-specific manner, researchers can make valuable contributions to the overall health and well-being of this uniquely vulnerable population. PMID:23086048

Systematic and Open Identification of Researchers and Authors: Focus on Open Researcher and Contributor ID

PubMed Central

Akazhanov, Nurbek A.; Voronov, Alexander A.; Kitas, George D.

2014-01-01

Unique identifiers of researchers and authors can help all stakeholders of scientific communications improve their workflows. There have been several attempts to establish professional networks of scholars and list their scholarly achievements on digital platforms. Some of these platforms such as Google Scholar, Web of Knowledge and PubMed are searched to pick relevant peer reviewers, assess authors' publication history or choose suitable candidates for research and academic projects. However, each of these hubs has its specific applications, limiting the universal use for permanent tagging of researcher profiles. The Open Researcher and Contributor ID (ORCID) initiative, launched in 2012, is aimed at registering scholarly contributors and averting the persistent ambiguity of recorded author names. The ORCID registry is growing fast and integrating with other ID-generating platforms, thereby increasing the functionality of the integrated systems. ORCID identifiers are increasingly used for selecting peer reviewers and acknowledging various scholarly contributions (e.g., published articles, reviewer comments, conference presentations). The initiative offers unique opportunities for transparent disclosures of author contributions and competing interests and improving ethical standards of research, editing, and publishing. PMID:25408574

Systematic and open identification of researchers and authors: focus on open researcher and contributor ID.

PubMed

Gasparyan, Armen Yuri; Akazhanov, Nurbek A; Voronov, Alexander A; Kitas, George D

2014-11-01

Unique identifiers of researchers and authors can help all stakeholders of scientific communications improve their workflows. There have been several attempts to establish professional networks of scholars and list their scholarly achievements on digital platforms. Some of these platforms such as Google Scholar, Web of Knowledge and PubMed are searched to pick relevant peer reviewers, assess authors' publication history or choose suitable candidates for research and academic projects. However, each of these hubs has its specific applications, limiting the universal use for permanent tagging of researcher profiles. The Open Researcher and Contributor ID (ORCID) initiative, launched in 2012, is aimed at registering scholarly contributors and averting the persistent ambiguity of recorded author names. The ORCID registry is growing fast and integrating with other ID-generating platforms, thereby increasing the functionality of the integrated systems. ORCID identifiers are increasingly used for selecting peer reviewers and acknowledging various scholarly contributions (e.g., published articles, reviewer comments, conference presentations). The initiative offers unique opportunities for transparent disclosures of author contributions and competing interests and improving ethical standards of research, editing, and publishing.

Clinical implications of drug abuse epidemiology.

PubMed

Schulden, Jeffrey D; Lopez, Marsha F; Compton, Wilson M

2012-06-01

Research on the epidemiology of illicit drug use disorders provides continued critical insights into the distribution and determinants of drug use and drug use disorders in the United States. This research serves as a foundation for understanding the etiology of these disorders, helping to disentangle the complex interrelationship of developmental, genetic, and environmental risk and protective factors. Building on an understanding of this research in substance abuse epidemiology, it is important for clinicians to understand the unique trends in drug use in the overall communities that they serve and the unique risk factors for given individuals. The generally high prevalence of substance use disorders, along with their high comorbidity with other psychiatric disorders and with the HIV epidemic, make prevention, evaluation, and referral for treatment for drug abuse an important part of routine clinical practice in a range of clinical settings, including primary care, psychiatric, and emergency department settings. Ongoing efforts to ensure insurance coverage parity for the treatment of mental health and substance use disorders offer the promise of continued improvements in the integration and availability of such services in the broader US health care system.

In vitro pathological modelling using patient-specific induced pluripotent stem cells: the case of progeria.

PubMed

Nissan, Xavier; Blondel, Sophie; Peschanski, Marc

2011-12-01

Progeria, also known as HGPS (Hutchinson-Gilford progeria syndrome), is a rare fatal genetic disease characterized by an appearance of accelerated aging in children. This syndrome is typically caused by mutations in codon 608 (C1804T) of the gene encoding lamins A and C, LMNA, leading to the production of a truncated form of the protein called progerin. Owing to their unique potential to self-renew and to differentiate into any cell types of the organism, pluripotent stem cells offer a unique tool to study molecular and cellular mechanisms related to this global and systemic disease. Recent studies have exploited this potential by generating human induced pluripotent stem cells from HGPS patients' fibroblasts displaying several phenotypic defects characteristic of HGPS such as nuclear abnormalities, progerin expression, altered DNA-repair mechanisms and premature senescence. Altogether, these findings provide new insights on the use of pluripotent stem cells for pathological modelling and may open original therapeutic perspectives for diseases that lack pre-clinical in vitro human models, such as HGPS.

Comparison of Effectiveness of Computer Graded vs Instructor Graded Homework Assignments in an Elementary Spanish Course: A Comparative Study at Two Undergraduate Institutions

DTIC Science & Technology

2012-03-07

technology, that being the instructor-graded versus computer-graded activities. In essence, the study came to be about how diverse student bodies reacted...terms of student body and academic offerings, Metropolitan State College of Denver (Metro State) is a unique institution in Colorado and the United...slate of baccalaureate degree offerings. Metro State’s student body of over 24,000 is an exemplar of diversity. The institution admits students via a

Dynamical sensitivity control of a single-spin quantum sensor.

PubMed

Lazariev, Andrii; Arroyo-Camejo, Silvia; Rahane, Ganesh; Kavatamane, Vinaya Kumar; Balasubramanian, Gopalakrishnan

2017-07-26

The Nitrogen-Vacancy (NV) defect in diamond is a unique quantum system that offers precision sensing of nanoscale physical quantities at room temperature beyond the current state-of-the-art. The benchmark parameters for nanoscale magnetometry applications are sensitivity, spectral resolution, and dynamic range. Under realistic conditions the NV sensors controlled by conventional sensing schemes suffer from limitations of these parameters. Here we experimentally show a new method called dynamical sensitivity control (DYSCO) that boost the benchmark parameters and thus extends the practical applicability of the NV spin for nanoscale sensing. In contrast to conventional dynamical decoupling schemes, where π pulse trains toggle the spin precession abruptly, the DYSCO method allows for a smooth, analog modulation of the quantum probe's sensitivity. Our method decouples frequency selectivity and spectral resolution unconstrained over the bandwidth (1.85 MHz-392 Hz in our experiments). Using DYSCO we demonstrate high-accuracy NV magnetometry without |2π| ambiguities, an enhancement of the dynamic range by a factor of 4 · 10 3 , and interrogation times exceeding 2 ms in off-the-shelf diamond. In a broader perspective the DYSCO method provides a handle on the inherent dynamics of quantum systems offering decisive advantages for NV centre based applications notably in quantum information and single molecule NMR/MRI.

Enzyme-regulated the changes of pH values for assembling a colorimetric and multistage interconnection logic network with multiple readouts.

PubMed

Huang, Yanyan; Ran, Xiang; Lin, Youhui; Ren, Jinsong; Qu, Xiaogang

2015-04-22

Based on enzymatic reactions-triggered changes of pH values and biocomputing, a novel and multistage interconnection biological network with multiple easy-detectable signal outputs has been developed. Compared with traditional chemical computing, the enzyme-based biological system could overcome the interference between reactions or the incompatibility of individual computing gates and offer a unique opportunity to assemble multicomponent/multifunctional logic circuitries. Our system included four enzyme inputs: β-galactosidase (β-gal), glucose oxidase (GOx), esterase (Est) and urease (Ur). With the assistance of two signal transducers (gold nanoparticles and acid-base indicators) or pH meter, the outputs of the biological network could be conveniently read by the naked eyes. In contrast to current methods, the approach present here could realize cost-effective, label-free and colorimetric logic operations without complicated instrument. By designing a series of Boolean logic operations, we could logically make judgment of the compositions of the samples on the basis of visual output signals. Our work offered a promising paradigm for future biological computing technology and might be highly useful in future intelligent diagnostics, prodrug activation, smart drug delivery, process control, and electronic applications. Copyright © 2015 Elsevier B.V. All rights reserved.

European distributed seismological data archives infrastructure: EIDA

NASA Astrophysics Data System (ADS)

Clinton, John; Hanka, Winfried; Mazza, Salvatore; Pederson, Helle; Sleeman, Reinoud; Stammler, Klaus; Strollo, Angelo

2014-05-01

The European Integrated waveform Data Archive (EIDA) is a distributed Data Center system within ORFEUS that (a) securely archives seismic waveform data and related metadata gathered by European research infrastructures, and (b) provides transparent access to the archives for the geosciences research communities. EIDA was founded in 2013 by ORFEUS Data Center, GFZ, RESIF, ETH, INGV and BGR to ensure sustainability of a distributed archive system and the implementation of standards (e.g. FDSN StationXML, FDSN webservices) and coordinate new developments. Under the mandate of the ORFEUS Board of Directors and Executive Committee the founding group is responsible for steering and maintaining the technical developments and organization of the European distributed seismic waveform data archive and the integration within broader multidisciplanry frameworks like EPOS. EIDA currently offers uniform data access to unrestricted data from 8 European archives (www.orfeus-eu.org/eida), linked by the Arclink protocol, hosting data from 75 permanent networks (1800+ stations) and 33 temporary networks (1200+) stations). Moreover, each archive may also provide unique, restricted datasets. A webinterface, developed at GFZ, offers interactive access to different catalogues (EMSC, GFZ, USGS) and EIDA waveform data. Clients and toolboxes like arclink_fetch and ObsPy can connect directly to any EIDA node to collect data. Current developments are directed to the implementation of quality parameters and strong motion parameters.

