Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9/11 World Trade Center attacks.

PubMed

Rosen, Rebecca L; Levy-Carrick, Nomi; Reibman, Joan; Xu, Ning; Shao, Yongzhao; Liu, Mengling; Ferri, Lucia; Kazeros, Angeliki; Caplan-Shaw, Caralee E; Pradhan, Deepak R; Marmor, Michael; Galatzer-Levy, Isaac R

2017-06-01

Systemic inflammation has emerged as a promising marker and potential mechanism underlying post-traumatic stress disorder (PTSD). The relationship between posttraumatic stress pathology and systemic inflammation has not, however, been consistently replicated and is potentially confounded by comorbid illness or injury, common complications of trauma exposure. We analyzed a large naturalistic cohort sharing a discrete physical and mental health trauma from the destruction of the World Trade Center (WTC) towers on September 11, 2001 (n = 641). We evaluated the relationship between multiple physical and mental health related indices collected through routine evaluations at the WTC Environmental Health Center (WTC EHC), a treatment program for community members exposed to the disaster. C-Reactive Protein (CRP), a marker of systemic inflammation, was examined in relation to scores for PTSD, PTSD symptom clusters (re-experiencing, avoidance, negative cognitions/mood, arousal), depression and anxiety, while controlling for WTC exposures, lower respiratory symptoms, age, sex, BMI and smoking as potential risks or confounders. CRP was positively associated with PTSD severity (p < 0.001), trending toward association with depression (p = 0.06), but not with anxiety (p = 0.27). CRP was positively associated with re-experiencing (p < 0.001) and avoidance (p < 0.05) symptom clusters, and trended toward associations with negative cognitions/mood (p = 0.06) and arousal (p = 0.08). In this large study of the relationship between CRP and posttraumatic stress pathology, we demonstrated an association between systemic inflammation and stress pathology (PTSD; trending with depression), which remained after adjusting for potentially confounding variables. These results contribute to research findings suggesting a salient relationship between inflammation and posttraumatic stress pathology. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

The Level of Desirability of Information Technology Systems and Its Relation with Organizational Commitment

ERIC Educational Resources Information Center

Allammeh, Sayyed Mohsen; Shavaran, Hamidreza; Dabaghi, Azizollah; Arbabisarjou, Azizollah

2011-01-01

Purpose: This paper aims to define Information Technology (IT) desirability and determine IT relationship with organizational commitment. The existence of such a relationship between IT & organizational commitment can guide the organizational leaders to promote and to develop the IT potentials in order to improve the performance of employees,…

Photovoltaics as a terrestrial energy source. Volume 3: An overview

NASA Technical Reports Server (NTRS)

Smith, J. L.

1980-01-01

Photovoltaic (PV) systems were evaluated in terms of their potential for terrestrial application A comprehensive overview of important issues which bear on photovoltaic (PV) systems development is presented. Studies of PV system costs, the societal implications of PV system development, and strategies in PV research and development in relationship to current energy policies are summarized.

Maintenance of Austral Summertime Upper-Tropospheric Circulation over Tropical South America: The Bolivian High-Nordeste Low System.

NASA Astrophysics Data System (ADS)

Chen, Tsing-Chang; Weng, Shu-Ping; Schubert, Siegfried

1999-07-01

Using the NASA/GEOS reanalysis data for 1980-95, the austral-summer stationary eddies in the tropical-subtropical Southern Hemisphere are examined in two wave regimes: long and short wave (wave 1 and waves 2-6, respectively). The basic structure of the Bolivian high-Nordeste low (BH-NL) system is formed by a short-wave train across South America but modulated by the long-wave regime. The short-wave train exhibits a monsoonlike vertical phase reversal in the midtroposphere and a quarter-wave phase shift relative to the divergent circulation. As inferred from (a) the spatial relationship between the streamfunction and velocity potential and (b) the structure of the divergent circulation, the short-wave train forming the BH-NL system is maintained by South American local heating and remote African heating, while the long-wave regime is maintained by western tropical Pacific heating.The maintenance of the stationary waves in the two wave regimes is further illustrated by a simple diagnostic scheme that includes the velocity-potential maintenance equation (which links velocity potential and diabatic heating) and the streamfunction budget (which is the inverse Laplacian transform of the vorticity equation). Some simple relationships between streamfunction and velocity potential for both wave regimes are established to substantiate the links between diabatic heating and streamfunction; of particular interest is a Sverdrup balance in the short-wave regime. This simplified vorticity equation explains the vertical structure of the short-wave train associated with the BH-NL system and its spatial relationship with the divergent circulation.Based upon the diagnostic analysis of its maintenance a simple forced barotropic model is adopted to simulate the BH-NL system with idealized forcings, which imitates the real 200-mb divergence centers over South America, Africa, and the tropical Pacific. Numerical simulations demonstrate that the formation of the BH-NL system is affected not only by the African remote forcing, but also by the tropical Pacific forcing.

Interactive Relationships with Computers in Teaching Reading.

ERIC Educational Resources Information Center

Doublier, Rene M.

This study summarizes recent achievements in the expanding development of man/machine communications and reviews current technological hurdles associated with the development of artificial intelligence systems which can generate and recognize human speech patterns. With the development of such systems, one potential application would be the…

Invited Commentary: Explaining the Relationship Between Attending Worship Services and Mortality-A Brief Excursion Into the Contribution of Social Relationships in Religious Institutions.

PubMed

Krause, Neal

2017-04-01

In this issue of the Journal, VanderWeele et al. (Am J Epidemiol. 2017;000(00):000-000) report that more frequent attendance at worship services is associated with a lower mortality risk. However, the underlying processes that might explain this relationship were not discussed fully. A problem arises because the potentially beneficial association between attending worship services and mortality risk may be due to a number of different factors. At least part of the explanation may be found by turning to social relationships that arise in religious institutions. Within this context, there are potentially important benefits of providing social support to others. Support can be provided in several ways that involve potentially important health-related associations. In this commentary, I briefly examine the possible relationships between religious social support systems and other dimensions of congregational life and health. In-depth conceptual analyses are needed to move research in religious involvement and mortality to the next level. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The Third Rail of Family Systems: Sibling Relationships, Mental and Behavioral Health, and Preventive Intervention in Childhood and Adolescence

PubMed Central

Feinberg, Mark E.; Solmeyer, Anna R.; McHale, Susan M.

2011-01-01

Sibling relationships are an important context for development, but are often ignored in research and preventive interventions with youth and families. In childhood and adolescence siblings spend considerable time together, and siblings’ characteristics and sibling dynamics substantially influence developmental trajectories and outcomes. This paper reviews research on sibling relationships in childhood and adolescence, focusing on sibling dynamics as part of the family system and sibling influences on adjustment problems, including internalizing and externalizing behaviors and substance use. We present a theoretical model that describes three key pathways of sibling influence: one that extends through siblings’ experiences with peers and school, and two that operate largely through family relationships. We then describe the few existing preventive interventions that target sibling relationships and discuss the potential utility of integrating siblings into child and family programs. PMID:22105663

A case study for the integration of predictive mineral potential maps

NASA Astrophysics Data System (ADS)

Lee, Saro; Oh, Hyun-Joo; Heo, Chul-Ho; Park, Inhye

2014-09-01

This study aims to elaborate on the mineral potential maps using various models and verify the accuracy for the epithermal gold (Au) — silver (Ag) deposits in a Geographic Information System (GIS) environment assuming that all deposits shared a common genesis. The maps of potential Au and Ag deposits were produced by geological data in Taebaeksan mineralized area, Korea. The methodological framework consists of three main steps: 1) identification of spatial relationships 2) quantification of such relationships and 3) combination of multiple quantified relationships. A spatial database containing 46 Au-Ag deposits was constructed using GIS. The spatial association between training deposits and 26 related factors were identified and quantified by probabilistic and statistical modelling. The mineral potential maps were generated by integrating all factors using the overlay method and recombined afterwards using the likelihood ratio model. They were verified by comparison with test mineral deposit locations. The verification revealed that the combined mineral potential map had the greatest accuracy (83.97%), whereas it was 72.24%, 65.85%, 72.23% and 71.02% for the likelihood ratio, weight of evidence, logistic regression and artificial neural network models, respectively. The mineral potential map can provide useful information for the mineral resource development.

Performance evaluation of public hospital information systems by the information system success model.

PubMed

Cho, Kyoung Won; Bae, Sung-Kwon; Ryu, Ji-Hye; Kim, Kyeong Na; An, Chang-Ho; Chae, Young Moon

2015-01-01

This study was to evaluate the performance of the newly developed information system (IS) implemented on July 1, 2014 at three public hospitals in Korea. User satisfaction scores of twelve key performance indicators of six IS success factors based on the DeLone and McLean IS Success Model were utilized to evaluate IS performance before and after the newly developed system was introduced. All scores increased after system introduction except for the completeness of medical records and impact on the clinical environment. The relationships among six IS factors were also analyzed to identify the important factors influencing three IS success factors (Intention to Use, User Satisfaction, and Net Benefits). All relationships were significant except for the relationships among Service Quality, Intention to Use, and Net Benefits. The results suggest that hospitals should not only focus on systems and information quality; rather, they should also continuously improve service quality to improve user satisfaction and eventually reach full the potential of IS performance.

"Everything Has to Die One Day:" Children's Explorations of the Meanings of Death in Human-Animal-Nature Relationships

ERIC Educational Resources Information Center

Russell, Joshua

2017-01-01

Children's experiences of death are a potentially vital component of their developing sense of relatedness to non-human others and nature. Environmental education theory and practice would benefit from a broader understanding of how children view death and loss within ecological systems as well as within human-animal-nature relationships, but such…

Scaling dependence and synchronization of forced mercury beating heart systems

NASA Astrophysics Data System (ADS)

Biswas, Animesh; Das, Dibyendu; Parmananda, P.

2017-04-01

We perform experiments on a nonautonomous Mercury beating heart system, which is forced to pulsate using an external square wave potential. At suitable frequencies and volumes, the drop exhibits pulsation with polygonal shapes having n corners. We find the scaling dependence of the forcing frequency νn on the volume V of the drop and establish the relationship νn∝n/√{V } . It is shown that the geometrical shape of substrate is important for obtaining closer match to these scaling relationships. Furthermore, we study synchronization of two nonidentical drops driven by the same frequency and establish that synchrony happens when the relationship n2/n1=√{V2/V1 } is satisfied.

Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.

PubMed

Fraser, James A; Huang, Christopher L-H; Pedersen, Thomas H

2011-07-01

Activation of skeletal muscle fibers requires rapid sarcolemmal action potential (AP) conduction to ensure uniform excitation along the fiber length, as well as successful tubular excitation to initiate excitation-contraction coupling. In our companion paper in this issue, Pedersen et al. (2011. J. Gen. Physiol. doi:10.1085/jgp.201010510) quantify, for subthreshold stimuli, the influence upon both surface conduction velocity and tubular (t)-system excitation of the large changes in resting membrane conductance (G(M)) that occur during repetitive AP firing. The present work extends the analysis by developing a multi-compartment modification of the charge-difference model of Fraser and Huang to provide a quantitative description of the conduction velocity of actively propagated APs; the influence of voltage-gated ion channels within the t-system; the influence of t-system APs on ionic homeostasis within the t-system; the influence of t-system ion concentration changes on membrane potentials; and the influence of Phase I and Phase II G(M) changes on these relationships. Passive conduction properties of the novel model agreed with established linear circuit analysis and previous experimental results, while key simulations of AP firing were tested against focused experimental microelectrode measurements of membrane potential. This study thereby first quantified the effects of the t-system luminal resistance and voltage-gated Na(+) channel density on surface AP propagation and the resultant electrical response of the t-system. Second, it demonstrated the influence of G(M) changes during repetitive AP firing upon surface and t-system excitability. Third, it showed that significant K(+) accumulation occurs within the t-system during repetitive AP firing and produces a baseline depolarization of the surface membrane potential. Finally, it indicated that G(M) changes during repetitive AP firing significantly influence both t-system K(+) accumulation and its influence on the resting membrane potential. Thus, the present study emerges with a quantitative description of the changes in membrane potential, excitability, and t-system ionic homeostasis that occur during repetitive AP firing in skeletal muscle.

Capturing complexity in work disability research: application of system dynamics modeling methodology.

PubMed

Jetha, Arif; Pransky, Glenn; Hettinger, Lawrence J

2016-01-01

Work disability (WD) is characterized by variable and occasionally undesirable outcomes. The underlying determinants of WD outcomes include patterns of dynamic relationships among health, personal, organizational and regulatory factors that have been challenging to characterize, and inadequately represented by contemporary WD models. System dynamics modeling (SDM) methodology applies a sociotechnical systems thinking lens to view WD systems as comprising a range of influential factors linked by feedback relationships. SDM can potentially overcome limitations in contemporary WD models by uncovering causal feedback relationships, and conceptualizing dynamic system behaviors. It employs a collaborative and stakeholder-based model building methodology to create a visual depiction of the system as a whole. SDM can also enable researchers to run dynamic simulations to provide evidence of anticipated or unanticipated outcomes that could result from policy and programmatic intervention. SDM may advance rehabilitation research by providing greater insights into the structure and dynamics of WD systems while helping to understand inherent complexity. Challenges related to data availability, determining validity, and the extensive time and technical skill requirements for model building may limit SDM's use in the field and should be considered. Contemporary work disability (WD) models provide limited insight into complexity associated with WD processes. System dynamics modeling (SDM) has the potential to capture complexity through a stakeholder-based approach that generates a simulation model consisting of multiple feedback loops. SDM may enable WD researchers and practitioners to understand the structure and behavior of the WD system as a whole, and inform development of improved strategies to manage straightforward and complex WD cases.

A computerized test system for thermal-mechanical fatigue crack growth

NASA Technical Reports Server (NTRS)

Marchand, N.; Pelloux, R. M.

1986-01-01

A computerized testing system to measure fatigue crack growth under thermal-mechanical fatigue conditions is described. Built around a servohydraulic machine, the system is capable of a push-pull test under stress-controlled or strain-controlled conditions in the temperature range of 25 to 1050 C. Temperature and mechanical strain are independently controlled by the closed-loop system to simulate the complex inservice strain-temperature relationship. A d-c electrical potential method is used to measure crack growth rates. The correction procedure of the potential signal to take into account powerline and RF-induced noises and thermal changes is described. It is shown that the potential drop technique can be used for physical mechanism studies and for modelling crack tip processes.

Using clinical indicators to facilitate quality improvement via the accreditation process: an adaptive study into the control relationship.

PubMed

Chuang, Sheuwen; Howley, Peter P; Hancock, Stephen

2013-07-01

The aim of the study was to determine accreditation surveyors' and hospitals' use and perceived usefulness of clinical indicator reports and the potential to establish the control relationship between the accreditation and reporting systems. The control relationship refers to instructional directives, arising from appropriately designed methods and efforts towards using clinical indicators, which provide a directed moderating, balancing and best outcome for the connected systems. Web-based questionnaire survey. Australian Council on Healthcare Standards' (ACHS) accreditation and clinical indicator programmes. Seventy-three of 306 surveyors responded. Half used the reports always/most of the time. Five key messages were revealed: (i) report use was related to availability before on-site investigation; (ii) report use was associated with the use of non-ACHS reports; (iii) a clinical indicator set's perceived usefulness was associated with its reporting volume across hospitals; (iv) simpler measures and visual summaries in reports were rated the most useful; (v) reports were deemed to be suitable for the quality and safety objectives of the key groups of interested parties (hospitals' senior executive and management officers, clinicians, quality managers and surveyors). Implementing the control relationship between the reporting and accreditation systems is a promising expectation. Redesigning processes to ensure reports are available in pre-survey packages and refined education of surveyors and hospitals on how to better utilize the reports will support the relationship. Additional studies on the systems' theory-based model of the accreditation and reporting system are warranted to establish the control relationship, building integrated system-wide relationships with sustainable and improved outcomes.

Space station functional relationships analysis

NASA Technical Reports Server (NTRS)

Tullis, Thomas S.; Bied, Barbra R.

1988-01-01

A systems engineering process is developed to assist Space Station designers to understand the underlying operational system of the facility so that it can be physically arranged and configured to support crew productivity. The study analyzes the operational system proposed for the Space Station in terms of mission functions, crew activities, and functional relationships in order to develop a quantitative model for evaluation of interior layouts, configuration, and traffic analysis for any Station configuration. Development of the model involved identification of crew functions, required support equipment, criteria of assessing functional relationships, and tools for analyzing functional relationship matrices, as well as analyses of crew transition frequency, sequential dependencies, support equipment requirements, potential for noise interference, need for privacy, and overall compatability of functions. The model can be used for analyzing crew functions for the Initial Operating Capability of the Station and for detecting relationships among these functions. Note: This process (FRA) was used during Phase B design studies to test optional layouts of the Space Station habitat module. The process is now being automated as a computer model for use in layout testing of the Space Station laboratory modules during Phase C.

Higher Education, Employability and Competitiveness

ERIC Educational Resources Information Center

Pavlin, Samo; Svetlicic, Marjan

2012-01-01

This paper studies the relationship between competitiveness and higher education systems in Europe. It explores whether more competitive countries have developed more labour-market-oriented systems of higher education (HE) that thereby give their graduates greater short term employability potential. Based on and a large-scale survey among 45.000…

Using satellite fire detection to calibrate components of the fire weather index system in Malaysia and Indonesia.

PubMed

Dymond, Caren C; Field, Robert D; Roswintiarti, Orbita; Guswanto

2005-04-01

Vegetation fires have become an increasing problem in tropical environments as a consequence of socioeconomic pressures and subsequent land-use change. In response, fire management systems are being developed. This study set out to determine the relationships between two aspects of the fire problems in western Indonesia and Malaysia, and two components of the Canadian Forest Fire Weather Index System. The study resulted in a new method for calibrating components of fire danger rating systems based on satellite fire detection (hotspot) data. Once the climate was accounted for, a problematic number of fires were related to high levels of the Fine Fuel Moisture Code. The relationship between climate, Fine Fuel Moisture Code, and hotspot occurrence was used to calibrate Fire Occurrence Potential classes where low accounted for 3% of the fires from 1994 to 2000, moderate accounted for 25%, high 26%, and extreme 38%. Further problems arise when there are large clusters of fires burning that may consume valuable land or produce local smoke pollution. Once the climate was taken into account, the hotspot load (number and size of clusters of hotspots) was related to the Fire Weather Index. The relationship between climate, Fire Weather Index, and hotspot load was used to calibrate Fire Load Potential classes. Low Fire Load Potential conditions (75% of an average year) corresponded with 24% of the hotspot clusters, which had an average size of 30% of the largest cluster. In contrast, extreme Fire Load Potential conditions (1% of an average year) corresponded with 30% of the hotspot clusters, which had an average size of 58% of the maximum. Both Fire Occurrence Potential and Fire Load Potential calibrations were successfully validated with data from 2001. This study showed that when ground measurements are not available, fire statistics derived from satellite fire detection archives can be reliably used for calibration. More importantly, as a result of this work, Malaysia and Indonesia have two new sources of information to initiate fire prevention and suppression activities.

Perils, pitfalls, and benefits of a surgeon as a health system employee: the contracting process.

PubMed

Graebner, Nancy K

2011-06-01

One would be hard pressed today to find a general surgeon or subspecialty-trained general surgeon who has not been approached by a health system to discuss employment. The majority of physicians find these initial discussions with a hospital administrator daunting at best regardless of whether they are just finishing residency or fellowship training or have had many successful years of private practice under their belt. Just as real estate has the mantra of "location, location, location," I would suggest that physician employment by a health system should have the mantra of "relationship, relationship, relationship." The following tips provide guidance on how to better understand the potential perils, pitfalls, and benefits of specific content sections of a standard template employment agreement between a health system and a physician. Physicians should review, understand, and be ready to engage in dialogue with the hospital administrator before involving attorneys. My experience is that if the dialogue begins with the attorneys representing each party, the opportunity to fully develop a partnership relationship between the parties is either lost or at minimum severely delayed in its development.

[The immune system and the eye].

PubMed

Faber, Carsten; Nissen, Mogens Holst

2008-09-15

The special relationship between the eye and the immune system rests on a number of anatomical, physiological and immunological mechanisms. These mechanisms prevent the delicate structures of the eye from potentially damaging immunogenic inflammation while protecting against pathogens. Rather than inflammation, antigen induces a form of systemic and antigen-specific immunological tolerance. Owing to its systemic nature, this tolerance may be utilised to achieve successful treatment of immunological disorders.

Creating More Credible and Persuasive Recommender Systems: The Influence of Source Characteristics on Recommender System Evaluations

NASA Astrophysics Data System (ADS)

Yoo, Kyung-Hyan; Gretzel, Ulrike

Whether users are likely to accept the recommendations provided by a recommender system is of utmost importance to system designers and the marketers who implement them. By conceptualizing the advice seeking and giving relationship as a fundamentally social process, important avenues for understanding the persuasiveness of recommender systems open up. Specifically, research regarding the influence of source characteristics, which is abundant in the context of humanhuman relationships, can provide an important framework for identifying potential influence factors. This chapter reviews the existing literature on source characteristics in the context of human-human, human-computer, and human-recommender system interactions. It concludes that many social cues that have been identified as influential in other contexts have yet to be implemented and tested with respect to recommender systems. Implications for recommender system research and design are discussed.

Learning the Rules of the Game: Four Views of the Relation between Social Interaction and Syntax Acquisition. Technical Report No. 214.

ERIC Educational Resources Information Center

Shatz, Marilyn

Arguing that the vagueness with which the relationship between social interaction and language is often treated in the literature makes it difficult to explicate and evaluate different views of that relationship, this paper poses four questions designed to differentiate positions and to provide a system for organizing data potentially relevant to…

[The relationship between the State and workers' unions and its impacts in the union-based health coverage regime in Argentina: an historical and political analysis].

PubMed

De Fazio, Federico Leandro

2013-12-01

This paper aims at developing a political and historical reconstruction of the period spanning from the late nineteenth century to the present. In particular, this work investigates the relationship between the Argentine State and workers' unions and the impacts of that relationship in the establishment, consolidation and potential decline of the health coverage system administrated by unions, in Argentina called obras sociales. This work will also support the hypothesis that the financing obtained by union leaders through this health coverage system has been an efficient instrument for sustaining a centralized union model and has in some cases guaranteed the continued governance of both union leaders and different national governments.

The Properties of Terrestrial Laser System Intensity for Measuring Leaf Geometries: A Case Study with Conference Pear Trees (Pyrus Communis)

PubMed Central

Balduzzi, Mathilde A.F.; Van der Zande, Dimitry; Stuckens, Jan; Verstraeten, Willem W.; Coppin, Pol

2011-01-01

Light Detection and Ranging (LiDAR) technology can be a valuable tool for describing and quantifying vegetation structure. However, because of their size, extraction of leaf geometries remains complicated. In this study, the intensity data produced by the Terrestrial Laser System (TLS) FARO LS880 is corrected for the distance effect and its relationship with the angle of incidence between the laser beam and the surface of the leaf of a Conference Pear tree (Pyrus Commmunis) is established. The results demonstrate that with only intensity, this relationship has a potential for determining the angle of incidence with the leaves surface with a precision of ±5° for an angle of incidence smaller than 60°, whereas it is more variable for an angle of incidence larger than 60°. It appears that TLS beam footprint, leaf curvatures and leaf wrinkles have an impact on the relationship between intensity and angle of incidence, though, this analysis shows that the intensity of scanned leaves has a potential to eliminate ghost points and to improve their meshing. PMID:22319374

Transactive memory systems scale for couples: development and validation

PubMed Central

Hewitt, Lauren Y.; Roberts, Lynne D.

2015-01-01

People in romantic relationships can develop shared memory systems by pooling their cognitive resources, allowing each person access to more information but with less cognitive effort. Research examining such memory systems in romantic couples largely focuses on remembering word lists or performing lab-based tasks, but these types of activities do not capture the processes underlying couples’ transactive memory systems, and may not be representative of the ways in which romantic couples use their shared memory systems in everyday life. We adapted an existing measure of transactive memory systems for use with romantic couples (TMSS-C), and conducted an initial validation study. In total, 397 participants who each identified as being a member of a romantic relationship of at least 3 months duration completed the study. The data provided a good fit to the anticipated three-factor structure of the components of couples’ transactive memory systems (specialization, credibility and coordination), and there was reasonable evidence of both convergent and divergent validity, as well as strong evidence of test–retest reliability across a 2-week period. The TMSS-C provides a valuable tool that can quickly and easily capture the underlying components of romantic couples’ transactive memory systems. It has potential to help us better understand this intriguing feature of romantic relationships, and how shared memory systems might be associated with other important features of romantic relationships. PMID:25999873

Periodontitis and systemic lupus erythematosus.

PubMed

Sete, Manuela Rubim Camara; Figueredo, Carlos Marcelo da Silva; Sztajnbok, Flavio

2016-01-01

A large number of studies have shown a potential association between periodontal and autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (SLE). Similar mechanisms of tissue destruction concerning periodontitis and other autoimmune diseases have stimulated the study of a possible relationship between these conditions. This study aims to review the literature about this potential association and their different pathogenic mechanisms. Considering that periodontal disease is a disease characterized by inflammation influenced by infectious factors, such as SLE, it is plausible to suggest that SLE would influence periodontal disease and vice versa. However, this issue is not yet fully elucidated and several mechanisms have been proposed to explain this association, as deregulation mainly in innate immune system, with action of phagocytic cells and proinflammatory cytokines such as IL-1β and IL-18 in both conditions' pathogenesis, leading to tissue destruction. However, studies assessing the relationship between these diseases are scarce, and more studies focused on common immunological mechanisms should be conducted to further understanding. Copyright © 2015 Elsevier Editora Ltda. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, L.M.; Clayton, M.; Everingham, J.

A comparison of background and potential geopressured geothermal development-related subsidence rates is given. Estimated potential geopressured-related rates at six prospects are presented. The effect of subsidence on the Texas-Louisiana Gulf Coast is examined including the various associated ground movements and the possible effects of these ground movements on surficial processes. The relationships between ecosystems and subsidence, including the capability of geologic and biologic systems to adapt to subsidence, are analyzed. The actual potential for environmental impact caused by potential geopressured-related subsidence at each of four prospects is addressed. (MHR)

Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry

ERIC Educational Resources Information Center

Segerstrom, Suzanne C.; Miller, Gregory E.

2004-01-01

The present report meta-analyzes more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants. Acute stressors (lasting minutes) were associated with potentially adaptive upregulation of some parameters of natural immunity and downregulation of some functions of…

Mapping the Information Systems Curricula in UK Universities

ERIC Educational Resources Information Center

Stefanidis, Angelos; Fitzgerald, Guy

2010-01-01

Information Systems (IS) undergraduate student numbers in the UK have reduced by half in the last five years. An increasing number of researchers have been pondering the possible relationship between the modernity of IS curricula and its attractiveness to potential students. To support the debate about IS curricula in the UK and elsewhere, this…

An exploratory risk perception study of attitudes toward homeland security systems.

PubMed

Sanquist, Thomas F; Mahy, Heidi; Morris, Frederic

2008-08-01

Understanding the issues surrounding public acceptance of homeland security systems is important for balancing security needs and potential civil liberties infringements. A psychometric survey was used in an exploratory study of attitudes regarding homeland security systems. Psychometric rating data were obtained from 182 respondents on psychological attributes associated with 12 distinct types of homeland security systems. An inverse relationship was observed for the overall rating attributes of acceptability and risk of civil liberties infringement. Principal components analysis (PCA) yielded a two-factor solution with the rating scale loading pattern suggesting factors of perceived effectiveness and perceived intrusiveness. These factors also showed an inverse relationship. The 12 different homeland security systems showed significantly different scores on the rating scales and PCA factors. Of the 12 systems studied, airport screening, canine detectors, and radiation monitoring at borders were found to be the most acceptable, while email monitoring, data mining, and global positioning satellite (GPS) tracking were found to be least acceptable. Students rated several systems as more effective than professionals, but the overall pattern of results for both types of subjects was similar. The data suggest that risk perception research and the psychometric paradigm are useful approaches for quantifying attitudes regarding homeland security systems and policies and can be used to anticipate potentially significant public acceptance issues.

Muddying the waters: a new area of concern for drinking water contamination in Cameroon.

PubMed

Profitós, Jessica M Healy; Mouhaman, Arabi; Lee, Seungjun; Garabed, Rebecca; Moritz, Mark; Piperata, Barbara; Tien, Joe; Bisesi, Michael; Lee, Jiyoung

2014-11-28

In urban Maroua, Cameroon, improved drinking water sources are available to a large majority of the population, yet this water is frequently distributed through informal distribution systems and stored in home containers (canaries), leaving it vulnerable to contamination. We assessed where contamination occurs within the distribution system, determined potential sources of environmental contamination, and investigated potential pathogens. Gastrointestinal health status (785 individuals) was collected via health surveys. Drinking water samples were collected from drinking water sources and canaries. Escherichia coli and total coliform levels were evaluated and molecular detection was performed to measure human-associated faecal marker, HF183; tetracycline-resistance gene, tetQ; Campylobacter spp.; and Staphylococcus aureus. Statistical analyses were performed to evaluate the relationship between microbial contamination and gastrointestinal illness. Canari samples had higher levels of contamination than source samples. HF183 and tetQ were detected in home and source samples. An inverse relationship was found between tetQ and E. coli. Presence of tetQ with lower E. coli levels increased the odds of reported diarrhoeal illness than E. coli levels alone. Further work is warranted to better assess the relationship between antimicrobial-resistant bacteria and other pathogens in micro-ecosystems within canaries and this relationship's impact on drinking water quality.

Communication: Relationship between solute localization and diffusion in a dynamically constrained polymer system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saylor, David M.; Jawahery, Sudi; Silverstein, Joshua S.

2016-07-21

We investigate the link between dynamic localization, characterized by the Debye–Waller factor, 〈u{sup 2}〉, and solute self-diffusivity, D, in a polymer system using atomistic molecular dynamics simulations and vapor sorption experiments. We find a linear relationship between lnD and 1/〈u{sup 2}〉 over more than four decades of D, encompassing most of the glass formation regime. The observed linearity is consistent with the Langevin dynamics in a periodically varying potential field and may offer a means to rapidly assess diffusion based on the characterization of dynamic localization.

Cost-estimating relationships for space programs

NASA Technical Reports Server (NTRS)

Mandell, Humboldt C., Jr.

1992-01-01

Cost-estimating relationships (CERs) are defined and discussed as they relate to the estimation of theoretical costs for space programs. The paper primarily addresses CERs based on analogous relationships between physical and performance parameters to estimate future costs. Analytical estimation principles are reviewed examining the sources of errors in cost models, and the use of CERs is shown to be affected by organizational culture. Two paradigms for cost estimation are set forth: (1) the Rand paradigm for single-culture single-system methods; and (2) the Price paradigms that incorporate a set of cultural variables. For space programs that are potentially subject to even small cultural changes, the Price paradigms are argued to be more effective. The derivation and use of accurate CERs is important for developing effective cost models to analyze the potential of a given space program.

Personality correlates of individual differences in the recruitment of cognitive mechanisms when rewards are at stake.

PubMed

Heritage, Allan J; Long, Laura J; Woodman, Geoffrey F; Zald, David H

2018-02-01

Individuals differ greatly in their sensitivity to rewards and punishments. In the extreme, these differences are implicated in a range of psychiatric disorders from addiction to depression. However, it is unclear how these differences influence the recruitment of attention, working memory, and long-term memory when responding to potential rewards. Here, we used a rewarded memory-guided visual search task and ERPs to examine the influence of individual differences in self-reported reward/punishment sensitivity, as measured by the Behavioral Inhibition System (BIS)/Behavioral Activation System (BAS) scales, on the recruitment of cognitive mechanisms in conditions of potential reward. Select subscales of the BAS, including the fun seeking and reward responsiveness scales, showed unique relationships with context updating to reward cues and working memory maintenance of potentially rewarded stimuli. In contrast, BIS scores showed unique relationships with deployment of attention at different points in the task. These results suggest that sensitivity to rewards (i.e., BAS) and to punishment (i.e., BIS) may play an important role in the recruitment of specific and distinct cognitive mechanisms in conditions of potential rewards. © 2017 Society for Psychophysiological Research.

Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [(18)F]setoperone PET study.

PubMed

Gerretsen, Philip; Graff-Guerrero, Ariel; Menon, Mahesh; Pollock, Bruce G; Kapur, Shitij; Vasdev, Neil; Houle, Sylvain; Mamo, David

2010-01-01

Social behavior and desire for social relationships have been independently linked to the serotonergic system, the prefrontal cortex, especially the orbitofrontal cortex (OFC), and the anterior cingulate cortex (ACC). The goal of this study was to explore the role of serotonin 5HT(2A) receptors in these brain regions in forming and maintaining close interpersonal relationships. Twenty-four healthy subjects completed the Temperament and Character Inventory (TCI) prior to undergoing [(18)F]setoperone brain positron emission tomography (PET) to measure serotonin 5HT(2A) receptor availability within the OFC (BA 11 and 47) and ACC (BA 32). We explored the relationship between desire for social relationships, as measured by the TCI reward dependence (RD) scale, and 5HT(2A) receptor non-displaceable binding potential (BP(nd)) in these regions. Scores of RD were negatively correlated with 5HT(2A) BP(nd) in the ACC (BA 32, r = -.528, p = .012) and OFC (BA 11, r = -.489, p = .021; BA 47, r = -.501, p = .017). These correlations were corroborated by a voxel-wise analysis. These results suggest that the serotonergic system may have a regulatory effect on the OFC and ACC for establishing and maintaining social relationships.

Artificial Intelligence and Vocational Education: An Impending Confluence.

ERIC Educational Resources Information Center

Roth, Gene L.; McEwing, Richard A.

1986-01-01

Reports on the relatively new field of artificial intelligence and its relationship to vocational education. Compares human intelligence with artificial intelligence. Discusses expert systems, natural language technology, and current trends. Lists potential applications for vocational education. (CH)

Understanding the relationship between actual and potential evapotranspirations from long- term water balance analysis and flux observation

NASA Astrophysics Data System (ADS)

Yang, D.; Yang, H.; Sun, F.

2007-12-01

Increase in air temperature and decrease in pan evaporation was found to be common worldwide during the past half century. This results in controversy in view of the changes to the hydrological cycle. Increases in precipitation have been expected due to the Clausius¡§CClapyeron relation in that the specific humidity increases exponentially with the greenhouse-gas induced temperature increasing and confirmed by measurements over northern extratropical land areas. The hydrologic cycle is expected to be intensified (or accelerated). However, the decreased pan evaporation is found to be well related to the global dimming, i.e., the decreased solar radiation induced by the pollution increasing, thus evaporation (i.e., the latent heat flux) should be steadily decreasing from the energy balance perspective. Many researchers explained that the potential evaporation (usually measured by pan) is decreased with increasing of precipitation; however, the increased soil moisture (due to precipitation increasing) can be evaporated because of extra energy available. Therefore, the actual and potential evaporation are in complementary relationship, which is expected to unify the controversy between global warming and dimming. This means that pan evaporation decrease implicates acceleration of the global hydrologic cycle, i.e., increase in the terrestrial evaporation. Based on the complementary theory, many operational formulae have been introduced to estimated actual evaporation from the potential evaporation. Our recent water balance analysis of 108 catchments in non-humid regions of China has shown that there are no general opposite trends between potential and actual evaporation in the same period. A novel phenomenon has been found that the complementary relationships in evaporation are distinctly confirmed when the annual actual and potential evaporation are plotted against annual precipitation; However, complementary relationships disappear in many catchments when actual and potential evaporations are plotted against the time (year) during the same period. This means that complementary idea cannot provide universally correct predictions on the trend of actual evaporation only from the potential one. In this research, we examine the coupled water-energy balance based on Budyko hypothesis and proposed a conceptual model for predicting the inter-annual variability of annual water balance, and the change trends of water balances due to climate changes. The wet environment evaporation was defined as the boundary condition in the Bouchet hypothesis and introduced into complementary relationship (CR), which combined the actual evaporation with potential evaporation in an equation. However, the CR was derived in a closed system where no horizontal energy advection existed. The effect of the horizontal advection on the CR in a real open system was also analyzed in this study. Using the long-term water balance analysis in the 108 study catchments and flux observation at 7 sites in Asia monsoon region, the regional and seasonal variability of the complementary relationship was examined. Key Words: climate change, evapotranspiration, water balance, flux observation, Budyko hypothesis, Bouchet hypothesis

A nonlinear electrostatic potential change in the T-system of skeletal muscle detected under passive recording conditions using potentiometric dyes

PubMed Central

1990-01-01

Voltage-sensing dyes were used to examine the electrical behavior of the T-system under passive recording conditions similar to those commonly used to detect charge movement. These conditions are designed to eliminate all ionic currents and render the T-system potential linear with respect to the command potential applied at the surface membrane. However, we found an unexpected nonlinearity in the relationship between the dye signal from the T-system and the applied clamp potential. An additional voltage- and time-dependent optical signal appears over the same depolarizing range of potentials where change movement and mechanical activation occur. This nonlinearity is not associated with unblocked ionic currents and cannot be attributed to lack of voltage clamp control of the T-system, which appears to be good under these conditions. We propose that a local electrostatic potential change occurs in the T-system upon depolarization. An electrostatic potential would not be expected to extend beyond molecular distances of the membrane and therefore would be sensed by a charged dye in the membrane but not by the voltage clamp, which responds solely to the potential of the bulk solution. Results obtained with different dyes suggest that the location of the phenomena giving rise to the extra absorbance change is either intramembrane or at the inner surface of the T-system membrane. PMID:2299329

Environmental Redox Potential and Redox Capacity Concepts Using a Simple Polarographic Experiment

NASA Astrophysics Data System (ADS)

Pidello, Alejandro

2003-01-01

The redox status of a system may be analyzed in terms of the redox potential (redox intensity component) and the size of the pool of electrons able to be transferred (redox capacity component). In single chemical systems, both terms are thermodynamically related by means of the Nernst equation, the classical redox equilibrium equation. Consequently, either the redox potential measurement or the redox capacity may be used without distinction to define the redox characteristics of these systems. However, in natural environments, which are a complex mixture of compounds undergoing redox reactions in several stages of nonequilibrium, it is difficult to establish the relationships linking redox potential and redox capacity. In this situation, as suggested by various authors, the complementary use of intensity and capacity measurements improves the characterization of the redox status of these systems. The aim of this laboratory experiment is to enable undergraduate students of applied biology (agronomy, veterinary or environmental sciences) to distinguish clearly between redox potential and redox capacity concepts through concrete results obtained in complex natural system such as soil, and to discuss the ecological significance of both concepts.

Prediction of genotoxic potential of cosmetic ingredients by an in silico battery system consisting of a combination of an expert rule-based system and a statistics-based system.

PubMed

Aiba née Kaneko, Maki; Hirota, Morihiko; Kouzuki, Hirokazu; Mori, Masaaki

2015-02-01

Genotoxicity is the most commonly used endpoint to predict the carcinogenicity of chemicals. The International Conference on Harmonization (ICH) M7 Guideline on Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk offers guidance on (quantitative) structure-activity relationship ((Q)SAR) methodologies that predict the outcome of bacterial mutagenicity assay for actual and potential impurities. We examined the effectiveness of the (Q)SAR approach with the combination of DEREK NEXUS as an expert rule-based system and ADMEWorks as a statistics-based system for the prediction of not only mutagenic potential in the Ames test, but also genotoxic potential in mutagenicity and clastogenicity tests, using a data set of 342 chemicals extracted from the literature. The prediction of mutagenic potential or genotoxic potential by DEREK NEXUS or ADMEWorks showed high values of sensitivity and concordance, while prediction by the combination of DEREK NEXUS and ADMEWorks (battery system) showed the highest values of sensitivity and concordance among the three methods, but the lowest value of specificity. The number of false negatives was reduced with the battery system. We also separately predicted the mutagenic potential and genotoxic potential of 41 cosmetic ingredients listed in the International Nomenclature of Cosmetic Ingredients (INCI) among the 342 chemicals. Although specificity was low with the battery system, sensitivity and concordance were high. These results suggest that the battery system consisting of DEREK NEXUS and ADMEWorks is useful for prediction of genotoxic potential of chemicals, including cosmetic ingredients.

Coordination of the EMS system: an organizational theory approach.

PubMed

Narad, R A

1998-01-01

Emergency medical services (EMS) systems include autonomous organizations with high degrees of interdependence. The need to coordinate system participants has long been recognized but seldom achieved. This can be explained by organizational theory--specifically, the study of the relationships among organizations. Existing models identify the total system's functions, but fail to explain roles and relationships among the system's participants. Coordination among organizations is more difficult than coordination within an organization because of lack of an authority structure. The EMS system can be described as "a functionally interdependent system," consisting of multiple autonomous organizations with high degrees of interdependence in their technical functions. Communities have five potential management approaches, varying according to their aggressiveness. These are laissez-faire, where even voluntary coordination efforts are not tried; voluntary cooperation efforts, such as coordinating councils; external planning agencies without regulatory control; "framework organizations" with regulatory control over the system participants; and bureaucratization, placing the system participants within a single organizational hierarchy. The "multicratic organization" is a model for management of multiorganizational systems. A "system lead agency" plans joint activities and manages relationships among system participants in the way that the management of a uniorganization integrates departments. A lead agency is usually a unit of government or organized pursuant to government action, but a managed care organization can also fill this role. In extreme application of the model, the system is viewed as a framework and temporary modules are attached. Their interests are limited, as needed, to optimize the entire system. The lead agency sets policies affecting relationships of modules and policies crossing organizational boundaries.

Modeling in-situ pine root decomposition using data from a 60-year chronosequence

Treesearch

Kim H. Ludovici; Stanley J. Zarnoch; Daniel D. Richter

2002-01-01

Because the root system of a mature pine tree typically accounts for 20-30% of the total tree biomass, decomposition of large lateral roots and taproots following forest harvest and re-establishment potentially impact nutrient supply and carbon sequestration in pine systems over several decades. If the relationship between stump diameter and decomposition of...

Teachers' dispositional mindfulness and the quality of their relationships with children in Head Start classrooms.

PubMed

Becker, Brandon D; Gallagher, Kathleen C; Whitaker, Robert C

2017-12-01

The quality of teachers' relationships with children is a key predictor of children's later social emotional competence and academic achievement. Interventions to increase mindfulness among teachers have focused primarily on the impacts on teachers' subjective well-being, but not on the quality of their relationships with children. Furthermore, none of these interventions have involved preschool teachers. To consider the potential of mindfulness-based interventions to improve the quality of teachers' relationships with preschool-aged children, we examined data from an online survey of 1001 classroom teachers in 37 Pennsylvania Head Start Programs. Using path analysis we investigated the association between teachers' dispositional mindfulness and the quality of their relationships with children (conflict and closeness). We further examined whether this association was mediated by teacher depressive symptoms and moderated by perceived workplace stress. Higher levels of dispositional mindfulness among teachers were associated with higher quality relationships with children (less conflict and greater closeness). The association between greater dispositional mindfulness and less conflict was partially mediated by lower depressive symptoms, and the conditional direct effect of mindfulness on conflict was stronger when perceived workplace stress was lower. These findings suggest that preschool teachers who have higher levels of dispositional mindfulness may experience higher quality relationships with children in their classrooms. Interventions to increase levels of dispositional mindfulness among early childhood educators may improve their well-being along with the quality of their relationships with children, potentially impacting children's educational outcomes. The potential impacts of such interventions may be even stronger if structural and systemic changes are also made to reduce workplace stress. Copyright © 2017 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

Application of a distributed process-based hydrologic model to estimate the effects of forest road density on stormflows in the Southern Appalachians

Treesearch

Salli F. Dymond; W. Michael Aust; Stephen P. Prisley; Mark H. Eisenbies; James M. Vose

2014-01-01

Managed forests have historically been linked to watershed protection and flood mitigation. Research indicates that forests can potentially minimize peak flows during storm events, yet the relationship between forests and flooding is complex. Forest roads, usually found in managed systems, can potentially magnify the effects of forest harvesting on water yields. The...

Innate immune system and tissue regeneration in planarians: an area ripe for exploration.

PubMed

Peiris, T Harshani; Hoyer, Katrina K; Oviedo, Néstor J

2014-08-01

The immune system has been implicated as an important modulator of tissue regeneration. However, the mechanisms driving injury-induced immune response and tissue repair remain poorly understood. For over 200 years, planarians have been a classical model for studies on tissue regeneration, but the planarian immune system and its potential role in repair is largely unknown. We found through comparative genomic analysis and data mining that planarians contain many potential homologs of the innate immune system that are activated during injury and repair of adult tissues. These findings support the notion that the relationship between adult tissue repair and the immune system is an ancient feature of basal Bilateria. Further analysis of the planarian immune system during regeneration could potentially add to our understanding of how the innate immune system and inflammatory responses interplay with regenerative signals to induce scar-less tissue repair in the context of the adult organism. Copyright © 2014 Elsevier Ltd. All rights reserved.

Complex relationship between seasonal streamflow forecast skill and value in reservoir operations

NASA Astrophysics Data System (ADS)

Turner, Sean W. D.; Bennett, James C.; Robertson, David E.; Galelli, Stefano

2017-09-01

Considerable research effort has recently been directed at improving and operationalising ensemble seasonal streamflow forecasts. Whilst this creates new opportunities for improving the performance of water resources systems, there may also be associated risks. Here, we explore these potential risks by examining the sensitivity of forecast value (improvement in system performance brought about by adopting forecasts) to changes in the forecast skill for a range of hypothetical reservoir designs with contrasting operating objectives. Forecast-informed operations are simulated using rolling horizon, adaptive control and then benchmarked against optimised control rules to assess performance improvements. Results show that there exists a strong relationship between forecast skill and value for systems operated to maintain a target water level. But this relationship breaks down when the reservoir is operated to satisfy a target demand for water; good forecast accuracy does not necessarily translate into performance improvement. We show that the primary cause of this behaviour is the buffering role played by storage in water supply reservoirs, which renders the forecast superfluous for long periods of the operation. System performance depends primarily on forecast accuracy when critical decisions are made - namely during severe drought. As it is not possible to know in advance if a forecast will perform well at such moments, we advocate measuring the consistency of forecast performance, through bootstrap resampling, to indicate potential usefulness in storage operations. Our results highlight the need for sensitivity assessment in value-of-forecast studies involving reservoirs with supply objectives.

Complex relationship between seasonal streamflow forecast skill and value in reservoir operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turner, Sean W. D.; Bennett, James C.; Robertson, David E.

Considerable research effort has recently been directed at improving and operationalising ensemble seasonal streamflow forecasts. Whilst this creates new opportunities for improving the performance of water resources systems, there may also be associated risks. Here, we explore these potential risks by examining the sensitivity of forecast value (improvement in system performance brought about by adopting forecasts) to changes in the forecast skill for a range of hypothetical reservoir designs with contrasting operating objectives. Forecast-informed operations are simulated using rolling horizon, adaptive control and then benchmarked against optimised control rules to assess performance improvements. Results show that there exists a strongmore » relationship between forecast skill and value for systems operated to maintain a target water level. But this relationship breaks down when the reservoir is operated to satisfy a target demand for water; good forecast accuracy does not necessarily translate into performance improvement. We show that the primary cause of this behaviour is the buffering role played by storage in water supply reservoirs, which renders the forecast superfluous for long periods of the operation. System performance depends primarily on forecast accuracy when critical decisions are made – namely during severe drought. As it is not possible to know in advance if a forecast will perform well at such moments, we advocate measuring the consistency of forecast performance, through bootstrap resampling, to indicate potential usefulness in storage operations. Our results highlight the need for sensitivity assessment in value-of-forecast studies involving reservoirs with supply objectives.« less

Complex relationship between seasonal streamflow forecast skill and value in reservoir operations

DOE PAGES

Turner, Sean W. D.; Bennett, James C.; Robertson, David E.; ...

2017-09-28

Considerable research effort has recently been directed at improving and operationalising ensemble seasonal streamflow forecasts. Whilst this creates new opportunities for improving the performance of water resources systems, there may also be associated risks. Here, we explore these potential risks by examining the sensitivity of forecast value (improvement in system performance brought about by adopting forecasts) to changes in the forecast skill for a range of hypothetical reservoir designs with contrasting operating objectives. Forecast-informed operations are simulated using rolling horizon, adaptive control and then benchmarked against optimised control rules to assess performance improvements. Results show that there exists a strongmore » relationship between forecast skill and value for systems operated to maintain a target water level. But this relationship breaks down when the reservoir is operated to satisfy a target demand for water; good forecast accuracy does not necessarily translate into performance improvement. We show that the primary cause of this behaviour is the buffering role played by storage in water supply reservoirs, which renders the forecast superfluous for long periods of the operation. System performance depends primarily on forecast accuracy when critical decisions are made – namely during severe drought. As it is not possible to know in advance if a forecast will perform well at such moments, we advocate measuring the consistency of forecast performance, through bootstrap resampling, to indicate potential usefulness in storage operations. Our results highlight the need for sensitivity assessment in value-of-forecast studies involving reservoirs with supply objectives.« less

A Lack of Continuity in Education, Training, and Practice Violates the "Do No Harm" Principle.

PubMed

Englander, Robert; Carraccio, Carol

2018-03-01

The paradigm shift to competency-based medical education (CBME) is under way, but incomplete implementation is blunting the potential impact on learning and patient outcomes. The fundamental principles of CBME call for standardizing outcomes addressing population health needs, then allowing time-variable progression to achieving them. Operationalizing CBME principles requires continuity within and across phases of the education, training, and practice continuum. However, the piecemeal origin of the phases of the "continuum" has resulted in a sequence of undergraduate to graduate medical education to practice that may be continuous temporally but bears none of the integration of a true continuum.With these timed interruptions during phase transitions, learning is not reinforced because of a failure to integrate experiences. Brief block rotations for learners and ever-shorter supervisory assignments for faculty preclude the development of relationships. Without these relationships, feedback falls on deaf ears. Block rotations also disrupt learners' relationships with patients. The harms resulting from such a system include decreases in patient satisfaction with their care and learner satisfaction with their work. Learners in this block system also demonstrate an erosion of empathy compared with those in innovative longitudinal training models. In addition, higher patient mortality during intern transitions has been demonstrated.The current medical education system is violating the first principle of medicine: "Do no harm." Full implementation of competency-based, time-variable education and training, with fixed outcomes aligned with population health needs, continuity in learning and relationships, and support from a developmental program of assessment, holds great potential to stop this harm.

The effect of an external electric field on the growth of incongruent-melting material

NASA Astrophysics Data System (ADS)

Uda, Satoshi; Huang, Xinming; Wang, Shou-Qi

2005-02-01

The significance of an electric field on the crystallization process is differentiated into two consequences; (i) thermodynamic effect and (ii) growth-dynamic effect. The former modifies the chemical potential of the associated phases which changes the equilibrium phase relationship while the latter influences the solute transport, growth kinetics, surface creation and defect generation during growth. The intrinsic electric field generating during growth is attributed to the crystallization-related electromotive force and the thermoelectric power driven by the temperature gradient at the interface which influences the solute transport and solute partitioning. The external electric field was applied to the growth apparatus in the ternary system of La2O3- Ga2O3- SiO2 so that the chemical potential of both solid and liquid phases changed leading to the variation of the equilibrium phase relationship. Imposing a 500 V/cm electric field on the system moved the boundary of primary phase field of lanthanum gallate ( LaGaO3) and Ga-bearing lanthanum silicate ( La14GaxSi9-xO) toward the SiO2 apex by 5 mol% which clearly demonstrated the change of the phase relationship by the external electric field.

Behavioral aspects of automatic vehicle guidance : relationship between headway and driver comfort

DOT National Transportation Integrated Search

1997-01-01

Automation of road traffic has the potential to greatly improve the performance of traffic systems. The acceptance of automated driving may play an important role in the feasibility of automated vehicle guidance (AVG), comparable to automated highway...

Information Technologies and Workplace Learning.

ERIC Educational Resources Information Center

Roth, Gene L.

1995-01-01

Information technologies are important tools for individual, team, and organizational learning. Developments in virtual reality and the Internet, performance support systems that increase the efficiency of individuals and groups, and other innovations have the potential to enhance the relationship between work and learning. (SK)

Co-occurrence between marital aggression and parents' child abuse potential: the impact of cumulative stress.

PubMed

Margolin, Gayla; Gordis, Elana B

2003-06-01

Evidence suggests that marital aggression and parent-to-child aggression sometimes occur within the same family, but little is known about why certain families are vulnerable to multiple forms of family aggression. According to family systems theory, negative affect in one family relationship can spread to other family relationships. According to family stress theory, aversive circumstances increase families' vulnerability to disruption and conflict. Based on these theories, the present study tests the hypothesis that cumulative family stresses potentiate the association between marital aggression and parents' child abuse potential. In a series of additive interactional models, husband-to-wife aggression was linked to husbands' and wives' child abuse potential in a context of both high financial stress and high parenting stress but was not linked in a context of low stress. Wife-to-husband aggression was linked to wives', but not husbands', child abuse potential in a context of high stress. These results highlight the potential role of contextual factors in the pervasiveness of aggressive exchanges across multiple family subsystems.

Are GnRH and FSH potentially damaging factors in the cardiovascular system?

PubMed

Poljak, Z; Hulin, I; Maruscakova, L; Mladosievicova, B

2018-04-02

In the physiological view the human cardiomyocytes express receptors of gonadotropin-releasing hormone and follicle-stimulating hormone. The local effects of these hormones in the heart are related also to some interstitial cells, such as endothelial cells with follicle-stimulating hormone receptors and immune cells with gonadotropin-releasing hormone receptors. The administration of androgen deprivation therapy in patients with prostate cancer is associated with increased incidence of cardiovascular complications. It is suggested that negative action of this therapy on cardiovascular system is due to the loss of testosterone but also levels of gonadotropin-releasing hormone and follicle-stimulating hormone are changed by therapy. In this article we review the literature to date with an emphasis on recent investigation focused on potential role of abnormal gonadotropin-releasing hormone and follicle-stimulating hormone levels induced by gonadotropin-releasing hormone agonists on the cardiovascular risk. These facts exacerbate the complexity of specific hormone and cell relationships within heart and vessels. Androgen deprivation therapy reveals the physiological relationships between hormones and specific tissues that are not part of the endocrine system.

Defining the Relationship Between Human Error Classes and Technology Intervention Strategies

NASA Technical Reports Server (NTRS)

Wiegmann, Douglas A.; Rantanen, Eas M.

2003-01-01

The modus operandi in addressing human error in aviation systems is predominantly that of technological interventions or fixes. Such interventions exhibit considerable variability both in terms of sophistication and application. Some technological interventions address human error directly while others do so only indirectly. Some attempt to eliminate the occurrence of errors altogether whereas others look to reduce the negative consequences of these errors. In any case, technological interventions add to the complexity of the systems and may interact with other system components in unforeseeable ways and often create opportunities for novel human errors. Consequently, there is a need to develop standards for evaluating the potential safety benefit of each of these intervention products so that resources can be effectively invested to produce the biggest benefit to flight safety as well as to mitigate any adverse ramifications. The purpose of this project was to help define the relationship between human error and technological interventions, with the ultimate goal of developing a set of standards for evaluating or measuring the potential benefits of new human error fixes.

Chemistry of potentially prebiological natural products

NASA Astrophysics Data System (ADS)

Eschenmoser, Albert

1994-09-01

A relationship between what might be called a kinetic version of Le Chatelier's principle and chemical self-organization is considered. Some aspects of the search for a pre-RNA genetic system are discussed. Results of an experimental investigation on the pairing properties of alternative nucleic acid systems — including those of pyranosyl-RNA (‘p-RNA’), a constitutional isomer of RNA — are summarized.

On the role of general system theory for functional neuroimaging.

PubMed

Stephan, Klaas Enno

2004-12-01

One of the most important goals of neuroscience is to establish precise structure-function relationships in the brain. Since the 19th century, a major scientific endeavour has been to associate structurally distinct cortical regions with specific cognitive functions. This was traditionally accomplished by correlating microstructurally defined areas with lesion sites found in patients with specific neuropsychological symptoms. Modern neuroimaging techniques with high spatial resolution have promised an alternative approach, enabling non-invasive measurements of regionally specific changes of brain activity that are correlated with certain components of a cognitive process. Reviewing classic approaches towards brain structure-function relationships that are based on correlational approaches, this article argues that these approaches are not sufficient to provide an understanding of the operational principles of a dynamic system such as the brain but must be complemented by models based on general system theory. These models reflect the connectional structure of the system under investigation and emphasize context-dependent couplings between the system elements in terms of effective connectivity. The usefulness of system models whose parameters are fitted to measured functional imaging data for testing hypotheses about structure-function relationships in the brain and their potential for clinical applications is demonstrated by several empirical examples.

On the role of general system theory for functional neuroimaging

PubMed Central

Stephan, Klaas Enno

2004-01-01

One of the most important goals of neuroscience is to establish precise structure–function relationships in the brain. Since the 19th century, a major scientific endeavour has been to associate structurally distinct cortical regions with specific cognitive functions. This was traditionally accomplished by correlating microstructurally defined areas with lesion sites found in patients with specific neuropsychological symptoms. Modern neuroimaging techniques with high spatial resolution have promised an alternative approach, enabling non-invasive measurements of regionally specific changes of brain activity that are correlated with certain components of a cognitive process. Reviewing classic approaches towards brain structure–function relationships that are based on correlational approaches, this article argues that these approaches are not sufficient to provide an understanding of the operational principles of a dynamic system such as the brain but must be complemented by models based on general system theory. These models reflect the connectional structure of the system under investigation and emphasize context-dependent couplings between the system elements in terms of effective connectivity. The usefulness of system models whose parameters are fitted to measured functional imaging data for testing hypotheses about structure–function relationships in the brain and their potential for clinical applications is demonstrated by several empirical examples. PMID:15610393

Machine-assisted discovery of relationships in astronomy

NASA Astrophysics Data System (ADS)

Graham, Matthew J.; Djorgovski, S. G.; Mahabal, Ashish A.; Donalek, Ciro; Drake, Andrew J.

2013-05-01

High-volume feature-rich data sets are becoming the bread-and-butter of 21st century astronomy but present significant challenges to scientific discovery. In particular, identifying scientifically significant relationships between sets of parameters is non-trivial. Similar problems in biological and geosciences have led to the development of systems which can explore large parameter spaces and identify potentially interesting sets of associations. In this paper, we describe the application of automated discovery systems of relationships to astronomical data sets, focusing on an evolutionary programming technique and an information-theory technique. We demonstrate their use with classical astronomical relationships - the Hertzsprung-Russell diagram and the Fundamental Plane of elliptical galaxies. We also show how they work with the issue of binary classification which is relevant to the next generation of large synoptic sky surveys, such as the Large Synoptic Survey Telescope (LSST). We find that comparable results to more familiar techniques, such as decision trees, are achievable. Finally, we consider the reality of the relationships discovered and how this can be used for feature selection and extraction.

Exact analytic solution of position-dependent mass Schrödinger equation

NASA Astrophysics Data System (ADS)

Rajbongshi, Hangshadhar

2018-03-01

Exact analytic solution of position-dependent mass Schrödinger equation is generated by using extended transformation, a method of mapping a known system into a new system equipped with energy eigenvalues and corresponding wave functions. First order transformation is performed on D-dimensional radial Schrödinger equation with constant mass by taking trigonometric Pöschl-Teller potential as known system. The exactly solvable potentials with position-dependent mass generated for different choices of mass functions through first order transformation are also taken as known systems in the second order transformation performed on D-dimensional radial position-dependent mass Schrödinger equation. The solutions are fitted for "Zhu and Kroemer" ordering of ambiguity. All the wave functions corresponding to nonzero energy eigenvalues are normalizable. The new findings are that the normalizability condition of the wave functions remains independent of mass functions, and some of the generated potentials show a family relationship among themselves where power law potentials also get related to non-power law potentials and vice versa through the transformation.

How Do High-Performance Work Systems Affect Individual Outcomes: A Multilevel Perspective.

PubMed

Zhang, Junwei; Akhtar, M Naseer; Bal, P Matthijs; Zhang, Yajun; Talat, Usman

2018-01-01

Research on high-performance work systems (HPWS) has suggested that a potential disconnection may exist between organizational-level HPWS and employee experienced HPWS. However, few studies have identified factors that are implied within such a relationship. Using a sample of 397 employees, 84 line managers, and 21 HR executives in China, we examined whether line managers' goal congruence can reduce the difference between organizational-level HPWS and employee experienced HPWS. Furthermore, this study also theorized and tested organization-based self-esteem (OBSE) as a mediator in the associations between employee experienced HPWS and job performance and job satisfaction. Using multilevel analyses, we found that line managers' goal congruence strengthened the relationship between organizational-level HPWS and employee experienced HPWS, such that the relationship was significant and positive when line managers' goal congruence was high, but a non-significant relationship when line managers' goal congruence was low. Moreover, employee experienced HPWS indirectly affected job performance and job satisfaction through the mechanism of OBSE beyond social exchange perspective.

How Do High-Performance Work Systems Affect Individual Outcomes: A Multilevel Perspective

PubMed Central

Zhang, Junwei; Akhtar, M. Naseer; Bal, P. Matthijs; Zhang, Yajun; Talat, Usman

2018-01-01

Research on high-performance work systems (HPWS) has suggested that a potential disconnection may exist between organizational-level HPWS and employee experienced HPWS. However, few studies have identified factors that are implied within such a relationship. Using a sample of 397 employees, 84 line managers, and 21 HR executives in China, we examined whether line managers’ goal congruence can reduce the difference between organizational-level HPWS and employee experienced HPWS. Furthermore, this study also theorized and tested organization-based self-esteem (OBSE) as a mediator in the associations between employee experienced HPWS and job performance and job satisfaction. Using multilevel analyses, we found that line managers’ goal congruence strengthened the relationship between organizational-level HPWS and employee experienced HPWS, such that the relationship was significant and positive when line managers’ goal congruence was high, but a non-significant relationship when line managers’ goal congruence was low. Moreover, employee experienced HPWS indirectly affected job performance and job satisfaction through the mechanism of OBSE beyond social exchange perspective. PMID:29743875

Saddles and dynamics in a solvable mean-field model

NASA Astrophysics Data System (ADS)

Angelani, L.; Ruocco, G.; Zamponi, F.

2003-05-01

We use the saddle-approach, recently introduced in the numerical investigation of simple model liquids, in the analysis of a mean-field solvable system. The investigated system is the k-trigonometric model, a k-body interaction mean field system, that generalizes the trigonometric model introduced by Madan and Keyes [J. Chem. Phys. 98, 3342 (1993)] and that has been recently introduced to investigate the relationship between thermodynamics and topology of the configuration space. We find a close relationship between the properties of saddles (stationary points of the potential energy surface) visited by the system and the dynamics. In particular the temperature dependence of saddle order follows that of the diffusivity, both having an Arrhenius behavior at low temperature and a similar shape in the whole temperature range. Our results confirm the general usefulness of the saddle-approach in the interpretation of dynamical processes taking place in interacting systems.

The Consumer Health Information System Adoption Model.

PubMed

Monkman, Helen; Kushniruk, Andre W

2015-01-01

Derived from overlapping concepts in consumer health, a consumer health information system refers to any of the broad range of applications, tools, and educational resources developed to empower consumers with knowledge, techniques, and strategies, to manage their own health. As consumer health information systems become increasingly popular, it is important to explore the factors that impact their adoption and success. Accumulating evidence indicates a relationship between usability and consumers' eHealth Literacy skills and the demands consumer HISs place on their skills. Here, we present a new model called the Consumer Health Information System Adoption Model, which depicts both consumer eHealth literacy skills and system demands on eHealth literacy as moderators with the potential to affect the strength of relationship between usefulness and usability (predictors of usage) and adoption, value, and successful use (actual usage outcomes). Strategies for aligning these two moderating factors are described.

The picture exchange communication system.

PubMed

Bondy, A S; Frost, L A

1998-01-01

The Picture Exchange Communication System (PECS) was developed as a means to teach children with autism and related developmental disabilities a rapidly acquired, self-initiating, functional communication system. Its theoretical roots combine principles from applied behavior analysis and guidelines established within the field of alternative and augmentative communication. This approach has several potential advantages relative to imitation-based strategies (both vocal and gestural) and symbol selection strategies. The system begins with the exchange of simple icons but rapidly builds "sentence" structure. The system also emphasizes developing the request function prior to developing responding to simple questions and commenting. The development of requesting with a sentence structure also permits the rapid development of attributes more traditionally taught within a receptive mode. The relationship between the introduction of PECS and various other behavioral issues (i.e., social approach and behavior management) as well as its relationship to the codevelopment of speech are reviewed.

Sources of endocrine-disrupting compounds in North Carolina waterways: a geographic information systems approach

USGS Publications Warehouse

Sackett, Dana K.; Pow, Crystal Lee; Rubino, Matthew J.; Aday, D.D.; Cope, W. Gregory; Kullman, Seth W.; Rice, J.A.; Kwak, Thomas J.; Law, L.M.

2015-01-01

The presence of endocrine-disrupting compounds (EDCs), particularly estrogenic compounds, in the environment has drawn public attention across the globe, yet a clear understanding of the extent and distribution of estrogenic EDCs in surface waters and their relationship to potential sources is lacking. The objective of the present study was to identify and examine the potential input of estrogenic EDC sources in North Carolina water bodies using a geographic information system (GIS) mapping and analysis approach. Existing data from state and federal agencies were used to create point and nonpoint source maps depicting the cumulative contribution of potential sources of estrogenic EDCs to North Carolina surface waters. Water was collected from 33 sites (12 associated with potential point sources, 12 associated with potential nonpoint sources, and 9 reference), to validate the predictive results of the GIS analysis. Estrogenicity (measured as 17β-estradiol equivalence) ranged from 0.06 ng/L to 56.9 ng/L. However, the majority of sites (88%) had water 17β-estradiol concentrations below 1 ng/L. Sites associated with point and nonpoint sources had significantly higher 17β-estradiol levels than reference sites. The results suggested that water 17β-estradiol was reflective of GIS predictions, confirming the relevance of landscape-level influences on water quality and validating the GIS approach to characterize such relationships.

Sources of endocrine-disrupting compounds in North Carolina waterways: a geographic information systems approach.

PubMed

Sackett, Dana K; Pow, Crystal Lee; Rubino, Matthew J; Aday, D Derek; Cope, W Gregory; Kullman, Seth; Rice, James A; Kwak, Thomas J; Law, Mac

2015-02-01

The presence of endocrine-disrupting compounds (EDCs), particularly estrogenic compounds, in the environment has drawn public attention across the globe, yet a clear understanding of the extent and distribution of estrogenic EDCs in surface waters and their relationship to potential sources is lacking. The objective of the present study was to identify and examine the potential input of estrogenic EDC sources in North Carolina water bodies using a geographic information system (GIS) mapping and analysis approach. Existing data from state and federal agencies were used to create point and nonpoint source maps depicting the cumulative contribution of potential sources of estrogenic EDCs to North Carolina surface waters. Water was collected from 33 sites (12 associated with potential point sources, 12 associated with potential nonpoint sources, and 9 reference), to validate the predictive results of the GIS analysis. Estrogenicity (measured as 17β-estradiol equivalence) ranged from 0.06 ng/L to 56.9 ng/L. However, the majority of sites (88%) had water 17β-estradiol concentrations below 1 ng/L. Sites associated with point and nonpoint sources had significantly higher 17β-estradiol levels than reference sites. The results suggested that water 17β-estradiol was reflective of GIS predictions, confirming the relevance of landscape-level influences on water quality and validating the GIS approach to characterize such relationships. © 2014 SETAC.

