Intestinal Malabsorption in Long-Term Survivors of Cervical Cancer Treated With Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vistad, Ingvild; Department of Gynecological Oncology, Norwegian Radium Hospital, Oslo; Kristensen, Gunnar B.

Purpose: The aim of this cross-sectional study is to investigate the associations between pelvic radiotherapy (RT) and markers of intestinal absorption in cervical cancer survivors (CCSs). We compared patient data with normative data from a reference population and explored the associations between cobalamin status and clinically significant diarrhea and depression. Methods and Materials: Fifty-five CCSs treated with RT in 1994-1999 were included in 2005 in a follow-up questionnaire study exploring physical and psychological symptoms. Blood tests, including serum (S)-vitamin B{sub 12,} S-methylmalonic acid, S-folate, erythrocyte-folate, and plasma homocysteine, were analyzed. Differences in median values between CCSs and reference populations weremore » evaluated by using Wilcoxon tests. Associations between variables were examined by means of multiple regression analyses. Results: Median S-vitamin B{sub 12} level was significantly lower and median S-methylmalonic acid level was significantly higher in CCSs compared with the reference population (p < 0.001). Correction for renal function verified a likely cobalamin deficiency in 20% of CCSs (11 of 55). Diarrhea or depression was not significantly related to any of the mentioned markers of cobalamin or folate status. Fifteen percent of CCSs (8 of 55) had subnormal S-calcium values. Conclusions: Significant cobalamin deficiency was observed in 11 (20%) and low calcium level was observed in 8 CCSs (15%) 6-12 years after pelvic RT. Neither diarrhea nor depression was associated with this deficiency. Routine monitoring of S-vitamin B{sub 12} level is recommended, and regular intake of cobalamin should be considered in CCSs treated with RT.« less

Looking for trouble: Adherence to late-effects surveillance among childhood cancer survivors.

PubMed

Reppucci, Marina L; Schleien, Charles L; Fish, Jonathan D

2017-02-01

Childhood cancer survivors (CCSs) are at high risk of morbidity and mortality from long-term complications of their cancer treatment. The Children's Oncology Group developed screening guidelines to enable the early identification of and intervention for late effects of cancer treatment. There is a paucity of data on the adherence of CCSs to screening recommendations. A retrospective analysis of medical records to evaluate the rate of adherence of CCSs to the personalized, risk-based recommendations provided to them in the context of a structured long-term follow-up program over a 3-year period. Two hundred eighty-six CCSs visited the survivorship clinic 542 times during the 3-year study period. The overall rate of adherence to recommended screening was 74.2%. Using a univariate model and greater age at diagnosis and at screening recommendation were associated with decreased screening adherence. Gender, cancer diagnosis, radiation therapy, anthracycline exposure, and hematopoietic stem cell transplant were not significantly associated with adherence. In a multivariate model, age over 18 years at the time of the visit was significantly associated with decreased adherence (P < 0.0329) (odds ratio: 1.53, 95% confidence interval: 1.04-2.25). Adherence to recommended screening tests is suboptimal among CCSs, with lower rates of adherence in CCSs older than 18 years of age compared with those younger than 18 years of age. Given the morbidity and mortality from the late effects of therapy among young adult CCSs, it is critically important to identify and remove barriers to late-effects screening among CCSs. © 2016 Wiley Periodicals, Inc.

Supporting long-term follow-up of young adult survivors of childhood cancer: Correlates of healthcare self-efficacy.

PubMed

Miller, Kimberly A; Wojcik, Katherine Y; Ramirez, Cynthia N; Ritt-Olson, Anamara; Freyer, David R; Hamilton, Ann S; Milam, Joel E

2017-02-01

Healthcare self-efficacy (HCSE), the perceived confidence to manage one's health care, has been identified as a critical component in the transition process from pediatric to adult-oriented care for childhood cancer survivors (CCSs). HCSE is amenable to intervention and associated with long-term follow-up care among CCSs. However, factors associated with HCSE have not been fully explored among CCSs. We identified correlates of HCSE among a sample of CCSs (n = 193). Descriptive statistics and linear regression methods were used in this cross-sectional analysis. In univariate analyses, higher physical and psychosocial quality of life, posttraumatic growth, and religious/spiritual importance were associated with higher HCSE. Attendance at a survivorship clinic, having a regular source of care (both noncancer and oncologist), and any type of health insurance were also associated with HCSE. Hispanic ethnicity was negatively associated with HCSE relative to non-Hispanics. In a multivariable model, psychosocial quality of life, religious/spiritual importance, survivorship clinic attendance, having a regular oncologist, and Hispanic ethnicity remained significantly associated with HCSE. CCSs who reported greater well-being, who rated religion and spirituality of high importance, and who accessed specialized cancer services expressed greater HCSE. Hispanic CCSs, however, reported less HCSE than non-Hispanics. Interventions that attend to the quality of life and spiritual needs of CCSs have potential to build HCSE to support the healthcare transition process. Because Hispanic CCSs may be at risk of lower perceived confidence to navigate their health care, culturally competent, efficacy-enhancing interventions are needed for this population. © 2016 Wiley Periodicals, Inc.

Effect of Web-Based Versus Paper-Based Questionnaires and Follow-Up Strategies on Participation Rates of Dutch Childhood Cancer Survivors: A Randomized Controlled Trial

PubMed Central

van Dulmen-den Broeder, Eline; van der Pal, Helena J; Hollema, Nynke; Kremer, Leontien C; van den Heuvel-Eibrink, Marry M; van Leeuwen, Flora E

2015-01-01

Background Questionnaires are widely used in survey research, especially in cohort studies. However, participation in questionnaire studies has been declining over the past decades. Because high participation rates are needed to limit the risk of selection bias and produce valid results, it is important to investigate invitation strategies which may improve participation. Objectives The purpose of this study is to investigate the effect of Web-based versus paper-based questionnaires on participation rates in a questionnaire survey on late effects among childhood cancer survivors (CCSs). Methods A total of 750 CCSs were randomized across 3 study arms. The initial invitation in study arms 1 and 2 consisted of a Web-based questionnaire only, whereas in study arm 3 this invitation was complemented with a paper-based version of the questionnaire. The first postal reminder, sent to the nonresponding CCSs in all 3 study arms, consisted of either a reminder letter only (study arms 1 and 3) or a reminder letter complemented with a paper-based questionnaire (study arm 2). The second postal reminder was restricted to CCSs in study arms 1 and 2, with only those in study arm 1 also receiving a paper-based questionnaire. CCSs in study arm 3 received a second reminder by telephone instead of by mail. In contrast to CCSs in study arm 3, CCSs in study arms 1 and 2 received a third reminder, this time by telephone. Results: Overall, 58.1% (436/750) of the CCSs participated in the survey. Participation rates were equal in all 3 study arms with 57.4% (143/249) in arm 1, 60.6% (152/251) in arm 2, and 56.4% (141/250) in arm 3 (P=.09). Participation rates of CCSs who received an initial invitation for the Web-based questionnaire only and CCSs who received an invitation to complete either a paper-based or Web-based questionnaire did not differ (P=.55). After the first postal reminder, participation rates of CCSs invited for the Web-based questionnaire only also did not differ compared with CCSs invited for both the Web-based and paper-based questionnaires (P=.48). In general, CCSs preferred the paper-based over the Web-based questionnaire, and those completing the paper-based questionnaire were more often unemployed (P=.004) and lower educated (P<.001). Conclusion Invitation strategies offering a Web-based questionnaire without a paper-based alternative at first invitation can be used without compromising participation rates of CCS. Offering the choice between paper- and Web-based questionnaires seems to result in the highest accrual participation rate. Future research should look into the quality of the data delivered by both questionnaires filled in by respondents themselves. Trial Registration International Standard Randomized Controlled Trial Number (ISRCTN): 84711754; http://www.controlled-trials.com/ISRCTN84711754 (Archived by WebCite at http://www.webcitation.org/6c9ZB8paX) PMID:28410161

The Art of Questions: Inquiry, the CCSS, and School Librarians

ERIC Educational Resources Information Center

Wadham, Rachel

2013-01-01

This article examines the association among inquiry, the Common Core State Standards (CCSS) and school librarians. It explains the significance of asking questions, and describes the characteristics of the questions that are central to inquiry learning. The role of school librarians in inquiry learning and the implementation of CCSS is also…

Performance and Operational Characteristics for a Dual Brayton Space Power System With Common Gas Inventory

NASA Technical Reports Server (NTRS)

Johnson, Paul K.; Mason, Lee S.

2006-01-01

This paper provides an analytical evaluation on the operation and performance of a dual Brayton common gas system. The NASA Glenn Research Center in-house computer program Closed Cycle System Simulation (CCSS) was used to construct a model of two identical 50 kWe-class recuperated closed-Brayton-cycle (CBC) power conversion units that share a common gas inventory and single heat source. As operating conditions for each CBC change, the total gas inventory is redistributed between the two units and overall system performance is affected. Several steady-state off-design operating points were analyzed by varying turbine inlet temperature and turbo-alternator shaft rotational speed to investigate the interaction of the two units.

Social outcomes and quality of life of childhood cancer survivors in Japan: a cross-sectional study on marriage, education, employment and health-related QOL (SF-36).

PubMed

Ishida, Yasushi; Honda, Misato; Kamibeppu, Kiyoko; Ozono, Shuichi; Okamura, Jun; Asami, Keiko; Maeda, Naoko; Sakamoto, Naoko; Inada, Hiroko; Iwai, Tsuyako; Kakee, Naoko; Horibe, Keizo

2011-05-01

Social outcomes and quality of life (QOL) of childhood cancer survivors (CCSs) remain unknown in Japan. We investigated these outcomes in young adult CCSs compared to those of their siblings in Japan, and analyzed the association between social outcome and SF-36 health survey subscale scores. Between 2007 and 2009, we performed a cross-sectional survey using self-rating questionnaires. We estimated social outcomes and health-related QOL by performing the SF-36 in each group: CCSs with or without stem cell transplantation (SCT)/radiotherapy (RT) and their siblings. Adjusted odds ratios for outcomes of interest were estimated using logistic regression analysis. Questionnaires from 185 CCSs and 72 CCS's siblings were analyzed. There were no differences in educational attainment or annual income. The SF-36 subscale scores of CCSs with SCT and RT were significantly lower than those of siblings in physical functioning (PF) (p < 0.001 and 0.003, respectively) and general health (GH) (both p = 0.001). Lower PF scores correlated with recurrence (p = 0.041) and late effects (p = 0.010), and poor GH scores with late effects (p = 0.006). The CCSs had made efforts to attain educational/vocational goals; however, a significant proportion of CCSs who had experienced late effects remain at increased risk of experiencing diminished QOL.

Relations between the CCSS and RTI in Literacy and Language

ERIC Educational Resources Information Center

Wixson, Karen K.; Lipson, Marjorie Y.

2012-01-01

Initiatives such as Response to Intervention (RTI) and the Common Core State Standards for English Language Arts (CCSS-ELA) have the potential to positively impact progress toward the goal of literacy for all. Because the CCSS-ELA will guide the content of the curriculum, instruction and assessment in the large number of adopting states, they will…

Writing "Voiced" Arguments about Science Topics: Answering the CCSS Call for Integrated Literacy Instruction

ERIC Educational Resources Information Center

Monahan, Mary Beth

2013-01-01

This teacher-research study responds to the Common Core State Standards (CCSS) call for an integrated model of literacy that simultaneously builds deep content knowledge and develops students' proficiency in writing arguments in science. The author notes that while argument is a cornerstone of the CCSS writing standards, little attention is…

Getting College-Ready during State Transition toward the Common Core State Standards

ERIC Educational Resources Information Center

Xu, Zeyu; Cepa, Kennan

2018-01-01

Background: As of 2016, 42 states and the District of Columbia have adopted the Common Core State Standards (CCSS). Tens of millions of students across the country completed high school before their schools were able to fully implement the CCSS. As with previous standards-based reforms, the transition to the CCSS-aligned state education standards…

Implementation of Common Core State Standards: Roles for Advocates

ERIC Educational Resources Information Center

Haycock, Kati

2012-01-01

Forty-six states and the District of Columbia have committed to fully implement the Common Core State Standards (CCSS) by the fall of 2013, and members of the two CCSS-aligned assessment consortia have committed to roll out an aligned assessment the following year. With less than a year until the CCSS must be in place in all classrooms, most…

The Common Core and Democratic Education: Examining Potential Costs and Benefits to Public and Private Autonomy

ERIC Educational Resources Information Center

Bindewald, Benjamin J.; Tannebaum, Rory P.; Womac, Patrick

2016-01-01

This conceptual paper assesses prevalent critiques of the Common Core State Standards (CCSS) and analyzes content from the CCSS in language arts and literacy to determine whether the standards are likely to support or undermine key democratic aims of education. The authors conclude that critiques of the CCSS have some merit but are generally…

Mental health among young adult survivors of childhood cancer and their siblings including posttraumatic growth.

PubMed

Kamibeppu, Kiyoko; Sato, Iori; Honda, Misato; Ozono, Shuichi; Sakamoto, Naoko; Iwai, Tsuyako; Okamura, Jun; Asami, Keiko; Maeda, Naoko; Inada, Hiroko; Kakee, Naoko; Horibe, Keizo; Ishida, Yasushi

2010-12-01

Few studies have addressed the mental health status of young adult childhood cancer survivors (CCSs) and their siblings (SIBs). This paper focuses on depression, anxiety, posttraumatic stress symptoms (PTSS), and posttraumatic growth (PTG) among Japanese CCSs and their SIBs. Adolescent and young adult CCSs (n=185), in remission for more than 1 year, their SIBs (n=72), and general controls (CONTs) (n=1,000) completed anonymous self-report questionnaires for depression, anxiety, PTSS, and PTG. The physicians in charge also completed an anonymous disease/treatment data sheet. CCSs were approximately 8 years old at diagnosis and approximately 23 years old at the time of the survey. Their diagnoses included leukemia (57%), lymphoma (12%), and solid tumors (30%). Thirty-eight percent underwent surgery and 25% received stem cell transplantation. No significant differences were found between CCSs and CONTs in terms of depression and anxiety. CCSs had significantly more PTSS and had remarkably greater PTG compared to CONTs. Although no significant differences were found between SIBs and CONTs regarding depression, anxiety, or PTSS, female SIBs exhibited greater PTG compared to female CONTs. To empower CCSs, they should be evaluated periodically regarding PTSS and PTG and should be provided appropriate care and feedback. The fact that the mental health status of young adult SIBs was similar to CONTs at 15 years after their siblings' diagnoses may help reassure parents who worry about mental health among the siblings of an affected child during and after his/her treatment.

On the Frontline of CCSS Implementation: A National Study of Factors Influencing Teachers' Perceptions of Teaching Conditions and Job Satisfaction

ERIC Educational Resources Information Center

Endacott, Jason L.; Collet, Vicki; Goering, Christian Z.; Turner, Ronna; Denny, George S.; Wright, Ginney; Jennings-Davis, Jennifer

2016-01-01

The Common Core State Standards (CCSS) represent an unprecedented change in American education. As an increasingly integral part of the school accountability movement under No Child Left Behind and Race to the Top, responsibility for implementing CCSS rests largely with school leadership. One important factor in the success or failure of these…

easyCBM CCSS Math Item Scaling and Test Form Revision (2012-2013): Grades 6-8. Technical Report #1313

ERIC Educational Resources Information Center

Anderson, Daniel; Alonzo, Julie; Tindal, Gerald

2012-01-01

The purpose of this technical report is to document the piloting and scaling of new easyCBM mathematics test items aligned with the Common Core State Standards (CCSS) and to describe the process used to revise and supplement the 2012 research version easyCBM CCSS math tests in Grades 6-8. For all operational 2012 research version test forms (10…

Study of the Reliability of CCSS-Aligned Math Measures (2012 Research Version): Grades 6-8. Technical Report #1312

ERIC Educational Resources Information Center

Anderson, Daniel; Alonzo, Julie; Tindal, Gerald

2012-01-01

In this technical report, we describe the results of a study of mathematics items written to align with the Common Core State Standards (CCSS) in grades 6-8. In each grade, CCSS items were organized into forms, and the reliability of these forms was evaluated along with an experimental form including items aligned with the National Council of…

A Study of the Alignment between the NAEP Mathematics Framework and the Common Core State Standards for Mathematics (CCSS-M)

ERIC Educational Resources Information Center

Hughes, Gerunda B.; Daro, Phil; Holtzman, Deborah; Middleton, Kyndra

2013-01-01

Introduction: For decades, prior to the inception of the Common Core State Standards (CCSS), the National Assessment of Educational Progress (NAEP) was the only vehicle through which states could assess the progress of their students using a common metric. Now, 45 states, 4 U.S. territories, and the District of Columbia have adopted the CCSS to…

Techies, the Tea Party, and the Race to the Top: The Rise of the New Upper-Middle Class and Tensions in the Rightist Politics of Federal Education Reform

ERIC Educational Resources Information Center

Au, Wayne

2016-01-01

The Common Core State Standards (CCSS) and their associated high-stakes testing are key parts of the federal Race to the Top (RTTT) initiative. There has been considerable resistance to both CCSS and related testing, particularly from conservative actors. This resistance suggests that CCSS has caused substantial tension within the conservative…

β-arrestin drives MAP kinase signaling from clathrin-coated structures after GPCR dissociation

PubMed Central

Eichel, K.; Jullié, D.

2016-01-01

β-arrestins critically regulate G protein-coupled receptor (GPCR) signaling, not only 'arresting' the G protein signal but also modulating endocytosis and initiating a discrete G protein-independent signal via MAP kinase1–3. Despite enormous recent progress toward understanding biophysical aspects of arrestin function4,5, its cell biology remains relatively poorly understood. Two key tenets underlie the present dogma: (1) β-arrestin accumulates in clathrin-coated structures (CCSs) exclusively in physical complex with its activating GPCR, and (2) MAP kinase activation requires endocytosis of formed GPCR - β-arrestin complexes6–9. We show here, using β1-adrenergic receptors, that β-arrestin-2 (Arrestin 3) accumulates robustly in CCSs after dissociating from its activating GPCR and transduces the MAP kinase signal from CCSs. Moreover, inhibiting subsequent endocytosis of CCSs enhances the clathrin and β-arrestin -dependent MAP kinase signal. These results demonstrate β-arrestin 'activation at a distance', after dissociating from its activating GPCR, and signaling from CCSs. We propose a β-arrestin signaling cycle that is catalytically activated by the GPCR and energetically coupled to the endocytic machinery. PMID:26829388

Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy.

PubMed

Teepen, Jop C; van Leeuwen, Flora E; Tissing, Wim J; van Dulmen-den Broeder, Eline; van den Heuvel-Eibrink, Marry M; van der Pal, Helena J; Loonen, Jacqueline J; Bresters, Dorine; Versluys, Birgitta; Neggers, Sebastian J C M M; Jaspers, Monique W M; Hauptmann, Michael; van der Heiden-van der Loo, Margriet; Visser, Otto; Kremer, Leontien C M; Ronckers, Cécile M

2017-07-10

Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term risk of SMNs in a well-characterized cohort of 5-year CCSs, with a particular focus on individual chemotherapeutic agents and solid cancer risk. Methods The Dutch Childhood Cancer Oncology Group-Long-Term Effects After Childhood Cancer cohort includes 6,165 5-year CCSs diagnosed between 1963 and 2001 in the Netherlands. SMNs were identified by linkages with the Netherlands Cancer Registry, the Dutch Pathology Registry, and medical chart review. We calculated standardized incidence ratios, excess absolute risks, and cumulative incidences. Multivariable Cox proportional hazard regression analyses were used to evaluate treatment-associated risks for breast cancer, sarcoma, and all solid cancers. Results After a median follow-up of 20.7 years (range, 5.0 to 49.8 years) since first diagnosis, 291 SMNs were ascertained in 261 CCSs (standardized incidence ratio, 5.2; 95% CI, 4.6 to 5.8; excess absolute risk, 20.3/10,000 person-years). Cumulative SMN incidence at 25 years after first diagnosis was 3.9% (95% CI, 3.4% to 4.6%) and did not change noticeably among CCSs treated in the 1990s compared with those treated earlier. We found dose-dependent doxorubicin-related increased risks of all solid cancers ( P trend < .001) and breast cancer ( P trend < .001). The doxorubicin-breast cancer dose response was stronger in survivors of Li-Fraumeni syndrome-associated childhood cancers (leukemia, CNS, and non-Ewing sarcoma) versus survivors of other cancers ( P difference = .008). In addition, cyclophosphamide was found to increase sarcoma risk in a dose-dependent manner ( P trend = .01). Conclusion The results strongly suggest that doxorubicin exposure in CCSs increases the risk of subsequent solid cancers and breast cancer, whereas cyclophosphamide exposure increases the risk of subsequent sarcomas. These results may inform future childhood cancer treatment protocols and SMN surveillance guidelines for CCSs.

High-latitude Conic Current Sheets in the Solar Wind

NASA Astrophysics Data System (ADS)

Khabarova, Olga V.; Malova, Helmi V.; Kislov, Roman A.; Zelenyi, Lev M.; Obridko, Vladimir N.; Kharshiladze, Alexander F.; Tokumaru, Munetoshi; Sokół, Justyna M.; Grzedzielski, Stan; Fujiki, Ken'ichi

2017-02-01

We provide observational evidence for the existence of large-scale cylindrical (or conic-like) current sheets (CCSs) at high heliolatitudes. Long-lived CCSs were detected by Ulysses during its passages over the South Solar Pole in 1994 and 2007. The characteristic scale of these tornado-like structures is several times less than a typical width of coronal holes within which the CCSs are observed. CCS crossings are characterized by a dramatic decrease in the solar wind speed and plasma beta typical for predicted profiles of CCSs. Ulysses crossed the same CCS at different heliolatitudes at 2-3 au several times in 1994, as the CCS was declined from the rotation axis and corotated with the Sun. In 2007, a CCS was detected directly over the South Pole, and its structure was strongly highlighted by the interaction with comet McNaught. Restorations of solar coronal magnetic field lines reveal the occurrence of conic-like magnetic separators over the solar poles in both 1994 and 2007. Such separators exist only during solar minima. Interplanetary scintillation data analysis confirms the presence of long-lived low-speed regions surrounded by the typical polar high-speed solar wind in solar minima. Energetic particle flux enhancements up to several MeV/nuc are observed at edges of the CCSs. We built simple MHD models of a CCS to illustrate its key features. The CCSs may be formed as a result of nonaxiality of the solar rotation axis and magnetic axis, as predicted by the Fisk-Parker hybrid heliospheric magnetic field model in the modification of Burger and coworkers.

High-latitude Conic Current Sheets in the Solar Wind

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khabarova, Olga V.; Obridko, Vladimir N.; Kharshiladze, Alexander F.

We provide observational evidence for the existence of large-scale cylindrical (or conic-like) current sheets (CCSs) at high heliolatitudes. Long-lived CCSs were detected by Ulysses during its passages over the South Solar Pole in 1994 and 2007. The characteristic scale of these tornado-like structures is several times less than a typical width of coronal holes within which the CCSs are observed. CCS crossings are characterized by a dramatic decrease in the solar wind speed and plasma beta typical for predicted profiles of CCSs. Ulysses crossed the same CCS at different heliolatitudes at 2–3 au several times in 1994, as the CCSmore » was declined from the rotation axis and corotated with the Sun. In 2007, a CCS was detected directly over the South Pole, and its structure was strongly highlighted by the interaction with comet McNaught. Restorations of solar coronal magnetic field lines reveal the occurrence of conic-like magnetic separators over the solar poles in both 1994 and 2007. Such separators exist only during solar minima. Interplanetary scintillation data analysis confirms the presence of long-lived low-speed regions surrounded by the typical polar high-speed solar wind in solar minima. Energetic particle flux enhancements up to several MeV/ nuc are observed at edges of the CCSs. We built simple MHD models of a CCS to illustrate its key features. The CCSs may be formed as a result of nonaxiality of the solar rotation axis and magnetic axis, as predicted by the Fisk–Parker hybrid heliospheric magnetic field model in the modification of Burger and coworkers.« less

Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies.

PubMed

Shaheen, Naim; Shiti, Assad; Huber, Irit; Shinnawi, Rami; Arbel, Gil; Gepstein, Amira; Setter, Noga; Goldfracht, Idit; Gruber, Amit; Chorna, Snizhanna V; Gepstein, Lior

2018-06-05

Fulfilling the potential of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes for studying conduction and arrhythmogenesis requires development of multicellular models and methods for long-term repeated tissue phenotyping. We generated confluent hiPSC-derived cardiac cell sheets (hiPSC-CCSs), expressing the genetically encoded voltage indicator ArcLight. ArcLight-based optical mapping allowed generation of activation and action-potential duration (APD) maps, which were validated by mapping the same hiPSC-CCSs with the voltage-sensitive dye, Di-4-ANBDQBS. ArcLight mapping allowed long-term assessment of electrical remodeling in the hiPSC-CCSs and evaluation of drug-induced conduction slowing (carbenoxolone, lidocaine, and quinidine) and APD prolongation (quinidine and dofetilide). The latter studies also enabled step-by-step depiction of drug-induced arrhythmogenesis ("torsades de pointes in the culture dish") and its prevention by MgSO 4 and rapid pacing. Phase-mapping analysis allowed biophysical characterization of spiral waves induced in the hiPSC-CCSs and their termination by electrical cardioversion and overdrive pacing. In conclusion, ArcLight mapping of hiPSC-CCSs provides a powerful tool for drug testing and arrhythmia investigation. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

High-Quality Science Instruction: Building Conceptual Understanding and Language Skills for English Learners

ERIC Educational Resources Information Center

DiRanna, Kathy; Gomez-Zwiep, Susan

2013-01-01

The confluence of "Common Core State Standards" ("CCSS"), "Next Generation Science Standards" ("NGSS"), and 21st century skills provides an unparalleled opportunity to improve science, technology, engineering, and mathematics (STEM) education for all students, particularly English learners. "CCSS,"…

Prevalence of cardiovascular risk factors in long-term survivors of childhood cancer: 16 years follow up from a prospective registry.

PubMed

Felicetti, Francesco; D'Ascenzo, Fabrizio; Moretti, Claudio; Corrias, Andrea; Omedè, Pierluigi; Marra, Walter Grosso; Arvat, Emanuela; Fagioli, Franca; Brignardello, Enrico; Gaita, Fiorenzo

2015-06-01

Childhood cancer survivors (CCSs) have an increased risk of overweight and dyslipidaemia, but the distribution and the potential relationships between anticancer therapies and cardiovascular risk factors have been heterogeneously and not prospectively described. All consecutive CCSs with primary cancer diagnosed between 1973-2007 and subsequently referred to our outpatient clinic were enrolled. Hypercholesterolaemia (total cholesterol >200 and/or low density lipoprotein (LDL)>160 mg/dl) was the primary end point, hypertriglyceridaemia (triglycerides >200 mg/dl) and body mass index >30 kg/m(2) the secondary end points. Cox multivariate adjustments were performed to account for differences in cancer and treatments. A total of 340 patients were included (197 male, 143 female; mean age at last follow-up 24.1 ± 3.2). The most common diagnosis were haematological malignancies (n = 227) and brain tumours (n = 51). After a median follow-up of 16.1 years, hypercholesterolaemia was diagnosed in 67 CCSs (20%), hypertriglyceridaemia in 20 CCSs (6%) and obesity in 28 CCSs (8%). Total body irradiation and growth hormone deficiency increased the risk of both hypercholesterolaemia (hazard ratio (HR) = 2.7; confidence interval (CI) 1.2-4.4 and HR = 2.3; CI 1.1-4.9; all p < 0.05) and hypertriglyceridaemia (HR = 6.5; CI 1.4-31 and HR = 7.2; CI 1.1-43; all p < 0.05). The risk of hypercholesterolaemia was also higher in CCSs who underwent autologous haematopoietic stem cell transplantation (HR = 3.2; CI 1.7-5.9; p < 0.001) or platinum-based chemotherapy (HR = 2.7; CI 1.5-4.9; p < 0.001), whereas a previous diagnosis of brain tumour (HR = 10; CI 1.2-45; p < 0.05) and anthracyclines exposure (HR = 1.3; CI 1.2-26; p < 0.05) significantly predicted obesity. CCSs show a high and variable risk for developing dyslipidaemia and obesity, depending on cancer diagnosis and treatments. Therefore, they need accurate and tailored control of their cardiovascular risk profile. © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Informational Text and the CCSS

ERIC Educational Resources Information Center

Aspen Institute, 2012

2012-01-01

What constitutes an informational text covers a broad swath of different types of texts. Biographies & memoirs, speeches, opinion pieces & argumentative essays, and historical, scientific or technical accounts of a non-narrative nature are all included in what the Common Core State Standards (CCSS) envisions as informational text. Also included…

Are California's Schools Ready for Online Testing and Learning?

ERIC Educational Resources Information Center

Gao, Niu

2015-01-01

In addition to the Common Core State Standards (CCSS), California is implementing a new, online assessment system: the California Assessment of Student Performance and Progress (CAASPP). Field tests were conducted last spring and the system is being rolled out this year, amid concerns about whether schools are technologically prepared. Using…

Common Core State Standards and Adaptive Teaching

ERIC Educational Resources Information Center

Kamil, Michael L.

2016-01-01

This article examines the issues of how Common Core State Standards (CCSS) will impact adaptive teaching. It focuses on 2 of the major differences between conventional standards and CCSS: the increased complexity of text and the addition of disciplinary literacy standards to reading instruction. The article argues that adaptive teaching under CCSS…

Robots Teaching Other Little Robots: Neoliberalism, CCSS, and Teacher Professionalism

ERIC Educational Resources Information Center

Endacott, Jason L.; Wright, Ginney P.; Goering, Christian Z.; Collet, Vicki S.; Denny, George S.; Davis, Jennifer Jennings

2015-01-01

Recent quantitative research on the implementation of the Common Core State Standards (CCSS) in schools across Arkansas has discovered that teachers' perceptions of job satisfaction, agency, and professionalism are significantly affected by their school leaders' openness towards autonomy, flexibility, and opinions of teachers (Matlock et al.…

Literacy Instruction in the Wake of Common Core State Standards

ERIC Educational Resources Information Center

Barrett-Mynes, Jennifer

2013-01-01

As teachers modify their instruction to meet English Language Arts (ELA) Common Core State Standards (CCSS), how do these modifications influence literacy instruction and learning opportunities afforded to students? While the CCSS standardized objectives for literacy instruction, the enacted curriculum is uniquely shaped by teachers and their…

Sharing Complex Text and the CCSS

ERIC Educational Resources Information Center

Aspen Institute, 2012

2012-01-01

The Common Core State Standards (CCSS) fulfill a longstanding goal of ensuring that all students, regardless of ability, are college and career ready upon graduation. Students who meet the expectations of the standards are able to comprehend complex text closely and extract meaning and information from it. They are close readers, delving into…

Dissect, Design, and Customize the Curriculum

ERIC Educational Resources Information Center

Tienken, Christopher H.

2013-01-01

Education bureaucrats in 45 states have approved the Common Core State Standards ([CCSS], 2010) as the de facto national curriculum. The implementation of the CCSS will be monitored by a national standardized test in language arts and mathematics. The confluence of a standardized curriculum enforced with a standardized test will entrench a…

Common Core Teaching Strategics in the Inclusive Classroom

ERIC Educational Resources Information Center

Beggs, Sara

2017-01-01

In this qualitative case study, intersectionality of strategies for teaching in an inclusive classroom with students with disabilities and strategies for teaching the Common Core State Standards (CCSS) will be explored. A gap in the literature demonstrated a need for further research in the area of CCSS for students with disabilities and more…

REASON: A Self-Instruction Strategy for Twice-Exceptional Learners Struggling With Common Core Mathematics

ERIC Educational Resources Information Center

Van Boxtel, Joanne M.

2016-01-01

Educators across the nation are now well under way in implementing the Common Core State Standards (CCSS; National Governors Association Center for Best Practices & Council of Chief State School Officers [NGA & CCSSO], 2010) for mathematics. The emerging literature regarding CCSS mathematics instruction for students with disabilities urges…

A New Look at Information Books

ERIC Educational Resources Information Center

Weisman, Kay

2012-01-01

With the widespread adoption of the Common Core State Standards (CCSS), classroom use of information texts is increasing. CCSS mandate an emphasis on the use of these texts so that students become adept at reading and comprehending complex information in order to write compelling arguments. Students are encouraged to read, write, and engage in…

Catching up to the CCSS: A Principal Navigates Out-of-Subject Instructional Leadership

ERIC Educational Resources Information Center

Quebec Fuentes, Sarah; Switzer, J. Matt; Jimerson, Jo Beth

2015-01-01

This case provides principals and principal licensure candidates an opportunity to delve into the nuances of supervising teachers in content areas, which may be unfamiliar, and to explore strategies for increasing knowledge about the structures and emphases of the "Common Core State Standards" (CCSS). The case presents issues related to…

Information Fuels Support for School Reform

ERIC Educational Resources Information Center

Henderson, Michael B.; Howell, William G.; Peterson, Paul E.

2014-01-01

The Common Core State Standards initiative (CCSS) seeks to "provide a consistent, clear understanding of what students are expected to learn" at various grade levels. For some education observers, CCSS will finally clarify for students, parents, and educators what students need to know and be able to do if they are to be prepared for…

Student Reading Growth Illuminates the Common Core Text-Complexity Standard: Raising Both Bars

ERIC Educational Resources Information Center

Williamson, Gary L.; Fitzgerald, Jill; Stenner, Jackson A.

2014-01-01

The Common Core State Standards (CCSS) establish a challenging text-complexity standard for all high school graduates to read at college and workplace text-complexity levels. We argue that implementation of the CCSS standard requires concurrent examination of historical student reading-growth trends. An example of a historical student average…

The Role of District Office Leaders in the Adoption and Implementation of the Common Core State Standards in Elementary Schools

ERIC Educational Resources Information Center

Durand, Francesca T.; Lawson, Hal A.; Wilcox, Kristen Campbell; Schiller, Kathryn S.

2016-01-01

Purpose: This multiple case study investigated district leaders' orientations and strategies as their elementary schools proceeded with state-mandated implementation of the Common Core State Standards (CCSS). We identified differences between schools achieving above-predicted outcomes on state CCSS assessments ("odds-beaters") and…

English Language Learner Teacher Effectiveness and the Common Core

ERIC Educational Resources Information Center

Johnson, Tammy; Wells, Lorra

2017-01-01

Common Core State Standards (CCSS) and teacher effectiveness are among the most contentious issues in education today. With an increase in English language learners (ELLs) and the rigorous requirements imposed by the CCSS, teachers are left unprepared and ELLs struggle to stay afloat. Using California as a case study, this research synthesis…

Nonfiction Book Apps: Addressing CCSS and Engaging Students

ERIC Educational Resources Information Center

Potter, Cathy; Scheuer, Mary Ann

2013-01-01

As schools around the country implement the Common Core State Standards (CCSS), teachers and school librarians are looking for ways to incorporate more engaging nonfiction reading. The quantity of informational texts students will be required to read will increase drastically, and students will be asked to apply higher-level thinking skills to…

Assessing Academic Language in an Elementary Mathematics Teacher Licensure Exam

ERIC Educational Resources Information Center

Castellano, Katherine E.; Duckor, Brent; Wihardini, Diah; Telléz, Kip; Wilson, Mark

2016-01-01

With the adoption by most states of the Common Core State Standards (CCSS) for English language arts and literacy and for mathematics (CCSS Initiative, 2010a, 2010b) comes major changes in public education that will affect instructional practice, curriculum, and assessment across the nation. Heritage, Walqui, and Linquanti (2015) argued that the…

Responding to the CCSS for Literacy Research and Instruction

ERIC Educational Resources Information Center

Mandel Morrow, Lesley; Kunz, Kenneth

2016-01-01

In "Beyond the Common Core: Examining 20 Years of Literacy Priorities and Their Impact on Struggling Readers," Cassidy et al. (2016) suggest that the emphasis on the Common Core State Standards (CCSS, National Governors Association [NGA] Center for Best Practices and Council of Chief State School Officers [CCSSO], 2010) has had…

Common Core Expertise for Special Education Teachers: What Do Special Education Administrators Think Is Important?

ERIC Educational Resources Information Center

Van Boxtel, Joanne M.

2017-01-01

The Common Core State Standards (CCSS) have been described as the next chapter in American education with the promise to deliver "fewer, clearer, and higher" standards aimed at preparing "all" students for college "and" career (Rothman, 2013). Though CCSS articulates minimum expectations for what college and…

Understanding the Skills in the Common Core State Standards

ERIC Educational Resources Information Center

Blosveren, Kate

2012-01-01

As defined on the Common Core State Standards (CCSS) website, "the Common Core State Standards provide a consistent, clear understanding of what students are expected to learn... reflecting the "knowledge" and "skills" that our young people need for success in college and careers." While the "knowledge" defined within the CCSS is apparent--the…

Text Dependent Questions and the CCSS

ERIC Educational Resources Information Center

Aspen Institute, 2012

2012-01-01

An effective text dependent question first and foremost embraces the key principle of close reading embedded in the Common Core State Standards (CCSS) Anchor Reading Standards by asking students to provide evidence from complex text and draw inferences based on what the text explicitly says (Standards 1 and 10). A close look at the intervening…

Why Historical Fiction Writing? Helping Students Think Rigorously and Creatively

ERIC Educational Resources Information Center

Hughes, Ryan

2013-01-01

The Common Core State Standards (CCSS) lays out "a vision of what it means to be a literate person in the twenty-first century." Among educators, conversations about reading and writing have shifted to reflect the CCSS emphasis on informational, technical, opinion, and other non-narrative forms. Yet, these standards also demand that…

Educators' Perceptions and Knowledge of the Common Core State Standards

ERIC Educational Resources Information Center

Nadelson, Louis S.; Pluska, Heidi; Moorcroft, Scott; Jeffrey, Annie; Woodard, Susan

2014-01-01

As with many previous K-12 educational reform efforts, expectations that the Common Core State Standards (CCSS; National Governors Association Center for Best Practices, 2010) will assist students in learning so that they can prepare for college and the workforce are very high (American College Testing, 2012). Briefly, the CCSS "are designed…

Teachers' Perceptions on Preparedness and Supports to Implement the English Language Arts Common Core State Standards

ERIC Educational Resources Information Center

Fernandez, Maria Clara

2017-01-01

The purpose of this study was to: (1) describe elementary teachers' perceptions on their preparedness to implement the English Language Arts Common Core State Standards (ELA-CCSS); (2) determine how perceptions influenced changes in instructional practices; and (3) to explore ELA-CCSS implementation challenges and/or barriers in supporting teacher…

Integrating the English Language Arts Common Core State Standards into Physical Education

ERIC Educational Resources Information Center

James, Alisa R.; Bullock, Kerri

2015-01-01

Physical education teachers are expected to implement the English language arts (ELA) Common Core State Standards (CCSS) in their instruction. This has proved to be challenging for many physical educators. The purpose of this article is to provide developmentally appropriate examples of how to incorporate the ELA CCSS into physical education,…

Crosswalk Analysis of Deeper Learning Skills to Common Core State Standards

ERIC Educational Resources Information Center

Conley, David T.

2011-01-01

The Educational Policy Improvement Center (EPIC) conducted a crosswalk between the Deeper Learning Skills (DLS) and the Common Core State Standards (CCSS). The purpose of the crosswalk was to understand the ways in which strategies for deeper learning relate to the CCSS. This comparison was not solely or simply an alignment study, although some…

STEM Education on a Worldwide Voyage: Curriculum to College, Career, and Community Readiness

ERIC Educational Resources Information Center

Furuto, Linda H. L.

2015-01-01

This article addresses issues in equitable and quality STEM education, and comes at a significant time as students, educators, and policymakers strive to meet federal and state standards such as the Mathematics Common Core State Standards (CCSS) and Next Generation Science Standards (NGSS). CCSS and NGSS require significantly higher levels of…

Surprising Strengths and Substantial Needs: Rural District Implementation of Common Core State Standards

ERIC Educational Resources Information Center

Timar, Thomas; Carter, Allison

2017-01-01

In August 2010, the California State Board of Education adopted the Common Core State Standards (CCSS). Three years later, the president of the State Board, Dr. Michael Kirst, noted that CCSS "changes almost everything," including what teachers teach, how they teach, and what students are expected to learn (Kirst, 2013). Echoing his…

Common Core State Standards for Students with Gifts and Talents

ERIC Educational Resources Information Center

VanTassel-Baska, Joyce

2015-01-01

As many states have adopted the Common Core State Standards (CCSS), teachers can look to these standards as a framework for supporting students with gifts and talents. Differentiation of curriculum and instruction to address the CCSS will be necessary to meet the unique learning needs of learners with high ability and those with gifts and talents.…

Common Core Preparation in Special Education Teacher Education Programs: Beginning the Conversation

ERIC Educational Resources Information Center

Murphy, Michelle R.; Marshall, Kathleen J.

2015-01-01

The Common Core State Standards (CCSS) were developed to encourage a common focus of instruction and evaluation in the areas of mathematics, reading/language arts, writing, speaking, and listening. As of 2011, all but five states have adopted CCSS for math and English Language Arts (ELA), with another adopting only the standards for ELA. With…

Dialogism: Feminist Revision of Argumentative Writing Instruction

ERIC Educational Resources Information Center

Kerkhoff, Shea N.

2015-01-01

According to the Common Core State Standards (CCSS), to be college and career ready students must be able to construct logical arguments using facts and reason. A feminist perspective provides an alternative point of view on the value of argumentation. The purpose of this study was to question the theories that frame the current CCSS 9-12 English…

Strengthen Your Music Program by Incorporating Aspects of the ELA Common Core State Standards

ERIC Educational Resources Information Center

Smith, Nancy Thompson

2014-01-01

Implementation of the English Language Arts (ELA) Common Core State Standards (CCSS) reduces the traditional separation between the study of different subjects. Increased focus on nonfiction reading and writing means more incorporation of other content, such as music, into language arts classes. CCSS's emphasis on speaking and writing across…

The Development and Scaling of the easyCBM CCSS Middle School Mathematics Measures. Technical Report #1207

ERIC Educational Resources Information Center

Anderson, Daniel; Irvin, P. Shawn; Patarapichayatham, Chalie; Alonzo, Julie; Tindal, Gerald

2012-01-01

In the following technical report, we describe the development and scaling of the easyCBM CCSS middle school mathematics measures, designed for use within a response to intervention framework. All items were developed in collaboration with experienced middle school mathematics teachers and were written to align with the Common Core State…

Comparison of Virginia's 2009 Mathematics Standards of Learning with the Common Core State Standards for Mathematics

ERIC Educational Resources Information Center

Virginia Department of Education, 2011

2011-01-01

This first draft of the "Comparison of Virginia's 2009 Mathematics Standards of Learning (SOL) with the Common Core State Standards (CCSS) for Mathematics" provides a side-by-side overview demonstrating how the 2009 Mathematics SOL are aligned to the CCSS. The comparison was made using Virginia's complete standards program for supporting…

How Shall I Teach Thee? An Uncommon Pedagogy for the Common Core.

ERIC Educational Resources Information Center

Vecellio, Shawn

2013-01-01

In this article the author examines the Common Core State Standards (CCSS) to argue for changes in "standards-based" perspectives and practices that grew out of No Child Left Behind. Drawing on an article by David T. Conley, cochairman of the Validation Committee for the CCSS, the author offers a new model for the professional…

Common Core State Standards: An Example of Data-Less Decision Making

ERIC Educational Resources Information Center

Tienken, Christopher H., Ed.

2011-01-01

The Common Core State Standards (CCSS) initiative continues to move forward. As of October 2010, 37 states and territories made the CCSS the legal law of their land in terms of the mathematics and language arts curricula used in their public schools. Over 170 organizations, education-related and corporations alike, have pledged their support to…

A Psychometric Analysis of Teacher-Made Benchmark Assessments in English Language Arts

ERIC Educational Resources Information Center

Milligan, Andrea

2017-01-01

The implementation of the Common Core State Standards (CCSS) has placed increased accountability for outcomes on both students and teachers. To address the current youth literacy crisis in the United States, the CCSS call for students to read increasingly complex informational and literary texts. Since teachers are held accountable for students'…

Research-Based Writing Practices and the Common Core: Meta-Analysis and Meta-Synthesis

ERIC Educational Resources Information Center

Graham, Steve; Harris, Karen R.; Santangelo, Tanya

2015-01-01

In order to meet writing objectives specified in the Common Core State Standards (CCSS), many teachers need to make significant changes in how writing is taught. While CCSS identified what students need to master, it did not provide guidance on how teachers are to meet these writing benchmarks. The current article presents research-supported…

Trends in State Implementation of the Common Core State Standards: Educator Effectiveness. Issue Brief

ERIC Educational Resources Information Center

National Governors Association, 2018

2018-01-01

In 2010, the National Governors Association Center for Best Practices (NGA Center) and the Council of Chief State School Officers (CCSSO) released the Common Core State Standards (CCSS) for K-12 English language arts/literacy and mathematics. CCSS are a state-led effort to define the knowledge and skills students need to graduate from high school…

College and Career Ready: Preparing Students in Fitness and Health Literacy

ERIC Educational Resources Information Center

Buskist, Connie; Reilly, Erin; Walker, Andria; Bourke, Nicholas

2016-01-01

The Common Core State Standards (CCSS) for English language arts have been adopted by many states across the country in an effort to prepare students for life after high school, whether that be going to college or joining the work force. The anchor standards of the CCSS, known as the College and Career Ready Standards, describe the literacy skills…

Teachers' Perceptions of the Implementation of the Literacy Common Core State Standards for English Language Learners and Students with Disabilities

ERIC Educational Resources Information Center

Murphy, Audrey Figueroa; Haller, Elizabeth

2015-01-01

This qualitative study explored the experiences of U.S. teachers of English language learners (ELLs) and students with disabilities (SWDs) as they sought to align the new Common Core State Standards (CCSS) with previously used standards and instructional approaches during the first year of CCSS implementation. Open-ended interviews were conducted…

Moving beyond Compliance: Promoting Research-Based Professional Discretion in the Implementation of the Common Core State Standards in English Language Arts

ERIC Educational Resources Information Center

Woodard, Rebecca; Kline, Sonia

2015-01-01

State- and local-level mandates are currently being implemented to ensure strict compliance to the new national Common Core State Standards for English Language Arts (CCSS for ELA) and related assessments. These standards provide many potential opportunities to improve literacy education nationally and locally. However, the CCSS for ELA will…

Using Multiple Sources of Information in Establishing Text Complexity. Reading Research Report. #11.03

ERIC Educational Resources Information Center

Hiebert, Elfrieda H.

2011-01-01

A focus of the Common Core State Standards/English Language Arts (CCSS/ELA) is that students become increasingly more capable with complex text over their school careers. This focus has redirected attention to the measurement of text complexity. Although CCSS/ELA suggests multiple criteria for this task, the standards offer a single measure of…

Getting to the Core: How Early Implementers Are Approaching the Common Core in California

ERIC Educational Resources Information Center

Brown, Brentt; Vargo, Merrill

2014-01-01

California has embarked on a major new wave of curriculum reform with the adoption of the Common Core State Standards (CCSS), the new English Language Development (ELD) standards, and the Next Generation Science Standards (NGSS). The adoption of the CCSS builds a legacy of standards-based education reform in California that began with the…

CCSS Literacy and Math Tools: An Interim Report on Implementation and Sustainability during the Pilot Year

ERIC Educational Resources Information Center

Reumann-Moore, Rebecca; Lawrence, Nancy; Sanders, Felicia; Shaw, Kate; Christman, Jolley Bruce

2011-01-01

This document summarizes the findings from the initial round of research on the development and piloting of two types of instructional tools designed to support teachers' integration of the Common Core State Standards (CCSS) in literacy and math. In this interim report, Research for Action (RFA) presents key findings from the first half of the…

Comparison of Virginia's 2010 English Standards of Learning with the Common Core State Standards for English and Literacy

ERIC Educational Resources Information Center

Virginia Department of Education, 2010

2010-01-01

The "Comparison of Virginia's 2010 English Standards of Learning (SOL) with the Common Core State Standards (CCSS) for English Language Arts and Literacy (ELAL)" provides a side-by-side overview demonstrating how the 2010 English SOL are aligned to the CCSS for ELAL. The comparison was made using Virginia's complete standards program for…

Common Core State Standards for Literacy in History/Social Studies, Science, and Technical Subjects for English Language Learners

ERIC Educational Resources Information Center

de Oliveira, Luciana C., Ed.