DigiLens color sequential filtering for microdisplay-based projection applications

NASA Astrophysics Data System (ADS)

Sagan, Stephen F.; Smith, Ronald T.; Popovich, Milan M.

2000-10-01

Application Specific Integrated Filters (ASIFs), based on a unique holographic polymer dispersed liquid crystal (H-PDLC) material system offering high efficiency, fast switching and low power, are being developed for microdisplay based projection applications. A new photonics technology based H-PDLC materials combined with the ability to be electrically switched on and off offers a new approach to color sequential filtering of a white light source for microdisplay-based front and rear projection display applications. Switchable Bragg gratings created in the PDLC are fundamental building blocks. Combined with the well- defined spectral and angular characteristics of Bragg gratings, these selectable filters can provide a large color gamut and a dynamically adjustable white balance. These switchable Bragg gratings can be reflective or transmissive and in each case can be designed to operate in either additive or subtractive mode. The spectral characteristics of filters made from a stack of these Bragg gratings can be configured for a specific lamp spectrum to give high diffractive efficiency over the broad bandwidths required for an illumination system. When it is necessary to reduce the spectral bandwidth, it is possible to use the properties of reflection Bragg holograms to construct very narrow band high efficiency filters. The basic properties and key benefits of ASIFs in projection displays are reviewed.

Support for global science: Remote sensing's challenge

NASA Technical Reports Server (NTRS)

Estes, J. E.; Star, J. L.

1986-01-01

Remote sensing uses a wide variety of techniques and methods. Resulting data are analyzed by man and machine, using both analog and digital technology. The newest and most important initiatives in the U. S. civilian space program currently revolve around the space station complex, which includes the core station as well as co-orbiting and polar satellite platforms. This proposed suite of platforms and support systems offers a unique potential for facilitating long term, multidisciplinary scientific investigations on a truly global scale. Unlike previous generations of satellites, designed for relatively limited constituencies, the space station offers the potential to provide an integrated source of information which recognizes the scientific interest in investigating the dynamic coupling between the oceans, land surface, and atmosphere. Earth scientist already face problems that are truly global in extent. Problems such as the global carbon balance, regional deforestation, and desertification require new approaches, which combine multidisciplinary, multinational research teams, employing advanced technologies to produce a type, quantity, and quality of data not previously available. The challenge before the international scientific community is to continue to develop both the infrastructure and expertise to, on the one hand, develop the science and technology of remote sensing, while on the other hand, develop an integrated understanding of global life support systems, and work toward a quantiative science of the biosphere.

Bioinspired magnetoreception and navigation using magnetic signatures as waypoints.

PubMed

Taylor, Brian K

2018-05-15

Diverse taxa use Earth's magnetic field in conjunction with other sensory modalities to accomplish navigation tasks ranging from local homing to long-distance migration across continents and ocean basins. However, despite extensive research, the mechanisms that underlie animal magnetoreception are not clearly understood, and how animals use Earth's magnetic field to navigate is an active area of investigation. Concurrently, Earth's magnetic field offers a signal that engineered systems can leverage for navigation in environments where man-made systems such as GPS are unavailable or unreliable. Using a proxy for Earth's magnetic field, and inspired by migratory animal behavior, this work implements a behavioral strategy that uses combinations of magnetic field properties as rare or unique signatures that mark specific locations. Using a discrete number of these signatures as goal waypoints, the strategy navigates through a closed set of points several times in a variety of environmental conditions, and with various levels of sensor noise. The results from this engineering/quantitative biology approach support existing notions that some animals may use combinations of magnetic properties as navigational markers, and provides insights into features and constraints that would enable navigational success or failure. The findings also offer insights into how autonomous engineered platforms might be designed to leverage the magnetic field as a navigational resource.

Institutional food as a lever for improving health in cities: the case of New York City.

PubMed

Tsui, E K; Wurwarg, J; Poppendieck, J; Deutsch, J; Freudenberg, N

2015-04-01

To describe and examine the factors that most facilitate and impede the provision of healthy foods in a complex institutional food system. Comparative case study of three institutional food settings in New York City. Document review and interviews with relevant city government staff. Factors that facilitate and impede the provision of healthy food vary across institutional food settings, and particularly between centralized and decentralized settings. Generally pro-health factors include centralized purchasing and the ability to work with vendors to formulate items to improve nutritional quality, though decentralized purchasing may offer more flexibility to work with vendors offering healthier food items and to respond to consumer preferences. Factors most often working against health in more centralized systems include financing constraints that are unique to particular settings. In less centralized systems, factors working against health may include both financing constraints and factors that are site-specific, relating to preparation and equipment. Making changes to institutional food systems that will meaningfully influence public health requires a detailed understanding of the diverse systems supporting and shaping public food provision. Ultimately, the cases in this study demonstrate that agency staff typically would like to provide healthier foods, but often feel limited by the competing objectives of affordability and consumer preference. Their ability to address these competing objectives is shaped by a combination of both forces external to the institution, like nutritional regulations, and internal forces, like an agency's structure, and motivation on the part of staff. Copyright © 2014 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

The Biosynthesis of Unusual Floral Volatiles and Blends Involved in Orchid Pollination by Deception: Current Progress and Future Prospects.

PubMed

Wong, Darren C J; Pichersky, Eran; Peakall, Rod

2017-01-01

Flowers have evolved diverse strategies to attract animal pollinators, with visual and olfactory floral cues often crucial for pollinator attraction. While most plants provide reward (e.g., nectar, pollen) in return for the service of pollination, 1000s of plant species, particularly in the orchid family, offer no apparent reward. Instead, they exploit their often specific pollinators (one or few) by mimicking signals of female insects, food source, and oviposition sites, among others. A full understanding of how these deceptive pollination strategies evolve and persist remains an open question. Nonetheless, there is growing evidence that unique blends that often contain unusual compounds in floral volatile constituents are often employed to secure pollination by deception. Thus, the ability of plants to rapidly evolve new pathways for synthesizing floral volatiles may hold the key to the widespread evolution of deceptive pollination. Yet, until now the biosynthesis of these volatile compounds has been largely neglected. While elucidating the biosynthesis in non-model systems is challenging, nonetheless, these cases may also offer untapped potential for biosynthetic breakthroughs given that some of the compounds can be exclusive or dominant components of the floral scent and production is often tissue-specific. In this perspective article, we first highlight the chemical diversity underpinning some of the more widespread deceptive orchid pollination strategies. Next, we explore the potential metabolic pathways and biosynthetic steps that might be involved. Finally, we offer recommendations to accelerate the discovery of the biochemical pathways in these challenging but intriguing systems.

The Biosynthesis of Unusual Floral Volatiles and Blends Involved in Orchid Pollination by Deception: Current Progress and Future Prospects

PubMed Central

Wong, Darren C. J.; Pichersky, Eran; Peakall, Rod

2017-01-01

Flowers have evolved diverse strategies to attract animal pollinators, with visual and olfactory floral cues often crucial for pollinator attraction. While most plants provide reward (e.g., nectar, pollen) in return for the service of pollination, 1000s of plant species, particularly in the orchid family, offer no apparent reward. Instead, they exploit their often specific pollinators (one or few) by mimicking signals of female insects, food source, and oviposition sites, among others. A full understanding of how these deceptive pollination strategies evolve and persist remains an open question. Nonetheless, there is growing evidence that unique blends that often contain unusual compounds in floral volatile constituents are often employed to secure pollination by deception. Thus, the ability of plants to rapidly evolve new pathways for synthesizing floral volatiles may hold the key to the widespread evolution of deceptive pollination. Yet, until now the biosynthesis of these volatile compounds has been largely neglected. While elucidating the biosynthesis in non-model systems is challenging, nonetheless, these cases may also offer untapped potential for biosynthetic breakthroughs given that some of the compounds can be exclusive or dominant components of the floral scent and production is often tissue-specific. In this perspective article, we first highlight the chemical diversity underpinning some of the more widespread deceptive orchid pollination strategies. Next, we explore the potential metabolic pathways and biosynthetic steps that might be involved. Finally, we offer recommendations to accelerate the discovery of the biochemical pathways in these challenging but intriguing systems. PMID:29181016

SU-F-T-146: Comparing Monte Carlo Simulations with Commissioning Beam Data for Mevion S250 Proton Therapy System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prusator, M; Jin, H; Ahmad, S

2016-06-15

Purpose: To evaluate the Monte Carlo simulated beam data with the measured commissioning data for the Mevion S250 proton therapy system. Method: The Mevion S250 proton therapy system utilizes a passive double scattering technique with a unique gantry mounted superconducting accelerator and offers effective proton therapy in a compact design concept. The field shaping system (FSS) includes first scattering foil, range modulator wheel (RMW), second scattering foil and post absorber and offers two field sizes and a total of 24 treatment options from proton range of 5 cm to 32 cm. The treatment nozzle was modeled in detail using TOPASmore » (TOolkit for PArticle Simulation) Monte Carlo code. The timing feathers of the moving modulator wheels were also implemented to generate the Spread Out Bragg Peak (SOBP). The simulation results including pristine Bragg Peak, SOBP and dose profiles were compared with the data measured during beam commissioning. Results: The comparison between the measured data and the simulation data show excellent agreement. For pristine proton Bragg Peaks, the simulated proton range (depth of distal 90%) values agreed well with the measured range values within 1 mm accuracy. The differences of the distal falloffs (depth from distal 80% to 20%) were also found to be less than 1 mm between the simulations and measurements. For the SOBP, the widths of modulation (depth of proximal 95% to distal 90%) were also found to agree with the measurement within 1 mm. The flatness of the simulated and measured lateral profiles was found to be 0.6 % and 1.1 %, respectively. Conclusion: The agreement between simulations and measurements demonstrate that TOPAS could be used as a viable platform to proton therapy applications. The matched simulation results offer a great tool and open opportunity for variety of applications.« less

So, Here's the Story

ERIC Educational Resources Information Center

Columba, Lynn

2013-01-01

Mathematics is about reasoning, patterns, and making sense of things. Children's literature provides a powerful opportunity to foster unique experiences in mathematics learning. Storybooks, thinking strategies, and manipulatives offer a winning combination for mastering multiplication facts based on conceptual ideas and relationships. The most…

Health monitoring of post-tension tendons in bridges.