Analysis of genetic admixture in Uyghur using the 26 Y-STR loci system

PubMed Central

Bian, Yingnan; Zhang, Suhua; Zhou, Wei; Zhao, Qi; Siqintuya; Zhu, Ruxin; Wang, Zheng; Gao, Yuzhen; Hong, Jie; Lu, Daru; Li, Chengtao

2016-01-01

The Uyghur population has experienced extensive interaction with European and Eastern Asian populations historically. A set of high-resolution genetic markers could be useful to infer the genetic relationships between the Uyghur population and European and Asian populations. In this study we typed 100 unrelated Uyghur males living in southern Xinjiang at 26 Y-STR loci. Using the high-resolution 26 Y-STR loci system, we investigated genetic and phylogenetic relationship between the Uyghur population and 23 reference European or Asian populations. We found that the Uyghur population exhibited a genetic admixture of Eastern Asian and European populations, and had a slightly closer relationship with the selected European populations than the Eastern Asian populations. We also demonstrated that the 26 Y-STR loci system was potentially useful in forensic sciences because it has a large power of discrimination and rarely exhibits common haplotypes. However, ancestry inference of Uyghur samples could be challenging due to the admixed nature of the population. PMID:26842947

Analysis of genetic admixture in Uyghur using the 26 Y-STR loci system.

PubMed

Bian, Yingnan; Zhang, Suhua; Zhou, Wei; Zhao, Qi; Siqintuya; Zhu, Ruxin; Wang, Zheng; Gao, Yuzhen; Hong, Jie; Lu, Daru; Li, Chengtao

2016-02-04

The Uyghur population has experienced extensive interaction with European and Eastern Asian populations historically. A set of high-resolution genetic markers could be useful to infer the genetic relationships between the Uyghur population and European and Asian populations. In this study we typed 100 unrelated Uyghur males living in southern Xinjiang at 26 Y-STR loci. Using the high-resolution 26 Y-STR loci system, we investigated genetic and phylogenetic relationship between the Uyghur population and 23 reference European or Asian populations. We found that the Uyghur population exhibited a genetic admixture of Eastern Asian and European populations, and had a slightly closer relationship with the selected European populations than the Eastern Asian populations. We also demonstrated that the 26 Y-STR loci system was potentially useful in forensic sciences because it has a large power of discrimination and rarely exhibits common haplotypes. However, ancestry inference of Uyghur samples could be challenging due to the admixed nature of the population.

Elementary Hemodynamic Principles Based on Modified Bernoulli's Equation.

ERIC Educational Resources Information Center

Badeer, Henry S.

1985-01-01

Develops and expands basic concepts of Bernoulli's equation as it applies to vascular hemodynamics. Simple models are used to illustrate gravitational potential energy, steady nonturbulent flow, pump-driven streamline flow, and other areas. Relationships to the circulatory system are also discussed. (DH)

Influence of pressure on the crystallization of systems characterized by different intermolecular attraction

NASA Astrophysics Data System (ADS)

Koperwas, K.; Affouard, F.; Gerges, J.; Valdes, L.-C.; Adrjanowicz, K.; Paluch, M.

2017-12-01

In this paper, we examine, in terms of the classical nucleation theory, how the strengthening of the attractive intermolecular interactions influences the crystallization process for systems like Lennard-Jones at different isobaric conditions. For this purpose, we modify the standard Lennard-Jones potential, and as a result, we obtain three different systems characterized by various strengths of attractive potentials occurring between molecules, which are in direct relationship to the physical quantities describing molecules, e.g., its polarizability or dipole moment. Based on performed analysis, we demonstrate that the molecular attraction primarily impacts the thermodynamics of the interface between liquid and crystal. This is reflected in the behavior of nucleation and overall crystallization rates during compression of the system.

A unified framework for addiction: Vulnerabilities in the decision process

PubMed Central

Redish, A. David; Jensen, Steve; Johnson, Adam

2013-01-01

The understanding of decision-making systems has come together in recent years to form a unified theory of decision-making in the mammalian brain as arising from multiple, interacting systems (a planning system, a habit system, and a situation-recognition system). This unified decision-making system has multiple potential access points through which it can be driven to make maladaptive choices, particularly choices that entail seeking of certain drugs or behaviors. We identify 10 key vulnerabilities in the system: (1) moving away from homeostasis, (2) changing allostatic set points, (3) euphorigenic “reward-like” signals, (4) overvaluation in the planning system, (5) incorrect search of situation-action-outcome relationships, (6) misclassification of situations, (7) overvaluation in the habit system, (8) a mismatch in the balance of the two decision systems, (9) over-fast discounting processes, and (10) changed learning rates. These vulnerabilities provide a taxonomy of potential problems with decision-making systems. Although each vulnerability can drive an agent to return to the addictive choice, each vulnerability also implies a characteristic symptomology. Different drugs, different behaviors, and different individuals are likely to access different vulnerabilities. This has implications for an individual’s susceptibility to addiction and the transition to addiction, for the potential for relapse, and for the potential for treatment. PMID:18662461

Somatotopic Semantic Priming and Prediction in the Motor System

PubMed Central

Grisoni, Luigi; Dreyer, Felix R.; Pulvermüller, Friedemann

2016-01-01

The recognition of action-related sounds and words activates motor regions, reflecting the semantic grounding of these symbols in action information; in addition, motor cortex exerts causal influences on sound perception and language comprehension. However, proponents of classic symbolic theories still dispute the role of modality-preferential systems such as the motor cortex in the semantic processing of meaningful stimuli. To clarify whether the motor system carries semantic processes, we investigated neurophysiological indexes of semantic relationships between action-related sounds and words. Event-related potentials revealed that action-related words produced significantly larger stimulus-evoked (Mismatch Negativity-like) and predictive brain responses (Readiness Potentials) when presented in body-part-incongruent sound contexts (e.g., “kiss” in footstep sound context; “kick” in whistle context) than in body-part-congruent contexts, a pattern reminiscent of neurophysiological correlates of semantic priming. Cortical generators of the semantic relatedness effect were localized in areas traditionally associated with semantic memory, including left inferior frontal cortex and temporal pole, and, crucially, in motor areas, where body-part congruency of action sound–word relationships was indexed by a somatotopic pattern of activation. As our results show neurophysiological manifestations of action-semantic priming in the motor cortex, they prove semantic processing in the motor system and thus in a modality-preferential system of the human brain. PMID:26908635

Regulation of Complement and Contact System Activation via C1 Inhibitor Potentiation and Factor XIIa Activity Modulation by Sulfated Glycans – Structure-Activity Relationships

PubMed Central

Schoenfeld, Ann-Kathrin; Lahrsen, Eric; Alban, Susanne

2016-01-01

The serpin C1 inhibitor (C1-INH) is the only regulator of classical complement activation as well as the major regulator of the contact system. Its importance is demonstrated by hereditary angioedema (HAE), a severe disease with potentially life-threatening attacks due to deficiency or dysfunction of C1-INH. C1-INH replacement is the therapy of choice in HAE. In addition, C1-INH showed to have beneficial effects in other diseases characterized by inappropriate complement and contact system activation. Due to some limitations of its clinical application, there is a need for improving the efficacy of therapeutically applied C1-INH or to enhance the activity of endogenous C1-INH. Given the known potentiating effect of heparin on C1-INH, sulfated glycans (SG) may be such candidates. The aim of this study was to characterize suitable SG by evaluating structure-activity relationships. For this, more than 40 structurally distinct SG were examined for their effects on C1-INH, C1s and FXIIa. The SG turned out to potentiate the C1s inhibition by C1-INH without any direct influence on C1s. Their potentiating activity proved to depend on their degree of sulfation, molecular mass as well as glycan structure. In contrast, the SG had no effect on the FXIIa inhibition by C1-INH, but structure-dependently modulated the activity of FXIIa. Among the tested SG, β-1,3-glucan sulfates with a Mr ≤ 10 000 were identified as most promising lead candidates for the development of a glycan-based C1-INH amplifier. In conclusion, the obtained information on structural characteristics of SG favoring C1-INH potentiation represent an useful elementary basis for the development of compounds improving the potency of C1-INH in diseases and clinical situations characterized by inappropriate activation of complement and contact system. PMID:27783665

Why nurses can be key partners in securing philanthropic investments.

PubMed

Rivet, Nicole

2014-01-01

Fund-raisers can truly benefit from collaborating with nurses when they are seeking philanthropic support for their health care systems. Fund-raising is about developing new relationships with potential prospects and strengthening those with current donors. Nurses frequently have some of the best relationships with patients, and they often lead efforts to improve the quality of care in their hospitals. Their professional experience and their ability to connect with people are invaluable skills that can help secure philanthropic investments.

Does the organizational structure of health care systems influence care-seeking decisions? A qualitative analysis of Danish cancer patients' reflections on care-seeking.

PubMed

Andersen, Rikke Sand; Vedsted, Peter; Olesen, Frede; Bro, Flemming; Søndergaard, Jens

2011-09-01

The absence of a more significant improvement in cancer survival in countries such as the UK and Denmark may be partly rooted in delayed care-seeking among cancer patients. Past research on patient delay has mainly focused on patient characteristics (e.g. sociodemographic and psychological factors and symptom recognition) as causes of delayed care-seeking, while few studies have examined how the organizational structure of health care systems may influence patients' reflections on seeking care. The aim of this study was to explore this relationship. The analysis presented is based on semi-structured interviews with 30 cancer patients and their families. The article raises two hypotheses on the relationship between structural elements of a health care system and people's reflections on seeking health care: (1) Gatekeeping introduces an asymmetrical relationship between the patient and the GP which potentially results in self-restricting care-seeking, (2) Continuity in the doctor-patient relationship may negatively influence patient reflections on access to health care, as the focus shifts from the medical issues of the consultation to reflections on how to properly interact with the GP and the system in which she/he is situated. It is concluded that these hypotheses form a sound basis for further primary care research on how the organizational structure of health care systems influences patient reflections on access to medical care.

Theoretical study of production of unique glasses in space. [kinetic relationships describing nucleation and crystallization phenomena

NASA Technical Reports Server (NTRS)

Larsen, D. C.; Sievert, J. L.

1975-01-01

The potential of producing the glassy form of selected materials in the weightless, containerless nature of space processing is examined through the development of kinetic relationships describing nucleation and crystallization phenomena. Transformation kinetics are applied to a well-characterized system (SiO2), an excellent glass former (B2O3), and a poor glass former (Al2O3) by conventional earth processing methods. Viscosity and entropy of fusion are shown to be the primary materials parameters controlling the glass forming tendency. For multicomponent systems diffusion-controlled kinetics and heterogeneous nucleation effects are considered. An analytical empirical approach is used to analyze the mullite system. Results are consistent with experimentally observed data and indicate the promise of mullite as a future space processing candidate.

Planning Your Retirement.

ERIC Educational Resources Information Center

American Association of Retired Persons, Washington, DC.

This guidebook on retirement planning helps potential retirees by raising important issues in such areas as changing roles and relationships, health and fitness, meaningful use of time, working options, financial and estate planning, and housing and lifestyle. The first section, on attitude and role adjustments, discusses support systems, changing…

Development of test systems for characterizing emissions from spray polyurethane foam insulation (SPFI)

EPA Science Inventory

The relationship between onsite manufacture of spray polyurethane foam insulation (SPFI) and potential exposures to diisocyanates, amines, flame retardants (FRs), blowing agents, aldehydes and other organic compounds that may be emitted from SPFI is not well understood. EPA is de...

Systems Engineering and Integration as a Foundation for Mission Engineering

DTIC Science & Technology

2015-09-01

parallels the INCOSE definition to develop a system, it is important to note the focus on a complete life cycle balanced solution and the satisfaction of...unacceptable to relevant stakeholders. Principle 7 Managers should acknowledge the potential conflicts between (a) their own role as corporate...engineer in understanding the relationships between various needs and to identify similarities, differences, or redundancies. Another method for

Models of Physiology/Cognition Relations: Their Prevalence in the Literature and Their Utility in Examining the Effect of Blood Pressure on Vocabulary and Memory for Designs.

ERIC Educational Resources Information Center

Sinnott, Jan D.; And Others

Interest in physiology/cognition relations is increasing, in step with the realization that the individual ages as a whole, adaptive, living system. If a physiological system declines, a person's cognitive abilities may be reduced, unless some compensatory mechanism operates. Understanding this set of relationships permits potential interventions.…

Stereoscopic Configurations To Minimize Distortions

NASA Technical Reports Server (NTRS)

Diner, Daniel B.

1991-01-01

Proposed television system provides two stereoscopic displays. Two-camera, two-monitor system used in various camera configurations and with stereoscopic images on monitors magnified to various degrees. Designed to satisfy observer's need to perceive spatial relationships accurately throughout workspace or to perceive them at high resolution in small region of workspace. Potential applications include industrial, medical, and entertainment imaging and monitoring and control of telemanipulators, telerobots, and remotely piloted vehicles.

Two-tier Haddon matrix approach to fault analysis of accidents and cybernetic search for relationship to effect operational control: a case study at a large construction site.

PubMed

Mazumdar, Atmadeep; Sen, Krishna Nirmalya; Lahiri, Balendra Nath

2007-01-01

The Haddon matrix is a potential tool for recognizing hazards in any operating engineering system. This paper presents a case study of operational hazards at a large construction site. The fish bone structure helps to visualize and relate the chain of events, which led to the failure of the system. The two-tier Haddon matrix approach helps to analyze the problem and subsequently prescribes preventive steps. The cybernetic approach has been undertaken to establish the relationship among event variables and to identify the ones with most potential. Those event variables in this case study, based on the cybernetic concepts like control responsiveness and controllability salience, are (a) uncontrolled swing of sheet contributing to energy, (b) slippage of sheet from anchor, (c) restricted longitudinal and transverse swing or rotation about the suspension, (d) guilt or uncertainty of the crane driver, (e) safe working practices and environment.

Agroforestry Practices Promote Biodiversity and Natural Resource Diversity in Atlantic Nicaragua.

PubMed

Sistla, Seeta A; Roddy, Adam B; Williams, Nicholas E; Kramer, Daniel B; Stevens, Kara; Allison, Steven D

2016-01-01

Tropical forest conversion to pasture, which drives greenhouse gas emissions, soil degradation, and biodiversity loss, remains a pressing socio-ecological challenge. This problem has spurred increased interest in the potential of small-scale agroforestry systems to couple sustainable agriculture with biodiversity conservation, particularly in rapidly developing areas of the tropics. In addition to providing natural resources (i.e. food, medicine, lumber), agroforestry systems have the potential to maintain higher levels of biodiversity and greater biomass than lower diversity crop or pasture systems. Greater plant diversity may also enhance soil quality, further supporting agricultural productivity in nutrient-limited tropical systems. Yet, the nature of these relationships remains equivocal. To better understand how different land use strategies impact ecosystem services, we characterized the relationships between plant diversity (including species richness, phylogenetic diversity, and natural resource diversity), and soil quality within pasture, agroforests, and secondary forests, three common land use types maintained by small-scale farmers in the Pearl Lagoon Basin, Nicaragua. The area is undergoing accelerated globalization following the 2007 completion of the region's first major road; a change which is expected to increase forest conversion for agriculture. However, farmer agrobiodiversity maintenance in the Basin was previously found to be positively correlated with affiliation to local agricultural NGOs through the maintenance of agroforestry systems, despite these farmers residing in the communities closest to the new road, highlighting the potential for maintaining diverse agroforestry agricultural strategies despite heightened globalization pressures. We found that agroforestry sites tended to have higher surface soil %C, %N, and pH relative to neighboring to secondary forest, while maintaining comparable plant diversity. In contrast, pasture reduced species richness, phylogenetic diversity, and natural resource diversity. No significant relationships were found between plant diversity and the soil properties assessed; however higher species richness and phylodiversity was positively correlated with natural resource diversity. These finding suggest that small, diversified agroforestry systems may be a viable strategy for promoting both social and ecological functions in eastern Nicaragua and other rapidly developing areas of the tropics.

Agroforestry Practices Promote Biodiversity and Natural Resource Diversity in Atlantic Nicaragua

PubMed Central

Sistla, Seeta A.; Roddy, Adam B.; Williams, Nicholas E.; Kramer, Daniel B.; Stevens, Kara; Allison, Steven D.

2016-01-01

Tropical forest conversion to pasture, which drives greenhouse gas emissions, soil degradation, and biodiversity loss, remains a pressing socio-ecological challenge. This problem has spurred increased interest in the potential of small-scale agroforestry systems to couple sustainable agriculture with biodiversity conservation, particularly in rapidly developing areas of the tropics. In addition to providing natural resources (i.e. food, medicine, lumber), agroforestry systems have the potential to maintain higher levels of biodiversity and greater biomass than lower diversity crop or pasture systems. Greater plant diversity may also enhance soil quality, further supporting agricultural productivity in nutrient-limited tropical systems. Yet, the nature of these relationships remains equivocal. To better understand how different land use strategies impact ecosystem services, we characterized the relationships between plant diversity (including species richness, phylogenetic diversity, and natural resource diversity), and soil quality within pasture, agroforests, and secondary forests, three common land use types maintained by small-scale farmers in the Pearl Lagoon Basin, Nicaragua. The area is undergoing accelerated globalization following the 2007 completion of the region’s first major road; a change which is expected to increase forest conversion for agriculture. However, farmer agrobiodiversity maintenance in the Basin was previously found to be positively correlated with affiliation to local agricultural NGOs through the maintenance of agroforestry systems, despite these farmers residing in the communities closest to the new road, highlighting the potential for maintaining diverse agroforestry agricultural strategies despite heightened globalization pressures. We found that agroforestry sites tended to have higher surface soil %C, %N, and pH relative to neighboring to secondary forest, while maintaining comparable plant diversity. In contrast, pasture reduced species richness, phylogenetic diversity, and natural resource diversity. No significant relationships were found between plant diversity and the soil properties assessed; however higher species richness and phylodiversity was positively correlated with natural resource diversity. These finding suggest that small, diversified agroforestry systems may be a viable strategy for promoting both social and ecological functions in eastern Nicaragua and other rapidly developing areas of the tropics. PMID:27606619

Calculation of surface potentials at the silica–water interface using molecular dynamics: Challenges and opportunities

NASA Astrophysics Data System (ADS)

Lowe, Benjamin M.; Skylaris, Chris-Kriton; Green, Nicolas G.; Shibuta, Yasushi; Sakata, Toshiya

2018-04-01

Continuum-based methods are important in calculating electrostatic properties of interfacial systems such as the electric field and surface potential but are incapable of providing sufficient insight into a range of fundamentally and technologically important phenomena which occur at atomistic length-scales. In this work a molecular dynamics methodology is presented for interfacial electric field and potential calculations. The silica–water interface was chosen as an example system, which is highly relevant for understanding the response of field-effect transistors sensors (FET sensors). Detailed validation work is presented, followed by the simulated surface charge/surface potential relationship. This showed good agreement with experiment at low surface charge density but at high surface charge density the results highlighted challenges presented by an atomistic definition of the surface potential. This methodology will be used to investigate the effect of surface morphology and biomolecule addition; both factors which are challenging using conventional continuum models.

[Corruption risks in relations between doctor and patient ].

PubMed

Kolwitz, Marcin; Gąsiorowski, Jakub

2014-01-01

The article describes the problem of corruption occurring in the relationship between doctor and patient. The doctor-patient relationship, including the provision of health services, is one of several potential areas of corruption in the health care system. Among the reasons for the existence of corruption in these relationships are the need to obtain better healthcare for the patient, and higher earnings in the case of a doctor. Indications of corruption are utilitarian (action for personal advantage without ethical aspects), but may also be (actually or in the patient's opinion) the only way to obtain services and save health and even life. Corruption between the doctor and the patient can be limited by better organization of the health care system, including the financing of benefits and education of medical personnel and patients, as well as traditional legal measures, such as prevention or the application of criminal sanctions.

Examining the Relationship Between Edaphic Variables and the Rooting System of Abies concolor in the southern Sierra Nevada

NASA Astrophysics Data System (ADS)

Wilson, A.; Jackson, R. B.; Tumber-Davila, S. J.

2017-12-01

An increase in the frequency and severity of droughts has been associated with the changing climate. These events have the potential to alter the composition and biogeography of forests, as well as increase tree mortality related to climate-induced stress. Already, an increase in tree mortality has been observed throughout the US. The recent drought in California led to millions of tree mortalities in the southern Sierra Nevada alone. In order to assess the potential impacts of these events on forest systems, it is imperative to understand what factors contribute to tree mortality. As plants become water-stressed, they may invest carbon more heavily belowground to reach a bigger pool of water, but their ability to adapt may be limited by the characteristics of the soil. In the Southern Sierra Critical Zone Observatory, a high tree mortality zone, we have selected both dead and living trees to examine the factors that contribute to root zone variability and belowground biomass investment by individual plants. A series of 15 cores surrounding the tree were taken to collect root and soil samples. These were then used to compare belowground rooting distributions with soil characteristics (texture, water holding capacity, pH, electric conductivity). Abies concolor is heavily affected by drought-induced mortality, therefore the rooting systems of dead Abies concolor trees were examined to determine the relationship between their rooting systems and environmental conditions. Examining the relationship between soil characteristics and rooting systems of trees may shed light on the plasticity of rooting systems and how trees adapt based on the characteristics of its environment. A better understanding of the factors that contribute to tree mortality can improve our ability to predict how forest systems may be impacted by climate-induced stress. Key words: Root systems, soil characteristics, drought, adaptation, terrestrial carbon, forest ecology

Simulation Of Wave Function And Probability Density Of Modified Poschl Teller Potential Derived Using Supersymmetric Quantum Mechanics

NASA Astrophysics Data System (ADS)

Angraini, Lily Maysari; Suparmi, Variani, Viska Inda

2010-12-01

SUSY quantum mechanics can be applied to solve Schrodinger equation for high dimensional system that can be reduced into one dimensional system and represented in lowering and raising operators. Lowering and raising operators can be obtained using relationship between original Hamiltonian equation and the (super) potential equation. In this paper SUSY quantum mechanics is used as a method to obtain the wave function and the energy level of the Modified Poschl Teller potential. The graph of wave function equation and probability density is simulated by using Delphi 7.0 programming language. Finally, the expectation value of quantum mechanics operator could be calculated analytically using integral form or probability density graph resulted by the programming.

Cladistical Analysis of the Jovian and Saturnian Satellite Systems

NASA Astrophysics Data System (ADS)

Holt, Timothy. R.; Brown, Adrian. J.; Nesvorný, David; Horner, Jonathan; Carter, Brad

2018-06-01

Jupiter and Saturn each have complex systems of satellites and rings. These satellites can be classified into dynamical groups, implying similar formation scenarios. Recently, a larger number of additional irregular satellites have been discovered around both gas giants that have yet to be classified. The aim of this paper is to examine the relationships between the satellites and rings of the gas giants, using an analytical technique called cladistics. Cladistics is traditionally used to examine relationships between living organisms, the “tree of life.” In this work, we perform the first cladistical study of objects in a planetary science context. Our method uses the orbital, physical, and compositional characteristics of satellites to classify the objects in the Jovian and Saturnian systems. We find that the major relationships between the satellites in the two systems, such as families, as presented in previous studies, are broadly preserved. In addition, based on our analysis of the Jovian system, we identify a new retrograde irregular family, the Iocaste family, and suggest that the Phoebe family of the Saturnian system can be further divided into two subfamilies. We also propose that the Saturnian irregular families be renamed, to be consistent with the convention used in Jovian families. Using cladistics, we are also able to assign the new unclassified irregular satellites into families. Taken together, the results of this study demonstrate the potential use of the cladistical technique in the investigation of relationships between orbital bodies.

The effects of harvest on waterfowl populations

USGS Publications Warehouse

Cooch, Evan G.; Guillemain, Matthieu; Boomer, G Scott; Lebreton, Jean-Dominique; Nichols, James D.

2014-01-01

Overall, there is substantial uncertainty about system dynamics, about the impacts of potential management and conservation decisions on those dynamics, and how to optimise management decisions in the presence of such uncertainties. Such relationships are unlikely to be stationary over space or time, and selective harvest of some individuals can potentially alter life history allocation of resources over time – both of which will potentially influence optimal harvest strategies. These sources of variation and uncertainty argue for the use of adaptive approaches to waterfowl harvest management.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanquist, Thomas F.; Mahy, Heidi A.; Morris, Fred A.

Understanding the issues surrounding public acceptance of homeland security systems is important for balancing security needs and potential civil liberties infringements. A psychometric survey was used to measure attitudes regarding homeland security systems. Psychometric rating data were obtained from 182 respondents on psychological attributes associated with 12 distinct types of homeland security systems. An inverse relationship was observed for the overall rating attributes of acceptability and risk of civil liberties infringement. Principal components analysis yielded a two factor solution, with the rating scale loading pattern suggesting factors of Perceived Effectiveness and Perceived Intrusiveness. These factors also showed an inverse relationship.more » The 12 different homeland security systems showed significantly different scores on the rating scales and PCA factors, which were used to rank the systems in terms of overall acceptability. Difference scores for the rating scales and PCA factors were used to compute a single acceptability value reflecting the relative weight of risks and benefits. Of the 12 systems studied, airport screening, canine detectors and radiation monitoring at borders were found to be relatively acceptable, i.e., the perceived benefits for homeland security outweighed the perceived risks to civil liberties. Students rated several systems as more effective than professionals, but the overall pattern of results for both types of subjects was similar. The data suggest that risk perception research and the psychometric paradigm are useful approaches for quantifying attitudes regarding homeland security systems and policies, and can be used to anticipate potentially significant public acceptance issues.« less

Sensitivity of cell-based biosensors to environmental variables.

PubMed

Gilchrist, Kristin H; Giovangrandi, Laurent; Whittington, R Hollis; Kovacs, Gregory T A

2005-01-15

Electrically active living cells cultured on extracellular electrode arrays are utilized to detect biologically active agents. Because cells are highly sensitive to environmental conditions, environmental fluctuations can elicit cellular responses that contribute to the noise in a cell-based biosensor system. Therefore, the characterization and control of environmental factors such as temperature, pH, and osmolarity is critical in such a system. The cell-based biosensor platform described here utilizes the measurement of action potentials from cardiac cells cultured on electrode arrays. A recirculating fluid flow system is presented for use in dose-response experiments that regulates temperature within +/-0.2 degrees C, pH to within +/-0.05 units, and allows no significant change in osmolarity. Using this system, the relationship between the sensor output parameters and environmental variation was quantified. Under typical experimental conditions, beat rate varied approximately 10% per degree change in temperature or per 0.1 unit change in pH. Similar relationships were measured for action potential amplitude, duration, and conduction velocity. For the specific flow system used in this work, the measured environmental sensitivity resulted in an overall beat rate variation of +/-4.7% and an overall amplitude variation of +/-3.3%. The magnitude of the noise due to environmental sensitivity has a large impact on the detection capability of the cell-based system. The significant responses to temperature, pH, and osmolarity have important implications for the use of living cells in detection systems and should be considered in the design and evaluation of such systems.

Bioelectric potentials in the soil-plant system

NASA Astrophysics Data System (ADS)

Pozdnyakov, A. I.

2013-07-01

A detailed study of the electric potentials in the soil-plant system was performed. It was found that the electric potential depends on the plant species and the soil properties. A theoretical interpretation of the obtained data was given. All the plants, independently from their species and their state, always had a negative electric potential relative to the soil. The electric potential of the herbaceous plants largely depended on the leaf area. In some plants, such as burdock ( Arctium lappa) and hogweed ( Heracleum sosnowskyi), the absolute values of the negative electric potential exceeded 100 mV. The electric potential was clearly differentiated by the plant organs: in the flowers, it was lower than in the leaves; in the leaves, it was usually lower than in the leaf rosettes and stems. The electric potentials displayed seasonal dynamics. As a rule, the higher the soil water content, the lower the electric potential of the plants. However, an inverse relationship was observed for dandelions ( Taraxacum officinale). It can be supposed that the electric potential between the soil and the plant characterizes the vital energy of the plant.

Seasonal differences in relationships between nitrate concentration and denitrification rates in ditch sediments vegetated with rice cutgrass (Leersia oryzoides)

USDA-ARS?s Scientific Manuscript database

Increased application of nitrogen (N) fertilizers in agricultural systems contributes to significant environmental impacts, including eutrophication of fresh and coastal waters. Rice cutgrass (Leersia oryzoides) can significantly enhance denitrification potential in agricultural ditch sediments and ...

Current understanding of the relationship between periodontal and systemic diseases

PubMed Central

Mawardi, Hani H.; Elbadawi, Lena S.; Sonis, Stephen T.

2015-01-01

Periodontal disease (PD) is among the most common infectious diseases affecting humans. While the burden of periodontal disease on oral health has been extensively investigated, a possible specific relationship between the disease and systemic health is a relatively new area of interest. More recently it has been suggested that PD has an etiological role in the development of atherosclerotic cardiovascular disease, diabetes mellitus, and preterm low-birth weight, among others. In this review, we critically evaluate the current knowledge on the relation between PD and systemic diseases overall, and specifically with cardiovascular diseases. The best available evidence today suggests that the infection and inflammatory reaction associated with PD may contribute toward systemic disease. It is critical that dentists and physicians are well informed of the potential general health impact of periodontal disease so that they are in a position to knowledgeably counsel patients. PMID:25719577

A case study of data integration for aquatic resources using semantic web technologies

USGS Publications Warehouse

Gordon, Janice M.; Chkhenkeli, Nina; Govoni, David L.; Lightsom, Frances L.; Ostroff, Andrea C.; Schweitzer, Peter N.; Thongsavanh, Phethala; Varanka, Dalia E.; Zednik, Stephan

2015-01-01

Use cases, information modeling, and linked data techniques are Semantic Web technologies used to develop a prototype system that integrates scientific observations from four independent USGS and cooperator data systems. The techniques were tested with a use case goal of creating a data set for use in exploring potential relationships among freshwater fish populations and environmental factors. The resulting prototype extracts data from the BioData Retrieval System, the Multistate Aquatic Resource Information System, the National Geochemical Survey, and the National Hydrography Dataset. A prototype user interface allows a scientist to select observations from these data systems and combine them into a single data set in RDF format that includes explicitly defined relationships and data definitions. The project was funded by the USGS Community for Data Integration and undertaken by the Community for Data Integration Semantic Web Working Group in order to demonstrate use of Semantic Web technologies by scientists. This allows scientists to simultaneously explore data that are available in multiple, disparate systems beyond those they traditionally have used.

Muddying the Waters: A New Area of Concern for Drinking Water Contamination in Cameroon

PubMed Central

Healy Profitós, Jessica M.; Mouhaman, Arabi; Lee, Seungjun; Garabed, Rebecca; Moritz, Mark; Piperata, Barbara; Tien, Joe; Bisesi, Michael; Lee, Jiyoung

2014-01-01

In urban Maroua, Cameroon, improved drinking water sources are available to a large majority of the population, yet this water is frequently distributed through informal distribution systems and stored in home containers (canaries), leaving it vulnerable to contamination. We assessed where contamination occurs within the distribution system, determined potential sources of environmental contamination, and investigated potential pathogens. Gastrointestinal health status (785 individuals) was collected via health surveys. Drinking water samples were collected from drinking water sources and canaries. Escherichia coli and total coliform levels were evaluated and molecular detection was performed to measure human-associated faecal marker, HF183; tetracycline-resistance gene, tetQ; Campylobacter spp.; and Staphylococcus aureus. Statistical analyses were performed to evaluate the relationship between microbial contamination and gastrointestinal illness. Canari samples had higher levels of contamination than source samples. HF183 and tetQ were detected in home and source samples. An inverse relationship was found between tetQ and E. coli. Presence of tetQ with lower E. coli levels increased the odds of reported diarrhoeal illness than E. coli levels alone. Further work is warranted to better assess the relationship between antimicrobial-resistant bacteria and other pathogens in micro-ecosystems within canaries and this relationship’s impact on drinking water quality. PMID:25464137

Local thermodynamics and the generalized Gibbs-Duhem equation in systems with long-range interactions.

PubMed

Latella, Ivan; Pérez-Madrid, Agustín

2013-10-01

The local thermodynamics of a system with long-range interactions in d dimensions is studied using the mean-field approximation. Long-range interactions are introduced through pair interaction potentials that decay as a power law in the interparticle distance. We compute the local entropy, Helmholtz free energy, and grand potential per particle in the microcanonical, canonical, and grand canonical ensembles, respectively. From the local entropy per particle we obtain the local equation of state of the system by using the condition of local thermodynamic equilibrium. This local equation of state has the form of the ideal gas equation of state, but with the density depending on the potential characterizing long-range interactions. By volume integration of the relation between the different thermodynamic potentials at the local level, we find the corresponding equation satisfied by the potentials at the global level. It is shown that the potential energy enters as a thermodynamic variable that modifies the global thermodynamic potentials. As a result, we find a generalized Gibbs-Duhem equation that relates the potential energy to the temperature, pressure, and chemical potential. For the marginal case where the power of the decaying interaction potential is equal to the dimension of the space, the usual Gibbs-Duhem equation is recovered. As examples of the application of this equation, we consider spatially uniform interaction potentials and the self-gravitating gas. We also point out a close relationship with the thermodynamics of small systems.

Mapping the Distribution of Potential Land Drought in Batam Island Using the Integration of Remote Sensing and Geographic Information Systems (GIS)

NASA Astrophysics Data System (ADS)

Lubis, M. Z.; Taki, H. M.; Anurogo, W.; Pamungkas, D. S.; Wicaksono, P.; Aprilliyanti, T.

2017-12-01

Potential land drought mapping on Batam is needed to determine the distribution of areas that are very potential to the physical drought of the land. It is because the drought is always threatening on the long dry season. This research integrates remote sensing science with Geographic Information System (GIS). This research aims to map the distribution of land drought potential in Batam Island. The parameters used in this research are land use, Land Surface Temperature (LST), Potential dryness of land on the Batam island. The resulting map indicates the existence of five potential drought classes on the island of Batam. The area of very low drought potential is 2629.45 ha, mostly located in the Sungai Beduk sub-district. High drought potential with an area of 7081.39 ha is located in Sekupang sub-district. The distribution of very high land drought potential is in Batam city and Nongsa sub-district with area of 15600.12 ha. The coefficient of determination (R 2) is 0.6279. This indicates a strong positive relationship between field LST and modelled LST.

An Econometric Analysis of the Unemployment Insurance System in a Local Urban Labor Market. Final Report for September 1, 1973--September 30, 1974.

ERIC Educational Resources Information Center

Marston, Stephen Tilney

The study derives a model of the unemployment insurance (UI) system and its relationship to the labor market, estimates it with data from the Detroit Standard Metropolitan Statistical Area, and evaluates its potential use to forecast UI benefit amounts, UI insured unemployment, and UI exhaustions. It further uses the model to analyze policy issues…

The attachment system in fledgling relationships: an activating role for attachment anxiety.

PubMed

Eastwick, Paul W; Finkel, Eli J

2008-09-01

Is it sensible to study attachment dynamics between potential romantic partners before they share a full-fledged attachment bond? The present data indicate that such an approach may reveal novel insights about initial attraction processes. Four studies suggest that the state-like experience of attachment anxiety has functional implications within fledgling (i.e., desired or undeveloped) romantic relationships, well before the formation of an attachment bond. Studies 1 and 3 reveal that attachment anxiety directed toward a particular romantic interest is elevated before (in comparison with after) participants report being in an established relationship. Studies 2 and 3 demonstrate that such partner-specific attachment anxiety predicts attachment-relevant outcomes in fledgling relationships, including proximity seeking, safe haven, secure base, passionate love, and other approach behaviors. These associations were reliable above and beyond (and were typically as strong as or stronger than) the effect of sexual desire. Finally, Study 4 presents evidence that partner-specific attachment anxiety may cause several of these attachment-relevant outcomes. Attachment anxiety seems to be a normative experience and may signal the activation of the attachment system during the earliest stages of romantic relationships.

Rotary Wing Deceleration Use on Titan

NASA Technical Reports Server (NTRS)

Young, Larry A.; Steiner, Ted J.

2011-01-01

Rotary wing decelerator (RWD) systems were compared against other methods of atmospheric deceleration and were determined to show significant potential for application to a system requiring controlled descent, low-velocity landing, and atmospheric research capability on Titan. Design space exploration and down-selection results in a system with a single rotor utilizing cyclic pitch control. Models were developed for selection of a RWD descent system for use on Titan and to determine the relationships between the key design parameters of such a system and the time of descent. The possibility of extracting power from the system during descent was also investigated.

Photovoltaics as a terrestrial energy source. Volume 2: System value

NASA Technical Reports Server (NTRS)

Smith, J. L.

1980-01-01

Assumptions and techniques employed by the electric utility industry and other electricity planners to make estimates of the future value of photovoltaic (PV) systems interconnected with U.S. electric utilities were examined. Existing estimates of PV value and their interpretation and limitations are discussed. PV value is defined as the marginal private savings accruing to potential PV owners. For utility-owned PV systems, these values are shown to be the after-tax savings in conventional fuel and capacity displaced by the PV output. For non-utility-owned (distributed) systems, the utility's savings in fuel and capacity must first be translated through the electric rate structure (prices) to the potential PV system owner. Base-case estimates of the average value of PV systems to U.S. utilities are presented. The relationship of these results to the PV Program price goals and current energy policy is discussed; the usefulness of PV output quantity goals is also reviewed.

Approaches to the study of intelligence

NASA Technical Reports Server (NTRS)

Norman, Donald A.

1991-01-01

A survey and an evaluation are conducted for the Rosenbloom et al. (1991) 'SOAR' model of intelligence, both as found in humans and in prospective AI systems, which views it as a representational system for goal-oriented symbolic activity based on a physical symbol system. Attention is given to SOAR's implications for semantic and episodic memory, symbol processing, and search within a uniform problem space; also noted are the relationships of SOAR to competing AI schemes, and its potential usefulness as a theoretical tool for cognitive psychology.

Integrated Programs: Curriculum or Pedagogy?

ERIC Educational Resources Information Center

Bowdridge, Michael

2011-01-01

Over the years, the relationship between outdoor education and public schools has been a rocky one, and as a result it can be argued that outdoor education has never gained a significant foothold in the Canadian educational system. Though some believe that a potential incompatibility exists between outdoor education and schools, it is interesting…

Predicting root biomass of burned and unburned white oak advance reproduction from diameter and height

Treesearch

Benjamin O. Knapp; G. Geoff Wang; David H. Van Lear; Joan L. Walker

2006-01-01

The size, especially the root size, of advance oak (Quercus spp.) reproduction provides the best indication of the growth potential after release or top-kill. This study examined the relationship between the size of the root system and various diameter height measurements for small (

Yield gaps and yield relationships in US soybean production systems

USDA-ARS?s Scientific Manuscript database

The magnitude of yield gaps (YG) (potential yield – farmer yield) provides some indication of the prospects for increasing crop yield to meet the food demands of future populations. Quantile regression analysis was applied to county soybean [Glycine max (L.) Merrill] yields (1971 – 2011) from Kentuc...

Dentist-technician collaboration in the digital age: enhancing outcomes through photography, teamwork, and technology.

PubMed

Schoenbaum, Todd R; Chang, Yi-Yuan

2011-08-01

The cornerstone of a strong and successful dentist-technician relationship is communication. High-level collaboration across distances requires modern technology to communicate expectations, potential outcomes, and limitations. Carefully calibrated digital photography is an essential element in this inherently artistic process. This ensures a system of checks and balances to minimize the potential for miscommunication and remakes. Forthcoming technologies will allow dentist-technician teams to reach ever-greater levels of collaboration.

NASA Enterprise Architecture and Its Use in Transition of Research Results to Operations

NASA Astrophysics Data System (ADS)

Frisbie, T. E.; Hall, C. M.

2006-12-01

Enterprise architecture describes the design of the components of an enterprise, their relationships and how they support the objectives of that enterprise. NASA Stennis Space Center leads several projects involving enterprise architecture tools used to gather information on research assets within NASA's Earth Science Division. In the near future, enterprise architecture tools will link and display the relevant requirements, parameters, observatories, models, decision systems, and benefit/impact information relationships and map to the Federal Enterprise Architecture Reference Models. Components configured within the enterprise architecture serving the NASA Applied Sciences Program include the Earth Science Components Knowledge Base, the Systems Components database, and the Earth Science Architecture Tool. The Earth Science Components Knowledge Base systematically catalogues NASA missions, sensors, models, data products, model products, and network partners appropriate for consideration in NASA Earth Science applications projects. The Systems Components database is a centralized information warehouse of NASA's Earth Science research assets and a critical first link in the implementation of enterprise architecture. The Earth Science Architecture Tool is used to analyze potential NASA candidate systems that may be beneficial to decision-making capabilities of other Federal agencies. Use of the current configuration of NASA enterprise architecture (the Earth Science Components Knowledge Base, the Systems Components database, and the Earth Science Architecture Tool) has far exceeded its original intent and has tremendous potential for the transition of research results to operational entities.

Crowd Sensing-Enabling Security Service Recommendation for Social Fog Computing Systems

PubMed Central

Wu, Jun; Su, Zhou; Li, Jianhua

2017-01-01

Fog computing, shifting intelligence and resources from the remote cloud to edge networks, has the potential of providing low-latency for the communication from sensing data sources to users. For the objects from the Internet of Things (IoT) to the cloud, it is a new trend that the objects establish social-like relationships with each other, which efficiently brings the benefits of developed sociality to a complex environment. As fog service become more sophisticated, it will become more convenient for fog users to share their own services, resources, and data via social networks. Meanwhile, the efficient social organization can enable more flexible, secure, and collaborative networking. Aforementioned advantages make the social network a potential architecture for fog computing systems. In this paper, we design an architecture for social fog computing, in which the services of fog are provisioned based on “friend” relationships. To the best of our knowledge, this is the first attempt at an organized fog computing system-based social model. Meanwhile, social networking enhances the complexity and security risks of fog computing services, creating difficulties of security service recommendations in social fog computing. To address this, we propose a novel crowd sensing-enabling security service provisioning method to recommend security services accurately in social fog computing systems. Simulation results show the feasibilities and efficiency of the crowd sensing-enabling security service recommendation method for social fog computing systems. PMID:28758943

Crowd Sensing-Enabling Security Service Recommendation for Social Fog Computing Systems.

PubMed

Wu, Jun; Su, Zhou; Wang, Shen; Li, Jianhua

2017-07-30

Fog computing, shifting intelligence and resources from the remote cloud to edge networks, has the potential of providing low-latency for the communication from sensing data sources to users. For the objects from the Internet of Things (IoT) to the cloud, it is a new trend that the objects establish social-like relationships with each other, which efficiently brings the benefits of developed sociality to a complex environment. As fog service become more sophisticated, it will become more convenient for fog users to share their own services, resources, and data via social networks. Meanwhile, the efficient social organization can enable more flexible, secure, and collaborative networking. Aforementioned advantages make the social network a potential architecture for fog computing systems. In this paper, we design an architecture for social fog computing, in which the services of fog are provisioned based on "friend" relationships. To the best of our knowledge, this is the first attempt at an organized fog computing system-based social model. Meanwhile, social networking enhances the complexity and security risks of fog computing services, creating difficulties of security service recommendations in social fog computing. To address this, we propose a novel crowd sensing-enabling security service provisioning method to recommend security services accurately in social fog computing systems. Simulation results show the feasibilities and efficiency of the crowd sensing-enabling security service recommendation method for social fog computing systems.

A Study of the Relationship between Weather Variables and Electric Power Demand inside a Smart Grid/Smart World Framework

PubMed Central

Hernández, Luis; Baladrón, Carlos; Aguiar, Javier M.; Calavia, Lorena; Carro, Belén; Sánchez-Esguevillas, Antonio; Cook, Diane J.; Chinarro, David; Gómez, Jorge

2012-01-01

One of the main challenges of today's society is the need to fulfill at the same time the two sides of the dichotomy between the growing energy demand and the need to look after the environment. Smart Grids are one of the answers: intelligent energy grids which retrieve data about the environment through extensive sensor networks and react accordingly to optimize resource consumption. In order to do this, the Smart Grids need to understand the existing relationship between energy demand and a set of relevant climatic variables. All smart “systems” (buildings, cities, homes, consumers, etc.) have the potential to employ their intelligence for self-adaptation to climate conditions. After introducing the Smart World, a global framework for the collaboration of these smart systems, this paper presents the relationship found at experimental level between a range of relevant weather variables and electric power demand patterns, presenting a case study using an agent-based system, and emphasizing the need to consider this relationship in certain Smart World (and specifically Smart Grid and microgrid) applications.

Spikes, Local Field Potentials, and Electrocorticogram Characterization during Motor Learning in Rats for Brain Machine Interface Tasks.

PubMed

Marzullo, T C; Dudley, J R; Miller, C R; Trejo, L; Kipke, D R

2005-01-01

Brain machine interface development typically falls into two arenas, invasive extracellular recording and non-invasive electroencephalogram recording methods. The relationship between action potentials and field potentials is not well understood, and investigation of interrelationships may improve design of neuroprosthetic control systems. Rats were trained on a motor learning task whereby they had to insert their noses into an aperture while simultaneously pressing down on levers with their forepaws; spikes, local field potentials (LFPs), and electrocorticograms (ECoGs) over the motor cortex were recorded and characterized. Preliminary results suggest that the LFP activity in lower cortical layers oscillates with the ECoG.

Multi-tiered system of support incorporating the R.E.N.E.W. process and its relationship to perception of school safety and office discipline referrals

NASA Astrophysics Data System (ADS)

Flood, Molly M.

This study examined the relationship between the fidelity of multi-tier school-wide positive behavior interventions and supports (SWPBIS) and staff perception of school safety and office discipline referrals. This research provided a case study on multi-tier supports and interventions, and the RENEW person-centered planning process in an alternative special education center following the implementation of a multi-tier SWPBIS model. Pennsylvania is one of several states looking to adopt an effective Tier III behavioral tool. The research described the results of an analysis of implementation fidelity on a multi-tiered school-wide positive behavior support model developed at a special education center operated by a public school system entity. This research explored the fidelity of SWPBIS implementation; analyzed the relationship of SWPBIS to school climate as measured by staff perceptions and reduction of office discipline referrals (ODR); explored tier III supports incorporating a process Rehabilitation and Empowerment, Natural Supports, Education and Work (RENEW); and investigated the potential sustainability of the RENEW process as a multi-tier system of support. This study investigated staff perceptions on integrated supports between schools and communities and identified the degree of relationship to school risk factors, school protective factors, and office discipline referrals following the building of cooperative partnerships between Systems of Care and Local Education Agencies.

Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides

PubMed Central

Enman, Nicole M.; Zhang, Yong; Unterwald, Ellen M.

2014-01-01

Posttraumatic stress disorder (PTSD) co-occurs highly with substance use disorders (SUD), yet the neurobiological basis for this comorbid relationship remains unclear. PTSD and SUDs result in similar pathological states including impulsive behavior, reward deficiency, and heightened stress sensitivity. Hence, PTSD and SUD may depend on overlapping dysfunctional neurocircuitry. Here we provide a short overview of the relationship between comorbid PTSD and SUD, as well as the potential role of select neurotransmitter systems that may underlie enhanced vulnerability to drug abuse in the context of PTSD. PMID:24333548

Leadership development practices and hospital financial outcomes.

PubMed

Crowe, Daniel; Garman, Andrew N; Li, Chien-Ching; Helton, Jeff; Anderson, Matthew M; Butler, Peter

2017-08-01

Affordable Care Act legislation is requiring leaders in US health systems to adapt to new and very different approaches to improving operating performance. Research from other industries suggests leadership development can be a helpful component of organizational change strategies; however, there is currently very little healthcare-specific research available to guide design and deployment. The goal of this exploratory study is to examine potential relationships between specific leadership development practices and health system financial outcomes. Results from the National Center for Healthcare Leadership survey of leadership development practices were correlated with hospital and health system financial performance data from the 2013 Medicare Cost Reports. A general linear regression model, controlling for payer mix, case-mix index, and bed size, was used to assess possible relationships between leadership practices and three financial performance metrics: operating margin, days cash on hand, and debt to capitalization. Statistically significant associations were found between hospital-level operating margins and 5 of the 11 leadership practices as well as the composite score. Relationships at the health system level, however, were not statistically significant. Results provide preliminary evidence of an association between hospital financial performance and investments made in developing their leaders.

Do extra-group fertilizations increase the potential for sexual selection in male mammals?

PubMed

Isvaran, Kavita; Sankaran, Sumithra

2017-10-01

Fertilizations by males outside the social breeding group (extra-group paternity, EGP) are widespread in birds and mammals. EGP is generally proposed to increase male reproductive skew and thereby increase the potential for sexual selection, but the generality of this relationship is unclear. We extracted data from 27 mammals in seven orders and used phylogenetic comparative methods to investigate the influence of EGP and social mating system on measures of inequality in male fertilization success, which are indices of the potential for sexual selection. We find that EGP and social mating system can predict the potential for sexual selection in mammalian populations, but only when considered jointly and not individually. EGP appears to increase the potential for sexual selection but only when the degree of social polygyny is relatively low. When social polygyny is high, EGP appears to result in a more uniform distribution of reproduction and a decrease in the potential for sexual selection. A possible explanation to be investigated is that the phenotype of extra-group fathers differs systematically across social mating systems. Our findings have implications for the use of EGP and social mating system as indices of sexual selection in comparative analyses of trait evolution under sexual selection. © 2017 The Author(s).

Does the organizational structure of health care systems influence care-seeking decisions? A qualitative analysis of Danish cancer patients' reflections on care-seeking

PubMed Central

Andersen, Rikke Sand; Vedsted, Peter; Olesen, Frede; Bro, Flemming; Søndergaard, Jens

2011-01-01

Objective The absence of a more significant improvement in cancer survival in countries such as the UK and Denmark may be partly rooted in delayed care-seeking among cancer patients. Past research on patient delay has mainly focused on patient characteristics (e.g. sociodemographic and psychological factors and symptom recognition) as causes of delayed care-seeking, while few studies have examined how the organizational structure of health care systems may influence patients’ reflections on seeking care. The aim of this study was to explore this relationship. Design The analysis presented is based on semi-structured interviews with 30 cancer patients and their families. Results The article raises two hypotheses on the relationship between structural elements of a health care system and people's reflections on seeking health care: (1) Gatekeeping introduces an asymmetrical relationship between the patient and the GP which potentially results in self-restricting care-seeking, (2) Continuity in the doctor–patient relationship may negatively influence patient reflections on access to health care, as the focus shifts from the medical issues of the consultation to reflections on how to properly interact with the GP and the system in which she/he is situated. Conclusion It is concluded that these hypotheses form a sound basis for further primary care research on how the organizational structure of health care systems influences patient reflections on access to medical care. PMID:21861597

Self-efficacy as a mediator of the relationship between social support and recovery in serious mental illness.

PubMed

Thomas, Elizabeth C; Muralidharan, Anjana; Medoff, Deborah; Drapalski, Amy L

2016-12-01

The purposes of this research were to assess relationships between social support and objective and subjective recovery in a sample of adults with serious mental illness and to examine self-efficacy as a potential mediator of these relationships. In this cross-sectional study, a sample of 250 individuals completed measures tapping social support network size, satisfaction with social support, perceived support from the mental health system, self-efficacy, objective recovery (i.e., psychiatric symptoms, social functioning), and subjective recovery. Pearson product-moment correlations and multiple linear regression analyses examined relationships among social support, self-efficacy, and recovery. A bootstrapping procedure was used to estimate the magnitude and significance of indirect effects in mediation analyses. All social support domains (i.e., social support network size, satisfaction with support, perceived support from the mental health system) were significantly related to at least 1 objective recovery outcome and to subjective recovery. Self-efficacy was a mediator of all relationships between social support and objective and subjective recovery. The present study aids in better understanding the relationship between social support and recovery in individuals with serious mental illness and paves the way for future research. Particularly relevant to mental health service providers, it highlights the importance of establishing and maintaining an effective therapeutic relationship as well as assisting consumers with developing supportive relationships with others. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The Relationship between Chlorophyll Fluorescence Parameter (Fv/Fm) and Frequency Component of Plant Bioelectric Potential in Spraying Chemical Herbicides

NASA Astrophysics Data System (ADS)

Shibata, Shin-Ichi; Satou, Fumitake; Kimura, Haruhiko; Oyabu, Takashi

Recently, there is a problem of the steady supply of food therefore plant factory has been establishing and takes off in world wide countries. In the plant factory, the growing environment can be controlled and the crop can also be controlled. The products are growing in an enclosed environment, therefore agricultural chemicals has no use. Secure and safe food producing system can be constructed. However, efficient production formula for the plant (for example vegetable) is not defined well. It is an effective way to control the growing environmental factors using physiology information which are directly obtained from the vegetable. The chlorophyll fluorescence is used as evaluation of plant condition. It is necessary to clarify the bioelectric potential in the growth condition of the plant. In this study, we examined the relationship between the chlorophyll fluorescence and the plant bioelectric potential in bad condition. The plant in spraying chemical herbicides was assumed as the condition. In future, plant physiological function and environmental response can be understood by directly monitoring the bioelectric potential.

Ozone Sensitivity in Sweet Corn (Zea mays L.) Plants: A Possible Relationship to Water Balance

PubMed Central

Harris, Michael J.; Heath, Robert L.

1981-01-01

Stomatal characteristics affecting gas exchange were compared in two sweet corn hybrids (var. Bonanza and Monarch Advance) which differ in foliar ozone sensitivity. No significant differences were observed in stomatal frequencies, guard cell lengths, or conductances to water vapor diffusion. When plant water status was compared, leaf-water potentials for the ozone-resistant cultivar, Bonanza, were lower. A comparison of the relationship between soil- and leaf-water potential indicated that the leaf-water potential of Bonanza was more sensitive to declines in soil-water potential. Additionally, a comparison of stomatal conductance to water vapor diffusion as soil moisture declined and following root detachment indicated that stomata of Bonanza were, likewise, more sensitive to increasing water stress. Data suggest that these differences are attributable to a greater shoot-to-root fresh weight ratio and higher resistance to water movement in the water-conducting tissues for Bonanza. Our observations suggest that root and water delivery system characteristics play a major contributory role in the determination of foliar ozone sensitivity in this species. PMID:16662019

Are Characteristics of the Medical Home Associated with Diabetes Care Costs?

PubMed Central

Flottemesch, Thomas J.; Scholle, Sarah Hudson; O’Connor, Patrick J.; Solberg, Leif I.; Asche, Steve; Pawlson, L. Gregory

2015-01-01

Objective To examine the relationship between primary care medical home clinical practice systems (PCMH clinical practice systems) corresponding to the domains of the Chronic Care Model and diabetes-related healthcare costs incurred by members of a health plan who have diagnosed Type 2 diabetes and received care at one of 27 Minnesota-based medical groups over a 12-month period. Study Design Cross-sectional analysis of patient-level cost data in relation to the presence of PCMH clinical practice systems by Chronic Care Model domain using the Physician Practice Connections Readiness Survey (PPC-RS). Methods Multivariate regressions adjusting for patient demographics, health status and comorbidities estimated the relationship between the presence of PCMH clinical practice systems as measured by the PPC-RS and three outcomes: total diabetes-related healthcare costs, ambulatory care management costs, and potentially avoidable costs (e.g. unscheduled inpatient and emergency care). Results Two domains of PCMH clinical practice systems as measured by the PPC-RS were significantly associated with reductions in potentially avoidable costs. These were Health Care Organization (p=.04) and clinical reminder systems in the Decision Support domain (p=.01). Compared to medical groups with only quality improvement, those with improved Health Care Organization defined as performance measurement and individual provider feedback averaged $245/patient less. Similarly, medical groups with clinical reminders for counseling averaged $338/patient less. Conclusions PCMH clinical practice systems that correspond to some domains of the Chronic Care Model are related to reduced inpatient and emergency care costs. Further research is needed about how these systems impact costs over time. PMID:22710277

Consumer-operated service organizations: organizational characteristics, community relationships, and the potential for citizenship.

PubMed

Tanenbaum, Sandra J

2012-08-01

Consumer-operated service organizations (COSOs) are independent organizations whose administrative and financial control resides with consumers. Based on a 2008 mail survey and followup interviews conducted in 2009, this study depicts the internal characteristics and external relationships, as well as some relationships between the two, of COSOs in one state. Profiles include on the one hand, governance structures, services provided, sources and levels of funding, etc. and on the other, relationships between COSOs and other actors in the mental health system and the local community. COSOs emerge as more self-governing and community-based than required by certification requirements and as developing internally and externally in tandem. COSOs are not only adjunct or alternative service providers, but also civic associations and loci for the expression of citizenship by mentally ill people.

Relationships among clinical measures of periodontal disease and their associations with systemic markers.

PubMed

Beck, James D; Offenbacher, Steven

2002-12-01

Recent investigations of the relationship between periodontitis and systemic disease require that periodontal disease also must be thought of as a disease process that is an exposure for a systemic disease or condition (outcome), rather than as the outcome itself. When viewing periodontal disease as an exposure, investigators must consider the clinical, microbiological, and inflammatory components of periodontitis that potentially convey risk for the systemic outcome of interest, which may or may not be the same as those associated with the assessments used to define tooth-based disease. Another important consideration is the temporal relationship between the exposure and the outcome of interest. To explore which definitions of periodontal disease or clustering of clinical signs are important with regards to systemic exposure to inflammatory stress, we examined the relationship between clinical periodontal disease measures and 2 systemic inflammatory markers of increased risk for cardiovascular disease: serum soluble intercellular adhesion molecule (sICAM), which is a measure of vascular stress and serum C-reactive protein (CRP), which is a measure of hepatic acute-phase response. The Dental Arteriosclerosis Risk in Communities (ARIC) study, a cross-sectional study of the relationship between periodontal disease and cardiovascular disease, forms the basis for the examples used in this investigation. Our findings demonstrated that while attachment loss, probing depth, (PD) and bleeding on probing (BOP) are individually associated with sICAM and CRP, only BOP remains significant for sICAM when all 3 are in the model and, for CRP, only PD remains significant. Both of these clinical parameters were more robust in estimating the degree of systemic inflammation than traditional classifications of mild, moderate, and severe periodontitis or other measures of disease severity such as attachment loss. When selecting a definition of "systemic periodontitis" (periodontal disease that represents an exposure for a systemic condition), it is helpful to think of periodontal disease as a chronic oral infection with a number of clinical signs, rather than as the dento-centrically defined entity, periodontal disease. Thus, "systemic periodontitis" should be defined predicated upon those clinical signs that best represent the underlying mechanisms and temporal sequence that may affect that systemic outcome.

The ISO Edi Conceptual Model Activity and Its Relationship to OSI.

ERIC Educational Resources Information Center

Fincher, Judith A.

1990-01-01

The edi conceptual model is being developed to define common structures, services, and processes that syntax-specific standards like X12 and EDIFACT could adopt. Open Systems Interconnection (OSI) is of interest to edi because of its potential to help enable global interoperability across Electronic Data Interchange (EDI) functional groups. A…

Relationship between School-Wide Positive Behavior Interventions and Supports and Academic, Attendance, and Behavior Outcomes in High Schools

ERIC Educational Resources Information Center

Freeman, Jennifer; Simonsen, Brandi; McCoach, D. Betsy; Sugai, George; Lombardi, Allison; Horner, Robert

2016-01-01

Attendance, behavior, and academic outcomes are important indicators of school effectiveness and long-term student outcomes. "Multi-tiered systems of support" (MTSS), such as "School-Wide Positive Behavior Interventions and Supports" (SWPBIS), have emerged as potentially effective frameworks for addressing student needs and…

Communication Deficits and the Motor System: Exploring Patterns of Associations in Autism Spectrum Disorder (ASD)

ERIC Educational Resources Information Center

Mody, M.; Shui, A. M.; Nowinski, L. A.; Golas, S. B.; Ferrone, C.; O'Rourke, J. A.; McDougle, C. J.

2017-01-01

Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and…

"I Wish I Had a Crystal Ball": Discourses and Potentials for Developing Academic Supervising

ERIC Educational Resources Information Center

Vehviläinen, Sanna; Löfström, Erika

2016-01-01

Academic supervision of PhD dissertations and master's theses has traditionally been conceptualised as the pedagogy of the dyadic relationship between master and apprentice. Recently, researchers have argued for a more systemic approach. Yet, many communities lack practices for sharing the pedagogical responsibility of supervision. Consequently,…

SYSTEMIC VASCULAR DISEASE IN MALE B6C3F1 MICE EXPOSED TO PARTICULATE MATTER BY INHALATION: STUDIES CONDUCTED BY THE NATIONAL TOXICOLOGY PROGRAM

EPA Science Inventory

Abstract

Epidemiological studies suggest an association between ambient particulate matter and cardiopulmonary diseases in humans. The mechanisms underlying these health effects are poorly understood. To better understand the potential relationship between particulate-ma...

Diverse applications of advanced man-telerobot interfaces

NASA Technical Reports Server (NTRS)

Mcaffee, Douglas A.

1991-01-01

Advancements in man-machine interfaces and control technologies used in space telerobotics and teleoperators have potential application wherever human operators need to manipulate multi-dimensional spatial relationships. Bilateral six degree-of-freedom position and force cues exchanged between the user and a complex system can broaden and improve the effectiveness of several diverse man-machine interfaces.

Granuloma Transplantation: An Approach to Study Mycobacterium–Host Interactions

PubMed Central

Harding, Jeffrey S.; Schreiber, Heidi A.; Sandor, Matyas

2011-01-01

The host–pathogen biology during infection with Mycobacterium tuberculosis is incredibly complex and despite accelerating progress in research, remains poorly understood. Our limited understanding hinders the development of new drugs, next generation vaccines, and novel therapies. The granuloma is the site where mycobacteria are both controlled and allowed to persist, but it remains one of the least studied aspects of the host–pathogen relationship. Here, we review the development, application, potential uses, and limitations of a novel model of granuloma transplantation as a tool to study specific host–pathogen interactions that have been difficult to probe. Application of this new model has already contributed to our understanding of granuloma cell traffic, repopulation, and the relationship between systemic immunity and mycobacteria-containing granulomas. The data collected highlight the dynamic interaction between systemic and local immune processes and support a paradigm that defines the granuloma as a highly dynamic structure. Granuloma transplantation also has special potential as a novel latency model that can contribute to our understanding of host protection factors and bacterial mutants, and serve as a platform for drug testing. PMID:22180751

Identifying and Evaluating the Relationships that Control a Land Surface Model's Hydrological Behavior

NASA Technical Reports Server (NTRS)

Koster, Randal D.; Mahanama, Sarith P.

2012-01-01

The inherent soil moisture-evaporation relationships used in today 's land surface models (LSMs) arguably reflect a lot of guesswork given the lack of contemporaneous evaporation and soil moisture observations at the spatial scales represented by regional and global models. The inherent soil moisture-runoff relationships used in the LSMs are also of uncertain accuracy. Evaluating these relationships is difficult but crucial given that they have a major impact on how the land component contributes to hydrological and meteorological variability within the climate system. The relationships, it turns out, can be examined efficiently and effectively with a simple water balance model framework. The simple water balance model, driven with multi-decadal observations covering the conterminous United States, shows how different prescribed relationships lead to different manifestations of hydrological variability, some of which can be compared directly to observations. Through the testing of a wide suite of relationships, the simple model provides estimates for the underlying relationships that operate in nature and that should be operating in LSMs. We examine the relationships currently used in a number of different LSMs in the context of the simple water balance model results and make recommendations for potential first-order improvements to these LSMs.

Towards an analytical theory of social change: the case of China.

PubMed

Liu, Serena

2006-09-01

Lockwood argues that contradiction between the core institutional order and the material substructure of a society gives rise to potential social relationships which constitute a threat to the existing institutional order and may lead to change in the type of the society. Parkin, in particular, has advocated the application of the idea to the study of socialist societies. However, the situation of socialist China opposes Lockwood's view in that the new social relationships arising from the changing economic system do not pose a threat to the existing political system. Moreover, Lockwood underdevelops the connection between human action and social structure and does not theorize the mechanism linking system weakness and social change. This article formulates an alternative perspective by building on Giddens's structuration theory and Mouzelis's work on sociological theory. The theoretical framework is applied to China to give a flavour of how social change can be studied.

Why Social Relationships Are Important for Physical Health: A Systems Approach to Understanding and Modifying Risk and Protection.

PubMed

Holt-Lunstad, Julianne

2018-01-04

Social relationships are adaptive and crucial for survival. This review presents existing evidence indicating that our social connections to others have powerful influences on health and longevity and that lacking social connection qualifies as a risk factor for premature mortality. A systems perspective is presented as a framework by which to move social connection into the realm of public health. Individuals, and health-relevant biological processes, exist within larger social contexts including the family, neighborhood and community, and society and culture. Applying the social ecological model, this review highlights the interrelationships of individuals within groups in terms of understanding both the causal mechanisms by which social connection influences physical health and the ways in which this influence can inform potential intervention strategies. A systems approach also helps identify gaps in our current understanding that may guide future research.

Climate and dengue transmission: evidence and implications.

PubMed

Morin, Cory W; Comrie, Andrew C; Ernst, Kacey

2013-01-01

Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledge of these relationships and predict the effects of projected climate change on dengue fever occurrence, but results have been inconsistent. We sought to identify major climatic influences on dengue virus ecology and to evaluate the ability of climate-based dengue models to describe associations between climate and dengue, simulate outbreaks, and project the impacts of climate change. We reviewed the evidence for direct and indirect relationships between climate and dengue generated from laboratory studies, field studies, and statistical analyses of associations between vectors, dengue fever incidence, and climate conditions. We assessed the potential contribution of climate-driven, process-based dengue models and provide suggestions to improve their performance. Relationships between climate variables and factors that influence dengue transmission are complex. A climate variable may increase dengue transmission potential through one aspect of the system while simultaneously decreasing transmission potential through another. This complexity may at least partly explain inconsistencies in statistical associations between dengue and climate. Process-based models can account for the complex dynamics but often omit important aspects of dengue ecology, notably virus development and host-species interactions. Synthesizing and applying current knowledge of climatic effects on all aspects of dengue virus ecology will help direct future research and enable better projections of climate change effects on dengue incidence.

Climate change impacts on human exposures to air pollution ...

EPA Pesticide Factsheets

This is an abstract for a presentations at the Annual Conference of the International Society on Exposure Science and Environmental Epidemiology. This presentation will serve as an introduction to the symposium. As we consider the potential health impacts of a warming planet, the relationships between climate change and air pollutants become increasingly important to understand. These relationships are complex and highly variable, causing a variety of environmental impacts at local, regional and global scales. Human exposures and health impacts for air pollutants have the potential to be altered by changes in climate through multiple factors that drive population exposures to these pollutants. Research on this topic will provide both state and local governments with the tools and scientific knowledge base to undertake any necessary adaptation of the air pollution regulations and/or public health management systems in the face of climate change.

Sex Unleashes Your Tongue: Sexual Priming Motivates Self-Disclosure to a New Acquaintance and Interest in Future Interactions.

PubMed

Birnbaum, Gurit E; Mizrahi, Moran; Kaplan, Ayelet; Kadosh, Danielle; Kariv, Dana; Tabib, Danielle; Ziv, Daniella; Sadeh, Lihi; Burban, Daniella

2017-05-01

Research has demonstrated the contribution of sexual activity to the quality of ongoing relationships. Nevertheless, less attention has been given to how activation of the sexual system affects relationship-initiation processes. Three studies used complementary methodologies to examine the effect of sexual priming on self-disclosure, a relationship-promoting behavior. In Study 1, participants were subliminally exposed to sexual stimuli (vs. neutral stimuli), and then disclosed over Instant Messenger a personal event to an opposite-sex stranger. Results showed that merely thinking about sex, even without being aware of it, encouraged self-disclosure. Study 2 replicated these findings in relatively naturalistic conditions (live face-to-face interactions following supraliminal video priming). Study 3 extended these findings, indicating that sexual priming facilitated self-disclosure, which, in turn, increased interest in future interactions with the stranger. Together, these findings suggest that activation of the sexual system encourages the use of strategies that allow people to become closer to potential partners.

Suing the doctor: lawsuits by injured workers against the occupational physician.

PubMed

Postol, L P

1989-11-01

Occupational physicians are beginning to learn that they, like other physicians, can be targets for lawsuits. This article attempts to outline the relationship between the workers' compensation system and occupational physicians' personal liability. Consideration is given to potential liability due to malpractice, negligent interference with a workers' contractual relationship with his or her employer, libel and slander, and unauthorized release of information. The requirements of the Occupational Health and Safety Administration for medical examinations and recordkeeping are also highlighted. Finally, the need to clarify the relationship between the doctor, patient/worker, and employer is analyzed. Once the occupational physician recognizes the areas for liability, he or she can take practical steps to minimize his or her exposure.

