Systemic aspects of conjugal resilience in couples with a child facing cancer and marrow transplantation.

PubMed

Martin, Julie; Péloquin, Katherine; Vachon, Marie-France; Duval, Michel; Sultan, Serge

The negative impact of paediatric cancer on parents is well known and is even greater when intensive treatments are used. This study aimed to describe how couples whose child has received a transplant for the treatment of leukaemia view conjugal resilience and to evaluate the role of we-ness as a precursor of conjugal adjustment. Four parental couples were interviewed. Interviews were analysed in two ways: inductive thematic analysis and rating of verbal content with the We-ness Coding Scale . Participants report that conjugal resilience involves the identification of the couple as a team and cohesion in the couple. Being a team generates certain collaborative interactions that lead to conjugal resilience. A sense of we-ness in parents is associated with fluctuation in the frequency of themes. Participants' vision of conjugal resilience introduced novel themes. The sense of we-ness facilitates cohesion and the process of conjugal resilience.

Non-equilibrium steady states in supramolecular polymerization

NASA Astrophysics Data System (ADS)

Sorrenti, Alessandro; Leira-Iglesias, Jorge; Sato, Akihiro; Hermans, Thomas M.

2017-06-01

Living systems use fuel-driven supramolecular polymers such as actin to control important cell functions. Fuel molecules like ATP are used to control when and where such polymers should assemble and disassemble. The cell supplies fresh ATP to the cytosol and removes waste products to sustain steady states. Artificial fuel-driven polymers have been developed recently, but keeping them in sustained non-equilibrium steady states (NESS) has proven challenging. Here we show a supramolecular polymer that can be kept in NESS, inside a membrane reactor where ATP is added and waste removed continuously. Assembly and disassembly of our polymer is regulated by phosphorylation and dephosphorylation, respectively. Waste products lead to inhibition, causing the reaction cycle to stop. Inside the membrane reactor, however, waste can be removed leading to long-lived NESS conditions. We anticipate that our approach to obtain NESS can be applied to other stimuli-responsive materials to achieve more life-like behaviour.

Nonequilibrium Saturation States and Fractional Kinetic Processes In The Turbulent Magnetotail

NASA Astrophysics Data System (ADS)

Milovanov, A. V.; Zelenyi, L. M.

Magnetotail regions with the considerably stretched and thinned magnetic lobe field offer a fertile playground for studying the fundamental properties of the self-organized turbulent systems. The focus of this report is on the turbulent nonequilibrium satu- ration states (NESS's) of the tail, where the plasma strongly couples with the self- organized magnetic and inductive electric fields. We advocate an unconventional de- scription of the NESS's, which brings together the ideas of fractal geometry, topology of manifolds, and fractional ("strange") kinetics. A self-consistent nonlinear fractional kinetic equation is proposed for the particle dynamics near the marginal NESS. We ar- gue that the inherent variability of the NESS is manifest in the low-frequency fluctu- ation spectrum f-1 often referred to as "flicker noise". The self-consistent plasma distribution function at the NESS is shown to reveal a power-law nonthermal tail (E) E-, where the slope 6 7 depends on the type of the spatiotem- poral correlations in the medium. Basic theoretical predictions are discussed against observations. This study was sponsored by the INTAS project 97-1612 and RFBR grants 00-02-17127 and 00-15-96631.

A second perspective on the Amann-Schmiedl-Seifert criterion for non-equilibrium in a three-state system

NASA Astrophysics Data System (ADS)

Jia, Chen; Chen, Yong

2015-05-01

In the work of Amann, Schmiedl and Seifert (2010 J. Chem. Phys. 132 041102), the authors derived a sufficient criterion to identify a non-equilibrium steady state (NESS) in a three-state Markov system based on the coarse-grained information of two-state trajectories. In this paper, we present a mathematical derivation and provide a probabilistic interpretation of the Amann-Schmiedl-Seifert (ASS) criterion. Moreover, the ASS criterion is compared with some other criterions for a NESS.

Optimization under uncertainty of parallel nonlinear energy sinks

NASA Astrophysics Data System (ADS)

Boroson, Ethan; Missoum, Samy; Mattei, Pierre-Olivier; Vergez, Christophe

2017-04-01

Nonlinear Energy Sinks (NESs) are a promising technique for passively reducing the amplitude of vibrations. Through nonlinear stiffness properties, a NES is able to passively and irreversibly absorb energy. Unlike the traditional Tuned Mass Damper (TMD), NESs do not require a specific tuning and absorb energy over a wider range of frequencies. Nevertheless, they are still only efficient over a limited range of excitations. In order to mitigate this limitation and maximize the efficiency range, this work investigates the optimization of multiple NESs configured in parallel. It is well known that the efficiency of a NES is extremely sensitive to small perturbations in loading conditions or design parameters. In fact, the efficiency of a NES has been shown to be nearly discontinuous in the neighborhood of its activation threshold. For this reason, uncertainties must be taken into account in the design optimization of NESs. In addition, the discontinuities require a specific treatment during the optimization process. In this work, the objective of the optimization is to maximize the expected value of the efficiency of NESs in parallel. The optimization algorithm is able to tackle design variables with uncertainty (e.g., nonlinear stiffness coefficients) as well as aleatory variables such as the initial velocity of the main system. The optimal design of several parallel NES configurations for maximum mean efficiency is investigated. Specifically, NES nonlinear stiffness properties, considered random design variables, are optimized for cases with 1, 2, 3, 4, 5, and 10 NESs in parallel. The distributions of efficiency for the optimal parallel configurations are compared to distributions of efficiencies of non-optimized NESs. It is observed that the optimization enables a sharp increase in the mean value of efficiency while reducing the corresponding variance, thus leading to more robust NES designs.

NESS06SM reduces body weight with an improved profile relative to SR141716A.

PubMed

Mastinu, Andrea; Pira, Marilena; Pinna, Gérard Aimè; Pisu, Carla; Casu, Maria Antonietta; Reali, Roberta; Marcello, Stefania; Murineddu, Gabriele; Lazzari, Paolo

2013-08-01

We have recently synthesized a new series of 4,5-dihydrobenzo-oxa-cycloheptapyrazole derivatives with the aim to discover novel CB1 antagonist agents characterized by anti-obesity activity comparable to that of SR141716A but with reduced adverse effects such as anxiety and depression. Within the novel class, the CB1 antagonist 8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-4,5-dihydrobenzo-1H-6-oxa-cyclohepta(1,2-c)pyrazole-3-carboxamide (NESS06SM) has been selected as lead compound. We found that NESS06SM is a CB1 neutral antagonist, characterized by poor blood-brain barrier permeability. Moreover, NESS06SM chronic treatment determined both anti-obesity effect and cardiovascular risk factor improvement in C57BL/6N Diet Induced Obesity (DIO) mice fed with fat diet (FD mice). In fact, the mRNA gene expression in Central Nervous System (CNS) and peripheral tissues by real time PCR, showed a significant increase of orexigenic peptides and a decrease of anorexigenic peptides elicited by NESS06SM treatment, compared to control mice fed with the same diet. Moreover, in contrast to SR141716A treatment, the chronic administration of NESS06SM did not change mRNA expression of both monoaminergic transporters and neurotrophins highly related with anxiety and mood disorders. Our results suggest that NESS06SM reduces body weight and it can restore the disrupted expression profile of genes linked to the hunger-satiety circuit without altering monoaminergic transmission probably avoiding SR141716A side effects. Therefore the novel CB1 neutral antagonist could represent a useful candidate agent for the treatment of obesity and its metabolic complications. Copyright © 2013 Elsevier Ltd. All rights reserved.

Predicting eczema severity beyond childhood.

PubMed

Hon, Kam Lun; Tsang, Yin-Ching K; Poon, Terence Chuen W; Pong, Nga Hin; Kwan, Matthew; Lau, Shirley; Chiu, Yuen-Chun; Wong, Hin-Hei; Leung, Ting-Fan

2016-02-01

We evaluated factors associated with eczema severity in adolescence. Nottingham Eczema Severity Score (NESS), family and personal history of atopy, skin prick test for common food and aeroallergens, highest serum IgE level and eosinophil count were evaluated. Patients with paired NESSs (childhood-NESS is NESS performed at <10 years of age; adolescence-NESS is NESS performed at age >10 years) were further analyzed. Adolescence-NESS (n=383 patients) was associated with eczema onset in infancy, dust mite and food allergen sensitization, dietary avoidance, use of wet wrap, traditional Chinese medicine, immunomodulant (azathioprine or cyclosporine), high IgE level, eosinophil count, but not with family/personal history of atopy. Eighty-two patients had both childhood-NESS and adolescence-NESS (mean follow-up of 6.8 years) showing that adolescence-NESS was associated with childhood- NESS severity grades (P=0.034). Of these patients, 48% remained in the same severity grades, whereas 39% improved, and 13% deteriorated from childhood to adolescence. It is not possible to assure parents that their child can outgrow eczema. In eczema prognosis research, long-term follow-up is warranted.

Nonequilibrium Steady State Generated by a Moving Defect: The Supersonic Threshold

NASA Astrophysics Data System (ADS)

Bastianello, Alvise; De Luca, Andrea

2018-02-01

We consider the dynamics of a system of free fermions on a 1D lattice in the presence of a defect moving at constant velocity. The defect has the form of a localized time-dependent variation of the chemical potential and induces at long times a nonequilibrium steady state (NESS), which spreads around the defect. We present a general formulation that allows recasting the time-dependent protocol in a scattering problem on a static potential. We obtain a complete characterization of the NESS. In particular, we show a strong dependence on the defect velocity and the existence of a sharp threshold when such velocity exceeds the speed of sound. Beyond this value, the NESS is not produced and, remarkably, the defect travels without significantly perturbing the system. We present an exact solution for a δ -like defect traveling with an arbitrary velocity and we develop a semiclassical approximation that provides accurate results for smooth defects.

Systemic aspects of conjugal resilience in couples with a child facing cancer and marrow transplantation

PubMed Central

Martin, Julie; Péloquin, Katherine; Vachon, Marie-France; Duval, Michel; Sultan, Serge

2016-01-01

Introduction The negative impact of paediatric cancer on parents is well known and is even greater when intensive treatments are used. This study aimed to describe how couples whose child has received a transplant for the treatment of leukaemia view conjugal resilience and to evaluate the role of we-ness as a precursor of conjugal adjustment. Methods Four parental couples were interviewed. Interviews were analysed in two ways: inductive thematic analysis and rating of verbal content with the We-ness Coding Scale. Results Participants report that conjugal resilience involves the identification of the couple as a team and cohesion in the couple. Being a team generates certain collaborative interactions that lead to conjugal resilience. A sense of we-ness in parents is associated with fluctuation in the frequency of themes. Discussion Participants’ vision of conjugal resilience introduced novel themes. The sense of we-ness facilitates cohesion and the process of conjugal resilience. PMID:27687510

Probabilistic evaluation of uncertainties and risks in aerospace components

NASA Technical Reports Server (NTRS)

Shah, A. R.; Shiao, M. C.; Nagpal, V. K.; Chamis, C. C.

1992-01-01

A methodology is presented for the computational simulation of primitive variable uncertainties, and attention is given to the simulation of specific aerospace components. Specific examples treated encompass a probabilistic material behavior model, as well as static, dynamic, and fatigue/damage analyses of a turbine blade in a mistuned bladed rotor in the SSME turbopumps. An account is given of the use of the NESSES probabilistic FEM analysis CFD code.

Exploring Social Equity Aspects in Integrating Technology in Primary Mathematics Education

ERIC Educational Resources Information Center

Stoilescu, Dorian

2014-01-01

This research focus on aspects of equity related to the introduction of using technology in classrooms. Technology has the potential to support mathematics pedagogy with visual representations and offer modelling and simulation facilities, increasing the creativity of the learning and teaching processes (Kaput, Ness, & Hoyles, 2008; Stoilescu…

Coding "We-ness" in couple's relationship stories: A method for assessing mutuality in couple therapy.

PubMed

Gildersleeve, Sara; Singer, Jefferson A; Skerrett, Karen; Wein, Shelter

2017-05-01

"We-ness," a couple's mutual investment in their relationship and in each other, has been found to be a potent dimension of couple resilience. This study examined the development of a method to capture We-ness in psychotherapy through the coding of relationship narratives co-constructed by couples ("We-Stories"). It used a coding system to identify the core thematic elements that make up these narratives. Couples that self-identified as "happy" (N = 53) generated We-Stories and completed measures of relationship satisfaction and mutuality. These stories were then coded using the We-Stories coding manual. Findings indicated that security, an element that involves aspects of safety, support, and commitment, was most common, appearing in 58.5% of all narratives. This element was followed by the elements of pleasure (49.1%) and shared meaning/vision (37.7%). The number of "We-ness" elements was also correlated with and predictive of discrepancy scores on measures of relationship mutuality, indicating the validity of the We-Stories coding manual. Limitations and future directions are discussed.

Stochastic theory of nonequilibrium steady states and its applications. Part I

NASA Astrophysics Data System (ADS)

Zhang, Xue-Juan; Qian, Hong; Qian, Min

2012-01-01

The concepts of equilibrium and nonequilibrium steady states are introduced in the present review as mathematical concepts associated with stationary Markov processes. For both discrete stochastic systems with master equations and continuous diffusion processes with Fokker-Planck equations, the nonequilibrium steady state (NESS) is characterized in terms of several key notions which are originated from nonequilibrium physics: time irreversibility, breakdown of detailed balance, free energy dissipation, and positive entropy production rate. After presenting this NESS theory in pedagogically accessible mathematical terms that require only a minimal amount of prerequisites in nonlinear differential equations and the theory of probability, it is applied, in Part I, to two widely studied problems: the stochastic resonance (also known as coherent resonance) and molecular motors (also known as Brownian ratchet). Although both areas have advanced rapidly on their own with a vast amount of literature, the theory of NESS provides them with a unifying mathematical foundation. Part II of this review contains applications of the NESS theory to processes from cellular biochemistry, ranging from enzyme catalyzed reactions, kinetic proofreading, to zeroth-order ultrasensitivity.

The operational processing of wind estimates from cloud motions: Past, present and future

NASA Technical Reports Server (NTRS)

Novak, C.; Young, M.

1977-01-01

Current NESS winds operations provide approximately 1800 high quality wind estimates per day to about twenty domestic and foreign users. This marked improvement in NESS winds operations was the result of computer techniques development which began in 1969 to streamline and improve operational procedures. In addition, the launch of the SMS-1 satellite in 1974, the first in the second generation of geostationary spacecraft, provided an improved source of visible and infrared scanner data for the extraction of wind estimates. Currently, operational winds processing at NESS is accomplished by the automated and manual analyses of infrared data from two geostationary spacecraft. This system uses data from SMS-2 and GOES-1 to produce wind estimates valid for 00Z, 12Z and 18Z synoptic times.

Nonequilibrium steady state in open quantum systems: Influence action, stochastic equation and power balance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsiang, J.-T., E-mail: cosmology@gmail.com; Department of Physics, National Dong Hwa University, Hualien 97401, Taiwan; Hu, B.L.

2015-11-15

The existence and uniqueness of a steady state for nonequilibrium systems (NESS) is a fundamental subject and a main theme of research in statistical mechanics for decades. For Gaussian systems, such as a chain of classical harmonic oscillators connected at each end to a heat bath, and for classical anharmonic oscillators under specified conditions, definitive answers exist in the form of proven theorems. Answering this question for quantum many-body systems poses a challenge for the present. In this work we address this issue by deriving the stochastic equations for the reduced system with self-consistent backaction from the two baths, calculatingmore » the energy flow from one bath to the chain to the other bath, and exhibiting a power balance relation in the total (chain + baths) system which testifies to the existence of a NESS in this system at late times. Its insensitivity to the initial conditions of the chain corroborates to its uniqueness. The functional method we adopt here entails the use of the influence functional, the coarse-grained and stochastic effective actions, from which one can derive the stochastic equations and calculate the average values of physical variables in open quantum systems. This involves both taking the expectation values of quantum operators of the system and the distributional averages of stochastic variables stemming from the coarse-grained environment. This method though formal in appearance is compact and complete. It can also easily accommodate perturbative techniques and diagrammatic methods from field theory. Taken all together it provides a solid platform for carrying out systematic investigations into the nonequilibrium dynamics of open quantum systems and quantum thermodynamics. -- Highlights: •Nonequilibrium steady state (NESS) for interacting quantum many-body systems. •Derivation of stochastic equations for quantum oscillator chain with two heat baths. •Explicit calculation of the energy flow from one bath to the chain to the other bath. •Power balance relation shows the existence of NESS insensitive to initial conditions. •Functional method as a viable platform for issues in quantum thermodynamics.« less

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

DOE PAGES

Fung, Ho Yee Joyce; Fu, Szu -Chin; Brautigam, Chad A.; ...

2015-09-08

The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure. The plasticity of the CRM1-NES interaction is not well understood, as there are many NES sequences that seem incompatible with structures of the NES-bound CRM1 groove. Crystal structures of CRM1 bound to two different NESs with unusual sequences showed the NES peptides binding the CRM1 groove in the opposite orientation (minus) to that of previously studied NESs (plus). A comparison of minus and plus NESs identified structural and sequencemore » determinants for NES orientation. The binding of NESs to CRM1 in both orientations results in a large expansion in NES consensus patterns and therefore a corresponding expansion of potential NESs in the proteome.« less

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

PubMed

Güttler, Thomas; Madl, Tobias; Neumann, Piotr; Deichsel, Danilo; Corsini, Lorenzo; Monecke, Thomas; Ficner, Ralf; Sattler, Michael; Görlich, Dirk

2010-11-01

Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs. These NESs differ markedly in the spacing of their key hydrophobic (Φ) residues, yet CRM1 recognizes them with the same rigid set of five Φ pockets. The different Φ spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an α-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Φ pocket. NMR analyses of CRM1-bound and CRM1-free PKI NES suggest that CRM1 selects NES conformers that pre-exist in solution. Our data lead to a new structure-based NES consensus, and explain why NESs differ in their affinities for CRM1 and why supraphysiological NESs bind the exportin so tightly.

Sequence and structural analyses of nuclear export signals in the NESdb database

PubMed Central

Xu, Darui; Farmer, Alicia; Collett, Garen; Grishin, Nick V.; Chook, Yuh Min

2012-01-01

We compiled >200 nuclear export signal (NES)–containing CRM1 cargoes in a database named NESdb. We analyzed the sequences and three-dimensional structures of natural, experimentally identified NESs and of false-positive NESs that were generated from the database in order to identify properties that might distinguish the two groups of sequences. Analyses of amino acid frequencies, sequence logos, and agreement with existing NES consensus sequences revealed strong preferences for the Φ1-X3-Φ2-X2-Φ3-X-Φ4 pattern and for negatively charged amino acids in the nonhydrophobic positions of experimentally identified NESs but not of false positives. Strong preferences against certain hydrophobic amino acids in the hydrophobic positions were also revealed. These findings led to a new and more precise NES consensus. More important, three-dimensional structures are now available for 68 NESs within 56 different cargo proteins. Analyses of these structures showed that experimentally identified NESs are more likely than the false positives to adopt α-helical conformations that transition to loops at their C-termini and more likely to be surface accessible within their protein domains or be present in disordered or unobserved parts of the structures. Such distinguishing features for real NESs might be useful in future NES prediction efforts. Finally, we also tested CRM1-binding of 40 NESs that were found in the 56 structures. We found that 16 of the NES peptides did not bind CRM1, hence illustrating how NESs are easily misidentified. PMID:22833565

TIMP3 Promoter Methylation Represents an Epigenetic Marker of BRCA1ness Breast Cancer Tumours.

PubMed

Maleva Kostovska, Ivana; Jakimovska, Milena; Popovska-Jankovic, Katerina; Kubelka-Sabit, Katerina; Karagjozov, Mitko; Plaseska-Karanfilska, Dijana

2018-03-09

Tumours presenting BRCAness profile behave more aggressively and are more invasive as a consequence of their complex genetic and epigenetic alterations, caused by impaired fidelity of the DNA repair processes. Methylation of promoter CpG islands represents an alternative mechanism to inactivate DNA repair and tumour suppressor genes. In our study, we analyzed the frequency of methylation changes of 24 tumour suppressor genes and explored their association with BRCAness profile. BRCA1ness profile and aberrant methylation were studied in 233 fresh frozen breast tumour tissues by Multiplex Ligation-dependent Probe Amplification (MLPA) and Methylation Specific (MS)-MLPA methods, respectively. Our analyses revealed that 12.4% of the breast cancer (BC) patients had tumours with a BRCA1ness profile. TIMP3 showed significantly higher (p = 5.8х10 -5 ) methylation frequency in tumours with BRCA1ness, while methylation of APC, GSTP1 and RASSF1 promoters was negatively associated with BRCA1ness (р = 0.0017, р = 0.007 and р = 0.046, respectively). TIMP3 methylation was also associated with triple negative (TN) BC. Furthermore, TN tumours showing BRCA1ness showed stronger association with TIMP3 methylation (p = 0.0008) in comparison to TN tumours without BRCA1ness (p = 0.009). In conclusion, we confirmed that TIMP3 methylation is a marker for TN tumours and furthermore we showed for the first time that TIMP3 promoter methylation is an epigenetic marker of BRCA1ness tumours.

Spirit-ness at Work: Connections between Workplace Spirituality, Transformative Learning, and Social Justice

ERIC Educational Resources Information Center

Tolliver, Derise E.

2016-01-01

The workplace is a place where we show up as human beings, subject to human experience. People are no longer willing to leave their spirit-ness at the door. In reality, spirit-ness shows up "without permission" as a revolutionary, powerful, and transformative way of being in a world that too often supports status quo activities that are…

Quantum entanglement at high temperatures? Bosonic systems in nonequilibrium steady state

NASA Astrophysics Data System (ADS)

Hsiang, Jen-Tsung; Hu, B. L.

2015-11-01

This is the second of a series of three papers examining how viable it is for entanglement to be sustained at high temperatures for quantum systems in thermal equilibrium (Case A), in nonequilibrium (Case B) and in nonequilibrium steady state (NESS) conditions (Case C). The system we analyze here consists of two coupled quantum harmonic oscillators each interacting with its own bath described by a scalar field, set at temperatures T 1 > T 2. For constant bilinear inter-oscillator coupling studied here (Case C1) owing to the Gaussian nature, the problem can be solved exactly at arbitrary temperatures even for strong coupling. We find that the valid entanglement criterion in general is not a function of the bath temperature difference, in contrast to thermal transport in the same NESS setting [1]. Thus lowering the temperature of one of the thermal baths does not necessarily help to safeguard the entanglement between the oscillators. Indeed, quantum entanglement will disappear if any one of the thermal baths has a temperature higher than the critical temperature T c, defined as the temperature above which quantum entanglement vanishes. With the Langevin equations derived we give a full display of how entanglement dynamics in this system depends on T 1, T 2, the inter-oscillator coupling and the system-bath coupling strengths. For weak oscillator-bath coupling the critical temperature T c is about the order of the inverse oscillator frequency, but for strong oscillator-bath coupling it will depend on the bath cutoff frequency. We conclude that in most realistic circumstances, for bosonic systems in NESS with constant bilinear coupling, `hot entanglement' is largely a fiction.

Prehospital Emergency Inguinal Clamp Controls Hemorrhage in Cadaver Model

DTIC Science & Technology

2013-07-01

fit at anatomic pressure points needed in hemorrhage control. The CRoC was placed on trauma manikins at the U.S. Army Med- ical Department Center and...simulant was pumped to quantify device effective- ness in testing. Points of application included proximal pressure point control of popliteal...a casualty’s wound from the point of injury on the battlefield to the emergency department has been impractical; so a device was made to replace the

Updating the TSP Quality Plan Using Monte Carlo Simulation

DTIC Science & Technology

2010-08-01

TSP is the attention to quality or, more accurately, the ability to manage product defects. In fact, TSP creator Watts S . Humphrey says: ... defect...teams at Hill AFB recently started using this technique and are still gathering data on its useful- ness.u References 1. Humphrey , Watts S . TSP...Leading a Development Team. Upper Saddle River, NJ: Addison-Wesley, 2006. Page 138. 2. Humphrey , Watts S . TSP – Leading a Development Team. Upper Saddle

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.

PubMed

Fung, Ho Yee Joyce; Fu, Szu-Chin; Chook, Yuh Min

2017-03-10

Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015). Here, we show crystal structures of CRM1 bound to eight additional NESs which reveal diverse conformations that range from loop-like to all-helix, which occupy different extents of the invariant NES-binding groove. Analysis of all NES structures show 5-6 distinct backbone conformations where the only conserved secondary structural element is one turn of helix that binds the central portion of the CRM1 groove. All NESs also participate in main chain hydrogen bonding with human CRM1 Lys568 side chain, which acts as a specificity filter that prevents binding of non-NES peptides. The large conformational range of NES backbones explains the lack of a fixed pattern for its 3-5 hydrophobic anchor residues, which in turn explains the large array of peptide sequences that can function as NESs.

NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile.

PubMed

Mastinu, Andrea; Pira, Marilena; Pani, Luca; Pinna, Gérard Aimè; Lazzari, Paolo

2012-10-01

The present work aims to study the effects induced by a chronic treatment with a novel CB1 antagonist (NESS038C6) in C57BL/6N diet-induced obesity (DIO) mice. Mice treated with NESS038C6 and fed with a fat diet (NESS038C6 FD) were compared with the following three reference experimental groups: DIO mice fed with the same fat diet used for NESS038C6 and treated with vehicle or the reference CB1 antagonist/inverse agonist rimonabant, "VH FD" and "SR141716 FD", respectively; DIO mice treated with vehicle and switched to a normal diet (VH ND). NESS038C6 chronic treatment (30 mg/kg/day for 31 days) determined a significant reduction in DIO mice weight relative to that of VH FD. The entity of the effect was comparable to that detected in both SR141716 FD and VH ND groups. Moreover, if compared to VH FD, NESS038C6 FD evidenced: (i) improvement of cardiovascular risk factors; (ii) significant decrease in adipose tissue leptin expression; (iii) increase in mRNA expression of hypothalamic orexigenic peptides and a decrease of anorexigenic peptides; (iv) expression increase of metabolic enzymes and peroxisome proliferator-activated receptor-α in the liver; (v) normalization of monoaminergic transporters and neurotrophic expression in mesolimbic area. However, in contrast to the case of rimonabant, the novel CB1 antagonist improved the disrupted expression profile of genes linked to the hunger-satiety circuit, without altering monoaminergic transmission. In conclusion, the novel CB1 antagonist compound NESS038C6 may represent a useful candidate agent for the treatment of obesity and its metabolic complications, without or with reduced side effects relative to those instead observed with rimonabant. Copyright © 2012 Elsevier B.V. All rights reserved.

Mimicking Nonequilibrium Steady States with Time-Periodic Driving

NASA Astrophysics Data System (ADS)

Raz, O.; Subaşı, Y.; Jarzynski, C.

2016-04-01

Under static conditions, a system satisfying detailed balance generically relaxes to an equilibrium state in which there are no currents. To generate persistent currents, either detailed balance must be broken or the system must be driven in a time-dependent manner. A stationary system that violates detailed balance evolves to a nonequilibrium steady state (NESS) characterized by fixed currents. Conversely, a system that satisfies instantaneous detailed balance but is driven by the time-periodic variation of external parameters—also known as a stochastic pump (SP)—reaches a periodic state with nonvanishing currents. In both cases, these currents are maintained at the cost of entropy production. Are these two paradigmatic scenarios effectively equivalent? For discrete-state systems, we establish a mapping between nonequilibrium stationary states and stochastic pumps. Given a NESS characterized by a particular set of stationary probabilities, currents, and entropy production rates, we show how to construct a SP with exactly the same (time-averaged) values. The mapping works in the opposite direction as well. These results establish a proof of principle: They show that stochastic pumps are able to mimic the behavior of nonequilibrium steady states, and vice versa, within the theoretical framework of discrete-state stochastic thermodynamics. Nonequilibrium steady states and stochastic pumps are often used to model, respectively, biomolecular motors driven by chemical reactions and artificial molecular machines steered by the variation of external, macroscopic parameters. Our results loosely suggest that anything a biomolecular machine can do, an artificial molecular machine can do equally well. We illustrate this principle by showing that kinetic proofreading, a NESS mechanism that explains the low error rates in biochemical reactions, can be effectively mimicked by a constrained periodic driving.

Nanowire Electron Scattering Spectroscopy

NASA Technical Reports Server (NTRS)

Hunt, Brian; Bronikowsky, Michael; Wong, Eric; VonAllmen, Paul; Oyafuso, Fablano

2009-01-01

Nanowire electron scattering spectroscopy (NESS) has been proposed as the basis of a class of ultra-small, ultralow-power sensors that could be used to detect and identify chemical compounds present in extremely small quantities. State-of-the-art nanowire chemical sensors have already been demonstrated to be capable of detecting a variety of compounds in femtomolar quantities. However, to date, chemically specific sensing of molecules using these sensors has required the use of chemically functionalized nanowires with receptors tailored to individual molecules of interest. While potentially effective, this functionalization requires labor-intensive treatment of many nanowires to sense a broad spectrum of molecules. In contrast, NESS would eliminate the need for chemical functionalization of nanowires and would enable the use of the same sensor to detect and identify multiple compounds. NESS is analogous to Raman spectroscopy, the main difference being that in NESS, one would utilize inelastic scattering of electrons instead of photons to determine molecular vibrational energy levels. More specifically, in NESS, one would exploit inelastic scattering of electrons by low-lying vibrational quantum states of molecules attached to a nanowire or nanotube.

Wave transmission through silicone foam pads in a compression Kolsky bar apparatus. Comparisons between simulations and measurements.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corona, Edmundo; Song, Bo

This memo concerns the transmission of mechanical signals through silicone foam pads in a compression Kolsky bar set-up. The results of numerical simulations for four levels of pad pre-compression and two striker velocities were compared directly to test measurements to assess the delity of the simulations. The nite element model simulated the Kolsky tests in their entirety and used the hyperelastic `hyperfoam' model for the silicone foam pads. Calibration of the hyperfoam model was deduced from quasi-static compression data. It was necessary, however, to augment the material model by adding sti ness proportional damping in order to generate results thatmore » resembled the experimental measurements. Based on the results presented here, it is important to account for the dynamic behavior of polymeric foams in numerical simulations that involve high loading rates.« less

78 FR 27415 - Kansas; Major Disaster and Related Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

..., McPherson, Ness, Osage, Osborne, Pawnee, Phillips, Pratt, Rice, Rooks, Rush, Russell, Smith, and Stafford..., McPherson, Ness, Osage, Osborne, Pawnee, Phillips, Pratt, Rice, Rooks, Rush, Russell, Smith, and Stafford...

Estimation of Anonymous Email Network Characteristics through Statistical Disclosure Attacks

PubMed Central

Portela, Javier; García Villalba, Luis Javier; Silva Trujillo, Alejandra Guadalupe; Sandoval Orozco, Ana Lucila; Kim, Tai-Hoon

2016-01-01

Social network analysis aims to obtain relational data from social systems to identify leaders, roles, and communities in order to model profiles or predict a specific behavior in users’ network. Preserving anonymity in social networks is a subject of major concern. Anonymity can be compromised by disclosing senders’ or receivers’ identity, message content, or sender-receiver relationships. Under strongly incomplete information, a statistical disclosure attack is used to estimate the network and node characteristics such as centrality and clustering measures, degree distribution, and small-world-ness. A database of email networks in 29 university faculties is used to study the method. A research on the small-world-ness and Power law characteristics of these email networks is also developed, helping to understand the behavior of small email networks. PMID:27809275

Estimation of Anonymous Email Network Characteristics through Statistical Disclosure Attacks.

PubMed

Portela, Javier; García Villalba, Luis Javier; Silva Trujillo, Alejandra Guadalupe; Sandoval Orozco, Ana Lucila; Kim, Tai-Hoon

2016-11-01

Social network analysis aims to obtain relational data from social systems to identify leaders, roles, and communities in order to model profiles or predict a specific behavior in users' network. Preserving anonymity in social networks is a subject of major concern. Anonymity can be compromised by disclosing senders' or receivers' identity, message content, or sender-receiver relationships. Under strongly incomplete information, a statistical disclosure attack is used to estimate the network and node characteristics such as centrality and clustering measures, degree distribution, and small-world-ness. A database of email networks in 29 university faculties is used to study the method. A research on the small-world-ness and Power law characteristics of these email networks is also developed, helping to understand the behavior of small email networks.

On Paperless-ness.

ERIC Educational Resources Information Center

Campbell, Neil A.

1984-01-01

Focusing on F. W. Lancaster's prediction that paperless communication systems are inevitable for science and technology, this article presents an analysis of role of editorial processing centers (EPC) in the development of electronic journals. The traditional scientific journal, the EPC, and the EPC and electronic journal are discussed. (60…

Ryan M. Ness | NREL

Science.gov Websites

Interests Ryan M. Ness is a research technician in the Biomass Analysis group within the National Renewable , wet chemical analysis, and instrumental analysis of lignocellulosic biomass feedstocks. Bench-scale Publications "The Effect of Biomass Densification on Structural Sugar Release and Yield in Biofuel

Society and Scientific Anomalies: Common Knowledge about the Loch Ness Monster.

ERIC Educational Resources Information Center

Bauer, Henry H.

1987-01-01

Surveys newspaper, magazine, and book literature about the Loch Ness monster from 1933 to 1983. Characterizes the literature by attitude, length, belief, and jocularity. Illuminates the problem of identifying demarcation criteria for what may be classed as science and as pseudoscience. (CW)

Analysis and prediction of leucine-rich nuclear export signals.

PubMed

la Cour, Tanja; Kiemer, Lars; Mølgaard, Anne; Gupta, Ramneek; Skriver, Karen; Brunak, Søren

2004-06-01

We present a thorough analysis of nuclear export signals and a prediction server, which we have made publicly available. The machine learning prediction method is a significant improvement over the generally used consensus patterns. Nuclear export signals (NESs) are extremely important regulators of the subcellular location of proteins. This regulation has an impact on transcription and other nuclear processes, which are fundamental to the viability of the cell. NESs are studied in relation to cancer, the cell cycle, cell differentiation and other important aspects of molecular biology. Our conclusion from this analysis is that the most important properties of NESs are accessibility and flexibility allowing relevant proteins to interact with the signal. Furthermore, we show that not only the known hydrophobic residues are important in defining a nuclear export signals. We employ both neural networks and hidden Markov models in the prediction algorithm and verify the method on the most recently discovered NESs. The NES predictor (NetNES) is made available for general use at http://www.cbs.dtu.dk/.

Engine System Model Development for Nuclear Thermal Propulsion

NASA Technical Reports Server (NTRS)

Nelson, Karl W.; Simpson, Steven P.

2006-01-01

In order to design, analyze, and evaluate conceptual Nuclear Thermal Propulsion (NTP) engine systems, an improved NTP design and analysis tool has been developed. The NTP tool utilizes the Rocket Engine Transient Simulation (ROCETS) system tool and many of the routines from the Enabler reactor model found in Nuclear Engine System Simulation (NESS). Improved non-nuclear component models and an external shield model were added to the tool. With the addition of a nearly complete system reliability model, the tool will provide performance, sizing, and reliability data for NERVA-Derived NTP engine systems. A new detailed reactor model is also being developed and will replace Enabler. The new model will allow more flexibility in reactor geometry and include detailed thermal hydraulics and neutronics models. A description of the reactor, component, and reliability models is provided. Another key feature of the modeling process is the use of comprehensive spreadsheets for each engine case. The spreadsheets include individual worksheets for each subsystem with data, plots, and scaled figures, making the output very useful to each engineering discipline. Sample performance and sizing results with the Enabler reactor model are provided including sensitivities. Before selecting an engine design, all figures of merit must be considered including the overall impacts on the vehicle and mission. Evaluations based on key figures of merit of these results and results with the new reactor model will be performed. The impacts of clustering and external shielding will also be addressed. Over time, the reactor model will be upgraded to design and analyze other NTP concepts with CERMET and carbide fuel cores.

The role of childhood trauma, early maladaptive schemas, emotional schemas and experimental avoidance on depression: A structural equation modeling.

PubMed

Rezaei, Mehdi; Ghazanfari, Firoozeh; Rezaee, Fatemeh

2016-12-30

The present investigation was designed to examine disconnection and rejection (DR) schemas, negative emotional schemas (NESs) and experimental avoidance (EA) as mediating variables of the relationship between the childhood trauma (CT) and depression. Specifically we examined the mediating role of NESs and EA between DR schemas and depression. The study sample consist of 439 female college students (M age =22.47; SD=6.0), of whom 88 met the criteria for current major depressive disorder (MDD) and 351 who had history of MDD in the last 12 months. Subjects were assessed by Structured Clinical Interview for DSM-IV (SCID) and completed the Childhood Trauma Questionnaire (CTQ), the Early Maladaptive Schemas Questionnaire (SQ-SF), the Leahy Emotional Schemas Scale (LESS), the Acceptance and Action Questionnaire (AAQ-II), and the Beck Depression Inventory-II (BDI-II). The findings showed that DR schemas were mediator of the relationship CT and depression but CT through the NESs and EA did not predict depression. NESs were mediator of the relationship between DR schemas and depression and EA was mediator of the relationship between DR schemas and depression. In general, results suggest that intervention of depressed women may need to target the changing of DR schemas, NESs and reduction of EA. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Environmental Compliance Assessment System (ECAS) - Oregon Supplement

DTIC Science & Technology

1994-04-01

m2 square meter yd yard m 3 cubic meter ys 2 square yard mg milligram yd3 cubic yard mi 1inc yr year lag microgram JAm micrometer 4lPa micropascals...Wilderness, Strawberry Mountain Wilder- ness, Diamond Peak Wilderness, Crater Lake National Park, Kalmiopsis Wilderness, Mountain Lake Wilderness, and

The Promise of English. NCTE 1970 Distinguished Lectures.

ERIC Educational Resources Information Center

National Council of Teachers of English, Champaign, IL.

The essays in this book point out an unhappiness with existent forms of English teaching and emphasize possibilities for a future in which the human-ness and humane-ness of literary, linguistic, and writing experiences will be encouraged. Authors and papers are (1) Louise M. Rosenblatt, "Literature and the Invisible Reader"; (2) Muriel Crosby,…

Nonequilibrium steady states and resonant tunneling in time-periodically driven systems with interactions

NASA Astrophysics Data System (ADS)

Qin, Tao; Hofstetter, Walter

2018-03-01

Time-periodically driven systems are a versatile toolbox for realizing interesting effective Hamiltonians. Heating, caused by excitations to high-energy states, is a challenge for experiments. While most setups so far address the relatively weakly interacting regime, it is of general interest to study heating in strongly correlated systems. Using Floquet dynamical mean-field theory, we study nonequilibrium steady states (NESS) in the Falicov-Kimball model, with time-periodically driven kinetic energy or interaction. We systematically investigate the nonequilibrium properties of the NESS. For a driven kinetic energy, we show that resonant tunneling, where the interaction is an integer multiple of the driving frequency, plays an important role in the heating. In the strongly correlated regime, we show that this can be well understood using Fermi's golden rule and the Schrieffer-Wolff transformation for a time-periodically driven system. We furthermore demonstrate that resonant tunneling can be used to control the population of Floquet states to achieve "photodoping." For driven interactions introduced by an oscillating magnetic field near a widely adopted Feshbach resonance, we find that the double occupancy is strongly modulated. Our calculations apply to shaken ultracold-atom systems and to solid-state systems in a spatially uniform but time-dependent electric field. They are also closely related to lattice modulation spectroscopy. Our calculations are helpful to understand the latest experiments on strongly correlated Floquet systems.

A case study of the sensitivity of forecast skill to data and data analysis techniques

NASA Technical Reports Server (NTRS)

Baker, W. E.; Atlas, R.; Halem, M.; Susskind, J.

1983-01-01

A series of experiments have been conducted to examine the sensitivity of forecast skill to various data and data analysis techniques for the 0000 GMT case of January 21, 1979. These include the individual components of the FGGE observing system, the temperatures obtained with different satellite retrieval methods, and the method of vertical interpolation between the mandatory pressure analysis levels and the model sigma levels. It is found that NESS TIROS-N infrared retrievals seriously degrade a rawinsonde-only analysis over land, resulting in a poorer forecast over North America. Less degradation in the 72-hr forecast skill at sea level and some improvement at 500 mb is noted, relative to the control with TIROS-N retrievals produced with a physical inversion method which utilizes a 6-hr forecast first guess. NESS VTPR oceanic retrievals lead to an improved forecast over North America when added to the control.

AFTOMS Technology Issues and Alternatives Report

DTIC Science & Technology

1989-12-01

color , resolu- power requirements, physi- tion; memory , processor speed; cal and weather rugged- IAN interfaces, etc,) f,: these ness. display...Telephone and Telegraph 3 CD-I Compact Disk - Interactive CD-ROM Compact Disk-Read Only Memory CGM Computer Graphics Metafile CNWDI Critical Nuclear...Database Management System RFP Request For Proposal 3 RFS Remote File System ROM Read Only Memory 3 S SA-ALC San Antonio Air Logistics Center 3 SAC

In a World of "Us-ness"

ERIC Educational Resources Information Center

Pratapchandran, Sarat

2009-01-01

In the morning when a child walks into a classroom, he should feel a sense of belonging. In simple terms, this defines the world of "us-ness," a concept that noted educator and new media expert, Professor Stephen Heppell says plays the most important part in designing a new learning facility. Heppell advocates a critical assessment of the needs of…

The Near-Earth Space Surveillance (NESS) Mission: Discovery, Tracking, and Characterization of Asteroids, Comets, and Artificial Satellites with a Microsatellite

NASA Technical Reports Server (NTRS)

Hildebrand, A. R.; Carroll, K. A.; Balam, D. D.; Cardinal, R. D.; Matthews, J. M.; Kuschnig, R.; Walker, G. A. H.; Brown, P. G.; Tedesco, E. F.; Worden, S. P.

2001-01-01

The Near-Earth Space Surveillance (NESS) Mission, a microsatellite dedicated to observing near-Earth (NEO) and interior-to-the-Earth (IEO)asteroids and comets plus artificial satellites, is currently being studied under contract to the Canadian Space Agency. Additional information is contained in the original extended abstract.

A Preliminary Study: USMC Tactical Communications Technical Control Needs for the Landing Force Integrated Communications System.

DTIC Science & Technology

1985-09-01

BSTRACT This study uses a systems analysis approach to determine the communications technical control needs of the Fleet Marine Force as the transition...subsequent analysis and decision. In the acquisi- tion of military systems, it is typical to find these assumptions used to construct various measures of...relatively free from the typical underlying estimates used in cost and operational effective- ness analysis (COEA) type studies which are designed to compare

VizieR Online Data Catalog: The Cannon: a new approach to determine masses (Ness+, 2016)

NASA Astrophysics Data System (ADS)

Ness, M.; Hogg, D. W.; Rix, H.-W.; Martig, M.; Pinsonneault, M. H.; Ho, A. Y. Q.

2016-08-01

We make use of The Cannon (Ness et al. 2015, J/ApJ/808/16), which is a data-driven method for determining stellar parameters and abundances (see section 2.1 for further explanations). APOGEE is a Sloan Digital Sky Survey (SDSS) (Eisenstein et al. 2011AJ....142...72E) infrared survey of the Milky Way disk, bulge, and halo and has provided H-band spectra (1500-1700nm) of about 150000 stars in the public data release DR12. The three labels of Teff, logg, and [Fe/H] delivered with The Cannon were demonstrated in Ness et al. (2015, J/ApJ/808/16). In this work we train on and then determine two additional labels: [α/Fe] and mass. (1 data file).

Hyper IgE in Childhood Eczema and Risk of Asthma in Chinese Children.

PubMed

Ng, Chantel; Hon, Kam Lun; Kung, Jeng Sum Charmaine; Pong, Nga Hin; Leung, Ting-Fan; Wong, Chun Kwok

2016-06-10

Atopic eczema is a common childhood disease associated with high IgE and eosinophilia. We characterized the clinical features associated with hyper-IgE (defined as IgE > 2000 IU/L) in eczema. Nottingham Eczema Severity Score (NESS), family and personal history of atopy, skin prick test (SPT) for common food and aeroallergens, highest serum IgE ever and eosinophil counts were evaluated in 330 children eczema patients. Childhood-NESS (NESS performed at <10 years of age) and adolescent-NESS (NESS performed at >10 years of age) were further analyzed. IgE correlated with NESS (spearman coefficient 0.35, p < 0.001) and eosinophil percentage (spearman coefficient 0.56, p = 0.001). Compared with IgE ≤ 2000IU/L (n = 167), patients with hyper-IgE (n = 163) were associated with male gender (p = 0.002); paternal atopy (p = 0.026); personal history of atopic rhinitis (p = 0.016); asthma (p < 0.001); dietary avoidance (p < 0.001); use of wet wrap (p < 0.001); traditional Chinese medicine use (TCM, p < 0.001); immunomodulant use (azathioprine or cyclosporine, p < 0.001); skin prick sensitization by dust mites (p < 0.001), cats (p = 0.012), dogs (p = 0.018), food (p = 0.002); eosinophilia (p < 0.001); more severe disease during childhood (p < 0.0001) and during adolescence (p < 0.0001), but not onset age of eczema or maternal atopy. Logistic regression showed that hyper-IgE was associated with personal history of asthma (exp(B) = 5.12, p = 0.002) and eczema severity during childhood and adolescence (p < 0.001). For patients <10 years of age, dust mite sensitization (p = 0.008) was associated with hyper-IgE. For patients >10years of age, food allergen sensitization was associated with hyper-IgE (p = 0.008). Hyper-IgE is independently associated with asthma, more severe atopy and more severe eczema during childhood and adolescence. IgE > 2000 IU/L may be a tool to aid prognostication of this chronic relapsing dermatologic disease and its progression to asthma.

TREC 2013 Web Track Overview

DTIC Science & Technology

2014-01-30

tradeoffs systems can achieve between effectiveness (overall gains across queries) and robustness (minimizing the probability of significant failure...by multiple users; less than 10 terms in length; and relatively low effective - ness scores across multiple commercial search engines (as of January...appear in the judgment (qrels) file. These relevance grades are also used for calculating graded effectiveness measures, except that a value of -2 is

Enterovirus and Parechovirus Surveillance - United States, 2014-2016.

PubMed

Abedi, Glen R; Watson, John T; Nix, W Allan; Oberste, M Steven; Gerber, Susan I

2018-05-11

Infections caused by enteroviruses (EV) and parechoviruses (PeV), members of the Picornaviridae family, are associated with various clinical manifestations, including hand, foot, and mouth disease; respiratory illness; myocarditis; meningitis; and sepsis; and can result in death. The genus Enterovirus includes four species of enterovirus (A-D) known to infect humans, and the genus Parechovirus includes one species (A) that infects humans. These species are further divided into types, some of which are associated with specific clinical manifestations. During 2014-2016, a total of 2,967 U.S. cases of EV and PeV infections were reported to the National Enterovirus Surveillance System (NESS). The largest number of reports during that time (2,051) occurred in 2014, when a large nationwide outbreak of enterovirus D68 (EV-D68) occurred, accounting for 68% of cases reported to NESS that year (1). Reports to the National Respiratory and Enteric Virus Surveillance System (NREVSS) during 2014-2016 indicated that circulation of EV peaks annually in the summer and early fall. Because the predominant types of EV and PeV circulating from year to year tend to vary, tracking these trends requires consistent and complete reports from laboratories with the capacity to perform typing.

Snow extent measurements from geostationary satellites using an interactive computer system. [Salt and Verde River Basins, Arizona

NASA Technical Reports Server (NTRS)

Gird, R. S. (Principal Investigator)

1980-01-01

The author has identified the following significant results. A time series of GOES full resolution visible image sectors was viewed on the McIDAS video component in chronological order and registered to within plus or minus 1 image pixel to compute real time snow melting rates. Synoptic scale clouds were eliminated to create a snow covered area from a composite image. Results show good agreement with NESS products although a significant difference was noted for one two-day period when the NESS products showed an increase in the snow cover for the Verde Basin, while the GOES/McIDAS product implied no change in the snow cover for approximately the same period. A check of NWS radar reports indicated no precipitation had occurred within the Verde basin. The use of the registered image sequence eliminates instrument error since small changes in the snow cover between any two days are easily detected.

Erich Fromm and Universal Humane Experience: Application in the Aesthetic Domain for Art Educators. Technical Paper No. 39

ERIC Educational Resources Information Center

Fisher, R. Michael

2012-01-01

Recent re-reading of Erich Fromm's (1968) "The Revolution of Hope," has proven to be compatible with an aesthetic model (A-ness/D-ness) that I have been researching on and developing in the past 30 years. Fromm's call for a radical humanistic agenda, if not revolution, was appealing to my own call for a radical aesthetic and art education agenda…

Shape optimization of electrostatically driven microcantilevers using simulated annealing to enhance static travel range

NASA Astrophysics Data System (ADS)

Trivedi, R. R.; Joglekar, M. M.; Shimpi, R. P.; Pawaskar, D. N.

2013-12-01

The objective of this paper is to present a systematic development of the generic shape optimization of elec- trostatically actuated microcantilever beams for extending their static travel range. Electrostatic actuators are widely used in micro electro mechanical system (MEMS) devices because of low power density and ease of fab- rication. However, their useful travel range is often restricted by a phenomenon known as pull-in instability. The Rayleigh- Ritz energy method is used for computation of pull-in parameters which includes electrostatic potential and fringing field effect. Appropriate width function and linear thickness functions are employed along the length of the non-prismatic beam to achieve enhanced travel range. Parameters used for varying the thick- ness and width functions are optimized using simulated annealing with pattern search method towards the end to refine the results. Appropriate penalties are imposed on the violation of volume, width, thickness and area constraints. Nine test cases are considered for demonstration of the said optimization method. Our results indicate that around 26% increase in the travel range of a non-prismatic beam can be achieved after optimiza- tion compared to that in a prismatic beam having the same volume. Our results also show an improvement in the pull-in displacement of around 5% compared to that of a variable width constant thickness actuator. We show that simulated annealing is an effective and flexible method to carry out design optimization of structural elements under electrostatic loading.

Doing Business with Words: Performative Aspects of Deontic Systems

DTIC Science & Technology

1986-04-01

location. If we do not have the possibility of preserving an object, a perforrative doc- arent , that represents the ccrmunication act, we shall have tc find...formation of induce- ments. The bottom level consists of the substantive norms, the ones expressed directly in terms of the men , machines, materials, 50...Loqic, D. Reidel, Dordrecht. Kimbrough, S.O, R.M. Lee and D.N.Ness, 1984. "Perfonrative, Infortative and Emotive Systems - The First Piece of the PIE", in

JPRS Report, Soviet Union, International Affairs.

DTIC Science & Technology

1987-11-27

becoming very relevant in this connection. One direct consequence is the need for closer interaction not only of the technical and production potential... personal computers, systems for numeric programmed control for functional machine tools and flexible produc- tion modules, programmable master... personality of the collective director— his enterprising nature, his ability to work in a new way (or his willing- ness to learn). "Even today many

Survey: National Environmental Satellite Service

NASA Technical Reports Server (NTRS)

1977-01-01

The national Environmental Satellite Service (NESS) receives data at periodic intervals from satellites of the Synchronous Meteorological Satellite/Geostationary Operational Environmental Satellite series and from the Improved TIROS (Television Infrared Observational Satellite) Operational Satellite. Within the conterminous United States, direct readout and processed products are distributed to users over facsimile networks from a central processing and data distribution facility. In addition, the NESS Satellite Field Stations analyze, interpret, and distribute processed geostationary satellite products to regional weather service activities.

Extreme river flow dependence in Northern Scotland

NASA Astrophysics Data System (ADS)

Villoria, M. Franco; Scott, M.; Hoey, T.; Fischbacher-Smith, D.