DOT National Transportation Integrated Search

2003-01-01

Post-tensioned concrete has been used in a number of bridge structures and is expected to be used more in future construction in Virginia. This type of detail offers unique advantages for improving the performance of concrete members. Recent problems...

UV lasers for drilling and marking applications.

PubMed

Hannon, T

1999-10-01

Lasers emitting ultraviolet (UV) light have unique capabilities for precision micromachining and marking plastic medical devices. This review of the benefits offered by laser technology includes a look at recently developed UV diode-pumped solid-state lasers and their key features.

Vocational/Industrial Arts.

ERIC Educational Resources Information Center

American School & University, 2003

2003-01-01

Presents high school and college vocational/industrial arts buildings considered outstanding in a competition, which judged the most outstanding learning environments at educational institutions nationwide. Jurors spent two days reviewing projects, highlighting unique concepts and ideas. For each citation, the article offers information on the…

Nanocrystalline cellulose from coir fiber: preparation, properties, and applications

USDA-ARS?s Scientific Manuscript database

Nanocrystalline cellulose derived from various botanical sources offers unique and potentially useful characteristics. In principle, any cellulosic material can be considered as a potential source of a nanocrystalline material, including crops, crop residues, and agroindustrial wastes. Because of t...

Price Advice: Counseling Alumni About the Cost of an Education.

ERIC Educational Resources Information Center

Wynn, G. Richard; Morrell, Louis R.

1999-01-01

In excerpts from alumni magazines, the treasurers of Haverford College (Pennsylvania) and Wake Forest University (North Carolina) communicate issues involved in setting tuition and offer unique approaches to explaining the value that students receive at these private institutions. (MSE)

Gender Development

ERIC Educational Resources Information Center

Owen Blakemore, Judith E.; Berenbaum, Sheri A.; Liben, Lynn S.

2008-01-01

This new text offers a unique developmental focus on gender. Gender development is examined from infancy through adolescence, integrating biological, socialization, and cognitive perspectives. The book's current empirical focus is complemented by a lively and readable style that includes anecdotes about children's everyday experiences. The book's…

Bottom-up design of de novo thermoelectric hybrid materials using chalcogenide resurfacing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sahu, Ayaskanta; Russ, Boris; Su, Norman C.

Hybrid organic/inorganic thermoelectric materials based on conducting polymers and inorganic nanostructures have been demonstrated to combine both the inherently low thermal conductivity of the polymer and the superior charge transport properties (high power factors) of the inorganic component. While their performance today still lags behind that of conventional inorganic thermoelectric materials, solution-processable hybrids have made rapid progress and also offer unique advantages not available to conventional rigid inorganic thermoelectrics, namely: (1) low cost fabrication on rigid and flexible substrates, as well as (2) engineering complex conformal geometries for energy harvesting/cooling. While the number of reports of new classes of viablemore » hybrid thermoelectric materials is growing, no group has reported a general approach for bottom-up design of both p- and n-type materials from one common base. Thus, unfortunately, the literature comprises mostly of disconnected discoveries, which limits development and calls for a first-principles approach for property manipulation analogous to doping in traditional semiconductor thermoelectrics. Here, molecular engineering at the organic/inorganic interface and simple processing techniques are combined to demonstrate a modular approach enabling de novo design of complex hybrid thermoelectric systems. Here, we chemically modify the surfaces of inorganic nanostructures and graft conductive polymers to yield robust solution processable p- and n-type inorganic/organic hybrid nanostructures. Our new modular approach not only offers researchers new tools to perform true bottom-up design of thermoelectric hybrids, but also strong performance advantages as well due to the quality of the designed interfaces. For example, we obtain enhanced power factors in existing (by up to 500% in Te/PEDOT:PSS) and novel (Bi 2S 3/PEDOT:PSS) p-type systems, and also generate water-processable and air-stable high performing n-type hybrid systems (Bi 2Te 3/PEDOT:PSS), thus highlighting the potency of our ex situ strategy in opening up new material options for thermoelectric applications. Finally, this strategy establishes a unique platform with broad handles for custom tailoring of thermal and electrical properties through hybrid material tunability and enables independent control over inorganic material chemistry, nanostructure geometry, and organic material properties, thus providing a robust pathway to major performance enhancements.« less

Bottom-up design of de novo thermoelectric hybrid materials using chalcogenide resurfacing

DOE PAGES

Sahu, Ayaskanta; Russ, Boris; Su, Norman C.; ...

2017-01-01

Hybrid organic/inorganic thermoelectric materials based on conducting polymers and inorganic nanostructures have been demonstrated to combine both the inherently low thermal conductivity of the polymer and the superior charge transport properties (high power factors) of the inorganic component. While their performance today still lags behind that of conventional inorganic thermoelectric materials, solution-processable hybrids have made rapid progress and also offer unique advantages not available to conventional rigid inorganic thermoelectrics, namely: (1) low cost fabrication on rigid and flexible substrates, as well as (2) engineering complex conformal geometries for energy harvesting/cooling. While the number of reports of new classes of viablemore » hybrid thermoelectric materials is growing, no group has reported a general approach for bottom-up design of both p- and n-type materials from one common base. Thus, unfortunately, the literature comprises mostly of disconnected discoveries, which limits development and calls for a first-principles approach for property manipulation analogous to doping in traditional semiconductor thermoelectrics. Here, molecular engineering at the organic/inorganic interface and simple processing techniques are combined to demonstrate a modular approach enabling de novo design of complex hybrid thermoelectric systems. Here, we chemically modify the surfaces of inorganic nanostructures and graft conductive polymers to yield robust solution processable p- and n-type inorganic/organic hybrid nanostructures. Our new modular approach not only offers researchers new tools to perform true bottom-up design of thermoelectric hybrids, but also strong performance advantages as well due to the quality of the designed interfaces. For example, we obtain enhanced power factors in existing (by up to 500% in Te/PEDOT:PSS) and novel (Bi 2S 3/PEDOT:PSS) p-type systems, and also generate water-processable and air-stable high performing n-type hybrid systems (Bi 2Te 3/PEDOT:PSS), thus highlighting the potency of our ex situ strategy in opening up new material options for thermoelectric applications. Finally, this strategy establishes a unique platform with broad handles for custom tailoring of thermal and electrical properties through hybrid material tunability and enables independent control over inorganic material chemistry, nanostructure geometry, and organic material properties, thus providing a robust pathway to major performance enhancements.« less

How small business health exchanges can offer value to their future customers--and why they must.

PubMed

Kingsdale, Jon

2012-02-01

The success of the Small Business Health Options Program (SHOP)-health insurance exchanges targeted at the small-group market and opening for business in January 2014-will depend in large part on persuading small employers and qualified health plans to participate. The most important objective will be offering employers lower-cost health plans than they have now. Other critical objectives will be offering small firms administrative efficiencies and access to choices among high-value plans that are not offered elsewhere. This article frames the challenges that exchanges will encounter in meeting these objectives. In particular, it discusses the advisability of small-business exchanges' offering an "employee choice" model (which the article describes in detail); of combining the small-business and individual exchanges to broaden product offerings and gain operational efficiencies; and of encouraging low-cost plans to enter the exchange market, perhaps by enabling Medicaid managed care plans to offer comparable commercial products, and in turn affording health plans access to a uniquely motivated market of small firms and their workers who want affordable coverage.

Making Sense of Plant Health

NASA Technical Reports Server (NTRS)

2001-01-01

Ciencia, Inc. created a new device, known as a Portable Photosynthesis Analyzer, or Phase Fluorometer, that provides real-time data about the photochemical efficiency of phytoplankton and other plant forms. The commercial version of this technology is used for photosynthesis research and offers major benefits to the field of life science. This new instrument is the first portable instrument of its kind. Through a license agreement with Ciencia, Oriel Instruments, of Stratford, Connecticut, manufactures and markets the commercial version of the instrument under the name LifeSense.TMLifeSense is a 70 MHz single-frequency fluorometer that offers unrivaled capabilities for fluorescence lifetime sensing and analysis. LifeSense provides information about all varieties of photosynthetic systems. Photosynthesis research contributes important health assessments about the plant, be it phytoplankton or a higher form of plant life. With its unique sensing capabilities, LifeSense furnishes data regarding the yield of a plant's photochemistry, as well as its levels of photosynthetic activity. The user can then gain an extremely accurate estimate of the plant's chlorophyll biomass, primary production rates, and a general overview of the plant's physiological condition.