Simulation studies for surfaces and materials strength

NASA Technical Reports Server (NTRS)

Halicioglu, Timur

1987-01-01

A realistic potential energy function comprising angle dependent terms was employed to describe the potential surface of the N+O2 system. The potential energy parameters were obtained from high level ab-initio results using a nonlinear fitting procedure. It was shown that the potential function is able to reproduce a large number of points on the potential surface with a small rms deviation. A literature survey was conducted to analyze exclusively the status of current small cluster research. This survey turned out to be quite useful in understanding and finding out the existing relationship between theoretical as well as experimental investigative techniques employed by different researchers. Additionally, the importance of the role played by computer simulation in small cluster research, was documented.

Titanium is not "the most biocompatible metal" under cathodic potential: The relationship between voltage and MC3T3 preosteoblast behavior on electrically polarized cpTi surfaces.

PubMed

Ehrensberger, Mark T; Sivan, Shiril; Gilbert, Jeremy L

2010-06-15

An electrochemically controlled system has been developed which allows for cell culture directly on electrically polarized metal surfaces with simultaneous control and assessment of the electrochemical current, potential, and impedance of the interface. This system was utilized in this study to assess the interactions between electrochemically polarized commercially pure titanium (cpTi) and MC3T3 preosteoblast cells. Cells were cultured on CpTi for 24 h at static potentials between -1000 mV and +1000 mV vs. Ag/AgCl and cell morphology (SEM and cell area) and viability (MTT and Live-Dead assay) were assessed along with the electrochemical current densities and surface oxide impedance properties. The results indicate that cathodic polarization in the range of -600 mV to -1000 mV markedly reduces the spreading and viability of cells cultured directly on cpTi within 24 h, while anodic polarization (-300 mV to +1000 mV) out to 72 h shows no difference in cell behavior as compared to the OCP condition. Analysis of the relationship between the cell outcomes and the electrochemical current densities and impedance indicated the presence of voltage-dependent electrochemical thresholds (cathodic current density, i(c) > 1.0 microA/cm(2), R(p) < 10(5) Omega cm(2)) which may control the biocompatibility of cpTi. In addition, these outcomes have direct clinical significance for modular orthopedic implants whose potential can shift, via fretting corrosion, down into the range of potentials exhibiting poor cell behavior. (c) 2009 Wiley Periodicals, Inc.

A geovisual analytic approach to understanding geo-social relationships in the international trade network.

PubMed

Luo, Wei; Yin, Peifeng; Di, Qian; Hardisty, Frank; MacEachren, Alan M

2014-01-01

The world has become a complex set of geo-social systems interconnected by networks, including transportation networks, telecommunications, and the internet. Understanding the interactions between spatial and social relationships within such geo-social systems is a challenge. This research aims to address this challenge through the framework of geovisual analytics. We present the GeoSocialApp which implements traditional network analysis methods in the context of explicitly spatial and social representations. We then apply it to an exploration of international trade networks in terms of the complex interactions between spatial and social relationships. This exploration using the GeoSocialApp helps us develop a two-part hypothesis: international trade network clusters with structural equivalence are strongly 'balkanized' (fragmented) according to the geography of trading partners, and the geographical distance weighted by population within each network cluster has a positive relationship with the development level of countries. In addition to demonstrating the potential of visual analytics to provide insight concerning complex geo-social relationships at a global scale, the research also addresses the challenge of validating insights derived through interactive geovisual analytics. We develop two indicators to quantify the observed patterns, and then use a Monte-Carlo approach to support the hypothesis developed above.

A Geovisual Analytic Approach to Understanding Geo-Social Relationships in the International Trade Network

PubMed Central

Luo, Wei; Yin, Peifeng; Di, Qian; Hardisty, Frank; MacEachren, Alan M.

2014-01-01

The world has become a complex set of geo-social systems interconnected by networks, including transportation networks, telecommunications, and the internet. Understanding the interactions between spatial and social relationships within such geo-social systems is a challenge. This research aims to address this challenge through the framework of geovisual analytics. We present the GeoSocialApp which implements traditional network analysis methods in the context of explicitly spatial and social representations. We then apply it to an exploration of international trade networks in terms of the complex interactions between spatial and social relationships. This exploration using the GeoSocialApp helps us develop a two-part hypothesis: international trade network clusters with structural equivalence are strongly ‘balkanized’ (fragmented) according to the geography of trading partners, and the geographical distance weighted by population within each network cluster has a positive relationship with the development level of countries. In addition to demonstrating the potential of visual analytics to provide insight concerning complex geo-social relationships at a global scale, the research also addresses the challenge of validating insights derived through interactive geovisual analytics. We develop two indicators to quantify the observed patterns, and then use a Monte-Carlo approach to support the hypothesis developed above. PMID:24558409

Diagnosis and sensor validation through knowledge of structure and function

NASA Technical Reports Server (NTRS)

Scarl, Ethan A.; Jamieson, John R.; Delaune, Carl I.

1987-01-01

The liquid oxygen expert system 'LES' is proposed as the first capable of diagnostic reasoning from sensor data, using model-based knowledge of structure and function to find the expected state of all system objects, including sensors. The approach is generally algorithmic rather than heuristic, and represents uncertainties as sets of possibilities. Functional relationships are inverted to determine hypothetical values for potentially faulty objects, and may include conditional functions not normally considered to have inverses.

Hidden linkages between urbanization and food systems.

PubMed

Seto, Karen C; Ramankutty, Navin

2016-05-20

Global societies are becoming increasingly urban. This shift toward urban living is changing our relationship with food, including how we shop and what we buy, as well as ideas about sanitation and freshness. Achieving food security in an era of rapid urbanization will require considerably more understanding about how urban and food systems are intertwined. Here we discuss some potential understudied linkages that are ripe for further examination. Copyright © 2016, American Association for the Advancement of Science.

Quantifying the Relationship between Curvature and Electric Potential in Lipid Bilayers.

PubMed

Bruhn, Dennis S; Lomholt, Michael A; Khandelia, Himanshu

2016-06-02

Cellular membranes mediate vital cellular processes by being subject to curvature and transmembrane electrical potentials. Here we build upon the existing theory for flexoelectricity in liquid crystals to quantify the coupling between lipid bilayer curvature and membrane potentials. Using molecular dynamics simulations, we show that headgroup dipole moments, the lateral pressure profile across the bilayer, and spontaneous curvature all systematically change with increasing membrane potentials. In particular, there is a linear dependence between the bending moment (the product of bending rigidity and spontaneous curvature) and the applied membrane potentials. We show that biologically relevant membrane potentials can induce biologically relevant curvatures corresponding to radii of around 500 nm. The implications of flexoelectricity in lipid bilayers are thus likely to be of considerable consequence both in biology and in model lipid bilayer systems.

Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis.

PubMed

Borrow, A P; Stranahan, A M; Suchecki, D; Yunes, R

2016-07-01

The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are increasingly recognised for their effects on anxiety-like behaviour and reward. The present review examines recent developments related to the role of a number of different hormones in anxiety, including pregnane neurosteroids, gut peptides, neuropeptides and hormonal signals derived from fatty acids. Findings from both basic and clinical studies suggest that these alternative systems may complement or occlude stress-induced changes in anxiety and anxiety-like behaviour. By broadening the scope of mechanisms for depression and anxiety, it may be possible to develop novel strategies to attenuate stress-related psychiatric conditions. The targets for these potential therapies, as discussed in this review, encompass multiple circuits and systems, including those outside of the HPA axis. © 2016 British Society for Neuroendocrinology.

Resolving Evolutionary Relationships in Closely Related Species with Whole-Genome Sequencing Data

PubMed Central

Nater, Alexander; Burri, Reto; Kawakami, Takeshi; Smeds, Linnéa; Ellegren, Hans

2015-01-01

Using genetic data to resolve the evolutionary relationships of species is of major interest in evolutionary and systematic biology. However, reconstructing the sequence of speciation events, the so-called species tree, in closely related and potentially hybridizing species is very challenging. Processes such as incomplete lineage sorting and interspecific gene flow result in local gene genealogies that differ in their topology from the species tree, and analyses of few loci with a single sequence per species are likely to produce conflicting or even misleading results. To study these phenomena on a full phylogenomic scale, we use whole-genome sequence data from 200 individuals of four black-and-white flycatcher species with so far unresolved phylogenetic relationships to infer gene tree topologies and visualize genome-wide patterns of gene tree incongruence. Using phylogenetic analysis in nonoverlapping 10-kb windows, we show that gene tree topologies are extremely diverse and change on a very small physical scale. Moreover, we find strong evidence for gene flow among flycatcher species, with distinct patterns of reduced introgression on the Z chromosome. To resolve species relationships on the background of widespread gene tree incongruence, we used four complementary coalescent-based methods for species tree reconstruction, including complex modeling approaches that incorporate post-divergence gene flow among species. This allowed us to infer the most likely species tree with high confidence. Based on this finding, we show that regions of reduced effective population size, which have been suggested as particularly useful for species tree inference, can produce positively misleading species tree topologies. Our findings disclose the pitfalls of using loci potentially under selection as phylogenetic markers and highlight the potential of modeling approaches to disentangle species relationships in systems with large effective population sizes and post-divergence gene flow. PMID:26187295

A convenient and accurate wide-range parameter relationship between Buckingham and Morse potential energy functions

NASA Astrophysics Data System (ADS)

Lim, Teik-Cheng; Dawson, James Alexander

2018-05-01

This study explores the close-range, short-range and long-range relationships between the parameters of the Morse and Buckingham potential energy functions. The results show that the close-range and short-range relationships are valid for bond compression and for very small changes in bond length, respectively, while the long-range relationship is valid for bond stretching. A wide-range relationship is proposed to combine the comparative advantages of the close-range, short-range and long-range parameter relationships. The wide-range relationship is useful for replacing the close-range, short-range and long-range parameter relationships, thereby preventing the undesired effects of potential energy jumps resulting from functional switching between the close-range, short-range and long-range interaction energies.

Spherical Harmonic Inductive Detection Coils and their use In Dynamic Pre-emphasis for Magnetic Resonance Imaging

NASA Astrophysics Data System (ADS)

Edler, Karl T.

The issue of eddy currents induced by the rapid switching of magnetic field gradients is a long-standing problem in magnetic resonance imaging. A new method for dealing with this problem is presented whereby spatial harmonic components of the magnetic field are continuously sensed, through their temporal rates of change, and corrected. In this way, the effects of the eddy currents on multiple spatial harmonic components of the magnetic field can be detected and corrections applied during the rise time of the gradients. Sensing the temporal changes in each spatial harmonic is made possible with specially designed detection coils. However to make the design of these coils possible, general relationships between the spatial harmonics of the field, scalar potential, and vector potential are found within the quasi-static approximation. These relationships allow the vector potential to be found from the field -- an inverse curl operation -- and may be of use beyond the specific problem of detection coil design. Using the detection coils as sensors, methods are developed for designing a negative feedback system to control the eddy current effects and optimizing that system with respect to image noise and distortion. The design methods are successfully tested in a series of proof-of-principle experiments which lead to a discussion of how to incorporate similar designs into an operational MRI. Keywords: magnetic resonance imaging, eddy currents, dynamic shimming, negative feedback, quasi-static fields, vector potential, inverse curl

Investigation of Episodic Flow from Unsaturated Porous Media into a Macropore

DOE Office of Scientific and Technical Information (OSTI.GOV)

R. K. Podgorney; J. P. Fairley

Th e recent literature contains numerous observations of episodic or intermittent fl ow in unsaturated flow systems under both constant fl ux and ponded boundary conditions. Flow systems composed of a heterogeneous porous media, as well as discrete fracture networks, have been cited as examples of systems that can exhibit episodic fl ow. Episodic outfl ow events are significant because relatively large volumes of water can move rapidly through an unsaturated system, carrying water and contaminants to depth greatly ahead of a wetting front predicted by a one-dimensional, gravity-driven diff usive infiltration model. In this study, we model the behaviormore » of water flow through a sand column underlain by an impermeable-walled macropore. Relative permeability and capillary pressure relationships were developed that capture the complex interrelationships between the macropore and the overlying porous media that control fl ow out of the system. The potential for episodic flow is assessed and compared to results of conventional modeling approaches and experimental data from the literature. Model results using coupled matrix–macropore relative permeability and capillary pressure relationships capture the behavior observed in laboratory experiments remarkably well, while simulations using conventional relative permeability and capillary pressure functions fail to capture some of the observed fl ow dynamics. Capturing the rapid downward movement of water suggests that the matrix-macropore capillary pressure and relative permeability functions developed have the potential to improve descriptions of fl ow and transport processes in heterogeneous, variably saturated media.« less

Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids.

PubMed

Appiah-Kusi, E; Leyden, E; Parmar, S; Mondelli, V; McGuire, P; Bhattacharyya, S

2016-01-01

The aim of this article is to summarize current evidence regarding alterations in the neuroendocrine stress response system and endocannabinoid system and their relationship in psychotic disorders such as schizophrenia. Exposure to stress is linked to the development of a number of psychiatric disorders including psychosis. However, the precise role of stress in the development of psychosis and the possible mechanisms that might underlie this are not well understood. Recently the cannabinoid hypothesis of schizophrenia has emerged as a potential line of enquiry. Endocannabinoid levels are increased in patients with psychosis compared with healthy volunteers; furthermore, they increase in response to stress, which suggests another potential mechanism for how stress might be a causal factor in the development of psychosis. However, research regarding the links between stress and the endocannabinoid system is in its infancy. Evidence summarized here points to an alteration in the baseline tone and reactivity of the hypothalamic-pituitary-adrenal (HPA) axis as well as in various components of the endocannabinoid system in patients with psychosis. Moreover, the precise nature of the inter-relationship between these two systems is unclear in man, especially their biological relevance in the context of psychosis. Future studies need to simultaneously investigate HPA axis and endocannabinoid alterations both at baseline and following experimental perturbation in healthy individuals and those with psychosis to understand how they interact with each other in health and disease and obtain mechanistic insight as to their relevance to the pathophysiology of schizophrenia.

Stem Migration and Fretting Corrosion of the Antirotation Pin in the K2/Apex Hip System.

PubMed

Kent, Michael; Edmondson, Mark; Ebert, Jay; Nivbrant, Nils; Kop, Alan; Wood, David; De Steiger, Richard

2016-03-01

Many exchangeable neck hip systems have been withdrawn because of fretting corrosion at the neck/stem coupling. Our prospective randomized study evaluating stem stability (Roentgen stereophotogrammetric analysis, dual-energy x-ray absorptiometry) and clinical outcomes between the K2/Apex hip systems was ceased early because of a withdrawal of the stems which had an unfavorably high early revision rate reported in the Australian Orthopaedic Association National Joint Registry (9.3% at 3 years). At 2 years, there are no clinical differences between the stems. Roentgen stereophotogrammetric analysis has identified a high proportion of potentially concerning subsidence and retroversion in both groups, more marked in the K2 stem, although mostly in asymptomatic patients. Dual-energy x-ray absorptiometry has shown similar bone density around the stems. Retrieval analysis of 3 study patients showed fretting corrosion of the antirotation pin and aseptic lymphocyte-dominated vasculitis-associated lesion, with no relationship to bearing type or size. Analysis of 7 further nonstudy K2/Apex stems confirmed similar corrosion. This study shows potentially concerning subsidence of both stems and is the first to describe corrosion at the neck-stem interface and a relationship to metal-related pathology. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.

Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders

PubMed Central

Leopoldo, Marcello; Lacivita, Enza; Berardi, Francesco; Perrone, Roberto; Hedlund, Peter B.

2010-01-01

Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the central nervous system, serotonin (5-HT) has been shown to be involved in virtually all cognitive and behavioral human functions, and alterations in its neurochemistry have been implicated in the etiology of a plethora of neuropsychiatric disorders. The cloning of 5-HT receptor subtypes has been of importance in enabling them to be classified as specific protein molecules encoded by specific genes. The 5-HT7 receptor is the most recently classified member of the serotonin receptor family. Since its identification, it has been the subject of intense research efforts driven by its presence in functionally relevant regions of the brain. The availability of some selective antagonists and agonists, in combination with genetically modified mice lacking the 5-HT7 receptor, has allowed for a better understanding of the pathophysiological role of this receptor. This paper reviews data on localization and pharmacological properties of the 5-HT7 receptor, and summarizes the results of structure-activity relationship studies aimed at the discovery of selective 5-HT7 receptor ligands. Additionally, an overview of the potential therapeutic applications of 5-HT7 receptor agonists and antagonists in central nervous system disorders is presented. PMID:20923682

A Relationship Between the 2-body Energy of Kaxiras Pandey and Pearson Takai Halicioglu Tiller Potential Functions

NASA Astrophysics Data System (ADS)

Lim, Teik-Cheng

2004-01-01

A parametric relationship between the Pearson Takai Halicioglu Tiller (PTHT) and the Kaxiras Pandey (KP) empirical potential energy functions is developed for the case of 2-body interaction. The need for such relationship arises when preferred parametric data and adopted software correspond to different potential functions. The analytical relationship was obtained by equating the potential functions' derivatives at zeroth, first and second order with respect to the interatomic distance at the equilibrium bond length, followed by comparison of coefficients in the repulsive and attractive terms. Plots of non-dimensional 2-body energy versus the nondimensional interatomic distance verified the analytical relationships developed herein. The discrepancy revealed in theoretical plots suggests that the 2-body PTHT and KP potentials are more suitable for curve-fitting "softer" and "harder" bonds respectively.

Public-private partnerships in practice: collaborating to improve health finance policy in Ghana and Kenya.

PubMed

Suchman, Lauren; Hart, Elizabeth; Montagu, Dominic

2018-06-13

Social health insurance (SHI), one mechanism for achieving universal health coverage, has become increasingly important in low- and middle-income countries (LMICs) as they work to achieve this goal. Although small private providers supply a significant proportion of healthcare in LMICs, integrating these providers into SHI systems is often challenging. Public-private partnerships in health are one way to address these challenges, but we know little about how these collaborations work, how effectively, and why. Drawing on semi-structured interviews conducted with National Health Insurance (NHI) officials in Kenya and Ghana, as well as with staff from several international NGOs (INGOs) representing social franchise networks that are partnering to increase private provider accreditation into the NHIs, this article examines one example of public-private collaboration in practice. We found that interviewees initially had incomplete knowledge about the potential for cross-sector synergy, but both sides were motivated to work together around shared goals and the potential for mutual benefit. The public-private relationship then evolved over time through regular face-to-face interactions, reciprocal feedback, and iterative workplan development. This process led to a collegial relationship that also has given small private providers more voice in the health system. In order to sustain this relationship, we recommend that both public and private sector representatives develop formalized protocols for working together, as well as less formal open channels for communication. Models for aggregating small private providers and delivering them to government programmes as a package have potential to facilitate public-private partnerships as well, but there is little evidence on how these models work in LMICs thus far.

Quantitative Relationships between Photosynthetic, Nitrogen Fixing, and Fermentative H2 Metabolism in a Photosynthetic Microbial Mat

NASA Technical Reports Server (NTRS)

Hoehler, Tori M.; Albert, Daniel B.; Bebout, Brad M.; Turk, Kendra A.; DesMarais, David J.

2004-01-01

The ultimate potential of any microbial ecosystem to contribute chemically to its environment - and therefore, to impact planetary biogeochemistry or to generate recognizable biosignatures - depends not only on the individual metabolic capabilities of constituent organisms, but also on how those capabilities are expressed through interactions with neighboring organisms. This is particularly important for microbial mats, which compress an extremely broad range of metabolic potential into a small and dynamic system. H2 participates in many of these metabolic processes, including the major elemental cycling processes of photosynthesis, nitrogen fixation, sulfate reduction, and fermentation, and may therefore serve as a mediator of microbial interactions within the mat system. Collectively, the requirements of energy, electron transfer, and biomass element stoichiometry suggest quantitative relationships among the major element cycling processes, as regards H2 metabolism We determined experimentally the major contributions to 32 cycling in hypersaline microbial mats from Baja California, Mexico, and compared them to predicted relationships. Fermentation under dark, anoxic conditions is quantitatively the most important mechanism of H2 production, consistent with expectations for non-heterocystous mats such as those under study. Up to 16% of reducing equivalents fixed by photosynthesis during the day may be released by this mechanism. The direct contribution of nitrogen fixation to H2 production is small in comparison, but this process may indirectly stimulate substantial H2 generation, by requiring higher rates of fermentation. Sulfate reduction, aerobic consumption, diffusive and ebulitive loss, and possibly H2-based photoreduction of CO2 serve as the principal H2 sinks. Collectively, these processes interact to create an orders-of-magnitude daily variation in H2 concentrations and fluxes, and thereby in the oxidation-reduction potential that is imposed on microbial processes occuring within the mat matrix.

A note on the electrochemical nature of the thermoelectric power

NASA Astrophysics Data System (ADS)

Apertet, Y.; Ouerdane, H.; Goupil, C.; Lecoeur, Ph.

2016-04-01

While thermoelectric transport theory is well established and widely applied, it is not always clear in the literature whether the Seebeck coefficient, which is a measure of the strength of the mutual interaction between electric charge transport and heat transport, is to be related to the gradient of the system's chemical potential or to the gradient of its electrochemical potential. The present article aims to clarify the thermodynamic definition of the thermoelectric coupling. First, we recall how the Seebeck coefficient is experimentally determined. We then turn to the analysis of the relationship between the thermoelectric power and the relevant potentials in the thermoelectric system: As the definitions of the chemical and electrochemical potentials are clarified, we show that, with a proper consideration of each potential, one may derive the Seebeck coefficient of a non-degenerate semiconductor without the need to introduce a contact potential as seen sometimes in the literature. Furthermore, we demonstrate that the phenomenological expression of the electrical current resulting from thermoelectric effects may be directly obtained from the drift-diffusion equation.

Concepts to Support HRP Integration Using Publications and Modeling

NASA Technical Reports Server (NTRS)

Mindock, J.; Lumpkins, S.; Shelhamer, M.

2014-01-01

Initial efforts are underway to enhance the Human Research Program (HRP)'s identification and support of potential cross-disciplinary scientific collaborations. To increase the emphasis on integration in HRP's science portfolio management, concepts are being explored through the development of a set of tools. These tools are intended to enable modeling, analysis, and visualization of the state of the human system in the spaceflight environment; HRP's current understanding of that state with an indication of uncertainties; and how that state changes due to HRP programmatic progress and design reference mission definitions. In this talk, we will discuss proof-of-concept work performed using a subset of publications captured in the HRP publications database. The publications were tagged in the database with words representing factors influencing health and performance in spaceflight, as well as with words representing the risks HRP research is reducing. Analysis was performed on the publication tag data to identify relationships between factors and between risks. Network representations were then created as one type of visualization of these relationships. This enables future analyses of the structure of the networks based on results from network theory. Such analyses can provide insights into HRP's current human system knowledge state as informed by the publication data. The network structure analyses can also elucidate potential improvements by identifying network connections to establish or strengthen for maximized information flow. The relationships identified in the publication data were subsequently used as inputs to a model captured in the Systems Modeling Language (SysML), which functions as a repository for relationship information to be gleaned from multiple sources. Example network visualization outputs from a simple SysML model were then also created to compare to the visualizations based on the publication data only. We will also discuss ideas for building upon this proof-of-concept work to further support an integrated approach to human spaceflight risk reduction.

Interoperability between loose-coupled distributed resources and application across autonomous systems

NASA Astrophysics Data System (ADS)

Arrott, M.; Orcutt, J.; Chave, A.

2005-12-01

The following is an example to illustrate the concept, possibilities and issues associated with the interoperability between loose-coupled distributed resources and application across autonomous systems. Take, for example, printing. If you are in your office (or home office) environment, it is likely that you select "Print" in your application, select a printer from the list of printers offered those "loaded" onto your computer, and your computer communicates directly with the selected printer to produce a paper copy of your document. If you are sitting in a coffee shop, however, selecting the same printer likely produces no immediate results. Imagine if, in contrast to the scenario just outlined, your selection of the "Print" command produced a list of printers available at nearby copy service shops (e.g., Ali's Copy & Print), public libraries and "friends you forgot you had." This list might include information regarding how far the printer is from your current location and how much you would be charged to print your document on it. Deciding that you'll gladly pay .30 cents to save a half mile walk, you select Ali's Copy & Print. Your system authorizes payment, Ali's Copy & Print authorizes service, and your document appears on Ali's printer, ready for pickup. This latter scenario requires the introduction of a layer of negotiation between producers and consumers of network services that is not available today. Rather than a resource consumer (your application) seeking to connect to a specific resource (your printer), a resource consumer presents a request for service which one or more producers offer to fill. The beginning and the end of the transaction remain unchanged: you select the print command and the system presents potential printers, and, eventually, your system presents a command to a printer: however, an intermediate negotiation takes place to determine the when, where who and how. The implication of this model is that, fundamentally, networks must shift from being collections of known resources to being confederated communities of potential resources. In other words, producers must be able to advertise their services, consumers must be able to present their needs, and the two must be able to reach an agreement on services rendered and payments received. Creating a confederated community of potential resources poses three basic technical challenges. First, collaborating parties in a service must be able to describe, identify and communicate themselves in manner that is mutually understandable. Second, parties must be able to establish trust that each are legitimate; potentially requiring mutually trusted third party verification. Third, parties must be able to govern negotiations and agreements in which they participate. This presentation addresses these three challenges in manner that provides a durable set of solutions, by investigate the following questions in the context of a loose-coupled distributed environment between autonomous systems: 1. Characterize the domain of the relationship between the resources offered by one autonomous system and the utilization of those resource by applications used in another autonomous system? 2. What models of interactions can be employed to support the domain of relationship? 3. What are the metrics for evaluating these relationships? 4. What changes the nature of the relationship between the resource and the application?

The role of organisational support in teleworker wellbeing: a socio-technical systems approach.

PubMed

Bentley, T A; Teo, S T T; McLeod, L; Tan, F; Bosua, R; Gloet, M

2016-01-01

The prevalence of telework and other forms of mobile working enabled by digital technology is increasing markedly. Following a socio-technical systems approach, this study aims to examine the role of organisational social support and specific support for teleworkers in influencing teleworker wellbeing, the mediating role of social isolation, potentially resulting from a person-environment mismatch in these relationships, and possible differences in these relationships between low-intensity and hybrid teleworkers. Teleworkers' (n = 804) perceptions of support and telework outcomes (psychological strain, job satisfaction, and social isolation) were collected using an on-line survey of teleworking employees distributed within 28 New Zealand organisations where knowledge work was undertaken. Organisational social support and teleworker support was associated with increased job satisfaction and reduced psychological strain. Social isolation mediated the relationship between organisational social support and the two outcome variables, and some differences were observed in the structural relationships for hybrid and low-intensity teleworker sub-samples. These findings suggest that providing the necessary organisational and teleworker support is important for enhancing the teleworker-environment fit and thereby ensuring desirable telework outcomes. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Estimating Surface NO2 and SO2 Mixing Ratios from Fast-Response Total Column Observations and Potential Application to Geostationary Missions

EPA Science Inventory

Total-column nitrogen dioxide (NO2) data collected by a ground-based sun-tracking spectrometer system 21 (Pandora) and an photolytic-converter-based in-situ instrument collocated at NASA’s Langley Research Center in 22 Hampton, Virginia were analyzed to study the relationship bet...

DOE Office of Scientific and Technical Information (OSTI.GOV)

CATO DM; DAHL MM; PHILO GL

This report documents the results of tests designed to characterize the relationship between temperature and the measured potential of electrodes installed on multi-probe corrosion monitoring systems in waste tanks. This report also documents the results of tests designed to demonstrate the impact of liquid in-leakage into electrode bodies as well as the contamination of primary reference electrodes by diffusion through the electrode tip.

Getting to Green: An Examination of the Relationship between Institutional Characteristics and Sustainability Achievement at Four-Year U.S. Based Colleges and Universities

ERIC Educational Resources Information Center

Miller, Justin

2014-01-01

This study presents an examination of how institutional characteristics might influence a four-year institution of higher education's achievement in sustainability, as measured by the Sustainability Tracking, Assessment, and Rating System (STARS). Specifically, it examined the potential role Carnegie classification, sector, location, number of…

An Unscented Kalman Filter Approach to the Estimation of Nonlinear Dynamical Systems Models

ERIC Educational Resources Information Center

Chow, Sy-Miin; Ferrer, Emilio; Nesselroade, John R.

2007-01-01

In the past several decades, methodologies used to estimate nonlinear relationships among latent variables have been developed almost exclusively to fit cross-sectional models. We present a relatively new estimation approach, the unscented Kalman filter (UKF), and illustrate its potential as a tool for fitting nonlinear dynamic models in two ways:…

Organ Preference of Cancer Metastasis and Metastasis-Related Cell Adhesion Molecules Including Carbohydrates.

PubMed

Kawaguchi, Takanori

2016-01-01

This review starts on one of our special interests, the organ preference of metastasis. We examined data on 1,117 autopsy cases and found that the organ distribution of metastasis of cancers of the lung, pancreas, stomach, colon, rectum, uterine cervix, liver, bile duct, and esophagus involved the lung, liver, adrenal gland, bone/bone marrow, lymph node, and pleura/peritoneum. Cancers of the kidney, thyroid, ovary, choriocarcinoma, and breast, however, manifested different metastatic patterns. The distribution of leukemia and lymphoma metastases was quite different from that of epithelial cancers. On the basis of experimental studies, we believe that the anatomical-mechanical hypothesis should be replaced by the microinjury hypothesis, which suggests that tissue microinjury induced by temporal tumor cell embolization is crucial for successful metastasis. This hypothesis may actually reflect the so-called inflammatory oncotaxis concept. To clarify the mechanisms underlying metastasis, we developed an experimental model system of a rat hepatoma AH7974 that embraced substrate adhesiveness. This model did not prove a relationship between substrate-adhesion potential and metastatic lung-colonizing potential of tumor cells, but metastatic potential was correlated with the expression of the laminin carbohydrate that was recognized by Griffonia (Bandeiraea) simplicifolia isolectin G4. Therefore, we investigated the relationship between carbohydrate expression profiles and metastasis and prognosis. We indeed found an intimate relationship between the carbohydrate expression of cancer cells and the progression of malignant tumors, organ preference of metastasis, metastatic potential of tumor cells, and prognosis of patients.

Three critical questions for future research on lesbian relationships.

PubMed

Diamond, Lisa M

2017-01-02

In this article I discuss three questions that should be priorities for future research on lesbian love and relationships. The first question concerns the very definition of "lesbian relationship," given how many women may be engaged in same-sex relationships without identifying as lesbian. The second question concerns the potential influence of childhood neglect and abuse on adult women's same-sex relationships, a topic that has important implications for both psychological well-being and relationship functioning. The third question concerns the potential downsides of legal marriage for women's same-sex relationships, a topic that is particularly important in light of the newfound legal recognition of same-sex marriage in all 50 states. Although there are many understudied questions in the domain of women's same-sex relationships, research on these three questions has particularly strong potential to advance our understanding of lesbian love and relationships in important ways.

Constructiveness and destructiveness of temperature in asymmetric quantum pseudo dot qubit system

NASA Astrophysics Data System (ADS)

Chen, Ying-Jie; Song, Hai-Tao; Xiao, Jing-Lin

2018-06-01

By using the variational method of the Pekar type, we theoretically study the temperature effects on the asymmetric quantum pseudo dot qubit with a pseudoharmonic potential under an electromagnetic field. The numerical results are analyzed and discussed in detail and show that the relationships of the ground and first excited state energies, the electron oscillation period and the electron probability density in the superposition state of the ground state and the first-excited state with the temperature, the chemical potential, the pseudoharmonic potential, the electric field strength, the cyclotron frequency, the electron phonon coupling constant, the transverse and longitudinal effective confinement length, respectively.

Construction of the landscape for multi-stable systems: Potential landscape, quasi-potential, A-type integral and beyond

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Peijie, E-mail: cliffzhou@pku.edu.cn; Li, Tiejun, E-mail: tieli@pku.edu.cn

Motivated by the famous Waddington’s epigenetic landscape metaphor in developmental biology, biophysicists and applied mathematicians made different proposals to construct the landscape for multi-stable complex systems. We aim to summarize and elucidate the relationships among these theories from a mathematical point of view. We systematically investigate and compare three different but closely related realizations in the recent literature: the Wang’s potential landscape theory from steady state distribution of stochastic differential equations (SDEs), the Freidlin-Wentzell quasi-potential from the large deviation theory, and the construction through SDE decomposition and A-type integral. We revisit that the quasi-potential is the zero noise limit ofmore » the potential landscape, and the potential function in the third proposal coincides with the quasi-potential. We compare the difference between local and global quasi-potential through the viewpoint of exchange of limit order for time and noise amplitude. We argue that local quasi-potentials are responsible for getting transition rates between neighboring stable states, while the global quasi-potential mainly characterizes the residence time of the states as the system reaches stationarity. The difference between these two is prominent when the transitivity property is broken. The most probable transition path by minimizing the Onsager-Machlup or Freidlin-Wentzell action functional is also discussed. As a consequence of the established connections among different proposals, we arrive at the novel result which guarantees the existence of SDE decomposition while denies its uniqueness in general cases. It is, therefore, clarified that the A-type integral is more appropriate to be applied to the decomposed SDEs rather than its primitive form as believed by previous researchers. Our results contribute to a deeper understanding of landscape theories for biological systems.« less

Construction of the landscape for multi-stable systems: Potential landscape, quasi-potential, A-type integral and beyond

NASA Astrophysics Data System (ADS)

Zhou, Peijie; Li, Tiejun

2016-03-01

Motivated by the famous Waddington's epigenetic landscape metaphor in developmental biology, biophysicists and applied mathematicians made different proposals to construct the landscape for multi-stable complex systems. We aim to summarize and elucidate the relationships among these theories from a mathematical point of view. We systematically investigate and compare three different but closely related realizations in the recent literature: the Wang's potential landscape theory from steady state distribution of stochastic differential equations (SDEs), the Freidlin-Wentzell quasi-potential from the large deviation theory, and the construction through SDE decomposition and A-type integral. We revisit that the quasi-potential is the zero noise limit of the potential landscape, and the potential function in the third proposal coincides with the quasi-potential. We compare the difference between local and global quasi-potential through the viewpoint of exchange of limit order for time and noise amplitude. We argue that local quasi-potentials are responsible for getting transition rates between neighboring stable states, while the global quasi-potential mainly characterizes the residence time of the states as the system reaches stationarity. The difference between these two is prominent when the transitivity property is broken. The most probable transition path by minimizing the Onsager-Machlup or Freidlin-Wentzell action functional is also discussed. As a consequence of the established connections among different proposals, we arrive at the novel result which guarantees the existence of SDE decomposition while denies its uniqueness in general cases. It is, therefore, clarified that the A-type integral is more appropriate to be applied to the decomposed SDEs rather than its primitive form as believed by previous researchers. Our results contribute to a deeper understanding of landscape theories for biological systems.

Carnivore stable carbon isotope niches reflect predator-prey size relationships in African savannas.

PubMed

Codron, Jacqueline; Avenant, Nico L; Wigley-Coetsee, Corli; Codron, Daryl

2018-03-01

Predator-prey size relationships are among the most important patterns underlying the structure and function of ecological communities. Indeed, these relationships have already been shown to be important for understanding patterns of macroevolution and differential extinction in the terrestrial vertebrate fossil record. Stable isotope analysis (SIA) is a powerful remote approach to examining animal diets and paleodiets. The approach is based on the principle that isotope compositions of consumer tissues reflect those of their prey. In systems where resource isotope compositions are distributed along a body size gradient, SIA could be used to reconstruct predator-prey size relationships. We analyzed stable carbon isotope distributions amongst mammalian herbivores in extant and Plio-Pleistocene African savanna assemblages, and show that the range of δ 13 C values among mammalian prey species (herbivores and rodents) increases with body mass (BM), because C 4 plant feeding (essentially grazing) is more common among larger taxa. Consequently, δ 13 C values of mammalian carnivores in these systems are related to species' BM, reflecting a higher average C 4 prey component in the diets of larger-bodied carnivores. This pattern likely emerges because only the largest carnivores in these systems have regular access to the C 4 prey base, whereas smaller carnivores do not. The δ 13 C-BM relationship observed in mammalian carnivores is a potentially powerful approach for reconstructing and parameterizing predator-prey size relationships in contemporary and fossil savanna assemblages, and for interpreting how various behavioral, ecological and environmental factors influence prey size selection. © 2017 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.

Using Empirical Data to Estimate Potential Functions in Commodity Markets: Some Initial Results

NASA Astrophysics Data System (ADS)

Shen, C.; Haven, E.

2017-12-01

This paper focuses on estimating real and quantum potentials from financial commodities. The log returns of six common commodities are considered. We find that some phenomena, such as the vertical potential walls and the time scale issue of the variation on returns, also exists in commodity markets. By comparing the quantum and classical potentials, we attempt to demonstrate that the information within these two types of potentials is different. We believe this empirical result is consistent with the theoretical assumption that quantum potentials (when embedded into social science contexts) may contain some social cognitive or market psychological information, while classical potentials mainly reflect `hard' market conditions. We also compare the two potential forces and explore their relationship by simply estimating the Pearson correlation between them. The Medium or weak interaction effect may indicate that the cognitive system among traders may be affected by those `hard' market conditions.

Telepsychotherapy and the Therapeutic Relationship: Principles, Advantages, and Case Examples.

PubMed

Kocsis, Barbara J; Yellowlees, Peter

2018-05-01

As the use of technology continues to expand within our mental healthcare system, there has been an increasing interest in conducting psychotherapy online using videoconferencing. Literature pertaining to telepsychotherapy has explored possible drawbacks of this modality on the therapeutic relationship, although several studies have shown that the efficacy of online psychotherapy is equivalent to in-person approaches. Little is written about the potential advantages to the psychotherapeutic relationship when psychotherapy is carried out over videoconferencing. The available literature was reviewed, as were the general principles of telepsychotherapy and the therapeutic relationship, followed by a more in-depth consideration of patient populations for whom telepsychotherapy may offer distinct advantages. The current literature, as well as our own clinical experience, suggests that telepsychotherapy may be effective for a broad range of patients, and it may offer distinct advantages in the building of a trusting psychotherapeutic relationship. Telepsychotherapy offers a novel way to reach and form strong psychotherapeutic relationships with many different types of patients, and it may foster therapeutic intimacy in ways that in-person psychotherapy cannot. More research is needed to further explore this unique modality.

Relational and systems methodologies for analysing parent-child relationships: an exploration of conflict, support and independence in adolescence and post-adolescence.

PubMed

Honess, T M; Lintern, F

1990-12-01

Research procedures which constitute a significant reorientation towards relational rather than individually focused methods are critically reviewed. A novel 'paired interview' strategy, consistent with this relational paradigm, is employed in two research studies. The first study involves the analysis of 18 mother-adolescent son/daughter relationships at the time when the young people had just left school at the age of 16. A relationship typology was developed for these 18 pairs and it is demonstrated that the themes of conflict, independence and interdependence can be operationalized using this procedure. The second study involves the analysis of 25 mother and post-adolescent daughter relationships to test the proposition that such relationships are inherently conflicted. Taken together, the two studies demonstrate that mothers and daughters are not chronically conflicted in their relationships. Nevertheless, the potential for conflict may be a significant element in accounting for girls' adolescent development. However, on entering early adulthood, the young women typically reach a state of 'interdependence' with their mothers.

Infusing Technology into Customer Relationships: Balancing High-Tech and High-Touch

NASA Astrophysics Data System (ADS)

Salomann, Harald; Kolbe, Lutz; Brenner, Walter

In today's business environment, self-service is becoming increasingly important. In order to promote their self-service activities, banks have created online-only products and airlines offer exclusive discounts for passengers booking online. Self-service technologies' practical applications demonstrate this approach's potential. For example, Amtrak introduced an IVR (Interactive Voice Response) system, allowing cost savings of 13m; likewise Royal Mail installed an IVR system leading to a reduction of its customer service costs by 25% (Economist 2004).

[Redox-potential of blood and consistence of energoproviding defence system in cytomegalovirus infection in pregnancy].

PubMed

Dzhikiia, I V; Rizhvadze, M A; Dzhangidze, M A

2006-05-01

We have studied the relationship between the hypoxic change and mitochondrial redox-potential disturbances in the mechanism of pheto-placental insufficiency in pregnancy with cytomegalovirus infection (CMV), detected by the positive anti-CMV-IgG titer and more then 4-fold increase of low avid anti-CMV-IgG. It was shown, that chronic CMV infection induces production of active forms of oxygen, peroxidation of structures and concurrently damage of mitochondria with essential decrease of ATP level. Results of the study have shown the important diagnostic value of estimation of hypoxic-oxidative damage induced by CMV infection. The results also revealed important relationships between the activity of the CMV infection and intensity of mitochondrial damage. On the basis of our investigations we suggest the additional diagnostic test (the determination of citozol NADH dependent isocitratdehydrogenaze activity) to evaluate the depth of CMV induced metabolic disturbances.

Feasibility and Utility of Lexical Analysis for Occupational Health Text.

PubMed

Harber, Philip; Leroy, Gondy

2017-06-01

Assess feasibility and potential utility of natural language processing (NLP) for storing and analyzing occupational health data. Basic NLP lexical analysis methods were applied to 89,000 Mine Safety and Health Administration (MSHA) free text records. Steps included tokenization, term and co-occurrence counts, term annotation, and identifying exposure-health effect relationships. Presence of terms in the Unified Medical Language System (UMLS) was assessed. The methods efficiently demonstrated common exposures, health effects, and exposure-injury relationships. Many workplace terms are not present in UMLS or map inaccurately. Use of free text rather than narrowly defined numerically coded fields is feasible, flexible, and efficient. It has potential to encourage workers and clinicians to provide more data and to support automated knowledge creation. The lexical method used is easily generalizable to other areas. The UMLS vocabularies should be enhanced to be relevant to occupational health.

Cavitation damage prediction for spallation target vessels by assessment of acoustic vibration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Futakawa, Masatoshi; Kogawa, Hiroyuki; Hasegawa, Shoichi

2008-01-01

Liquid-mercury target systems for MW-class spallation neutron sources are being developed around the world. Proton beams are used to induce the spallation reaction. At the moment the proton beam hits the target, pressure waves are generated in the mercury because of the abrupt heat deposition. The pressure waves interact with the target vessel leading to negative pressure that may cause cavitation along the vessel wall. In order to estimate the cavitation erosion, i.e. the pitting damage formed by the collapse of cavitation bubbles, off-beam tests were performed by using an electric magnetic impact testing machine (MIMTM), which can impose equivalentmore » pressure pulses in mercury. The damage potential was defined based on the relationship between the pitting damage and the time-integrated acoustic vibration induced by impact due to the bubble collapses. Additionally, the damage potential was measured in on-beam tests carried out by using the proton beam at WNR (Weapons Neutron Research) facility in Los Alamos Neutron Science Center (LANSCE). In this paper, the concept of the damage potential, the relationship between the pitting damage formation and the damage potential both in off-beam and on-beam tests is shown.« less

Therapeutic potential of cannabinoids in schizophrenia.

PubMed

Kucerova, Jana; Tabiova, Katarina; Drago, Filippo; Micale, Vincenzo

2014-04-01

Increasing evidence suggests a close relationship between the endocannabinoid system and schizophrenia. The endocannabinoid system comprises of two G protein-coupled receptors (the cannabinoid receptors 1 and 2 [CB1 and CB2] for marijuana's psychoactive principle Δ(9)-tetrahydrocannabinol), their endogenous small lipid ligands (namely anandamide [AEA] and 2-arachidonoylglycerol [2-AG], also known as endocannabinoids), and proteins for endocannabinoid biosynthesis and degradation. It has been suggested to be a pro-homeostatic and pleiotropic signalling system activated in a time- and tissue-specific manner during pathophysiological conditions. In the brain, activation of this system impacts the release of numerous neurotransmitters in various systems and cytokines from glial cells. Hence, the endocannabinoid system is strongly involved in neuropsychiatric disorders, such as schizophrenia. Therefore, adolescence use of Cannabis may alter the endocannabinoid signalling and pose a potential environmental risk to develop psychosis. Consistently, preclinical and clinical studies have found a dysregulation in the endocannabinoid system such as changed expression of CB1 and CB2 receptors or altered levels of AEA and 2-AG . Thus, due to the partial efficacy of actual antipsychotics, compounds which modulate this system may provide a novel therapeutic target for the treatment of schizophrenia. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of schizophrenic symptomatology. Furthermore, this review will be highlighting the therapeutic potential of cannabinoid-related compounds and presenting some promising patents targeting potential treatment options for schizophrenia.

On modeling complex interplay in small-scale self-organized socio-hydrological systems

NASA Astrophysics Data System (ADS)

Muneepeerakul, Rachata

2017-04-01

Successful and sustainable socio-hydrological systems, as in any coupled natural human-systems, require effective governance, which depends on the existence of proper infrastructure (both hard and soft). Recent work has addressed systems in which resource users and the organization responsible for maintaining the infrastructure are separate entities. However, many socio-hydrological systems, especially in developing countries, are small and without such formal division of labor; rather, such division of labor typically arises from self-organization within the population. In this work, we modify and mathematically operationalize a conceptual framework by developing a system of differential equations that capture the strategic behavior within such a self-organized population, its interplay with infrastructure characteristics and hydrological dynamics, and feedbacks between these elements. The model yields a number of insightful conditions related to long-term sustainability and collapse of the socio-hydrological system in the form of relationships between biophysical and social factors. These relationships encapsulate nonlinear interactions of these factors. The modeling framework is grounded in a solid conceptual foundation upon which additional modifications and realism can be built for potential reconciliation between socio-hydrology with other related fields and further applications.

Resting blood pressure differentially predicts time course in a tonic pain experiment.

PubMed

Horing, Bjoern; McCubbin, James A; Moore, Dewayne; Muth, Eric R

2016-10-01

Resting blood pressure (BP) shows a negative relationship with pain sensitivity (BP-related hypoalgesia). In chronic pain conditions, this relationship is inverted. The precise mechanisms responsible for the inversion are unknown. Using a tonic pain protocol, we report findings closely resembling this inversion in healthy participants. Resting BP and state measures of anxiety and mood were assessed from 33 participants (21 female). Participants then immersed their dominant hand in painfully hot water (47 °C) for five trials of 1-min duration, with 30-s intertrial intervals. Throughout the trials, participants continually registered their pain. After a 35-min intermission, the trial sequence was repeated. A disassociation of the negative relationship of resting systolic BP (as per Trial 1) was found using hierarchical linear modeling (p < .001, R(2)  = .07). The disassociation unfolds over each consecutive trial, with an increasingly positive relationship. In Sequence 2, the initially negative relationship is almost completely absent. Furthermore, the association of BP and pain was found to be moderated by anxiety, such that only persons with low anxiety exhibited BP hypoalgesia. Our findings expand the existing literature by incorporating anxiety as a moderator of BP hypoalgesia. Furthermore, the protocol emulates the changing relationship between BP and pain observed in chronic pain patients. The protocol has potential as a model for chronic pain; however, future research should determine if similar physiological systems are involved. The finding holds potential diagnostic or prognostic relevance for certain clinical pain conditions, especially those involving dysfunction of the descending modulation of pain. © 2016 Society for Psychophysiological Research.

Thermostatistical description of gas mixtures from space partitions

NASA Astrophysics Data System (ADS)

Rohrmann, R. D.; Zorec, J.

2006-10-01

The new mathematical framework based on the free energy of pure classical fluids presented by Rohrmann [Physica A 347, 221 (2005)] is extended to multicomponent systems to determine thermodynamic and structural properties of chemically complex fluids. Presently, the theory focuses on D -dimensional mixtures in the low-density limit (packing factor η<0.01 ). The formalism combines the free-energy minimization technique with space partitions that assign an available volume v to each particle. v is related to the closeness of the nearest neighbor and provides a useful tool to evaluate the perturbations experimented by particles in a fluid. The theory shows a close relationship between statistical geometry and statistical mechanics. New, unconventional thermodynamic variables and mathematical identities are derived as a result of the space division. Thermodynamic potentials μil , conjugate variable of the populations Nil of particles class i with the nearest neighbors of class l are defined and their relationships with the usual chemical potentials μi are established. Systems of hard spheres are treated as illustrative examples and their thermodynamics functions are derived analytically. The low-density expressions obtained agree nicely with those of scaled-particle theory and Percus-Yevick approximation. Several pair distribution functions are introduced and evaluated. Analytical expressions are also presented for hard spheres with attractive forces due to Kac-tails and square-well potentials. Finally, we derive general chemical equilibrium conditions.

Dynamic Systems Analysis for Turbine Based Aero Propulsion Systems

NASA Technical Reports Server (NTRS)

Csank, Jeffrey T.

2016-01-01

The aircraft engine design process seeks to optimize the overall system-level performance, weight, and cost for a given concept. Steady-state simulations and data are used to identify trade-offs that should be balanced to optimize the system in a process known as systems analysis. These systems analysis simulations and data may not adequately capture the true performance trade-offs that exist during transient operation. Dynamic systems analysis provides the capability for assessing the dynamic tradeoffs at an earlier stage of the engine design process. The dynamic systems analysis concept, developed tools, and potential benefit are presented in this paper. To provide this capability, the Tool for Turbine Engine Closed-loop Transient Analysis (TTECTrA) was developed to provide the user with an estimate of the closed-loop performance (response time) and operability (high pressure compressor surge margin) for a given engine design and set of control design requirements. TTECTrA along with engine deterioration information, can be used to develop a more generic relationship between performance and operability that can impact the engine design constraints and potentially lead to a more efficient engine.

Examining Autism Spectrum Disorders by Biomarkers: Example From the Oxytocin and Serotonin Systems

PubMed Central

Hammock, Elizabeth; Veenstra-VanderWeele, Jeremy; Yan, Zhongyu; Kerr, Travis M.; Morris, Marianna; Anderson, George; Carter, C. Sue; Cook, Edwin H.; Jacob, Suma

2013-01-01

Objective Autism Spectrum Disorder (ASD) is a heritable but highly heterogeneous neuropsychiatric syndrome, which poses challenges for research relying solely on behavioral symptoms or diagnosis. Examining biomarkers may give us ways to identify individuals who demonstrate specific developmental trajectories and etiological factors related to ASD. Plasma oxytocin (OT) and whole blood serotonin (5-HT) levels are consistently altered in some individuals with ASD. Reciprocal relationships have been described between brain oxytocin and serotonin systems during development. We therefore investigated the relationship between these peripheral biomarkers as well as their relationships with age. Method In our first study, we analyzed correlations between these two biomarkers in 31 children and adolescents who were diagnosed with autism and were not on medications. In our second study, we explored whether whole blood 5-HT levels are altered in mice lacking the oxytocin receptor gene, Oxtr. Results In humans, OT and 5-HT were negatively correlated with each other (p<0.05) and this relationship was most prominent in children under 11 years old. Paralleling human findings, mice lacking Oxtr showed increased whole blood 5-HT levels (p=0.05), with this effect driven exclusively by mice younger than 4 months of age (p< 0.01). Conclusions Identifying relationships between identified ASD biomarkers may be a useful approach to connect otherwise disparate findings that span multiple systems in this heterogeneous disorder. Using neurochemical biomarkers to do parallel studies in animal and human populations within a developmental context is a plausible approach to probe the root causes of ASD and identify potential interventions. PMID:22721594

Predicting catastrophes of non-autonomous networks with visibility graphs and horizontal visibility

NASA Astrophysics Data System (ADS)

Zhang, Haicheng; Xu, Daolin; Wu, Yousheng

2018-05-01

Prediction of potential catastrophes in engineering systems is a challenging problem. We first attempt to construct a complex network to predict catastrophes of a multi-modular floating system in advance of their occurrences. Response time series of the system can be mapped into an virtual network by using visibility graph or horizontal visibility algorithm. The topology characteristics of the networks can be used to forecast catastrophes of the system. Numerical results show that there is an obvious corresponding relationship between the variation of topology characteristics and the onset of catastrophes. A Catastrophe Index (CI) is proposed as a numerical indicator to measure a qualitative change from a stable state to a catastrophic state. The two approaches, the visibility graph and horizontal visibility algorithms, are compared by using the index in the reliability analysis with different data lengths and sampling frequencies. The technique of virtual network method is potentially extendable to catastrophe predictions of other engineering systems.

Potential effects of alterations to the hydrologic system on the distribution of salinity in the Biscayne aquifer in Broward County, Florida

USGS Publications Warehouse

Hughes, Joseph D.; Sifuentes, Dorothy F.; White, Jeremy T.

2016-03-15

Model accuracy and use are limited by uncertainty in the physical properties and boundary conditions of the system, uncertainty in historical and future conditions, and generalizations made in the mathematical relationships used to describe the physical processes of groundwater flow and transport. Because of these limitations, model results should be considered in relative rather than absolute terms. Nonetheless, model results do provide useful information on the relative scale of response of the system to changes in pumping distribution, sea-level rise, and mitigation activities.

Integrating Speech and Iconic Gestures in a Stroop-Like Task: Evidence for Automatic Processing

ERIC Educational Resources Information Center

Kelly, Spencer D.; Creigh, Peter; Bartolotti, James

2010-01-01

Previous research has demonstrated a link between language and action in the brain. The present study investigates the strength of this neural relationship by focusing on a potential interface between the two systems: cospeech iconic gesture. Participants performed a Stroop-like task in which they watched videos of a man and a woman speaking and…

Vermont's Act 60: Comprehensive School Finance Reform--Effects in the First Year of Full Implementation.

ERIC Educational Resources Information Center

Mathis, William J.; Fleming, Brenda L.

Vermont's Act 60 received national attention not only because of the controversy surrounding the sharing pool (or recapture provision) but also because of its "potential for being the most equitable system in the country." For fiscal years 1998 to 2001, tax rates have become more equitable, and a direct relationship has appeared between…

Roads in landscape modeling: a case study of a road data layer and use in the interior northwest landscape analysis system.

Treesearch

Marti Aitken; Jane L. Hayes

2006-01-01

Roads are important ecological features of forest landscapes, but their cause-and effect relationships with other ecosystem components are only recently becoming included in integrated landscape analyses. Simulation models can help us to understand how forested landscapes respond over time to disturbance and socioeconomic factors, and potentially to address the...

Relationships among climate, forests, and insects in North America: Examples of the importance of long-term and broad-scale perspectives

Treesearch

Talbot Trotter

2013-01-01

Forest structure is strongly influenced by disturbance, agents of which can include fire, weather, mammals, annelids, fungi, insects, and increasingly with the advent of the Anthropocene, climate. Currently, climate change represents one of the broadest threats to natural systems, including forests, with the potential to directly alter forest structure and function...

The Interdependence of Adult Relationship Quality and Parenting Behaviours among African American and European Couples in Rural, Low-Income Communities

ERIC Educational Resources Information Center

Zvara, Bharathi J.; Mills-Koonce, W. Roger; Heilbron, Nicole; Clincy, Amanda; Cox, Martha J.

2015-01-01

The present study extends the spillover and crossover hypotheses to more carefully model the potential interdependence between parent-parent interaction quality and parent-child interaction quality in family systems. Using propensity score matching, the present study attempted to isolate family processes that are unique across African American and…

Slow-cycle effects of foliar herbivory alter the nitrogen acquisition and population size of Collembola

Treesearch

Mark A. Bradford; Tara Gancos; Christopher J. Frost

2008-01-01

In terrestrial systems there is a close relationship between litter quality and the activity and abundance of decomposers. Therefore, the potential exists for aboveground, herbivore-induced changes in foliar chemistry to affect soil decomposer fauna. These herbivore-induced changes in chemistry may persist across growing seasons. While the impacts of such slow-cycle...

Fault Tree Analysis: An Operations Research Tool for Identifying and Reducing Undesired Events in Training.

ERIC Educational Resources Information Center

Barker, Bruce O.; Petersen, Paul D.

This paper explores the fault-tree analysis approach to isolating failure modes within a system. Fault tree investigates potentially undesirable events and then looks for failures in sequence that would lead to their occurring. Relationships among these events are symbolized by AND or OR logic gates, AND used when single events must coexist to…

Relationships among Factors in New Officer Effectiveness Report System. Final Report for Period 15 December 1975-30 April 1978.

ERIC Educational Resources Information Center

Bottenberg, Robert A.

To investigate operating characteristics of performance factors and the evaluation of potential ratings for new officers, an analysis of controlled effectiveness for 9,230 lieutenant colonels was performed. The study was done to determine whether performance factor variance was so restricted that the performance factors would not provide useful…

Project Final Report: Linking Plant Stress, Biogenic SOA, and CCN Production - A New Feedback in the Climate System?

DOE Office of Scientific and Technical Information (OSTI.GOV)

VanReken, Timothy; Balasingam, Muhunthan

2017-05-01

This project worked toward understanding the role of variable biogenic emissions in the formation of secondary organic aerosol (SOA), and in turn the potential for this aerosol to affect cloud droplet formation. It was premised on the idea that a changing climate could impose biogenic and abiogenic stresses on plants that would affect the emissions of volatile organic compounds (VOCs). The transformation of these VOCs to SOA and cloud condensation nuclei (CCN) implied the possibility of a feedback mechanism within the biosphere/atmosphere/climate system. The project’s activities centered on laboratory experiments to study the effects of stresses on plants and plant-derivedmore » material under controlled conditions, observing both the VOC emissions and the aerosol that formed from the oxidation of those VOCs. The results highlighted the potentially important contributions of stress and decomposition mechanisms to biogenic SOA formation. Related field measurements elucidated the conditions when these factors could be important in the ambient environment. The project also revealed repeated the complexity of the stress/VOC emission relationship, and the difficulty in expressing these relationships in a comprehensive manner.« less

Correlations between chromatographic parameters and bioactivity predictors of potential herbicides.

PubMed

Janicka, Małgorzata

2014-08-01

Different liquid chromatography techniques, including reversed-phase liquid chromatography on Purosphere RP-18e, IAM.PC.DD2 and Cosmosil Cholester columns and micellar liqud chromatography with a Purosphere RP-8e column and using buffered sodium dodecyl sulfate-acetonitrile as the mobile phase, were applied to study the lipophilic properties of 15 newly synthesized phenoxyacetic and carbamic acid derivatives, which are potential herbicides. Chromatographic lipophilicity descriptors were used to extrapolate log k parameters (log kw and log km) and log k values. Partitioning lipophilicity descriptors, i.e., log P coefficients in an n-octanol-water system, were computed from the molecular structures of the tested compounds. Bioactivity descriptors, including partition coefficients in a water-plant cuticle system and water-human serum albumin and coefficients for human skin partition and permeation were calculated in silico by ACD/ADME software using the linear solvation energy relationship of Abraham. Principal component analysis was applied to describe similarities between various chromatographic and partitioning lipophilicities. Highly significant, predictive linear relationships were found between chromatographic parameters and bioactivity descriptors. © The Author [2013]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Memory recall in arousing situations - an emotional von Restorff effect?

PubMed

Wiswede, Daniel; Rüsseler, Jascha; Hasselbach, Simone; Münte, Thomas F

2006-07-24

Previous research has demonstrated a relationship between memory recall and P300 amplitude in list learning tasks, but the variables mediating this P300-recall relationship are not well understood. In the present study, subjects were required to recall items from lists consisting of 12 words, which were presented in front of pictures taken from the IAPS collection. One word per list is made distinct either by font color or by a highly arousing background IAPS picture. This isolation procedure was first used by von Restorff. Brain potentials were recorded during list presentation. Recall performance was enhanced for color but not for emotional isolates. Event-related brain potentials (ERP) showed a more positive P300-component for recalled non-isolated words and color-isolated words, compared to the respective non-remembered words, but not for words isolated by arousing background. Our findings indicate that it is crucial to take emotional mediator variables into account, when using the P300 to predict later recall. Highly arousing environments might force the cognitive system to interrupt rehearsal processes in working memory, which might benefit transfer into other, more stable memory systems. The impact of attention-capturing properties of arousing background stimuli is also discussed.

Source-sink interaction: a century old concept under the light of modern molecular systems biology.

PubMed

Chang, Tian-Gen; Zhu, Xin-Guang; Raines, Christine

2017-07-20

Many approaches to engineer source strength have been proposed to enhance crop yield potential. However, a well-co-ordinated source-sink relationship is required finally to realize the promised increase in crop yield potential in the farmer's field. Source-sink interaction has been intensively studied for decades, and a vast amount of knowledge about the interaction in different crops and under different environments has been accumulated. In this review, we first introduce the basic concepts of source, sink and their interactions, then summarize current understanding of how source and sink can be manipulated through both environmental control and genetic manipulations. We show that the source-sink interaction underlies the diverse responses of crops to the same perturbations and argue that development of a molecular systems model of source-sink interaction is required towards a rational manipulation of the source-sink relationship for increased yield. We finally discuss both bottom-up and top-down routes to develop such a model and emphasize that a community effort is needed for development of this model. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Global Assessment of Exploitable Surface Reservoir Storage under Climate Change

NASA Astrophysics Data System (ADS)

Liu, L.; Parkinson, S.; Gidden, M.; Byers, E.; Satoh, Y.; Riahi, K.

2016-12-01

Surface water reservoirs provide us with reliable water supply systems, hydropower generation, flood control, and recreation services. Reliable reservoirs can be robust measures for water security and can help smooth out challenging seasonal variability of river flows. Yet, reservoirs also cause flow fragmentation in rivers and can lead to flooding of upstream areas, thereby displacing existing land-uses and ecosystems. The anticipated population growth, land use and climate change in many regions globally suggest a critical need to assess the potential for appropriate reservoir capacity that can balance rising demands with long-term water security. In this research, we assessed exploitable reservoir potential under climate change and human development constraints by deriving storage-yield relationships for 235 river basins globally. The storage-yield relationships map the amount of storage capacity required to meet a given water demand based on a 30-year inflow sequence. Runoff data is simulated with an ensemble of Global Hydrological Models (GHMs) for each of five bias-corrected general circulation models (GCMs) under four climate change pathways. These data are used to define future 30-year inflows in each river basin for time period between 2010 and 2080. The calculated capacity is then combined with geographical information of environmental and human development exclusion zones to further limit the storage capacity expansion potential in each basin. We investigated the reliability of reservoir potentials across different climate change scenarios and Shared Socioeconomic Pathways (SSPs) to identify river basins where reservoir expansion will be particularly challenging. Preliminary results suggest large disparities in reservoir potential across basins: some basins have already approached exploitable reserves, while some others display abundant potential. Exclusions zones pose significant impact on the amount of actual exploitable storage and firm yields worldwide: 30% of reservoir potential would be unavailable because of land occupation by environmental and human development. Results from this study will help decision makers to understand the reliability of infrastructure systems particularly sensitive to future water availability.

A temporal interestingness measure for drug interaction signal detection in post-marketing surveillance.

PubMed

Ji, Yanqing; Ying, Hao; Tran, John; Dews, Peter; Mansour, Ayman; Massanari, R Michael

2014-01-01

Drug-drug interactions (DDIs) can result in serious consequences, including death. Existing methods for identifying potential DDIs in post-marketing surveillance primarily rely on the FDA's (Food and Drug Administration) spontaneous reporting system. However, this system suffers from severe underreporting, which makes it difficult to timely collect enough valid cases for statistical analysis. In this paper, we study how to signal potential DDIs using patient electronic health data. Specifically, we focus on discovery of potential DDIs by analyzing the temporal relationships between the concurrent use of two drugs of interest and the occurrences of various symptoms using novel temporal association mining techniques we developed. A new interestingness measure called functional temporal interest was proposed to assess the degrees of temporal association between two drugs of interest and each symptom. The measure was employed to screen potential DDIs from 21,405 electronic patient cases retrieved from the Veterans Affairs Medical Center in Detroit, Michigan. The preliminary results indicate the usefulness of our method in finding potential DDIs for further analysis (e.g., epidemiology study) and investigation (e.g., case review) by drug safety professionals.

A universal steady state I-V relationship for membrane current

NASA Technical Reports Server (NTRS)

Chernyak, Y. B.; Cohen, R. J. (Principal Investigator)

1995-01-01

A purely electrical mechanism for the gating of membrane ionic channel gives rise to a simple I-V relationship for membrane current. Our approach is based on the known presence of gating charge, which is an established property of the membrane channel gating. The gating charge is systematically treated as a polarization of the channel protein which varies with the external electric field and modifies the effective potential through which the ions migrate in the channel. Two polarization effects have been considered: 1) the up or down shift of the whole potential function, and 2) the change in the effective electric field inside the channel which is due to familiar effect of the effective reduction of the electric field inside a dielectric body because of the presence of surface charges on its surface. Both effects are linear in the channel polarization. The ionic current is described by a steady state solution of the Nernst-Planck equation with the potential directly controlled by the gating charge system. The solution describes reasonably well the steady state and peak-current I-V relationships for different channels, and when applied adiabatically, explains the time lag between the gating charge current and the rise of the ionic current. The approach developed can be useful as an effective way to model the ionic currents in axons, cardiac cells and other excitable tissues.

Continuous- and discrete-time stimulus sequences for high stimulus rate paradigm in evoked potential studies.

PubMed

Wang, Tao; Huang, Jiang-hua; Lin, Lin; Zhan, Chang'an A

2013-01-01

To obtain reliable transient auditory evoked potentials (AEPs) from EEGs recorded using high stimulus rate (HSR) paradigm, it is critical to design the stimulus sequences of appropriate frequency properties. Traditionally, the individual stimulus events in a stimulus sequence occur only at discrete time points dependent on the sampling frequency of the recording system and the duration of stimulus sequence. This dependency likely causes the implementation of suboptimal stimulus sequences, sacrificing the reliability of resulting AEPs. In this paper, we explicate the use of continuous-time stimulus sequence for HSR paradigm, which is independent of the discrete electroencephalogram (EEG) recording system. We employ simulation studies to examine the applicability of the continuous-time stimulus sequences and the impacts of sampling frequency on AEPs in traditional studies using discrete-time design. Results from these studies show that the continuous-time sequences can offer better frequency properties and improve the reliability of recovered AEPs. Furthermore, we find that the errors in the recovered AEPs depend critically on the sampling frequencies of experimental systems, and their relationship can be fitted using a reciprocal function. As such, our study contributes to the literature by demonstrating the applicability and advantages of continuous-time stimulus sequences for HSR paradigm and by revealing the relationship between the reliability of AEPs and sampling frequencies of the experimental systems when discrete-time stimulus sequences are used in traditional manner for the HSR paradigm.

Analyzing Impact Factors of Airport Taxiing Delay Based on Ads-B Data

NASA Astrophysics Data System (ADS)

Li, J.; Wang, X.; Xu, Y.; Li, Q.; He, C.; Li, Y.

2017-09-01

Identifying the factors that cause taxiing delay on airports is a prerequisite for optimizing aircraft taxiing schemes, and helps improve the efficiency of taxiing system. Few of current studies had quantified the potential influencing factors and further investigated their intrinsic relationship. In view of these problems, this paper uses ADS-B data to calculate taxiing delay time by restoring taxiing route and identifying key status points, and further analyzes the impact factors of airport taxiing delay by investigating the relationship between delay time and environmental data such as weather, wind, visibility etc. The case study in Guangzhou Baiyun Airport validates the effectiveness of the proposed method.

Obstructive sleep apnea and neurodegenerative diseases: A bidirectional relation

PubMed Central

Bahia, Christianne Martins Corrêa da Silva; Pereira, João Santos

2015-01-01

Sleep disorders are common during the clinical course of the main neurodegenerative diseases. Among these disorders, obstructive sleep apnea has been extensively studied in the last decade and recent knowledge regarding its relationship with the neurodegenerative process points a bidirectional relationship. Neurodegenerative diseases can lead to functional changes in the respiratory system that facilitate the emergence of apnea. On the other hand, obstructive sleep apnea itself can lead to acceleration of neuronal death due to intermittent hypoxia. Considering that obstructive sleep apnea is a potentially treatable condition, its early identification and intervention could have a positive impact on the management of patients with neurodegenerative diseases. PMID:29213936

From immunotoxicity to carcinogenicity: the effects of carbamate pesticides on the immune system.