2016-01-01

This volume in the Common Core State Standards (CCSS) for English Language Learners series was designed to deepen teacher's knowledge and provides instructional approaches and practices for supporting grades 6-12 ELLs as they meet the ambitious expectations of the CCSS for Literacy in History/Social Studies, Science, and Technical Subjects. This…

Solving the Common Core Equation: Teaching Mathematics CCSS to Students with Moderate and Severe Disabilities

ERIC Educational Resources Information Center

Saunders, Alicia F.; Bethune, Keri S.; Spooner, Fred; Browder, Diane

2013-01-01

The Common Core State Standards (CCSS) in mathematics were created to help all students become prepared for the demands of future careers and life in an age of technology. Similarly, students with moderate and severe disability will need these skills to meet these changing expectations. Although mathematics instruction could focus on a few of the…

Overview of the Common Core State Standards Initiatives for ELLs. TESOL Issue Brief

ERIC Educational Resources Information Center

TESOL International Association, 2013

2013-01-01

The purpose of this issue brief is to provide a comprehensive overview of the policies behind the Common Core State Standards (CCSS) and to outline some of the initiatives now in place to address the needs of English language learners (ELLs) in relation to the CCSS. This issue brief contains the appendices: (1) Assessment Consortia Time Lines; and…

Finding a Place for CCSS Literacy Skills in the Middle School Social Studies Curriculum

ERIC Educational Resources Information Center

Evans, Marianne Bristow; Clark, Sarah K.

2015-01-01

With the increased emphasis on college and career readiness resulting from the adoption of the Common Core State Standards (CCSS), the need for students to be able to read and write proficiently has become well established. Social studies teachers are now expected to teach nonfiction reading and writing skills in their content-area courses. Many…

The Relationship between Chemistry Self-Efficacy of South African First Year University Students and Their Academic Performance

ERIC Educational Resources Information Center

Ramnarain, Umesh; Ramaila, Sam

2018-01-01

This study investigated the self-efficacy of first-year Chemistry students at a South African university. The research involved a quantitative survey of 333 students using the College Chemistry Self-Efficacy Scale (CCSS) developed by Uzuntiryaki and Capa Aydin (2009). Descriptive statistics on data for the CCSS scales suggested that students have…

Common Core State Standards for ELA/Literacy and Next Generation Science Standards: Convergences and Discrepancies Using Argument as an Example

ERIC Educational Resources Information Center

Lee, Okhee

2017-01-01

As the Common Core State Standards (CCSS) for English language arts (ELA)/literacy and the Next Generation Science Standards (NGSS) highlight connections across subject areas, convergences and discrepancies come into view. As a prominent example, this article focuses on how the CCSS and the NGSS treat "argument," especially in Grades…

Health behaviors of minority childhood cancer survivors.

PubMed

Stolley, Melinda R; Sharp, Lisa K; Tangney, Christy C; Schiffer, Linda A; Arroyo, Claudia; Kim, Yoonsang; Campbell, Richard T; Schmidt, Mary Lou; Breen, Kathleen; Kinahan, Karen E; Dilley, Kim J; Henderson, Tara O; Korenblit, Allen D; Seligman, Katya

2015-05-15

Available data have suggested that childhood cancer survivors (CCSs) are comparable to the general population with regard to many lifestyle parameters. However, to the authors' knowledge, little is known regarding minority CCSs. This cross-sectional study describes and compares the body mass index and health behaviors of African American, Hispanic, and white survivors with each other and with noncancer controls. Participants included 452 adult CCSs (150 African American, 152 Hispanic, and 150 white individuals) recruited through 4 childhood cancer treating institutions and 375 ethnically matched noncancer controls (125 in each racial/ethnic group) recruited via targeted digit dial. All participants completed a 2-hour in-person interview. Survivors and noncancer controls reported similar health behaviors. Within survivors, smoking and physical activity were found to be similar across racial/ethnic groups. African American and Hispanic survivors reported lower daily alcohol use compared with white individuals, but consumed unhealthy diets and were more likely to be obese. This unique study highlights that many minority CCSs exhibit lifestyle profiles that contribute to an increased risk of chronic diseases and late effects. Recommendations for behavior changes must consider the social and cultural context in which minority survivors may live. © 2015 American Cancer Society.

Experimental and Analytical Performance of a Dual Brayton Power Conversion System

NASA Technical Reports Server (NTRS)

Lavelle, Thomas A.; Hervol, David S.; Briggs, Maxwell; Owen, A. Karl

2009-01-01

The interactions between two closed Brayton cycle (CBC) power conversion units (PCU) which share a common gas inventory and heat source have been studied experimentally using the Dual Brayton Power Conversion System (DBPCS) and analytically using the Closed- Cycle System Simulation (CCSS) computer code. Selected operating modes include steady-state operation at equal and unequal shaft speeds and various start-up scenarios. Equal shaft speed steady-state tests were conducted for heater exit temperatures of 840 to 950 K and speeds of 50 to 90 krpm, providing a system performance map. Unequal shaft speed steady-state testing over the same operating conditions shows that the power produced by each Brayton is sensitive to the operating conditions of the other due to redistribution of gas inventory. Startup scenarios show that starting the engines one at a time can dramatically reduce the required motoring energy. Although the DBPCS is not considered a flight-like system, these insights, as well as the operational experience gained from operating and modeling this system provide valuable information for the future development of Brayton systems.

Common Core Implementation: A Quantitative Study Measuring the Change of Instructional Practices Due to Common Core

ERIC Educational Resources Information Center

Berg, John Sonje

2017-01-01

The philosophy behind the Common Core State Standards (CCSS) and its tenets of critical thought, creativity, and application of knowledge require a shift from a focus on content knowledge to how that knowledge is applied across the curriculum and why it forms the foundation of education. The problem now facing educators is that CCSS has changed…

Investigating the Language Demands in the Common Core State Standards for English Language Learners: A Comparison Study of Standards

ERIC Educational Resources Information Center

Wolf, Mikyung Kim; Wang, Yuan; Huang, Becky H.; Blood, Ian

2014-01-01

This study reports on a critical review of the language demands contained in the Common Core State Standards for English language arts (CCSS-ELA) with the aim of deriving important implications for the instruction of English language learners. The language demands of the CCSS-ELA were compared with those of existing English language arts (ELA) and…

Common Core English and Language Arts K-1 Exemplar Text Set: A Critical Content Analysis of Cultural Representations

ERIC Educational Resources Information Center

McCaffrey, Megan

2014-01-01

With the implementation of Common Core State Standards (CCSS) in over forty states, teachers are putting into practice the CCSS text exemplars of text complexity. Of particular concern for the purpose of this research are the kindergarten and first grade (K-1) read aloud and independent text exemplar lists. While not intended as core reading…

Internal Consistency of the easyCBM© CCSS Reading Measures: Grades 3-8. Technical Report #1407

ERIC Educational Resources Information Center

Guerreiro, Meg; Alonzo, Julie; Tindal, Gerald

2014-01-01

This technical report documents findings from a study of the internal consistency and split-half reliability of the easyCBM© CCSS Reading measures, grades 3-8. Data, drawn from an extant data set gathered in school year 2013-2014, include scores from over 150,000 students' fall and winter benchmark assessments. Findings suggest that the easyCBM©…

Implementing the Common Core State Standards: Year Three Progress Report from the Great City Schools. Results from 2013-14 School Year

ERIC Educational Resources Information Center

Palacios, Moses; Casserly, Michael; Corcoran, Amanda; Hart, Ray; Simon, Candace; Uzzell, Renata

2014-01-01

Three years ago, the "Council of the Great City Schools" embarked on a multi-year initiative to help its member school districts implement the Common Core State Standards (CCSS). Part of this initiative involves annual surveys of progress urban public school districts were making in implementing the CCSS. With the support of the Bill…

Year 3 of Implementing the Common Core State Standards: States Prepare for Common Core Assessments

ERIC Educational Resources Information Center

Rentner, Diane Stark

2013-01-01

With the voluntary Common Core State Standards (CCSS), states have sought to establish clear, high expectations that are consistent across participating states and that signal what K-12 students should learn in mathematics and English language arts (ELA) to be prepared for college and careers. As of July 2013, the CCSS have been adopted by 45…

The Childhood Cancer Survivor Study-Neurocognitive Questionnaire (CCSS-NCQ) Revised: Item Response Analysis and Concurrent Validity

PubMed Central

Kenzik, Kelly M.; Huang, I-Chan; Brinkman, Tara M.; Baughman, Brandon; Ness, Kirsten K.; Shenkman, Elizabeth A.; Hudson, Melissa M.; Robison, Leslie L.; Krull, Kevin R.

2014-01-01

Objective Childhood cancer survivors are at risk for neurocognitive impairment related to cancer diagnosis or treatment. This study refined and further validated the Childhood Cancer Survivor Study Neurocognitive Questionnaire (CCSS-NCQ), a scale developed to screen for impairment in long-term survivors of childhood cancer. Method Items related to task efficiency, memory, organization and emotional regulation domains were examined using item response theory (IRT). Data were collected from 833 adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study who completed self-report and direct neurocognitive testing. The revision process included: 1) content validity mapping of items to domains, 2) constructing a revised CCSS-NCQ, 3) selecting items within specific domains using IRT, and 4) evaluating concordance between the revised CCSS-NCQ and direct neurocognitive assessment. Results Using content and measurement properties, 32 items were retained (8 items in 4 domains). Items captured low to middle levels of neurocognitive concerns. The latent domain scores demonstrated poor convergent/divergent validity with the direct assessments. Adjusted effect sizes (Cohen's d) for agreement between self-reported memory and direct memory assessment were moderate for total recall (ES=0.66), long-term memory (ES=0.63), and short-term memory (ES=0.55). Effect sizes between self-rated task efficiency and direct assessment of attention were moderate for focused attention (ES=0.70) and attention span (ES=0.50), but small for sustained attention (ES=0.36). Cranial radiation therapy and female gender were associated with lower self-reported neurocognitive function. Conclusion The revised CCSS-NCQ demonstrates adequate measurement properties for assessing day-to-day neurocognitive concerns in childhood cancer survivors, and adds useful information to direct assessment. PMID:24933482

Endocrinological analysis of 122 Japanese childhood cancer survivors in a single hospital.

PubMed

Miyoshi, Yoko; Ohta, Hideaki; Hashii, Yoshiko; Tokimasa, Sadao; Namba, Noriyuki; Mushiake, Sotaro; Hara, Junichi; Ozono, Keiichi

2008-12-01

With recent improvements in the diagnosis and treatment of cancer, the number of childhood cancer survivors (CCSs) has been increasing in Japan. The importance of quality of life during the lifetime of CCSs has now been recognized, and the late effects of cancer treatments are essential and important issues. In this study we analyzed the endocrinological abnormalities of CCSs by retrospectively evaluating 122 outpatients (62 males and 60 females) who had been referred from pediatric oncologists to our follow-up clinic among 151 CCSs attending our hospital more than two years after their cancer treatment. Follow-up duration varied from 2 to 30 (median 8.0) years. Their average age was 17.3 (range 4-36, median 17.0) years, and 38 patients (31.1%) reached adulthood. Endocrinological abnormalities were found in 82 (67%) of 122 survivors. Gonadal dysfunction was observed in 60 patients (49%). Thirty-nine patients (32%) were short or grew at a slower rate. Twenty-six patients (21%) showed thyroid dysfunction. Other abnormalities were as follows: obesity in 20 patients (16%), leanness in 10 (8%), central diabetes insipidus in 11 (9%) and adrenocortical dysfunction in 9 (7%). Low bone mineral density was observed in 41 (42%) of 98 patients evaluated. These endocrinological abnormalities were caused by the combined effects of cancer itself and various treatments (chemotherapy, radiation therapy, surgery, and hematopoietic stem cell transplantation). Lifetime medical surveillance and continuous follow-up are necessary for CCSs, because treatment-related complications may occur during childhood and many years after the therapy as well. Endocrinologists should participate in long-term follow-up of these survivors in collaboration with pediatric oncologists.

Is screening for abnormal ECG patterns justified in long-term follow-up of childhood cancer survivors treated with anthracyclines?

PubMed

Pourier, Milanthy S; Mavinkurve-Groothuis, Annelies M C; Loonen, Jacqueline; Bökkerink, Jos P M; Roeleveld, Nel; Beer, Gil; Bellersen, Louise; Kapusta, Livia

2017-03-01

ECG and echocardiography are noninvasive screening tools to detect subclinical cardiotoxicity in childhood cancer survivors (CCSs). Our aims were as follows: (1) assess the prevalence of abnormal ECG patterns, (2) determine the agreement between abnormal ECG patterns and echocardiographic abnormalities; and (3) determine whether ECG screening for subclinical cardiotoxicity in CCSs is justified. We retrospectively studied ECG and echocardiography in asymptomatic CCSs more than 5 years after anthracycline treatment. Exclusion criteria were abnormal ECG and/or echocardiogram at the start of therapy, incomplete follow-up data, clinical heart failure, cardiac medication, and congenital heart disease. ECG abnormalities were classified using the Minnesota Code. Level of agreement between ECG and echocardiography was calculated with Cohen kappa. We included 340 survivors with a mean follow-up of 14.5 years (range 5-32). ECG was abnormal in 73 survivors (21.5%), with ventricular conduction disorders, sinus bradycardia, and high-amplitude R waves being most common. Prolonged QTc (>0.45 msec) was found in two survivors, both with a cumulative anthracycline dose of 300 mg/m 2 or higher. Echocardiography showed abnormalities in 44 survivors (12.9%), mostly mild valvular abnormalities. The level of agreement between ECG and echocardiography was low (kappa 0.09). Male survivors more often had an abnormal ECG (corrected odds ratio: 3.00, 95% confidence interval: 1.68-5.37). Abnormal ECG patterns were present in 21% of asymptomatic long-term CCSs. Lack of agreement between abnormal ECG patterns and echocardiographic abnormalities may suggest that ECG is valuable in long-term follow-up of CCSs. However, it is not clear whether these abnormal ECG patterns will be clinically relevant. © 2016 Wiley Periodicals, Inc.

Determination of Collision Cross Sections Using a Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer

NASA Astrophysics Data System (ADS)

Dziekonski, Eric T.; Johnson, Joshua T.; Lee, Kenneth W.; McLuckey, Scott A.

2018-02-01

Collision cross sections (CCSs) were determined from the frequency-domain linewidths in a Fourier transform electrostatic linear ion trap. With use of an ultrahigh-vacuum precision leak valve and nitrogen gas, transients were recorded as the background pressure in the mass analyzer chamber was varied between 4× 10-8 and 7 × 10-7 Torr. The energetic hard-sphere ion-neutral collision model, described by Xu and coworkers, was used to relate the recorded image charge to the CCS of the molecule. In lieu of our monoisotopically isolating the mass of interest, the known relative isotopic abundances were programmed into the Lorentzian fitting algorithm such that the linewidth was extracted from a sum of Lorentzians. Although this works only if the isotopic distribution is known a priori, it prevents ion loss, preserves the high signal-to-noise ratio, and minimizes the experimental error on our homebuilt instrument. Six tetraalkylammonium cations were used to correlate the CCS measured in the electrostatic linear ion trap with that measured by drift-tube ion mobility spectrometry, for which there was an excellent correlation ( R 2 ≈ 0.9999). Although the absolute CCSs derived with our method differ from those reported, the extracted linear correlation can be used to correct the raw CCS. With use of [angiotensin II]2+ and reserpine, the corrected CCSs (334.9 ± 2.1 and 250.1 ± 0.5, respectively) were in good agreement with the reported ion mobility spectrometry CCSs (335 and 254.3, respectively). With sufficient signal-to-noise ratio, the CCSs determined are reproducible to within a fraction of a percent, comparable to the uncertainties reported on dedicated ion mobility instruments.

How Californians View Education Standards, Testing and Accountability: Results from the Third PACE/USC Rossier Poll

ERIC Educational Resources Information Center

Plank, David N.; Brewer, Dominic J.; Polikoff, Morgan; Hall, Michelle

2013-01-01

California is in the midst of sweeping education changes. The state is rolling out the Common Core State Standards (CCSS) and a new system of assessments. Voters approved a temporary statewide tax increase that will provide additional funding to schools after years of spending cuts. The Legislature adopted a new system for funding schools (the…

Mathematics Formative Assessment System--Common Core State Standards: A Randomized Field Trial in Kindergarten and First Grade

ERIC Educational Resources Information Center

Lang, Laura B.; Schoen, Robert R.; LaVenia, Mark; Oberlin, Maureen

2014-01-01

The Florida Center for Research in Science, Technology, Engineering and Mathematics (FCR-STEM) was awarded a grant by the Florida Department of Education to develop a Mathematics Formative Assessment System (MFAS) aligned with the Common Core State Standards (CCSS). Intended for both teachers and students, formative assessment is a process that…

The Influences of Middle School Mathematics Teachers' Practical Rationality on Instructional Decision Making Regarding the Common Core State Standards for Mathematical Practices

ERIC Educational Resources Information Center

Sobolewski-McMahon, Lauren M.

2017-01-01

The purpose of this study was to examine the influences of various facets of middle school mathematics teachers' practical rationality on their instructional decision making as they plan to enact the Common Core State Standards for Mathematical Practice, CCSS-MP1 (perseverance in problem solving) and CCSS-MP3 (communicating and critiquing). The…

Upping the Ante of Text Complexity in the Common Core State Standards: Examining Its Potential Impact on Young Readers

ERIC Educational Resources Information Center

Hiebert, Elfrieda H.; Mesmer, Heidi Anne E.

2013-01-01

The Common Core Standards for the English Language Arts (CCSS) provide explicit guidelines matching grade-level bands (e.g., 2-3, 4-5) with targeted text complexity levels. The CCSS staircase accelerates text expectations for students across Grades 2-12 in order to close a gap in the complexity of texts typically used in high school and those of…

Trends in State Implementation of the Common Core State Standards: Making the Shift to Better Tests. NGA Paper

ERIC Educational Resources Information Center

Nielson, Kate

2014-01-01

The Common Core State Standards (CCSS) for K-12 English language arts/literacy and mathematics, released in 2010, have been adopted by 49 states and territories; the District of Columbia; and the U.S. Department of Defense schools, which serve the children of U.S. service members around the world. The widespread adoption of the CCSS is a major…

High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance.

PubMed

Hudson, Melissa M; Mulrooney, Daniel A; Bowers, Daniel C; Sklar, Charles A; Green, Daniel M; Donaldson, Sarah S; Oeffinger, Kevin C; Neglia, Joseph P; Meadows, Anna T; Robison, Leslie L

2009-05-10

Childhood cancer survivors often experience complications related to cancer and its treatment that may adversely affect quality of life and increase the risk of premature death. The purpose of this manuscript is to review how data derived from Childhood Cancer Survivor Study (CCSS) investigations have facilitated identification of childhood cancer survivor populations at high risk for specific organ toxicity and secondary carcinogenesis and how this has informed clinical screening practices. Articles previously published that used the resource of the CCSS to identify risk factors for specific organ toxicity and subsequent cancers were reviewed and results summarized. CCSS investigations have characterized specific groups to be at highest risk of morbidity related to endocrine and reproductive dysfunction, pulmonary toxicity, cerebrovascular injury, neurologic and neurosensory sequelae, and subsequent neoplasms. Factors influencing risk for specific outcomes related to the individual survivor (eg, sex, race/ethnicity, age at diagnosis, attained age), sociodemographic status (eg, education, household income, health insurance) and cancer history (eg, diagnosis, treatment, time from diagnosis) have been consistently identified. These CCSS investigations that clarify risk for treatment complications related to specific treatment modalities, cumulative dose exposures, and sociodemographic factors identify profiles of survivors at high risk for cancer-related morbidity who deserve heightened surveillance to optimize outcomes after treatment for childhood cancer.

MILSCAP: Military Standard Contract Administration Procedures

DTIC Science & Technology

1993-02-01

Materiel Command, use the Commodity Command Standard System (CCSS) and issue Procurement Automated Document and Distribution System ( PADDS ) generated ...i Table of Contents Acronyms and Abbreviations xi References xv Definitions and Terms xvii CHAPTER 1 - ADMINISTRATIVE AND GENERAL A. Authority 1-1 B...2 - SYSTM CONCEPT A. General 2-1 B. Provisions 2-1 C. Overall System Description 2-2 D. Relationship of Certain FAR and DFARS Provisions to MILSCAP 2

Complementing the characterization of in vivo generated N-glucuronic acid conjugates of stanozolol by collision cross section computation and analysis.

PubMed

Thevis, Mario; Dib, Josef; Thomas, Andreas; Höppner, Sebastian; Lagojda, Andreas; Kuehne, Dirk; Sander, Mark; Opfermann, Georg; Schänzer, Wilhelm

2015-01-01

Detailed structural information on metabolites serving as target analytes in clinical, forensic, and sports drug testing programmes is of paramount importance to ensure unequivocal test results. In the present study, the utility of collision cross section (CCS) analysis by travelling wave ion mobility measurements to support drug metabolite characterization efforts was tested concerning recently identified glucuronic acid conjugates of the anabolic-androgenic steroid stanozolol. Employing travelling-wave ion mobility spectrometry/quadrupole-time-of-flight mass spectrometry, drift times of five synthetically derived and fully characterized steroid glucuronides were measured and subsequently correlated to respective CCSs as obtained in silico to form an analyte-tailored calibration curve. The CCSs were calculated by equilibrium structure minimization (density functional theory) using the programmes ORCA with the data set B3LYP/6-31G and MOBCAL utilizing the trajectory method (TM) with nitrogen as drift gas. Under identical experimental conditions, synthesized and/or urinary stanozolol-N and O-glucuronides were analyzed to provide complementary information on the location of glucuronidation. Finally, the obtained data were compared to CCS results generated by the system's internal algorithm based on a calibration employing a polyalanine analyte mixture. The CCSs ΩN2 calculated for the five steroid glucuronide calibrants were found between 180 and 208 Å(2) , thus largely covering the observed and computed CCSs for stanozolol-N1'-, stanozolol-N2'-, and stanozolol-O-glucuronide found at values between 195.1 and 212.4 Å(2) . The obtained data corroborated the earlier suggested N- and O-glucuronidation of stanozolol, and demonstrate the exploit of ion mobility and CCS computation in structure characterization of phase-II metabolic products; however, despite reproducibly measurable differences in ion mobility of stanozolol-N1'-, N2'-, and O-glucuronides, the discriminatory power of the chosen CCS computation algorithm was found to be not appropriate to allow for accurate assignments of the two N-conjugated structures. Using polyalanine-based calibrations, significantly different absolute values were obtained for all CCSs, but due to a constant offset of approximately 45 Å(2) an excellent correlation (R(2)  = 0.9997) between both approaches was observed. This suggests a substantially accelerated protocol when patterns of computed and polyalanine-based experimental data can be used for structure elucidations instead of creating individual analyte-specific calibration curves. Copyright © 2015 John Wiley & Sons, Ltd.

First Destination Transportation Study

DTIC Science & Technology

1978-03-03

avoidance potentials on a daily procurement basis. A "total" sys- tematic cost evaluation program, including specific de - cision rules needed on an...implementation priority :x needed. The rec- ommended priority is as follows: [ (1) Develop improved system management concepts that will "form the framework ...priority as it provides the overall framework for better system management. Cost evaluation and CCSS Enhancement Programs deserve next consideration, as

Experimental measurements and evaluation of the expanded water repellent perlite used for the cargo containment system of LNG carrier

NASA Astrophysics Data System (ADS)

Li, Manfeng; Ju, Yonglin

2017-10-01

To minimize the water absorption and to improve the thermal insulated properties of the insulation materials used for the cargo containment systems (CCSs) of LNG carrier, a kind of expanded water-repellent perlite has been developed by coating hydrophobic membrane onto the outer surface of the expanded perlite to change its physical and chemical characteristics. Considering the CCSs operated in a wide temperature range from environmental temperature to cryogenic temperature, the thermal analysis has been conducted to quantitatively determine the thermal insulted properties of the insulation materials. Furthermore, a double-sided guarded hot plate apparatus (GHP) is specifically designed and fabricated for the measurement of the thermal conductivities of the insulation specimens operated down to liquid nitrogen temperature. The breakage ratio associated with the water absorption and the thermal conductivity of the expanded water-repellent perlite is firstly proposed, and then a series of experiments are carried out to determine the thermal conductivity of the expanded water-repellent perlite ranging from room temperature to cryogenic temperature based on the different breakage ratios.

RIT Stability through the Transition to Common Core-Aligned MAP® Tests. How Using MAP to Measure Student Learning Growth is Reliable Now and in 2014

ERIC Educational Resources Information Center

Northwest Evaluation Association, 2013

2013-01-01

While many educators expect the Common Core State Standards (CCSS) to be more rigorous than previous state standards, some wonder if the transition to CCSS and to a Common Core aligned MAP test will have an impact on their students' RIT scores or the NWEA norms. MAP assessments use a proprietary scale known as the RIT (Rasch unit) scale to measure…

Colonic aberrant crypts may originate from impaired fissioning: relevance to increased risk of neoplasia.

PubMed

Kristt, D; Bryan, K; Gal, R

1999-12-01

Colonic aberrant crypt foci (ACF) can be identified on the unembedded mucosal surface as clusters of abnormal crypts with enlarged, surface opening. Because dysplasia is frequent, and may be a precursor of carcinoma, epithelial changes have been well studied. However, the basis for the distinctive changes in crypt architecture remain unclear. We hypothesized that some of the architectural alterations of aberrant crypts may reflect impaired fissioning during normal crypt duplication cycles. Fissioning begins at the crypt base. Using morphometric and immunocytochemical approaches, we examined 55 human ACF, both dysplastic and nondysplastic, for their architectural features. Non-ACF mucosa was compared. Microscopically, all lesions contained crypts that were attached, paired, dilated, and angulated. In 3 dimensions, these features related to multiple, individual complexes of connected crypts, referred to as connected crypt structures (CCSs). CCSs terminated in enlarged surface openings (2 to 5 x normal) which are morphometrically equivalent to the macroscopic aberrant crypts (P > .1). These openings trap marker dye. Support for an origin of CCSs in impaired basal fissioning is 3-fold. Crypt profiles in ACF are twice as frequent in basal mucosa as superficially (P < .001); in normal mucosa, the ratio is 1. In a CCS with vertically connected, co-planar crypts, the upper parent crypt diameter was the sum of diameters of inferiorly attached daughter crypts (P > .1). Proliferating cell marker, Ki-67, is not expressed at attachment points. In non-ACF mucosa, isolated CCSs consistently occur at foci of mechanical crypt distortion such as mucosal folds. We conclude that a CCS is a fundamental component of ACF of all histotypes. Impairment of normal crypt fissioning is probably a major factor in the histogenesis of CCSs, which often occurs in settings of mechanical distortion of the mucosa. The pathological significance of this process may be in the formation of enlarged crypt openings. The latter could trap dietary carcinogens as they trap dye, and thereby predispose the CCS to dysplasia.

Deficits in Physical Function Among Young Childhood Cancer Survivors

PubMed Central

Hoffman, Megan C.; Mulrooney, Daniel A.; Steinberger, Julia; Lee, Jill; Baker, K. Scott; Ness, Kirsten K.

2013-01-01

Purpose Childhood cancer survivors (CCSs) are at risk for physical disability. The aim of this investigation was to characterize and compare physical performance among CCSs and a group of siblings age < 18 years and determine if diagnosis, treatment, and physical activity levels were associated with lower performance scores. Methods CCSs ≥ 5 years from diagnosis and a sibling comparison group were recruited and evaluated for strength, mobility, and fitness. Physical performance measures were compared in regression models between survivors and siblings by diagnosis and among survivors by treatment exposures and physical activity levels. Results CCSs (n = 183; mean age ± standard deviation [SD], 13.5 ± 2.5 years; 53% male) scored lower than siblings (n = 147; mean age ± SD, 13.4 ± 2.4 years; 50% male) on lower-extremity strength testing, the timed up-and-go (TUG) test, and the 6-minute walk (6MW) test, despite reporting similar levels and types of habitual physical activity. The lowest scores were prevalent among survivors of CNS tumors and bone and soft tissue sarcomas on strength testing (score ± SD: CNS tumors, 76.5 ± 4.7; sarcoma 67.1 ± 7.2 v siblings, 87.3 ± 2.4 Newton-meters quadricep strength at 90° per second; P = .04 and .01, respectively) and among CNS tumor survivors on the TUG (score ± SD: 5.1 ± 0.1 v siblings, 4.4 ± 0.1 seconds; P < .001) and 6MW tests (score ± SD: 533.3 ± 15.6 v siblings, 594.1 ± 8.3 m; P < .001). Conclusion CCSs may have underlying physiologic deficits that interfere with function that cannot be completely overcome by participation in regular physical activity. These survivors may need referral for specialized exercise interventions in addition to usual counseling to remain physically active. PMID:23796992

The Development and Scaling of the easyCBM CCSS Elementary Mathematics Measures: Grade K. Technical Report #1314

ERIC Educational Resources Information Center

Irvin, P. Shawn; Saven, Jessica L.; Alonzo, Julie; Park, Bitnara Jasmine; Anderson, Daniel; Tindal, Gerald

2012-01-01

The results of formative assessments are regularly used to inform important instructional decisions (e.g., targeted intervention) within a response to intervention (RTI) system of teaching and learning. The validity of such instructional decision-making depends, in part, on the alignment between formative measures and the academic content…

The Development and Scaling of the easyCBM CCSS Elementary Mathematics Measures: Grade 2. Technical Report #1316

ERIC Educational Resources Information Center

Irvin, P. Shawn; Saven, Jessica L.; Alonzo, Julie; Park, Bitnara Jasmine; Anderson, Daniel; Tindal, Gerald

2012-01-01

The results of formative assessments are regularly used to inform important instructional decisions (e.g., targeted intervention) within a response to intervention (RTI) system of teaching and learning. The validity of such instructional decision-making depends, in part, on the alignment between formative measures and the academic content…

On the Road to Assessing Deeper Learning: The Status of Smarter Balanced and PARCC Assessment Consortia. CRESST Report 823

ERIC Educational Resources Information Center

Herman, Joan; Linn, Robert

2013-01-01

Two consortia, the Smarter Balanced Assessment Consortium (Smarter Balanced) and the Partnership for Assessment of Readiness for College and Careers (PARCC), are currently developing comprehensive, technology-based assessment systems to measure students' attainment of the Common Core State Standards (CCSS). The consequences of the consortia…

Army Depot Maintenance: More Effective Use of Organic and Contractor Resources

DTIC Science & Technology

1990-06-04

terkerrny (PA) RRAD Red River (TX) IBAD Lexingtor).Bluegrass (KY) 3MPUAD Pueblo (CO) 2000 ANAD CCAD TEAD TOAD SAAO LEAD FMD LBAD PUAfl j] Aut)’onzed Onboard...until it is received by the contractor. That problem could be eliminated by redesigning the process. Specifically, the FTA document that notifies the...should revise CCSS to allow the FTM document to generate an image to LCA, the FTA to create a due-in to the contractor, and CCSS to determine the depot

Cost analysis of different cervical cancer screening strategies in Mexico.

PubMed

Beal, Christyn M; Salmerón, Jorge; Flores, Yvonne N; Torres, Leticia; Granados-García, Víctor; Dugan, Ellen; Lazcano-Ponce, Eduardo

2014-01-01

To compare the costs and number of undetected cases of four cervical cancer screening strategies (CCSS) in Mexico. We estimated the costs and outcomes of the following CCSS: a) conventional Papanicolaou smear (Pap) alone; b) high-risk human papilloma virus testing (HR-HPV) as primary screening with Pap as reflex triage; c) HR-HPV as primary screening with HPV-16/18 typing, liquid-based cytology (LBC) and immunostaining for p16/Ki67 testing as reflex triage, and d) co-testing with HR-HPV and LBC with HPV-16/18 typing and immunostaining for p16/Ki67 as reflex triage. The outcome of interest was high-grade cervical lesions or cervical cancer. HR-HPV testing, HPV typing, LBC testing and immunostaining is the best alternative because it is the least expensive option with an acceptable number of missed cases. The opportunity costs of a poor quality CCSS is many false negatives. Combining multiple tests may be a more cost-effective way to screen for cervical cancer in Mexico.

Predictors of Posttraumatic Stress Symptoms Among Adolescent and Young Adult Survivors of Childhood Cancer: Importance of Monitoring Survivors' Experiences of Family Functioning.

PubMed

Kamibeppu, Kiyoko; Murayama, Shiho; Ozono, Shuichi; Sakamoto, Naoko; Iwai, Tsuyako; Asami, Keiko; Maeda, Naoko; Inada, Hiroko; Kakee, Naoko; Okamura, Jun; Horibe, Keizo; Ishida, Yasushi

2015-11-01

The purpose of this study was to identify factors associated with posttraumatic stress symptoms (PTSS) among Japanese long-term childhood cancer survivors (CCSs). Subjects comprised 185 adolescent and young adult (AYA) CCSs who completed anonymous self-report questionnaires. Attending physicians also completed an anonymous disease/treatment data sheet. Mean age of survivors was approximately 8 years at diagnosis and 23 years at participation. Multiple regression analysis showed that family functioning, satisfaction with social support, being female, and interactions between family functioning and gender and age at the time of diagnosis were associated with PTSS among survivors. This study revealed family functioning as the most predictive factor of PTSS among AYA CCSs in Japan. Even when the survivor may have unchangeable risk factors, family functioning can potentially moderate the effects on PTSS. Thus, it is crucial for health professionals to carefully monitor and attend to survivors' experiences of family functioning to mitigate PTSS. © The Author(s) 2015.

Neurocognitive Status in Long-Term Survivors of Childhood CNS Malignancies: A Report from the Childhood Cancer Survivor Study

PubMed Central

Ellenberg, Leah; Liu, Qi; Gioia, Gerard; Yasui, Yutaka; Packer, Roger J.; Mertens, Ann; Donaldson, Sarah S.; Stovall, Marilyn; Kadan-Lottick, Nina; Armstrong, Gregory; Robison, Leslie L.; Zeltzer, Lonnie K.

2009-01-01

Background Among survivors of childhood cancer, those with Central Nervous System (CNS) malignancies have been found to be at greatest risk for neuropsychological dysfunction in the first few years following diagnosis and treatment. This study follows survivors to adulthood to assess the long term impact of childhood CNS malignancy and its treatment on neurocognitive functioning. Participants & Methods As part of the Childhood Cancer Survivor Study (CCSS), 802 survivors of childhood CNS malignancy, 5937 survivors of non-CNS malignancy and 382 siblings without cancer completed a 25 item Neurocognitive Questionnaire (CCSS-NCQ) at least 16 years post cancer diagnosis assessing task efficiency, emotional regulation, organizational skills and memory. Neurocognitive functioning in survivors of CNS malignancy was compared to that of non-CNS malignancy survivors and a sibling cohort. Within the group of CNS malignancy survivors, multiple linear regression was used to assess the contribution of demographic, illness and treatment variables to reported neurocognitive functioning and the relationship of reported neurocognitive functioning to educational, employment and income status. Results Survivors of CNS malignancy reported significantly greater neurocognitive impairment on all factors assessed by the CCSS-NCQ than non-CNS cancer survivors or siblings (p<.01), with mean T scores of CNS malignancy survivors substantially more impaired that those of the sibling cohort (p<.001), with a large effect size for Task Efficiency (1.16) and a medium effect size for Memory (.68). Within the CNS malignancy group, medical complications, including hearing deficits, paralysis and cerebrovascular incidents resulted in a greater likelihood of reported deficits on all of the CCSS-NCQ factors, with generally small effect sizes (.22-.50). Total brain irradiation predicted greater impairment on Task Efficiency and Memory (Effect sizes: .65 and .63, respectively), as did partial brain irradiation, with smaller effect sizes (.49 and .43, respectively). Ventriculoperitoneal (VP) shunt placement was associated with small deficits on the same scales (Effect sizes: Task Efficiency .26, Memory .32). Female gender predicted a greater likelihood of impaired scores on 2 scales, with small effect sizes (Task Efficiency .38, Emotional Regulation .45), while diagnosis before age 2 years resulted in less likelihood of reported impairment on the Memory factor with a moderate effect size (.64). CNS malignancy survivors with more impaired CCSS-NCQ scores demonstrated significantly lower educational attainment (p<.01), less household income (p<.001) and less full time employment (p<.001). Conclusions Survivors of childhood CNS malignancy are at significant risk for impairment in neurocognitive functioning in adulthood, particularly if they have received cranial radiation, had a VP shunt placed, suffered a cerebrovascular incident or are left with hearing or motor impairments. Reported neurocognitive impairment adversely affected important adult outcomes, including education, employment, income and marital status. PMID:19899829

Polar conic current sheets as sources and channels of energetic particles in the high-latitude heliosphere

NASA Astrophysics Data System (ADS)

Khabarova, Olga; Malova, Helmi; Kislov, Roman; Zelenyi, Lev; Obridko, Vladimir; Kharshiladze, Alexander; Tokumaru, Munetoshi; Sokół, Justyna; Grzedzielski, Stan; Fujiki, Ken'ichi; Malandraki, Olga

2017-04-01

The existence of a large-scale magnetically separated conic region inside the polar coronal hole has been predicted by the Fisk-Parker hybrid heliospheric magnetic field model in the modification of Burger and co-workers (Burger et al., ApJ, 2008). Recently, long-lived conic (or cylindrical) current sheets (CCSs) have been found from Ulysses observations at high heliolatitudes (Khabarova et al., ApJ, 2017). The characteristic scale of these structures is several times lesser than the typical width of coronal holes, and the CCSs can be observed at 2-3 AU for several months. CCS crossings in 1994 and 2007 are characterized by sharp decreases in the solar wind speed and plasma beta typical for predicted profiles of CCSs. In 2007, a CCS was detected directly over the South Pole and strongly highlighted by the interaction with comet McNaught. The finding is confirmed by restorations of solar coronal magnetic field lines that reveal the occurrence of conic-like magnetic separators over the solar poles both in 1994 and 2007. Interplanetary scintillation data analysis also confirms the existence of long-lived low-speed regions surrounded by the typical polar high-speed solar wind in solar minima. The occurrence of long-lived CCSs in the high-latitude solar wind could shed light on how energetic particles reach high latitudes. Energetic particle enhancements up to tens MeV were observed by Ulysses at edges of CCSs both in 1994 and 2007. In 1994 this effect was clearer, probably due to technical reasons. Accelerated particles could be produced either by magnetic reconnection at the edges of a CCS in the solar corona or in the solar wind. We discuss the role of high-latitude CCSs in propagation of energetic particles in the heliosphere and revisit previous studies of energetic particle enhancements at high heliolatitudes. We also suggest that the existence of a CCS can modify the distribution of the solar wind as a function of heliolatitude and consequently impact ionization rates of heliospheric particles such as neutral interstellar gas atoms, pick-up ions or energetic neutral atoms This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 637324 and the Russian Foundation for Basic Research under grant agreements No 17-02-00300 & No 17-02-01328. O. Khabarova, H. Malova, R. Kislov, L. Zelenyi, V. Obridko, A. Kharshiladze, M. Tokumaru , J. Sokół, S. Grzedzielski, K. Fujiki, 2017, the Astrophysical Journal, under review

California's Transition to the Common Core State Standards: The State's Role in Local Capacity Building

ERIC Educational Resources Information Center

Warren, Paul; Murphy, Patrick

2014-01-01

The Common Core State Standards (CCSS) and the Local Control Funding Formula are introducing major changes to California's K-12 system. Implementation of new curricula and instruction is under way at the district level, but California started its transition relatively late and it has taken a more decentralized approach than most other states.…

Integration of the Common Core State Standards into CTE: Challenges and Strategies of Career and Technical Teachers

ERIC Educational Resources Information Center

Asunda, Paul A.; Finnell, Alicia M.; Berry, Nicholas R.

2015-01-01

In recent years, conversations about the importance of education standards in our school systems have intensified. Common Core State Standards (CCSS) are being implemented across most of the country. The standards require a major shift in instruction and the needed supports really are not there. This study investigated the common barriers,…

Math in Common. Taking Stock of Common Core Math Implementation: Supporting Teachers to Shift Instruction. Insights from the Math in Common 2015 Baseline Survey of Teachers and Administrators. Formative Evaluation Cycle Report for the Math in Common Initiative: Volume 3

ERIC Educational Resources Information Center

Perry, Rebecca R.; Finkelstein, Neal D.; Seago, Nanette; Heredia, Alberto; Sobolew-Shubin, Sandy; Carroll, Cathy

2015-01-01

Math in Common® (MiC) is a five-year initiative that supports a formal network of 10 California school districts as they implement the Common Core State Standards in Mathematics (CCSS-M) across grades K-8. In spring 2015, WestEd administered surveys to understand the perspectives on Common Core State Standards-Mathematics (CCSS-M) implementation…

The effect of tensile stress on the conformational free energy landscape of disulfide bonds.

PubMed

Anjukandi, Padmesh; Dopieralski, Przemyslaw; Ribas-Arino, Jordi; Marx, Dominik

2014-01-01

Disulfide bridges are no longer considered to merely stabilize protein structure, but are increasingly recognized to play a functional role in many regulatory biomolecular processes. Recent studies have uncovered that the redox activity of native disulfides depends on their C-C-S-S dihedrals, χ2 and χ'2. Moreover, the interplay of chemical reactivity and mechanical stress of disulfide switches has been recently elucidated using force-clamp spectroscopy and computer simulation. The χ2 and χ'2 angles have been found to change from conformations that are open to nucleophilic attack to sterically hindered, so-called closed states upon exerting tensile stress. In view of the growing evidence of the importance of C-C-S-S dihedrals in tuning the reactivity of disulfides, here we present a systematic study of the conformational diversity of disulfides as a function of tensile stress. With the help of force-clamp metadynamics simulations, we show that tensile stress brings about a large stabilization of the closed conformers, thereby giving rise to drastic changes in the conformational free energy landscape of disulfides. Statistical analysis shows that native TDi, DO and interchain Ig protein disulfides prefer open conformations, whereas the intrachain disulfide bridges in Ig proteins favor closed conformations. Correlating mechanical stress with the distance between the two a-carbons of the disulfide moiety reveals that the strain of intrachain Ig protein disulfides corresponds to a mechanical activation of about 100 pN. Such mechanical activation leads to a severalfold increase of the rate of the elementary redox S(N)2 reaction step. All these findings constitute a step forward towards achieving a full understanding of functional disulfides.

The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: a report from the Childhood Cancer Survivor Study.

PubMed

Green, Daniel M; Nolan, Vikki G; Goodman, Pamela J; Whitton, John A; Srivastava, DeoKumar; Leisenring, Wendy M; Neglia, Joseph P; Sklar, Charles A; Kaste, Sue C; Hudson, Melissa M; Diller, Lisa R; Stovall, Marilyn; Donaldson, Sarah S; Robison, Leslie L

2014-01-01

Estimation of the risk of adverse long-term outcomes such as second malignant neoplasms and infertility often requires reproducible quantification of exposures. The method for quantification should be easily utilized and valid across different study populations. The widely used Alkylating Agent Dose (AAD) score is derived from the drug dose distribution of the study population and thus cannot be used for comparisons across populations as each will have a unique distribution of drug doses. We compared the performance of the Cyclophosphamide Equivalent Dose (CED), a unit for quantifying alkylating agent exposure independent of study population, to the AAD. Comparisons included associations from three Childhood Cancer Survivor Study (CCSS) outcome analyses, receiver operator characteristic (ROC) curves and goodness of fit based on the Akaike's Information Criterion (AIC). The CED and AAD performed essentially identically in analyses of risk for pregnancy among the partners of male CCSS participants, risk for adverse dental outcomes among all CCSS participants and risk for premature menopause among female CCSS participants, based on similar associations, lack of statistically significant differences between the areas under the ROC curves and similar model fit values for the AIC between models including the two measures of exposure. The CED is easily calculated, facilitating its use for patient counseling. It is independent of the drug dose distribution of a particular patient population, a characteristic that will allow direct comparisons of outcomes among epidemiological cohorts. We recommend the use of the CED in future research assessing cumulative alkylating agent exposure. © 2013 Wiley Periodicals, Inc.

Using Data-Informed Instruction to Drive Education: Keeping Catholic Education a Viable and Educationally Sound Option in Challenging Times

ERIC Educational Resources Information Center

Niemeyer, Kristen; Casey, Laura B.; Williamson, Robert; Casey, Cort; Elswick, Susan E.; Black, Tom; Winsor, Denise

2016-01-01

Teachers in Catholic schools are not immune from pressures to improve students' scores on high stakes tests, and standards-based education is not new to Catholic schools. Nationally, many public school systems have moved to implement Common Core State Standards (CCSS) or other similar standards. Assessment, in turn, has been tied to these…

Core to College Evaluation: Exploring the Use of Multiple Measures for Placement into College-Level Courses. Seeking Alternatives or Improvements to the Use of a Single Standardized Test

ERIC Educational Resources Information Center

Bracco, Kathy Reeves; Dadgar, Mina; Austin, Kim; Klarin, Becca; Broek, Marie; Finkelstein, Neal; Mundry, Susan; Bugler, Dan

2014-01-01

"Core to College: Preparing Students for College Readiness and Success" is a three-year initiative. The initiative's mission is to "facilitate greater coordination between K-12 and postsecondary education systems around implementation of the Common Core State Standards (CCSS) and aligned assessments." Its aim is to foster…

Preparing Prospective Elementary Teachers To Foster Conceptually Based Mathematical Understandings: A Study Investigating Change in Prospective Teachers' Conceptions Related to Mathematics Teaching and Learning.