2012-04-01

Various methods for the spatial analysis of hydrologic data have been developed recently. Here we present results using the conditional probability approach proposed by Keef et al. [Appl. Stat. (2009): 58,601-18] to investigate spatial interdependence in extreme river flows in Scotland. This approach does not require the specification of a correlation function, being mostly suitable for relatively small geographical areas. The work is motivated by the Flood Risk Management Act (Scotland (2009)) which requires maps of flood risk that take account of spatial dependence in extreme river flow. The method is based on two conditional measures of spatial flood risk: firstly the conditional probability PC(p) that a set of sites Y = (Y 1,...,Y d) within a region C of interest exceed a flow threshold Qp at time t (or any lag of t), given that in the specified conditioning site X > Qp; and, secondly the expected number of sites within C that will exceed a flow Qp on average (given that X > Qp). The conditional probabilities are estimated using the conditional distribution of Y |X = x (for large x), which can be modeled using a semi-parametric approach (Heffernan and Tawn [Roy. Statist. Soc. Ser. B (2004): 66,497-546]). Once the model is fitted, pseudo-samples can be generated to estimate functionals of the joint tails of the distribution of (Y,X). Conditional return level plots were directly compared to traditional return level plots thus improving our understanding of the dependence structure of extreme river flow events. Confidence intervals were calculated using block bootstrapping methods (100 replicates). We report results from applying this approach to a set of four rivers (Dulnain, Lossie, Ewe and Ness) in Northern Scotland. These sites were chosen based on data quality, spatial location and catchment characteristics. The river Ness, being the largest (catchment size 1839.1km2) was chosen as the conditioning river. Both the Ewe (441.1km2) and Ness catchments have predominantly impermeable bedrock, with the Ewe's one being very wet. The Lossie(216km2) and Dulnain (272.2km2) both contain significant areas of glacial deposits. River flow in the Dulnain is usually affected by snowmelt. In all cases, the conditional probability of each of the three rivers (Dulnain, Lossie, Ewe) decreases as the event in the conditioning river (Ness) becomes more extreme. The Ewe, despite being the furthest of the three sites from the Ness shows the strongest dependence, with relatively high (>0.4) conditional probabilities even for very extreme events (>0.995). Although the Lossie is closer geographically to the Ness than the Ewe, it shows relatively low conditional probabilities and can be considered independent of the Ness for very extreme events (> 0.990). The conditional probabilities seem to reflect the different catchment characteristics and dominant precipitation generating events, with the Ewe being more similar to the Ness than the other two rivers. This interpretation suggests that the conditional method may yield improved estimates of extreme events, but the approach is time consuming. An alternative model that is easier to implement, using a spatial quantile regression, is currently being investigated, which would also allow the introduction of further covariates, essential as the effects of climate change are incorporated into estimation procedures.

High Sensitivity, One-Sided X-Ray Inspection System.

DTIC Science & Technology

1985-07-01

8217. X-Ray Imaging Quantitative NDT One-Sided Inspection Backs cat ter De laminat ions .. Nondestructive Testing (NDT) Rocket Motor Case NDT ’j 20...epoxy composites and other low atomic number materials have been detected. Wall thick nesses up to 7 cm thick have been interrogated. The results show...fiber composite rocket motor pressure vessels, the anticipated backscatter x-ray instrument will offer high sensitivity (contact delaminations have

Sleep Deprivation and Sustained Attention Performance: Integrating Mathematical and Cognitive Modeling

DTIC Science & Technology

2009-01-01

Gluck,a David F. Dingesc aAir Force Research Laboratory, Mesa bThe Pennsylvania State University , University Park cUniversity of Pennsylvania School...possible using either model- ing approach in isolation. 2.1. Biomathematical models of alertness Biomathematical models of alertness have been developed...window into the information process- ing mechanisms in the cognitive system and how they may be affected by decreased alert- ness. The next section

Finding user personal interests by tweet-mining using advanced machine learning algorithm in R

NASA Astrophysics Data System (ADS)

Krithika, L. B.; Roy, P.; Asha Jerlin, M.

2017-11-01

The social-media plays a key role in every individual’s life by anyone’s personal views about their liking-ness/disliking-ness. This methodology is a sharp departure from the traditional techniques of inferring interests of a user from the tweets that he/she posts or receives. It is showed that the topics of interest inferred by the proposed methodology are far superior than the topics extracted by state-of-the-art techniques such as using topic models (Labelled LDA) on tweets. Based upon the proposed methodology, a system has been built, “Who is interested in what”, which can infer the interests of millions of Twitter users. A novel mechanism is proposed to infer topics of interest of individual users in the twitter social network. It has been observed that in twitter, a user generally follows experts on various topics of his/her interest in order to acquire information on those topics. A methodology based on social annotations is used to first deduce the topical expertise of popular twitter users and then transitively infer the interests of the users who follow them.

Regulation of the Drosophila Hypoxia-Inducible Factor α Sima by CRM1-Dependent Nuclear Export ▿

PubMed Central

Romero, Nuria M.; Irisarri, Maximiliano; Roth, Peggy; Cauerhff, Ana; Samakovlis, Christos; Wappner, Pablo

2008-01-01

Hypoxia-inducible factor α (HIF-α) proteins are regulated by oxygen levels through several different mechanisms that include protein stability, transcriptional coactivator recruitment, and subcellular localization. It was previously reported that these transcription factors are mainly nuclear in hypoxia and cytoplasmic in normoxia, but so far the molecular basis of this regulation is unclear. We show here that the Drosophila melanogaster HIF-α protein Sima shuttles continuously between the nucleus and the cytoplasm. We identified the relevant nuclear localization signal and two functional nuclear export signals (NESs). These NESs are in the Sima basic helix-loop-helix (bHLH) domain and promote CRM1-dependent nuclear export. Site-directed mutagenesis of either NES provoked Sima nuclear retention and increased transcriptional activity, suggesting that nuclear export contributes to Sima regulation. The identified NESs are conserved and probably functional in the bHLH domains of several bHLH-PAS proteins. We propose that rapid nuclear export of Sima regulates the duration of cellular responses to hypoxia. PMID:18332128

From mimesis to agency: clinical steps in the work of psychic two-ness.

PubMed

Busch de Ahumada, Luisa C; Ahumada, Jorge L

2005-06-01

In this paper, through the study of the clinical process of a girl starting treatment at the age of 3 years 10 months, who was thought of as a 'dummy' by her family and who came for consultation when the assumed genetic aetiology was questioned, the authors build upon Tustin's contributions on the context of togetherness and the crisis of two-ness, and upon Eugenio and Renata Gaddini's on the precursor object. The mimetic phenomena enacted with an older brother and at the kindergarten are found to result from cumulative trauma at her contacting a loving but mind-blind mother. After an initial stage of transference autism, enactment in the session of the traumatic situation was the ?rst step in surmounting her autistic pseudo-stupidity. Mimetic transference dynamics took place principally at the level of the gaze, leading to the unfolding of the work of two-ness to a differentiation from the analyst as psychic breast, on the road to symbol formation and personal agency.

Dismantling reified African culture through localised homosexualities in Uganda.

PubMed

Nyanzi, Stella

2013-01-01

Uganda's Anti-Homosexuality Bill of 2009 aimed at protecting the cherished culture of the people against emergent threats to the traditional heterosexual family. The Bill's justification, however, lay in myopic imaginings of a homogenous African-ness and pedestrian oblivion to pluralities within African sexualities. This paper revisits the debate that homosexuality is 'un-African'. Rhetoric analysis of the Anti-Homosexuality Bill exposes how dominant discourses of law, medicine, religion, geography and culture reinforce the view that homosexuality is foreign to Africa. Based on ethnography in contemporary Uganda, I explore how self-identified same-sex-loving individuals simultaneously claim their African-ness and their homosexuality. Their strategies include ethnic belonging, membership to kinship structures, making connections with pre-colonial histories of homosexuality, civic participation in democratic processes, national identity, organising of lesbian, gay, bisexual, transgender, intersex and questioning support groups, language and nomenclature, visibility and voice in local communal activities, solidarity and adherence to cultural rituals. In present-day Uganda, same-sex-loving men, women and transgender people variously assert their African-ness.

South African-ness Among Adolescents: The Emergence of a Collective Identity within the Birth to Twenty Cohort Study

PubMed Central

Norris, Shane A; Roeser, Robert W.; Richter, Linda M; Lewin, Nina; Ginsburg, Carren; Fleetwood, Stella A; Taole, Elizabeth; van der Wolf, Kees

2009-01-01

We assessed the emergence of a South African identity among Black, Colored (mixed ancestral origin), White (predominantly English speaking), and Indian adolescents participating in a birth cohort study called “Birth to Twenty” in Johannesburg, South Africa. We examined young people's certainty of their self-categorization as South African, the centrality of their personal, racial and linguistic, and South African identities in their self-definition, and their perceptions of South African life and society today. These results reflect a historical opportunity for full citizenship and national enfranchisement that the end of Apartheid heralded for Black and Colored individuals. Black and Colored youth tend to be more certain about their South African-ness, have a more collective identity, and have a more positive perception around South Africa. In contrast, White and Indian youth are less certain about their South African-ness, have a more individualistic identity, and have a less positive perception about South Africa today. PMID:19461896

Flow Distribution Control Characteristics in Marine Gas Turbine Waste- Heat Recovery Systems. Phase 2. Flow Distribution Control in Waste-Heat Steam Generators

DTIC Science & Technology

1982-07-01

waste-heat steam generators. The applicable steam generator design concepts and general design consideration were reviewed and critical problems...a once-through forced-circulation steam generator design should be selected because of stability, reliability, compact- ness and lightweight...consists of three sections and one appendix. In Section I, the applicable steam generator design conccpts and general design * considerations are reviewed

Low earth orbiting Nadir Etalon Sounding Spectrometer instrument concept for temperature, moisture and trace species, LeoNESS

NASA Technical Reports Server (NTRS)

Kumer, J. B.; Sterritt, L. W.; Roche, A. E.; Rosenberg, W. J.; Morrow, H. E.; Shenk, W. E.; Susskind, J.

1992-01-01

A concept for a low earth orbiting nadir etalon spectrometer sounder (LeoNESS) is described which can achieve retrieval of temperature, H2O, surface, boundary conditions, cloudiness, and trace species with an accuracy that meets or exceeds the AIRS specifications. Options employing 65-K and 30-K detectors are examined; the former may be implemented via passive radiative cooling. The concept, which is derived from the Cryogenic Limb Array Etalon Spectrometer, has the potential for improving the horizontal and vertical resolution.

RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer

PubMed Central

Kulkarni, Madhura; Tan, Tuan Zea; Syed Sulaiman, Nurfarhanah Bte; Lamar, John M.; Bansal, Prashali; Cui, Jianzhou; Qiao, Yiting; Ito, Yoshiaki

2018-01-01

Hippo pathway target, YAP has emerged as an important player in solid tumor progression. Here, we identify RUNX1 and RUNX3 as novel negative regulators of oncogenic function of YAP in the context of breast cancer. RUNX proteins are one of the first transcription factors identified to interact with YAP. RUNX1 or RUNX3 expression abrogates YAP-mediated pro-tumorigenic properties of mammary epithelial cell lines in an interaction dependent manner. RUNX1 and RUNX3 inhibit YAP-mediated migration and stem-ness properties of mammary epithelial cell lines by co-regulating YAP-mediated gene expression. Analysis of whole genome expression profiles of breast cancer samples revealed significant co-relation between YAP–RUNX1/RUNX3 expression levels and survival outcomes of breast cancer patients. High RUNX1/RUNX3 expression proved protective towards YAP-dependent patient survival outcomes. High YAP in breast cancer patients’ expression profiles co-related with EMT and stem-ness gene signature enrichment. High RUNX1/RUNX3 expression along with high YAP reflected lower enrichment of EMT and stem-ness signatures. This antagonistic activity of RUNX1 and RUNX3 towards oncogenic function of YAP identified in mammary epithelial cells as well as in breast cancer expression profiles gives a novel mechanistic insight into oncogene–tumor suppressor interplay in the context of breast cancer progression. The novel interplay between YAP, RUNX1 and RUNX3 and its significance in breast cancer progression can serve as a prognostic tool to predict cancer recurrence. PMID:29581836

Influence of cultivar and of conventional and organic agricultural practices on phenolic and sensory profile of blackberries (Rubus fruticosus).

PubMed

Pinto, Teresa; Vilela, Alice; Pinto, Andreia; Nunes, Fernando M; Cosme, Fernanda; Anjos, Rosário

2018-03-06

Consumer demand for organic products is increasing because of their claimed health benefits. Blackberries are a rich source of polyphenols, with high antioxidant activity; nevertheless, the impact of organic versus conventional agricultural practices on its phytochemical composition is unknown. 'Loch Ness' and 'Chester Thornless' were selected as blackberry cultivars for this study because of their desired sensory and technological properties, which make them more suitable for export. 'Loch Ness' variety presented a higher amounts of polyphenols and higher antioxidant activity when compared to the 'Chester Thornless' variety. The impact of agricultural practices on the phytochemical composition of the two varieties was contradictory. Under organic agricultural practices, levels of polyphenols increased for 'Loch Ness' and decreased for 'Chester Thornless', whereas the soluble solids content increased in both varieties. These changes in composition were correlated with changes observed in the blackberries' sensory profile. The effect of agricultural practices on the blackberries' chemical and sensory profile was dependent on the variety and cannot be generalized. © 2018 Society of Chemical Industry. © 2018 Society of Chemical Industry.

We can work it out: age differences in relational pronouns, physiology, and behavior in marital conflict.

PubMed

Seider, Benjamin H; Hirschberger, Gilad; Nelson, Kristin L; Levenson, Robert W

2009-09-01

This study examined the relationship that personal pronouns spoken during a marital conversation have with the emotional qualities of those interactions and with marital satisfaction. Middle-aged and older couples (N = 154) engaged in a 15-min conflict conversation during which physiology and emotional behavior were continuously monitored. Verbatim transcripts of the conversations were coded into 2 lexical categories: (a) we-ness (we-words), pronouns that focus on the couple; (b) separateness (me/you-words), pronouns that focus on the individual spouses. Analyses revealed that greater we-ness was associated with a number of desirable qualities of the interaction (lower cardiovascular arousal, more positive and less negative emotional behavior), whereas greater separateness was associated with a less desirable profile (more negative emotional behavior, lower marital satisfaction). In terms of age differences, older couples used more we-ness words than did middle-aged couples. Further, the associations between separateness and marital satisfaction were strongest for older wives. These findings indicate that the emotional aspects of marital quality are expressed in the natural language of couples engaged in conversation. (c) 2009 APA, all rights reserved.

We can work it out: Age differences in relational pronouns, physiology, and behavior in marital conflict

PubMed Central

Seider, Benjamin H.; Hirschberger, Gilad; Nelson, Kristin L.; Levenson, Robert W.

2009-01-01

This study examined the relationship that personal pronouns spoken during a marital conversation have with the emotional qualities of those interactions and with marital satisfaction. Middle-aged and older couples (N=154) engaged in a 15-minute conflict conversation during which physiology and emotional behavior were continuously monitored. Verbatim transcripts of the conversations were coded into two lexical categories: (a) We-ness (we-words): pronouns that focus on the couple; (b) Separateness (Me/You words): pronouns that focus on the individual spouses. Analyses revealed that greater We-ness was associated with a number of desirable qualities of the interaction (lower cardiovascular arousal, more positive and less negative emotional behavior), whereas, greater Separateness was associated with a less desirable profile (more negative emotional behavior, lower marital satisfaction). In terms of age differences, older couples used more We-ness than middle-aged couples. Further, the associations between Separateness and marital satisfaction were strongest for older wives. These findings indicate that the emotional aspects of marital quality are expressed in the natural language of couples engaged in conversation. PMID:19739916

Associations between Relational Pronoun Usage and the Quality of Early Family Interactions.

PubMed

Galdiolo, Sarah; Roskam, Isabelle; Verhofstadt, Lesley L; De Mol, Jan; Dewinne, Laura; Vandaudenard, Sylvain

2016-01-01

Our study examined the relationships of relational pronouns used in parental conversation to the quality of early family interactions, as indexed by Family Alliance (FA). We hypothesized that more positive family interactions were associated with the use of more we-pronouns (e.g., we, us, our; we-ness ) and fewer I- and you-pronouns (e.g., I, me, you, your; separateness ) by both mothers and fathers. Our statistical model using a multilevel modeling framework and two levels of analysis (i.e., a couple level and an individual level) was tested on 47 non-referred families ( n = 31 primiparous families; child's age, M = 15.75 months, SD = 2.73) with we-ness and separateness as outcomes and FA functions as between-dyads variables. Analyses revealed that we-ness within the parental couple was only positively associated with family affect sharing while separateness was negatively associated with different FA functions (e.g., communication mistakes). Our main finding suggested that the kinds of personal pronouns used by parental couples when discussing children's education would be associated to the emotional quality of the family interactions.

Associations between Relational Pronoun Usage and the Quality of Early Family Interactions

PubMed Central

Galdiolo, Sarah; Roskam, Isabelle; Verhofstadt, Lesley L.; De Mol, Jan; Dewinne, Laura; Vandaudenard, Sylvain

2016-01-01

Our study examined the relationships of relational pronouns used in parental conversation to the quality of early family interactions, as indexed by Family Alliance (FA). We hypothesized that more positive family interactions were associated with the use of more we-pronouns (e.g., we, us, our; we-ness) and fewer I- and you-pronouns (e.g., I, me, you, your; separateness) by both mothers and fathers. Our statistical model using a multilevel modeling framework and two levels of analysis (i.e., a couple level and an individual level) was tested on 47 non-referred families (n = 31 primiparous families; child’s age, M = 15.75 months, SD = 2.73) with we-ness and separateness as outcomes and FA functions as between-dyads variables. Analyses revealed that we-ness within the parental couple was only positively associated with family affect sharing while separateness was negatively associated with different FA functions (e.g., communication mistakes). Our main finding suggested that the kinds of personal pronouns used by parental couples when discussing children’s education would be associated to the emotional quality of the family interactions. PMID:27847495

Computerized Biophysical Data Acquisition System for Motion Sickness Studies.

DTIC Science & Technology

1984-12-01

biofeedback in Autogenic Feedback Training (AFT). Dr. Patricia Cowings of 1- 1 NASA-Ames Research Center has also successfully used AFT in her studies (7...analysis can be completed. Summary of Current Knowledge Researchers have approached the problem of motion sick- ness in several ways. One approach is to...that the technique is not "black magic" (17). Despite apparent successes by Dr. Levy and others, notably Dr. Patricia Cowings of the NASA-Ames Research

GEEC All the Way Down

DTIC Science & Technology

2015-01-13

applying formal methods to systems software, e.g., IronClad [16] and seL4 [19], promise that this vision is not a fool’s er- rand after all. In this...kernel seL4 [19] is fully verified for functional correct- ness and it runs with other deprivileged services. How- ever, the verification process used...portion, which is non-trivial for theorem proving-based approaches. In our COSS example, adding the trusted network logging extensions to seL4 will

A Comparative Evaluation of the Effects of the Implementation of the Production Oriented Maintenance Organization (POMO) on Aircraft Maintenance

DTIC Science & Technology

1978-09-01

Division AREA & WORK UNIT NUMBERS School of Systems and Logistics’ Air Force Institute of Technology,WPAFB,OH II. CONTROLLING OFFICE NAME AND ADDRESS 12 ...STRUCTURE) ............. ................ 9) 12 . SUMMARY OF ALL ANALYSIS RESUILT,"S ........ ........ 94 vii i LIST OF FIGURES Figure Page 1. Deputy...ness Rate (Variable 4) .... ............ ... 81 12 . Graph of Data Values for Abort Rate (Variable 5 e) . ..................... 82 13. Graph of Data

Non-equilibrium steady-state distributions of colloids in a tilted periodic potential

NASA Astrophysics Data System (ADS)

Ma, Xiaoguang; Lai, Pik-Yin; Ackerson, Bruce; Tong, Penger

A two-layer colloidal system is constructed to study the effects of the external force F on the non-equilibrium steady-state (NESS) dynamics of the diffusing particles over a tilted periodic potential, in which detailed balance is broken due to the presence of a steady particle flux. The periodic potential is provided by the bottom layer colloidal spheres forming a fixed crystalline pattern on a glass substrate. The corrugated surface of the bottom colloidal crystal provides a gravitational potential field for the top layer diffusing particles. By tilting the sample with respect to gravity, a tangential component F is applied to the diffusing particles. The measured NESS probability density function Pss (x , y) of the particles is found to deviate from the equilibrium distribution depending on the driving or distance from equilibrium. The experimental results are compared with the exact solution of the 1D Smoluchowski equation and the numerical results of the 2D Smoluchowski equation. Moreover, from the obtained exact 1D solution, we develop an analytical method to accurately extract the 1D potential U0 (x) from the measured Pss (x) . Work supported in part by the Research Grants Council of Hong Kong SAR.

Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells.

PubMed

Son, M-Y; Sim, H; Son, Y S; Jung, K B; Lee, M-O; Oh, J-H; Chung, S-K; Jung, C-R; Kim, J

2017-12-01

The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is the most common genetic cause of Parkinson's disease (PD). There is compelling evidence that PD is not only a brain disease but also a gastrointestinal disorder; nonetheless, its pathogenesis remains unclear. We aimed to develop human neural and intestinal tissue models of PD patients harbouring an LRRK2 mutation to understand the link between LRRK2 and PD pathology by investigating the gene expression signature. We generated PD patient-specific induced pluripotent stem cells (iPSCs) carrying an LRRK2 G2019S mutation (LK2GS) and then differentiated into three-dimensional (3D) human neuroectodermal spheres (hNESs) and human intestinal organoids (hIOs). To unravel the gene and signalling networks associated with LK2GS, we analysed differentially expressed genes in the microarray data by functional clustering, gene ontology (GO) and pathway analyses. The expression profiles of LK2GS were distinct from those of wild-type controls in hNESs and hIOs. The most represented GO biological process in hNESs and hIOs was synaptic transmission, specifically synaptic vesicle trafficking, some defects of which are known to be related to PD. The results were further validated in four independent PD-specific hNESs and hIOs by microarray and qRT-PCR analysis. We provide the first evidence that LK2GS also causes significant changes in gene expression in the intestinal cells. These hNES and hIO models from the same genetic background of PD patients could be invaluable resources for understanding PD pathophysiology and for advancing the complexity of in vitro models with 3D expandable organoids. © 2017 British Neuropathological Society.

The Defender’s Dilemma: Charting a Course Toward Cybersecurity

DTIC Science & Technology

2015-01-01

Security concerns on the Internet began with the introduction of the Morris worm in November 1988,1 and since that time we have wit- nessed the...Patch Tuesday .” This is when security patches and updates are released for users to implement. As such, “Exploit Wednesday” usually fol- lows “Patch... Tuesday ,” as users are not generally quick to immediately patch their systems. 23 E.g., Oracle or Microsoft patch on a fixed schedule, but will make

Ideas in Arms: The Relationship of Kinetic and Ideological Means in America’s Global War on Terror

DTIC Science & Technology

2008-04-01

ness should become apparent. The Nature of War Clausewitz contends that the collective decision to wield the instrument of war as an expression of...an abstract war, describing armed conflict as it would exist without restraint. At its core, Clausewitz contends , “war is an act of force, and...indicative of their probable importance to the system, to the enemy that you’re trying to change.”26 Thus, in seeking enemy defeat, War- den contends

Developing the Mid-Level Civilian Logistician: An Empirical Study of United States Air Force GS-12 to GM-13 Professional Development.

DTIC Science & Technology

1989-09-01

airimn : PME NUMBER OF APPLICABLE RESPONSES PROGRAMS S S~ 1quadron Off icer-S SchoolI. Ai~rCcr 1 .n College, Air War College: self-direct-d Table 11...8217 betweenr- thie number of e:;ist ~p ~msancre:.t7 lcg~stiian weak-nesses (r -. 8545 ) Inditc. r: lo:w pcoitlive correlation e:xists b_-etween thenubr...equivalent) c. Industrial College of the Armed Forces d. Defense Systems Management Course e. Air War College (or equivalent) f. Other (please specify) g

Holographic Floquet states I: a strongly coupled Weyl semimetal

NASA Astrophysics Data System (ADS)

Hashimoto, Koji; Kinoshita, Shunichiro; Murata, Keiju; Oka, Takashi

2017-05-01

Floquet states can be realized in quantum systems driven by continuous time-periodic perturbations. It is known that a state known as the Floquet Weyl semimetal can be realized when free Dirac fermions are placed in a rotating electric field. What will happen if strong interaction is introduced to this system? Will the interaction wash out the characteristic features of Weyl semimetals such as the Hall response? Is there a steady state and what is its thermodynamic behavior? We answer these questions using AdS/CFT correspondence in the N = 2 supersymmetric massless QCD in a rotating electric field in the large N c limit realizing the first example of a "holographic Floquet state". In this limit, gluons not only mediate interaction, but also act as an energy reservoir and stabilize the nonequilibrium steady state (NESS). We obtain the electric current induced by a rotating electric field: in the high frequency region, the Ohm's law is satisfied, while we recover the DC nonlinear conductivity at low frequency, which was obtained holographically in a previous work. The thermodynamic properties of the NESS, e.g., fluctuation-dissipation relation, is characterized by the effective Hawking temperature that is defined from the effective horizon giving a holographic meaning to the "periodic thermodynamic" concept. In addition to the strong (pump) rotating electric field, we apply an additional weak (probe) electric field in the spirit of the pump-probe experiments done in condensed matter experiments. Weak DC and AC probe analysis in the background rotating electric field shows Hall currents as a linear response, therefore the Hall response of Floquet Weyl semimetals survives at the strong coupling limit. We also find frequency mixed response currents, i.e., a heterodyning effect, characteristic to periodically driven Floquet systems.

No safe place: parental alcoholism and adolescent suicide.

PubMed

Meyer, D C; Phillips, W M

1990-10-01

A child growing up in an alcoholic home develops either little self-consolidation (I-ness) and efficacy (I can) or a distorted self (I am insignificant). This results in a desperate search for a soothing-object (We-ness). The sadomasochistic behaviors, which a youth witnesses and is subjected to, become internalized as survival skills, but ultimately fail. These factors set the stage for a destructive modus operandi. When there is peer group attachment pressure, this teen does not find security when questioning, "Who am I?" because there is no "I" and no "We". Instead, this adolescent experiences fear, anxiety, and range, and wonders, "What's going to happen to me?" This propels the youth into frantic behaviors that are meant to confirm a sense of "We-ness" and competence. The result, however, is greater frustration and a mirroring of the opposite. Also, since there is a diminutive capacity for trust and an exiguous chance to reach out or respond to significant others, external soothingness becomes unobtainable. When the adolescent is confronted with aloneness, helplessness, and hopelessness, desperation results and a search for a safe place ensues. Suicide holds such an illusion. It is the embodiment of sadomasochism and permits the cognition "I am capable." A case study illustrates the problems.

Systemic-constructivist couple therapy (SCCT): Description of approach, theoretical advances, and published longitudinal evidence.

PubMed

Reid, David W; Doell, Faye K; Dalton, E Jane; Ahmad, Saunia

2008-12-01

The systemic-constructivist approach to studying and benefiting couples was derived from qualitative and quantitative research on distressed couples over the past 10 years. Systemic-constructivist couple therapy (SCCT) is the clinical intervention that accompanies the approach. SCCT guides the therapist to work with both the intrapersonal and the interpersonal aspects of marriage while also integrating the social-environmental context of the couple. The theory that underlies SCCT is explained, including concepts such as we-ness and interpersonal processing. The primary components of the therapy are described. Findings described previously in an inaugural monograph containing extensive research demonstrating the long-term utility of SCCT are reviewed. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

Spikes alone do not behavior make: Why neuroscience needs biomechanics

PubMed Central

Tytell, E.D.; Holmes, P.; Cohen, A.H.

2011-01-01

Neural circuits do not function in isolation; they interact with the physical world, accepting sensory inputs and producing outputs via muscles. Since both these pathways are constrained by physics, the activity of neural circuits can only be understood by considering biomechanics of muscles, bodies, and the exterior world. We discuss how animal bodies have natural stable motions that require relatively little activation or control from the nervous system. The nervous system can substantially alter these motions, by subtly changing mechanical properties such as leg sti ness. Mechanics can also provide robustness to perturbations without sensory reflexes. By considering a complete neuromechanical system, neuroscientists and biomechanicians together can provide a more integrated view of neural circuitry and behavior. PMID:21683575

Empowering open systems through cross-platform interoperability

NASA Astrophysics Data System (ADS)

Lyke, James C.

2014-06-01

Most of the motivations for open systems lie in the expectation of interoperability, sometimes referred to as "plug-and-play". Nothing in the notion of "open-ness", however, guarantees this outcome, which makes the increased interest in open architecture more perplexing. In this paper, we explore certain themes of open architecture. We introduce the concept of "windows of interoperability", which can be used to align disparate portions of architecture. Such "windows of interoperability", which concentrate on a reduced set of protocol and interface features, might achieve many of the broader purposes assigned as benefits in open architecture. Since it is possible to engineer proprietary systems that interoperate effectively, this nuanced definition of interoperability may in fact be a more important concept to understand and nurture for effective systems engineering and maintenance.

Program Manager: Journal of the Defense Systems Management College, Volume 22, Number 6, November - December 1993

DTIC Science & Technology

1993-12-01

in the busi - ness...."- Congressional intervention in rebuilding the Navy was undenvay and would increase in magnitude and frequency. Construction...and tie OC- pr11OVcd cha racicriSt ics iii to corn pcItcd ti"c11mC. huLt tIic cra, of ilntcHrnat ioiia cUII pai thicrcafter shiarcd ii uclIi of tile...and heavy equipment. ferred for years: the use of liquid fuel as a part-time coal substitute. Much of the Navy’s business was controlled by brokers

Cavity Opto-Mechanics using an Optically Levitated Nanosphere

DTIC Science & Technology

2010-01-19

curve ) as a function of cavity finesseF≡ πc∕κL, assuming negligible gas collisions and subject to the constraints 2ζ, Ωm∕κ, Ωm∕ωm < 1∕2 and optimized...over detuning δ2. For low cavity fi- nesse the cooling is nearly limited by sideband resolution ( ~nf ;min, red curve ), and the ground-state regime hnf i...input light for each of the two systems (denoted A, B), given by X ðjÞþ;in ¼ Figure 2. A) Mean phonon number hnf i (black curve ) versus cavity

Mixed Methods Research: The "Thing-ness" Problem.

PubMed

Hesse-Biber, Sharlene

2015-06-01

Contemporary mixed methods research (MMR) veers away from a "loosely bounded" to a "bounded" concept that has important negative implications for how qualitatively driven mixed methods approaches are positioned in the field of mixed methods and overall innovation in the praxis of MMR. I deploy the concept of reification defined as taking an object/abstraction and treating it as if it were real such that it takes on the quality of "thing-ness," having a concrete independent existence. I argue that the contemporary reification of mixed methods as a "thing" is fueled by three interrelated factors: (a) the growing formalization of mixed methods as design, (b) the unexamined belief in the "synergy" of mixed methods and, (c) the deployment of a "practical pragmatism" as the "philosophical partner" for mixed methods inquiry. © The Author(s) 2015.

Knowledge bases built on web languages from the point of view of predicate logics

NASA Astrophysics Data System (ADS)

Vajgl, Marek; Lukasová, Alena; Žáček, Martin

2017-06-01

The article undergoes evaluation of formal systems created on the base of web (ontology/concept) languages by simplifying the usual approach of knowledge representation within the FOPL, but sharing its expressiveness, semantic correct-ness, completeness and decidability. Evaluation of two of them - that one based on description logic and that one built on RDF model principles - identifies some of the lacks of those formal systems and presents, if possible, corrections of them. Possibilities to build an inference system capable to obtain new further knowledge over given knowledge bases including those describing domains by giant linked domain databases has been taken into account. Moreover, the directions towards simplifying FOPL language discussed here has been evaluated from the point of view of a possibility to become a web language for fulfilling an idea of semantic web.

Erik Ness | NREL

Science.gov Websites

. Erik has also had an interest in promoting tribal energy development since the 1990s, when he worked Industry and Trade, London School of Economics, England U.S. Department of the Interior, Project Management

WMATA (Washington Metropolitan Area Transit Authority) 1985 annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1985-12-31

Ridership continues to grow with 210.9 million trips taken during calendar year 1985. The Red Line from Van Ness-UDC to Shady Grove opened in late 1984 and helped stimulate the growth. Meanwhile, construction gets underway on the Green Line with groundbreakings at Anacostia and West Hyattsville stations. The Board approves the Green Line alignment between Columbia Heights and Fort Totten, ending years of discussion and study. Report's feature articles deal with preventive maintenance, the need to finish building the 103-mile system, safety, Metro-related development and the five-year capital improvement plan. The report contains eight pages of financial statements.

Health tourism: definition focused on the Swiss market and conceptualisation of health(i)ness.

PubMed

Hofer, Susanne; Honegger, Franziska; Hubeli, Jonas

2012-01-01

This paper's purpose is to give an overview of current research regarding the concept of "health tourism" with a focus on Switzerland, and to determine whether a consensus on this concept and its embedding in existing/future markets can be found. The paper is an explorative study combining literature review, questionnaires and qualitative interviews. Grounded theory was employed. A service from the field of health care must have been provided prior to health tourism, allowing it to be classified under the health care system. Thus, health tourism is classified under the market for the sick and not under tourism which targets the healthy. Furthermore a new market for the healthy is emerging, which needs to be defined. As an example health(i)ness could help to clarify the terminology, to be seen as a gatekeeper of health and as a cultural paradigm change from cure to prevention. Further research is needed, regarding the positioning and development of health tourism and its synergies, as the cost pressures in health care increase and will continue to have a sustainable impact on health tourism. The paper provides better knowledge of the term health tourism, its general classification, and particular reference to Switzerland, and information about upcoming changes in health care. The findings add to the knowledge of how health tourism is embedded into health care and tourism, and show potential within the market for the healthy. It provides information to members of the tourism and health care market.

JPRS Report, China.

DTIC Science & Technology

1991-02-28

in order to improve market competitive- west, and fine conditions for developing tourism. Uti - ness and foreign-exchange-earning capabilities. lizing...34 permitted to become lawyers, accountants, medical doc- or "naive wishful thinking." Moreover, it seems that tors, veterinarians, pharmacists

Performance of buried pipe installation : technical summary.

DOT National Transportation Integrated Search

2010-05-01

The goal of this research project was to determine the effects of geometric and mechanical parameters characterizing the soil-structure interaction developed in a buried pipe installation. Parameters such as pipe ring stiff ness, bedding thickness, t...

GNSS Wave Glider: First results from Loch Ness and demonstration of its suitability for determining the marine geoid

NASA Astrophysics Data System (ADS)

Penna, N. T.; Morales Maqueda, M.; Williams, S. D.; Foden, P.; Martin, I.; Pugh, J.

2013-12-01

We report on a first deployment of a GNSS Wave Glider designed for precise, unmanned, autonomous, mobile self-propelled sea level and sea state measurement in the open ocean. The Wave Glider, equipped with a dual frequency GPS+GLONASS receiver, was deployed in Loch Ness, Scotland, autonomously travelling 32 km in a north-easterly direction along the length of the loch in 26 hours, propelled by energy generated from waves of typical amplitude only 100-150 mm and frequency on the order 0.5-1 Hz. The Wave Glider GNSS data were analysed using a post-processed kinematic GPS+GLONASS precise point positioning (PPP) approach, which were quality controlled using double difference GPS kinematic processing with respect to onshore reference stations at either end of the loch. The PPP heights of the loch's surface revealed a clear geoid gradient of about 30 mm/km (i.e. just under 1 m over the whole length of the loch), very similar to both the EGM2008 and OSGM02 geoid models, demonstrating the potential use of a GNSS Wave Glider for marine geoid determination. After applying a low pass filter, the GNSS heights showed local deviations from both EGM2008 and OSGM02, potentially caused by omission errors or a lack of gravity data over Loch Ness. In addition to dual frequency GNSS data, the Wave Glider also recorded inclinometer data, bathymetry, and surface currents, which, in combination with tide gauge and wind data, were used to further control and interpret the GNSS time series.

Reproducing whiteness and enacting kin in the Nordic context of transnational egg donation: Matching donors with cross-border traveller recipients in Finland.

PubMed

Homanen, Riikka

2018-04-01

The multimillion-euro fertility industry increasingly tailors its treatments to infertile people who are willing to travel across national borders for treatments inaccessible at home, especially reproductive tissue donor treatments. Finland is the Nordic destination for access to donor eggs, particularly for Swedes and Norwegians hoping for a donor match that will achieve a child of phenotypically plausible biological descent. Finns are seen as Nordic kin, and the inheritability of "Nordicness" is reinforced at clinics. Drawing on ethnographic material from three fertility clinics in Finland during 2015-2017, this article discusses how Nordic relatedness and whiteness are enacted in the practices of matching of donors with recipient parents. The analysis shows a selective and exclusionary rationale to matching built around whiteness: matches between donors with dark skin tone and recipients with fair skin tone are rejected, but a match of a donor with fair skin and recipients with dark skin may be made. Within the context of transnational egg donation, the whiteness or Nordicness of Finns is not questioned as it has been in other historical circumstances. Even the establishment of a state donor register offers a guarantee of kin-ness, especially non-Russian kin-ness. It is concluded that the logics of matching protect the "purity" of whiteness but not browness or blackness, enacting Nordic(kin)ness in ways that are part of broader intra-European histories of racism and post-socialist Othering. Copyright © 2018 Elsevier Ltd. All rights reserved.

Young Children's Mathematics References during Free Play in Family Childcare Settings

ERIC Educational Resources Information Center

Hendershot, Shawnee M.; Berghout Austin, Ann M.; Blevins-Knabe, Belinda; Ota, Carrie

2016-01-01

Very little is known about children's discussion of mathematics topics during unstructured play. Ginsburg, Lin, Ness, and Seo [2003. Young American and Chinese children's everyday mathematical activity. Mathematical Thinking and Learning, 5(4), 235-258. Retrieved from…

Youth Attitude Tracking Study: Spring 1980.

DTIC Science & Technology

1980-08-01

integral part of service adver- tising, especially for the Marine Corps. Slogans always have been an effective means of generating and sustaining brand ... awareness . Tracking the recognition of service advertising slogans, therefore, is another means of assessing the effective- ness of service advertising

Calendar of Selected Aeronautical and Space Meetings January 1988 (Calendrier des Manifestations Aeronautiques et Spatiales (Selection) Janvier 1988).

DTIC Science & Technology

1987-12-01

margin indicates a ness cntr\\, xx in the left-hand margin indicates a ncw entr\\ subjcti to confirmation. A Subject Index in the form of keywords is...12-1)4. 1_-1)7 Electronic Measurements 0)2-25). 1)12-7. 02-89, 0)2-93. 11412. 11-i)8 Electronic SYtems 012-), 1)2-19. 12-1. (12-14. 02-10. 0)2-2(, 02...4-13. (4-14, 04-17. 04-18. 04-19. 04-20. ((6-22. 07-49. (9-23. 09-32. 12-07 Fluid Systems 04-01, 04-2(0. 06-12. 12-19 Forming 07-44. 07-51 Fracture

"Abuelita" Epistemologies: Counteracting Subtractive Schools in American Education

ERIC Educational Resources Information Center

Gonzales, Sandra M.

2015-01-01

This autoethnographic inquiry examines the intersection of elder epistemology and subtractive education, exploring how one "abuelita" countered her granddaughter's divestment of Mexican-ness. I demonstrate how the grandmother used "abuelita" epistemologies to navigate this tension and resist the assimilative pressures felt…

Toward A National Biodefense Strategy: Challenges and Opportunities

DTIC Science & Technology

2003-04-01

Clostridium perfringens • Glanders ( Burkholderia mallei ) •Melioidosis ( Burkholderia pseudomallei) •Psittacosis (Chlamydia psittaci) •Q fever (Coxiella...its interests, orthose of friends and allies with biological weapons (BW). The last century wit- nessed the purported use of glanders by the Germans

Concurrent enterprise: a conceptual framework for enterprise supply-chain network activities

NASA Astrophysics Data System (ADS)

Addo-Tenkorang, Richard; Helo, Petri T.; Kantola, Jussi

2017-04-01

Supply-chain management (SCM) in manufacturing industries has evolved significantly over the years. Recently, a lot more relevant research has picked up on the development of integrated solutions. Thus, seeking a collaborative optimisation of geographical, just-in-time (JIT), quality (customer demand/satisfaction) and return-on-investment (profits), aspects of organisational management and planning through 'best practice' business-process management - concepts and application; employing system tools such as certain applications/aspects of enterprise resource planning (ERP) - SCM systems information technology (IT) enablers to enhance enterprise integrated product development/concurrent engineering principles. This article assumed three main organisation theory applications in positioning its assumptions. Thus, proposing a feasible industry-specific framework not currently included within the SCOR model's level four (4) implementation level, as well as other existing SCM integration reference models such as in the MIT process handbook's - Process Interchange Format (PIF), the TOVE project, etc. which could also be replicated in other SCs. However, the wider focus of this paper's contribution will be concentrated on a complimentary proposed framework to the SCC's SCOR reference model. Quantitative empirical closed-ended questionnaires in addition to the main data collected from a qualitative empirical real-life industrial-based pilot case study were used: To propose a conceptual concurrent enterprise framework for SCM network activities. This research adopts a design structure matrix simulation approach analysis to propose an optimal enterprise SCM-networked value-adding, customised master data-management platform/portal for efficient SCM network information exchange and an effective supply-chain (SC) network systems-design teams' structure. Furthermore, social network theory analysis will be employed in a triangulation approach with statistical correlation analysis to assess the scale/level of frequency, importance, level of collaborative-ness, mutual trust as well as roles and responsibility among the enterprise SCM network for systems product development (PD) design teams' technical communication network as well as extensive literature reviews.

Preliminary evaluation of a commercially available videogame system as an adjunct therapeutic intervention for improving balance among children and adolescents with lower limb amputations.

PubMed

Andrysek, Jan; Klejman, Susan; Steinnagel, Bryan; Torres-Moreno, Ricardo; Zabjek, Karl F; Salbach, Nancy M; Moody, Kim

2012-02-01

To examine the safety, feasibility, and balance performance effects of a 4-week home-based balance therapy program using a commercially available videogame system. A pilot study involving a preintervention and postintervention design was conducted with measurements taken at baseline, immediately postintervention (week 5), and at follow-up (week 13) for retention. University hospital outpatient clinic and participants' places of residence. Children and adolescents with unilateral lower limb amputation (n=6; 3 transfemoral [TF] and 3 Van Ness) and age-matched, typically developing individuals (n=10) for baseline comparison. Two videogames involving weight shifting in standing were each played at home for 20 min/d, 4d/wk for a period of 4 weeks. A physical therapist provided initial instruction and monitoring. Postural control characteristics using center of pressure (COP) displacements during quiet standing; functional balance using the Community Balance and Mobility Scale (CB&M); and compliance, safety, and feasibility using custom questionnaires. Average playing times for the first 3 weeks ranged from 16.0 to 21.1 minutes for the 2 games. At baseline, the children and adolescents with TF amputation had substantially greater COP displacements than the Van Ness group and typically developing children and adolescents. Immediately postintervention, the COP displacements decreased in the TF amputees, resulting in values that were closer to those of the typically developing children. The average increase in CB&M score from baseline to follow-up was 6 points across participants. In-home, videogame-based balance training therapies can achieve excellent compliance in children and adolescents with lower limb amputation. With proper instructions and monitoring, the therapeutic intervention can be safely administered. Some improvements in postural control characteristics were seen in children and adolescents with balance deficits immediately postintervention, but long-term retention remains unclear. Copyright © 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Being me and being us in a family living close to death at home.

PubMed

Carlander, Ida; Ternestedt, Britt-Marie; Sahlberg-Blom, Eva; Hellström, Ingrid; Sandberg, Jonas

2011-05-01

We used interpretive description to describe how everyday life close to death was experienced and dealt with in families with one member who had a life-threatening illness. We performed 28 individual, couple, and group interviews with five families. We found two patterns, namely, "being me in a family living close to death" and "being us in a family living close to death." "Being me" meant that every individual in the family had to deal with the impending death, regardless of whether or not he or she was the person with the life-threatening illness. This was linked to ways of promoting the individual's self-image, or "me-ness." This pattern was present at the same time as the pattern of "being us," or in other words, being a family, and dealing with impending death and a new "we-ness" as a group. "Striving for the optimal way of living close to death" was the core theme.

Measuring sea surface height with a GNSS-Wave Glider

NASA Astrophysics Data System (ADS)

Morales Maqueda, Miguel Angel; Penna, Nigel T.; Foden, Peter R.; Martin, Ian; Cipollini, Paolo; Williams, Simon D.; Pugh, Jeff P.

2017-04-01

A GNSS-Wave Glider is a novel technique to measure sea surface height autonomously using the Global Navigation Satellite System (GNSS). It consists of an unmanned surface vehicle manufactured by Liquid Robotics, a Wave Glider, and a geodetic-grade GNSS antenna-receiver system, with the antenna installed on a mast on the vehicle's deck. The Wave Glider uses the differential wave motion through the water column for propulsion, thus guaranteeing an, in principle, indefinite autonomy. Solar energy is collected to power all on-board instrumentation, including the GNSS system. The GNSS-Wave Glider was first tested in Loch Ness in 2013, demonstrating that the technology is capable of mapping geoid heights within the loch with an accuracy of a few centimetres. The trial in Loch Ness did not conclusively confirm the reliability of the technique because, during the tests, the state of the water surface was much more benign than would normally be expect in the open ocean. We now report on a first deployment of a GNSS-Wave Glider in the North Sea. The deployment took place in August 2016 and lasted thirteen days, during which the vehicle covered a distance of about 350 nautical miles in the north western North Sea off Great Britain. During the experiment, the GNSS-Wave Glider experienced sea states between 1 (0-0.1 m wave heights) and 5 (2.5-4 m wave heights). The GNSS-Wave Glider data, recorded at 5 Hz frequency, were analysed using a post-processed kinematic GPS-GLONASS precise point positioning (PPP) approach, which were quality controlled using double difference GPS kinematic processing with respect to onshore reference stations. Filtered with a 900 s moving-average window, the PPP heights reveal geoid patterns in the survey area that are very similar to the EGM2008 geoid model, thus demonstrating the potential use of a GNSS-Wave Glider for marine geoid determination. The residual of subtracting the modelled or measured marine geoid from the PPP signal combines information about dynamic topography and sea state. GNSS-Wave Glider data will next be validated against concurrent and co-located satellite altimetry data from the Jason-1, Jason-2, CryoSat-2 and AltiKa missions.

Framework Thinking, Subject Thinking and "Taiwan-"ness"" in Environmental Education

ERIC Educational Resources Information Center

Yueh, Mei-Chun Michelle; Barker, Miles

2011-01-01

In the 1998 Taiwanese national curriculum revision, environmental education was one of six new "Important Issues". To some early observers, the generic "framework" sections of this 1998 curriculum (Aims, Goals, Core Competences) resonated well with the integrative and transdisciplinary nature of environmental education. This…

Enhancing the Relationship Adjustment of South Asian Canadian Couples Using a Systemic-Constructivist Approach to Couple Therapy.

PubMed

Ahmad, Saunia; Reid, David W

2016-10-01

The effectiveness of systemic-constructivist couple therapy (SCCT) in improving the relationship adjustment of South Asian Canadian couples in ways that attend to their culture was evaluated. The SCCT interventions engage partners in reflexive processing of both their own and their partner's ways of construing, and the reciprocity between these two. A core change mechanism of SCCT, couple identity ("we-ness"), that connotes the ability for thinking and experiencing relationally, was coded from verbatim transcripts of partners' within-session dialogue. As predicted, South Asian partners' relationship adjustment improved significantly from the first to final session of SCCT, and concurrent increases in each partner's couple identity mediated such improvements. The implications for considering culture and couple identity in couple therapy are discussed. Video Abstract is found in the online version of the article. © 2016 American Association for Marriage and Family Therapy.

A New Stochastic Equivalent Linearization Implementation for Prediction of Geometrically Nonlinear Vibrations

NASA Technical Reports Server (NTRS)

Muravyov, Alexander A.; Turner, Travis L.; Robinson, Jay H.; Rizzi, Stephen A.

1999-01-01

In this paper, the problem of random vibration of geometrically nonlinear MDOF structures is considered. The solutions obtained by application of two different versions of a stochastic linearization method are compared with exact (F-P-K) solutions. The formulation of a relatively new version of the stochastic linearization method (energy-based version) is generalized to the MDOF system case. Also, a new method for determination of nonlinear sti ness coefficients for MDOF structures is demonstrated. This method in combination with the equivalent linearization technique is implemented in a new computer program. Results in terms of root-mean-square (RMS) displacements obtained by using the new program and an existing in-house code are compared for two examples of beam-like structures.

Strategic plans open for comment

NASA Astrophysics Data System (ADS)

Under the Government Performance and Results Act (the Results Act), agencies of the U.S. government are required to submit a 5-year strategic plan to the U.S. Congress by September 30, 1997 explaining how, when, and why they are spending tax dollars.Enacted in 1993, the Results Act is in tended to "improve efficiency and effective ness of Federal programs by establishing a system to set goals for program performance and to measure results." Thus according to the U.S. House of Representatives Committee on Science, the aim is for agencies to measure their performances by the results of their task and services, not by the number of tasks and services performed. Toward that goal, the Act requires that federal entities complete the following 3-step process:

Climatology of the Aerosol Optical Depth by Components from the Multi-Angle Imaging Spectroradiometer (MISR) and Chemistry Transport Models

NASA Technical Reports Server (NTRS)

Lee, Huikyo; Kalashnikova, Olga V.; Suzuki, Kentaroh; Braverman, Amy; Garay, Michael J.; Kahn, Ralph A.

2016-01-01

The Multi-angle Imaging Spectroradiometer (MISR) Joint Aerosol (JOINT_AS) Level 3 product has provided a global, descriptive summary of MISR Level 2 aerosol optical depth (AOD) and aerosol type information for each month over 16+ years since March 2000. Using Version 1 of JOINT_AS, which is based on the operational (Version 22) MISR Level 2 aerosol product, this study analyzes, for the first time, characteristics of observed and simulated distributions of AOD for three broad classes of aerosols: spherical nonabsorbing, spherical absorbing, and nonspherical - near or downwind of their major source regions. The statistical moments (means, standard deviations, and skew-nesses) and distributions of AOD by components derived from the JOINT_AS are compared with results from two chemistry transport models (CTMs), the Goddard Chemistry Aerosol Radiation and Transport (GOCART) and SPectral RadIatioN-TrAnSport (SPRINTARS). Overall, the AOD distributions retrieved from MISR and modeled by GOCART and SPRINTARS agree with each other in a qualitative sense. Marginal distributions of AOD for each aerosol type in both MISR and models show considerable high positive skewness, which indicates the importance of including extreme AOD events when comparing satellite retrievals with models. The MISR JOINT_AS product will greatly facilitate comparisons between satellite observations and model simulations of aerosols by type.

Old wine in new bottles: decanting systemic family process research in the era of evidence-based practice.

PubMed

Rohrbaugh, Michael J

2014-09-01

Social cybernetic (systemic) ideas from the early Family Process era, though emanating from qualitative clinical observation, have underappreciated heuristic potential for guiding quantitative empirical research on problem maintenance and change. The old conceptual wines we have attempted to repackage in new, science-friendly bottles include ironic processes (when "solutions" maintain problems), symptom-system fit (when problems stabilize relationships), and communal coping (when we-ness helps people change). Both self-report and observational quantitative methods have been useful in tracking these phenomena, and together the three constructs inform a team-based family consultation approach to working with difficult health and behavior problems. In addition, a large-scale, quantitatively focused effectiveness trial of family therapy for adolescent drug abuse highlights the importance of treatment fidelity and qualitative approaches to examining it. In this sense, echoing the history of family therapy research, our experience with juxtaposing quantitative and qualitative methods has gone full circle-from qualitative to quantitative observation and back again. © 2014 FPI, Inc.

Old Wine in New Bottles: Decanting Systemic Family Process Research in the Era of Evidence-Based Practice†

PubMed Central

Rohrbaugh, Michael J.