Teachers guide for building and operating weather satellite ground stations for high school science

NASA Technical Reports Server (NTRS)

Summers, R. J.; Gotwald, T.

1981-01-01

A number of colleges and universities are operating APT direct readout stations. However, high school science teachers have often failed to realize the potential of meteorological satellites and their products as unique instructional tools. The ability to receive daily pictures from these satellites offers exciting opportunities for secondary school teachers and students to assemble the electronic hardware and to view real time pictures of Earth from outer space. The station and pictures can be used in the classroom to develop an approach to science teaching that could span many scientific disciplines and offer many opportunities for student research and participation in scientific processes. This can be accomplished with relatively small expenditures of funds for equipment. In most schools some of the equipment may already be available. Others can be constructed by teachers and/or students. Yet another source might be the purchase of used equipment from industry or through the government surplus channels. The information necessary for individuals unfamiliar with these systems to construct a direct readout for receiving real time APT photographs on a daily basis in the classroom is presented.

Graphene/graphene oxide and their derivatives in the separation/isolation and preconcentration of protein species: A review.

PubMed

Chen, Xuwei; Hai, Xin; Wang, Jianhua

2016-05-30

The distinctive/unique electrical, chemical and optical properties make graphene/graphene oxide-based materials popular in the field of analytical chemistry. Its large surface offers excellent capacity to anchor target analyte, making it an powerful sorbent in the adsorption and preconcentration of trace level analyte of interest in the field of sample preparation. The large delocalized π-electron system of graphene framework provides strong affinity to species containing aromatic rings, such as proteins, and the abundant active sites on its surface offers the chance to modulate adsorption tendency towards specific protein via functional modification/decoration. This review provides an overview of the current research on graphene/graphene oxide-based materials as attractive and powerful adsorption media in the separation/isolation and preconcentration of protein species from biological sample matrixes. These practices are aiming at providing protein sample of high purity for further investigations and applications, or to achieve certain extent of enrichment prior to quantitative assay. In addition, the challenges and future perspectives in the related research fields have been discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

PuffinPlot: A versatile, user-friendly program for paleomagnetic analysis

NASA Astrophysics Data System (ADS)

Lurcock, P. C.; Wilson, G. S.

2012-06-01

PuffinPlot is a user-friendly desktop application for analysis of paleomagnetic data, offering a unique combination of features. It runs on several operating systems, including Windows, Mac OS X, and Linux; supports both discrete and long core data; and facilitates analysis of very weakly magnetic samples. As well as interactive graphical operation, PuffinPlot offers batch analysis for large volumes of data, and a Python scripting interface for programmatic control of its features. Available data displays include demagnetization/intensity, Zijderveld, equal-area (for sample, site, and suite level demagnetization data, and for magnetic susceptibility anisotropy data), a demagnetization data table, and a natural remanent magnetization intensity histogram. Analysis types include principal component analysis, Fisherian statistics, and great-circle path intersections. The results of calculations can be exported as CSV (comma-separated value) files; graphs can be printed, and can also be saved as publication-quality vector files in SVG or PDF format. PuffinPlot is free, and the program, user manual, and fully documented source code may be downloaded from http://code.google.com/p/puffinplot/.

Towards ambient temperature-stable vaccines: the identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay.

PubMed

Schlehuber, Lisa D; McFadyen, Iain J; Shu, Yu; Carignan, James; Duprex, W Paul; Forsyth, William R; Ho, Jason H; Kitsos, Christine M; Lee, George Y; Levinson, Douglas A; Lucier, Sarah C; Moore, Christopher B; Nguyen, Niem T; Ramos, Josephine; Weinstock, B André; Zhang, Junhong; Monagle, Julie A; Gardner, Colin R; Alvarez, Juan C

2011-07-12

As a result of thermal instability, some live attenuated viral (LAV) vaccines lose substantial potency from the time of manufacture to the point of administration. Developing regions lacking extensive, reliable refrigeration ("cold-chain") infrastructure are particularly vulnerable to vaccine failure, which in turn increases the burden of disease. Development of a robust, infectivity-based high throughput screening process for identifying thermostable vaccine formulations offers significant promise for vaccine development across a wide variety of LAV products. Here we describe a system that incorporates thermal stability screening into formulation design using heat labile measles virus as a prototype. The screening of >11,000 unique formulations resulted in the identification of liquid formulations with marked improvement over those used in commercial monovalent measles vaccines, with <1.0 log loss of activity after incubation for 8h at 40°C. The approach was shown to be transferable to a second unrelated virus, and therefore offers significant promise towards the optimization of formulation for LAV vaccine products. Copyright © 2011 Elsevier Ltd. All rights reserved.

Stretched Lens Array Squarerigger (SLASR) Technology Maturation

NASA Technical Reports Server (NTRS)

O'Neill, Mark; McDanal, A.J.; Howell, Joe; Lollar, Louis; Carrington, Connie; Hoppe, David; Piszczor, Michael; Suszuki, Nantel; Eskenazi, Michael; Aiken, Dan;

Prolonged Instability Prior to a Regime Shift | Science ...

EPA Pesticide Factsheets

Regime shifts are generally defined as the point of ‘abrupt’ change in the state of a system. However, a seemingly abrupt transition can be the product of a system reorganization that has been ongoing much longer than is evident in statistical analysis of a single component of the system. Using both univariate and multivariate statistical methods, we tested a long-term high-resolution paleoecological dataset with a known change in species assemblage for a regime shift. Analysis of this dataset with Fisher Information and multivariate time series modeling showed that there was a∼2000 year period of instability prior to the regime shift. This period of instability and the subsequent regime shift coincide with regional climate change, indicating that the system is undergoing extrinsic forcing. Paleoecological records offer a unique opportunity to test tools for the detection of thresholds and stable-states, and thus to examine the long-term stability of ecosystems over periods of multiple millennia. This manuscript explores various methods of assessing the transition between alternative states in an ecological system described by a long-term high-resolution paleoecological dataset.

Fine grained event processing on HPCs with the ATLAS Yoda system

NASA Astrophysics Data System (ADS)

Calafiura, Paolo; De, Kaushik; Guan, Wen; Maeno, Tadashi; Nilsson, Paul; Oleynik, Danila; Panitkin, Sergey; Tsulaia, Vakhtang; Van Gemmeren, Peter; Wenaus, Torre

2015-12-01

High performance computing facilities present unique challenges and opportunities for HEP event processing. The massive scale of many HPC systems means that fractionally small utilization can yield large returns in processing throughput. Parallel applications which can dynamically and efficiently fill any scheduling opportunities the resource presents benefit both the facility (maximal utilization) and the (compute-limited) science. The ATLAS Yoda system provides this capability to HEP-like event processing applications by implementing event-level processing in an MPI-based master-client model that integrates seamlessly with the more broadly scoped ATLAS Event Service. Fine grained, event level work assignments are intelligently dispatched to parallel workers to sustain full utilization on all cores, with outputs streamed off to destination object stores in near real time with similarly fine granularity, such that processing can proceed until termination with full utilization. The system offers the efficiency and scheduling flexibility of preemption without requiring the application actually support or employ check-pointing. We will present the new Yoda system, its motivations, architecture, implementation, and applications in ATLAS data processing at several US HPC centers.

The CHARA array adaptive optics I: common-path optical and mechanical design, and preliminary on-sky results

NASA Astrophysics Data System (ADS)

Che, Xiao; Sturmann, Laszlo; Monnier, John D.; ten Brummelaar, Theo A.; Sturmann, Judit; Ridgway, Stephen T.; Ireland, Michael J.; Turner, Nils H.; McAlister, Harold A.

2014-07-01

The CHARA array is an optical interferometer with six 1-meter diameter telescopes, providing baselines from 33 to 331 meters. With sub-milliarcsecond angular resolution, its versatile visible and near infrared combiners offer a unique angle of studying nearby stellar systems by spatially resolving their detailed structures. To improve the sensitivity and scientific throughput, the CHARA array was funded by NSF-ATI in 2011 to install adaptive optics (AO) systems on all six telescopes. The initial grant covers Phase I of the AO systems, which includes on-telescope Wavefront Sensors (WFS) and non-common-path (NCP) error correction. Meanwhile we are seeking funding for Phase II which will add large Deformable Mirrors on telescopes to close the full AO loop. The corrections of NCP error and static aberrations in the optical system beyond the WFS are described in the second paper of this series. This paper describes the design of the common-path optical system and the on-telescope WFS, and shows the on-sky commissioning results.

Administrative skills for academy physicians.

PubMed

Aluise, J J; Schmitz, C C; Bland, C J; McArtor, R E

To function effectively within the multifaceted environment of the academic medical center, academic physicians need to heighten their understanding of the economics of the health care system, and further develop their leadership and managerial skills. A literature base on organizational development and management education is now available, which addresses the unique nature of the professional organization, including academic medical centers. This article describes an administration development curriculum for academic physicians. Competency statements, instructional strategies, and references provide health care educators with a model for developing administrative skills programs for academic physicians and other health care professionals. The continuing success of the academic medical center as a responsive health care system may depend on the degree to which academic physicians and their colleagues in other fields gain sophistication in self-management and organizational administration. Health care educators can apply the competencies and instructional strategies offered in this article to administrative development programs for physicians and other health professionals in their institutions.