ERIC Educational Resources Information Center

Benken, Babette M.; Brown, Nancy

More than two decades of research and experience supports the idea that computer and calculator technologies can have an important role to play in supporting and effecting student learning (Heid, 1988; Kaput, 1992; Kutzler, 1996; Papert, 1980; Waits and Demana, 1999). The development of Classroom Communication Systems (CCSs) is providing new…

Curriculum Modules in Support of Tabletop Cybersecurity Games

DTIC Science & Technology

2013-09-01

this standard. Another standard that was useful for us to map to was one asking students to use technology to produce and publish writing and to...CCSS.ELA­Literacy.CCRA.W.6 Use  technology , including the Internet, to produce and publish writing  and to interact and collaborate with others. CCSS.ELA­Literacy.CCRA.W.7...evidence that traces this shortage in the United States back to high school education, where computer science is the only one of the Science, Technology

In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment

PubMed Central

van Dam, Peter A.; van Dam, Pieter-Jan H. H.; Rolfo, Christian; Giallombardo, Marco; van Berckelaer, Christophe; Trinh, Xuan Bich; Altintas, Sevilay; Huizing, Manon; Papadimitriou, Kostas; Tjalma, Wiebren A. A.; van Laere, Steven

2016-01-01

An in silico pathway analysis was performed in order to improve current knowledge on the molecular drivers of cervical cancer and detect potential targets for treatment. Three publicly available Affymetrix gene expression data-sets (GSE5787, GSE7803, GSE9750) were retrieved, vouching for a total of 9 cervical cancer cell lines (CCCLs), 39 normal cervical samples, 7 CIN3 samples and 111 cervical cancer samples (CCSs). Predication analysis of microarrays was performed in the Affymetrix sets to identify cervical cancer biomarkers. To select cancer cell-specific genes the CCSs were compared to the CCCLs. Validated genes were submitted to a gene set enrichment analysis (GSEA) and Expression2Kinases (E2K). In the CCSs a total of 1,547 probe sets were identified that were overexpressed (FDR < 0.1). Comparing to CCCLs 560 probe sets (481 unique genes) had a cancer cell-specific expression profile, and 315 of these genes (65%) were validated. GSEA identified 5 cancer hallmarks enriched in CCSs (P < 0.01 and FDR < 0.25) showing that deregulation of the cell cycle is a major component of cervical cancer biology. E2K identified a protein-protein interaction (PPI) network of 162 nodes (including 20 drugable kinases) and 1626 edges. This PPI-network consists of 5 signaling modules associated with MYC signaling (Module 1), cell cycle deregulation (Module 2), TGFβ-signaling (Module 3), MAPK signaling (Module 4) and chromatin modeling (Module 5). Potential targets for treatment which could be identified were CDK1, CDK2, ABL1, ATM, AKT1, MAPK1, MAPK3 among others. The present study identified important driver pathways in cervical carcinogenesis which should be assessed for their potential therapeutic drugability. PMID:26701206

Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study.

PubMed

Green, Daniel M; Kawashima, Toana; Stovall, Marilyn; Leisenring, Wendy; Sklar, Charles A; Mertens, Ann C; Donaldson, Sarah S; Byrne, Julianne; Robison, Leslie L

2009-06-01

This study was undertaken to determine the effect, if any, of treatment for cancer diagnosed during childhood or adolescence on fertility. We reviewed the fertility of female participants in the Childhood Cancer Survivor Study (CCSS), which consisted of 5-year survivors, and a cohort of randomly selected siblings who responded to a questionnaire. Medical records of all members of the cohort were abstracted to obtain chemotherapeutic agents administered; the cumulative dose of drug administered for several drugs of interest; and the doses, volumes, and dates of administration of all radiation therapy. There were 5,149 female CCSS participants, and there were 1,441 female siblings of CCSS participants who were age 15 to 44 years. The relative risk (RR) for survivors of ever being pregnant was 0.81 (95% CI, 0.73 to 0.90; P < .001) compared with female siblings. In multivariate models among survivors only, those who received a hypothalamic/pituitary radiation dose > or = 30 Gy (RR, 0.61; 95% CI, 0.44 to 0.83) or an ovarian/uterine radiation dose greater than 5 Gy were less likely to have ever been pregnant (RR, 0.56 for 5 to 10 Gy; 95% CI, 0.37 to 0.85; RR, 0.18 for > 10 Gy; 95% CI, 0.13 to 0.26). Those with a summed alkylating agent dose (AAD) score of three or four or who were treated with lomustine or cyclophosphamide were less likely to have ever been pregnant. This large study demonstrated that fertility is decreased among female CCSS participants. The risk factors identified may be utilized for pretreatment counseling of patients and their parents.

Prediction of Ischemic Heart Disease and Stroke in Survivors of Childhood Cancer.

PubMed

Chow, Eric J; Chen, Yan; Hudson, Melissa M; Feijen, Elizabeth A M; Kremer, Leontien C; Border, William L; Green, Daniel M; Meacham, Lillian R; Mulrooney, Daniel A; Ness, Kirsten K; Oeffinger, Kevin C; Ronckers, Cécile M; Sklar, Charles A; Stovall, Marilyn; van der Pal, Helena J; van Dijk, Irma W E M; van Leeuwen, Flora E; Weathers, Rita E; Robison, Leslie L; Armstrong, Gregory T; Yasui, Yutaka

2018-01-01

Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors of childhood cancer. Patients and Methods Participants in the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for the development of ischemic heart disease and stroke. Siblings (n = 4,023) established the baseline population risk. Piecewise exponential models with backward selection estimated the relationships between potential predictors and each outcome. The St Jude Lifetime Cohort Study (n = 1,842) and the Emma Children's Hospital cohort (n = 1,362) were used to validate the CCSS models. Results Ischemic heart disease and stroke occurred in 265 and 295 CCSS participants, respectively. Risk scores based on a standard prediction model that included sex, chemotherapy, and radiotherapy (cranial, neck, and chest) exposures achieved an area under the curve and concordance statistic of 0.70 and 0.70 for ischemic heart disease and 0.63 and 0.66 for stroke, respectively. Validation cohort area under the curve and concordance statistics ranged from 0.66 to 0.67 for ischemic heart disease and 0.68 to 0.72 for stroke. Risk scores were collapsed to form statistically distinct low-, moderate-, and high-risk groups. The cumulative incidences at age 50 years among CCSS low-risk groups were < 5%, compared with approximately 20% for high-risk groups ( P < .001); cumulative incidence was only 1% for siblings ( P < .001 v low-risk survivors). Conclusion Information available to clinicians soon after completion of childhood cancer therapy can predict individual risk for subsequent ischemic heart disease and stroke with reasonable accuracy and discrimination through age 50 years. These models provide a framework on which to base future screening strategies and interventions.

Ion mobility spectrometry-mass spectrometry examination of the structures, stabilities, and extents of hydration of dimethylamine-sulfuric acid clusters.

PubMed

Thomas, Jikku M; He, Siqin; Larriba-Andaluz, Carlos; DePalma, Joseph W; Johnston, Murray V; Hogan, Christopher J

2016-08-17

We applied an atmospheric pressure differential mobility analyzer (DMA) coupled to a time-of-flight mass spectrometer to examine the stability, mass-mobility relationship, and extent of hydration of dimethylamine-sulfuric acid cluster ions, which are of relevance to nucleation in ambient air. Cluster ions were generated by electrospray ionization and were of the form: [H((CH3)2NH)x(H2SO4)y](+) and [(HSO4)((CH3)2NH)x(H2SO4)y](-), where 4 ≤ x ≤ 8, and 5 ≤ y ≤ 12. Under dry conditions, we find that positively charged cluster ions dissociated via loss of both multiple dimethylamine and sulfuric acid molecules after mobility analysis but prior to mass analysis, and few parent ions were detected in the mass spectrometer. Dissociation also occurred for negative ions, but to a lesser extent than for positive ions for the same mass spectrometer inlet conditions. Under humidified conditions (relative humidities up to 30% in the DMA), positively charged cluster ion dissociation in the mass spectrometer inlet was mitigated and occurred primarily by H2SO4 loss from ions containing excess acid molecules. DMA measurements were used to infer collision cross sections (CCSs) for all identifiable cluster ions. Stokes-Millikan equation and diffuse/inelastic gas molecule scattering predicted CCSs overestimate measured CCSs by more than 15%, while elastic-specular collision model predictions are in good agreement with measurements. Finally, cluster ion hydration was examined by monitoring changes in CCSs with increasing relative humidity. All examined cluster ions showed a modest amount of water molecule adsorption, with percentage increases in CCS smaller than 10%. The extent of hydration correlates directly with cluster ion acidity for positive ions.

Biotechnology Conference: Diagnostics 󈨛 Held in Cambridge, England on 10 and 11 December 1987.

DTIC Science & Technology

1988-05-25

settings. 1 -hour culture confirmation test for herpes (ColorGene DNA hybridization test for HSV confirmation). This test NEW AMPEROMETRIC BIOSENSORS...I Thin Layer Technology: Monolayers to Multi Thin Films ................. 1 Single-Step Immunoassay Systems...if this thin-layer pr•ccss~is probe technolh,,y. and biosensors. The aim of the con- demonstrated in Figure 1 . which shows the disposition of ference

Cultural Connectedness and Its Relation to Mental Wellness for First Nations Youth.

PubMed

Snowshoe, Angela; Crooks, Claire V; Tremblay, Paul F; Hinson, Riley E

2017-04-01

We explored the interrelationships among components of cultural connectedness (i.e., identity, traditions, and spirituality) and First Nations youth mental health using a brief version of the original Cultural Connectedness Scale. Participants included 290 First Nations youth (M age  = 14.4) who were recruited from both urban and rural school settings in Saskatchewan and Southwestern Ontario. We performed a confirmatory factor analysis of the Cultural Connectedness Scale-Short Version (CCS-S) items to investigate the factor stability of the construct in our sample. We examined the relationships between the CCS-S subscales and self-efficacy, sense of self (present and future), school connectedness, and life satisfaction using hierarchical multiple linear regression analyses to establish the validity of the abbreviated measure. The results revealed that cultural connectedness, as measured by the 10-item CCS-S, had strong associations with the mental health indicators assessed and, in some cases, was associated with First Nations youth mental health above and beyond other social determinants of health. Our results extend findings from previous research on cultural connectedness by elucidating the meaning of its components and demonstrate the importance of culture for positive youth development.

Classroom Observations: Documenting Shifts in Instruction for Districtwide Improvement. Formative Evaluation Cycle Report for the Math in Common Initiative, Volume 2

ERIC Educational Resources Information Center

Perry, Rebecca R.; Seago, Nanette M.; Burr, Elizabeth; Broek, Marie; Finkelstein, Neal D.

2015-01-01

Math in Common® (MiC) is a five-year initiative that supports a formal network of 10 California school districts as they implement the Common Core State Standards in Mathematics (CCSS-M) across grades K-8. This research brief explores how best to select or develop and use classroom observation systems in order to document instructional shifts and…

Astrobiobound! Search for Life in the Solar System: Scientists and Engineers Bringing their Challenges to K-12 Students

NASA Astrophysics Data System (ADS)

Klug Boonstra, S. L.; Swann, J.; Manfredi, L.; Zippay, A.; Boonstra, D.

2014-12-01

The Next Generation Science Standards (NGSS) brought many dynamic opportunities and capabilities to the K-12 science classroom - especially with the inclusion of engineering. Using science as a context to help students engage in the engineering practices and engineering disciplinary core ideas is an essential step to students' understanding of how science drives engineering and how engineering enables science. Real world examples and applications are critical for students to see how these disciplines are integrated. Furthermore, the interface of science and engineering raise the level of science understanding, and facilitate higher order thinking skills through relevant experiences. Astrobiobound! is designed for the NGSS (Next Generation Science Standards) and CCSS (Common Core State Standards). Students also practice and build 21st Century Skills. Astrobiobound! help students see how science and systems engineering are integrated to achieve a focused scientific goal. Students engage in the engineering design process to design a space mission which requires them to balance the return of their science data with engineering limitations such as power, mass and budget. Risk factors also play a role during this simulation and adds to the excitement and authenticity. Astrobiobound! presents the authentic first stages of NASA mission design process. This simulation mirrors the NASA process in which the science goals, type of mission, and instruments to return required data to meet mission goals are proposed within mission budget before any of the construction part of engineering can begin. NASA scientists and engineers were consulted in the development of this activity as an authentic simulation of their mission proposal process.

A cultural research approach to instrument development: the case of breast and cervical cancer screening among Latino and Anglo women

PubMed Central

Betancourt, Hector; Flynn, Patricia M.; Riggs, Matt; Garberoglio, Carlos

2010-01-01

To illustrate the implementation of a bottom-up approach to the study of culture in health disparities, this article describes the development of a cultural cancer screening scale (CCSS) using mixed methodologies. The aim was to identify cultural factors relevant to breast and cervical cancer screening, develop an instrument to assess them and examine its preliminary psychometric properties among Latin American (Latino) and non-Latino White (Anglo) women in Southern California. Seventy-eight Latino and Anglo women participated in semi-structured interviews, which were content coded based on Triandis' methods for the analysis of subjective culture. Based on the emerging cultural elements, items relevant to cancer screening were developed and pilot tested with 161 participants. After the instrument was refined, 314 Latino and Anglo women from various socioeconomic backgrounds completed the CCSS and data were factor analyzed resulting in five cultural factors: cancer screening fatalism, negative beliefs about health professionals, catastrophic disease expectations, symptomatic deterrents and sociocultural deterrents. The instrument demonstrated measurement equivalence, adequate reliability and predictive validity. The research and the CCSS are discussed in terms of implications for the study of culture in relation to health disparities and the development of evidence-based interventions with culturally diverse populations and their health professionals. PMID:20864605

Prognostic value of interleukin-6 and interleukin-6 receptor in organ-confined clear-cell renal cell carcinoma: a 5-year conditional cancer-specific survival analysis.

PubMed

Fu, Qiang; Chang, Yuan; An, Huimin; Fu, Hangcheng; Zhu, Yu; Xu, Le; Zhang, Weijuan; Xu, Jiejie

2015-12-01

Interleukin-6 (IL-6) is the major cytokine that induces transcriptional acute and chronic inflammation responses, and was recently incorporated as a recurrence prognostication signature for localised clear-cell renal cell carcinoma (ccRCC). As the prognostic efficacy of initial risk factors may ebb during long-term practice, we aim to report conditional cancer-specific survival (CCSS) of RCC patients and evaluate the impact of IL-6 as well as its receptor (IL-6R) to offer more relevant prognostic information accounting for elapsing time. We enrolled 180 histologically proven localised ccRCC patients who underwent nephrectomy between 2001 and 2004 with available pathologic information. Five-year CCSS was determined and stratified by future prognostic factors. Constant Cox regression analysis and Harrell's concordance index were used to indicate the predictive accuracy of established models. The 5-year CCSS of organ-confined ccRCC patients with both IL-6- and IL-6R-positive expression was 52% at year 2 after surgery, which was close to locally advanced patients (48%, P=0.564) and was significantly poorer than organ-confined patients with IL-6- or IL-6R-negative expression (89%, P<0.001). Multivariate analyses proved IL-6 and IL-6R as independent predictors after adjusting for demographic factors. Concordance index of pT-IL-6-IL-6R risk stratification was markedly higher compared with the stage, size, grade and necrosis prognostic model (0.724 vs 0.669, P=0.002) or UCLA Integrated Staging System (0.724 vs 0.642, P=0.007) in organ-confined ccRCC population during the first 5 years. Combined IL-6 and IL-6R coexpression emerges as an independent early-stage immunologic prognostic factor for organ-confined ccRCC patients.

Late Mortality Among 5-Year Survivors of Childhood Cancer: A Summary From the Childhood Cancer Survivor Study

PubMed Central

Armstrong, Gregory T.; Liu, Qi; Yasui, Yutaka; Neglia, Joseph P.; Leisenring, Wendy; Robison, Leslie L.; Mertens, Ann C.

2009-01-01

The Childhood Cancer Survivor Study (CCSS) has assembled the largest cohort to date for assessment of late mortality. Vital status and cause of death of all patients eligible for participation in CCSS was determined using the National Death Index and death certificates to characterize the mortality experience of 20,483 survivors, representing 337,334 person-years of observation. A total of 2,821 deaths have occurred as of December 31, 2002. The overall cumulative mortality is 18.1% (95% CI, 17.3 to 18.9) at 30 years from diagnosis. With time, while all-cause mortality rates have been stable, the pattern of late death is changing. Mortality attributable to recurrence or progression of primary disease is decreasing, with increases in rates of mortality attributable to subsequent neoplasms (standardized mortality ratios [SMR], 15.2; 95% CI, 13.9 to 16.6), cardiac death (SMR, 7.0; 95% CI, 5.9 to 8.2), and pulmonary death (SMR, 8.8; 95% CI, 6.8 to 11.2) largely due to treatment-related causes. In addition, the CCSS has identified specific treatment-related risk factors for late mortality. Radiotherapy (relative risk [RR], 2.9; 95% CI, 2.1 to 4.2), alkylating agents (RR, 2.2; 95% CI, 1.6 to 3.0), and epipodophyllotoxins (RR, 2.3; 95% CI, 1.2 to 4.5) increase the risk of death due to subsequent malignancy. Cardiac radiation exposure (RR, 3.3; 95% CI, 2.0 to 5.5) and high dose of anthracycline exposure (RR, 3.1; 95% CI, 1.6 to 5.8) are associated with late cardiac death. By continued longitudinal follow-up of the cohort and expansion of the cohort to include patients diagnosed between 1987 and 1999, the CCSS will remain a primary resource for assessment of late mortality of survivors of childhood cancers. PMID:19332714

A Comparative Evaluation of Normal Tissue Doses for Patients Receiving Radiation Therapy for Hodgkin Lymphoma on the Childhood Cancer Survivor Study and Recent Children's Oncology Group Trials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Rachel; Ng, Angela; Constine, Louis S.

Purpose: Survivors of pediatric Hodgkin lymphoma (HL) are recognized to have an increased risk of delayed adverse health outcomes related to radiation therapy (RT). However, the necessary latency required to observe these late effects means that the estimated risks apply to outdated treatments. We sought to compare the normal tissue dose received by children treated for HL and enrolled in the Childhood Cancer Survivor Study (CCSS) (diagnosed 1970-1986) with that of patients treated in recent Children's Oncology Group (COG) trials (enrolled 2002-2012). Methods and Materials: RT planning data were obtained for 50 HL survivors randomly sampled from the CCSS cohortmore » and applied to computed tomography planning data sets to reconstruct the normal tissue dosimetry. For comparison, the normal tissue dosimetry data were obtained for all 191 patients with full computed tomography–based volumetric RT planning on COG protocols AHOD0031 and AHOD0831. Results: For early-stage patients, the mean female breast dose in the COG patients was on average 83.5% lower than that for CCSS patients, with an absolute reduction of 15.5 Gy. For advanced-stage patients, the mean breast dose was decreased on average by 70% (11.6 Gy average absolute dose reduction). The mean heart dose decreased on average by 22.9 Gy (68.6%) and 17.6 Gy (56.8%) for early- and advanced-stage patients, respectively. All dose comparisons for breast, heart, lung, and thyroid were significantly lower for patients in the COG trials than for the CCSS participants. Reductions in the prescribed dose were a major contributor to these dose reductions. Conclusions: These are the first data quantifying the significant reduction in the normal tissue dose using actual, rather than hypothetical, treatment plans for children with HL. These findings provide useful information when counseling families regarding the risks of contemporary RT.« less

How Closely Related Are Conformations of Protein Ions Sampled by IM-MS to Native Solution Structures?

NASA Astrophysics Data System (ADS)

Chen, Shu-Hua; Russell, David H.

2015-09-01

Here, we critically evaluate the effects of changes in the ion internal energy (Eint) on ion-neutral collision cross sections (CCS) of ions of two structurally diverse proteins, specifically the [M + 6H]6+ ion of ubiquitin (ubq6+), the [M + 5H]5+ ion of the intrinsically disordered protein (IDP) apo-metallothionein-2A (MT), and its partially- and fully-metalated isoform, the [CdiMT]5+ ion. The ion-neutral CCS for ions formed by "native-state" ESI show a strong dependence on Eint. Collisional activation is used to increase Eint prior to the ions entering and within the traveling wave (TW) ion mobility analyzer. Comparisons of experimental CCSs with those generated by molecular dynamics (MD) simulation for solution-phase ions and solvent-free ions as a function of temperature provide new insights about conformational preferences and retention of solution conformations. The Eint-dependent CCSs, which reveal increased conformational diversity of the ion population, are discussed in terms of folding/unfolding of solvent-free ions. For example, ubiquitin ions that have low internal energies retain native-like conformations, whereas ions that are heated by collisional activation possess higher internal energies and yield a broader range of CCS owing to increased conformational diversity due to losses of secondary and tertiary structures. In contrast, the CCS profile for the IDP apoMT is consistent with kinetic trapping of an ion population composed of a wide range of conformers, and as the Eint is increased, these structurally labile conformers unfold to an elongated conformation.

Container Closure Integrity Testing of Prefilled Syringes.

PubMed

Peláez, Sarah S; Mahler, Hanns-Christian; Matter, Anja; Koulov, Atanas; Singh, Satish K; Germershaus, Oliver; Mathaes, Roman

2018-04-05

Prefilled syringes (PFSs) are increasingly preferred over vials as container closure systems (CCSs) for injectable drug products when facilitated or self-administration is required. However, PFSs are more complex compared to CCSs consisting of vial, rubber stopper, and crimp cap. Container closure integrity (CCI) assurance and verification has been a specific challenge for PFSs as they feature several sealing areas. A comprehensive understanding of the CCS is necessary for an appropriate CCI assessment as well as for packaging development and qualification. A comprehensive CCI assessment of 6 different PFSs from 3 different manufacturers (including 1 polymeric PFS) was conducted using helium leak testing. PFS components were manipulated to systematically assess the contribution of the different sealing areas to CCI, namely rigid needle shield (RNS)/needle, RNS/tip cone, and the individual ribs of a syringe plunger. The polymeric PFS required an equilibrium measurement for accurate container closure integrity testing. The different sealing areas and a single plunger rib were shown to provide adequate CCI. Acceptable tip cap movement until the point of CCI failure was estimated. The assessment of acceptable tip cap movement demonstrated the importance of considering the RNS/tip cone seal design to ensure CCI of the PFS upon post assembly possesses and shipment. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Childhood Cancer Survivor Study: An Overview

Cancer.gov

Health problems that develop years later as a result of a cancer treatment are known as late effects. The Childhood Cancer Survivor Study (CCSS) was started in 1994 to better understand these late effects.

Pediatric Cancer Survivorship Research: Experience of the Childhood Cancer Survivor Study

PubMed Central

Leisenring, Wendy M.; Mertens, Ann C.; Armstrong, Gregory T.; Stovall, Marilyn A.; Neglia, Joseph P.; Lanctot, Jennifer Q.; Boice, John D.; Whitton, John A.; Yasui, Yutaka

2009-01-01

The Childhood Cancer Survivor Study (CCSS) is a comprehensive multicenter study designed to quantify and better understand the effects of pediatric cancer and its treatment on later health, including behavioral and sociodemographic outcomes. The CCSS investigators have published more than 100 articles in the scientific literature related to the study. As with any large cohort study, high standards for methodologic approaches are imperative for valid and generalizable results. In this article we describe methodological issues of study design, exposure assessment, outcome validation, and statistical analysis. Methods for handling missing data, intrafamily correlation, and competing risks analysis are addressed; each with particular relevance to pediatric cancer survivorship research. Our goal in this article is to provide a resource and reference for other researchers working in the area of long-term cancer survivorship. PMID:19364957

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Jian; Casey, Cameron P.; Zheng, Xueyun

Motivation: Drift tube ion mobility spectrometry (DTIMS) is increasingly implemented in high throughput omics workflows, and new informatics approaches are necessary for processing the associated data. To automatically extract arrival times for molecules measured by DTIMS coupled with mass spectrometry and compute their associated collisional cross sections (CCS) we created the PNNL Ion Mobility Cross Section Extractor (PIXiE). The primary application presented for this algorithm is the extraction of information necessary to create a reference library containing accu-rate masses, DTIMS arrival times and CCSs for use in high throughput omics analyses. Results: We demonstrate the utility of this approach bymore » automatically extracting arrival times and calculating the associated CCSs for a set of endogenous metabolites and xenobiotics. The PIXiE-generated CCS values were identical to those calculated by hand and within error of those calcu-lated using commercially available instrument vendor software.« less

Shared Care of Childhood Cancer Survivors: A Telemedicine Feasibility Study.

PubMed

Costello, Aimee G; Nugent, Bethany D; Conover, Noelle; Moore, Amanda; Dempsey, Kathleen; Tersak, Jean M

2017-12-01

With an increasing number of childhood cancer survivors (CCSs), determining the best model of survivorship transition care is becoming a growing priority. Shared care between pediatric oncology and adult primary care is often necessary, making survivorship a time of transition, but effective standard models are lacking. We sought to provide a more integrated approach to transition using telemedicine. Recruited primary care provider/CCS dyads were instructed to log-in to a password-protected virtual meeting room using telemedicine equipment at the time or a regularly scheduled office visit. Dyads were joined by a pediatric survivorship clinic team member who conducted the telemedicine portion of the transition visit, which consisted of the review of an individualized treatment summary and care plan. Postquestionnaires were developed to evaluate key points such as fund of knowledge, satisfaction with the visit, and effectiveness of this electronic tool. There were 19 transition visits conducted, 13 of which used the telemedicine equipment as planned. Those that did not use the equipment were primarily unable to due to technical difficulties. Postquestionnaires were overall positive, confirming increased knowledge, comfort and abilities, and patient satisfaction in survivorship care. Negative comments were primarily related to equipment difficulties. A gap still remains in helping CCSs transition from oncology to primary care and this pilot study offered insights into how we might better bridge that gap through the use of telemedicine. Further research is needed to refine the transition process for CCSs, including evaluation and testing models for standard of care.

Long-Term Effects of Radiation Exposure among Adult Survivors of Childhood Cancer: Results from the Childhood Cancer Survivor Study

PubMed Central

Armstrong, Gregory T.; Stovall, Marilyn; Robison, Leslie L.

2010-01-01

In the last four decades, advances in therapies for primary cancers have improved overall survival for childhood cancer. Currently, almost 80% of children will survive beyond 5 years from diagnosis of their primary malignancy. These improved outcomes have resulted in a growing population of childhood cancer survivors. Radiation therapy, while an essential component of primary treatment for many childhood malignancies, has been associated with risk of long-term adverse outcomes. The Childhood Cancer Survivor Study (CCSS), a retrospective cohort of over 14,000 survivors of childhood cancer diagnosed between 1970 and 1986, has been an important resource to quantify associations between radiation therapy and risk of long-term adverse health and quality of life outcomes. Radiation therapy has been associated with increased risk for late mortality, development of second neoplasms, obesity, and pulmonary, cardiac and thyroid dysfunction as well as an increased overall risk for chronic health conditions. Importantly, the CCSS has provided more precise estimates for a number of dose–response relationships, including those for radiation therapy and development of subsequent malignant neoplasms of the central nervous system, thyroid and breast. Ongoing study of childhood cancer survivors is needed to establish long-term risks and to evaluate the impact of newer techniques such as conformal radiation therapy or proton-beam therapy. PMID:21128808

Sampling in the Snow: High School Winter Field Experiences Provide Relevant, Real World Connections Between Scientific Practices and Disciplinary Core Ideas

NASA Astrophysics Data System (ADS)

Hanson, E. W.; Burakowski, E. A.

2014-12-01

For much of the northern United States, the months surrounding the winter solstice are times of increased darkness, low temperatures, and frozen landscapes. It's a time when many high school science educators, who otherwise would venture outside with their classes, hunker down and are wary of the outdoors. However, a plethora of learning opportunities lies just beyond the classroom. Working collaboratively, a high school science teacher and a snow scientist have developed multiple activities to engage students in the scientific process of collecting, analyzing and interpreting the winter world using snow data to (1) learn about the insulative properties of snow, and (2) to learn about the role of snow cover on winter climate through its reflective properties while participating in a volunteer network that collects snow depth, albedo (reflectivity), and density data. These outdoor field-based snow investigations incorporate Next Generation Science Standards (NGSS) and disciplinary core ideas, including ESS2.C: The roles of water in Earth's surface processes and ESS2.D: Weather and Climate. Additionally, the lesson plans presented address Common Core State Standards (CCSS) in Mathematics, including the creation and analysis of bar graphs and time series plots (CCSS.Math.HSS-ID.A.1) and xy scatter plots (CCSS.Math.HSS-ID.B.6). High school students participating in the 2013/2014 snow sampling season described their outdoor learning experience as "authentic" and "hands-on" as compared to traditional class indoors. They emphasized that learning outdoors was essential to their understanding of underlying content and concepts because they "learn through actual experience."

Using Smartphones to Supplement Classroom Reading

ERIC Educational Resources Information Center

Bromley, Karen

2013-01-01

Supplementing classroom reading with smartphones can develop better vocabulary knowledge, comprehension, technology skills, and writing. This article connects smartphones to reading complex, informational text and the Common Core State Standards (CCSS). The author suggests that smartphones motivate, scaffold comprehension, and invite…

Structural safety assessment for FLNG-LNGC system during offloading operation scenario

NASA Astrophysics Data System (ADS)

Hu, Zhi-qiang; Zhang, Dong-wei; Zhao, Dong-ya; Chen, Gang

2017-04-01

The crashworthiness of the cargo containment systems (CCSs) of a floating liquid natural gas (FLNG) and the side structures in side-by-side offloading operations scenario are studied in this paper. An FLNG vessel is exposed to potential threats from collisions with a liquid natural gas carrier (LNGC) during the offloading operations, which has been confirmed by a model test of FLNG-LNGC side-by-side offloading operations. A nonlinear finite element code LS-DYNA is used to simulate the collision scenarios during the offloading operations. Finite element models of an FLNG vessel and an LNGC are established for the purpose of this study, including a detailed LNG cargo containment system in the FLNG side model. Based on the parameters obtained from the model test and potential dangerous accidents, typical collision scenarios are defined to conduct a comprehensive study. To evaluate the safety of the FLNG vessel, a limit state is proposed based on the structural responses of the LNG CCS. The different characteristics of the structural responses for the primary structural components, energy dissipation and collision forces are obtained for various scenarios. Deformation of the inner hull is found to have a great effect on the responses of the LNG CCS, with approximately 160 mm deformation corresponding to the limit state. Densely arranged web frames can absorb over 35% of the collision energy and be proved to greatly enhance the crashworthiness of the FLNG side structures.

The NASA Innovations in Climate Education Project: 'Instructional Strategies for Expanding Climate Change Concepts within Readng/Literacy Skills

NASA Astrophysics Data System (ADS)

Walton-Jaggers, L. J.; Johnson, D.; Hayden, L. B.; Hale, S. R.

2013-12-01

The Common Core State Standards (CCSS) provide a consistent, clear understanding of what students are expected to learn, so teachers and parents know what they need to do to help them. In 2010 the standards were designed to be robust and relevant to the real world, reflecting the knowledge and skills that young people need for success in college and careers. In 2013 the Next Generation Science Standards (NGSS) in connection with the CCSS developed revised science standards in performance, prior standards documents listed what students should know or understand, foundations were each performance expectation incorporates all three dimensions from a science or engineering practice, a core disciplinary idea, and a crosscutting concept, and coherence that connects each set of performance expectations lists connections to other ideas within the disciplines of science and engineering. Elizabeth City State University (ECSU) in Elizabeth City, North Carolina has joined with the University of New Hampshire (UNH) in Durham, New Hampshire under the NASA Innovations in Climate Education (NICE) grant to empower faculty of education programs at Minority Serving Institutions (MSIs) to better engage their pre-service teachers in teaching and learning about global climate change through the use of NASA Earth observation sets. Specifically, professors from MSIs received training with Global Positioning Systems (GPS) and GES-DISC Interactive Online Visualization And aNalysis Infrastructure (GIOVANNI) to engage pre-service teachers in facets of climate education. Grambling State University faculty members served as participants of the NICE workshop for 2012 and were encouraged to develop lessons in climate education from information shared at the workshop. A corresponding project that incorporated the CCSS and NGSS at Grambling State University in Grambling, Louisiana was headed by Dr. Loretta Jaggers. This paper documents activities that pre-service students in the GSU Curriculum and Instruction Department (College of Education) ED 452-Advanced Seminar Methods course have implemented. Activities included: Critique of Climate Education (oceans) articles, Methodology instruction; and design of a grade specific daily science lesson plan based on Climate Education that focused on El Nino, La Nina, seasonal characteristics of the southern oceans and resources from a NASA NICE workshop packet. Lessons designed were implemented on-site of partner secondary schools. The implementation included a virtual component as Grambling and ECSU students interacted via a polycom environment during reports from ED 452-Advanced Seminar Methods students.

Conditional Survival in Pediatric Malignancies: Analysis of data from the Childhood Cancer Survivor Study and the Surveillance, Epidemiology and End Results Program

PubMed Central

Mertens, Ann C; Yong, Jian; Dietz, Andrew; Kreiter, Erin; Yasui, Yutaka; Bleyer, Archie; Armstrong, Gregory T; Robison, Leslie L; Wasilewski-Masker, Karen

2015-01-01

Background Long-term survivors of pediatric cancer are at risk for life-threatening late effects of their cancer. Previous studies have shown excesses in long-term mortality within high-risk groups defined by demographic and treatment characteristics. Methods To investigate conditional survival in a pediatric cancer population, we performed an analysis of conditional survival in the original Childhood Cancer Survivor Study (CCSS) cohort and the Surveillance, Epidemiology and End Results (SEER) database registry. The overall probability of death for patients in 5 years and 10 years after they survived 5, 10, 15, and 20 years since cancer diagnosis, and cause-specific death in 10 years for 5-year survivors were estimated using the cumulative incidence method. Results Among CCSS and SEER patients who were alive 5 years post cancer diagnosis, within each diagnosis group at least 92% are alive in the subsequent 5 years, except leukemia patients of whom only 88% of 5-year survivors remain alive in the subsequent 5 years. The probability of all-cause mortality in the next 10 years on patients who survived at least 5 years after diagnosis, was 8.8% in CCSS and 10.6% in SEER, approximately three quarter of which were due to neoplasms as causes of death. Conclusion The risk of death of pediatric cancer survivors in 10 years can vary between diagnosis groups by at most 12% even up to 20 years post diagnosis. This information is clinically important in counseling patients on their conditional survival, particularly when survivors are seen in long-term follow-up. PMID:25557134

Effect of clinical use of nickel-titanium springs.

PubMed

Magno, Amanda Fahning; Monini, André da Costa; Capela, Marisa Veiga; Martins, Lídia Parsekian; Martins, Renato Parsekian

2015-07-01

Our objectives were to determine whether there are changes on the load deflection rate (L/DP) and the average force (FP) of the superelastic pseudoplateau, and whether permanent deformation is changed in nickel-titanium closed-coil springs (CCSs) after 6 months of clinical use. Twenty-two nickel-titanium CCSs (Sentalloy 100 g; Dentsply GAC, York, Pa) were subjected to tensile mechanical testing at 37°C on activations varying from 3.2 to 16.0 mm before and after 6 months of clinical use. A regression line was fitted over the most horizontal area of the unloading part of the stress-strain graph of every CCS, and its slope was used as L/DP. The FP was determined by the midpoint of the longest segment of the curve that could be fit within the regression line with a R(2) of at least 0.999, and permanent deformation was determined graphically by obtaining the strain value when the measured stress reached zero. The data were analyzed by 3 analyses of variance at 2 levels, with 5% of significance. Time and activation significantly influenced the variables tested (P < 0.001). Time increased the L/DP and permanent deformation but decreased the FP. Activation decreased L/DP, FP, and permanent deformation. Significant interactions between time and activation were detected for FP (P = 0.013) and deformation (P < 0.001). After 6 months of active clinical use, the analyzed springs had a significant but small increase in their L/DP; FP dropped up to 88%, and the CCSs deformed up to 1.26 mm. Copyright © 2015 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

Individual prediction of heart failure among childhood cancer survivors.

PubMed

Chow, Eric J; Chen, Yan; Kremer, Leontien C; Breslow, Norman E; Hudson, Melissa M; Armstrong, Gregory T; Border, William L; Feijen, Elizabeth A M; Green, Daniel M; Meacham, Lillian R; Meeske, Kathleen A; Mulrooney, Daniel A; Ness, Kirsten K; Oeffinger, Kevin C; Sklar, Charles A; Stovall, Marilyn; van der Pal, Helena J; Weathers, Rita E; Robison, Leslie L; Yasui, Yutaka

2015-02-10

To create clinically useful models that incorporate readily available demographic and cancer treatment characteristics to predict individual risk of heart failure among 5-year survivors of childhood cancer. Survivors in the Childhood Cancer Survivor Study (CCSS) free of significant cardiovascular disease 5 years after cancer diagnosis (n = 13,060) were observed through age 40 years for the development of heart failure (ie, requiring medications or heart transplantation or leading to death). Siblings (n = 4,023) established the baseline population risk. An additional 3,421 survivors from Emma Children's Hospital (Amsterdam, the Netherlands), the National Wilms Tumor Study, and the St Jude Lifetime Cohort Study were used to validate the CCSS prediction models. Heart failure occurred in 285 CCSS participants. Risk scores based on selected exposures (sex, age at cancer diagnosis, and anthracycline and chest radiotherapy doses) achieved an area under the curve of 0.74 and concordance statistic of 0.76 at or through age 40 years. Validation cohort estimates ranged from 0.68 to 0.82. Risk scores were collapsed to form statistically distinct low-, moderate-, and high-risk groups, corresponding to cumulative incidences of heart failure at age 40 years of 0.5% (95% CI, 0.2% to 0.8%), 2.4% (95% CI, 1.8% to 3.0%), and 11.7% (95% CI, 8.8% to 14.5%), respectively. In comparison, siblings had a cumulative incidence of 0.3% (95% CI, 0.1% to 0.5%). Using information available to clinicians soon after completion of childhood cancer therapy, individual risk for subsequent heart failure can be predicted with reasonable accuracy and discrimination. These validated models provide a framework on which to base future screening strategies and interventions. © 2014 by American Society of Clinical Oncology.

Second Language Instructional Competence

ERIC Educational Resources Information Center

Rolstad, Kellie

2017-01-01

Recent developments in education policy in the USA have focused attention on language and literacy, especially for bilingual learners, in US schools. More specifically, these efforts, prominently related to the implementation of the Common Core State Standards (CCSS), focus on the development of "academic English" for immigrant students.…

Methods and Strategies: Ask the Right Question

ERIC Educational Resources Information Center

Kracl, Carrie; Harshbarger, Dena

2017-01-01

Preparing 21st century learners is the goal of both the "Common Core State Standards" ("CCSS") and the "Next Generation Science Standards" ("NGSS"). These two sets of standards jointly illuminate the need to teach scientific and literacy skills that will more appropriately prepare elementary students to…

Quality Matters: Content Literacy for English Language Learners

ERIC Educational Resources Information Center

Zhang, Wei

2017-01-01

The Common Core State Standards (CCSS) require students to read and comprehend complex content texts. They specify three dimensions of a text that simultaneously contribute to text complexity across the curriculum: qualitative dimensions, quantitative dimensions, and reader and task considerations. In literacy instruction, recognizing and…

Imagination in Education

ERIC Educational Resources Information Center

Vaillancourt Menton, Maureen

2015-01-01

Imagination in Education was a qualitative inquiry that explored the effects the implementation of the Common Core State Standards (CCSS) had on imagination within high school cultures. The central question for this study was: How do New York City Department of Education (NYC DOE) high school principals conceptualize imagination within their…

Averted Vision: How Common Core May Help Struggling Readers

ERIC Educational Resources Information Center

Shanahan, Timothy

2016-01-01

In their article "Beyond the Common Core…," Cassidy, Ortlieb, and Grote-Garcia (2016), express concern that the new Common Core State Standards (CCSS; National Governors Association [NGA] Center for Best Practices & Council of Chief State School Officers [CCSSO], 2010) may have the "unintended consequence" of diverting…

Access to the Common Core for All

ERIC Educational Resources Information Center

McLaughlin, Margaret J.

2012-01-01

Too often under the various state-developed standards and assessments, accommodations for students with disabilities--a heterogeneous group with varied characteristics and needs--have not been adequately addressed or have been ignored. The Common Core State Standards (CCSS) initiative provides an historic opportunity to improve access to rigorous…

Organically treated biochar increases plant production and reduces N2O emissions: mechanistic insights by 15N tracing

NASA Astrophysics Data System (ADS)

Kammann, Claudia; Messerschmidt, Nicole; Clough, Tim; Schmidt, Hans-Peter; Marhan, Sven; Koyro, Hans-Werner; Steffens, Diedrich; Müller, Christoph

2014-05-01

Pyrogenic carbon (biochar) offers considerable potential for carbon capture and soil storage (CCSS) compared to other, less recalcitrant soil-C additives. Recent meta-analysis demonstrated that it can significantly reduce agricultural N2O emissions. Freshly produced biochars, however, do not always have yield-improving effects, i.e. there is no immediate economic incentive for using it. Hence, combining biochar with organic nutrient-rich amendments may be a promising agricultural strategy to accelerate CCSS, but it is unclear if biochar still reduces N2O emissions, in particular when it may act as nutrient carrier. We explored the potential of biochar to improve the GHG-cost/yield ratio and thereby its socio-economic value as soil amendment in two subsequent studies under controlled conditions: (1) A proof-of-concept study where the effects of untreated biochar were compared to those of co-composted biochar combined with stepwise improved nutritional regimes (+/- compost; +/- mineral-N application), and (2) a 15N-labeling-tracing study to unravel N exchange on biochar particles and N2O production and reduction mechanisms. Both studies were carried out in nutrient-poor sandy soils, the most likely initial target soils for biochar-CCSS strategies. While the untreated biochar reduced plant growth under N-limiting conditions, or at best did not reduce it, the co-composted biochar always significantly stimulated plant growth. The relative stimulation was largest with the lowest nutrient additions (305% versus 61% of control with untreated biochar). Electro-ultra-filtration analyses revealed that the co-composted but not the untreated biochar carried considerable amounts of easily extractable as well as more strongly sorbed plant nutrients, in particular nitrate and phosphorus. The subsequent 15N labelling-tracing study revealed that the co-composted biochar still (i) acted as a mineral-N exchange site for nitrate and ammonium despite its N-preloading, (ii) reduced N2O emissions significantly, although it carried dissolved organic carbon and nitrate as prerequisites for denitrification; and that it thus (iii) significantly improved the GHG-cost/yield ratio of plant production. Our results therefore encourage further investigations on strategies where nutrient-rich agricultural waste streams are combined with biochar post-treatment. Cascading use of biochar in agriculture may have the potential to evolve into a key CCSS technology to turn agriculture from being part of the problem into being part of the solution.

Impact of bias correction and downscaling through quantile mapping on simulated climate change signal: a case study over Central Italy

NASA Astrophysics Data System (ADS)

Sangelantoni, Lorenzo; Russo, Aniello; Gennaretti, Fabio

2018-02-01

Quantile mapping (QM) represents a common post-processing technique used to connect climate simulations to impact studies at different spatial scales. Depending on the simulation-observation spatial scale mismatch, QM can be used for two different applications. The first application uses only the bias correction component, establishing transfer functions between observations and simulations at similar spatial scales. The second application includes a statistical downscaling component when point-scale observations are considered. However, knowledge of alterations to climate change signal (CCS) resulting from these two applications is limited. This study investigates QM impacts on the original temperature and precipitation CCSs when applied according to a bias correction only (BC-only) and a bias correction plus downscaling (BC + DS) application over reference stations in Central Italy. BC-only application is used to adjust regional climate model (RCM) simulations having the same resolution as the observation grid. QM BC + DS application adjusts the same simulations to point-wise observations. QM applications alter CCS mainly for temperature. BC-only application produces a CCS of the median 1 °C lower than the original ( 4.5 °C). BC + DS application produces CCS closer to the original, except over the summer 95th percentile, where substantial amplification of the original CCS resulted. The impacts of the two applications are connected to the ratio between the observed and the simulated standard deviation (STD) of the calibration period. For the precipitation, original CCS is essentially preserved in both applications. Yet, calibration period STD ratio cannot predict QM impact on the precipitation CCS when simulated STD and mean are similarly misrepresented.

Paraphrasing Strategy Instruction in Content Area Text

ERIC Educational Resources Information Center

Hagaman, Jessica L.; Casey, Kathryn J.

2017-01-01

Reading comprehension is important for academic success and is a skill required for many activities in school and beyond. With the implementation of the Common Core State Standards (CCSS), many teachers have reported feeling overwhelmed by the expectations that reading and writing skills should be emphasized, taught, and supported in the content…

Challenging Perspectives on Young Adult Literature

ERIC Educational Resources Information Center

Conners, Sean P.

2013-01-01

As proponents of the Common Core State Standards (CCSS) publish lists of "Exemplar Texts" that are said to represent the degree of textual complexity appropriate for the different grade levels, and that are overwhelmingly canonical, those who value young adult literature and recognize a place for it in the high school literature…

Creating and Using VMCAnalytics for Preservice Teachers' Studying of Argumentation

ERIC Educational Resources Information Center

Van Ness, Cheryl K.

2017-01-01

Teacher recognition of student argumentation has been addressed by many researchers (e.g., Schwarz, 2009; Krummheuer, 1995; Bieda & Lepak, 2014; Whitenack & Yackel, 2002). Further, standards for mathematics learning emphasize the importance of including argumentation in the K-12 classroom (NCTM, 2000; CCSS, 2010). The study reported here…

Recognizing the Political in Implementation Research

ERIC Educational Resources Information Center

McDonnell, Lorraine M.; Weatherford, M. Stephen

2016-01-01

The widely publicized opposition to the implementation of the Common Core State Standards (CCSS) is in marked contrast to its relatively uncontroversial development and adoption--a contrast that points to the importance of understanding how the politics of enactment differs from the politics of implementation. In this article, we draw on the…

Beyond the Classroom

ERIC Educational Resources Information Center

Smith, Malbert III; Schiano, Anne; Lattanzio, Elizabeth

2014-01-01

We are at a transformative moment in education with the almost universal adoption (forty-five states, the District of Columbia, and four territories) of the Common Core State Standards (CCSS). As we move from adoption to implementation of these standards across the country, the climate for educational reform has led to expectations of change that…

What's Hot: Texas and the Nation

ERIC Educational Resources Information Center

Cassidy, Jack; Ortlieb, Evan; Grote-Garcia, Stephanie

2016-01-01

For two decades the International Literacy Association (ILA) has published the "What's Hot, What's Not in Literacy Survey." In the last five years, the hottest topics featured on the lists have largely been connected to the English Language Arts Common Core State Standards (ELA CCSS)--a publication produced by the National Governors…

Using Generic Examples to Make Viable Arguments

ERIC Educational Resources Information Center

Adams, Anne E.; Ely, Rob; Yopp, David

2017-01-01

The twenty-first century has seen an increased call to train students to craft mathematical arguments. The third of the Common Core's (CCSS) Standards for Mathematical Practice (SMP 3) (CCSSI 2010) calls for all mathematically proficient students to "construct viable arguments" to support the truth of their ideas and to "critique…

Teacher Leadership--Connecting Learning to Practice

ERIC Educational Resources Information Center

Coughlan, Margaret

2015-01-01

The Common Core State Standards (CCSS, 2010) as the latest initiative in the ongoing effort of educational reform in the United States reinforces the need to build the capacity of teachers as leaders and change agents. As such, graduate teacher leadership programs function to support and develop teacher leadership praxis. Although studies of…

Strengthening the Mind's Eye

ERIC Educational Resources Information Center

Berninger, Virginia Wise

2012-01-01

"If it's not tested, it doesn't get taught" is the prevailing belief that guides many educators' practice of only teaching skills that are addressed in the latest governing standards. Most states have now adopted the Common Core State Standards (CCSS), which don't cover handwriting or spelling. Consequently, some states and school districts have…

The State's Priority Opportunities to Support Education Reform in Georgia through Resource Reallocation

ERIC Educational Resources Information Center

Education Resource Strategies, 2014

2014-01-01

Nationwide, states face declining or plateauing investments in education. These financial constraints, coupled with increased standards for student achievement through the widespread adoption of the Common Core State Standards (CCSS), create a heightened need for strategic resource use. However, districts are not currently using resources…

Revisiting Mr. Tall and Mr. Short

ERIC Educational Resources Information Center

Riehl, Suzanne M.; Steinthorsdottir, Olof Bjorg

2014-01-01

Ratio, rate, and proportion are central ideas in the Common Core State Standards (CCSS) for middle-grades mathematics (CCSSI 2010). These ideas closely connect to themes in earlier grades (pattern building, multiplicative reasoning, rational number concepts) and are the foundation for understanding linear functions as well as many high school…

Rhetorical Reading as a Gateway to Disciplinary Literacy

ERIC Educational Resources Information Center

Warren, James E.