2015-01-01

Social cybernetic (systemic) ideas from the early Family Process era, though emanating from qualitative clinical observation, have underappreciated heuristic potential for guiding quantitative empirical research on problem maintenance and change. The old conceptual wines we have attempted to repackage in new, science-friendly bottles include ironic processes (when “solutions” maintain problems), symptom-system fit (when problems stabilize relationships), and communal coping (when we-ness helps people change). Both self-report and observational quantitative methods have been useful in tracking these phenomena, and together the three constructs inform a team-based family consultation (FAMCON) approach to working with difficult health and behavior problems. In addition, a large-scale, quantitatively focused effectiveness trial of family therapy for adolescent drug abuse highlights the importance of treatment fidelity and qualitative approaches to examining it. In this sense, echoing the history of family therapy research, our experience with juxtaposing quantitative and qualitative methods has gone full circle – from qualitative to quantitative observation and back again. PMID:24905101

Army Sustainment. Volume 42, Issue 5, September-October 2010

DTIC Science & Technology

2010-10-01

pollution ...creating power plants. Busi- ness prac tices that lead to increased vehicle traffic use more gasoline and create more exhaust pollution . Trash must be...replacing bottled water, which has been a prime target for environmentalists. At least one company offers a compostable plastic water bottle that

1. Photocopy of engraving by D.C. Baxter (taken from page ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of engraving by D.C. Baxter (taken from page 24 of the Philadelphia, Wilmington & Balltimore Railroad guide, Fitzgibbon and Van Ness, Philadelphia, 1856) GENERAL VIEW OF STATION (C.1856) - Philadelphia, Wilmington & Baltimore Railroad, President Street Station, President & Fleet Streets, Baltimore, Independent City, MD

Engaging Children's Spontaneous Questions about Social Diversity

ERIC Educational Resources Information Center

Ryken, Amy E.

2015-01-01

In this article the author shares conversations she has had with elementary students inquiring about her gender identity to make visible the daily-ness of conversations about sameness and difference and to surface her own struggles with, and pedagogical deliberations about, these conversations. The conversations are conceptualized as both the unit…

Students' Self-Perceptions of Apologies to Instructors

ERIC Educational Resources Information Center

Cheng, Dongmei

2017-01-01

Adopting retrospective verbal report, or RVR as the instrument, this study reports an analysis of the perceptions of native-English-speaking (NES) and non-native-English-speaking (NNES) students, who apologised to their instructors in coursework-related situations. Sixty NESs from different levels and disciplinary areas and 63 NNESs (Arabic and…

Internet Investigations: Mixing Talent with Teachers and Telecommunications.

ERIC Educational Resources Information Center

Brown, Mark E.; Riley, Tracy L.

1998-01-01

Describes how teams of grade 4-9 gifted students investigated unsolved mysteries like Bigfoot, aliens and UFOs, the Loch Ness Monster, and Stonehenge to develop Internet and research skills. Highlights student observations on difficulties encountered using the Internet for research, notes student evaluation of the workshop, and provides addresses…

The Ethics of Archival Research

ERIC Educational Resources Information Center

McKee, Heidi A.; Porter, James E.

2012-01-01

What are the key ethical issues involved in conducting archival research? Based on examination of cases and interviews with leading archival researchers in composition, this article discusses several ethical questions and offers a heuristic to guide ethical decision making. Key to this process is recognizing the person-ness of archival materials.…

Missing Things and Methodological Swerves: Unsettling the It-Ness of VET

ERIC Educational Resources Information Center

Shore, Sue; Butler, Elaine

2012-01-01

This paper argues for approaches to research methodologies that interrupt the machinic metaphors and relationships for living circulating in so much VET research. Using the schematic of "cyborg as a figuration" and Wilson's (2009) four epistemological interventions (witnessing, situating, diffracting, acquiring) the authors practice a form of…

"We're All Appalachian."

ERIC Educational Resources Information Center

Banker, Mark

2002-01-01

A teacher at a Knoxville college preparatory school challenges his students to analyze stereotypes about Appalachia and recognize that acceptance of their own Appalachian-ness is vital to their personal well-being and that of the region. Comparisons of Appalachians with Hispanics in northern New Mexico reveal common issues of land use, cultural…

School-Aged Children's Phonological Production of Derived English Words

ERIC Educational Resources Information Center

Jarmulowicz, Linda

2006-01-01

Purpose: Little is known about the phonological aspects of derivational processes. Neutral suffixes (e.g., "-ness") that do not change stress and rhythmic or nonneutral suffixes (e.g., "-ity") that alter stem stress were used in a production task that explored developmental changes in phonological accuracy of derived English…

Semiannual Technical Summary, 1 October 1985-31 March 1986

DTIC Science & Technology

1986-05-01

see Braille , 1973; Ruud, 1986) to estimate velocities and crustal thick- ness. The outcome of such an experiment, on the basis of ŗ-component...Phys. Earth Planet. Inter., 15, 13-27. Braille , L.W. (1973): Inversion of crustal seismic refraction and reflection data, J. Geophy. Res., 78, 7738-7744

The Australian-Ness of Curriculum Jigsaws: Where Does Environmental Education Fit?

ERIC Educational Resources Information Center

Gough, Annette

2011-01-01

This paper reviews Australian Government actions related to environmental education, particularly in the past decade, and examines the actions forthcoming from two national action plans (Environment Australia, 2000 and DEWHA, 2009), the implementation strategy for the Decade of ESD (DEWHA, 2006) and developments related to the Australian…

Tracking Hierarchical Processing in Morphological Decomposition with Brain Potentials

ERIC Educational Resources Information Center

Lavric, Aureliu; Elchlepp, Heike; Rastle, Kathleen

2012-01-01

One important debate in psycholinguistics concerns the nature of morphological decomposition processes in visual word recognition (e.g., darkness = {dark} + {-ness}). One theory claims that these processes arise during orthographic analysis and prior to accessing meaning (Rastle & Davis, 2008), and another argues that these processes arise through…

Polymeric and Molecular Materials for Advanced Organic Electronics

DTIC Science & Technology

2014-10-20

x - ray reflectivity, grazing incidence x - ray scattering, cyclic voltam- metry...6). ix These materials are characterized by AFM, conducting AFM, XPS, x - ray reflectivity (XRR), standing wave x - ray reflectivity (SWXRR), x - ray ...radiation hard - ness measurements, and quantum chemical computation of dielectric constants. Remark- ably, for semiconductors as diverse

Arterial Stiffness and Pharmacological Interventions – The TRanscend Arterial stiffNess Substudy (TRANS study)

PubMed Central

Topouchian, Jirar; El Feghali, Ramzi; Pannier, Bruno; Wang, Shuyu; Zhao, Feng; Smetana, Karel; Teo, Koon; Asmar, Roland

2007-01-01

The degree of arterial stiffness is correlated with the risk of cardiovascular diseases and it is a powerful predictor for morbidity and mortality. Studies have shown that arterial stiffness reduction is associated with an improvement in survival. Reduction of arterial stiffness by pharmacological drugs varies according to the drugs and doses used and duration of treatment. This effect on the arteries differs among the various classes of drugs and among individual drugs in the same class. Quantification of the stiffness and other properties of the arterial wall can be used to monitor the responses to therapy in individuals with hypertension and other cardiovascular diseases. These measures can then be used as surrogate markers for the risk of clinical events. Inhibition of the renin-angiotensin system (RAS) is associated with an important decrease in cardiovascular risk. Findings from clinical trials support the hypothesis that the protective effects of RAS inhibition are partly independent from blood pressure reduction and related to several mechanisms including vascular protective effects. The aim of the TRanscend Arterial stiffNess Substudy (TRANS) is to assess the effect of an angiotensin II receptor blocker (ARB), telmisartan, on the arterial stiffness in a subgroup of patients from the Telmisartan Randomized Assessment Study in aCE iNtolerant subjects with cardiovascular Disease (TRANSCEND) trial. The TRANSCEND trial is an international, multicenter, randomized double blind placebo controlled trial of telmisartan that enrolled patients at high risk for cardiovascular events. Some clinical baseline data of the TRANS substudy are reported. When completed, the results of the TRANS substudy will show whether the beneficial effects of treatment with telmisartan on cardiovascular outcome may be related to an improvement in arterial stiffness. PMID:17969367

Bioethical Considerations for Teachers of the Severe and Profoundly Retarded: A Position Paper.

ERIC Educational Resources Information Center

Downie, Don; Snart, Fern

1983-01-01

The paper reviews bioethical positions regarding the "human-ness" of severely handicapped students, notes that the quality of life for many severely handicapped persons is directly threatened by the utilitarian position which questions the personhood of individuals with limited IQ, and asserts that the deontological postition is more aligned with…

Satellite Anomalies: Benefits of a Centralized Anomaly Database and Methods for Securely Sharing Information Among Satellite Operators

DTIC Science & Technology

2014-01-01

unprecedented efficiencies in global busi- ness collaboration through communication, information distribution, and fast electronic monetary transactions...tudes (which peaks in free electron density at 300–400 km but extends to just above 1,000 km). At GEO, surface charging occurs intermit - tently

"Give Us A Privacy": Play and Social Literacy In Young Children

ERIC Educational Resources Information Center

Ghafouri, Farveh; Wien, Carol Anne

2005-01-01

This study argues that children require social literacy to protect and sustain their play: In play, they construct an emotional landscape of "we"-ness to be protected from outsiders. The research consisted of a 4-month-long investigation, which involved audiotaping and videotaping children engaged in self-initiated play in a kindergarten…

Knowledge Synthesis and Application of Crisis-Expectant Lodging/Shelter Guidance.

DTIC Science & Technology

1981-09-30

purpose of this section is: (1) to explore the question of what individuals and groups should be able to do in response to a nuclear disaster ; (2) to...because the awesome- ness of a nuclear disaster elicits a common popular response to any disaster-preparedness message--the denial of the possibility

Ecological Principles Affecting Community Structure and Secondary Production by Zooplankton in Marine and Freshwater Environments

DTIC Science & Technology

1988-01-01

Bialv~al can be common lipid -accumulating copepods or euphau- siids. The latitudinal trend in species rich- ness of freshwaters is the opposite...Cretaceous large- dinosaur com- er. For this reason it is most secure to focus munity (Oldman Formation). Ecology 57: 841- measurement effort on the

Vocabulary Acquisition in an Academic Discipline: ESL Learners and Theology.

ERIC Educational Resources Information Center

Lessard-Clouston, Michael

A study investigated and compared the acquisition of specialized vocabulary among English-as-a-Second Language (ESL) and native English-speaking (NES) graduate students in theology. Research was undertaken in an anglophone city in central Canada. Subjects were 12 students (5 Chinese ESLs, 7 NESs) enrolled in an introductory core theology course. A…

Student Success: How to Make It Happen

ERIC Educational Resources Information Center

Skoglund, Frederic W.; Ness, Judy

2011-01-01

This book is about moving from the conceptual to practical applications that impact the day-to-day teaching and learning processes. Skoglund and Ness give school leaders all the tools that are necessary to change the culture of a school, improve teacher performance, and elevate student achievement. Each component of the process is clearly…

On the Role of Openness in Education: A Historical Reconstruction

ERIC Educational Resources Information Center

Peter, Sandra; Deimann, Markus

2013-01-01

In the context of education, "open(ness)" has become the watermark for a fast growing number of learning materials and associated platforms and practices from a variety of institutions and individuals. Open Educational Resources (OER), Massive Open Online Courses (MOOC), and more recently, initiatives such as Coursera are just some of…

An Australian Story: School Sustainability Education in the Lucky Country

ERIC Educational Resources Information Center

Salter, Zarin; Venville, Grady; Longnecker, Nancy

2011-01-01

This paper documents a case study involving a Perth primary school accompanied on its sustainability journey by Millennium Kids Inc, a local not-for-profit community organisation. Tension between the school's sustainability focus, its prestige as an elite private school and a "lucky country" mentality frames the Australian-ness of this…

Making Ethnic Citizens: The Politics and Practice of Education in Malaysia

ERIC Educational Resources Information Center

Brown, Graham K.

2007-01-01

This paper examines the politics and practice of education in Malaysia within the context of ethnicity and nation building. Public education in Malaysia--particularly, but not exclusively, at the pre-university level--is promoted as a nation-building tool, seeking to inculcate a sense of Malaysian-ness and patriotism. Simultaneously, however,…

In-situ evaluation of design parameters and procedures for cementitiously treated weak subgrades using cyclic plate load tests : project capsule.

DOT National Transportation Integrated Search

2013-06-01

Due to the soft nature of subsurface soils in southern Louisiana, roads often have to : be constructed on very weak subgrade soils with high in-situ moisture contents that : do not have the suffi cient strength/stiff ness to support the construction/...

Predictive Validity and Accuracy of Oral Reading Fluency for English Learners

ERIC Educational Resources Information Center

Vanderwood, Michael L.; Tung, Catherine Y.; Checca, C. Jason

2014-01-01

The predictive validity and accuracy of an oral reading fluency (ORF) measure for a statewide assessment in English language arts was examined for second-grade native English speakers (NESs) and English learners (ELs) with varying levels of English proficiency. In addition to comparing ELs with native English speakers, the impact of English…

Mapping Earth's electromagnetic dimensionality

NASA Astrophysics Data System (ADS)

Love, J. J.; Kelbert, A.; Bedrosian, P.

2017-12-01

The form of a magnetotelluric impedance tensor, obtained for a given geographic site through simultaneous measurement of geomagnetic and geoelectric field variation, is affected by electrical conductivity structure beneath the measurement site. Building on existing methods for characterizing the symmetry of magnetotelluric impedance tensors, a simple scalar measure is developed for measuring the (frequency dependent) proportion of the impedance tensor that is not just a one-dimensional (1D) function of depth ("non-1D-ness"). These measures are applied to nearly 1000 impedance tensors obtained during magnetotelluric surveys, those for the continental United States and obtained principally through the National Science Foundation's EarthScope project. Across geomagnetic/geoelectric variational periods ranging from 30 s to 3,000 s, corresponding to crustal and upper mantle depths, it is shown that local Earth structure is very often not simply 1D-depth-dependent - often less than 50% of magnetotelluric impedance is 1D. For selected variational frequencies, non-1D-ness is mapped and the relationship between electromagnetic dimensionality and known geological and tectonic structures is discussed. The importance of using realistic surface impedances to accurately evaluate magnetic-storm geoelectric hazards is emphasized.

Do optimally ripe blackberries contain the highest levels of metabolites?

PubMed

Mikulic-Petkovsek, Maja; Koron, Darinka; Zorenc, Zala; Veberic, Robert

2017-01-15

Five blackberry cultivars were selected for the study ('Chester Thornless', 'Cacanska Bestrna', 'Loch Ness', 'Smoothstem' and 'Thornfree') and harvested at three different maturity stages (under-, optimal- and over-ripe). Optimally ripe and over-ripe blackberries contained significantly higher levels of total sugars compared to under-ripe fruit. 'Loch Ness' cultivar was characterized by 2.2-2.6-fold higher levels of total sugars than other cultivars and consequently, the highest sugar/acids ratio. 'Chester Thornless' stands out as the cultivar with the highest level of vitamin C in under-ripe (125.87mgkg(-1)) and optimally mature fruit (127.66mgkg(-1)). Maturity stage significantly affected the accumulation of phenolic compounds. The content of total anthocyanins increased for 43% at optimal maturity stage and cinnamic acid derivatives for 57% compared to under-ripe fruit. Over-ripe blackberries were distinguished by the highest content of total phenolics (1251-2115mg GAE kg(-1) FW) and greatest FRAP values (25.9-43.2mM TE kg(-1) FW). Copyright © 2016 Elsevier Ltd. All rights reserved.

A non-canonical mechanism for Crm1-export cargo complex assembly.

PubMed

Fischer, Ute; Schäuble, Nico; Schütz, Sabina; Altvater, Martin; Chang, Yiming; Faza, Marius Boulos; Panse, Vikram Govind

2015-04-21

The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP. To ensure efficient cargo release in the cytoplasm, NESs have evolved to display low affinity for Crm1. However, mechanisms that overcome low affinity to assemble Crm1-export complexes in the nucleus remain poorly understood. In this study, we reveal a new type of RanGTP-binding protein, Slx9, which facilitates Crm1 recruitment to the 40S pre-ribosome-associated NES-containing adaptor Rio2. In vitro, Slx9 binds Rio2 and RanGTP, forming a complex. This complex directly loads Crm1, unveiling a non-canonical stepwise mechanism to assemble a Crm1-export complex. A mutation in Slx9 that impairs Crm1-export complex assembly inhibits 40S pre-ribosome export. Thus, Slx9 functions as a scaffold to optimally present RanGTP and the NES to Crm1, therefore, triggering 40S pre-ribosome export. This mechanism could represent one solution to the paradox of weak binding events underlying rapid Crm1-mediated export.

Survey of compressions in the SW (1 AU), and after termination shock at Voyager (in sheath & LISM)

NASA Astrophysics Data System (ADS)

Berdichevsky, D. B.

2017-12-01

Examples of the plasma compression as it is observed in the solar wind at 1 AU with the suite of instruments in the SC Wind, and after the termination shock with both Voyager SC, as well as with Voyager 1 in the local interstellar medium (LISM) are presented. The work will focus on similarities and differences in the observations at the different locations. At priory is fair to mention that the 4 regions differ in several aspects. At 1 AU the solar wind (SW) flow is mostly alfvenic. In the sheath after the termination shock the possibly subsonic solar wind is mostly compressional but fluctuation modes in scales of one hour are much less observed at Voyager 1 than at Voyager 2 path. Finally Burlaga and Ness1 documented the nature of the compressional flow in the `depletion' layer at the start of the LISM as well later in this medium, showing the low plasma-beta character of this LISM region in Voyager 1 path. 1Burlaga L.F., and N. Ness, ApJ, 784, 146 (14pp), 2014.

Living better with dementia: strengths-based social work practice and dementia care.

PubMed

McGovern, Justine

2015-01-01

This article first argues that quality of life is possible despite the onset of dementia in late life. It also demonstrates how core concepts of social work practice, such as family systems theory, the strengths perspective, and use of self, can be applied to practice with dementia-affected persons. In addition, it provides practical suggestions for supporting care partners in nurturing "we-ness", focusing on what remains rather than was is lost, and remaining authentic. When strengths-based social work practice is integrated into dementia care protocols, wellbeing can increase. As a result, the more than 40 million persons worldwide who are affected by dementia do not have to resign themselves to the despair, devastation and inevitable demise of quality of life that dominate perception of the illness.

Program Manager: Journal of the Defense Systems Management College. Volume 22, Number 2, DSMC 113. Repairing the DoD/Industry Partnership. March - April, 1993.

DTIC Science & Technology

1993-04-01

A;I r- c’I r- ’ Ae g-eac f ivenesSestr" 2’ý U c US ""’ c’ U SsS A ’ 3-a, ""r - Pedo ~~~~~e Ade~aU cl; a ," Marc ý4’ SAM-o"’ Rý 310C, ’at ’~ ">c ýxca-or...customer savs it is."• The second inherent concept is a Paradigm. Joel Barker. in his video tape Discovering the Future: The Busi- ness of Paradigms...management. I The company managemcnt philoso- viewed Tom Peters’ video tape entitled phv can be sunmnmarized in terms I will In Search of Excellence

Stress Judgment and Production in English Derivation, and Word Reading in Adult Mandarin-Speaking English Learners

ERIC Educational Resources Information Center

Chung, Wei-Lun; Jarmulowicz, Linda

2017-01-01

For monolingual English-speaking children, judgment and production of stress in derived words, including words with phonologically neutral (e.g., -ness) and non-neutral suffixes (e.g., "-ity"), is important to both academic vocabulary growth and to word reading. For Mandarin-speaking adult English learners (AELs) the challenge of…

Relationships, Being-ness, and Voice: Exploring Multiple Dimensions of Humanizing Work with Black Girls

ERIC Educational Resources Information Center

Edwards, Erica; McArthur, Sherell A.; Russell-Owens, LaToya

2016-01-01

This work argues for an approach to research and education practices that considers the historically deficit-based research practices and views on Black girls and develops humanizing research methods that consider the multiple oppressions that act as barriers for this group. Research must acknowledge the precarious position of Black girls in order…

Toward an Objectivistic Theory of Probability

DTIC Science & Technology

1956-01-01

OBJECTIVISTIC PROBABILITY THEORY 2 7 three potential acts: the individual may choose an apple, an orange or a banana . Each of these acts corresponds to a point...its veneer having begun to peel at one corner, etc., etc. Its future there-ness lies in that it may have its legs gnawed at by the new puppy in the

The Use of Academic Words in the Analytical Writing of Secondary English Learners and Native English Speakers

ERIC Educational Resources Information Center

Cons, Andrea M.

2013-01-01

This study explores the following research question: How do secondary English learners (ELs) and Re-designated fluent English proficient students (RFEPs) use academic words in analytical writing in comparison to native English speakers (NESs)? It highlights previously overlooked differences in academic word use in the writing of students who are…

Human and Organizational Effectiveness: A Total Spectrum Model.

DTIC Science & Technology

1983-09-01

performance , commitment, and satisfaction ; a phenomenon first detected during the well- known Hawthorne studies (Roethlisberger and Dickson 1939). Several...typically concentrated on explaining one of three general types of behavioral criteria: (a) performance , (b) job or need satisfaction , and (c...situation, and that directly influences dependent or criterion variables such as performance , satisfaction , effective- ness, and morale. Of particular

Monuments to the Republic: School as a Nationalising Discourse in Turkey

ERIC Educational Resources Information Center

Bilgi, Sabiha

2014-01-01

This article examines the cultural construction of the school in Turkey in relation to the construction of Turkish nation-ness. By looking at how the modern school was fit together with a network of interrelated discourses available in early twentieth-century Turkey, the article investigates the ways in which the school became an object of thought…

Foulois and the U.S. Army Air Corps 1931-1935,

DTIC Science & Technology

1983-01-01

IOUIlOIS AN) T14 U.S. ARMY AIR CORPS been reinoed , and implied that additional cuts wkould endanger the future security of the United States. The Chief...inst ruments or ra- dios . but these items s\\%ere absolutely a must for air mail operations. \\lili- tar\\ a\\ iators pri,’ed light ness and

Resistance and Invention: Becoming Academic, Remaining Other

ERIC Educational Resources Information Center

Brooks, Spirit; Franklin-Phipps, Asilia; Rath, Courtney

2018-01-01

In this paper, we take an unsanctioned academic network, a writing group, as a site of inquiry into both the broad given-ness of the norms of the neoliberal academy and our simultaneous compliance with and resistance to these norms. We choose to comply because we are invested in becoming academics; we continue to research and write for conferences…

Conducting Qualitative Data Analysis: Qualitative Data Analysis as a Metaphoric Process

ERIC Educational Resources Information Center

Chenail, Ronald J.

2012-01-01

In the second of a series of "how-to" essays on conducting qualitative data analysis, Ron Chenail argues the process can best be understood as a metaphoric process. From this orientation he suggests researchers follow Kenneth Burke's notion of metaphor and see qualitative data analysis as the analyst systematically considering the "this-ness" of…

Statistical mechanics and combinatorics of some discrete lattice models

NASA Astrophysics Data System (ADS)

Ayyer, Arvind

Many problems in statistical physics involve enumeration of certain objects. In this thesis, we apply ideas from combinatorics and statistical physics to understand three different lattice models. (I) We investigate the structure of the nonequilibrium stationary state (NESS) of a system of first and second class particles on L sites of a one-dimensional lattice in contact with first class particle reservoirs at the boundary sites and second class particles constrained to lie the system. The internal dynamics are described by the usual totally asymmetric exclusion process (TASEP) with second class particles. We show in a conceptually simple way how pinned and unpinned (fat) shocks determine the general structure of the phase diagram. We also point out some unexpected features in the microscopic structure of the NESS both for finite L and in the limit L → infinity. In the latter case the local distribution of second class particles is given by an equilibrium pressure ensemble with a pair potential between neighboring particles which grows logarithmically with distance. (II) We model a long linear polymer constrained between two plates as a walk on a two-dimensional lattice constrained to lie between two lines, x = y and x = y+w, which interacts with these lines via contact parameters s and t. The atomic steps of the walk can be taken to be from an arbitrary but fixed set S with the only condition being that the first coordinate of every element in S is strictly positive. For any such S and any w, we prescribe general algorithms (fully implemented in Maple) for the automated calculation of several mathematical and physical quantities of interest. (III) Ferrers (or Young) diagrams are very classical objects in representation theory, whose half-perimeter generating function of Ferrers diagrams is a straightforward rational function. We construct two new classes of Ferrers diagrams, which we call wicketed and gated Ferrers diagrams, which have internal voids in the shape of Ferrers diagrams, and calculate their half-perimeter generating functions, one of which is closely related to the generating function of the Catalan numbers, using a more abstract version of the usual transfer matrix method.

Accounting for Every Kilowatt

DTIC Science & Technology

2014-10-01

accountability of individual load con- sumption, forewarning of maintenance problems, and aware- ness of human activity based on electrical activity...accountability and maintenance examples were identified from our desks at MIT. Tech support can be anywhere and do the same. Human Activity DepNILM...provides awareness of human activity within a net- work. Each device has an electrical fingerprint, and specific de- vices imply associated human actions

Youth Attitude Tracking Study II, Wave 15 - Fall 1984.

DTIC Science & Technology

1985-04-01

key component of the Joint Market Research Program which contributes to policy formation and the development of recruiting marketing strategies . The...unrelated to advertising awareness for young males, but positive propensity females have higher aware- ness of advertising . * Majorities in each market group... advertising programs * Examine the potential effect of enlistment incentives on propensity to enlist Develop further the market segmentation analysis

The Effects of Pilot Age, Lighting, and Head-Down Time on Visual Accommodation

DTIC Science & Technology

1979-02-06

technique for determining the extent of ametropia (nearsighted- ness, farsightedness, astigmatism) and as an aid in the fitting (8.1)of eyeglasses. Knoll... Ametropia with a Gas LASER", "Amerinan 1onu~nl nf Onpw’rp"r-_ Vol. 43, No. 7: 415-418, 1966. 4. Oliver, G. M. "Sparkling Spots and Random Diffractions

Automatic Synthesis of Fine-Motion Strategies for Robots.

DTIC Science & Technology

1983-12-01

ADA-A39 532 AUTOMATI CSYNTHESISOF FNE-MOTIONSTRATEGIESFORa R080 S(U) MASSACHUSETTS INS OF TECH CAMBRIDOE ARTIFCIAL INTELLGENCE LAB IOZANO-PEREZ DEC...N00014-82-K-0334 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK Artificial Intelligence Laboratory AREA...provides correct- ness criteria for compliant motion strategies. MASSACHUSETTS INSTITUTE OF TECHNOLOGY ARTIFICIAL INTELLIGENCE LABORATORY A. I. MEMO 759

10.6 Micrometer Absorption in Molybdenum Mirrors

DTIC Science & Technology

1974-07-01

laser damage studies. Interferometric versus stylus instrument measurement of surface rough- ness is discussed. The polishing and coating procedures are...preliminary CW laser damage studies. Interferometric versus stylus instrument measurement of surface roughness is discussed. The polishing and coating...contrast ( Nomarski ) microscopic invescigations were made of th. surface. Figue 3 presents Nomarski photographs of mirrors M-107 through M-109. M-108

How Do Roots and Suffixes Influence Reading of Pseudowords: A Study of Young Italian Readers with and without Dyslexia

ERIC Educational Resources Information Center

Traficante, Daniela; Marcolini, Stefania; Luci, Alessandra; Zoccolotti, Pierluigi; Burani, Cristina

2011-01-01

The study explored the different influences of roots and suffixes in reading aloud morphemic pseudowords (e.g., vetr-ezza, "glass-ness"). Previous work on adults showed a facilitating effect of both roots and suffixes on naming times. In the present study, pseudoword stimuli including roots and suffixes in different combinations were…

On Literature's Use(ful/less)ness: Reconceptualizing the Literature Curriculum in the Age of Globalization

ERIC Educational Resources Information Center

Choo, Suzanne S.

2011-01-01

This paper begins by examining how debates about literature's usefulness or, more specifically, its uselessness, have been framed in terms of the binary between utilitarianism and pragmatism on the one hand, and between humanism and idealism on the other. Instead of conceiving the literature curriculum in terms of a position one privileges in a…

A non-canonical mechanism for Crm1-export cargo complex assembly

PubMed Central

Fischer, Ute; Schäuble, Nico; Schütz, Sabina; Altvater, Martin; Chang, Yiming; Boulos Faza, Marius; Panse, Vikram Govind

2015-01-01

The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP. To ensure efficient cargo release in the cytoplasm, NESs have evolved to display low affinity for Crm1. However, mechanisms that overcome low affinity to assemble Crm1-export complexes in the nucleus remain poorly understood. In this study, we reveal a new type of RanGTP-binding protein, Slx9, which facilitates Crm1 recruitment to the 40S pre-ribosome-associated NES-containing adaptor Rio2. In vitro, Slx9 binds Rio2 and RanGTP, forming a complex. This complex directly loads Crm1, unveiling a non-canonical stepwise mechanism to assemble a Crm1-export complex. A mutation in Slx9 that impairs Crm1-export complex assembly inhibits 40S pre-ribosome export. Thus, Slx9 functions as a scaffold to optimally present RanGTP and the NES to Crm1, therefore, triggering 40S pre-ribosome export. This mechanism could represent one solution to the paradox of weak binding events underlying rapid Crm1-mediated export. DOI: http://dx.doi.org/10.7554/eLife.05745.001 PMID:25895666

Loch ness, special operations executive and the first surgeon in paradise: Robert Kenneth Wilson (26.1.1899-6.6.1969).

PubMed

Watters, David A K

2007-12-01

Lieutenant Colonel Robert Kenneth Wilson (1899-1969) was a surgeon who fought in both world wars and joined the Special Operations Executive parachuting behind enemy lines into Holland, France and Borneo, the last mission being with Australian forces (Semut II). He was an expert on firearms and gave opinion on ballistics at the Old Bailey during the 1930s. He also wrote a definitive text on automatic pistols with editions published in 1943 and 1975. He was an Edinburgh Fellow (1926), who had a practice in general surgery and gynaecology in Queen Anne Street during the 1930s. He took the famous 1934 'surgeon's photo' of the Loch Ness monster that was not admitted to be a hoax until 1994. After World War II, he became the first surgical specialist to work in the public service of the then Territory of Papua and New Guinea (1950-1956), where he wrote several papers on surgical topics. He married Gwen (1924), the daughter of Henrietta Gulliver, an Australian painter. They had two sons, Richard and Phillip. After practice he retired to Melbourne where he died of carcinoma oesophagus.

[Which factors determine the altitudinal distribution of tropical Andean riverine fishes]?

PubMed

De La Barra, Evans; Zubieta, José; Aguilera, Gastón; Maldonado, Mabel; Pouilly, Marc; Oberdorff, Thierry

2016-03-01

Altitudinal gradients represent an appropriate system to assess whether there is a relationship between richness patterns, environmental variables, and the ecological processes that determine the species type and number inhabiting a given area. In mountain streams freshwater fishes, the most prevalent relationship is a monotonic decrease in species richness with elevation. The objective of this study was to evaluate four hypotheses that can explain the negative relationship between local fish species richness and altitude, 1) the hypothesis of decreasing energy availability, 2) the hypothesis of increasing climate severity, 3) the hypothesis of habitat diversity, and 4) the hypothesis of isolation by physical severity of the environment. Fish and macro-invertebrates were collected following standard methods from 83 sites (between 200-4 000 meters) of two river basins in the Bolivian Amazon. The first hypothesis was tested by analyzing relationships between the density of macro-invertebrates, the richness of invertivorous fish species and altitude; while the second and third hypotheses were assessed by a multiple regression analysis (GLM) between fish species richness and several local and regional factors. Besides, assemblage dissimilarity between sites along the altitudinal gradient was analyzed using βsim and βness indices. Fish richness decreases linearly with increasing altitude. The density of macro-invertebrates tends to increase at higher altitudes, contrary to invertivorous fish species richness, suggesting that energy availability is not a limiting factor for fish species colonization. The GLM explained 86 % of the variation in fish species richness, with a significant contribution of water temperature, maximum slope in the river mainstem, and stream width. There is a higher species turnover (βsim) between sites at low elevation. Inversely, βness shows higher values in the upper parts, corresponding to change in assemblages mainly due to species loss. Taken together, these results suggest that climatic and physical severities create strong barriers to colonization, further explaining the decrease in fish richness along the altitudinal gradient.

Development of a Model Competency-Based Orientation Program

DTIC Science & Technology

1988-05-01

S. (1938). Basic writings of Sigmund Freud . New York: Random House. Hagerty, B.K. (1986). A competency-based orientation program for psychiatric...education, and nursing will be presented. • ..... Beginning with the field of psychology, Freud (1938) described motivation using the concept of psychic...Gosnell, D.J. (1987). Comparing two methods of hospital orientation for cost effective- ness. Journal of Nursing Staff Development, 3 , 3-8. Freud

Node Ranking Tool - NoRT

DTIC Science & Technology

2018-03-23

Unclassified Unlimited Unclassified Unlimited Unclassified Unlimited 23 Ira S. Moskowitz (202) 404-7930 This paper gives a description of the Node Ranking Tool...Disease, Virus, Expectation, Pandemic, Close- ness, Graph, Degree, Spectrum. I. INTRODUCTION THis paper gives a description of the Node Ranking Tool...is very much dependent upon which centrality measure we use. Therefore, following [6] and [3], we use TOPSIS to evaluate our decisions about the

A Qualitative Comparative Analysis Exploring How the Arrangement of Higher Education Governance Shapes the Contribution of Two-Year Institutions to State Educational Attainment

ERIC Educational Resources Information Center

White, Carol Cutler

2016-01-01

Two-year institutions of higher education are critical to state educational attainment (Auguste, Cota, Kartik, & Laboissiere, 2010; Wildavsky, Kelly, & Carey, 2011c), but the institutions may be hindered in contributing to attainment increases by the arrangement of governance (McLendon & Ness, 2003). The purpose of the study was to…

Command and Control for War and Peace

DTIC Science & Technology

1992-01-01

segments of the information busi - ness, as well as organizations that are consumers of information. Competing industries and competitors within... business from a broad, conceptual viewpoint. Each of the practitioners tends to see the process from perspectives that vary widely and at the frequent...that must eventually emerge from schol- arly treatment of the business and take an enduring form for future and aspiring practitioners to study, Senior

JPRS Report, China

DTIC Science & Technology

1989-08-21

as dried noodles , cut noodles , and rice flour, they did not carry large quantities. Following the 3d Plenary Session of the 11th Party Central...of economic diversification. Second, city grain shops made do with whatever was available for the mass processing of cut noodles , dried noodles ...still condone short- term behavior throughout society, including our eager- ness for quick success and instant benefits in economic growth? It

Defense Standardization Program Journal, July/December 2007

DTIC Science & Technology

2007-12-01

during the standard next review cycle, and identified areas where supplemental standards are needed. ENTERPRISE POWER SECURITY AND CONTINUITY Continual...availability of electric power at the enterprise level is essential for busi- ness functions, safety, and the public well-being.Yet many practical...challenges exist related to keeping critical operations, equipment, or facilities powered when the Peieeaeuiyivle ail ad acn teholg tatsnee electric grid is

A Compendium of Arctic Environmental Information

DTIC Science & Technology

1986-03-01

warn- ing of possible future ice invasions during petroleum drill - ing operations in open-water conditions. Development of sea ice Several basic...tubes, triple beam balance snow temperature thermistor and bridge ice ttiicl^ness hand auger, electric drill with auger, tape with toggle ice...fluids, 8 quarts daily. Acidify urine by drink- ing cranberry juice, taking Vitamin C, etc. Machines All machinery in the Arctic (engines, drills

Silicon Solar Cell Optimization.

DTIC Science & Technology

1981-06-01

from the surface. (b) Oxide mask formation Etching grooves into the silicon requires an effective alkaline-resistant mask which will withstand the...face. This technique employs a very viscous photoresist, Furt #206, in conjunction with multiple spin-applications and bake periods, to effectively ...175 80 125 78 75 74 To compare the effects of groove depth, substrate thick- ness and bulk resistivity, an experiment was conducted. Using identical

Modeling of Spark Gap Performance

DTIC Science & Technology

1983-06-01

MODELING OF SPARK GAP PERFORMANCE* A. L. Donaldson, R. Ness, M. Hagler, M. Kristiansen Department of Electrical Engineering and L. L. Hatfield...gas pressure, and chaJ:ging rate on the voltage stability of high energy spark gaps is discussed. Implications of the model include changes in...an extremely useful, and physically reasonable framework, from which the properties of spark gaps under a wide variety of experimental conditions

Capacity-Building Efforts by the AFHSC-GEIS Program

DTIC Science & Technology

2011-01-01

and equipment support was provided to over 500 field sites in 74 countries worldwide from October 2008 to September 2009. These activities allowed...and equipment support was provided to over 500 field sites in 74 countries worldwide from October 2008 to September 2009. These activities allowed...other vector-borne ill- nesses, acute diarrheal diseases, antimalarial and antimi- crobial resistance, sexually transmitted diseases, and bacterial

JPRS Report, Science & Technology, Europe, FRG: Official Report om Multiyear Research Funding, Trends

DTIC Science & Technology

1988-08-23

research institutions. The special recognition of performance and the chal- lenge to top performance in research, development, and innovation will...continue to be a central concern of the federal government. Top performances , the achievement of internationally recognized breakthroughs, and suc...government places on improving busi- ness framework conditions for more growth and employ- ment, for strengthening the power of performance , com

Innovative Solidification Techniques for Hazardous Wastes at Army Installations.

DTIC Science & Technology

1985-11-01

Fixed Hazardous Industrial Wastes and Flue Gas Desulfurization Sludges," Interim Report, EPA-600/2-76-182, US Environmental Protection Agency... flue gas . Flyash from coal-fired power plants is an almost entirely inorganic product having a glassy nature. Consequently, flyash by itself has little...effective- ness of alternative control strategies for reducing environmental impacts. 4. % 46 -"- °° ~~~~~...-.-..o

Laser Covariance Vibrometry for Unsymmetrical Mode Detection

DTIC Science & Technology

2006-09-01

surface rough- ness. Results show that the remote sensing spectra adequately match the structural vibration, including non – imaging spatially...the speckle. 10 profile (cross – section), is an air turbulence effect ignored in this work that will affect both the sensed vibration phase change and...like spike impulse. 13 Chapter three describes optical processing issues. This chapter delineates the image propagation algorithms used for the work

Syntactic Complexity and L2 Academic Immersion Effects on Readers' Recall and Pausing Strategies for English and Spanish Texts

ERIC Educational Resources Information Center

Lazarte, Alejandro A.; Barry, Sue

2008-01-01

In Experiment 1, monolingual native Spanish speakers (NSSs) had better kernel recall and longer end-of-clause (EOC) pauses than native English speakers (NESs) when reading texts that varied in syntactic complexity as a function of the number of nonessential clauses added to the kernel text. NSS familiarity with embedded clauses in Spanish seem to…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matsuda, M.; Sugihara, T.; Kakehi, Y.

Strong moriamine S, a type of amino-acid preparation, was administercd intravenously to patients receiving radiation therapy. In all cases symptoms of radiation sick ness appeared to be moderately improved. After the injection of this agent leukopoiesis improved in 60% of the patients. Strong moriamine S is considered to be one of the effective agents for the therapy of radiation sickness and leucopenia following irradiation. (Abstr. Japan. Med., 1: No. 1, 1960)

Non-equilibrium phase transition in mesoscopic biochemical systems: from stochastic to nonlinear dynamics and beyond

PubMed Central

Ge, Hao; Qian, Hong

2011-01-01

A theory for an non-equilibrium phase transition in a driven biochemical network is presented. The theory is based on the chemical master equation (CME) formulation of mesoscopic biochemical reactions and the mathematical method of large deviations. The large deviations theory provides an analytical tool connecting the macroscopic multi-stability of an open chemical system with the multi-scale dynamics of its mesoscopic counterpart. It shows a corresponding non-equilibrium phase transition among multiple stochastic attractors. As an example, in the canonical phosphorylation–dephosphorylation system with feedback that exhibits bistability, we show that the non-equilibrium steady-state (NESS) phase transition has all the characteristics of classic equilibrium phase transition: Maxwell construction, a discontinuous first-derivative of the ‘free energy function’, Lee–Yang's zero for a generating function and a critical point that matches the cusp in nonlinear bifurcation theory. To the biochemical system, the mathematical analysis suggests three distinct timescales and needed levels of description. They are (i) molecular signalling, (ii) biochemical network nonlinear dynamics, and (iii) cellular evolution. For finite mesoscopic systems such as a cell, motions associated with (i) and (iii) are stochastic while that with (ii) is deterministic. Both (ii) and (iii) are emergent properties of a dynamic biochemical network. PMID:20466813

Observed Reduction In Surface Solar Radiation - Aerosol Forcing Versus Cloud Feedback?

NASA Astrophysics Data System (ADS)

Liepert, B.

The solar radiation reaching the ground is a key parameter for the climate system. It drives the hydrological cycle and numerous biological processes. Surface solar radi- ation revealed an estimated 7W/m2 or 4% decline at sites worldwide from 1961 to 1990. The strongest decline occurred at the United States sites with 19W/m2 or 10%. Increasing air pollution and hence direct and indirect aerosol effect, as we know today can only explain part of the reduction in solar radiation. Increasing cloud optical thick- ness - possibly due to global warming - is a more likely explanation for the observed reduction in solar radiation in the United States. The analysis of surface solar radiation data will be shown and compared with GCM results of the direct and indirect aerosol effect. It will be argued that the residual declines in surface solar radiation is likely due to cloud feedback.

A Sensemaking Perspective on Situation Awareness in Power Grid Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greitzer, Frank L.; Schur, Anne; Paget, Mia L.

2008-07-21

With increasing complexity and interconnectivity of the electric power grid, the scope and complexity of grid operations continues to grow. New paradigms are needed to guide research to improve operations by enhancing situation awareness of operators. Research on human factors/situation awareness is described within a taxonomy of tools and approaches that address different levels of cognitive processing. While user interface features and visualization approaches represent the predominant focus of human factors studies of situation awareness, this paper argues that a complementary level, sensemaking, deserves further consideration by designers of decision support systems for power grid operations. A sensemaking perspective onmore » situation aware-ness may reveal new insights that complement ongoing human factors research, where the focus of the investigation of errors is to understand why the decision makers experienced the situation the way they did, or why what they saw made sense to them at the time.« less

A Video Game for Cyber Security Training and Awareness

DTIC Science & Technology

2006-01-01

potentially mundane. Video games have been proposed as an engaging training vehicle (Prenski, 2001). Here we describe a video game-like tool called Cyber- CIEGE...formation assurance, and information assurance technolo- gists with little background in video games . Early focus was on establishing a language that... video games or adventure games appear more inclined to explorethe game, sometimes proceeding beyond the simple aware- ness scenarios into more

Aircraft Survivability: Survivability 2000, On A Heading for Success, Spring 2000

DTIC Science & Technology

2000-01-01

susceptibility to attack, vulnerability from attack, and overall combat effective - ness as the legislation establishing LFT&E requires. Our goal now is to set the...Munitions Effectiveness (JTCG/ME) to the Office of the Director, Operational Test and Evaluation (DOT&E), with management oversight from the Deputy...reduction—combined with standoff jamming, electromagnetic countermeasures (ECM) to degrade threat effective n e s s, and platform vulnerability reduc

Defense Standardization Program Journal. October/December 2011

DTIC Science & Technology

2011-12-01

34 tends to yield a negative con - notation, because some people may believe that a mistake or failure has occurred. But, in fact, lessons learned are...to further refine processes or pro - cedures. In order for coalition partners and al- lies to meet the demands of a changing global environment...other things, those stakeholders conducted a SWOT (strengths, weak- nesses, opportunities, threats) analysis to help identify practicable options. The

Improving the Selection, CLassification and Utilization of Army Enlisted Personnel

DTIC Science & Technology

1992-11-01

installations. These jobs were grouped into one combat (11B, 13B, and 19E NOS) and three non -combat clusters [Cleri- cal (71L MOS), Operations (31C...factor contains items from the Non -delinquency, Traditional Values, Conscientiousness, Cooperative- ness, and Internal Control scales. The Adjustment...validities and success rates for various groups of cases: all males, females, graduate males, and non -graduate males. Table 3 Descriptive statistics

Consistent Criteria are Needed to Assess Small-Business Innovation Initiatives.

DTIC Science & Technology

1981-07-07

Federal programs designed to provide funding or technical and management assistance directly to small busi - nesses (such as the National Science...activities to support small businesses as innovators 33 Efforts to influence economy-wide factors 35 Programs that provide funding or management and... Management : A Guide to Entrepreneurship (Boston: Houghton Mifflin, 1977), p. 61. 2/H. Stoll and J. Walter, Tax Incentives for Small Businesses (Chicago

Ultraviolet B Irradiance and Incidence Rates of Bladder Cancer in 174 Countries

DTIC Science & Technology

2010-03-01

Hungary, Ireland, Iran, Kuwait, Laos, Latvia, Lebanon, Micronesia, Malaysia , Myanmar, Namibia, Nigeria, Nicaragua, Niger, Korea Democratic Republic...these are the best available data sources for the covariates. Further, this study could not account for differences in culture, behavior, and diet ...ness. Photochem Photobiol2005Jll(6):1287-90. Punnonen R, Gillespy M, Hahl M. Serum 25-0HD, vitamin A and vitamin E concentrations in healthy Finnish

Stochastic Control of Multi-Scale Networks: Modeling, Analysis and Algorithms

DTIC Science & Technology

2014-10-20

Theory, (02 2012): 0. doi: B. T. Swapna, Atilla Eryilmaz, Ness B. Shroff. Throughput-Delay Analysis of Random Linear Network Coding for Wireless ... Wireless Sensor Networks and Effects of Long-Range Dependent Data, Sequential Analysis , (10 2012): 0. doi: 10.1080/07474946.2012.719435 Stefano...Sequential Analysis , (10 2012): 0. doi: John S. Baras, Shanshan Zheng. Sequential Anomaly Detection in Wireless Sensor Networks andEffects of Long

A Comprehensive Approach to Combating Illicit Trafficking

DTIC Science & Technology

2010-06-01

that are “out of government control, and too scary for investors and tourists ,” firearms: US to Mexico ivory: Africa to Asia stolen identity...necessarily reflect those of DTRA, the U.S. Government , NATO, or any other national or intergovernmental agency. For further information on this report...operations in remote and poor- ly governed areas, where they can conduct busi- ness relatively free of outside interference. They appear to be especially

Distance Metric Tracking

DTIC Science & Technology

2016-03-02

some close- ness constant and dissimilar pairs be more distant than some larger constant. Online and non -linear extensions to the ITML methodology are...is obtained, instead of solving an objective function formed from the entire dataset. Many online learning methods have regret guarantees, that is... function Metric learning seeks to learn a metric that encourages data points marked as similar to be close and data points marked as different to be far

"A Tale of Two Programs": Interrogating "Open(closed)ness" and "Cultural Diversity" through Critical Observations of Two Japanese University English Language Programs

ERIC Educational Resources Information Center

Toh, Glenn

2015-01-01

Japan is known to be a country that manicures its socio-cultural borders. In this article I will examine discourses regarding openness, closedness and cultural diversity in relation to policies and practices that draw heavily on mythologies of English language as an inroad to greater openness and diversity. To do this I will examine two English…

Saksenaea erythrospora Infection Following Combat Trauma

DTIC Science & Technology

2011-10-01

partial-thickness and full-thick- ness burns affecting his head, arms, and legs. No evidence of significant smoke inhalation injury was noted on...extract-water culture at 35°C. The water culture remained sterile after 4 weeks; however, a few fruiting structures were seen on the CZA plate and the...weeks of incubation at 25°C. (B) Fruiting structure of S. erythrospora depicting lateral rhizoids; a brown, straight, encrusted sporangiophore; the

Proteome-wide search for functional motifs altered in tumors: Prediction of nuclear export signals inactivated by cancer-related mutations

PubMed Central

Prieto, Gorka; Fullaondo, Asier; Rodríguez, Jose A.

2016-01-01

Large-scale sequencing projects are uncovering a growing number of missense mutations in human tumors. Understanding the phenotypic consequences of these alterations represents a formidable challenge. In silico prediction of functionally relevant amino acid motifs disrupted by cancer mutations could provide insight into the potential impact of a mutation, and guide functional tests. We have previously described Wregex, a tool for the identification of potential functional motifs, such as nuclear export signals (NESs), in proteins. Here, we present an improved version that allows motif prediction to be combined with data from large repositories, such as the Catalogue of Somatic Mutations in Cancer (COSMIC), and to be applied to a whole proteome scale. As an example, we have searched the human proteome for candidate NES motifs that could be altered by cancer-related mutations included in the COSMIC database. A subset of the candidate NESs identified was experimentally tested using an in vivo nuclear export assay. A significant proportion of the selected motifs exhibited nuclear export activity, which was abrogated by the COSMIC mutations. In addition, our search identified a cancer mutation that inactivates the NES of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus. PMID:27174732

A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.

PubMed

García-Santisteban, Iraia; Arregi, Igor; Alonso-Mariño, Marián; Urbaneja, María A; Garcia-Vallejo, Juan J; Bañuelos, Sonia; Rodríguez, Jose A

2016-12-01

The exportin CRM1 binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm. Structural and biochemical analyses have uncovered the molecular mechanisms underlying CRM1/NES interaction. CRM1 binds NESs through a hydrophobic cleft, whose open or closed conformation facilitates NES binding and release. Several cofactors allosterically modulate the conformation of the NES-binding cleft through intramolecular interactions involving an acidic loop and a C-terminal helix in CRM1. This current model of CRM1-mediated nuclear export has not yet been evaluated in a cellular setting. Here, we describe SRV100, a cellular reporter to interrogate CRM1 nuclear export activity. Using this novel tool, we provide evidence further validating the model of NES binding and release by CRM1. Furthermore, using both SRV100-based cellular assays and in vitro biochemical analyses, we investigate the functional consequences of a recurrent cancer-related mutation, which targets a residue near CRM1 NES-binding cleft. Our data indicate that this mutation does not necessarily abrogate the nuclear export activity of CRM1, but may increase its affinity for NES sequences bearing a more negatively charged C-terminal end.

Long-term archiving and data access: modelling and standardization

NASA Technical Reports Server (NTRS)

Hoc, Claude; Levoir, Thierry; Nonon-Latapie, Michel

1996-01-01

This paper reports on the multiple difficulties inherent in the long-term archiving of digital data, and in particular on the different possible causes of definitive data loss. It defines the basic principles which must be respected when creating long-term archives. Such principles concern both the archival systems and the data. The archival systems should have two primary qualities: independence of architecture with respect to technological evolution, and generic-ness, i.e., the capability of ensuring identical service for heterogeneous data. These characteristics are implicit in the Reference Model for Archival Services, currently being designed within an ISO-CCSDS framework. A system prototype has been developed at the French Space Agency (CNES) in conformance with these principles, and its main characteristics will be discussed in this paper. Moreover, the data archived should be capable of abstract representation regardless of the technology used, and should, to the extent that it is possible, be organized, structured and described with the help of existing standards. The immediate advantage of standardization is illustrated by several concrete examples. Both the positive facets and the limitations of this approach are analyzed. The advantages of developing an object-oriented data model within this contxt are then examined.

Ground-water flow and quality in Wisconsin's shallow aquifer system

USGS Publications Warehouse

Kammerer, P.A.

1995-01-01

In terms of chemical quality, the water is suitable for potable supply and most other uses, but objectionable hardness in large areas and concen- trations of iron and manganese that exceed State drinking-water standards cause aesthetic problems that may require treatment of the water for some uses. Concentrations of major dissolved constitu- ents (calcium, magnesium, and bicarbonate), hard- ness, alkalinity, and dissolved solids are highest where the bedrock component of the aquifer is dolo- mite and lowest where the shallow aquifer is almost entirely sand and gravel. Concentrations of other minor constituents (sodium, potassium, sulfate, chloride, and fluoride) are less closely related to common minerals that compose the aquifer system. Sulfate and fluoride concentrations exceed State drinking-water standards locally. Extreme variability in concentrations of iron and manganese are common locally. Iron and manganese concentra- tions exceed State drinking-water standards in water from one-third and one-quarter of the wells, respectively. Likely causes of nitrate-nitrogen con- centrations that exceed State drinking-water stan- dards include local contamination from plant fertilizers, animal wastes, waste water disposed of on land, and septic systems. Water quality in the shallow aquifer system has been affected by saline water from underlying aquifers, primarily along the eastern and western boundaries of the State where the thickness of Paleozoic rocks is greatest.

Fluctuations When Driving Between Nonequilibrium Steady States

NASA Astrophysics Data System (ADS)

Riechers, Paul M.; Crutchfield, James P.