Low-frequency 1/f noise in graphene devices

NASA Astrophysics Data System (ADS)

Balandin, Alexander A.

2013-08-01

Low-frequency noise with a spectral density that depends inversely on frequency has been observed in a wide variety of systems including current fluctuations in resistors, intensity fluctuations in music and signals in human cognition. In electronics, the phenomenon, which is known as 1/f noise, flicker noise or excess noise, hampers the operation of numerous devices and circuits, and can be a significant impediment to the development of practical applications from new materials. Graphene offers unique opportunities for studying 1/f noise because of its two-dimensional structure and widely tunable two-dimensional carrier concentration. The creation of practical graphene-based devices will also depend on our ability to understand and control the low-frequency noise in this material system. Here, the characteristic features of 1/f noise in graphene and few-layer graphene are reviewed, and the implications of such noise for the development of graphene-based electronics including high-frequency devices and sensors are examined.

A Global Geographic Information System Data Base of Storm Occurrences and Other Climatic Phenomena Affecting Coastal Zones (1991) (NDP-035)

DOE Data Explorer

Birdwell, Kevub R. [Murray State University, Kentucky; Daniels, Richard C.

2012-01-01

This NDP is unique in that it represents CDIAC's first offering of ARC/INFOTM export data files and equivalent flat ASCII data files that may be used by raster or vector geographic information systems (GISs). The data set contains 61 variables, including information on tropical storms, hurricanes, super typhoons, extratropical cyclogeneses, polar lows, cyclonicity, influence of winds in monsoon regions, and sea-ice concentrations. Increased availability of source data has made it possible to extend the area of these data variables to regional or global coverages. All data variables except five are referenced to 1° × 1° or 5° × 5° grid cells of latitude and longitude. These data help meet the demand for new and improved climatologies of storm events and may be used in climate research studies, including the verification of general circulation models and the calculation of storm-recurrence intervals.

Using exosomes, naturally-equipped nanocarriers, for drug delivery.

PubMed

Batrakova, Elena V; Kim, Myung Soo

2015-12-10

Exosomes offer distinct advantages that uniquely position them as highly effective drug carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes are known to specialize in cell-cell communications and provide an exclusive approach for the delivery of various therapeutic agents to target cells. In addition, exosomes can be amended through their parental cells to express a targeting moiety on their surface, or supplemented with desired biological activity. Development and validation of exosome-based drug delivery systems are the focus of this review. Different techniques of exosome isolation, characterization, drug loading, and applications in experimental disease models and clinic are discussed. Exosome-based drug formulations may be applied to a wide variety of disorders such as cancer, various infectious, cardiovascular, and neurodegenerative disorders. Overall, exosomes combine benefits of both synthetic nanocarriers and cell-mediated drug delivery systems while avoiding their limitations. Published by Elsevier B.V.

Neural Systems Approaches to Understanding Major Depressive Disorder: An Intrinsic Functional Organization Perspective

PubMed Central

Hamilton, J. Paul; Chen, Michael C.; Gotlib, Ian H.

2012-01-01

Recent research detailing the intrinsic functional organization of the brain provides a unique and useful framework to gain a better understanding of the neural bases of Major Depressive Disorder (MDD). In this review, we first present a brief history of neuroimaging research that has increased our understanding of the functional macro-architecture of the brain. From this macro-architectural perspective, we examine the extant body of functional neuroimaging research assessing MDD with a specific emphasis on the contributions of default-mode, executive, and salience networks in this debilitating disorder. Next, we describe recent investigations conducted in our laboratory in which we explicitly adopt a neural-systems perspective in examining the relations among these networks in MDD. Finally, we offer directions for future research that we believe will facilitate the development of more detailed and integrative models of neural dysfunction in depression. PMID:23477309

Low-frequency 1/f noise in graphene devices.

PubMed

Balandin, Alexander A

2013-08-01

Low-frequency noise with a spectral density that depends inversely on frequency has been observed in a wide variety of systems including current fluctuations in resistors, intensity fluctuations in music and signals in human cognition. In electronics, the phenomenon, which is known as 1/f noise, flicker noise or excess noise, hampers the operation of numerous devices and circuits, and can be a significant impediment to the development of practical applications from new materials. Graphene offers unique opportunities for studying 1/f noise because of its two-dimensional structure and widely tunable two-dimensional carrier concentration. The creation of practical graphene-based devices will also depend on our ability to understand and control the low-frequency noise in this material system. Here, the characteristic features of 1/f noise in graphene and few-layer graphene are reviewed, and the implications of such noise for the development of graphene-based electronics including high-frequency devices and sensors are examined.

Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system

PubMed Central

Aryal, Muna; Arvanitis, Costas D.; Alexander, Phillip M.; McDannold, Nathan

2014-01-01

The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Different methods have been used to bypass the BBB, but they have limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete targets. This review provides insight on the current status of this unique drug delivery technique, experience in preclinical models, and potential for clinical translation. If translated to humans, this method would offer a flexible means to target therapeutics to desired points or volumes in the brain, and enable the whole arsenal of drugs in the CNS that are currently prevented by the BBB. PMID:24462453

Three-dimensional graphdiyne as a topological nodal-line semimetal

NASA Astrophysics Data System (ADS)

Nomura, Takafumi; Habe, Tetsuro; Sakamoto, Ryota; Koshino, Mikito

2018-05-01

We study the electronic band structure of three-dimensional ABC-stacked (rhombohedral) graphdiyne, which is a new planar carbon allotrope recently fabricated. Using first-principles calculation, we show that the system is a nodal-line semimetal, in which the conduction band and valence band cross at a closed ring in the momentum space. We derive the minimum tight-binding model and the low-energy effective Hamiltonian in a 4 ×4 matrix form. The nodal line is protected by a nontrivial winding number, and it ensures the existence of the topological surface state in a finite-thickness slab. The Fermi surface of the doped system exhibits a peculiar, self-intersecting hourglass structure, which is quite different from the torus or pipe shape in the previously proposed nodal semimetals. Despite its simple configuration, three-dimensional graphdiyne offers unique electronic properties distinct from any other carbon allotropes.

E-health in graduate and postgraduate medical education: illusions, expectations and reality.

PubMed

Bari, Ferenc; Forczek, Erzsébet; Hantos, Zoltán

2011-01-01

With the overall growth of informatics, the medical education system should also provide programs at both graduate and post-graduate levels. While there is a wide consensus as to the importance of this urgent need, several factors slow down the construction and operation of effective education programs in medical and nursing schools. The increasing need for better and more comprehensive training in informatics is strongly limited by several factors including undefined output skills, tight time frame etc. An efficient development of partnerships within the health care system assumes that all professionals involved must possess strong informatics and interpersonal knowledge, and skills reaching beyond their own individual fields. There is an emerging need to define the basic skills and knowledge for each level of the health care education. Trans-border cooperation offers a unique opportunity for the establishment of common criteria for basic skills and knowledge, via joint discussions, collaborative thinking and concerted action.

Diffractive optics technology and the NASA Geostationary Earth Observatory (GEO)

NASA Technical Reports Server (NTRS)

Morris, G. Michael; Michaels, Robert L.; Faklis, Dean

1992-01-01

Diffractive (or binary) optics offers unique capabilities for the development of large-aperture, high-performance, light-weight optical systems. The Geostationary Earth Observatory (GEO) will consist of a variety of instruments to monitor the environmental conditions of the earth and its atmosphere. The aim of this investigation is to analyze the design of the GEO instrument that is being proposed and to identify the areas in which diffractive (or binary) optics technology can make a significant impact in GEO sensor design. Several potential applications where diffractive optics may indeed serve as a key technology for improving the performance and reducing the weight and cost of the GEO sensors have been identified. Applications include the use of diffractive/refractive hybrid lenses for aft-optic imagers, diffractive telescopes for narrowband imaging, subwavelength structured surfaces for anti-reflection and polarization control, and aberration compensation for reflective imaging systems and grating spectrometers.

Protein Crystal Growth

NASA Technical Reports Server (NTRS)

2003-01-01

In order to rapidly and efficiently grow crystals, tools were needed to automatically identify and analyze the growing process of protein crystals. To meet this need, Diversified Scientific, Inc. (DSI), with the support of a Small Business Innovation Research (SBIR) contract from NASA s Marshall Space Flight Center, developed CrystalScore(trademark), the first automated image acquisition, analysis, and archiving system designed specifically for the macromolecular crystal growing community. It offers automated hardware control, image and data archiving, image processing, a searchable database, and surface plotting of experimental data. CrystalScore is currently being used by numerous pharmaceutical companies and academic and nonprofit research centers. DSI, located in Birmingham, Alabama, was awarded the patent Method for acquiring, storing, and analyzing crystal images on March 4, 2003. Another DSI product made possible by Marshall SBIR funding is VaporPro(trademark), a unique, comprehensive system that allows for the automated control of vapor diffusion for crystallization experiments.

Health-promoting prisons: theory to practice.