2013-01-01

The Common Core State Standards (CCSS) require literacy instruction for secondary students across content areas, but they also recommend that this instruction account for the discipline-specific nature of academic texts. Since English language arts (ELA) teachers and literacy specialists are also responsible for teaching students to read across…

Methods and Strategies: Science Notebooks as Learning Tools

ERIC Educational Resources Information Center

Fulton, Lori

2017-01-01

Writing in science is a natural way to integrate science and literacy and meet the goals set by the "Next Generation Science Standards" ("NGSS") and the "Common Core State Standards" ("CCSS"), which call for learners to be engaged with the language of science. This means that students should record…

The Unrelenting Search for a Quick Fix

ERIC Educational Resources Information Center

Marinak, Barbara A.

2016-01-01

Cassidy, Ortlieb, and Grote-Garcia (2016) have penned an important and insightful article. This reflection on the impact of the Common Core State Standards (CCSS; National Governors Association [NGA] Center for Best Practices & Council of Chief State School Officers [CCSSO], 2010) through the lens of "What's Hot, What's Not" for two…

FIVES: An Integrated Strategy for Comprehension and Vocabulary Learning

ERIC Educational Resources Information Center

Shea, Mary; Roberts, Nancy

2016-01-01

This article describes a strategy that emphasizes the integration of all language and literacy skills for learning across content areas as well as the importance CCSS place on learners' ability to ask questions about information, phenomena, or ideas encountered (Ciardiello, 2012/2013). FIVES is a strategy that meaningfully integrates…

The Changing Science Curriculum

ERIC Educational Resources Information Center

Ediger, Marlow

2014-01-01

Science, as a curriculum area, has gone through many changes recently with the oncoming of the Common Core State Standards (CCSS), Science, Technology, Engineering, and Mathematics (STEM), as well as the Next Generation Science Standards (NGSS). Science is a part of everyday life which individuals experience. Even the drying up of a puddle of…

Elementary Teacher Perceptions Regarding the Use of Kinesthetic Learning Strategies

ERIC Educational Resources Information Center

Erickson, Heidi Christine

2017-01-01

Researchers have shown that movement increases brain function, improves mental health, supports cognitive development for students, and reduces sedentary time, all which can influence overall health. Research concerning learning with intentional movement is limited. In the United States, Common Core State Standards (CCSS) are being mandated, and…

It's the Teacher, Stupid

ERIC Educational Resources Information Center

Fletcher, Geoffrey H.

2012-01-01

The author has taken the liberty of borrowing from past candidate (and president) Bill Clinton's "War Room" mantra to suggest that those who are working toward preparing schools for online assessments of Common Core State Standards (CCSS) might be forgetting the most important element in the process: the classroom teacher. The author argues that…

The Right Time to Start Writing

ERIC Educational Resources Information Center

Casa, Tutita M.

2015-01-01

Communication has long been emphasized in standards-based instruction (NCTM 1991; 2000), yet little distinction has been made between oral and written forms. Nonetheless, both the mathematics and the English language arts Common Core State Standards (CCSS) documents continue to hint at the importance of writing mathematically (CCSSI 2010). The…

Using Genre Pedagogy to Teach Adolescent English Learners to Write Academic Persuasive Essays

ERIC Educational Resources Information Center

Ramos, Kathleen Ann

2015-01-01

The new "Common Core State Standards" (CCSS) (NGACBP & CCSSO, 2010) require teachers to prepare all learners, including adolescent English learners (ELs), to develop academic literacy practices. This article describes an instructional intervention in an urban public high school using the genre-based "Reading to Learn" (Rose…

Using Professional Learning Communities to Bolster Comprehension Instruction

ERIC Educational Resources Information Center

Dougherty Stahl, Katherine A.

2015-01-01

High-level comprehension instruction is the focus of the Common Core State Standards in English Language Arts. However, it has been a challenge for states to provide the professional development (PD) needed to support teachers' implementation of the CCSS. Professional learning communities (PLC) are a means of providing school-embedded PD to…

What Research Says about Text Complexity and Learning to Read

ERIC Educational Resources Information Center

Allington, Richard L.; McCuiston, Kimberly; Billen, Monica

2015-01-01

The CCSS framework indicates more difficult texts are to be used with students. However, the rationale for increasing text difficulty, decreasing text difficulty, is unsupported by the research that shows texts have been increasing in difficulty for at least 50 years. Oral reading accuracy is a traditional method of estimating text difficulty. For…

Exploring the Sources of Turkish Pre-Service Chemistry Teachers' Chemistry Self-Efficacy Beliefs

ERIC Educational Resources Information Center

Uzuntiryaki, Esen

2008-01-01

This study aimed to examine the underlying sources in developing chemistry self-efficacy beliefs of Turkish pre-service chemistry teachers. For this purpose, the College Chemistry Selfefficacy Scale (CCSS) was administered to 20 pre-service chemistry teachers. Then, phenomenological approach was employed and semi-structured interviews were…

Voter Perceptions: Common Core State Standards & Tests

ERIC Educational Resources Information Center

Achieve, Inc., 2014

2014-01-01

Since June 2010, 46 states and Washington DC have adopted the Common Core State Standards (CCSS)--K-12 standards in mathematics and English language arts/literacy developed through a multi-state initiative led by the National Governors Association and the Council of Chief State School Officers. Implementation of the standards is underway in all of…

Addressing the Standards for Mathematical Practice in a Calculus Class

ERIC Educational Resources Information Center

Pilgrim, Mary E.

2014-01-01

The Common Core State Standards (CCSS) provide teachers with the expectations and requirements that are meant to prepare K-12 students for college and the workforce (CCSSI 2010b). The Common Core State Standards for Mathematical Practice (SMPs) emphasize the development of skills and conceptual understanding for students to become proficient in…

The Development of a Cognitively-Diagnostic Formative Assessment of the Early Concept of Angle

ERIC Educational Resources Information Center

Khasanova, Elvira

2016-01-01

Students' development of conceptual understandings is a central goal of mathematics education (CCSS-Mathematics, 2010). Such a challenging, yet ambiguous, goal cannot be achieved without empowering teachers with the knowledge and tools critical for their ability to adequately convey the content, and assess and interpret students' performance. This…

Implementation of Common Core State Standards: Voices, Positions, and Frames

ERIC Educational Resources Information Center

Pense, Seburn L.; Freeburg, Beth Winfrey; Clemons, Christopher A.

2015-01-01

The purpose of this study was to describe the voices heard, positions portrayed, and frames of newspaper messages regarding the implementation of Common Core State Standards (CCSS). The dataset contained 69 articles from 38 community newspapers in 24 states (n = 62) and from three national newspapers (n = 7). Researchers identified five voices…

Robust Implementation of MDC: Teacher Perceptions of Tool Use and Outcomes. Brief Three

ERIC Educational Resources Information Center

Lawrence, Nancy; Sanders, Felicia

2012-01-01

The Bill and Melinda Gates Foundation has invested in the development and dissemination of high-quality instructional and formative assessment tools to support teachers' incorporation of the Common Core State Standards (CCSS) into their classroom instruction. Lessons from the first generation of standards-based reforms suggest that intense…

Robust Implementation of LDC: Teacher Perceptions of Tool Use and Outcomes. Brief Two

ERIC Educational Resources Information Center

Reumann-Moore, Rebecca; Sanders, Felicia

2012-01-01

The Bill and Melinda Gates Foundation has invested in the development and dissemination of high-quality instructional and formative assessment tools to support teachers' incorporation of the Common Core State Standards (CCSS) into their classroom instruction. Lessons from the first generation of standards-based reforms suggest that intense…

Organized Interests and the Common Core

ERIC Educational Resources Information Center

McDonnell, Lorraine M.; Weatherford, M. Stephen

2013-01-01

Among the notable aspects of the Common Core State Standards (CCSS) is the diverse array of interest groups supporting them. These organizations must now apply the strategies they used so effectively in advancing the Common Core to stem mounting opposition to it. This article draws on theories of political and policy learning and interviews with…

iLEAP Assessment Guide-Revised. Grade 6: English Language Arts, Math, Science, Social Studies

ERIC Educational Resources Information Center

Louisiana Department of Education, 2012

2012-01-01

"Louisiana Believes" embraces the principle that all children can achieve at high levels, as evidenced in Louisiana's recent adoption of the Common Core State Standards (CCSS). "Louisiana Believes" also promotes the idea that Louisiana's educators should be empowered to make decisions to support the success of their students.…

iLEAP Assessment Guide-Revised. Grade 3: English Language Arts, Math, Science, Social Studies

ERIC Educational Resources Information Center

Louisiana Department of Education, 2012

2012-01-01

"Louisiana Believes" embraces the principle that all children can achieve at high levels, as evidenced in Louisiana's recent adoption of the Common Core State Standards (CCSS). "Louisiana Believes" also promotes the idea that Louisiana's educators should be empowered to make decisions to support the success of their students.…

iLEAP Assessment Guide-Revised Grade 7: English Language Arts, Math, Science, Social Studies

ERIC Educational Resources Information Center

Louisiana Department of Education, 2012

2012-01-01

"Louisiana Believes" embraces the principle that all children can achieve at high levels, as evidenced in Louisiana's recent adoption of the Common Core State Standards (CCSS). "Louisiana Believes" also promotes the idea that Louisiana's educators should be empowered to make decisions to support the success of their students.…

iLEAP Assessment Guide-Revised, Grade 5: English Language Arts, Math, Science, Social Studies

ERIC Educational Resources Information Center

Louisiana Department of Education, 2012

2012-01-01

"Louisiana Believes" embraces the principle that all children can achieve at high levels, as evidenced in Louisiana's recent adoption of the Common Core State Standards (CCSS). "Louisiana Believes" also promotes the idea that Louisiana's educators should be empowered to make decisions to support the success of their students.…

LEAP Assessment Guide. Grade 8: English Language Arts, Mathematics, Science, Social Studies

ERIC Educational Resources Information Center

Louisiana Department of Education, 2012

2012-01-01

"Louisiana Believes” embraces the principle that all children can achieve at high levels, as evidenced in Louisiana's recent adoption of the Common Core State Standards (CCSS). "Louisiana Believes" also promotes the idea that Louisiana's educators should be empowered to make decisions to support the success of their students. In…

Teachers' Perceptions about the Common Core State Standards in Writing

ERIC Educational Resources Information Center

Hall, Anna H.; Hutchison, Amy; White, Kelley Mayer

2015-01-01

This article describes findings from a survey completed by 250 K-12th grade teachers from eight states (i.e., Kentucky, Minnesota, Michigan, Maine, Delaware, North Carolina, Georgia, and Mississippi) that had fully implemented the Common Core State Standards (CCSS) by spring 2013. The survey was designed to examine teachers' perceptions about…

State Support for Open Educational Resources: Key Findings from Achieve's OER Institute

ERIC Educational Resources Information Center

Achieve, Inc., 2013

2013-01-01

Open Educational Resources (OER) offer unique new opportunities for educators to share quality learning resources, especially in an increasingly digital world. Forty-six states and the District of Columbia have adopted the Common Core State Standards (CCSS), providing them with the unprecedented advantage of being able to share resources that are…

Teaching Adolescent ELs to Write Academic-Style Persuasive Essays

ERIC Educational Resources Information Center

Ramos, Kathleen

2014-01-01

The wide adoption of the new Common Core State Standards (CCSS) in the U.S. has increased expectations for all teachers to prepare all learners to read and write in academic ways. More knowledge is needed about instructional approaches that may lead adolescent English learners (ELs) to meet this goal. Developing academic literacy practices…

Simplifying the ELA Common Core; Demystifying Curriculum

ERIC Educational Resources Information Center

Schmoker, Mike; Jago, Carol

2013-01-01

The English Language Arts (ELA) Common Core State Standards ([CCSS], 2010) could have a transformational effect on American education. Though the process seems daunting, one can begin immediately integrating the essence of the ELA Common Core in every subject area. This article shows how one could implement the Common Core and create coherent,…

Scaffolded Silent Reading (ScSR): Advocating a Policy for Adolescents' Independent Reading

ERIC Educational Resources Information Center

Walker, Karen P.

2013-01-01

Structured independent reading among students is often a vital missing component in many school districts' literacy curriculum. The nationwide implementation of the Common Core State Standards (CCSS) requires districts to re-think their literacy curriculum and what instruction might entail in order for students to demonstrate proficiency in…

Slicing and Dicing the ELA Common Core Standards

ERIC Educational Resources Information Center

Goatley, Virginia

2012-01-01

The English Language Arts Common Core State Standards (ELA CCSS) come at a time when many reading teachers, literacy coaches, and classroom teachers seek more extensive literacy practices than the policy mandates of No Child Left Behind and Reading First. These initiatives placed requirements for instruction in core aspects of reading at the…

Impact Evaluation of National Writing Project Professional Development Program

ERIC Educational Resources Information Center

Gallagher, H. Alix; Woodworth, Katrina; McCaffrey, Teresa; Park, Christina J.; Wang, Haiwen

2014-01-01

Improving teacher effectiveness is a key strategy to ensure student readiness for college and careers and to address achievement gaps and persistent low performance. In response to the new Common Core State Standards for English Language Arts (CCSS-ELA) the National Writing Project (NWP) created a professional development (PD) program to support…

Modeling in the Common Core State Standards

ERIC Educational Resources Information Center

Tam, Kai Chung

2011-01-01

The inclusion of modeling and applications into the mathematics curriculum has proven to be a challenging task over the last fifty years. The Common Core State Standards (CCSS) has made mathematical modeling both one of its Standards for Mathematical Practice and one of its Conceptual Categories. This article discusses the need for mathematical…

Common Core, Commonplaces, and Community in Teaching Reading

ERIC Educational Resources Information Center

Roskos, Kathleen; Neuman, Susan B.

2013-01-01

Joseph Schwab, a curriculum theorist, described four commonplaces, or universals, of teaching: content, students, milieu and teachers. This article considers how the Reading Standards of the ELA-CCSS are shaping these commonplaces in the teaching of reading. The organization of the Reading Standards, for example, focuses on two broad grade bands,…

The Common Core "State" Standards: The Arts and Education Reform

ERIC Educational Resources Information Center

Wexler, Alice

2014-01-01

In this commentary, Alice Wexler notes that as the Common Core State Standards (CCSS) become reality, teachers have reason for concern. She contends that this reform to public education has consequently marginalized the arts and exacerbated the inequities of people in poverty and those with disabilities. Teachers, principals and, ultimately,…

Text Complexity and Young Adult Literature: Establishing Its Place

ERIC Educational Resources Information Center

Glaus, Marci

2014-01-01

Preparing students for college and careers in the 21st century has shed light on text complexity as an important variable for consideration in English Language Arts. Authors of The Common Core State Standards (CCSS) define text complexity as broad, highlighting qualitative, rather than quantitative evaluations of narrative fiction as appropriate…

Designing California's Next School Accountability Program

ERIC Educational Resources Information Center

Warren, Paul

2014-01-01

California is in the midst of a major K-12 reform effort. In 2010, the state adopted the Common Core State Standards (CCSS), which outline what students should know in mathematics and English. In 2013, it adopted tests of the new standards developed by the Smarter Balanced Assessment Collaborative (SBAC). These tests will be administered beginning…

Common Core Standards: The Emperor Has No Clothes, or Evidence

ERIC Educational Resources Information Center

Tienken, Christopher H.

2011-01-01

The Common Core State Standards (CCSS) initiative continues to gather strength. But the evidence presented by its developers--the National Governors Association (NGA) and the Council of Chief State School Officers (CCSSO)--seems lacking compared to the independent reviews and the available research on the topic that suggest otherwise. In this…

Common Core State Standards: I Wonder?

ERIC Educational Resources Information Center

Tienken, Christopher H.

2010-01-01

On June 1, 2009, the National Governors Association Center for Best Practices (NGA Center) and the Council of Chief State School Officers (CCSSO) issued a press release stating that 49 states and territories had joined the Common Core State Standards Initiative (CCSS). That initiative proposed that all states voluntarily adopt the same set of…

Common Core State Standards Assessments: Challenges and Opportunities

ERIC Educational Resources Information Center

Polikoff, Morgan S.

2014-01-01

The Common Core State Standards (CCSS) were created in response to the shortcomings of No Child Left Behind era standards and assessments. Among those failings were the poor quality of content standards and assessments and the variability in content expectations and proficiency targets across states, as well as concerns related to the economic…

Standards, Assessment, and Readiness: Addressing Postsecondary Transition Issues across State Lines

ERIC Educational Resources Information Center

Michelau, Demarée K.

2015-01-01

This brief describes major challenges ahead for states, institutions, and most importantly, students as the standards and assessments from the Common Core Standards (CCSS) are implemented. It also offers recommendations to create a network structure that would assist K-12 and higher education leaders in addressing those challenges. To begin the…

Common Core State Standards 101

ERIC Educational Resources Information Center

Rothman, Robert

2013-01-01

The Common Core State Standards (CCSS) represent the first time that nearly every state has set common expectations for what students should know and be able to do. In the past, each state set its own standards, and the results varied widely. And while states collectively developed these common standards, decisions about the curriculum and…

Advancing Multicultural Education: New Historicism in the High School English Classroom

ERIC Educational Resources Information Center

Li, Sidney C.

2015-01-01

High schools across the country are restructuring their curricular frameworks to meet the new Common Core State Standards (CCSS), which emphasize an understanding of cultural diversity in addition to critical thinking and literacy. Despite curricular variance among high schools, the significant roles non-white races have played in constructing a…

Common Core State Standards: Implementation Tools and Resources

ERIC Educational Resources Information Center

Council of Chief State School Officers, 2013

2013-01-01

The Council of Chief State School Officers (CCSSO or the Council) developed this list of free tools and resources to support state education agencies, districts, and educators during the process of implementing the Common Core State Standards (CCSS). This document primarily lists resources developed by CCSSO and other leading organizations and is…

The Common Core State Standards: The Emperor Is Still Looking for His Clothes

ERIC Educational Resources Information Center

Tienken, Christopher H.

2012-01-01

As of September 2012, only Alaska, Minnesota, Nebraska, Texas, and Virginia had not adopted the Common Core State Standards (CCSS). Yet empirical evidence that demonstrates the efficacy of the initiative remains elusive. The Emperor has no clothes (Tienken 2011a). This latest installment of standardization and centralization of curriculum and…

Principals as Partners in Change: Insights on Common Core State Standards Implementation

ERIC Educational Resources Information Center

Lucas, Brian

2017-01-01

Since the introduction of the Common Core State Standards (CCSS) in 2010, the education world has experienced a paradigm shift in the pedagogical expectations of educators, and there have been a decidedly mixed results on the implementation of the new standards. This qualitative study explored the experiences of several school administrators…

What Is "Repeated Reasoning" in MP 8?

ERIC Educational Resources Information Center

Goldenberg, E. Paul; Carter, Cynthia J.; Mark, June; Nikula, Johannah; Spencer, Deborah B.

2017-01-01

The Common Core State Standards (CCSSI 2010) for Mathematical Practice have relevance even for those not in CCSS states because they describe the habits of mind that mathematicians--professionals as well as proficient school-age learners--use when doing mathematics. They provide a language to discuss aspects of mathematical practice that are of…

Engaging Educators: Common Core State Standards Implementation

ERIC Educational Resources Information Center

Achieve, Inc., 2011

2011-01-01

To date, 44 states and the District of Columbia have adopted the Common Core State Standards (CCSS). Achieve has prepared this planning document to help all states in the American Diploma Project Network (ADP) and the Partnership for Assessment of Readiness for College and Careers (PARCC) consortium engage educators in the essential work of…

Technology and Engineering Education and the Common Core Standards

ERIC Educational Resources Information Center

Rust, Terrie

2012-01-01

The nearly unanimous state acceptance of the Common Core State Standards (CCSS) in mathematics and English Language Arts (ELA) jolted many teachers out of their complacency. How was this major change going to impact their teaching and their curriculum? What changes would be made in student assessments and teacher accountability? The good news is…

Supporting Kindergartners' Science Talk in the Context of an Integrated Science and Disciplinary Literacy Curriculum

ERIC Educational Resources Information Center

Wright, Tanya S.; Gotwals, Amelia Wenk

2017-01-01

Given the growing evidence of limited attention to science, disciplinary literacy, and oral language in elementary classrooms serving low-income children, this study focused on designing and testing an integrated science and disciplinary language and literacy curriculum aligned with NGSS and CCSS ELA standards for kindergarten. We used…

Engaging Minds in the Common Core: Integrating Standards for Student Engagement

ERIC Educational Resources Information Center

Howard, Christy

2016-01-01

With the implementation of Common Core State Standards (CCSS) many teachers continue to search for ways to engage students in the learning process while meeting the rigorous demands of the standards. Researchers suggest that by providing opportunities for higher order thinking, student choice, and creative ways to showcase knowledge, students will…

Relating Aspects of Motivation to Facets of Mathematical Competence Varying in Cognitive Demand

ERIC Educational Resources Information Center

Gilbert, Melissa C.

2016-01-01

The author investigated the relationship between aspects of student motivation and performance on mathematical tasks varying in cognitive demand relevant to meeting the expectations of the Common Core State Standards for Mathematics (CCSS-M). A sample of 479 primarily Latino middle school students completed established survey measures of…

Translating the Common Core State Standards

ERIC Educational Resources Information Center

Tienken, Christopher H.; Orlich, Donald C.

2013-01-01

As the authors describe in Chapter 7 of their new book, "The School Reform Landscape: Fraud, Myth, and Lies," the Common Core State Standards (CCSS) initiative continues to ramble on, without evidence to support its efficacy. That is because education reform in the United States is being driven largely by ideology, rhetoric, and dogma instead of…

A Youth Suicide Prevention Plan for Canada: A Systematic Review of Reviews.

PubMed

Bennett, Kathryn; Rhodes, Anne E; Duda, Stephanie; Cheung, Amy H; Manassis, Katharina; Links, Paul; Mushquash, Christopher; Braunberger, Peter; Newton, Amanda S; Kutcher, Stanley; Bridge, Jeffrey A; Santos, Robert G; Manion, Ian G; Mclennan, John D; Bagnell, Alexa; Lipman, Ellen; Rice, Maureen; Szatmari, Peter

2015-06-01

We conducted an expedited knowledge synthesis (EKS) to facilitate evidence-informed decision making concerning youth suicide prevention, specifically school-based strategies and nonschool-based interventions designed to prevent repeat attempts. Systematic review of review methods were applied. Inclusion criteria were as follows: systematic review or meta-analysis; prevention in youth 0 to 24 years; peer-reviewed English literature. Review quality was determined with AMSTAR (a measurement tool to assess systematic reviews). Nominal group methods quantified consensus on recommendations derived from the findings. No included review addressing school-based prevention (n = 7) reported decreased suicide death rates based on randomized controlled trials (RCTs) or controlled cohort studies (CCSs), but reduced suicide attempts, suicidal ideation, and proxy measures of suicide risk were reported (based on RCTs and CCSs). Included reviews addressing prevention of repeat suicide attempts (n = 14) found the following: emergency department transition programs may reduce suicide deaths, hospitalizations, and treatment nonadherence (based on RCTs and CCSs); training primary care providers in depression treatment may reduce repeated attempts (based on one RCT); antidepressants may increase short-term suicide risk in some patients (based on RCTs and meta-analyses); this increase is offset by overall population-based reductions in suicide associated with antidepressant treatment of youth depression (based on observational studies); and prevention with psychosocial interventions requires further evaluation. No review addressed sex or gender differences systematically, Aboriginal youth as a special population, harm, or cost-effectiveness. Consensus on 6 recommendations ranged from 73% to 100%. Our EKS facilitates decision maker access to what is known about effective youth suicide prevention interventions. A national research-to-practice network that links researchers and decision makers is recommended to implement and evaluate promising interventions; to eliminate the use of ineffective or harmful interventions; and to clarify prevention intervention effects on death by suicide, suicide attempts, and suicidal ideation. Such a network could position Canada as a leader in youth suicide prevention.

A Youth Suicide Prevention Plan for Canada: A Systematic Review of Reviews

PubMed Central

Bennett, Kathryn; Rhodes, Anne E; Duda, Stephanie; Cheung, Amy H; Manassis, Katharina; Links, Paul; Mushquash, Christopher; Braunberger, Peter; Newton, Amanda S; Kutcher, Stanley; Bridge, Jeffrey A; Santos, Robert G; Manion, Ian G; McLennan, John D; Bagnell, Alexa; Lipman, Ellen; Rice, Maureen; Szatmari, Peter

2015-01-01

Objective: We conducted an expedited knowledge synthesis (EKS) to facilitate evidence-informed decision making concerning youth suicide prevention, specifically school-based strategies and nonschool-based interventions designed to prevent repeat attempts. Methods: Systematic review of review methods were applied. Inclusion criteria were as follows: systematic review or meta-analysis; prevention in youth 0 to 24 years; peer-reviewed English literature. Review quality was determined with AMSTAR (a measurement tool to assess systematic reviews). Nominal group methods quantified consensus on recommendations derived from the findings. Results: No included review addressing school-based prevention (n = 7) reported decreased suicide death rates based on randomized controlled trials (RCTs) or controlled cohort studies (CCSs), but reduced suicide attempts, suicidal ideation, and proxy measures of suicide risk were reported (based on RCTs and CCSs). Included reviews addressing prevention of repeat suicide attempts (n = 14) found the following: emergency department transition programs may reduce suicide deaths, hospitalizations, and treatment nonadherence (based on RCTs and CCSs); training primary care providers in depression treatment may reduce repeated attempts (based on one RCT); antidepressants may increase short-term suicide risk in some patients (based on RCTs and meta-analyses); this increase is offset by overall population-based reductions in suicide associated with antidepressant treatment of youth depression (based on observational studies); and prevention with psychosocial interventions requires further evaluation. No review addressed sex or gender differences systematically, Aboriginal youth as a special population, harm, or cost-effectiveness. Consensus on 6 recommendations ranged from 73% to 100%. Conclusions: Our EKS facilitates decision maker access to what is known about effective youth suicide prevention interventions. A national research-to-practice network that links researchers and decision makers is recommended to implement and evaluate promising interventions; to eliminate the use of ineffective or harmful interventions; and to clarify prevention intervention effects on death by suicide, suicide attempts, and suicidal ideation. Such a network could position Canada as a leader in youth suicide prevention. PMID:26175322

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

PubMed Central

Taylor, Marcus J.; Perrais, David; Merrifield, Christien J.

2011-01-01

Dual colour total internal reflection fluorescence microscopy is a powerful tool for decoding the molecular dynamics of clathrin-mediated endocytosis (CME). Typically, the recruitment of a fluorescent protein–tagged endocytic protein was referenced to the disappearance of spot-like clathrin-coated structure (CCS), but the precision of spot-like CCS disappearance as a marker for canonical CME remained unknown. Here we have used an imaging assay based on total internal reflection fluorescence microscopy to detect scission events with a resolution of ∼2 s. We found that scission events engulfed comparable amounts of transferrin receptor cargo at CCSs of different sizes and CCS did not always disappear following scission. We measured the recruitment dynamics of 34 types of endocytic protein to scission events: Abp1, ACK1, amphiphysin1, APPL1, Arp3, BIN1, CALM, CIP4, clathrin light chain (Clc), cofilin, coronin1B, cortactin, dynamin1/2, endophilin2, Eps15, Eps8, epsin2, FBP17, FCHo1/2, GAK, Hip1R, lifeAct, mu2 subunit of the AP2 complex, myosin1E, myosin6, NECAP, N-WASP, OCRL1, Rab5, SNX9, synaptojanin2β1, and syndapin2. For each protein we aligned ∼1,000 recruitment profiles to their respective scission events and constructed characteristic “recruitment signatures” that were grouped, as for yeast, to reveal the modular organization of mammalian CME. A detailed analysis revealed the unanticipated recruitment dynamics of SNX9, FBP17, and CIP4 and showed that the same set of proteins was recruited, in the same order, to scission events at CCSs of different sizes and lifetimes. Collectively these data reveal the fine-grained temporal structure of CME and suggest a simplified canonical model of mammalian CME in which the same core mechanism of CME, involving actin, operates at CCSs of diverse sizes and lifetimes. PMID:21445324

Syntactic Complexity as an Aspect of Text Complexity

ERIC Educational Resources Information Center

Frantz, Roger S.; Starr, Laura E.; Bailey, Alison L.

2015-01-01

Students' ability to read complex texts is emphasized in the Common Core State Standards (CCSS) for English Language Arts and Literacy. The standards propose a three-part model for measuring text complexity. Although the model presents a robust means for determining text complexity based on a variety of features inherent to a text as well as…

The Common Core State Standards and Evidence-Based Educational Practices: The Case of Writing

ERIC Educational Resources Information Center

Troia, Gary A.; Olinghouse, Natalie G.

2013-01-01

Although writing plays an important role in the academic, psychosocial, and economic success of individuals, typical writing instruction and assessment in the United States generally does not reflect evidence-based practices. The Common Core State Standards (CCSS) place a great deal of emphasis on written expression and may encourage an increased…

The Common Core State Standards: Comparisons of Access and Quality

ERIC Educational Resources Information Center

Wasserman, Nicholas H.

2011-01-01

Last year the United States unveiled the Common Core State Standards (CCSS) in English and Mathematics for grades K-12. In particular, the authors included two possible sequences of 8-12 mathematics courses that would fulfill the standards. Most notably, the courses titled "3a" and "3b" in these two sequences have become…

Strategies for Creating Work-Based Learning Experiences in Schools for Secondary Students with Disabilities

ERIC Educational Resources Information Center

Cease-Cook, Jennifer; Fowler, Catherine; Test, David W.

2015-01-01

Nationally, the recent focus has been on adopting state-developed standards in English language arts (ELA) and mathematics that build toward college and career readiness. Of the states that have elected to adopt the Common Core State Standards (CCSS; National Governors Association, Council of Chief State School Officers, 2012), states either (a)…

A Case for Common Core State Standards: Gifted Curriculum 3.0

ERIC Educational Resources Information Center

VanTassel-Baska, Joyce

2012-01-01

The Common Core State Standards (CCSS) is the most successful attempt to gain consensus across states for 21st century standards in language arts and mathematics. So far, 46 states have accepted these standards, with two consortia organized to translate them into resources and sample activities. A consultant firm has been hired to develop the…

Facilitating Middle Level Pre-Service Teachers' Literacy Integration in Early Field Experiences

ERIC Educational Resources Information Center

Leckie, Alisa; Wall, Amanda

2016-01-01

This study explored how pre-service teachers integrated literacy in middle level social studies. This study was conducted in the context of the Common Core State Standards (CCSS) and their focus on disciplinary literacy, the Council for the Accreditation of Educator Preparation (CAEP) Standards and their focus on rich clinical experiences, and…

Establishing a Strong Foundation: District and School Supports for Classroom Implementation of the MDC Framework

ERIC Educational Resources Information Center

Lawrence, Nancy; Sanders, Felicia; Christman, Jolley Bruce; Duffy, Mark

2011-01-01

The Bill and Melinda Gates Foundation has invested in the development and dissemination of high-quality formative assessment tools to support teachers' incorporation of the Core Common State Standards (CCSS) into their classroom instruction. Lessons from the first generation of standards-based reforms suggest that intense attention to high quality…

The Impact of Identifying a Specific Purpose and External Audience for Writing on Second Graders' Writing Quality

ERIC Educational Resources Information Center

Block, Meghan K.

2013-01-01

The Common Core State Standards for English Language Arts and Literacy in History/Social Studies, Science, and Technical Subjects (CCSS) emphasize the importance of writing and specify that students should write for external, and, at times, unfamiliar audiences. Given the relationship between audience specification and quality writing in older…

Impact Evaluation of the National Writing Project's College-Ready Writing Project in High Poverty Rural Districts

ERIC Educational Resources Information Center

Gallagher, H. Alix; Arshan, Nicole; Woodworth, Katrina

2016-01-01

Writing is an essential skill for participating in modern American society. Although it is crucial to careers and civic engagement, student writing falls far short of national expectations (College Board, 2004; NCES, 2012; Persky, Daane, & Jin, 2003). The Common Core State Standards (CCSS) seek to increase the rigor of writing instruction…

Oakland and San Francisco Create Course Pathways through Common Core Mathematics. White Paper

ERIC Educational Resources Information Center

Daro, Phil

2014-01-01

The Common Core State Standards for Mathematics (CCSS-M) set rigorous standards for each of grades 6, 7 and 8. Strategic Education Research Partnership (SERP) has been working with two school districts, Oakland Unified School District and San Francisco Unified School District, to evaluate extant policies and practices and formulate new policies…

Mind the Comprehension Iceberg: Avoiding Titanic Mistakes with the CCSS

ERIC Educational Resources Information Center

Hollenbeck, Amy Feiker; Saternus, Kara

2013-01-01

As teachers and leaders move forward in implementing the Common Core State Standards within classrooms across 46 states, it is essential to consider the question of what knowledge is included in the English Language Arts Standards, and what knowledge is not present. The authors of the Common Core delineate an increasingly complex body of knowledge…

Framework Fuels the Need to Read: Strategies Boost Literacy of Students in Content-Area Classes

ERIC Educational Resources Information Center

Schoenbach, Ruth; Greenleaf, Cynthia L.; Hale, Gina

2010-01-01

Middle and high school teachers across academic disciplines face increased pressure to address the Common Core State Standards (CCSS) for English language arts and for literacy in history/social studies, science, and technical subjects. This means that the responsibility of preparing students to read, write, talk, and think critically about…

"Jump in Any Time": How Teacher Struggle with Curricular Reform Generates Opportunities for Teacher Learning

ERIC Educational Resources Information Center

Peercy, Megan Madigan; Martin-Beltrán, Melinda; Yazan, Bedrettin; DeStefano, Megan

2017-01-01

With the emergence of new academic demands created by curricular reforms such as the Common Core State Standards (CCSS), policy makers and educators have recognized that the linguistic complexity of new curricula requires greater coordination of instructional efforts in teaching English language learners (ELLs). However, the literature has yet to…

The Impact of Speedometry on Student Knowledge, Interest, and Emotions

ERIC Educational Resources Information Center

Polikoff, Morgan; Le, Q. Tien; Danielson, Robert W.; Sinatra, Gale M.; Marsh, Julie A.

2018-01-01

Given the dearth of high-quality curriculum materials aligned with the new standards (NGSS and CCSS) and low student persistence in STEM fields, we sought to develop and test a STEM curriculum that would improve student knowledge, interest, and emotions. A cluster randomized control trial was conducted to assess the impact of Speedometry, a…

Secondary Social Studies Teachers' Time Commitment When Addressing the Common Core State Standards

ERIC Educational Resources Information Center

Kenna, Joshua L.; Russell, William Benedict, III

2015-01-01

In 2010 the Common Core State Standards (CCSS) were officially released in America for mathematics and English language arts and soon adopted by 45 of the 50 states. However, within the English langue arts domain there were standards intended for secondary social studies teachers under the title, Common Core State Standards for English Language…

Implications of Common Core State Standards on the Social Studies

ERIC Educational Resources Information Center

Kenna, Joshua L.; Russell, William B., III.

2014-01-01

Social studies teachers have often been on the outside looking in during much of the era billed as the standards-based educational reform (SBER), but with the adoption and implementation of the Common Core State Standards (CCSS), social studies teachers seem to have been invited back inside. Yet, how will the standards impact social studies…

Development and Validation of Chemistry Self-Efficacy Scale for College Students

ERIC Educational Resources Information Center

Uzuntiryaki, Esen; Aydin, Yesim Capa

2009-01-01

This study described the process of developing and validating the College Chemistry Self-Efficacy Scale (CCSS) that can be used to assess college students' beliefs in their ability to perform essential tasks in chemistry. In the first phase, data collected from 363 college students provided evidence for the validity and reliability of the new…

Career Readiness: An Analysis of Text Complexity for Occupational Reading Materials

ERIC Educational Resources Information Center

Wei, Hua; Cromwell, Ashley Melissa; McClarty, Katie Larsen

2016-01-01

The Common Core State Standards (CCSS) and the broader college and career readiness agenda encourage educators, researchers, and other stakeholders to focus on preparing students for life after high school. A key emphasis is literacy, as the ability to read and comprehend written language is critical to success in college and careers.…

LDC and MDC Theory of Action and the Landscape of Implementation. Brief One

ERIC Educational Resources Information Center

Duffy, Mark; Park, Elizabeth

2012-01-01

To support the implementation of the Common Core State Standards (CCSS), the Bill and Melinda Gates Foundation invested in the development and dissemination of two tools aimed at operationalizing classroom instruction based on the standards: (1) the Literacy Design Collaborative (LDC)'s Framework; and (2) the Math Design Collaborative (MDC)'s…

Leading the Common Core State Standards: From Common Sense to Common Practice

ERIC Educational Resources Information Center

Dunkle, Cheryl A.

2012-01-01

Many educators agree that we already know how to foster student success, so what is keeping common sense from becoming common practice? The author provides step-by-step guidance for overcoming the barriers to adopting the Common Core State Standards (CCSS) and achieving equity and excellence for all students. As an experienced teacher and…

The Development of the easyCBM CCSS Reading Assessments: Grade 3. Technical Report #1221

ERIC Educational Resources Information Center

Alonzo, Julie; Park, Bitnara Jasmine; Tindal, Gerald

2012-01-01

In this technical report, we document the development and piloting of easyCBM reading measures aligned to the Common Core State Standards, designed for use in screening students at risk for reading difficulty and monitoring their progress as they develop reading skills. The measures, which assess students' ability to respond to…

Year 3 of Implementing the Common Core State Standards: Professional Development for Teachers and Principals

ERIC Educational Resources Information Center

Kober, Nancy; McIntosh, Shelby; Rentner, Diane Stark

2013-01-01

Timely, ongoing, and effective professional development for teachers and principals will be critical to the successful implementation of the Common Core State Standards (CCSS). These voluntary state-developed standards in mathematics and English language arts (ELA) outline the knowledge and skills that students in grades kindergarten through 12…

Examining English Language Arts Common Core State Standards Instruction through Cultural Historical Activity Theory

ERIC Educational Resources Information Center

Barrett-Tatum, Jennifer

2015-01-01

The English Language Arts Common Core State Standards and corresponding assessments brought about many changes for educators, their literacy instruction, and the literacy learning of their students. This study examined the day-to-day literacy instruction of two primary grade teachers during their first year of full CCSS implementation. Engestr?m's…

Connecting the Dots: Postsecondary's Role in Preparing K-12 Students

ERIC Educational Resources Information Center

Partnership for Assessment of Readiness for College and Careers, 2012

2012-01-01

For the first time in the nation's history 46 States and the District of Columbia have agreed that all K-12 students will be educated along a common continuum of high academic expectations known as the Common Core State Standards (CCSS). Having clear, consistent standards in English language arts/literacy and mathematics will help ensure that all…

Teachers' Understanding of and Concerns about Mathematical Modeling in the Common Core Standards

ERIC Educational Resources Information Center

Wolf, Nancy Butler

2013-01-01

Educational reform is most likely to be successful when teachers are knowledgeable about the intended reform, and when their concerns about the reform are understood and addressed. The Common Core State Standards (CCSS) is an effort to establish a set of nationwide expectations for students and teachers. This study examined teacher understanding…

The Common Core State Standards' Quantitative Text Complexity Trajectory: Figuring out How Much Complexity Is Enough

ERIC Educational Resources Information Center

Williamson, Gary L.; Fitzgerald, Jill; Stenner, A. Jackson

2013-01-01

The Common Core State Standards (CCSS) set a controversial aspirational, quantitative trajectory for text complexity exposure for readers throughout the grades, aiming for all high school graduates to be able to independently read complex college and workplace texts. However, the trajectory standard is presented without reference to how the…

Linking Literacy and Mathematics: The Support for Common Core Standards for Mathematical Practice

ERIC Educational Resources Information Center

Swanson, Mary; Parrott, Martha

2013-01-01

In a new era of Common Core State Standards (CCSS), teachers are expected to provide more rigorous, coherent, and focused curriculum at every grade level. To respond to the call for higher expectations across the curriculum and certainly within reading, writing, and mathematics, educators should work closely together to create mathematically…

RAFTing with Raptors: Connecting Science, English Language Arts, and the Common Core State Standards

ERIC Educational Resources Information Center

Senn, Gary J.; McMurtrie, Deborah H.; Coleman, Bridget K.

2013-01-01

This article explores using the RAFT strategy (Role, Audience, Format, Topic) for writing in science classes. The framework of the RAFT strategy will be explained, and connections with Common Core State Standards (CCSS) for ELA/Literacy will be discussed. Finally, there will be a discussion of a professional learning experience for teachers in…

Examining Elementary Literacy Teachers' Perceptions of Their Preparedness to Implement the English Language Arts Common Core State Standards

ERIC Educational Resources Information Center

Adams-Budde, Melissa; Miller, Samuel

2015-01-01

The purpose of our study was to examine elementary literacy teachers' perceptions of their preparedness to implement the ELA CCSS [English Language Arts Common Core State Standards]. We defined preparedness across three dimensions: teachers' perceived levels of knowledge of the standards and its components; efficacy to implement changes; and…

The Common Core State Standards: An Opportunity to Enhance Formative Assessment in History/Social Studies Classrooms

ERIC Educational Resources Information Center

Ateh, Comfort M.; Wyngowski, Aaron J.

2015-01-01

This article discusses the opportunity that the Common Core State Standards (CCSS) present for enhancing formative assessment (FA) in history and social studies classrooms. There is evidence that FA can enhance learning for students if implemented well. Unfortunately, teachers continue to be challenged in implementing FA in their classrooms. We…

Carpe Diem: Seizing the Common Core with Visual Thinking Strategies in the Visual Arts Classroom

ERIC Educational Resources Information Center

Franco, Mary; Unrath, Kathleen

2014-01-01

This article demonstrates how Visual Thinking Strategies (VTS) art discussions and subsequent, inspired artmaking can help reach the goals of the Common Core State Standards for English Language Arts & Literacy in History/Social Studies, Science, & Technical Subjects (CCSS-ELA). The authors describe how this was achieved in a remedial…

Common Core State Standards: A Tool for Improving Education. NEA Policy Brief

ERIC Educational Resources Information Center

National Education Association, 2010

2010-01-01

For many years, there have been efforts to promote the development of national standards for education in the United States. In the Spring of 2010, the National Governors Association (NGA) and the Council of Chief State School Officers (CCSSO) completed a project to develop Common Core State Standards (CCSS). Leading education organizations, such…

Success with ELLs: Working with English Language Learners--Looking Back, Moving Forward

ERIC Educational Resources Information Center

DelliCarpini, Margo; Alonso, Orlando

2013-01-01

In the years since 2008, when the "Success with ELLs" column started, these authors have seen many changes to the educational landscape, not dealing specifically with ELLs, but having implications for their education. Probably, the most significant change has been the adoption of the Common Core State Standards (CCSS), which have no…

States' Description of Common Core State Standards to Support Students with Severe Disabilities

ERIC Educational Resources Information Center

Dukes, Charles; Darling, Sharon M.; Bielskus-Barone, Kristina

2017-01-01

A review of State Department of Education and school district websites was conducted to determine how policy related to the Common Core State Standards (CCSS) was communicated to teachers of students with severe disabilities. Four states were selected: California, New York, Illinois, and Pennsylvania. State Department of Education websites and…

Transitioning to the Common Core State Standards for Mathematics: A Mixed Methods Study of Elementary Teachers' Experiences and Perspectives

ERIC Educational Resources Information Center

Swars, Susan Lee; Chestnutt, Cliff

2016-01-01

This mixed methods study explored elementary teachers' (n = 73) experiences with and perspectives on the recently implemented Common Core State Standards for Mathematics (CCSS-Mathematics) at a high-needs, urban school. Analysis of the survey, questionnaire, and interview data reveals the findings cluster around: familiarity with and preparation…

Leading Change: Transitioning to the Common Core

ERIC Educational Resources Information Center

Brandt, Brian

2012-01-01

For many school districts in the United States, making the transition to the Common Core State Standards (CCSS) is proving to be a challenge at a time when they are already facing many obstacles, not the least of which is dwindling financial resources. A change of this magnitude cannot be made haphazardly; to be successful in its goal of helping…

Common Core Math in the K-8 Classroom: Results from a National Teacher Survey

ERIC Educational Resources Information Center

Bay-Williams, Jennifer

2016-01-01

Successful implementation of the Common Core State Standards for Mathematics (CCSS-M) should result in noticeable differences in primary and middle school math classrooms across the United States. "Common Core Math in the K-8 Classroom: Results from a National Teacher Survey" takes a close look at how educators are implementing the…

Toolkit for Evaluating Alignment of Instructional and Assessment Materials to the Common Core State Standards

ERIC Educational Resources Information Center

Achieve, Inc., 2014

2014-01-01

In joint partnership, Achieve, The Council of Chief State School Officers, and Student Achievement Partners have developed a Toolkit for Evaluating the Alignment of Instructional and Assessment Materials to the Common Core State Standards. The Toolkit is a set of interrelated, freely available instruments for evaluating alignment to the CCSS; each…

Principled Neglect and Compliance: Responses to NCLB and the CCSS at an Expeditionary Learning Middle School

ERIC Educational Resources Information Center

Stern, Rebecca

2016-01-01

This qualitative study explored educators' sense making of and responses to No Child Left Behind and the Common Core State Standards at one urban Expeditionary Learning middle school. Sense-making theory (Spillane, Reiser, & Reimer, 2002) and inquiry as stance (Cochran-Smith & Lytle, 2009) were used as complementary conceptual frameworks…

Impacts of Professional Development on High School Mathematics Teachers as They Implement Common Core State Standards

ERIC Educational Resources Information Center

Saucedo, Ana A.

2017-01-01

The purpose of this qualitative study was to understand the perceptions of high school mathematics teachers regarding the support provided through professional development (PD) as they engage in the implementation of the Common Core State Standards (CCSS). By means of a qualitative instrumental case study, eight high school mathematics teachers…

An Interpretative Phenomenological Analysis of the Common Core Standards Program in the State of South Dakota

ERIC Educational Resources Information Center

Alase, Abayomi

2017-01-01

This interpretative phenomenological analysis (IPA) study investigated and interpreted the Common Core State Standards program (the phenomenon) that has been the dominating topic of discussions amongst educators all across the country since the inauguration of the program in 2014/2015 school session. Common Core State Standards (CCSS) was a…

English Learners, Writing, and the Common Core

ERIC Educational Resources Information Center

Olson, Carol Booth; Scarcella, Robin; Matuchniak, Tina

2015-01-01

Adopted by 46 states, the Common Core State Standards (CCSS) present a vision of what it means to be literate in the twenty-first century and call for all students, including English learners, to develop critical reading skills necessary for a deep understanding of complex texts, and critical writing skills to write about those texts. This article…

Connecting Science and Math Concepts with Children's and Young Adult Literature in a CCSS World

ERIC Educational Resources Information Center

Jewett, Pamela; Johnson, Denise; Lowery, Ruth McKoy; Stiles, James W.