PubMed

Dhouib, Ines; Jallouli, Manel; Annabi, Alya; Marzouki, Soumaya; Gharbi, Najoua; Elfazaa, Saloua; Lasram, Mohamed Montassar

2016-05-01

The immune system can be the target of many chemicals, with potentially severe adverse effects on the host's health. In the literature, carbamate (CM) pesticides have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate, or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulatory factors and modifying immune tolerance. In the present study, direct immunotoxicity, endocrine disruption and inhibition of esterases activities have been introduced as the main mechanisms of CMs-induced immune dysregulation. Moreover, the evidence on the relationship between CM pesticide exposure, dysregulation of the immune system and predisposition to different types of cancers, allergies, autoimmune and infectious diseases is criticized. In addition, in this review, we will discuss the relationship between immunotoxicity and cancer, and the advances made toward understanding the basis of cancer immune evasion.

Direct experimental determination of the topological winding number of skyrmions in Cu2OSeO3

NASA Astrophysics Data System (ADS)

Zhang, S. L.; van der Laan, G.; Hesjedal, T.

2017-02-01

The mathematical concept of topology has brought about significant advantages that allow for a fundamental understanding of the underlying physics of a system. In magnetism, the topology of spin order manifests itself in the topological winding number which plays a pivotal role for the determination of the emergent properties of a system. However, the direct experimental determination of the topological winding number of a magnetically ordered system remains elusive. Here, we present a direct relationship between the topological winding number of the spin texture and the polarized resonant X-ray scattering process. This relationship provides a one-to-one correspondence between the measured scattering signal and the winding number. We demonstrate that the exact topological quantities of the skyrmion material Cu2OSeO3 can be directly experimentally determined this way. This technique has the potential to be applicable to a wide range of materials, allowing for a direct determination of their topological properties.

The role of breast-feeding in infant immune system: a systems perspective on the intestinal microbiome.

PubMed

Praveen, Paurush; Jordan, Ferenc; Priami, Corrado; Morine, Melissa J

2015-09-24

The human intestinal microbiota changes from being sparsely populated and variable to possessing a mature, adult-like stable microbiome during the first 2 years of life. This assembly process of the microbiota can lead to either negative or positive effects on health, depending on the colonization sequence and diet. An integrative study on the diet, the microbiota, and genomic activity at the transcriptomic level may give an insight into the role of diet in shaping the human/microbiome relationship. This study aims at better understanding the effects of microbial community and feeding mode (breast-fed and formula-fed) on the immune system, by comparing intestinal metagenomic and transcriptomic data from breast-fed and formula-fed babies. We re-analyzed a published metagenomics and host gene expression dataset from a systems biology perspective. Our results show that breast-fed samples co-express genes associated with immunological, metabolic, and biosynthetic activities. The diversity of the microbiota is higher in formula-fed than breast-fed infants, potentially reflecting the weaker dependence of infants on maternal microbiome. We mapped the microbial composition and the expression patterns for host systems and studied their relationship from a systems biology perspective, focusing on the differences. Our findings revealed that there is co-expression of more genes in breast-fed samples but lower microbial diversity compared to formula-fed. Applying network-based systems biology approach via enrichment of microbial species with host genes revealed the novel key relationships of the microbiota with immune and metabolic activity. This was supported statistically by data and literature.

Making the case for a clinical information system: the chief information officer view.

PubMed

Cotter, Carole M

2007-03-01

Adequate decision support for clinicians and other caregivers requires accessible and reliable patient information. Powerful societal and economic forces are moving us toward an integrated, patient-centered health care information system that will allow caregivers to exchange up-to-date patient health information quickly and easily. These forces include patient safety, potential health care cost savings, empowerment of consumers (and their subsequent demands for quality), new federal policies, and growing regional health care initiatives. Underspending on health care information technologies has gone on for many years; and the creation and implementation of a comprehensive clinical information system will entail many difficulties, particularly in regard to patients' privacy and control of their information, standardization of electronic health records, cost of adopting information technology, unbalanced financial incentives, and the varying levels of preparation across caregivers. There will also be potential effects on the physician-patient relationship. Ultimately, an integrated system will require a concerted transformation of the health care industry that is akin to what the banking industry has accomplished with electronic automation. Critical care units provide a good starting point for how information system technologies can be used and electronic patient information collected, although the robust systems designed for intensive care units are not always used to their potential.

Outlining social physics for modern societies—locating culture, economics, and politics: The Enlightenment reconsidered

PubMed Central

Iberall, A. S.

1985-01-01

A groundwork is laid for a formulation of the modern human social system as a field continuum. As in a simple material physical field, the independent implied relationships of materials or processes in flux have to be based on local conservations of mass, energy, and momentum. In complex fields, the transport fluctuations of momentum are transformed into action modes (e.g., [unk] pdq = ΣHi = H, a characteristic quantum of action over a characteristic cycle time). In complex living systems, a fourth local conservation of population number, the demographic variable, has to be added as a renormalized variable. Modern man, settled in place via agriculture, urbanized, and engaged largely in trade and war, invents a fifth local conservation—value-in-trade, the economic variable. The potentials that drive these five fluxes are also enumerated. Among the more evident external and internal physical-chemical potentials, the driving potentials include a sheaf of internal potential-like components that represent the command-control system emergent as politics. In toto, culture represents the social solvent with the main processes of economics and politics being driven by a social pressure. PMID:16593594

Relationships between CO 2, thermodynamic limits on silicate weathering, and the strength of the silicate weathering feedback

DOE PAGES

Winnick, Matthew J.; Maher, Kate

2018-01-27

Recent studies have suggested that thermodynamic limitations on chemical weathering rates exert a first-order control on riverine solute fluxes and by extension, global chemical weathering rates. As such, these limitations may play a prominent role in the regulation of carbon dioxide levels (pCO 2) over geologic timescales by constraining the maximum global weathering flux. In this study, we develop a theoretical scaling relationship between equilibrium solute concentrations and pCO 2 based on equilibrium constants and reaction stoichiometry relating primary mineral dissolution and secondary mineral precipitation. Here, we test this theoretical scaling relationship against reactive transport simulations of chemical weathering profilesmore » under open-and closed-system conditions, representing partially and fully water-saturated regolith, respectively. Under open-system conditions, equilibrium bicarbonate concentrations vary as a power-law function of pCO 2(y =kx n)where nis dependent on reaction stoichiometry and kis dependent on both reaction stoichiometry and the equilibrium constant. Under closed-system conditions, bicarbonate concentrations vary linearly with pCO 2 at low values and approach open-system scaling at high pCO 2. To describe the potential role of thermodynamic limitations in the global silicate weathering feedback, we develop a new mathematical framework to assess weathering feedback strength in terms of both (1) steady-state atmospheric pCO 2 concentrations, and (2) susceptibility to secular changes in degassing rates and transient carbon cycle perturbations, which we term 1st and 2nd order feedback strength, respectively. Finally, we discuss the implications of these results for the effects of vascular land plant evolution on feedback strength, the potential role of vegetation in controlling modern solute fluxes, and the application of these frameworks to a more complete functional description of the silicate weathering feedback. Most notably, the dependence of equilibrium solute concentrations on pCO 2 may represent a direct weathering feedback largely independent of climate and modulated by belowground organic carbon respiration.« less

Relationships between CO 2, thermodynamic limits on silicate weathering, and the strength of the silicate weathering feedback

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winnick, Matthew J.; Maher, Kate

Recent studies have suggested that thermodynamic limitations on chemical weathering rates exert a first-order control on riverine solute fluxes and by extension, global chemical weathering rates. As such, these limitations may play a prominent role in the regulation of carbon dioxide levels (pCO 2) over geologic timescales by constraining the maximum global weathering flux. In this study, we develop a theoretical scaling relationship between equilibrium solute concentrations and pCO 2 based on equilibrium constants and reaction stoichiometry relating primary mineral dissolution and secondary mineral precipitation. Here, we test this theoretical scaling relationship against reactive transport simulations of chemical weathering profilesmore » under open-and closed-system conditions, representing partially and fully water-saturated regolith, respectively. Under open-system conditions, equilibrium bicarbonate concentrations vary as a power-law function of pCO 2(y =kx n)where nis dependent on reaction stoichiometry and kis dependent on both reaction stoichiometry and the equilibrium constant. Under closed-system conditions, bicarbonate concentrations vary linearly with pCO 2 at low values and approach open-system scaling at high pCO 2. To describe the potential role of thermodynamic limitations in the global silicate weathering feedback, we develop a new mathematical framework to assess weathering feedback strength in terms of both (1) steady-state atmospheric pCO 2 concentrations, and (2) susceptibility to secular changes in degassing rates and transient carbon cycle perturbations, which we term 1st and 2nd order feedback strength, respectively. Finally, we discuss the implications of these results for the effects of vascular land plant evolution on feedback strength, the potential role of vegetation in controlling modern solute fluxes, and the application of these frameworks to a more complete functional description of the silicate weathering feedback. Most notably, the dependence of equilibrium solute concentrations on pCO 2 may represent a direct weathering feedback largely independent of climate and modulated by belowground organic carbon respiration.« less

Relationships between CO2, thermodynamic limits on silicate weathering, and the strength of the silicate weathering feedback

NASA Astrophysics Data System (ADS)

Winnick, Matthew J.; Maher, Kate

2018-03-01

Recent studies have suggested that thermodynamic limitations on chemical weathering rates exert a first-order control on riverine solute fluxes and by extension, global chemical weathering rates. As such, these limitations may play a prominent role in the regulation of carbon dioxide levels (pCO2) over geologic timescales by constraining the maximum global weathering flux. In this study, we develop a theoretical scaling relationship between equilibrium solute concentrations and pCO2 based on equilibrium constants and reaction stoichiometry relating primary mineral dissolution and secondary mineral precipitation. We test this theoretical scaling relationship against reactive transport simulations of chemical weathering profiles under open- and closed-system conditions, representing partially and fully water-saturated regolith, respectively. Under open-system conditions, equilibrium bicarbonate concentrations vary as a power-law function of pCO2 (y = kxn) where n is dependent on reaction stoichiometry and k is dependent on both reaction stoichiometry and the equilibrium constant. Under closed-system conditions, bicarbonate concentrations vary linearly with pCO2 at low values and approach open-system scaling at high pCO2. To describe the potential role of thermodynamic limitations in the global silicate weathering feedback, we develop a new mathematical framework to assess weathering feedback strength in terms of both (1) steady-state atmospheric pCO2 concentrations, and (2) susceptibility to secular changes in degassing rates and transient carbon cycle perturbations, which we term 1st and 2nd order feedback strength, respectively. Finally, we discuss the implications of these results for the effects of vascular land plant evolution on feedback strength, the potential role of vegetation in controlling modern solute fluxes, and the application of these frameworks to a more complete functional description of the silicate weathering feedback. Most notably, the dependence of equilibrium solute concentrations on pCO2 may represent a direct weathering feedback largely independent of climate and modulated by belowground organic carbon respiration.

Discovering charge density functionals and structure-property relationships with PROPhet: A general framework for coupling machine learning and first-principles methods

DOE PAGES

Kolb, Brian; Lentz, Levi C.; Kolpak, Alexie M.

2017-04-26

Modern ab initio methods have rapidly increased our understanding of solid state materials properties, chemical reactions, and the quantum interactions between atoms. However, poor scaling often renders direct ab initio calculations intractable for large or complex systems. There are two obvious avenues through which to remedy this problem: (i) develop new, less expensive methods to calculate system properties, or (ii) make existing methods faster. This paper describes an open source framework designed to pursue both of these avenues. PROPhet (short for PROPerty Prophet) utilizes machine learning techniques to find complex, non-linear mappings between sets of material or system properties. Themore » result is a single code capable of learning analytical potentials, non-linear density functionals, and other structure-property or property-property relationships. These capabilities enable highly accurate mesoscopic simulations, facilitate computation of expensive properties, and enable the development of predictive models for systematic materials design and optimization. Here, this work explores the coupling of machine learning to ab initio methods through means both familiar (e.g., the creation of various potentials and energy functionals) and less familiar (e.g., the creation of density functionals for arbitrary properties), serving both to demonstrate PROPhet’s ability to create exciting post-processing analysis tools and to open the door to improving ab initio methods themselves with these powerful machine learning techniques.« less

Discovering charge density functionals and structure-property relationships with PROPhet: A general framework for coupling machine learning and first-principles methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolb, Brian; Lentz, Levi C.; Kolpak, Alexie M.

Modern ab initio methods have rapidly increased our understanding of solid state materials properties, chemical reactions, and the quantum interactions between atoms. However, poor scaling often renders direct ab initio calculations intractable for large or complex systems. There are two obvious avenues through which to remedy this problem: (i) develop new, less expensive methods to calculate system properties, or (ii) make existing methods faster. This paper describes an open source framework designed to pursue both of these avenues. PROPhet (short for PROPerty Prophet) utilizes machine learning techniques to find complex, non-linear mappings between sets of material or system properties. Themore » result is a single code capable of learning analytical potentials, non-linear density functionals, and other structure-property or property-property relationships. These capabilities enable highly accurate mesoscopic simulations, facilitate computation of expensive properties, and enable the development of predictive models for systematic materials design and optimization. Here, this work explores the coupling of machine learning to ab initio methods through means both familiar (e.g., the creation of various potentials and energy functionals) and less familiar (e.g., the creation of density functionals for arbitrary properties), serving both to demonstrate PROPhet’s ability to create exciting post-processing analysis tools and to open the door to improving ab initio methods themselves with these powerful machine learning techniques.« less

Towards an integrated understanding of gut microbiota using insects as model systems.

PubMed

Pernice, Mathieu; Simpson, Stephen J; Ponton, Fleur

2014-10-01

Metazoans form symbioses with microorganisms that synthesize essential nutritional compounds and increase their efficiency to digest and absorb nutrients. Despite the growing awareness that microbes within the gut play key roles in metabolism, health and development of metazoans, symbiotic relationships within the gut are far from fully understood. Insects, which generally harbor a lower microbial diversity than vertebrates, have recently emerged as potential model systems to study these interactions. In this review, we give a brief overview of the characteristics of the gut microbiota in insects in terms of low diversity but high variability at intra- and interspecific levels and we investigate some of the ecological and methodological factors that might explain such variability. We then emphasize how studies integrating an array of techniques and disciplines have the potential to provide new understanding of the biology of this micro eco-system. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

Retrieving hydrological connectivity from empirical causality in karst systems

NASA Astrophysics Data System (ADS)

Delforge, Damien; Vanclooster, Marnik; Van Camp, Michel; Poulain, Amaël; Watlet, Arnaud; Hallet, Vincent; Kaufmann, Olivier; Francis, Olivier

2017-04-01

Because of their complexity, karst systems exhibit nonlinear dynamics. Moreover, if one attempts to model a karst, the hidden behavior complicates the choice of the most suitable model. Therefore, both intense investigation methods and nonlinear data analysis are needed to reveal the underlying hydrological connectivity as a prior for a consistent physically based modelling approach. Convergent Cross Mapping (CCM), a recent method, promises to identify causal relationships between time series belonging to the same dynamical systems. The method is based on phase space reconstruction and is suitable for nonlinear dynamics. As an empirical causation detection method, it could be used to highlight the hidden complexity of a karst system by revealing its inner hydrological and dynamical connectivity. Hence, if one can link causal relationships to physical processes, the method should show great potential to support physically based model structure selection. We present the results of numerical experiments using karst model blocks combined in different structures to generate time series from actual rainfall series. CCM is applied between the time series to investigate if the empirical causation detection is consistent with the hydrological connectivity suggested by the karst model.

Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome

PubMed Central

Audouze, Karine; Tromelin, Anne; Le Bon, Anne Marie; Belloir, Christine; Petersen, Rasmus Koefoed; Kristiansen, Karsten; Brunak, Søren; Taboureau, Olivier

2014-01-01

The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors (hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant molecules have been made, screening the olfactory repertoire of hORs remains a tremendous challenge. We therefore developed a chemical systems level approach based on protein-protein association network to investigate novel hOR-odorant relationships. Using this new approach, we proposed and validated new bioactivities for odorant molecules and OR2W1, OR51E1 and OR5P3. As it remains largely unknown how human perception of odorants influence or prevent diseases, we also developed an odorant-protein matrix to explore global relationships between chemicals, biological targets and disease susceptibilities. We successfully experimentally demonstrated interactions between odorants and the cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor gamma (PPARγ). Overall, these results illustrate the potential of integrative systems chemical biology to explore the impact of odorant molecules on human health, i.e. human odorome. PMID:24695519

Potentially bioavailable natural organic carbon and hydrolyzable amino acids in aquifer sediments

USGS Publications Warehouse

Thomas, Lashun K.; Widdowson, Mark A.; Novak, John T.; Chapelle, Francis H.; Benner, Ronald; Kaiser, Karl

2012-01-01

This study evaluated the relationship between concentrations of operationally defined potentially bioavailable organic -carbon (PBOC) and hydrolyzable amino acids (HAAs) in sediments collected from a diverse range of chloroethene--contaminated sites. Concentrations of PBOC and HAA were measured using aquifer sediment samples collected at six selected study sites. Average concentrations of total HAA and PBOC ranged from 1.96 ± 1.53 to 20.1 ± 25.6 mg/kg and 4.72 ± 0.72 to 443 ± 65.4 mg/kg, respectively. Results demonstrated a statistically significant positive relationship between concentrations of PBOC and total HAA present in the aquifer sediment (p < 0.05). Higher levels of HAA were consistently observed at sites with greater levels of PBOC and first-order decay rates. Because amino acids are known to be readily biodegradable carbon compounds, this relationship suggests that the sequential chemical extraction procedure used to measure PBOC is a useful indicator of bioavailable carbon in aquifer sediments. This, in turn, is consistent with the interpretation that PBOC measurements can be used for estimating the amount of natural organic carbon available for driving the reductive dechlorination of chloroethenes in groundwater systems.

Root canal treatment and general health: a review of the literature.

PubMed

Murray, C A; Saunders, W P

2000-01-01

The focal infection theory was prominent in the medical literature during the early 1900s and curtailed the progress of endodontics. This theory proposed that microorganisms, or their toxins, arising from a focus of circumscribed infection within a tissue could disseminate systemically, resulting in the initiation or exacerbation of systemic illness or the damage of a distant tissue site. For example, during the focal infection era rheumatoid arthritis (RA) was identified as having a close relationship with dental health. The theory was eventually discredited because there was only anecdotal evidence to support its claims and few scientifically controlled studies. There has been a renewed interest in the influence that foci of infection within the oral tissues may have on general health. Some current research suggests a possible relationship between dental health and cardiovascular disease and published case reports have cited dental sources as causes for several systemic illnesses. Improved laboratory procedures employing sophisticated molecular biological techniques and enhanced culturing techniques have allowed researchers to confirm that bacteria recovered from the peripheral blood during root canal treatment originated in the root canal. It has been suggested that the bacteraemia, or the associated bacterial endotoxins, subsequent to root canal treatment, may cause potential systemic complications. Further research is required, however, using current sampling and laboratory methods from scientifically controlled population groups to determine if a significant relationship between general health and periradicular infection exists.

Measuring adult attachment representation in an fMRI environment: concepts and assessment.

PubMed

Buchheim, Anna; George, Carol; Kachele, Horst; Erk, Susanne; Walter, Henrik

2006-01-01

Human attachment is defined as a biologically based behavioral system that influences motivational, cognitive, emotional, and memory processes with respect to intimate relationships (parents, life partner, own children). Recent neurobiological studies in this field have in common that they investigated social relationships by examining fMRI neuroimaging patterns while individuals viewed pictures of their beloved relationship partner versus friends, acquaintances, strangers, or mothers' responses to their young children. The researchers showed that the neural underpinnings of these unique intimate emotional states are linked to functionally specialized areas in the brain. Conceptualizing this work from a behavioral systems-attachment theory perspective, these studies did not directly address the subject's attachment representational system. Traditional attachment theory and research has been built on the analysis of attachment narratives, called 'attachment representation'. The Adult Attachment Projective developed by George and West in 2001 is a set of attachment-based schematic pictures. It is constructed to increasingly activate the participant's attachment system in the course of the task, that is, by the introduction of increasingly stressful attachment scenes concluding with pictures of individuals facing death and potential abuse alone. The attachment patterns are evaluated based on individuals' overall verbal response to the picture set. This paper proposes that the AAP is a fruitful measure to use in an fMRI environment to examine brain activation patterns in adults while they are speaking overtly about attachment stories in a standardized setting.

Value as a parameter to consider in operational strategies for CSP plants

NASA Astrophysics Data System (ADS)

de Meyer, Oelof; Dinter, Frank; Govender, Saneshan

2017-06-01

This paper introduced a value parameter to consider when analyzing operational strategies for CSP plants. The electric system in South Africa, used as case study, is severely constrained with an influx of renewables in the early phase of deployment. The energy demand curve for the system is analyzed showing the total wind and solar photovoltaic contributions for winter and summer. Due to the intermittent nature and meteorological operating conditions of wind and solar photovoltaic plants, the value of CSP plants within the electric system is introduced. Analyzing CSP plants based on the value parameter alone will remain only a philosophical view. Currently there is no quantifiable measure to translate the philosophical view or subjective value and it solely remains the position of the stakeholder. By introducing three other parameters, Cost, Plant and System to a holistic representation of the Operating Strategies of generation plants, the Value parameter can be translated into a quantifiable measure. Utilizing the country's current procurement program as case study, CSP operating under the various PPA within the Bid Windows are analyzed. The Value Cost Plant System diagram developed is used to quantify the value parameter. This paper concluded that no value is obtained from CSP plants operating under the Bid Window 1 & 2 Power Purchase Agreement. However, by recognizing the dispatchability potential of CSP plants in Bid Window 3 & 3.5, the value of CSP in the electric system can be quantified utilizing Value Added Relationship VCPS-diagram. Similarly ancillary services to the system were analyzed. One of the relationships that have not yet been explored within the industry is an interdependent relationship. It was emphasized that the cost and value structure is shared between the plant and system. Although this relationship is functional when the plant and system belongs to the same entity, additional value is achieved by marginalizing the cost structure. A tradeoff between the plant performance indicators and system operations are achieved. CSP plants have demonstrated its capabilities by adapting to various operating strategies. With adequate storage capabilities and appropriate system boundary conditions in place, CSP plants offer solutions as base-load generation plants, peaking plants, intermittent generation and ancillary services to the system. Depending on the electric system structure, the value obtained from CSP plants are quantifiable under the right boundary conditions. An interdependent relationship between the plant and system attains the most value in operating strategies for CSP.

A Systems Approach to Vaccine Decision Making

PubMed Central

Lee, Bruce Y.; Mueller, Leslie E.; Tilchin, Carla G.

2016-01-01

Vaccines reside in a complex multiscale system that includes biological, clinical, behavioral, social, operational, environmental, and economical relationships. Not accounting for these systems when making decisions about vaccines can result in changes that have little effect rather than solutions, lead to unsustainable solutions, miss indirect (e.g., secondary, tertiary, and beyond) effects, cause unintended consequences, and lead to wasted time, effort, and resources. Mathematical and computational modeling can help better understand and address complex systems by representing all or most of the components, relationships, and processes. Such models can serve as “virtual laboratories” to examine how a system operates and test the effects of different changes within the system. Here are ten lessons learned from using computational models to bring more of a systems approach to vaccine decision making: (i) traditional single measure approaches may overlook opportunities; (ii) there is complex interplay among many vaccine, population, and disease characteristics; (iii) accounting for perspective can identify synergies; (iv) the distribution system should not be overlooked; (v) target population choice can have secondary and tertiary effects; (vi) potentially overlooked characteristics can be important; (vii) characteristics of one vaccine can affect other vaccines; (viii) the broader impact of vaccines is complex; (ix) vaccine administration extends beyond the provider level; (x) and the value of vaccines is dynamic. PMID:28017430

A systems approach to vaccine decision making.

PubMed

Lee, Bruce Y; Mueller, Leslie E; Tilchin, Carla G

2017-01-20

Vaccines reside in a complex multiscale system that includes biological, clinical, behavioral, social, operational, environmental, and economical relationships. Not accounting for these systems when making decisions about vaccines can result in changes that have little effect rather than solutions, lead to unsustainable solutions, miss indirect (e.g., secondary, tertiary, and beyond) effects, cause unintended consequences, and lead to wasted time, effort, and resources. Mathematical and computational modeling can help better understand and address complex systems by representing all or most of the components, relationships, and processes. Such models can serve as "virtual laboratories" to examine how a system operates and test the effects of different changes within the system. Here are ten lessons learned from using computational models to bring more of a systems approach to vaccine decision making: (i) traditional single measure approaches may overlook opportunities; (ii) there is complex interplay among many vaccine, population, and disease characteristics; (iii) accounting for perspective can identify synergies; (iv) the distribution system should not be overlooked; (v) target population choice can have secondary and tertiary effects; (vi) potentially overlooked characteristics can be important; (vii) characteristics of one vaccine can affect other vaccines; (viii) the broader impact of vaccines is complex; (ix) vaccine administration extends beyond the provider level; and (x) the value of vaccines is dynamic. Copyright © 2016 Elsevier Ltd. All rights reserved.

Relationship between field-aligned currents and inverted-V parallel potential drops observed at midaltitudes

NASA Astrophysics Data System (ADS)

Sakanoi, T.; Fukunishi, H.; Mukai, T.

1995-10-01

The inverted-V field-aligned acceleration region existing in the altitude range of several thousand kilometers plays an essential role for the magnetosphere-ionosphere coupling system. The adiabatic plasma theory predicts a linear relationship between field-aligned current density (J∥) and parallel potential drop (Φ∥), that is, J∥=KΦ∥, where K is the field-aligned conductance. We examined this relationship using the charged particle and magnetic field data obtained from the Akebono (Exos D) satellite. The potential drop above the satellite was derived from the peak energy of downward electrons, while the potential drop below the satellite was derived from two different methods: the peak energy of upward ions and the energy-dependent widening of electron loss cone. On the other hand, field-aligned current densities in the inverted-V region were estimated from the Akebono magnetometer data. Using these potential drops and field-aligned current densities, we estimated the linear field-aligned conductance KJΦ. Further, we obtained the corrected field-aligned conductance KCJΦ by applying the full Knight's formula to the current-voltage relationship. We also independently estimated the field-aligned conductance KTN from the number density and the thermal temperature of magnetospheric source electrons which were obtained by fitting accelerated Maxwellian functions for precipitating electrons. The results are summarized as follows: (1) The latitudinal dependence of parallel potential drops is characterized by a narrow V-shaped structure with a width of 0.4°-1.0°. (2) Although the inverted-V potential region exactly corresponds to the upward field aligned current region, the latitudinal dependence of upward current intensity is an inverted-U shape rather than an inverted-V shape. Thus it is suggested that the field-aligned conductance KCJΦ changes with a V-shaped latitudinal dependence. In many cases, KCJΦ values at the edge of the inverted-V region are about 5-10 times larger than those at the center. (3) By comparing KCJΦ with KTN, KCJΦ is found to be about 2-20 times larger than KTN. These results suggest that low-energy electrons such as trapped electrons, secondary and back-scattered electrons, and ionospheric electrons significantly contribute to upward field-aligned currents in the inverted-V region. It is therefore inferred that non adiabatic pitch angle scattering processes play an important role in the inverted-V region. .

Development and Application of Computational/In Vitro Toxicological Methods for Chemical Hazard Risk Reduction of New Materials for Advanced Weapon Systems

NASA Technical Reports Server (NTRS)

Frazier, John M.; Mattie, D. R.; Hussain, Saber; Pachter, Ruth; Boatz, Jerry; Hawkins, T. W.

2000-01-01

The development of quantitative structure-activity relationship (QSAR) is essential for reducing the chemical hazards of new weapon systems. The current collaboration between HEST (toxicology research and testing), MLPJ (computational chemistry) and PRS (computational chemistry, new propellant synthesis) is focusing R&D efforts on basic research goals that will rapidly transition to useful products for propellant development. Computational methods are being investigated that will assist in forecasting cellular toxicological end-points. Models developed from these chemical structure-toxicity relationships are useful for the prediction of the toxicological endpoints of new related compounds. Research is focusing on the evaluation tools to be used for the discovery of such relationships and the development of models of the mechanisms of action. Combinations of computational chemistry techniques, in vitro toxicity methods, and statistical correlations, will be employed to develop and explore potential predictive relationships; results for series of molecular systems that demonstrate the viability of this approach are reported. A number of hydrazine salts have been synthesized for evaluation. Computational chemistry methods are being used to elucidate the mechanism of action of these salts. Toxicity endpoints such as viability (LDH) and changes in enzyme activity (glutahoione peroxidase and catalase) are being experimentally measured as indicators of cellular damage. Extrapolation from computational/in vitro studies to human toxicity, is the ultimate goal. The product of this program will be a predictive tool to assist in the development of new, less toxic propellants.

Patients' acceptance towards a web-based personal health record system: an empirical study in Taiwan.

PubMed

Liu, Chung-Feng; Tsai, Yung-Chieh; Jang, Fong-Lin

2013-10-17

The health care sector has become increasingly interested in developing personal health record (PHR) systems as an Internet-based telehealthcare implementation to improve the quality and decrease the cost of care. However, the factors that influence patients' intention to use PHR systems remain unclear. Based on physicians' therapeutic expertise, we implemented a web-based infertile PHR system and proposed an extended Technology Acceptance Model (TAM) that integrates the physician-patient relationship (PPR) construct into TAM's original perceived ease of use (PEOU) and perceived usefulness (PU) constructs to explore which factors will influence the behavioral intentions (BI) of infertile patients to use the PHR. From ninety participants from a medical center, 50 valid responses to a self-rating questionnaire were collected, yielding a response rate of 55.56%. The partial least squares (PLS) technique was used to assess the causal relationships that were hypothesized in the extended model. The results indicate that infertile patients expressed a moderately high intention to use the PHR system. The PPR and PU of patients had significant effects on their BI to use PHR, whereas the PEOU indirectly affected the patients' BI through the PU. This investigation confirms that PPR can have a critical role in shaping patients' perceptions of the use of healthcare information technologies. Hence, we suggest that hospitals should promote the potential usefulness of PHR and improve the quality of the physician-patient relationship to increase patients' intention of using PHR.

Patients’ Acceptance towards a Web-Based Personal Health Record System: An Empirical Study in Taiwan

PubMed Central

Liu, Chung-Feng; Tsai, Yung-Chieh; Jang, Fong-Lin

2013-01-01

The health care sector has become increasingly interested in developing personal health record (PHR) systems as an Internet-based telehealthcare implementation to improve the quality and decrease the cost of care. However, the factors that influence patients’ intention to use PHR systems remain unclear. Based on physicians’ therapeutic expertise, we implemented a web-based infertile PHR system and proposed an extended Technology Acceptance Model (TAM) that integrates the physician-patient relationship (PPR) construct into TAM’s original perceived ease of use (PEOU) and perceived usefulness (PU) constructs to explore which factors will influence the behavioral intentions (BI) of infertile patients to use the PHR. From ninety participants from a medical center, 50 valid responses to a self-rating questionnaire were collected, yielding a response rate of 55.56%. The partial least squares (PLS) technique was used to assess the causal relationships that were hypothesized in the extended model. The results indicate that infertile patients expressed a moderately high intention to use the PHR system. The PPR and PU of patients had significant effects on their BI to use PHR, whereas the PEOU indirectly affected the patients’ BI through the PU. This investigation confirms that PPR can have a critical role in shaping patients’ perceptions of the use of healthcare information technologies. Hence, we suggest that hospitals should promote the potential usefulness of PHR and improve the quality of the physician-patient relationship to increase patients’ intention of using PHR. PMID:24142185

Women's hair as a cue to desired relationship and parenting characteristics.

PubMed

Matz, David C; Hinsz, Verlin B

2017-10-30

We investigated how women's hair color (blond, brown, black) and length (short, medium, long) influences males' judgments about the women's age, health, physical attractiveness, relationship potential, and parenting capability. Results, which are generally consistent with evolutionary psychology approaches, indicate that hair color and, to a lesser extent, length can affect perceptions of personal characteristics. More specifically, we found that lighter hair (blond and brown) compared to darker hair (black) is generally associated with perceptions of youth, health and attractiveness, and generally leads to more positive perceptions of relationship and parenting potential. Furthermore, the relationships between variables suggest that characteristics directly related to reproductive potential may be inferred from more obvious indirect characteristics. These results suggest that males are able to make complex judgments about women concerning their desirable relationship and parenting potential based on discernable characteristics such as hair color and length.

The Microbiome and Complement Activation: A Mechanistic Model for Preterm Birth

PubMed Central

Dunn, Alexis B.; Dunlop, Anne L.; Hogue, Carol J.; Miller, Andrew; Corwin, Elizabeth J.

2018-01-01

Preterm Birth (PTB, < 37 completed weeks' gestation) is one of the leading obstetrical problems in the United States affecting approximately 1 of every 9 births. Even more concerning are the persistent racial disparities in PTB with particularly high rates in African Americans. There are several recognized pathophysiologic pathways to PTB, including infection and/or exaggerated systemic or local inflammation. Intrauterine infection is a causal factor linked to PTB, thought to result most commonly from inflammatory processes triggered by microbial invasion of bacteria ascending from the vaginal microbiome. Trials to treat various infections have shown limited efficacy in reducing PTB risk, suggesting that other complex mechanisms, including those associated with inflammation, may be involved in the relationship between microbes, infection, and PTB. A key mediator of the inflammatory response, and recently shown to be associated with PTB, is the complement system, an innate defense mechanism involved in both normal physiologic processes that occur during pregnancy implantation, as well as processes that promote the elimination of pathogenic microbes. The purpose of this paper is to present a mechanistic model of inflammation-associated PTB, which hypothesizes a relationship between the microbiome and dysregulation of the complement system. Exploring the relationships between the microbial environment and complement biomarkers may elucidate a potentially modifiable biological pathway to preterm birth. PMID:28073296

University-Industry Relationships: Benefits and Risks

ERIC Educational Resources Information Center

Sandelin, Jon

2010-01-01

University-industry relationships can bring significant benefits to the university, the company and the individual researcher, but there is also the potential for risks to all parties. This paper presents the potential rewards and risks from university-industry relationships and the related opportunities for economic growth and job creation. The…

Moving beyond Fuzy Altruism in Business-Education Relationships: The Potential of the Georgia Alliance for Public Education. Supporting Leaders for Tomorrow, Occasional Paper #8.

ERIC Educational Resources Information Center

Trimble, Grace

Georgia's business leadership is concerned about that state's public education system which has consistently ranked near the bottom of the educational ladder. In 1986, the Quality Basic Education (QBE) Act became law, and its provisions are described in this document. The Georgia Alliance for Public Education (the Alliance) was mobilized to…

GIS -- Is it a money pit or a profit generator?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutton, R.H.

1997-02-01

Today, new technologies including smart pigs and GPS technology can be used to expedite data collection and improve the accuracy of the GIS applications. Eventually, such applications as pipe information for a taxing district, corrosion testing history, and many other applications can be accommodated in a GIS system. The accompanying figure shows the potential relationship of various technologies in today`s world along with other automated data input sources such as very smart pigs and the Global Positioning System (GPS). The paper discusses implementation barriers, assuring success, and recommendations.

NASA Langley Systems Analysis & Concepts Directorate Technology Assessment/Portfolio Analysis

NASA Technical Reports Server (NTRS)

Cavanaugh, Stephen; Chytka, Trina; Arcara, Phil; Jones, Sharon; Stanley, Doug; Wilhite, Alan W.

2006-01-01

Systems analysis develops and documents candidate mission and architectures, associated system concepts, enabling capabilities and investment strategies to achieve NASA s strategic objectives. The technology assessment process connects the mission and architectures to the investment strategies. In order to successfully implement a technology assessment, there is a need to collect, manipulate, analyze, document, and disseminate technology-related information. Information must be collected and organized on the wide variety of potentially applicable technologies, including: previous research results, key technical parameters and characteristics, technology readiness levels, relationships to other technologies, costs, and potential barriers and risks. This information must be manipulated to facilitate planning and documentation. An assessment is included of the programmatic and technical risks associated with each technology task as well as potential risk mitigation plans. Risks are assessed and tracked in terms of likelihood of the risk occurring and consequences of the risk if it does occur. The risk assessments take into account cost, schedule, and technical risk dimensions. Assessment data must be simplified for presentation to decision makers. The Systems Analysis and Concepts Directorate (SACD) at NASA Langley Research Center has a wealth of experience in performing Technology Assessment and Portfolio Analysis as this has been a business line since 1978.

TRPM channels phosphorylation as a potential bridge between old signals and novel regulatory mechanisms of insulin secretion.

PubMed

Diaz-Garcia, Carlos Manlio; Sanchez-Soto, Carmen; Hiriart, Marcia

2013-03-01

Transient receptor potential channels, especially the members of the melastatin family (TRPM), participate in insulin secretion. Some of them are substrates for protein kinases, which are involved in several neurotransmitter, incretin and hormonal signaling cascades in β cells. The functional relationships between protein kinases and TRPM channels in systems of heterologous expression and native tissues rise issues about novel regulation pathways of pancreatic β-cell excitability. The aim of the present work is to review the evidences about phosphorylation of TRPM channels in β cells and to discuss the perspectives on insulin secretion.

Modelling formulations using gene expression programming--a comparative analysis with artificial neural networks.

PubMed

Colbourn, E A; Roskilly, S J; Rowe, R C; York, P

2011-10-09

This study has investigated the utility and potential advantages of gene expression programming (GEP)--a new development in evolutionary computing for modelling data and automatically generating equations that describe the cause-and-effect relationships in a system--to four types of pharmaceutical formulation and compared the models with those generated by neural networks, a technique now widely used in the formulation development. Both methods were capable of discovering subtle and non-linear relationships within the data, with no requirement from the user to specify the functional forms that should be used. Although the neural networks rapidly developed models with higher values for the ANOVA R(2) these were black box and provided little insight into the key relationships. However, GEP, although significantly slower at developing models, generated relatively simple equations describing the relationships that could be interpreted directly. The results indicate that GEP can be considered an effective and efficient modelling technique for formulation data. Copyright © 2011 Elsevier B.V. All rights reserved.

Potential Release Site Sediment Concentrations Correlated to Storm Water Station Runoff through GIS Modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

C.T. McLean

2005-06-01

This research examined the relationship between sediment sample data taken at Potential Release Sites (PRSs) and storm water samples taken at selected sites in and around Los Alamos National Laboratory (LANL). The PRSs had been evaluated for erosion potential and a matrix scoring system implemented. It was assumed that there would be a stronger relationship between the high erosion PRSs and the storm water samples. To establish the relationship, the research was broken into two areas. The first area was raster-based modeling, and the second area was data analysis utilizing the raster based modeling results and the sediment and stormmore » water sample results. Two geodatabases were created utilizing raster modeling functions and the Arc Hydro program. The geodatabase created using only Arc Hydro functions contains very fine catchment drainage areas in association with the geometric network and can be used for future contaminant tracking. The second geodatabase contains sub-watersheds for all storm water stations used in the study along with a geometric network. The second area of the study focused on data analysis. The analytical sediment data table was joined to the PRSs spatial data in ArcMap. All PRSs and PRSs with high erosion potential were joined separately to create two datasets for each of 14 analytes. Only the PRSs above the background value were retained. The storm water station spatial data were joined to the table of analyte values that were either greater than the National Pollutant Discharge Elimination System (NPDES) Multi-Sector General Permit (MSGP) benchmark value, or the Department of Energy (DOE) Drinking Water Defined Contribution Guideline (DWDCG). Only the storm water stations were retained that had sample values greater than the NPDES MSGP benchmark value or the DOE DWDCG. Separate maps were created for each analyte showing the sub-watersheds, the PRSs over background, and the storm water stations greater than the NPDES MSGP benchmark value or the DOE DWDCG. Tables were then created for each analyte that listed the PRSs average value by storm water station allowing a tabular view of the mapped data. The final table that was created listed the number of high erosion PRSs and regular PRSs over background values that were contained in each watershed. An overall relationship between the high erosion PRSs or the regular PRSs and the storm water stations was not identified through the methods used in this research. However, the Arc Hydro data models created for this analysis were used to track possible sources of contamination found through sampling at the storm water gaging stations. This geometric network tracing was used to identify possible relationships between the storm water stations and the PRSs. The methods outlined for the geometric network tracing could be used to find other relationships between the sites. A cursory statistical analysis was performed which could be expanded and applied to the data sets generated during this research to establish a broader relationship between the PRSs and storm water stations.« less

Cancer and Cancer-Related Fatigue and the Interrelationships With Depression, Stress, and Inflammation

PubMed Central

Weber, Daniel; O’Brien, Kylie

2016-01-01

Cancer-related fatigue (CRF) is a common symptom experienced in cancer patients. Depression, anxiety, and stress are associated with cancer. Depression and anxiety are also associated with CRF. At the cellular level, much is known about the impact of stress on the body generally, and its potential role in cancer. Stress, anxiety, and depression have been found to depress the immune system. Depression and stress have also been found to create inflammatory changes in the body and there is emerging evidence that inflammation is involved in cancer pathogenesis and in CRF. This article examines the relationships between stress, anxiety, depression, and cancer; relationships between anxiety and depression and CRF; and what happens at the cellular level, including impact on the immune system and emerging evidence of the role of inflammation in CRF. It also reports on research in relation to some Chinese herbal medicines that may be used to treat CRF.

Can a customer relationship management program improve recruitment for primary care research studies?

PubMed

Johnston, Sharon; Wong, Sabrina T; Blackman, Stephanie; Chau, Leena W; Grool, Anne M; Hogg, William

2017-11-16

Recruiting family physicians into primary care research studies requires researchers to continually manage information coming in, going out, and coming in again. In many research groups, Microsoft Excel and Access are the usual data management tools, but they are very basic and do not support any automation, linking, or reminder systems to manage and integrate recruitment information and processes. We explored whether a commercial customer relationship management (CRM) software program - designed for sales people in businesses to improve customer relations and communications - could be used to make the research recruitment system faster, more effective, and more efficient. We found that while there was potential for long-term studies, it simply did not adapt effectively enough for our shorter study and recruitment budget. The amount of training required to master the software and our need for ongoing flexible and timely support were greater than the benefit of using CRM software for our study.

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing.

PubMed

Farley, Toni; Kiefer, Jeff; Lee, Preston; Von Hoff, Daniel; Trent, Jeffrey M; Colbourn, Charles; Mousses, Spyro

2013-01-01

Breakthroughs in molecular profiling technologies are enabling a new data-intensive approach to biomedical research, with the potential to revolutionize how we study, manage, and treat complex diseases. The next great challenge for clinical applications of these innovations will be to create scalable computational solutions for intelligently linking complex biomedical patient data to clinically actionable knowledge. Traditional database management systems (DBMS) are not well suited to representing complex syntactic and semantic relationships in unstructured biomedical information, introducing barriers to realizing such solutions. We propose a scalable computational framework for addressing this need, which leverages a hypergraph-based data model and query language that may be better suited for representing complex multi-lateral, multi-scalar, and multi-dimensional relationships. We also discuss how this framework can be used to create rapid learning knowledge base systems to intelligently capture and relate complex patient data to biomedical knowledge in order to automate the recovery of clinically actionable information.

Organic unity theory: an integrative mind-body theory for psychiatry.

PubMed

Goodman, A

1997-12-01

The potential of psychiatry as an integrative science has been impeded by an internal schism that derives from the duality of mental and physical. Organic unity theory is proposed as a conceptual framework that brings together the terms of the mind-body duality in one coherent perspective. Organic unity theory is braided of three strands: identity, which describes the relationship between mentally described events and corresponding physically described events; continuity, which describes the linguistic-conceptual system that contains both mental and physical terms; and dialectic, which describes the relationship between the empirical way of knowing that is associated with the physical domain of the linguistic-conceptual system and the hermeneutic way of knowing that is associated with the mental domain. Each strand represents an integrative formulation that resolves an aspect of mental-physical dualism into an underlying unity. After the theory is presented, its implications for psychiatry are briefly considered.

The pathogenesis of Hirschsprung's disease-associated enterocolitis.

PubMed

Austin, Kelly Miller

2012-11-01

Hirschsprung's disease-associated enterocolitis (HAEC) remains the most life-threatening complication in Hirschsprung disease (HD) patients. The pathogenesis of HAEC has not been determined and many hypotheses regarding the etiology of HAEC have been proposed. These include a possible causal relationship between the abnormal enteric nervous system development in HD and the development of enterocolitis. Based on the complex genetic causes of HD that have been discovered and the resultant heterogeneous group of patients that exists, the causes of HAEC are likely multiple. New insights regarding the relationship of the role of the enteric nervous system and its interaction between intestinal barrier function, innate host immunity, and commensal microflora have been discovered, which may shed light on this perplexing problem. This review presents current known risk factors of HAEC and the proposed theories and supporting evidence for the potential etiologies of HAEC. Copyright © 2012. Published by Elsevier Inc.

Early-Stage Visual Processing and Cortical Amplification Deficits in Schizophrenia

PubMed Central

Butler, Pamela D.; Zemon, Vance; Schechter, Isaac; Saperstein, Alice M.; Hoptman, Matthew J.; Lim, Kelvin O.; Revheim, Nadine; Silipo, Gail; Javitt, Daniel C.

2005-01-01

Background Patients with schizophrenia show deficits in early-stage visual processing, potentially reflecting dysfunction of the magnocellular visual pathway. The magnocellular system operates normally in a nonlinear amplification mode mediated by glutamatergic (N-methyl-d-aspartate) receptors. Investigating magnocellular dysfunction in schizophrenia therefore permits evaluation of underlying etiologic hypotheses. Objectives To evaluate magnocellular dysfunction in schizophrenia, relative to known neurochemical and neuroanatomical substrates, and to examine relationships between electrophysiological and behavioral measures of visual pathway dysfunction and relationships with higher cognitive deficits. Design, Setting, and Participants Between-group study at an inpatient state psychiatric hospital and out-patient county psychiatric facilities. Thirty-three patients met DSM-IV criteria for schizophrenia or schizoaffective disorder, and 21 nonpsychiatric volunteers of similar ages composed the control group. Main Outcome Measures (1) Magnocellular and parvocellular evoked potentials, analyzed using nonlinear (Michaelis-Menten) and linear contrast gain approaches; (2) behavioral contrast sensitivity measures; (3) white matter integrity; (4) visual and nonvisual neuropsychological measures, and (5) clinical symptom and community functioning measures. Results Patients generated evoked potentials that were significantly reduced in response to magnocellular-biased, but not parvocellular-biased, stimuli (P=.001). Michaelis-Menten analyses demonstrated reduced contrast gain of the magnocellular system (P=.001). Patients showed decreased contrast sensitivity to magnocellular-biased stimuli (P<.001). Evoked potential deficits were significantly related to decreased white matter integrity in the optic radiations (P<.03). Evoked potential deficits predicted impaired contrast sensitivity (P=.002), which was in turn related to deficits in complex visual processing (P≤.04). Both evoked potential (P≤.04) and contrast sensitivity (P=.01) measures significantly predicted community functioning. Conclusions These findings confirm the existence of early-stage visual processing dysfunction in schizophrenia and provide the first evidence that such deficits are due to decreased nonlinear signal amplification, consistent with glutamatergic theories. Neuroimaging studies support the hypothesis of dysfunction within low-level visual pathways involving thalamocortical radiations. Deficits in early-stage visual processing significantly predict higher cognitive deficits. PMID:15867102

All Features Great and Small-the Potential Roles of the Baculum and Penile Spines in Mammals.

PubMed

Orr, Teri J; Brennan, Patricia L R

2016-10-01

Mammalian penises are morphologically diverse, including a highly variable and taxonomically informative baculum (os penis), and variable penile spines, both of which are possessed by many-but not all-species. To understand the evolution of genital morphologies, as well as the potential role of both the baculum, and penile spines that directly interact with female reproductive tract, we undertook a comparative study of male penile spines and their relationship with the baculum across all mammalian orders. Specifically, we investigated several factors that may explain the presence or absence of penile spines in mammals, including mating system, risk of sperm competition, female reproductive physiology, presence and width of the baculum, and phylogenetic history. We observed that the presence of both the baculum and penile spines is correlated with residual testes size, suggesting a potential role in sexual selection for these traits. We found no association between the presence of spines and mating system, or with the presence/width of the baculum, although relative testes mass was marginally associated with baculum width. We found no relationship between baculum presence or width and mating system. We also noted that spines presence or absence have an order-level distribution, and clear phylogenetic patterns of distribution across mammals. It is likely that spine morphology and distribution, not just presence, play an important role in genital evolution in mammals, but these features are poorly described in most groups. Quantitative data collection in most mammalian taxa would be useful to further elucidate the evolution of the complex genital morphology of this group. © The Author 2016. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Patient and provider perspectives on the potential value and use of a bilingual online patient portal in a Spanish-speaking safety-net population.

PubMed

Ochoa, Alejandro; Kitayama, Ken; Uijtdehaage, Sebastian; Vermillion, Michelle; Eaton, Michael; Carpio, Felix; Serota, Martin; Hochman, Michael E

2017-11-01

To assess patient and provider perspectives on the potential value and use of a bilingual patient portal in a large safety-net health system serving predominantly Spanish-speaking patients. We captured patient and provider perspectives through the administration of surveys to assess Internet access, barriers, and facilitators to patient portal adoption, along with portal preferences. We report on these survey results using descriptive and comparative statistics. Four hundred patients (82% response rate) and 59 providers (80% response rate) participated in the study. Although 73% of providers believed that the patient portal would increase patient satisfaction, just 39% planned to recommend portal use to patients, citing concerns related to time and reimbursement. In contrast, 72% of patients believed the patient portal would strengthen the patient-provider relationship and 77% believed it would improve the quality of care. Latino patients in particular believed the patient portal would strengthen the patient-provider relationship. Seventy-five percent of patients reported interest in a mobile version of the portal. Patients from a safety-net health system, most of whom were Spanish-speaking, reported a high level of interest in the patient portal. Providers at the same health system expressed reluctance about the portal due to concerns related to time and reimbursement. Bilingual patient portal implementation has considerable potential to promote health care engagement within Spanish-speaking safety-net populations; however, lack of provider engagement in the process could undermine the effort. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Crossing levels in systems ergonomics: a framework to support 'mesoergonomic' inquiry.

PubMed

Karsh, Ben-Tzion; Waterson, Patrick; Holden, Richard J

2014-01-01

In this paper we elaborate and articulate the need for what has been termed 'mesoergonomics'. In particular, we argue that the concept has the potential to bridge the gap between, and integrate, established work within the domains of micro- and macroergonomics. Mesoergonomics is defined as an open systems approach to human factors and ergonomics (HFE) theory and research whereby the relationship between variables in at least two different system levels or echelons is studied, and where the dependent variables are human factors and ergonomic constructs. We present a framework which can be used to structure a set of questions for future work and prompt further empirical and conceptual inquiry. The framework consists of four steps: (1) establishing the purpose of the mesoergonomic investigation; (2) selecting human factors and ergonomics variables; (3) selecting a specific type of mesoergonomic investigation; and (4) establishing relationships between system levels. In addition, we describe two case studies which illustrate the workings of the framework and the value of adopting a mesoergonomic perspective within HFE. The paper concludes with a set of issues which could form part of a future agenda for research within systems ergonomics. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Neural mechanisms tracking popularity in real-world social networks.

PubMed

Zerubavel, Noam; Bearman, Peter S; Weber, Jochen; Ochsner, Kevin N

2015-12-08

Differences in popularity are a key aspect of status in virtually all human groups and shape social interactions within them. Little is known, however, about how we track and neurally represent others' popularity. We addressed this question in two real-world social networks using sociometric methods to quantify popularity. Each group member (perceiver) viewed faces of every other group member (target) while whole-brain functional MRI data were collected. Independent functional localizer tasks were used to identify brain systems supporting affective valuation (ventromedial prefrontal cortex, ventral striatum, amygdala) and social cognition (dorsomedial prefrontal cortex, precuneus, temporoparietal junction), respectively. During the face-viewing task, activity in both types of neural systems tracked targets' sociometric popularity, even when controlling for potential confounds. The target popularity-social cognition system relationship was mediated by valuation system activity, suggesting that observing popular individuals elicits value signals that facilitate understanding their mental states. The target popularity-valuation system relationship was strongest for popular perceivers, suggesting enhanced sensitivity to differences among other group members' popularity. Popular group members also demonstrated greater interpersonal sensitivity by more accurately predicting how their own personalities were perceived by other individuals in the social network. These data offer insights into the mechanisms by which status guides social behavior.

Is sustainability achievable? Exploring the limits of sustainability with model systems.

PubMed

Shastri, Yogendra; Diwekar, Urmila; Cabezas, Heriberto; Williamson, James

2008-09-01

Successful implementation of sustainability ideas in ecosystem management requires a basic understanding of the often nonlinear and nonintuitive relationships among different dimensions of sustainability, particularly the system-wide implications of human actions. This basic understanding further includes a sense of the time scale of possible future events and the limits of what is and is not likely to be possible. With this understanding, systematic approaches can then be used to develop policy guidelines for the system. This article presents an illustration of these ideas by analyzing an integrated ecological-economic-social model, which comprises various ecological (natural) and domesticated compartments representing species along with a macroeconomic price setting model. The stable and qualitatively realistic model is used to analyze different relevant scenarios. Apart from highlighting complex relationships within the system, it identifies potentially unsustainable future developments such as increased human per capita consumption rates. Dynamic optimization is then used to develop time-dependent policy guidelines for the unsustainable scenarios using objective functions that aim to minimize fluctuations in the system's Fisher information. The results can help to identify effective policy parameters and highlight the tradeoff between natural and domesticated compartments while managing such integrated systems. The results should also qualitatively guide further investigations in the area of system level studies and policy development.

Possible relationship between endocrine disrupting chemicals and hormone dependent gynecologic cancers.

PubMed

Dogan, Selen; Simsek, Tayup

2016-07-01

The effects of the natural and synthetic estrogens have been studied for a long time but the data regarding estrogen related chemicals (endocrine disrupting chemicals, EDCs) and their effects on reproductive system are scarce. EDCs are hormone like agents that are readily present in the environment, which may alter the endocrine system of humans and animals. Approximately 800 chemicals are known or suspected to have the potential to function as EDC. Potential role of EDCs on reproductive disease has gained attention in medical literature in recent years. We hypothesize that exposure to low doses of EDCs in a chronic manner could cause hormone dependent genital cancers including ovarian and endometrial cancer. Long term exposure to low concentrations of EDCs may exert potentiation effect with each other and even with endogenous estrogens and could inhibit enzymes responsible for estrogen metabolism. Exposure time to these EDCs is essential as we have seen from Diethylstilbestrol experience. Dose-response curves of EDCs are also unpredictable. Hence mode of action of EDCs are more complex than previously thought. In the light of these controversies lower doses of EDCs in long term exposure is not harmless. Possibility of this relationship and this hypothesis merit further investigation especially through in vivo studies that could better show the realistic environmental exposure. With the confirmation of our hypothesis, possible EDCs could be identified and eliminated from general use as a public health measure. Copyright © 2016 Elsevier Ltd. All rights reserved.

Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers.

PubMed

Davis, M E; Pun, S H; Bellocq, N C; Reineke, T M; Popielarski, S R; Mishra, S; Heidel, J D

2004-01-01

Non-viral (synthetic) nucleic acid delivery systems have the potential to provide for the practical application of nucleic acid-based therapeutics. We have designed and prepared a tunable, non-viral nucleic acid delivery system that self-assembles with nucleic acids and centers around a new class of polymeric materials; namely, linear, water-soluble cyclodextrin-containing polymers. The relationships between polymer structure and gene delivery are illustrated, and the roles of the cyclodextrin moieties for minimizing toxicity and forming inclusion complexes in the self-assembly processes are highlighted. This vehicle is the first example of a polymer-based gene delivery system formed entirely by self-assembly.

The evolution of nervous system patterning: insights from sea urchin development

PubMed Central

Angerer, Lynne M.; Yaguchi, Shunsuke; Angerer, Robert C.; Burke, Robert D.

2011-01-01

Recent studies of the sea urchin embryo have elucidated the mechanisms that localize and pattern its nervous system. These studies have revealed the presence of two overlapping regions of neurogenic potential at the beginning of embryogenesis, each of which becomes progressively restricted by separate, yet linked, signals, including Wnt and subsequently Nodal and BMP. These signals act to specify and localize the embryonic neural fields – the anterior neuroectoderm and the more posterior ciliary band neuroectoderm – during development. Here, we review these conserved nervous system patterning signals and consider how the relationships between them might have changed during deuterostome evolution. PMID:21828090

Genomics of Escherichia and Shigella

NASA Astrophysics Data System (ADS)

Perna, Nicole T.

The laboratory workhorse Escherichia coli K-12 is among the most intensively studied living organisms on earth, and this single strain serves as the model system behind much of our understanding of prokaryotic molecular biology. Dense genome sequencing and recent insightful comparative analyses are making the species E. coli, as a whole, an emerging system for studying prokaryotic population genetics and the relationship between system-scale, or genome-scale, molecular evolution and complex traits like host range and pathogenic potential. Genomic perspective has revealed a coherent but dynamic species united by intraspecific gene flow via homologous lateral or horizontal transfer and differentiated by content flux mediated by acquisition of DNA segments from interspecies transfers.

Benefits and costs of alcoholic relationships and recovery through Al-Anon.

PubMed

Young, Lance Brendan; Timko, Christine

2015-01-01

Codependence is an ambiguous and disputed term often used to characterize both those who maintain relationships with alcoholics and those who seek help through resources such as Al-Anon Family Groups. The purpose of this article is to better understand non-pathological reasons for maintaining alcoholic relationships and for help-seeking by detailing the costs and benefits of those choices. The costs and benefits both of remaining in an alcoholic relationship and of seeking help in Al-Anon were identified through a review of available research on alcoholic family systems, Al-Anon, and other mutual-support groups. Alcoholic relationships may benefit concerned others by preserving self-identity, social identity, values, security, stability, and hope. Costs of alcoholic relationships include physical symptoms, injury, mental problems, financial difficulty, legal troubles, and relational distress. Al-Anon is perceived beneficial for six primary reasons: Al-Anon philosophy, format, social support, accessibility, effectiveness, and potential to change the drinker's behavior. Possible costs of Al-Anon include marginalization of the concerned other, blame, codependent pathology, sexist stereotyping, substitute dependency, and perpetuating victimization. Conclusions/Importance: The identified costs and benefits of alcoholic relationships and help-seeking in Al-Anon can help to model decision-making processes using existing behavioral health frameworks without defaulting to the stigmatized and ambiguous codependence terminology.

Value-centric design architecture based on analysis of space system characteristics

NASA Astrophysics Data System (ADS)

Xu, Q.; Hollingsworth, P.; Smith, K.

2018-03-01

Emerging design concepts such as miniaturisation, modularity, and standardisation, have contributed to the rapid development of small and inexpensive platforms, particularly cubesats. This has been stimulating an upcoming revolution in space design and development, leading satellites into the era of "smaller, faster, and cheaper". However, the current requirement-centric design philosophy, focused on bespoke monolithic systems, along with the associated development and production process does not inherently fit with the innovative modular, standardised, and mass-produced technologies. This paper presents a new categorisation, characterisation, and value-centric design architecture to address this need for both traditional and novel system designs. Based on the categorisation of system configurations, a characterisation of space systems, comprised of duplication, fractionation, and derivation, is proposed to capture the overall system configuration characteristics and promote potential hybrid designs. Complying with the definitions of the system characterisation, mathematical mapping relations between the system characterisation and the system properties are described to establish the mathematical foundation of the proposed value-centric design methodology. To illustrate the methodology, subsystem reliability relationships are therefore analysed to explore potential system configurations in the design space. The results of the applications of system characteristic analysis clearly show that the effects of different configuration characteristics on the system properties can be effectively analysed and evaluated, enabling the optimization of system configurations.

Building a system-wide approach to community relationships with the findings of a scoping review in health and social care.

PubMed

Grimshaw, Paul; McGowan, Linda; McNichol, Elaine

2016-10-10

Purpose For leadership and management of Western health systems, good quality relationships are a fundamental cornerstone of organising health and social care (H&SC) delivery, delivering benefits across organisations and communities. The purpose of this paper is to explore the extant management, H&SC literature, grounded in older people care, reveal behaviours, processes and practices that if readily identified across a context will support healthy relationships across the "whole system" of stakeholders. Design/methodology/approach An academic/practitioner group designed and guided a scoping literature review of the H&SC and broader management literature to identify and extract important behaviours, processes and practices underlying the support of high-quality relationships. A search strategy was agreed and key health and management databases were interrogated and 51 papers selected for inclusion. Working with the practitioners, the selected papers were coded and then organised into emergent themes. Findings The paper outlines the relational behaviours, processes and practice elements that should be present within an older peoples care community, to support a healthy relational environment. These elements are presented under the five emergent literature themes of integrity, compassion, respect, fairness and trust. These five topics are examined in detail. A way forward for building statements using the review material, that may be applied to reveal relational patterns within older people care, is also explored and outlined. Research limitations/implications All literature reviews are subject to practical decisions around time, budget, scope and depth restraints. Therefore potentially relevant papers may have been missed in the review process. The scoping review process adapted here does not seek to make any major considerations with regards to the weighting of evidence behind the primary research. Originality/value This paper contributes to a growing need for designers of health systems to more fully understand, measure and draw on the value of relationships to help bridge the gap between diminishing resources and the expanding demand on H&SC services.

Applying AN Object-Oriented Database Model to a Scientific Database Problem: Managing Experimental Data at Cebaf.

NASA Astrophysics Data System (ADS)

Ehlmann, Bryon K.

Current scientific experiments are often characterized by massive amounts of very complex data and the need for complex data analysis software. Object-oriented database (OODB) systems have the potential of improving the description of the structure and semantics of this data and of integrating the analysis software with the data. This dissertation results from research to enhance OODB functionality and methodology to support scientific databases (SDBs) and, more specifically, to support a nuclear physics experiments database for the Continuous Electron Beam Accelerator Facility (CEBAF). This research to date has identified a number of problems related to the practical application of OODB technology to the conceptual design of the CEBAF experiments database and other SDBs: the lack of a generally accepted OODB design methodology, the lack of a standard OODB model, the lack of a clear conceptual level in existing OODB models, and the limited support in existing OODB systems for many common object relationships inherent in SDBs. To address these problems, the dissertation describes an Object-Relationship Diagram (ORD) and an Object-oriented Database Definition Language (ODDL) that provide tools that allow SDB design and development to proceed systematically and independently of existing OODB systems. These tools define multi-level, conceptual data models for SDB design, which incorporate a simple notation for describing common types of relationships that occur in SDBs. ODDL allows these relationships and other desirable SDB capabilities to be supported by an extended OODB system. A conceptual model of the CEBAF experiments database is presented in terms of ORDs and the ODDL to demonstrate their functionality and use and provide a foundation for future development of experimental nuclear physics software using an OODB approach.

Jump Shrug Height and Landing Forces Across Various Loads.

PubMed

Suchomel, Timothy J; Taber, Christopher B; Wright, Glenn A

2016-01-01

The purpose of this study was to examine the effect that load has on the mechanics of the jump shrug. Fifteen track and field and club/intramural athletes (age 21.7 ± 1.3 y, height 180.9 ± 6.6 cm, body mass 84.7 ± 13.2 kg, 1-repetition-maximum (1RM) hang power clean 109.1 ± 17.2 kg) performed repetitions of the jump shrug at 30%, 45%, 65%, and 80% of their 1RM hang power clean. Jump height, peak landing force, and potential energy of the system at jump-shrug apex were compared between loads using a series of 1-way repeated-measures ANOVAs. Statistical differences in jump height (P < .001), peak landing force (P = .012), and potential energy of the system (P < .001) existed; however, there were no statistically significant pairwise comparisons in peak landing force between loads (P > .05). The greatest magnitudes of jump height, peak landing force, and potential energy of the system at the apex of the jump shrug occurred at 30% 1RM hang power clean and decreased as the external load increased from 45% to 80% 1RM hang power clean. Relationships between peak landing force and potential energy of the system at jump-shrug apex indicate that the landing forces produced during the jump shrug may be due to the landing strategy used by the athletes, especially at lighter loads. Practitioners may prescribe heavier loads during the jump-shrug exercise without viewing landing force as a potential limitation.

Is There a Relationship between Fish Cannibalism and Latitude or Species Richness?

PubMed

Pereira, Larissa Strictar; Keppeler, Friedrich Wolfgang; Agostinho, Angelo Antonio; Winemiller, Kirk O

2017-01-01

Cannibalism has been commonly observed in fish from northern and alpine regions and less frequently reported for subtropical and tropical fish in more diverse communities. Assuming all else being equal, cannibalism should be more common in communities with lower species richness because the probability of encountering conspecific versus heterospecific prey would be higher. A global dataset was compiled to determine if cannibalism occurrence is associated with species richness and latitude. Cannibalism occurrence, local species richness and latitude were recorded for 4,100 populations of 2,314 teleost fish species. Relationships between cannibalism, species richness and latitude were evaluated using generalized linear mixed models. Species richness was an important predictor of cannibalism, with occurrences more frequently reported for assemblages containing fewer species. Cannibalism was positively related with latitude for both marine and freshwater ecosystems in the Northern Hemisphere, but not in the Southern Hemisphere. The regression slope for the relationship was steeper for freshwater than marine fishes. In general, cannibalism is more frequent in communities with lower species richness, and the relationship between cannibalism and latitude is stronger in the Northern Hemisphere. In the Southern Hemisphere, weaker latitudinal gradients of fish species richness may account for the weak relationship between cannibalism and latitude. Cannibalism may be more common in freshwater than marine systems because freshwater habitats tend to be smaller and more closed to dispersal. Cannibalism should have greatest potential to influence fish population dynamics in freshwater systems at high northern latitudes.

Is There a Relationship between Fish Cannibalism and Latitude or Species Richness?

PubMed Central

Keppeler, Friedrich Wolfgang; Agostinho, Angelo Antonio; Winemiller, Kirk O.

2017-01-01

Cannibalism has been commonly observed in fish from northern and alpine regions and less frequently reported for subtropical and tropical fish in more diverse communities. Assuming all else being equal, cannibalism should be more common in communities with lower species richness because the probability of encountering conspecific versus heterospecific prey would be higher. A global dataset was compiled to determine if cannibalism occurrence is associated with species richness and latitude. Cannibalism occurrence, local species richness and latitude were recorded for 4,100 populations of 2,314 teleost fish species. Relationships between cannibalism, species richness and latitude were evaluated using generalized linear mixed models. Species richness was an important predictor of cannibalism, with occurrences more frequently reported for assemblages containing fewer species. Cannibalism was positively related with latitude for both marine and freshwater ecosystems in the Northern Hemisphere, but not in the Southern Hemisphere. The regression slope for the relationship was steeper for freshwater than marine fishes. In general, cannibalism is more frequent in communities with lower species richness, and the relationship between cannibalism and latitude is stronger in the Northern Hemisphere. In the Southern Hemisphere, weaker latitudinal gradients of fish species richness may account for the weak relationship between cannibalism and latitude. Cannibalism may be more common in freshwater than marine systems because freshwater habitats tend to be smaller and more closed to dispersal. Cannibalism should have greatest potential to influence fish population dynamics in freshwater systems at high northern latitudes. PMID:28122040

Insights from event-related potentials into the temporal and hierarchical organization of the ventral and dorsal streams of the visual system in selective attention.

PubMed

Martín-Loeches, M; Hinojosa, J A; Rubia, F J

1999-11-01

The temporal and hierarchical relationships between the dorsal and the ventral streams in selective attention are known only in relation to the use of spatial location as the attentional cue mediated by the dorsal stream. To improve this state of affairs, event-related brain potentials were recorded while subjects attended simultaneously to motion direction (mediated by the dorsal stream) and to a property mediated by the ventral stream (color or shape). At about the same time, a selection positivity (SP) started for attention mediated by both streams. However, the SP for color and shape peaked about 60 ms later than motion SP. Subsequently, a selection negativity (SN) followed by a late positive component (LPC) were found simultaneously for attention mediated by both streams. A hierarchical relationship between the two streams was not observed, but neither SN nor LPC for one property was completely insensitive to the values of the other property.