PubMed

Baybutt, Michelle; Chemlal, Khadoudja

2016-03-01

As a setting, prisons offer a unique opportunity to invest in the health of disadvantaged and marginalised populations and address health inequalities and social exclusion - thereby achieving sustainable improvements in well-being for offenders and their families and in turn, helping to reduce rates of re-offending. This article draws on English and French experiences and doctoral research to advocate a shift from a pathogenic model towards a salutogenic model of health as a helpful way to address inequalities and thus, by promoting joined-up working across justice and wider systems, impact positively beyond 'health' for the effective resettlement of prisoners. The paper utilises examples from horticulture to further argue the powerful role of nature in the prison setting in mediating aspects of culture particularly relating to processes of socialisation. Critical success lies in bridging across systems and a commitment to joined-up working at all levels across and beyond prison. © The Author(s) 2015.

Gels and gel-derived glasses in the Na2O-B2O3-SiO2 system. [containerless melting in space

NASA Technical Reports Server (NTRS)

Mukherjee, S. P.

1982-01-01

The containerless melting of high-purity multicomponent homogeneous gels and gel-monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the Na2O-B2O3-SiO2 system are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures were found to be significantly different. IR absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel-monoliths to transparent 'glass' without melting are described.

Gels and gel-derived glasses in the system Na2O-B2O3-SiO2

NASA Technical Reports Server (NTRS)

Mukherjee, S. P.

1983-01-01

The containerless melting of high-purity multicomponent homogeneous gels and gel monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the system Na2O-B2O3-SiO2 are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures was found to be significantly different. Infrared absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel monoliths to transparent 'glass' without melting are described.

Potential utilization of the NASA/George C. Marshall Space Flight Center in earthquake engineering research

NASA Technical Reports Server (NTRS)

Scholl, R. E. (Editor)

1979-01-01

Earthquake engineering research capabilities of the National Aeronautics and Space Administration (NASA) facilities at George C. Marshall Space Flight Center (MSFC), Alabama, were evaluated. The results indicate that the NASA/MSFC facilities and supporting capabilities offer unique opportunities for conducting earthquake engineering research. Specific features that are particularly attractive for large scale static and dynamic testing of natural and man-made structures include the following: large physical dimensions of buildings and test bays; high loading capacity; wide range and large number of test equipment and instrumentation devices; multichannel data acquisition and processing systems; technical expertise for conducting large-scale static and dynamic testing; sophisticated techniques for systems dynamics analysis, simulation, and control; and capability for managing large-size and technologically complex programs. Potential uses of the facilities for near and long term test programs to supplement current earthquake research activities are suggested.

The evolution of school nursing data indicators in Massachusetts: recommendations for a national data set.

PubMed

Gapinski, Mary Ann; Sheetz, Anne H

2014-10-01

The National Association of School Nurses' research priorities include the recommendation that data reliability, quality, and availability be addressed to advance research in child and school health. However, identifying a national school nursing data set has remained a challenge for school nurses, school nursing leaders, school nurse professional organizations, and state school nurse consultants. While there is much agreement that school nursing data (with associated data integrity) is an incredibly powerful tool for multiple uses, the content of a national data set must be developed. In 1993, recognizing the unique power of data, Massachusetts began addressing the need for consistent school nurse data collection. With more than 20 years' experience--and much experimentation, pilot testing, and system modification--Massachusetts is now ready to share its data collection system and certain key indicators with other states, thus offering a beginning foundation for a national school nursing data set. © The Author(s) 2014.

Systems modeling and simulation applications for critical care medicine

PubMed Central

2012-01-01

Critical care delivery is a complex, expensive, error prone, medical specialty and remains the focal point of major improvement efforts in healthcare delivery. Various modeling and simulation techniques offer unique opportunities to better understand the interactions between clinical physiology and care delivery. The novel insights gained from the systems perspective can then be used to develop and test new treatment strategies and make critical care delivery more efficient and effective. However, modeling and simulation applications in critical care remain underutilized. This article provides an overview of major computer-based simulation techniques as applied to critical care medicine. We provide three application examples of different simulation techniques, including a) pathophysiological model of acute lung injury, b) process modeling of critical care delivery, and c) an agent-based model to study interaction between pathophysiology and healthcare delivery. Finally, we identify certain challenges to, and opportunities for, future research in the area. PMID:22703718

Bistatic LIDAR experiment proposed for the shuttle/tethered satellite system missions

NASA Technical Reports Server (NTRS)

Mccomas, D. J.; Spense, H. E.; Karl, R. R.; Horak, H. G.; Wilkerson, T. D.

1986-01-01

A new experiment concept has been proposed for the shuttle/tethered satellite system missions, which can provide high resolution, global density mappings of certain ionospheric species. The technique utilizes bistatic LIDAR to take advantage of the unique dual platform configuration offered by these missions. A tuned, shuttle-based laser is used to excite a column of the atmosphere adjacent to the tethered satellite, while triangulating photometic detectors on the satellite are employed to measure the fluorescence from sections of the column. The fluorescent intensity at the detectors is increased about six decades over both ground-based and monostatic shuttle-based LIDAR sounding of the same region. In addition, the orbital motion of the Shuttle provides for quasi-global mapping unattainable with ground-based observations. Since this technique provides such vastly improved resolution on a synoptic scale, many important middle atmospheric studies, heretofore untenable, may soon be addressed.

Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned spaceflight.

PubMed

Wang, Linjie; Li, Zhili; Tan, Cheng; Liu, Shujuan; Zhang, Jianfeng; He, Siyang; Zou, Peng; Liu, Weibo; Li, Yinghui

2018-04-25

The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness.

Balloon-borne photoionization mass spectrometer for measurement of stratospheric gases

NASA Technical Reports Server (NTRS)

Aikin, A. C.; Maier, E. J. R.

1978-01-01

A balloon-borne photoionization mass spectrometer used to measure stratospheric trace gases is described. Ions are created with photons from high-intensity krypton discharge lamps and a quadrupole mass analyzer is employed for ion identification. Differential pumping is achieved with liquid helium cryopumping. To insure measurement of unperturbed stratospheric air, the entire system is contained in a sealed gondola and the atmospheric sample is taken some distance away during descent. The photoionization technique allows the detection of a low ionization potential constituent, such as nitric oxide, at less than a part in one billion in the presence of the major atmospheric gases and their isotopes. Operation of the mass spectrometer system was demonstrated during a daytime flight from Palestine, Texas on 26 April 1977. The sensitivity achieved and the unique selectivity afforded by this technique offer a capability for trace constituent measurement not possible with the more conventional electron impact ionization approach.

Brush Seals for Improved Steam Turbine Performance

NASA Technical Reports Server (NTRS)

Turnquist, Norman; Chupp, Ray; Baily, Fred; Burnett, Mark; Rivas, Flor; Bowsher, Aaron; Crudgington, Peter

2006-01-01

GE Energy has retrofitted brush seals into more than 19 operating steam turbines. Brush seals offer superior leakage control compared to labyrinth seals, owing to their compliant nature and ability to maintain very tight clearances to the rotating shaft. Seal designs have been established for steam turbines ranging in size from 12 MW to over 1200 MW, including fossil, nuclear, combined-cycle and industrial applications. Steam turbines present unique design challenges that must be addressed to ensure that the potential performance benefits of brush seals are realized. Brush seals can have important effects on the overall turbine system that must be taken into account to assure reliable operation. Subscale rig tests are instrumental to understanding seal behavior under simulated steam-turbine operating conditions, prior to installing brush seals in the field. This presentation discusses the technical challenges of designing brush seals for steam turbines; subscale testing; performance benefits of brush seals; overall system effects; and field applications.

Coparental Affect, Children's Emotion Dysregulation, and Parent and Child Depressive Symptoms.

PubMed

Thomassin, Kristel; Suveg, Cynthia; Davis, Molly; Lavner, Justin A; Beach, Steven R H

2017-03-01

Children's emotion dysregulation and depressive symptoms are known to be affected by a range of individual (parent, child) and systemic (parent-child, marital, and family) characteristics. The current study builds on this literature by examining the unique role of coparental affect in children's emotion dysregulation, and whether this association mediates the link between parent and child depressive symptoms. Participants were 51 mother-father-child triads with children aged 7 to 12 (M age = 9.24 years). Triads discussed a time when the child felt sad and a time when the child felt happy. Maternal and paternal displays of positive affect were coded, and sequential analyses examined the extent to which parents were congruent in their displays of positive affect during the emotion discussions. Results indicated that interparental positive affect congruity (IPAC) during the sadness discussion, but not the happiness discussion, uniquely predicted parent-reported child emotion dysregulation, above and beyond the contributions of child negative affect and parental punitive reactions. The degree of IPAC during the sadness discussion and child emotion dysregulation mediated the association between maternal, but not paternal, depressive symptoms and child depressive symptoms. Findings highlight the unique role of coparental affect in the socialization of sadness in youth and offer initial support for low levels of IPAC as a risk factor for the transmission of depressive symptoms in youth. © 2015 Family Process Institute.

Climate resiliency: A unique multi-hazard mitigation approach.

PubMed

Baja, Kristin

2016-01-01

Baltimore's unique combination of shocks and stresses cuts across social, economic and environmental factors. Like many other post-industrial cities, over the past several decades, Baltimore has experienced a decline in its population -- resulting in a lower tax base. These trends have had deleterious effects on the city's ability to attend to much needed infrastructure improvements and human and social services. In addition to considerable social and economic issues, the city has begun to experience negative impacts due to climate change. The compounding nature of these trends has put Baltimore, like other post-industrial cities, in the position of having to do more with fewer available resources. Rather than wait for disaster to strike, Baltimore took a proactive approach to planning for shocks and stresses by determining unique ways to pre-emptively plan for and adapt to effects from climate change and incorporating these into the City's All Hazard Mitigation Plan. Since adopting the plan in 2013, Baltimore has been moving forward with various projects aimed at improving systems, enhancing adaptive capacity and building a more resilient and sustainable city. This paper describes the basis for the city's approach and offers a portrait of its efforts in order to broaden foundational knowledge of the emerging ways that cities are recasting the role of planning in light of unprecedented circumstances that demand complex solutions that draw on few resources.