2017-08-01

Maintained by environmental fluxes, biological systems are thermodynamic processes that operate far from equilibrium without detailed-balanced dynamics. Yet, they often exhibit well defined nonequilibrium steady states (NESSs). More importantly, critical thermodynamic functionality arises directly from transitions among their NESSs, driven by environmental switching. Here, we identify the constraints on excess heat and dissipated work necessary to control a system that is kept far from equilibrium by background, uncontrolled "housekeeping" forces. We do this by extending the Crooks fluctuation theorem to transitions among NESSs, without invoking an unphysical dual dynamics. This and corresponding integral fluctuation theorems determine how much work must be expended when controlling systems maintained far from equilibrium. This generalizes thermodynamic feedback control theory, showing that Maxwellian Demons can leverage mesoscopic-state information to take advantage of the excess energetics in NESS transitions. We also generalize an approach recently used to determine the work dissipated when driving between functionally relevant configurations of an active energy-consuming complex system. Altogether, these results highlight universal thermodynamic laws that apply to the accessible degrees of freedom within the effective dynamic at any emergent level of hierarchical organization. By way of illustration, we analyze a voltage-gated sodium ion channel whose molecular conformational dynamics play a critical functional role in propagating action potentials in mammalian neuronal membranes.

Passive broadband targeted energy transfers and control of self-excited vibrations

NASA Astrophysics Data System (ADS)

Lee, Young S.

This work consists of the three main parts---Nonlinear energy pumping (that is, passive broadband targeted energy transfers---TETs), and its applications to theoretical and experimental suppression of aeroelastic instabilities. In the first part, nonlinear energy pumping (or TETs) in coupled oscillators is studied. The system is composed of a primary linear subsystem coupled through an essentially nonlinear stiffness and a linear viscous damper to an additional mass (which is called, as a whole, a nonlinear energy sink---NES). By considering the linear damping as a perturbation to the system, periodic solutions of the underlying Hamiltonian system are formulated by means of the non-smooth temporal transformation and solved numerically by a shooting method. The special periodic orbits, which are corresponding to the impulsive initial conditions for the primary subsystem, bear their importance as baits for initiating localized transfers of a significant portion of energy to the NES. The second part theoretically deals with suppression of limit cycle oscillations (LCOs) in self-excited systems by means of passive energy localizations. As a pilot scheme, suppression or even complete elimination of the LCO in a van der Pol (VDP) oscillator coupled with two types of NESS---grounded and ungrounded---is studied. Computational parametric study proves the efficacy of LCO elimination by means of passive nonlinear energy pumping from the VDP oscillator to appropriately designed NESs. The numerical study of the transient dynamics of the system showed that the dynamical mechanism for LCO suppression is a series of 1:1 and 1:3 transient resonance captures, with the damped transient dynamics following closely corresponding resonant manifolds of the underlying Hamiltonian system. It is through the TRCs that energy gets transferred from the VDP oscillator to the NES, thus causing LCO suppression. By performing an additional bifurcation analysis of the steady state responses through a numerical continuation of equilibria and periodic solutions, the parameter dependence and bifurcations of the steady-state solutions are examined. It is also proved that a Hopf bifurcation is the global dynamical mechanism for generation and elimination of the LCOs in the configurations considered. The bifurcation analysis revealed that it is possible to design grounded or ungrounded NESs that robustly and completely eliminate the LCO instability of the system. This should be possible when the system parameters are chosen such that a subcritical Hopf bifurcation occurs, thus assuring the existence of a unique global trivial attractor of the dynamics in the parameter ranges of interest. Then, triggering mechanisms of aeroelastic instability is investigated for a two-DOF rigid wing model in subsonic flow with cubic nonlinear stiffnesses at the support. Based on the observation of the instability triggering, a single-degree-of-freedom (SDOF) NES is applied to the wing model. The NES is attached at an offset from the elastic axis for its additional interaction with the pitch mode, as well as being parallel with the heave mode, primarily to hinder initial triggering of the heave mode by the flow. It is shown that it is feasible to partially or even completely suppress aeroelastic instabilities of the wing by passively transferring vibration energy from the wing to the NES in a one-way irreversible fashion. Moreover, this aeroelastic instability suppression is performed by partially or completely eliminating the triggering mechanists for aeroelastic suppression. Through numerical parametric studies three main mechanisms for suppressing aeroelastic instability are identified: (i) Recurring burst-out and suppression; (ii) intermediate suppression; (iii) complete elimination of instability. In general, the relative occurrence of one of the two limit point cycle (LPC) bifurcations with respect to the Hopf bifurcation decides whether or not the suppression mechanisms are robust. In order to improve robustness of instability suppression, several types of multi-DOF NES configurations are introduced. In the last part, experimental suppression of aeroelastic instability by means of targeted energy transfers is investigated. In order to gain insights into the experiments, theoretical triggering mechanism of the aeroelastic instability in the nonlinear aeroelastic test apparatus (NATA) in a low-speed wind tunnel at Texas A&M University is studied. Finally, experimental results are presented in connection to the theoretical investigation, and all the predictions on the instability suppression mechanisms are demonstrated experimentally. It is also revealed that the dry friction affects only the robustness of an instability suppression by changing the unstable trivial equilibrium into an equilibrium set. (Abstract shortened by UMI.)

JPRS Report, Soviet Union, Political Affairs.

DTIC Science & Technology

1988-10-13

to the realities , saying that Hitler would not commit a violation of the treaty. Stalin actually said that our intelligence agents could not be...in reality . Public trials elicited a certain feeling of fright—from the readi- ness to tell everything about oneself and to acknowledge everything...imagine the possibility of all this. But we knew how Stalin had walked behind the coffin of Kirov. We didn’t know what in reality had happened in

Effects of Extended Hypoxia on Night Vision

DTIC Science & Technology

1983-06-01

Continue on reverse aide it necessary and identify by block number) hypoxia, anoxia , night vision, dark adaptation, extended hypoxia /y虦 SABDST’RACT M=t...and his colleagues, who not only quantified significant aspects of the dark adaptation function due to anoxia (hypoxia) (12,13,14,16), but also...and his co-workers (7) conducted related and very significant research on bright- ness discrimination, and concluded that anoxia acts mainly on the

VizieR Online Data Catalog: APOGEE kinematics. I. Galactic bulge overview (Ness+, 2016)

NASA Astrophysics Data System (ADS)

Ness, M.; Zasowski, G.; Johnson, J. A.; Athanassoula, E.; Majewski, S. R.; Garcia Perez, A. E.; Bird, J.; Nidever, D.; Schneider, D. P.; Sobeck, J.; Frinchaboy, P.; Pan, K.; Bizyaev, D.; Oravetz, D.; Simmons, A.

2016-05-01

We use the APOGEE spectra (R=22500) from the SDSS-III Data Release 12 (DR12; Ahn et al. 2014ApJS..211...17A) for about 20000 stars toward the Galactic bulge and surrounding disk. The APOGEE survey, part of the SDSS-III project (Eisenstein et al. 2011AJ....142...72E), operates at the 2.5m telescope of the Apache Point Observatory. (1 data file).

"What is the Use of a Book without Pictures?" An Exploration of the Impact of Illustrations on Reading Experience in "A Monster Calls"

ERIC Educational Resources Information Center

Aggleton, Jen

2017-01-01

This article examines the effect of Jim Kay's illustrations on the experience of reading "A Monster Calls" by Patrick Ness. The author compares the responses of six Key Stage Three children (11-14 years old), three of whom were given an illustrated version of the text, and three a non-illustrated version. The children with an illustrated…

An Analysis of the Relationships of Personnel Characteristics to the Performance of DD 963 Class Ships.

DTIC Science & Technology

1983-12-01

problem equipment, supply support deficiencies , maintenance difficulties, etc., which tend to reduce the combat readi- ness of the Navy. CASREPs are...with Operation Reports Publication NVP 7. The severity codes are as follows: C-2 - (Substantially Ready) A deficiency exists in mission essential...equipment which causes a minor degradaticn in any primary mission area. C-3 - (Marginally Ready) a deficiency exists in mission essential equipment which

Physical Morphology and Quantitative Characterization of Chemical Changes of Weathered PVC/Pine Composites

DTIC Science & Technology

2009-12-22

occurred by oxidation process. Also, oxidation and lignin (from the wood) degradation influenced the color (light- ness) of PVC based WPC upon weathering...and lignin (from the wood) degradation influenced the color (lightness) of PVC based WPC upon weathering. 15. SUBJECT TERMS 16. SECURITY...with DEab. More importantly, previous report showed that color change in wood during weathering was due to the lignin degradation [33]. Infrared spectra

Military Enlistment and Attrition. An Analysis of Decision Reversal

DTIC Science & Technology

1987-06-01

instability, defined as being unemployed at the time of enlistment or having had a spell of jobless- ness within the past 12 months. For graduates, attrition...opportunities. The level of education an individual obtains is related to the value of higher education to the individual (both monetary and psychic ...value, does suggest that unemployed graduates are more likely to enlist, all other things equal, the higher their previous wage rate. The previous

The 2012 Long-Term Budget Outlook

DTIC Science & Technology

2012-06-01

cuts or tax increases would give families, businesses , and state and local governments little time to plan and adjust, and would require more... busi - nesses, and state and local governments little time to plan and adjust, and would require more sacrifices sooner from current older workers...path. By comparison, if productivity growth was 0.3 per- centage points lower every year than CBO had assumed, GDP in the 10th year would be 3

The Fast Follower: Coming Up Behind Development Leaders

DTIC Science & Technology

2015-06-01

DoD faces a shrinking defense industrial base and a more global tech marketplace and competes with the rise of consumer electronics that have short...to others and positions itself to rapidly exploit the newly discovered technical knowledge by quickly applying that knowledge to the unique needs of...technical aware- ness, organized for speed in innovation and has an intimate knowledge of its customer. From its vantage point on the first mover’s

Geology of a Stable Intraplate Region: The Cape Verde/Canary Basin,

DTIC Science & Technology

1982-03-01

reflection records indicate a possible Eocene age up- lifting. Extensive island volcanism and sill and dike emplacement occurred during Miocene. Many abyssal...hills and small scale faults are related to this Miocene tectonic phase. Island volcanism has a con- tinuing influence on the sedimentary sections. The...Plate is capable of generating zones of weak- nesses. These weakness zones could be expected to localize island volcanism , create north/south-trending

The American Experience with Pacification in Vietnam. Volume 3: History of Pacification

DTIC Science & Technology

1972-03-01

South Vietnam (the plan- ned farm conmminities wherein refugees were settled, mostly in the trans -Bassac area, in 1955-56). After the failure of the...responsibility of General Nguyen Duc Thang, 20 the Mhinister for Revolutionary Development (Pacification). Thang had taken over management of pacification in...the government busi- ness ... and I will keep professional secrets." Under Nguyen Duc Thang, Vietnam’s pacification cadre took a lengthy oath which

Turning Words Into Action: Confronting Acquisition Challenges

DTIC Science & Technology

2016-08-01

interdependencies to programs with simple, severable components, open architectures , and more distributed participation.” Transitions between full­time and...companies would be out of business . Sure, the Air Force makes more than just smart­ phones, but most electronics companies offer many models and devices...continue to change their way of thinking. With a conscious and critical awareness of how we do busi­ ness, why we do business as we do, and most important

Major Design Drivers for LEO Space Surveillance in Europe and Solution Concepts

NASA Astrophysics Data System (ADS)

Krag, Holger; Flohrer, Tim; Klinkrad, Heiner

Europe is preparing for the development of an autonomous system for space situational aware-ness. One important segment of this new system will be dedicated to surveillance and tracking of space objects in Earth orbits. First concept and capability analysis studies have led to a draft system proposal. This proposal foresees, in a first deployment step, a groundbased system consisting of radar sensors and a network of optical telescopes. These sensors will be designed to have the capability of building up and maintaining a catalogue of space objects. A number of related services will be provided, including collision avoidance and the prediction of uncontrolled reentry events. Currently, the user requirements are consolidated, defining the different services, and the related accuracy and timeliness of the derived products. In this consolidation process parameters like the lower diameter limit above which catalogue coverage is to be achieved, the degree of population coverage in various orbital regions and the accuracy of the orbit data maintained in the catalogue are important design drivers for the selection of number and location of the sensors, and the definition of the required sensor performance. Further, the required minimum time for the detection of a manoeuvre, a newly launched object or a fragmentation event, significantly determines the required surveillance performance. In the requirement consolidation process the performance to be specified has to be based on a careful analysis which takes into account accuracy constraints of the services to be provided, the technical feasibility, complexity and costs. User requirements can thus not be defined with-out understanding the consequences they would pose on the system design. This paper will outline the design definition process for the surveillance and tracking segment of the European space situational awareness system. The paper will focus on the low-Earth orbits (LEO). It will present the core user requirements and the definition of the derived services. The de-sired performance parameters will be explained together with presenting their rationale and justification. This will be followed by an identification of the resulting major design drivers. The influence of these drivers on the system design will be analysed, including limiting object diameter, population coverage, orbit maintenance accuracy, and the minimum time to detect events like manoeuvres or breakups. The underlying simulation and verification concept will be explained. Finally, a first compilation of performance parameters for the surveillance and tracking segment will be presented and discussed.

Human Factors Engineering Bibliographic Series. Volume 5, 1967 Literature

DTIC Science & Technology

1976-03-01

8217aining progracus designed to In- crease arn strength. There were 26 subects In each group. those In the experimental group, static and dyl’sic... experimental design over more usual classical procedures are Swq* gested.a’ 32,258 Cohen. 1t.l. CONTINUOUS VERSUS Tti. VISUAL FEEDSAX INl PRISM... experimental study was :?arformeed to evaluate, singly &no In combination, the effective- ness of a is-hr. training progrm and a set of visual aids designed to

Piper-betle-shaped nano-S-catalyzed synthesis of 1-amidoalkyl-2-naphthols under solvent-free reaction condition: a greener "nanoparticle-catalyzed organic synthesis enhancement" approach.

PubMed

Das, Vijay K; Borah, Madhurjya; Thakur, Ashim J

2013-04-05

Nano-S prepared by an annealing process showed excellent catalytic activity for the synthesis of 1-amidoalkyl-2-naphthols under solvent-free reaction condition at 50 °C. The catalyst could be reused up to the fifth cycle without loss in its action. The green-ness of the present protocol was also measured using green metrics drawing its superiority.

A Model for Education and Training for a Crisis-Expectant Period.

DTIC Science & Technology

1980-10-31

an alternative method of dealing with nuclear disaster depends on the distribution of information as to the appropriateness of various behavior...question of what an individual should be able to do in response to a nuclear disaster , and what kind of instruction would enable individuals to carry...be dysfunctional in an emergency. (Perry, et al., 1980, p. 66) Civil defense is a low-salience issue, especially because the awesome- ness of a nuclear

Refrigerated Platelets for the Treatment of Acute Bleeding: A Review of the Literature and Reexamination of Current Standards

DTIC Science & Technology

2014-01-01

F. Pidcoke,* Philip C. Spinella,† Anand K. Ramasubramanian,‡ Geir Strandenes,§|| Tor Hervig,|| Paul M. Ness,¶ and Andrew P. Cap* * Blood Research...associated with improved clinical outcomes in acutely bleeding trauma patients (1Y9). Despite common beliefs to the contrary, PLTs are available in whole- blood ...circulation (10). Platelets participate in immunomodulation, maintenance and repair of vessel structures, and, their best-known function, clot forma

Cultural Resources Investigations at Redstone Arsenal, Madison County, Alabama. Volume I.

DTIC Science & Technology

1980-01-01

Parmalee and Klippel’s (1974) nutritional I study of freshwater shellfish further confirmed this point of view by demonstrating first that shellfish were...by no means a complete food from the standpoint of human nutrition , and second that they were 1 markedly lower in protein than other locally available...cultural complexity of the Late Archaic shellmound peoples as simply the by-product of the nutritional rich- ness of the shellfish. Instead, the

Optimizing Sensing: From Water to the Web

DTIC Science & Technology

2009-05-01

e.g., when applied to busi - ness practices, the Pareto Principle says that “80% of your sales come from 20% of your clients.” In water distribution...of this challenge included a realistic model of a real metropolitan area water distribution network (Figure 4(a)) with 12,527 nodes, as well as a...we learn a probabilistic model P (Y,XV) from training data collected by [37] from 20 users. This model encodes the statistical dependencies between

The Coming Decade: American Women and Human Resources Policies and Programs, 1979. Hearings before the Committee on Labor and Human Resources, United States Senate, Ninety-Sixth Congress, 1st Session, Part 2.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Subcommittee on Labor and Human Resources.

Proceedings are presented of hearings before the Senate Committee on Labor and Human Resources to examine the conditions and opportunities confronting American women in the workplace and how government policies and programs have aided or restricted women. Among those testifying were Clara Allen and Stanley Van Ness on employment, the plight of the…

Military Need for Research and Development of a Malaria Vaccine

DTIC Science & Technology

1983-06-03

Army in Vietnam, 1965-1970, p. 39. * 211bid., p. 35. * . 22Hume, Victories in Military Medicine, p. 160. 231 bid . 16,:24Experimental Malaria...duration of the ill- ness may last from 21 - 30 days. Once malaria is considered a possibility, the diagnosis is con- firmed by laboratory results...place of the anopheline is water containing green algae 24 growth.25 Draining and covering small breeding areas with earth and draining and dispersing

Use of New and Minority-Owned Architectural and Engineering Firms by Selected Army and Navy Activities.

DTIC Science & Technology

1981-10-30

we directed our review to the preselection and selection processes for direct A/E awards,.not awards made under the Small Business Administration’s 8...policy of the United States that small busi - ness concerns and small business concerns owned and controlled by socially and economically disadvantaged...contracts exceeding $10,000 must contain the above state- ment. The Small Business Administration has defined small business concerns for A/E services

Revised Point of Departure Design Options for Nuclear Thermal Propulsion

NASA Technical Reports Server (NTRS)

Fittje, James E.; Schnitzler, Bruce G.; Borowoski, Stanley

2015-01-01

Four Revised Point of Departure NTR Engines were Designed and Analyzed using MCNP and NESS. All Four Engines Have Thermodynamically Closed Cycles at Nominal Chamber Pressures. 111 kilonewton (25 kip-force) Cermet Design Required Dedicated Heater Elements to Close the Cycle. Cermet Based Designs had Slightly Higher TW Ratios, but Required Substantially More U-235. NERVA Derived Criticality Limited Engine Could Operate at Lower Power and Thrust Levels Compared to the Criticality Limited Cermet Design.

Detection of U Sco in X-rays

NASA Astrophysics Data System (ADS)

Schlegel, Eric M.; Schaefer, Brad; Pagnotta, Ashley; Page, Kim; Osborne, Julian; Drake, Jeremy; Orio, Marina; Takei, Dai; Kuulkers, Erik; Ness, Jan-Uwe

2010-02-01

Eric M. Schlegel (UT-San Antonio); Brad Schaefer and Ashley Pagnotta (LSU); Kim Page and Julian Osborne (Leicester); Jeremy Drake (SAO); Marina Orio (Wisconsin), Dai Takei (Rikkyo Univ.), and Erik Kuulkers and Jan-Uwe Ness (ESA/ESAC), representing a large collaboration, report that U Sco has been detected in the X-ray band using the Swift satellite following the optical outburst discovery at V=8.05 on 2010 January 28.4743 (www.aavso.org/publications/alerts/alert415.shtml).

ONRASIA Scientific Information Bulletin, Volume 17, Number 2, April/June 1992

DTIC Science & Technology

1992-06-01

studying the role of overcomplete- Tel: +81-422-59-4201 seminar on wavelets was chosen to be ness properties and their applications Fax: +81-422-59-3393...technologies, explore interactive environment for man- to emulate various types of cache proto- applications, and study how theycan be machine interface...cols. The Keio professors specifically integrated. Flexible integration is seen want to study the kind of logic simula- as an important goal in order for

Pineal-Induced Depression of Free Thyroxine in Syrian Hamsters

DTIC Science & Technology

1985-01-01

activation by blind- ness in Syrian hamsters, can influence free 14 concentration. MATERIALS AND METHODS Male golden hamsters, Mesocricetus auratus...considered that the changes in T4 passively result from pineal- induced hypogonadism and the possible resultant effects on T4 serum bind- ing proteins...the presence of pineal-induced hypogonadism and that, like T4 and FT41, -• ’. 328 Vaughan and Pruitt TESrE S PROSTATE 0.6 80- 20 gn Mgm ,... =_ 9 Mg_

External versus Intuitive Reasoning: The Conjunction Fallacy in Probability Judgment.

DTIC Science & Technology

1983-06-01

tions. Linda is a teacher in elementary school . Linda works in a bookstore and takes Yoga classes. Linda is active in the feminist movement. (F) Linda...sophisticated group consisted of PhD students in the decision science program of the Stanford Busi- ness School , all with several advanced courses in... mind by seemingly incon- sequential cues. There is a contrast worthy of note between the effectiveness of exten- sional cues in the health-survey

Positioning Animal Welfare in the One Health Concept through Evaluation of an Animal Welfare Center in Skopje, Macedonia.

PubMed

Radeski, Miroslav; O'Shea, Helen; De Meneghi, Daniele; Ilieski, Vlatko

2017-01-01

The Animal Welfare Center (AWC) in Macedonia was established in 2009. The objectives of the center are animal welfare (AW) education, research, raising public awareness of AW, and increasing cooperation between the stakeholders. One Health (OH) was not the major focus of the AWC work initially, but, rather, a focus that evolved recently. The objective of this study was to evaluate the AWC from the OH perspective as an example case for positioning the AW within the overall OH concept. Three types of evaluation were performed: (1) assessment of OH-ness, by quantitative measurement of the operational and infrastructural aspects of the AWC; (2) impact evaluation, by conducting quantitative surveys on stakeholders and students; and (3) transdisciplinary evaluation, using semi-quantitative evaluation of the links of cooperation between the AWC and the stakeholders in society by the custom designed CACA (Cooperation, Activities, Communication, and Agreement) scoring system. Results for the OH-ness of the AWC showed relatively high scores for OH thinking, planning and working and middle scores for OH learning and sharing dimensions, i.e., dominance of the operational over infrastructural aspects of the AWC. The impact evaluation of the AWC shows that familiarity with the OH concept among stakeholders was low (44% of the respondents). However, there was a commonality among stakeholder's interest about AW and OH. According to the stakeholders' and students' opinions, the influence of AW on Animal, Environmental, and Human Health is relatively high (in the upper third of the 1-10 scale). The transdisciplinary evaluation of the AWC indicated the presence of transdisciplinarity work by the AWC, with a higher focus on the Universities and Research Institutions and some governmental institutions, and less linked with the Non-Governmental Organizations and Professional Associations (Chambers), e.g., the Veterinary Chamber in Macedonia. The evaluations conducted indicated that the AWC's work is closely dedicated to improving animal, environmental, and human health and has a considerable OH role among the stakeholders in the society. This study describes the significant role and importance that AW has in OH.

Towards an open grapevine information system

PubMed Central

Adam-Blondon, A-F; Alaux, M; Pommier, C; Cantu, D; Cheng, Z-M; Cramer, GR; Davies, C; Delrot, S; Deluc, L; Di Gaspero, G; Grimplet, J; Fennell, A; Londo, JP; Kersey, P; Mattivi, F; Naithani, S; Neveu, P; Nikolski, M; Pezzotti, M; Reisch, BI; Töpfer, R; Vivier, MA; Ware, D; Quesneville, H

2016-01-01

Viticulture, like other fields of agriculture, is currently facing important challenges that will be addressed only through sustained, dedicated and coordinated research. Although the methods used in biology have evolved tremendously in recent years and now involve the routine production of large data sets of varied nature, in many domains of study, including grapevine research, there is a need to improve the findability, accessibility, interoperability and reusability (FAIR-ness) of these data. Considering the heterogeneous nature of the data produced, the transnational nature of the scientific community and the experience gained elsewhere, we have formed an open working group, in the framework of the International Grapevine Genome Program (www.vitaceae.org), to construct a coordinated federation of information systems holding grapevine data distributed around the world, providing an integrated set of interfaces supporting advanced data modeling, rich semantic integration and the next generation of data mining tools. To achieve this goal, it will be critical to develop, implement and adopt appropriate standards for data annotation and formatting. The development of this system, the GrapeIS, linking genotypes to phenotypes, and scientific research to agronomical and oeneological data, should provide new insights into grape biology, and allow the development of new varieties to meet the challenges of biotic and abiotic stress, environmental change, and consumer demand. PMID:27917288

Losing the Dark: A Planetarium PSA about Light Pollution

NASA Astrophysics Data System (ADS)

Petersen, Carolyn Collins; Walker, Constance

2015-03-01

Losing the Dark is a six-minute PSA video created for fulldome theaters by Loch Ness Productions, the International Dark Sky Association Education Committee headed by Dr. Constance Walker of the National Optical Astronomy Observatories, Dome3, Adler Planetarium, and Babak Tafreshi (The World at Night). It explains light pollution, its effects, and ways to implement ``wise lighting`` practices to mitigate light pollution. The show is also made in flat-screen HD format for classical planetariums, non-dome theaters, and for presentatons by IDA speakers.

A Pronoun Analysis of Couples' Support Transactions.

PubMed

Hinnekens, Céline; Lemmens, Gilbert; Vanhee, Gaëlle; Verhofstadt, Lesley

2016-01-01

The present study collected data about couples' level of relationship quality and their usage of pronouns that express we-ness or separateness in the context of support interactions. The sample consisted of 48 couples in a long-term relationship who provided questionnaire data and participated in two videotaped social support interaction tasks. Couples' videotaped interactions were subsequently coded for the number of personal pronouns-we-words (e.g., we, ours, ourselves) versus you and me-words (e.g., me, mine, you, yours)-used by both partners.

The Effects of Total Sleep Deprivation and Recovery Sleep on Cognitive Performance and Brain Function

DTIC Science & Technology

2007-08-01

education : 15.3 ± 1.6) free of medical and psychiatric disor- ders participated in this study after providing written informed consent. All subjects... education 515.2 61.5 years). The study was approved by the local Institutional Review Board (the UCSD Human Research Protection Program), and it was...Stricker et al., 2006). The authors acknowledge the support of the VA VISN 22 Mental Ill- ness Research Education and Clinical Center, the US

Final Environmental Impact Statement (FEIS)/Final Environmental Impact Report (FEIR). Otis Air National Guard Base, Wastewater Treatment Facility

DTIC Science & Technology

1990-06-01

and G.E. Ness, 1982, Survival of Vibrio cholerae and Escherichia coli in Estuarine Water and Sediments, Applied and Environmental Microbiology, 43...and publications in areas of water and wastewater treatment. David Tomasko, Ph.D., 1985. University of New Mexico . Staff Hydrogeologist. Research...Reserve in California. We are working on EIS’s for the U.S. Air Force Base Closings in realignment in California, New Mexico and Washington, and a very

When There is Tumult - The Ohio Army National Guard and Civil Disturbance Control, 1965 - 1970

DTIC Science & Technology

1982-03-15

experi- nced 36 alerts for civil disturbances between 1965 and 1970 Fn almost all cases in which troops were committed to the r streets, they halted...constitution is an instructive case study in the appropriateness and effective- ness of military organizations in executing the laws in a democracy. 1 2 Three...time of state emergency and on the other to be prepared to become part of the active army upon the order of the President. The latter mission has

Cryptozoology Society

NASA Astrophysics Data System (ADS)

Richman, Barbara T.

Reports of Loch Ness monsters, Bigfoot, and the Yeti spring u p from time to time, sparking scientific controversy about the veracity of these observations. Now an organization has been established to help cull, analyze, and disseminate information on the alleged creatures. The International Society of Cryptozoology, formed at a January meeting at the U.S. National Museum of Natural History of the Smithsonian Institution, will serve as the focal point for the investigation, analysis, publication, and discussion of animals of unexpected form or size or of unexpected occurrences in time or space.

A Software Engineering Environment for the Navy.

DTIC Science & Technology

1982-03-31

Engineering Pr.cess . - 55 ?art II: Description of A Software Engineering Env.Lonnmeut 1. Data Base ........................................ 7 -3 L.I...Methodology to Tool 1-54 2.2.2.2-6 Flow of Management: Activity to Methodology to Tool 21- 55 2.2.2.2-7 Pipelining for Activity-Specific Tools 11-56 A.1.1-1 A...testing techniques. 2.2. 2 Methodciogies and Tools: Correctness Analysis Pai e T- 4Metboioioo ies aews - Pev2.ews Jeicrmine the in ernai ’ Qolc .. ness and

Fix-Forward: A Comparison of the Army’s Requirements and Capabilities for Forward Support Maintenance,

DTIC Science & Technology

1983-04-01

tolerances or spaci - able assets diagnostic/fault ness float fications isolation devices Operation of cannibalL- zation point Why Sustain materiel...with diagnostic software based on "fault tree " representation of the M65 ThS) to bridge the gap in diagnostics capability was demonstrated in 1980 and... identification friend or foe) which has much lower reliability than TSQ-73 peculiar hardware). Thus, as in other examples, reported readiness does not reflect

Clinical Evaluation of an Acrylic Pontic ’Adhesively’ Bonded to Uncut Abutment Teeth: 18 Month Results

DTIC Science & Technology

1974-12-23

of pumice in a rotating rubber cup and rinsed. The teeth were isolated with gauze, etched for two minutes with a gel type ...indefinitely. The advantages of oral tissue compatability, ease of con- struction and superior esthetics in - herent in this prosthesis were offset to a...H.S., Heifetz, S.B. and McCune, R.J. The effective- ness of an adhesive sealant in preventing occlusal caries: Findings after two years in

USAF Security Police Officer Leadership: Effectiveness, Agreement, and the Effects of Education and Experience

DTIC Science & Technology

1984-01-01

of the leadership styles and effectiveness of the security police officers studied. General Research Questions In exploring the relationship between...to do a task; B. Psycholo&c Maturity is the willins- 26 ness or motivation to do the job. 16. Four Specific Leadership Styles : A. A-Telling Style is...background, (1973) knowledge, and experience fac- tors. Vroom25 Leaders can be taught to en- • (1976) large their leadership styles and to match the

Nozzle Modifications for High-Reynolds-Number Quiet Flow in the Boeing/AFOSR Mach-6 Quiet Tunnel

DTIC Science & Technology

2006-12-01

n (% ) y = 0.0 cm y ...results of turbulent bursts. 49 60 70 80 90 100 0 0.02 0.04 0.06 0.08 0.1 Contraction pressure (psia) P ito t p re ss ur e rm s/ m ea n (% ) y ...rough- ness height T Temperature t time y radial location ( y = 0 along centerline) z axial location (z = 0 at throat and 2.590 m at end of Section 8)

Solid State Research, 1980:3.

DTIC Science & Technology

1980-08-15

wafers. The amount of overgrowth is dependent on the orientation of the silicon substrate and the thick- ness of the SiO 2 layer. V. ANALOG DEVICE...Moulton XI Intl. Quantum Electronics Metal-Doped Lasers A. Mooradian Conference, Boston, Z3-26 June 1980 5Z45 Temperature- Dependent Spectral D.J...High Tempera- C. 0. Bozler 24-27 June 1980 ture Anneal 5327 Growth-Temperature Dependence Z. L. Liau of LPE GaInAsP/lnP Lattice J. J. Hsieh Mismatch

Department of Defense Manpower Requirements Report for FY 1992

DTIC Science & Technology

1991-02-01

primary readi- ness inhibitor . To address this problem, the ARNG is involved in an effort to improve MOSQ through command emphasis and increased...D r-Oec o4- No NI aO OO Nln c CNI O ON0 m 0 cs00 ONCC% 00 0 0ON00000 -4 C (D n O LnO’ n 0% N 4 01 0 0 0 000 N% CYI0N a -T0 0%i l 0m40 0 1 C14 0 14 0

The Russian Military Today and Tomorrow: Essays in Memory of Mary Fitzgerald

DTIC Science & Technology

2010-07-01

profoundly original works of thinkers like Marshal Nikolai Og- arkov (1917-94), who was both Chief of the Soviet General Staff (1977-84) and an...unending informa- tion war has been supplemented by original thinking regarding the nature of what such a war might look like and how it might be...Russian defense reformers are now striving to overcome. The bold- ness and originality of Russian thinking about IW, from which we might do well to

Development of Silicone Rubbers for Use at Temperatures Down to -100 deg F

DTIC Science & Technology

1950-05-01

The properties of the cured stocks vary greatly, the tensile strength range being about ten-fold. The effective - ness of the pigments does not...the pigments (such as degassing at 1000°C. and 0.0001 .Tim. Hg, coating with a silicone film, etc.) has little effect on the results, leads to a...charges on the pigments and qn the gum. £ f The effect of variable volume loading has been determined for some of the most promising materials. Stocks

Gaze distribution analysis and saliency prediction across age groups.

PubMed

Krishna, Onkar; Helo, Andrea; Rämä, Pia; Aizawa, Kiyoharu

2018-01-01

Knowledge of the human visual system helps to develop better computational models of visual attention. State-of-the-art models have been developed to mimic the visual attention system of young adults that, however, largely ignore the variations that occur with age. In this paper, we investigated how visual scene processing changes with age and we propose an age-adapted framework that helps to develop a computational model that can predict saliency across different age groups. Our analysis uncovers how the explorativeness of an observer varies with age, how well saliency maps of an age group agree with fixation points of observers from the same or different age groups, and how age influences the center bias tendency. We analyzed the eye movement behavior of 82 observers belonging to four age groups while they explored visual scenes. Explorative- ness was quantified in terms of the entropy of a saliency map, and area under the curve (AUC) metrics was used to quantify the agreement analysis and the center bias tendency. Analysis results were used to develop age adapted saliency models. Our results suggest that the proposed age-adapted saliency model outperforms existing saliency models in predicting the regions of interest across age groups.

Abstracts of the 15th Annual Meeting of the Israel Society for Neuroscience Eilat, Israel, December 3–5, 2006

PubMed Central

2007-01-01

The Israel Society for Neuroscience (ISFN) was founded in 1993 by a group of Israeli leading scientists conducting research in the area of neurobiology. The primary goal of the society was to promote and disseminate the knowledge and understanding acquired by its members, and to strengthen interactions between them. Since then, the society holds its annual meeting every year in Eilat during the month of December. At these annual meetings the senior Israeli neurobiologists, their teams, and their graduate students, as well as foreign scientists and students, present their recent research findings in platform and poster presentations. The meeting also offers the opportunity for the researchers to exchange information with each other, often leading to the initiation of collaborative studies. Both the number of members of the society and of those participating in the annual meeting is constantly increasing, and it is anticipated that this year about 600 scientists will convene at the Princess Hotel in Eilat, Israel. Further information concerning the Israel Society for Neuroscience can be found at http://www.isfn.org.il. Committee: Zvi Wollberg (President) Tel Aviv University Edi Barkai University of Haifa Etti Grauer Israel Institute for Biological Research, Ness Ziona Yoram Rami Grossman Ben Gurion University of the Negev Yoel Yaari Hebrew University of Jerusalem Gal Yadid Bar-Ilan University Shlomo Rotshenker (President Elect) Hebrew University of Jerusalem Ettie Grauer (Treasurer) Israel Institute for Biological Research, Ness Ziona Michal Gilady (Administrator) Rishon Le Zion

Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates

PubMed Central

Pasquinelli, Amy E.; Powers, Maureen A.; Lund, Elsebet; Forbes, Douglass; Dahlberg, James E.

1997-01-01

Leucine-rich nuclear export signals (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shuttling proteins and RNAs. The export of messenger RNA in vertebrates was, however, thought to occur by a different pathway, because inhibition by injection of a synthetic Rev NES conjugate could not be demonstrated. Here we find that peptide conjugates composed of the NES of either protein kinase A inhibitor protein (PKI) or the HIV-1 Rev protein, when coupled to human serum albumin, are potent inhibitors of mRNA and small nuclear RNA export. These results provide direct evidence that mRNA export in vertebrates depends on interactions between an NES and its cognate NES receptors. PKI NES conjugates are significantly more efficient at inhibiting RNA export than are REV NES conjugates, indicating that different NESs may have different abilities to promote protein and RNA export. Surprisingly, an expected control conjugate containing the mutant Rev NES sequence M10 strongly inhibited the export of intronless dihydrofolate reductase mRNA. Nuclear injection of NES peptide conjugates led to mislocalization to the nucleus of 10–20% of the cytoplasmic Ran GTPase-binding protein (RanBP1) indicating that RanBP1 shuttles between the nucleus and the cytoplasm via an NES pathway. These results demonstrate that in vertebrates the export of mRNA, like that of small nuclear RNA, 5S rRNA, and transport factors such as RanBP1, employs NES-mediated molecular machinery. PMID:9405623

Nmd3p Is a Crm1p-Dependent Adapter Protein for Nuclear Export of the Large Ribosomal Subunit

PubMed Central

Ho, Jennifer Hei-Ngam; Kallstrom, George; Johnson, Arlen W.

2000-01-01

In eukaryotic cells, nuclear export of nascent ribosomal subunits through the nuclear pore complex depends on the small GTPase Ran. However, neither the nuclear export signals (NESs) for the ribosomal subunits nor the receptor proteins, which recognize the NESs and mediate export of the subunits, have been identified. We showed previously that Nmd3p is an essential protein from yeast that is required for a late step in biogenesis of the large (60S) ribosomal subunit. Here, we show that Nmd3p shuttles and that deletion of the NES from Nmd3p leads to nuclear accumulation of the mutant protein, inhibition of the 60S subunit biogenesis, and inhibition of the nuclear export of 60S subunits. Moreover, the 60S subunits that accumulate in the nucleus can be coimmunoprecipitated with the NES-deficient Nmd3p. 60S subunit biogenesis and export of truncated Nmd3p were restored by the addition of an exogenous NES. To identify the export receptor for Nmd3p we show that Nmd3p shuttling and 60S export is blocked by the Crm1p-specific inhibitor leptomycin B. These results identify Crm1p as the receptor for Nmd3p export. Thus, export of the 60S subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway. PMID:11086007

An anisotropic elastoplasticity model implemented in FLAG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buechler, Miles Allen; Canfield, Thomas R.

2017-10-12

Many metals, including Tantalum and Zirconium, exhibit anisotropic elastoplastic behavior at the single crystal level, and if components are manufactured from these metals through forming processes the polycrystal (component) may also exhibit anisotropic elastoplastic behavior. This is because the forming can induce a preferential orientation of the crystals in the polycrystal. One example is a rolled plate of Uranium where the sti /strong orientation of the crystal (c-axis) tends to align itself perpendicular to the rolling direction. If loads are applied to this plate in di erent orientations the sti ness as well as the ow strength of the materialmore » will be greater in the through thickness direction than in other directions. To better accommodate simulations of such materials, an anisotropic elastoplasticity model has been implemented in FLAG. The model includes an anisotropic elastic stress model as well as an anisotropic plasticity model. The model could represent single crystals of any symmetry, though it should not be confused with a high- delity crystal plasticity model with multiple slip planes and evolutions. The model is most appropriate for homogenized polycrystalline materials. Elastic rotation of the material due to deformation is captured, so the anisotropic models are appropriate for arbitrary large rotations, but currently they do not account for signi cant change in material texture beyond the elastic rotation of the entire polycrystal.« less

Dairy and nondairy beverage consumption for childhood atopic eczema: what health advice to give?

PubMed

Hon, K L; Tsang, Y C; Poon, T C W; Pong, N H H; Luk, N M; Leung, T N H; Chow, C M; Leung, T F

2016-03-01

Many parents of children with atopic eczema (AE) practise empirical dietary avoidance and supplementation, and seek healthcare advice on whether consumption of dairy and nondairy beverages may be beneficial or detrimental for this condition. We investigated if frequency of consumption of beverages was associated with disease severity and quality of life (QoL). Parent-reported frequency of drinks and beverages were recorded in consecutive children with AE, and disease severity (Nottingham Eczema Severity Score; NESS), QoL (Children's Dermatology Life Quality Index; CDLQI), skin hydration (SH), transepidermal water loss (TEWL), blood pressure (BP), resting heart rate (RHR) and body mass index (BMI) were evaluated. AE was associated with worse QoL than miscellaneous non-AE skin diseases (P < 0.001). Compared with children without AE, there was a trend for children with AE to drink less milk (P = 0.06) and more miscellaneous beverages (such as Chinese herbal tea and soymilk; P = 0.03). In children with AE, NESS correlated with CDLQI (ρ = 0.66, P < 0.001) and reduced SH (ρ = -0.32, P < 0.001), whereas CDLQI correlated with a higher RHR (ρ = 0.25, P < 0.01). Multiple logistic regression showed that male sex (OR = 0.44, 95% CI 0.20-0.97; P = 0.04) and drinking fresh milk (OR = 0.42, 95% CI 0.20-0.93; P = 0.03) were independent factors associated with less severe disease. Moderate to severe impairment of CDLQI was associated with NESS (OR = 1.48, 95% CI 1.28-1.71; P < 0.001) and RHR (OR = 1.05, 95% CI 1.02-1.08; P < 0.01) but not with reported habits of beverage consumption. Concerning cardiovascular health in AE, frequency of formula milk consumption was associated with RHR (ρ = 0.17, P = 0.04), and soft drink consumption was associated with higher systolic blood pressure (SBP) (ρ = 0.18, P = 0.04). This study provides evidence for parental/patient guidance. Children with AE who reported more fresh milk consumption had less severe disease. There was no correlation between consumption of nondairy beverages with disease severity or QoL, but frequency of soft drink consumption correlated with SBP. With these results being supported by a literature review, it is reasonable to advise parents that fresh milk can be consumed by unsensitized children with AE. Soft drinks and other beverages should not be consumed in excess for optimal cardiovascular health and for other health reasons. © 2015 British Association of Dermatologists.

Energy consumption and entropy production in a stochastic formulation of BCM learning

NASA Astrophysics Data System (ADS)

de Oliveira, L. R.; Castellani, G.; Turchetti, G.

2013-12-01

Biochemical processes in living cells are open systems, therefore they exchange materials with their environment and they consume chemical energy. These processes are molecular-based and for that reason the role of fluctuations can not be ignored and the stochastic description is the most appropriate one. The chemical master equation describes in exact way the probabilistic dynamics of a given discrete set of states and helps us to understand and clarify the differences between closed and open systems. A closed system is related to a condition of detailed balance (DB), i.e. an equilibrium state. After a sufficiently long period, an open system will reach a non-equilibrium steady state (NESS) that is sustained by a flux of external energy. We demonstrate that two implementations of the BCM learning rule (BCM82) and (BCM92) are, respectively, always in DB, and never in DB. We define a one parameter parametrization of the BCM learning rule that interpolates between these two extremes. We compute thermodynamical quantities such as internal energy, free energy (both Helmholtz and Gibbs) and entropy. The entropy variation in the case of open systems (i.e. when DB does not hold) can be divided into internal entropy production and entropy exchanged with surroundings. We show how the entropy variation can be used to find the optimal value (corresponding to increased robustness and stability) for the parameter used in the BCM parametrization. Finally, we use the calculation of the work to drive the system from an initial state to the steady state as the parameter of the plasticity of the system.

Storm-rhine -simulation Tool For River Management

NASA Astrophysics Data System (ADS)

Heun, J. C.; Schotanus, T. D.; de Groen, M. M.; Werner, M.

The Simulation Tool for River Management (STORM), based on the River Rhine case, aims to provide insight into river and floodplain management, by (1) raising aware- ness of river functions, (2) exploring alternative strategies, (3) showing the links be- tween natural processes, spatial planning, engineering interventions, river functions and stakeholder interests, (4) facilitating the debate between different policy makers and stakeholders from across the basin and (5) enhancing co-operation and mutual un- derstanding. The simulation game is built around the new concepts of SRoom for the & cedil;RiverT, Flood Retention Areas, Resurrection of former River Channels and SLiving & cedil;with the FloodsT. The Game focuses on the Lower and Middle Rhine from the Dutch Delta to Maxau in Germany. Influences from outside the area are included as scenarios for boundary conditions. The heart of the tool is the hydraulic module, which calcu- lates representative high- and low water-levels for different hydrological scenarios and influenced by river engineering measures and physical planning in the floodplains. The water levels are translated in flood risks, navigation potential, nature development and land use opportunities in the floodplain. Players of the Game represent the institutions: National, Regional, Municipal Government and Interest Organisations, with interests in flood protection, navigation, agriculture, urban expansion, mining and nature. Play- ers take typical river and floodplain engineering, physical planning and administrative measures to pursue their interests in specific river functions. The players are linked by institutional arrangements and budgetary constraints. The game particularly aims at middle and higher level staff of local and regional government, water boards and members of interest groups from across the basin, who deal with particular stretches or functions of the river but who need (1) to be better aware of the integrated whole, (2) to understand the interests and considerations of others and (3) to experience the mu- tual benefits of co-operation. There is potential for using the game as one of the tools in support of interactive formulation of policy and participatory decision-making in actual plans.

Trombo flutuante em veia femoral

PubMed Central

Bertanha, Matheus; Pimenta, Rafael Elias Farres; Brandão, Gustavo Muçouçah Sampaio; Sobreira, Marcone Lima; Moura, Regina; Jaldin, Rodrigo Gibin; de Camargo, Paula Angeleli Bueno; Yoshida, Winston Bonetti

2017-01-01

Resumo O trombo venoso flutuante em veia femoral é um tipo de trombo com alto potencial de embolização pulmonar. Entretanto, ainda é controversa a conduta mais apropriada nesses casos. Tratamentos clínicos com anticoagulantes ou fibrinolíticos e trombectomias abertas ou por meio de dispositivos endovasculares vêm sendo empregados ainda sem um critério de indicação bem definido. Apresentamos três casos clínicos de trombos flutuantes em veia femoral, de etiologias distintas, cujos tratamentos e respectivas evoluções serão discutidos. PMID:29930666

A Pronoun Analysis of Couples’ Support Transactions

PubMed Central

Hinnekens, Céline; Lemmens, Gilbert; Vanhee, Gaëlle; Verhofstadt, Lesley

2016-01-01

The present study collected data about couples’ level of relationship quality and their usage of pronouns that express we-ness or separateness in the context of support interactions. The sample consisted of 48 couples in a long-term relationship who provided questionnaire data and participated in two videotaped social support interaction tasks. Couples’ videotaped interactions were subsequently coded for the number of personal pronouns—we-words (e.g., we, ours, ourselves) versus you and me-words (e.g., me, mine, you, yours)—used by both partners. PMID:26869976

Comparative Analysis of Angiogenic Gene Expression in Normal and Impaired Wound Healing in Diabetic Mice: Effects of Extracorporeal Shock Wave Therapy

DTIC Science & Technology

2010-01-01

vivo. Circulation 110(19): 3055-3061 19. Stojadinovic A, Elster EA, Anam K et al (2008) Angiogenic response to extracorporeal shock wave treatment in...healing in diabetic mice: effects of extracorporeal shock wave therapy Stephen R. Zins • Mihret F. A mare • Douglas K. Tadaki • Eric. A. Elster... extracorporeal shock wave therapy (ESWT), which has been demonstrated to improve wound healing. Full-thick- ness skin from the dorsal surface of "nonnal" (BALB

Joint Project Manager (JPM) Chemical Biological Individual and Collective Protection Industry Day

DTIC Science & Technology

2008-07-22

ANSWER: The SBA operates the Office of Women’s B i O hi Th OWBO t thus ness wners p. e promo es e growth of women owned businesses through programs...TIC prioritization focused on a h i i k t f h tcompre ens ve r s managemen o w a we do not know: Absolute global production levels Absolute global...Modeling (For operational analyses) 2. Breakthrough Levels 3 D t ti A h. e ec on pproac es Multiple species may be present 4. Chemical Class Analysis

Algorithms for the Equilibration of Matrices and Their Application to Limited-Memory Quasi-Newton Methods

DTIC Science & Technology

2010-05-01

irreducible, by the Perron - Frobenius theorem (see, for example, Theorem 8.4.4 in [28]), the eigenvalue 1 is simple. Next, the rank-one matrix Q has the...We refer to (2.1) as the scaling equation. Although algorithms must use A, existence and unique- ness theory need consider only the nonnegative matrix...B. If p = 1 and A is nonnegative , then A = B. We reserve the term binormalization for the case p = 2. We say A is scalable if there exists x > 0

The Body Composition Project: A Summary Report and Descriptive Data

DTIC Science & Technology

1986-12-01

abundance of muscle as opposed to excess fat . This issue was address- "-o ed inA epartment of Defense DirecLv-.% 3O8 .-- a-a -resu-lt -,A---4ronr % 11L I...state in terms of an individual’s relative body fat as estimated by-the sur .-f 4 s"nfolds. Shortly after implementation, the validity of the height...weight and body fat standards as -well as the appropriate- ness of the skinfold methodology was questioned. A study was designed to create a data base

Temper Brittleness and Its Relation to the Heat Treatment of Ordnance Materiel

DTIC Science & Technology

1945-06-20

obtained in such bainitic steels only when they are tempered A to relatively lor hardnesees (approximately 200 VM or 85,000 psi yield stren-X.th). g...iiuzn, and! nickel inCtease the tVenC-ency f or temp er brittle- ness to occur as well as its severity w-hen it does occuir. Steels of equal...these. elements also lower the impact pro-perties of the uneirnbrittleO. ste’el. in low and. medlwa alloy steels molybd~entiu is so effective in

Aerospace Structural Metals Handbook. Volume 5. Supplement XI. Nonferrous Alloys

DTIC Science & Technology

1978-12-01

4140 Sep 74 1204 fe-(0.3C)-l.8,Ni-0.8Cr-0.4Mo-0.07V...IN CIAD WITH! FOILS OF Ni-20Cr-4AI-1.251 OF V C.-• LLA C LADDIN ALLOY ~THICKiNESS ,002. .005, AND .01 INCH U.SING (SUBSTRATE SAE ALLOY FACE SHEEKTS...31, 87, D54 ’est 0 .15xU Bar Electron Beamn Welded In Similar S~cmOJDesrilbed Below ha letNcie AsWn ,elded IlHeat Treat (t,, resterngthen apao

A Least Cost Study for Book Procurement at the Naval Postgraduate School Library

DTIC Science & Technology

1990-06-01

NAVAL POSTGRADUATE SCHOOL Monterey, California S7GR W DTIC &ELECTF ~jj N30 1 991TAES 0)0 THESIS B A LEAST COST STUDY FOR BOOK PROCUREMENT AT THE...Monterey, California 93943-5000 Monterey, California 93943-5000 C’ ’. z - I l a-, -.~,:IV A LEAST COST STUDY FOR BOOK PROCUREMENT AT THE NAVAL...Cost Study . , A . O -’U] aL’,"- ) t’ ’’- The primary objective of this thesis is to perform a cost effective- ness analysis of the various purchasing

An Examination of the Reliability of the Organizational Assessment Package (OAP).

DTIC Science & Technology

1981-07-01

reactiv- ity or pretest sensitization (Bracht and Glass, 1968) may occur. In this case, the change from pretest to posttest can be caused just by the...content items. The blocks for supervisor’s code were left blank, work group code was coded as all ones , and each person’s seminar number was coded in...63 5 19 .91 .74 5 (Work Group Effective- ness) 822 19 .83 .42 7 17 .90 .57 7 (Job Related Sati sfacti on ) 823 16 .91 .84 2 18 .93 .87 2 (Job Related

Stratigraphy and Glacial-Marine Sediments of the Amerasian Basin, Central Arctic Ocean.

DTIC Science & Technology

1981-02-01

to light sello~ish-hrown silt v l: t te (unit I. ahme. Scale bar% art- I cn). /19 FL 216- 18 L-i prohaih1 ilects the thickncss pattern of unitI I...so~ 100011 I3 M, 560 2 Figure I S. Thick ness (of unit t in centimetres. All1 fractional % aluesl are Figure 18 . IDistrihoution oif the comhined...estimated date ofl occurrence (hased] on Age of Stratigraphic Units magnetic signature) for (fhe unconforntitv in core H. 2 18 is, (0.29 m. ’ %o

Nonequilibrium generalised Langevin equation for the calculation of heat transport properties in model 1D atomic chains coupled to two 3D thermal baths.

PubMed

Ness, H; Stella, L; Lorenz, C D; Kantorovich, L

2017-04-28

We use a generalised Langevin equation scheme to study the thermal transport of low dimensional systems. In this approach, the central classical region is connected to two realistic thermal baths kept at two different temperatures [H. Ness et al., Phys. Rev. B 93, 174303 (2016)]. We consider model Al systems, i.e., one-dimensional atomic chains connected to three-dimensional baths. The thermal transport properties are studied as a function of the chain length N and the temperature difference ΔT between the baths. We calculate the transport properties both in the linear response regime and in the non-linear regime. Two different laws are obtained for the linear conductance versus the length of the chains. For large temperatures (T≳500 K) and temperature differences (ΔT≳500 K), the chains, with N>18 atoms, present a diffusive transport regime with the presence of a temperature gradient across the system. For lower temperatures (T≲500 K) and temperature differences (ΔT≲400 K), a regime similar to the ballistic regime is observed. Such a ballistic-like regime is also obtained for shorter chains (N≤15). Our detailed analysis suggests that the behaviour at higher temperatures and temperature differences is mainly due to anharmonic effects within the long chains.