Identification of Genetic Bases of Vibrio fluvialis Species-Specific Biochemical Pathways and Potential Virulence Factors by Comparative Genomic Analysis

PubMed Central

Lu, Xin; Liang, Weili; Wang, Yunduan; Xu, Jialiang

2014-01-01

Vibrio fluvialis is an important food-borne pathogen that causes diarrheal illness and sometimes extraintestinal infections in humans. In this study, we sequenced the genome of a clinical V. fluvialis strain and determined its phylogenetic relationships with other Vibrio species by comparative genomic analysis. We found that the closest relationship was between V. fluvialis and V. furnissii, followed by those with V. cholerae and V. mimicus. Moreover, based on genome comparisons and gene complementation experiments, we revealed genetic mechanisms of the biochemical tests that differentiate V. fluvialis from closely related species. Importantly, we identified a variety of genes encoding potential virulence factors, including multiple hemolysins, transcriptional regulators, and environmental survival and adaptation apparatuses, and the type VI secretion system, which is indicative of complex regulatory pathways modulating pathogenesis in this organism. The availability of V. fluvialis genome sequences may promote our understanding of pathogenic mechanisms for this emerging pathogen. PMID:24441165

Implications of Electronic Commerce for Fiscal Policy

NASA Astrophysics Data System (ADS)

Goolsbee, Austan

In this chapter, I will consider both sides of the relationship between electronic commerce and fiscal policy. For the impact of electronic commerce on fiscal policy, I will pay particular attention to the potential sales-tax revenue losses. The data suggest that the potential losses are actually modest over the next several years. I will also consider the reverse relationship - how fiscal policy affects Internet commerce. Here the evidence suggests that taxes have a sizable effect. I point out, though, that this only supports special treatment if there is some positive externality. Without one, the tax system will lead to excessive online buying to avoid taxes. I will then deal the neglected issue of taxes and Internet access, which can create large deadweight costs both because demand may be price-sensitive and because taxes can slow the spread of new technologies. Finally, I offer some discussion of the international context of taxes and the Internet and the international temptations to raise rates on E-commerce.

How Do Alcohol and Relationship Type Affect Women’s Risk Judgment of Partners with Differing Risk Histories?

PubMed Central

Norris, Jeanette; Kiekel, Preston A.; Morrison, Diane M.; Davis, Kelly Cue; George, William H.; Zawacki, Tina; Abdallah, Devon Alisa; Jacques-Tiura, Angela J.; Stappenbeck, Cynthia A.

2013-01-01

Understanding how women judge male partners’ sexual risk is important to developing risk reduction programs. Applying a cognitive mediation model of sexual decision making, our study investigated effects of alcohol consumption (control, low dose, high dose) and relationship type (disrupted vs. new) on women’s risk judgments of a male sexual partner in three sexual risk conditions (low, unknown, high). After random assignment to an experimental condition, 328 participants projected themselves into a story depicting a sexual interaction. The story was paused to assess primary appraisals of sexual and relationship potential and secondary appraisals of pleasure, health, and relationship concerns, followed by sexual risk judgments. In all risk conditions, alcohol and disrupted relationship increased sexual potential whereas disrupted relationship increased relationship potential in the low- and high-risk conditions. In the unknown-risk condition, women in the no-alcohol, new relationship condition had the lowest primary sexual appraisals. In all conditions, sexual appraisals predicted all secondary appraisals, but primary relationship appraisals predicted only secondary relationship appraisals. Secondary health appraisals led to increased risk judgments whereas relationship appraisals predicted lower risk judgments. Possible intervention points include helping women to re-evaluate their safety beliefs about past partners, as well as to develop behavioral strategies for decreasing hazardous drinking. PMID:24003264

Comparative Genomic Analysis Reveals a Diverse Repertoire of Genes Involved in Prokaryote-Eukaryote Interactions within the Pseudovibrio Genus

PubMed Central

Romano, Stefano; Fernàndez-Guerra, Antonio; Reen, F. Jerry; Glöckner, Frank O.; Crowley, Susan P.; O'Sullivan, Orla; Cotter, Paul D.; Adams, Claire; Dobson, Alan D. W.; O'Gara, Fergal

2016-01-01

Strains of the Pseudovibrio genus have been detected worldwide, mainly as part of bacterial communities associated with marine invertebrates, particularly sponges. This recurrent association has been considered as an indication of a symbiotic relationship between these microbes and their host. Until recently, the availability of only two genomes, belonging to closely related strains, has limited the knowledge on the genomic and physiological features of the genus to a single phylogenetic lineage. Here we present 10 newly sequenced genomes of Pseudovibrio strains isolated from marine sponges from the west coast of Ireland, and including the other two publicly available genomes we performed an extensive comparative genomic analysis. Homogeneity was apparent in terms of both the orthologous genes and the metabolic features shared amongst the 12 strains. At the genomic level, a key physiological difference observed amongst the isolates was the presence only in strain P. axinellae AD2 of genes encoding proteins involved in assimilatory nitrate reduction, which was then proved experimentally. We then focused on studying those systems known to be involved in the interactions with eukaryotic and prokaryotic cells. This analysis revealed that the genus harbors a large diversity of toxin-like proteins, secretion systems and their potential effectors. Their distribution in the genus was not always consistent with the phylogenetic relationship of the strains. Finally, our analyses identified new genomic islands encoding potential toxin-immunity systems, previously unknown in the genus. Our analyses shed new light on the Pseudovibrio genus, indicating a large diversity of both metabolic features and systems for interacting with the host. The diversity in both distribution and abundance of these systems amongst the strains underlines how metabolically and phylogenetically similar bacteria may use different strategies to interact with the host and find a niche within its microbiota. Our data suggest the presence of a sponge-specific lineage of Pseudovibrio. The reduction in genome size and the loss of some systems potentially used to successfully enter the host, leads to the hypothesis that P. axinellae strain AD2 may be a lineage that presents an ancient association with the host and that may be vertically transmitted to the progeny. PMID:27065959

Projecting climate-driven increases in North American fire activity

NASA Astrophysics Data System (ADS)

Wang, D.; Morton, D. C.; Collatz, G. J.

2013-12-01

Climate regulates fire activity through controls on vegetation productivity (fuels), lightning ignitions, and conditions governing fire spread. In many regions of the world, human management also influences the timing, duration, and extent of fire activity. These coupled interactions between human and natural systems make fire a complex component of the Earth system. Satellite data provide valuable information on the spatial and temporal dynamics of recent fire activity, as active fires, burned area, and land cover information can be combined to separate wildfires from intentional burning for agriculture and forestry. Here, we combined satellite-derived burned area data with land cover and climate data to assess fire-climate relationships in North America between 2000-2012. We used the latest versions of the Global Fire Emissions Database (GFED) burned area product and Modern-Era Retrospective Analysis for Research and Applications (MERRA) climate data to develop regional relationships between burned area and potential evaporation (PE), an integrated dryness metric. Logistic regression models were developed to link burned area with PE and individual climate variables during and preceding the fire season, and optimal models were selected based on Akaike Information Criterion (AIC). Overall, our model explained 85% of the variance in burned area since 2000 across North America. Fire-climate relationships from the era of satellite observations provide a blueprint for potential changes in fire activity under scenarios of climate change. We used that blueprint to evaluate potential changes in fire activity over the next 50 years based on twenty models from the Coupled Model Intercomparison Project Phase 5 (CMIP5). All models suggest an increase of PE under low and high emissions scenarios (Representative Concentration Pathways (RCP) 4.5 and 8.5, respectively), with largest increases in projected burned area across the western US and central Canada. Overall, near-term climate projections point to pronounced changes in fire season length, total burned area, and the frequency of extreme events across North America by 2050.

Relation between functional magnetic resonance imaging (fMRI) and single neuron, local field potential (LFP) and electrocorticography (ECoG) activity in human cortex.

PubMed

Ojemann, George A; Ojemann, Jeffrey; Ramsey, Nick F

2013-01-01

The relation between changes in the blood oxygen dependent metabolic changes imaged by functional magnetic resonance imaging (fMRI) and neural events directly recorded from human cortex from single neurons, local field potentials (LFPs) and electrocorticogram (ECoG) is critically reviewed, based on the published literature including findings from the authors' laboratories. All these data are from special populations, usually patients with medically refractory epilepsy, as this provides the major opportunity for direct cortical neuronal recording in humans. For LFP and ECoG changes are often sought in different frequency bands, for single neurons in frequency of action potentials. Most fMRI studies address issues of functional localization. The relation of those findings to localized changes in neuronal recordings in humans has been established in several ways. Only a few studies have directly compared changes in activity from the same sites in the same individual, using the same behavioral measure. More often the comparison has been between fMRI and electrophysiologic changes in populations recorded from the same functional anatomic system as defined by lesion effects; in a few studies those systems have been defined by fMRI changes such as the "default" network. The fMRI-electrophysiologic relationships have been evaluated empirically by colocalization of significant changes, and by quantitative analyses, often multiple linear regression. There is some evidence that the fMRI-electrophysiology relationships differ in different cortical areas, particularly primary motor and sensory cortices compared to association cortex, but also within areas of association cortex. Although crucial for interpretation of fMRI changes as reflecting neural activity in human cortex, controversy remains as to these relationships. Supported by: Dutch Technology Foundation and University of Utrecht Grant UGT7685, ERC-Advanced grant 320708 (NR) and NIH grant NS065186 (JO).

Trade-offs between high yields and greenhouse gas emissions in irrigation wheat cropland in China

NASA Astrophysics Data System (ADS)

Cui, Z. L.; Wu, L.; Ye, Y. L.; Ma, W. Q.; Chen, X. P.; Zhang, F. S.

2014-04-01

Although the concept of producing higher yields with reduced greenhouse gas (GHG) emissions is a goal that attracts increasing public and scientific attention, the trade-off between high yields and GHG emissions in intensive agricultural production is not well understood. Here, we hypothesize that there exists a mechanistic relationship between wheat grain yield and GHG emission, and that could be transformed into better agronomic management. A total 33 sites of on-farm experiments were investigated to evaluate the relationship between grain yield and GHG emissions using two systems (conventional practice, CP; high-yielding systems, HY) of intensive winter wheat (Triticum aestivum L.) in China. Furthermore, we discussed the potential to produce higher yields with lower GHG emissions based on a survey of 2938 farmers. Compared to the CP system, grain yield was 39% (2352 kg ha-1) higher in the HY system, while GHG emissions increased by only 10%, and GHG emission intensity was reduced by 21%. The current intensive winter wheat system with farmers' practice had a median yield and maximum GHG emission rate of 6050 kg ha-1 and 4783 kg CO2 eq ha-1, respectively; however, this system can be transformed to maintain yields while reducing GHG emissions by 26% (6077 kg ha-1, and 3555 kg CO2 eq ha-1). Further, the HY system was found to increase grain yield by 39% with a simultaneous reduction in GHG emissions by 18% (8429 kg ha-1, and 3905 kg CO2 eq ha-1, respectively). In the future, we suggest moving the trade-off relationships and calculations from grain yield and GHG emissions to new measures of productivity and environmental protection using innovative management technologies.

Relation of Different Type Love-Shida Numbers Determined with the Use of Time-Varying Incremental Gravitational Potential

NASA Astrophysics Data System (ADS)

Varga, Peter; Grafarend, Erik; Engels, Johannes

2017-03-01

There are different equations to describe relations between different classes of Love-Shida numbers. In this study with the use of the time-varying gravitational potential an integral relation was obtained which connects tidal Love-Shida numbers (h, l, k), load numbers (h', l', k'), potential free Love-Shida numbers generated by normal (h″, l″, k″) and horizontal (h‴, l‴, k‴) stresses. The equations obtained in frame of present study is the only one which - holds for every type of Love-Shida numbers, - describes a relationship not between different, but the same type of Love-Shida numbers, - does not follow from the sixth-order differential equation system of motion usually applied to calculate the Love-Shida numbers.

Assessment of drinking water quality at the tap using fluorescence spectroscopy.

PubMed

Heibati, Masoumeh; Stedmon, Colin A; Stenroth, Karolina; Rauch, Sebastien; Toljander, Jonas; Säve-Söderbergh, Melle; Murphy, Kathleen R

2017-11-15

Treated drinking water may become contaminated while travelling in the distribution system on the way to consumers. Elevated dissolved organic matter (DOM) at the tap relative to the water leaving the treatment plant is a potential indicator of contamination, and can be measured sensitively, inexpensively and potentially on-line via fluorescence and absorbance spectroscopy. Detecting elevated DOM requires potential contamination events to be distinguished from natural fluctuations in the system, but how much natural variation to expect in a stable distribution system is unknown. In this study, relationships between DOM optical properties, microbial indicator organisms and trace elements were investigated for households connected to a biologically-stable drinking water distribution system. Across the network, humic-like fluorescence intensities showed limited variation (RSD = 3.5-4.4%), with half of measured variation explained by interactions with copper. After accounting for quenching by copper, fluorescence provided a very stable background signal (RSD < 2.2%) against which a ∼2% infiltration of soil water would be detectable. Smaller infiltrations would be detectable in the case of contamination by sewage with a strong tryptophan-like fluorescence signal. These findings indicate that DOM fluorescence is a sensitive indicator of water quality changes in drinking water networks, as long as potential interferents are taken into account. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Quantum Mechanics, Pattern Recognition, and the Mammalian Brain

NASA Astrophysics Data System (ADS)

Chapline, George

2008-10-01

Although the usual way of representing Markov processes is time asymmetric, there is a way of describing Markov processes, due to Schrodinger, which is time symmetric. This observation provides a link between quantum mechanics and the layered Bayesian networks that are often used in automated pattern recognition systems. In particular, there is a striking formal similarity between quantum mechanics and a particular type of Bayesian network, the Helmholtz machine, which provides a plausible model for how the mammalian brain recognizes important environmental situations. One interesting aspect of this relationship is that the "wake-sleep" algorithm for training a Helmholtz machine is very similar to the problem of finding the potential for the multi-channel Schrodinger equation. As a practical application of this insight it may be possible to use inverse scattering techniques to study the relationship between human brain wave patterns, pattern recognition, and learning. We also comment on whether there is a relationship between quantum measurements and consciousness.

Patient satisfaction scores and their relationship to hospital website quality measures.

PubMed

Ford, Eric W; Huerta, Timothy R; Diana, Mark L; Kazley, Abby Swanson; Menachemi, Nir

2013-01-01

Hospitals and health systems are using web-based and social media tools to market themselves to consumers with increasingly sophisticated strategies. These efforts are designed to shape the consumers' expectations, influence their purchase decisions, and build a positive reputation in the marketplace. Little is known about how these web-based marketing efforts are taking form and if they have any relationship to consumers' satisfaction with the services they receive. The purpose of this study is to assess if a relationship exists between the quality of hospitals' public websites and their aggregated patient satisfaction ratings. Based on analyses of 1,952 U.S. hospitals, our results show that website quality is significantly and positively related to patients' overall rating of the hospital and their intention to recommend the facility to others. The potential for web-based information sources to influence consumer behavior has important implications for policymakers, third-party payers, health care providers, and consumers.

Models for preclinical studies in aging-related disorders: One is not for all

PubMed Central

Santulli, Gaetano; Borras, Consuelo; Bousquet, Jean; Calzà, Laura; Cano, Antonio; Illario, Maddalena; Franceschi, Claudio; Liotta, Giuseppe; Maggio, Marcello; Molloy, William D.; Montuori, Nunzia; O’Caoimh, Rónán; Orfila, Francesc; Rauter, Amelia P.; Santoro, Aurelia; Iaccarino, Guido

2015-01-01

Preclinical studies are essentially based on animal models of a particular disease. The primary purpose of preclinical efficacy studies is to support generalization of treatment–effect relationships to human subjects. Researchers aim to demonstrate a causal relationship between an investigational agent and a disease-related phenotype in such models. Numerous factors can muddle reliable inferences about such cause-effect relationships, including biased outcome assessment due to experimenter expectations. For instance, responses in a particular inbred mouse might be specific to the strain, limiting generalizability. Selecting well-justified and widely acknowledged model systems represents the best start in designing preclinical studies, especially to overcome any potential bias related to the model itself. This is particularly true in the research that focuses on aging, which carries unique challenges, mainly attributable to the fact that our already long lifespan makes designing experiments that use people as subjects extremely difficult and largely impractical. PMID:27042427

Examining the Relationships Between Education, Social Networks and Democratic Support With ABM

NASA Technical Reports Server (NTRS)

Drucker, Nick; Campbell, Kenyth

2011-01-01

This paper introduces an agent-based model that explores the relationships between education, social networks, and support for democratic ideals. This study examines two factors thai affect democratic support, education, and social networks. Current theory concerning these two variables suggests that positive relationships exist between education and democratic support and between social networks and the spread of ideas. The model contains multiple variables of democratic support, two of which are evaluated through experimentation. The model allows individual entities within the system to make "decisions" about their democratic support independent of one another. The agent based approach also allows entities to utilize their social networks to spread ideas. Current theory supports experimentation results. In addion , these results show the model is capable of reproducing real world outcomes. This paper addresses the model creation process and the experimentation procedure, as well as future research avenues and potential shortcomings of the model

Work-Load Planning for Navy Stock Points

DTIC Science & Technology

1990-12-01

capacity. 2. The level of utilization of a non -bottleneck is not determined by its own potential, but by some other constraint in the system. 3...the amounts to carry based on customer demands and non -demand based requirements II. Basic Operations A. Determines which items to carry in inventory...storage, physical inventory, issue, transportation, and 8 control of material. The focus was to be primarily on the relationships among functions in

Cyclical Dynamics and Control of a Neuromechanical System

DTIC Science & Technology

2012-01-01

of the membrane potentials and synaptic conductances of neurons in the CPG model, or the lengths, velocities, and calcium concentrations in a muscle...empirical data. • We found that muscle is strongly self-stabilizing when activated cyclically, possibly because of the nonlinearity in how calcium binds and...only its natural calcium dynamics and length, velocity, and tension relationships, is strongly self-stabilizing. I plan to submit these results as an

Mastocytosis of the female breast.

PubMed

Setia, Namrata; Crisi, Giovanna M; Pantanowitz, Liron

2010-10-01

A subset of patients with systemic mastocytosis may manifest with extracutaneous involvement. To the best of our knowledge, mastocytosis of the human breast has not been described. This study reports a case with mastocytosis involving the breasts of a 33-year-old woman associated with mammary hypertrophy (breast mastocytosis). The potential for infiltrating mast cells to mimic lobular carcinoma is emphasized and the relationship to breast hypertrophy in this case is discussed.

The Relationship of the Officer Evaluation Report to Captain Attrition

DTIC Science & Technology

2001-05-31

especially, Microsoft licensing. The OER plays a significant role in each of these stages, determining or predicting an officer’s potential for career success . The...company command greatly raises expectations for continued career success . Those that have a positive command experience with at least one above center of...system, especially pertaining to branch qualification was reviewed. Nearly 85% had been advised by their branch assignment officer, that future career

Sources of perceived responsiveness in family relationships.

PubMed

Cook, William L; Dezangré, Marie; De Mol, Jan

2018-05-10

Perceived responsiveness has become one of the most important constructs in the relationship sciences. It is central to the development of a secure attachment style, the experience of social support, an internal locus of control, and the sense of control in close relationships. Conversely, an unresponsive environment is associated with learned helplessness and depression. Viewed through the lens of the social relations model (SRM), perceived responsiveness in family relationships could have multiple sources: the perceiver; the target or partner; the perceiver-target relationship; and the family group. This study used the SRM to determine the relative importance of these sources of perceived responsiveness in the relationships of 207 two-parent two-child families. Characteristics of the perceiver and the target each accounted for about 25% of the systematic variance in perceived responsiveness, whereas the perceiver-target relationship accounted for approximately 48%. At the individual level of analysis, reciprocity of perceived responsiveness was pervasive in the family relationships of the two children. Regardless of age, young people who generally perceived others as responsive were generally perceived by others as responsive. At the dyadic level of analysis, reciprocity was present in two dyads: mother-father and older child-younger child. Reliable target variances support the view that perceived responsiveness is not just "inside the head" of the perceiver, and reciprocity correlations suggest potentially useful systemic interventions. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Interacting lattice systems with quantum dissipation: A quantum Monte Carlo study

NASA Astrophysics Data System (ADS)

Yan, Zheng; Pollet, Lode; Lou, Jie; Wang, Xiaoqun; Chen, Yan; Cai, Zi

2018-01-01

Quantum dissipation arises when a large system can be split in a quantum system and an environment to which the energy of the former flows. Understanding the effect of dissipation on quantum many-body systems is of particular importance due to its potential relationship with quantum information. We propose a conceptually simple approach to introduce dissipation into interacting quantum systems in a thermodynamical context, in which every site of a one-dimensional (1D) lattice is coupled off-diagonally to its own bath. The interplay between quantum dissipation and interactions gives rise to counterintuitive interpretations such as a compressible zero-temperature state with spontaneous discrete symmetry breaking and a thermal phase transition in a 1D dissipative quantum many-body system as revealed by quantum Monte Carlo path-integral simulations.

Potential for local and systemic bacterial infection in some occupational groups in Benin City, Nigeria.

PubMed

Hugbo, P G; Okonkwo, J O

1992-06-01

Many Third World countries may not have adequate facilities for rapid sensitivity testing of antibiotics as an aid to diagnosis and chemotherapy. It may therefore be valuable to relate bacterial carriage on the skin to type of work a person does. Given areas of skin in workers from 10 occupational groups were sampled. The bacteria obtained were analyzed after growth on appropriate media. The sensitivity profiles of potential pathogens isolated from these groups, as well as of those (Staphylococcus aureus only) isolated from patients with certified infections, were carried out and the results were analyzed. Staphylococcus aureus constituted the most widely and frequently isolated potential pathogen. Proteus mirabilis, Escherichia coli, and Klebsiella species were also frequent colonizers of skin. There was a statistical relationship between work type and overall prevalence of bacteria on skin (p less than 0.01). Most isolates of the work groups were highly sensitive to gentamicin and cefuroxine but not to penicillin G, ampicillin, and trimethoprim plus sulfamethoxazole; isolates from infected persons were generally more resistant than were the community-acquired ones. A relationship may exist between the types of bacteria carried on the skin and the type of work in which a person is engaged.

Memory recall in arousing situations – an emotional von Restorff effect?

PubMed Central

Wiswede, Daniel; Rüsseler, Jascha; Hasselbach, Simone; Münte, Thomas F

2006-01-01

Background Previous research has demonstrated a relationship between memory recall and P300 amplitude in list learning tasks, but the variables mediating this P300-recall relationship are not well understood. In the present study, subjects were required to recall items from lists consisting of 12 words, which were presented in front of pictures taken from the IAPS collection. One word per list is made distinct either by font color or by a highly arousing background IAPS picture. This isolation procedure was first used by von Restorff. Brain potentials were recorded during list presentation. Results Recall performance was enhanced for color but not for emotional isolates. Event-related brain potentials (ERP) showed a more positive P300-component for recalled non-isolated words and color-isolated words, compared to the respective non-remembered words, but not for words isolated by arousing background. Conclusion Our findings indicate that it is crucial to take emotional mediator variables into account, when using the P300 to predict later recall. Highly arousing environments might force the cognitive system to interrupt rehearsal processes in working memory, which might benefit transfer into other, more stable memory systems. The impact of attention-capturing properties of arousing background stimuli is also discussed. PMID:16863589

Primary central nervous system lymphoma in immunocompetent individuals: a single center experience.

PubMed

Aki, Hilal; Uzunaslan, Didem; Saygin, Caner; Batur, Sebnem; Tuzuner, Nukhet; Kafadar, Ali; Ongoren, Seniz; Oz, Buge

2013-01-01

Primary central nervous system lymphoma (PCNSL) is defined as the involvement of brain, leptomeninges, eyes or spinal cord by non-Hodgkin lymphoma. The role of various prognostic markers in predicting adverse outcome is debated. To investigate the clinical and immunohistochemical findings of immunocompetent PCNSL cases (39 cases) diagnosed at the study center, and evaluate the influence of potential prognostic factors on overall survival (OS) of patients. Data regarding patient characteristics, neuroimaging, pathological and immunohistochemical features and follow-up were obtained from patient records. The influence of potential prognostic parameters on OS was investigated by log-rank test and Cox regression analysis. Patients who received combined chemotherapy and radiotherapy had a significantly better OS when compared to chemotherapy alone. Other variables included in this study were not associated with a significant survival advantage. In this study, we failed to demonstrate a relationship between different clinicopathological variables and OS of patients. Prospective studies with large patient series are needed to investigate other potential prognostic factors.

Simulating sunflower canopy temperatures to infer root-zone soil water potential

NASA Technical Reports Server (NTRS)

Choudhury, B. J.; Idso, S. B.

1983-01-01

A soil-plant-atmosphere model for sunflower (Helianthus annuus L.), together with clear sky weather data for several days, is used to study the relationship between canopy temperature and root-zone soil water potential. Considering the empirical dependence of stomatal resistance on insolation, air temperature and leaf water potential, a continuity equation for water flux in the soil-plant-atmosphere system is solved for the leaf water potential. The transpirational flux is calculated using Monteith's combination equation, while the canopy temperature is calculated from the energy balance equation. The simulation shows that, at high soil water potentials, canopy temperature is determined primarily by air and dew point temperatures. These results agree with an empirically derived linear regression equation relating canopy-air temperature differential to air vapor pressure deficit. The model predictions of leaf water potential are also in agreement with observations, indicating that measurements of canopy temperature together with a knowledge of air and dew point temperatures can provide a reliable estimate of the root-zone soil water potential.

Impact of delayed information in sub-second complex systems

NASA Astrophysics Data System (ADS)

Manrique, Pedro D.; Zheng, Minzhang; Johnson Restrepo, D. Dylan; Hui, Pak Ming; Johnson, Neil F.

What happens when you slow down the delivery of information in large-scale complex systems that operate faster than the blink of an eye? This question just adopted immediate commercial, legal and political importance following U.S. regulators' decision to allow an intentional 350 microsecond delay to be added in the ultrafast network of financial exchanges. However there is still no scientific understanding available to policymakers of the potential system-wide impact of such delays. Here we take a first step in addressing this question using a minimal model of a population of competing, heterogeneous, adaptive agents which has previously been shown to produce similar statistical features to real markets. We find that while certain extreme system-level behaviors can be prevented by such delays, the duration of others is increased. This leads to a highly non-trivial relationship between delays and system-wide instabilities which warrants deeper empirical investigation. The generic nature of our model suggests there should be a fairly wide class of complex systems where such delay-driven extreme behaviors can arise, e.g. sub-second delays in brain function possibly impacting individuals' behavior, and sub-second delays in navigational systems potentially impacting the safety of driverless vehicles.

Polyandry-fecundity relationship in insects: methodological and conceptual problems.

PubMed

Torres-Vila, L M

2013-02-01

Polyandry is perhaps the most puzzling component of mating systems because the fitness benefits for females of mating with more than one male during lifetime are poorly understood. The occurrence and extent of polyandry varies considerably both among and within species, and a positive association between polyandry and fecundity is widespread but not universal. The scenario is further complicated because the scientific literature on this issue includes studies that are often inconclusive or contradictory even for the same target species. A previous meta-analysis detected the crucial importance of two usually neglected aspects that potentially bias the interpretation of primary studies about the polyandry-fecundity relationship: the methodological approach--experimental or descriptive--and the polyandry concept itself--realized or potential. In this paper, we experimentally test the effect of these aspects with the moth Lobesia botrana. We used an innovative protocol in which the experimental and the descriptive methods were conducted simultaneously on the same target population and the results were then interpreted from the perspective of both concepts of polyandry. The results clearly showed that 1) the conclusions about the polyandry-fecundity relationship were strongly dependent on the methodological approach used and 2) the concept of polyandry invoked by the researcher was a confounding effect that potentially biases data interpretation. We suggest that greater attention must be paid to intraspecific variation among females in their propensity to remate. The differentiation in experimental studies between potentially polyandrous and monandrous phenotypes could greatly improve our knowledge about the maintenance of female mating polymorphism in most species and the adaptive significance of polyandry. © 2012 The Author. Journal of Evolutionary Biology © 2012 European Society For Evolutionary Biology.

Mapping epistemic cultures and learning potential of participants in citizen science projects.

PubMed

Vallabh, Priya; Lotz-Sisitka, Heila; O'Donoghue, Rob; Schudel, Ingrid

2016-06-01

The ever-widening scope and range of global change and interconnected systemic risks arising from people-environment relationships (social-ecological risks) appears to be increasing concern among, and involvement of, citizens in an increasingly diversified number of citizen science projects responding to these risks. We examined the relationship between epistemic cultures in citizen science projects and learning potential related to matters of concern. We then developed a typology of purposes and a citizen science epistemic-cultures heuristic and mapped 56 projects in southern Africa using this framework. The purpose typology represents the range of knowledge-production purposes, ranging from laboratory science to social learning, whereas the epistemic-cultures typology is a relational representation of scientist and citizen participation and their approach to knowledge production. Results showed an iterative relationship between matters of fact and matters of concern across the projects; the nexus of citizens' engagement in knowledge-production activities varied. The knowledge-production purposes informed and shaped the epistemic cultures of all the sampled citizen science projects, which in turn influenced the potential for learning within each project. Through a historical review of 3 phases in a long-term river health-monitoring project, we found that it is possible to evolve the learning curve of citizen science projects. This evolution involved the development of scientific water monitoring tools, the parallel development of pedagogic practices supporting monitoring activities, and situated engagement around matters of concern within social activism leading to learning-led change. We conclude that such evolutionary processes serve to increase potential for learning and are necessary if citizen science is to contribute to wider restructuring of the epistemic culture of science under conditions of expanding social-ecological risk. © 2016 Society for Conservation Biology.

Solar-Powered Electric Propulsion Systems: Engineering and Applications

NASA Technical Reports Server (NTRS)

Stearns, J. W.; Kerrisk, D. J.

1966-01-01

Lightweight, multikilowatt solar power arrays in conjunction with electric propulsion offer potential improvements to space exploration, extending the usefulness of existing launch vehicles to higher-energy missions. Characteristics of solar-powered electric propulsion missions are outlined, and preliminary performance estimates are shown. Spacecraft system engineering is discussed with respect to parametric trade-offs in power and propulsion system design. Relationships between mission performance and propulsion system performance are illustrated. The present state of the art of electric propulsion systems is reviewed and related to the mission requirements identified earlier. The propulsion system design and test requirements for a mission spacecraft are identified and discussed. Although only ion engine systems are currently available, certain plasma propulsion systems offer some advantages in over-all system design. These are identified, and goals are set for plasma-thrustor systems to make them competitive with ion-engine systems for mission applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Filinov, A.V.; Golubnychiy, V.O.; Bonitz, M.

Extending our previous work [A.V. Filinov et al., J. Phys. A 36, 5957 (2003)], we present a detailed discussion of accuracy and practical applications of finite-temperature pseudopotentials for two-component Coulomb systems. Different pseudopotentials are discussed: (i) the diagonal Kelbg potential, (ii) the off-diagonal Kelbg potential, (iii) the improved diagonal Kelbg potential, (iv) an effective potential obtained with the Feynman-Kleinert variational principle, and (v) the 'exact' quantum pair potential derived from the two-particle density matrix. For the improved diagonal Kelbg potential, a simple temperature-dependent fit is derived which accurately reproduces the 'exact' pair potential in the whole temperature range. The derivedmore » pseudopotentials are then used in path integral Monte Carlo and molecular-dynamics (MD) simulations to obtain thermodynamical properties of strongly coupled hydrogen. It is demonstrated that classical MD simulations with spin-dependent interaction potentials for the electrons allow for an accurate description of the internal energy of hydrogen in the difficult regime of partial ionization down to the temperatures of about 60 000 K. Finally, we point out an interesting relationship between the quantum potentials and the effective potentials used in density-functional theory.« less

Investigation of potential waste material insulating properties at different temperature for thermal storage application

NASA Astrophysics Data System (ADS)

Ali, T. Z. S.; Rosli, A. B.; Gan, L. M.; Billy, A. S.; Farid, Z.

2013-12-01

Thermal energy storage system (TES) is developed to extend the operation of power generation. TES system is a key component in a solar energy power generation plant, but the main issue in designing the TES system is its thermal capacity of storage materials, e.g. insulator. This study is focusing on the potential waste material acts as an insulator for thermal energy storage applications. As the insulator is used to absorb heat, it is needed to find suitable material for energy conversion and at the same time reduce the waste generation. Thus, a small-scale experimental testing of natural cooling process of an insulated tank within a confined room is conducted. The experiment is repeated by changing the insulator from the potential waste material and also by changing the heat transfer fluid (HTF). The analysis presented the relationship between heat loss and the reserved period by the insulator. The results show the percentage of period of the insulated tank withstands compared to tank insulated by foam, e.g. newspaper reserved the period of 84.6% as much as foam insulated tank to withstand the heat transfer of cooking oil to the surrounding. The paper finally justifies the most potential waste material as an insulator for different temperature range of heat transfer fluid.

Nonzero-Sum Relationships in Mitigating Urban Carbon Emissions: A Dynamic Network Simulation.

PubMed

Chen, Shaoqing; Chen, Bin; Su, Meirong

2015-10-06

The "stove-pipe" way of thinking has been mostly used in mitigating carbon emissions and managing socioeconomics because of its convenience of implementation. However, systems-oriented approaches become imperative in pursuit of an efficient regulation of carbon emissions from systems as complicated as urban systems. The aim of this paper is to establish a dynamic network approach that is capable of assessing the effectiveness of carbon emissions mitigation in a more holistic way. A carbon metabolic network is constructed by modeling the carbon flows between economic sectors and environment. With the network shocked by interventions to the sectoral carbon flows, indirect emissions from the city are accounted for under certain carbon mitigation strategies. The nonzero-sum relationships between sectors and environmental components are identified based on utility analysis, which synthesize the nature of direct and indirect network interactions. The results of the case study of Beijing suggest that the stove-pipe mitigation strategies targeted the economic sectors might be not as efficient as they were expected. A direct cutting in material or energy import to the sectors may result in a rebound in indirect emissions and thus fails to achieve the carbon mitigation goal of the city as a whole. A promising way of foreseeing the dynamic mechanism of emissions is to analyze the nonzero-sum relationships between important urban components. Thinking cities as systems of interactions, the network approach is potentially a strong tool for appraising and filtering mitigation strategies of carbon emissions.

Application of the Generalized Nonlinear Complementary Relationship for Estimating Evaporation in North China

NASA Astrophysics Data System (ADS)

Yu, M.; Wu, B.

2017-12-01

As an important part of the coupled Eco-Hydrological processes, evaporation is the bond for exchange of energy and heat between the surface and the atmosphere. However, the estimation of evaporation remains a challenge compared with other main hydrological factors in water cycle. The complementary relationship which proposed by Bouchet (1963) has laid the foundation for various approaches to estimate evaporation from land surfaces, the essence of the principle is a relationship between three types of evaporation in the environment. It can simply implemented with routine meteorological data without the need for resistance parameters of the vegetation and bare land, which are difficult to observed and complicated to estimate in most surface flux models. On this basis the generalized nonlinear formulation was proposed by Brutsaert (2015). The daily evaporation can be estimated once the potential evaporation (Epo) and apparent potential evaporation (Epa) are known. The new formulation has a strong physical basis and can be expected to perform better under natural water stress conditions, nevertheless, the model has not been widely validated over different climate types and underlying surface patterns. In this study, we attempted to apply the generalized nonlinear complementary relationship in North China, three flux stations in North China are used for testing the universality and accuracy of this model against observed evaporation over different vegetation types, including Guantao Site, Miyun Site and Huailai Site. Guantao Site has double-cropping systems and crop rotations with summer maize and winter wheat; the other two sites are dominated by spring maize. Detailed measurements of meteorological factors at certain heights above ground surface from automatic weather stations offered necessary parameters for daily evaporation estimation. Using the Bowen ratio, the surface energy measured by the eddy covariance systems at the flux stations is adjusted on a daily scale to satisfy the surface energy closure. After calibration the estimated daily evaporation are in good agreement with EC-measured flux data with a mean correlation coefficient in excess of 0.85. The results indicate that the generalized nonlinear complementary relationship can be applied in plant growing and non-growing season in North China.

Quasi-steady-state analysis of coupled flashing ratchets.

PubMed

Levien, Ethan; Bressloff, Paul C

2015-10-01

We perform a quasi-steady-state (QSS) reduction of a flashing ratchet to obtain a Brownian particle in an effective potential. The resulting system is analytically tractable and yet preserves essential dynamical features of the full model. We first use the QSS reduction to derive an explicit expression for the velocity of a simple two-state flashing ratchet. In particular, we determine the relationship between perturbations from detailed balance, which are encoded in the transitions rates of the flashing ratchet, and a tilted-periodic potential. We then perform a QSS analysis of a pair of elastically coupled flashing ratchets, which reduces to a Brownian particle moving in a two-dimensional vector field. We suggest that the fixed points of this vector field accurately approximate the metastable spatial locations of the coupled ratchets, which are, in general, impossible to identify from the full system.

Worldwide distribution and diversity of seabird ticks: implications for the ecology and epidemiology of tick-borne pathogens.

PubMed

Dietrich, Muriel; Gómez-Díaz, Elena; McCoy, Karen D

2011-05-01

The ubiquity of ticks and their importance in the transmission of pathogens involved in human and livestock diseases are reflected by the growing number of studies focusing on tick ecology and the epidemiology of tick-borne pathogens. Likewise, the involvement of wild birds in dispersing pathogens and their role as reservoir hosts are now well established. However, studies on tick-bird systems have mainly focused on land birds, and the role of seabirds in the ecology and epidemiology of tick-borne pathogens is rarely considered. Seabirds typically have large population sizes, wide geographic distributions, and high mobility, which make them significant potential players in the maintenance and dispersal of disease agents at large spatial scales. They are parasitized by at least 29 tick species found across all biogeographical regions of the world. We know that these seabird-tick systems can harbor a large diversity of pathogens, although detailed studies of this diversity remain scarce. In this article, we review current knowledge on the diversity and global distribution of ticks and tick-borne pathogens associated with seabirds. We discuss the relationship between seabirds, ticks, and their pathogens and examine the interesting characteristics of these relationships from ecological and epidemiological points of view. We also highlight some future research directions required to better understand the evolution of these systems and to assess the potential role of seabirds in the epidemiology of tick-borne pathogens.

[Relationship between magnocellular function and reading skills in children: a study using visual evoked potentials].

PubMed

Kobayashi, Tomoka; Inagaki, Masumi; Yamazaki, Hiroko; Kita, Yosuke; Kaga, Makiko; Oka, Akira

2014-11-01

Developmental dyslexia (DD) is a neurodevelopmental disorder that is characterized by difficulties with accurate and/or fluent word recognition and by poor spelling and decoding abilities. The magnocellular deficit theory is one of several hypotheses that have been proposed to explain the pathophysiology of DD. In this study, we investigated magnocellular system dysfunction in Japanese dyslexic children. Subjects were 19 dyslexic children (DD group) and 19 aged-matched healthy children (TD group). They were aged between 7 and 16 years. Reversed patterns of black and white sinusoidal gratings generated at a low spatial frequency, high reversal frequency of 7.5 Hz, and low contrasts were used specifically to stimulate the magnocellular system. We recorded visual evoked potentials (VEP) from the occipital area and examined their relationship with reading and naming tasks, such as the time to read hiragana characters, rapid automatized naming of pictured objects, and phonological manipulation. Compared to the TD group, the DD group showed a significantly lower peak amplitude of VEPs through the complex demodulation method. Structural equation modeling showed that VEP peak amplitudes were related to the rapid automatized naming of pictured objects, and better rapid automatized naming resulted in higher reading skills. There was no correlation between VEP findings and the capacity for phonological manipulation. VEPs in response to the magnocellular system are useful for understanding the pathophysiology of DD. Single phonological deficit may not be sufficient to cause DD.

The challenge of compliance and persistence: focus on ulcerative colitis.

PubMed

Kane, Sunanda V; Brixner, Diana; Rubin, David T; Sewitch, Maida J

2008-01-01

Non-adherence to therapy is a widespread problem, with typical adherence rates for prescribed medications being approximately 50%. An estimated 20% to 50% of patients with ulcerative colitis (UC) do not take their medications as prescribed, resulting in higher disease-recurrence rates and potentially higher health care costs. To characterize the problem of non-adherence in UC, to review the many factors affecting compliance and persistence in this population, and to discuss practical strategies to improve adherence in these patients. Adherence to and persistence with medication are complex and multifactorial behaviors. Factors shown to affect adherence in UC patients include disease extent and duration, cost of medications, fear of adverse effects, individual psychosocial variables, and the patient-physician relationship. In contrast, recent data do not support an important role for treatment-related factors such as daily dose, regimen, and formulation in influencing adherence in this population, particularly with longer duration of use. Strategies to improve adherence should involve the patient, the provider, and the health care delivery system. For UC patients, knowledge and discussion of the rationale for supporting persistence, such as recent data regarding agents that have a potential chemoprotective benefit, may encourage persistence, even during periods of quiescence. The patient-physician relationship is critical in encouraging adherence, particularly with respect to education, open communication, and agreement regarding the value of the assigned treatment. Health care delivery systems can improve adherence by encouraging the participation of multidisciplinary teams, providing reporting and tracking systems, and eliminating financial barriers where possible.

Social Adversity and Antisocial Behavior: Mediating Effects of Autonomic Nervous System Activity.

PubMed

Fagan, Shawn E; Zhang, Wei; Gao, Yu

2017-11-01

The display of antisocial behaviors in children and adolescents has been of interest to criminologists and developmental psychologists for years. Exposure to social adversity is a well-documented predictor of antisocial behavior. Additionally, measures of autonomic nervous system (ANS) activity, including heart rate variability (HRV), pre-ejection period (PEP), and heart rate, have been associated with antisocial behaviors including rule-breaking and aggression. Social neuroscience research has begun to investigate how neurobiological underpinnings affect the relationship between social adversity and antisocial/psychopathic behavior in children and adolescents. This study investigated the potential mediating effects of ANS activity on the relationship between social adversity and antisocial behavior in a group of 7- to 10-year-old children from the community (N = 339; 48.2% male). Moderated multiple mediation analyses revealed that low resting heart rate, but not PEP or HRV, mediated the relationship between social adversity and antisocial behavior in males only. Social adversity but not ANS measures were associated with antisocial behavior in females. Findings have implications for understanding the neural influences that underlie antisocial behavior, illustrate the importance of the social environment regarding the expression of these behaviors, and highlight essential gender differences.

Light during darkness and cancer: relationships in circadian photoreception and tumor biology.

PubMed

Jasser, Samar A; Blask, David E; Brainard, George C

2006-05-01

The relationship between circadian phototransduction and circadian-regulated processes is poorly understood. Melatonin, commonly a circadian phase marker, may play a direct role in a myriad of physiologic processes. The circadian rhythm for pineal melatonin secretion is regulated by the hypothalamic suprachiasmatic nucleus (SCN). Its neural source of light input is a unique subset of intrinsically photosensitive retinal ganglion cells expressing melanopsin, the primary circadian photopigment in rodents and primates. Action spectra of melatonin suppression by light have shown that light in the 446-477 nm range, distinct from the visual system's peak sensitivity, is optimal for stimulating the human circadian system. Breast cancer is the oncological disease entity whose relationship to circadian rhythm fluctuations has perhaps been most extensively studied. Empirical data has increasingly supported the hypothesis that higher risk of breast cancer in industrialized countries is partly due to increased exposure to light at night. Studies of tumor biology implicate melatonin as a potential mediator of this effect. Yet, causality between lifestyle factors and circadian tumor biology remains elusive and likely reflects significant variability with physiologic context. Continued rigorous empirical inquiry into the physiology and clinical implications of these habitual, integrated aspects of life is highly warranted at this time.

Relationships between host body condition and immunocompetence, not host sex, best predict parasite burden in a bat-helminth system.

PubMed

Warburton, Elizabeth M; Pearl, Christopher A; Vonhof, Maarten J

2016-06-01

Sex-biased parasitism highlights potentially divergent approaches to parasite resistance resulting in differing energetic trade-offs for males and females; however, trade-offs between immunity and self-maintenance could also depend on host body condition. We investigated these relationships in the big brown bat, Eptesicus fuscus, to determine if host sex or body condition better predicted parasite resistance, if testosterone levels predicted male parasite burdens, and if immune parameters could predict male testosterone levels. We found that male and female hosts had similar parasite burdens and female bats scored higher than males in only one immunological measure. Top models of helminth burden revealed interactions between body condition index and agglutination score as well as between agglutination score and host sex. Additionally, the strength of the relationships between sex, agglutination, and helminth burden is affected by body condition. Models of male parasite burden provided no support for testosterone predicting helminthiasis. Models that best predicted testosterone levels did not include parasite burden but instead consistently included month of capture and agglutination score. Thus, in our system, body condition was a more important predictor of immunity and worm burden than host sex.

Parent-related mechanisms underlying the social gradient of childhood overweight and obesity: a systematic review.

PubMed

Mech, P; Hooley, M; Skouteris, H; Williams, J

2016-09-01

Low socio-economic status (SES) is a significant risk factor for childhood overweight and obesity (COWOB) in high-income countries. Parents to young children buffer and accentuate social and cultural influences, and are central to the development of this disease. An understanding of the parent-related mechanisms that underlie the SES-COWOB relationship is needed to improve the efficacy of prevention and intervention efforts. A systematic review of relevant literature was conducted to investigate the mechanisms by which levels of SES (low, middle and high) are associated to COWOB, by exploring mediation and interaction effects. Six electronic databases were searched yielding 5155 initial records, once duplicates were removed. Studies were included if they investigated COWOB, SES, parent-related factors and the multivariate relationship between these factors. Thirty studies were included. Factors found to be mediating the SES-COWOB relationship or interacting with SES to influence COWOB were categorized according to an ecological systems framework, at child, parent, household and social system level factors. High parent body mass index, ethnicity, child-care attendance, high TV time (mother and child), breastfeeding (early weaning), food intake behaviours and birthweight potentially mediate the relationship between SES and COWOB. Different risk factors for COWOB in different SES groups were found. For low SES families, parental obesity and maternal depressive symptoms were strong risk factors for COWOB, whereas long maternal working hours and a permissive parenting style were risk factors for higher SES families. None of the studies investigated parental psychological attributes such as attitudes, beliefs, self-esteem and so on as potential mechanisms/risk factors. Families from different SES groups have different risk and protective factors for COWOB. Prevention and intervention efforts may have improved efficacy if they are tailored to address specific risk factors within SES. © 2016 John Wiley & Sons Ltd.

Ubiquitous Geo-Sensing for Context-Aware Analysis: Exploring Relationships between Environmental and Human Dynamics

PubMed Central

Sagl, Günther; Blaschke, Thomas; Beinat, Euro; Resch, Bernd

2012-01-01

Ubiquitous geo-sensing enables context-aware analyses of physical and social phenomena, i.e., analyzing one phenomenon in the context of another. Although such context-aware analysis can potentially enable a more holistic understanding of spatio-temporal processes, it is rarely documented in the scientific literature yet. In this paper we analyzed the collective human behavior in the context of the weather. We therefore explored the complex relationships between these two spatio-temporal phenomena to provide novel insights into the dynamics of urban systems. Aggregated mobile phone data, which served as a proxy for collective human behavior, was linked with the weather data from climate stations in the case study area, the city of Udine, Northern Italy. To identify and characterize potential patterns within the weather-human relationships, we developed a hybrid approach which integrates several spatio-temporal statistical analysis methods. Thereby we show that explanatory factor analysis, when applied to a number of meteorological variables, can be used to differentiate between normal and adverse weather conditions. Further, we measured the strength of the relationship between the ‘global’ adverse weather conditions and the spatially explicit effective variations in user-generated mobile network traffic for three distinct periods using the Maximal Information Coefficient (MIC). The analyses result in three spatially referenced maps of MICs which reveal interesting insights into collective human dynamics in the context of weather, but also initiate several new scientific challenges. PMID:23012571

Evolutionary distance from human homologs reflects allergenicity of animal food proteins.

PubMed

Jenkins, John A; Breiteneder, Heimo; Mills, E N Clare

2007-12-01

In silico analysis of allergens can identify putative relationships among protein sequence, structure, and allergenic properties. Such systematic analysis reveals that most plant food allergens belong to a restricted number of protein superfamilies, with pollen allergens behaving similarly. We have investigated the structural relationships of animal food allergens and their evolutionary relatedness to human homologs to define how closely a protein must resemble a human counterpart to lose its allergenic potential. Profile-based sequence homology methods were used to classify animal food allergens into Pfam families, and in silico analyses of their evolutionary and structural relationships were performed. Animal food allergens could be classified into 3 main families--tropomyosins, EF-hand proteins, and caseins--along with 14 minor families each composed of 1 to 3 allergens. The evolutionary relationships of each of these allergen superfamilies showed that in general, proteins with a sequence identity to a human homolog above approximately 62% were rarely allergenic. Single substitutions in otherwise highly conserved regions containing IgE epitopes in EF-hand parvalbumins may modulate allergenicity. These data support the premise that certain protein structures are more allergenic than others. Contrasting with plant food allergens, animal allergens, such as the highly conserved tropomyosins, challenge the capability of the human immune system to discriminate between foreign and self-proteins. Such immune responses run close to becoming autoimmune responses. Exploiting the closeness between animal allergens and their human homologs in the development of recombinant allergens for immunotherapy will need to consider the potential for developing unanticipated autoimmune responses.

An analysis of household waste management policy using system dynamics modelling.

PubMed

Inghels, Dirk; Dullaert, Wout

2011-04-01

This paper analyses the Flemish household waste management policy. Based on historical data from the period 1991-2006, literature reviews and interviews, both mathematical and descriptive relationships are derived that describe Flemish waste collection, reuse, recycling and disposal behaviour. This provides insights into how gross domestic product (GDP), population and selective collection behaviour have influenced household waste production and collection over time. These relationships are used to model the dynamic relationships underlying household waste management in Flanders by using a system dynamics (SD) modelling approach. Where most SD models in literature are conceptual and descriptive, in the present study a real-life case with both correlational and descriptive relationships was modelled for Flanders, a European region with an outstanding waste management track record. This model was used to evaluate the current Flemish household waste management policy based on the principles of the waste hierarchy, also referred as the Lansink ranking. The results show that Flemish household waste targets up to 2015 can be achieved by the current waste policy measures. It also shows the sensitivity of some key policy parameters such as prevention and reuse. Given the general nature of the model and its limited data requirements, the authors believe that the approach implemented in this model can also assist waste policy makers in other regions or countries to meet their policy targets by simulating the effect of their current and potential household waste policy measures.

Groundwater productivity potential mapping using evidential belief function.

PubMed

Park, Inhye; Kim, Yongsung; Lee, Saro

2014-09-01

The evidential belief function (EBF) model was applied and validated for analysis of groundwater-productivity potential (GPP) in Boryeong and Pohang cities, agriculture region in Korea using geographic information systems (GIS). Data about related factors, including topography, lineament, geology, forest, soil, and groundwater data were collected and input into a spatial database. Additionally, in the Boryeong area, specific capacity (SPC) data not lower than 4.55 m3 /d/m were collected, corresponding to 300 m3 /d yield from 72 well locations. In the Pohang area, SPC data of ≥ 6.25 m3 /d/m were collected, corresponding to a yield of 500 m3 /d from 44 well locations. By using the constructed spatial database, 19 factors related to groundwater productivity were extracted. The relationships between the well locations and the factors were identified and quantified by using the EBF model. Four relationships were calculated: belief (Bel), disbelief (Dis), uncertainty (Unc), and plausibility (Pls). The relationships were used as factor ratings in the overlay analysis to create GPP indices and maps. The resulting GPP maps showed 83.41% and 77.53% accuracy in Boryeong and Pohang areas, respectively. The EBF model was found to be more effective in terms of prediction accuracy. © 2014, National Ground Water Association.

Strategic planning for MyRA performance: A causal loop diagram approach

NASA Astrophysics Data System (ADS)

Abidin, Norhaslinda Zainal; Zaibidi, Nerda Zura; Karim, Khairah Nazurah

2017-10-01

The nexus of research and innovation in higher education are continually receiving worldwide priority attention. Hence, Malaysia has taken its move to enhance public universities as a center of excellence by introducing the status of Research University (RU). To inspire all universities towards becoming a research university, The Ministry of Higher Education (MoHE) had revised an assessment called Malaysian Research Assessment Instrument (MyRA) to evaluate the performance of existence RUs, and other potential higher education institutions. The available spreadsheet tool to access MyRA performance is inadequate to support strategic planning. Since, higher education management is a complex system, in which components and their interactions are ever changing over time, there is a need to for an efficient approach to investigate system behavior and devise research management policies for the benefit of the institution itself and the higher education system. In this paper, we proposed a system dynamics simulation model to evaluate the impact of policies for obtaining the highest performance in MyRA assessment. Causal loop diagram is developed to investigate the relationship of various elements in research management, their inter-relationship that link together and their evolution of behavior over time.

Theoretical insights on the antioxidant activity of edaravone free radical scavengers derivatives

NASA Astrophysics Data System (ADS)

Cerón-Carrasco, José P.; Roy, Hélène M.; Cerezo, Javier; Jacquemin, Denis; Laurent, Adèle D.

2014-04-01

The prediction of antioxidant properties is not straightforward due to the complexity of the in vivo systems. Here, we use theoretical descriptors, including the potential of ionization, the electrodonating power and the spin density distribution, to characterize the antioxidant capacity of edaravone (EDV) derivatives. Our computations reveal the relationship between these parameters and their potential bioactivity as free radical scavengers. We conclude that more efficient antioxidants could be synthesized by tuning the R1 and R2 positions of the EDV structure, rather than modifying the R3 group. Such modifications might improve the antioxidant activity in neutral and deprotonated forms.

The roles of users personal characteristics and organisational support in the attitude towards using ERP systems in a Spanish public hospital.

PubMed

Escobar-Rodriguez, Tomas; Bartual-Sopena, Lourdes

Enterprise resources planning (ERP) systems enable central and integrative control over all processes throughout an organisation by ensuring one data entry point and the use of a common database. T his paper analyses the attitude of healthcare personnel towards the use of an ERP system in a Spanish public hospital, identifying influencing factors. This research is based on a regression analysis of latent variables using the optimisation technique of partial least squares. We propose a research model including possible relationships among different constructs using the technology acceptance model. Our results show that the personal characteristics of potential users are key factors in explaining attitude towards using ERP systems.

A Framework of Complex Adaptive Systems: Parents As Partners in the Neonatal Intensive Care Unit.

PubMed

DʼAgata, Amy L; McGrath, Jacqueline M

2016-01-01

Advances in neonatal care are allowing for increased infant survival; however, neurodevelopmental complications continue. Using a complex adaptive system framework, a broad analysis of the network of agents most influential to vulnerable infants in the neonatal intensive care unit (NICU) is presented: parent, nurse, and organization. By exploring these interconnected relationships and the emergent behaviors, a model of care that increases parental caregiving in the NICU is proposed. Supportive parent caregiving early in an infant's NICU stay has the potential for more sensitive caregiving and enhanced opportunities for attachment, perhaps positively impacting neurodevelopment.

Transactions within the family: Coparenting mediates associations between parents' relationship satisfaction and the parent-child relationship.

PubMed

Peltz, Jack S; Rogge, Ronald D; Sturge-Apple, Melissa L

2018-06-21

In the current study, we examined the potential for transactional relations among parents' marital satisfaction, coparental cooperation and conflict, and parent-child relationship satisfaction in a sample of 249 families with 2-3-year-old children. Using a novel multiwave design with frequent assessments to better capture transactional family processes, mothers and fathers were assessed across 5 waves with 2-month lags; mean age of the target children (53% girls) was 2.8 years ( SD = 0.62) at baseline. Cross-lagged, multilevel structural equation modeling (SEM) analyses using an actor-partner interdependence modeling framework revealed coparental cooperation and conflict as likely mechanisms within the family system. Specifically, marital satisfaction from both parents was reciprocally linked to fathers' coparental cooperation over time, supporting transactional links between those two family subsystems. In addition, there were significant transactional links between both mothers' and fathers' coparental cooperation and father-reported parent-child relationship satisfaction across time, revealing within-parent and cross-parent mediation. Regarding coparental conflict, marital satisfaction from both parents was reciprocally linked to the same parents' reports of coparental conflict across time (i.e., actor effects). Furthermore, father-reported coparental conflict acted as a mediating or intervening mechanism between father-reported marital satisfaction and mother-reported parent-child relationship satisfaction (cross-parent mediation). Taken as a set, the findings supported coparental cooperation and conflict as significant links between marital functioning and the parent-child relationship. Findings build on a growing body of literature addressing the transactional associations embedded within the family system and highlight the importance of modeling the inherent interdependencies between mothers' and fathers' reports of family functioning. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Social relationships and social support among post-war youth in Northern Uganda.

PubMed

De Nutte, Leen; Okello, James; Derluyn, Ilse

2017-08-01

Although social relationships and social support are salient factors for post-war adolescents' psychosocial coping and adjustment, there is only limited information regarding war-affected adolescents' views on social support and the relationships within which social support is provided. This study therefore explored both elements among a clinical sample of 20 adolescents living in post-war Northern Uganda. Following Braun and Clarke's thematic analysis, we found a prominent role of the biological mother and other primary biological family members in the upbringing of our participants. Spiritual and material support were perceived to be the most important type of support, respectively, while the adolescents were growing up and in their current lives. These findings provide support for the perception that caregiving systems are adaptable to particular sociocultural contexts. Further, the importance of particular functions of social support could signify a potentially selective buffering effect of these functions in adverse contexts. Because of the importance of the primary biological family and the salient role of parent-child relationships in the face of adversity, future research needs to focus on this particular kind of social relationship in contexts of prolonged collective violence. © 2015 International Union of Psychological Science.

A systems-genetics approach and data mining tool to assist in the discovery of genes underlying complex traits in Oryza sativa.

PubMed

Ficklin, Stephen P; Feltus, Frank Alex

2013-01-01

Many traits of biological and agronomic significance in plants are controlled in a complex manner where multiple genes and environmental signals affect the expression of the phenotype. In Oryza sativa (rice), thousands of quantitative genetic signals have been mapped to the rice genome. In parallel, thousands of gene expression profiles have been generated across many experimental conditions. Through the discovery of networks with real gene co-expression relationships, it is possible to identify co-localized genetic and gene expression signals that implicate complex genotype-phenotype relationships. In this work, we used a knowledge-independent, systems genetics approach, to discover a high-quality set of co-expression networks, termed Gene Interaction Layers (GILs). Twenty-two GILs were constructed from 1,306 Affymetrix microarray rice expression profiles that were pre-clustered to allow for improved capture of gene co-expression relationships. Functional genomic and genetic data, including over 8,000 QTLs and 766 phenotype-tagged SNPs (p-value < = 0.001) from genome-wide association studies, both covering over 230 different rice traits were integrated with the GILs. An online systems genetics data-mining resource, the GeneNet Engine, was constructed to enable dynamic discovery of gene sets (i.e. network modules) that overlap with genetic traits. GeneNet Engine does not provide the exact set of genes underlying a given complex trait, but through the evidence of gene-marker correspondence, co-expression, and functional enrichment, site visitors can identify genes with potential shared causality for a trait which could then be used for experimental validation. A set of 2 million SNPs was incorporated into the database and serve as a potential set of testable biomarkers for genes in modules that overlap with genetic traits. Herein, we describe two modules found using GeneNet Engine, one with significant overlap with the trait amylose content and another with significant overlap with blast disease resistance.

A Systems-Genetics Approach and Data Mining Tool to Assist in the Discovery of Genes Underlying Complex Traits in Oryza sativa

PubMed Central

Ficklin, Stephen P.; Feltus, Frank Alex

2013-01-01

Many traits of biological and agronomic significance in plants are controlled in a complex manner where multiple genes and environmental signals affect the expression of the phenotype. In Oryza sativa (rice), thousands of quantitative genetic signals have been mapped to the rice genome. In parallel, thousands of gene expression profiles have been generated across many experimental conditions. Through the discovery of networks with real gene co-expression relationships, it is possible to identify co-localized genetic and gene expression signals that implicate complex genotype-phenotype relationships. In this work, we used a knowledge-independent, systems genetics approach, to discover a high-quality set of co-expression networks, termed Gene Interaction Layers (GILs). Twenty-two GILs were constructed from 1,306 Affymetrix microarray rice expression profiles that were pre-clustered to allow for improved capture of gene co-expression relationships. Functional genomic and genetic data, including over 8,000 QTLs and 766 phenotype-tagged SNPs (p-value < = 0.001) from genome-wide association studies, both covering over 230 different rice traits were integrated with the GILs. An online systems genetics data-mining resource, the GeneNet Engine, was constructed to enable dynamic discovery of gene sets (i.e. network modules) that overlap with genetic traits. GeneNet Engine does not provide the exact set of genes underlying a given complex trait, but through the evidence of gene-marker correspondence, co-expression, and functional enrichment, site visitors can identify genes with potential shared causality for a trait which could then be used for experimental validation. A set of 2 million SNPs was incorporated into the database and serve as a potential set of testable biomarkers for genes in modules that overlap with genetic traits. Herein, we describe two modules found using GeneNet Engine, one with significant overlap with the trait amylose content and another with significant overlap with blast disease resistance. PMID:23874666

Voltage-dependent Ca2+ release from the SR of feline ventricular myocytes is explained by Ca2+-induced Ca2+ release.

PubMed

Piacentino, V; Dipla, K; Gaughan, J P; Houser, S R

2000-03-15

1. Direct voltage-gated (voltage-dependent Ca2+ release, VDCR) and Ca2+ influx-gated (Ca2+-induced Ca2+ release, CICR) sarcoplasmic reticulum (SR) Ca2+ release were studied in feline ventricular myocytes. The voltage-contraction relationship predicted by the VDCR hypothesis is sigmoidal with large contractions at potentials near the Ca2+ equilibrium potential (ECa). The relationship predicted by the CICR hypothesis is bell-shaped with no contraction at ECa. 2. The voltage dependence of contraction was measured in ventricular myocytes at physiological temperature (37 C), resting membrane potential and physiological [K+]. Experiments were performed with cyclic adenosine 3',5'-monophosphate (cAMP) in the pipette or in the presence of the beta-adrenergic agonist isoproterenol (isoprenaline; ISO). 3. The voltage-contraction relationship was bell-shaped in Na+-free solutions (to eliminate the Na+ current and Na+-Ca2+ exchange, NCX) but the relationship was broader than the L-type Ca2+ current (ICa,L)-voltage relationship. 4. Contractions induced with voltage steps from normal resting potentials to -40 mV are thought to represent VDCR rather than CICR. We found that cAMP and ISO shifted the voltage dependence of ICa,L activation to more negative potentials so that ICa,L was always present with steps to -40 mV. ICa,L at -40 mV inactivated when the holding potential was decreased (VŁ = -57.8 +/- 0.49 mV). 5. ISO increased inward current, SR Ca2+ load and contraction in physiological [Na+] and a broad bell-shaped voltage-contraction relationship was observed. Inhibition of reverse-mode NCX, decreasing ICa,L and decreasing SR Ca2+ loading all decreased contractions at strongly positive potentials near ECa. 6. The voltage-contraction relationship in 200 microM cadmium (Cd2+) was bell-shaped, supporting a role of ICa,L rather than VDCR. 7. All results could be accounted for by the CICR hypothesis, and many results exclude the VDCR hypothesis.

[Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases].

PubMed

Schaible, H-G; Chang, H-D; Grässel, S; Haibel, H; Hess, A; Kamradt, T; Radbruch, A; Schett, G; Stein, C; Straub, R H

2018-05-01

The research consortium Neuroimmunology and Pain (Neuroimpa) explores the importance of the relationships between the immune system and the nervous system in musculoskeletal diseases for the generation of pain and for the course of fracture healing and arthritis. The spectrum of methods includes analyses at the single cell level, in vivo models of arthritis and fracture healing, imaging studies on brain function in animals and humans and analysis of data from patients. Proinflammatory cytokines significantly contribute to the generation of joint pain through neuronal cytokine receptors. Immune cells release opioid peptides which activate opioid receptors at peripheral nociceptors and thereby evoke hypoalgesia. The formation of new bone after fractures is significantly supported by the nervous system. The sympathetic nervous system promotes the development of immune-mediated arthritis. The studies show a significant analgesic potential of the neutralization of proinflammatory cytokines and of opioids which selectively inhibit peripheral neurons. Furthermore, they show that the modulation of neuronal mechanisms can beneficially influence the course of musculoskeletal diseases. Interventions in the interactions between the immune system and the nervous system hold a great therapeutic potential for the treatment of musculoskeletal diseases and pain.

Neural Basis of Emotional Decision Making in Trait Anxiety

PubMed Central

Xu, Pengfei; Gu, Ruolei; Broster, Lucas S.; Wu, Runguo; Van Dam, Nicholas T.; Jiang, Yang; Fan, Jin

2013-01-01

Although trait anxiety has been associated with risk decision making, whether it is related to risk per se or to the feeling of the risk, as well as the underlying neurocognitive mechanisms, remains unclear. Using a decision-making task with a manipulation of frame (i.e., written description of options as a potential gain or loss) and functional magnetic resonance imaging, we investigated the neurocognitive relationship between trait anxiety and decision making. The classic framing effect was observed: participants chose the safe option when it was described as a potential gain, but they avoided the same option when it was described as a potential loss. Most importantly, trait anxiety was positively correlated with this behavioral bias. Trait anxiety was also positively correlated with amygdala-based “emotional” system activation and its coupling with the ventromedial prefrontal cortex (vmPFC) when decisions were consistent with the framing effect, but negatively correlated with the dorsal anterior cingulate cortex (dACC)-based “analytic” system activation and its connectivity to the vmPFC when decisions ran counter to the framing effect. Our findings suggest that trait anxiety is not associated with subjective risk preference but an evaluative bias of emotional information in decision making, underpinned by a hyperactive emotional system and a hypoactive analytic system in the brain. PMID:24259585

Neural basis of emotional decision making in trait anxiety.

PubMed

Xu, Pengfei; Gu, Ruolei; Broster, Lucas S; Wu, Runguo; Van Dam, Nicholas T; Jiang, Yang; Fan, Jin; Luo, Yue-jia

2013-11-20

Although trait anxiety has been associated with risk decision making, whether it is related to risk per se or to the feeling of the risk, as well as the underlying neurocognitive mechanisms, remains unclear. Using a decision-making task with a manipulation of frame (i.e., written description of options as a potential gain or loss) and functional magnetic resonance imaging, we investigated the neurocognitive relationship between trait anxiety and decision making. The classic framing effect was observed: participants chose the safe option when it was described as a potential gain, but they avoided the same option when it was described as a potential loss. Most importantly, trait anxiety was positively correlated with this behavioral bias. Trait anxiety was also positively correlated with amygdala-based "emotional" system activation and its coupling with the ventromedial prefrontal cortex (vmPFC) when decisions were consistent with the framing effect, but negatively correlated with the dorsal anterior cingulate cortex (dACC)-based "analytic" system activation and its connectivity to the vmPFC when decisions ran counter to the framing effect. Our findings suggest that trait anxiety is not associated with subjective risk preference but an evaluative bias of emotional information in decision making, underpinned by a hyperactive emotional system and a hypoactive analytic system in the brain.

High-performance radial AMTEC cell design for ultra-high-power solar AMTEC systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendricks, T.J.; Huang, C.