2015-01-01

In this article, the authors provide a synopsis of the 2014 Children's Literature Assembly (CLA) Workshop. The Workshop explored how fiction and nonfiction children's and young adult's literature create opportunities for in-depth learning in the content areas. Participants had the opportunity to hear the stories of authors and illustrators of…

A Case Study of Common Core Implementation in a Linked Learning Environment

ERIC Educational Resources Information Center

Biolchino, Erin Broun

2016-01-01

California is in the midst of significant educational reform initiatives, especially at the secondary level. The Common Core State Standards (CCSS) were adopted in 2010, and these new standards contain significant changes in the areas of math, English, and literacy across all subjects. Many districts are also implementing new initiatives to engage…

State Standard-Setting Processes in Brief. State Academic Standards: Standard-Setting Processes

ERIC Educational Resources Information Center

Thomsen, Jennifer

2014-01-01

Concerns about academic standards, whether created by states from scratch or adopted by states under the Common Core State Standards (CCSS) banner, have drawn widespread media attention and are at the top of many state policymakers' priority lists. Recently, a number of legislatures have required additional steps, such as waiting periods for…

Predictors of inactive lifestyle among adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

PubMed

Ness, Kirsten K; Leisenring, Wendy M; Huang, Sujuan; Hudson, Melissa M; Gurney, James G; Whelan, Kimberly; Hobbie, Wendy L; Armstrong, Gregory T; Robison, Leslie L; Oeffinger, Kevin C

2009-05-01

: Participation in physical activity is important for childhood cancer survivors, because inactivity may compound cancer/treatment-related late effects. However, some survivors may have difficulty participating in physical activity, and these individuals need to be identified so that risk-based guidelines for physical activity, tailored to specific needs, can be developed and implemented. The objectives of the current study were to document physical activity patterns in the Childhood Cancer Survivor Study (CCSS) cohort, to compare the physical activity patterns with siblings in the CCSS and with a population-based sample from the Behavioral Risk Factor Surveillance System, and to evaluate associations between diagnosis, treatment, and personal factors in terms of the risk for an inactive lifestyle. : Percentages of participation in recommended physical activity were compared among survivors, siblings, and population norms. Generalized linear models were used to evaluate the associations between cancer diagnosis and therapy, sociodemographics, and the risk for an inactive lifestyle. : Participants included 9301 adult survivors of childhood cancer and 2886 siblings. Survivors were less likely than siblings (46% vs 52%) to meet physical activity guidelines and were more likely than siblings to report an inactive lifestyle (23% vs 14%). Medulloblastoma (35%) and osteosarcoma (27%) survivors reported the highest levels of inactive lifestyle. Treatments with cranial radiation or amputation were associated with an inactive lifestyle as were being a woman, black race, older age, lower educational attainment, underweight or obese status, smoking, and depression. : Childhood cancer survivors were less active than a sibling comparison group or an age- and sex-matched population sample. Survivors who are at risk for an inactive lifestyle should be considered high priority for developing and testing of intervention approaches. Cancer 2009. (c) 2009 American Cancer Society.

K-5 Literacy Education: A Comparison between American Common Core State Standards and Chinese National Curriculum Standards

ERIC Educational Resources Information Center

Zhang, Haiyan; Yin, Jianjun

2014-01-01

Literacy education is the most important part in school education and its efficiency determines the students' achievements in their future education and career. In 2010, the Common Core State Standards (CCSS) were released, which aimed to provide common standards for K-12 public school students in the whole country to improve the educational…

A Path to Alignment: Connecting K-12 and Higher Education via the Common Core and the Degree Qualifications Profile

ERIC Educational Resources Information Center

Conley, David T.; Gaston, Paul L.

2013-01-01

The Common Core State Standards (CCSS), which aim to assure competency in English/language arts and mathematics through the K-12 curriculum, define necessary but not sufficient preparedness for success in college. The Degree Qualifications Profile (DQP), which describes what a college degree should signify, regardless of major, offers useful but…

Young Meaning Makers--Teaching Comprehension, Grades K-2. Common Core State Standards in Literacy Series

ERIC Educational Resources Information Center

Reutzel, D. Ray; Clark, Sarah K.; Jones, Cindy D.; Gillam, Sandra L.

2016-01-01

One of the most critical elements in the Common Core State Standards (CCSS) is the effective teaching of reading comprehension in the early years. This timely resource provides evidence-based practices for teachers to use as they work to meet standards associated with comprehending complex literature and informational texts. The authors offer a…

Idaho Adopted Higher Standards to Prepare All Students for College and Careers

ERIC Educational Resources Information Center

Willits, Luci

2014-01-01

Two years ago the state officially chose to adopt the Common Core State Standards (CCSS) as Idaho's new Core Standards in mathematics and English language arts. For Idaho's students these standards are not only higher but also comparable with those in any other country in the world. These new standards will bring significant changes for Idaho…

Questioning Reform in the Standards Movement: Professional Development and Implementation of Common Core across the Rural South

ERIC Educational Resources Information Center

Barrett-Tatum, Jennifer; Smith, Jason M.

2018-01-01

The Common Core State Standards (CCSS) were adopted in an effort to create a consistent set of standards across schools, districts, and states in order to ensure equality of educational opportunities for all students in the country. Educational reform through standardization implies that across thousands of miles and millions of students,…

A Research Agenda for the Common Core State Standards: What Information Do Policymakers Need?

ERIC Educational Resources Information Center

Rentner, Diane Stark; Ferguson, Maria

2014-01-01

This report looks specifically at the information and data needs of policymakers related to the Common Core State Standards (CCSS) and the types of research that could provide this information. The ideas in this report were informed by a series of meetings and discussions about a possible research agenda for the Common Core, sponsored by the…

Elish-Piper: Response to "Beyond the Common Core: Examining 20 Years of Literacy Priorities and Their Impact on Struggling Readers"

ERIC Educational Resources Information Center

Elish-Piper, Laurie

2016-01-01

As Cassidy et al. (2016) outline in their article, the Common Core State Standards (CCSS; National Governors Association [NGA] Center for Best Practices & Council of Chief State School Officers [CCSSO], 2010) have taken center stage in education, pushing other important topics and issues aside as teachers scramble to transform their teaching…

Building Content Knowledge in Elementary English Language Arts: How a Shift in Curriculum Affects Teacher Perception of Reading

ERIC Educational Resources Information Center

Ellis, Raquel

2017-01-01

Desert Elementary is a suburban Phoenix K-5 school. The school has undergone a significant change in its approach to reading instruction due to the Common Core State Standards (CCSS) instructional shift of building knowledge through content rich nonfiction. Teachers implemented this shift in their classrooms through a 16-month professional…

Informational Writing in High School Science: The Importance of Genre, Apprenticeship, and Publication

ERIC Educational Resources Information Center

Kohnen, Angela M.

2013-01-01

As states continue to implement CCSS, science teachers will be asked to incorporate more discipline-specific reading and writing in their classes. Yet, according to national studies, few science teachers have previous experience to draw upon and most have little to no training in writing pedagogy. This article reports on one science teacher's…

Examining Perceptions over the Effectiveness of Professional Development and Available Resources on the Common Core State Standards Implementation in Arkansas

ERIC Educational Resources Information Center

Sheppard, Julie Trammell

2013-01-01

The purpose of this qualitative case study is to examine the perceptions of teachers and curriculum specialists over the effectiveness of professional development and available resources of the Common Core State Standards (CCSS) implementation process in Arkansas. Arkansas divided the implementation process into three stages: Phase I implemented…

Growing Awareness, Growing Support: Teacher and Voter Understanding of the Common Core State Standards & Assessments

ERIC Educational Resources Information Center

Achieve, Inc., 2012

2012-01-01

Since June 2010, 46 states and Washington DC have chosen to adopt the Common Core State Standards (CCSS)--K-12 standards in mathematics and English language arts/literacy developed through a multi-state initiative led by the National Governors Association and the Council of Chief State School Officers. As implementation of the standards is…

The Power of Questions to Bring Balance to the Curriculum in the Age of New Standards

ERIC Educational Resources Information Center

del Prado, Pixita; McMillen, Susan E.; Friedland, Ellen S.

2017-01-01

The Common Core State Standards (CCSS); the Next Generation Science Standards (NGSS); and the College, Career, and Civic Life (C3) Framework for Social State Standards are bringing many changes to schools and classrooms across the United States. This article suggests using the power of questions to make connections across seemingly disparate…

Modelling and Bibliotherapy as Tools to Enhance Pro-Social Interactions during English Language Arts Lessons with First Graders

ERIC Educational Resources Information Center

Nguyen, Neal; Lyons, Catherine; Gelfer, Jeff; Leytham, Patrick; Nelson, Leslie; Krasch, Delilah; O'Hara, Katie

2016-01-01

Play is one of the essential components in proper development of first-grade students. Since the adoption by various states of the Common Core State Standards (CCSS), two outcomes have developed: (a) increased instructional time and (b) decreased public school recess periods across school districts. Given the complex nature of daily instructional…

Enacting Common Core Instruction: How School District Leadership Drove Implementation of LDC and MDC in Kenton County, KY

ERIC Educational Resources Information Center

Research For Action, 2012

2012-01-01

Funded by The Bill & Melinda Gates Foundation, the Literacy Design Collaborative (LDC) and Math Design Collaborative (MDC) offer a set of instructional and formative assessment tools in literacy and math, which were developed to help educators better prepare all students to meet the Common Core State Standards (CCSS) and succeed beyond high…

Learning to Love the Questions: How Essential Questions Promote Creativity and Deep Learning

ERIC Educational Resources Information Center

Wilhelm, Jeffrey D.

2014-01-01

Educators know that creativity and innovation involve questioning and the capacity to frame topics as problems to be solved. They know that we are living in a time of a new generation of standards, including the Common Core State Standards (CCSS). In the U.S., compliance with these standards requires that educators encourage students to ask…

Establishing a Strong Foundation: District and School-Level Supports for Classroom Implementation of the LDC and MDC Frameworks. Executive Summary

ERIC Educational Resources Information Center

Reumann-Moore, Rebecca; Lawrence, Nancy; Sanders, Felicia; Christman, Jolley Bruce; Duffy, Mark

2011-01-01

The Bill and Melinda Gates Foundation has invested in the development and dissemination of high-quality instructional and formative assessment tools to support teachers' incorporation of the Core Common State Standards (CCSS) into their classroom instruction. Literacy experts have developed a framework and a set of templates that teachers can use…

Informational Text and the Common Core: A Content Analysis of Three Basal Reading Programs

ERIC Educational Resources Information Center

Walters, Barbara A.

2013-01-01

The Common Core State Standards for English Language Arts (CCSS-ELA) will have a significant impact on what teachers teach and what primary students are supposed to be able to do (Bomer & Maloch, 2011). By the end of fourth grade, reading instruction should be evenly balanced between literary text and informational text (NGA Center and CCSSO,…

"Better to Be a Pessimist": A Narrative Inquiry into Mathematics Teachers' Experience of the Transition to the Common Core

ERIC Educational Resources Information Center

Martinie, Sherri L.; Kim, Jeong-Hee; Abernathy, Deborah

2016-01-01

The Common Core State Standards (CCSS) are a focus of state education policy today influencing curriculum implementation and assessment in public schools. The purpose of this narrative inquiry is to understand how high school mathematics teachers experience the transition period. Based on interviews with mathematics teachers in a high school in…

Leveraging the Common Core to Support College and Career Readiness in California

ERIC Educational Resources Information Center

Venezia, Andrea; Lewis, Jodi

2015-01-01

The early years of the implementation of the Common Core State Standards (CCSS) in California were complicated by the Great Recession as well as by a significant devolution of finance and programmatic control to the local level through the Local Control Funding Formula. The state charted a steady course and took a systematic approach to CCSS…

Forging Ahead! Teachers Reflect on the Early Adopter Program to Implement the Common Core State Standards

ERIC Educational Resources Information Center

Koning, Erin; Houghtby, Beth; Izard, Patrice; Schuler, Jennifer

2014-01-01

This "water cooler" column features e-mail conversations between Erin Koning and three teachers--Beth, Jenna, and Patrice--and is a reflection of their participation in a Chicago Public School (CPS), professional development series designed to support the implementation of the Common Core State Standards (CCSS) in grades K-12. At the…

Getting a Grip on Librarian Evaluation

ERIC Educational Resources Information Center

Jaeger, Paige

2013-01-01

When the Common Core State Standards (CCSS) were adopted in many states, it was only one piece of the pie called Race to the Top (RttT). As states competed and clamored to win the Race to the Top dollars, they knew it came with strings attached. The biggest piece of string is called APPR, or Annual Professional Performance Review--and it is more…

Testing under the Microscope: How Common Core-Aligned Assessments Place Demands on Time, Technology, and Connectivity

ERIC Educational Resources Information Center

Stephens, Wendy

2014-01-01

School librarians and other specialists should take note of the new wave of computer-based assessments required by the Common Core State Standards (CCSS), testing that is only now beginning to get off the ground. The new testing necessitates that districts possess the right hardware, install the requisite software, and, in some cases, create…

The CORE Community: Career and Technical Education Teachers' Perceptions of the Common Core State Standards after a Professional Development Training

ERIC Educational Resources Information Center

Stair, Kristin; Hock, Gaea; Warner, Wendy; Levy, Natalie; Conrad, Michelle

2017-01-01

Since the 1983 U.S Department of Education's report, "A Nation at Risk," various educational initiatives have been developed to support an increase in state standards and greater educational accountability (Liebtag, 2013). Despite opportunities to link Common Core State Standards (CCSS) and instructional curriculum, CTE teachers often…

High Stakes Testing in the 21st Century: Implications for Students in Special Education

ERIC Educational Resources Information Center

Gordon, Lola

2016-01-01

High-stakes testing has been a part of American education since its inception. The laws that govern the use of high-stakes tests include language that mandates the inclusion of students in special education. These laws play an influential role in the new large-scale assessments aligned with the Common Core State Standards (CCSS). The assessments…

Putting a Price Tag on the Common Core: How Much Will Smart Implementation Cost?

ERIC Educational Resources Information Center

Murphy, Patrick; Regenstein, Elliot

2012-01-01

The Common Core State Standards (CCSS) for English language arts and mathematics represent a sea change in standards-based reform and their implementation is the movement's next--and greatest--challenge. Yet, while most states have now set forth implementation plans, these tomes seldom address the crucial matter of cost. Putting a Price Tag on the…

Utilizing Discourse in the Development of Strategic Readers in the Content Areas

ERIC Educational Resources Information Center

Spies, Tracy G.

2016-01-01

The impetus behind the design and implementation of the Common Core State Standards (CCSS) was to establish nationwide criteria in preparing students to be college or career ready by the end of high school. The standards require students to comprehend, analyze, and evaluate text across a wide range of disciplines. Essential to the mastery of the…

Secondary Science Teachers' Implementation of CCSS and NGSS Literacy Practices: A Survey Study

ERIC Educational Resources Information Center

Drew, Sally Valentino; Thomas, Jeffrey

2018-01-01

Most middle and high school students struggle with reading and writing in science. This may be because science teachers are reluctant to teach literacy in science class. New standards now require a shift in the way science teachers develop students' literacy in science. This survey study examined the extent to which science teachers report…

Comparing the Common Core State Standards in Mathematics and NCTM's "Curriculum Focal Points". Achieving the Common Core

ERIC Educational Resources Information Center

Achieve, Inc., 2010

2010-01-01

Through the Common Core State Standards (CCSS) Initiative, states and territories have collaborated in the development of a common core of standards in English Language Arts and mathematics for grades kindergarten through twelve that are now being adopted by states. Designed not only for the purpose of providing strong, shared expectations, the…

The Poetry of Dandelions: Merging Content-Area Literacy and Science Content Knowledge in a Fourth-Grade Science Classroom

ERIC Educational Resources Information Center

Madden, Lauren; Peel, Anne; Watson, Heather

2014-01-01

As teachers begin to implement the Common Core State Standards (CCSS) and Next Generation Science Standards (NGSS), they are challenged to focus on informational texts across the disciplines and engage children in critical thinking about complex scientific ideas. In this article, we present an integrated science-language arts lesson that explores…

21st Century Standards and Curriculum: Current Research and Practice

ERIC Educational Resources Information Center

Alismail, Halah Ahmed; McGuire, Patrick

2015-01-01

The integration of Common Core State Standards (CCSS) and 21st century skills in the curriculum is not only beneficial to students and teachers, but also necessary to prepare our youth for their future careers. In an age of education where standardized tests determine the success of our schools, it is important to allow students the creativity and…

Managing Reform Efforts in Times of Uncertainty: Effects of Principal Support and Leadership on Teachers' Implementation Commitment to Common Core Reform Initiatives

ERIC Educational Resources Information Center

Smith, Lee W.

2016-01-01

The Common Core State Standards (CCSS) require a major shift in instructional practices among teachers. Such changes cause much uncertainty as teachers' roles and identities begin to change. Major school reform creates difficulty for school leaders who must develop teacher support and dedication to 'top-down' reform initiatives in their…

Integrating Content and Literacy in Social Studies: Assessing Instructional Materials and Student Work from a Common Core-Aligned Intervention

ERIC Educational Resources Information Center

Reisman, Abby

2017-01-01

The Common Core State Standards (CCSS) call on science and social studies teachers to engage in literacy instruction that prepares students for the academic rigors of college. The Literacy Design Collaborative (LDC) designed a framework to address the challenge of literacy-content integration. At the heart of the intervention are fill-in-the-blank…

The Common Core State Standards and the Elementary Social Studies Curriculum: A Case Study of Teacher Perceptions in Florida

ERIC Educational Resources Information Center

Nadeau, Kacie M.

2017-01-01

The most recent phase of curriculum reform in the era of accountability is the Common Core State Standards (CCSS) which have essentially reshaped the landscape of public education. Its objective of preparing K-12 students for college and career upon high school graduation have prioritized English language arts, mathematics, and science over social…

Reading Don't Fix No Chevys (Yet!): Motivating Boys in the Age of the Common Core

ERIC Educational Resources Information Center

Wilhelm, Jeffrey D.; Smith, Michael W.

2015-01-01

Research establishes that boys underperform in literacy relative to girls. If boys are to be successful on the assessments designed to measure achievement on the Common Core State Standards (CCSS) and if they are to become lifelong readers, they must be motivated to embrace instruction designed both to prepare them for success and to experience…

Protocol for the Assessment of Common Core Teaching: The Impact of Instructional Inclusion on Students with Special Needs

ERIC Educational Resources Information Center

Gallagher, Kathleen L.; Odozi, Anthony

2015-01-01

The quality of instruction in the classroom is the most powerful leverage point for school improvement because it is the only thing over which educators have a significant degree of control. As student assessments change to reflect the higher expectations of Common Core State Standards (CCSS), it is important that the assessment and development of…

Burying the Hatchet: Ideology in Early American Readers through the Story of George Washington and the Cherry Tree

ERIC Educational Resources Information Center

David, Ann

2016-01-01

This article examines the story of Washington chopping down the cherry tree, as it appears in school readers. The author discusses the ideological influences that guided authors in molding and shifting the story through the decades. At the end, the author returns to the Common Core State Standards (CCSS) revival of Washington, which demonstrates…

Competitive Debate as Competency-Based Learning: Civic Engagement and Next-Generation Assessment in the Era of the Common Core Learning Standards

ERIC Educational Resources Information Center

McIntosh, Jonathan; Milam, Myra

2016-01-01

As the adoption and execution of the Common Core State Standards (CCSS) have steadily increased, the debate community is presented with an opportunity to be more forward thinking and sustainable through the translation to curriculum planning and next-generation assessment as a movement towards Performance-Based Assessments. This paper focuses on…

Assessing Impacts of "Math in Focus," a "Singapore Math" Program for American Schools

ERIC Educational Resources Information Center

Jaciw, Andrew P.; Hegseth, Whitney; Toby, Megan

2015-01-01

The Common Core State Standards (CCSS) have been developed in response to the criticism that students in the U.S. are graduating from high school without being college and career ready and that they are falling behind their counterparts in other countries in key subject areas. In this work, the authors report the results of an efficacy study that…

State Capacity for Leadership: Ensuring Meaningful Higher Education Involvement in State Implementation of New Assessments Aligned with the Common Core State Standards

ERIC Educational Resources Information Center

National Center for Higher Education Management Systems (NJ1), 2011

2011-01-01

The Common Core State Standards (CCSS) and assessments aligned to them represent a significant milestone in public education reform in the U.S. Developed with consultation from higher education, the rigorous new standards and the assessments now being drafted by two consortia promise to help students reach higher levels of academic achievement and…

Opening the Common Core: How to Bring ALL Students to College and Career Readiness

ERIC Educational Resources Information Center

Burris, Carol Corbett; Garrity, Delia T.

2012-01-01

Do you wish you could leverage the Common Core State Standards (CCSS) to equip all students--not just high achievers--with the higher-level thinking skills they need? You can, and this book will show you how. The authors helped lead their district--Rockville Centre in Long Island, New York--in closing achievement gaps and increasing the number of…

Inclusion versus Specialized Intervention for Very-Low- Performing Students: What Does Access Mean in an Era of Academic Challenge?

ERIC Educational Resources Information Center

Fuchs, Lynn S.; Fuchs, Douglas; Compton, Donald L.; Wehby, Joseph; Schumacher, Robin F.; Gersten, Russell; Jordan, Nancy C.

2015-01-01

The purpose of this analysis was to examine achievement gaps on fractions for very-low-performing students as a function of whether they receive inclusive fraction instruction or specialized fraction intervention and with the shift to Common Core State Standards (CCSS). In three randomized control trials conducted in 3 consecutive years, 203…

Inclusion versus Specialized Intervention for Very-Low-Performing Students: What Does "Access" Mean in an Era of Academic Challenge?

ERIC Educational Resources Information Center

Fuchs, Lynn S.; Fuchs, Douglas; Compton, Donald L.; Wehby, Joseph; Schumacher, Robin F.; Gersten, Russell; Jordan, Nancy C.

2015-01-01

The purpose of this analysis was to examine achievement gaps on fractions for very-low-performing students as a function of whether they receive inclusive fraction instruction or specialized fraction intervention and with the shift to Common Core State Standards (CCSS). In three randomized control trials conducted in 3 consecutive years, 203…

A Quantitative Content Analysis of the Common Core State Standards Compared to Missouri's Grade-Level Expectations Using the Revised Bloom's Taxonomy Framework

ERIC Educational Resources Information Center

Gallia, Toni

2012-01-01

With the pressure in education to develop a 21st century learner with higher-level thinking skills, many educators connected previous state curriculum to the Common Core State Standards (CCSS). Missouri's Department of Education experts paired the previous state's curriculum known as the Missouri Grade Level Expectations (MO GLEs) with a…

Year 3 of Implementing the Common Core State Standards: An Overview of States' Progress and Challenges

ERIC Educational Resources Information Center

Rentner, Diane Stark

2013-01-01

States are in a crucial phase of implementing the Common Core State Standards (CCSS), which outline the knowledge and skills that students in grades kindergarten through 12 are expected to learn in mathematics and English language arts (ELA) to be prepared for college and careers. As of July 2013, 45 states and the District of Columbia have…

The Common Core State Standards and Early Language Learning: Let's Do This!

ERIC Educational Resources Information Center

Haxhi, Jessica

2014-01-01

The Common Core State Standards (CCSS) are here to stay--for awhile at least--and students will be tested on their ability to meet these standards. In order for students to succeed--in order for them to be College and Career Ready--they will need the support of educators working together to give them practice in meeting these standards. World…

Common Core and the Uncommon Learner: How Autism Affects Acquisition of Common Core State Standards

ERIC Educational Resources Information Center

Marsh, Wendela Whitcomb

2015-01-01

The Common Core State Standards (CCSS 2014a, b) are here to stay. State and local education agencies are responsible for ensuring that schools teach all students the core standards that they will need in college and the work force. However, the ever-growing population of students on the autism spectrum has unique learning needs which may make it…

Enacting Common Core Instruction: How Intermediate Unit 13 Leveraged Its Position as an Educational Service Agency to Implement and Scale the LDC Initiative

ERIC Educational Resources Information Center

Research For Action, 2014

2014-01-01

Funded by The Bill & Melinda Gates Foundation, the Literacy Design Collaborative (LDC) and Math Design Collaborative (MDC) offer a set of instructional and formative assessment tools in literacy and math, which were developed to help educators better prepare all students to meet the Common Core State Standards (CCSS) and succeed beyond high…

Willing but Not Yet Ready: A Glimpse of California Teachers' Preparedness for the Common Core State Standards. CenterView

ERIC Educational Resources Information Center

Center for the Future of Teaching and Learning at WestEd, 2012

2012-01-01

California is on the precipice of implementing the Common Core State Standards (CCSS), which were developed through an initiative of the National Governors Association and the Council of Chief State School Officers to reflect the knowledge and skills needed for success in college and careers. In California, one of 45 adopting states, the standards…

The Implementation and Effects of the Literacy Design Collaborative (LDC): Early Findings in Sixth-Grade Advanced Reading Courses. CRESST Report 846

ERIC Educational Resources Information Center

Herman, Joan L.; Epstein, Scott; Leon, Seth; Dai, Yunyun; La Torre Matrundola, Deborah; Reber, Sarah; Choi, Kilchan

2015-01-01

The Bill and Melinda Gates Foundation invested in the Literacy Design Collaborative (LDC) as one strategy to support teachers' and students' transition to the Common Core State Standards (CCSS) in English language arts. This report provides an early look at the implementation of LDC in sixth-grade Advanced Reading classes in a large Florida…

Common Core in the Districts: An Early Look at Early Implementers

ERIC Educational Resources Information Center

Cristol, Katie; Ramsey, Brinton S.

2014-01-01

The last year has found critics and advocates of the Common Core State Standards (CCSS) duking it out in the political arena. The Thomas B. Fordham Institute, an ardent supporter of high standards for some seventeen years, has recently lurched out of the safe haven of think tankery and into the boxing ring. Yet wherever one stands on the merits of…

Year 3 of Implementing the Common Core State Standards: Transitioning to CCSS-Aligned Curriculum and Assessments for Students with Disabilities

ERIC Educational Resources Information Center

Frizzell, Matthew

2013-01-01

This report, based on a spring 2013 survey of state education agency officials in Common Core-adopting states, focuses on state efforts to prepare students with disabilities for the Common Core State Standards. The report also addresses the challenges states face with supporting teachers of students with disabilities and state plans for assessing…

States and the (Not So) New Standards--Where Are They Now? State Academic Standards: Activity around the Common Core

ERIC Educational Resources Information Center

Salazar, Tonette; Christie, Kathy

2014-01-01

States began adopting the Common Core State Standards (CCSS) in 2010 after they were launched by the Council of Chief State School Officers and the National Governors Association. Five years later, policymakers in numerous states continue to debate the Common Core and related elements, such as how to assess the standards. This brief provides a…

Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: a report from the childhood cancer survivor study.

PubMed

Nathan, Paul Craig; Ness, Kirsten Kimberlie; Mahoney, Martin Christopher; Li, Zhenghong; Hudson, Melissa Maria; Ford, Jennifer Sylene; Landier, Wendy; Stovall, Marilyn; Armstrong, Gregory Thomas; Henderson, Tara Olive; Robison, Leslie L; Oeffinger, Kevin Charles

2010-10-05

Survivors of childhood cancer may develop a second malignant neoplasm during adulthood and therefore require regular surveillance. To examine adherence to population cancer screening guidelines by survivors at average risk for a second malignant neoplasm and adherence to cancer surveillance guidelines by survivors at high risk for a second malignant neoplasm. Retrospective cohort study. The Childhood Cancer Survivor Study (CCSS), a 26-center study of long-term survivors of childhood cancer that was diagnosed between 1970 and 1986. 4329 male and 4018 female survivors of childhood cancer who completed a CCSS questionnaire assessing screening and surveillance for new cases of cancer. Patient-reported receipt and timing of mammography, Papanicolaou smear, colonoscopy, or skin examination was categorized as adherent to the U.S. Preventive Services Task Force guidelines for survivors at average risk for breast or cervical cancer or the Children's Oncology Group guidelines for survivors at high risk for breast, colorectal, or skin cancer as a result of cancer therapy. In average-risk female survivors, 2743 of 3392 (80.9%) reported having a Papanicolaou smear within the recommended period, and 140 of 209 (67.0%) reported mammography within the recommended period. In high-risk survivors, rates of recommended mammography among women were only 241 of 522 (46.2%) and the rates of colonoscopy and complete skin examinations among both sexes were 91 of 794 (11.5%) and 1290 of 4850 (26.6%), respectively. Data were self-reported. Participants in the CCSS are a selected group of survivors, and their adherence may not be representative of all survivors of childhood cancer. Female survivors at average risk for a second malignant neoplasm show reasonable rates of screening for cervical and breast cancer. However, surveillance for new cases of cancer is very low in survivors at the highest risk for colon, breast, or skin cancer, suggesting that survivors and their physicians need education about their risks and recommended surveillance. The National Cancer Institute, National Institutes of Health, and the American Lebanese Syrian Associated Charities.

The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: A systematic review and meta-analysis of randomized and non-randomized studies – The Cardiac Rehabilitation Outcome Study (CROS)

PubMed Central

Davos, Constantinos H; Doherty, Patrick; Saure, Daniel; Metzendorf, Maria-Inti; Salzwedel, Annett; Völler, Heinz; Jensen, Katrin; Schmid, Jean-Paul

2016-01-01

Background The prognostic effect of multi-component cardiac rehabilitation (CR) in the modern era of statins and acute revascularisation remains controversial. Focusing on actual clinical practice, the aim was to evaluate the effect of CR on total mortality and other clinical endpoints after an acute coronary event. Design Structured review and meta-analysis. Methods Randomised controlled trials (RCTs), retrospective controlled cohort studies (rCCSs) and prospective controlled cohort studies (pCCSs) evaluating patients after acute coronary syndrome (ACS), coronary artery bypass grafting (CABG) or mixed populations with coronary artery disease (CAD) were included, provided the index event was in 1995 or later. Results Out of n = 18,534 abstracts, 25 studies were identified for final evaluation (RCT: n = 1; pCCS: n = 7; rCCS: n = 17), including n = 219,702 patients (after ACS: n = 46,338; after CABG: n = 14,583; mixed populations: n = 158,781; mean follow-up: 40 months). Heterogeneity in design, biometrical assessment of results and potential confounders was evident. CCSs evaluating ACS patients showed a significantly reduced mortality for CR participants (pCCS: hazard ratio (HR) 0.37, 95% confidence interval (CI) 0.20–0.69; rCCS: HR 0.64, 95% CI 0.49–0.84; odds ratio 0.20, 95% CI 0.08–0.48), but the single RCT fulfilling Cardiac Rehabilitation Outcome Study (CROS) inclusion criteria showed neutral results. CR participation was also associated with reduced mortality after CABG (rCCS: HR 0.62, 95% CI 0.54–0.70) and in mixed CAD populations. Conclusions CR participation after ACS and CABG is associated with reduced mortality even in the modern era of CAD treatment. However, the heterogeneity of study designs and CR programmes highlights the need for defining internationally accepted standards in CR delivery and scientific evaluation. PMID:27777324

Efficient cooperative compressive spectrum sensing by identifying multi-candidate and exploiting deterministic matrix

NASA Astrophysics Data System (ADS)

Li, Jia; Wang, Qiang; Yan, Wenjie; Shen, Yi

2015-12-01

Cooperative spectrum sensing exploits the spatial diversity to improve the detection of occupied channels in cognitive radio networks (CRNs). Cooperative compressive spectrum sensing (CCSS) utilizing the sparsity of channel occupancy further improves the efficiency by reducing the number of reports without degrading detection performance. In this paper, we firstly and mainly propose the referred multi-candidate orthogonal matrix matching pursuit (MOMMP) algorithms to efficiently and effectively detect occupied channels at fusion center (FC), where multi-candidate identification and orthogonal projection are utilized to respectively reduce the number of required iterations and improve the probability of exact identification. Secondly, two common but different approaches based on threshold and Gaussian distribution are introduced to realize the multi-candidate identification. Moreover, to improve the detection accuracy and energy efficiency, we propose the matrix construction based on shrinkage and gradient descent (MCSGD) algorithm to provide a deterministic filter coefficient matrix of low t-average coherence. Finally, several numerical simulations validate that our proposals provide satisfactory performance with higher probability of detection, lower probability of false alarm and less detection time.

"I'm Not Teaching English, I'm Teaching Something Else!": How New Teachers Create Curriculum under Mandates of Educational Reform

ERIC Educational Resources Information Center

Costigan, Arthur

2018-01-01

This study presents how beginning teachers create and teach an English Language Arts (ELA) curriculum in urban schools in the context of an educational reform movement driven by mandates such as Common Core State Standards (CCSS), high stakes tests, and prescribed curricula. They serve in schools with each using unique and individual curricula due…

State Transition to High-Quality, College/Career-Ready Assessments: A Workbook for State Action on Key Policy, Legal, and Technical Issues. Updated

ERIC Educational Resources Information Center

Achieve, Inc., 2013

2013-01-01

Over the next few years, states will be transitioning to new, high-quality assessments aligned to the Common Core State Standards (CCSS) or other state college- and career-ready (CCR) standards. States are committed to making this transition in a manner that is determined and thoughtful--to help transform teaching and learning, advance CCR…

The Common Core: A Disaster for Libraries, a Disaster for Language Arts, a Disaster for American Education

ERIC Educational Resources Information Center

Krashen, Stephen

2014-01-01

This author contends that there never has been a need for the Common Core State Standards (CCSS), and there is no evidence that it will do students any good. The Common Core ignores the real problem in American education: poverty. The Common Core movement will be a disaster for libraries and will have a negative impact on nearly every aspect of…

How Business Leaders Can Support College and Career-Readiness: Staying the Course on Common Core. White Paper

ERIC Educational Resources Information Center

Meyer, Lori

2014-01-01

For the first time in the nation's history, a majority of students in the United States are learning based on a common set of standards for mathematics and English language arts (ELA) that will prepare them for the demands of the 21st century. The Common Core State Standards (CCSS) provide a clear, consistent framework for what students should…

Increased Expectations, Widening Gaps, and Opportunities to Engage Students: Extending the Conversation Begun by Cassidy, Ortlieb, and Grote-Garcia

ERIC Educational Resources Information Center

Fisher, Douglas; Frey, Nancy

2016-01-01

The Common Core State Standards (CCSS; National Governors Association [NGA] Center for Best Practices & Council of Chief State School Officers [CCSSO], 2010) are "hot," and authors Douglas Fisher and Nancy Frey think that is the way they should be. In this article they explain why they think that it is worth the time to focus on the…

Factor Structure of the Brief Symptom Inventory--18 in Adult Survivors of Childhood Cancer: Results from the Childhood Cancer Survivor Study

ERIC Educational Resources Information Center

Recklitis, Christopher J.; Parsons, Susan K.; Shih, Mei-Chiung; Mertens, Ann; Robison, Leslie L.; Zeltzer, Lonnie

2006-01-01

The factor structure of the Brief Symptom Inventory--18 (BSI-18; L. R. Derogatis, 2000) was investigated in a sample of adult survivors of childhood cancer enrolled in the Childhood Cancer Survivor Study (CCSS; N = 8,945). An exploratory factor analysis with a randomly chosen subsample supported a 3-factor structure closely corresponding to the 3…

Finding the Common Ground: A Comparison of Writing Expectations and Outcomes between the Texas Essential Knowledge and Skills and the Common Core State Standards

ERIC Educational Resources Information Center

Jacoby, Pat; Vasinda, Sheri

2014-01-01

In the Winter 2013 edition of the "Texas Journal of Literacy Education," we announced that a special task force from the TALE board would be sharing the common ground among the Texas Essential Knowledge and Skills (TEKS), Common Core State Standards (CCSS), and the College and Career Readiness Standards (CCRS). In that first edition, we…

Long-Term Positive and Negative Psychological Late Effects for Parents of Childhood Cancer Survivors: A Systematic Review

PubMed Central

Ljungman, Lisa; Cernvall, Martin; Grönqvist, Helena; Ljótsson, Brjánn; Ljungman, Gustaf; von Essen, Louise

2014-01-01

Increasing survival rates in childhood cancer have yielded a growing population of parents of childhood cancer survivors (CCSs). This systematic review compiles the literature on positive and negative long-term psychological late effects for parents of CCSs, reported at least five years after the child's diagnosis and/or two years after the end of the child's treatment. Systematic searches were made in the databases CINAHL, EMBASE, PsycINFO, and PubMed. Fifteen studies, published between 1988 and 2010, from 12 projects were included. Thirteen studies used quantitative methodology, one quantitative and qualitative methodology, and one qualitative methodology. A total of 1045 parents participated in the reviewed studies. Mean scores were within normal ranges for general psychological distress, coping, and family functioning. However, a substantial subgroup reported a clinical level of general psychological distress, and 21–44% reported a severe level of posttraumatic stress symptoms. Worry, disease-related thoughts and feelings, marital strains, as well as posttraumatic growth was reported. Several factors were associated with the long-term late effects, such as parents' maladaptive coping during earlier stages of the childs disease trajectory and children's current poor adjustment. Quality assessments of reviewed studies and clinical implications of findings are discussed and recommendations for future research are presented. PMID:25058607

Advanced Reading Comprehension Expectations in Secondary School: Considerations for Students with Emotional or Behavior Disorders

PubMed Central

Ciullo, Stephen; Ortiz, Miriam B.; Al Otaiba, Stephanie; Lane, Kathleen Lynne

2015-01-01

The debate around recent implementation of the Common Core Standards (CCSS) has perplexed many policy makers, practitioners, and researchers; yet there remains broad agreement for the need to improve reading outcomes and college and career readiness for all students, including students with disabilities. One of the most vulnerable populations with disabilities in terms of college and career readiness is students with emotional disorders (ED). A considerable percentage of students with ED encounter unfavorable academic and long-term outcomes, often due to reading difficulties and behavioral variables that impede learning. To date, the impact of rising expectations in reading on the education of students with ED has been absent from this conversation about CCSS. In this article, we consider the implications of new reading expectations in the critical period of Grades 6-12 for students with ED. First, we summarize grade level expectations of the standards. Then, we describe the characteristics and underachievement of students with ED. Next, we evaluate challenges in meeting the expectations based on extant research, and provide recommendations for practice based on the intervention literature. We conclude by prioritizing a research and policy agenda that advocates for increasing the likelihood of success in reading for students with ED in middle school and high school. PMID:27403040

A Review of Evidence Presented in Support of Three Key Claims in the Validity Argument for the "TextEvaluator"® Text Analysis Tool. Research Report. ETS RR-16-12

ERIC Educational Resources Information Center

Sheehan, Kathleen M.

2016-01-01

The "TextEvaluator"® text analysis tool is a fully automated text complexity evaluation tool designed to help teachers and other educators select texts that are consistent with the text complexity guidelines specified in the Common Core State Standards (CCSS). This paper provides an overview of the TextEvaluator measurement approach and…

Supplemental Information for Appendix A of the Common Core State Standards for English Language Arts and Literacy: New Research on Text Complexity

ERIC Educational Resources Information Center

Council of Chief State School Officers, 2017

2017-01-01

Appendix A of the Common Core State Standards (hereafter CCSS) contains a review of the research stressing the importance of being able to read complex text for success in college and career. The research shows that while the complexity of reading demands for college, career, and citizenship have held steady or risen over the past half century,…

Under Construction: Benchmark Assessments and Common Core Math Implementation in Grades K-8. Formative Evaluation Cycle Report for the Math in Common Initiative, Volume 1

ERIC Educational Resources Information Center

Flaherty, John, Jr.; Sobolew-Shubin, Alexandria; Heredia, Alberto; Chen-Gaddini, Min; Klarin, Becca; Finkelstein, Neal D.

2014-01-01

Math in Common® (MiC) is a five-year initiative that supports a formal network of 10 California school districts as they implement the Common Core State Standards in mathematics (CCSS-M) across grades K-8. As the MiC initiative moves into its second year, one of the central activities that each of the districts is undergoing to support CCSS…

Social Outcomes in the Childhood Cancer Survivor Study Cohort

PubMed Central

Gurney, James G.; Krull, Kevin R.; Kadan-Lottick, Nina; Nicholson, H. Stacy; Nathan, Paul C.; Zebrack, Brad; Tersak, Jean M.; Ness, Kirsten K.

2009-01-01

Difficulties with negotiating and achieving desired social outcomes in life may be exacerbated by the experience of childhood cancer, including adverse effects from therapies used to achieve a cure. This review of previous publications from the Childhood Cancer Survivor Study (CCSS) and other relevant literature provides insight into the prevalence of, and risk factors for, poor educational attainment, less than optimal employment status, and interpersonal relationship issues among long-term survivors of childhood cancer. The impacts of emotional health and physical disability on social outcomes are also examined. Study results suggest that childhood cancer survivors generally have similar high school graduation rates, but are more likely to require special education services than sibling comparison groups. Survivors are slightly less likely than expected to attend college, and are more likely to be unemployed and not married as young adults. Cancers and treatments that result in impairment to the CNS, particularly brain tumors, or that impact sensory functioning, such as hearing loss, are associated with greater risk for undesirable social outcomes, as are emotional health problems and physical disability. This review of relevant data from CCSS and other studies provides information on risk factors for social problems into adulthood. A greater understanding of the long-term social impacts from the diagnosis and treatment of childhood cancer is critically important for developing targeted interventions to prevent or ameliorate adverse psychosocial effects. PMID:19224833

Social outcomes in the Childhood Cancer Survivor Study cohort.

PubMed

Gurney, James G; Krull, Kevin R; Kadan-Lottick, Nina; Nicholson, H Stacy; Nathan, Paul C; Zebrack, Brad; Tersak, Jean M; Ness, Kirsten K

2009-05-10

Difficulties with negotiating and achieving desired social outcomes in life may be exacerbated by the experience of childhood cancer, including adverse effects from therapies used to achieve a cure. This review of previous publications from the Childhood Cancer Survivor Study (CCSS) and other relevant literature provides insight into the prevalence of, and risk factors for, poor educational attainment, less than optimal employment status, and interpersonal relationship issues among long-term survivors of childhood cancer. The impacts of emotional health and physical disability on social outcomes are also examined. Study results suggest that childhood cancer survivors generally have similar high school graduation rates, but are more likely to require special education services than sibling comparison groups. Survivors are slightly less likely than expected to attend college, and are more likely to be unemployed and not married as young adults. Cancers and treatments that result in impairment to the CNS, particularly brain tumors, or that impact sensory functioning, such as hearing loss, are associated with greater risk for undesirable social outcomes, as are emotional health problems and physical disability. This review of relevant data from CCSS and other studies provides information on risk factors for social problems into adulthood. A greater understanding of the long-term social impacts from the diagnosis and treatment of childhood cancer is critically important for developing targeted interventions to prevent or ameliorate adverse psychosocial effects.

Deciphering dynamics of clathrin-mediated endocytosis in a living organism

PubMed Central

Heidotting, Spencer P.; Huber, Scott D.

2016-01-01

Current understanding of clathrin-mediated endocytosis (CME) dynamics is based on detection and tracking of fluorescently tagged clathrin coat components within cultured cells. Because of technical limitations inherent to detection and tracking of single fluorescent particles, CME dynamics is not characterized in vivo, so the effects of mechanical cues generated during development of multicellular organisms on formation and dissolution of clathrin-coated structures (CCSs) have not been directly observed. Here, we use growth rates of fluorescence signals obtained from short CCS intensity trace fragments to assess CME dynamics. This methodology does not rely on determining the complete lifespan of individual endocytic assemblies. Therefore, it allows for real-time monitoring of spatiotemporal changes in CME dynamics and is less prone to errors associated with particle detection and tracking. We validate the applicability of this approach to in vivo systems by demonstrating the reduction of CME dynamics during dorsal closure of Drosophila melanogaster embryos. PMID:27458134

Inference with viral quasispecies diversity indices: clonal and NGS approaches.

PubMed

Gregori, Josep; Salicrú, Miquel; Domingo, Esteban; Sanchez, Alex; Esteban, Juan I; Rodríguez-Frías, Francisco; Quer, Josep

2014-04-15

Given the inherent dynamics of a viral quasispecies, we are often interested in the comparison of diversity indices of sequential samples of a patient, or in the comparison of diversity indices of virus in groups of patients in a treated versus control design. It is then important to make sure that the diversity measures from each sample may be compared with no bias and within a consistent statistical framework. In the present report, we review some indices often used as measures for viral quasispecies complexity and provide means for statistical inference, applying procedures taken from the ecology field. In particular, we examine the Shannon entropy and the mutation frequency, and we discuss the appropriateness of different normalization methods of the Shannon entropy found in the literature. By taking amplicons ultra-deep pyrosequencing (UDPS) raw data as a surrogate of a real hepatitis C virus viral population, we study through in-silico sampling the statistical properties of these indices under two methods of viral quasispecies sampling, classical cloning followed by Sanger sequencing (CCSS) and next-generation sequencing (NGS) such as UDPS. We propose solutions specific to each of the two sampling methods-CCSS and NGS-to guarantee statistically conforming conclusions as free of bias as possible. josep.gregori@gmail.com Supplementary information: Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Engaging Students In The Science Of Climate Change

NASA Astrophysics Data System (ADS)

Rhew, R. C.; Halversen, C.; Weiss, E.; Pedemonte, S.; Weirman, T.

2013-12-01

Climate change is arguably the defining environmental issue of our generation. It is thus increasingly necessary for every member of the global community to understand the basic underlying science of Earth's climate system and how it is changing in order to make informed, evidence-based decisions about how we will respond individually and as a society. Through exploration of the inextricable interconnection between Earth's ocean, atmosphere and climate, we believe students will be better prepared to tackle the complex issues surrounding the causes and effects of climate change and evaluate possible solutions. If students are also given opportunities to gather evidence from real data and use scientific argumentation to make evidence-based explanations about climate change, not only will they gain an increased understanding of the science concepts and science practices, the students will better comprehend the nature of climate change science. Engaging in argument from evidence is a scientific practice not only emphasized in the Framework for K-12 Science Education and the Next Generation Science Standards (NGSS), but also emphasized in the Common Core State Standards for English Language Arts & Literacy in History/Social Studies and Science (CCSS). This significant overlap between NGSS and CCSS has implications for science and language arts classrooms, and should influence how we support and build students' expertise with this practice of sciences. The featured exemplary curricula supports middle school educators as they address climate change in their classrooms. The exemplar we will use is the NOAA-funded Ocean Sciences Sequence (OSS) for Grades 6-8: The ocean-atmosphere connection and climate change, which are curriculum units that deliver rich science content correlated to the Next Generation Science Standards (NGSS) Disciplinary Core Ideas and an emphasis on the Practices of Science, as called for in NGSS and the Framework. Designed in accordance with the latest research on learning this curriculum provides numerous opportunities for students to use real data to make evidence-based explanations. During the session, we will discuss ways in which students can use scientific data related to climate change as evidence in their construction of scientific arguments.

What's Learned First, What's Learned Together? Developing a Yearlong Plan from the K-12 College and Career Ready Standards for English Language Arts and Literacy. From the College and Career Ready Standards to Teaching and Learning in the Classroom: A Series of Resources for Teachers. Updated August 2015

ERIC Educational Resources Information Center

Mancevice, Nicole; Lozano, Maritza; Jones, Barbara; Tobiason, Glory; Heritage, Margaret; Chang, Sandy; Herman, Joan

2015-01-01

This resource is part of a series produced by the Center for Standards and Assessment Implementation (CSAI) to assist educators as they use College and Career Ready Standards (CCRS) to plan instruction for diverse learners. Although the processes described in this resource use the Common Core State Standards (CCSS; National Governors Association…

How Well Are American Students Learning? With Sections on Reading and Math in the Common Core Era, Tracking and Advanced Placement (AP), and Principals as Instructional Leaders. The 2016 Brown Center Report on American Education. Volume 3, Number 5

ERIC Educational Resources Information Center

Loveless, Tom

2016-01-01

The 2016 edition of the Brown Center Report (BCR) is number five in the third volume and the 15th issue overall. As is customary, this year's BCR contains three studies. Part one is on the Common Core State Standards (CCSS) and instruction in math and reading. National Assessment of Educational Progress (NAEP) data indicate that nonfiction is…

Enhancing Parent Involvement in NC-CCSS for K-2 Mathematics

NASA Astrophysics Data System (ADS)

Johnson, D.