Turbopump Design and Analysis Approach for Nuclear Thermal Rockets

NASA Technical Reports Server (NTRS)

Chen, Shu-cheng S.; Veres, Joseph P.; Fittje, James E.

2006-01-01

A rocket propulsion system, whether it is a chemical rocket or a nuclear thermal rocket, is fairly complex in detail but rather simple in principle. Among all the interacting parts, three components stand out: they are pumps and turbines (turbopumps), and the thrust chamber. To obtain an understanding of the overall rocket propulsion system characteristics, one starts from analyzing the interactions among these three components. It is therefore of utmost importance to be able to satisfactorily characterize the turbopump, level by level, at all phases of a vehicle design cycle. Here at NASA Glenn Research Center, as the starting phase of a rocket engine design, specifically a Nuclear Thermal Rocket Engine design, we adopted the approach of using a high level system cycle analysis code (NESS) to obtain an initial analysis of the operational characteristics of a turbopump required in the propulsion system. A set of turbopump design codes (PumpDes and TurbDes) were then executed to obtain sizing and performance characteristics of the turbopump that were consistent with the mission requirements. A set of turbopump analyses codes (PUMPA and TURBA) were applied to obtain the full performance map for each of the turbopump components; a two dimensional layout of the turbopump based on these mean line analyses was also generated. Adequacy of the turbopump conceptual design will later be determined by further analyses and evaluation. In this paper, descriptions and discussions of the aforementioned approach are provided and future outlooks are discussed.

"Everyone just ate good food": 'Good food' in Islamabad, Pakistan.

PubMed

Hasnain, Saher

2018-08-01

In recent years, consumption of alternatively produced foods has increased in popularity in response to the deleterious effects of rapidly globalising and industrialised food systems. Concerns over food safety in relation to these changes may result from elevated levels of risk and changing perceptions associated with food production practices. This paper explores how the middle class residents of Islamabad, Pakistan, use the concept of 'good food' to reconnect themselves with nature, changing food systems, and traditional values. The paper also demonstrates how these ideas relate to those of organic, local, and traditional food consumption as currently used in more economically developed states in the Global North. Through research based on participant observation and semi-structured interviews, this paper illustrates that besides price and convenience, purity, freshness, association with specific places, and 'Pakistani-ness' were considered as the basis for making decisions about 'good food'. The results show that while individuals are aware of and have some access to imported organic and local food, they prefer using holistic and culturally informed concepts of 'good food' instead that reconnect them with food systems. I argue that through conceptualisations of 'good food', the urban middle class in Islamabad is reducing their disconnection and dis-embeddedness from nature, the food systems, and their social identities. The paper contributes to literature on food anxieties, reconnections in food geography, and 'good food' perceptions, with a focus on Pakistan. Copyright © 2018. Published by Elsevier Ltd.

Evaluation of the Nutraceutical and Cosmeceutical Potential of Two Cultivars of Rubus fruticosus L. under Different Cultivation Conditions.

PubMed

Papaioanou, Maria; Chronopoulou, Evangelia G; Ciobotari, Gheorghii; Efrose, Rodica C; Sfichi-Duke, Liliana; Chatzikonstantinou, Marianna; Pappa, Evangelia; Ganopoulos, Ioannis; Madesis, Panagiotis; Nianiou-Obeidat, Irini; Zeng, Taofen; Labrou, Nikolaos E

2017-01-01

The starting point for the development of new, functional products derived from Rubus fruticosus L. is to determine the optimal cultivation conditions that produce maximal yield of fruits containing desirable bioactive properties. Towards that goal, the effect of soil, soil/peat mixture and light intensity on the nutraceutical and cosmeceutical potential of two cultivars ('Thornfree' and 'Loch Ness') of Rubus fruticosus L. were evaluated. The assessment was carried out employing a range of methods for evaluating fruit properties associated with promoting good health such as total antioxidant capacity, secondary metabolites content (vitamin C, polyphenols, flavonoids and anthocyanins) and inhibition analysis of skin-regulating enzymes. 'Thornfree' cultivar produced fruits in all light conditions, while 'Loch Ness' did not produce fruits in low light conditions. The results showed that in Rubus fruticosus L. fruit, the chemical composition and bioactivity are strongly affected by both genetics factors and growing conditions. Extract from 'Thornfree' fruits obtained under low light and soil/peat conditions displayed superior properties such as high antioxidant capacity, high concentrations of phenolics, flavonoids and anthocyanins and high inhibitory potency towards the enzymes tyrosinase and elastase. This extract was used for the development of a topical skin care cream with excellent compatibility and stability. Our findings conclude that Rubus fruticosus L. cultivation may be efficiently and effectively manipulated through conventional cultivation techniques to produce promising bioactive ingredients with potential use in commercial cosmetics and pharmaceuticals. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The rupture and repair of the couple's communal body with prostate cancer.

PubMed

Fergus, Karen D

2011-06-01

Intimate partners' ability to adopt a "we" outlook in relation to cancer has consistently been associated with optimal adaptation for couples. This investigation adds to the growing body of literature on dyadic coping and resiliency in couples through an in-depth examination of five well-adjusted couples' experiences with prostate cancer. Of specific interest were (1) how the experience of prostate cancer affected the couple's unique intersubjective identity, and how in turn (2) the couple's identity and relationship culture influenced their adjustment to cancer. An ethnographic mode of inquiry was adopted. Marital partners were interviewed together on two separate occasions with the intention of having them deepen their conjoint reflexive processing of their relationship. During the interviews, couples were asked to reflect upon and articulate their sense of themselves as a couple, their experience of "we-ness" and shared identity, and the interaction between the illness and we-ness. Interviews were transcribed verbatim and analyzed using the grounded theory method. The grounded theory analysis yielded three main themes portraying the couples' experience of prostate cancer: (1) riding the vortex, (2) holding the communal body intact, and (3) invincibility and its underbelly. A more broad understanding to arise from this investigation was the notion of a "communal body" and that couples participated in a shared corporeality, to which each partner's identity and sense of self was intricately tied. It is concluded that the intersubjective embodiment displayed by couples in this study was instrumental to the "repair" of the communal body ruptured by prostate cancer. ©2011 APA

Identification of Novel Saccharomyces cerevisiae Proteins with Nuclear Export Activity: Cell Cycle-Regulated Transcription Factor Ace2p Shows Cell Cycle-Independent Nucleocytoplasmic Shuttling

PubMed Central

Jensen, Torben Heick; Neville, Megan; Rain, Jean Christophe; McCarthy, Terri; Legrain, Pierre; Rosbash, Michael

2000-01-01

Nuclear export of proteins containing leucine-rich nuclear export signals (NESs) is mediated by the NES receptor CRM1/Crm1p. We have carried out a yeast two-hybrid screen with Crm1p as a bait. The Crm1p-interacting clones were subscreened for nuclear export activity in a visual assay utilizing the Crm1p-inhibitor leptomycin B (LMB). This approach identified three Saccharomyces cerevisiae proteins not previously known to have nuclear export activity. These proteins are the 5′ RNA triphosphatase Ctl1p, the cell cycle-regulated transcription factor Ace2p, and a protein encoded by the previously uncharacterized open reading frame YDR499W. Mutagenesis analysis show that YDR499Wp contains an NES that conforms to the consensus sequence for leucine-rich NESs. Mutagenesis of Ctl1p and Ace2p were unable to identify specific NES residues. However, a 29-amino-acid region of Ace2p, rich in hydrophobic residues, contains nuclear export activity. Ace2p accumulates in the nucleus at the end of mitosis and activates early-G1-specific genes. We now provide evidence that Ace2p is nuclear not only in late M-early G1 but also during other stages of the cell cycle. This feature of Ace2p localization explains its ability to activate genes such as CUP1, which are not expressed in a cell cycle-dependent manner. PMID:11027275

The population of natural Earth satellites

NASA Astrophysics Data System (ADS)

Granvik, Mikael; Vaubaillon, Jeremie; Jedicke, Robert

2012-03-01

We have for the first time calculated the population characteristics of the Earth’s irregular natural satellites (NESs) that are temporarily captured from the near-Earth-object (NEO) population. The steady-state NES size-frequency and residence-time distributions were determined under the dynamical influence of all the massive bodies in the Solar System (but mainly the Sun, Earth, and Moon) for NEOs of negligible mass. To this end, we compute the NES capture probability from the NEO population as a function of the latter’s heliocentric orbital elements and combine those results with the current best estimates for the NEO size-frequency and orbital distribution. At any given time there should be at least one NES of 1-m diameter orbiting the Earth. The average temporarily-captured orbiter (TCO; an object that makes at least one revolution around the Earth in a co-rotating coordinate system) completes (2.88 ± 0.82) rev around the Earth during a capture event that lasts (286 ± 18) d. We find a small preference for capture events starting in either January or July. Our results are consistent with the single known natural TCO, 2006 RH120, a few-meter diameter object that was captured for about a year starting in June 2006. We estimate that about 0.1% of all meteors impacting the Earth were TCOs.

Vodcasting Space Weather

NASA Astrophysics Data System (ADS)

Collins Petersen, Carolyn; Erickson, P. J.; Needles, M.

2009-01-01

The topic of space weather is the subject of a series of vodcasts (video podcasts) produced by MIT Haystack Observatory (Westford, MA) and Loch Ness Productions (Groton, MA). This paper discusses the production and distribution of the series via Webcast, Youtube, and other avenues. It also presents preliminary evaluation of the effectiveness and outreach of the project through feedback from both formal and information education venues. The vodcast series is linked to the NASA Living With a Star Targeted Research and Technology project award "Multi-Instrument Investigation of Inner-Magnetospheric/Ionosphere Disturbances.” It is being carried out by Principal Investigator Dr. John Foster, under the auspices of NASA Grant # NNX06AB86G. The research involves using ionospheric total electron content (TEC) observations to study the location, extent, and duration of perturbations within stormtime ionospheric electric fields at mid- to low latitudes. It combines ground-based global positioning system (GPS) TEC data, incoherent scatter radar measurements of the mid-latitude ionospheric state, and DMSP satellite observations to characterize conditions which lead to severe low-latitude ionospheric perturbations. Each vodcast episode covers a certain aspect of space weather and the research program.

Treating without Seeing: Pain Management Practice in a Thai Context.

PubMed

Chatchumni, Manaporn; Namvongprom, Ampaporn; Eriksson, Henrik; Mazaheri, Monir

2016-01-01

Pain management is a core nursing function, and it plays a key role in postoperative care. It is important to understand the cultural context of nursing practices and how this affects effective pain management. The aim of this study was to describe the professional and cultural framework within which pain management is practiced on a Thai surgical ward. Spradley's ethnographic methodology was used. Data were collected through 98.5 hours of field observations and interviews at a surgical ward in Thailand. Three themes were constructed that describe the way Thai nurses practiced pain management: (i) complex communications system to address pain and to respond to it, (ii) the essence of Thai-ness, and (iii) a passive approach to pain management. The results indicate that, in the response to discomfort and pain, better pain management will result if there is a shift from functional to patient-centered care. The nursing culture needs to be further researched and discussed, in order to set priorities in line with the goals of national and international organizations for improving postoperative care and promoting patient comfort.

A high-throughput screening system targeting the nuclear export pathway via the third nuclear export signal of influenza A virus nucleoprotein.

PubMed

Kakisaka, Michinori; Mano, Takafumi; Aida, Yoko

2016-06-02

Two classes of antiviral drugs, M2 channel inhibitors and neuraminidase (NA) inhibitors, are currently approved for the treatment of influenza; however, the development of resistance against these agents limits their efficacy. Therefore, the identification of new targets and the development of new antiviral drugs against influenza are urgently needed. The third nuclear export signal (NES3) of nucleoprotein (NP) is the most important for viral replication among seven NESs encoded by four viral proteins, NP, M1, NS1, and NS2. NP-NES3 is critical for the nuclear export of NP, and targeting NP-NES3 is therefore a promising strategy that may lead to the development of antiviral drugs. However, a high-throughput screening (HTS) system to identify inhibitors of NP nuclear export has not been established. Here, we developed a novel HTS system to evaluate the inhibitory effects of compounds on the nuclear export pathway mediated by NP-NES3 using a MDCK cell line stably expressing NP-NES3 fused to a green fluorescent protein from aequorea coerulescens (AcGFP-NP-NES3) and a cell imaging analyzer. This HTS system was used to screen a 9600-compound library, leading to the identification of several hit compounds with inhibitory activity against the nuclear export of AcGFP-NP-NES3. The present HTS system provides a useful strategy for the identification of inhibitors targeting the nuclear export of NP via its NES3 sequence. Copyright © 2016. Published by Elsevier B.V.

Studies of the Nature of Wear

DTIC Science & Technology

1974-10-28

spheres. In another test, specimens of EN-8 ( SAE 1040) steel heat treated to a hard- ness of 36 R.C. were run under the same conditions as reported...pits evident in the test of the Armco 17-4 steel were found on these samples, This test indicated that the SAE -1040 steel is more pro.e to fatigue...MMHI .^MMMaate mm^^^t^ma^mm ■’-■■■-- ■■■ ■---’---■■ -■ fl g Q Ü :; i i A repeat of this test with SAE -1040 steel heat treated to a hardness of

On the mechanism of ray closure in comet tails

NASA Astrophysics Data System (ADS)

Ershkovich, A. I.

The folding phenomenon of comet tail rays is explained by means of an electric drift due to convectional electric fields. This mechanism results in an angular rate of closure which reduces to that obtained by Ness and Donn (1966) if the velocity profile across the tail is linear and the plasma conductivity is ideal. Observations of both the ray closure and the disconnection events point to the phenomenon of anomalous resistivity. Magnetic fields of about 30-40 gammas in the coma and of 10 gammas in the distant tail (at 1 AU) are estimated from the MHD momentum equation.

Agile Acceptance Test–Driven Development of Clinical Decision Support Advisories: Feasibility of Using Open Source Software

PubMed Central

Baldwin, Krystal L; Kannan, Vaishnavi; Flahaven, Emily L; Parks, Cassandra J; Ott, Jason M; Willett, Duwayne L

2018-01-01

Background Moving to electronic health records (EHRs) confers substantial benefits but risks unintended consequences. Modern EHRs consist of complex software code with extensive local configurability options, which can introduce defects. Defects in clinical decision support (CDS) tools are surprisingly common. Feasible approaches to prevent and detect defects in EHR configuration, including CDS tools, are needed. In complex software systems, use of test–driven development and automated regression testing promotes reliability. Test–driven development encourages modular, testable design and expanding regression test coverage. Automated regression test suites improve software quality, providing a “safety net” for future software modifications. Each automated acceptance test serves multiple purposes, as requirements (prior to build), acceptance testing (on completion of build), regression testing (once live), and “living” design documentation. Rapid-cycle development or “agile” methods are being successfully applied to CDS development. The agile practice of automated test–driven development is not widely adopted, perhaps because most EHR software code is vendor-developed. However, key CDS advisory configuration design decisions and rules stored in the EHR may prove amenable to automated testing as “executable requirements.” Objective We aimed to establish feasibility of acceptance test–driven development of clinical decision support advisories in a commonly used EHR, using an open source automated acceptance testing framework (FitNesse). Methods Acceptance tests were initially constructed as spreadsheet tables to facilitate clinical review. Each table specified one aspect of the CDS advisory’s expected behavior. Table contents were then imported into a test suite in FitNesse, which queried the EHR database to automate testing. Tests and corresponding CDS configuration were migrated together from the development environment to production, with tests becoming part of the production regression test suite. Results We used test–driven development to construct a new CDS tool advising Emergency Department nurses to perform a swallowing assessment prior to administering oral medication to a patient with suspected stroke. Test tables specified desired behavior for (1) applicable clinical settings, (2) triggering action, (3) rule logic, (4) user interface, and (5) system actions in response to user input. Automated test suite results for the “executable requirements” are shown prior to building the CDS alert, during build, and after successful build. Conclusions Automated acceptance test–driven development and continuous regression testing of CDS configuration in a commercial EHR proves feasible with open source software. Automated test–driven development offers one potential contribution to achieving high-reliability EHR configuration. Vetting acceptance tests with clinicians elicits their input on crucial configuration details early during initial CDS design and iteratively during rapid-cycle optimization. PMID:29653922

Agile Acceptance Test-Driven Development of Clinical Decision Support Advisories: Feasibility of Using Open Source Software.

PubMed

Basit, Mujeeb A; Baldwin, Krystal L; Kannan, Vaishnavi; Flahaven, Emily L; Parks, Cassandra J; Ott, Jason M; Willett, Duwayne L

2018-04-13

Moving to electronic health records (EHRs) confers substantial benefits but risks unintended consequences. Modern EHRs consist of complex software code with extensive local configurability options, which can introduce defects. Defects in clinical decision support (CDS) tools are surprisingly common. Feasible approaches to prevent and detect defects in EHR configuration, including CDS tools, are needed. In complex software systems, use of test-driven development and automated regression testing promotes reliability. Test-driven development encourages modular, testable design and expanding regression test coverage. Automated regression test suites improve software quality, providing a "safety net" for future software modifications. Each automated acceptance test serves multiple purposes, as requirements (prior to build), acceptance testing (on completion of build), regression testing (once live), and "living" design documentation. Rapid-cycle development or "agile" methods are being successfully applied to CDS development. The agile practice of automated test-driven development is not widely adopted, perhaps because most EHR software code is vendor-developed. However, key CDS advisory configuration design decisions and rules stored in the EHR may prove amenable to automated testing as "executable requirements." We aimed to establish feasibility of acceptance test-driven development of clinical decision support advisories in a commonly used EHR, using an open source automated acceptance testing framework (FitNesse). Acceptance tests were initially constructed as spreadsheet tables to facilitate clinical review. Each table specified one aspect of the CDS advisory's expected behavior. Table contents were then imported into a test suite in FitNesse, which queried the EHR database to automate testing. Tests and corresponding CDS configuration were migrated together from the development environment to production, with tests becoming part of the production regression test suite. We used test-driven development to construct a new CDS tool advising Emergency Department nurses to perform a swallowing assessment prior to administering oral medication to a patient with suspected stroke. Test tables specified desired behavior for (1) applicable clinical settings, (2) triggering action, (3) rule logic, (4) user interface, and (5) system actions in response to user input. Automated test suite results for the "executable requirements" are shown prior to building the CDS alert, during build, and after successful build. Automated acceptance test-driven development and continuous regression testing of CDS configuration in a commercial EHR proves feasible with open source software. Automated test-driven development offers one potential contribution to achieving high-reliability EHR configuration. Vetting acceptance tests with clinicians elicits their input on crucial configuration details early during initial CDS design and iteratively during rapid-cycle optimization. ©Mujeeb A Basit, Krystal L Baldwin, Vaishnavi Kannan, Emily L Flahaven, Cassandra J Parks, Jason M Ott, Duwayne L Willett. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 13.04.2018.

Brain imaging in normal kids: a community-based MRI study in Malawian children.

PubMed

Potchen, M J; Kampondeni, S D; Mallewa, M; Taylor, T E; Birbeck, G L

2013-04-01

To collect normative MRI data for effective clinical and research applications. Such data may also offer insights into common neurological insults. We identified a representative, community-based sample of children aged 9-14 years. Children were screened for neurodevelopmental problems. Demographic data, medical history and environmental exposures were ascertained. Eligible children underwent the Neurologic Examination for Subtle Signs (NESS) and a brain MRI. Descriptive findings and analyses to identify risk factors for MRI abnormalities are detailed. One hundred and two of 170 households screened had age-appropriate children. Two of 102 children had neurological problems - one each with cerebral palsy and epilepsy. Ninety-six of 100 eligible children were enrolled. Mean age was 11.9 years (SD 1.5), and 43 (45%) were boys. No acute MRI abnormalities were seen. NESS abnormalities were identified in 6 of 96 children (6%). Radiographic evidence of sinusitis in 29 children (30%) was the most common MRI finding. Brain abnormalities were found in 16 (23%): mild diffuse atrophy in 4 (4%), periventricular white matter changes/gliosis in 6 (6%), multifocal punctuate subcortical white matter changes in 2 (2%), vermian atrophy in 1 (1%), empty sella in 3 (3%) and multifocal granulomas with surrounding gliosis in 1 (1%). Having an abnormal MRI was not associated with age, sex, antenatal problems, early malnutrition, febrile seizures, an abnormal neurological examination or housing quality (all P values >0.05). No predictors of radiographic sinusitis were identified. Incidental brain MRI abnormalities are common in normal Malawian children. The incidental atrophy and white matter abnormalities seen in this African population have not been reported among incidental findings from US populations, suggesting Malawi-specific exposures may be the cause. © 2013 Blackwell Publishing Ltd.

A Concepção de Universo entre Alunos do Ensino Médio de São Paulo e suas Fontes de Aquisição

NASA Astrophysics Data System (ADS)

Araújo, M. A. A.; Elias, D. C. N.; Amaral, L. H.; Araújo, M. S. T.; Voelzke, M. R.

2006-08-01

Nesse trabalho procurou-se identificar por meio de um questionário as concepções de Universo, de espaço e tempo que sustentam a visão de mundo de um grupo de 270 estudantes de Ensino Médio, pertencentes a três escolas de São Paulo. As questões relacionadas aos conhecimentos prévios dos estudantes permitiram constatar que há pouco conhecimento acerca dos temas investigados, destacando-se que apenas 20% dos alunos foram capazes de relacionar as semanas com as fases da lua, enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra e 23% tinham noções das distâncias entre objetos celestes próximos da Terra. Enquanto 56% conseguiram relacionar o Big Bang com a origem do Universo, verificou-se que 37% reconheciam ano-luz como unidade de distância e 60% concebiam o Sol como uma estrela. No que se refere às fontes de aquisição que proporcionaram esses conhecimentos, apesar de 60% dos alunos indicarem a escola como principal fonte dos conhecimentos de Ast! ronomia, verificou-se claramente que para a maioria dos alunos seus conceitos ainda são inadequados, havendo necessidade de aprimoramento da abordagem desses conteúdos, pois apesar de popular, a Astronomia ainda é veiculada de maneira pouco esclarecedora e com imprecisões. Nesse contexto, são discutidas algumas possíveis contribuições que podem ser dadas para o ensino de Astronomia pelo uso das ferramentas computacionais nas escolas.

Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells.

PubMed

Nalaskowski, Marcus M; Ehm, Patrick; Rehbach, Christoph; Nelson, Nina; Täger, Maike; Modest, Kathrin; Jücker, Manfred

2018-05-28

The inositol 5-phosphatase SHIP1 acts as negative regulator of intracellular signaling in myeloid cells and is a tumor suppressor in myeloid leukemogenesis. After relocalization from the cytoplasm to the plasma membrane SHIP1 terminates PI3-kinase mediated signaling processes. Furthermore, SHIP1 is also found in distinct puncta in the cell nucleus and nuclear SHIP1 has a pro-proliferative function. Here we report the identification of five nuclear export signals (NESs) which regulate together with the two known nuclear localization signals (NLSs) the nucleocytoplasmic shuttling of SHIP1. Mutation of NLSs reduced the nuclear import and mutation of NESs decreased the nuclear export of SHIP1 in the acute myeloid leukemia (AML) cell line UKE-1. Interestingly, four SHIP1 mutants (K210R, N508D, V684E, Q1153L) derived from AML patients showed a nuclear accumulation after expression in UKE-1 cells. In addition, overexpression of the AML patient-derived mutation N508D caused an increased proliferation rate of UKE-1 cells in comparison to wild type SHIP1. Furthermore, we identified serine and tyrosine phosphorylation as a molecular mechanism for the regulation of nucleocytoplasmic shuttling of SHIP1 where tyrosine phosphorylation of distinct residues i.e. Y864, Y914, Y1021 reduces nuclear localization, whereas serine phosphorylation at S933 enhances nuclear localization of SHIP1. In summary, our data further implicate nuclear SHIP1 in cellular signaling and suggest that enhanced accumulation of SHIP1 mutants in the nucleus may be a contributory factor of abnormally high proliferation of AML cells. Copyright © 2018 Elsevier Inc. All rights reserved.

Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, Nottingham Eczema Severity Score, and quality of life in patients with atopic dermatitis.

PubMed

Hon, Kam-lun Ellis; Wong, Kin Yee; Leung, Ting-Fan; Chow, Chung-Mo; Ng, Pak-Cheung

2008-01-01

Atopic dermatitis (AD) is characterized by dryness of the skin, pruritus and involvement of the skin flexures. Skin hydration (SH) and integrity, as measured by transepidermal water loss (TEWL), are important parameters for objectively quantifying AD research. To evaluate if sites in the forearm are equivalent to the antecubital fossa for standard SH and TEWL measurements; and to determine the correlations among these measurements and scores of disease severity and quality of life. We evaluated SH and TEWL under standardized conditions at three common measurement sites in the forearm (antecubital flexure, 2 cm below the antecubital flexure, mid-forearm), and determined the SCORing Atopic Dermatitis (SCORAD) score, Nottingham Eczema Severity Score (NESS), and Children's Dermatology Life Quality Index (CDLQI). Significant correlations between clinical scores, SH, and TEWL were obtained at a site 2 cm below the antecubital fossa (r = -0.553, p < 0.001 for SH and SCORAD; r = 0.596, p < 0.001 for TEWL and SCORAD). SH and TEWL were also correlated with long-term severity of AD as measured by NESS (r = -0.494, p = 0.001 for SH; r = 0.430, p = 0.004 for TEWL), while TEWL was significantly correlated with CDLQI (r = 0.323, p = 0.035). Overall, similar significant correlations were obtained at the mid-forearm, but less so at the antecubital fossa. In AD research, three sites on the forearm appear to be convenient for determination of SH and TEWL. This is the first report to demonstrate that significant correlations are obtained among acute and chronic scores of AD disease severity, quality of life, and the bioengineering parameters.

Nonequilibrium phase diagram of a one-dimensional quasiperiodic system with a single-particle mobility edge

NASA Astrophysics Data System (ADS)

Purkayastha, Archak; Dhar, Abhishek; Kulkarni, Manas

2017-11-01

We investigate and map out the nonequilibrium phase diagram of a generalization of the well known Aubry-André-Harper (AAH) model. This generalized AAH (GAAH) model is known to have a single-particle mobility edge which also has an additional self-dual property akin to that of the critical point of the AAH model. By calculating the population imbalance, we get hints of a rich phase diagram. We also find a fascinating connection between single particle wave functions near the mobility edge of the GAAH model and the wave functions of the critical AAH model. By placing this model far from equilibrium with the aid of two baths, we investigate the open system transport via system size scaling of nonequilibrium steady state (NESS) current, calculated by fully exact nonequilibrium Green's function (NEGF) formalism. The critical point of the AAH model now generalizes to a `critical' line separating regions of ballistic and localized transport. Like the critical point of the AAH model, current scales subdiffusively with system size on the `critical' line (I ˜N-2 ±0.1 ). However, remarkably, the scaling exponent on this line is distinctly different from that obtained for the critical AAH model (where I ˜N-1.4 ±0.05 ). All these results can be understood from the above-mentioned connection between states near the mobility edge of the GAAH model and those of the critical AAH model. A very interesting high temperature nonequilibrium phase diagram of the GAAH model emerges from our calculations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christopher Liner

The objective of our work is graduate and undergraduate student training related to improved 3D seismic technology that addresses key challenges related to monitoring movement and containment of CO{sub 2}, specifically better quantification and sensitivity for mapping of caprock integrity, fractures, and other potential leakage pathways. We utilize data and results developed through previous DOE-funded CO{sub 2} characterization project (DE-FG26-06NT42734) at the Dickman Field of Ness County, KS. Dickman is a type locality for the geology that will be encountered for CO{sub 2} sequestration projects from northern Oklahoma across the U.S. midcontinent to Indiana and Illinois. Since its discovery inmore » 1962, the Dickman Field has produced about 1.7 million barrels of oil from porous Mississippian carbonates with a small structural closure at about 4400 ft drilling depth. Project data includes 3.3 square miles of 3D seismic data, 142 wells, with log, some core, and oil/water production data available. Only two wells penetrate the deep saline aquifer. In a previous DOE-funded project, geological and seismic data were integrated to create a geological property model and a flow simulation grid. We believe that sequestration of CO{sub 2} will largely occur in areas of relatively flat geology and simple near surface, similar to Dickman. The challenge is not complex geology, but development of improved, lower-cost methods for detecting natural fractures and subtle faults. Our project used numerical simulation to test methods of gathering multicomponent, full azimuth data ideal for this purpose. Our specific objectives were to apply advanced seismic methods to aide in quantifying reservoir properties and lateral continuity of CO{sub 2} sequestration targets. The purpose of the current project is graduate and undergraduate student training related to improved 3D seismic technology that addresses key challenges related to monitoring movement and containment of CO{sub 2}, specifically better quantification and sensitivity for mapping of caprock integrity, fractures, and other potential leakage pathways. Specifically, our focus is fundamental research on (1) innovative narrow-band seismic data decomposition and interpretation, and (2) numerical simulation of advanced seismic data (multi-component, high density, full azimuth data) ideal for mapping of cap rock integrity and potential leakage pathways.« less

Theory of Semiconducting Superlattices and Microstructures

DTIC Science & Technology

1992-03-01

A)dee on ZnSc layer thic~ness V (number of ZnSe molecules thick) It is Ga ashallowit h do o nu io and s e x de trap (mak.i for N X 10 ZnSe/ZnO,$MnO...ZnSe (which can be easily doped n-type r but not p-type) and ZnTe (which can be doped 15 p-type): de ~ep levels that lie in the gap of ZnSe and btrap...1101 SX. Ren. 3.D. Dow and S. Klemmn. J. Appl. Vh’.-s. in press,search. the Army Research Office, and the De . 111) 3.D. Dow. Run-Di Hong. S, Klemm

Effectiveness of Flood Warning and Preparedness Alternatives.

DTIC Science & Technology

1981-08-01

to shed light on the question of the effective- ness of flood warning and preparedness alternatives and to suggest means of improving effectiveness... dese -1 i he. ti I hc’d liv at lm’-wl’ t I C (I I til I (’W5 1r-d (’Jlls ()ca I tIl (I d Fr l w -ai (otltl 1t h is I- l wt I’ tfll’(d i t it’iI - t, ( 1...the major streams and their t ribu- taries. A-44 Agriculture in the county is gradually decreasing, due at least in part to expansion of urban areas and

Development of a Low Cost Molded Plastic Missile/RPV Control Surface Actuator

DTIC Science & Technology

1975-10-01

Glass Fiber 3 2.1.2.2 Nylon/30% Glaso Fiber 7 2.2 Phase I Testing Of Polyimide/Glass 8 j/ Burst Testsl 11tig 2.2.2atgu TechShatset S.2. Phse Cliner oldng...Dimensional and Hard- 23 a >~ ness Change Results19 2.2.4.2.3 Weight Changes 23 2.2.5 Phase II Environmental Testing 27 II I -ii TALIO ONET TABLE OF...CONTENTS (CONT’D) SECTION PAGE 2.3 Phase I Analysis and Design 27 2.3.1 Sizing and Optimizing AR 27 2.3.2 Valve Sizing 36 2.3.3 Pistons Side Load and Rocker

On the folding phenomenon of comet tail rays

NASA Astrophysics Data System (ADS)

Ershkovich, A. I.

1982-01-01

It is shown that the folding phenomenon of the comet tail rays is compatible with the Ferraro isorotation law if the comet tail magnetic field has no azimuthal component, that is, Bphi (the polar angle) equals zero. Considering electric drift due to convectional electric fields, a formula is obtained for the angular rate of a ray closure which reduces to that of Ness and Donn (1966) if the velocity profile across the tail is linear. The magnetic field B of approximately 20-40 gammas in the coma and less than about 10 gammas in the distant tail is estimated under typical solar wind conditions at 1 AU.

Complex network description of the ionosphere

NASA Astrophysics Data System (ADS)

Lu, Shikun; Zhang, Hao; Li, Xihai; Li, Yihong; Niu, Chao; Yang, Xiaoyun; Liu, Daizhi

2018-03-01

Complex networks have emerged as an essential approach of geoscience to generate novel insights into the nature of geophysical systems. To investigate the dynamic processes in the ionosphere, a directed complex network is constructed, based on a probabilistic graph of the vertical total electron content (VTEC) from 2012. The results of the power-law hypothesis test show that both the out-degree and in-degree distribution of the ionospheric network are not scale-free. Thus, the distribution of the interactions in the ionosphere is homogenous. None of the geospatial positions play an eminently important role in the propagation of the dynamic ionospheric processes. The spatial analysis of the ionospheric network shows that the interconnections principally exist between adjacent geographical locations, indicating that the propagation of the dynamic processes primarily depends on the geospatial distance in the ionosphere. Moreover, the joint distribution of the edge distances with respect to longitude and latitude directions shows that the dynamic processes travel further along the longitude than along the latitude in the ionosphere. The analysis of small-world-ness indicates that the ionospheric network possesses the small-world property, which can make the ionosphere stable and efficient in the propagation of dynamic processes.

Social affordances and the possibility of ecological linguistics.

PubMed

Kono, Tetsuya

2009-12-01

This paper includes an effort to extend the notion of affordance from a philosophical point of view the importance of ecological approach for social psychology, ethics, and linguistics. Affordances are not always merely physical but also interpersonal and social. I will conceptualize affordance in general and social affordance in particular, and will elucidate the relation between intentional action and affordances, and that between affordances and free will. I will also focus on the relation between social institution and affordance. An extended theory of affordances can provide a way to analyze in concrete ways how social institution works as an implicit background of interpersonal interactions. Ecological approach considers social institution as the producer and maintainer of affordances. Social institutions construct the niches for human beings. Finally, I will argue the possibility of the ecological linguistics. Language is a social institution. The system of signs is the way to articulate and differentiate interpersonal affordances. Language acquires its meaning, i.e. communicative power in the interpersonal interactions, and interpersonal interactions, in turn, develop and are elaborated through the usage of signs. Communication is seen as never aimed to transmit inner ideas to others, but to guide and adjust the behaviors of others thorough articulating the affordance of responsible-ness.

Health and Disease at Age 100.

PubMed

Jopp, Daniela S; Boerner, Kathrin; Rott, Christoph

2016-03-25

Centenarian studies from around the world have shown that reaching age 100 typically involves substantial health issues. The present study adds to the existing knowledge from other countries by describing health conditions in German centenarians. A total of 112 centenarians or their primary contacts provided information on acute and chronic health conditions and pain in the context of the Second Heidelberg Centenarian Study (mean age = 100.45 years, standard deviation [SD] = 0.47, 89% females). Participants showed high comorbidity, with an average of five illnesses (mean = 5.3; SD = 2.20). Health conditions with highest prevalence were sensory (vision, hearing; 94%), mobility (72%) and musculoskeletal conditions (60%). Cardiovascular conditions (57%) and urinary system ailments (55%) were also common. Pain was experienced often by 30% of the participants. Of those reporting any pain, 36% indicated pain exceeding bearable levels. German centenarians experienced a substantial number of ill nesses, dominated by sensory and mobility conditions. Cardiovascular diseases were the only potentially lethal illnesses with high prevalence. Evidence of unaddressed pain seems alarming, requiring future research. Emerging health profiles indicate that even in very advanced age, quality of life may be improved by enhanced diagnostics and optimal disease management. Mobility limitations may be addressed with preventive efforts.

Reducing severity of comorbid psychiatric symptoms in an epilepsy clinic using a colocation model: results of a pilot intervention.

PubMed

Chen, Jasper J; Caller, Tracie A; Mecchella, John N; Thakur, Devendra S; Homa, Karen; Finn, Christine T; Kobylarz, Erik J; Bujarski, Krzysztof A; Thadani, Vijay M; Jobst, Barbara C

2014-10-01

Patients with epilepsy (PWEs) and patients with nonepileptic seizures (PWNESs) constitute particularly vulnerable patient populations and have high rates of psychiatric comorbidities. This potentially decreases quality of life and increases health-care utilization and expenditures. However, lack of access to care or concern of stigma may preclude referral to outpatient psychiatric clinics. Furthermore, the optimal treatment for NESs includes longitudinal psychiatric management. No published literature has assessed the impact of colocated psychiatric services within outpatient epilepsy clinics. We, therefore, evaluated the colocation of psychiatric services within a level 4 epilepsy center. From July 2013 to June 2014, we piloted an intervention to colocate a psychiatrist in the Dartmouth-Hitchcock Epilepsy Center outpatient clinic one afternoon a week (0.1 FTE) to provide medication management and time-limited structural psychotherapeutic interventions to all patients who scored greater than 15 on the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and who agreed to referral. Psychiatric symptom severity was assessed at baseline and follow-up visits using validated scales including NDDI-E, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and cognitive subscale items from Quality of Life in Epilepsy-31 (QOLIE-31) scores. Forty-three patients (18 males; 25 females) were referred to the clinic over a one-year interval; 27 (64.3%) were seen in follow-up with a median of 3 follow-up visits (range: 1 to 7). Thirty-seven percent of the patients had NESs exclusive of epilepsy, and 11% of the patients had dual diagnosis of epilepsy and NESs. Psychiatric symptom severity decreased in 84% of the patients, with PHQ-9 and GAD-7 scores improving significantly from baseline (4.6±0.4 SD improvement in PHQ-9 and 4.0±0.4 SD improvement in GAD-7, p-values<0.001). Cognitive subitem scores for NDDI-E and QOLIE-31 at their most recent visit were significantly improved compared with nadir scores (3.3±0.6 SD improvement in NDDI-E and 1.5±0.2 SD improvement in QOLIE-31, p-values<0.001). These results are, moreover, clinically significant-defined as improvement by 4-5 points on PHQ-9 and GAD-7 instruments-and are correlated with overall improvement as measured by NDDI-E and cognitive subscale QOLIE-31 items. A colocated psychiatrist demonstrated reduction in psychiatric symptoms of PWEs and PWNESs, improving psychiatric access and streamlining their care. Epileptologists were able to dedicate more time to managing epilepsy as opposed to psychiatric comorbidities. As integrated models of collaborative and colocated care are becoming more widespread, mental health-care providers located in outpatient neurology clinics may benefit both patients and providers. Copyright © 2014 Elsevier Inc. All rights reserved.

Real time digital propulsion system simulation for manned flight simulators

NASA Technical Reports Server (NTRS)

Mihaloew, J. R.; Hart, C. E.

1978-01-01

A real time digital simulation of a STOL propulsion system was developed which generates significant dynamics and internal variables needed to evaluate system performance and aircraft interactions using manned flight simulators. The simulation ran at a real-to-execution time ratio of 8.8. The model was used in a piloted NASA flight simulator program to evaluate the simulation technique and the propulsion system digital control. The simulation is described and results shown. Limited results of the flight simulation program are also presented.

Evaluation of Nd:YVO4 and Ho:Er:Tm:YVO4 as Pulse Pumped Q-Switched Lasers

DTIC Science & Technology

1976-01-01

550t 10° L-4:1+YV04 L-4:1+5:1 in o > o N 1 Y 2o3 20 O > YVO4 + Liquid YVO4 + v2o5 672 t 3° J I J I 40 60 Mol.% 80 v2o. Figure 1...hardness of 480 KHN which is the range of many glasses and as such polishes, saws, and grinds well. The major problem is that of cleavage along...excellent optical finishing properties because of its glass -like hard- ness, it has only a slight tendency to cleave, and it has a high laser-induced

Warriors Edge Simulation and Gaming System: The Squad Simulation

DTIC Science & Technology

2005-08-01

Warriors Edge Simulation and Gaming System: The Squad Simulation by Mark Thomas and Gary Moss ARL-TR-3564 August 2005...Edge Simulation and Gaming System: The Squad Simulation Mark Thomas and Gary Moss Computational and Information Sciences Directorate, ARL...2004–30 September 2004 5a. CONTRACT NUMBER 5b. GRANT NUMBER 4. TITLE AND SUBTITLE Warriors Edge Simulation and Gaming System: The Squad

Expert systems and simulation models; Proceedings of the Seminar, Tucson, AZ, November 18, 19, 1985

NASA Technical Reports Server (NTRS)

1986-01-01

The seminar presents papers on modeling and simulation methodology, artificial intelligence and expert systems, environments for simulation/expert system development, and methodology for simulation/expert system development. Particular attention is given to simulation modeling concepts and their representation, modular hierarchical model specification, knowledge representation, and rule-based diagnostic expert system development. Other topics include the combination of symbolic and discrete event simulation, real time inferencing, and the management of large knowledge-based simulation projects.

Construction of multi-functional open modulized Matlab simulation toolbox for imaging ladar system

NASA Astrophysics Data System (ADS)

Wu, Long; Zhao, Yuan; Tang, Meng; He, Jiang; Zhang, Yong

2011-06-01

Ladar system simulation is to simulate the ladar models using computer simulation technology in order to predict the performance of the ladar system. This paper presents the developments of laser imaging radar simulation for domestic and overseas studies and the studies of computer simulation on ladar system with different application requests. The LadarSim and FOI-LadarSIM simulation facilities of Utah State University and Swedish Defence Research Agency are introduced in details. This paper presents the low level of simulation scale, un-unified design and applications of domestic researches in imaging ladar system simulation, which are mostly to achieve simple function simulation based on ranging equations for ladar systems. Design of laser imaging radar simulation with open and modularized structure is proposed to design unified modules for ladar system, laser emitter, atmosphere models, target models, signal receiver, parameters setting and system controller. Unified Matlab toolbox and standard control modules have been built with regulated input and output of the functions, and the communication protocols between hardware modules. A simulation based on ICCD gain-modulated imaging ladar system for a space shuttle is made based on the toolbox. The simulation result shows that the models and parameter settings of the Matlab toolbox are able to simulate the actual detection process precisely. The unified control module and pre-defined parameter settings simplify the simulation of imaging ladar detection. Its open structures enable the toolbox to be modified for specialized requests. The modulization gives simulations flexibility.

The role of the research simulator in the systems development of rotorcraft

NASA Technical Reports Server (NTRS)

Statler, I. C.; Deel, A.

1981-01-01

The potential application of the research simulator to future rotorcraft systems design, development, product improvement evaluations, and safety analysis is examined. Current simulation capabilities for fixed-wing aircraft are reviewed and the requirements of a rotorcraft simulator are defined. The visual system components, vertical motion simulator, cab, and computation system for a research simulator under development are described.

Advanced EMT and Phasor-Domain Hybrid Simulation with Simulation Mode Switching Capability for Transmission and Distribution Systems

DOE PAGES

Huang, Qiuhua; Vittal, Vijay

2018-05-09

Conventional electromagnetic transient (EMT) and phasor-domain hybrid simulation approaches presently exist for trans-mission system level studies. Their simulation efficiency is generally constrained by the EMT simulation. With an increasing number of distributed energy resources and non-conventional loads being installed in distribution systems, it is imperative to extend the hybrid simulation application to include distribution systems and integrated transmission and distribution systems. Meanwhile, it is equally important to improve the simulation efficiency as the modeling scope and complexity of the detailed system in the EMT simulation increases. To meet both requirements, this paper introduces an advanced EMT and phasor-domain hybrid simulationmore » approach. This approach has two main features: 1) a comprehensive phasor-domain modeling framework which supports positive-sequence, three-sequence, three-phase and mixed three-sequence/three-phase representations and 2) a robust and flexible simulation mode switching scheme. The developed scheme enables simulation switching from hybrid simulation mode back to pure phasor-domain dynamic simulation mode to achieve significantly improved simulation efficiency. The proposed method has been tested on integrated transmission and distribution systems. In conclusion, the results show that with the developed simulation switching feature, the total computational time is significantly reduced compared to running the hybrid simulation for the whole simulation period, while maintaining good simulation accuracy.« less

Advanced EMT and Phasor-Domain Hybrid Simulation with Simulation Mode Switching Capability for Transmission and Distribution Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Qiuhua; Vittal, Vijay

Conventional electromagnetic transient (EMT) and phasor-domain hybrid simulation approaches presently exist for trans-mission system level studies. Their simulation efficiency is generally constrained by the EMT simulation. With an increasing number of distributed energy resources and non-conventional loads being installed in distribution systems, it is imperative to extend the hybrid simulation application to include distribution systems and integrated transmission and distribution systems. Meanwhile, it is equally important to improve the simulation efficiency as the modeling scope and complexity of the detailed system in the EMT simulation increases. To meet both requirements, this paper introduces an advanced EMT and phasor-domain hybrid simulationmore » approach. This approach has two main features: 1) a comprehensive phasor-domain modeling framework which supports positive-sequence, three-sequence, three-phase and mixed three-sequence/three-phase representations and 2) a robust and flexible simulation mode switching scheme. The developed scheme enables simulation switching from hybrid simulation mode back to pure phasor-domain dynamic simulation mode to achieve significantly improved simulation efficiency. The proposed method has been tested on integrated transmission and distribution systems. In conclusion, the results show that with the developed simulation switching feature, the total computational time is significantly reduced compared to running the hybrid simulation for the whole simulation period, while maintaining good simulation accuracy.« less

EHR adoption among doctors who treat the elderly.

PubMed

Yeager, Valerie A; Menachemi, Nir; Brooks, Robert G

2010-12-01

The purpose of this study is to examine Electronic Health Record (EHR) adoption among Florida doctors who treat the elderly. This analysis contributes to the EHR adoption literature by determining if doctors who disproportionately treat the elderly differ from their counterparts with respect to the utilization of an important quality-enhancing health information technology application. This study is based on a primary survey of a large, statewide sample of doctors practising in outpatient settings in Florida. Logistic regression analysis was used to determine whether doctors who treat a high volume of elderly (HVE) patients were different with respect to EHR adoption. Our analyses included responses from 1724 doctors. In multivariate analyses controlling for doctor age, training, computer sophistication, practice size and practice setting, HVE doctors were significantly less likely to adopt EHR. Specifically, compared with their counterparts, HVE doctors were observed to be 26.7% less likely to be utilizing an EHR system (OR=0.733, 95% CI 0.547-0.982). We also found that doctor age is negatively related to EHR adoption, and practice size and doctor computer savvy-ness is positively associated. Despite the fact that EHR adoption has improved in recent years, doctors in Florida who serve the elderly are less likely to adopt EHRs. As long as HVE doctors are adopting EHR systems at slower rates, the elderly patients treated by these doctors will be at a disadvantage with respect to potential benefits offered by this technology. © 2010 Blackwell Publishing Ltd.

Development and training of a learning expert system in an autonomous mobile robot via simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spelt, P.F.; Lyness, E.; DeSaussure, G.

1989-11-01

The Center for Engineering Systems Advanced Research (CESAR) conducts basic research in the area of intelligent machines. Recently at CESAR a learning expert system was created to operate on board an autonomous robot working at a process control panel. The authors discuss two-computer simulation system used to create, evaluate and train this learning system. The simulation system has a graphics display of the current status of the process being simulated, and the same program which does the simulating also drives the actual control panel. Simulation results were validated on the actual robot. The speed and safety values of using amore » computerized simulator to train a learning computer, and future uses of the simulation system, are discussed.« less

Workshop on data acquisition and trigger system simulations for high energy physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1992-12-31

This report discusses the following topics: DAQSIM: A data acquisition system simulation tool; Front end and DCC Simulations for the SDC Straw Tube System; Simulation of Non-Blocklng Data Acquisition Architectures; Simulation Studies of the SDC Data Collection Chip; Correlation Studies of the Data Collection Circuit & The Design of a Queue for this Circuit; Fast Data Compression & Transmission from a Silicon Strip Wafer; Simulation of SCI Protocols in Modsim; Visual Design with vVHDL; Stochastic Simulation of Asynchronous Buffers; SDC Trigger Simulations; Trigger Rates, DAQ & Online Processing at the SSC; Planned Enhancements to MODSEM II & SIMOBJECT -- anmore » Overview -- R.; DAGAR -- A synthesis system; Proposed Silicon Compiler for Physics Applications; Timed -- LOTOS in a PROLOG Environment: an Algebraic language for Simulation; Modeling and Simulation of an Event Builder for High Energy Physics Data Acquisition Systems; A Verilog Simulation for the CDF DAQ; Simulation to Design with Verilog; The DZero Data Acquisition System: Model and Measurements; DZero Trigger Level 1.5 Modeling; Strategies Optimizing Data Load in the DZero Triggers; Simulation of the DZero Level 2 Data Acquisition System; A Fast Method for Calculating DZero Level 1 Jet Trigger Properties and Physics Input to DAQ Studies.« less

Research of laser echo signal simulator

NASA Astrophysics Data System (ADS)

Xu, Rui; Shi, Rui; Wang, Xin; Li, Zhou

2015-11-01

Laser echo signal simulator is one of the most significant components of hardware-in-the-loop (HWIL) simulation systems for LADAR. System model and time series model of laser echo signal simulator are established. Some influential factors which could induce fixed error and random error on the simulated return signals are analyzed, and then these system insertion errors are analyzed quantitatively. Using this theoretical model, the simulation system is investigated experimentally. The results corrected by subtracting fixed error indicate that the range error of the simulated laser return signal is less than 0.25m, and the distance range that the system can simulate is from 50m to 20km.

Computational simulation of concurrent engineering for aerospace propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1992-01-01

Results are summarized of an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering. These results demonstrate that development of computational simulations methods for concurrent engineering is timely. Extensive infrastructure, in terms of multi-discipline simulation, component-specific simulation, system simulators, fabrication process simulation, and simulation of uncertainties - fundamental in developing such methods, is available. An approach is recommended which can be used to develop computational simulation methods for concurrent engineering for propulsion systems and systems in general. Benefits and facets needing early attention in the development are outlined.

Computational simulation for concurrent engineering of aerospace propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1993-01-01

Results are summarized for an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering. These results demonstrate that development of computational simulation methods for concurrent engineering is timely. Extensive infrastructure, in terms of multi-discipline simulation, component-specific simulation, system simulators, fabrication process simulation, and simulation of uncertainties--fundamental to develop such methods, is available. An approach is recommended which can be used to develop computational simulation methods for concurrent engineering of propulsion systems and systems in general. Benefits and issues needing early attention in the development are outlined.

Computational simulation for concurrent engineering of aerospace propulsion systems

NASA Astrophysics Data System (ADS)

Chamis, C. C.; Singhal, S. N.

1993-02-01

Results are summarized for an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering. These results demonstrate that development of computational simulation methods for concurrent engineering is timely. Extensive infrastructure, in terms of multi-discipline simulation, component-specific simulation, system simulators, fabrication process simulation, and simulation of uncertainties--fundamental to develop such methods, is available. An approach is recommended which can be used to develop computational simulation methods for concurrent engineering of propulsion systems and systems in general. Benefits and issues needing early attention in the development are outlined.

Quality of life and psychosocial issues are important outcome measures in eczema treatment.

PubMed

Hon, Kam Lun; Pong, N H; Poon, Terence C W; Chan, Dorothy F Y; Leung, T F; Lai, Kelly Y C; Wing, Y K; Luk, Nai Ming

2015-02-01

Atopic eczema (AE) is a common relapsing inflammatory skin disease in children associated with chronicity and poor quality of life. Many children also display depressive, anxiety and stress symptoms. To investigate the prevalence of depressive, anxiety and stress symptoms, and if these symptoms are associated with disease severity, quality of life and skin biophysiology in childhood AE. Psychological symptoms, eczema severity, quality of life and biophysical skin condition of consecutive adolescents at the pediatric dermatology clinic of a teaching hospital were evaluated with the validated Chinese versions of Depressive, Anxiety, Stress Scales (DASS-42), Beck Depression Inventory (BDI-13), Nottingham Eczema Severity Score (NESS), Children's Dermatology Life Quality Index (CDLQI), transepidermal water loss (TEWL) and stratum corneum skin hydration (SH), respectively. AE patients (n=120) had lower SH, higher TEWL, worse CDLQI and reported higher overall, depressive and stress symptom scores, personal history of atopy, current topical corticosteroid usage and food avoidance than non-AE patients (n=26). Depressive, anxiety and stress symptoms were reported in 21%, 33% and 23% of AE patients, respectively. Multivariate analyses showed that these symptoms were significantly correlated with a poor quality of life (partial correlations of 0.40-0.49; p<0.001). Male patients had more severe disease (higher NESS, p=0.036) and DASS-depressive symptoms (multivariate OR=3.2, p=0.034) than females. Patients who reported current topical steroid usage generally practiced food avoidance (p=0.047), had poor quality of life (p=0.043) but less DASS-depression (multivariate OR=0.354, p=0.043). Only 6% of the 120 AE patients reported prior psychology consultation. Quality of life impairments correlate with disease severity, aberrant skin biophysiology, depression, anxiety and stress symptoms in adolescents with AE. Physicians caring for these patients must evaluate the different but inter-correlated medical, biophysiological and pertinent psychosocial domains. These significant correlations imply that a holistic approach should encompass psychotherapy, behavioral therapy and coping strategies in conjunction with dermatologic therapy.