Simple algorithm for improved security in the FDDI protocol

NASA Astrophysics Data System (ADS)

Lundy, G. M.; Jones, Benjamin

1993-02-01

We propose a modification to the Fiber Distributed Data Interface (FDDI) protocol based on a simple algorithm which will improve confidential communication capability. This proposed modification provides a simple and reliable system which exploits some of the inherent security properties in a fiber optic ring network. This method differs from conventional methods in that end to end encryption can be facilitated at the media access control sublayer of the data link layer in the OSI network model. Our method is based on a variation of the bit stream cipher method. The transmitting station takes the intended confidential message and uses a simple modulo two addition operation against an initialization vector. The encrypted message is virtually unbreakable without the initialization vector. None of the stations on the ring will have access to both the encrypted message and the initialization vector except the transmitting and receiving stations. The generation of the initialization vector is unique for each confidential transmission and thus provides a unique approach to the key distribution problem. The FDDI protocol is of particular interest to the military in terms of LAN/MAN implementations. Both the Army and the Navy are considering the standard as the basis for future network systems. A simple and reliable security mechanism with the potential to support realtime communications is a necessary consideration in the implementation of these systems. The proposed method offers several advantages over traditional methods in terms of speed, reliability, and standardization.

A tale of two neglected systems—structure and function of the thin- and thick-walled sieve tubes in monocotyledonous leaves

PubMed Central

Botha, C. E. J.

2013-01-01

There is a large body of information relating to the ontogeny, development and the vasculature of eudicotyledonous leaves. However, there is less information available concerning the vascular anatomy of monocotyledonous leaves. This is surprising, given that there are two uniquely different phloem systems present in large groups such as grasses and sedges. Monocotyledonous leaves contain marginal, large, intermediate, and small longitudinal veins that are interconnected by numerous transverse veins. The longitudinal veins contain two metaphloem sieve tube types, which, based upon their ontogeny and position within the phloem, are termed early (thin-walled) and late (thick-walled) sieve tubes. Early metaphloem comprises sieve tubes, companion cells and vascular parenchyma (VP) cells, whilst the late metaphloem, contains thick-walled sieve tubes (TSTs) that lack companion cells. TSTs are generally adjacent to, or no more than one cell removed from the metaxylem. Unlike thin-walled sieve tube (ST) -companion cell complexes, TSTs are connected to parenchyma by pore-plasmodesma units and are generally symplasmically isolated from the STs. This paper addresses key structural and functional differences between thin- and thick-walled sieve tubes and explores the unique advantages of alternate transport strategies that this 5–7 million years old dual system may offer. It would seem that these two systems may enhance, add to, or play a significant role in increasing the efficiency of solute retrieval as well as of assimilate transfer. PMID:23964280

A Hybrid Neuro-Fuzzy Model For Integrating Large Earth-Science Datasets

NASA Astrophysics Data System (ADS)

Porwal, A.; Carranza, J.; Hale, M.

2004-12-01

A GIS-based hybrid neuro-fuzzy approach to integration of large earth-science datasets for mineral prospectivity mapping is described. It implements a Takagi-Sugeno type fuzzy inference system in the framework of a four-layered feed-forward adaptive neural network. Each unique combination of the datasets is considered a feature vector whose components are derived by knowledge-based ordinal encoding of the constituent datasets. A subset of feature vectors with a known output target vector (i.e., unique conditions known to be associated with either a mineralized or a barren location) is used for the training of an adaptive neuro-fuzzy inference system. Training involves iterative adjustment of parameters of the adaptive neuro-fuzzy inference system using a hybrid learning procedure for mapping each training vector to its output target vector with minimum sum of squared error. The trained adaptive neuro-fuzzy inference system is used to process all feature vectors. The output for each feature vector is a value that indicates the extent to which a feature vector belongs to the mineralized class or the barren class. These values are used to generate a prospectivity map. The procedure is demonstrated by an application to regional-scale base metal prospectivity mapping in a study area located in the Aravalli metallogenic province (western India). A comparison of the hybrid neuro-fuzzy approach with pure knowledge-driven fuzzy and pure data-driven neural network approaches indicates that the former offers a superior method for integrating large earth-science datasets for predictive spatial mathematical modelling.

Autonomous undulatory serpentine locomotion utilizing body dynamics of a fluidic soft robot.

PubMed

Onal, Cagdas D; Rus, Daniela

2013-06-01

Soft robotics offers the unique promise of creating inherently safe and adaptive systems. These systems bring man-made machines closer to the natural capabilities of biological systems. An important requirement to enable self-contained soft mobile robots is an on-board power source. In this paper, we present an approach to create a bio-inspired soft robotic snake that can undulate in a similar way to its biological counterpart using pressure for actuation power, without human intervention. With this approach, we develop an autonomous soft snake robot with on-board actuation, power, computation and control capabilities. The robot consists of four bidirectional fluidic elastomer actuators in series to create a traveling curvature wave from head to tail along its body. Passive wheels between segments generate the necessary frictional anisotropy for forward locomotion. It takes 14 h to build the soft robotic snake, which can attain an average locomotion speed of 19 mm s(-1).

Functional connectivity and dynamics of cortical-thalamic networks co-cultured in a dual compartment device

NASA Astrophysics Data System (ADS)

Kanagasabapathi, Thirukumaran T.; Massobrio, Paolo; Barone, Rocco Andrea; Tedesco, Mariateresa; Martinoia, Sergio; Wadman, Wytse J.; Decré, Michel M. J.

2012-06-01

Co-cultures containing dissociated cortical and thalamic cells may provide a unique model for understanding the pathophysiology in the respective neuronal sub-circuitry. In addition, developing an in vitro dissociated co-culture model offers the possibility of studying the system without influence from other neuronal sub-populations. Here we demonstrate a dual compartment system coupled to microelectrode arrays (MEAs) for co-culturing and recording spontaneous activities from neuronal sub-populations. Propagation of electrical activities between cortical and thalamic regions and their interdependence in connectivity is verified by means of a cross-correlation algorithm. We found that burst events originate in the cortical region and drive the entire cortical-thalamic network bursting behavior while mutually weak thalamic connections play a relevant role in sustaining longer burst events in cortical cells. To support these experimental findings, a neuronal network model was developed and used to investigate the interplay between network dynamics and connectivity in the cortical-thalamic system.

Boronate-Based Fluorescent Probes: Imaging Hydrogen Peroxide in Living Systems

PubMed Central

Lin, Vivian S.; Dickinson, Bryan C.; Chang, Christopher J.

2014-01-01

Hydrogen peroxide, a reactive oxygen species with unique chemical properties, is produced endogenously in living systems as a destructive oxidant to ward off pathogens or as a finely tuned second messenger in dynamic cellular signaling pathways. In order to understand the complex roles that hydrogen peroxide can play in biological systems, new tools to monitor hydrogen peroxide in its native settings, with high selectivity and sensitivity, are needed. Knowledge of organic synthetic reactivity provides the foundation for the molecular design of selective, functional hydrogen peroxide probes. A palette of fluorescent and luminescent probes that react chemoselectively with hydrogen peroxide has been developed, utilizing a boronate oxidation trigger. These indicators offer a variety of colors and in cellulo characteristics and have been used to examine hydrogen peroxide in a number of experimental setups, including in vitro fluorometry, confocal fluorescence microscopy, and flow cytometry. In this chapter, we provide an overview of the chemical features of these probes and information on their behavior to help researchers select the optimal probe and application. PMID:23791092

High bulk modulus of ionic liquid and effects on performance of hydraulic system.

PubMed

Kambic, Milan; Kalb, Roland; Tasner, Tadej; Lovrec, Darko

2014-01-01

Over recent years ionic liquids have gained in importance, causing a growing number of scientists and engineers to investigate possible applications for these liquids because of their unique physical and chemical properties. Their outstanding advantages such as nonflammable liquid within a broad liquid range, high thermal, mechanical, and chemical stabilities, low solubility for gases, attractive tribological properties (lubrication), and very low compressibility, and so forth, make them more interesting for applications in mechanical engineering, offering great potential for new innovative processes, and also as a novel hydraulic fluid. This paper focuses on the outstanding compressibility properties of ionic liquid EMIM-EtSO4, a very important physical chemically property when IL is used as a hydraulic fluid. This very low compressibility (respectively, very high Bulk modulus), compared to the classical hydraulic mineral oils or the non-flammable HFDU type of hydraulic fluids, opens up new possibilities regarding its usage within hydraulic systems with increased dynamics, respectively, systems' dynamic responses.

Trigger learning and ECG parameter customization for remote cardiac clinical care information system.