2014-12-01

Key Terms:Parent Involvement, Common Core State Standards, Homework, K - 2 Mathematics In this study, the 2014 REU math team developed and provided a workshop that assisted parents in understanding the North Carolina Common Core State Standards for K-2 Mathematics to assist with student homework assignments. Parent involvement is defined as parent participating in the educational processes and experiences of their children. A chi-square analysis was used to analyze data collected from the pre survey and the post survey administered to participants in the workshop. The study revealed all of the individual components of parent involvement were positively and significantly related to educational goals. The study identified various aspects of parent involvement that yielded statistically significant results in affirming that parent involvement attributed to urban student achievement. These findings were particularly helpful for indicating which kinds of parent involvement influenced academic success. Most notably, parent expectations and styles demonstrated a strong relationship with scholastic outcomes. Parent expectations and styles created an educationally oriented ambience that established an understanding of the certain level of support the child needed to succeed academically. The REU mathematics team focused on three essential questions in this study: (1) What practices will increase parent awareness of K-2 NC-CCSS for mathematics at P. W. Moore Elementary School? (2) What methods can be used to strengthen parent skills in assisting with mathematics homework assignments at P. W. Moore Elementary School? (3) What actions can be taken to motivate parent involvement in the school improvement process focusing on mathematics at P. W. Moore Elementary School?

A practical approach to the clinical diagnosis of Ewing's sarcoma/primitive neuroectodermal tumour and other small round cell tumours sharing EWS rearrangement using new fluorescence in situ hybridisation probes for EWSR1 on formalin fixed, paraffin wax embedded tissue.

PubMed

Yamaguchi, U; Hasegawa, T; Morimoto, Y; Tateishi, U; Endo, M; Nakatani, F; Kawai, A; Chuman, H; Beppu, Y; Endo, M; Kurotaki, H; Furuta, K

2005-10-01

Over 90% of Ewing's sarcoma/primitive neuroectodermal tumour (ES/PNET) cases have the t(11;22) chromosomal rearrangement, which is also found in other small round cell tumours, including desmoplastic small round cell tumour (DSRCT) and clear cell sarcoma (CCS). Although this rearrangement can be analysed by fluorescence in situ hybridisation (FISH) using routinely formalin fixed, paraffin wax embedded (FFPE) tissues when fresh or frozen tissues are not available, a sensitive and convenient detection method is needed for routine clinical diagnosis. To investigate the usefulness of newly developed probes for detecting EWS rearrangement resulting from chromosomal translocations using FISH and FFPE tissue in the clinical diagnosis of ES/PNET, DSRCT, and CCS. Sixteen ES/PNETs, six DSRCTs, and six CCSs were studied. Three poorly differentiated synovial sarcomas, three alveolar rhabdomyosarcomas, and three neuroblastomas served as negative controls. Interphase FISH analysis was performed on FFPE tissue sections with a commercially available EWSR1 (22q12) dual colour, breakapart rearrangement probe. One fused signal and one split signal of orange and green, demonstrating rearrangement of the EWS gene, was detected in 14 of 16 ES/PNETs, all six DRSCTs, and five of six CCSs, but not in the negative controls. Interphase FISH using this newly developed probe is sensitive and specific for detecting the EWS gene on FFPE tissues and is of value in the routine clinical diagnosis of ES/PNET, DSRCT, and CCS.

Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boukheris, Houda; Stovall, Marilyn; Gilbert, Ethel S.

Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 casesmore » of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.« less

Second Neoplasms in Survivors of Childhood Cancer: Findings From the Childhood Cancer Survivor Study Cohort

PubMed Central

Meadows, Anna T.; Friedman, Debra L.; Neglia, Joseph P.; Mertens, Ann C.; Donaldson, Sarah S.; Stovall, Marilyn; Hammond, Sue; Yasui, Yutaka; Inskip, Peter D.

2009-01-01

Purpose To review the reports of subsequent neoplasms (SNs) in the Childhood Cancer Survivor Study (CCSS) cohort that were made through January 1, 2006, and published before July 31, 2008, and to discuss the host-, disease-, and therapy-related risk factors associated with SNs. Patients and Methods SNs were ascertained by survivor self-reports and subsequently confirmed by pathology findings or medical record review. Cumulative incidence of SNs and standardized incidence ratios for second malignant neoplasms (SMNs) were calculated. The impact of host-, disease-, and therapy-related risk factors was evaluated by Poisson regression. Results Among 14,358 cohort members, 730 reported 802 SMNs (excluding nonmelanoma skin cancers). This represents a 2.3-fold increase in the number of SMNs over that reported in the first comprehensive analysis of SMNs in the CCSS cohort, which was done 7 years ago. In addition, 66 cases of meningioma and 1,007 cases of nonmelanoma skin cancer were diagnosed. The 30-year cumulative incidence of SMNs was 9.3% and that of nonmelanoma skin cancer was 6.9%. Risk of SNs remains elevated for more than 20 years of follow-up for all primary childhood cancer diagnoses. In multivariate analyses, risks differ by SN subtype, but include radiotherapy, age at diagnosis, sex, family history of cancer, and primary childhood cancer diagnosis. Female survivors whose primary childhood cancer diagnosis was Hodgkin's lymphoma or sarcoma and who received radiotherapy are at particularly increased risk. Analyses of risk associated with radiotherapy demonstrated different dose-response curves for specific SNs. Conclusion Childhood cancer survivors are at a substantial and increasing risk for SNs, including nonmelanoma skin cancer and meningiomas. Health care professionals should understand the magnitude of these risks to provide individuals with appropriate counseling and follow-up. PMID:19255307

Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors.

PubMed

Sherborne, Amy L; Lavergne, Vincent; Yu, Katharine; Lee, Leah; Davidson, Philip R; Mazor, Tali; Smirnoff, Ivan V; Horvai, Andrew E; Loh, Mignon; DuBois, Steven G; Goldsby, Robert E; Neglia, Joseph P; Hammond, Sue; Robison, Leslie L; Wustrack, Rosanna; Costello, Joseph F; Nakamura, Alice O; Shannon, Kevin M; Bhatia, Smita; Nakamura, Jean L

2017-04-01

Purpose: Second malignant neoplasms (SMNs) are severe late complications that occur in pediatric cancer survivors exposed to radiotherapy and other genotoxic treatments. To characterize the mutational landscape of treatment-induced sarcomas and to identify candidate SMN-predisposing variants, we analyzed germline and SMN samples from pediatric cancer survivors. Experimental Design: We performed whole-exome sequencing (WES) and RNA sequencing on radiation-induced sarcomas arising from two pediatric cancer survivors. To assess the frequency of germline TP53 variants in SMNs, Sanger sequencing was performed to analyze germline TP53 in 37 pediatric cancer survivors from the Childhood Cancer Survivor Study (CCSS) without any history of a familial cancer predisposition syndrome but known to have developed SMNs. Results: WES revealed TP53 mutations involving p53's DNA-binding domain in both index cases, one of which was also present in the germline. The germline and somatic TP53- mutant variants were enriched in the transcriptomes for both sarcomas. Analysis of TP53- coding exons in germline specimens from the CCSS survivor cohort identified a G215C variant encoding an R72P amino acid substitution in 6 patients and a synonymous SNP A639G in 4 others, resulting in 10 of 37 evaluable patients (27%) harboring a germline TP53 variant. Conclusions: Currently, germline TP53 is not routinely assessed in patients with pediatric cancer. These data support the concept that identifying germline TP53 variants at the time a primary cancer is diagnosed may identify patients at high risk for SMN development, who could benefit from modified therapeutic strategies and/or intensive posttreatment monitoring. Clin Cancer Res; 23(7); 1852-61. ©2016 AACR . ©2016 American Association for Cancer Research.

Somatic and germline TP53 alterations in second malignant neoplasms from pediatric cancer survivors

PubMed Central

Sherborne, Amy L.; Lavergne, Vincent; Yu, Katharine; Lee, Leah; Davidson, Philip R.; Mazor, Tali; Smirnoff, Ivan; Horvai, Andrew; Loh, Mignon; DuBois, Steven G.; Goldsby, Robert E.; Neglia, Joseph; Hammond, Sue; Robison, Leslie L.; Wustrack, Rosanna; Costello, Joseph; Nakamura, Alice O.; Shannon, Kevin; Bhatia, Smita; Nakamura, Jean L.

2016-01-01

Purpose Second malignant neoplasms (SMNs) are severe late complications that occur in pediatric cancer survivors exposed to radiotherapy and other genotoxic treatments. To characterize the mutational landscape of treatment-induced sarcomas and to identify candidate SMN-predisposing variants we analyzed germline and SMN samples from pediatric cancer survivors. Experimental Design We performed whole exome sequencing (WES) and RNA sequencing on radiation-induced sarcomas arising from two pediatric cancer survivors. To assess the frequency of germline TP53 variants in SMNs, Sanger sequencing was performed to analyze germline TP53 in thirty-seven pediatric cancer survivors from the Childhood Cancer Survivor Study (CCSS) without history of a familial cancer predisposition syndrome but known to have developed SMNs. Results WES revealed TP53 mutations involving p53’s DNA binding domain in both index cases, one of which was also present in the germline. The germline and somatic TP53 mutant variants were enriched in the transcriptomes for both sarcomas. Analysis of TP53 coding exons in germline specimens from the CCSS survivor cohort identified a G215C variant encoding an R72P amino acid substitution in six patients and a synonymous single nucleotide polymorphism A639G in four others, resulting in ten out of 37 evaluable patients (27%) harboring a germline TP53 variant. Conclusions Currently, germline TP53 is not routinely assessed in pediatric cancer patients. These data support the concept that identifying germline TP53 variants at the time a primary cancer is diagnosed may identify patients at high risk for SMN development, who could benefit from modified therapeutic strategies and/or intensive post-treatment monitoring. PMID:27683180

Tobacco Use Among Siblings of Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study.

PubMed

Buchbinder, David; Oeffinger, Kevin; Franco-Villalobos, Conrado; Yasui, Yutaka; Alderfer, Melissa A; Armstrong, Gregory T; Casillas, Jacqueline; Ford, Jennifer; Krull, Kevin R; Leisenring, Wendy; Recklitis, Christopher; Robison, Leslie L; Zeltzer, Lonnie K; Lown, E Anne

2016-02-01

Having a brother or sister with childhood cancer may influence health behaviors during adulthood. The aim of this study was to compare tobacco use in siblings of survivors with peers and to identify factors associated with sibling tobacco use. A retrospective cohort study was conducted using adult siblings (N = 1,974) of 5+ year cancer survivors in the Childhood Cancer Survivor Study (CCSS) and participants (N = 24,105, weighted to match CCSS) in the 2007 National Health Interview Survey. Self-reported tobacco use, sociodemographic, and cancer-related risk factors were analyzed. Siblings were equally likely to have ever smoked compared to their peers (odds ratio [OR] 1.02, 95% confidence interval [CI] 0.93-1.12). Siblings were less likely to be current smokers (OR 0.83, 95%CI 0.73-0.94), but more likely to be former smokers (OR 1.21, 95%CI 1.08-1.35). Siblings with low education were more likely to ever smoke (OR 1.51, 95%CI 1.15-2.00) and be current smokers (OR 1.67, 95%CI 1.24-2.26) compared to their peers. Among siblings, risk factors for current tobacco use included the following: low income <$20,000 (OR 1.66, 95%CI 1.09-2.54), low education (OR 6.68, 95%CI 4.07-10.97), psychological distress (OR 5.36, 95%CI 2.21-13.02), and heavy alcohol use (OR 3.68, 95%CI 2.50-5.41). Siblings of survivors take up smoking at similar rates to their peers, but are more likely to quit. Efforts are needed to address disparities by providing greater psychosocial support and education for the lowest socioeconomic status families facing childhood cancer. © 2015 Wiley Periodicals, Inc.

The development, testing, and preliminary feasibility of an adaptable pediatric oncology nutrition algorithm for low-middle income countries.

PubMed

Fleming, C A K; Viani, K; Murphy, A J; Mosby, T T; Arora, B; Schoeman, J; Ladas, E J

2015-01-01

Survivors of childhood cancer are at increased risk for several cardiometabolic complications. Obesity/overweight and metabolic syndrome have been widely reported in Western literature, but data from India are lacking. To perform an objective assessment of nutritional status in a cohort of childhood cancer survivors (CCSs) and to find risk factors for extremes in nutritional status. The study was a retrospective chart review of CCSs who attended the late effects clinic of a referral pediatric oncology center over the period of 1 year. An objective assessment of nutritional status was done, and results were analyzed in two groups: Adult survivors (present age <18 years) and child and adolescent survivors (CASs) (<18 years). The data were then analyzed for possible risk factors. Six hundred and forty-eight survivors were included in the study; of these, 471 were <18 years at follow-up, and 177 were 18 years or older. The prevalence of obesity, overweight, normal, and undernutrition was 2.6%, 10.8%, 62.7%, and 28.8% (CASs) and 0%, 8.5%, 62.7%, and 28.8% (adult survivors), respectively. Factors predictive of overweight/obesity were an initial diagnosis of acute lymphoblastic leukemia, or brain tumor and follow-up duration of >20 years or current age >30 years in adult survivors. The prevalence of obesity/overweight is lower in our cohort when compared to Western literature. It remains to be clarified whether this reflects the underlying undernutrition in our country, or whether our cohort of survivors is indeed distinct from their Western counterparts. Comparison with age/sex-matched normal controls and baseline parameters would yield more meaningful results.

Nutritional status in survivors of childhood cancer: Experience from Tata Memorial Hospital, Mumbai.

PubMed

Prasad, M; Arora, B; Chinnaswamy, G; Vora, T; Narula, G; Banavali, S; Kurkure, P

2015-01-01

Survivors of childhood cancer are at increased risk for several cardiometabolic complications. Obesity/overweight and metabolic syndrome have been widely reported in Western literature, but data from India are lacking. To perform an objective assessment of nutritional status in a cohort of childhood cancer survivors (CCSs) and to find risk factors for extremes in nutritional status. The study was a retrospective chart review of CCSs who attended the late effects clinic of a referral pediatric oncology center over the period of 1 year. An objective assessment of nutritional status was done, and results were analyzed in two groups: Adult survivors (present age <18 years) and child and adolescent survivors (CASs) (<18 years). The data were then analyzed for possible risk factors. Six hundred and forty-eight survivors were included in the study; of these, 471 were <18 years at follow-up, and 177 were 18 years or older. The prevalence of obesity, overweight, normal, and undernutrition was 2.6%, 10.8%, 62.7%, and 28.8% (CASs) and 0%, 8.5%, 62.7%, and 28.8% (adult survivors), respectively. Factors predictive of overweight/obesity were an initial diagnosis of acute lymphoblastic leukemia, or brain tumor and follow-up duration of >20 years or current age >30 years in adult survivors. The prevalence of obesity/overweight is lower in our cohort when compared to Western literature. It remains to be clarified whether this reflects the underlying undernutrition in our country, or whether our cohort of survivors is indeed distinct from their Western counterparts. Comparison with age/sex-matched normal controls and baseline parameters would yield more meaningful results.

Gas-Phase Analysis of the Complex of Fibroblast GrowthFactor 1 with Heparan Sulfate: A Traveling Wave Ion Mobility Spectrometry (TWIMS) and Molecular Modeling Study

NASA Astrophysics Data System (ADS)

Zhao, Yuejie; Singh, Arunima; Xu, Yongmei; Zong, Chengli; Zhang, Fuming; Boons, Geert-Jan; Liu, Jian; Linhardt, Robert J.; Woods, Robert J.; Amster, I. Jonathan

2017-01-01

Fibroblast growth factors (FGFs) regulate several cellular developmental processes by interacting with cell surface heparan proteoglycans and transmembrane cell surface receptors (FGFR). The interaction of FGF with heparan sulfate (HS) is known to induce protein oligomerization, increase the affinity of FGF towards its receptor FGFR, promoting the formation of the HS-FGF-FGFR signaling complex. Although the role of HS in the signaling pathways is well recognized, the details of FGF oligomerization and formation of the ternary signaling complex are still not clear, with several conflicting models proposed in literature. Here, we examine the effect of size and sulfation pattern of HS upon FGF1 oligomerization, binding stoichiometry and conformational stability, through a combination of ion mobility (IM) and theoretical modeling approaches. Ion mobility-mass spectrometry (IMMS) of FGF1 in the presence of several HS fragments ranging from tetrasaccharide (dp4) to dodecasaccharide (dp12) in length was performed. A comparison of the binding stoichiometry of variably sulfated dp4 HS to FGF1 confirmed the significance of the previously known high-affinity binding motif in FGF1 dimerization, and demonstrated that certain tetrasaccharide-length fragments are also capable of inducing dimerization of FGF1. The degree of oligomerization was found to increase in the presence of dp12 HS, and a general lack of specificity for longer HS was observed. Additionally, collision cross-sections (CCSs) of several FGF1-HS complexes were calculated, and were found to be in close agreement with experimental results. Based on the (CCSs) a number of plausible binding modes of 2:1 and 3:1 FGF1-HS are proposed.

Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study.

PubMed

Kirchhoff, Anne C; Leisenring, Wendy; Krull, Kevin R; Ness, Kirsten K; Friedman, Debra L; Armstrong, Gregory T; Stovall, Marilyn; Park, Elyse R; Oeffinger, Kevin C; Hudson, Melissa M; Robison, Leslie L; Wickizer, Thomas

2010-11-01

Adult childhood cancer survivors report high levels of unemployment, although it is unknown whether this is because of health or employability limitations. We examined 2 employment outcomes from 2003 in the Childhood Cancer Survivor Study (CCSS): (1) health-related unemployment and (2) unemployed but seeking work. We compared survivors with a nearest-age CCSS sibling cohort and examined demographic and treatment-related risk groups for each outcome. We studied 6339 survivors and 1967 siblings ≥25 years of age excluding those unemployed by choice. Multivariable generalized linear models evaluated whether survivors were more likely to be unemployed than siblings and whether certain survivors were at a higher risk for unemployment. Survivors (10.4%) reported health-related unemployment more often than siblings (1.8%; Relative Risk [RR], 6.07; 95% Confidence Interval [CI], 4.32-8.53). Survivors (5.7%) were more likely to report being unemployed but seeking work than siblings (2.7%; RR, 1.90; 95% CI, 1.43-2.54). Health-related unemployment was more common in female survivors than males (Odds Ratio [OR], 1.73; 95% CI, 1.43-2.08). Cranial radiotherapy doses ≥25 Gy were associated with higher odds of unemployment (health-related: OR, 3.47; 95% CI, 2.54-4.74; seeking work: OR, 1.77; 95% CI, 1.15-2.71). Unemployed survivors reported higher levels of poor physical functioning than employed survivors, and had lower education and income and were more likely to be publicly insured than unemployed siblings. Childhood cancer survivors have higher levels of unemployment because of health or being between jobs. High-risk survivors may need vocational assistance.

Promoting Scientific Thinking and Conceptual Change about Alternative Explanations of Climate Change and Other Controversial Socio-scientific Topics

NASA Astrophysics Data System (ADS)

Lombardi, D.; Sinatra, G. M.

2013-12-01

Critical evaluation and plausibility reappraisal of scientific explanations have been underemphasized in many science classrooms (NRC, 2012). Deep science learning demands that students increase their ability to critically evaluate the quality of scientific knowledge, weigh alternative explanations, and explicitly reappraise their plausibility judgments. Therefore, this lack of instruction about critical evaluation and plausibility reappraisal has, in part, contributed to diminished understanding about complex and controversial topics, such as global climate change. The Model-Evidence Link (MEL) diagram (originally developed by researchers at Rutgers University under an NSF-supported project; Chinn & Buckland, 2012) is an instructional scaffold that promotes students to critically evaluate alternative explanations. We recently developed a climate change MEL and found that the students who used the MEL experienced a significant shift in their plausibility judgments toward the scientifically accepted model of human-induced climate change. Using the MEL for instruction also resulted in conceptual change about the causes of global warming that reflected greater understanding of fundamental scientific principles. Furthermore, students sustained this conceptual change six months after MEL instruction (Lombardi, Sinatra, & Nussbaum, 2013). This presentation will discuss recent educational research that supports use of the MEL to promote critical evaluation, plausibility reappraisal, and conceptual change, and also, how the MEL may be particularly effective for learning about global climate change and other socio-scientific topics. Such instruction to develop these fundamental thinking skills (e.g., critical evaluation and plausibility reappraisal) is demanded by both the Next Generation Science Standards (Achieve, 2013) and the Common Core State Standards for English Language Arts and Mathematics (CCSS Initiative-ELA, 2010; CCSS Initiative-Math, 2010), as well as a society that is equipped to deal with challenges in a way that is beneficial to our national and global community.

Creating Next Generation Teacher Preparation Programs to Support Implementation of the Next Generation Science Standards and Common Core State Standards in K-12 Schools: An Opportunity for the Earth and Space Sciences

NASA Astrophysics Data System (ADS)

Geary, E. E.; Egger, A. E.; Julin, S.; Ronca, R.; Vokos, S.; Ebert, E.; Clark-Blickenstaff, J.; Nollmeyer, G.

2015-12-01

A consortium of two and four year Washington State Colleges and Universities in partnership with Washington's Office of the Superintendent of Public Instruction (OSPI), the Teachers of Teachers of Science, and Teachers of Teachers of Mathematics, and other key stakeholders, is currently working to improve science and mathematics learning for all Washington State students by creating a new vision for STEM teacher preparation in Washington State aligned with the Next Generation Science Standards (NGSS) and the Common Core State Standards (CCSS) in Mathematics and Language Arts. Specific objectives include: (1) strengthening elementary and secondary STEM Teacher Preparation courses and curricula, (2) alignment of STEM teacher preparation programs across Washington State with the NGSS and CCSS, (3) development of action plans to support implementation of STEM Teacher Preparation program improvement at Higher Education Institutions (HEIs) across the state, (4) stronger collaborations between HEIs, K-12 schools, government agencies, Non-Governmental Organizations, and STEM businesses, involved in the preparation of preservice STEM teachers, (5) new teacher endorsements in Computer Science and Engineering, and (6) development of a proto-type model for rapid, adaptable, and continuous improvement of STEM teacher preparation programs. A 2015 NGSS gap analysis of teacher preparation programs across Washington State indicates relatively good alignment of courses and curricula with NGSS Disciplinary Core Ideas and Scientific practices, but minimal alignment with NGSS Engineering practices and Cross Cutting Concepts. Likewise, Computer Science and Sustainability ideas and practices are not well represented in current courses and curricula. During the coming year teams of STEM faculty, education faculty and administrators will work collaboratively to develop unique action plans for aligning and improving STEM teacher preparation courses and curricula at their institutions.

Experimental and Model Studies on Continuous Separation of 2-Phenylpropionic Acid Enantiomers by Enantioselective Liquid-Liquid Extraction in Centrifugal Contactor Separators.

PubMed

Feng, Xiaofeng; Tang, Kewen; Zhang, Pangliang; Yin, Shuangfeng

2016-03-01

Multistage enantioselective liquid-liquid extraction (ELLE) of 2-phenylpropionic acid (2-PPA) enantiomers using hydroxypropyl-β-cyclodextrin (HP-β-CD) as extractant was studied experimentally in a counter-current cascade of centrifugal contactor separators (CCSs). Performance of the process was evaluated by purity (enantiomeric excess, ee) and yield (Y). A multistage equilibrium model was established on the basis of single-stage model for chiral extraction of 2-PPA enantiomers and the law of mass conservation. A series of experiments on the extract phase/washing phase ratio (W/O ratio), extractant concentration, the pH value of aqueous phase, and the number of stages was conducted to verify the multistage equilibrium model. It was found that model predictions were in good agreement with the experimental results. The model was applied to predict and optimize the symmetrical separation of 2-PPA enantiomers. The optimal conditions for symmetric separation involves a W/O ratio of 0.6, pH of 2.5, and HP-β-CD concentration of 0.1 mol L(-1) at a temperature of 278 K, where eeeq (equal enantiomeric excess) can reach up to 37% and Yeq (equal yield) to 69%. By simulation and optimization, the minimum number of stages was evaluated at 98 and 106 for eeeq > 95% and eeeq > 97%. © 2016 Wiley Periodicals, Inc.

Tobacco Use Among Siblings of Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study

PubMed Central

Buchbinder, David; Oeffinger, Kevin; Franco-Villalobos, Conrado; Yasui, Yutaka; Alderfer, Melissa A.; Armstrong, Gregory T.; Casillas, Jacqueline; Ford, Jennifer; Krull, Kevin R.; Leisenring, Wendy; Recklitis, Christopher; Robison, Leslie L.; Zeltzer, Lonnie K.; Lown, E. Anne

2015-01-01

Background Having a brother or sister with childhood cancer may influence health behaviors during adulthood. The aim of this study was to compare tobacco use in siblings of survivors with peers and to identify factors associated with sibling tobacco use. Procedures A retrospective cohort study was conducted using adult siblings (N=1,974) of 5+ year cancer survivors in the Childhood Cancer Survivor Study (CCSS) and participants (N=24,105, weighted to match CCSS) in the 2007 National Health Interview Survey. Self-reported tobacco use, sociodemographic, and cancer-related risk factors were analyzed. Results Siblings were equally likely to have ever smoked compared to their peers, (Odds Ratio [OR] 1.02, 95% Confidence Interval [CI] 0.93–1.12). Siblings were less likely to be current smokers (OR 0.83, 95% CI 0.73–0.94), but more likely to be former smokers (OR 1.21, 95% CI 1.08–1.35). Siblings with low education were more likely to ever smoke (OR 1.51, 95% CI 1.15–2.00) and be current smokers (OR 1.67, 95% CI 1.24–2.26) compared to their peers. Among siblings, risk factors for current tobacco use included: low income <$20,000 (OR 1.66, 95% CI 1.09–2.54), low education (OR 6.68, 95% CI 4.07–10.97), psychological distress (OR 5.36, 95% CI 2.21–13.02), and heavy alcohol use (OR 3.68, 95% CI 2.50–5.41). Conclusions Siblings of survivors take up smoking at similar rates to their peers, but are more likely to quit. Efforts are needed to address disparities by providing greater psychosocial support and education for the lowest socio-economic status families facing childhood cancer. PMID:26305712

Reductions in Average Lengths of Stays for Surgical Procedures Between the 2008 and 2014 United States National Inpatient Samples Were Not Associated With Greater Incidences of Use of Postacute Care Facilities.

PubMed

Dexter, Franklin; Epstein, Richard H

2018-03-01

Diagnosis-related group (DRG) based reimbursement creates incentives for reduction in hospital length of stay (LOS). Such reductions might be accomplished by lesser incidences of discharges to home. However, we previously reported that, while controlling for DRG, each 1-day decrease in hospital median LOS was associated with lesser odds of transfer to a postacute care facility (P = .0008). The result, though, was limited to elective admissions, 15 common surgical DRGs, and the 2013 US National Readmission Database. We studied the same potential relationship between decreased LOS and postacute care using different methodology and over 2 different years. The observational study was performed using summary measures from the 2008 and 2014 US National Inpatient Sample, with 3 types of categories (strata): (1) Clinical Classifications Software's classes of procedures (CCS), (2) DRGs including a major operating room procedure during hospitalization, or (3) CCS limiting patients to those with US Medicare as the primary payer. Greater reductions in the mean LOS were associated with smaller percentages of patients with disposition to postacute care. Analyzed using 72 different CCSs, 174 DRGs, or 70 CCSs limited to Medicare patients, each pairwise reduction in the mean LOS by 1 day was associated with an estimated 2.6% ± 0.4%, 2.3% ± 0.3%, or 2.4% ± 0.3% (absolute) pairwise reduction in the mean incidence of use of postacute care, respectively. These 3 results obtained using bivariate weighted least squares linear regression were all P < .0001, as were the corresponding results obtained using unweighted linear regression or the Spearman rank correlation. In the United States, reductions in hospital LOS, averaged over many surgical procedures, are not accomplished through a greater incidence of use of postacute care.

Risk Factors for Obesity in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

PubMed Central

Green, Daniel M.; Cox, Cheryl L.; Zhu, Liang; Krull, Kevin R.; Srivastava, Deo Kumar; Stovall, Marilyn; Nolan, Vikki G.; Ness, Kirsten K.; Donaldson, Sarah S.; Oeffinger, Kevin C.; Meacham, Lillian R.; Sklar, Charles A.; Armstrong, Gregory T.; Robison, Leslie L.

2012-01-01

Purpose Many Childhood Cancer Survivor Study (CCSS) participants are at increased risk for obesity. The etiology of their obesity is likely multifactorial but not well understood. Patients and Methods We evaluated the potential contribution of demographic, lifestyle, treatment, and intrapersonal factors and self-reported pharmaceutical use to obesity (body mass index ≥ 30 kg/m2) among 9,284 adult (> 18 years of age) CCSS participants. Independent predictors were identified using multivariable regression models. Interrelationships were determined using structural equation modeling (SEM). Results Independent risk factors for obesity included cancer diagnosed at 5 to 9 years of age (relative risk [RR], 1.12; 95% CI, 1.01 to 1.24; P = .03), abnormal Short Form–36 physical function (RR, 1.19; 95% CI, 1.06 to 1.33; P < .001), hypothalamic/pituitary radiation doses of 20 to 30 Gy (RR, 1.17; 95% CI, 1.05 to 1.30; P = .01), and paroxetine use (RR, 1.29; 95% CI, 1.08 to 1.54; P = .01). Meeting US Centers for Disease Control and Prevention guidelines for vigorous physical activity (RR, 0.90; 95% CI, 0.82 to 0.97; P = .01) and a medium amount of anxiety (RR, 0.86; 95% CI, 0.75 to 0.99; P = .04) reduced the risk of obesity. Results of SEM (N = 8,244; comparative fit index = 0.999; Tucker Lewis index = 0.999; root mean square error of approximation = 0.014; weighted root mean square residual = 0.749) described the hierarchical impact of the direct predictors, moderators, and mediators of obesity. Conclusion Treatment, lifestyle, and intrapersonal factors, as well as the use of specific antidepressants, may contribute to obesity among survivors. A multifaceted intervention, including alternative drug and other therapies for depression and anxiety, may be required to reduce risk. PMID:22184380

Quality of life and sexual function of patients following radical hysterectomy and vaginal extension.

PubMed

Ye, Shuang; Yang, Jiaxin; Cao, Dongyan; Zhu, Lan; Lang, Jinghe; Chuang, Linus T; Shen, Keng

2014-05-01

Radical hysterectomy (RH) has negative consequences on sexual function due to a shortened vagina, vaginal dryness, and dyspareunia. Peritoneovaginoplasty aims to extend vagina by vesical peritoneum and anterior rectal wall to improve postoperative sexual function. The aim of this study was to investigate whether vaginal extension can improve sexual function and quality of life and the problem of sexual dysfunction in early-stage cervical cancer survivors (CCSs) in China. Case-control and questionnaire-based methods were employed. Thirty-one patients who had undergone vaginal extension following RH and 28 patients with matching factors after RH alone were enrolled in the study. Both groups were assessed retrospectively by questionnaires at least 6 months after treatment. The European Organization for Research and Treatment of Cancer Quality-of-Life questionnaire cervical cancer module and the Sexual Function Vaginal Changes Questionnaire are validated measurements for disease- and treatment-specific issues. Vaginal length was 10.03 ± 1.26 cm and 5.92 ± 1.05 cm in study and control group, respectively (P < 0.05). In the study group, 67.7% patients and 64.3% of control group resumed sexual activity at the time of interview, averaging 6 months between treatment and sexual activity. While difficulty emptying bladder, incomplete emptying, and constipation were the most commonly reported symptoms, no significant difference was observed regarding pelvic floor symptoms. Reduced vagina size and shortened vagina was significantly more prominent in the control group, whereas both group presented with hypoactive sexual desire (88.1%), orgasm dysfunction (71.8%), and low enjoyment or relaxation after sex (51.3%). Shortened vagina was significantly less reported in study group, while no difference was observed in other sex-related dimensions. Vaginal extension does not worsen pelvic floor symptoms. Sexual rehabilitation interventions are of significance and should be paid more attention to the CCSs in China. © 2014 International Society for Sexual Medicine.

Collision cross section measurements for biomolecules within a high-resolution FT-ICR cell: theory.

PubMed

Guo, Dan; Xin, Yi; Li, Dayu; Xu, Wei

2015-04-14

In this study, an energetic hard-sphere ion-neutral collision model was proposed to bridge-link ion collision cross section (CCS) with the image current collected from a high-resolution Fourier transform ion cyclotron resonance (FT-ICR) cell. By investigating the nonlinear effects induced by high-order electric fields and image charge forces, the energetic hard-sphere collision model was validated through experiments. Suitable application regions for the energetic hard-sphere collision model, as well as for the conventional Langevin and hard-sphere collision models, were also discussed. The energetic hard-sphere collision model was applied in the extraction of ion CCSs from high-resolution FT-ICR mass spectra. Discussions in the present study also apply to FT-Orbitraps and FT-quadrupole ion traps.

Fractional reactive extraction for symmetrical separation of 4-nitro-D,L-phenylalanine in centrifugal contactor separators: experiments and modeling.

PubMed

Tang, Kewen; Wen, Ping; Zhang, Panliang; Huang, Yan

2015-01-01

The enantioselective liquid-liquid extraction of 4-nitro-D,L-phenylalanine (D,L-Nphy) using PdCl2 {(s)-BINAP} as extractant in dichloroethane was studied experimentally in a countercurrent cascade of 10 centrifugal contactor separators (CCSs) at 5°C, involving flow ratio, extractant concentration, and Cl(-) concentration. The steady-state enantiomeric excess (ee) in both stream exits was 90.86% at a 93.29% yield. The predicted value was modeled using an equilibrium stage approach. The correlation between model and experiment was satisfactory. The model was applied to optimize the production of both enantiomers in >97% ee and >99% ee. 14 stages and 16 stages are required for 97% ee and 99% ee for both enantiomers, respectively. © 2014 Wiley Periodicals, Inc.

Asymmetric distribution of convection in tropical cyclones over the western North Pacific Ocean

NASA Astrophysics Data System (ADS)

Yang, Lu; Fei, Jianfang; Huang, Xiaogang; Cheng, Xiaoping; Yang, Xiangrong; Ding, Juli; Shi, Wenli

2016-11-01

Forecasts of the intensity and quantitative precipitation of tropical cyclones (TCs) are generally inaccurate, because the strength and structure of a TC show a complicated spatiotemporal pattern and are affected by various factors. Among these, asymmetric convection plays an important role. This study investigates the asymmetric distribution of convection in TCs over the western North Pacific during the period 2005-2012, based on data obtained from the Feng Yun 2 (FY2) geostationary satellite. The asymmetric distributions of the incidence, intensity and morphology of convections are analyzed. Results show that the PDFs of the convection occurrence curve to the azimuth are sinusoidal. The rear-left quadrant relative to TC motion shows the highest occurrence rate of convection, while the front-right quadrant has the lowest. In terms of intensity, weak convections are favored in the front-left of a TC at large distances, whereas strong convections are more likely to appear to the rear-right of a TC within a 300 km range. More than 70% of all MCSs examined here are elongated systems, and meso- β enlongated convective systems (M βECSs) are the most dominant type observed in the outer region of a TC. Smaller MCSs tend to be more concentrated near the center of a TC. While semi-circular MCSs [M βCCSs, MCCs (mesoscale convective complexes)] show a high incidence rate to the rear of a TC, elongated MCSs [M βECSs, PECSs (persistent elongated convective systems)] are more likely to appear in the rear-right quadrant of a TC within a range of 400 km.

Infertility, infertility treatment, and achievement of pregnancy in female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort

PubMed Central

Barton, Sara E.; Najita, Julie S.; Ginsburg, Elizabeth S.; Leisenring, Wendy M.; Stovall, Marilyn; Weathers, Rita E.; Sklar, Charles A.; Robison, Leslie L.; Diller, Lisa

2013-01-01

Background Prior studies have documented decreased pregnancy rates and early menopause in female cancer survivors; however, infertility rates and reproductive interventions have not been studied. This study investigates infertility and time to pregnancy among female childhood cancer survivors, and analyzes treatment characteristics associated with infertility and subsequent pregnancy. Methods The Childhood Cancer Survivor Study (CCSS) is a cohort study including five-year cancer survivors from 26 institutions who were <21 years old at the time of diagnosis between January 1, 1970, and December 31, 1986, and a sibling control group. CCSS females ages 18–39 years reporting they had ever been sexually active (3,531 survivors and 1,366 female controls) were studied. Self-reported infertility, medical treatment for infertility, the time to first pregnancy in survivors and siblings, and the risk of infertility in survivors by demographic, disease, and treatment variables were analyzed. Findings Survivors had an increased risk of clinical infertility (>1 year of attempts at conception without success) compared to siblings which was most pronounced at early reproductive ages (≤24 years Relative Risk (RR)=2·92, 95% Confidence Interval (CI) 1·18–7·20; 25–29 years RR=1·61, 95% CI 1·05–2·48; 30–39 years RR=1·37, 95% CI 1·11–1·69). Despite being equally likely to seek treatment for infertility, survivors were less likely to be prescribed medication for treatment of infertility (RR=0·57, 95% CI 0·46–0·70). Increasing doses of uterine radiation and alkylating agent chemotherapy were most strongly associated with infertility. Although survivors had an increased time to pregnancy interval (p=0·032), 64·2% (292/455) with infertility achieved a pregnancy. Interpretation A more comprehensive understanding of infertility after cancer is critical for counseling and decision-making regarding future attempts at conception as well as fertility preservation. PMID:23856401

Functional brain networks in Alzheimer's disease: EEG analysis based on limited penetrable visibility graph and phase space method

NASA Astrophysics Data System (ADS)

Wang, Jiang; Yang, Chen; Wang, Ruofan; Yu, Haitao; Cao, Yibin; Liu, Jing

2016-10-01

In this paper, EEG series are applied to construct functional connections with the correlation between different regions in order to investigate the nonlinear characteristic and the cognitive function of the brain with Alzheimer's disease (AD). First, limited penetrable visibility graph (LPVG) and phase space method map single EEG series into networks, and investigate the underlying chaotic system dynamics of AD brain. Topological properties of the networks are extracted, such as average path length and clustering coefficient. It is found that the network topology of AD in several local brain regions are different from that of the control group with no statistically significant difference existing all over the brain. Furthermore, in order to detect the abnormality of AD brain as a whole, functional connections among different brain regions are reconstructed based on similarity of clustering coefficient sequence (CCSS) of EEG series in the four frequency bands (delta, theta, alpha, and beta), which exhibit obvious small-world properties. Graph analysis demonstrates that for both methodologies, the functional connections between regions of AD brain decrease, particularly in the alpha frequency band. AD causes the graph index complexity of the functional network decreased, the small-world properties weakened, and the vulnerability increased. The obtained results show that the brain functional network constructed by LPVG and phase space method might be more effective to distinguish AD from the normal control than the analysis of single series, which is helpful for revealing the underlying pathological mechanism of the disease.

Effects of cryogenic thermal cycle and immersion on the mechanical characteristics of phenol-resin bonded plywood

NASA Astrophysics Data System (ADS)

Kim, Jeong-Hyeon; Park, Doo-Hwan; Lee, Chi-Seung; Park, Kwang-Jun; Lee, Jae-Myung

2015-12-01

The main objective of the present study is to investigate the performance degradation of the plywood used in a liquefied natural gas (LNG) cargo containment system (CCS). A plywood sheet features an odd number of thinly layered wooden plies bonded perpendicularly to the previous layer to give it a very strong and durable structure. Owing to this strong point, plywood is applied to a variety of interior and exterior applications. Above all, it is widely adopted as insulation panels in an LNG CCS owing to a high stiffness with low density and its superior mechanical capabilities. As an insulation material of an LNG CCS, plywood is constantly exposed to repeated wave-induced thermal variations caused by the loading (-163 °C) and unloading (20 °C) of LNG during general operating periods of 25 years on average. Therefore, the effects of cryogenic-level thermal loads on the material characteristics of plywood must be analyzed with respect to the design and safety aspects of LNG CCSs. In the present study, the influences of the estimated thermal load, testing temperature, and grain orientation on plywood adopted in an LNG CCS are investigated. In terms of safety and design, the repeated thermal loads in a LNG CCS must be considered because the modulus of elasticity (MOE), tensile strength (TS), and modulus of rupture (MOR) are degraded by thermal treatments, such as cyclic thermal-shock and cryogenic immersion.

Extracting biomolecule collision cross sections from the high-resolution FT-ICR mass spectral linewidths.

PubMed

Jiang, Ting; Chen, Yu; Mao, Lu; Marshall, Alan G; Xu, Wei

2016-01-14

It is known that the ion collision cross section (CCS) may be calculated from the linewidth of a Fourier transform ion cyclotron resonance (FT-ICR) mass spectral peak at elevated pressure (e.g., ∼10(-6) Torr). However, the high mass resolution of FT-ICR is sacrificed in those experiments due to high buffer gas pressure. In this study, we describe a linewidth correction method to eliminate the windowing-induced peak broadening effect. Together with the energetic ion-neutral collision model previously developed by our group, this method enables the extraction of CCSs of biomolecules from high-resolution FT-ICR mass spectral linewidths, obtained at a typical operating buffer gas pressure of modern FT-ICR instruments (∼10(-10) Torr). CCS values of peptides including MRFA, angiotensin I, and bradykinin measured by the proposed method agree well with ion mobility measurements, and the unfolding of protein ions (ubiquitin) at higher charge states is also observed.

Radiological dosimetry measurements in Costa Rica

DOE Office of Scientific and Technical Information (OSTI.GOV)

León, M., E-mail: mauisoiso@gmail.com; Santos, F., E-mail: fsantosg@gmail.com

The main cause of human exposure to artificial radiation corresponds to medical applications, so it is essential to reduce the dose to patients, workers and consequently the entire population [1]. Although there is no dose limit for patients, is necessary to reduce it to a minimum possible while still getting all the necessary diagnostic information, taking economic and social factors into account [2]. Based on this proposal, agencies such as the International Atomic Energy Agency has been dedicated to providing guidelines levels, whose function is to serve as standards for the optimization of the medical exposure [3]. This research wasmore » created as a preliminary survey with the claim of eventually determine the guidance levels in Costa Rica for three different studies of general radiology: Lumbar Spine-AP, Chest - PA and Thoracic Spine - AP (for screens with speeds of 400 and 800), and cranio-caudal study in mammography, applied to Costa Rica’s adult population, perform properly in the institutions of Caja Costarricense del Seguro Social (CCSS).« less

Collision Cross Sections and Ion Mobility Separation of Fragment Ions from Complex N-Glycans.

PubMed

Harvey, David J; Watanabe, Yasunori; Allen, Joel D; Rudd, Pauline; Pagel, Kevin; Crispin, Max; Struwe, Weston B

2018-06-01

Ion mobility mass spectrometry (IM-MS) holds great potential for structural glycobiology, in particular in its ability to resolve glycan isomers. Generally, IM-MS has largely been applied to intact glycoconjugate ions with reports focusing on the separation of different adduct types. Here, we explore IM separation and report the collision cross section (CCS) of complex type N-glycans and their fragments in negative ion mode following collision-induced dissociation (CID). CCSs of isomeric fragment ions were found, in some cases, to reveal structural details that were not present in CID spectra themselves. Many fragment ions were confirmed as possessing multiple structure, details of which could be obtained by comparing their drift time profiles to different glycans. By using fragmentation both before and after mobility separation, information was gathered on the fragmentation pathways producing some of the ions. These results help demonstrate the utility of IM and will contribute to the growing use of IM-MS for glycomics. Graphical Abstract ᅟ.

Collision Cross Sections and Ion Mobility Separation of Fragment Ions from Complex N-Glycans

NASA Astrophysics Data System (ADS)

Harvey, David J.; Watanabe, Yasunori; Allen, Joel D.; Rudd, Pauline; Pagel, Kevin; Crispin, Max; Struwe, Weston B.

2018-04-01

Ion mobility mass spectrometry (IM-MS) holds great potential for structural glycobiology, in particular in its ability to resolve glycan isomers. Generally, IM-MS has largely been applied to intact glycoconjugate ions with reports focusing on the separation of different adduct types. Here, we explore IM separation and report the collision cross section (CCS) of complex type N-glycans and their fragments in negative ion mode following collision-induced dissociation (CID). CCSs of isomeric fragment ions were found, in some cases, to reveal structural details that were not present in CID spectra themselves. Many fragment ions were confirmed as possessing multiple structure, details of which could be obtained by comparing their drift time profiles to different glycans. By using fragmentation both before and after mobility separation, information was gathered on the fragmentation pathways producing some of the ions. These results help demonstrate the utility of IM and will contribute to the growing use of IM-MS for glycomics. [Figure not available: see fulltext.

Automated flaw detection scheme for cast austenitic stainless steel weld specimens using Hilbert-Huang transform of ultrasonic phased array data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, Tariq; Majumdar, Shantanu; Udpa, Lalita

2012-05-17

The objective of this work is to develop processing algorithms to detect and localize flaws using ultrasonic phased-array data. Data was collected on cast austenitic stainless stell (CASS) weld specimens onloan from the U.S. nuclear power industry' Pressurized Walter Reactor Owners Group (PWROG) traveling specimen set. Each specimen consists of a centrifugally cast stainless stell (CCSS) pipe section welded to a statically cst(SCSS) or wrought (WRSS) section. The paper presents a novel automated flaw detection and localization scheme using low frequency ultrasonic phased array inspection singals from the weld and heat affected zone of the based materials. The major stepsmore » of the overall scheme are preprocessing and region of interest (ROI) detection followed by the Hilbert-Huang transform (HHT) of A-scans in the detected ROIs. HHT offers time-frequency-energy distribution for each ROI. The Accumulation of energy in a particular frequency band is used as a classification feature for the particular ROI.« less

Radiological dosimetry measurements in Costa Rica

NASA Astrophysics Data System (ADS)

León, M.; Santos, F.

2016-07-01

The main cause of human exposure to artificial radiation corresponds to medical applications, so it is essential to reduce the dose to patients, workers and consequently the entire population [1]. Although there is no dose limit for patients, is necessary to reduce it to a minimum possible while still getting all the necessary diagnostic information, taking economic and social factors into account [2]. Based on this proposal, agencies such as the International Atomic Energy Agency has been dedicated to providing guidelines levels, whose function is to serve as standards for the optimization of the medical exposure [3]. This research was created as a preliminary survey with the claim of eventually determine the guidance levels in Costa Rica for three different studies of general radiology: Lumbar Spine-AP, Chest - PA and Thoracic Spine - AP (for screens with speeds of 400 and 800), and cranio-caudal study in mammography, applied to Costa Rica's adult population, perform properly in the institutions of Caja Costarricense del Seguro Social (CCSS).

Comparative study of novel versus conventional two-wavelength spectrophotometric methods for analysis of spectrally overlapping binary mixture.

PubMed

Lotfy, Hayam M; Hegazy, Maha A; Rezk, Mamdouh R; Omran, Yasmin Rostom

2015-09-05

Smart spectrophotometric methods have been applied and validated for the simultaneous determination of a binary mixture of chloramphenicol (CPL) and prednisolone acetate (PA) without preliminary separation. Two novel methods have been developed; the first method depends upon advanced absorbance subtraction (AAS), while the other method relies on advanced amplitude modulation (AAM); in addition to the well established dual wavelength (DW), ratio difference (RD) and constant center coupled with spectrum subtraction (CC-SS) methods. Accuracy, precision and linearity ranges of these methods were determined. Moreover, selectivity was assessed by analyzing synthetic mixtures of both drugs. The proposed methods were successfully applied to the assay of drugs in their pharmaceutical formulations. No interference was observed from common additives and the validity of the methods was tested. The obtained results have been statistically compared to that of official spectrophotometric methods to give a conclusion that there is no significant difference between the proposed methods and the official ones with respect to accuracy and precision. Copyright © 2015 Elsevier B.V. All rights reserved.

A Joyful Noise: The Vocal Health of Worship Leaders and Contemporary Christian Singers.