1999-07-01

Alkali Metal Thermal to Electric Conversion (AMTEC) technology is rapidly maturing for potential application in ultra-high-power solar AMTEC systems required by potential future US Air Force (USAF) spacecraft missions in medium-earth and geosynchronous orbits (MEO and GEO). Solar thermal AMTEC power systems potentially have several important advantages over current solar photovoltaic power systems in ultra-high-power spacecraft applications for USAF MEO and GEO missions. This work presents key aspects of radial AMTEC cell design to achieve high cell performance in solar AMTEC systems delivering larger than 50 kW(e) to support high power USAF missions. These missions typically require AMTEC cell conversionmore » efficiency larger than 25%. A sophisticated design parameter methodology is described and demonstrated which establishes optimum design parameters in any radial cell design to satisfy high-power mission requirements. Specific relationships, which are distinct functions of cell temperatures and pressures, define critical dependencies between key cell design parameters, particularly the impact of parasitic thermal losses on Beta Alumina Solid Electrolyte (BASE) area requirements, voltage, number of BASE tubes, and system power production for both maximum power-per-BASE-area and optimum efficiency conditions. Finally, some high-level system tradeoffs are demonstrated using the design parameter methodology to establish high-power radial cell design requirements and philosophy. The discussion highlights how to incorporate this methodology with sophisticated SINDA/FLUINT AMTEC cell modeling capabilities to determine optimum radial AMTEC cell designs.« less

Electroactive Biofilms: Current Status and Future Research Needs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borole, Abhijeet P; Reguera, Gemma; Ringeisen, Bradley

2011-01-01

Electroactive biofilms generated by electrochemically active microorganisms have many potential applications in bioenergy and chemicals production. This review assesses the effects of microbiological and process parameters on enrichment of such biofilms as well as critically evaluates the current knowledge of the mechanisms of extracellular electron transfer in BES systems. First we discuss the role of biofilm forming microorganisms vs. planktonic microorganisms. Physical, chemical and electrochemical parameters which dictate the enrichment and subsequent performance of the biofilms are discussed. Potential dependent biological parameters including biofilm growth rate, specific electron transfer rate and others and their relationship to BES system performance ismore » assessed. A review of the mechanisms of electron transfer in BES systems is included followed by a discussion of biofilm and its exopolymeric components and their electrical conductivity. A discussion of the electroactive biofilms in biocathodes is also included. Finally, we identify the research needs for further development of the electroactive biofilms to enable commercial applications.« less

Diagnosing Breast Cancer with Microwave Technology: remaining challenges and potential solutions with machine learning.

PubMed

Oliveira, Bárbara L; Godinho, Daniela; O'Halloran, Martin; Glavin, Martin; Jones, Edward; Conceição, Raquel C

2018-05-19

Currently, breast cancer often requires invasive biopsies for diagnosis, motivating researchers to design and develop non-invasive and automated diagnosis systems. Recent microwave breast imaging studies have shown how backscattered signals carry relevant information about the shape of a tumour, and tumour shape is often used with current imaging modalities to assess malignancy. This paper presents a comprehensive analysis of microwave breast diagnosis systems which use machine learning to learn characteristics of benign and malignant tumours. The state-of-the-art, the main challenges still to overcome and potential solutions are outlined. Specifically, this work investigates the benefit of signal pre-processing on diagnostic performance, and proposes a new set of extracted features that capture the tumour shape information embedded in a signal. This work also investigates if a relationship exists between the antenna topology in a microwave system and diagnostic performance. Finally, a careful machine learning validation methodology is implemented to guarantee the robustness of the results and the accuracy of performance evaluation.

Evaluating models of object-decision priming: evidence from event-related potential repetition effects.

PubMed

Soldan, Anja; Mangels, Jennifer A; Cooper, Lynn A

2006-03-01

This study was designed to differentiate between structural description and bias accounts of performance in the possible/impossible object-decision test. Two event-related potential (ERP) studies examined how the visual system processes structurally possible and impossible objects. Specifically, the authors investigated the effects of object repetition on a series of early posterior components during structural (Experiment 1) and functional (Experiment 2) encoding and the relationship of these effects to behavioral measures of priming. In both experiments, the authors found repetition enhancement of the posterior N1 and N2 for possible objects only. In addition, the magnitude of the N1 repetition effect for possible objects was correlated with priming for possible objects. Although the behavioral results were more ambiguous, these ERP results fail to support bias models that hold that both possible and impossible objects are processed similarly in the visual system. Instead, they support the view that priming is supported by a structural description system that encodes the global 3-dimensional structure of an object.

The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain.

PubMed

Kanji, S; Fonseka, T M; Marshe, V S; Sriretnakumar, V; Hahn, M K; Müller, D J

2018-02-01

With the emergence of knowledge implicating the human gut microbiome in the development and regulation of several physiological systems, evidence has accumulated to suggest a role for the gut microbiome in psychiatric conditions and drug response. A complex relationship between the enteric nervous system, the gut microbiota and the central nervous system has been described which allows for the microbiota to influence and respond to a variety of behaviors and psychiatric conditions. Additionally, the use of pharmaceuticals may interact with and alter the microbiota to potentially contribute to adverse effects of the drug. The gut microbiota has been described in several psychiatric disorders including depression and anxiety, but only a few reports have discussed the role of the microbiome in schizophrenia. The following review examines the evidence surrounding the gut microbiota in behavior and psychiatric illness, the role of the microbiota in schizophrenia and the potential for antipsychotics to alter the gut microbiota and promote adverse metabolic events.

The Potential of Micro Electro Mechanical Systems and Nanotechnology for the U.S. Army

DTIC Science & Technology

2001-05-01

Quantitative Structure Activity Relationship ( QSAR ) model . The QSAR model calculates the proper composition of the polymer-carbon black matrix...example, the BEI Gyrochip Model QRS11 from Systron Donner Inertial Division has a startup time of less than 1 second, a Mean Time Between Failure (MTBF... modeling from many equations per atom to a few lines of code. This approach is amenable to parallel processing. Nevertheless, their programs require

Improved Sensitivity and Specificity for Detection of Prostate Cancer

DTIC Science & Technology

2007-11-01

potential energy of the system at static equilibrium is purely the strain energy U, as defined in the following expression ( Ugural and Fenster...xzyzxyzyx )( 2 1 )( 222222 γγγεεεµ (2) Based on the strain–displacement relationship ( Ugural and Fenster, 1995), this equation can be rewritten in terms of...Classical Dynamics, Dover, Mineola, NY: Dover Publications, 1997. [22] Ugural AC, Fenster SK: Advanced Strength and Applied Elasticity, 3 rd ed

Structure-activity relationships in beta-defensin peptides.

PubMed

Taylor, Karen; Barran, Perdita E; Dorin, Julia R

2008-01-01

The beta-defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties. (c) 2007 Wiley Periodicals, Inc.

Using a Drama-Based Education Programme to Develop a "Relational" Approach to Care for Those Working with People Living with Dementia

ERIC Educational Resources Information Center

Greenwood, Dennis

2015-01-01

The argument explored in this paper is that a "system" approach to care can have a potentially detrimental effect on, what is assumed here to be, the most important aspect of providing care and that is the relationship between the person that provides care and the person with dementia who is in receipt of care. A contrast between the…

System and method for generating a relationship network

DOEpatents

Franks, Kasian; Myers, Cornelia A; Podowski, Raf M

2015-05-05

A computer-implemented system and process for generating a relationship network is disclosed. The system provides a set of data items to be related and generates variable length data vectors to represent the relationships between the terms within each data item. The system can be used to generate a relationship network for documents, images, or any other type of file. This relationship network can then be queried to discover the relationships between terms within the set of data items.

System and method for generating a relationship network

DOEpatents

Franks, Kasian [Kensington, CA; Myers, Cornelia A [St. Louis, MO; Podowski, Raf M [Pleasant Hill, CA

2011-07-26

A computer-implemented system and process for generating a relationship network is disclosed. The system provides a set of data items to be related and generates variable length data vectors to represent the relationships between the terms within each data item. The system can be used to generate a relationship network for documents, images, or any other type of file. This relationship network can then be queried to discover the relationships between terms within the set of data items.

Remote systems development

NASA Technical Reports Server (NTRS)

Olsen, R.; Schaefer, O.; Hussey, J.

1992-01-01

Potential space missions of the nineties and the next century require that we look at the broad category of remote systems as an important means to achieve cost-effective operations, exploration and colonization objectives. This paper addresses such missions, which can use remote systems technology as the basis for identifying required capabilities which must be provided. The relationship of the space-based tasks to similar tasks required for terrestrial applications is discussed. The development status of the required technology is assessed and major issues which must be addressed to meet future requirements are identified. This includes the proper mix of humans and machines, from pure teleoperation to full autonomy; the degree of worksite compatibility for a robotic system; and the required design parameters, such as degrees-of-freedom. Methods for resolution are discussed including analysis, graphical simulation and the use of laboratory test beds. Grumman experience in the application of these techniques to a variety of design issues are presented utilizing the Telerobotics Development Laboratory which includes a 17-DOF robot system, a variety of sensing elements, Deneb/IRIS graphics workstations and control stations. The use of task/worksite mockups, remote system development test beds and graphical analysis are discussed with examples of typical results such as estimates of task times, task feasibility and resulting recommendations for design changes. The relationship of this experience and lessons-learned to future development of remote systems is also discussed.

Aedes ægypti control in urban areas: A systemic approach to a complex dynamic.

PubMed

Carvalho, Marilia Sá; Honorio, Nildimar Alves; Garcia, Leandro Martin Totaro; Carvalho, Luiz Carlos de Sá

2017-07-01

The available strategy for controlling the diseases transmitted by Aedes ægypti (dengue fever, Zika, and chikungunya) relies on continued community participation. Despite slogans emphasizing how easy it should be, no country has achieved it since the seventies. To better investigate potentially sustainable interventions, we developed a systemic model based on a multidisciplinary approach, integrating as deeply as possible specialized knowledge and field experience. The resulting model is composed of 4 external and 8 internal subsystems and 31 relationships, consistent with the literature and checked over multiple iterations with specialists of the many areas. We analyzed the model and the main feedback loops responsible for the system's stability, searching for possible interventions that could shift the existing balance. We suggest the introduction of 1 more player, the local primary health care structure, with the potential to change the undesired equilibrium. The health agents in the areas are the first to detect disease cases, and they could stimulate individuals to inform about potential mosquitoes' breeding sites and bring timely information to the vector-control program. Triggering such an action could introduce changes in people's attitude through a positive feedback loop in the desired direction.

The Impact of Teen Court on Rural Adolescents: Improved Social Relationships, Psychological Functioning, and School Experiences.

PubMed

Smokowski, Paul R; Rose, Roderick A; Evans, Caroline B R; Barbee, James; Cotter, Katie L; Bower, Meredith

2017-08-01

Teen Court is a prevention program aimed at diverting first time juvenile offenders from the traditional juvenile justice system and reintegrating them into the community. Few studies have examined if Teen Court impacts adolescent functioning. We examined how Teen Court participation impacted psychosocial functioning, social relationships, and school experiences in a sample of 392 rural Teen Court participants relative to two comparison samples, one from the same county as Teen Court (n = 4276) and one from a neighboring county (n = 3584). We found that Teen Court has the potential to decrease internalizing symptoms, externalizing behavior, violent behavior, parent-adolescent conflict, and delinquent friends, and increase self-esteem and school satisfaction.

Systemic change increases forecast uncertainty of land use change models

NASA Astrophysics Data System (ADS)

Verstegen, J. A.; Karssenberg, D.; van der Hilst, F.; Faaij, A.

2013-12-01

Cellular Automaton (CA) models of land use change are based on the assumption that the relationship between land use change and its explanatory processes is stationary. This means that model structure and parameterization are usually kept constant over time, ignoring potential systemic changes in this relationship resulting from societal changes, thereby overlooking a source of uncertainty. Evaluation of the stationarity of the relationship between land use and a set of spatial attributes has been done by others (e.g., Bakker and Veldkamp, 2012). These studies, however, use logistic regression, separate from the land use change model. Therefore, they do not gain information on how to implement the spatial attributes into the model. In addition, they often compare observations for only two points in time and do not check whether the change is statistically significant. To overcome these restrictions, we assimilate a time series of observations of real land use into a land use change CA (Verstegen et al., 2012), using a Bayesian data assimilation technique, the particle filter. The particle filter was used to update the prior knowledge about the parameterization and model structure, i.e. the selection and relative importance of the drivers of location of land use change. In a case study of sugar cane expansion in Brazil, optimal model structure and parameterization were determined for each point in time for which observations were available (all years from 2004 to 2012). A systemic change, i.e. a statistically significant deviation in model structure, was detected for the period 2006 to 2008. In this period the influence on the location of sugar cane expansion of the driver sugar cane in the neighborhood doubled, while the influence of slope and potential yield decreased by 75% and 25% respectively. Allowing these systemic changes to occur in our CA in the future (up to 2022) resulted in an increase in model forecast uncertainty by a factor two compared to the assumption of a stationary system. This means that the assumption of a constant model structure is not adequate and largely underestimates uncertainty in the forecast. Non-stationarity in land use change projections is challenging to model, because it is difficult to determine when the system will change and how. We believe that, in sight of these findings, land use change modelers should be more aware, and communicate more clearly, that what they try to project is at the limits, and perhaps beyond the limits, of what is still projectable. References Bakker, M., Veldkamp, A., 2012. Changing relationships between land use and environmental characteristics and their consequences for spatially explicit land-use change prediction. Journal of Land Use Science 7, 407-424. Verstegen, J.A., Karssenberg, D., van der Hilst, F., Faaij, A.P.C., 2012. Spatio-Temporal Uncertainty in Spatial Decision Support Systems: a Case Study of Changing Land Availability for Bioenergy Crops in Mozambique. Computers , Environment and Urban Systems 36, 30-42.

Neural mechanisms tracking popularity in real-world social networks

PubMed Central

Zerubavel, Noam; Bearman, Peter S.; Weber, Jochen; Ochsner, Kevin N.

2015-01-01

Differences in popularity are a key aspect of status in virtually all human groups and shape social interactions within them. Little is known, however, about how we track and neurally represent others’ popularity. We addressed this question in two real-world social networks using sociometric methods to quantify popularity. Each group member (perceiver) viewed faces of every other group member (target) while whole-brain functional MRI data were collected. Independent functional localizer tasks were used to identify brain systems supporting affective valuation (ventromedial prefrontal cortex, ventral striatum, amygdala) and social cognition (dorsomedial prefrontal cortex, precuneus, temporoparietal junction), respectively. During the face-viewing task, activity in both types of neural systems tracked targets’ sociometric popularity, even when controlling for potential confounds. The target popularity–social cognition system relationship was mediated by valuation system activity, suggesting that observing popular individuals elicits value signals that facilitate understanding their mental states. The target popularity–valuation system relationship was strongest for popular perceivers, suggesting enhanced sensitivity to differences among other group members’ popularity. Popular group members also demonstrated greater interpersonal sensitivity by more accurately predicting how their own personalities were perceived by other individuals in the social network. These data offer insights into the mechanisms by which status guides social behavior. PMID:26598684

Correlates of genetic monogamy in socially monogamous mammals: insights from Azara's owl monkeys

PubMed Central

Huck, Maren; Fernandez-Duque, Eduardo; Babb, Paul; Schurr, Theodore

2014-01-01

Understanding the evolution of mating systems, a central topic in evolutionary biology for more than 50 years, requires examining the genetic consequences of mating and the relationships between social systems and mating systems. Among pair-living mammals, where genetic monogamy is extremely rare, the extent of extra-group paternity rates has been associated with male participation in infant care, strength of the pair bond and length of the breeding season. This study evaluated the relationship between two of those factors and the genetic mating system of socially monogamous mammals, testing predictions that male care and strength of pair bond would be negatively correlated with rates of extra-pair paternity (EPP). Autosomal microsatellite analyses provide evidence for genetic monogamy in a pair-living primate with bi-parental care, the Azara's owl monkey (Aotus azarae). A phylogenetically corrected generalized least square analysis was used to relate male care and strength of the pair bond to their genetic mating system (i.e. proportions of EPP) in 15 socially monogamous mammalian species. The intensity of male care was correlated with EPP rates in mammals, while strength of pair bond failed to reach statistical significance. Our analyses show that, once social monogamy has evolved, paternal care, and potentially also close bonds, may facilitate the evolution of genetic monogamy. PMID:24648230

Correlates of genetic monogamy in socially monogamous mammals: insights from Azara's owl monkeys.

PubMed

Huck, Maren; Fernandez-Duque, Eduardo; Babb, Paul; Schurr, Theodore

2014-05-07

Understanding the evolution of mating systems, a central topic in evolutionary biology for more than 50 years, requires examining the genetic consequences of mating and the relationships between social systems and mating systems. Among pair-living mammals, where genetic monogamy is extremely rare, the extent of extra-group paternity rates has been associated with male participation in infant care, strength of the pair bond and length of the breeding season. This study evaluated the relationship between two of those factors and the genetic mating system of socially monogamous mammals, testing predictions that male care and strength of pair bond would be negatively correlated with rates of extra-pair paternity (EPP). Autosomal microsatellite analyses provide evidence for genetic monogamy in a pair-living primate with bi-parental care, the Azara's owl monkey (Aotus azarae). A phylogenetically corrected generalized least square analysis was used to relate male care and strength of the pair bond to their genetic mating system (i.e. proportions of EPP) in 15 socially monogamous mammalian species. The intensity of male care was correlated with EPP rates in mammals, while strength of pair bond failed to reach statistical significance. Our analyses show that, once social monogamy has evolved, paternal care, and potentially also close bonds, may facilitate the evolution of genetic monogamy.

Forecasting disease risk for increased epidemic preparedness in public health

NASA Technical Reports Server (NTRS)

Myers, M. F.; Rogers, D. J.; Cox, J.; Flahault, A.; Hay, S. I.

2000-01-01

Emerging infectious diseases pose a growing threat to human populations. Many of the world's epidemic diseases (particularly those transmitted by intermediate hosts) are known to be highly sensitive to long-term changes in climate and short-term fluctuations in the weather. The application of environmental data to the study of disease offers the capability to demonstrate vector-environment relationships and potentially forecast the risk of disease outbreaks or epidemics. Accurate disease forecasting models would markedly improve epidemic prevention and control capabilities. This chapter examines the potential for epidemic forecasting and discusses the issues associated with the development of global networks for surveillance and prediction. Existing global systems for epidemic preparedness focus on disease surveillance using either expert knowledge or statistical modelling of disease activity and thresholds to identify times and areas of risk. Predictive health information systems would use monitored environmental variables, linked to a disease system, to be observed and provide prior information of outbreaks. The components and varieties of forecasting systems are discussed with selected examples, along with issues relating to further development.

Active living and biking: tracing the evolution of a biking system in Arlington, Virginia.

PubMed

Hanson, Royce; Young, Garry

2008-06-01

In Arlington, Virginia, a steady evolutionary change in biking policy during the last three decades has yielded some of the nation's best biking assets. It has a comprehensive, well-connected, highly integrated, well-mapped, and well-signed system of shared-use paved trails, bike lanes, bike routes, and other biking assets, such as workplace showers. Understanding the conditions that led to Arlington's current biking system can provide lessons in the strategy and tactics of active-living politics. One potentially effective political strategy that was successful in Arlington is for activists to pressure elected officials to select professional managers who see bike-ways as crucial to the overall transportation system. Then it is important to formalize the government-citizen relationship through an advisory panel. Also, in Arlington, the incremental creation of biking assets helped create demand for more and better facilities. In turn, this created political support for expanding and upgrading. Finally, Arlington used potentially negative circumstances (e.g., the building of highway corridors, the introduction of the Metro) as opportunities to change the built environment in ways that have encouraged more active living.

Forecasting Disease Risk for Increased Epidemic Preparedness in Public Health

PubMed Central

Myers, M.F.; Rogers, D.J.; Cox, J.; Flahault, A.; Hay, S.I.

2011-01-01

Emerging infectious diseases pose a growing threat to human populations. Many of the world’s epidemic diseases (particularly those transmitted by intermediate hosts) are known to be highly sensitive to long-term changes in climate and short-term fluctuations in the weather. The application of environmental data to the study of disease offers the capability to demonstrate vector–environment relationships and potentially forecast the risk of disease outbreaks or epidemics. Accurate disease forecasting models would markedly improve epidemic prevention and control capabilities. This chapter examines the potential for epidemic forecasting and discusses the issues associated with the development of global networks for surveillance and prediction. Existing global systems for epidemic preparedness focus on disease surveillance using either expert knowledge or statistical modelling of disease activity and thresholds to identify times and areas of risk. Predictive health information systems would use monitored environmental variables, linked to a disease system, to be observed and provide prior information of outbreaks. The components and varieties of forecasting systems are discussed with selected examples, along with issues relating to further development. PMID:10997211

Combined heat and power systems for commercial buildings: investigating cost, emissions, and primary energy reduction based on system components

NASA Astrophysics Data System (ADS)

Smith, Amanda D.

Combined heat and power (CHP) systems produce electricity and useful heat from fuel. When power is produced near a building which consumes power, transmission losses are averted, and heat which is a byproduct of power production may be useful to the building. That thermal energy can be used for hot water or space heating, among other applications. This dissertation focuses on CHP systems using natural gas, a common fuel, and systems serving commercial buildings in the United States. First, the necessary price difference between purchased electricity and purchased fuel is analyzed in terms of the efficiencies of system components by comparing CHP with a conventional separate heat and power (SHP) configuration, where power is purchased from the electrical grid and heat is provided by a gas boiler. Similarly, the relationship between CDE due to electricity purchases and due to fuel purchases is analyzed as well as the relationship between primary energy conversion factors for electricity and fuel. The primary energy conversion factor indicates the quantity of source energy necessary to produce the energy purchased at the site. Next, greenhouse gas emissions are investigated for a variety of commercial buildings using CHP or SHP. The relationship between the magnitude of the reduction in emissions and the parameters of the CHP system is explored. The cost savings and reduction in primary energy consumption are evaluated for the same buildings. Finally, a CHP system is analyzed with the addition of a thermal energy storage (TES) component, which can store excess thermal energy and deliver it later if necessary. The potential for CHP with TES to reduce cost, emissions, and primary energy consumption is investigated for a variety of buildings. A case study is developed for one building for which TES does provide additional benefits over a CHP system alone, and the requirements for a water tank TES device are examined.

Development of magnitude scaling relationship for earthquake early warning system in South Korea

NASA Astrophysics Data System (ADS)

Sheen, D.

2011-12-01

Seismicity in South Korea is low and magnitudes of recent earthquakes are mostly less than 4.0. However, historical earthquakes of South Korea reveal that many damaging earthquakes had occurred in the Korean Peninsula. To mitigate potential seismic hazard in the Korean Peninsula, earthquake early warning (EEW) system is being installed and will be operated in South Korea in the near future. In order to deliver early warnings successfully, it is very important to develop stable magnitude scaling relationships. In this study, two empirical magnitude relationships are developed from 350 events ranging in magnitude from 2.0 to 5.0 recorded by the KMA and the KIGAM. 1606 vertical component seismograms whose epicentral distances are within 100 km are chosen. The peak amplitude and the maximum predominant period of the initial P wave are used for finding magnitude relationships. The peak displacement of seismogram recorded at a broadband seismometer shows less scatter than the peak velocity of that. The scatters of the peak displacement and the peak velocity of accelerogram are similar to each other. The peak displacement of seismogram differs from that of accelerogram, which means that two different magnitude relationships for each type of data should be developed. The maximum predominant period of the initial P wave is estimated after using two low-pass filters, 3 Hz and 10 Hz, and 10 Hz low-pass filter yields better estimate than 3 Hz. It is found that most of the peak amplitude and the maximum predominant period are estimated within 1 sec after triggering.

Association between perceived insufficient sleep, frequent mental distress, obesity and chronic diseases among US adults, 2009 behavioral risk factor surveillance system.

PubMed

Liu, Yong; Croft, Janet B; Wheaton, Anne G; Perry, Geraldine S; Chapman, Daniel P; Strine, Tara W; McKnight-Eily, Lela R; Presley-Cantrell, Letitia

2013-01-29

Although evidence suggests that poor sleep is associated with chronic disease, little research has been conducted to assess the relationships between insufficient sleep, frequent mental distress (FMD ≥14 days during the past 30 days), obesity, and chronic disease including diabetes mellitus, coronary heart disease, stroke, high blood pressure, asthma, and arthritis. Data from 375,653 US adults aged ≥ 18 years in the 2009 Behavioral Risk Factor Surveillance System were used to assess the relationships between insufficient sleep and chronic disease. The relationships were further examined using a multivariate logistic regression model after controlling for age, sex, race/ethnicity, education, and potential mediators (FMD and obesity). The overall prevalence of insufficient sleep during the past 30 days was 10.4% for all 30 days, 17.0% for 14-29 days, 42.0% for 1-13 days, and 30.6% for zero day. The positive relationships between insufficient sleep and each of the six chronic disease were significant (p < 0.0001) after adjustment for covariates and were modestly attenuated but not fully explained by FMD. The relationships between insufficient sleep and both diabetes and high blood pressure were also modestly attenuated but not fully explained by obesity. Assessment of sleep quantity and quality and additional efforts to encourage optimal sleep and sleep health should be considered in routine medical examinations. Ongoing research designed to test treatments for obesity, mental distress, or various chronic diseases should also consider assessing the impact of these treatments on sleep health.

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden.

PubMed

Rainey-Smith, Stephanie R; Mazzucchelli, Gavin N; Villemagne, Victor L; Brown, Belinda M; Porter, Tenielle; Weinborn, Michael; Bucks, Romola S; Milicic, Lidija; Sohrabi, Hamid R; Taddei, Kevin; Ames, David; Maruff, Paul; Masters, Colin L; Rowe, Christopher C; Salvado, Olivier; Martins, Ralph N; Laws, Simon M

2018-02-26

The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid deposition, suggesting that Aquaporin-4 plays a pivotal role in glymphatic function. Currently there is a paucity of literature regarding the impact of AQP4 genetic variation on sleep, brain Aβ-amyloid burden and their relationship to each other in humans. To address this a cross-sectional observational study was undertaken in cognitively normal older adults from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Genetic variants in AQP4 were investigated with respect to self-reported Pittsburgh Sleep Quality Index sleep parameters, positron emission tomography derived brain Aβ-amyloid burden and whether these genetic variants moderated the sleep-Aβ-amyloid burden relationship. One AQP4 variant, rs72878776, was associated with poorer overall sleep quality, while several SNPs moderated the effect of sleep latency (rs491148, rs9951307, rs7135406, rs3875089, rs151246) and duration (rs72878776, rs491148 and rs2339214) on brain Aβ-amyloid burden. This study suggests that AQP4 genetic variation moderates the relationship between sleep and brain Aβ-amyloid burden, which adds weight to the proposed glymphatic system being a potential Aβ-amyloid clearance mechanism and suggests that AQP4 genetic variation may impair this function. Further, AQP4 genetic variation should be considered when interpreting sleep-Aβ relationships.

From the surface to the deep critical zone: Linking soil carbon, fluid saturation and weathering rate

NASA Astrophysics Data System (ADS)

Druhan, Jennifer; Lawrence, Corey; Oster, Jessica; Rempe, Daniella; Dietrich, William

2017-04-01

Shallow soils from a wide range of ecosystems demonstrate a clear and consistent relationship between effective fluid saturation and the rate at which organic carbon is converted to CO2. While the underlying mechanisms contributing to this dependence are diverse, a consistent pattern of maximum CO2 production at intermediate soil moisture supports a generalized functional relationship, which may be incorporated into a quantitative reactive transport framework. A key result of this model development is a prediction of the extent to which the inorganic carbon content of water in biologically active soils varies as a function of hydrologic parameters (i.e. moisture content and residence time), and in turn influences weathering reactions. Deeper in the CZ, the consistency of this relationship and the influence of hydrologically - regulated CO2 production on the rates of water - rock interaction are largely unknown. Here, we use a novel reactive transport model incorporating this functional relationship to consider how variations in the reactive potential of water entering the vadose zone influences subsurface weathering rates. We leverage two examples of variably saturated natural systems to consider (1) CO2 production and associated weathering potential regulated by seasonal hydrologic shifts and (2) the preservation of soil carbon signatures in the deep CZ over millennial timescales. First, at the Eel River CZ Observatory in Northern California, USA, a novel Vadose Zone Monitoring System (VMS) installed in a 14 - 20 m thick unsaturated section offers an unprecedented view into the physical, chemical and biological behavior of the depth profile separating soils from groundwater. Based on soil moisture, gas and fluid phase samples, we demonstrate a predictive relationship between seasonal hydrologic variations and the location and magnitude of geochemical weathering rates. Second, an environmental monitoring project in the Blue Springs Cave, Sparta, TN, USA, provides chemical and isotopic signatures of both soil and cave drip water, allowing constraint of a model for the evolution of fluid with depth through a karst system. The carbon isotope signatures of these speleothems have been suggested as a record of long term variations in CZ vegetation, soil respiration and carbon stability. Using our modeling approach, we offer a prediction of the extent to which hydrologically - driven variations in carbon respiration are converted to weathering rates in karst systems and ultimately preserved within the speleothem record. By combining this novel modeling approach with these two examples, we illustrate a quantitative framework for (1) the influence of hydro-biological coupling in shallow soils on deep weathering regimes in the Critical Zone, and (2) the preservation of these signals in the geologic record.

The ecology of microorganisms in a small closed system: Potential benefits and problems for space station

NASA Technical Reports Server (NTRS)

Rodgers, E. B.

1986-01-01

The inevitble presence on the space station of microorganisms associated with crew members and their environment will have the potential for both benefits and a range of problems including illness and corrosion of materials. This report reviews the literature presenting information about microorganisms pertinent to Environmental Control and Life Support (ECLS) on the space station. The perspective of the report is ecological, viewing the space station as an ecosystem in which biological relationships are affected by factors such as zero gravity and by closure of a small volume of space. Potential sites and activities of microorganisms on the space station and their environmental limits, microbial standards for the space station, monitoring and control methods, effects of space factors on microorganisms, and extraterrestrial contamination are discussed.

Epithelial Ovarian Cancer Metastatic to the Central Nervous System and a Family History Concerning for Hereditary Breast and Ovarian Cancer--A Potential Relationship.

PubMed

Jernigan, Amelia M; Mahdi, Haider; Rose, Peter G

2015-09-01

To estimate the frequency of hereditary breast and ovarian cancer (HBOC) in women with central nervous system (CNS) metastasis from epithelial ovarian cancer (EOC) and to evaluate for a potential relationship between HBOC status and survival. A total of 1240 cases of EOC treated between 1995 and 2014 were reviewed to identify CNS metastasis. Demographics, treatment, family history, genetic testing, and survival outcomes were recorded. Women were then classified as HBOC+ or HBOC- based on histories and genetic testing results. Kaplan-Meier survival curves and univariable Cox proportional hazards models were used. Of 1240 cases, 32 cases of EOC with CNS metastasis were identified (2.58%). Median age was 52.13 (95% confidence interval [CI], 40.56-78.38) years, and 87.10% had stage III to IV disease. Among those with documented personal and family history, 66.7% (20/30) were suspicious for HBOC syndrome. Among those who underwent germline testing, 71.43% (5/7) had a pathogenic BRCA mutation. The median time from diagnosis to CNS metastasis was 29.17 (95% CI, 0-187.91) months. At a median survival of 5.97 (95% CI, 0.20-116.95) months from the time of CNS metastasis and 43.76 (95% CI, 1.54-188.44) months from the time of EOC diagnosis, 29 women died of disease. Univariate Cox proportional hazard models were used to compare HBOC- to HBOC+ women and did not reveal a significant difference for survival outcomes. Confirmed BRCA mutations and histories concerning for HBOC syndrome are common in women with EOC metastatic to the CNS. We did not demonstrate a relationship between HBOC status and survival outcomes, but were not powered to do so.

Simultaneous Global Positioning System observations of equatorial scintillations and total electron content fluctuations

NASA Astrophysics Data System (ADS)

Beach, Theodore L.; Kintner, Paul M.

1999-10-01

One aspect of the Global Positioning System (GPS) is the potential to conduct geophysical research, and worldwide networks of GPS receivers have been established to exploit this potential. Several research groups have begun using this global GPS data to study ionospheric total electron content (TEC) variations, also referred to as GPS phase fluctuations, as surrogates for ionospheric scintillations. This paper investigates the relationship between GPS amplitude scintillations and TEC variations for the same line of sight using observations from Ancón, Peru. These observations were taken under equatorial spread F conditions for three nights in April 1997. As expected, only when the spectrum of TEC fluctuations includes significant power at the Fresnel scale do scintillations appear. We also find that when the TEC fluctuation spectrum includes the Fresnel scale, the S4 scintillation index is roughly proportional to measures of TEC fluctuation for the weak scintillations observed. The proportionality constant varies from night to night, however, casting doubt on the ability to predict GPS S4 successfully from TEC fluctuation data alone. We also present a simple theoretical phase screen model and show that if a relationship between TEC fluctuation measures and S4 exists, that relationship depends on the power spectrum of phase variations at the screen. Unfortunately, the available TEC data, at 30 s per sample (with some aliasing apparently permitted), offer limited spectral information. A preliminary comparison of 1 s/sample data with the same data decimated to a 30 s/sample interval suggests, however, that the level of successful S4 prediction, based on TEC fluctuation measures alone, is comparable at either sample rate.

Reading biological processes from nucleotide sequences

NASA Astrophysics Data System (ADS)

Murugan, Anand

Cellular processes have traditionally been investigated by techniques of imaging and biochemical analysis of the molecules involved. The recent rapid progress in our ability to manipulate and read nucleic acid sequences gives us direct access to the genetic information that directs and constrains biological processes. While sequence data is being used widely to investigate genotype-phenotype relationships and population structure, here we use sequencing to understand biophysical mechanisms. We present work on two different systems. First, in chapter 2, we characterize the stochastic genetic editing mechanism that produces diverse T-cell receptors in the human immune system. We do this by inferring statistical distributions of the underlying biochemical events that generate T-cell receptor coding sequences from the statistics of the observed sequences. This inferred model quantitatively describes the potential repertoire of T-cell receptors that can be produced by an individual, providing insight into its potential diversity and the probability of generation of any specific T-cell receptor. Then in chapter 3, we present work on understanding the functioning of regulatory DNA sequences in both prokaryotes and eukaryotes. Here we use experiments that measure the transcriptional activity of large libraries of mutagenized promoters and enhancers and infer models of the sequence-function relationship from this data. For the bacterial promoter, we infer a physically motivated 'thermodynamic' model of the interaction of DNA-binding proteins and RNA polymerase determining the transcription rate of the downstream gene. For the eukaryotic enhancers, we infer heuristic models of the sequence-function relationship and use these models to find synthetic enhancer sequences that optimize inducibility of expression. Both projects demonstrate the utility of sequence information in conjunction with sophisticated statistical inference techniques for dissecting underlying biophysical mechanisms.

Detecting early warning signals of tree mortality in boreal North America using multiscale satellite data.

PubMed

Rogers, Brendan M; Solvik, Kylen; Hogg, Edward H; Ju, Junchang; Masek, Jeffrey G; Michaelian, Michael; Berner, Logan T; Goetz, Scott J

2018-06-01

Increasing tree mortality from global change drivers such as drought and biotic infestations is a widespread phenomenon, including in the boreal zone where climate changes and feedbacks to the Earth system are relatively large. Despite the importance for science and management communities, our ability to forecast tree mortality at landscape to continental scales is limited. However, two independent information streams have the potential to inform and improve mortality forecasts: repeat forest inventories and satellite remote sensing. Time series of tree-level growth patterns indicate that productivity declines and related temporal dynamics often precede mortality years to decades before death. Plot-level productivity, in turn, has been related to satellite-based indices such as the Normalized difference vegetation index (NDVI). Here we link these two data sources to show that early warning signals of mortality are evident in several NDVI-based metrics up to 24 years before death. We focus on two repeat forest inventories and three NDVI products across western boreal North America where productivity and mortality dynamics are influenced by periodic drought. These data sources capture a range of forest conditions and spatial resolution to highlight the sensitivity and limitations of our approach. Overall, results indicate potential to use satellite NDVI for early warning signals of mortality. Relationships are broadly consistent across inventories, species, and spatial resolutions, although the utility of coarse-scale imagery in the heterogeneous aspen parkland was limited. Longer-term NDVI data and annually remeasured sites with high mortality levels generate the strongest signals, although we still found robust relationships at sites remeasured at a typical 5 year frequency. The approach and relationships developed here can be used as a basis for improving forest mortality models and monitoring systems. © 2018 John Wiley & Sons Ltd.

A usability evaluation of four commercial dental computer-based patient record systems

PubMed Central

Thyvalikakath, Thankam P.; Monaco, Valerie; Thambuganipalle, Hima Bindu; Schleyer, Titus

2008-01-01

Background The usability of dental computer-based patient record (CPR) systems has not been studied, despite early evidence that poor usability is a problem for dental CPR system users at multiple levels. Methods The authors conducted formal usability tests of four dental CPR systems by using a purposive sample of four groups of five novice users. The authors measured task outcomes (correctly completed, incorrectly completed and incomplete) in each CPR system while the participants performed nine clinical documentation tasks, as well as the number of usability problems identified in each CPR system and their potential relationship to task outcomes. The authors reviewed the software application design aspects responsible for these usability problems. Results The range for correctly completed tasks was 16 to 64 percent, for incorrectly completed tasks 18 to 38 percent and for incomplete tasks 9 to 47 percent. The authors identified 286 usability problems. The main types were three unsuccessful attempts, negative affect and task incorrectly completed. They also identified six problematic interface and interaction designs that led to usability problems. Conclusion The four dental CPR systems studied have significant usability problems for novice users, resulting in a steep learning curve and potentially reduced system adoption. Clinical Implications The significant number of data entry errors raises concerns about the quality of documentation in clinical practice. PMID:19047669

Is There Consistency between the Binding Affinity and Inhibitory Potential of Natural Polyphenols as α-amylase Inhibitors?

PubMed

Xu, Wei; Shao, Rong; Xiao, Jianbo

2016-07-26

The inhibitory potential of natural polyphenols for α-amylases has attracted great interests among researchers. The structure-affinity properties of natural polyphenols binding to α-amylase and the structure-activity relationship of dietary polyphenols inhibiting α-amylase were deeply investigated. There is a lack of consistency between the structure-affinity relationship and the structure-activity relationship of natural polyphenols as α-amylase inhibitors. Is it consistent between the binding affinity and inhibitory potential of natural polyphenols as with α-amylase inhibitors? It was found that the consistency between the binding affinity and inhibitory potential of natural polyphenols as with α-amylase inhibitors is not equivocal. For example, there is no consistency between the binding affinity and the inhibitory potential of quercetin and its glycosides as α-amylase inhibitors. However, catechins with higher α-amylase inhibitory potential exhibited higher affinity with α-amylase.

Sequence-Dependent Structure/Function Relationships of Catalytic Peptide-Enabled Gold Nanoparticles Generated under Ambient Synthetic Conditions.

PubMed

Bedford, Nicholas M; Hughes, Zak E; Tang, Zhenghua; Li, Yue; Briggs, Beverly D; Ren, Yang; Swihart, Mark T; Petkov, Valeri G; Naik, Rajesh R; Knecht, Marc R; Walsh, Tiffany R

2016-01-20

Peptide-enabled nanoparticle (NP) synthesis routes can create and/or assemble functional nanomaterials under environmentally friendly conditions, with properties dictated by complex interactions at the biotic/abiotic interface. Manipulation of this interface through sequence modification can provide the capability for material properties to be tailored to create enhanced materials for energy, catalysis, and sensing applications. Fully realizing the potential of these materials requires a comprehensive understanding of sequence-dependent structure/function relationships that is presently lacking. In this work, the atomic-scale structures of a series of peptide-capped Au NPs are determined using a combination of atomic pair distribution function analysis of high-energy X-ray diffraction data and advanced molecular dynamics (MD) simulations. The Au NPs produced with different peptide sequences exhibit varying degrees of catalytic activity for the exemplar reaction 4-nitrophenol reduction. The experimentally derived atomic-scale NP configurations reveal sequence-dependent differences in structural order at the NP surface. Replica exchange with solute-tempering MD simulations are then used to predict the morphology of the peptide overlayer on these Au NPs and identify factors determining the structure/catalytic properties relationship. We show that the amount of exposed Au surface, the underlying surface structural disorder, and the interaction strength of the peptide with the Au surface all influence catalytic performance. A simplified computational prediction of catalytic performance is developed that can potentially serve as a screening tool for future studies. Our approach provides a platform for broadening the analysis of catalytic peptide-enabled metallic NP systems, potentially allowing for the development of rational design rules for property enhancement.

The shaping of pharmaceutical governance: the Israeli case.

PubMed

Sax, Philip

2014-01-01

This article focuses on governance of the pharmaceutical sector in Israel. It traces the relationships between the state, industry, and sick funds from before the establishment of National Health Insurance (NHI) in 1995 to the beginning of this decade, in particular as they have grappled with the challenge of making national formulary decisions in a rational manner. Subsequent to the introduction of NHI there have been shifts in the modes and mix of governance. This research shows empirically that a relatively complex mix of hierarchical and network modes of governance can be successfully established over an extended period of time when flexibility is maintained through the implementation process. The system for defining and updating a standard basket of health services has coped well with the challenge of managing a range of difficult and potentially volatile stakeholder relationships in the pharmaceutical sector and of distancing ministers from controversies of funding and listing decisions. Government has succeeded in containing drug costs whilst still maintaining a basket of reimbursable drugs that, from an international perspective, is comprehensive and technologically advanced. On the other hand, network arrangements appear to have delayed the introduction of suitable accountability relationships and hindered their development. The state has traditionally played an intermediary role between unavoidable corporate interests of industry and sick funds, with little transparency and to the detriment of more pluralistic access to decision making. Governance arrangements in Israel appear to limit the potential and incentive of the state and the sick funds to realize their potential countervailing powers in subsidy and pricing decisions.

The shaping of pharmaceutical governance: the Israeli case

PubMed Central

2014-01-01

This article focuses on governance of the pharmaceutical sector in Israel. It traces the relationships between the state, industry, and sick funds from before the establishment of National Health Insurance (NHI) in 1995 to the beginning of this decade, in particular as they have grappled with the challenge of making national formulary decisions in a rational manner. Subsequent to the introduction of NHI there have been shifts in the modes and mix of governance. This research shows empirically that a relatively complex mix of hierarchical and network modes of governance can be successfully established over an extended period of time when flexibility is maintained through the implementation process. The system for defining and updating a standard basket of health services has coped well with the challenge of managing a range of difficult and potentially volatile stakeholder relationships in the pharmaceutical sector and of distancing ministers from controversies of funding and listing decisions. Government has succeeded in containing drug costs whilst still maintaining a basket of reimbursable drugs that, from an international perspective, is comprehensive and technologically advanced. On the other hand, network arrangements appear to have delayed the introduction of suitable accountability relationships and hindered their development. The state has traditionally played an intermediary role between unavoidable corporate interests of industry and sick funds, with little transparency and to the detriment of more pluralistic access to decision making. Governance arrangements in Israel appear to limit the potential and incentive of the state and the sick funds to realize their potential countervailing powers in subsidy and pricing decisions. PMID:24914409

Modeling the effect of social networks on adoption of multifunctional agriculture.

PubMed

Manson, Steven M; Jordan, Nicholas R; Nelson, Kristen C; Brummel, Rachel F

2016-01-01

Rotational grazing (RG) has attracted much attention as a cornerstone of multifunctional agriculture (MFA) in animal systems, potentially capable of producing a range of goods and services of value to diverse stakeholders in agricultural landscapes and rural communities, as well as broader societal benefits. Despite these benefits, global adoption of MFA has been uneven, with some places seeing active participation, while others have seen limited growth. Recent conceptual models of MFA emphasize the potential for bottom-up processes and linkages among social and environmental systems to promote multifunctionality. Social networks are critical to these explanations but how and why these networks matter is unclear. We investigated fifty-three farms in three states in the United States (New York, Wisconsin, Pennsylvania) and developed a stylized model of social networks and systemic change in the dairy farming system. We found that social networks are important to RG adoption but their impact is contingent on social and spatial factors. Effects of networks on farmer decision making differ according to whether they comprise weak-tie relationships, which bridge across disparate people and organizations, or strong-tie relationships, which are shared by groups in which members are well known to one another. RG adoption is also dependent on features of the social landscape including the number of dairy households, the probability of neighboring farmers sharing strong ties, and the role of space in how networks are formed. The model replicates features of real-world adoption of RG practices in the Eastern US and illustrates pathways toward greater multifunctionality in the dairy landscape. Such models are likely to be of heuristic value in network-focused strategies for agricultural development.

Modeling the effect of social networks on adoption of multifunctional agriculture

PubMed Central

Manson, Steven M.; Jordan, Nicholas R.; Nelson, Kristen C.; Brummel, Rachel F.

2014-01-01

Rotational grazing (RG) has attracted much attention as a cornerstone of multifunctional agriculture (MFA) in animal systems, potentially capable of producing a range of goods and services of value to diverse stakeholders in agricultural landscapes and rural communities, as well as broader societal benefits. Despite these benefits, global adoption of MFA has been uneven, with some places seeing active participation, while others have seen limited growth. Recent conceptual models of MFA emphasize the potential for bottom-up processes and linkages among social and environmental systems to promote multifunctionality. Social networks are critical to these explanations but how and why these networks matter is unclear. We investigated fifty-three farms in three states in the United States (New York, Wisconsin, Pennsylvania) and developed a stylized model of social networks and systemic change in the dairy farming system. We found that social networks are important to RG adoption but their impact is contingent on social and spatial factors. Effects of networks on farmer decision making differ according to whether they comprise weak-tie relationships, which bridge across disparate people and organizations, or strong-tie relationships, which are shared by groups in which members are well known to one another. RG adoption is also dependent on features of the social landscape including the number of dairy households, the probability of neighboring farmers sharing strong ties, and the role of space in how networks are formed. The model replicates features of real-world adoption of RG practices in the Eastern US and illustrates pathways toward greater multifunctionality in the dairy landscape. Such models are likely to be of heuristic value in network-focused strategies for agricultural development. PMID:26744579

Statistical properties of correlated solar flares and coronal mass ejections in cycles 23 and 24

NASA Astrophysics Data System (ADS)

Aarnio, Alicia

2018-01-01

Outstanding problems in understanding early stellar systems include mass loss, angular momentum evolution, and the effects of energetic events on the surrounding environs. The latter of these drives much research into our own system's space weather and the development of predictive algorithms for geomagnetic storms. So dually motivated, we have leveraged a big-data approach to combine two decades of GOES and LASCO data to identify a large sample of spatially and temporally correlated solar flares and CMEs. In this presentation, we revisit the analysis of Aarnio et al. (2011), adding 10 years of data and further exploring the relationships between correlated flare and CME properties. We compare the updated data set results to those previously obtained, and discuss the effects of selecting smaller time windows within solar cycles 23 and 24 on the empirically defined relationships between correlated flare and CME properties. Finally, we discuss a newly identified large sample of potentially interesting correlated flares and CMEs perhaps erroneously excluded from previous searches.

Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons.

PubMed

Medrano, Mireia; Aguinaga, David; Reyes-Resina, Irene; Canela, Enric I; Mallol, Josefa; Navarro, Gemma; Franco, Rafael

2018-06-01

The hypothalamus is a key integrator of nutrient-seeking signals in the form of hormones and metabolites originated in both the central nervous system and the periphery. The main autocrine and paracrine target of orexinergic-related hormones such as leptin, orexin/hypocretin, and ghrelin are neuropeptide Y neurons located in the arcuate nucleus of the hypothalamus. The aim of this study was to investigate the expression and the molecular and functional relationships between leptin, orexin/hypocretin and ghrelin receptors. Biophysical studies in a heterologous system showed physical interactions between them, with potential formation of heterotrimeric complexes. Functional assays showed robust allosteric interactions particularly different when the three receptors are expressed together. Further biochemical and pharmacological assays provided evidence of heterotrimer functional expression in primary cultures of hypothalamic neurons. These findings constitute evidence of close relationships in the action of the three hormones already starting at the receptor level in hypothalamic cells.

Local thermodynamic equilibrium for globally disequilibrium open systems under stress

NASA Astrophysics Data System (ADS)

Podladchikov, Yury

2016-04-01

Predictive modeling of far and near equilibrium processes is essential for understanding of patterns formation and for quantifying of natural processes that are never in global equilibrium. Methods of both equilibrium and non-equilibrium thermodynamics are needed and have to be combined. For example, predicting temperature evolution due to heat conduction requires simultaneous use of equilibrium relationship between internal energy and temperature via heat capacity (the caloric equation of state) and disequilibrium relationship between heat flux and temperature gradient. Similarly, modeling of rocks deforming under stress, reactions in system open for the porous fluid flow, or kinetic overstepping of the equilibrium reaction boundary necessarily needs both equilibrium and disequilibrium material properties measured under fundamentally different laboratory conditions. Classical irreversible thermodynamics (CIT) is the well-developed discipline providing the working recipes for the combined application of mutually exclusive experimental data such as density and chemical potential at rest under constant pressure and temperature and viscosity of the flow under stress. Several examples will be presented.

Autonomic nervous system function, child behavior, and maternal sensitivity in three-year-old children with surgically corrected transposition.

PubMed

Harrison, Tondi M

2013-01-01

Explore relationships among autonomic nervous system (ANS) function, child behavior, and maternal sensitivity in three-year-old children with surgically corrected transposition of the great arteries (TGA) and in children healthy at birth. Children surviving complex congenital heart defects are at risk for behavior problems. ANS function is associated with behavior and with maternal sensitivity. Child ANS function (heart rate variability) and maternal sensitivity (Parent-Child Early Relational Assessment) were measured during a challenging task. Mother completed the Child Behavior Checklist. Data were analyzed descriptively and graphically. Children with TGA had less responsive autonomic function and more behavior problems than healthy children. Autonomic function improved with more maternal sensitivity. Alterations in ANS function may continue years after surgical correction in children with TGA, potentially impacting behavioral regulation. Maternal sensitivity may be associated with ANS function in this population. Continued research on relationships among ANS function, child behavior, and maternal sensitivity is warranted. Copyright © 2013 Elsevier Inc. All rights reserved.

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing

PubMed Central

Farley, Toni; Kiefer, Jeff; Lee, Preston; Von Hoff, Daniel; Trent, Jeffrey M; Colbourn, Charles

2013-01-01

Breakthroughs in molecular profiling technologies are enabling a new data-intensive approach to biomedical research, with the potential to revolutionize how we study, manage, and treat complex diseases. The next great challenge for clinical applications of these innovations will be to create scalable computational solutions for intelligently linking complex biomedical patient data to clinically actionable knowledge. Traditional database management systems (DBMS) are not well suited to representing complex syntactic and semantic relationships in unstructured biomedical information, introducing barriers to realizing such solutions. We propose a scalable computational framework for addressing this need, which leverages a hypergraph-based data model and query language that may be better suited for representing complex multi-lateral, multi-scalar, and multi-dimensional relationships. We also discuss how this framework can be used to create rapid learning knowledge base systems to intelligently capture and relate complex patient data to biomedical knowledge in order to automate the recovery of clinically actionable information. PMID:22859646

Exploring the Use of Computer Simulations in Unraveling Research and Development Governance Problems

NASA Technical Reports Server (NTRS)

Balaban, Mariusz A.; Hester, Patrick T.

2012-01-01

Understanding Research and Development (R&D) enterprise relationships and processes at a governance level is not a simple task, but valuable decision-making insight and evaluation capabilities can be gained from their exploration through computer simulations. This paper discusses current Modeling and Simulation (M&S) methods, addressing their applicability to R&D enterprise governance. Specifically, the authors analyze advantages and disadvantages of the four methodologies used most often by M&S practitioners: System Dynamics (SO), Discrete Event Simulation (DES), Agent Based Modeling (ABM), and formal Analytic Methods (AM) for modeling systems at the governance level. Moreover, the paper describes nesting models using a multi-method approach. Guidance is provided to those seeking to employ modeling techniques in an R&D enterprise for the purposes of understanding enterprise governance. Further, an example is modeled and explored for potential insight. The paper concludes with recommendations regarding opportunities for concentration of future work in modeling and simulating R&D governance relationships and processes.

Network Analysis of Rodent Transcriptomes in Spaceflight

NASA Technical Reports Server (NTRS)

Ramachandran, Maya; Fogle, Homer; Costes, Sylvain

2017-01-01

Network analysis methods leverage prior knowledge of cellular systems and the statistical and conceptual relationships between analyte measurements to determine gene connectivity. Correlation and conditional metrics are used to infer a network topology and provide a systems-level context for cellular responses. Integration across multiple experimental conditions and omics domains can reveal the regulatory mechanisms that underlie gene expression. GeneLab has assembled rich multi-omic (transcriptomics, proteomics, epigenomics, and epitranscriptomics) datasets for multiple murine tissues from the Rodent Research 1 (RR-1) experiment. RR-1 assesses the impact of 37 days of spaceflight on gene expression across a variety of tissue types, such as adrenal glands, quadriceps, gastrocnemius, tibalius anterior, extensor digitorum longus, soleus, eye, and kidney. Network analysis is particularly useful for RR-1 -omics datasets because it reinforces subtle relationships that may be overlooked in isolated analyses and subdues confounding factors. Our objective is to use network analysis to determine potential target nodes for therapeutic intervention and identify similarities with existing disease models. Multiple network algorithms are used for a higher confidence consensus.

The ability to tap to a beat relates to cognitive, linguistic, and perceptual skills

PubMed Central

Tierney, Adam T.; Kraus, Nina

2013-01-01

Reading-impaired children have difficulty tapping to a beat. Here we tested whether this relationship between reading ability and synchronized tapping holds in typically-developing adolescents. We also hypothesized that tapping relates to two other abilities. First, since auditory-motor synchronization requires monitoring of the relationship between motor output and auditory input, we predicted that subjects better able to tap to the beat would perform better on attention tests. Second, since auditory-motor synchronization requires fine temporal precision within the auditory system for the extraction of a sound’s onset time, we predicted that subjects better able to tap to the beat would be less affected by backward masking, a measure of temporal precision within the auditory system. As predicted, tapping performance related to reading, attention, and backward masking. These results motivate future research investigating whether beat synchronization training can improve not only reading ability, but potentially executive function and basic auditory processing as well. PMID:23400117

Understanding the complex relationships among actors involved in the implementation of public-private mix (PPM) for TB control in India, using social theory.

PubMed

Salve, Solomon; Harris, Kristine; Sheikh, Kabir; Porter, John D H

2018-06-07

Public Private Partnerships (PPP) are increasingly utilized as a public health strategy for strengthening health systems and have become a core component for the delivery of TB control services in India, as promoted through national policy. However, partnerships are complex systems that rely on relationships between a myriad of different actors with divergent agendas and backgrounds. Relationship is a crucial element of governance, and relationship building an important aspect of partnerships. To understand PPPs a multi-disciplinary perspective that draws on insights from social theory is needed. This paper demonstrates how social theory can aid the understanding of the complex relationships of actors involved in implementation of Public-Private Mix (PPM)-TB policy in India. Ethnographic research was conducted within a district in a Southern state of India over a 14 month period, combining participant observations, informal interactions and in-depth interviews with a wide range of respondents across public, private and non-government organisation (NGO) sectors. Drawing on the theoretical insights from Bourdieu's "theory of practice" this study explores the relationships between the different actors. The study found that programme managers, frontline TB workers, NGOs, and private practitioners all had a crucial role to play in TB partnerships. They were widely regarded as valued contributors with distinct social skills and capabilities within their organizations and professions. However, their potential contributions towards programme implementation tended to be unrecognized both at the top and bottom of the policy implementation chain. These actors constantly struggled for recognition and used different mechanisms to position themselves alongside other actors within the programme that further complicated the relationships between different actors. This paper demonstrates that applying social theory can enable a better understanding of the complex relationship across public, private and NGO sectors. A closer understanding of these processes is a prerequisite for bridging the gap between field-level practices and central policy intentions, facilitating a move towards more effective partnership strategies for strengthening local health systems. The study contributes to our understanding of implementation of PPP for TB control and builds knowledge to help policy makers and programme managers strengthen and effectively implement strategies to enable stronger governance of these partnerships.

The relationship between pelagic larval duration and range size in tropical reef fishes: a synthetic analysis

PubMed Central

Lester, Sarah E; Ruttenberg, Benjamin I

2005-01-01

We address the conflict in earlier results regarding the relationship between dispersal potential and range size. We examine all published pelagic larval duration data for tropical reef fishes. Larval duration is a convenient surrogate for dispersal potential in marine species that are sedentary as adults and that therefore only experience significant dispersal during their larval phase. Such extensive quantitative dispersal data are only available for fishes and thus we use a unique dataset to examine the relationship between dispersal potential and range size. We find that dispersal potential and range size are positively correlated only in the largest ocean basin, the Indo-Pacific, and that this pattern is driven primarily by the spatial distribution of habitat and dispersal barriers. Furthermore, the relationship strengthens at higher taxonomic levels, suggesting an evolutionary mechanism. We document a negative correlation between species richness and larval duration at the family level in the Indo-Pacific, implying that speciation rate may be negatively related to dispersal potential. If increased speciation rate within a taxonomic group results in smaller range sizes within that group, speciation rate could regulate the association between range size and dispersal potential. PMID:16007745

Mining author relationship in scholarly networks based on tripartite citation analysis

PubMed Central

Wang, Xiaohan; Yang, Siluo

2017-01-01

Following scholars in Scientometrics as examples, we develop five author relationship networks, namely, co-authorship, author co-citation (AC), author bibliographic coupling (ABC), author direct citation (ADC), and author keyword coupling (AKC). The time frame of data sets is divided into two periods: before 2011 (i.e., T1) and after 2011 (i.e., T2). Through quadratic assignment procedure analysis, we found that some authors have ABC or AC relationships (i.e., potential communication relationship, PCR) but do not have actual collaborations or direct citations (i.e., actual communication relationship, ACR) among them. In addition, we noticed that PCR and AKC are highly correlated and that the old PCR and the new ACR are correlated and consistent. Such facts indicate that PCR tends to produce academic exchanges based on similar themes, and ABC bears more advantages in predicting potential relations. Based on tripartite citation analysis, including AC, ABC, and ADC, we also present an author-relation mining process. Such process can be used to detect deep and potential author relationships. We analyze the prediction capacity by comparing between the T1 and T2 periods, which demonstrate that relation mining can be complementary in identifying authors based on similar themes and discovering more potential collaborations and academic communities. PMID:29117198

Unjamming and cell shape in the asthmatic airway epithelium

NASA Astrophysics Data System (ADS)

Park, Jin-Ah; Kim, Jae Hun; Bi, Dapeng; Mitchel, Jennifer A.; Qazvini, Nader Taheri; Tantisira, Kelan; Park, Chan Young; McGill, Maureen; Kim, Sae-Hoon; Gweon, Bomi; Notbohm, Jacob; Steward, Robert, Jr.; Burger, Stephanie; Randell, Scott H.; Kho, Alvin T.; Tambe, Dhananjay T.; Hardin, Corey; Shore, Stephanie A.; Israel, Elliot; Weitz, David A.; Tschumperlin, Daniel J.; Henske, Elizabeth P.; Weiss, Scott T.; Manning, M. Lisa; Butler, James P.; Drazen, Jeffrey M.; Fredberg, Jeffrey J.

2015-10-01

From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems--both inert and living--have the potential to jam. The collective can sometimes flow like a fluid or jam and rigidify like a solid. The unjammed-to-jammed transition remains poorly understood, however, and structural properties characterizing these phases remain unknown. Using primary human bronchial epithelial cells, we show that the jamming transition in asthma is linked to cell shape, thus establishing in that system a structural criterion for cell jamming. Surprisingly, the collapse of critical scaling predicts a counter-intuitive relationship between jamming, cell shape and cell-cell adhesive stresses that is borne out by direct experimental observations. Cell shape thus provides a rigorous structural signature for classification and investigation of bronchial epithelial layer jamming in asthma, and potentially in any process in disease or development in which epithelial dynamics play a prominent role.

Evaluation of the membrane permeability (PAMPA and skin) of benzimidazoles with potential cannabinoid activity and their relation with the Biopharmaceutics Classification System (BCS).

PubMed

Alvarez-Figueroa, M Javiera; Pessoa-Mahana, C David; Palavecino-González, M Elisa; Mella-Raipán, Jaime; Espinosa-Bustos, Cristián; Lagos-Muñoz, Manuel E

2011-06-01

The permeability of five benzimidazole derivates with potential cannabinoid activity was determined in two models of membranes, parallel artificial membrane permeability assay (PAMPA) and skin, in order to study the relationship of the physicochemical properties of the molecules and characteristics of the membranes with the permeability defined by the Biopharmaceutics Classification System. It was established that the PAMPA intestinal absorption method is a good predictor for classifying these molecules as very permeable, independent of their thermodynamic solubility, if and only if these have a Log P(oct) value <3.0. In contrast, transdermal permeability is conditioned on the solubility of the molecule so that it can only serve as a model for classifying the permeability of molecules that possess high solubility (class I: high solubility, high permeability; class III: high solubility, low permeability).

Understanding the medical and nonmedical value of diagnostic testing.

PubMed

Lee, David W; Neumann, Peter J; Rizzo, John A

2010-01-01

To develop a framework for defining the potential value of diagnostic testing, and discuss its implications for the health-care delivery system. We reviewed the conceptual and empirical literature related to the valuing of diagnostic tests, and used this information to create a framework for characterizing their value. We then made inferences about the impact of this framework on health insurance coverage, health technology assessment, physician-patient relationships, and public health policy. Three dimensions can effectively classify the potential value created by diagnostic tests: 1) medical value (impact on treatment decisions); 2) planning value (affect on patients' ability to make better life decisions); and 3) psychic value (how test information affects patients' sense of self). This comprehensive framework for valuing diagnostics suggests that existing health technology assessments may systematically under- or overvalue diagnostics, leading to potentially incorrect conclusions about cost-effectiveness. Further, failure to account for all value dimensions may lead to distorted payments under a value-based health-care system. The potential value created by medical diagnostics incorporates medical value as well as value associated with well-being and planning. Consideration of all three dimensions has important implications for technology assessment and value-based payment.

Identifying Ant-Mirid Spatial Interactions to Improve Biological Control in Cacao-Based Agroforestry System.

PubMed

Bagny Beilhe, Leïla; Piou, Cyril; Tadu, Zéphirin; Babin, Régis

2018-06-06

The use of ants for biological control of insect pests was the first reported case of conservation biological control. Direct and indirect community interactions between ants and pests lead to differential spatial pattern. We investigated spatial interactions between mirids, the major cocoa pest in West Africa and numerically dominant ant species, using bivariate point pattern analysis to identify potential biological control agents. We assume that potential biological control agents should display negative spatial interactions with mirids considering their niche overlap. The mirid/ant data were collected in complex cacao-based agroforestry systems sampled in three agroecological areas over a forest-savannah gradient in Cameroon. Three species, Crematogaster striatula Emery (Hymenoptera: Formicidae), Crematogaster clariventris Mayr (Hymenoptera: Formicidae), and Oecophylla longinoda Latreille (Hymenoptera: Formicidae) with high predator and aggressive behaviors were identified as dominant and showed negative spatial relationships with mirids. The weaver ant, O. longinoda was identified as the only potential biological control agent, considering its ubiquity in the plots, the similarity in niche requirements, and the spatial segregation with mirids resulting probably from exclusion mechanisms. Combining bivariate point pattern analysis to good knowledge of insect ecology was an effective method to identify a potentially good biological control agent.

Promiscuity in mice is associated with increased vaginal bacterial diversity

NASA Astrophysics Data System (ADS)

Macmanes, Matthew David

2011-11-01

Differences in the number of sexual partners (i.e., mating system) have the potential to exert a strong influence on the bacterial communities present in reproductive structures like the vagina. Because this structure serves as a conduit for gametes, bacteria present there may have a pronounced, direct effect on host reproductive success. As a first step towards the identification of the relationship between sexual behavior and potentially pathogenic bacterial communities inhabiting vital reproductive structures, as well as their potential effects on fitness, I sought to quantify differences in bacterial diversity in a promiscuous and monogamous mammal species. To accomplish this, I used two sympatric species of Peromyscus rodents— Peromyscus californicus and Peromyscus maniculatus that differ with regard to the number of sexual partners per individual to test the hypothesis that bacterial diversity should be greater in the promiscuous P. maniculatus relative to the monogamous P. californicus. As predicted, phylogenetically controlled and operational taxonomic unit-based indices of bacterial diversity indicated that diversity is greater in the promiscuous species. These results provide important new insights into the effects of mating system on bacterial diversity in free-living vertebrates, and may suggest a potential cost of promiscuity.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Love, A H

Science-based decision making required robust and high-fidelity mechanistic data about the system dynamics and impacts of system changes. Alkaloid cyanotoxins have the characteristics to warrant consideration for their potential threat. Since insufficient information is available to construct a systems model for the alkaloid cyanotoxins, saxitoxins, anatoxins, and anatoxin-a(S), an accurate assessments of these toxins as a potential threat for use for intentional contamination is not possible. Alkaloid cyanotoxin research that contributed to such a model has numerous areas of overlap for natural and intentional health effects issues that generates dual improvements to the state of the science. The use ofmore » sensitivity analyses of systems models can identify parameters that, when determined, result in the greatest impact to the overall system and may help to direct the most efficient use of research funding. This type of modeling-assisted experimentation may allow rapid progress for overall system understanding compared to observational or disciplinary research agendas. Assessment and management of risk from intentional contamination can be performed with greater confidence when mechanisms are known and the relationships between different components are validated. This level of understanding allows high-fidelity assessments that do not hamper legitimate possession of these toxins for research purposes, while preventing intentional contamination that would affect public health. It also allows for appropriate response to an intentional contamination event, even if the specific contamination had not been previous considered. Development of science-based decision making tools will only improve our ability to address the new requirements addressing potential threats to our nation.« less

Three-dimensional interactive and stereotactic atlas of head muscles and glands correlated with cranial nerves and surface and sectional neuroanatomy.

PubMed

Nowinski, Wieslaw L; Chua, Beng Choon; Johnson, Aleksandra; Qian, Guoyu; Poh, Lan Eng; Yi, Su Hnin Wut; Bivi, Aminah; Nowinska, Natalia G

2013-04-30

Three-dimensional (3D) relationships between head muscles and cranial nerves innervating them are complicated. Existing sources present these relationships in illustrations, radiologic scans, or autopsy photographs, which are limited for learning and use. Developed electronic atlases are limited in content, quality, functionality, and/or presentation. We create a truly 3D interactive, stereotactic and high quality atlas, which provides spatial relationships among head muscles, glands and cranial nerves, and correlates them to surface and sectional neuroanatomy. The head muscles and glands were created from a 3T scan by contouring them and generating 3D models. They were named and structured according to Terminologia anatomica. The muscles were divided into: extra-ocular, facial, masticatory and other muscles, and glands into mouth and other glands. The muscles, glands (and also head) were placed in a stereotactic coordinate system. This content was integrated with cranial nerves and neuroanatomy created earlier. To explore this complex content, a scalable user interface was designed with 12 modules including central nervous system (cerebrum, cerebellum, brainstem, spinal cord), cranial nerves, muscles, glands, arterial system, venous system, tracts, deep gray nuclei, ventricles, white matter, visual system, head. Anatomy exploration operations include compositing/decompositing, individual/group selection, 3D view-index mapping, 3D labeling, highlighting, distance measuring, 3D brain cutting, and axial/coronal/sagittal triplanar display. To our best knowledge, this is the first truly 3D, stereotactic, interactive, fairly complete atlas of head muscles, and the first attempt to create a 3D stereotactic atlas of glands. Its use ranges from education of students and patients to research to potential clinical applications. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

A knowledgebase system to enhance scientific discovery: Telemakus

PubMed Central

Fuller, Sherrilynne S; Revere, Debra; Bugni, Paul F; Martin, George M

2004-01-01

Background With the rapid expansion of scientific research, the ability to effectively find or integrate new domain knowledge in the sciences is proving increasingly difficult. Efforts to improve and speed up scientific discovery are being explored on a number of fronts. However, much of this work is based on traditional search and retrieval approaches and the bibliographic citation presentation format remains unchanged. Methods Case study. Results The Telemakus KnowledgeBase System provides flexible new tools for creating knowledgebases to facilitate retrieval and review of scientific research reports. In formalizing the representation of the research methods and results of scientific reports, Telemakus offers a potential strategy to enhance the scientific discovery process. While other research has demonstrated that aggregating and analyzing research findings across domains augments knowledge discovery, the Telemakus system is unique in combining document surrogates with interactive concept maps of linked relationships across groups of research reports. Conclusion Based on how scientists conduct research and read the literature, the Telemakus KnowledgeBase System brings together three innovations in analyzing, displaying and summarizing research reports across a domain: (1) research report schema, a document surrogate of extracted research methods and findings presented in a consistent and structured schema format which mimics the research process itself and provides a high-level surrogate to facilitate searching and rapid review of retrieved documents; (2) research findings, used to index the documents, allowing searchers to request, for example, research studies which have studied the relationship between neoplasms and vitamin E; and (3) visual exploration interface of linked relationships for interactive querying of research findings across the knowledgebase and graphical displays of what is known as well as, through gaps in the map, what is yet to be tested. The rationale and system architecture are described and plans for the future are discussed. PMID:15507158

The potential of toxin-based drug delivery systems for enhanced nucleic acid therapeutic delivery.