PubMed

Bashir, Mohamed Ezzeldin A; Lee, Dong Gyu; Li, Meijing; Bae, Jang-Whan; Shon, Ho Sun; Cho, Myung Chan; Ryu, Keun Ho

2012-07-01

Coronary heart disease is being identified as the largest single cause of death along the world. The aim of a cardiac clinical information system is to achieve the best possible diagnosis of cardiac arrhythmias by electronic data processing. Cardiac information system that is designed to offer remote monitoring of patient who needed continues follow up is demanding. However, intra- and interpatient electrocardiogram (ECG) morphological descriptors are varying through the time as well as the computational limits pose significant challenges for practical implementations. The former requires that the classification model be adjusted continuously, and the latter requires a reduction in the number and types of ECG features, and thus, the computational burden, necessary to classify different arrhythmias. We propose the use of adaptive learning to automatically train the classifier on up-to-date ECG data, and employ adaptive feature selection to define unique feature subsets pertinent to different types of arrhythmia. Experimental results show that this hybrid technique outperforms conventional approaches and is, therefore, a promising new intelligent diagnostic tool.

Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit.

PubMed

Ruf, S; Hermann, M; Berger, I J; Carrer, H; Bock, R

2001-09-01

Transgenic chloroplasts offer unique advantages in plant biotechnology, including high-level foreign protein expression, absence of epigenetic effects, and gene containment due to the lack of transgene transmission through pollen. However, broad application of plastid genome engineering in biotechnology has been largely hampered by both the lack of chloroplast transformation systems for major crop plants and the usually low plastid gene expression levels in nongreen tissues such as fruits, tubers, and other storage organs. Here we describe the development of a plastid transformation system for tomato, Lycopersicon esculentum. This is the first report on the generation of fertile transplastomic plants in a food crop with an edible fruit. We show that chromoplasts in the tomato fruit express the transgene to approximately 50% of the expression levels in leaf chloroplasts. Given the generally very high foreign protein accumulation rates that can be achieved in transgenic chloroplasts (>40% of the total soluble protein), this system paves the way to efficient production of edible vaccines, pharmaceuticals, and antibodies in tomato.

A Novel Characterization of Amalgamated Networks in Natural Systems

PubMed Central

Barranca, Victor J.; Zhou, Douglas; Cai, David

2015-01-01

Densely-connected networks are prominent among natural systems, exhibiting structural characteristics often optimized for biological function. To reveal such features in highly-connected networks, we introduce a new network characterization determined by a decomposition of network-connectivity into low-rank and sparse components. Based on these components, we discover a new class of networks we define as amalgamated networks, which exhibit large functional groups and dense connectivity. Analyzing recent experimental findings on cerebral cortex, food-web, and gene regulatory networks, we establish the unique importance of amalgamated networks in fostering biologically advantageous properties, including rapid communication among nodes, structural stability under attacks, and separation of network activity into distinct functional modules. We further observe that our network characterization is scalable with network size and connectivity, thereby identifying robust features significant to diverse physical systems, which are typically undetectable by conventional characterizations of connectivity. We expect that studying the amalgamation properties of biological networks may offer new insights into understanding their structure-function relationships. PMID:26035066

Sampling bias in an international internet survey of diversion programs in the criminal justice system.

PubMed

Hartford, Kathleen; Carey, Robert; Mendonca, James

2007-03-01

Despite advances in the storage and retrieval of information within health care systems, health researchers conducting surveys for evaluations still face technical barriers that may lead to sampling bias. The authors describe their experience in administering a Web-based, international survey to English-speaking countries. Identifying the sample was a multistage effort involving (a) searching for published e-mail addresses, (b) conducting Web searches for publicly funded agencies, and (c) performing literature searches, personal contacts, and extensive Internet searches for individuals. After pretesting, the survey was converted into an electronic format accessible by multiple Web browsers. Sampling bias arose from (a) system incompatibility, which did not allow potential respondents to open the survey, (b) varying institutional gate-keeping policies that "recognized" the unsolicited survey as spam, (c) culturally unique program terminology, which confused some respondents, and (d) incomplete sampling frames. Solutions are offered to the first three problems, and the authors note that sampling bias remains a crucial problem.

Big power from walking

NASA Astrophysics Data System (ADS)

Illenberger, Patrin K.; Madawala, Udaya K.; Anderson, Iain A.

2016-04-01

Dielectric Elastomer Generators (DEG) offer an opportunity to capture the energy otherwise wasted from human motion. By integrating a DEG into the heel of standard footwear, it is possible to harness this energy to power portable devices. DEGs require substantial auxiliary systems which are commonly large, heavy and inefficient. A unique challenge for these low power generators is the combination of high voltage and low current. A void exists in the semiconductor market for devices that can meet these requirements. Until these become available, existing devices must be used in an innovative way to produce an effective DEG system. Existing systems such as the Bi-Directional Flyback (BDFB) and Self Priming Circuit (SPC) are an excellent example of this. The BDFB allows full charging and discharging of the DEG, improving power gained. The SPC allows fully passive voltage boosting, removing the priming source and simplifying the electronics. This paper outlines the drawbacks and benefits of active and passive electronic solutions for maximizing power from walking.

Wireless physiological monitoring and ocular tracking: 3D calibration in a fully-immersive virtual health care environment.

PubMed

Zhang, Lelin; Chi, Yu Mike; Edelstein, Eve; Schulze, Jurgen; Gramann, Klaus; Velasquez, Alvaro; Cauwenberghs, Gert; Macagno, Eduardo

2010-01-01

Wireless physiological/neurological monitoring in virtual reality (VR) offers a unique opportunity for unobtrusively quantifying human responses to precisely controlled and readily modulated VR representations of health care environments. Here we present such a wireless, light-weight head-mounted system for measuring electrooculogram (EOG) and electroencephalogram (EEG) activity in human subjects interacting with and navigating in the Calit2 StarCAVE, a five-sided immersive 3-D visualization VR environment. The system can be easily expanded to include other measurements, such as cardiac activity and galvanic skin responses. We demonstrate the capacity of the system to track focus of gaze in 3-D and report a novel calibration procedure for estimating eye movements from responses to the presentation of a set of dynamic visual cues in the StarCAVE. We discuss cyber and clinical applications that include a 3-D cursor for visual navigation in VR interactive environments, and the monitoring of neurological and ocular dysfunction in vision/attention disorders.

Human cell culture in a space bioreactor

NASA Technical Reports Server (NTRS)

Morrison, Dennis R.

1988-01-01

Microgravity offers new ways of handling fluids, gases, and growing mammalian cells in efficient suspension cultures. In 1976 bioreactor engineers designed a system using a cylindrical reactor vessel in which the cells and medium are slowly mixed. The reaction chamber is interchangeable and can be used for several types of cell cultures. NASA has methodically developed unique suspension type cell and recovery apparatus culture systems for bioprocess technology experiments and production of biological products in microgravity. The first Space Bioreactor was designed for microprocessor control, no gaseous headspace, circulation and resupply of culture medium, and slow mixing in very low shear regimes. Various ground based bioreactors are being used to test reactor vessel design, on-line sensors, effects of shear, nutrient supply, and waste removal from continuous culture of human cells attached to microcarriers. The small Bioreactor is being constructed for flight experiments in the Shuttle Middeck to verify systems operation under microgravity conditions and to measure the efficiencies of mass transport, gas transfer, oxygen consumption and control of low shear stress on cells.

Optomechanics in a Levitated Droplet of Superfluid Helium

NASA Astrophysics Data System (ADS)

Brown, Charles; Harris, Glen; Harris, Jack

2017-04-01

A critical issue common to all optomechanical systems is dissipative coupling to the environment, which limits the system's quantum coherence. Superfluid helium's extremely low optical and mechanical dissipation, as well as its high thermal conductivity and its ability cool itself via evaporation, makes the mostly uncharted territory of superfluid optomechanics an exciting avenue for exploring quantum effects in macroscopic objects. I will describe ongoing work that aims to exploit the unique properties of superfluid helium by constructing an optomechanical system consisting of a magnetically levitated droplet of superfluid helium., The optical whispering gallery modes (WGMs) of the droplet, as well as the mechanical oscillations of its surface, should offer exceptionally low dissipation, and should couple to each other via the usual optomechanical interactions. I will present recent progress towards this goal, and also discuss the background for this work, which includes prior demonstrations of magnetic levitation of superfluid helium, high finesse WGMs in liquid drops, and the self-cooling of helium drops in vacuum.

Efficient and stable transformation of Lactuca sativa L. cv. Cisco (lettuce) plastids.

PubMed

Kanamoto, Hirosuke; Yamashita, Atsushi; Asao, Hiroshi; Okumura, Satoru; Takase, Hisabumi; Hattori, Masahira; Yokota, Akiho; Tomizawa, Ken-Ichi

2006-04-01

Transgenic plastids offer unique advantages in plant biotechnology, including high-level foreign protein expression. However, broad application of plastid genome engineering in biotechnology has been largely hampered by the lack of plastid transformation systems for major crops. Here we describe the development of a plastid transformation system for lettuce, Lactuca sativa L. cv. Cisco. The transforming DNA carries a spectinomycin-resistance gene (aadA) under the control of lettuce chloroplast regulatory expression elements, flanked by two adjacent lettuce plastid genome sequences allowing its targeted insertion between the rbcL and accD genes. On average, we obtained 1 transplastomic lettuce plant per bombardment. We show that lettuce leaf chloroplasts can express transgene-encoded GFP to approximately 36% of the total soluble protein. All transplastomic T0 plants were fertile and the T1 progeny uniformly showed stability of the transgene in the chloroplast genome. This system will open up new possibilities for the efficient production of edible vaccines, pharmaceuticals, and antibodies in plants.