Correlations among steroid fear, acceptability, usage frequency, quality of life and disease severity in childhood eczema.

PubMed

Hon, Kam Lun; Tsang, Yin Ching K; Pong, Nga Hin; Luk, David C K; Lee, Vivian W; Woo, Wing Man; Lam, Chak Yiu Justin; Yeung, Yun Ting Eunice; Chau, Yiu Shing Sunny; Chui, Ka Kam Kenneth; Li, Ka Hin Gabriel; Leung, Ting Fan

2015-10-01

Topical corticosteroids (CSs) are the mainstay of treatment for eczema but CS phobia and fears are prevalent and influence therapeutic efficacy. To quantify if CS acceptability and fear affect patients' quality-of-life (QoL). Patients with eczema managed in the pediatric dermatology outpatient clinic of a university hospital were surveyed. Nottingham Eczema Severity Score (NESS) for severity, Children's Dermatology Life Quality Index (CDLQI) for QoL, CS fear, acceptability and reported frequency of CS use were measured with quantified questions. CS fears were prevalent among parents and caregivers of patients with eczema. Fifty-eight percent of parents reported general acceptability of CS as being very good or good, and many applied CS to their child regularly every week. However, >40% of parents reported CS fear "always" or "often", 41% reported that they "always" or "often" apply CS only when eczema got worse, 57% would discuss CS fear with their doctors, 30% would request CS-sparing medications and 14% "always" or "often" use traditional Chinese herbal medicine. Fears were predominantly interpersonal and less often iatrogenic in nature. Skin problems were the most concerned side effects of CS. CS acceptability, frequency of CS usage, CS fear and usage of alternative medications were independent domains in eczema management: CS fears correlated with CDLQI; CS usage frequency correlated with NESS and negatively with parental education; and CS acceptability correlated with parental education. Ordinal logistic regressions showed worse QoL was associated with more CS fear (odds ratio: 1.092 [95% CI: 1.023-1.165], p = 0.008). The extent of CS fears is independent of CS acceptability, but correlates with patients' QoL. Desensitization of parental CS fears should be integral part of eczema education and therapeutics in order to improve therapeutic efficacy and patients' QoL.

Durham extremely large telescope adaptive optics simulation platform.

PubMed

Basden, Alastair; Butterley, Timothy; Myers, Richard; Wilson, Richard

2007-03-01

Adaptive optics systems are essential on all large telescopes for which image quality is important. These are complex systems with many design parameters requiring optimization before good performance can be achieved. The simulation of adaptive optics systems is therefore necessary to categorize the expected performance. We describe an adaptive optics simulation platform, developed at Durham University, which can be used to simulate adaptive optics systems on the largest proposed future extremely large telescopes as well as on current systems. This platform is modular, object oriented, and has the benefit of hardware application acceleration that can be used to improve the simulation performance, essential for ensuring that the run time of a given simulation is acceptable. The simulation platform described here can be highly parallelized using parallelization techniques suited for adaptive optics simulation, while still offering the user complete control while the simulation is running. The results from the simulation of a ground layer adaptive optics system are provided as an example to demonstrate the flexibility of this simulation platform.

Automated simulation as part of a design workstation

NASA Technical Reports Server (NTRS)

Cantwell, E.; Shenk, T.; Robinson, P.; Upadhye, R.

1990-01-01

A development project for a design workstation for advanced life-support systems incorporating qualitative simulation, required the implementation of a useful qualitative simulation capability and the integration of qualitative and quantitative simulations, such that simulation capabilities are maximized without duplication. The reason is that to produce design solutions to a system goal, the behavior of the system in both a steady and perturbed state must be represented. The paper reports on the Qualitative Simulation Tool (QST), on an expert-system-like model building and simulation interface toll called ScratchPad (SP), and on the integration of QST and SP with more conventional, commercially available simulation packages now being applied in the evaluation of life-support system processes and components.

Designing a SCADA system simulator for fast breeder reactor

NASA Astrophysics Data System (ADS)

Nugraha, E.; Abdullah, A. G.; Hakim, D. L.

2016-04-01

SCADA (Supervisory Control and Data Acquisition) system simulator is a Human Machine Interface-based software that is able to visualize the process of a plant. This study describes the results of the process of designing a SCADA system simulator that aims to facilitate the operator in monitoring, controlling, handling the alarm, accessing historical data and historical trend in Nuclear Power Plant (NPP) type Fast Breeder Reactor (FBR). This research used simulation to simulate NPP type FBR Kalpakkam in India. This simulator was developed using Wonderware Intouch software 10 and is equipped with main menu, plant overview, area graphics, control display, set point display, alarm system, real-time trending, historical trending and security system. This simulator can properly simulate the principle of energy flow and energy conversion process on NPP type FBR. This SCADA system simulator can be used as training media for NPP type FBR prospective operators.

Space Station communications and tracking systems modeling and RF link simulation

NASA Technical Reports Server (NTRS)

Tsang, Chit-Sang; Chie, Chak M.; Lindsey, William C.

1986-01-01

In this final report, the effort spent on Space Station Communications and Tracking System Modeling and RF Link Simulation is described in detail. The effort is mainly divided into three parts: frequency division multiple access (FDMA) system simulation modeling and software implementation; a study on design and evaluation of a functional computerized RF link simulation/analysis system for Space Station; and a study on design and evaluation of simulation system architecture. This report documents the results of these studies. In addition, a separate User's Manual on Space Communications Simulation System (SCSS) (Version 1) documents the software developed for the Space Station FDMA communications system simulation. The final report, SCSS user's manual, and the software located in the NASA JSC system analysis division's VAX 750 computer together serve as the deliverables from LinCom for this project effort.

An Integrated Modeling and Simulation Methodology for Intelligent Systems Design and Testing

DTIC Science & Technology

2002-08-01

simulation and actual execution. KEYWORDS: Model Continuity, Modeling, Simulation, Experimental Frame, Real Time Systems , Intelligent Systems...the methodology for a stand-alone real time system. Then it will scale up to distributed real time systems . For both systems, step-wise simulation...MODEL CONTINUITY Intelligent real time systems monitor, respond to, or control, an external environment. This environment is connected to the digital

Collaborative simulation method with spatiotemporal synchronization process control

NASA Astrophysics Data System (ADS)

Zou, Yisheng; Ding, Guofu; Zhang, Weihua; Zhang, Jian; Qin, Shengfeng; Tan, John Kian

2016-10-01

When designing a complex mechatronics system, such as high speed trains, it is relatively difficult to effectively simulate the entire system's dynamic behaviors because it involves multi-disciplinary subsystems. Currently,a most practical approach for multi-disciplinary simulation is interface based coupling simulation method, but it faces a twofold challenge: spatial and time unsynchronizations among multi-directional coupling simulation of subsystems. A new collaborative simulation method with spatiotemporal synchronization process control is proposed for coupling simulating a given complex mechatronics system across multiple subsystems on different platforms. The method consists of 1) a coupler-based coupling mechanisms to define the interfacing and interaction mechanisms among subsystems, and 2) a simulation process control algorithm to realize the coupling simulation in a spatiotemporal synchronized manner. The test results from a case study show that the proposed method 1) can certainly be used to simulate the sub-systems interactions under different simulation conditions in an engineering system, and 2) effectively supports multi-directional coupling simulation among multi-disciplinary subsystems. This method has been successfully applied in China high speed train design and development processes, demonstrating that it can be applied in a wide range of engineering systems design and simulation with improved efficiency and effectiveness.

Real-time visual simulation of APT system based on RTW and Vega

NASA Astrophysics Data System (ADS)

Xiong, Shuai; Fu, Chengyu; Tang, Tao

2012-10-01

The Matlab/Simulink simulation model of APT (acquisition, pointing and tracking) system is analyzed and established. Then the model's C code which can be used for real-time simulation is generated by RTW (Real-Time Workshop). Practical experiments show, the simulation result of running the C code is the same as running the Simulink model directly in the Matlab environment. MultiGen-Vega is a real-time 3D scene simulation software system. With it and OpenGL, the APT scene simulation platform is developed and used to render and display the virtual scenes of the APT system. To add some necessary graphics effects to the virtual scenes real-time, GLSL (OpenGL Shading Language) shaders are used based on programmable GPU. By calling the C code, the scene simulation platform can adjust the system parameters on-line and get APT system's real-time simulation data to drive the scenes. Practical application shows that this visual simulation platform has high efficiency, low charge and good simulation effect.

Challenge for more precise e- and ion-transport in gases and liquids

NASA Astrophysics Data System (ADS)

White, Ron

2016-09-01

The full potential of technologies driven by non-equilibrium electron and ion processes in gases, liquids and soft-matter can only be realised once the basic physics has been mastered. The central component in this pursuit is an ever increasing need for the precise determination of electron and ion transport in such media. Over the last few decades, the group at James Cook University and collaborators have developed a suite of multi-term Boltzmann equation solutions to treat temporal and spatial non-locality for electrons and ions in electric and magnetic fields in gaseous systems. In this presentation, we will highlight recent developments including (i) a space-time multi-term solution of Boltzmann's equation; (ii) a unified treatment of electron and ion solutions of Boltzmann's equation which avoids mass ratio expansions; (iii) the treatment dense gases and liquids, including coherent scattering, screened potentials and (self) trapped bubble state effects, the latter of which can give rise to fractional transport behaviour, and (iv) the application to consider the self-consistency of cross-sections for electrons in biomolecules. Contributors: G. Boyle, P. Stokes, M. Casey, N. Garland, D. Cocks, D. Konovalov, S. Dujko, R. E. Robson, K. F. Ness, M. Brunger, S. Buckman, J. de Urquijo and Z. Lj. Petrovic. Support: Australian Research Council.

Stress Judgment and Production in English Derivation, and Word Reading in Adult Mandarin-Speaking English Learners.

PubMed

Chung, Wei-Lun; Jarmulowicz, Linda

2017-08-01

For monolingual English-speaking children, judgment and production of stress in derived words, including words with phonologically neutral (e.g., -ness) and non-neutral suffixes (e.g., -ity), is important to both academic vocabulary growth and to word reading. For Mandarin-speaking adult English learners (AELs) the challenge of learning the English stress system might be complicated by cross-linguistic differences in prosodic function and features. As Mandarin-speakers become more proficient in English, patterns similar to those seen in monolingual children could emerge in which awareness and use of stress and suffix cues benefit word reading. A correlational design was used to examine the contributions of English stress in derivation with neutral and non-neutral suffixes to English word and nonword reading. Stress judgment in non-neutral derivation predicted word reading after controlling for working memory and English vocabulary; whereas stress production in neutral derivation contributed to word reading and pseudoword decoding, independent of working memory and English vocabulary. Although AELs could use stress and suffix cues for word reading, AELs were different from native English speakers in awareness of non-neutral suffix cues conditioning lexical stress placement. AELs may need to rely on lexical storage of primary stress in derivations with non-neutral suffixes.

Camera/Photometer Results

NASA Astrophysics Data System (ADS)

Clifton, K. S.; Owens, J. K.

1983-04-01

Efforts continue regarding the analysis of particulate contamination recorded by the Camera/Photometers on STS-2. These systems were constructed by Epsilon Laboratories, Inc. and consisted of two 16-mm photographic cameras, using Kodak Double X film, Type 7222, to make stereoscopic observations of contaminant particles and background. Each was housed within a pressurized canister and operated automatically throughout the mission, making simultaneous exposures on a continuous basis every 150 sec. The cameras were equipped with 18-mm f/0.9 lenses and subtended overlapping 20° fields-of-view. An integrating photometer was used to inhibit the exposure sequences during periods of excessive illumination and to terminate the exposures at preset light levels. During the exposures, a camera shutter operated in a chopping mode in order to isolate the movement of particles for velocity determinations. Calculations based on the preflight film calibration indicate that particles as small as 25 μm can be detected from ideal observing conditions. Current emphasis is placed on the digitization of the photographic data frames and the determination of particle distances, sizes, and velocities. It has been concluded that background bright-ness measurements cannot be established with any reliability on the STS-2 mission, due to the preponderance of Earth-directed attitudes and the incidence of light reflected from nearby surfaces.

Development of the KOSMS management simulation training system and its application

NASA Astrophysics Data System (ADS)

Takatsu, Yoshiki

The use of games which simulate actual corporate management has recently become more common and is now utilized in various ways for in-house corporate training courses. KOSMS (Kobe Steel Management Simulation System), a training system designed to help improve the management skills of senior management staff, is a unique management simulation training system in which the participants, using personal computers, must make decisions concerning a variety of management activities, in simulated competition with other corporations. This report outlines the KOSMS system, and describes the basic structure and detailed contents of the management simulation models, and actual application of the KOSMS management simulation training.

Intermediate Fidelity Closed Brayton Cycle Power Conversion Model

NASA Technical Reports Server (NTRS)

Lavelle, Thomas M.; Khandelwal, Suresh; Owen, Albert K.

2006-01-01

This paper describes the implementation of an intermediate fidelity model of a closed Brayton Cycle power conversion system (Closed Cycle System Simulation). The simulation is developed within the Numerical Propulsion Simulation System architecture using component elements from earlier models. Of particular interest, and power, is the ability of this new simulation system to initiate a more detailed analysis of compressor and turbine components automatically and to incorporate the overall results into the general system simulation.

A new approach to enforce element-wise mass/species balance using the augmented Lagrangian method

NASA Astrophysics Data System (ADS)

Chang, J.; Nakshatrala, K.

2015-12-01

The least-squares finite element method (LSFEM) is one of many ways in which one can discretize and express a set of first ordered partial differential equations as a mixed formulation. However, the standard LSFEM is not locally conservative by design. The absence of this physical property can have serious implications in the numerical simulation of subsurface flow and transport. Two commonly employed ways to circumvent this issue is through the Lagrange multiplier method, which explicitly satisfies the element-wise divergence by introducing new unknowns, or through appending a penalty factor to the continuity constraint, which reduces the violation in the mass balance. However, these methodologies have some well-known drawbacks. Herein, we propose a new approach to improve the local balance of species/mass balance. The approach augments constraints to a least-square function by a novel mathematical construction of the local species/mass balance, which is different from the conventional ways. The resulting constrained optimization problem is solved using the augmented Lagrangian, which corrects the balance errors in an iterative fashion. The advantages of this methodology are that the problem size is not increased (thus preserving the symmetry and positive definite-ness) and that one need not provide an accurate guess for the initial penalty to reach a prescribed mass balance tolerance. We derive the least-squares weighting needed to ensure accurate solutions. We also demonstrate the robustness of the weighted LSFEM coupled with the augmented Lagrangian by solving large-scale heterogenous and variably saturated flow through porous media problems. The performance of the iterative solvers with respect to various user-defined augmented Lagrangian parameters will be documented.

A real time Pegasus propulsion system model for VSTOL piloted simulation evaluation

NASA Technical Reports Server (NTRS)

Mihaloew, J. R.; Roth, S. P.; Creekmore, R.

1981-01-01

A real time propulsion system modeling technique suitable for use in man-in-the-loop simulator studies was developd. This technique provides the system accuracy, stability, and transient response required for integrated aircraft and propulsion control system studies. A Pegasus-Harrier propulsion system was selected as a baseline for developing mathematical modeling and simulation techniques for VSTOL. Initially, static and dynamic propulsion system characteristics were modeled in detail to form a nonlinear aerothermodynamic digital computer simulation of a Pegasus engine. From this high fidelity simulation, a real time propulsion model was formulated by applying a piece-wise linear state variable methodology. A hydromechanical and water injection control system was also simulated. The real time dynamic model includes the detail and flexibility required for the evaluation of critical control parameters and propulsion component limits over a limited flight envelope. The model was programmed for interfacing with a Harrier aircraft simulation. Typical propulsion system simulation results are presented.

Simulation Framework for Intelligent Transportation Systems

DOT National Transportation Integrated Search

1996-10-01

A simulation framework has been developed for a large-scale, comprehensive, scaleable simulation of an Intelligent Transportation System. The simulator is designed for running on parellel computers and distributed (networked) computer systems, but ca...

Automated simulation as part of a design workstation

NASA Technical Reports Server (NTRS)

Cantwell, Elizabeth; Shenk, T.; Robinson, P.; Upadhye, R.

1990-01-01

A development project for a design workstation for advanced life-support systems (called the DAWN Project, for Design Assistant Workstation), incorporating qualitative simulation, required the implementation of a useful qualitative simulation capability and the integration of qualitative and quantitative simulation such that simulation capabilities are maximized without duplication. The reason is that to produce design solutions to a system goal, the behavior of the system in both a steady and perturbed state must be represented. The Qualitative Simulation Tool (QST), on an expert-system-like model building and simulation interface toll called ScratchPad (SP), and on the integration of QST and SP with more conventional, commercially available simulation packages now being applied in the evaluation of life-support system processes and components are discussed.

Concept verification of three dimensional free motion simulator for space robot

NASA Technical Reports Server (NTRS)

Okamoto, Osamu; Nakaya, Teruomi; Pokines, Brett

1994-01-01

In the development of automatic assembling technologies for space structures, it is an indispensable matter to investigate and simulate the movements of robot satellites concerned with mission operation. The movement investigation and simulation on the ground will be effectively realized by a free motion simulator. Various types of ground systems for simulating free motion have been proposed and utilized. Some of these methods are a neutral buoyancy system, an air or magnetic suspension system, a passive suspension balance system, and a free flying aircraft or drop tower system. In addition, systems can be simulated by computers using an analytical model. Each free motion simulation method has limitations and well known problems, specifically, disturbance by water viscosity, limited number of degrees-of-freedom, complex dynamics induced by the attachment of the simulation system, short experiment time, and the lack of high speed super-computer simulation systems, respectively. The basic idea presented here is to realize 3-dimensional free motion. This is achieved by combining a spherical air bearing, a cylindrical air bearing, and a flat air bearing. A conventional air bearing system has difficulty realizing free vertical motion suspension. The idea of free vertical suspension is that a cylindrical air bearing and counter balance weight realize vertical free motion. This paper presents a design concept, configuration, and basic performance characteristics of an innovative free motion simulator. A prototype simulator verifies the feasibility of 3-dimensional free motion simulation.

Semantic transparency affects morphological priming . . . eventually.

PubMed

Heyer, Vera; Kornishova, Dana

2018-05-01

Semantic transparency has been in the focus of psycholinguistic research for decades, with the controversy about the time course of the application of morpho-semantic information during the processing of morphologically complex words not yet resolved. This study reports two masked priming studies with English - ness and Russian - ost' nominalisations, investigating how semantic transparency modulates native speakers' morphological priming effects at short and long stimulus onset asynchronies (SOAs). In both languages, we found increased morphological priming for nominalisations at the transparent end of the scale (e.g. paleness - pale) in comparison to items at the opaque end of the scale (e.g. business - busy) but only at longer prime durations. The present findings are in line with models that posit an initial phase of morpho-orthographic (semantically blind) decomposition.

Altitude of the top of the Sparta Sand and Memphis Sand in three areas of Arkansas

USGS Publications Warehouse

Pugh, Aaron L.; Westerfield, Paul W.; Gonthier, Gerard; Poynter, David T.

1998-01-01

The Sparta Sand and Memphis Sand form the second most productive aquifer in Arkansas. The Sparta Sand and Memphis Sand range in thick- ness from 0 to 900 feet, consisting of fine- to medium-grained sands interbedded with layers of silt, clay, shale, and minor amounts of lignite. Within the three areas of interest, the top surface of the Sparta Sand and Memphis Sand dips regionally east and southeast towards the axis of the Mississippi Embayment syncline and Desha Basin. Local variations in the top surface may be attributed to a combination of continued development of structural features, differential compaction, localized faulting, and erosion of the surface prior to subsequent inundation and deposition of younger sediments.

X-Shaped Bulge in the Milky Way

NASA Image and Video Library

2016-07-19

In 2010, NASA's Wide-field Infrared Survey Explorer (WISE) mission observed the entire sky twice. Astronomers used these data to point out the X-shaped structure in the bulge of the Milky Way, contained in the small circle at center, as well as the inset image. The circled central portion covers roughly the area of sky that would be blocked by a basketball when held out at arm's length. Dustin Lang, an astronomer at the Dunlap Institute of the University of Toronto, used these data to make this map, which shows the full 360-degree panorama of the sky as seen by WISE. Lang collaborated with Melissa Ness, postdoctoral researcher at the Max Planck Institute for Astronomy in Germany, http://photojournal.jpl.nasa.gov/catalog/PIA20699

Ethnic boxes: the unintended consequences of Habsburg bureaucratic classification

PubMed Central

2018-01-01

The classificatory efforts that accompanied the modernization of the Habsburg state inadvertently helped establish, promote, and perpetuate national categories of identification, often contrary to the intentions of the Habsburg bureaucracy. The state did not create nations, but its classification of languages made available some ethnolinguistic identity categories that nationalists used to make political claims. The institutionalization of these categories also made them more relevant, especially as nationalist movements simultaneously worked toward the same goal. Yet identification with a nation did not follow an algorithmic logic, in the beginning of the twentieth century, sometimes earlier, various nationalisms could undoubtedly mobilize large numbers of people in Austria–Hungary, but people still had agency and nation-ness remained contingent and situational. PMID:29932174

Development of an Intelligent Monitoring and Control System for a Heterogeneous Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Afjeh, Abdollah A.; Lewandowski, Henry; Homer, Patrick T.; Schlichting, Richard D.

1996-01-01

The NASA Numerical Propulsion System Simulation (NPSS) project is exploring the use of computer simulation to facilitate the design of new jet engines. Several key issues raised in this research are being examined in an NPSS-related research project: zooming, monitoring and control, and support for heterogeneity. The design of a simulation executive that addresses each of these issues is described. In this work, the strategy of zooming, which allows codes that model at different levels of fidelity to be integrated within a single simulation, is applied to the fan component of a turbofan propulsion system. A prototype monitoring and control system has been designed for this simulation to support experimentation with expert system techniques for active control of the simulation. An interconnection system provides a transparent means of connecting the heterogeneous systems that comprise the prototype.

21 CFR 892.5840 - Radiation therapy simulation system.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Radiation therapy simulation system. 892.5840... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5840 Radiation therapy simulation system. (a) Identification. A radiation therapy simulation system is a fluoroscopic or radiographic x-ray...

21 CFR 892.5840 - Radiation therapy simulation system.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Radiation therapy simulation system. 892.5840... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5840 Radiation therapy simulation system. (a) Identification. A radiation therapy simulation system is a fluoroscopic or radiographic x-ray...

How to implement a new strategy without disrupting your organization.

PubMed

Kaplan, Robert S; Norton, David P

2006-03-01

Throughout most of modern busi ness history, corporations have attempted to unlock value by matching their structures to their strategies: Centralization by function. Decentralization by product category or geographic region. Matrix organizations that attempt both at once. Virtual organizations. Networked organizations. Velcro organizations. But none of these approaches has worked very well. Restructuring churn is expensive, and new structures often create new organizational problems that are as troublesome as the ones they try to solve. It takes time for employees to adapt to them, they create legacy systems that refuse to die, and a great deal of tacit knowledge gets lost in the process. Given the costs and difficulties involved in finding structural ways to unlock value, it's fair to raise the question: Is structural change the right tool for the job? The answer is usually no, Kaplan and Norton contend. It's far less disruptive to choose an organizational design that works without major conflicts and then design a customized strategic system to align that structure to the strategy. A management system based on the balanced scorecard framework is the best way to align strategy and structure, the authors suggest. Managers can use the tools of the framework to drive their unit's performance: strategy maps to define and communicate the company's value proposition and the scorecard to implement and monitor the strategy. In this article, the originators of the balanced scorecard describe how two hugely different organizations--DuPont and the Royal Canadian Mounted Police-used corporate scorecards and strategy maps organized around strategic themes to realize the enormous value that their portfolios of assets, people, and skills represented. As a result, they did not have to endure a painful series of changes that simply replaced one rigid structure with another.

Threat radar system simulations

NASA Astrophysics Data System (ADS)

Miller, L.

The capabilities, requirements, and goals of radar emitter simulators are discussed. Simulators are used to evaluate competing receiver designs, to quantify the performance envelope of a radar system, and to model the characteristics of a transmitted signal waveform. A database of candidate threat systems is developed and, in concert with intelligence data on a given weapons system, permits upgrading simulators to new projected threat capabilities. Four currently available simulation techniques are summarized, noting the usefulness of developing modular software for fast controlled-cost upgrades of simulation capabilities.

A Low Cost Microcomputer System for Process Dynamics and Control Simulations.

ERIC Educational Resources Information Center

Crowl, D. A.; Durisin, M. J.

1983-01-01

Discusses a video simulator microcomputer system used to provide real-time demonstrations to strengthen students' understanding of process dynamics and control. Also discusses hardware/software and simulations developed using the system. The four simulations model various configurations of a process liquid level tank system. (JN)

Simulation validation of the XV-15 tilt-rotor research aircraft

NASA Technical Reports Server (NTRS)

Ferguson, S. W.; Hanson, G. D.; Churchill, G. B.

1984-01-01

The results of a simulation validation program of the XV-15 tilt-rotor research aircraft are detailed, covering such simulation aspects as the mathematical model, visual system, motion system, cab aural system, cab control loader system, pilot perceptual fidelity, and generic tilt rotor applications. Simulation validation was performed for the hover, low-speed, and sideward flight modes, with consideration of the in-ground rotor effect. Several deficiencies of the mathematical model and the simulation systems were identified in the course of the simulation validation project, and some were corrected. It is noted that NASA's Vertical Motion Simulator used in the program is an excellent tool for tilt-rotor and rotorcraft design, development, and pilot training.

Method for simulating discontinuous physical systems

DOEpatents

Baty, Roy S.; Vaughn, Mark R.

2001-01-01

The mathematical foundations of conventional numerical simulation of physical systems provide no consistent description of the behavior of such systems when subjected to discontinuous physical influences. As a result, the numerical simulation of such problems requires ad hoc encoding of specific experimental results in order to address the behavior of such discontinuous physical systems. In the present invention, these foundations are replaced by a new combination of generalized function theory and nonstandard analysis. The result is a class of new approaches to the numerical simulation of physical systems which allows the accurate and well-behaved simulation of discontinuous and other difficult physical systems, as well as simpler physical systems. Applications of this new class of numerical simulation techniques to process control, robotics, and apparatus design are outlined.

Research and realization of key technology in HILS interactive system

NASA Astrophysics Data System (ADS)

Liu, Che; Lu, Huiming; Wang, Fankai

2018-03-01

This paper designed HILS (Hardware In the Loop Simulation) interactive system based on xPC platform . Through the interface between C++ and MATLAB engine, establish the seamless data connection between Simulink and interactive system, complete data interaction between system and Simulink, realize the function development of model configuration, parameter modification and off line simulation. We establish the data communication between host and target machine through TCP/IP protocol to realize the model download and real-time simulation. Use database to store simulation data, implement real-time simulation monitoring and simulation data management. Realize system function integration by Qt graphic interface library and dynamic link library. At last, take the typical control system as an example to verify the feasibility of HILS interactive system.

Interactive Web-based Floodplain Simulation System for Realistic Experiments of Flooding and Flood Damage

NASA Astrophysics Data System (ADS)

Demir, I.

2013-12-01

Recent developments in web technologies make it easy to manage and visualize large data sets with general public. Novel visualization techniques and dynamic user interfaces allow users to create realistic environments, and interact with data to gain insight from simulations and environmental observations. The floodplain simulation system is a web-based 3D interactive flood simulation environment to create real world flooding scenarios. The simulation systems provides a visually striking platform with realistic terrain information, and water simulation. Students can create and modify predefined scenarios, control environmental parameters, and evaluate flood mitigation techniques. The web-based simulation system provides an environment to children and adults learn about the flooding, flood damage, and effects of development and human activity in the floodplain. The system provides various scenarios customized to fit the age and education level of the users. This presentation provides an overview of the web-based flood simulation system, and demonstrates the capabilities of the system for various flooding and land use scenarios.

Novel high-fidelity realistic explosion damage simulation for urban environments

NASA Astrophysics Data System (ADS)

Liu, Xiaoqing; Yadegar, Jacob; Zhu, Youding; Raju, Chaitanya; Bhagavathula, Jaya

2010-04-01

Realistic building damage simulation has a significant impact in modern modeling and simulation systems especially in diverse panoply of military and civil applications where these simulation systems are widely used for personnel training, critical mission planning, disaster management, etc. Realistic building damage simulation should incorporate accurate physics-based explosion models, rubble generation, rubble flyout, and interactions between flying rubble and their surrounding entities. However, none of the existing building damage simulation systems sufficiently faithfully realize the criteria of realism required for effective military applications. In this paper, we present a novel physics-based high-fidelity and runtime efficient explosion simulation system to realistically simulate destruction to buildings. In the proposed system, a family of novel blast models is applied to accurately and realistically simulate explosions based on static and/or dynamic detonation conditions. The system also takes account of rubble pile formation and applies a generic and scalable multi-component based object representation to describe scene entities and highly scalable agent-subsumption architecture and scheduler to schedule clusters of sequential and parallel events. The proposed system utilizes a highly efficient and scalable tetrahedral decomposition approach to realistically simulate rubble formation. Experimental results demonstrate that the proposed system has the capability to realistically simulate rubble generation, rubble flyout and their primary and secondary impacts on surrounding objects including buildings, constructions, vehicles and pedestrians in clusters of sequential and parallel damage events.

Development of space simulation / net-laboratory system

NASA Astrophysics Data System (ADS)

Usui, H.; Matsumoto, H.; Ogino, T.; Fujimoto, M.; Omura, Y.; Okada, M.; Ueda, H. O.; Murata, T.; Kamide, Y.; Shinagawa, H.; Watanabe, S.; Machida, S.; Hada, T.

A research project for the development of space simulation / net-laboratory system was approved by Japan Science and Technology Corporation (JST) in the category of Research and Development for Applying Advanced Computational Science and Technology(ACT-JST) in 2000. This research project, which continues for three years, is a collaboration with an astrophysical simulation group as well as other space simulation groups which use MHD and hybrid models. In this project, we develop a proto type of unique simulation system which enables us to perform simulation runs by providing or selecting plasma parameters through Web-based interface on the internet. We are also developing an on-line database system for space simulation from which we will be able to search and extract various information such as simulation method and program, manuals, and typical simulation results in graphic or ascii format. This unique system will help the simulation beginners to start simulation study without much difficulty or effort, and contribute to the promotion of simulation studies in the STP field. In this presentation, we will report the overview and the current status of the project.

Cosimulation of embedded system using RTOS software simulator

NASA Astrophysics Data System (ADS)

Wang, Shihao; Duan, Zhigang; Liu, Mingye

2003-09-01

Embedded system design often employs co-simulation to verify system's function; one efficient verification tool of software is Instruction Set Simulator (ISS). As a full functional model of target CPU, ISS interprets instruction of embedded software step by step, which usually is time-consuming since it simulates at low-level. Hence ISS often becomes the bottleneck of co-simulation in a complicated system. In this paper, a new software verification tools, the RTOS software simulator (RSS) was presented. The mechanism of its operation was described in a full details. In RSS method, RTOS API is extended and hardware simulator driver is adopted to deal with data-exchange and synchronism between the two simulators.

Simulation of a Geiger-Mode Imaging LADAR System for Performance Assessment

PubMed Central

Kim, Seongjoon; Lee, Impyeong; Kwon, Yong Joon

2013-01-01

As LADAR systems applications gradually become more diverse, new types of systems are being developed. When developing new systems, simulation studies are an essential prerequisite. A simulator enables performance predictions and optimal system parameters at the design level, as well as providing sample data for developing and validating application algorithms. The purpose of the study is to propose a method for simulating a Geiger-mode imaging LADAR system. We develop simulation software to assess system performance and generate sample data for the applications. The simulation is based on three aspects of modeling—the geometry, radiometry and detection. The geometric model computes the ranges to the reflection points of the laser pulses. The radiometric model generates the return signals, including the noises. The detection model determines the flight times of the laser pulses based on the nature of the Geiger-mode detector. We generated sample data using the simulator with the system parameters and analyzed the detection performance by comparing the simulated points to the reference points. The proportion of the outliers in the simulated points reached 25.53%, indicating the need for efficient outlier elimination algorithms. In addition, the false alarm rate and dropout rate of the designed system were computed as 1.76% and 1.06%, respectively. PMID:23823970

Understanding Emergency Care Delivery Through Computer Simulation Modeling.

PubMed

Laker, Lauren F; Torabi, Elham; France, Daniel J; Froehle, Craig M; Goldlust, Eric J; Hoot, Nathan R; Kasaie, Parastu; Lyons, Michael S; Barg-Walkow, Laura H; Ward, Michael J; Wears, Robert L

2018-02-01

In 2017, Academic Emergency Medicine convened a consensus conference entitled, "Catalyzing System Change through Health Care Simulation: Systems, Competency, and Outcomes." This article, a product of the breakout session on "understanding complex interactions through systems modeling," explores the role that computer simulation modeling can and should play in research and development of emergency care delivery systems. This article discusses areas central to the use of computer simulation modeling in emergency care research. The four central approaches to computer simulation modeling are described (Monte Carlo simulation, system dynamics modeling, discrete-event simulation, and agent-based simulation), along with problems amenable to their use and relevant examples to emergency care. Also discussed is an introduction to available software modeling platforms and how to explore their use for research, along with a research agenda for computer simulation modeling. Through this article, our goal is to enhance adoption of computer simulation, a set of methods that hold great promise in addressing emergency care organization and design challenges. © 2017 by the Society for Academic Emergency Medicine.

A View on Future Building System Modeling and Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wetter, Michael

This chapter presents what a future environment for building system modeling and simulation may look like. As buildings continue to require increased performance and better comfort, their energy and control systems are becoming more integrated and complex. We therefore focus in this chapter on the modeling, simulation and analysis of building energy and control systems. Such systems can be classified as heterogeneous systems because they involve multiple domains, such as thermodynamics, fluid dynamics, heat and mass transfer, electrical systems, control systems and communication systems. Also, they typically involve multiple temporal and spatial scales, and their evolution can be described bymore » coupled differential equations, discrete equations and events. Modeling and simulating such systems requires a higher level of abstraction and modularisation to manage the increased complexity compared to what is used in today's building simulation programs. Therefore, the trend towards more integrated building systems is likely to be a driving force for changing the status quo of today's building simulation programs. Thischapter discusses evolving modeling requirements and outlines a path toward a future environment for modeling and simulation of heterogeneous building systems.A range of topics that would require many additional pages of discussion has been omitted. Examples include computational fluid dynamics for air and particle flow in and around buildings, people movement, daylight simulation, uncertainty propagation and optimisation methods for building design and controls. For different discussions and perspectives on the future of building modeling and simulation, we refer to Sahlin (2000), Augenbroe (2001) and Malkawi and Augenbroe (2004).« less

The Shuttle Mission Simulator computer generated imagery

NASA Technical Reports Server (NTRS)

Henderson, T. H.

1984-01-01

Equipment available in the primary training facility for the Space Transportation System (STS) flight crews includes the Fixed Base Simulator, the Motion Base Simulator, the Spacelab Simulator, and the Guidance and Navigation Simulator. The Shuttle Mission Simulator (SMS) consists of the Fixed Base Simulator and the Motion Base Simulator. The SMS utilizes four visual Computer Generated Image (CGI) systems. The Motion Base Simulator has a forward crew station with six-degrees of freedom motion simulation. Operation of the Spacelab Simulator is planned for the spring of 1983. The Guidance and Navigation Simulator went into operation in 1982. Aspects of orbital visual simulation are discussed, taking into account the earth scene, payload simulation, the generation and display of 1079 stars, the simulation of sun glare, and Reaction Control System jet firing plumes. Attention is also given to landing site visual simulation, and night launch and landing simulation.

Issues in visual support to real-time space system simulation solved in the Systems Engineering Simulator

NASA Technical Reports Server (NTRS)

Yuen, Vincent K.

1989-01-01

The Systems Engineering Simulator has addressed the major issues in providing visual data to its real-time man-in-the-loop simulations. Out-the-window views and CCTV views are provided by three scene systems to give the astronauts their real-world views. To expand the window coverage for the Space Station Freedom workstation a rotating optics system is used to provide the widest field of view possible. To provide video signals to as many viewpoints as possible, windows and CCTVs, with a limited amount of hardware, a video distribution system has been developed to time-share the video channels among viewpoints at the selection of the simulation users. These solutions have provided the visual simulation facility for real-time man-in-the-loop simulations for the NASA space program.

A Cryogenic Fluid System Simulation in Support of Integrated Systems Health Management

NASA Technical Reports Server (NTRS)

Barber, John P.; Johnston, Kyle B.; Daigle, Matthew

2013-01-01

Simulations serve as important tools throughout the design and operation of engineering systems. In the context of sys-tems health management, simulations serve many uses. For one, the underlying physical models can be used by model-based health management tools to develop diagnostic and prognostic models. These simulations should incorporate both nominal and faulty behavior with the ability to inject various faults into the system. Such simulations can there-fore be used for operator training, for both nominal and faulty situations, as well as for developing and prototyping health management algorithms. In this paper, we describe a methodology for building such simulations. We discuss the design decisions and tools used to build a simulation of a cryogenic fluid test bed, and how it serves as a core technology for systems health management development and maturation.

Simulating New Drop Test Vehicles and Test Techniques for the Orion CEV Parachute Assembly System

NASA Technical Reports Server (NTRS)

Morris, Aaron L.; Fraire, Usbaldo, Jr.; Bledsoe, Kristin J.; Ray, Eric; Moore, Jim W.; Olson, Leah M.

2011-01-01

The Crew Exploration Vehicle Parachute Assembly System (CPAS) project is engaged in a multi-year design and test campaign to qualify a parachute recovery system for human use on the Orion Spacecraft. Test and simulation techniques have evolved concurrently to keep up with the demands of a challenging and complex system. The primary simulations used for preflight predictions and post-test data reconstructions are Decelerator System Simulation (DSS), Decelerator System Simulation Application (DSSA), and Drop Test Vehicle Simulation (DTV-SIM). The goal of this paper is to provide a roadmap to future programs on the test technique challenges and obstacles involved in executing a large-scale, multi-year parachute test program. A focus on flight simulation modeling and correlation to test techniques executed to obtain parachute performance parameters are presented.

Analysis of the use of industrial control systems in simulators: state of the art and basic guidelines.

PubMed

Carrasco, Juan A; Dormido, Sebastián

2006-04-01

The use of industrial control systems in simulators facilitates the execution of engineering activities related with the installation and the optimization of the control systems in real plants. "Industrial control system" intends to be a valid term that would represent all the control systems which can be installed in an industrial plant, ranging from complex distributed control systems and SCADA packages to small single control devices. This paper summarizes the current alternatives for the development of simulators of industrial plants and presents an analysis of the process of integrating an industrial control system into a simulator, with the aim of helping in the installation of real control systems in simulators.

Dynamic Data-Driven UAV Network for Plume Characterization

DTIC Science & Technology

2016-05-23

data collection where simulations and measurements become a symbiotic feedback control system where simulations inform measurement locations and the...and measurements become a symbiotic feedback control system where simulations inform measurement locations and the measured data augments simulations...data analysis techniques with mobile sensor data collection where simulations and measurements become a symbiotic feedback control system where

System Simulation Modeling: A Case Study Illustration of the Model Development Life Cycle

Treesearch

Janice K. Wiedenbeck; D. Earl Kline

1994-01-01

Systems simulation modeling techniques offer a method of representing the individual elements of a manufacturing system and their interactions. By developing and experimenting with simulation models, one can obtain a better understanding of the overall physical system. Forest products industries are beginning to understand the importance of simulation modeling to help...

Design and implementation of laser target simulator in hardware-in-the-loop simulation system based on LabWindows/CVI and RTX

NASA Astrophysics Data System (ADS)

Tong, Qiujie; Wang, Qianqian; Li, Xiaoyang; Shan, Bin; Cui, Xuntai; Li, Chenyu; Peng, Zhong

2016-11-01

In order to satisfy the requirements of the real-time and generality, a laser target simulator in semi-physical simulation system based on RTX+LabWindows/CVI platform is proposed in this paper. Compared with the upper-lower computers simulation platform architecture used in the most of the real-time system now, this system has better maintainability and portability. This system runs on the Windows platform, using Windows RTX real-time extension subsystem to ensure the real-time performance of the system combining with the reflective memory network to complete some real-time tasks such as calculating the simulation model, transmitting the simulation data, and keeping real-time communication. The real-time tasks of simulation system run under the RTSS process. At the same time, we use the LabWindows/CVI to compile a graphical interface, and complete some non-real-time tasks in the process of simulation such as man-machine interaction, display and storage of the simulation data, which run under the Win32 process. Through the design of RTX shared memory and task scheduling algorithm, the data interaction between the real-time tasks process of RTSS and non-real-time tasks process of Win32 is completed. The experimental results show that this system has the strongly real-time performance, highly stability, and highly simulation accuracy. At the same time, it also has the good performance of human-computer interaction.

Reconstructing the ideal results of a perturbed analog quantum simulator

NASA Astrophysics Data System (ADS)

Schwenk, Iris; Reiner, Jan-Michael; Zanker, Sebastian; Tian, Lin; Leppäkangas, Juha; Marthaler, Michael

2018-04-01

Well-controlled quantum systems can potentially be used as quantum simulators. However, a quantum simulator is inevitably perturbed by coupling to additional degrees of freedom. This constitutes a major roadblock to useful quantum simulations. So far there are only limited means to understand the effect of perturbation on the results of quantum simulation. Here we present a method which, in certain circumstances, allows for the reconstruction of the ideal result from measurements on a perturbed quantum simulator. We consider extracting the value of the correlator 〈Ôi(t ) Ôj(0 ) 〉 from the simulated system, where Ôi are the operators which couple the system to its environment. The ideal correlator can be straightforwardly reconstructed by using statistical knowledge of the environment, if any n -time correlator of operators Ôi of the ideal system can be written as products of two-time correlators. We give an approach to verify the validity of this assumption experimentally by additional measurements on the perturbed quantum simulator. The proposed method can allow for reliable quantum simulations with systems subjected to environmental noise without adding an overhead to the quantum system.

A simulation framework for the CMS Track Trigger electronics

NASA Astrophysics Data System (ADS)

Amstutz, C.; Magazzù, G.; Weber, M.; Palla, F.

2015-03-01

A simulation framework has been developed to test and characterize algorithms, architectures and hardware implementations of the vastly complex CMS Track Trigger for the high luminosity upgrade of the CMS experiment at the Large Hadron Collider in Geneva. High-level SystemC models of all system components have been developed to simulate a portion of the track trigger. The simulation of the system components together with input data from physics simulations allows evaluating figures of merit, like delays or bandwidths, under realistic conditions. The use of SystemC for high-level modelling allows co-simulation with models developed in Hardware Description Languages, e.g. VHDL or Verilog. Therefore, the simulation framework can also be used as a test bench for digital modules developed for the final system.

Simulation and evaluation of the Sh-2F helicopter in a shipboard environment using the interchangeable cab system

NASA Technical Reports Server (NTRS)

Paulk, C. H., Jr.; Astill, D. L.; Donley, S. T.

1983-01-01

The operation of the SH-2F helicopter from the decks of small ships in adverse weather was simulated using a large amplitude vertical motion simulator, a wide angle computer generated imagery visual system, and an interchangeable cab (ICAB). The simulation facility, the mathematical programs, and the validation method used to ensure simulation fidelity are described. The results show the simulator to be a useful tool in simulating the ship-landing problem. Characteristics of the ICAB system and ways in which the simulation can be improved are presented.

Using numeric simulation in an online e-learning environment to teach functional physiological contexts.

PubMed

Christ, Andreas; Thews, Oliver

2016-04-01

Mathematical models are suitable to simulate complex biological processes by a set of non-linear differential equations. These simulation models can be used as an e-learning tool in medical education. However, in many cases these mathematical systems have to be treated numerically which is computationally intensive. The aim of the study was to develop a system for numerical simulation to be used in an online e-learning environment. In the software system the simulation is located on the server as a CGI application. The user (student) selects the boundary conditions for the simulation (e.g., properties of a simulated patient) on the browser. With these parameters the simulation on the server is started and the simulation result is re-transferred to the browser. With this system two examples of e-learning units were realized. The first one uses a multi-compartment model of the glucose-insulin control loop for the simulation of the plasma glucose level after a simulated meal or during diabetes (including treatment by subcutaneous insulin application). The second one simulates the ion transport leading to the resting and action potential in nerves. The student can vary parameters systematically to explore the biological behavior of the system. The described system is able to simulate complex biological processes and offers the possibility to use these models in an online e-learning environment. As far as the underlying principles can be described mathematically, this type of system can be applied to a broad spectrum of biomedical or natural scientific topics. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Using CONFIG for Simulation of Operation of Water Recovery Subsystems for Advanced Control Software Evaluation

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Flores, Luis; Fleming, Land; Throop, Daiv

2002-01-01

A hybrid discrete/continuous simulation tool, CONFIG, has been developed to support evaluation of the operability life support systems. CON FIG simulates operations scenarios in which flows and pressures change continuously while system reconfigurations occur as discrete events. In simulations, intelligent control software can interact dynamically with hardware system models. CONFIG simulations have been used to evaluate control software and intelligent agents for automating life support systems operations. A CON FIG model of an advanced biological water recovery system has been developed to interact with intelligent control software that is being used in a water system test at NASA Johnson Space Center

Block Oriented Simulation System (BOSS)

NASA Technical Reports Server (NTRS)

Ratcliffe, Jaimie

1988-01-01

Computer simulation is assuming greater importance as a flexible and expedient approach to modeling system and subsystem behavior. Simulation has played a key role in the growth of complex, multiple access space communications such as those used by the space shuttle and the TRW-built Tracking and Data Relay Satellites (TDRS). A powerful new simulator for use in designing and modeling the communication system of NASA's planned Space Station is being developed. Progress to date on the Block (Diagram) Oriented Simulation System (BOSS) is described.

Development of automation and robotics for space via computer graphic simulation methods

NASA Technical Reports Server (NTRS)

Fernandez, Ken

1988-01-01

A robot simulation system, has been developed to perform automation and robotics system design studies. The system uses a procedure-oriented solid modeling language to produce a model of the robotic mechanism. The simulator generates the kinematics, inverse kinematics, dynamics, control, and real-time graphic simulations needed to evaluate the performance of the model. Simulation examples are presented, including simulation of the Space Station and the design of telerobotics for the Orbital Maneuvering Vehicle.

G189A analytical simulation of the RITE Integrated Waste Management-Water System

NASA Technical Reports Server (NTRS)

Coggi, J. V.; Clonts, S. E.

1974-01-01

This paper discusses the computer simulation of the Integrated Waste Management-Water System Using Radioisotopes for Thermal Energy (RITE) and applications of the simulation. Variations in the system temperature and flows due to particular operating conditions and variations in equipment heating loads imposed on the system were investigated with the computer program. The results were assessed from the standpoint of the computed dynamic characteristics of the system and the potential applications of the simulation to system development and vehicle integration.

Ground Simulator Studies of the Effects of Valve Friction, Stick Friction, Flexibility, and Backwash on Power Control System Quality

NASA Technical Reports Server (NTRS)

Brown, B Porter

1958-01-01

Report presents results of tests made on a power control system by means of a ground simulator to determine the effects of various combinations of valve friction and stick friction on the ability of the pilot to control the system. Various friction conditions were simulated with a rigid control system, a flexible system, and a rigid system having some backlash. For the tests, the period and damping of the simulated airplane were held constant.

Advanced simulation model for IPM motor drive with considering phase voltage and stator inductance

NASA Astrophysics Data System (ADS)

Lee, Dong-Myung; Park, Hyun-Jong; Lee, Ju

2016-10-01

This paper proposes an advanced simulation model of driving system for Interior Permanent Magnet (IPM) BrushLess Direct Current (BLDC) motors driven by 120-degree conduction method (two-phase conduction method, TPCM) that is widely used for sensorless control of BLDC motors. BLDC motors can be classified as SPM (Surface mounted Permanent Magnet) and IPM motors. Simulation model of driving system with SPM motors is simple due to the constant stator inductance regardless of the rotor position. Simulation models of SPM motor driving system have been proposed in many researches. On the other hand, simulation models for IPM driving system by graphic-based simulation tool such as Matlab/Simulink have not been proposed. Simulation study about driving system of IPMs with TPCM is complex because stator inductances of IPM vary with the rotor position, as permanent magnets are embedded in the rotor. To develop sensorless scheme or improve control performance, development of control algorithm through simulation study is essential, and the simulation model that accurately reflects the characteristic of IPM is required. Therefore, this paper presents the advanced simulation model of IPM driving system, which takes into account the unique characteristic of IPM due to the position-dependent inductances. The validity of the proposed simulation model is validated by comparison to experimental and simulation results using IPM with TPCM control scheme.

Computer-generated forces in distributed interactive simulation

NASA Astrophysics Data System (ADS)

Petty, Mikel D.

1995-04-01

Distributed Interactive Simulation (DIS) is an architecture for building large-scale simulation models from a set of independent simulator nodes communicating via a common network protocol. DIS is most often used to create a simulated battlefield for military training. Computer Generated Forces (CGF) systems control large numbers of autonomous battlefield entities in a DIS simulation using computer equipment and software rather than humans in simulators. CGF entities serve as both enemy forces and supplemental friendly forces in a DIS exercise. Research into various aspects of CGF systems is ongoing. Several CGF systems have been implemented.

Use case driven approach to develop simulation model for PCS of APR1400 simulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong Wook, Kim; Hong Soo, Kim; Hyeon Tae, Kang

2006-07-01

The full-scope simulator is being developed to evaluate specific design feature and to support the iterative design and validation in the Man-Machine Interface System (MMIS) design of Advanced Power Reactor (APR) 1400. The simulator consists of process model, control logic model, and MMI for the APR1400 as well as the Power Control System (PCS). In this paper, a use case driven approach is proposed to develop a simulation model for PCS. In this approach, a system is considered from the point of view of its users. User's view of the system is based on interactions with the system and themore » resultant responses. In use case driven approach, we initially consider the system as a black box and look at its interactions with the users. From these interactions, use cases of the system are identified. Then the system is modeled using these use cases as functions. Lower levels expand the functionalities of each of these use cases. Hence, starting from the topmost level view of the system, we proceeded down to the lowest level (the internal view of the system). The model of the system thus developed is use case driven. This paper will introduce the functionality of the PCS simulation model, including a requirement analysis based on use case and the validation result of development of PCS model. The PCS simulation model using use case will be first used during the full-scope simulator development for nuclear power plant and will be supplied to Shin-Kori 3 and 4 plant. The use case based simulation model development can be useful for the design and implementation of simulation models. (authors)« less

Predicting System Accidents with Model Analysis During Hybrid Simulation

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Fleming, Land D.; Throop, David R.

2002-01-01

Standard discrete event simulation is commonly used to identify system bottlenecks and starving and blocking conditions in resources and services. The CONFIG hybrid discrete/continuous simulation tool can simulate such conditions in combination with inputs external to the simulation. This provides a means for evaluating the vulnerability to system accidents of a system's design, operating procedures, and control software. System accidents are brought about by complex unexpected interactions among multiple system failures , faulty or misleading sensor data, and inappropriate responses of human operators or software. The flows of resource and product materials play a central role in the hazardous situations that may arise in fluid transport and processing systems. We describe the capabilities of CONFIG for simulation-time linear circuit analysis of fluid flows in the context of model-based hazard analysis. We focus on how CONFIG simulates the static stresses in systems of flow. Unlike other flow-related properties, static stresses (or static potentials) cannot be represented by a set of state equations. The distribution of static stresses is dependent on the specific history of operations performed on a system. We discuss the use of this type of information in hazard analysis of system designs.