PubMed

Shorter, Susan A; Gollings, Alexander S; Gorringe-Pattrick, Monique A M; Coakley, J Emma; Dyer, Paul D R; Richardson, Simon C W

2017-05-01

The potential of gene replacement therapy has been underscored by the market authorization of alipogene tiparvovec (Glybera) and GSK2696273 (Strimvelis) in the EU and recombinant adenovirus-p53 (Gendicine) in China. Common to these systems is the use of attenuated viruses for 'drug' delivery. Whilst viral delivery systems are being developed for siRNA, their application to antisense delivery remains problematic. Non-viral delivery remains experimental, with some notable successes. However, stability and the 'PEG dilemma', balancing toxicity and limited (often liver-tropic) pharmacokinetics/oharmacodynamics, with the membrane destabilizing activity, necessary for nucleocytosolic access and transfection remain a problem. Areas covered: Here we review the use of attenuated protein toxins as a delivery vehicle for nucleic acids, their relationship to the PEG dilemma, and their biological properties with specific reference to their intracellular trafficking. Expert opinion: The possibility of using attenuated toxins as antisense and siRNA delivery systems has been demonstrated in vitro. Systems based upon attenuated anthrax toxin have been shown to have high activity (equivalent to nucleofection) and low toxicity whilst not requiring cationic 'helpers' or condensing agents, divorcing these systems from the problems associated with the PEG dilemma. It remains to be seen whether these systems can operate safely, efficiently and reproducibly, in vivo or in the clinic.

NATO’s Future Role in Europe: Toward a More Political Alliance in a Stable 1 1/2 Bloc System

DTIC Science & Technology

1990-05-01

response along the entire spectrum of potential aggression. In the event deterrence failed, the stategy called for a controlled, measured response... market economy, and a benign Soviet external policy are not made inevitable simply because they are desir- able. Russia has a long history of...bility and peace. • A mixed relationship, involving a combination of accord and competition, in which stability is achieved through a political

The Use of Systemic-Functional Linguistics in Automated Text Mining

DTIC Science & Technology

2009-03-01

what degree two or more documents are similar in terms of their meaning. Simply put, such a cognitive model aims to link the physical manifestation...These features, both in terms of frequency and their chaining across a text, were taken as salient stylistic features that had a direct relationship to...because SFL attempts to model these cognitive processes, this has the potential to improve NLP tasks by making them more ’human-like’. Secondly

Profound Effects of Population Density on Fitness-Related Traits in an Invasive Freshwater Snail

PubMed Central

Zachar, Nicholas; Neiman, Maurine

2013-01-01

Population density can profoundly influence fitness-related traits and population dynamics, and density dependence plays a key role in many prominent ecological and evolutionary hypotheses. Here, we evaluated how individual-level changes in population density affect growth rate and embryo production early in reproductive maturity in two different asexual lineages of Potamopyrgus antipodarum, a New Zealand freshwater snail that is an important model system for ecotoxicology and the evolution of sexual reproduction as well as a potentially destructive worldwide invader. We showed that population density had a major influence on individual growth rate and early-maturity embryo production, effects that were often apparent even when comparing treatments that differed in population density by only one individual. While individual growth rate generally decreased as population density increased, we detected a hump-shaped relationship between embryo production and density, with females from intermediate-density treatments producing the most embryos and females from low- and high-density treatments producing the fewest embryos. The two lineages responded similarly to the treatments, indicating that these effects of population density might apply more broadly across P. antipodarum. These results indicate that there are profound and complex relationships between population density, growth rate, and early-maturity embryo production in at least two lineages of this important model system, with potential implications for the study of invasive populations, research on the maintenance of sex, and approaches used in ecotoxicology. PMID:24278240

Profound effects of population density on fitness-related traits in an invasive freshwater snail.

PubMed

Zachar, Nicholas; Neiman, Maurine

2013-01-01

Population density can profoundly influence fitness-related traits and population dynamics, and density dependence plays a key role in many prominent ecological and evolutionary hypotheses. Here, we evaluated how individual-level changes in population density affect growth rate and embryo production early in reproductive maturity in two different asexual lineages of Potamopyrgus antipodarum, a New Zealand freshwater snail that is an important model system for ecotoxicology and the evolution of sexual reproduction as well as a potentially destructive worldwide invader. We showed that population density had a major influence on individual growth rate and early-maturity embryo production, effects that were often apparent even when comparing treatments that differed in population density by only one individual. While individual growth rate generally decreased as population density increased, we detected a hump-shaped relationship between embryo production and density, with females from intermediate-density treatments producing the most embryos and females from low- and high-density treatments producing the fewest embryos. The two lineages responded similarly to the treatments, indicating that these effects of population density might apply more broadly across P. antipodarum. These results indicate that there are profound and complex relationships between population density, growth rate, and early-maturity embryo production in at least two lineages of this important model system, with potential implications for the study of invasive populations, research on the maintenance of sex, and approaches used in ecotoxicology.

Aflatoxin Exposure During Pregnancy, Maternal Anemia, and Adverse Birth Outcomes

PubMed Central

Smith, Laura E.; Prendergast, Andrew J.; Turner, Paul C.; Humphrey, Jean H.; Stoltzfus, Rebecca J.

2017-01-01

Pregnant women and their developing fetuses are vulnerable to multiple environmental insults, including exposure to aflatoxin, a mycotoxin that may contaminate as much as 25% of the world food supply. We reviewed and integrated findings from studies of aflatoxin exposure during pregnancy and evaluated potential links to adverse pregnancy outcomes. We identified 27 studies (10 human cross-sectional studies and 17 animal studies) assessing the relationship between aflatoxin exposure and adverse birth outcomes or anemia. Findings suggest that aflatoxin exposure during pregnancy may impair fetal growth. Only one human study investigated aflatoxin exposure and prematurity, and no studies investigated its relationship with pregnancy loss, but animal studies suggest aflatoxin exposure may increase risk for prematurity and pregnancy loss. The fetus could be affected by maternal aflatoxin exposure through direct toxicity as well as indirect toxicity, via maternal systemic inflammation, impaired placental growth, or elevation of placental cytokines. The cytotoxic and systemic effects of aflatoxin could plausibly mediate maternal anemia, intrauterine growth restriction, fetal loss, and preterm birth. Given the widespread exposure to this toxin in developing countries, longitudinal studies in pregnant women are needed to provide stronger evidence for the role of aflatoxin in adverse pregnancy outcomes, and to explore biological mechanisms. Potential pathways for intervention to reduce aflatoxin exposure are urgently needed, and this might reduce the global burden of stillbirth, preterm birth, and low birthweight. PMID:28500823

Aflatoxin Exposure During Pregnancy, Maternal Anemia, and Adverse Birth Outcomes.

PubMed

Smith, Laura E; Prendergast, Andrew J; Turner, Paul C; Humphrey, Jean H; Stoltzfus, Rebecca J

2017-04-01

AbstractPregnant women and their developing fetuses are vulnerable to multiple environmental insults, including exposure to aflatoxin, a mycotoxin that may contaminate as much as 25% of the world food supply. We reviewed and integrated findings from studies of aflatoxin exposure during pregnancy and evaluated potential links to adverse pregnancy outcomes. We identified 27 studies (10 human cross-sectional studies and 17 animal studies) assessing the relationship between aflatoxin exposure and adverse birth outcomes or anemia. Findings suggest that aflatoxin exposure during pregnancy may impair fetal growth. Only one human study investigated aflatoxin exposure and prematurity, and no studies investigated its relationship with pregnancy loss, but animal studies suggest aflatoxin exposure may increase risk for prematurity and pregnancy loss. The fetus could be affected by maternal aflatoxin exposure through direct toxicity as well as indirect toxicity, via maternal systemic inflammation, impaired placental growth, or elevation of placental cytokines. The cytotoxic and systemic effects of aflatoxin could plausibly mediate maternal anemia, intrauterine growth restriction, fetal loss, and preterm birth. Given the widespread exposure to this toxin in developing countries, longitudinal studies in pregnant women are needed to provide stronger evidence for the role of aflatoxin in adverse pregnancy outcomes, and to explore biological mechanisms. Potential pathways for intervention to reduce aflatoxin exposure are urgently needed, and this might reduce the global burden of stillbirth, preterm birth, and low birthweight.

Potentially traumatic events and mental health problems among children of Iraqi refugees: The roles of relationships with parents and feelings about school.

PubMed

Trentacosta, Christopher J; McLear, Caitlin M; Ziadni, Maisa S; Lumley, Mark A; Arfken, Cynthia L

2016-01-01

This study examined mental health problems among children of Iraqi refugees, most of whom were Christian. Exposure to potentially traumatic events was hypothesized to predict more symptoms of depression and traumatic stress. Moreover, youth reports of supportive relationships with parents and positive feelings about school were examined in relation to mental health problems. These promotive factors were expected to mitigate the hypothesized association between traumatic event exposure and mental health problems. Participants were 211 youth recruited from agencies and programs serving Iraqi refugees in a large metropolitan area in the United States. The hypotheses were partially supported. Youth who reported experiencing more potentially traumatic events endorsed more traumatic stress and depression symptoms. After accounting for exposure to potentially traumatic events and other covariates, youth who reported more positive feelings about school endorsed fewer symptoms of traumatic stress, and youth who reported more supportive relationships with parents endorsed fewer symptoms of depression. In addition, there was an interaction between potentially traumatic events and relationships with parents when predicting depression symptoms. Youth endorsed higher levels of depression symptoms when they reported less supportive relationships, regardless of the amount of traumatic event exposure, whereas youth endorsed lower levels of depression symptoms when they reported more supportive relationships with parents, but only at low levels of traumatic event exposure. Otherwise, the main effects were not qualified by interactions between potentially traumatic event exposure and the promotive factors. The findings from this study have implications for future research, policy, and practice with children of refugees. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Mechanisms of Gain Control by Voltage-Gated Channels in Intrinsically-Firing Neurons

PubMed Central

Patel, Ameera X.; Burdakov, Denis

2015-01-01

Gain modulation is a key feature of neural information processing, but underlying mechanisms remain unclear. In single neurons, gain can be measured as the slope of the current-frequency (input-output) relationship over any given range of inputs. While much work has focused on the control of basal firing rates and spike rate adaptation, gain control has been relatively unstudied. Of the limited studies on gain control, some have examined the roles of synaptic noise and passive somatic currents, but the roles of voltage-gated channels present ubiquitously in neurons have been less explored. Here, we systematically examined the relationship between gain and voltage-gated ion channels in a conductance-based, tonically-active, model neuron. Changes in expression (conductance density) of voltage-gated channels increased (Ca2+ channel), reduced (K+ channels), or produced little effect (h-type channel) on gain. We found that the gain-controlling ability of channels increased exponentially with the steepness of their activation within the dynamic voltage window (voltage range associated with firing). For depolarization-activated channels, this produced a greater channel current per action potential at higher firing rates. This allowed these channels to modulate gain by contributing to firing preferentially at states of higher excitation. A finer analysis of the current-voltage relationship during tonic firing identified narrow voltage windows at which the gain-modulating channels exerted their effects. As a proof of concept, we show that h-type channels can be tuned to modulate gain by changing the steepness of their activation within the dynamic voltage window. These results show how the impact of an ion channel on gain can be predicted from the relationship between channel kinetics and the membrane potential during firing. This is potentially relevant to understanding input-output scaling in a wide class of neurons found throughout the brain and other nervous systems. PMID:25816008

Modeling and Assimilating Ocean Color Radiances

NASA Technical Reports Server (NTRS)

Gregg, Watson

2012-01-01

Radiances are the source of information from ocean color sensors to produce estimates of biological and geochemical constituents. They potentially provide information on various other aspects of global biological and chemical systems, and there is considerable work involved in deriving new information from these signals. Each derived product, however, contains errors that are derived from the application of the radiances, above and beyond the radiance errors. A global biogeochemical model with an explicit spectral radiative transfer model is used to investigate the potential of assimilating radiances. The results indicate gaps in our understanding of radiative processes in the oceans and their relationships with biogeochemical variables. Most important, detritus optical properties are not well characterized and produce important effects of the simulated radiances. Specifically, there does not appear to be a relationship between detrital biomass and its optical properties, as there is for chlorophyll. Approximations are necessary to get beyond this problem. In this reprt we will discuss the challenges in modeling and assimilation water-leaving radiances and the prospects for improving our understanding of biogeochemical process by utilizing these signals.

Conjugated polymer energy level shifts in lithium-ion battery electrolytes.

PubMed

Song, Charles Kiseok; Eckstein, Brian J; Tam, Teck Lip Dexter; Trahey, Lynn; Marks, Tobin J

2014-11-12

The ionization potentials (IPs) and electron affinities (EAs) of widely used conjugated polymers are evaluated by cyclic voltammetry (CV) in conventional electrochemical and lithium-ion battery media, and also by ultraviolet photoelectron spectroscopy (UPS) in vacuo. By comparing the data obtained in the different systems, it is found that the IPs of the conjugated polymer films determined by conventional CV (IPC) can be correlated with UPS-measured HOMO energy levels (EH,UPS) by the relationship EH,UPS = (1.14 ± 0.23) × qIPC + (4.62 ± 0.10) eV, where q is the electron charge. It is also found that the EAs of the conjugated polymer films measured via CV in conventional (EAC) and Li(+) battery (EAB) media can be linearly correlated by the relationship EAB = (1.07 ± 0.13) × EAC + (2.84 ± 0.22) V. The slopes and intercepts of these equations can be correlated with the dielectric constants of the polymer film environments and the redox potentials of the reference electrodes, as modified by the surrounding electrolyte, respectively.

Effects of engineered nanoparticles on the innate immune system.

PubMed

Liu, Yuanchang; Hardie, Joseph; Zhang, Xianzhi; Rotello, Vincent M

2017-12-01

Engineered nanoparticles (NPs) have broad applications in industry and nanomedicine. When NPs enter the body, interactions with the immune system are unavoidable. The innate immune system, a non-specific first line of defense against potential threats to the host, immediately interacts with introduced NPs and generates complicated immune responses. Depending on their physicochemical properties, NPs can interact with cells and proteins to stimulate or suppress the innate immune response, and similarly activate or avoid the complement system. NPs size, shape, hydrophobicity and surface modification are the main factors that influence the interactions between NPs and the innate immune system. In this review, we will focus on recent reports about the relationship between the physicochemical properties of NPs and their innate immune response, and their applications in immunotherapy. Copyright © 2017 Elsevier Ltd. All rights reserved.

Functional network organization of the human brain

PubMed Central

Power, Jonathan D; Cohen, Alexander L; Nelson, Steven M; Wig, Gagan S; Barnes, Kelly Anne; Church, Jessica A; Vogel, Alecia C; Laumann, Timothy O; Miezin, Fran M; Schlaggar, Bradley L; Petersen, Steven E

2011-01-01

Summary Real-world complex systems may be mathematically modeled as graphs, revealing properties of the system. Here we study graphs of functional brain organization in healthy adults using resting state functional connectivity MRI. We propose two novel brain-wide graphs, one of 264 putative functional areas, the other a modification of voxelwise networks that eliminates potentially artificial short-distance relationships. These graphs contain many subgraphs in good agreement with known functional brain systems. Other subgraphs lack established functional identities; we suggest possible functional characteristics for these subgraphs. Further, graph measures of the areal network indicate that the default mode subgraph shares network properties with sensory and motor subgraphs: it is internally integrated but isolated from other subgraphs, much like a “processing” system. The modified voxelwise graph also reveals spatial motifs in the patterning of systems across the cortex. PMID:22099467

Physio-climatic controls on vulnerability of watersheds to climate and land use change across the U. S.

NASA Astrophysics Data System (ADS)

Deshmukh, Ankit; Singh, Riddhi

2016-11-01

Understanding how a watershed's physio-climatic characteristics affect its vulnerability to environmental (climatic and land use) change is crucial for managing these complex systems. In this study, we combine the strengths of recently developed exploratory modeling frameworks and comparative hydrology to quantify the relationship between watershed's vulnerability and its physio-climatic characteristics. We propose a definition of vulnerability that can be used by a diverse range of water system managers and is useful in the presence of large uncertainties in drivers of environmental change. This definition is related to adverse climate change and land use thresholds that are quantified using a recently developed exploratory modeling approach. In this way, we estimate the vulnerability of 69 watersheds in the United States to climate and land use change. We explore definitions of vulnerability that describe average or extreme flow conditions, as well as others that are relevant from the point of view of instream organisms. In order to understand the dominant controls on vulnerability, we correlate these indices with watershed's characteristics describing its topography, geology, drainage, climate, and land use. We find that mean annual flow is more vulnerable to reductions in precipitation in watersheds with lower average soil permeability, lower baseflow index, lower forest cover, higher topographical wetness index, and vice-versa. Our results also indicate a potential mediation of climate change impacts by regional groundwater systems. By developing such relationships across a large range of watersheds, such information can potentially be used to assess the vulnerability of ungauged watersheds to uncertain environmental change.

A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility

PubMed Central

Sharp, Julia L.; Edelson, Stephen M.; Kelly, Desmond P.; Casanova, Manuel F.

2018-01-01

Reports suggest comorbidity between autism spectrum disorder (ASD) and the connective tissue disorder, Ehlers-Danlos syndrome (EDS). People with EDS and the broader spectrum of Generalized Joint Hypermobility (GJH) often present with immune- and endocrine-mediated conditions. Meanwhile, immune/endocrine dysregulation is a popular theme in autism research. We surveyed a group of ASD women with/without GJH to determine differences in immune/endocrine exophenotypes. ASD women 25 years or older were invited to participate in an online survey. Respondents completed a questionnaire concerning diagnoses, immune/endocrine symptom history, experiences with pain, and seizure history. ASD women with GJH (ASD/GJH) reported more immune- and endocrine-mediated conditions than their non-GJH counterparts (p = 0.001). Autoimmune conditions were especially prominent in the ASD/GJH group (p = 0.027). Presence of immune-mediated symptoms often co-occurred with one another (p < 0.001–0.020), as did endocrine-mediated symptoms (p < 0.001–0.045), irrespective of the group. Finally, the numbers of immune- and endocrine-mediated symptoms shared a strong inter-relationship (p < 0.001), suggesting potential system crosstalk. While our results cannot estimate comorbidity, they reinforce concepts of an etiological relationship between ASD and GJH. Meanwhile, women with ASD/GJH have complex immune/endocrine exophenotypes compared to their non-GJH counterparts. Further, we discuss how connective tissue regulates the immune system and how the immune/endocrine systems in turn may modulate collagen synthesis, potentially leading to higher rates of GJH in this subpopulation. PMID:29562607

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

PubMed Central

Bal-Price, Anna; Lein, Pamela J.; Keil, Kimberly P.; Sethi, Sunjay; Shafer, Timothy; Barenys, Marta; Fritsche, Ellen; Sachana, Magdalini; Meek, M.E. (Bette)

2016-01-01

The Adverse Outcome Pathway (AOP) concept has recently been proposed to support a paradigm shift in regulatory toxicology testing and risk assessment. This concept is similar to the Mode of Action (MOA), in that it describes a sequence of measurable key events triggered by a molecular initiating event in which a stressor interacts with a biological target. The resulting cascade of key events includes molecular, cellular, structural and functional changes in biological systems, resulting in a measurable adverse outcome. Thereby, an AOP ideally provides information relevant to chemical structure-activity relationships as a basis for predicting effects of structurally similar compounds. AOPs could potentially also form the basis for qualitative and quantitative predictive modeling of the human adverse outcome resulting from molecular initiating or other key events for which higher-throughput testing methods are available or can be developed. A variety of cellular and molecular processes are known to be critical for normal function of the central (CNS) and peripheral nervous systems (PNS). Because of the biological and functional complexity of the CNS and PNS, it has been challenging to establish causative links and quantitative relationships between key events that comprise the pathways leading from chemical exposure to an adverse outcome in the nervous system. Following introduction of the principles of MOA and AOPs, examples of potential or putative adverse outcome pathways specific for developmental or adult neurotoxicity are summarized and aspects of their assessment considered. Their possible application in developing mechanistically informed Integrated Approaches to Testing and Assessment (IATA) is also discussed. PMID:27212452

Land Management, River Restoration and the Water Framework Directive

NASA Astrophysics Data System (ADS)

Smith, Ben; Clifford, Nicholas

2014-05-01

The influence of catchment land-use on river ecosystems is well established, with negative changes in hydrology, sediment supply and pollutants causing widespread degradation in modified catchments across Europe. The strength of relationship found between different land-use types and impacts on river systems varies from study to study as a result of issues around data quality, scale, study design and the interaction of stressors at multiple scales. Analysis of large-scale datasets can provide important information about the way that catchments pressures affect WFD objectives at a national scale. Comparisons of relationships between land-use and WFD status in different types of catchment within the UK allow an assessment of catchment sensitivity and analysis of the catchment characteristics which influence these relationships. The results suggest prioritising catchments at or near land-use thresholds, or targeting waterbodies with limited land-use pressures but which are failing to achieve GES or GEP. This paper uses UK datasets on land cover and WFD waterbody status to examine how catchment land-use impacts on WFD status and to evaluate opportunities to achieve Good Ecological Status or Good Ecological Potential. Agricultural and urban land-use are shown to have different types of relationship with respect to the likelihood of achieving Good Ecological Status, and with clear threshold effects apparent for urban land-use in the catchment. Broad-scale analysis shows the influence of different sized buffer strips in mitigating the negative effects of different types of land-cover, and reinforces the positive effects of riparian woodland on river ecosystems and their potential under the WFD.

Adverse events after anthrax vaccination reported to the Vaccine Adverse Event Reporting System (VAERS), 1990-2007.

PubMed

Niu, Manette T; Ball, Robert; Woo, Emily Jane; Burwen, Dale R; Knippen, Maureen; Braun, M Miles

2009-01-07

During the period March 1, 1998 to January 14, 2007, approximately 6 million doses of Anthrax vaccine adsorbed (AVA) vaccine were administered. As of January 16, 2007, 4753 reports of adverse events following receipt of AVA vaccination had been submitted to the Vaccine Adverse Event Reporting System (VAERS). Taken together, reports to VAERS did not definitively link any serious unexpected risk to this vaccine, and review of death and serious reports did not show a distinctive pattern indicative of a causal relationship to AVA vaccination. Continued monitoring of VAERS and analysis of potential associations between AVA vaccination and rare, serious events is warranted.

Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions.

PubMed

Mehanna, Emile; Hamik, Anne; Josephson, Richard A

2016-05-01

Historically, the relationship between exercise and the cardiovascular system was viewed as unidirectional, with a disease resulting in exercise limitation and hazard. This article reviews and explores the bidirectional nature, delineating the effects, generally positive, on the cardiovascular system and atherosclerosis. Exercise augments eNOS, affects redox potential, and favorably affects mediators of atherosclerosis including lipids, glucose homeostasis, and inflammation. There are direct effects on the vasculature as well as indirect benefits related to exercise-induced changes in body composition and skeletal muscle. Application of aerobic exercise to specific populations is described, with the hope that this knowledge will move the science forward and improve individual patient outcome.

Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions

PubMed Central

Mehanna, Emile; Hamik, Anne; Josephson, Richard A

2017-01-01

Historically the relationship between exercise and the cardiovascular system was viewed as unidirectional, with disease resulting in exercise limitation and hazard. This article reviews and explores the bidirectional nature, delineating the effects, generally positive, on the cardiovascular system and atherosclerosis. Exercise augments eNOS, affects redox potential, and favorably affects mediators of atherosclerosis including lipids, glucose homeostasis, and inflammation. There are direct effects on the vasculature as well as indirect benefits related to exercises induced changes in body composition and skeletal muscle. Application of aerobic exercise to specific populations is described, with the hope that this knowledge will move the science forward and improve individual patient outcome. PMID:27005804

Medical Education Capacity-Building Partnerships for Health Care Systems Development.

PubMed

Rabin, Tracy L; Mayanja-Kizza, Harriet; Rastegar, Asghar

2016-07-01

Health care workforce development is a key pillar of global health systems strengthening that requires investment in health care worker training institutions. This can be achieved by developing partnerships between training institutions in resource-limited and resource-rich areas and leveraging the unique expertise and opportunities both have to offer. To realize their full potential, however, these relationships must be equitable. In this article, we use a previously described global health ethics framework and our ten-year experience with the Makerere University-Yale University (MUYU) Collaboration to provide an example of an equity-focused global health education partnership. © 2016 American Medical Association. All Rights Reserved. ISSN 2376-6980.

Voltage-dependent Ca2+ release from the SR of feline ventricular myocytes is explained by Ca2+-induced Ca2+ release

PubMed Central

Piacentino, Valentino; Dipla, Konstantina; Gaughan, John P; Houser, Steven R

2000-01-01

Direct voltage-gated (voltage-dependent Ca2+ release, VDCR) and Ca2+ influx-gated (Ca2+-induced Ca2+ release, CICR) sarcoplasmic reticulum (SR) Ca2+ release were studied in feline ventricular myocytes. The voltage-contraction relationship predicted by the VDCR hypothesis is sigmoidal with large contractions at potentials near the Ca2+ equilibrium potential (ECa). The relationship predicted by the CICR hypothesis is bell-shaped with no contraction at ECa. The voltage dependence of contraction was measured in ventricular myocytes at physiological temperature (37 °C), resting membrane potential and physiological [K+]. Experiments were performed with cyclic adenosine 3′,5′-monophosphate (cAMP) in the pipette or in the presence of the β-adrenergic agonist isoproterenol (isoprenaline; ISO). The voltage-contraction relationship was bell-shaped in Na+-free solutions (to eliminate the Na+ current and Na+-Ca2+ exchange, NCX) but the relationship was broader than the L-type Ca2+ current (ICa,L)-voltage relationship. Contractions induced with voltage steps from normal resting potentials to -40 mV are thought to represent VDCR rather than CICR. We found that cAMP and ISO shifted the voltage dependence of ICa,L activation to more negative potentials so that ICa,L was always present with steps to -40 mV. ICa,L at -40 mV inactivated when the holding potential was decreased (V½ =−57·8 ± 0·49 mV). ISO increased inward current, SR Ca2+ load and contraction in physiological [Na+] and a broad bell-shaped voltage-contraction relationship was observed. Inhibition of reverse-mode NCX, decreasing ICa,L and decreasing SR Ca2+ loading all decreased contractions at strongly positive potentials near ECa. The voltage-contraction relationship in 200 μM cadmium (Cd2+) was bell-shaped, supporting a role of ICa,L rather than VDCR. All results could be accounted for by the CICR hypothesis, and many results exclude the VDCR hypothesis. PMID:10718736

Machine learnt bond order potential to model metal-organic (Co-C) heterostructures.

PubMed

Narayanan, Badri; Chan, Henry; Kinaci, Alper; Sen, Fatih G; Gray, Stephen K; Chan, Maria K Y; Sankaranarayanan, Subramanian K R S

2017-11-30

A fundamental understanding of the inter-relationships between structure, morphology, atomic scale dynamics, chemistry, and physical properties of mixed metallic-covalent systems is essential to design novel functional materials for applications in flexible nano-electronics, energy storage and catalysis. To achieve such knowledge, it is imperative to develop robust and computationally efficient atomistic models that describe atomic interactions accurately within a single framework. Here, we present a unified Tersoff-Brenner type bond order potential (BOP) for a Co-C system, trained against lattice parameters, cohesive energies, equation of state, and elastic constants of different crystalline phases of cobalt as well as orthorhombic Co 2 C derived from density functional theory (DFT) calculations. The independent BOP parameters are determined using a combination of supervised machine learning (genetic algorithms) and local minimization via the simplex method. Our newly developed BOP accurately describes the structural, thermodynamic, mechanical, and surface properties of both the elemental components as well as the carbide phases, in excellent accordance with DFT calculations and experiments. Using our machine-learnt BOP potential, we performed large-scale molecular dynamics simulations to investigate the effect of metal/carbon concentration on the structure and mechanical properties of porous architectures obtained via self-assembly of cobalt nanoparticles and fullerene molecules. Such porous structures have implications in flexible electronics, where materials with high electrical conductivity and low elastic stiffness are desired. Using unsupervised machine learning (clustering), we identify the pore structure, pore-distribution, and metallic conduction pathways in self-assembled structures at different C/Co ratios. We find that as the C/Co ratio increases, the connectivity between the Co nanoparticles becomes limited, likely resulting in low electrical conductivity; on the other hand, such C-rich hybrid structures are highly flexible (i.e., low stiffness). The BOP model developed in this work is a valuable tool to investigate atomic scale processes, structure-property relationships, and temperature/pressure response of Co-C systems, as well as design organic-inorganic hybrid structures with a desired set of properties.

Preliminary Results form the Japanese Total Lightning Network

NASA Astrophysics Data System (ADS)

Hobara, Y.; Ishii, H.; Kumagai, Y.; Liu, C.; Heckman, S.; Price, C. G.; Williams, E. R.

2015-12-01

We report on the initial observational results from the first Japanese Total Lightning Detection Network (JTLN) in relation to severe weather phenomena. The University of Electro-Communications (UEC) has deployed the Earth Networks (EN) Total Lightning System over Japan to carry out research on the relationship between thunderstorm activity and severe weather phenomena since 2013. In this paper we first demonstrate the current status of our new network followed by the initial scientific results. The lightning jump algorithm was applied to our total lightning data to study the relationship between total lighting activity and hazardous weather events such as gust fronts and tornadoes over land reported by the JMA (Japanese Meteorological Agency) in 2014. As a result, a clear increase in total lighting flash rate as well as lightning jumps are observed prior to most hazardous weather events (~20 min) indicating potential usefulness for early warning in Japan. Furthermore we are going to demonstrate the relationship of total lightning activities with meteorological radar data focusing particularly on Japanese Tornadic storms.

Relationship of Temporal Lobe Volumes to Neuropsychological Test Performance in Healthy Children

PubMed Central

Wells, Carolyn T.; Matson, Melissa A.; Kates, Wendy R.; Hay, Trisha; Horska, Alena

2008-01-01

Ecological validity of neuropsychological assessment includes the ability of tests to predict real-world functioning and/or covary with brain structures. Studies have examined the relationship between adaptive skills and test performance, with less focus on the association between regional brain volumes and neurobehavioral function in healthy children. The present study examined the relationship between temporal lobe gray matter volumes and performance on two neuropsychological tests hypothesized to measure temporal lobe functioning (Visual Perception-VP; Peabody Picture Vocabulary Test, Third Edition-PPVT-III) in 48 healthy children ages 5-18 years. After controlling for age and gender, left and right temporal and left occipital volumes were significant predictors of VP. Left and right frontal and temporal volumes were significant predictors of PPVT-III. Temporal volume emerged as the strongest lobar correlate with both tests. These results provide convergent and discriminant validity supporting VP as a measure of the “what” system; but suggest the PPVT-III as a complex measure of receptive vocabulary, potentially involving executive function demands. PMID:18513844

Mindfulness-based interventions with social workers and the potential for enhanced patient-centered care: A systematic review of the literature.

PubMed

Trowbridge, Kelly; Mische Lawson, Lisa

2016-01-01

The use of mindfulness-based interventions (MBIs) is well documented in the mental health, medical, and education literature. There is minimal research on the use of mindfulness with social workers. As demonstrated in other professional and helping fields, mindfulness may enhance clinical skills, reduce burnout, and increase job satisfaction among social workers. In the health care field mindfulness appears integral to patient and family relationships and personal resilience. The evolving and expanding role of hospital social workers may lead to increased work stress and greater demands from both the medical system and patients and families. Research with medical providers, such as physicians and nurses, suggests mindfulness may help in reducing stress, enhancing relationships, and fostering the self-reflection required to provide patient-centered care. We systematically reviewed the existing literature to begin understanding both mindfulness qualities and practices and the effectiveness of MBIs among social workers as well as the relationship of mindfulness to patient-centered care.

The human biology--saturated with experience.

PubMed

Getz, Linn; Kirkengen, Anna Luise; Ulvestad, Elling

2011-04-08

The human being is a self-reflecting, relationship-oriented, goal-directed organism in search of meaning. The process of coordinating and developing knowledge about how experience associated with self-conscience, relationships and values can contribute to development of health and disease is a great challenge for the medical profession. We present a theory-guided synthesis of new scientific knowledge from fields such as epigenetics, psycho-neuro-endocrino-immunology, stress research and systems biology. The sources are articles in acknowledged journals and books, chosen to provide insight into associations between life history (biography) and the human body (biology) in a wide sense. Research shows that information about biography, i.e. experienced meaning and relationships, is literally incorporated into the human organism. Epigenetics illustrates the fundamental biological potential for context-dependent adaptation. Further, studies have shown that different types of existential strain may disturb systems for human physiological adaptation, affect structures in the brain and subsequently render the organism vulnerable for disease. However, a sense of belonging and a perception of being supported and acknowledged can contribute to strengthening or restoring health. The traditional approach to increasing biomedical knowledge has prevented insight into the medical significance of experience. The new knowledge necessitates a reorientation of theory and practice within the medical profession both with respect to individuals and society.

The Relationship between Training and Mental Health among Caregivers of Individuals with Polytrauma

PubMed Central

Pickett, Treven C.; Wilder Schaaf, Kathryn P.; Taylor, Brent C.; Gravely, Amy; Van Houtven, Courtney Harold; Friedemann-Sánchez, Greta; Griffin, Joan M.

2015-01-01

This was a hypothesis-generating exploration of relationships between caregiver training during TBI/polytrauma rehabilitation and caregiver mental health. In this cross-sectional study, 507 informal caregivers to US service members with TBI who received inpatient rehabilitation care in a Veterans Affairs' Polytrauma Rehabilitation Center from 2001 to 2009 completed a retrospective, self-report survey. Embedded in the survey were measures of caregiver mental health, including the National Institutes of Health's Patient Reported Outcome Measurement Information System (PROMIS) Anxiety and Depression Short Forms, the Rosenberg Self-Esteem scale, and the Zarit Burden Short Form. Though no groups endorsed clinical levels, mental health symptoms varied by caregiver training category (Trained, Not Trained, and Did Not Need Training). Caregivers who did not receive training on how to navigate healthcare systems endorsed higher depression and burden and lower self-esteem than those who did. Caregivers who did not receive training in supporting their care recipients' emotions endorsed higher anxiety, depression, and burden and lower self-esteem than those who did. Analyses also suggested a different association between training and mental health based on caregivers' relationship to the care recipient and the intensity of care recipient needs. Potential hypotheses for testing in future studies raised by these findings are discussed. PMID:26770015

Landscape change in the southern Piedmont: challenges, solutions, and uncertainty across scales

USGS Publications Warehouse

Conroy, M.J.; Allen, Craig R.; Peterson, J.T.; Pritchard, L.J.; Moore, C.T.

2003-01-01

The southern Piedmont of the southeastern United States epitomizes the complex and seemingly intractable problems and hard decisions that result from uncontrolled urban and suburban sprawl. Here we consider three recurrent themes in complicated problems involving complex systems: (1) scale dependencies and cross-scale, often nonlinear relationships; (2) resilience, in particular the potential for complex systems to move to alternate stable states with decreased ecological and/or economic value; and (3) uncertainty in the ability to understand and predict outcomes, perhaps particularly those that occur as a result of human impacts. We consider these issues in the context of landscape-level decision making, using as an example water resources and lotic systems in the Piedmont region of the southeastern United States.

Evolutionary Connectionism: Algorithmic Principles Underlying the Evolution of Biological Organisation in Evo-Devo, Evo-Eco and Evolutionary Transitions.

PubMed

Watson, Richard A; Mills, Rob; Buckley, C L; Kouvaris, Kostas; Jackson, Adam; Powers, Simon T; Cox, Chris; Tudge, Simon; Davies, Adam; Kounios, Loizos; Power, Daniel

2016-01-01

The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental organisations modifies the distribution of phenotypic variation, the evolution of ecological relationships modifies the selective environment, and the evolution of reproductive relationships modifies the heritability of the evolutionary unit. The major transitions in evolution, in particular, involve radical changes in developmental, ecological and reproductive organisations that instantiate variation, selection and inheritance at a higher level of biological organisation. However, current evolutionary theory is poorly equipped to describe how these organisations change over evolutionary time and especially how that results in adaptive complexes at successive scales of organisation (the key problem is that evolution is self-referential, i.e. the products of evolution change the parameters of the evolutionary process). Here we first reinterpret the central open questions in these domains from a perspective that emphasises the common underlying themes. We then synthesise the findings from a developing body of work that is building a new theoretical approach to these questions by converting well-understood theory and results from models of cognitive learning. Specifically, connectionist models of memory and learning demonstrate how simple incremental mechanisms, adjusting the relationships between individually-simple components, can produce organisations that exhibit complex system-level behaviours and improve the adaptive capabilities of the system. We use the term "evolutionary connectionism" to recognise that, by functionally equivalent processes, natural selection acting on the relationships within and between evolutionary entities can result in organisations that produce complex system-level behaviours in evolutionary systems and modify the adaptive capabilities of natural selection over time. We review the evidence supporting the functional equivalences between the domains of learning and of evolution, and discuss the potential for this to resolve conceptual problems in our understanding of the evolution of developmental, ecological and reproductive organisations and, in particular, the major evolutionary transitions.

Verifying and Postprocesing the Ensemble Spread-Error Relationship

NASA Astrophysics Data System (ADS)

Hopson, Tom; Knievel, Jason; Liu, Yubao; Roux, Gregory; Wu, Wanli

2013-04-01

With the increased utilization of ensemble forecasts in weather and hydrologic applications, there is a need to verify their benefit over less expensive deterministic forecasts. One such potential benefit of ensemble systems is their capacity to forecast their own forecast error through the ensemble spread-error relationship. The paper begins by revisiting the limitations of the Pearson correlation alone in assessing this relationship. Next, we introduce two new metrics to consider in assessing the utility an ensemble's varying dispersion. We argue there are two aspects of an ensemble's dispersion that should be assessed. First, and perhaps more fundamentally: is there enough variability in the ensembles dispersion to justify the maintenance of an expensive ensemble prediction system (EPS), irrespective of whether the EPS is well-calibrated or not? To diagnose this, the factor that controls the theoretical upper limit of the spread-error correlation can be useful. Secondly, does the variable dispersion of an ensemble relate to variable expectation of forecast error? Representing the spread-error correlation in relation to its theoretical limit can provide a simple diagnostic of this attribute. A context for these concepts is provided by assessing two operational ensembles: 30-member Western US temperature forecasts for the U.S. Army Test and Evaluation Command and 51-member Brahmaputra River flow forecasts of the Climate Forecast and Applications Project for Bangladesh. Both of these systems utilize a postprocessing technique based on quantile regression (QR) under a step-wise forward selection framework leading to ensemble forecasts with both good reliability and sharpness. In addition, the methodology utilizes the ensemble's ability to self-diagnose forecast instability to produce calibrated forecasts with informative skill-spread relationships. We will describe both ensemble systems briefly, review the steps used to calibrate the ensemble forecast, and present verification statistics using error-spread metrics, along with figures from operational ensemble forecasts before and after calibration.

Heat flux from magmatic hydrothermal systems related to availability of fluid recharge

USGS Publications Warehouse

Harvey, M. C.; Rowland, J.V.; Chiodini, G.; Rissmann, C.F.; Bloomberg, S.; Hernandez, P.A.; Mazot, A.; Viveiros, F.; Werner, Cynthia A.

2015-01-01

Magmatic hydrothermal systems are of increasing interest as a renewable energy source. Surface heat flux indicates system resource potential, and can be inferred from soil CO2 flux measurements and fumarole gas chemistry. Here we compile and reanalyze results from previous CO2 flux surveys worldwide to compare heat flux from a variety of magma-hydrothermal areas. We infer that availability of water to recharge magmatic hydrothermal systems is correlated with heat flux. Recharge availability is in turn governed by permeability, structure, lithology, rainfall, topography, and perhaps unsurprisingly, proximity to a large supply of water such as the ocean. The relationship between recharge and heat flux interpreted by this study is consistent with recent numerical modeling that relates hydrothermal system heat output to rainfall catchment area. This result highlights the importance of recharge as a consideration when evaluating hydrothermal systems for electricity generation, and the utility of CO2 flux as a resource evaluation tool.

Growing trend of CE at the omics level: the frontier of systems biology--an update.

PubMed

Ban, Eunmi; Park, Soo Hyun; Kang, Min-Jung; Lee, Hyun-Jung; Song, Eun Joo; Yoo, Young Sook

2012-01-01

Omics is the study of proteins, peptides, genes, and metabolites in living organisms. Systems biology aims to understand the system through the study of the relationship between elements such as genes and proteins in biological system. Recently, systems biology emerged as the result of the advanced development of high-throughput analysis technologies such as DNA sequencers, DNA arrays, and mass spectrometry for omics studies. Among a number of analytical tools and technologies, CE and CE coupled to MS are promising and relatively rapidly developing tools with the potential to provide qualitative and quantitative analyses of biological molecules. With an emphasis on CE for systems biology, this review summarizes the method developments and applications of CE for the genomic, transcriptomic, proteomic, and metabolomic studies focusing on the drug discovery and disease diagnosis and therapies since 2009. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Tephra fall clean-up in urban environments

NASA Astrophysics Data System (ADS)

Hayes, Josh L.; Wilson, Thomas M.; Magill, Christina

2015-10-01

Tephra falls impact urban communities by disrupting transport systems, contaminating and damaging buildings and infrastructures, and are potentially hazardous to human health. Therefore, prompt and effective tephra clean-up measures are an essential component of an urban community's response to tephra fall. This paper reviews case studies of tephra clean-up operations in urban environments around the world, spanning 50 years. It identifies methods used in tephra clean-up and assesses a range of empirical relationships between level of tephra accumulation and clean-up metrics such as collected tephra volume, costs, and duration of operations. Results indicate the volume of tephra collected from urban areas is proportional to tephra accumulation. Urban areas with small tephra accumulations (1,000 m3/km2 or an average of 1 mm thickness) may collect < 1% of the total deposit, whereas urban areas which experience large accumulations (> 50,000 m3/km2 or an average of 50 mm thickness) remove up to 80%. This relationship can inform impact and risk assessments by providing an estimate of the likely response required for a given tephra fall. No strong relationship was found between tephra fall accumulation and clean-up cost or duration for urban environments which received one-off tephra falls, suggesting that these aspects of tephra fall clean-up operations are context specific. Importantly, this study highlights the advantage of effective planning for tephra clean-up and disposal in potentially exposed areas.

Spatial and Temporal Relationships of Stomatal Development and Function in a Temperate Forest Canopy

NASA Astrophysics Data System (ADS)

Dow, G.; Richardson, A. D.

2017-12-01

Mechanisms that control stomatal development ultimately constrain leaf physiology by determining the anatomical maximum rate for gas-exchange (gsmax). However, we know comparatively less about how these regulatory processes define stomatal conductance (gs) and photosynthesis or how this information translates between model systems and important crop or native plant species. Here, we test relationships between stomatal development and leaf physiology that have been established in model systems by sampling trees in a mature forest ecosystem. We found that plasticity in gsmax was limited throughout the canopy, despite other changes in leaf structure and function that are driven by environmental gradients in the canopy. However, the ratio between gs and gsmax was predictive of gas flux in the canopy and species-independent. Variation in the gs : gsmax ratio appeared to minimize the energy required to control aperture size via guard cell turgor pressure, thus compensating for the initial over-investment in stomatal production. gsmax also remained a strong predictor of photosynthetic potential and intrinsic water-use efficiency. The temporal relationship between gsmax and these functional leaf traits might depend on long-term adjustments in stomatal development, which was sensitive to increases in atmospheric CO2 in our study. The absence of a spatial response and the presence of a temporal response in stomatal development infers that multiple mechanisms may integrate environmental signaling in the developmental pathway. Collectively, this research helps to define the larger significance of the stomatal mechanisms being identified in model systems.

Structure-Property Relationships of Polymer Brushes in Restricted Geometries and their Utilization as Ultra-Low Lubricants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuhl, Tonya Lynn; Faller, Roland

2015-09-28

Though polymer films are widely used to modify or tailor the physical, chemical and mechanical properties of interfaces in both solid and liquid systems, the rational design of interface- or surface-active polymer modifiers has been hampered by a lack of information about the behavior and structure-property relationships of this class of molecules. This is especially true for systems in which the role of the polymer is to modify the interaction between two solid surfaces in intimate contact and under load, to cause them to be mechanically coupled (e.g. to promote adhesion and wetting) or to minimize their interaction (e.g. lubrication,more » colloidal stabilization, etc.). Detailed structural information on these systems has largely been precluded by the many difficulties and challenges associated with direct experimental measurements of polymer structure in these geometries. As a result, many practitioners have been forced to employ indirect measurements or rely wholly on theoretical modeling. This has resulted in an incomplete understanding of the structure-property relationships, which are relied upon for the rational design of improved polymer modifiers. Over the course of this current research program, we made direct measurements of the structure of polymers at the interface between two solid surfaces under confinement and elucidated the fundamental physics behind these phenomena using atomistic and coarse grained simulations. The research has potential to lead to new lubricants and wear reducing agents to improve efficiency.« less

Common evolutionary trends underlie the four-bar linkage systems of sunfish and mantis shrimp.

PubMed

Hu, Yinan; Nelson-Maney, Nathan; Anderson, Philip S L

2017-05-01

Comparative biomechanics offers an opportunity to explore the evolution of disparate biological systems that share common underlying mechanics. Four-bar linkage modeling has been applied to various biological systems such as fish jaws and crustacean appendages to explore the relationship between biomechanics and evolutionary diversification. Mechanical sensitivity states that the functional output of a mechanical system will show differential sensitivity to changes in specific morphological components. We document similar patterns of mechanical sensitivity in two disparate four-bar systems from different phyla: the opercular four-bar system in centrarchid fishes and the raptorial appendage of stomatopods. We built dynamic linkage models of 19 centrarchid and 36 stomatopod species and used phylogenetic generalized least squares regression (PGLS) to compare evolutionary shifts in linkage morphology and mechanical outputs derived from the models. In both systems, the kinematics of the four-bar mechanism show significant evolutionary correlation with the output link, while travel distance of the output arm is correlated with the coupler link. This common evolutionary pattern seen in both fish and crustacean taxa is a potential consequence of the mechanical principles underlying four-bar systems. Our results illustrate the potential influence of physical principles on morphological evolution across biological systems with different structures, behaviors, and ecologies. © 2017 The Author(s). Evolution © 2017 The Society for the Study of Evolution.

A climatology of potential severe convective environments across South Africa

NASA Astrophysics Data System (ADS)

Blamey, R. C.; Middleton, C.; Lennard, C.; Reason, C. J. C.

2017-09-01

Severe thunderstorms pose a considerable risk to society and the economy of South Africa during the austral summer months (October-March). Yet, the frequency and distribution of such severe storms is poorly understood, which partly stems out of an inadequate observation network. Given the lack of observations, alternative methods have focused on the relationship between severe storms and their associated environments. One such approach is to use a combination of covariant discriminants, derived from gridded datasets, as a probabilistic proxy for the development of severe storms. These covariates describe some key ingredient for severe convective storm development, such as the presence of instability. Using a combination of convective available potential energy and deep-layer vertical shear from Climate Forecast System Reanalysis, this study establishes a climatology of potential severe convective environments across South Africa for the period 1979-2010. Results indicate that early austral summer months are most likely associated with conditions that are conducive to the development of severe storms over the interior of South Africa. The east coast of the country is a hotspot for potential severe convective environments throughout the summer months. This is likely due to the close proximity of the Agulhas Current, which produces high latent heat fluxes and acts as a key moisture source. No obvious relationship is established between the frequency of potential severe convective environments and the main large-scale modes of variability in the Southern Hemisphere, such as ENSO. This implies that several factors, possibly more localised, may modulate the spatial and temporal frequency of severe thunderstorms across the region.

The Role of Interpersonal Comfort in Mentoring Relationships

ERIC Educational Resources Information Center

Allen, Tammy D.; Day, Rachel; Lentz, Elizabeth

2005-01-01

This research examined interpersonal comfort as a potential mediating mechanism in mentoring relationships. Results indicated that interpersonal comfort mediated the relationship between gender similarity and protege reports of career and psychosocial mentoring. Contrary to prediction, interpersonal comfort did not mediate relationships involving…

Introduced Species, Disease Ecology, and Biodiversity-Disease Relationships.

PubMed

Young, Hillary S; Parker, Ingrid M; Gilbert, Gregory S; Sofia Guerra, Ana; Nunn, Charles L

2017-01-01

Species introductions are a dominant component of biodiversity change but are not explicitly included in most discussions of biodiversity-disease relationships. This is a major oversight given the multitude of effects that introduced species have on both parasitism and native hosts. Drawing on both animal and plant systems, we review the competing mechanistic pathways by which biological introductions influence parasite diversity and prevalence. While some mechanisms - such as local changes in phylogenetic composition and global homogenization - have strong explanatory potential, the net effects of introduced species, especially at local scales, remain poorly understood. Integrative, community-scale studies that explicitly incorporate introduced species are needed to make effective predictions about the effects of realistic biodiversity change and conservation action on disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Price-Concentration Relationship in Early Residential Solar Third-Party Markets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pless, Jacquelyn; Langheim, Ria; Machak, Christina

The market for residential solar photovoltaic (PV) systems in the United States has experienced tremendous growth over the past decade, with installed capacity more than doubling between 2014 and 2016 alone (SEIA, 2016). As the residential market continues to grow, it prompts new questions about the nature of competition between solar installers and how this competition, or lack thereof, affects the prices consumers are paying. It is often assumed that more competition leads to lower prices, but this is not universally true. For example, some studies have shown that factors such as brand loyalty could lead to a negative relationshipmore » between concentration and price in imperfectly competitive markets (Borenstein, 1985; Holmes, 1989). As such, the relationship between prices and market concentration is an open empirical question since theory could predict either a positive or negative relationship. Determining a relationship between prices and market concentration is challenging for several reasons. Most significantly, prices and market structure are simultaneously determined by each other -- the amount of competition a seller faces influences the price they can command, and prices determine a seller's market share. Previous studies have examined recent PV pricing trends over time and between markets (Davidson et al., 2015a; Davidson and Margolis 2015b; Nemet et al., 2016; Gillingham et al., 2014; Barbose and Darghouth 2015). While these studies of solar PV pricing are able to determine correlations between prices and market factors, they have not satisfactorily proven causation. Thus, to the best of our knowledge, there is little work to date that focuses on identifying the causal relationship between market structure and the prices paid by consumers. We use a unique dataset on third-party owned contract terms for the residential solar PV market in the San Diego Gas and Electricity service territory to better understand this relationship. Surprisingly, we find that firms charged higher prices in more competitive markets in our sample. The finding is robust across multiple definitions of firm concentration. There are at least two potential explanations for our findings. First, firms could be conducting entry deterrence strategies. It is possible that firms are acting in a non-competitive way and setting prices lower than they would be otherwise. Setting low prices that are below potential competitors' marginal costs could deter entrants and ensure a larger market share. Second, there could be a group of dominant firms (with a competitive fringe), and the dominant firms may occasionally engage in price wars. If this is true, prices should be lower in more concentrated markets during the price wars (Salinger, 1990). As the rooftop PV market continues to grow, market structure will remain a relevant policy issue in consideration of the potential for rooftop solar to contribute to de-carbonization efforts or other policy objectives. This paper adds to a growing emphasis on understanding supply-side factors in scaling up solar markets in the residential sector. Generally, solar markets have become more competitive over the same time period that solar technology costs decreased. While solar system hard costs have come down, our research suggests that total costs are more nuanced in early solar system TPO markets. Policymakers should consider these findings when designing markets, and have the data needed to make informed decisions.« less

Area Disadvantage and Intimate Partner Homicide: An Ecological Analysis of North Carolina Counties, 2004–2006

PubMed Central

Madkour, Aubrey Spriggs; Martin, Sandra L.; Halpern, Carolyn Tucker; Schoenbach, Victor J.

2009-01-01

Using data from the North Carolina Violent Death Reporting System and other sources, we examined ecologic relationships between county (n=100) disadvantage and intimate partner homicide (IPH), variability by victim gender and county urbanicity, and potential mediators. County disadvantage was related to female-victim homicide only in metropolitan counties (incidence rate ratio [IRR] 1.25); however, disadvantage was associated with male-victim IPH regardless of county urbanicity (IRR 1.17). None of the potential intervening variables examined (shelter availability, intimate partner violence services’ funding), was supported as a mediator. Results suggest disparities across North Carolina counties in IPH according to county disadvantage. Future research should explore other potential mediators (i.e., service accessibility and law enforcement responses), as well as test the robustness of findings using additional years of data. PMID:20565007

Listeria Occurrence in Poultry Flocks: Detection and Potential Implications.

PubMed

Rothrock, Michael J; Davis, Morgan L; Locatelli, Aude; Bodie, Aaron; McIntosh, Tori G; Donaldson, Janet R; Ricke, Steven C

2017-01-01

Foodborne pathogens such as Salmonella, Campylobacter, Escherichia coli , and Listeria are a major concern within the food industry due to their pathogenic potential to cause infection. Of these, Listeria monocytogenes , possesses a high mortality rate (approximately 20%) and is considered one of the most dangerous foodborne pathogens. Although the usual reservoirs for Listeria transmission have been extensively studied, little is known about the relationship between Listeria and live poultry production. Sporadic and isolated cases of listeriosis have been attributed to poultry production and Listeria spp. have been isolated from all stages of poultry production and processing. Farm studies suggest that live birds may be an important vector and contributor to contamination of the processing environment and transmission of Listeria to consumers. Therefore, the purpose of this review is to highlight the occurrence, incidence, and potential systemic interactions of Listeria spp. with poultry.

[Data protection. Barrier or helpful orientation for cooperation in early intervention?].

PubMed

Schönecker, L; Meysen, T

2010-11-01

From birth until the age of 3 years, the health care system is the central help system and point of contact for parents with their children. Professionals in health care are given considerable trust. However, many of the essential services, especially for families with increased needs, can only be found in the child welfare system. The authors describe a plan for a lawful and functionally adequate transition between the two systems that eases access to additional help. Functional data protection secures a relationship of trust between the doctor and patient. It requires the promotion of a consensual transition. If the transmission of information is necessary, not without the knowledge but without the consent of the parents, the law permits the transfer of information under certain conditions. For doctors, midwifes, pediatric nurses, and other health professionals, this results in a legal examination program with respect to the supporting relationship to their patient. On the one hand, it contains an assessment of the child's endangerment and, on the other hand, an estimation of the sustainability of the assistance they entered into for the prevention of further harm or the solicitation of voluntary utilization of additional help. The article introduces the different new federal state laws on data transfer without consent in cases of potential child endangerment.

Molnets: An Artificial Chemistry Based on Neural Networks

NASA Technical Reports Server (NTRS)

Colombano, Silvano; Luk, Johnny; Segovia-Juarez, Jose L.; Lohn, Jason; Clancy, Daniel (Technical Monitor)

2002-01-01

The fundamental problem in the evolution of matter is to understand how structure-function relationships are formed and increase in complexity from the molecular level all the way to a genetic system. We have created a system where structure-function relationships arise naturally and without the need of ad hoc function assignments to given structures. The idea was inspired by neural networks, where the structure of the net embodies specific computational properties. In this system networks interact with other networks to create connections between the inputs of one net and the outputs of another. The newly created net then recomputes its own synaptic weights, based on anti-hebbian rules. As a result some connections may be cut, and multiple nets can emerge as products of a 'reaction'. The idea is to study emergent reaction behaviors, based on simple rules that constitute a pseudophysics of the system. These simple rules are parameterized to produce behaviors that emulate chemical reactions. We find that these simple rules show a gradual increase in the size and complexity of molecules. We have been building a virtual artificial chemistry laboratory for discovering interesting reactions and for testing further ideas on the evolution of primitive molecules. Some of these ideas include the potential effect of membranes and selective diffusion according to molecular size.

A Robust Feedforward Model of the Olfactory System

NASA Astrophysics Data System (ADS)

Zhang, Yilun; Sharpee, Tatyana

Most natural odors have sparse molecular composition. This makes the principles of compressing sensing potentially relevant to the structure of the olfactory code. Yet, the largely feedforward organization of the olfactory system precludes reconstruction using standard compressed sensing algorithms. To resolve this problem, recent theoretical work has proposed that signal reconstruction could take place as a result of a low dimensional dynamical system converging to one of its attractor states. The dynamical aspects of optimization, however, would slow down odor recognition and were also found to be susceptible to noise. Here we describe a feedforward model of the olfactory system that achieves both strong compression and fast reconstruction that is also robust to noise. A key feature of the proposed model is a specific relationship between how odors are represented at the glomeruli stage, which corresponds to a compression, and the connections from glomeruli to Kenyon cells, which in the model corresponds to reconstruction. We show that provided this specific relationship holds true, the reconstruction will be both fast and robust to noise, and in particular to failure of glomeruli. The predicted connectivity rate from glomeruli to the Kenyon cells can be tested experimentally. This research was supported by James S. McDonnell Foundation, NSF CAREER award IIS-1254123, NSF Ideas Lab Collaborative Research IOS 1556388.

Fingerprints of transverse and longitudinal coupling between induced open quantum dots in the longitudinal magnetoconductance through antidot lattices

NASA Astrophysics Data System (ADS)

Ujevic, Sebastian; Mendoza, Michel

2010-07-01

We propose numerical simulations of longitudinal magnetoconductance through a finite antidot lattice located inside an open quantum dot with a magnetic field applied perpendicular to the plane. The system is connected to reservoirs using quantum point contacts. We discuss the relationship between the longitudinal magnetoconductance and the generation of transversal couplings between the induced open quantum dots in the system. The system presents longitudinal magnetoconductance maps with crossovers (between transversal bands) and closings (longitudinal decoupling) of fundamental quantum states related to the open quantum dots induced by the antidot lattice. A relationship is observed between the distribution of antidots and the formed conductance bands, allowing a systematic follow up of the bands as a function of the applied magnetic field and quantum point-contact width. We observed a high conductance intensity [between n and (n+1) quantum of conductance, n=1,2,… ] in the regions of crossover and closing of states. This suggests transversal couplings between the induced open quantum dots of the system that can be modulated by varying both the antidots potential and the quantum point-contact width. A new continuous channel (not expected) is induced by the variation in the contact width and generate Fano resonances in the conductance. These resonances can be manipulated by the applied magnetic field.

Moments of real relationship in psychoanalytic supervision.

PubMed

Watkins, C Edward

2012-09-01

What role does the real relationship play in psychoanalytic supervision? While the real relationship's role has long been and continues to be considered with regard to psychoanalysis, it has received virtually no attention in the supervision literature. In this paper, using Horney's construct of the real self as conceptual anchor, I attempt to: (1) situate the real relationship squarely within the borders of the psychoanalytic supervision relationship; (2) examine the relevance of real relationship phenomena for the supervision experience; (3) provide some simple, ordinary yet meaningful examples of case dialogue that illustrate moments of real relationship in supervision; and (4) introduce the concept of real relationship rupture and consider its potential ramifications for and impact upon the supervisor-supervisee relationship. Just as ruptures can occur in the supervisory alliance, I propose that ruptures can also transpire in the supervisory real relationship, have the potential to reverberate throughout the entirety of the supervision experience, and depending upon how they are handled, can prove either constructive and relationally energizing and enlivening or enervating and eviscerating to supervision process and outcome.

Pesticides and Parkinson’s Disease—Is There a Link?

PubMed Central

Brown, Terry P.; Rumsby, Paul C.; Capleton, Alexander C.; Rushton, Lesley; Levy, Leonard S.

2006-01-01

Parkinson’s disease (PD) is an idiopathic disease of the nervous system characterized by progressive tremor, bradykinesia, rigidity, and postural instability. It has been postulated that exogenous toxicants, including pesticides, might be involved in the etiology of PD. In this article we present a comprehensive review of the published epidemiologic and toxicologic literature and critically evaluate whether a relationship exists between pesticide exposure and PD. From the epidemiologic literature, there does appear to be a relatively consistent relationship between pesticide exposure and PD. This relationship appears strongest for exposure to herbicides and insecticides, and after long durations of exposure. Toxicologic data suggest that paraquat and rotenone may have neurotoxic actions that potentially play a role in the development of PD, with limited data for other pesticides. However, both the epidemiology and toxicology studies were limited by methodologic weaknesses. Particular issues of current and future interest include multiple exposures (both pesticides and other exogenous toxicants), developmental exposures, and gene–environment interactions. At present, the weight of evidence is sufficient to conclude that a generic association between pesticide exposure and PD exists but is insufficient for concluding that this is a causal relationship or that such a relationship exists for any particular pesticide compound or combined pesticide and other exogenous toxicant exposure. PMID:16451848

Adolescent cancer patients' perceived quality of cancer care: The roles of patient engagement and supporting independence.

PubMed

Siembida, Elizabeth J; Kadan-Lottick, Nina S; Moss, Kerry; Bellizzi, Keith M

2018-04-10

A lack of focus on variation in engagement among cancer populations of differing developmental stages led us to examine the associations between patient engagement, the patient-provider relationship, cognitive development, readiness to transition to adulthood (transitional readiness) and perceived quality of care. A sample of 101 adolescent cancer patients (diagnosed 10-20 years) completed survey items concerning patient engagement, dimensions of the patient-provider relationship, cognitive development, transitional readiness, and demographic characteristics using an iPad/tablet during a routine clinic visit. Patient engagement was not significantly associated with perceived quality of care (b = .02, 95% CI: -0.06, 0.11). Instead, adolescents with providers that supported their independence (b = .34, 95% CI: 0.17, 0.52) were significantly more likely to perceive higher quality care. Supportive patient-provider relationships are an integral part of adolescents' perceptions of quality of care. Adolescents are still gaining important skills for navigating the medical system, and the patient-provider relationship may provide an important scaffolding relationship to help adolescents build independence in their treatment experience. Identifying potential mechanisms through which adolescents can provide their opinion, ask questions, and participate in their treatment plan will help in supporting adolescent independence and improve quality of care. Published by Elsevier B.V.

How well do general practitioners and hospital consultants work together? A qualitative study of cooperation and conflict within the medical profession.

PubMed Central

Marshall, M N

1998-01-01

BACKGROUND: The professional relationship between general practitioners (GPs) and hospital consultants (sometimes referred to as 'specialists') is important in a health care system based upon the generalist as the first point of contact for patients and the gatekeeper for hospital services. This relationship has been the subject of considerable interest over the years, but little empirical research has been carried out. AIM: To investigate the professional relationship in terms of the balance between cooperation and conflict between GPs and specialists in clinical contact. METHOD: A qualitative study using 24 semistructured interviews and four focus group interviews with a purposeful sample of clinicians working in the south-west of England. A content analysis of the data was performed. RESULTS: There is a high level of mutual respect and cooperation between the two branches of the profession and a strong desire to build a personal relationship over a long period of time. There are few areas of significant disagreement; indeed, most members of both branches of the profession try hard to deal with, or avoid, potential conflict. CONCLUSION: The professional relationship between GPs and specialists is better than the literature and anecdotal stories might suggest. PMID:9800393

Mental Health and School Functioning for Girls in the Child Welfare System: the Mediating Role of Future Orientation and School Engagement.

PubMed

Threlfall, Jennifer M; Auslander, Wendy; Gerke, Donald; McGinnis, Hollee; Myers Tlapek, Sarah

2017-01-01

This study investigated the association between mental health problems and academic and behavioral school functioning for adolescent girls in the child welfare system and determined whether school engagement and future orientation meditated the relationship. Participants were 231 girls aged between 12 and 19 who had been involved with the child welfare system. Results indicated that 39% of girls reported depressive symptoms in the clinical range and 54% reported posttraumatic symptoms in the clinical range. The most common school functioning problems reported were failing a class (41%) and physical fights with other students (35%). Participants reported a mean number of 1.7 school functioning problems. Higher levels of depression and PTSD were significantly associated with more school functioning problems. School engagement fully mediated the relationship between depression and school functioning and between PTSD and school functioning, both models controlling for age, race, and placement stability. Future orientation was not significantly associated with school functioning problems at the bivariate level. Findings suggest that school engagement is a potentially modifiable target for interventions aiming to ameliorate the negative influence of mental health problems on school functioning for adolescent girls with histories of abuse or neglect.

The dynamic relationships between economic status and health measures among working-age adults in the United States.

PubMed

Meraya, Abdulkarim M; Dwibedi, Nilanjana; Tan, Xi; Innes, Kim; Mitra, Sophie; Sambamoorthi, Usha

2018-04-18

We examine the dynamic relationships between economic status and health measures using data from 8 waves of the Panel Study of Income Dynamics from 1999 to 2013. Health measures are self-rated health (SRH) and functional limitations; economic status measures are labor income (earnings), family income, and net wealth. We use 3 different types of models: (a) ordinary least squares regression, (b) first-difference, and (c) system-generalized method of moment (GMM). Using ordinary least squares regression and first difference models, we find that higher levels of economic status are associated with better SRH and functional status among both men and women, although declines in income and wealth are associated with a decline in health for men only. Using system-GMM estimators, we find evidence of a causal link from labor income to SRH and functional status for both genders. Among men only, system-GMM results indicate that there is a causal link from net wealth to SRH and functional status. Results overall highlight the need for integrated economic and health policies, and for policies that mitigate the potential adverse health effects of short-term changes in economic status. Copyright © 2018 John Wiley & Sons, Ltd.

Automatic Non-Destructive Growth Measurement of Leafy Vegetables Based on Kinect

PubMed Central

Hu, Yang; Wang, Le; Xiang, Lirong; Wu, Qian; Jiang, Huanyu

2018-01-01

Non-destructive plant growth measurement is essential for plant growth and health research. As a 3D sensor, Kinect v2 has huge potentials in agriculture applications, benefited from its low price and strong robustness. The paper proposes a Kinect-based automatic system for non-destructive growth measurement of leafy vegetables. The system used a turntable to acquire multi-view point clouds of the measured plant. Then a series of suitable algorithms were applied to obtain a fine 3D reconstruction for the plant, while measuring the key growth parameters including relative/absolute height, total/projected leaf area and volume. In experiment, 63 pots of lettuce in different growth stages were measured. The result shows that the Kinect-measured height and projected area have fine linear relationship with reference measurements. While the measured total area and volume both follow power law distributions with reference data. All these data have shown good fitting goodness (R2 = 0.9457–0.9914). In the study of biomass correlations, the Kinect-measured volume was found to have a good power law relationship (R2 = 0.9281) with fresh weight. In addition, the system practicality was validated by performance and robustness analysis. PMID:29518958

Changing roles for primary-care physicians: addressing challenges and opportunities.

PubMed

McLaughlin, C P; Kaluzny, A D; Kibbe, D C; Tredway, R

2005-01-01

Direct-to-consumer advertising is but one example of a process called disintermediation that is directly affecting primary-care physicians and their patients. This paper examines the trends and the actors involved in disintermediation, which threatens the traditional patient-physician relationship. The paper outlines the social forces behind these threats and illustrates the resulting challenges and opportunities. A rationale and strategies are presented to rebuild, maintain and strengthen the patient-physician relationship in an era of growing disintermediation and anticipated advancements in cost-effective office-based information systems. Primary care--as we know it--is under siege from a number of trends in healthcare delivery, resulting in loss of physician autonomy, disrupted continuity of care and potential erosion of professional values (Rastegar 2004; Future of Family Medicine Project Leadership Committee 2004). The halcyon days of medicine as a craft guild with a monopoly on (1) technical knowledge and (2) the means of implementation, reached its zenith in the mid-twentieth century and has been under pressure ever since (Starr 1982; Schlesinger 2002). While this is a trend within the US health system, it is likely to affect other delivery systems in the years ahead.