PubMed

Neto, Leon; Meyer, David

2017-03-01

Contemporary commercial music (CCM) is a term that encompasses many styles of music. A growing subset of CCM is contemporary Christian music, a genre that has outpaced other popular styles such as Latin, jazz, and classical music. Contemporary Christian singers (CCSs) and worship leaders (WLs) are a subset of CCM musicians that face unique vocal demands and risks. They typically lack professional training and often perform in acoustically disadvantageous venues with substandard sound reinforcement systems. The vocal needs and risks of these singers are not well understood, and because of this, their training and care may be suboptimal. The aim of the present study was to investigate the vocal health of this growing population and their awareness of standard vocal hygiene principles. An online questionnaire was designed and administered to participants in the Americas, Europe, Australia, and Asia. A total of 614 participants responded to the questionnaire, which is made available in English, Portuguese, and Spanish. Many participants reported vocal symptoms such as vocal fatigue (n = 213; 34.7%), tickling or choking sensation (n = 149; 24.3%), loss of upper range (n = 172; 28%), and complete loss of voice (n = 25; 4.1%). One third of the participants (n = 210; 34%) indicated that they do not warm up their voices before performances and over half of the participants (n = 319; 52%) have no formal vocal training. Results suggest that this population demonstrates low awareness of vocal hygiene principles, frequently experience difficulty with their voices, and may face elevated risk of vocal pathology. Future studies of this population may confirm the vocal risks that our preliminary findings suggest. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Teaching Outside the Box: Challenging Gifted Students with Polar Sciences Without Benefit of a Science Classroom

NASA Astrophysics Data System (ADS)

Dooley, J.

2013-12-01

In the high-stakes-testing world of one-size-fits-most educational practices, it is often the needs of the most able students that are unmet, yet these high ability learners can benefit greatly from exploration in the area of polar science. With school schedules and budgets already stretched to the breaking point and Common Core (CCSS) subjects are the focus, very few resources remain for topics considered by some as unimportant. Polar and climate science are prime examples. Here, a council member of Polar Educators International and Gifted Education Teacher, shares resources and ideas to engage this unique group of students and others. She draws from experiences and knowledge gained through ANDRILL's Arise Educator program, IPY Oslo and Montreal PolarEDUCATOR workshops, and Consortium for Ocean Leadership's Deep Earth Academy. Topics include School-wide Enrichment through use of ANDRILL's Flexhibit material and participation in Antarctica Day, afterschool Deep Freeze clubs that presented in public outreach venues for polar science events at the Maryland Science Center in Baltimore and NYC's Museum of Natural History, group project work using IODP core data from Antarctica, interaction with polar scientists via Skype, and other projects.

Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS.

PubMed

Devine, Paul W A; Fisher, Henry C; Calabrese, Antonio N; Whelan, Fiona; Higazi, Daniel R; Potts, Jennifer R; Lowe, David C; Radford, Sheena E; Ashcroft, Alison E

2017-09-01

Collision cross-section (CCS) measurements obtained from ion mobility spectrometry-mass spectrometry (IMS-MS) analyses often provide useful information concerning a protein's size and shape and can be complemented by modeling procedures. However, there have been some concerns about the extent to which certain proteins maintain a native-like conformation during the gas-phase analysis, especially proteins with dynamic or extended regions. Here we have measured the CCSs of a range of biomolecules including non-globular proteins and RNAs of different sequence, size, and stability. Using traveling wave IMS-MS, we show that for the proteins studied, the measured CCS deviates significantly from predicted CCS values based upon currently available structures. The results presented indicate that these proteins collapse to different extents varying on their elongated structures upon transition into the gas-phase. Comparing two RNAs of similar mass but different solution structures, we show that these biomolecules may also be susceptible to gas-phase compaction. Together, the results suggest that caution is needed when predicting structural models based on CCS data for RNAs as well as proteins with non-globular folds. Graphical Abstract ᅟ.

Early Numeracy Assessment: The Development of the Preschool Numeracy Scales

PubMed Central

Purpura, David J.; Lonigan, Christopher J.

2015-01-01

Research Findings The focus of this study was to construct and validate twelve brief early numeracy assessment tasks that measure the skills and concepts identified as key to early mathematics development by the National Council of Teachers of Mathematics (2006) and the National Mathematics Advisory Panel (2008)—as well as critical developmental precursors to later mathematics skill by the Common Core State Standards (CCSS; 2010). Participants were 393 preschool children ages 3 to 5 years old. Measure development and validation occurred through three analytic phases designed to ensure that the measures were brief, reliable, and valid. These measures included: one-to-one counting, cardinality, counting subsets, subitizing, number comparison, set comparison, number order, numeral identification, set-to-numerals, story problems, number combinations, and verbal counting. Practice or Policy Teachers have extensive demands on their time, yet, they are tasked with ensuring that all students’ academic needs are met. To identify individual instructional needs and measure progress, they need to be able to efficiently assess children’s numeracy skills. The measures developed in this study are not only reliable and valid, but also easy to use and can be utilized for measuring the effects of targeted instruction on individual numeracy skills. PMID:25709375

Real time digital propulsion system simulation for manned flight simulators

NASA Technical Reports Server (NTRS)

Mihaloew, J. R.; Hart, C. E.

1978-01-01

A real time digital simulation of a STOL propulsion system was developed which generates significant dynamics and internal variables needed to evaluate system performance and aircraft interactions using manned flight simulators. The simulation ran at a real-to-execution time ratio of 8.8. The model was used in a piloted NASA flight simulator program to evaluate the simulation technique and the propulsion system digital control. The simulation is described and results shown. Limited results of the flight simulation program are also presented.

Warriors Edge Simulation and Gaming System: The Squad Simulation

DTIC Science & Technology

2005-08-01

Warriors Edge Simulation and Gaming System: The Squad Simulation by Mark Thomas and Gary Moss ARL-TR-3564 August 2005...Edge Simulation and Gaming System: The Squad Simulation Mark Thomas and Gary Moss Computational and Information Sciences Directorate, ARL...2004–30 September 2004 5a. CONTRACT NUMBER 5b. GRANT NUMBER 4. TITLE AND SUBTITLE Warriors Edge Simulation and Gaming System: The Squad

Expert systems and simulation models; Proceedings of the Seminar, Tucson, AZ, November 18, 19, 1985

NASA Technical Reports Server (NTRS)

1986-01-01

The seminar presents papers on modeling and simulation methodology, artificial intelligence and expert systems, environments for simulation/expert system development, and methodology for simulation/expert system development. Particular attention is given to simulation modeling concepts and their representation, modular hierarchical model specification, knowledge representation, and rule-based diagnostic expert system development. Other topics include the combination of symbolic and discrete event simulation, real time inferencing, and the management of large knowledge-based simulation projects.

Construction of multi-functional open modulized Matlab simulation toolbox for imaging ladar system

NASA Astrophysics Data System (ADS)

Wu, Long; Zhao, Yuan; Tang, Meng; He, Jiang; Zhang, Yong

2011-06-01

Ladar system simulation is to simulate the ladar models using computer simulation technology in order to predict the performance of the ladar system. This paper presents the developments of laser imaging radar simulation for domestic and overseas studies and the studies of computer simulation on ladar system with different application requests. The LadarSim and FOI-LadarSIM simulation facilities of Utah State University and Swedish Defence Research Agency are introduced in details. This paper presents the low level of simulation scale, un-unified design and applications of domestic researches in imaging ladar system simulation, which are mostly to achieve simple function simulation based on ranging equations for ladar systems. Design of laser imaging radar simulation with open and modularized structure is proposed to design unified modules for ladar system, laser emitter, atmosphere models, target models, signal receiver, parameters setting and system controller. Unified Matlab toolbox and standard control modules have been built with regulated input and output of the functions, and the communication protocols between hardware modules. A simulation based on ICCD gain-modulated imaging ladar system for a space shuttle is made based on the toolbox. The simulation result shows that the models and parameter settings of the Matlab toolbox are able to simulate the actual detection process precisely. The unified control module and pre-defined parameter settings simplify the simulation of imaging ladar detection. Its open structures enable the toolbox to be modified for specialized requests. The modulization gives simulations flexibility.

The role of the research simulator in the systems development of rotorcraft

NASA Technical Reports Server (NTRS)

Statler, I. C.; Deel, A.

1981-01-01

The potential application of the research simulator to future rotorcraft systems design, development, product improvement evaluations, and safety analysis is examined. Current simulation capabilities for fixed-wing aircraft are reviewed and the requirements of a rotorcraft simulator are defined. The visual system components, vertical motion simulator, cab, and computation system for a research simulator under development are described.

Advanced EMT and Phasor-Domain Hybrid Simulation with Simulation Mode Switching Capability for Transmission and Distribution Systems

DOE PAGES

Huang, Qiuhua; Vittal, Vijay

2018-05-09

Conventional electromagnetic transient (EMT) and phasor-domain hybrid simulation approaches presently exist for trans-mission system level studies. Their simulation efficiency is generally constrained by the EMT simulation. With an increasing number of distributed energy resources and non-conventional loads being installed in distribution systems, it is imperative to extend the hybrid simulation application to include distribution systems and integrated transmission and distribution systems. Meanwhile, it is equally important to improve the simulation efficiency as the modeling scope and complexity of the detailed system in the EMT simulation increases. To meet both requirements, this paper introduces an advanced EMT and phasor-domain hybrid simulationmore » approach. This approach has two main features: 1) a comprehensive phasor-domain modeling framework which supports positive-sequence, three-sequence, three-phase and mixed three-sequence/three-phase representations and 2) a robust and flexible simulation mode switching scheme. The developed scheme enables simulation switching from hybrid simulation mode back to pure phasor-domain dynamic simulation mode to achieve significantly improved simulation efficiency. The proposed method has been tested on integrated transmission and distribution systems. In conclusion, the results show that with the developed simulation switching feature, the total computational time is significantly reduced compared to running the hybrid simulation for the whole simulation period, while maintaining good simulation accuracy.« less

Advanced EMT and Phasor-Domain Hybrid Simulation with Simulation Mode Switching Capability for Transmission and Distribution Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Qiuhua; Vittal, Vijay

Conventional electromagnetic transient (EMT) and phasor-domain hybrid simulation approaches presently exist for trans-mission system level studies. Their simulation efficiency is generally constrained by the EMT simulation. With an increasing number of distributed energy resources and non-conventional loads being installed in distribution systems, it is imperative to extend the hybrid simulation application to include distribution systems and integrated transmission and distribution systems. Meanwhile, it is equally important to improve the simulation efficiency as the modeling scope and complexity of the detailed system in the EMT simulation increases. To meet both requirements, this paper introduces an advanced EMT and phasor-domain hybrid simulationmore » approach. This approach has two main features: 1) a comprehensive phasor-domain modeling framework which supports positive-sequence, three-sequence, three-phase and mixed three-sequence/three-phase representations and 2) a robust and flexible simulation mode switching scheme. The developed scheme enables simulation switching from hybrid simulation mode back to pure phasor-domain dynamic simulation mode to achieve significantly improved simulation efficiency. The proposed method has been tested on integrated transmission and distribution systems. In conclusion, the results show that with the developed simulation switching feature, the total computational time is significantly reduced compared to running the hybrid simulation for the whole simulation period, while maintaining good simulation accuracy.« less

Development and training of a learning expert system in an autonomous mobile robot via simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spelt, P.F.; Lyness, E.; DeSaussure, G.

1989-11-01

The Center for Engineering Systems Advanced Research (CESAR) conducts basic research in the area of intelligent machines. Recently at CESAR a learning expert system was created to operate on board an autonomous robot working at a process control panel. The authors discuss two-computer simulation system used to create, evaluate and train this learning system. The simulation system has a graphics display of the current status of the process being simulated, and the same program which does the simulating also drives the actual control panel. Simulation results were validated on the actual robot. The speed and safety values of using amore » computerized simulator to train a learning computer, and future uses of the simulation system, are discussed.« less

Workshop on data acquisition and trigger system simulations for high energy physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1992-12-31

This report discusses the following topics: DAQSIM: A data acquisition system simulation tool; Front end and DCC Simulations for the SDC Straw Tube System; Simulation of Non-Blocklng Data Acquisition Architectures; Simulation Studies of the SDC Data Collection Chip; Correlation Studies of the Data Collection Circuit & The Design of a Queue for this Circuit; Fast Data Compression & Transmission from a Silicon Strip Wafer; Simulation of SCI Protocols in Modsim; Visual Design with vVHDL; Stochastic Simulation of Asynchronous Buffers; SDC Trigger Simulations; Trigger Rates, DAQ & Online Processing at the SSC; Planned Enhancements to MODSEM II & SIMOBJECT -- anmore » Overview -- R.; DAGAR -- A synthesis system; Proposed Silicon Compiler for Physics Applications; Timed -- LOTOS in a PROLOG Environment: an Algebraic language for Simulation; Modeling and Simulation of an Event Builder for High Energy Physics Data Acquisition Systems; A Verilog Simulation for the CDF DAQ; Simulation to Design with Verilog; The DZero Data Acquisition System: Model and Measurements; DZero Trigger Level 1.5 Modeling; Strategies Optimizing Data Load in the DZero Triggers; Simulation of the DZero Level 2 Data Acquisition System; A Fast Method for Calculating DZero Level 1 Jet Trigger Properties and Physics Input to DAQ Studies.« less

Research of laser echo signal simulator

NASA Astrophysics Data System (ADS)

Xu, Rui; Shi, Rui; Wang, Xin; Li, Zhou

2015-11-01

Laser echo signal simulator is one of the most significant components of hardware-in-the-loop (HWIL) simulation systems for LADAR. System model and time series model of laser echo signal simulator are established. Some influential factors which could induce fixed error and random error on the simulated return signals are analyzed, and then these system insertion errors are analyzed quantitatively. Using this theoretical model, the simulation system is investigated experimentally. The results corrected by subtracting fixed error indicate that the range error of the simulated laser return signal is less than 0.25m, and the distance range that the system can simulate is from 50m to 20km.

Computational simulation of concurrent engineering for aerospace propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1992-01-01

Results are summarized of an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering. These results demonstrate that development of computational simulations methods for concurrent engineering is timely. Extensive infrastructure, in terms of multi-discipline simulation, component-specific simulation, system simulators, fabrication process simulation, and simulation of uncertainties - fundamental in developing such methods, is available. An approach is recommended which can be used to develop computational simulation methods for concurrent engineering for propulsion systems and systems in general. Benefits and facets needing early attention in the development are outlined.

Computational simulation for concurrent engineering of aerospace propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1993-01-01

Results are summarized for an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering. These results demonstrate that development of computational simulation methods for concurrent engineering is timely. Extensive infrastructure, in terms of multi-discipline simulation, component-specific simulation, system simulators, fabrication process simulation, and simulation of uncertainties--fundamental to develop such methods, is available. An approach is recommended which can be used to develop computational simulation methods for concurrent engineering of propulsion systems and systems in general. Benefits and issues needing early attention in the development are outlined.

Computational simulation for concurrent engineering of aerospace propulsion systems

NASA Astrophysics Data System (ADS)

Chamis, C. C.; Singhal, S. N.

1993-02-01

Results are summarized for an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering. These results demonstrate that development of computational simulation methods for concurrent engineering is timely. Extensive infrastructure, in terms of multi-discipline simulation, component-specific simulation, system simulators, fabrication process simulation, and simulation of uncertainties--fundamental to develop such methods, is available. An approach is recommended which can be used to develop computational simulation methods for concurrent engineering of propulsion systems and systems in general. Benefits and issues needing early attention in the development are outlined.

Durham extremely large telescope adaptive optics simulation platform.

PubMed

Basden, Alastair; Butterley, Timothy; Myers, Richard; Wilson, Richard

2007-03-01

Adaptive optics systems are essential on all large telescopes for which image quality is important. These are complex systems with many design parameters requiring optimization before good performance can be achieved. The simulation of adaptive optics systems is therefore necessary to categorize the expected performance. We describe an adaptive optics simulation platform, developed at Durham University, which can be used to simulate adaptive optics systems on the largest proposed future extremely large telescopes as well as on current systems. This platform is modular, object oriented, and has the benefit of hardware application acceleration that can be used to improve the simulation performance, essential for ensuring that the run time of a given simulation is acceptable. The simulation platform described here can be highly parallelized using parallelization techniques suited for adaptive optics simulation, while still offering the user complete control while the simulation is running. The results from the simulation of a ground layer adaptive optics system are provided as an example to demonstrate the flexibility of this simulation platform.

Automated simulation as part of a design workstation

NASA Technical Reports Server (NTRS)

Cantwell, E.; Shenk, T.; Robinson, P.; Upadhye, R.

1990-01-01

A development project for a design workstation for advanced life-support systems incorporating qualitative simulation, required the implementation of a useful qualitative simulation capability and the integration of qualitative and quantitative simulations, such that simulation capabilities are maximized without duplication. The reason is that to produce design solutions to a system goal, the behavior of the system in both a steady and perturbed state must be represented. The paper reports on the Qualitative Simulation Tool (QST), on an expert-system-like model building and simulation interface toll called ScratchPad (SP), and on the integration of QST and SP with more conventional, commercially available simulation packages now being applied in the evaluation of life-support system processes and components.

Designing a SCADA system simulator for fast breeder reactor

NASA Astrophysics Data System (ADS)

Nugraha, E.; Abdullah, A. G.; Hakim, D. L.

2016-04-01

SCADA (Supervisory Control and Data Acquisition) system simulator is a Human Machine Interface-based software that is able to visualize the process of a plant. This study describes the results of the process of designing a SCADA system simulator that aims to facilitate the operator in monitoring, controlling, handling the alarm, accessing historical data and historical trend in Nuclear Power Plant (NPP) type Fast Breeder Reactor (FBR). This research used simulation to simulate NPP type FBR Kalpakkam in India. This simulator was developed using Wonderware Intouch software 10 and is equipped with main menu, plant overview, area graphics, control display, set point display, alarm system, real-time trending, historical trending and security system. This simulator can properly simulate the principle of energy flow and energy conversion process on NPP type FBR. This SCADA system simulator can be used as training media for NPP type FBR prospective operators.

Space Station communications and tracking systems modeling and RF link simulation

NASA Technical Reports Server (NTRS)

Tsang, Chit-Sang; Chie, Chak M.; Lindsey, William C.

1986-01-01

In this final report, the effort spent on Space Station Communications and Tracking System Modeling and RF Link Simulation is described in detail. The effort is mainly divided into three parts: frequency division multiple access (FDMA) system simulation modeling and software implementation; a study on design and evaluation of a functional computerized RF link simulation/analysis system for Space Station; and a study on design and evaluation of simulation system architecture. This report documents the results of these studies. In addition, a separate User's Manual on Space Communications Simulation System (SCSS) (Version 1) documents the software developed for the Space Station FDMA communications system simulation. The final report, SCSS user's manual, and the software located in the NASA JSC system analysis division's VAX 750 computer together serve as the deliverables from LinCom for this project effort.

An Integrated Modeling and Simulation Methodology for Intelligent Systems Design and Testing

DTIC Science & Technology

2002-08-01

simulation and actual execution. KEYWORDS: Model Continuity, Modeling, Simulation, Experimental Frame, Real Time Systems , Intelligent Systems...the methodology for a stand-alone real time system. Then it will scale up to distributed real time systems . For both systems, step-wise simulation...MODEL CONTINUITY Intelligent real time systems monitor, respond to, or control, an external environment. This environment is connected to the digital

Combining density functional theory (DFT) and collision cross-section (CCS) calculations to analyze the gas-phase behaviour of small molecules and their protonation site isomers.

PubMed

Boschmans, Jasper; Jacobs, Sam; Williams, Jonathan P; Palmer, Martin; Richardson, Keith; Giles, Kevin; Lapthorn, Cris; Herrebout, Wouter A; Lemière, Filip; Sobott, Frank

2016-06-20

Electrospray ion mobility-mass spectrometry (IM-MS) data show that for some small molecules, two (or even more) ions with identical sum formula and mass, but distinct drift times are observed. In spite of showing their own unique and characteristic fragmentation spectra in MS/MS, no configurational or constitutional isomers are found to be present in solution. Instead the observation and separation of such ions appears to be inherent to their gas-phase behaviour during ion mobility experiments. The origin of multiple drift times is thought to be the result of protonation site isomers ('protomers'). Although some important properties of protomers have been highlighted by other studies, correlating the experimental collision cross-sections (CCSs) with calculated values has proven to be a major difficulty. As a model, this study uses the pharmaceutical compound melphalan and a number of related molecules with alternative (gas-phase) protonation sites. Our study combines density functional theory (DFT) calculations with modified MobCal methods (e.g. nitrogen-based Trajectory Method algorithm) for the calculation of theoretical CCS values. Calculated structures can be linked to experimentally observed signals, and a strong correlation is found between the difference of the calculated dipole moments of the protomer pairs and their experimental CCS separation.

Collaborative simulation method with spatiotemporal synchronization process control

NASA Astrophysics Data System (ADS)

Zou, Yisheng; Ding, Guofu; Zhang, Weihua; Zhang, Jian; Qin, Shengfeng; Tan, John Kian

2016-10-01

When designing a complex mechatronics system, such as high speed trains, it is relatively difficult to effectively simulate the entire system's dynamic behaviors because it involves multi-disciplinary subsystems. Currently,a most practical approach for multi-disciplinary simulation is interface based coupling simulation method, but it faces a twofold challenge: spatial and time unsynchronizations among multi-directional coupling simulation of subsystems. A new collaborative simulation method with spatiotemporal synchronization process control is proposed for coupling simulating a given complex mechatronics system across multiple subsystems on different platforms. The method consists of 1) a coupler-based coupling mechanisms to define the interfacing and interaction mechanisms among subsystems, and 2) a simulation process control algorithm to realize the coupling simulation in a spatiotemporal synchronized manner. The test results from a case study show that the proposed method 1) can certainly be used to simulate the sub-systems interactions under different simulation conditions in an engineering system, and 2) effectively supports multi-directional coupling simulation among multi-disciplinary subsystems. This method has been successfully applied in China high speed train design and development processes, demonstrating that it can be applied in a wide range of engineering systems design and simulation with improved efficiency and effectiveness.

Real-time visual simulation of APT system based on RTW and Vega

NASA Astrophysics Data System (ADS)

Xiong, Shuai; Fu, Chengyu; Tang, Tao

2012-10-01

The Matlab/Simulink simulation model of APT (acquisition, pointing and tracking) system is analyzed and established. Then the model's C code which can be used for real-time simulation is generated by RTW (Real-Time Workshop). Practical experiments show, the simulation result of running the C code is the same as running the Simulink model directly in the Matlab environment. MultiGen-Vega is a real-time 3D scene simulation software system. With it and OpenGL, the APT scene simulation platform is developed and used to render and display the virtual scenes of the APT system. To add some necessary graphics effects to the virtual scenes real-time, GLSL (OpenGL Shading Language) shaders are used based on programmable GPU. By calling the C code, the scene simulation platform can adjust the system parameters on-line and get APT system's real-time simulation data to drive the scenes. Practical application shows that this visual simulation platform has high efficiency, low charge and good simulation effect.

Development of the KOSMS management simulation training system and its application

NASA Astrophysics Data System (ADS)

Takatsu, Yoshiki

The use of games which simulate actual corporate management has recently become more common and is now utilized in various ways for in-house corporate training courses. KOSMS (Kobe Steel Management Simulation System), a training system designed to help improve the management skills of senior management staff, is a unique management simulation training system in which the participants, using personal computers, must make decisions concerning a variety of management activities, in simulated competition with other corporations. This report outlines the KOSMS system, and describes the basic structure and detailed contents of the management simulation models, and actual application of the KOSMS management simulation training.

Intermediate Fidelity Closed Brayton Cycle Power Conversion Model

NASA Technical Reports Server (NTRS)

Lavelle, Thomas M.; Khandelwal, Suresh; Owen, Albert K.

2006-01-01

This paper describes the implementation of an intermediate fidelity model of a closed Brayton Cycle power conversion system (Closed Cycle System Simulation). The simulation is developed within the Numerical Propulsion Simulation System architecture using component elements from earlier models. Of particular interest, and power, is the ability of this new simulation system to initiate a more detailed analysis of compressor and turbine components automatically and to incorporate the overall results into the general system simulation.

A real time Pegasus propulsion system model for VSTOL piloted simulation evaluation

NASA Technical Reports Server (NTRS)

Mihaloew, J. R.; Roth, S. P.; Creekmore, R.

1981-01-01

A real time propulsion system modeling technique suitable for use in man-in-the-loop simulator studies was developd. This technique provides the system accuracy, stability, and transient response required for integrated aircraft and propulsion control system studies. A Pegasus-Harrier propulsion system was selected as a baseline for developing mathematical modeling and simulation techniques for VSTOL. Initially, static and dynamic propulsion system characteristics were modeled in detail to form a nonlinear aerothermodynamic digital computer simulation of a Pegasus engine. From this high fidelity simulation, a real time propulsion model was formulated by applying a piece-wise linear state variable methodology. A hydromechanical and water injection control system was also simulated. The real time dynamic model includes the detail and flexibility required for the evaluation of critical control parameters and propulsion component limits over a limited flight envelope. The model was programmed for interfacing with a Harrier aircraft simulation. Typical propulsion system simulation results are presented.

Simulation Framework for Intelligent Transportation Systems

DOT National Transportation Integrated Search

1996-10-01

A simulation framework has been developed for a large-scale, comprehensive, scaleable simulation of an Intelligent Transportation System. The simulator is designed for running on parellel computers and distributed (networked) computer systems, but ca...

Automated simulation as part of a design workstation

NASA Technical Reports Server (NTRS)

Cantwell, Elizabeth; Shenk, T.; Robinson, P.; Upadhye, R.

1990-01-01

A development project for a design workstation for advanced life-support systems (called the DAWN Project, for Design Assistant Workstation), incorporating qualitative simulation, required the implementation of a useful qualitative simulation capability and the integration of qualitative and quantitative simulation such that simulation capabilities are maximized without duplication. The reason is that to produce design solutions to a system goal, the behavior of the system in both a steady and perturbed state must be represented. The Qualitative Simulation Tool (QST), on an expert-system-like model building and simulation interface toll called ScratchPad (SP), and on the integration of QST and SP with more conventional, commercially available simulation packages now being applied in the evaluation of life-support system processes and components are discussed.

Research on an expert system for database operation of simulation-emulation math models. Volume 1, Phase 1: Results

NASA Technical Reports Server (NTRS)

Kawamura, K.; Beale, G. O.; Schaffer, J. D.; Hsieh, B. J.; Padalkar, S.; Rodriguez-Moscoso, J. J.

1985-01-01

The results of the first phase of Research on an Expert System for Database Operation of Simulation/Emulation Math Models, is described. Techniques from artificial intelligence (AI) were to bear on task domains of interest to NASA Marshall Space Flight Center. One such domain is simulation of spacecraft attitude control systems. Two related software systems were developed to and delivered to NASA. One was a generic simulation model for spacecraft attitude control, written in FORTRAN. The second was an expert system which understands the usage of a class of spacecraft attitude control simulation software and can assist the user in running the software. This NASA Expert Simulation System (NESS), written in LISP, contains general knowledge about digital simulation, specific knowledge about the simulation software, and self knowledge.

Concept verification of three dimensional free motion simulator for space robot

NASA Technical Reports Server (NTRS)

Okamoto, Osamu; Nakaya, Teruomi; Pokines, Brett

1994-01-01

In the development of automatic assembling technologies for space structures, it is an indispensable matter to investigate and simulate the movements of robot satellites concerned with mission operation. The movement investigation and simulation on the ground will be effectively realized by a free motion simulator. Various types of ground systems for simulating free motion have been proposed and utilized. Some of these methods are a neutral buoyancy system, an air or magnetic suspension system, a passive suspension balance system, and a free flying aircraft or drop tower system. In addition, systems can be simulated by computers using an analytical model. Each free motion simulation method has limitations and well known problems, specifically, disturbance by water viscosity, limited number of degrees-of-freedom, complex dynamics induced by the attachment of the simulation system, short experiment time, and the lack of high speed super-computer simulation systems, respectively. The basic idea presented here is to realize 3-dimensional free motion. This is achieved by combining a spherical air bearing, a cylindrical air bearing, and a flat air bearing. A conventional air bearing system has difficulty realizing free vertical motion suspension. The idea of free vertical suspension is that a cylindrical air bearing and counter balance weight realize vertical free motion. This paper presents a design concept, configuration, and basic performance characteristics of an innovative free motion simulator. A prototype simulator verifies the feasibility of 3-dimensional free motion simulation.

Development of an Intelligent Monitoring and Control System for a Heterogeneous Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Afjeh, Abdollah A.; Lewandowski, Henry; Homer, Patrick T.; Schlichting, Richard D.

1996-01-01

The NASA Numerical Propulsion System Simulation (NPSS) project is exploring the use of computer simulation to facilitate the design of new jet engines. Several key issues raised in this research are being examined in an NPSS-related research project: zooming, monitoring and control, and support for heterogeneity. The design of a simulation executive that addresses each of these issues is described. In this work, the strategy of zooming, which allows codes that model at different levels of fidelity to be integrated within a single simulation, is applied to the fan component of a turbofan propulsion system. A prototype monitoring and control system has been designed for this simulation to support experimentation with expert system techniques for active control of the simulation. An interconnection system provides a transparent means of connecting the heterogeneous systems that comprise the prototype.

21 CFR 892.5840 - Radiation therapy simulation system.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Radiation therapy simulation system. 892.5840... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5840 Radiation therapy simulation system. (a) Identification. A radiation therapy simulation system is a fluoroscopic or radiographic x-ray...

21 CFR 892.5840 - Radiation therapy simulation system.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Radiation therapy simulation system. 892.5840... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5840 Radiation therapy simulation system. (a) Identification. A radiation therapy simulation system is a fluoroscopic or radiographic x-ray...

Threat radar system simulations

NASA Astrophysics Data System (ADS)

Miller, L.

The capabilities, requirements, and goals of radar emitter simulators are discussed. Simulators are used to evaluate competing receiver designs, to quantify the performance envelope of a radar system, and to model the characteristics of a transmitted signal waveform. A database of candidate threat systems is developed and, in concert with intelligence data on a given weapons system, permits upgrading simulators to new projected threat capabilities. Four currently available simulation techniques are summarized, noting the usefulness of developing modular software for fast controlled-cost upgrades of simulation capabilities.

A Low Cost Microcomputer System for Process Dynamics and Control Simulations.

ERIC Educational Resources Information Center

Crowl, D. A.; Durisin, M. J.

1983-01-01

Discusses a video simulator microcomputer system used to provide real-time demonstrations to strengthen students' understanding of process dynamics and control. Also discusses hardware/software and simulations developed using the system. The four simulations model various configurations of a process liquid level tank system. (JN)

Simulation validation of the XV-15 tilt-rotor research aircraft

NASA Technical Reports Server (NTRS)

Ferguson, S. W.; Hanson, G. D.; Churchill, G. B.

1984-01-01

The results of a simulation validation program of the XV-15 tilt-rotor research aircraft are detailed, covering such simulation aspects as the mathematical model, visual system, motion system, cab aural system, cab control loader system, pilot perceptual fidelity, and generic tilt rotor applications. Simulation validation was performed for the hover, low-speed, and sideward flight modes, with consideration of the in-ground rotor effect. Several deficiencies of the mathematical model and the simulation systems were identified in the course of the simulation validation project, and some were corrected. It is noted that NASA's Vertical Motion Simulator used in the program is an excellent tool for tilt-rotor and rotorcraft design, development, and pilot training.

Method for simulating discontinuous physical systems

DOEpatents

Baty, Roy S.; Vaughn, Mark R.

2001-01-01

The mathematical foundations of conventional numerical simulation of physical systems provide no consistent description of the behavior of such systems when subjected to discontinuous physical influences. As a result, the numerical simulation of such problems requires ad hoc encoding of specific experimental results in order to address the behavior of such discontinuous physical systems. In the present invention, these foundations are replaced by a new combination of generalized function theory and nonstandard analysis. The result is a class of new approaches to the numerical simulation of physical systems which allows the accurate and well-behaved simulation of discontinuous and other difficult physical systems, as well as simpler physical systems. Applications of this new class of numerical simulation techniques to process control, robotics, and apparatus design are outlined.

Research and realization of key technology in HILS interactive system

NASA Astrophysics Data System (ADS)

Liu, Che; Lu, Huiming; Wang, Fankai

2018-03-01

This paper designed HILS (Hardware In the Loop Simulation) interactive system based on xPC platform . Through the interface between C++ and MATLAB engine, establish the seamless data connection between Simulink and interactive system, complete data interaction between system and Simulink, realize the function development of model configuration, parameter modification and off line simulation. We establish the data communication between host and target machine through TCP/IP protocol to realize the model download and real-time simulation. Use database to store simulation data, implement real-time simulation monitoring and simulation data management. Realize system function integration by Qt graphic interface library and dynamic link library. At last, take the typical control system as an example to verify the feasibility of HILS interactive system.

Interactive Web-based Floodplain Simulation System for Realistic Experiments of Flooding and Flood Damage

NASA Astrophysics Data System (ADS)

Demir, I.

2013-12-01

Recent developments in web technologies make it easy to manage and visualize large data sets with general public. Novel visualization techniques and dynamic user interfaces allow users to create realistic environments, and interact with data to gain insight from simulations and environmental observations. The floodplain simulation system is a web-based 3D interactive flood simulation environment to create real world flooding scenarios. The simulation systems provides a visually striking platform with realistic terrain information, and water simulation. Students can create and modify predefined scenarios, control environmental parameters, and evaluate flood mitigation techniques. The web-based simulation system provides an environment to children and adults learn about the flooding, flood damage, and effects of development and human activity in the floodplain. The system provides various scenarios customized to fit the age and education level of the users. This presentation provides an overview of the web-based flood simulation system, and demonstrates the capabilities of the system for various flooding and land use scenarios.

Novel high-fidelity realistic explosion damage simulation for urban environments

NASA Astrophysics Data System (ADS)

Liu, Xiaoqing; Yadegar, Jacob; Zhu, Youding; Raju, Chaitanya; Bhagavathula, Jaya

2010-04-01

Realistic building damage simulation has a significant impact in modern modeling and simulation systems especially in diverse panoply of military and civil applications where these simulation systems are widely used for personnel training, critical mission planning, disaster management, etc. Realistic building damage simulation should incorporate accurate physics-based explosion models, rubble generation, rubble flyout, and interactions between flying rubble and their surrounding entities. However, none of the existing building damage simulation systems sufficiently faithfully realize the criteria of realism required for effective military applications. In this paper, we present a novel physics-based high-fidelity and runtime efficient explosion simulation system to realistically simulate destruction to buildings. In the proposed system, a family of novel blast models is applied to accurately and realistically simulate explosions based on static and/or dynamic detonation conditions. The system also takes account of rubble pile formation and applies a generic and scalable multi-component based object representation to describe scene entities and highly scalable agent-subsumption architecture and scheduler to schedule clusters of sequential and parallel events. The proposed system utilizes a highly efficient and scalable tetrahedral decomposition approach to realistically simulate rubble formation. Experimental results demonstrate that the proposed system has the capability to realistically simulate rubble generation, rubble flyout and their primary and secondary impacts on surrounding objects including buildings, constructions, vehicles and pedestrians in clusters of sequential and parallel damage events.

Development of space simulation / net-laboratory system

NASA Astrophysics Data System (ADS)

Usui, H.; Matsumoto, H.; Ogino, T.; Fujimoto, M.; Omura, Y.; Okada, M.; Ueda, H. O.; Murata, T.; Kamide, Y.; Shinagawa, H.; Watanabe, S.; Machida, S.; Hada, T.

A research project for the development of space simulation / net-laboratory system was approved by Japan Science and Technology Corporation (JST) in the category of Research and Development for Applying Advanced Computational Science and Technology(ACT-JST) in 2000. This research project, which continues for three years, is a collaboration with an astrophysical simulation group as well as other space simulation groups which use MHD and hybrid models. In this project, we develop a proto type of unique simulation system which enables us to perform simulation runs by providing or selecting plasma parameters through Web-based interface on the internet. We are also developing an on-line database system for space simulation from which we will be able to search and extract various information such as simulation method and program, manuals, and typical simulation results in graphic or ascii format. This unique system will help the simulation beginners to start simulation study without much difficulty or effort, and contribute to the promotion of simulation studies in the STP field. In this presentation, we will report the overview and the current status of the project.

Cosimulation of embedded system using RTOS software simulator

NASA Astrophysics Data System (ADS)

Wang, Shihao; Duan, Zhigang; Liu, Mingye

2003-09-01

Embedded system design often employs co-simulation to verify system's function; one efficient verification tool of software is Instruction Set Simulator (ISS). As a full functional model of target CPU, ISS interprets instruction of embedded software step by step, which usually is time-consuming since it simulates at low-level. Hence ISS often becomes the bottleneck of co-simulation in a complicated system. In this paper, a new software verification tools, the RTOS software simulator (RSS) was presented. The mechanism of its operation was described in a full details. In RSS method, RTOS API is extended and hardware simulator driver is adopted to deal with data-exchange and synchronism between the two simulators.

Simulation of a Geiger-Mode Imaging LADAR System for Performance Assessment

PubMed Central

Kim, Seongjoon; Lee, Impyeong; Kwon, Yong Joon

2013-01-01

As LADAR systems applications gradually become more diverse, new types of systems are being developed. When developing new systems, simulation studies are an essential prerequisite. A simulator enables performance predictions and optimal system parameters at the design level, as well as providing sample data for developing and validating application algorithms. The purpose of the study is to propose a method for simulating a Geiger-mode imaging LADAR system. We develop simulation software to assess system performance and generate sample data for the applications. The simulation is based on three aspects of modeling—the geometry, radiometry and detection. The geometric model computes the ranges to the reflection points of the laser pulses. The radiometric model generates the return signals, including the noises. The detection model determines the flight times of the laser pulses based on the nature of the Geiger-mode detector. We generated sample data using the simulator with the system parameters and analyzed the detection performance by comparing the simulated points to the reference points. The proportion of the outliers in the simulated points reached 25.53%, indicating the need for efficient outlier elimination algorithms. In addition, the false alarm rate and dropout rate of the designed system were computed as 1.76% and 1.06%, respectively. PMID:23823970

Understanding Emergency Care Delivery Through Computer Simulation Modeling.

PubMed

Laker, Lauren F; Torabi, Elham; France, Daniel J; Froehle, Craig M; Goldlust, Eric J; Hoot, Nathan R; Kasaie, Parastu; Lyons, Michael S; Barg-Walkow, Laura H; Ward, Michael J; Wears, Robert L

2018-02-01

In 2017, Academic Emergency Medicine convened a consensus conference entitled, "Catalyzing System Change through Health Care Simulation: Systems, Competency, and Outcomes." This article, a product of the breakout session on "understanding complex interactions through systems modeling," explores the role that computer simulation modeling can and should play in research and development of emergency care delivery systems. This article discusses areas central to the use of computer simulation modeling in emergency care research. The four central approaches to computer simulation modeling are described (Monte Carlo simulation, system dynamics modeling, discrete-event simulation, and agent-based simulation), along with problems amenable to their use and relevant examples to emergency care. Also discussed is an introduction to available software modeling platforms and how to explore their use for research, along with a research agenda for computer simulation modeling. Through this article, our goal is to enhance adoption of computer simulation, a set of methods that hold great promise in addressing emergency care organization and design challenges. © 2017 by the Society for Academic Emergency Medicine.

A View on Future Building System Modeling and Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wetter, Michael

This chapter presents what a future environment for building system modeling and simulation may look like. As buildings continue to require increased performance and better comfort, their energy and control systems are becoming more integrated and complex. We therefore focus in this chapter on the modeling, simulation and analysis of building energy and control systems. Such systems can be classified as heterogeneous systems because they involve multiple domains, such as thermodynamics, fluid dynamics, heat and mass transfer, electrical systems, control systems and communication systems. Also, they typically involve multiple temporal and spatial scales, and their evolution can be described bymore » coupled differential equations, discrete equations and events. Modeling and simulating such systems requires a higher level of abstraction and modularisation to manage the increased complexity compared to what is used in today's building simulation programs. Therefore, the trend towards more integrated building systems is likely to be a driving force for changing the status quo of today's building simulation programs. Thischapter discusses evolving modeling requirements and outlines a path toward a future environment for modeling and simulation of heterogeneous building systems.A range of topics that would require many additional pages of discussion has been omitted. Examples include computational fluid dynamics for air and particle flow in and around buildings, people movement, daylight simulation, uncertainty propagation and optimisation methods for building design and controls. For different discussions and perspectives on the future of building modeling and simulation, we refer to Sahlin (2000), Augenbroe (2001) and Malkawi and Augenbroe (2004).« less

The Shuttle Mission Simulator computer generated imagery

NASA Technical Reports Server (NTRS)

Henderson, T. H.

1984-01-01

Equipment available in the primary training facility for the Space Transportation System (STS) flight crews includes the Fixed Base Simulator, the Motion Base Simulator, the Spacelab Simulator, and the Guidance and Navigation Simulator. The Shuttle Mission Simulator (SMS) consists of the Fixed Base Simulator and the Motion Base Simulator. The SMS utilizes four visual Computer Generated Image (CGI) systems. The Motion Base Simulator has a forward crew station with six-degrees of freedom motion simulation. Operation of the Spacelab Simulator is planned for the spring of 1983. The Guidance and Navigation Simulator went into operation in 1982. Aspects of orbital visual simulation are discussed, taking into account the earth scene, payload simulation, the generation and display of 1079 stars, the simulation of sun glare, and Reaction Control System jet firing plumes. Attention is also given to landing site visual simulation, and night launch and landing simulation.

Plasma ET-1 Concentrations are Elevated in Patients with Hypertension - Meta-Analysis of Clinical Studies.

PubMed

Xu, Mei; Lu, Yong-Ping; Hasan, Ahmed Abdallah; Hocher, Berthold

2017-01-01

A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive patients where antihypertensive medication was discontinued for at least two weeks. Based on the principle of Cochrane systematic reviews, case control studies (CCSs) in PubMed (Medline) and Google Scholar designed to identify the role of endothelin-1 (ET-1) in the pathophysiological of hypertension were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects models. Eleven studies fulfilling our in- and exclusion criteria were eligible for this meta-analysis. These studies included 450 hypertensive patients and 328 controls. Our meta-analysis revealed that ET-1 plasma concentrations were higher in hypertensive patients as compared to the control patients [mean difference between groups 1.57 pg/mL, 95%CI [0.47∼2.68, P = 0.005]. These finding were driven by patients having systolic blood pressure higher than 160 mmHg and diastolic blood pressure higher than 100 mmHg. This meta-analysis showed that hypertensive patients do have elevated plasma ET-1 concentrations. This finding is driven by those patients with high systolic/diastolic blood pressure. Given that the ET-1 gene did not appear in any of the whole genome association studies searching for hypertension associated gene loci, it is very likely that the elevated plasma ET-1 concentrations in hypertensive patients are secondary to hypertension and may reflect endothelial cell damage. © 2017 The Author(s). Published by S. Karger AG, Basel.

Issues in visual support to real-time space system simulation solved in the Systems Engineering Simulator

NASA Technical Reports Server (NTRS)

Yuen, Vincent K.

1989-01-01

The Systems Engineering Simulator has addressed the major issues in providing visual data to its real-time man-in-the-loop simulations. Out-the-window views and CCTV views are provided by three scene systems to give the astronauts their real-world views. To expand the window coverage for the Space Station Freedom workstation a rotating optics system is used to provide the widest field of view possible. To provide video signals to as many viewpoints as possible, windows and CCTVs, with a limited amount of hardware, a video distribution system has been developed to time-share the video channels among viewpoints at the selection of the simulation users. These solutions have provided the visual simulation facility for real-time man-in-the-loop simulations for the NASA space program.

A Cryogenic Fluid System Simulation in Support of Integrated Systems Health Management

NASA Technical Reports Server (NTRS)

Barber, John P.; Johnston, Kyle B.; Daigle, Matthew

2013-01-01

Simulations serve as important tools throughout the design and operation of engineering systems. In the context of sys-tems health management, simulations serve many uses. For one, the underlying physical models can be used by model-based health management tools to develop diagnostic and prognostic models. These simulations should incorporate both nominal and faulty behavior with the ability to inject various faults into the system. Such simulations can there-fore be used for operator training, for both nominal and faulty situations, as well as for developing and prototyping health management algorithms. In this paper, we describe a methodology for building such simulations. We discuss the design decisions and tools used to build a simulation of a cryogenic fluid test bed, and how it serves as a core technology for systems health management development and maturation.

Simulating New Drop Test Vehicles and Test Techniques for the Orion CEV Parachute Assembly System

NASA Technical Reports Server (NTRS)

Morris, Aaron L.; Fraire, Usbaldo, Jr.; Bledsoe, Kristin J.; Ray, Eric; Moore, Jim W.; Olson, Leah M.

2011-01-01

The Crew Exploration Vehicle Parachute Assembly System (CPAS) project is engaged in a multi-year design and test campaign to qualify a parachute recovery system for human use on the Orion Spacecraft. Test and simulation techniques have evolved concurrently to keep up with the demands of a challenging and complex system. The primary simulations used for preflight predictions and post-test data reconstructions are Decelerator System Simulation (DSS), Decelerator System Simulation Application (DSSA), and Drop Test Vehicle Simulation (DTV-SIM). The goal of this paper is to provide a roadmap to future programs on the test technique challenges and obstacles involved in executing a large-scale, multi-year parachute test program. A focus on flight simulation modeling and correlation to test techniques executed to obtain parachute performance parameters are presented.

Analysis of the use of industrial control systems in simulators: state of the art and basic guidelines.

PubMed

Carrasco, Juan A; Dormido, Sebastián

2006-04-01

The use of industrial control systems in simulators facilitates the execution of engineering activities related with the installation and the optimization of the control systems in real plants. "Industrial control system" intends to be a valid term that would represent all the control systems which can be installed in an industrial plant, ranging from complex distributed control systems and SCADA packages to small single control devices. This paper summarizes the current alternatives for the development of simulators of industrial plants and presents an analysis of the process of integrating an industrial control system into a simulator, with the aim of helping in the installation of real control systems in simulators.

Dynamic Data-Driven UAV Network for Plume Characterization

DTIC Science & Technology

2016-05-23

data collection where simulations and measurements become a symbiotic feedback control system where simulations inform measurement locations and the...and measurements become a symbiotic feedback control system where simulations inform measurement locations and the measured data augments simulations...data analysis techniques with mobile sensor data collection where simulations and measurements become a symbiotic feedback control system where

System Simulation Modeling: A Case Study Illustration of the Model Development Life Cycle

Treesearch

Janice K. Wiedenbeck; D. Earl Kline

1994-01-01

Systems simulation modeling techniques offer a method of representing the individual elements of a manufacturing system and their interactions. By developing and experimenting with simulation models, one can obtain a better understanding of the overall physical system. Forest products industries are beginning to understand the importance of simulation modeling to help...

Design and implementation of laser target simulator in hardware-in-the-loop simulation system based on LabWindows/CVI and RTX

NASA Astrophysics Data System (ADS)

Tong, Qiujie; Wang, Qianqian; Li, Xiaoyang; Shan, Bin; Cui, Xuntai; Li, Chenyu; Peng, Zhong

2016-11-01

In order to satisfy the requirements of the real-time and generality, a laser target simulator in semi-physical simulation system based on RTX+LabWindows/CVI platform is proposed in this paper. Compared with the upper-lower computers simulation platform architecture used in the most of the real-time system now, this system has better maintainability and portability. This system runs on the Windows platform, using Windows RTX real-time extension subsystem to ensure the real-time performance of the system combining with the reflective memory network to complete some real-time tasks such as calculating the simulation model, transmitting the simulation data, and keeping real-time communication. The real-time tasks of simulation system run under the RTSS process. At the same time, we use the LabWindows/CVI to compile a graphical interface, and complete some non-real-time tasks in the process of simulation such as man-machine interaction, display and storage of the simulation data, which run under the Win32 process. Through the design of RTX shared memory and task scheduling algorithm, the data interaction between the real-time tasks process of RTSS and non-real-time tasks process of Win32 is completed. The experimental results show that this system has the strongly real-time performance, highly stability, and highly simulation accuracy. At the same time, it also has the good performance of human-computer interaction.