Open-source framework for power system transmission and distribution dynamics co-simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Renke; Fan, Rui; Daily, Jeff

The promise of the smart grid entails more interactions between the transmission and distribution networks, and there is an immediate need for tools to provide the comprehensive modelling and simulation required to integrate operations at both transmission and distribution levels. Existing electromagnetic transient simulators can perform simulations with integration of transmission and distribution systems, but the computational burden is high for large-scale system analysis. For transient stability analysis, currently there are only separate tools for simulating transient dynamics of the transmission and distribution systems. In this paper, we introduce an open source co-simulation framework “Framework for Network Co-Simulation” (FNCS), togethermore » with the decoupled simulation approach that links existing transmission and distribution dynamic simulators through FNCS. FNCS is a middleware interface and framework that manages the interaction and synchronization of the transmission and distribution simulators. Preliminary testing results show the validity and capability of the proposed open-source co-simulation framework and the decoupled co-simulation methodology.« less

Interactive Learning Environment: Web-based Virtual Hydrological Simulation System using Augmented and Immersive Reality

NASA Astrophysics Data System (ADS)

Demir, I.

2014-12-01

Recent developments in internet technologies make it possible to manage and visualize large data on the web. Novel visualization techniques and interactive user interfaces allow users to create realistic environments, and interact with data to gain insight from simulations and environmental observations. The hydrological simulation system is a web-based 3D interactive learning environment for teaching hydrological processes and concepts. The simulation systems provides a visually striking platform with realistic terrain information, and water simulation. Students can create or load predefined scenarios, control environmental parameters, and evaluate environmental mitigation alternatives. The web-based simulation system provides an environment for students to learn about the hydrological processes (e.g. flooding and flood damage), and effects of development and human activity in the floodplain. The system utilizes latest web technologies and graphics processing unit (GPU) for water simulation and object collisions on the terrain. Users can access the system in three visualization modes including virtual reality, augmented reality, and immersive reality using heads-up display. The system provides various scenarios customized to fit the age and education level of various users. This presentation provides an overview of the web-based flood simulation system, and demonstrates the capabilities of the system for various visualization and interaction modes.

75 FR 65614 - Availability for Non-Exclusive or Partially-Exclusive Licensing of Invention Concerning...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-26

... Licensing of Invention Concerning Obstetrics Simulation and Training Method System AGENCY: Department of the... invention set forth in U.S. Patent Application Serial No. 12/670,250, entitled ``Obstetrics Simulation and... simulation system. An embodiment of the invention provides an obstetrics simulation system compromising an...

14 CFR Appendix E to Part 60 - Qualification Performance Standards for Quality Management Systems for Flight Simulation Training...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Quality Management Systems for Flight Simulation Training Devices E Appendix E to Part 60 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION...—Qualification Performance Standards for Quality Management Systems for Flight Simulation Training Devices Begin...

DDS: The Dental Diagnostic Simulation System.

ERIC Educational Resources Information Center

Tira, Daniel E.

The Dental Diagnostic Simulation (DDS) System provides an alternative to simulation systems which represent diagnostic case studies of relatively limited scope. It may be used to generate simulated case studies in all of the dental specialty areas with case materials progressing through the gamut of the diagnostic process. The generation of a…

Simulation of a synergistic six-post motion system on the flight simulator for advanced aircraft at NASA-Ames

NASA Technical Reports Server (NTRS)

Bose, S. C.; Parris, B. L.

1977-01-01

Motion system drive philosophy and corresponding real-time software have been developed for the purpose of simulating the characteristics of a typical synergistic Six-Post Motion System (SPMS) on the Flight Simulator for Advanced Aircraft (FSAA) at NASA-Ames which is a non-synergistic motion system. This paper gives a brief description of these two types of motion systems and the general methods of producing motion cues of the FSAA. An actuator extension transformation which allows the simulation of a typical SPMS by appropriate drive washout and variable position limiting is described.

A system for automatic evaluation of simulation software

NASA Technical Reports Server (NTRS)

Ryan, J. P.; Hodges, B. C.

1976-01-01

Within the field of computer software, simulation and verification are complementary processes. Simulation methods can be used to verify software by performing variable range analysis. More general verification procedures, such as those described in this paper, can be implicitly, viewed as attempts at modeling the end-product software. From software requirement methodology, each component of the verification system has some element of simulation to it. Conversely, general verification procedures can be used to analyze simulation software. A dynamic analyzer is described which can be used to obtain properly scaled variables for an analog simulation, which is first digitally simulated. In a similar way, it is thought that the other system components and indeed the whole system itself have the potential of being effectively used in a simulation environment.

Development of a Prototype Simulation Executive with Zooming in the Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Afjeh, Abdollah A.

1995-01-01

A major difficulty in designing aeropropulsion systems is that of identifying and understanding the interactions between the separate engine components and disciplines (e.g., fluid mechanics, structural mechanics, heat transfer, material properties, etc.). The traditional analysis approach is to decompose the system into separate components with the interaction between components being evaluated by the application of each of the single disciplines in a sequential manner. Here, one discipline uses information from the calculation of another discipline to determine the effects of component coupling. This approach, however, may not properly identify the consequences of these effects during the design phase, leaving the interactions to be discovered and evaluated during engine testing. This contributes to the time and cost of developing new propulsion systems as, typically, several design-build-test cycles are needed to fully identify multidisciplinary effects and reach the desired system performance. The alternative to sequential isolated component analysis is to use multidisciplinary coupling at a more fundamental level. This approach has been made more plausible due to recent advancements in computation simulation along with application of concurrent engineering concepts. Computer simulation systems designed to provide an environment which is capable of integrating the various disciplines into a single simulation system have been proposed and are currently being developed. One such system is being developed by the Numerical Propulsion System Simulation (NPSS) project. The NPSS project, being developed at the Interdisciplinary Technology Office at the NASA Lewis Research Center is a 'numerical test cell' designed to provide for comprehensive computational design and analysis of aerospace propulsion systems. It will provide multi-disciplinary analyses on a variety of computational platforms, and a user-interface consisting of expert systems, data base management and visualization tools, to allow the designer to investigate the complex interactions inherent in these systems. An interactive programming software system, known as the Application Visualization System (AVS), was utilized for the development of the propulsion system simulation. The modularity of this system provides the ability to couple propulsion system components, as well as disciplines, and provides for the ability to integrate existing, well established analysis codes into the overall system simulation. This feature allows the user to customize the simulation model by inserting desired analysis codes. The prototypical simulation environment for multidisciplinary analysis, called Turbofan Engine System Simulation (TESS), which incorporates many of the characteristics of the simulation environment proposed herein, is detailed.

Distributed Engine Control Empirical/Analytical Verification Tools

NASA Technical Reports Server (NTRS)

DeCastro, Jonathan; Hettler, Eric; Yedavalli, Rama; Mitra, Sayan

2013-01-01

NASA's vision for an intelligent engine will be realized with the development of a truly distributed control system featuring highly reliable, modular, and dependable components capable of both surviving the harsh engine operating environment and decentralized functionality. A set of control system verification tools was developed and applied to a C-MAPSS40K engine model, and metrics were established to assess the stability and performance of these control systems on the same platform. A software tool was developed that allows designers to assemble easily a distributed control system in software and immediately assess the overall impacts of the system on the target (simulated) platform, allowing control system designers to converge rapidly on acceptable architectures with consideration to all required hardware elements. The software developed in this program will be installed on a distributed hardware-in-the-loop (DHIL) simulation tool to assist NASA and the Distributed Engine Control Working Group (DECWG) in integrating DCS (distributed engine control systems) components onto existing and next-generation engines.The distributed engine control simulator blockset for MATLAB/Simulink and hardware simulator provides the capability to simulate virtual subcomponents, as well as swap actual subcomponents for hardware-in-the-loop (HIL) analysis. Subcomponents can be the communication network, smart sensor or actuator nodes, or a centralized control system. The distributed engine control blockset for MATLAB/Simulink is a software development tool. The software includes an engine simulation, a communication network simulation, control algorithms, and analysis algorithms set up in a modular environment for rapid simulation of different network architectures; the hardware consists of an embedded device running parts of the CMAPSS engine simulator and controlled through Simulink. The distributed engine control simulation, evaluation, and analysis technology provides unique capabilities to study the effects of a given change to the control system in the context of the distributed paradigm. The simulation tool can support treatment of all components within the control system, both virtual and real; these include communication data network, smart sensor and actuator nodes, centralized control system (FADEC full authority digital engine control), and the aircraft engine itself. The DECsim tool can allow simulation-based prototyping of control laws, control architectures, and decentralization strategies before hardware is integrated into the system. With the configuration specified, the simulator allows a variety of key factors to be systematically assessed. Such factors include control system performance, reliability, weight, and bandwidth utilization.

Instrumented Architectural Simulation System

NASA Technical Reports Server (NTRS)

Delagi, B. A.; Saraiya, N.; Nishimura, S.; Byrd, G.

1987-01-01

Simulation of systems at an architectural level can offer an effective way to study critical design choices if (1) the performance of the simulator is adequate to examine designs executing significant code bodies, not just toy problems or small application fragements, (2) the details of the simulation include the critical details of the design, (3) the view of the design presented by the simulator instrumentation leads to useful insights on the problems with the design, and (4) there is enough flexibility in the simulation system so that the asking of unplanned questions is not suppressed by the weight of the mechanics involved in making changes either in the design or its measurement. A simulation system with these goals is described together with the approach to its implementation. Its application to the study of a particular class of multiprocessor hardware system architectures is illustrated.

DKIST Adaptive Optics System: Simulation Results

NASA Astrophysics Data System (ADS)

Marino, Jose; Schmidt, Dirk

2016-05-01

The 4 m class Daniel K. Inouye Solar Telescope (DKIST), currently under construction, will be equipped with an ultra high order solar adaptive optics (AO) system. The requirements and capabilities of such a solar AO system are beyond those of any other solar AO system currently in operation. We must rely on solar AO simulations to estimate and quantify its performance.We present performance estimation results of the DKIST AO system obtained with a new solar AO simulation tool. This simulation tool is a flexible and fast end-to-end solar AO simulator which produces accurate solar AO simulations while taking advantage of current multi-core computer technology. It relies on full imaging simulations of the extended field Shack-Hartmann wavefront sensor (WFS), which directly includes important secondary effects such as field dependent distortions and varying contrast of the WFS sub-aperture images.

Simulating storage part of application with Simgrid

NASA Astrophysics Data System (ADS)

Wang, Cong

2017-10-01

Design of a file system simulation and visualization system, using simgrid API and visualization techniques to help users understanding and improving the file system portion of their application. The core of the simulator is the API provided by simgrid, cluefs tracks and catches the procedure of the I/O operation. Run the simulator simulating this application to generate the output visualization file, which can visualize the I/O action proportion and time series. Users can also change the parameters in the configuration file to change the parameters of the storage system such as reading and writing bandwidth, users can also adjust the storage strategy, test the performance, getting reference to be much easier to optimize the storage system. We have tested all the aspects of the simulator, the results suggest that the simulator performance can be believable.

Integrating Soft Set Theory and Fuzzy Linguistic Model to Evaluate the Performance of Training Simulation Systems

PubMed Central

Chang, Kuei-Hu; Chang, Yung-Chia; Chain, Kai; Chung, Hsiang-Yu

2016-01-01

The advancement of high technologies and the arrival of the information age have caused changes to the modern warfare. The military forces of many countries have replaced partially real training drills with training simulation systems to achieve combat readiness. However, considerable types of training simulation systems are used in military settings. In addition, differences in system set up time, functions, the environment, and the competency of system operators, as well as incomplete information have made it difficult to evaluate the performance of training simulation systems. To address the aforementioned problems, this study integrated analytic hierarchy process, soft set theory, and the fuzzy linguistic representation model to evaluate the performance of various training simulation systems. Furthermore, importance–performance analysis was adopted to examine the influence of saving costs and training safety of training simulation systems. The findings of this study are expected to facilitate applying military training simulation systems, avoiding wasting of resources (e.g., low utility and idle time), and providing data for subsequent applications and analysis. To verify the method proposed in this study, the numerical examples of the performance evaluation of training simulation systems were adopted and compared with the numerical results of an AHP and a novel AHP-based ranking technique. The results verified that not only could expert-provided questionnaire information be fully considered to lower the repetition rate of performance ranking, but a two-dimensional graph could also be used to help administrators allocate limited resources, thereby enhancing the investment benefits and training effectiveness of a training simulation system. PMID:27598390

Extensible Adaptable Simulation Systems: Supporting Multiple Fidelity Simulations in a Common Environment

NASA Technical Reports Server (NTRS)

McLaughlin, Brian J.; Barrett, Larry K.

2012-01-01

Common practice in the development of simulation systems is meeting all user requirements within a single instantiation. The Joint Polar Satellite System (JPSS) presents a unique challenge to establish a simulation environment that meets the needs of a diverse user community while also spanning a multi-mission environment over decades of operation. In response, the JPSS Flight Vehicle Test Suite (FVTS) is architected with an extensible infrastructure that supports the operation of multiple observatory simulations for a single mission and multiple mission within a common system perimeter. For the JPSS-1 satellite, multiple fidelity flight observatory simulations are necessary to support the distinct user communities consisting of the Common Ground System development team, the Common Ground System Integration & Test team, and the Mission Rehearsal Team/Mission Operations Team. These key requirements present several challenges to FVTS development. First, the FVTS must ensure all critical user requirements are satisfied by at least one fidelity instance of the observatory simulation. Second, the FVTS must allow for tailoring of the system instances to function in diverse operational environments from the High-security operations environment at NOAA Satellite Operations Facility (NSOF) to the ground system factory floor. Finally, the FVTS must provide the ability to execute sustaining engineering activities on a subset of the system without impacting system availability to parallel users. The FVTS approach of allowing for multiple fidelity copies of observatory simulations represents a unique concept in simulator capability development and corresponds to the JPSS Ground System goals of establishing a capability that is flexible, extensible, and adaptable.

Integrating Soft Set Theory and Fuzzy Linguistic Model to Evaluate the Performance of Training Simulation Systems.

PubMed

Chang, Kuei-Hu; Chang, Yung-Chia; Chain, Kai; Chung, Hsiang-Yu

2016-01-01

The advancement of high technologies and the arrival of the information age have caused changes to the modern warfare. The military forces of many countries have replaced partially real training drills with training simulation systems to achieve combat readiness. However, considerable types of training simulation systems are used in military settings. In addition, differences in system set up time, functions, the environment, and the competency of system operators, as well as incomplete information have made it difficult to evaluate the performance of training simulation systems. To address the aforementioned problems, this study integrated analytic hierarchy process, soft set theory, and the fuzzy linguistic representation model to evaluate the performance of various training simulation systems. Furthermore, importance-performance analysis was adopted to examine the influence of saving costs and training safety of training simulation systems. The findings of this study are expected to facilitate applying military training simulation systems, avoiding wasting of resources (e.g., low utility and idle time), and providing data for subsequent applications and analysis. To verify the method proposed in this study, the numerical examples of the performance evaluation of training simulation systems were adopted and compared with the numerical results of an AHP and a novel AHP-based ranking technique. The results verified that not only could expert-provided questionnaire information be fully considered to lower the repetition rate of performance ranking, but a two-dimensional graph could also be used to help administrators allocate limited resources, thereby enhancing the investment benefits and training effectiveness of a training simulation system.

Knowledge-based simulation for aerospace systems

NASA Technical Reports Server (NTRS)

Will, Ralph W.; Sliwa, Nancy E.; Harrison, F. Wallace, Jr.

1988-01-01

Knowledge-based techniques, which offer many features that are desirable in the simulation and development of aerospace vehicle operations, exhibit many similarities to traditional simulation packages. The eventual solution of these systems' current symbolic processing/numeric processing interface problem will lead to continuous and discrete-event simulation capabilities in a single language, such as TS-PROLOG. Qualitative, totally-symbolic simulation methods are noted to possess several intrinsic characteristics that are especially revelatory of the system being simulated, and capable of insuring that all possible behaviors are considered.

``Losing the Dark:'' A Planetarium PSA about Light Pollution

NASA Astrophysics Data System (ADS)

Productions, L. N.; Walker, D. C.

2013-04-01

Losing the Dark is a PSA video being created for fulldome theaters by Loch Ness Productions under the direction of the International Dark Sky Association Education Committee headed by Dr. Constance Walker of the National Optical Astronomy Observatories. It explains the problems with light pollution, its effects on life, and three ways in which people can implement “wise lighting” practices to mitigate light pollution. The show is also being produced in a flat-screen HD format for use in classical planetarium and non-dome theaters, for presentations by IDA speakers when addressing planning boards, etc. and will be posted on the IDA and other web sites. The final length is six minutes for both versions. Funding has been provided by The International Planetarium Society and the International Dark-Sky Association.

Long-term memory for the emotional gist and the emotional essence of an experience.

PubMed

Safer, Martin A; Breslin, Carolyn W; Boesch, Richard P; Cerqueira, Renata

2007-11-01

We investigated accuracy in recalling past emotional behaviours and emotionality. Male couples discussed the history of their relationship, and coders rated the extent to which each partner engaged in behaviours such as complimenting or criticising. These ratings were combined into dimensions representing the deeper, emotional essence of that partner's discussion (expressions of We-ness, Fondness, Negativity, and Disappointment). Four years later, participants accurately recalled some of their own and some of their partner's emotional gist-level behaviours, but their answers indicated that they also remembered the emotional essence of the conversation. We conclude that individuals can retain the emotional essence of an experience for a long time, and that they may use this memory to infer, in part, gist-level details of the experience.

The interrelationships of wellness, public health, and chiropractic

PubMed Central

Hawk, Cheryl

2005-01-01

Abstract Objectives To explicate the relationships among the definitions and practices of chiropractic, wellness and public health and to make recommendations for strengthening these relationships. Background Public health-related topics comprise less than 2% of chiropractic coursework at most chiropractic colleges, and few connections currently exist between chiropractic and public health practice. The concept of well-ness is common to both, and might serve to bridge the gap between the individual health services provided by chiropractors and the community health services provided by public health agencies. Conclusion It is time for chiropractic to join the public health movement to improve the health and promote wellness not just in their patient populations, but in their communities, and demonstrate their commitment to patient wellness by integrating their efforts with the healthcare mainstream. PMID:19674661

Satellite observed thermodynamics during FGGE

NASA Technical Reports Server (NTRS)

Smith, W. L.

1985-01-01

During the First Global Atmospheric Research Program (GARP) Global Experiment (FGGE), determinations of temperature and moisture were made from TIROS-N and NOAA-6 satellite infrared and microwave sounding radiance measurements. The data were processed by two methods differing principally in their horizontal resolution. At the National Earth Satellite Service (NESS) in Washington, D.C., the data were produced operationally with a horizontal resolution of 250 km for inclusion in the FGGE Level IIb data sets for application to large-scale numerical analysis and prediction models. High horizontal resolution (75 km) sounding data sets were produced using man-machine interactive methods for the special observing periods of FGGE at the NASA/Goddard Space Flight Center and archived as supplementary Level IIb. The procedures used for sounding retrieval and the characteristics and quality of these thermodynamic observations are given.

System analysis for the Huntsville Operational Support Center distributed computer system

NASA Technical Reports Server (NTRS)

Ingels, F. M.; Mauldin, J.

1984-01-01

The Huntsville Operations Support Center (HOSC) is a distributed computer system used to provide real time data acquisition, analysis and display during NASA space missions and to perform simulation and study activities during non-mission times. The primary purpose is to provide a HOSC system simulation model that is used to investigate the effects of various HOSC system configurations. Such a model would be valuable in planning the future growth of HOSC and in ascertaining the effects of data rate variations, update table broadcasting and smart display terminal data requirements on the HOSC HYPERchannel network system. A simulation model was developed in PASCAL and results of the simulation model for various system configuraions were obtained. A tutorial of the model is presented and the results of simulation runs are presented. Some very high data rate situations were simulated to observe the effects of the HYPERchannel switch over from contention to priority mode under high channel loading.

Analyzing Robotic Kinematics Via Computed Simulations

NASA Technical Reports Server (NTRS)

Carnahan, Timothy M.

1992-01-01

Computing system assists in evaluation of kinematics of conceptual robot. Displays positions and motions of robotic manipulator within work cell. Also displays interactions between robotic manipulator and other objects. Results of simulation displayed on graphical computer workstation. System includes both off-the-shelf software originally developed for automotive industry and specially developed software. Simulation system also used to design human-equivalent hand, to model optical train in infrared system, and to develop graphical interface for teleoperator simulation system.

Virtual Observation System for Earth System Model: An Application to ACME Land Model Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Dali; Yuan, Fengming; Hernandez, Benjamin

Investigating and evaluating physical-chemical-biological processes within an Earth system model (EMS) can be very challenging due to the complexity of both model design and software implementation. A virtual observation system (VOS) is presented to enable interactive observation of these processes during system simulation. Based on advance computing technologies, such as compiler-based software analysis, automatic code instrumentation, and high-performance data transport, the VOS provides run-time observation capability, in-situ data analytics for Earth system model simulation, model behavior adjustment opportunities through simulation steering. A VOS for a terrestrial land model simulation within the Accelerated Climate Modeling for Energy model is also presentedmore » to demonstrate the implementation details and system innovations.« less

Virtual Observation System for Earth System Model: An Application to ACME Land Model Simulations

DOE PAGES

Wang, Dali; Yuan, Fengming; Hernandez, Benjamin; ...

2017-01-01

Investigating and evaluating physical-chemical-biological processes within an Earth system model (EMS) can be very challenging due to the complexity of both model design and software implementation. A virtual observation system (VOS) is presented to enable interactive observation of these processes during system simulation. Based on advance computing technologies, such as compiler-based software analysis, automatic code instrumentation, and high-performance data transport, the VOS provides run-time observation capability, in-situ data analytics for Earth system model simulation, model behavior adjustment opportunities through simulation steering. A VOS for a terrestrial land model simulation within the Accelerated Climate Modeling for Energy model is also presentedmore » to demonstrate the implementation details and system innovations.« less

Operating system for a real-time multiprocessor propulsion system simulator

NASA Technical Reports Server (NTRS)

Cole, G. L.

1984-01-01

The success of the Real Time Multiprocessor Operating System (RTMPOS) in the development and evaluation of experimental hardware and software systems for real time interactive simulation of air breathing propulsion systems was evaluated. The Real Time Multiprocessor Operating System (RTMPOS) provides the user with a versatile, interactive means for loading, running, debugging and obtaining results from a multiprocessor based simulator. A front end processor (FEP) serves as the simulator controller and interface between the user and the simulator. These functions are facilitated by the RTMPOS which resides on the FEP. The RTMPOS acts in conjunction with the FEP's manufacturer supplied disk operating system that provides typical utilities like an assembler, linkage editor, text editor, file handling services, etc. Once a simulation is formulated, the RTMPOS provides for engineering level, run time operations such as loading, modifying and specifying computation flow of programs, simulator mode control, data handling and run time monitoring. Run time monitoring is a powerful feature of RTMPOS that allows the user to record all actions taken during a simulation session and to receive advisories from the simulator via the FEP. The RTMPOS is programmed mainly in PASCAL along with some assembly language routines. The RTMPOS software is easily modified to be applicable to hardware from different manufacturers.

Application of control theory to dynamic systems simulation

NASA Technical Reports Server (NTRS)

Auslander, D. M.; Spear, R. C.; Young, G. E.

1982-01-01

The application of control theory is applied to dynamic systems simulation. Theory and methodology applicable to controlled ecological life support systems are considered. Spatial effects on system stability, design of control systems with uncertain parameters, and an interactive computing language (PARASOL-II) designed for dynamic system simulation, report quality graphics, data acquisition, and simple real time control are discussed.

21 CFR 1020.32 - Fluoroscopic equipment.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Radiation therapy simulation systems shall be exempt from this requirement provided the systems are intended... 10, 2006, other than radiation therapy simulation systems, the following applies: (A) Neither the... fluoroscopic equipment manufactured on or after June 10, 2006, other than radiation therapy simulation systems...

Simulator for concurrent processing data flow architectures

NASA Technical Reports Server (NTRS)

Malekpour, Mahyar R.; Stoughton, John W.; Mielke, Roland R.

1992-01-01

A software simulator capability of simulating execution of an algorithm graph on a given system under the Algorithm to Architecture Mapping Model (ATAMM) rules is presented. ATAMM is capable of modeling the execution of large-grained algorithms on distributed data flow architectures. Investigating the behavior and determining the performance of an ATAMM based system requires the aid of software tools. The ATAMM Simulator presented is capable of determining the performance of a system without having to build a hardware prototype. Case studies are performed on four algorithms to demonstrate the capabilities of the ATAMM Simulator. Simulated results are shown to be comparable to the experimental results of the Advanced Development Model System.

Look-ahead Dynamic Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

2015-10-20

Look-ahead dynamic simulation software system incorporates the high performance parallel computing technologies, significantly reduces the solution time for each transient simulation case, and brings the dynamic simulation analysis into on-line applications to enable more transparency for better reliability and asset utilization. It takes the snapshot of the current power grid status, functions in parallel computing the system dynamic simulation, and outputs the transient response of the power system in real time.

Dynamic system simulation of small satellite projects

NASA Astrophysics Data System (ADS)

Raif, Matthias; Walter, Ulrich; Bouwmeester, Jasper

2010-11-01

A prerequisite to accomplish a system simulation is to have a system model holding all necessary project information in a centralized repository that can be accessed and edited by all parties involved. At the Institute of Astronautics of the Technische Universitaet Muenchen a modular approach for modeling and dynamic simulation of satellite systems has been developed called dynamic system simulation (DySyS). DySyS is based on the platform independent description language SysML to model a small satellite project with respect to the system composition and dynamic behavior. A library of specific building blocks and possible relations between these blocks have been developed. From this library a system model of the satellite of interest can be created. A mapping into a C++ simulation allows the creation of an executable system model with which simulations are performed to observe the dynamic behavior of the satellite. In this paper DySyS is used to model and simulate the dynamic behavior of small satellites, because small satellite projects can act as a precursor to demonstrate the feasibility of a system model since they are less complex compared to a large scale satellite project.

Longitudinal train dynamics: an overview

NASA Astrophysics Data System (ADS)

Wu, Qing; Spiryagin, Maksym; Cole, Colin

2016-12-01

This paper discusses the evolution of longitudinal train dynamics (LTD) simulations, which covers numerical solvers, vehicle connection systems, air brake systems, wagon dumper systems and locomotives, resistance forces and gravitational components, vehicle in-train instabilities, and computing schemes. A number of potential research topics are suggested, such as modelling of friction, polymer, and transition characteristics for vehicle connection simulations, studies of wagon dumping operations, proper modelling of vehicle in-train instabilities, and computing schemes for LTD simulations. Evidence shows that LTD simulations have evolved with computing capabilities. Currently, advanced component models that directly describe the working principles of the operation of air brake systems, vehicle connection systems, and traction systems are available. Parallel computing is a good solution to combine and simulate all these advanced models. Parallel computing can also be used to conduct three-dimensional long train dynamics simulations.

An Interactive Teaching System for Bond Graph Modeling and Simulation in Bioengineering

ERIC Educational Resources Information Center

Roman, Monica; Popescu, Dorin; Selisteanu, Dan

2013-01-01

The objective of the present work was to implement a teaching system useful in modeling and simulation of biotechnological processes. The interactive system is based on applications developed using 20-sim modeling and simulation software environment. A procedure for the simulation of bioprocesses modeled by bond graphs is proposed and simulators…

Strategy and gaps for modeling, simulation, and control of hybrid systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rabiti, Cristian; Garcia, Humberto E.; Hovsapian, Rob

2015-04-01

The purpose of this report is to establish a strategy for modeling and simulation of candidate hybrid energy systems. Modeling and simulation is necessary to design, evaluate, and optimize the system technical and economic performance. Accordingly, this report first establishes the simulation requirements to analysis candidate hybrid systems. Simulation fidelity levels are established based on the temporal scale, real and synthetic data availability or needs, solution accuracy, and output parameters needed to evaluate case-specific figures of merit. Accordingly, the associated computational and co-simulation resources needed are established; including physical models when needed, code assembly and integrated solutions platforms, mathematical solvers,more » and data processing. This report first attempts to describe the figures of merit, systems requirements, and constraints that are necessary and sufficient to characterize the grid and hybrid systems behavior and market interactions. Loss of Load Probability (LOLP) and effective cost of Effective Cost of Energy (ECE), as opposed to the standard Levelized Cost of Electricty (LCOE), are introduced as technical and economical indices for integrated energy system evaluations. Financial assessment methods are subsequently introduced for evaluation of non-traditional, hybrid energy systems. Algorithms for coupled and iterative evaluation of the technical and economic performance are subsequently discussed. This report further defines modeling objectives, computational tools, solution approaches, and real-time data collection and processing (in some cases using real test units) that will be required to model, co-simulate, and optimize; (a) an energy system components (e.g., power generation unit, chemical process, electricity management unit), (b) system domains (e.g., thermal, electrical or chemical energy generation, conversion, and transport), and (c) systems control modules. Co-simulation of complex, tightly coupled, dynamic energy systems requires multiple simulation tools, potentially developed in several programming languages and resolved on separate time scales. Whereas further investigation and development of hybrid concepts will provide a more complete understanding of the joint computational and physical modeling needs, this report highlights areas in which co-simulation capabilities are warranted. The current development status, quality assurance, availability and maintainability of simulation tools that are currently available for hybrid systems modeling is presented. Existing gaps in the modeling and simulation toolsets and development needs are subsequently discussed. This effort will feed into a broader Roadmap activity for designing, developing, and demonstrating hybrid energy systems.« less

A Unique Software System For Simulation-to-Flight Research

NASA Technical Reports Server (NTRS)

Chung, Victoria I.; Hutchinson, Brian K.

2001-01-01

"Simulation-to-Flight" is a research development concept to reduce costs and increase testing efficiency of future major aeronautical research efforts at NASA. The simulation-to-flight concept is achieved by using common software and hardware, procedures, and processes for both piloted-simulation and flight testing. This concept was applied to the design and development of two full-size transport simulators, a research system installed on a NASA B-757 airplane, and two supporting laboratories. This paper describes the software system that supports the simulation-to-flight facilities. Examples of various simulation-to-flight experimental applications were also provided.

Simulating neural systems with Xyce.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schiek, Richard Louis; Thornquist, Heidi K.; Mei, Ting

2012-12-01

Sandias parallel circuit simulator, Xyce, can address large scale neuron simulations in a new way extending the range within which one can perform high-fidelity, multi-compartment neuron simulations. This report documents the implementation of neuron devices in Xyce, their use in simulation and analysis of neuron systems.

Construction of dynamic stochastic simulation models using knowledge-based techniques

NASA Technical Reports Server (NTRS)

Williams, M. Douglas; Shiva, Sajjan G.

1990-01-01

Over the past three decades, computer-based simulation models have proven themselves to be cost-effective alternatives to the more structured deterministic methods of systems analysis. During this time, many techniques, tools and languages for constructing computer-based simulation models have been developed. More recently, advances in knowledge-based system technology have led many researchers to note the similarities between knowledge-based programming and simulation technologies and to investigate the potential application of knowledge-based programming techniques to simulation modeling. The integration of conventional simulation techniques with knowledge-based programming techniques is discussed to provide a development environment for constructing knowledge-based simulation models. A comparison of the techniques used in the construction of dynamic stochastic simulation models and those used in the construction of knowledge-based systems provides the requirements for the environment. This leads to the design and implementation of a knowledge-based simulation development environment. These techniques were used in the construction of several knowledge-based simulation models including the Advanced Launch System Model (ALSYM).

Space shuttle visual simulation system design study

NASA Technical Reports Server (NTRS)

1973-01-01

A recommendation and a specification for the visual simulation system design for the space shuttle mission simulator are presented. A recommended visual system is described which most nearly meets the visual design requirements. The cost analysis of the recommended system covering design, development, manufacturing, and installation is reported. Four alternate systems are analyzed.

Modeling and simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanham, R.; Vogt, W.G.; Mickle, M.H.

1986-01-01

This book presents the papers given at a conference on computerized simulation. Topics considered at the conference included expert systems, modeling in electric power systems, power systems operating strategies, energy analysis, a linear programming approach to optimum load shedding in transmission systems, econometrics, simulation in natural gas engineering, solar energy studies, artificial intelligence, vision systems, hydrology, multiprocessors, and flow models.

Simulation System Fidelity Assessment at the Vertical Motion Simulator

NASA Technical Reports Server (NTRS)

Beard, Steven D.; Reardon, Scott E.; Tobias, Eric L.; Aponso, Bimal L.

2013-01-01

Fidelity is a word that is often used but rarely understood when talking about groundbased simulation. Assessing the cueing fidelity of a ground based flight simulator requires a comparison to actual flight data either directly or indirectly. Two experiments were conducted at the Vertical Motion Simulator using the GenHel UH-60A Black Hawk helicopter math model that was directly compared to flight data. Prior to the experiment the simulator s motion and visual system frequency responses were measured, the aircraft math model was adjusted to account for the simulator motion system delays, and the motion system gains and washouts were tuned for the individual tasks. The tuned motion system fidelity was then assessed against the modified Sinacori criteria. The first experiments showed similar handling qualities ratings (HQRs) to actual flight for a bob-up and sidestep maneuvers. The second experiment showed equivalent HQRs between flight and simulation for the ADS33 slalom maneuver for the two pilot participants. The ADS33 vertical maneuver HQRs were mixed with one pilot rating the flight and simulation the same while the second pilot rated the simulation worse. In addition to recording HQRs on the second experiment, an experimental Simulation Fidelity Rating (SFR) scale developed by the University of Liverpool was tested for applicability to engineering simulators. A discussion of the SFR scale for use on the Vertical Motion Simulator is included in this paper.

A Process for Comparing Dynamics of Distributed Space Systems Simulations

NASA Technical Reports Server (NTRS)

Cures, Edwin Z.; Jackson, Albert A.; Morris, Jeffery C.

2009-01-01

The paper describes a process that was developed for comparing the primary orbital dynamics behavior between space systems distributed simulations. This process is used to characterize and understand the fundamental fidelities and compatibilities of the modeling of orbital dynamics between spacecraft simulations. This is required for high-latency distributed simulations such as NASA s Integrated Mission Simulation and must be understood when reporting results from simulation executions. This paper presents 10 principal comparison tests along with their rationale and examples of the results. The Integrated Mission Simulation (IMSim) (formerly know as the Distributed Space Exploration Simulation (DSES)) is a NASA research and development project focusing on the technologies and processes that are related to the collaborative simulation of complex space systems involved in the exploration of our solar system. Currently, the NASA centers that are actively participating in the IMSim project are the Ames Research Center, the Jet Propulsion Laboratory (JPL), the Johnson Space Center (JSC), the Kennedy Space Center, the Langley Research Center and the Marshall Space Flight Center. In concept, each center participating in IMSim has its own set of simulation models and environment(s). These simulation tools are used to build the various simulation products that are used for scientific investigation, engineering analysis, system design, training, planning, operations and more. Working individually, these production simulations provide important data to various NASA projects.

Improvements to information management systems simulator

NASA Technical Reports Server (NTRS)

Bilek, R. W.

1972-01-01

The performance of personnel in the augmentation and improvement of the interactive IMSIM information management simulation model is summarized. With this augmented model, NASA now has even greater capabilities for the simulation of computer system configurations, data processing loads imposed on these configurations, and executive software to control system operations. Through these simulations, NASA has an extremely cost effective capability for the design and analysis of computer-based data management systems.

The Australian Computational Earth Systems Simulator

NASA Astrophysics Data System (ADS)

Mora, P.; Muhlhaus, H.; Lister, G.; Dyskin, A.; Place, D.; Appelbe, B.; Nimmervoll, N.; Abramson, D.

2001-12-01

Numerical simulation of the physics and dynamics of the entire earth system offers an outstanding opportunity for advancing earth system science and technology but represents a major challenge due to the range of scales and physical processes involved, as well as the magnitude of the software engineering effort required. However, new simulation and computer technologies are bringing this objective within reach. Under a special competitive national funding scheme to establish new Major National Research Facilities (MNRF), the Australian government together with a consortium of Universities and research institutions have funded construction of the Australian Computational Earth Systems Simulator (ACcESS). The Simulator or computational virtual earth will provide the research infrastructure to the Australian earth systems science community required for simulations of dynamical earth processes at scales ranging from microscopic to global. It will consist of thematic supercomputer infrastructure and an earth systems simulation software system. The Simulator models and software will be constructed over a five year period by a multi-disciplinary team of computational scientists, mathematicians, earth scientists, civil engineers and software engineers. The construction team will integrate numerical simulation models (3D discrete elements/lattice solid model, particle-in-cell large deformation finite-element method, stress reconstruction models, multi-scale continuum models etc) with geophysical, geological and tectonic models, through advanced software engineering and visualization technologies. When fully constructed, the Simulator aims to provide the software and hardware infrastructure needed to model solid earth phenomena including global scale dynamics and mineralisation processes, crustal scale processes including plate tectonics, mountain building, interacting fault system dynamics, and micro-scale processes that control the geological, physical and dynamic behaviour of earth systems. ACcESS represents a part of Australia's contribution to the APEC Cooperation for Earthquake Simulation (ACES) international initiative. Together with other national earth systems science initiatives including the Japanese Earth Simulator and US General Earthquake Model projects, ACcESS aims to provide a driver for scientific advancement and technological breakthroughs including: quantum leaps in understanding of earth evolution at global, crustal, regional and microscopic scales; new knowledge of the physics of crustal fault systems required to underpin the grand challenge of earthquake prediction; new understanding and predictive capabilities of geological processes such as tectonics and mineralisation.

Winter Simulation Conference, Miami Beach, Fla., December 4-6, 1978, Proceedings. Volumes 1 & 2

NASA Technical Reports Server (NTRS)

Highland, H. J. (Editor); Nielsen, N. R.; Hull, L. G.

1978-01-01

The papers report on the various aspects of simulation such as random variate generation, simulation optimization, ranking and selection of alternatives, model management, documentation, data bases, and instructional methods. Simulation studies in a wide variety of fields are described, including system design and scheduling, government and social systems, agriculture, computer systems, the military, transportation, corporate planning, ecosystems, health care, manufacturing and industrial systems, computer networks, education, energy, production planning and control, financial models, behavioral models, information systems, and inventory control.

Design of penicillin fermentation process simulation system

NASA Astrophysics Data System (ADS)

Qi, Xiaoyu; Yuan, Zhonghu; Qi, Xiaoxuan; Zhang, Wenqi

2011-10-01

Real-time monitoring for batch process attracts increasing attention. It can ensure safety and provide products with consistent quality. The design of simulation system of batch process fault diagnosis is of great significance. In this paper, penicillin fermentation, a typical non-linear, dynamic, multi-stage batch production process, is taken as the research object. A visual human-machine interactive simulation software system based on Windows operation system is developed. The simulation system can provide an effective platform for the research of batch process fault diagnosis.

Simulation system architecture design for generic communications link

NASA Technical Reports Server (NTRS)

Tsang, Chit-Sang; Ratliff, Jim

1986-01-01

This paper addresses a computer simulation system architecture design for generic digital communications systems. It addresses the issues of an overall system architecture in order to achieve a user-friendly, efficient, and yet easily implementable simulation system. The system block diagram and its individual functional components are described in detail. Software implementation is discussed with the VAX/VMS operating system used as a target environment.

Advanced manned space flight simulation and training: An investigation of simulation host computer system concepts

NASA Technical Reports Server (NTRS)

Montag, Bruce C.; Bishop, Alfred M.; Redfield, Joe B.

1989-01-01

The findings of a preliminary investigation by Southwest Research Institute (SwRI) in simulation host computer concepts is presented. It is designed to aid NASA in evaluating simulation technologies for use in spaceflight training. The focus of the investigation is on the next generation of space simulation systems that will be utilized in training personnel for Space Station Freedom operations. SwRI concludes that NASA should pursue a distributed simulation host computer system architecture for the Space Station Training Facility (SSTF) rather than a centralized mainframe based arrangement. A distributed system offers many advantages and is seen by SwRI as the only architecture that will allow NASA to achieve established functional goals and operational objectives over the life of the Space Station Freedom program. Several distributed, parallel computing systems are available today that offer real-time capabilities for time critical, man-in-the-loop simulation. These systems are flexible in terms of connectivity and configurability, and are easily scaled to meet increasing demands for more computing power.

Multi-disciplinary coupling effects for integrated design of propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1993-01-01

Effective computational simulation procedures are described for modeling the inherent multi-disciplinary interactions which govern the accurate response of propulsion systems. Results are presented for propulsion system responses including multi-disciplinary coupling effects using coupled multi-discipline thermal, structural, and acoustic tailoring; an integrated system of multi-disciplinary simulators; coupled material behavior/fabrication process tailoring; sensitivities using a probabilistic simulator; and coupled materials, structures, fracture, and probabilistic behavior simulator. The results demonstrate that superior designs can be achieved if the analysis/tailoring methods account for the multi-disciplinary coupling effects. The coupling across disciplines can be used to develop an integrated coupled multi-discipline numerical propulsion system simulator.

Multi-disciplinary coupling for integrated design of propulsion systems

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Singhal, S. N.

1993-01-01

Effective computational simulation procedures are described for modeling the inherent multi-disciplinary interactions for determining the true response of propulsion systems. Results are presented for propulsion system responses including multi-discipline coupling effects via (1) coupled multi-discipline tailoring, (2) an integrated system of multidisciplinary simulators, (3) coupled material-behavior/fabrication-process tailoring, (4) sensitivities using a probabilistic simulator, and (5) coupled materials/structures/fracture/probabilistic behavior simulator. The results show that the best designs can be determined if the analysis/tailoring methods account for the multi-disciplinary coupling effects. The coupling across disciplines can be used to develop an integrated interactive multi-discipline numerical propulsion system simulator.

Future directions in flight simulation: A user perspective

NASA Technical Reports Server (NTRS)

Jackson, Bruce

1993-01-01

Langley Research Center was an early leader in simulation technology, including a special emphasis in space vehicle simulations such as the rendezvous and docking simulator for the Gemini program and the lunar landing simulator used before Apollo. In more recent times, Langley operated the first synergistic six degree of freedom motion platform (the Visual Motion Simulator, or VMS) and developed the first dual-dome air combat simulator, the Differential Maneuvering Simulator (DMS). Each Langley simulator was developed more or less independently from one another with different programming support. At present time, the various simulation cockpits, while supported by the same host computer system, run dissimilar software. The majority of recent investments in Langley's simulation facilities have been hardware procurements: host processors, visual systems, and most recently, an improved motion system. Investments in software improvements, however, have not been of the same order.

Communication interval selection in distributed heterogeneous simulation of large-scale dynamical systems

NASA Astrophysics Data System (ADS)

Lucas, Charles E.; Walters, Eric A.; Jatskevich, Juri; Wasynczuk, Oleg; Lamm, Peter T.

2003-09-01

In this paper, a new technique useful for the numerical simulation of large-scale systems is presented. This approach enables the overall system simulation to be formed by the dynamic interconnection of the various interdependent simulations, each representing a specific component or subsystem such as control, electrical, mechanical, hydraulic, or thermal. Each simulation may be developed separately using possibly different commercial-off-the-shelf simulation programs thereby allowing the most suitable language or tool to be used based on the design/analysis needs. These subsystems communicate the required interface variables at specific time intervals. A discussion concerning the selection of appropriate communication intervals is presented herein. For the purpose of demonstration, this technique is applied to a detailed simulation of a representative aircraft power system, such as that found on the Joint Strike Fighter (JSF). This system is comprised of ten component models each developed using MATLAB/Simulink, EASY5, or ACSL. When the ten component simulations were distributed across just four personal computers (PCs), a greater than 15-fold improvement in simulation speed (compared to the single-computer implementation) was achieved.

Modeling and HIL Simulation of Flight Conditions Simulating Control System for the Altitude Test Facility

NASA Astrophysics Data System (ADS)

Zhou, Jun; Shen, Li; Zhang, Tianhong

2016-12-01

Simulated altitude test is an essential exploring, debugging, verification and validation means during the development of aero-engine. Free-jet engine test can simulate actual working conditions of aero-engine more realistically than direct-connect engine test but with relatively lower cost compared to propulsion wind tunnel test, thus becoming an important developing area of simulated altitude test technology. The Flight Conditions Simulating Control System (FCSCS) is of great importance to the Altitude Test Facility (ATF) but the development of that is a huge challenge. Aiming at improving the design efficiency and reducing risks during the development of FCSCS for ATFs, a Hardware- in-the-Loop (HIL) simulation system was designed and the mathematical models of key components such as the pressure stabilizing chamber, free-jet nozzle, control valve and aero-engine were built in this paper. Moreover, some HIL simulation experiments were carried out. The results show that the HIL simulation system designed and established in this paper is reasonable and effective, which can be used to adjust control parameters conveniently and assess the software and hardware in the control system immediately.

System Simulation by Recursive Feedback: Coupling a Set of Stand-Alone Subsystem Simulations

NASA Technical Reports Server (NTRS)

Nixon, D. D.

2001-01-01

Conventional construction of digital dynamic system simulations often involves collecting differential equations that model each subsystem, arran g them to a standard form, and obtaining their numerical gin solution as a single coupled, total-system simultaneous set. Simulation by numerical coupling of independent stand-alone subsimulations is a fundamentally different approach that is attractive because, among other things, the architecture naturally facilitates high fidelity, broad scope, and discipline independence. Recursive feedback is defined and discussed as a candidate approach to multidiscipline dynamic system simulation by numerical coupling of self-contained, single-discipline subsystem simulations. A satellite motion example containing three subsystems (orbit dynamics, attitude dynamics, and aerodynamics) has been defined and constructed using this approach. Conventional solution methods are used in the subsystem simulations. Distributed and centralized implementations of coupling have been considered. Numerical results are evaluated by direct comparison with a standard total-system, simultaneous-solution approach.

Design and validation of the eyesafe ladar testbed (ELT) using the LadarSIM system simulator

NASA Astrophysics Data System (ADS)

Neilsen, Kevin D.; Budge, Scott E.; Pack, Robert T.; Fullmer, R. Rees; Cook, T. Dean

2009-05-01

The development of an experimental full-waveform LADAR system has been enhanced with the assistance of the LadarSIM system simulation software. The Eyesafe LADAR Test-bed (ELT) was designed as a raster scanning, single-beam, energy-detection LADAR with the capability of digitizing and recording the return pulse waveform at up to 2 GHz for 3D off-line image formation research in the laboratory. To assist in the design phase, the full-waveform LADAR simulation in LadarSIM was used to simulate the expected return waveforms for various system design parameters, target characteristics, and target ranges. Once the design was finalized and the ELT constructed, the measured specifications of the system and experimental data captured from the operational sensor were used to validate the behavior of the system as predicted during the design phase. This paper presents the methodology used, and lessons learned from this "design, build, validate" process. Simulated results from the design phase are presented, and these are compared to simulated results using measured system parameters and operational sensor data. The advantages of this simulation-based process are also presented.

Large liquid rocket engine transient performance simulation system

NASA Technical Reports Server (NTRS)

Mason, J. R.; Southwick, R. D.

1991-01-01

A simulation system, ROCETS, was designed and developed to allow cost-effective computer predictions of liquid rocket engine transient performance. The system allows a user to generate a simulation of any rocket engine configuration using component modules stored in a library through high-level input commands. The system library currently contains 24 component modules, 57 sub-modules and maps, and 33 system routines and utilities. FORTRAN models from other sources can be operated in the system upon inclusion of interface information on comment cards. Operation of the simulation is simplified for the user by run, execution, and output processors. The simulation system makes available steady-state trim balance, transient operation, and linear partial generation. The system utilizes a modern equation solver for efficient operation of the simulations. Transient integration methods include integral and differential forms for the trapezoidal, first order Gear, and second order Gear corrector equations. A detailed technology test bed engine (TTBE) model was generated to be used as the acceptance test of the simulation system. The general level of model detail was that reflected in the Space Shuttle Main Engine DTM. The model successfully obtained steady-state balance in main stage operation and simulated throttle transients, including engine starts and shutdown. A NASA FORTRAN control model was obtained, ROCETS interface installed in comment cards, and operated with the TTBE model in closed-loop transient mode.

Design and Simulation of Horn Antenna Using CST Software for GPR System

NASA Astrophysics Data System (ADS)

Joret, Ariffuddin; Sulong, M. S.; Abdullah, M. F. L.; Madun, Aziman; Haimi Dahlan, Samsul

2018-04-01

Detection of underground object can be made using a GPR system. This system is classified as a non-destructive technique (NDT) where the ground areas need not to be excavated. The technique used by the GPR system is by measuring the reflection of electromagnetic wave signal produced and detected by antenna which is known as the transmitter and the receiver antenna. In this study, a GPR system was studied by means of simulation using a Horn antenna as a transceiver antenna. The electromagnetic wave signal in this simulation is produced by current signal of an antenna which having a shape of modulation of Gaussian pulse which is having spectrum from 8 GHz until 12 GHz. CST and MATLAB Software are used in this GPR system simulation. A model of a Horn antenna has been designed using the CST software before the GPR’s system simulation modeled by adding a model of background in front of the Horn antenna. The simulation results show that the output signal of the Horn antenna can be used in detecting embedded object which are made from material of wood and iron. In addition, the simulation result has successfully developed a 3D model image of the GPR system using output signal of the Horn antenna. The embedded iron object in the GPR system simulation can be seen clearly by using this 3D image.

Distribution system simulator

NASA Technical Reports Server (NTRS)

Bahrami, K. A.; Kirkham, H.; Rahman, S.

1986-01-01

In a series of tests performed under the Department of Energy auspices, power line carrier propagation was observed to be anomalous under certain circumstances. To investigate the cause, a distribution system simulator was constructed. The simulator was a physical simulator that accurately represented the distribution system from below power frequency to above 50 kHz. Effects such as phase-to-phase coupling and skin effect were modeled. Construction details of the simulator, and experimental results from its use are presented.

Optimal generalized multistep integration formulae for real-time digital simulation

NASA Technical Reports Server (NTRS)

Moerder, D. D.; Halyo, N.

1985-01-01

The problem of discretizing a dynamical system for real-time digital simulation is considered. Treating the system and its simulation as stochastic processes leads to a statistical characterization of simulator fidelity. A plant discretization procedure based on an efficient matrix generalization of explicit linear multistep discrete integration formulae is introduced, which minimizes a weighted sum of the mean squared steady-state and transient error between the system and simulator outputs.

Argonne Simulation Framework for Intelligent Transportation Systems

DOT National Transportation Integrated Search

1996-01-01

A simulation framework has been developed which defines a high-level architecture for a large-scale, comprehensive, scalable simulation of an Intelligent Transportation System (ITS). The simulator is designed to run on parallel computers and distribu...

Melting Penetration Simulation of Fe-U System at High Temperature Using MPS_LER

NASA Astrophysics Data System (ADS)

Mustari, A. P. A.; Yamaji, A.; Irwanto, Dwi

2016-08-01

Melting penetration information of Fe-U system is necessary for simulating the molten core behavior during severe accident in nuclear power plants. For Fe-U system, the information is mainly obtained from experiment, i.e. TREAT experiment. However, there is no reported data on SS304 at temperature above 1350°C. The MPS_LER has been developed and validated to simulate melting penetration on Fe-U system. The MPS_LER modelled the eutectic phenomenon by solving the diffusion process and by applying the binary phase diagram criteria. This study simulates the melting penetration of the system at higher temperature using MPS_LER. Simulations were conducted on SS304 at 1400, 1450 and 1500°C. The simulation results show rapid increase of melting penetration rate.

Development of Simulated Disturbing Source for Isolation Switch

NASA Astrophysics Data System (ADS)

Cheng, Lin; Liu, Xiang; Deng, Xiaoping; Pan, Zhezhe; Zhou, Hang; Zhu, Yong

2018-01-01

In order to simulate the substation in the actual scene of the harsh electromagnetic environment, and then research on electromagnetic compatibility testing of electronic instrument transformer, On the basis of the original isolation switch as a harassment source of the electronic instrument transformer electromagnetic compatibility test system, an isolated switch simulation source system was developed, to promote the standardization of the original test. In this paper, the circuit breaker is used to control the opening and closing of the gap arc to simulate the operating of isolating switch, and the isolation switch simulation harassment source system is designed accordingly. Comparison with the actual test results of the isolating switch, it is proved that the system can meet the test requirements, and the simulation harassment source system has good stability and high reliability.

The Numerical Propulsion System Simulation: A Multidisciplinary Design System for Aerospace Vehicles

NASA Technical Reports Server (NTRS)

Lytle, John K.