The link between hypomania risk and creativity: The role of heightened behavioral activation system (BAS) sensitivity.

PubMed

Kim, Bin-Na; Kwon, Seok-Man

2017-06-01

The relationship between bipolar disorder (BD) and creativity is well-known; however, relatively little is known about its potential mechanism. We investigated whether heightened behavioral activation system (BAS) sensitivity may mediate such relationship. Korean young adults (N=543) completed self-report questionnaires that included the Hypomanic Personality Scale (HPS), the Behavioral Activation System(BAS) Scale, the Everyday Creativity Scale (ECS), the Positive Affect and Negative Affect Schedule (PANAS), and the Altman Self-Rating Mania Scale (ASRM). Correlational, hierarchical regression and mediation analyses using bootstrap confidence intervals were conducted. As predicted, BAS sensitivity was associated with self-reported creativity as well as hypomania risk and symptoms. Even when positive affect was controlled, BAS sensitivity predicted incrementally significant variance in explaining creativity. In mediation analysis, BAS sensitivity partially mediated the relation between hypomania risk and creativity. Reliance on self-report measures in assessing creativity and usage of non-clinical sample. BAS sensitivity was related not only to mood pathology but also to creativity. As a basic affective temperament, BAS sensitivity may help explain incompatible sides of adaptation associated with BD. Copyright © 2017 Elsevier B.V. All rights reserved.

Vestibular evoked myogenic potentials in patients with ankylosing spondylitis.

PubMed

Özgür, Abdulkadir; Serdaroğlu Beyazal, Münevver; Terzi, Suat; Coşkun, Zerrin Özergin; Dursun, Engin

2016-10-01

Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease with unknown etiology. Although sacroiliac joint involvement is the classic sign along with the formed immune mediators, it may result in immune-mediated inner ear disease and may cause damage to the audiovestibular system. Vestibular evoked myogenic potentials (VEMP) is a clinical reflex test used in the diagnosis of vestibular diseases and is performed by recording and evaluating the muscle potentials resulting from the stimulation of the vestibular system with different stimuli. The aim of this study is to evaluate the cervical VEMP test results in AS patients without vestibular symptoms. Thirty-three patients with AS and a control group of 30 healthy volunteers with similar demographic characteristics were evaluated in the study. VEMP wave latency, P13-N23 wave amplitude, and VEMP asymmetry ratio (VAR) values were compared between the groups. The relationship between clinical and laboratory findings of the AS patients and VEMP data were also investigated. Compared with healthy people, this study shows the response rate of patients with ankylosing spondylitis was reduced in the VEMP test, and P13-N23 wave amplitude showed a decrease in AS patients who had VEMP response (p < 0.001). There was no correlation between the clinical and laboratory findings and VEMP findings in patients with ankylosing spondylitis. The data obtained from this study suggest that AS may lead to decreased sensitivity of the vestibular system.

Boredom in the Workplace: A New Look at an Old Problem.

PubMed

Cummings, Mary L; Gao, Fei; Thornburg, Kris M

2016-03-01

We review historical and more recent efforts in boredom research and related fields. A framework is presented that organizes the various facets of boredom, particularly in supervisory control settings, and research gaps and future potential areas for study are highlighted. Given the ubiquity of boredom across a wide spectrum of work environments--exacerbated by increasingly automated systems that remove humans from direct, physical system interaction and possibly increasing tedium in the workplace--there is a need not only to better understand the multiple facets of boredom in work environments but to develop targeted mitigation strategies. To better understand the relationships between the various influences and outcomes of boredom, a systems-based framework, called the Boredom Influence Diagram, is proposed that describes various elements of boredom and their interrelationships. Boredom is closely related to vigilance, attention management, and task performance. This review highlights the need to develop more naturalistic experiments that reflect the characteristics of a boring work environment. With the increase in automation, boredom in the workplace will likely become a more prevalent issue for motivation and retention. In addition, developing continuous measures of boredom based on physiological signals is critical. Personnel selection and improvements in system and task design can potentially mitigate boredom. However, more work is needed to develop and evaluate other potential interventions. © 2015, Human Factors and Ergonomics Society.

A bottom-up approach to identifying the maximum operational adaptive capacity of water resource systems to a changing climate

NASA Astrophysics Data System (ADS)

Culley, S.; Noble, S.; Yates, A.; Timbs, M.; Westra, S.; Maier, H. R.; Giuliani, M.; Castelletti, A.

2016-09-01

Many water resource systems have been designed assuming that the statistical characteristics of future inflows are similar to those of the historical record. This assumption is no longer valid due to large-scale changes in the global climate, potentially causing declines in water resource system performance, or even complete system failure. Upgrading system infrastructure to cope with climate change can require substantial financial outlay, so it might be preferable to optimize existing system performance when possible. This paper builds on decision scaling theory by proposing a bottom-up approach to designing optimal feedback control policies for a water system exposed to a changing climate. This approach not only describes optimal operational policies for a range of potential climatic changes but also enables an assessment of a system's upper limit of its operational adaptive capacity, beyond which upgrades to infrastructure become unavoidable. The approach is illustrated using the Lake Como system in Northern Italy—a regulated system with a complex relationship between climate and system performance. By optimizing system operation under different hydrometeorological states, it is shown that the system can continue to meet its minimum performance requirements for more than three times as many states as it can under current operations. Importantly, a single management policy, no matter how robust, cannot fully utilize existing infrastructure as effectively as an ensemble of flexible management policies that are updated as the climate changes.

An Epidemiological Network Model for Disease Outbreak Detection

PubMed Central

Reis, Ben Y; Kohane, Isaac S; Mandl, Kenneth D

2007-01-01

Background Advanced disease-surveillance systems have been deployed worldwide to provide early detection of infectious disease outbreaks and bioterrorist attacks. New methods that improve the overall detection capabilities of these systems can have a broad practical impact. Furthermore, most current generation surveillance systems are vulnerable to dramatic and unpredictable shifts in the health-care data that they monitor. These shifts can occur during major public events, such as the Olympics, as a result of population surges and public closures. Shifts can also occur during epidemics and pandemics as a result of quarantines, the worried-well flooding emergency departments or, conversely, the public staying away from hospitals for fear of nosocomial infection. Most surveillance systems are not robust to such shifts in health-care utilization, either because they do not adjust baselines and alert-thresholds to new utilization levels, or because the utilization shifts themselves may trigger an alarm. As a result, public-health crises and major public events threaten to undermine health-surveillance systems at the very times they are needed most. Methods and Findings To address this challenge, we introduce a class of epidemiological network models that monitor the relationships among different health-care data streams instead of monitoring the data streams themselves. By extracting the extra information present in the relationships between the data streams, these models have the potential to improve the detection capabilities of a system. Furthermore, the models' relational nature has the potential to increase a system's robustness to unpredictable baseline shifts. We implemented these models and evaluated their effectiveness using historical emergency department data from five hospitals in a single metropolitan area, recorded over a period of 4.5 y by the Automated Epidemiological Geotemporal Integrated Surveillance real-time public health–surveillance system, developed by the Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology on behalf of the Massachusetts Department of Public Health. We performed experiments with semi-synthetic outbreaks of different magnitudes and simulated baseline shifts of different types and magnitudes. The results show that the network models provide better detection of localized outbreaks, and greater robustness to unpredictable shifts than a reference time-series modeling approach. Conclusions The integrated network models of epidemiological data streams and their interrelationships have the potential to improve current surveillance efforts, providing better localized outbreak detection under normal circumstances, as well as more robust performance in the face of shifts in health-care utilization during epidemics and major public events. PMID:17593895

Mechanisms and implications of a type IV functional response for short-term intake rate of dry matter in large mammalian herbivores.

PubMed

Mezzalira, Jean C; Bonnet, Olivier J F; Carvalho, Paulo C de F; Fonseca, Lidiane; Bremm, Carolina; Mezzalira, Carlos C; Laca, Emilio A

2017-09-01

The functional response (i.e. the relationship between consumers' intake rate and resource density) is central in plant-herbivore interactions. Its shape and the biological processes leading to it have significant implications for both foraging theory and ecology of grazing systems. A type IV functional response (i.e. dome-shaped relationship) of short-term intake rate of dry matter (intake while grazing) has rarely been reported for large herbivores and the conditions that can lead to it are poorly understood. We report a type IV functional response observed in heifers grazing monocultures of Cynodon sp. and Avena strigosa. The mechanisms and consequences of this type of functional response for grazed system dynamics are discussed. Intake rate was higher at intermediate than at short or tall sward heights in both grass species. The type IV functional response resulted from changes in bite mass instead of a longer time needed to encounter and process bites. Thus, the decrease of intake rate of dry matter in tall swards is not explained by a shift from process 3 (potential bites are concentrated and apparent) to process 2 (potential bites are apparent but dispersed, Spalinger & Hobbs 1992). Bite mass was smaller in tall than in intermediate swards due to a reduction of bite volume possibly caused by the greater proportion of stem and sheath acting as a physical barrier to bite formation. It is generally accepted that potential bites are abundant and apparent in most grassland and meadow systems, as they were in the present experiments. Therefore, a type IV response of intake rate not directly related to digestive constraints may determine the dynamics of intake and defoliation under a much larger set of conditions than previously thought. These results have implications for foraging theory and stability of grazing systems. For example, if animals prefer patches of intermediate stature that yield the highest intake rate, grazing should lead to the widely observed bimodal distribution of plant mass per unit area, even when tall patches are not of significantly lower digestive quality than the pasture average. © 2017 The Authors. Journal of Animal Ecology © 2017 British Ecological Society.

An Interdisciplinary Meta-Analysis of the Potential Antecedents, Correlates, and Consequences of Protege Perceptions of Mentoring

ERIC Educational Resources Information Center

Eby, Lillian Turner de Tormes; Allen, Tammy D.; Hoffman, Brian J.; Baranik, Lisa E.; Sauer, Julia B.; Baldwin, Sean; Morrison, M. Ashley; Kinkade, Katie M.; Maher, Charleen P.; Curtis, Sara; Evans, Sarah C.

2013-01-01

This meta-analysis summarized youth, academic, and workplace research on the potential antecedents (demographics, human capital, and relationship attributes), correlates (interaction frequency, relationship length, performance, motivation, and social capital), and consequences (attitudinal, behavioral, career-related, and health-related outcomes)…

Multicultural Issues in Graduate Advising Relationships

ERIC Educational Resources Information Center

Schlosser, Lewis Z.; Talleyrand, Regine M.; Lyons, Heather Z.; Kim, Bryan S. K.; Johnson, W. Brad

2011-01-01

Although advisor-advisee relationships are ubiquitous to graduate training, there is relatively little scholarship bearing on advising relationships. Not surprisingly, the intersection between multiculturalism and advising relationships is also sparse. Given the potential increase in the numbers of People of Color entering graduate training due to…

[RELATIONSHIP BETWEEN THE PREVALENCE OF CHRONIC NONINFECTIOUS DISEASES AND ELECTROPHYSICAL STATE OF THE ENVIRONMENT].

PubMed

Rakhmanin, Yu A; Stekhin, A A; Yakovleva, G V; Karasev, A K; Marasanov, A V; Iksanova, T I; Ryabikov, V V

2015-01-01

In the paper there is evaluated the relationship of features of electronic state of the environment with a level of chronic, noninfectious diseases (CNID) in the regions of Russia, obtained on the basis of the monitoring measurements of the intensity of natural background electronic Bose condensate (BEBC) of natural ecosystems in a number of Russian regions and seas of the Arctic Ocean. The assessment of BEBC was implemented on results of measurements of redox state of distilled water being in the contact with natural water. The equilibrium redox state of distilled water, determined by the influx of electrons (quantum reduction) outside, is proportional to the intensity of BEBC. The obtained data attest to an increase in the intensity of the background of EBC in Siberia regions and, especially, within the limits ofwaters of Lake Baikal (the redox potential of the surface water in the lake ~ -70mV). Also there is observed a strong dependence of the background EBC in the latitudinal direction. Low levels of background EBC were noted in the Arkhangelsk region and the north-eastern Chukotka. Functioning of international systems of plasma sounding of ionosphere (such systems as HAARP) were established to have a detrimental effect on the background EBC in these regions. According to the results of measurements of the relative values of intensities of natural background of Bose condensate of electrons there was constructed the dependence reflecting the relationship of the prevalence of noninfectious diseases in the regions of Russia with the redox state of distilled water which can be characterized as a significant (regression coefficient R2 = 0.78). The relationship between noninfectious diseases (NID, %) with the intensity of the background of EBC (Ib rel. units) is estimated by the equation: NID [%] = 0.24Eh [mV]-25, where Eh ~ I/Ib. Numerical evaluations show that an increase in the biosphere redox potential of water by 90mV leads to an increase of the primary incidence by 20% (relatively to the average values for Russia). Analysis of results attests to the relationship of CNID with the electrophysical state of the environment that allows from different positions to arrive to true causes of their emergence, associated with changes in the electrophysical conditions of habitation and human activities that lead to the nascency of cellular metabolic disturbances.

Protoplast Volume:Water Potential Relationship and Bound Water Fraction in Spinach Leaves 1

PubMed Central

Santakumari, Mane; Berkowitz, Gerald A.

1989-01-01

Methods used to estimate the (nonosmotic) bound water fraction (BWF) (i.e. apoplast water) of spinach (Spinacia oleracea L.) leaves were evaluated. Studies using three different methods of pressure/volume (P/V) curve construction all resulted in a similar calculation of BWF; approximately 40%. The theoretically derived BWF, and the water potential (Ψw)/relative water content relationship established from P/V curves were used to establish the relationship between protoplast (i.e. symplast) volume and Ψw. Another method of establishing the protoplast volume/Ψw relationship in spinach leaves was compared with the results from P/V curve experiments. This second technique involved the vacuum infiltration of solutions at a range of osmotic potentials into discs cut from spinach leaves. These solutions contained radioactively labeled H2O and sorbitol. This dual label infiltration technique allowed for simultaneous measurement of the total and apoplast volumes in leaf tissue; the difference yielded the protoplast volume. The dual label infiltration experiments and the P/V curve constructions both showed that below −1 megapascals, protoplast volume decreases sharply with decreasing water potential; with 50% reduction in protoplast volume occurring at −1.8 megapascals leaf water potential. PMID:16666983

Managing Reputation in Contract-Based Distributed Systems

NASA Astrophysics Data System (ADS)

Baldoni, Roberto; Doria, Luca; Lodi, Giorgia; Querzoni, Leonardo

In industry practice, bilateral agreements are established between providers and consumers of services in order to regulate their business relationships. In particular, Quality of Service (QoS) requirements are specified in those agreements in the form of legally binding contracts named Service Level Agreements (SLA). Meeting SLAs allows providers to be seen in the eyes of their clients, credible, reliable, and trustworthy. This contributes to augment their reputation that can be considered an important and competitive advantage for creating potentially new business opportunities.

Porous Hydroxyapatite Scaffold with Three-Dimensional Localized Drug Delivery System Using Biodegradable Microspheres

DTIC Science & Technology

2011-03-21

produced were also labeled with FITC using a modification of a previously described technique [22]. PEI- coated microsphere (30 mg/mL) were mixed with...surface after 4 h of mixing (Fig. 5A), while PEI-coated microspheres were well- dispersed and immobilized onto the HAp surface (Fig. 5B). 3.3. Properties of...Erickson, L. Ren, D. Li, Zeta-potential measurement using the smoluchowski equation and the slope of the current-time relationship in electroosmotic flow

A Psychodynamic Systems Perspective on Command Relationship during Combat Operations

DTIC Science & Technology

2017-06-09

that theirs is a high likelihood of conflicts when leaders fail to act as a boundary regulator. Failing to act as a boundary regulator, affects the...healthy command climate based on mission command.2 However, leaders do not always succeed in this task, and when they fail it, can have severe... when a leader fails to fulfill his role as a boundary regulator, there is a marked potential for conflict, as was highlighted with the case where the

Relationships between water, otolith, and scale chemistries of westslope cutthroat trout from the Coeur d'Alene River, Idaho: the potential application of hard-part chemistry to describe movements in freshwater

Treesearch

Brian K. Wells; Bruce E. Rieman; James L. Clayton; Donna L. Horan; Cynthia M. Jones

2003-01-01

We quantified Mg:Ca, Mn:Ca, Sr:Ca, and Ba:Ca molar ratios from an area representing the summer 2000 growth season on otoliths and scales from 1-year-old westslope cutthroat trout Oncorhyncus clarki lewisi collected from three streams in the Coeur d'Alene River, Idaho, system. We also quantified Mg:Ca, Sr:Ca, and Ba:Ca molar ratios in the water...

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

PubMed Central

Sayer, James R.; Walldén, Karin; Pesnot, Thomas; Campbell, Frederick; Gane, Paul J.; Simone, Michela; Koss, Hans; Buelens, Floris; Boyle, Timothy P.; Selwood, David L.; Waksman, Gabriel; Tabor, Alethea B.

2014-01-01

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure–activity relationships of these inhibitors, which show potential as antibacterial agents. PMID:25438770

Identification of iron and heme utilization genes in Aeromonas and their role in the colonization of the leech digestive tract

PubMed Central

Maltz, Michele; LeVarge, Barbara L.; Graf, Joerg

2015-01-01

It is known that many pathogens produce high-affinity iron uptake systems like siderophores and/or proteins for utilizing iron bound to heme-containing molecules, which facilitate iron-acquisition inside a host. In mutualistic digestive-tract associations, iron uptake systems have not been as well studied. We investigated the importance of two iron utilization systems within the beneficial digestive-tract association Aeromonas veronii and the medicinal leech, Hirudo verbana. Siderophores were detected in A. veronii using chrome azurol S. Using a mini Tn5, a transposon insertion in viuB generated a mutant unable to utilize iron using siderophores. The A. veronii genome was then searched for genes potentially involved in iron utilization bound to heme-containing molecules. A putative outer membrane heme receptor (hgpB) was identified with a transcriptional activator, termed hgpR, downstream. The hgpB gene was interrupted with an antibiotic resistance cassette in both the parent strain and the viuB mutant, yielding an hgpB mutant and a mutant with both iron uptake systems inactivated. In vitro assays indicated that hgpB is involved in utilizing iron bound to heme and that both iron utilization systems are important for A. veronii to grow in blood. In vivo colonization assays revealed that the ability to acquire iron from heme-containing molecules is critical for A. veronii to colonize the leech gut. Since iron and specifically heme utilization is important in this mutualistic relationship and has a potential role in virulence factor of other organisms, genomes from different Aeromonas strains (both clinical and environmental) were queried with iron utilization genes of A. veronii. This analysis revealed that in contrast to the siderophore utilization genes heme utilization genes are widely distributed among aeromonads. The importance of heme utilization in the colonization of the leech further confirms that symbiotic and pathogenic relationships possess similar mechanisms for interacting with animal hosts. PMID:26284048

Feasibility of training athletes for high-pressure situations using virtual reality.

PubMed

Stinson, Cheryl; Bowman, Doug A

2014-04-01

Virtual reality (VR) has been successfully applied to a broad range of training domains; however, to date there is little research investigating its benefits for sport psychology training. We hypothesized that using high-fidelity VR systems to display realistic 3D sport environments could trigger anxiety, allowing resilience-training systems to prepare athletes for real-world, highpressure situations. In this work we investigated the feasibility and usefulness of using VR for sport psychology training. We developed a virtual soccer goalkeeping application for the Virginia Tech Visionarium VisCube (a CAVE-like display system), in which users defend against simulated penalty kicks using their own bodies. Using the application, we ran a controlled, within-subjects experiment with three independent variables: known anxiety triggers, field of regard, and simulation fidelity. The results demonstrate that a VR sport-oriented system can induce increased anxiety (physiological and subjective measures) compared to a baseline condition. There were a number of main effects and interaction effects for all three independent variables in terms of the subjective measures of anxiety. Both known anxiety triggers and simulation fidelity had a direct relationship to anxiety, while field of regard had an inverse relationship. Overall, the results demonstrate great potential for VR sport psychology training systems; however, further research is needed to determine if training in a VR environment can lead to long-term reduction in sport-induced anxiety.

Trust in technology-mediated collaborative health encounters: constructing trust in passive user interactions with technologies.

PubMed

Montague, Enid; Asan, Onur

2012-01-01

The present study investigated factors that explain patient trust in health technology and the relationship between patient trust in technology and trust in their care provider. Sociotechnical systems theory states that changes in one part of the system are likely related to other parts of the system. Therefore, attitudes about technologies, like trust, are likely related to other aspects of the system. Contributing to appropriate trust at the technological, interpersonal, and system levels can potentially lead to positive health outcomes. The study described in this manuscript used data collected from 101 patients with a Trust in Medical Technology instrument. The instrument measured patients' trust in (1) their providers, (2) the technology, and (3) how their providers used the technology. Measure 3 was positively associated with measures 1 and 2, while measures 1 and 2 were not positively or negatively associated with one another. These results may indicate that patient assessments of the trustworthiness of care providers and technologies are based on their observations of how providers use technologies. Though patients are not active users of technologies in health care, the results of this study show that their perceptions of how providers use technology are related to their trust in both technology and the care provider. Study findings have implications for how trust is conceptualised and measured in interpersonal relationships and in technologies.

Client-nurse relationships in home-based palliative care: a critical analysis of power relations.

PubMed

Oudshoorn, Abram; Ward-Griffin, Catherine; McWilliam, Carol

2007-08-01

To elicit an in-depth understanding of the sources of power and how power is exercised within client-nurse relationships in home-based palliative care. As in all social relations, power is present within client-nurse relationships. Although much research has focused on interpersonal relationships in nursing, the concept of power within the client-nurse relationship in palliative care settings has not been extensively investigated. Applying a critical lens, secondary qualitative data analysis was conducted. Seventeen nurse and 16 client transcripts from a primary study were selected for secondary data analysis. These 33 transcripts afforded theme saturation, which allowed for both commonalities and differences to be identified. Data analysis involved analytic coding. Study findings help make explicit the underlying power present in the context of home-based palliative care and how this power is used and potentially abused. In analysing the sources and exercise of power, the linkage between macro and micro levels of power is made explicit, as nurses functioned within a hierarchy of power. The findings suggest that educational/occupational status continues to be a source of power for nurses within the relationship. However, nurses also experience powerlessness within the home care context. For clients, being able to control one's own life is a source of power, but this power is over-shadowed by the powerlessness experienced in relationships with nurses. The exercise of power by clients and nurses creates experiences of both liberation and domination. Nurses who are willing to reflect on and change those disempowering aspects of the client-nurse relationship, including a harmful hierarchy, will ultimately be successful in the health promotion of clients in home-based palliative care. Additionally, it should be recognized that nurses work within a specific health system context and, therefore, their practice is influenced by policies and funding models implemented at various levels of the health care system. The insights gained through this investigation may assist nurses and other health professionals in reflecting on and improving practices and policies within home-based palliative care and within home care in general.

Interpersonal mechanisms linking close relationships to health.

PubMed

Pietromonaco, Paula R; Collins, Nancy L

2017-09-01

Close relationships play a vital role in human health, but much remains to be learned about specific mechanisms of action and potential avenues for intervention. This article provides an evaluation of research on close relationships processes relevant to health, drawing on themes from major relationship science theories to present a broad conceptual framework for understanding the interpersonal processes and intrapersonal pathways linking relationships to health and disease outcomes. The analysis reveals that both social connection and social disconnection broadly shape biological responses and behaviors that are consequential for health. Furthermore, emerging work offers insights into the types of social dynamics that are most consequential for health, and the potential pathways through which they operate. Following from this analysis, the authors suggest several research priorities to facilitate the translation of discoveries from relationship science into relationship-based interventions and public health initiatives. These priorities include developing finer grained theoretical models to guide research, the systematic investigation of potential mediating pathways such as dyadic influences on health behavior and physiological coregulation, and taking into account individual differences and contextual factors such as attachment style, gender, socioeconomic status, and culture. In addition, a pressing need exists for laboratory and field research to determine which types of interventions are both practical and effective. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Use of fluorescence spectroscopy to control ozone dosage in recirculating aquaculture systems.

PubMed

Spiliotopoulou, Aikaterini; Martin, Richard; Pedersen, Lars-Flemming; Andersen, Henrik R

2017-03-15

The aim of this study was to investigate the potential of fluorescence spectroscopy to be used as an ozone dosage determination tool in recirculating aquaculture systems (RASs), by studying the relationship between fluorescence intensities and dissolved organic matter (DOM) degradation by ozone, in order to optimise ozonation treatment. Water samples from six different Danish facilities (two rearing units from a commercial trout RAS, a commercial eel RAS, a pilot RAS and two marine water aquariums) were treated with different O 3 dosages (1.0-20.0 mg/L ozone) in bench-scale experiments, following which fluorescence intensity degradation was eventually determined. Ozonation kinetic experiments showed that RAS water contains fluorescent organic matter, which is easily oxidised upon ozonation in relatively low concentrations (0-5 mg O 3 /L). Fluorescence spectroscopy has a high level of sensitivity and selectivity in relation to associated fluorophores, and it is able to determine accurately the ozone demand of each system. The findings can potentially be used to design offline or online sensors based on the reduction by ozone of natural fluorescent-dissolved organic matter in RAS. The suggested indirect determination of ozone delivered into water can potentially contribute to a safer and more adequate ozone-based treatment to improve water quality. Copyright © 2016 Elsevier Ltd. All rights reserved.

Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis

PubMed Central

Sharma, Nripen S.; Jindal, Rohit; Mitra, Bhaskar; Lee, Serom; Li, Lulu; Maguire, Tim J.; Schloss, Rene; Yarmush, Martin L.

2014-01-01

Skin sensitization remains a major environmental and occupational health hazard. Animal models have been used as the gold standard method of choice for estimating chemical sensitization potential. However, a growing international drive and consensus for minimizing animal usage have prompted the development of in vitro methods to assess chemical sensitivity. In this paper, we examine existing approaches including in silico models, cell and tissue based assays for distinguishing between sensitizers and irritants. The in silico approaches that have been discussed include Quantitative Structure Activity Relationships (QSAR) and QSAR based expert models that correlate chemical molecular structure with biological activity and mechanism based read-across models that incorporate compound electrophilicity. The cell and tissue based assays rely on an assortment of mono and co-culture cell systems in conjunction with 3D skin models. Given the complexity of allergen induced immune responses, and the limited ability of existing systems to capture the entire gamut of cellular and molecular events associated with these responses, we also introduce a microfabricated platform that can capture all the key steps involved in allergic contact sensitivity. Finally, we describe the development of an integrated testing strategy comprised of two or three tier systems for evaluating sensitization potential of chemicals. PMID:24741377

Pathways to low-cost electrochemical energy storage: a comparison of aqueous and nonaqueous flow batteries

DOE PAGES

Darling, Robert M.; Gallagher, Kevin G.; Kowalski, Jeffrey A.; ...

2014-11-01

Energy storage is increasingly seen as a valuable asset for electricity grids composed of high fractions of intermittent sources, such as wind power or, in developing economies, unreliable generation and transmission services. However, the potential of batteries to meet the stringent cost and durability requirements for grid applications is largely unquantified. We investigate electrochemical systems capable of economically storing energy for hours and present an analysis of the relationships among technological performance characteristics, component cost factors, and system price for established and conceptual aqueous and nonaqueous batteries. We identified potential advantages of nonaqueous flow batteries over those based on aqueousmore » electrolytes; however, new challenging constraints burden the nonaqueous approach, including the solubility of the active material in the electrolyte. Requirements in harmony with economically effective energy storage are derived for aqueous and nonaqueous systems. The attributes of flow batteries are compared to those of aqueous and nonaqueous enclosed and hybrid (semi-flow) batteries. Flow batteries are a promising technology for reaching these challenging energy storage targets owing to their independent power and energy scaling, reliance on facile and reversible reactants, and potentially simpler manufacture as compared to established enclosed batteries such as lead–acid or lithium-ion.« less

Cannabinoids and Schizophrenia: Risks and Therapeutic Potential.

PubMed

Manseau, Marc W; Goff, Donald C

2015-10-01

A convergence of evidence shows that use of Cannabis sativa is associated with increased risk of developing psychotic disorders, including schizophrenia, and earlier age at which psychotic symptoms first manifest. Cannabis exposure during adolescence is most strongly associated with the onset of psychosis amongst those who are particularly vulnerable, such as those who have been exposed to child abuse and those with family histories of schizophrenia. Schizophrenia that develops after cannabis use may have a unique clinical phenotype, and several genetic polymorphisms may modulate the relationship between cannabis use and psychosis. The endocannabinoid system has been implicated in psychosis both related and unrelated to cannabis exposure, and studying this system holds potential to increase understanding of the pathophysiology of schizophrenia. Anandamide signaling in the central nervous system may be particularly important. Δ(9)-Tetrahydrocannabinol in cannabis can cause symptoms of schizophrenia when acutely administered, and cannabidiol (CBD), another compound in cannabis, can counter many of these effects. CBD may have therapeutic potential for the treatment of psychosis following cannabis use, as well as schizophrenia, possibly with better tolerability than current antipsychotic treatments. CBD may also have anti-inflammatory and neuroprotective properties. Establishing the role of CBD and other CBD-based compounds in treating psychotic disorders will require further human research.

Toward a Model-Based Approach to Flight System Fault Protection

NASA Technical Reports Server (NTRS)

Day, John; Murray, Alex; Meakin, Peter

2012-01-01

Fault Protection (FP) is a distinct and separate systems engineering sub-discipline that is concerned with the off-nominal behavior of a system. Flight system fault protection is an important part of the overall flight system systems engineering effort, with its own products and processes. As with other aspects of systems engineering, the FP domain is highly amenable to expression and management in models. However, while there are standards and guidelines for performing FP related analyses, there are not standards or guidelines for formally relating the FP analyses to each other or to the system hardware and software design. As a result, the material generated for these analyses are effectively creating separate models that are only loosely-related to the system being designed. Development of approaches that enable modeling of FP concerns in the same model as the system hardware and software design enables establishment of formal relationships that has great potential for improving the efficiency, correctness, and verification of the implementation of flight system FP. This paper begins with an overview of the FP domain, and then continues with a presentation of a SysML/UML model of the FP domain and the particular analyses that it contains, by way of showing a potential model-based approach to flight system fault protection, and an exposition of the use of the FP models in FSW engineering. The analyses are small examples, inspired by current real-project examples of FP analyses.

Herbicides and nitrates in groundwater of Maryland and childhood cancers: a geographic information systems approach.

PubMed

Thorpe, Nancy; Shirmohammadi, Adel

2005-01-01

This hypothesis-generating study explores spatial patterns of childhood cancers in Maryland and investigates their potential associations with herbicides and nitrates in groundwater. The Maryland Cancer Registry (MCR) provided data for bone and brain cancers, leukemia, and lymphoma, for ages 0-17, during the years 1992-1998. Cancer clusters and relative risks generated in the study indicate higher relative risk areas and potential clusters in several counties. Contingency table analysis indicates a potential association with several herbicides and nitrates. Cancer rates for the four types have a crude odds ratio (OR) = 1.10 (0.78-1.56) in relationship to atrazine, and an OR = 1.54 (1.14-2.07) for metolachlor. Potential association to mixtures of three compounds give an OR = 7.56 (4.16-13.73). A potential association is indicated between leukemia and nitrates, OR = 1.81 (1.35-2.42), and bone cancer with metolachlor, OR = 2.26 (0.97-5.24). These results give insight to generate a hypothesis of the potential association between exposure to these herbicides and nitrates and specific types of childhood cancer.

Sequence-Dependent Structure/Function Relationships of Catalytic Peptide-Enabled Gold Nanoparticles Generated under Ambient Synthetic Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bedford, Nicholas M.; Hughes, Zak E.; Tang, Zhenghua

Peptide-enabled nanoparticle (NP) synthesis routes can create and/or assemble functional nanomaterials under environmentally friendly conditions, with properties dictated by complex interactions at the biotic/abiotic interface. Manipulation of this interface through sequence modification can provide the capability for material properties to be tailored to create enhanced materials for energy, catalysis, and sensing applications. Fully realizing the potential of these materials requires a comprehensive understanding of sequence-dependent structure/function relationships that is presently lacking. In this work, the atomic-scale structures of a series of peptide-capped Au NPs are determined using a combination of atomic pair distribution function analysis of high-energy X-ray diffraction datamore » and advanced molecular dynamics (MD) simulations. The Au NPs produced with different peptide sequences exhibit varying degrees of catalytic activity for the exemplar reaction 4-nitrophenol reduction. The experimentally derived atomic-scale NP configurations reveal sequence-dependent differences in structural order at the NP surface. Replica exchange with solute-tempering MD simulations are then used to predict the morphology of the peptide overlayer on these Au NPs and identify factors determining the structure/catalytic properties relationship. We show that the amount of exposed Au surface, the underlying surface structural disorder, and the interaction strength of the peptide with the Au surface all influence catalytic performance. A simplified computational prediction of catalytic performance is developed that can potentially serve as a screening tool for future studies. Our approach provides a platform for broadening the analysis of catalytic peptide-enabled metallic NP systems, potentially allowing for the development of rational design rules for property enhancement.« less

Density is not Destiny: Characterizing Terrestrial Exoplanet Geology from Stellar Compositional Abundances

NASA Astrophysics Data System (ADS)

Unterborn, Cayman T.

2018-01-01

A planet’s mass-radius relationship alone is not a good indicator for its potential to be "Earth-like." While useful in coarse characterizations for distinguishing whether an exoplanet is water/atmosphere- or rock/iron-dominated, there is considerable degeneracy in using the mass-radius relation to determine the mineralogy and structure of a purely terrestrial planet like the Earth. The chemical link between host-stars and rocky planets and the utility of this connection in breaking the degeneracy in the mass-radius relationship is well documented. Given the breadth of observed stellar compositions, modeling the complex effects of these compositional variations on a terrestrial planet’s mineralogy, structure and temperature profile, and the potential pitfalls therein, falls within the purview of the geosciences.I will demonstrate here, the utility in adopting the composition of a terrestrial planet’s host star for contextualizing individual systems (e.g. TRAPPIST-1), as well as for the more general case of quantifying the geophysical consequences of stellar compositional diversity. This includes the potential for a host-star to produce planets able to undergo mantle convection, surface-to-interior degassing and long-term plate tectonics. As we search for truly “Earth-like” planets, we must move away from the simple density-driven definition of “Earth-like” and towards a more holistic view that includes both geochemistry and geophysics. Combining geophysical models and those of planetary formation with host-star abundance data, then, is of paramount importance. This will aid not only in our understanding of the mass-radius relationship but also provide foundational results necessary interpreting future atmospheric observations through the lens of surface-interior interactions (e.g. volcanism) and planetary evolution as a whole.

Measurement of health system performance at district level: A study protocol

PubMed Central

Sharma, Atul; Prinja, Shankar; Aggarwal, Arun Kumar

2018-01-01

Background Limited efforts have been observed in low and middle income countries to undertake health system performance assessment at district level. Absence of a comprehensive data collection tool and lack of a standardised single summary measure defining overall performance are some of the main problems. Present study has been undertaken to develop a summary composite health system performance index at district level. Methods A broad range of indicators covering all six domains as per building block framework were finalized by an expert panel. The domains were classified into twenty sub-domains, with 70 input and process indicators to measure performance. Seven sub-domains for assessing health system outputs and outcomes were identified, with a total of 28 indicators. Districts in Haryana state from north India were selected for the study. Primary and secondary data will be collected from 378 health facilities, district and state health directorate headquarters. Indicators will be normalized, aggregated to generate composite performance index at district level. Domain specific scores will present the quality of individual building block domains in the public health system. Robustness of the results will be checked using sensitivity analysis. Expected impact for public health: The study presents a methodology for comprehensive assessment of all health system domains on basis of input, process, output and outcome indicators which has never been reported from India. Generation of this index will help identify policy and implementation areas of concern and point towards potential solutions. Results may also help understand relationships between individual building blocks and their sub-components. Significance for public health Measuring performance of health system is important to understand progress and challenges, and create systems that are efficient, equitable and patient-focused. However, very few assessments of such nature have been observed in low and middle income countries, especially at district level, mainly because of methodological challenges. This study presents a methodology for comprehensive assessment of all domains of health system and generation of a composite Health System Performance Index on the basis of input, process, output and outcome indicators. It will help identify policy and implementation problems worthy of attention and point towards potential solutions to health system bottlenecks resulting in poor performance. The results may also help better understand the relationships between individual building blocks and their sub-components and the overall performance of the health system. PMID:29441330

Respiratory infections and acute lung injury in systemic illness.

PubMed

Skerrett, S J; Niederman, M S; Fein, A M

1989-12-01

We have discussed the relationship between systemic illness, infection, and lung disease. As we have seen, patients with a wide variety of disease states, including advanced age, diabetes mellitus, alcoholism, collagen vascular disease, cancer, heart failure, and organ transplantation are potentially at increased risk for pneumonia because of disease-related impairments in host defenses. In addition, two virtually ubiquitous conditions in hospitalized patients, malnutrition and therapeutic interventions (especially with common medications), frequently add to the risk of airway invasion by bacterial pathogens. Systemic illness not only makes lung infection more common, but may adversely affect outcome and resolution, as well as determine the clinical presentation of pneumonia. In one particular population, the intubated and mechanically ventilated patient, the risk of infection is particularly high, and nosocomial pneumonia is a major cause of mortality. To the extent that the host response itself leads to the symptoms and signs of infection, systemically ill individuals may have subtle clinical features when serious bacterial invasion is present. Many components of the host defense system can become abnormal with serious illness, but a common mechanism that ties many systemic diseases to pneumonia is an alteration in airway epithelial cell receptivity for bacteria, namely, bacterial adherence, a process that mediates airway colonization, the first pathogenetic step on the road to pneumonia. The impetus for understanding how serious illness promotes lung infection is that once these mechanisms are identified, potential preventative strategies to minimize infection risk in the individual with systemic disease may be developed. The relationship among systemic illness, the lung, and infection also exists in a different direction: infection of a systemic nature (the septic syndrome) can lead to disease in the lung (ARDS). We have described the features of the septic syndrome and identified how it may lead to lung injury, usually by indirect means, through activation of inflammatory mediators that are carried to the lung via the vasculature. Although it is frequently impossible to predict which specific patient with systemic sepsis will develop acute lung injury, the current state of knowledge does permit us to identify high-risk individuals. Surprisingly, clinical assessment rather than biochemical testing is the best predictor of the development of acute lung injury. Patients with severe injury, profound shock and multiple systemic insults are most prone to acute lung injury in the presence of systemic sepsis.(ABSTRACT TRUNCATED AT 400 WORDS)

Management system, organizational climate and performance relationships

NASA Technical Reports Server (NTRS)

Davis, B. D.

1979-01-01

Seven aerospace firms were investigated to determine if a relationship existed among management systems, organizational climate, and organization performance. Positive relationships were found between each of these variables, but a statistically significant relationship existed only between the management system and organizational climate. The direction and amount of communication and the degree of decentralized decision-making, elements of the management system, also had a statistically significant realtionship with organization performance.

Full Two-Body Problem Mass Parameter Observability Explored Through Doubly Synchronous Systems

NASA Astrophysics Data System (ADS)

Davis, Alex Benjamin; Scheeres, Daniel

2018-04-01

The full two-body problem (F2BP) is often used to model binary asteroid systems, representing the bodies as two finite mass distributions whose dynamics are influenced by their mutual gravity potential. The emergent behavior of the F2BP is highly coupled translational and rotational mutual motion of the mass distributions. For these systems the doubly synchronous equilibrium occurs when both bodies are tidally-locked and in a circular co-orbit. Stable oscillations about this equilibrium can be shown, for the nonplanar system, to be combinations of seven fundamental frequencies of the system and the mutual orbit rate. The fundamental frequencies arise as the linear periods of center manifolds identified about the equilibrium which are heavily influenced by each body’s mass parameters. We leverage these eight dynamical constraints to investigate the observability of binary asteroid mass parameters via dynamical observations. This is accomplished by proving the nonsingularity of the relationship between the frequencies and mass parameters for doubly synchronous systems. Thus we can invert the relationship to show that given observations of the frequencies, we can solve for the mass parameters of a target system. In so doing we are able to predict the estimation covariance of the mass parameters based on observation quality and define necessary observation accuracies for desired mass parameter certainties. We apply these tools to 617 Patroclus, a doubly synchronous Trojan binary and flyby target of the LUCY mission, as well as the Pluto and Charon system in order to predict mutual behaviors of these doubly synchronous systems and to provide observational requirements for these systems’ mass parameters

The x-ray light valve: a potentially low-cost, digital radiographic imaging system--a liquid crystal cell design for chest radiography.

PubMed

Szeto, Timothy C; Webster, Christie Ann; Koprinarov, Ivaylo; Rowlands, J A

2008-03-01

Digital x-ray radiographic systems are desirable as they offer high quality images which can be processed, transferred, and stored without secondary steps. However, current clinical systems are extraordinarily expensive in comparison to film-based systems. Thus, there is a need for an economical digital imaging system for general radiology. The x-ray light valve (XLV) is a novel digital x-ray detector concept with the potential for high image quality and low cost. The XLV is comprised of a photoconductive detector layer and liquid crystal (LC) cell physically coupled in a sandwich structure. Upon exposure to x rays, charge is collected at the surface of the photoconductor, causing a change in the reflective properties of the LC cell. The visible image so formed can subsequently be digitized with an optical scanner. By choosing the properties of the LC cell in combination with the appropriate photoconductor thickness and bias potentials, the XLV can be optimized for various diagnostic imaging tasks. Specifically for chest radiography, we identified three potentially practical reflective cell designs by selecting from those commonly used in LC display technology. The relationship between reflectance and x-ray exposure (i.e., the characteristic curve) was determined for all three cells using a theoretical model. The results indicate that the reflective electrically controlled birefringence (r-ECB) cell is the preferred choice for chest radiography, provided that the characteristic curve can be shifted towards lower exposures. The feasibility of the shift of the characteristic curve is shown experimentally. The experimental results thus demonstrate that an XLV based on the r-ECB cell design exhibits a characteristic curve suitable for chest radiography.

Potentially traumatic events, personality, and risky sexual behavior in undergraduate college students.

PubMed

Moore, Ashlee A; Overstreet, Cassie; Kendler, Kenneth S; Dick, Danielle M; Adkins, Amy; Amstadter, Ananda B

2017-01-01

Impulsivity and extraversion have demonstrated associations with risky sexual behavior (RSB) and potentially traumatic events (PTEs). In addition, interpersonal trauma appears to be associated with RSB, but research on the relationship between RSB and noninterpersonal PTEs (e.g., accidental) is lacking. The current study aims to investigate the relationships between personality (i.e., impulsivity, extraversion), RSB and multiple types of PTEs (i.e., accidental, physical, or sexual). Personality and demographic characteristics were assessed during participants' (N = 970) first semester of college, past-12 month PTEs and RSB were assessed during the second semester of participants' junior year. Multiple linear regression was used to examine the relationship between PTEs, personality factors, and RSB. Analyses were also conducted to examine the potential mediating effect of interpersonal PTEs on the relationship between personality and RSB. Impulsivity and extraversion were significantly positively associated with RSB. Both physical and sexual PTEs, but not accidental PTEs, were also significantly positively associated with RSB. Sexual PTEs significantly mediated the relationship between impulsivity and RSB. This is the first study to date to simultaneously examine the relationship between personality, RSB, and types of PTEs in a large sample of young adults. Exposure to interpersonal trauma appears to be a salient factor in the relationship between personality, specifically impulsivity, and RSB. These results indicate that college students may benefit from education regarding the potential negative outcomes of RSB, and that individuals with a history of interpersonal PTEs may be at increased risk for sexual risk taking. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Potentially traumatic events, personality and risky sexual behavior in undergraduate college students

PubMed Central

Moore, Ashlee A.; Overstreet, Cassie; Kendler, Kenneth S.; Dick, Danielle M.; Adkins, Amy; Amstadter, Ananda B.

2016-01-01

Objective Impulsivity and extraversion have demonstrated associations with risky sexual behavior (RSB) and potentially traumatic events (PTEs). In addition, interpersonal trauma appears to be associated with RSB, but research on the relationship between RSB and non-interpersonal PTEs (e.g., accidental) is lacking. The current study aims to investigate the relationships between personality (i.e., impulsivity, extraversion), RSB and multiple types of PTEs (i.e., accidental, physical, sexual). Methods Personality and demographic characteristics were assessed during participants’ (N = 970) first semester of college, past-12 month PTEs and RSB were assessed during the second semester of participants’ junior year. Multiple linear regression was used to examine the relationship between PTEs, personality factors, and RSB. Analyses were also conducted to examine the potential mediating effect of interpersonal PTEs on the relationship between personality and RSB. Results Impulsivity and extraversion were significantly positively associated with RSB. Both physical and sexual PTEs, but not accidental PTEs, were also significantly positively associated with RSB. Sexual PTEs significantly mediated the relationship between impulsivity and RSB. Conclusions This is the first study to date to simultaneously examine the relationship between personality, RSB, and types of PTEs in a large sample of young adults. Exposure to interpersonal trauma appears to be a salient factor in the relationship between personality, specifically impulsivity, and RSB. These results indicate that college students may benefit from education regarding the potential negative outcomes of RSB, and that individuals with a history of interpersonal PTEs may be at increased risk for sexual risk taking. PMID:27348066

Faculty-Student Dual Relationships: Implications for Counselor Educators

ERIC Educational Resources Information Center

Jackson, James L.

2007-01-01

This article considers dual relationships between faculty and students from an ethical perspective. A review of the literature focuses on the potential impact of dual relationships on students, faculty, academic institutions, and the consumers students will ultimately serve. Models promoting ethical dual relationships are identified and strategies…

Spring-Blade Impact Tester

NASA Technical Reports Server (NTRS)

Holmes, Alan M.; Champagne, James W.

1989-01-01

Record of energy relationships retrieved from compact, portable tester. Spring-blade impact tester developed to support evaluation of tolerance to damage of struts under consideration for use in Space Station. Approach offers potential for determining damage as function of change in relationship between applied and absorbed energies as applied energy successively increased with each impact. Impactor strikes specimen at moment of maximum kinetic energy after spring blades released from cocked position. Concept also provides potential for measuring behavior during impact, and energy relationships retrievable from oscilloscope traces of impact.

Building Local Infrastructure for Community Adoption of Science-Based Prevention: The Role of Coalition Functioning.

PubMed

Shapiro, Valerie B; Hawkins, J David; Oesterle, Sabrina

2015-11-01

The widespread adoption of science-based prevention requires local infrastructures for prevention service delivery. Communities That Care (CTC) is a tested prevention service delivery system that enables a local coalition of community stakeholders to use a science-based approach to prevention and improve the behavioral health of young people. This paper uses data from the Community Youth Development Study (CYDS), a community-randomized trial of CTC, to examine the extent to which better internal team functioning of CTC coalitions increases the community-wide adoption of science-based prevention within 12 communities, relative to 12 matched comparison communities. Specifically, this paper examines the potential of both a direct relationship between coalition functioning and the community-wide adoption of science-based prevention and a direct relationship between functioning and the coalition capacities that ultimately enable the adoption of science-based prevention. Findings indicate no evidence of a direct relationship between four dimensions of coalition functioning and the community-wide adoption of a science-based approach to prevention, but suggest a relationship between coalition functioning and coalition capacities (building new member skills and establishing external linkages with existing community organizations) that enable science-based prevention.

Associations Between Socioeconomic Status and Allostatic Load: Effects of Neighborhood Poverty and Tests of Mediating Pathways

PubMed Central

Mentz, Graciela; Lachance, Laurie; Johnson, Jonetta; Gaines, Causandra; Israel, Barbara A.

2012-01-01

Objectives. We examined relationships between neighborhood poverty and allostatic load in a low- to moderate-income multiracial urban community. We tested the hypothesis that neighborhood poverty is associated with allostatic load, controlling for household poverty. We also examined the hypotheses that this association was mediated by psychosocial stress and health-related behaviors. Methods. We conducted multilevel analyses using cross-sectional data from a probability sample survey in Detroit, Michigan (n = 919) and the 2000 US Census. The outcome measure was allostatic load. Independent variables included neighborhood and household poverty, psychosocial stress, and health-related behaviors. Covariates included neighborhood and individual demographic characteristics. Results. Neighborhood poverty was positively associated with allostatic load (P < .05), independent of household poverty and controlling for potential confounders. Relationships between neighborhood poverty were mediated by self-reported neighborhood environment stress but not by health-related behaviors. Conclusions. Neighborhood poverty is associated with wear and tear on physiological systems, and this relationship is mediated through psychosocial stress. These relationships are evident after accounting for household poverty levels. Efforts to promote health equity should focus on neighborhood poverty, associated stressful environmental conditions, and household poverty. PMID:22873478

Associations between socioeconomic status and allostatic load: effects of neighborhood poverty and tests of mediating pathways.

PubMed

Schulz, Amy J; Mentz, Graciela; Lachance, Laurie; Johnson, Jonetta; Gaines, Causandra; Israel, Barbara A

2012-09-01

We examined relationships between neighborhood poverty and allostatic load in a low- to moderate-income multiracial urban community. We tested the hypothesis that neighborhood poverty is associated with allostatic load, controlling for household poverty. We also examined the hypotheses that this association was mediated by psychosocial stress and health-related behaviors. We conducted multilevel analyses using cross-sectional data from a probability sample survey in Detroit, Michigan (n = 919) and the 2000 US Census. The outcome measure was allostatic load. Independent variables included neighborhood and household poverty, psychosocial stress, and health-related behaviors. Covariates included neighborhood and individual demographic characteristics. Neighborhood poverty was positively associated with allostatic load (P < .05), independent of household poverty and controlling for potential confounders. Relationships between neighborhood poverty were mediated by self-reported neighborhood environment stress but not by health-related behaviors. Neighborhood poverty is associated with wear and tear on physiological systems, and this relationship is mediated through psychosocial stress. These relationships are evident after accounting for household poverty levels. Efforts to promote health equity should focus on neighborhood poverty, associated stressful environmental conditions, and household poverty.

A new "twist" on right heart failure with left ventricular assist systems.

PubMed

Houston, Brian A; Shah, Keyur B; Mehra, Mandeep R; Tedford, Ryan J

2017-07-01

Despite significant efforts to predict and prevent right heart failure, it remains a leading cause of morbidity and mortality after implantation of left ventricular assist systems (LVAS). In this Perspective, we review the underappreciated anatomic and physiologic principles that govern the relationship between left and right heart function and contribute to this phenomenon. This includes the importance of considering the right ventricle (RV) and pulmonary arterial circuit as a coupled system; the contribution of the left ventricle (LV) to RV contractile function and the potential negative impact of acutely unloading the LV; the influence of the pericardium and ventricular twist on septal function; the role of RV deformation in reduced mechanical efficiency after device placement; and the potential of ongoing stressors of an elevated right-sided preload. We believe an appreciation of these complex issues is required to fully understand the expression of the unique phenotypes of right heart failure after LVAS implantation and for developing better prognostic and therapeutic strategies. Copyright © 2017 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

Bioenergy Development Policy and Practice Must Recognize Potential Hydrologic Impacts: Lessons from the Americas.

PubMed

Watkins, David W; de Moraes, Márcia M G Alcoforado; Asbjornsen, Heidi; Mayer, Alex S; Licata, Julian; Lopez, Jose Gutierrez; Pypker, Thomas G; Molina, Vivianna Gamez; Marques, Guilherme Fernandes; Carneiro, Ana Cristina Guimaraes; Nuñez, Hector M; Önal, Hayri; da Nobrega Germano, Bruna

2015-12-01

Large-scale bioenergy production will affect the hydrologic cycle in multiple ways, including changes in canopy interception, evapotranspiration, infiltration, and the quantity and quality of surface runoff and groundwater recharge. As such, the water footprints of bioenergy sources vary significantly by type of feedstock, soil characteristics, cultivation practices, and hydro-climatic regime. Furthermore, water management implications of bioenergy production depend on existing land use, relative water availability, and competing water uses at a watershed scale. This paper reviews previous research on the water resource impacts of bioenergy production-from plot-scale hydrologic and nutrient cycling impacts to watershed and regional scale hydro-economic systems relationships. Primary gaps in knowledge that hinder policy development for integrated management of water-bioenergy systems are highlighted. Four case studies in the Americas are analyzed to illustrate relevant spatial and temporal scales for impact assessment, along with unique aspects of biofuel production compared to other agroforestry systems, such as energy-related conflicts and tradeoffs. Based on the case studies, the potential benefits of integrated resource management are assessed, as is the need for further case-specific research.

Electromechanical impedance-based health diagnosis for tendon and anchorage zone in a nuclear containment structure

NASA Astrophysics Data System (ADS)

Min, Jiyoung; Shim, Hyojin; Yun, Chung-Bang

2012-04-01

For a nuclear containment structure, the structural health monitoring is essential because of its high potential risk and grave social impact. In particular, the tendon and anchorage zone are to be monitored because they are under high tensile or compressive stress. In this paper, a method to monitor the tendon force and the condition of the anchorage zone is presented by using the impedance-based health diagnosis system. First, numerical simulations were conducted for cases with various loose tensile forces on the tendon as well as damages on the bearing plate and concrete structure. Then, experimental studies were carried out on a scaled model of the anchorage system. The relationship between the loose tensile force and the impedance-based damage index was analyzed by a regression analysis. When a structure gets damaged, the damage index increases so that the status of damage can be identified. The results of the numerical and experimental studies indicate a big potential of the proposed impedance-based method for monitoring the tendon and anchorage system.

Opioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance.

PubMed

Mercer, Susan L; Coop, Andrew

2011-01-01

Chronic clinical pain remains poorly treated. Despite attempts to develop novel analgesic agents, opioids remain the standard analgesics of choice in the clinical management of chronic and severe pain. However, mu opioid analgesics have undesired side effects including, but not limited to, respiratory depression, physical dependence and tolerance. A growing body of evidence suggests that P-glycoprotein (P-gp), an efflux transporter, may contribute a systems-level approach to the development of opioid tolerance. Herein, we describe current in vitro and in vivo methodology available to analyze interactions between opioids and P-gp and critically analyze P-gp data associated with six commonly used mu opioids to include morphine, methadone, loperamide, meperidine, oxycodone, and fentanyl. Recent studies focused on the development of opioids lacking P-gp substrate activity are explored, concentrating on structure-activity relationships to develop an optimal opioid analgesic lacking this systems-level contribution to tolerance development. Continued work in this area will potentially allow for delineation of the mechanism responsible for opioid-related P-gp up-regulation and provide further support for evidence based medicine supporting clinical opioid rotation.

Bioenergy Development Policy and Practice Must Recognize Potential Hydrologic Impacts: Lessons from the Americas

NASA Astrophysics Data System (ADS)

Watkins, David W.; de Moraes, Márcia M. G. Alcoforado; Asbjornsen, Heidi; Mayer, Alex S.; Licata, Julian; Lopez, Jose Gutierrez; Pypker, Thomas G.; Molina, Vivianna Gamez; Marques, Guilherme Fernandes; Carneiro, Ana Cristina Guimaraes; Nuñez, Hector M.; Önal, Hayri; da Nobrega Germano, Bruna

2015-12-01

Large-scale bioenergy production will affect the hydrologic cycle in multiple ways, including changes in canopy interception, evapotranspiration, infiltration, and the quantity and quality of surface runoff and groundwater recharge. As such, the water footprints of bioenergy sources vary significantly by type of feedstock, soil characteristics, cultivation practices, and hydro-climatic regime. Furthermore, water management implications of bioenergy production depend on existing land use, relative water availability, and competing water uses at a watershed scale. This paper reviews previous research on the water resource impacts of bioenergy production—from plot-scale hydrologic and nutrient cycling impacts to watershed and regional scale hydro-economic systems relationships. Primary gaps in knowledge that hinder policy development for integrated management of water-bioenergy systems are highlighted. Four case studies in the Americas are analyzed to illustrate relevant spatial and temporal scales for impact assessment, along with unique aspects of biofuel production compared to other agroforestry systems, such as energy-related conflicts and tradeoffs. Based on the case studies, the potential benefits of integrated resource management are assessed, as is the need for further case-specific research.

New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: spectroscopic, electrochemistry, and cellular studies.

PubMed

Mura, F; Silva, T; Castro, C; Borges, F; Zuñiga, M C; Morales, J; Olea-Azar, C

2014-12-01

A series hydroxycinnamic and gallic acids and their derivatives were studied with the aim of evaluating their in vitro antioxidant properties both in homogeneous and in cellular systems. It was concluded from the oxygen radical absorbance capacity-fluorescein (ORAC-FL), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and cyclic voltammetry data that some compounds exhibit remarkable antioxidant properties. In general, in homogeneous media (DPPH assay), galloyl-based cinnamic and benzoic systems (compounds 7-11) were the most active, exhibiting the lowest oxidation potentials in both dimethyl sulfoxide (DMSO) and phosphate buffer. Yet, p-coumaric acid and its derivatives (compounds 1-3) disclosed the highest scavenging activity toward peroxyl radicals (ORAC-FL assay). Interesting structure-property- activity relationships between ORAC-FL, or DPPH radical, and redox potentials have been attained, showing that the latter parameter can be a valuable antioxidant measure. It was evidenced that redox potentials are related to the structural features of cinnamic and benzoic systems and that their activities are also dependent on the radical generated in the assay. Electron spin resonance data of the phenoxyl radicals generated both in DMSO and phosphate buffer support the assumption that radical stability is related to the type of phenolic system. Galloyl-based cinnamic and benzoic ester-type systems (compounds 9 and 11) were the most active and effective compounds in cell-based assays (51.13 ± 1.27% and 54.90 ± 3.65%, respectively). In cellular systems, hydroxycinnamic and hydroxybenzoic systems operate based on their intrinsic antioxidant outline and lipophilic properties, so the balance between these two properties is considered of the utmost importance to ensure their performance in the prevention or minimization of the effects due to free radical overproduction.

A Meta-Analysis of Multiple Matched Copy Number and Transcriptomics Data Sets for Inferring Gene Regulatory Relationships

PubMed Central

Newton, Richard; Wernisch, Lorenz

2014-01-01

Inferring gene regulatory relationships from observational data is challenging. Manipulation and intervention is often required to unravel causal relationships unambiguously. However, gene copy number changes, as they frequently occur in cancer cells, might be considered natural manipulation experiments on gene expression. An increasing number of data sets on matched array comparative genomic hybridisation and transcriptomics experiments from a variety of cancer pathologies are becoming publicly available. Here we explore the potential of a meta-analysis of thirty such data sets. The aim of our analysis was to assess the potential of in silico inference of trans-acting gene regulatory relationships from this type of data. We found sufficient correlation signal in the data to infer gene regulatory relationships, with interesting similarities between data sets. A number of genes had highly correlated copy number and expression changes in many of the data sets and we present predicted potential trans-acted regulatory relationships for each of these genes. The study also investigates to what extent heterogeneity between cell types and between pathologies determines the number of statistically significant predictions available from a meta-analysis of experiments. PMID:25148247

Radiofrequency ablation: importance of background tissue electrical conductivity--an agar phantom and computer modeling study.

PubMed

Solazzo, Stephanie A; Liu, Zhengjun; Lobo, S Melvyn; Ahmed, Muneeb; Hines-Peralta, Andrew U; Lenkinski, Robert E; Goldberg, S Nahum

2005-08-01

To determine whether radiofrequency (RF)-induced heating can be correlated with background electrical conductivity in a controlled experimental phantom environment mimicking different background tissue electrical conductivities and to determine the potential electrical and physical basis for such a correlation by using computer modeling. The effect of background tissue electrical conductivity on RF-induced heating was studied in a controlled system of 80 two-compartment agar phantoms (with inner wells of 0.3%, 1.0%, or 36.0% NaCl) with background conductivity that varied from 0.6% to 5.0% NaCl. Mathematical modeling of the relationship between electrical conductivity and temperatures 2 cm from the electrode (T2cm) was performed. Next, computer simulation of RF heating by using two-dimensional finite-element analysis (ETherm) was performed with parameters selected to approximate the agar phantoms. Resultant heating, in terms of both the T2cm and the distance of defined thermal isotherms from the electrode surface, was calculated and compared with the phantom data. Additionally, electrical and thermal profiles were determined by using the computer modeling data and correlated by using linear regression analysis. For each inner compartment NaCl concentration, a negative exponential relationship was established between increased background NaCl concentration and the T2cm (R2= 0.64-0.78). Similar negative exponential relationships (r2 > 0.97%) were observed for the computer modeling. Correlation values (R2) between the computer and experimental data were 0.9, 0.9, and 0.55 for the 0.3%, 1.0%, and 36.0% inner NaCl concentrations, respectively. Plotting of the electrical field generated around the RF electrode identified the potential for a dramatic local change in electrical field distribution (ie, a second electrical peak ["E-peak"]) occurring at the interface between the two compartments of varied electrical background conductivity. Linear correlations between the E-peak and heating at T2cm (R2= 0.98-1.00) and the 50 degrees C isotherm (R2= 0.99-1.00) were established. These results demonstrate the strong relationship between background tissue conductivity and RF heating and further explain electrical phenomena that occur in a two-compartment system.

News media reporting on civil litigation and its influence on civil justice decision making.

PubMed

Robbennolt, Jennifer K; Studebaker, Christina A

2003-02-01

The news media have the potential to act as a powerful influence on the civil litigation system, influencing decision making in particular cases and on the system more generally as media reports influence the decision making of various participants in the system. This paper reviews the research that has examined the relationship between news media reporting and civil litigation and proposes a framework that integrates this work and provides guidance for future research efforts. Specifically, we discuss the nature of media reporting on civil litigation, perceptions of the civil litigation system held by the public and legal actors, and the potential influence of news reporting about civil litigation on the decision making of jurors, judges, civil litigants, and policymakers. Overall, the research suggests that news reporting of civil litigation presents a systematically distorted picture of civil litigation and that this reporting can influence perceptions and outcomes of civil litigation in various ways. However, there are many gaps in the existing research that need to be filled. The proposed organizational scheme helps to identify ways that future research can provide links between the findings of existing research and to identify ways in which this research can be extended to new areas.

Neuroendocrine host factors and inflammatory disease susceptibility.

PubMed Central

Ligier, S; Sternberg, E M

1999-01-01

The etiology of autoimmune diseases is multifactorial, resulting from a combination of genetically predetermined host characteristics and environmental exposures. As the term autoimmune implies, immune dysfunction and dysregulated self-tolerance are key elements in the pathophysiology of all these diseases. The neuroendocrine and sympathetic nervous systems are increasingly recognized as modulators of the immune response at the levels of both early inflammation and specific immunity. As such, alterations in their response represent a potential mechanism by which pathologic autoimmunity may develop. Animal models of autoimmune diseases show pre-existing changes in neuroendocrine responses to a variety of stimuli, and both animal and human studies have shown altered stress responses in the setting of active immune activation. The potential role of the neuroendocrine system in linking environmental exposures and autoimmune diseases is 2-fold. First, it may represent a direct target for toxic compounds. Second, its inadequate function may result in the inappropriate response of the immune system to an environmental agent with immunogenic properties. This article reviews the relationship between autoimmune diseases and the neuroendocrine system and discusses the difficulties and pitfalls of investigating a physiologic response that is sensitive to such a multiplicity of environmental exposures. PMID:10502534

Development of an ecotoxicity QSAR model for the KAshinhou Tool for Ecotoxicity (KATE) system, March 2009 version.

PubMed

Furuhama, A; Toida, T; Nishikawa, N; Aoki, Y; Yoshioka, Y; Shiraishi, H

2010-07-01

The KAshinhou Tool for Ecotoxicity (KATE) system, including ecotoxicity quantitative structure-activity relationship (QSAR) models, was developed by the Japanese National Institute for Environmental Studies (NIES) using the database of aquatic toxicity results gathered by the Japanese Ministry of the Environment and the US EPA fathead minnow database. In this system chemicals can be entered according to their one-dimensional structures and classified by substructure. The QSAR equations for predicting the toxicity of a chemical compound assume a linear correlation between its log P value and its aquatic toxicity. KATE uses a structural domain called C-judgement, defined by the substructures of specified functional groups in the QSAR models. Internal validation by the leave-one-out method confirms that the QSAR equations, with r(2 )> 0.7, RMSE 5, give acceptable q(2) values. Such external validation indicates that a group of chemicals with an in-domain of KATE C-judgements exhibits a lower root mean square error (RMSE). These findings demonstrate that the KATE system has the potential to enable chemicals to be categorised as potential hazards.

Recent developments in skin mimic systems to predict transdermal permeation.

PubMed

Waters, Laura J

2015-01-01

In recent years there has been a drive to create experimental techniques that can facilitate the accurate and precise prediction of transdermal permeation without the use of in vivo studies. This review considers why permeation data is essential, provides a brief summary as to how skin acts as a natural barrier to permeation and discusses why in vivo studies are undesirable. This is followed by an in-depth discussion on the extensive range of alternative methods that have been developed in recent years. All of the major 'skin mimic systems' are considered including: in vitro models using synthetic membranes, mathematical models including quantitative structure-permeability relationships (QSPRs), human skin equivalents and chromatographic based methods. All of these model based systems are ideally trying to achieve the same end-point, namely a reliable in vitro-in vivo correlation, i.e. matching non-in vivo obtained data with that from human clinical trials. It is only by achieving this aim, that any new method of obtaining permeation data can be acknowledged as a potential replacement for animal studies, for the determination of transdermal permeation. In this review, the relevance and potential applicability of the various models systems will also be discussed.

A novel in vitro whole plant system for analysis of polyphenolics and their antioxidant potential in cultivars of Ocimum basilicum.

PubMed

Srivastava, Shivani; Cahill, David M; Conlan, Xavier A; Adholeya, Alok

2014-10-15

Plants are an important source for medicinal compounds. Chemical screening and selection is critical for identification of compounds of interest. Ocimum basilicum (Basil) is a rich source of polyphenolics and exhibits high diversity, therefore bioprospecting of a suitable cultivar is a necessity. This study reports on the development of a true to type novel "in vitro system" and its comparison with a conventional system for screening and selection of cultivars for high total phenolics, individual polyphenolics, and antioxidant content. We have shown for the first time using online acidic potassium permanganate chemiluminescence that extracts from Ocimum basilicum showed antioxidant potential. The current study identified the cultivar specific composition of polyphenolics and their antioxidant properties. Further, a distinct relationship between plant morphotype and polyphenolic content was also found. Of the 15 cultivars examined, "Holy Green", "Red Rubin", and "Basil Genovese" were identified as high polyphenolic producing cultivars while "Subja" was determined to be a low producer. The "in vitro system" enabled differentiation of the cultivars in their morphology, polyphenolic content, and antioxidant activity and is a cheap and efficient method for bioprospecting studies.

Performance Estimation for Two-Dimensional Brownian Rotary Ratchet Systems

NASA Astrophysics Data System (ADS)

Tutu, Hiroki; Horita, Takehiko; Ouchi, Katsuya

2015-04-01

Within the context of the Brownian ratchet model, a molecular rotary system that can perform unidirectional rotations induced by linearly polarized ac fields and produce positive work under loads was studied. The model is based on the Langevin equation for a particle in a two-dimensional (2D) three-tooth ratchet potential of threefold symmetry. The performance of the system is characterized by the coercive torque, i.e., the strength of the load competing with the torque induced by the ac driving field, and the energy efficiency in force conversion from the driving field to the torque. We propose a master equation for coarse-grained states, which takes into account the boundary motion between states, and develop a kinetic description to estimate the mean angular momentum (MAM) and powers relevant to the energy balance equation. The framework of analysis incorporates several 2D characteristics and is applicable to a wide class of models of smooth 2D ratchet potential. We confirm that the obtained expressions for MAM, power, and efficiency of the model can enable us to predict qualitative behaviors. We also discuss the usefulness of the torque/power relationship for experimental analyses, and propose a characteristic for 2D ratchet systems.