Reconstructing the ideal results of a perturbed analog quantum simulator

NASA Astrophysics Data System (ADS)

Schwenk, Iris; Reiner, Jan-Michael; Zanker, Sebastian; Tian, Lin; Leppäkangas, Juha; Marthaler, Michael

2018-04-01

Well-controlled quantum systems can potentially be used as quantum simulators. However, a quantum simulator is inevitably perturbed by coupling to additional degrees of freedom. This constitutes a major roadblock to useful quantum simulations. So far there are only limited means to understand the effect of perturbation on the results of quantum simulation. Here we present a method which, in certain circumstances, allows for the reconstruction of the ideal result from measurements on a perturbed quantum simulator. We consider extracting the value of the correlator 〈Ôi(t ) Ôj(0 ) 〉 from the simulated system, where Ôi are the operators which couple the system to its environment. The ideal correlator can be straightforwardly reconstructed by using statistical knowledge of the environment, if any n -time correlator of operators Ôi of the ideal system can be written as products of two-time correlators. We give an approach to verify the validity of this assumption experimentally by additional measurements on the perturbed quantum simulator. The proposed method can allow for reliable quantum simulations with systems subjected to environmental noise without adding an overhead to the quantum system.

A simulation framework for the CMS Track Trigger electronics

NASA Astrophysics Data System (ADS)

Amstutz, C.; Magazzù, G.; Weber, M.; Palla, F.

2015-03-01

A simulation framework has been developed to test and characterize algorithms, architectures and hardware implementations of the vastly complex CMS Track Trigger for the high luminosity upgrade of the CMS experiment at the Large Hadron Collider in Geneva. High-level SystemC models of all system components have been developed to simulate a portion of the track trigger. The simulation of the system components together with input data from physics simulations allows evaluating figures of merit, like delays or bandwidths, under realistic conditions. The use of SystemC for high-level modelling allows co-simulation with models developed in Hardware Description Languages, e.g. VHDL or Verilog. Therefore, the simulation framework can also be used as a test bench for digital modules developed for the final system.

Simulation and evaluation of the Sh-2F helicopter in a shipboard environment using the interchangeable cab system

NASA Technical Reports Server (NTRS)

Paulk, C. H., Jr.; Astill, D. L.; Donley, S. T.

1983-01-01

The operation of the SH-2F helicopter from the decks of small ships in adverse weather was simulated using a large amplitude vertical motion simulator, a wide angle computer generated imagery visual system, and an interchangeable cab (ICAB). The simulation facility, the mathematical programs, and the validation method used to ensure simulation fidelity are described. The results show the simulator to be a useful tool in simulating the ship-landing problem. Characteristics of the ICAB system and ways in which the simulation can be improved are presented.

Using numeric simulation in an online e-learning environment to teach functional physiological contexts.

PubMed

Christ, Andreas; Thews, Oliver

2016-04-01

Mathematical models are suitable to simulate complex biological processes by a set of non-linear differential equations. These simulation models can be used as an e-learning tool in medical education. However, in many cases these mathematical systems have to be treated numerically which is computationally intensive. The aim of the study was to develop a system for numerical simulation to be used in an online e-learning environment. In the software system the simulation is located on the server as a CGI application. The user (student) selects the boundary conditions for the simulation (e.g., properties of a simulated patient) on the browser. With these parameters the simulation on the server is started and the simulation result is re-transferred to the browser. With this system two examples of e-learning units were realized. The first one uses a multi-compartment model of the glucose-insulin control loop for the simulation of the plasma glucose level after a simulated meal or during diabetes (including treatment by subcutaneous insulin application). The second one simulates the ion transport leading to the resting and action potential in nerves. The student can vary parameters systematically to explore the biological behavior of the system. The described system is able to simulate complex biological processes and offers the possibility to use these models in an online e-learning environment. As far as the underlying principles can be described mathematically, this type of system can be applied to a broad spectrum of biomedical or natural scientific topics. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Using CONFIG for Simulation of Operation of Water Recovery Subsystems for Advanced Control Software Evaluation

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Flores, Luis; Fleming, Land; Throop, Daiv

2002-01-01

A hybrid discrete/continuous simulation tool, CONFIG, has been developed to support evaluation of the operability life support systems. CON FIG simulates operations scenarios in which flows and pressures change continuously while system reconfigurations occur as discrete events. In simulations, intelligent control software can interact dynamically with hardware system models. CONFIG simulations have been used to evaluate control software and intelligent agents for automating life support systems operations. A CON FIG model of an advanced biological water recovery system has been developed to interact with intelligent control software that is being used in a water system test at NASA Johnson Space Center

Block Oriented Simulation System (BOSS)

NASA Technical Reports Server (NTRS)

Ratcliffe, Jaimie

1988-01-01

Computer simulation is assuming greater importance as a flexible and expedient approach to modeling system and subsystem behavior. Simulation has played a key role in the growth of complex, multiple access space communications such as those used by the space shuttle and the TRW-built Tracking and Data Relay Satellites (TDRS). A powerful new simulator for use in designing and modeling the communication system of NASA's planned Space Station is being developed. Progress to date on the Block (Diagram) Oriented Simulation System (BOSS) is described.

Development of automation and robotics for space via computer graphic simulation methods

NASA Technical Reports Server (NTRS)

Fernandez, Ken

1988-01-01

A robot simulation system, has been developed to perform automation and robotics system design studies. The system uses a procedure-oriented solid modeling language to produce a model of the robotic mechanism. The simulator generates the kinematics, inverse kinematics, dynamics, control, and real-time graphic simulations needed to evaluate the performance of the model. Simulation examples are presented, including simulation of the Space Station and the design of telerobotics for the Orbital Maneuvering Vehicle.

G189A analytical simulation of the RITE Integrated Waste Management-Water System

NASA Technical Reports Server (NTRS)

Coggi, J. V.; Clonts, S. E.

1974-01-01

This paper discusses the computer simulation of the Integrated Waste Management-Water System Using Radioisotopes for Thermal Energy (RITE) and applications of the simulation. Variations in the system temperature and flows due to particular operating conditions and variations in equipment heating loads imposed on the system were investigated with the computer program. The results were assessed from the standpoint of the computed dynamic characteristics of the system and the potential applications of the simulation to system development and vehicle integration.

Ground Simulator Studies of the Effects of Valve Friction, Stick Friction, Flexibility, and Backwash on Power Control System Quality

NASA Technical Reports Server (NTRS)

Brown, B Porter

1958-01-01

Report presents results of tests made on a power control system by means of a ground simulator to determine the effects of various combinations of valve friction and stick friction on the ability of the pilot to control the system. Various friction conditions were simulated with a rigid control system, a flexible system, and a rigid system having some backlash. For the tests, the period and damping of the simulated airplane were held constant.

Advanced simulation model for IPM motor drive with considering phase voltage and stator inductance

NASA Astrophysics Data System (ADS)

Lee, Dong-Myung; Park, Hyun-Jong; Lee, Ju

2016-10-01

This paper proposes an advanced simulation model of driving system for Interior Permanent Magnet (IPM) BrushLess Direct Current (BLDC) motors driven by 120-degree conduction method (two-phase conduction method, TPCM) that is widely used for sensorless control of BLDC motors. BLDC motors can be classified as SPM (Surface mounted Permanent Magnet) and IPM motors. Simulation model of driving system with SPM motors is simple due to the constant stator inductance regardless of the rotor position. Simulation models of SPM motor driving system have been proposed in many researches. On the other hand, simulation models for IPM driving system by graphic-based simulation tool such as Matlab/Simulink have not been proposed. Simulation study about driving system of IPMs with TPCM is complex because stator inductances of IPM vary with the rotor position, as permanent magnets are embedded in the rotor. To develop sensorless scheme or improve control performance, development of control algorithm through simulation study is essential, and the simulation model that accurately reflects the characteristic of IPM is required. Therefore, this paper presents the advanced simulation model of IPM driving system, which takes into account the unique characteristic of IPM due to the position-dependent inductances. The validity of the proposed simulation model is validated by comparison to experimental and simulation results using IPM with TPCM control scheme.

Computer-generated forces in distributed interactive simulation

NASA Astrophysics Data System (ADS)

Petty, Mikel D.

1995-04-01

Distributed Interactive Simulation (DIS) is an architecture for building large-scale simulation models from a set of independent simulator nodes communicating via a common network protocol. DIS is most often used to create a simulated battlefield for military training. Computer Generated Forces (CGF) systems control large numbers of autonomous battlefield entities in a DIS simulation using computer equipment and software rather than humans in simulators. CGF entities serve as both enemy forces and supplemental friendly forces in a DIS exercise. Research into various aspects of CGF systems is ongoing. Several CGF systems have been implemented.

Use case driven approach to develop simulation model for PCS of APR1400 simulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong Wook, Kim; Hong Soo, Kim; Hyeon Tae, Kang

2006-07-01

The full-scope simulator is being developed to evaluate specific design feature and to support the iterative design and validation in the Man-Machine Interface System (MMIS) design of Advanced Power Reactor (APR) 1400. The simulator consists of process model, control logic model, and MMI for the APR1400 as well as the Power Control System (PCS). In this paper, a use case driven approach is proposed to develop a simulation model for PCS. In this approach, a system is considered from the point of view of its users. User's view of the system is based on interactions with the system and themore » resultant responses. In use case driven approach, we initially consider the system as a black box and look at its interactions with the users. From these interactions, use cases of the system are identified. Then the system is modeled using these use cases as functions. Lower levels expand the functionalities of each of these use cases. Hence, starting from the topmost level view of the system, we proceeded down to the lowest level (the internal view of the system). The model of the system thus developed is use case driven. This paper will introduce the functionality of the PCS simulation model, including a requirement analysis based on use case and the validation result of development of PCS model. The PCS simulation model using use case will be first used during the full-scope simulator development for nuclear power plant and will be supplied to Shin-Kori 3 and 4 plant. The use case based simulation model development can be useful for the design and implementation of simulation models. (authors)« less

Research on an expert system for database operation of simulation-emulation math models. Volume 2, Phase 1: Results

NASA Technical Reports Server (NTRS)

Kawamura, K.; Beale, G. O.; Schaffer, J. D.; Hsieh, B. J.; Padalkar, S.; Rodriguez-Moscoso, J. J.

1985-01-01

A reference manual is provided for NESS, a simulation expert system. This manual gives user information regarding starting and operating NASA expert simulation system (NESS). This expert system provides an intelligent interface to a generic simulation program for spacecraft attitude control problems. A menu of the functions the system can perform is provided. Control repeated returns to this menu after executing each user request.

Predicting System Accidents with Model Analysis During Hybrid Simulation

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Fleming, Land D.; Throop, David R.

2002-01-01

Standard discrete event simulation is commonly used to identify system bottlenecks and starving and blocking conditions in resources and services. The CONFIG hybrid discrete/continuous simulation tool can simulate such conditions in combination with inputs external to the simulation. This provides a means for evaluating the vulnerability to system accidents of a system's design, operating procedures, and control software. System accidents are brought about by complex unexpected interactions among multiple system failures , faulty or misleading sensor data, and inappropriate responses of human operators or software. The flows of resource and product materials play a central role in the hazardous situations that may arise in fluid transport and processing systems. We describe the capabilities of CONFIG for simulation-time linear circuit analysis of fluid flows in the context of model-based hazard analysis. We focus on how CONFIG simulates the static stresses in systems of flow. Unlike other flow-related properties, static stresses (or static potentials) cannot be represented by a set of state equations. The distribution of static stresses is dependent on the specific history of operations performed on a system. We discuss the use of this type of information in hazard analysis of system designs.

Open-source framework for power system transmission and distribution dynamics co-simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Renke; Fan, Rui; Daily, Jeff

The promise of the smart grid entails more interactions between the transmission and distribution networks, and there is an immediate need for tools to provide the comprehensive modelling and simulation required to integrate operations at both transmission and distribution levels. Existing electromagnetic transient simulators can perform simulations with integration of transmission and distribution systems, but the computational burden is high for large-scale system analysis. For transient stability analysis, currently there are only separate tools for simulating transient dynamics of the transmission and distribution systems. In this paper, we introduce an open source co-simulation framework “Framework for Network Co-Simulation” (FNCS), togethermore » with the decoupled simulation approach that links existing transmission and distribution dynamic simulators through FNCS. FNCS is a middleware interface and framework that manages the interaction and synchronization of the transmission and distribution simulators. Preliminary testing results show the validity and capability of the proposed open-source co-simulation framework and the decoupled co-simulation methodology.« less

Interactive Learning Environment: Web-based Virtual Hydrological Simulation System using Augmented and Immersive Reality

NASA Astrophysics Data System (ADS)

Demir, I.

2014-12-01

Recent developments in internet technologies make it possible to manage and visualize large data on the web. Novel visualization techniques and interactive user interfaces allow users to create realistic environments, and interact with data to gain insight from simulations and environmental observations. The hydrological simulation system is a web-based 3D interactive learning environment for teaching hydrological processes and concepts. The simulation systems provides a visually striking platform with realistic terrain information, and water simulation. Students can create or load predefined scenarios, control environmental parameters, and evaluate environmental mitigation alternatives. The web-based simulation system provides an environment for students to learn about the hydrological processes (e.g. flooding and flood damage), and effects of development and human activity in the floodplain. The system utilizes latest web technologies and graphics processing unit (GPU) for water simulation and object collisions on the terrain. Users can access the system in three visualization modes including virtual reality, augmented reality, and immersive reality using heads-up display. The system provides various scenarios customized to fit the age and education level of various users. This presentation provides an overview of the web-based flood simulation system, and demonstrates the capabilities of the system for various visualization and interaction modes.

75 FR 65614 - Availability for Non-Exclusive or Partially-Exclusive Licensing of Invention Concerning...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-26

... Licensing of Invention Concerning Obstetrics Simulation and Training Method System AGENCY: Department of the... invention set forth in U.S. Patent Application Serial No. 12/670,250, entitled ``Obstetrics Simulation and... simulation system. An embodiment of the invention provides an obstetrics simulation system compromising an...

14 CFR Appendix E to Part 60 - Qualification Performance Standards for Quality Management Systems for Flight Simulation Training...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Quality Management Systems for Flight Simulation Training Devices E Appendix E to Part 60 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION...—Qualification Performance Standards for Quality Management Systems for Flight Simulation Training Devices Begin...

DDS: The Dental Diagnostic Simulation System.

ERIC Educational Resources Information Center

Tira, Daniel E.

The Dental Diagnostic Simulation (DDS) System provides an alternative to simulation systems which represent diagnostic case studies of relatively limited scope. It may be used to generate simulated case studies in all of the dental specialty areas with case materials progressing through the gamut of the diagnostic process. The generation of a…

Simulation of a synergistic six-post motion system on the flight simulator for advanced aircraft at NASA-Ames

NASA Technical Reports Server (NTRS)

Bose, S. C.; Parris, B. L.

1977-01-01

Motion system drive philosophy and corresponding real-time software have been developed for the purpose of simulating the characteristics of a typical synergistic Six-Post Motion System (SPMS) on the Flight Simulator for Advanced Aircraft (FSAA) at NASA-Ames which is a non-synergistic motion system. This paper gives a brief description of these two types of motion systems and the general methods of producing motion cues of the FSAA. An actuator extension transformation which allows the simulation of a typical SPMS by appropriate drive washout and variable position limiting is described.

A system for automatic evaluation of simulation software

NASA Technical Reports Server (NTRS)

Ryan, J. P.; Hodges, B. C.

1976-01-01

Within the field of computer software, simulation and verification are complementary processes. Simulation methods can be used to verify software by performing variable range analysis. More general verification procedures, such as those described in this paper, can be implicitly, viewed as attempts at modeling the end-product software. From software requirement methodology, each component of the verification system has some element of simulation to it. Conversely, general verification procedures can be used to analyze simulation software. A dynamic analyzer is described which can be used to obtain properly scaled variables for an analog simulation, which is first digitally simulated. In a similar way, it is thought that the other system components and indeed the whole system itself have the potential of being effectively used in a simulation environment.

Development of a Prototype Simulation Executive with Zooming in the Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Afjeh, Abdollah A.

1995-01-01

A major difficulty in designing aeropropulsion systems is that of identifying and understanding the interactions between the separate engine components and disciplines (e.g., fluid mechanics, structural mechanics, heat transfer, material properties, etc.). The traditional analysis approach is to decompose the system into separate components with the interaction between components being evaluated by the application of each of the single disciplines in a sequential manner. Here, one discipline uses information from the calculation of another discipline to determine the effects of component coupling. This approach, however, may not properly identify the consequences of these effects during the design phase, leaving the interactions to be discovered and evaluated during engine testing. This contributes to the time and cost of developing new propulsion systems as, typically, several design-build-test cycles are needed to fully identify multidisciplinary effects and reach the desired system performance. The alternative to sequential isolated component analysis is to use multidisciplinary coupling at a more fundamental level. This approach has been made more plausible due to recent advancements in computation simulation along with application of concurrent engineering concepts. Computer simulation systems designed to provide an environment which is capable of integrating the various disciplines into a single simulation system have been proposed and are currently being developed. One such system is being developed by the Numerical Propulsion System Simulation (NPSS) project. The NPSS project, being developed at the Interdisciplinary Technology Office at the NASA Lewis Research Center is a 'numerical test cell' designed to provide for comprehensive computational design and analysis of aerospace propulsion systems. It will provide multi-disciplinary analyses on a variety of computational platforms, and a user-interface consisting of expert systems, data base management and visualization tools, to allow the designer to investigate the complex interactions inherent in these systems. An interactive programming software system, known as the Application Visualization System (AVS), was utilized for the development of the propulsion system simulation. The modularity of this system provides the ability to couple propulsion system components, as well as disciplines, and provides for the ability to integrate existing, well established analysis codes into the overall system simulation. This feature allows the user to customize the simulation model by inserting desired analysis codes. The prototypical simulation environment for multidisciplinary analysis, called Turbofan Engine System Simulation (TESS), which incorporates many of the characteristics of the simulation environment proposed herein, is detailed.

Distributed Engine Control Empirical/Analytical Verification Tools

NASA Technical Reports Server (NTRS)

DeCastro, Jonathan; Hettler, Eric; Yedavalli, Rama; Mitra, Sayan

2013-01-01

NASA's vision for an intelligent engine will be realized with the development of a truly distributed control system featuring highly reliable, modular, and dependable components capable of both surviving the harsh engine operating environment and decentralized functionality. A set of control system verification tools was developed and applied to a C-MAPSS40K engine model, and metrics were established to assess the stability and performance of these control systems on the same platform. A software tool was developed that allows designers to assemble easily a distributed control system in software and immediately assess the overall impacts of the system on the target (simulated) platform, allowing control system designers to converge rapidly on acceptable architectures with consideration to all required hardware elements. The software developed in this program will be installed on a distributed hardware-in-the-loop (DHIL) simulation tool to assist NASA and the Distributed Engine Control Working Group (DECWG) in integrating DCS (distributed engine control systems) components onto existing and next-generation engines.The distributed engine control simulator blockset for MATLAB/Simulink and hardware simulator provides the capability to simulate virtual subcomponents, as well as swap actual subcomponents for hardware-in-the-loop (HIL) analysis. Subcomponents can be the communication network, smart sensor or actuator nodes, or a centralized control system. The distributed engine control blockset for MATLAB/Simulink is a software development tool. The software includes an engine simulation, a communication network simulation, control algorithms, and analysis algorithms set up in a modular environment for rapid simulation of different network architectures; the hardware consists of an embedded device running parts of the CMAPSS engine simulator and controlled through Simulink. The distributed engine control simulation, evaluation, and analysis technology provides unique capabilities to study the effects of a given change to the control system in the context of the distributed paradigm. The simulation tool can support treatment of all components within the control system, both virtual and real; these include communication data network, smart sensor and actuator nodes, centralized control system (FADEC full authority digital engine control), and the aircraft engine itself. The DECsim tool can allow simulation-based prototyping of control laws, control architectures, and decentralization strategies before hardware is integrated into the system. With the configuration specified, the simulator allows a variety of key factors to be systematically assessed. Such factors include control system performance, reliability, weight, and bandwidth utilization.

Instrumented Architectural Simulation System

NASA Technical Reports Server (NTRS)

Delagi, B. A.; Saraiya, N.; Nishimura, S.; Byrd, G.

1987-01-01

Simulation of systems at an architectural level can offer an effective way to study critical design choices if (1) the performance of the simulator is adequate to examine designs executing significant code bodies, not just toy problems or small application fragements, (2) the details of the simulation include the critical details of the design, (3) the view of the design presented by the simulator instrumentation leads to useful insights on the problems with the design, and (4) there is enough flexibility in the simulation system so that the asking of unplanned questions is not suppressed by the weight of the mechanics involved in making changes either in the design or its measurement. A simulation system with these goals is described together with the approach to its implementation. Its application to the study of a particular class of multiprocessor hardware system architectures is illustrated.

DKIST Adaptive Optics System: Simulation Results

NASA Astrophysics Data System (ADS)

Marino, Jose; Schmidt, Dirk

2016-05-01

The 4 m class Daniel K. Inouye Solar Telescope (DKIST), currently under construction, will be equipped with an ultra high order solar adaptive optics (AO) system. The requirements and capabilities of such a solar AO system are beyond those of any other solar AO system currently in operation. We must rely on solar AO simulations to estimate and quantify its performance.We present performance estimation results of the DKIST AO system obtained with a new solar AO simulation tool. This simulation tool is a flexible and fast end-to-end solar AO simulator which produces accurate solar AO simulations while taking advantage of current multi-core computer technology. It relies on full imaging simulations of the extended field Shack-Hartmann wavefront sensor (WFS), which directly includes important secondary effects such as field dependent distortions and varying contrast of the WFS sub-aperture images.

Simulating storage part of application with Simgrid

NASA Astrophysics Data System (ADS)

Wang, Cong

2017-10-01

Design of a file system simulation and visualization system, using simgrid API and visualization techniques to help users understanding and improving the file system portion of their application. The core of the simulator is the API provided by simgrid, cluefs tracks and catches the procedure of the I/O operation. Run the simulator simulating this application to generate the output visualization file, which can visualize the I/O action proportion and time series. Users can also change the parameters in the configuration file to change the parameters of the storage system such as reading and writing bandwidth, users can also adjust the storage strategy, test the performance, getting reference to be much easier to optimize the storage system. We have tested all the aspects of the simulator, the results suggest that the simulator performance can be believable.

Integrating Soft Set Theory and Fuzzy Linguistic Model to Evaluate the Performance of Training Simulation Systems

PubMed Central

Chang, Kuei-Hu; Chang, Yung-Chia; Chain, Kai; Chung, Hsiang-Yu

2016-01-01

The advancement of high technologies and the arrival of the information age have caused changes to the modern warfare. The military forces of many countries have replaced partially real training drills with training simulation systems to achieve combat readiness. However, considerable types of training simulation systems are used in military settings. In addition, differences in system set up time, functions, the environment, and the competency of system operators, as well as incomplete information have made it difficult to evaluate the performance of training simulation systems. To address the aforementioned problems, this study integrated analytic hierarchy process, soft set theory, and the fuzzy linguistic representation model to evaluate the performance of various training simulation systems. Furthermore, importance–performance analysis was adopted to examine the influence of saving costs and training safety of training simulation systems. The findings of this study are expected to facilitate applying military training simulation systems, avoiding wasting of resources (e.g., low utility and idle time), and providing data for subsequent applications and analysis. To verify the method proposed in this study, the numerical examples of the performance evaluation of training simulation systems were adopted and compared with the numerical results of an AHP and a novel AHP-based ranking technique. The results verified that not only could expert-provided questionnaire information be fully considered to lower the repetition rate of performance ranking, but a two-dimensional graph could also be used to help administrators allocate limited resources, thereby enhancing the investment benefits and training effectiveness of a training simulation system. PMID:27598390

Extensible Adaptable Simulation Systems: Supporting Multiple Fidelity Simulations in a Common Environment

NASA Technical Reports Server (NTRS)

McLaughlin, Brian J.; Barrett, Larry K.

2012-01-01

Common practice in the development of simulation systems is meeting all user requirements within a single instantiation. The Joint Polar Satellite System (JPSS) presents a unique challenge to establish a simulation environment that meets the needs of a diverse user community while also spanning a multi-mission environment over decades of operation. In response, the JPSS Flight Vehicle Test Suite (FVTS) is architected with an extensible infrastructure that supports the operation of multiple observatory simulations for a single mission and multiple mission within a common system perimeter. For the JPSS-1 satellite, multiple fidelity flight observatory simulations are necessary to support the distinct user communities consisting of the Common Ground System development team, the Common Ground System Integration & Test team, and the Mission Rehearsal Team/Mission Operations Team. These key requirements present several challenges to FVTS development. First, the FVTS must ensure all critical user requirements are satisfied by at least one fidelity instance of the observatory simulation. Second, the FVTS must allow for tailoring of the system instances to function in diverse operational environments from the High-security operations environment at NOAA Satellite Operations Facility (NSOF) to the ground system factory floor. Finally, the FVTS must provide the ability to execute sustaining engineering activities on a subset of the system without impacting system availability to parallel users. The FVTS approach of allowing for multiple fidelity copies of observatory simulations represents a unique concept in simulator capability development and corresponds to the JPSS Ground System goals of establishing a capability that is flexible, extensible, and adaptable.

Integrating Soft Set Theory and Fuzzy Linguistic Model to Evaluate the Performance of Training Simulation Systems.

PubMed

Chang, Kuei-Hu; Chang, Yung-Chia; Chain, Kai; Chung, Hsiang-Yu

2016-01-01

The advancement of high technologies and the arrival of the information age have caused changes to the modern warfare. The military forces of many countries have replaced partially real training drills with training simulation systems to achieve combat readiness. However, considerable types of training simulation systems are used in military settings. In addition, differences in system set up time, functions, the environment, and the competency of system operators, as well as incomplete information have made it difficult to evaluate the performance of training simulation systems. To address the aforementioned problems, this study integrated analytic hierarchy process, soft set theory, and the fuzzy linguistic representation model to evaluate the performance of various training simulation systems. Furthermore, importance-performance analysis was adopted to examine the influence of saving costs and training safety of training simulation systems. The findings of this study are expected to facilitate applying military training simulation systems, avoiding wasting of resources (e.g., low utility and idle time), and providing data for subsequent applications and analysis. To verify the method proposed in this study, the numerical examples of the performance evaluation of training simulation systems were adopted and compared with the numerical results of an AHP and a novel AHP-based ranking technique. The results verified that not only could expert-provided questionnaire information be fully considered to lower the repetition rate of performance ranking, but a two-dimensional graph could also be used to help administrators allocate limited resources, thereby enhancing the investment benefits and training effectiveness of a training simulation system.

Knowledge-based simulation for aerospace systems

NASA Technical Reports Server (NTRS)

Will, Ralph W.; Sliwa, Nancy E.; Harrison, F. Wallace, Jr.

1988-01-01

Knowledge-based techniques, which offer many features that are desirable in the simulation and development of aerospace vehicle operations, exhibit many similarities to traditional simulation packages. The eventual solution of these systems' current symbolic processing/numeric processing interface problem will lead to continuous and discrete-event simulation capabilities in a single language, such as TS-PROLOG. Qualitative, totally-symbolic simulation methods are noted to possess several intrinsic characteristics that are especially revelatory of the system being simulated, and capable of insuring that all possible behaviors are considered.

System analysis for the Huntsville Operational Support Center distributed computer system

NASA Technical Reports Server (NTRS)

Ingels, F. M.; Mauldin, J.

1984-01-01

The Huntsville Operations Support Center (HOSC) is a distributed computer system used to provide real time data acquisition, analysis and display during NASA space missions and to perform simulation and study activities during non-mission times. The primary purpose is to provide a HOSC system simulation model that is used to investigate the effects of various HOSC system configurations. Such a model would be valuable in planning the future growth of HOSC and in ascertaining the effects of data rate variations, update table broadcasting and smart display terminal data requirements on the HOSC HYPERchannel network system. A simulation model was developed in PASCAL and results of the simulation model for various system configuraions were obtained. A tutorial of the model is presented and the results of simulation runs are presented. Some very high data rate situations were simulated to observe the effects of the HYPERchannel switch over from contention to priority mode under high channel loading.

Analyzing Robotic Kinematics Via Computed Simulations

NASA Technical Reports Server (NTRS)

Carnahan, Timothy M.

1992-01-01

Computing system assists in evaluation of kinematics of conceptual robot. Displays positions and motions of robotic manipulator within work cell. Also displays interactions between robotic manipulator and other objects. Results of simulation displayed on graphical computer workstation. System includes both off-the-shelf software originally developed for automotive industry and specially developed software. Simulation system also used to design human-equivalent hand, to model optical train in infrared system, and to develop graphical interface for teleoperator simulation system.

Virtual Observation System for Earth System Model: An Application to ACME Land Model Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Dali; Yuan, Fengming; Hernandez, Benjamin

Investigating and evaluating physical-chemical-biological processes within an Earth system model (EMS) can be very challenging due to the complexity of both model design and software implementation. A virtual observation system (VOS) is presented to enable interactive observation of these processes during system simulation. Based on advance computing technologies, such as compiler-based software analysis, automatic code instrumentation, and high-performance data transport, the VOS provides run-time observation capability, in-situ data analytics for Earth system model simulation, model behavior adjustment opportunities through simulation steering. A VOS for a terrestrial land model simulation within the Accelerated Climate Modeling for Energy model is also presentedmore » to demonstrate the implementation details and system innovations.« less

Virtual Observation System for Earth System Model: An Application to ACME Land Model Simulations

DOE PAGES

Wang, Dali; Yuan, Fengming; Hernandez, Benjamin; ...

2017-01-01

Investigating and evaluating physical-chemical-biological processes within an Earth system model (EMS) can be very challenging due to the complexity of both model design and software implementation. A virtual observation system (VOS) is presented to enable interactive observation of these processes during system simulation. Based on advance computing technologies, such as compiler-based software analysis, automatic code instrumentation, and high-performance data transport, the VOS provides run-time observation capability, in-situ data analytics for Earth system model simulation, model behavior adjustment opportunities through simulation steering. A VOS for a terrestrial land model simulation within the Accelerated Climate Modeling for Energy model is also presentedmore » to demonstrate the implementation details and system innovations.« less

Operating system for a real-time multiprocessor propulsion system simulator

NASA Technical Reports Server (NTRS)

Cole, G. L.

1984-01-01

The success of the Real Time Multiprocessor Operating System (RTMPOS) in the development and evaluation of experimental hardware and software systems for real time interactive simulation of air breathing propulsion systems was evaluated. The Real Time Multiprocessor Operating System (RTMPOS) provides the user with a versatile, interactive means for loading, running, debugging and obtaining results from a multiprocessor based simulator. A front end processor (FEP) serves as the simulator controller and interface between the user and the simulator. These functions are facilitated by the RTMPOS which resides on the FEP. The RTMPOS acts in conjunction with the FEP's manufacturer supplied disk operating system that provides typical utilities like an assembler, linkage editor, text editor, file handling services, etc. Once a simulation is formulated, the RTMPOS provides for engineering level, run time operations such as loading, modifying and specifying computation flow of programs, simulator mode control, data handling and run time monitoring. Run time monitoring is a powerful feature of RTMPOS that allows the user to record all actions taken during a simulation session and to receive advisories from the simulator via the FEP. The RTMPOS is programmed mainly in PASCAL along with some assembly language routines. The RTMPOS software is easily modified to be applicable to hardware from different manufacturers.

Application of control theory to dynamic systems simulation

NASA Technical Reports Server (NTRS)

Auslander, D. M.; Spear, R. C.; Young, G. E.

1982-01-01

The application of control theory is applied to dynamic systems simulation. Theory and methodology applicable to controlled ecological life support systems are considered. Spatial effects on system stability, design of control systems with uncertain parameters, and an interactive computing language (PARASOL-II) designed for dynamic system simulation, report quality graphics, data acquisition, and simple real time control are discussed.

21 CFR 1020.32 - Fluoroscopic equipment.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Radiation therapy simulation systems shall be exempt from this requirement provided the systems are intended... 10, 2006, other than radiation therapy simulation systems, the following applies: (A) Neither the... fluoroscopic equipment manufactured on or after June 10, 2006, other than radiation therapy simulation systems...

Simulator for concurrent processing data flow architectures

NASA Technical Reports Server (NTRS)

Malekpour, Mahyar R.; Stoughton, John W.; Mielke, Roland R.

1992-01-01

A software simulator capability of simulating execution of an algorithm graph on a given system under the Algorithm to Architecture Mapping Model (ATAMM) rules is presented. ATAMM is capable of modeling the execution of large-grained algorithms on distributed data flow architectures. Investigating the behavior and determining the performance of an ATAMM based system requires the aid of software tools. The ATAMM Simulator presented is capable of determining the performance of a system without having to build a hardware prototype. Case studies are performed on four algorithms to demonstrate the capabilities of the ATAMM Simulator. Simulated results are shown to be comparable to the experimental results of the Advanced Development Model System.

Look-ahead Dynamic Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

2015-10-20

Look-ahead dynamic simulation software system incorporates the high performance parallel computing technologies, significantly reduces the solution time for each transient simulation case, and brings the dynamic simulation analysis into on-line applications to enable more transparency for better reliability and asset utilization. It takes the snapshot of the current power grid status, functions in parallel computing the system dynamic simulation, and outputs the transient response of the power system in real time.

Dynamic system simulation of small satellite projects

NASA Astrophysics Data System (ADS)

Raif, Matthias; Walter, Ulrich; Bouwmeester, Jasper

2010-11-01

A prerequisite to accomplish a system simulation is to have a system model holding all necessary project information in a centralized repository that can be accessed and edited by all parties involved. At the Institute of Astronautics of the Technische Universitaet Muenchen a modular approach for modeling and dynamic simulation of satellite systems has been developed called dynamic system simulation (DySyS). DySyS is based on the platform independent description language SysML to model a small satellite project with respect to the system composition and dynamic behavior. A library of specific building blocks and possible relations between these blocks have been developed. From this library a system model of the satellite of interest can be created. A mapping into a C++ simulation allows the creation of an executable system model with which simulations are performed to observe the dynamic behavior of the satellite. In this paper DySyS is used to model and simulate the dynamic behavior of small satellites, because small satellite projects can act as a precursor to demonstrate the feasibility of a system model since they are less complex compared to a large scale satellite project.

Longitudinal train dynamics: an overview

NASA Astrophysics Data System (ADS)

Wu, Qing; Spiryagin, Maksym; Cole, Colin

2016-12-01

This paper discusses the evolution of longitudinal train dynamics (LTD) simulations, which covers numerical solvers, vehicle connection systems, air brake systems, wagon dumper systems and locomotives, resistance forces and gravitational components, vehicle in-train instabilities, and computing schemes. A number of potential research topics are suggested, such as modelling of friction, polymer, and transition characteristics for vehicle connection simulations, studies of wagon dumping operations, proper modelling of vehicle in-train instabilities, and computing schemes for LTD simulations. Evidence shows that LTD simulations have evolved with computing capabilities. Currently, advanced component models that directly describe the working principles of the operation of air brake systems, vehicle connection systems, and traction systems are available. Parallel computing is a good solution to combine and simulate all these advanced models. Parallel computing can also be used to conduct three-dimensional long train dynamics simulations.

An Interactive Teaching System for Bond Graph Modeling and Simulation in Bioengineering

ERIC Educational Resources Information Center

Roman, Monica; Popescu, Dorin; Selisteanu, Dan

2013-01-01

The objective of the present work was to implement a teaching system useful in modeling and simulation of biotechnological processes. The interactive system is based on applications developed using 20-sim modeling and simulation software environment. A procedure for the simulation of bioprocesses modeled by bond graphs is proposed and simulators…

Strategy and gaps for modeling, simulation, and control of hybrid systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rabiti, Cristian; Garcia, Humberto E.; Hovsapian, Rob

2015-04-01

The purpose of this report is to establish a strategy for modeling and simulation of candidate hybrid energy systems. Modeling and simulation is necessary to design, evaluate, and optimize the system technical and economic performance. Accordingly, this report first establishes the simulation requirements to analysis candidate hybrid systems. Simulation fidelity levels are established based on the temporal scale, real and synthetic data availability or needs, solution accuracy, and output parameters needed to evaluate case-specific figures of merit. Accordingly, the associated computational and co-simulation resources needed are established; including physical models when needed, code assembly and integrated solutions platforms, mathematical solvers,more » and data processing. This report first attempts to describe the figures of merit, systems requirements, and constraints that are necessary and sufficient to characterize the grid and hybrid systems behavior and market interactions. Loss of Load Probability (LOLP) and effective cost of Effective Cost of Energy (ECE), as opposed to the standard Levelized Cost of Electricty (LCOE), are introduced as technical and economical indices for integrated energy system evaluations. Financial assessment methods are subsequently introduced for evaluation of non-traditional, hybrid energy systems. Algorithms for coupled and iterative evaluation of the technical and economic performance are subsequently discussed. This report further defines modeling objectives, computational tools, solution approaches, and real-time data collection and processing (in some cases using real test units) that will be required to model, co-simulate, and optimize; (a) an energy system components (e.g., power generation unit, chemical process, electricity management unit), (b) system domains (e.g., thermal, electrical or chemical energy generation, conversion, and transport), and (c) systems control modules. Co-simulation of complex, tightly coupled, dynamic energy systems requires multiple simulation tools, potentially developed in several programming languages and resolved on separate time scales. Whereas further investigation and development of hybrid concepts will provide a more complete understanding of the joint computational and physical modeling needs, this report highlights areas in which co-simulation capabilities are warranted. The current development status, quality assurance, availability and maintainability of simulation tools that are currently available for hybrid systems modeling is presented. Existing gaps in the modeling and simulation toolsets and development needs are subsequently discussed. This effort will feed into a broader Roadmap activity for designing, developing, and demonstrating hybrid energy systems.« less

A Unique Software System For Simulation-to-Flight Research

NASA Technical Reports Server (NTRS)

Chung, Victoria I.; Hutchinson, Brian K.

2001-01-01

"Simulation-to-Flight" is a research development concept to reduce costs and increase testing efficiency of future major aeronautical research efforts at NASA. The simulation-to-flight concept is achieved by using common software and hardware, procedures, and processes for both piloted-simulation and flight testing. This concept was applied to the design and development of two full-size transport simulators, a research system installed on a NASA B-757 airplane, and two supporting laboratories. This paper describes the software system that supports the simulation-to-flight facilities. Examples of various simulation-to-flight experimental applications were also provided.

Simulating neural systems with Xyce.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schiek, Richard Louis; Thornquist, Heidi K.; Mei, Ting

2012-12-01

Sandias parallel circuit simulator, Xyce, can address large scale neuron simulations in a new way extending the range within which one can perform high-fidelity, multi-compartment neuron simulations. This report documents the implementation of neuron devices in Xyce, their use in simulation and analysis of neuron systems.

Construction of dynamic stochastic simulation models using knowledge-based techniques

NASA Technical Reports Server (NTRS)

Williams, M. Douglas; Shiva, Sajjan G.

1990-01-01

Over the past three decades, computer-based simulation models have proven themselves to be cost-effective alternatives to the more structured deterministic methods of systems analysis. During this time, many techniques, tools and languages for constructing computer-based simulation models have been developed. More recently, advances in knowledge-based system technology have led many researchers to note the similarities between knowledge-based programming and simulation technologies and to investigate the potential application of knowledge-based programming techniques to simulation modeling. The integration of conventional simulation techniques with knowledge-based programming techniques is discussed to provide a development environment for constructing knowledge-based simulation models. A comparison of the techniques used in the construction of dynamic stochastic simulation models and those used in the construction of knowledge-based systems provides the requirements for the environment. This leads to the design and implementation of a knowledge-based simulation development environment. These techniques were used in the construction of several knowledge-based simulation models including the Advanced Launch System Model (ALSYM).

Space shuttle visual simulation system design study

NASA Technical Reports Server (NTRS)

1973-01-01

A recommendation and a specification for the visual simulation system design for the space shuttle mission simulator are presented. A recommended visual system is described which most nearly meets the visual design requirements. The cost analysis of the recommended system covering design, development, manufacturing, and installation is reported. Four alternate systems are analyzed.

Modeling and simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanham, R.; Vogt, W.G.; Mickle, M.H.

1986-01-01

This book presents the papers given at a conference on computerized simulation. Topics considered at the conference included expert systems, modeling in electric power systems, power systems operating strategies, energy analysis, a linear programming approach to optimum load shedding in transmission systems, econometrics, simulation in natural gas engineering, solar energy studies, artificial intelligence, vision systems, hydrology, multiprocessors, and flow models.

Simulation System Fidelity Assessment at the Vertical Motion Simulator

NASA Technical Reports Server (NTRS)

Beard, Steven D.; Reardon, Scott E.; Tobias, Eric L.; Aponso, Bimal L.

2013-01-01

Fidelity is a word that is often used but rarely understood when talking about groundbased simulation. Assessing the cueing fidelity of a ground based flight simulator requires a comparison to actual flight data either directly or indirectly. Two experiments were conducted at the Vertical Motion Simulator using the GenHel UH-60A Black Hawk helicopter math model that was directly compared to flight data. Prior to the experiment the simulator s motion and visual system frequency responses were measured, the aircraft math model was adjusted to account for the simulator motion system delays, and the motion system gains and washouts were tuned for the individual tasks. The tuned motion system fidelity was then assessed against the modified Sinacori criteria. The first experiments showed similar handling qualities ratings (HQRs) to actual flight for a bob-up and sidestep maneuvers. The second experiment showed equivalent HQRs between flight and simulation for the ADS33 slalom maneuver for the two pilot participants. The ADS33 vertical maneuver HQRs were mixed with one pilot rating the flight and simulation the same while the second pilot rated the simulation worse. In addition to recording HQRs on the second experiment, an experimental Simulation Fidelity Rating (SFR) scale developed by the University of Liverpool was tested for applicability to engineering simulators. A discussion of the SFR scale for use on the Vertical Motion Simulator is included in this paper.

A Process for Comparing Dynamics of Distributed Space Systems Simulations

NASA Technical Reports Server (NTRS)

Cures, Edwin Z.; Jackson, Albert A.; Morris, Jeffery C.

2009-01-01

The paper describes a process that was developed for comparing the primary orbital dynamics behavior between space systems distributed simulations. This process is used to characterize and understand the fundamental fidelities and compatibilities of the modeling of orbital dynamics between spacecraft simulations. This is required for high-latency distributed simulations such as NASA s Integrated Mission Simulation and must be understood when reporting results from simulation executions. This paper presents 10 principal comparison tests along with their rationale and examples of the results. The Integrated Mission Simulation (IMSim) (formerly know as the Distributed Space Exploration Simulation (DSES)) is a NASA research and development project focusing on the technologies and processes that are related to the collaborative simulation of complex space systems involved in the exploration of our solar system. Currently, the NASA centers that are actively participating in the IMSim project are the Ames Research Center, the Jet Propulsion Laboratory (JPL), the Johnson Space Center (JSC), the Kennedy Space Center, the Langley Research Center and the Marshall Space Flight Center. In concept, each center participating in IMSim has its own set of simulation models and environment(s). These simulation tools are used to build the various simulation products that are used for scientific investigation, engineering analysis, system design, training, planning, operations and more. Working individually, these production simulations provide important data to various NASA projects.

Improvements to information management systems simulator

NASA Technical Reports Server (NTRS)

Bilek, R. W.

1972-01-01

The performance of personnel in the augmentation and improvement of the interactive IMSIM information management simulation model is summarized. With this augmented model, NASA now has even greater capabilities for the simulation of computer system configurations, data processing loads imposed on these configurations, and executive software to control system operations. Through these simulations, NASA has an extremely cost effective capability for the design and analysis of computer-based data management systems.

The Australian Computational Earth Systems Simulator

NASA Astrophysics Data System (ADS)

Mora, P.; Muhlhaus, H.; Lister, G.; Dyskin, A.; Place, D.; Appelbe, B.; Nimmervoll, N.; Abramson, D.

2001-12-01

Numerical simulation of the physics and dynamics of the entire earth system offers an outstanding opportunity for advancing earth system science and technology but represents a major challenge due to the range of scales and physical processes involved, as well as the magnitude of the software engineering effort required. However, new simulation and computer technologies are bringing this objective within reach. Under a special competitive national funding scheme to establish new Major National Research Facilities (MNRF), the Australian government together with a consortium of Universities and research institutions have funded construction of the Australian Computational Earth Systems Simulator (ACcESS). The Simulator or computational virtual earth will provide the research infrastructure to the Australian earth systems science community required for simulations of dynamical earth processes at scales ranging from microscopic to global. It will consist of thematic supercomputer infrastructure and an earth systems simulation software system. The Simulator models and software will be constructed over a five year period by a multi-disciplinary team of computational scientists, mathematicians, earth scientists, civil engineers and software engineers. The construction team will integrate numerical simulation models (3D discrete elements/lattice solid model, particle-in-cell large deformation finite-element method, stress reconstruction models, multi-scale continuum models etc) with geophysical, geological and tectonic models, through advanced software engineering and visualization technologies. When fully constructed, the Simulator aims to provide the software and hardware infrastructure needed to model solid earth phenomena including global scale dynamics and mineralisation processes, crustal scale processes including plate tectonics, mountain building, interacting fault system dynamics, and micro-scale processes that control the geological, physical and dynamic behaviour of earth systems. ACcESS represents a part of Australia's contribution to the APEC Cooperation for Earthquake Simulation (ACES) international initiative. Together with other national earth systems science initiatives including the Japanese Earth Simulator and US General Earthquake Model projects, ACcESS aims to provide a driver for scientific advancement and technological breakthroughs including: quantum leaps in understanding of earth evolution at global, crustal, regional and microscopic scales; new knowledge of the physics of crustal fault systems required to underpin the grand challenge of earthquake prediction; new understanding and predictive capabilities of geological processes such as tectonics and mineralisation.

Winter Simulation Conference, Miami Beach, Fla., December 4-6, 1978, Proceedings. Volumes 1 & 2

NASA Technical Reports Server (NTRS)

Highland, H. J. (Editor); Nielsen, N. R.; Hull, L. G.

1978-01-01

The papers report on the various aspects of simulation such as random variate generation, simulation optimization, ranking and selection of alternatives, model management, documentation, data bases, and instructional methods. Simulation studies in a wide variety of fields are described, including system design and scheduling, government and social systems, agriculture, computer systems, the military, transportation, corporate planning, ecosystems, health care, manufacturing and industrial systems, computer networks, education, energy, production planning and control, financial models, behavioral models, information systems, and inventory control.

Design of penicillin fermentation process simulation system

NASA Astrophysics Data System (ADS)

Qi, Xiaoyu; Yuan, Zhonghu; Qi, Xiaoxuan; Zhang, Wenqi

2011-10-01

Real-time monitoring for batch process attracts increasing attention. It can ensure safety and provide products with consistent quality. The design of simulation system of batch process fault diagnosis is of great significance. In this paper, penicillin fermentation, a typical non-linear, dynamic, multi-stage batch production process, is taken as the research object. A visual human-machine interactive simulation software system based on Windows operation system is developed. The simulation system can provide an effective platform for the research of batch process fault diagnosis.