1999-01-01

Advances in computational technology and in physics-based modeling are making large scale, detailed simulations of complex systems possible within the design environment. For example, the integration of computing, communications, and aerodynamics has reduced the time required to analyze ma or propulsion system components from days and weeks to minutes and hours. This breakthrough has enabled the detailed simulation of major propulsion system components to become a routine part of design process and to provide the designer with critical information about the components early in the design process. This paper describes the development of the Numerical Propulsion System Simulation (NPSS), a multidisciplinary system of analysis tools that is focussed on extending the simulation capability from components to the full system. This will provide the product developer with a "virtual wind tunnel" that will reduce the number of hardware builds and tests required during the development of advanced aerospace propulsion systems.

Using soft systems methodology to develop a simulation of out-patient services.

PubMed

Lehaney, B; Paul, R J

1994-10-01

Discrete event simulation is an approach to modelling a system in the form of a set of mathematical equations and logical relationships, usually used for complex problems, which are difficult to address by using analytical or numerical methods. Managing out-patient services is such a problem. However, simulation is not in itself a systemic approach, in that it provides no methodology by which system boundaries and system activities may be identified. The investigation considers the use of soft systems methodology as an aid to drawing system boundaries and identifying system activities, for the purpose of simulating the outpatients' department at a local hospital. The long term aims are to examine the effects that the participative nature of soft systems methodology has on the acceptability of the simulation model, and to provide analysts and managers with a process that may assist in planning strategies for health care.

The simulation study on optical target laser active detection performance

NASA Astrophysics Data System (ADS)

Li, Ying-chun; Hou, Zhao-fei; Fan, Youchen

2014-12-01

According to the working principle of laser active detection system, the paper establishes the optical target laser active detection simulation system, carry out the simulation study on the detection process and detection performance of the system. For instance, the performance model such as the laser emitting, the laser propagation in the atmosphere, the reflection of optical target, the receiver detection system, the signal processing and recognition. We focus on the analysis and modeling the relationship between the laser emitting angle and defocus amount and "cat eye" effect echo laser in the reflection of optical target. Further, in the paper some performance index such as operating range, SNR and the probability of the system have been simulated. The parameters including laser emitting parameters, the reflection of the optical target and the laser propagation in the atmosphere which make a great influence on the performance of the optical target laser active detection system. Finally, using the object-oriented software design methods, the laser active detection system with the opening type, complete function and operating platform, realizes the process simulation that the detection system detect and recognize the optical target, complete the performance simulation of each subsystem, and generate the data report and the graph. It can make the laser active detection system performance models more intuitive because of the visible simulation process. The simulation data obtained from the system provide a reference to adjust the structure of the system parameters. And it provides theoretical and technical support for the top level design of the optical target laser active detection system and performance index optimization.

Simulation studies for the evaluation of health information technologies: experiences and results.

PubMed

Ammenwerth, Elske; Hackl, Werner O; Binzer, Kristine; Christoffersen, Tue E H; Jensen, Sanne; Lawton, Kitta; Skjoet, Peter; Nohr, Christian

It is essential for new health information technologies (IT) to undergo rigorous evaluations to ensure they are effective and safe for use in real-world situations. However, evaluation of new health IT is challenging, as field studies are often not feasible when the technology being evaluated is not sufficiently mature. Laboratory-based evaluations have also been shown to have insufficient external validity. Simulation studies seem to be a way to bridge this gap. The aim of this study was to evaluate, using a simulation methodology, the impact of a new prototype of an electronic medication management system on the appropriateness of prescriptions and drug-related activities, including laboratory test ordering or medication changes. This article presents the results of a controlled simulation study with 50 simulation runs, including ten doctors and five simulation patients, and discusses experiences and lessons learnt while conducting the study. Although the new electronic medication management system showed tendencies to improve medication safety when compared with the standard system, this tendency was not significant. Altogether, five distinct situations were identified where the new medication management system did help to improve medication safety. This simulation study provided a good compromise between internal validity and external validity. However, several challenges need to be addressed when undertaking simulation evaluations including: preparation of adequate test cases; training of participants before using unfamiliar applications; consideration of time, effort and costs of conducting the simulation; technical maturity of the evaluated system; and allowing adequate preparation of simulation scenarios and simulation setting. Simulation studies are an interesting but time-consuming approach, which can be used to evaluate newly developed health IT systems, particularly those systems that are not yet sufficiently mature to undergo field evaluation studies.

Acceleration techniques for dependability simulation. M.S. Thesis

NASA Technical Reports Server (NTRS)

Barnette, James David

1995-01-01

As computer systems increase in complexity, the need to project system performance from the earliest design and development stages increases. We have to employ simulation for detailed dependability studies of large systems. However, as the complexity of the simulation model increases, the time required to obtain statistically significant results also increases. This paper discusses an approach that is application independent and can be readily applied to any process-based simulation model. Topics include background on classical discrete event simulation and techniques for random variate generation and statistics gathering to support simulation.

Dshell++: A Component Based, Reusable Space System Simulation Framework

NASA Technical Reports Server (NTRS)

Lim, Christopher S.; Jain, Abhinandan

2009-01-01

This paper describes the multi-mission Dshell++ simulation framework for high fidelity, physics-based simulation of spacecraft, robotic manipulation and mobility systems. Dshell++ is a C++/Python library which uses modern script driven object-oriented techniques to allow component reuse and a dynamic run-time interface for complex, high-fidelity simulation of spacecraft and robotic systems. The goal of the Dshell++ architecture is to manage the inherent complexity of physicsbased simulations while supporting component model reuse across missions. The framework provides several features that support a large degree of simulation configurability and usability.

Computer Simulation and Field Experiment for Downlink Multiuser MIMO in Mobile WiMAX System.

PubMed

Yamaguchi, Kazuhiro; Nagahashi, Takaharu; Akiyama, Takuya; Matsue, Hideaki; Uekado, Kunio; Namera, Takakazu; Fukui, Hiroshi; Nanamatsu, Satoshi

2015-01-01

The transmission performance for a downlink mobile WiMAX system with multiuser multiple-input multiple-output (MU-MIMO) systems in a computer simulation and field experiment is described. In computer simulation, a MU-MIMO transmission system can be realized by using the block diagonalization (BD) algorithm, and each user can receive signals without any signal interference from other users. The bit error rate (BER) performance and channel capacity in accordance with modulation schemes and the number of streams were simulated in a spatially correlated multipath fading environment. Furthermore, we propose a method for evaluating the transmission performance for this downlink mobile WiMAX system in this environment by using the computer simulation. In the field experiment, the received power and downlink throughput in the UDP layer were measured on an experimental mobile WiMAX system developed in Azumino City in Japan. In comparison with the simulated and experimented results, the measured maximum throughput performance in the downlink had almost the same performance as the simulated throughput. It was confirmed that the experimental mobile WiMAX system for MU-MIMO transmission successfully increased the total channel capacity of the system.

Computer Simulation and Field Experiment for Downlink Multiuser MIMO in Mobile WiMAX System

PubMed Central

Yamaguchi, Kazuhiro; Nagahashi, Takaharu; Akiyama, Takuya; Matsue, Hideaki; Uekado, Kunio; Namera, Takakazu; Fukui, Hiroshi; Nanamatsu, Satoshi

2015-01-01

The transmission performance for a downlink mobile WiMAX system with multiuser multiple-input multiple-output (MU-MIMO) systems in a computer simulation and field experiment is described. In computer simulation, a MU-MIMO transmission system can be realized by using the block diagonalization (BD) algorithm, and each user can receive signals without any signal interference from other users. The bit error rate (BER) performance and channel capacity in accordance with modulation schemes and the number of streams were simulated in a spatially correlated multipath fading environment. Furthermore, we propose a method for evaluating the transmission performance for this downlink mobile WiMAX system in this environment by using the computer simulation. In the field experiment, the received power and downlink throughput in the UDP layer were measured on an experimental mobile WiMAX system developed in Azumino City in Japan. In comparison with the simulated and experimented results, the measured maximum throughput performance in the downlink had almost the same performance as the simulated throughput. It was confirmed that the experimental mobile WiMAX system for MU-MIMO transmission successfully increased the total channel capacity of the system. PMID:26421311

A method of Modelling and Simulating the Back-to-Back Modular Multilevel Converter HVDC Transmission System

NASA Astrophysics Data System (ADS)

Wang, Lei; Fan, Youping; Zhang, Dai; Ge, Mengxin; Zou, Xianbin; Li, Jingjiao

2017-09-01

This paper proposes a method to simulate a back-to-back modular multilevel converter (MMC) HVDC transmission system. In this paper we utilize an equivalent networks to simulate the dynamic power system. Moreover, to account for the performance of converter station, core components of model of the converter station gives a basic model of simulation. The proposed method is applied to an equivalent real power system.

INTEGRATING DATA ANALYTICS AND SIMULATION METHODS TO SUPPORT MANUFACTURING DECISION MAKING

PubMed Central

Kibira, Deogratias; Hatim, Qais; Kumara, Soundar; Shao, Guodong

2017-01-01

Modern manufacturing systems are installed with smart devices such as sensors that monitor system performance and collect data to manage uncertainties in their operations. However, multiple parameters and variables affect system performance, making it impossible for a human to make informed decisions without systematic methodologies and tools. Further, the large volume and variety of streaming data collected is beyond simulation analysis alone. Simulation models are run with well-prepared data. Novel approaches, combining different methods, are needed to use this data for making guided decisions. This paper proposes a methodology whereby parameters that most affect system performance are extracted from the data using data analytics methods. These parameters are used to develop scenarios for simulation inputs; system optimizations are performed on simulation data outputs. A case study of a machine shop demonstrates the proposed methodology. This paper also reviews candidate standards for data collection, simulation, and systems interfaces. PMID:28690363

Apparatus and method for interaction phenomena with world modules in data-flow-based simulation

DOEpatents

Xavier, Patrick G [Albuquerque, NM; Gottlieb, Eric J [Corrales, NM; McDonald, Michael J [Albuquerque, NM; Oppel, III, Fred J.

2006-08-01

A method and apparatus accommodate interaction phenomenon in a data-flow-based simulation of a system of elements, by establishing meta-modules to simulate system elements and by establishing world modules associated with interaction phenomena. World modules are associated with proxy modules from a group of meta-modules associated with one of the interaction phenomenon. The world modules include a communication world, a sensor world, a mobility world, and a contact world. World modules can be further associated with other world modules if necessary. Interaction phenomenon are simulated in corresponding world modules by accessing member functions in the associated group of proxy modules. Proxy modules can be dynamically allocated at a desired point in the simulation to accommodate the addition of elements in the system of elements such as a system of robots, a system of communication terminals, or a system of vehicles, being simulated.

Modeling the long-term evolution of space debris

DOEpatents

Nikolaev, Sergei; De Vries, Willem H.; Henderson, John R.; Horsley, Matthew A.; Jiang, Ming; Levatin, Joanne L.; Olivier, Scot S.; Pertica, Alexander J.; Phillion, Donald W.; Springer, Harry K.

2017-03-07

A space object modeling system that models the evolution of space debris is provided. The modeling system simulates interaction of space objects at simulation times throughout a simulation period. The modeling system includes a propagator that calculates the position of each object at each simulation time based on orbital parameters. The modeling system also includes a collision detector that, for each pair of objects at each simulation time, performs a collision analysis. When the distance between objects satisfies a conjunction criterion, the modeling system calculates a local minimum distance between the pair of objects based on a curve fitting to identify a time of closest approach at the simulation times and calculating the position of the objects at the identified time. When the local minimum distance satisfies a collision criterion, the modeling system models the debris created by the collision of the pair of objects.

New Automotive Air Conditioning System Simulation Tool Developed in MATLAB/Simulink

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kiss, T.; Chaney, L.; Meyer, J.

Further improvements in vehicle fuel efficiency require accurate evaluation of the vehicle's transient total power requirement. When operated, the air conditioning (A/C) system is the largest auxiliary load on a vehicle; therefore, accurate evaluation of the load it places on the vehicle's engine and/or energy storage system is especially important. Vehicle simulation software, such as 'Autonomie,' has been used by OEMs to evaluate vehicles' energy performance. A transient A/C simulation tool incorporated into vehicle simulation models would also provide a tool for developing more efficient A/C systems through a thorough consideration of the transient A/C system performance. The dynamic systemmore » simulation software Matlab/Simulink was used to develop new and more efficient vehicle energy system controls. The various modeling methods used for the new simulation tool are described in detail. Comparison with measured data is provided to demonstrate the validity of the model.« less

Operating system for a real-time multiprocessor propulsion system simulator. User's manual

NASA Technical Reports Server (NTRS)

Cole, G. L.

1985-01-01

The NASA Lewis Research Center is developing and evaluating experimental hardware and software systems to help meet future needs for real-time, high-fidelity simulations of air-breathing propulsion systems. Specifically, the real-time multiprocessor simulator project focuses on the use of multiple microprocessors to achieve the required computing speed and accuracy at relatively low cost. Operating systems for such hardware configurations are generally not available. A real time multiprocessor operating system (RTMPOS) that supports a variety of multiprocessor configurations was developed at Lewis. With some modification, RTMPOS can also support various microprocessors. RTMPOS, by means of menus and prompts, provides the user with a versatile, user-friendly environment for interactively loading, running, and obtaining results from a multiprocessor-based simulator. The menu functions are described and an example simulation session is included to demonstrate the steps required to go from the simulation loading phase to the execution phase.

Multimode marine engine room simulation system based on field bus technology

NASA Astrophysics Data System (ADS)

Zheng, Huayao; Deng, Linlin; Guo, Yi

2003-09-01

Developing multi mode MER (Marine Engine Room) Labs is the main work in Marine Simulation Center, which is the key lab of Communication Ministry of China. It includes FPP (Fixed Pitch Propeller) and CPP (Controllable Pitch Propeller) mode MER simulation systems, integrated electrical propulsion mode MER simulation system, physical mode MER lab, etc. FPP mode simulation system, which was oriented to large container ship, had been completed since 1999, and got second level of Shanghai Municipal Science and Technical Progress award. This paper mainly introduces the recent development and achievements of Marine Simulation Center. Based on the Lon Works field bus, the structure characteristics and control strategies of completely distributed intelligent control network are discussed. The experiment mode of multi-nodes field bus detection and control system is described. Besides, intelligent fault diagnosis technology about some mechatronics integration control systems explored is also involved.

Dynamic extension of the Simulation Problem Analysis Kernel (SPANK)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sowell, E.F.; Buhl, W.F.

1988-07-15

The Simulation Problem Analysis Kernel (SPANK) is an object-oriented simulation environment for general simulation purposes. Among its unique features is use of the directed graph as the primary data structure, rather than the matrix. This allows straightforward use of graph algorithms for matching variables and equations, and reducing the problem graph for efficient numerical solution. The original prototype implementation demonstrated the principles for systems of algebraic equations, allowing simulation of steady-state, nonlinear systems (Sowell 1986). This paper describes how the same principles can be extended to include dynamic objects, allowing simulation of general dynamic systems. The theory is developed andmore » an implementation is described. An example is taken from the field of building energy system simulation. 2 refs., 9 figs.« less

Simulator training with a forward collision warning system: effects on driver-system interactions and driver trust.

PubMed

Koustanaï, Arnaud; Cavallo, Viola; Delhomme, Patricia; Mas, Arnaud

2012-10-01

The study addressed the role of familiarization on a driving simulator with a forward collision warning (FCW) and investigated its impact on driver behavior. Drivers need a good understanding of how an FCW system functions to trust it and use it properly. Theoretical and empirical data suggest that exploring the capacities and limitations of the FCW during the learning period improves operating knowledge and leads to increased driver trust in the system and better driver-system interactions.The authors tested this hypothesis by comparing groups of drivers differing in FCW familiarity. During the familiarization phase, familiarized drivers were trained on the simulator using the FCW, unfamiliarized drivers simply read an FCW manual, and control drivers had no contact with the FCW. During the test, drivers drove the simulator and had to interact with traffic; both familiarized and unfamiliarized drivers used the FCW, whereas controls did not. Simulator familiarization improved driver understanding of FCW operation. Driver-system interactions were more effective: Familiarized drivers had no collisions, longer time headways, and better reactions in most situations. Familiarization increased trust in the FCW but did not raise system acceptance. Familiarization on the simulator had a positive effect on driver-system interactions and on trust in the system. The limitations of the familiarization method are discussed in relation to the driving simulator methodology. Practicing on a driving simulator with driving-assistance systems could facilitate their use during real driving.

Development of process control capability through the Browns Ferry Integrated Computer System using Reactor Water Clanup System as an example. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, J.; Mowrey, J.

1995-12-01

This report describes the design, development and testing of process controls for selected system operations in the Browns Ferry Nuclear Plant (BFNP) Reactor Water Cleanup System (RWCU) using a Computer Simulation Platform which simulates the RWCU System and the BFNP Integrated Computer System (ICS). This system was designed to demonstrate the feasibility of the soft control (video touch screen) of nuclear plant systems through an operator console. The BFNP Integrated Computer System, which has recently. been installed at BFNP Unit 2, was simulated to allow for operator control functions of the modeled RWCU system. The BFNP Unit 2 RWCU systemmore » was simulated using the RELAP5 Thermal/Hydraulic Simulation Model, which provided the steady-state and transient RWCU process variables and simulated the response of the system to control system inputs. Descriptions of the hardware and software developed are also included in this report. The testing and acceptance program and results are also detailed in this report. A discussion of potential installation of an actual RWCU process control system in BFNP Unit 2 is included. Finally, this report contains a section on industry issues associated with installation of process control systems in nuclear power plants.« less

Research in Distance Education: A System Modeling Approach.

ERIC Educational Resources Information Center

Saba, Farhad; Twitchell, David

1988-01-01

Describes how a computer simulation research method can be used for studying distance education systems. Topics discussed include systems research in distance education; a technique of model development using the System Dynamics approach and DYNAMO simulation language; and a computer simulation of a prototype model. (18 references) (LRW)

System-Level Reuse of Space Systems Simulations

NASA Technical Reports Server (NTRS)

Hazen, Michael R.; Williams, Joseph C.

2004-01-01

One of the best ways to enhance space systems simulation fidelity is to leverage off of (reuse) existing high-fidelity simulations. But what happens when the model you would like to reuse is in a different coding language or other barriers arise that make one want to just start over with a clean sheet of paper? Three diverse system-level simulation reuse case studies are described based on experience to date in the development of NASA's Space Station Training Facility (SSTF) at the Johnson Space Center in Houston, Texas. Case studies include (a) the Boeing/Rocketdyne-provided Electrical Power Simulation (EPSIM), (b) the NASA Automation and Robotics Division-provided TRICK robotics systems model, and (c) the Russian Space Agency- provided Russian Segment Trainer. In each case, there was an initial tendency to dismiss simulation reuse candidates based on an apparent lack of suitability. A more careful examination based on a more structured assessment of architectural and requirements-oriented representations of the reuse candidates revealed significant reuse potential. Specific steps used to conduct the detailed assessments are discussed. The steps include the following: 1) Identifying reuse candidates; 2) Requirements compatibility assessment; 3) Maturity assessment; 4) Life-cycle cost determination; and 5) Risk assessment. Observations and conclusions are presented related to the real cost of system-level simulation component reuse. Finally, lessons learned that relate to maximizing the benefits of space systems simulation reuse are shared. These concepts should be directly applicable for use in the development of space systems simulations in the future.

Applying Reduced Generator Models in the Coarse Solver of Parareal in Time Parallel Power System Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duan, Nan; Dimitrovski, Aleksandar D; Simunovic, Srdjan

2016-01-01

The development of high-performance computing techniques and platforms has provided many opportunities for real-time or even faster-than-real-time implementation of power system simulations. One approach uses the Parareal in time framework. The Parareal algorithm has shown promising theoretical simulation speedups by temporal decomposing a simulation run into a coarse simulation on the entire simulation interval and fine simulations on sequential sub-intervals linked through the coarse simulation. However, it has been found that the time cost of the coarse solver needs to be reduced to fully exploit the potentials of the Parareal algorithm. This paper studies a Parareal implementation using reduced generatormore » models for the coarse solver and reports the testing results on the IEEE 39-bus system and a 327-generator 2383-bus Polish system model.« less

High Performance Simulations of Accretion Disk Dynamics and Jet Formations Around Kerr Black Holes

NASA Technical Reports Server (NTRS)

Nishikawa, Ken-Ichi; Mizuno, Yosuke; Watson, Michael

2007-01-01

We investigate jet formation in black-hole systems using 3-D General Relativistic Particle-In-Cell (GRPIC) and 3-D GRMHD simulations. GRPIC simulations, which allow charge separations in a collisionless plasma, do not need to invoke the frozen condition as in GRMHD simulations. 3-D GRPIC simulations show that jets are launched from Kerr black holes as in 3-D GRMHD simulations, but jet formation in the two cases may not be identical. Comparative study of black hole systems with GRPIC and GRMHD simulations with the inclusion of radiate transfer will further clarify the mechanisms that drive the evolution of disk-jet systems.

Grounded Learning Experience: Helping Students Learn Physics through Visuo-Haptic Priming and Instruction

NASA Astrophysics Data System (ADS)

Huang, Shih-Chieh Douglas

In this dissertation, I investigate the effects of a grounded learning experience on college students' mental models of physics systems. The grounded learning experience consisted of a priming stage and an instruction stage, and within each stage, one of two different types of visuo-haptic representation was applied: visuo-gestural simulation (visual modality and gestures) and visuo-haptic simulation (visual modality, gestures, and somatosensory information). A pilot study involving N = 23 college students examined how using different types of visuo-haptic representation in instruction affected people's mental model construction for physics systems. Participants' abilities to construct mental models were operationalized through their pretest-to-posttest gain scores for a basic physics system and their performance on a transfer task involving an advanced physics system. Findings from this pilot study revealed that, while both simulations significantly improved participants' mental modal construction for physics systems, visuo-haptic simulation was significantly better than visuo-gestural simulation. In addition, clinical interviews suggested that participants' mental model construction for physics systems benefited from receiving visuo-haptic simulation in a tutorial prior to the instruction stage. A dissertation study involving N = 96 college students examined how types of visuo-haptic representation in different applications support participants' mental model construction for physics systems. Participant's abilities to construct mental models were again operationalized through their pretest-to-posttest gain scores for a basic physics system and their performance on a transfer task involving an advanced physics system. Participants' physics misconceptions were also measured before and after the grounded learning experience. Findings from this dissertation study not only revealed that visuo-haptic simulation was significantly more effective in promoting mental model construction and remedying participants' physics misconceptions than visuo-gestural simulation, they also revealed that visuo-haptic simulation was more effective during the priming stage than during the instruction stage. Interestingly, the effects of visuo-haptic simulation in priming and visuo-haptic simulation in instruction on participants' pretest-to-posttest gain scores for a basic physics system appeared additive. These results suggested that visuo-haptic simulation is effective in physics learning, especially when it is used during the priming stage.

Knowledge Based Simulation: An Artificial Intelligence Approach to System Modeling and Automating the Simulation Life Cycle.

DTIC Science & Technology

1988-04-13

Simulation: An Artificial Intelligence Approach to System Modeling and Automating the Simulation Life Cycle Mark S. Fox, Nizwer Husain, Malcolm...McRoberts and Y.V.Reddy CMU-RI-TR-88-5 Intelligent Systems Laboratory The Robotics Institute Carnegie Mellon University Pittsburgh, Pennsylvania D T T 13...years of research in the application of Artificial Intelligence to Simulation. Our focus has been in two areas: the use of Al knowledge representation

Decentralized real-time simulation of forest machines

NASA Astrophysics Data System (ADS)

Freund, Eckhard; Adam, Frank; Hoffmann, Katharina; Rossmann, Juergen; Kraemer, Michael; Schluse, Michael

2000-10-01

To develop realistic forest machine simulators is a demanding task. A useful simulator has to provide a close- to-reality simulation of the forest environment as well as the simulation of the physics of the vehicle. Customers demand a highly realistic three dimensional forestry landscape and the realistic simulation of the complex motion of the vehicle even in rough terrain in order to be able to use the simulator for operator training under close-to- reality conditions. The realistic simulation of the vehicle, especially with the driver's seat mounted on a motion platform, greatly improves the effect of immersion into the virtual reality of a simulated forest and the achievable level of education of the driver. Thus, the connection of the real control devices of forest machines to the simulation system has to be supported, i.e. the real control devices like the joysticks or the board computer system to control the crane, the aggregate etc. Beyond, the fusion of the board computer system and the simulation system is realized by means of sensors, i.e. digital and analog signals. The decentralized system structure allows several virtual reality systems to evaluate and visualize the information of the control devices and the sensors. So, while the driver is practicing, the instructor can immerse into the same virtual forest to monitor the session from his own viewpoint. In this paper, we are describing the realized structure as well as the necessary software and hardware components and application experiences.

Investigation of Cross-Linked and Additive Containing Polymer Materials for Membranes with Improved Performance in Pervaporation and Gas Separation

PubMed Central

Hunger, Katharina; Schmeling, Nadine; Jeazet, Harold B. Tanh; Janiak, Christoph; Staudt, Claudia; Kleinermanns, Karl

2012-01-01

Pervaporation and gas separation performances of polymer membranes can be improved by crosslinking or addition of metal-organic frameworks (MOFs). Crosslinked copolyimide membranes show higher plasticization resistance and no significant loss in selectivity compared to non-crosslinked membranes when exposed to mixtures of CO2/CH4 or toluene/cyclohexane. Covalently crosslinked membranes reveal better separation performances than ionically crosslinked systems. Covalent interlacing with 3-hydroxypropyldimethylmaleimide as photocrosslinker can be investigated in situ in solution as well as in films, using transient UV/Vis and FTIR spectroscopy. The photocrosslinking yield can be determined from the FTIR-spectra. It is restricted by the stiffness of the copolyimide backbone, which inhibits the photoreaction due to spatial separation of the crosslinker side chains. Mixed-matrix membranes (MMMs) with MOFs as additives (fillers) have increased permeabilities and often also selectivities compared to the pure polymer. Incorporation of MOFs into polysulfone and Matrimid® polymers for MMMs gives defect-free membranes with performances similar to the best polymer membranes for gas mixtures, such as O2/N2 H2/CH4, CO2/CH4, H2/CO2, CH4/N2 and CO2/N2 (preferentially permeating gas is named first). The MOF porosity, its particle size and content in the MMM are factors to influence the permeability and the separation performance of the membranes. PMID:24958427

Simulating Open Quantum Systems with Hamiltonian Ensembles and the Nonclassicality of the Dynamics

NASA Astrophysics Data System (ADS)

Chen, Hong-Bin; Gneiting, Clemens; Lo, Ping-Yuan; Chen, Yueh-Nan; Nori, Franco

2018-01-01

The incoherent dynamical properties of open quantum systems are generically attributed to an ongoing correlation between the system and its environment. Here, we propose a novel way to assess the nature of these system-environment correlations by examining the system dynamics alone. Our approach is based on the possibility or impossibility to simulate open-system dynamics with Hamiltonian ensembles. As we show, such (im)possibility to simulate is closely linked to the system-environment correlations. We thus define the nonclassicality of open-system dynamics in terms of the nonexistence of a Hamiltonian-ensemble simulation. This classifies any nonunital open-system dynamics as nonclassical. We give examples for open-system dynamics that are unital and classical, as well as unital and nonclassical.

Analyzing simulation-based PRA data through traditional and topological clustering: A BWR station blackout case study

DOE PAGES

Maljovec, D.; Liu, S.; Wang, B.; ...

2015-07-14

Here, dynamic probabilistic risk assessment (DPRA) methodologies couple system simulator codes (e.g., RELAP and MELCOR) with simulation controller codes (e.g., RAVEN and ADAPT). Whereas system simulator codes model system dynamics deterministically, simulation controller codes introduce both deterministic (e.g., system control logic and operating procedures) and stochastic (e.g., component failures and parameter uncertainties) elements into the simulation. Typically, a DPRA is performed by sampling values of a set of parameters and simulating the system behavior for that specific set of parameter values. For complex systems, a major challenge in using DPRA methodologies is to analyze the large number of scenarios generated,more » where clustering techniques are typically employed to better organize and interpret the data. In this paper, we focus on the analysis of two nuclear simulation datasets that are part of the risk-informed safety margin characterization (RISMC) boiling water reactor (BWR) station blackout (SBO) case study. We provide the domain experts a software tool that encodes traditional and topological clustering techniques within an interactive analysis and visualization environment, for understanding the structures of such high-dimensional nuclear simulation datasets. We demonstrate through our case study that both types of clustering techniques complement each other for enhanced structural understanding of the data.« less

Simulation analysis of the ground-water system in Mesozoic rocks in the Four Corners area, Utah, Colorado, Arizona, and New Mexico

USGS Publications Warehouse

Thomas, B.E.

1989-01-01

The steady-state groundwater system in Mesozoic rocks in the Four Corners area, Utah, Colorado, Arizona, and New Mexico, was simulated with a finite-difference digital-computer model to improve the understanding of the system. The simulated area is 4 ,100 sq mi, and it includes three aquifers. The Entrada-Navajo aquifer includes the Wingate, Navajo, and Entrada Sandstones. The Morrison aquifer includes the sandstone units of the Morrison Formation. The Dakota aquifer includes the Burro Canyon Formation and Dakota Sandstone. The simulation of the groundwater system had a mean error (error is absolute value of residual) of 70 ft for the Entrada-Navajo aquifer, 67 ft for the Morrison aquifer and 79 ft for the Dakota aquifer. The hydraulic conductivity used in the simulation ranged from 0.38 to 0.47 ft/day. Simulated inflow to the groundwater system was 30,000 acre-ft/yr. 48% of the inflow is from infiltration of precipitation within the simulated area, and 42% is from infiltration in 145 sq mi of mountain areas adjacent to the simulated area. Simulations indicated that some vertical inflow of water is needed between the Entrada-Navajo and Morrison aquifers to develop a reasonable representation of the system. (USGS)

Simulation Models for the Electric Power Requirements in a Guideway Transit System

DOT National Transportation Integrated Search

1980-04-01

This report describes a computer simulation model developed at the Transportation Systems Center to study the electrical power distribution characteristics of Automated Guideway Transit (AGT) systems. The objective of this simulation effort is to pro...

GATE Monte Carlo simulations for variations of an integrated PET/MR hybrid imaging system based on the Biograph mMR model

NASA Astrophysics Data System (ADS)

Aklan, B.; Jakoby, B. W.; Watson, C. C.; Braun, H.; Ritt, P.; Quick, H. H.

2015-06-01

A simulation toolkit, GATE (Geant4 Application for Tomographic Emission), was used to develop an accurate Monte Carlo (MC) simulation of a fully integrated 3T PET/MR hybrid imaging system (Siemens Biograph mMR). The PET/MR components of the Biograph mMR were simulated in order to allow a detailed study of variations of the system design on the PET performance, which are not easy to access and measure on a real PET/MR system. The 3T static magnetic field of the MR system was taken into account in all Monte Carlo simulations. The validation of the MC model was carried out against actual measurements performed on the PET/MR system by following the NEMA (National Electrical Manufacturers Association) NU 2-2007 standard. The comparison of simulated and experimental performance measurements included spatial resolution, sensitivity, scatter fraction, and count rate capability. The validated system model was then used for two different applications. The first application focused on investigating the effect of an extension of the PET field-of-view on the PET performance of the PET/MR system. The second application deals with simulating a modified system timing resolution and coincidence time window of the PET detector electronics in order to simulate time-of-flight (TOF) PET detection. A dedicated phantom was modeled to investigate the impact of TOF on overall PET image quality. Simulation results showed that the overall divergence between simulated and measured data was found to be less than 10%. Varying the detector geometry showed that the system sensitivity and noise equivalent count rate of the PET/MR system increased progressively with an increasing number of axial detector block rings, as to be expected. TOF-based PET reconstructions of the modeled phantom showed an improvement in signal-to-noise ratio and image contrast to the conventional non-TOF PET reconstructions. In conclusion, the validated MC simulation model of an integrated PET/MR system with an overall accuracy error of less than 10% can now be used for further MC simulation applications such as development of hardware components as well as for testing of new PET/MR software algorithms, such as assessment of point-spread function-based reconstruction algorithms.

Microbiological assay of the Marshall Space Flight Center neutral buoyancy simulator

NASA Technical Reports Server (NTRS)

Beyerle, F. J.

1973-01-01

A neutral buoyancy simulator tank system is described in terms of microbiological and medical safety for astronauts. The system was designed to simulate a gravity-free state for evaluation of orbital operations in a microorganism-free environment. Methods for the identification and elimination of specific microorganisms are dealt with as measures for a pure system of space environment simulation.

Advanced Simulation in Undergraduate Pilot Training: Automatic Instructional System. Final Report for the Period March 1971-January 1975.

ERIC Educational Resources Information Center

Faconti, Victor; Epps, Robert

The Advanced Simulator for Undergraduate Pilot Training (ASUPT) was designed to investigate the role of simulation in the future Undergraduate Pilot Training (UPT) program. The Automated Instructional System designed for the ASUPT simulator was described in this report. The development of the Automated Instructional System for ASUPT was based upon…

COED Transactions, Vol. X, No. 10, October 1978. Simulation of a Sampled-Data System on a Hybrid Computer.

ERIC Educational Resources Information Center

Mitchell, Eugene E., Ed.

The simulation of a sampled-data system is described that uses a full parallel hybrid computer. The sampled data system simulated illustrates the proportional-integral-derivative (PID) discrete control of a continuous second-order process representing a stirred-tank. The stirred-tank is simulated using continuous analog components, while PID…

Advanced sensor-simulation capability

NASA Astrophysics Data System (ADS)

Cota, Stephen A.; Kalman, Linda S.; Keller, Robert A.

1990-09-01

This paper provides an overview of an advanced simulation capability currently in use for analyzing visible and infrared sensor systems. The software system, called VISTAS (VISIBLE/INFRARED SENSOR TRADES, ANALYSES, AND SIMULATIONS) combines classical image processing techniques with detailed sensor models to produce static and time dependent simulations of a variety of sensor systems including imaging, tracking, and point target detection systems. Systems modelled to date include space-based scanning line-array sensors as well as staring 2-dimensional array sensors which can be used for either imaging or point source detection.

Simulation Of Combat With An Expert System

NASA Technical Reports Server (NTRS)

Provenzano, J. P.

1989-01-01

Proposed expert system predicts outcomes of combat situations. Called "COBRA", combat outcome based on rules for attrition, system selects rules for mathematical modeling of losses and discrete events in combat according to previous experiences. Used with another software module known as the "Game". Game/COBRA software system, consisting of Game and COBRA modules, provides for both quantitative aspects and qualitative aspects in simulations of battles. COBRA intended for simulation of large-scale military exercises, concepts embodied in it have much broader applicability. In industrial research, knowledge-based system enables qualitative as well as quantitative simulations.

Spacecraft Multiple Array Communication System Performance Analysis

NASA Technical Reports Server (NTRS)

Hwu, Shian U.; Desilva, Kanishka; Sham, Catherine C.

2010-01-01

The Communication Systems Simulation Laboratory (CSSL) at the NASA Johnson Space Center is tasked to perform spacecraft and ground network communication system simulations, design validation, and performance verification. The CSSL has developed simulation tools that model spacecraft communication systems and the space and ground environment in which the tools operate. In this paper, a spacecraft communication system with multiple arrays is simulated. Multiple array combined technique is used to increase the radio frequency coverage and data rate performance. The technique is to achieve phase coherence among the phased arrays to combine the signals at the targeting receiver constructively. There are many technical challenges in spacecraft integration with a high transmit power communication system. The array combining technique can improve the communication system data rate and coverage performances without increasing the system transmit power requirements. Example simulation results indicate significant performance improvement can be achieved with phase coherence implementation.

Simulation of a Doppler lidar system for autonomous navigation and hazard avoidance during planetary landing

NASA Astrophysics Data System (ADS)

Budge, Scott E.; Chester, David B.

2016-05-01

The latest mission proposals for exploration of solar system bodies require accurate position and velocity data during the descent phase in order to ensure safe, soft landing at the pre-designated sites. During landing maneuvers, the accuracy of the on-board inertial measurement unit (IMU) may not be reliable due to drift over extended travel times to destinations. NASA has proposed an advanced Doppler lidar system with multiple beams that can be used to accurately determine attitude and position of the landing vehicle during descent, and to detect hazards that might exist in the landing area. In order to assess the effectiveness of such a Doppler lidar landing system, it is valuable to simulate the system with different beam numbers and configurations. In addition, the effectiveness of the system to detect and map potential landing hazards must be understood. This paper reports the simulated system performance for a proposed multi-beam Doppler lidar using the LadarSIM system simulation software. Details of the simulation methods are given, as well as lidar performance parameters such as range and velocity accuracy, detection and false alarm rates, and examples of the Doppler lidars ability to detect and characterize simulated hazards in the landing site. The simulation includes modulated pulse generation and coherent detection methods, beam footprint simulation, beam scanning, and interaction with terrain.

Enhanced TCAS 2/CDTI traffic Sensor digital simulation model and program description

NASA Technical Reports Server (NTRS)

Goka, T.

1984-01-01

Digital simulation models of enhanced TCAS 2/CDTI traffic sensors are developed, based on actual or projected operational and performance characteristics. Two enhanced Traffic (or Threat) Alert and Collision Avoidance Systems are considered. A digital simulation program is developed in FORTRAN. The program contains an executive with a semireal time batch processing capability. The simulation program can be interfaced with other modules with a minimum requirement. Both the traffic sensor and CAS logic modules are validated by means of extensive simulation runs. Selected validation cases are discussed in detail, and capabilities and limitations of the actual and simulated systems are noted. The TCAS systems are not specifically intended for Cockpit Display of Traffic Information (CDTI) applications. These systems are sufficiently general to allow implementation of CDTI functions within the real systems' constraints.

Continuous variable quantum optical simulation for time evolution of quantum harmonic oscillators

PubMed Central

Deng, Xiaowei; Hao, Shuhong; Guo, Hong; Xie, Changde; Su, Xiaolong

2016-01-01

Quantum simulation enables one to mimic the evolution of other quantum systems using a controllable quantum system. Quantum harmonic oscillator (QHO) is one of the most important model systems in quantum physics. To observe the transient dynamics of a QHO with high oscillation frequency directly is difficult. We experimentally simulate the transient behaviors of QHO in an open system during time evolution with an optical mode and a logical operation system of continuous variable quantum computation. The time evolution of an atomic ensemble in the collective spontaneous emission is analytically simulated by mapping the atomic ensemble onto a QHO. The measured fidelity, which is used for quantifying the quality of the simulation, is higher than its classical limit. The presented simulation scheme provides a new tool for studying the dynamic behaviors of QHO. PMID:26961962

The Loci Multidisciplinary Simulation System Overview and Status

NASA Technical Reports Server (NTRS)

Luke, Edward A.; Tong, Xiao-Ling; Tang, Lin

2002-01-01

This paper will discuss the Loci system, an innovative tool for developing tightly coupled multidisciplinary three dimensional simulations. This presentation will overview some of the unique capabilities of the Loci system to automate the assembly of numerical simulations from libraries of fundamental computational components. We will discuss the demonstration of the Loci system on coupled fluid-structure problems related to RBCC propulsion systems.

System-of-Systems Approach for Integrated Energy Systems Modeling and Simulation: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mittal, Saurabh; Ruth, Mark; Pratt, Annabelle

Today’s electricity grid is the most complex system ever built—and the future grid is likely to be even more complex because it will incorporate distributed energy resources (DERs) such as wind, solar, and various other sources of generation and energy storage. The complexity is further augmented by the possible evolution to new retail market structures that provide incentives to owners of DERs to support the grid. To understand and test new retail market structures and technologies such as DERs, demand-response equipment, and energy management systems while providing reliable electricity to all customers, an Integrated Energy System Model (IESM) is beingmore » developed at NREL. The IESM is composed of a power flow simulator (GridLAB-D), home energy management systems implemented using GAMS/Pyomo, a market layer, and hardware-in-the-loop simulation (testing appliances such as HVAC, dishwasher, etc.). The IESM is a system-of-systems (SoS) simulator wherein the constituent systems are brought together in a virtual testbed. We will describe an SoS approach for developing a distributed simulation environment. We will elaborate on the methodology and the control mechanisms used in the co-simulation illustrated by a case study.« less

Application of the Environmental Sensation Learning Vehicle Simulation Platform in Virtual Reality

ERIC Educational Resources Information Center

Hsu, Kuei-Shu; Jiang, Jinn-Feng; Wei, Hung-Yuan; Lee, Tsung-Han

2016-01-01

The use of simulation technologies in learning has received considerable attention in recent years, but few studies to date have focused on vehicle driving simulation systems. In this study, a vehicle driving simulation system was developed to support novice drivers in practicing their skills. Specifically, the vehicle driving simulation system…

Simulating the decentralized processes of the human immune system in a virtual anatomy model.

PubMed

Sarpe, Vladimir; Jacob, Christian

2013-01-01

Many physiological processes within the human body can be perceived and modeled as large systems of interacting particles or swarming agents. The complex processes of the human immune system prove to be challenging to capture and illustrate without proper reference to the spatial distribution of immune-related organs and systems. Our work focuses on physical aspects of immune system processes, which we implement through swarms of agents. This is our first prototype for integrating different immune processes into one comprehensive virtual physiology simulation. Using agent-based methodology and a 3-dimensional modeling and visualization environment (LINDSAY Composer), we present an agent-based simulation of the decentralized processes in the human immune system. The agents in our model - such as immune cells, viruses and cytokines - interact through simulated physics in two different, compartmentalized and decentralized 3-dimensional environments namely, (1) within the tissue and (2) inside a lymph node. While the two environments are separated and perform their computations asynchronously, an abstract form of communication is allowed in order to replicate the exchange, transportation and interaction of immune system agents between these sites. The distribution of simulated processes, that can communicate across multiple, local CPUs or through a network of machines, provides a starting point to build decentralized systems that replicate larger-scale processes within the human body, thus creating integrated simulations with other physiological systems, such as the circulatory, endocrine, or nervous system. Ultimately, this system integration across scales is our goal for the LINDSAY Virtual Human project. Our current immune system simulations extend our previous work on agent-based simulations by introducing advanced visualizations within the context of a virtual human anatomy model. We also demonstrate how to distribute a collection of connected simulations over a network of computers. As a future endeavour, we plan to use parameter tuning techniques on our model to further enhance its biological credibility. We consider these in silico experiments and their associated modeling and optimization techniques as essential components in further enhancing our capabilities of simulating a whole-body, decentralized immune system, to be used both for medical education and research as well as for virtual studies in immunoinformatics.

A New Simulation Framework for Autonomy in Robotic Missions

NASA Technical Reports Server (NTRS)

Flueckiger, Lorenzo; Neukom, Christian

2003-01-01

Autonomy is a key factor in remote robotic exploration and there is significant activity addressing the application of autonomy to remote robots. It has become increasingly important to have simulation tools available to test the autonomy algorithms. While indus1;rial robotics benefits from a variety of high quality simulation tools, researchers developing autonomous software are still dependent primarily on block-world simulations. The Mission Simulation Facility I(MSF) project addresses this shortcoming with a simulation toolkit that will enable developers of autonomous control systems to test their system s performance against a set of integrated, standardized simulations of NASA mission scenarios. MSF provides a distributed architecture that connects the autonomous system to a set of simulated components replacing the robot hardware and its environment.

Space lab system analysis

NASA Technical Reports Server (NTRS)

Rives, T. B.; Ingels, F. M.

1988-01-01

An analysis of the Automated Booster Assembly Checkout System (ABACS) has been conducted. A computer simulation of the ETHERNET LAN has been written. The simulation allows one to investigate different structures of the ABACS system. The simulation code is in PASCAL and is VAX compatible.

Traffic and Driving Simulator Based on Architecture of Interactive Motion.

PubMed

Paz, Alexander; Veeramisti, Naveen; Khaddar, Romesh; de la Fuente-Mella, Hanns; Modorcea, Luiza

2015-01-01

This study proposes an architecture for an interactive motion-based traffic simulation environment. In order to enhance modeling realism involving actual human beings, the proposed architecture integrates multiple types of simulation, including: (i) motion-based driving simulation, (ii) pedestrian simulation, (iii) motorcycling and bicycling simulation, and (iv) traffic flow simulation. The architecture has been designed to enable the simulation of the entire network; as a result, the actual driver, pedestrian, and bike rider can navigate anywhere in the system. In addition, the background traffic interacts with the actual human beings. This is accomplished by using a hybrid mesomicroscopic traffic flow simulation modeling approach. The mesoscopic traffic flow simulation model loads the results of a user equilibrium traffic assignment solution and propagates the corresponding traffic through the entire system. The microscopic traffic flow simulation model provides background traffic around the vicinities where actual human beings are navigating the system. The two traffic flow simulation models interact continuously to update system conditions based on the interactions between actual humans and the fully simulated entities. Implementation efforts are currently in progress and some preliminary tests of individual components have been conducted. The implementation of the proposed architecture faces significant challenges ranging from multiplatform and multilanguage integration to multievent communication and coordination.

Traffic and Driving Simulator Based on Architecture of Interactive Motion

PubMed Central

Paz, Alexander; Veeramisti, Naveen; Khaddar, Romesh; de la Fuente-Mella, Hanns; Modorcea, Luiza

2015-01-01

This study proposes an architecture for an interactive motion-based traffic simulation environment. In order to enhance modeling realism involving actual human beings, the proposed architecture integrates multiple types of simulation, including: (i) motion-based driving simulation, (ii) pedestrian simulation, (iii) motorcycling and bicycling simulation, and (iv) traffic flow simulation. The architecture has been designed to enable the simulation of the entire network; as a result, the actual driver, pedestrian, and bike rider can navigate anywhere in the system. In addition, the background traffic interacts with the actual human beings. This is accomplished by using a hybrid mesomicroscopic traffic flow simulation modeling approach. The mesoscopic traffic flow simulation model loads the results of a user equilibrium traffic assignment solution and propagates the corresponding traffic through the entire system. The microscopic traffic flow simulation model provides background traffic around the vicinities where actual human beings are navigating the system. The two traffic flow simulation models interact continuously to update system conditions based on the interactions between actual humans and the fully simulated entities. Implementation efforts are currently in progress and some preliminary tests of individual components have been conducted. The implementation of the proposed architecture faces significant challenges ranging from multiplatform and multilanguage integration to multievent communication and coordination. PMID:26491711

A Systemic-Constructivist Approach to the Facilitation and Debriefing of Simulations and Games

ERIC Educational Resources Information Center

Kriz, Willy Christian

2010-01-01

This article introduces some basic concepts of a systemic-constructivist perspective. These show that gaming simulation corresponds closely to a systemic-constructivist approach to learning and instruction. Some quality aspects of facilitating and debriefing simulation games are described from a systemic-constructivist point of view. Finally, a…

Comparative Genomic Analysis of Nontuberculous Mycobacteria (NTM) and Environmental isolates associated with a Simulated Chloraminated Drinking Water Distribution System Subjected to Episodes of Nitrification

EPA Science Inventory

Bacterial populations were examined in a simulated chloraminated drinking water distribution system. After six months of continuous operation, coupons were incubated in CDC reactors receiving water from the simulated system to study biofilm development. The distribution system ...

Gaming-simulation and health education an overview.

PubMed

Greenblat, C S

1977-01-01

Simulation entails abstraction and representation from a larger system in terms of process as well as structure. Central features are identified and simplified, less important elements are omitted from the model. In medical and health education, simulation enables learners to practice in an environment where mistakes are not costly, such as with simulated patients. Gaming-simulation incorporates role-playing into a defined system of interaction simulating a real world system and is characterized by the degree of structure of the roles and the focus on role interactions. Employment of gaming-simulation is embryonic in health education. Examples included in this Monograph concern problems of aging, hemophiliacs, and the dying; teaching interpersonal skills in psychiatric nursing; interactions of health care systems with their communities; and several other topics. Evaluation is discussed in a separate paper. A variety of health care gaming resources are described.

Minimizing a Wireless Passive LC-Tank Sensor to Monitor Bladder Pressure: A Simulation Study.

PubMed

Melgaard, Jacob; Struijk, Johannes J; Rijkhoff, Nico J M

2017-01-01

In this simulation study, a wireless passive LC-tank sensor system was characterized. Given the application of continuous bladder monitoring, a specific system was proposed in terms of coil geometries and electronic circuitry. Coupling coefficients were spatially mapped by simulation, as a function of both coil distance, and longitudinal and transverse translation of the sensor relative to the antenna. Further, two interrogation schemes were outlined. One was an auto-balancing bridge for computing the sensor-system impedance. In this case, the theoretical noise limit of the analogue part of the system was found by simulations. As the full system is not necessary for obtaining a pressure reading from the sensor, a simplified circuit more suited for an implantable system was deduced. For this system, both the analogue and digital parts were simulated. First, the required ADC resolution for operating the system at a given coupling was found by simulations in the noise-free case. Then, for one selected typical operational point, noise was added gradually, and through Monte-Carlo type simulations, the system performance was obtained. Combining these results, it was found that it at least is possible to operate the proposed system for distances up to 12 mm, or equivalently for coupling coefficients above 0.005. In this case a 14 bit ADC is required, and a carrier SNR of 27 dB can be tolerated.

Simulation of salt production process

NASA Astrophysics Data System (ADS)

Muraveva, E. A.

2017-10-01

In this paper an approach to the use of simulation software iThink to simulate the salt production system has been proposed. The dynamic processes of the original system are substituted by processes simulated in the abstract model, but in compliance with the basic rules of the original system, which allows one to accelerate and reduce the cost of the research. As a result, a stable workable simulation model was obtained that can display the rate of the salt exhaustion and many other parameters which are important for business planning.

A Java-Enabled Interactive Graphical Gas Turbine Propulsion System Simulator

NASA Technical Reports Server (NTRS)

Reed, John A.; Afjeh, Abdollah A.

1997-01-01

This paper describes a gas turbine simulation system which utilizes the newly developed Java language environment software system. The system provides an interactive graphical environment which allows the quick and efficient construction and analysis of arbitrary gas turbine propulsion systems. The simulation system couples a graphical user interface, developed using the Java Abstract Window Toolkit, and a transient, space- averaged, aero-thermodynamic gas turbine analysis method, both entirely coded in the Java language. The combined package provides analytical, graphical and data management tools which allow the user to construct and control engine simulations by manipulating graphical objects on the computer display screen. Distributed simulations, including parallel processing and distributed database access across the Internet and World-Wide Web (WWW), are made possible through services provided by the Java environment.

High performance computing in biology: multimillion atom simulations of nanoscale systems

PubMed Central

Sanbonmatsu, K. Y.; Tung, C.-S.

2007-01-01

Computational methods have been used in biology for sequence analysis (bioinformatics), all-atom simulation (molecular dynamics and quantum calculations), and more recently for modeling biological networks (systems biology). Of these three techniques, all-atom simulation is currently the most computationally demanding, in terms of compute load, communication speed, and memory load. Breakthroughs in electrostatic force calculation and dynamic load balancing have enabled molecular dynamics simulations of large biomolecular complexes. Here, we report simulation results for the ribosome, using approximately 2.64 million atoms, the largest all-atom biomolecular simulation published to date. Several other nanoscale systems with different numbers of atoms were studied to measure the performance of the NAMD molecular dynamics simulation program on the Los Alamos National Laboratory Q Machine. We demonstrate that multimillion atom systems represent a 'sweet spot' for the NAMD code on large supercomputers. NAMD displays an unprecedented 85% parallel scaling efficiency for the ribosome system on 1024 CPUs. We also review recent targeted molecular dynamics simulations of the ribosome that prove useful for studying conformational changes of this large biomolecular complex in atomic detail. PMID:17187988

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Digital instrumentation and controls system technique is being introduced in new constructed research reactor or life extension of older research reactor. Digital systems are easy to change and optimize but the validated process for them is required. Also, to reduce project risk or cost, we have to make it sure that configuration and control functions is right before the commissioning phase on research reactor. For this purpose, simulators have been widely used in developing control systems in automotive and aerospace industries. In these literatures, however, very few of these can be found regarding test on the control system of researchmore » reactor with simulator. Therefore, this paper proposes a simulation platform to verify the performance of RRS (Reactor Regulating System) for research reactor. This simulation platform consists of the reactor simulation model and the interface module. This simulation platform is applied to I and C upgrade project of TRIGA reactor, and many problems of RRS configuration were found and solved. And it proved that the dynamic performance testing based on simulator enables significant time saving and improves economics and quality for RRS in the system test phase. (authors)« less