The Segmented Aperture Interferometric Nulling Testbed (SAINT) I: overview and air-side system description

NASA Astrophysics Data System (ADS)

Hicks, Brian A.; Lyon, Richard G.; Petrone, Peter; Ballard, Marlin; Bolcar, Matthew R.; Bolognese, Jeff; Clampin, Mark; Dogoda, Peter; Dworzanski, Daniel; Helmbrecht, Michael A.; Koca, Corina; Shiri, Ron

2016-07-01

This work presents an overview of the Segmented Aperture Interferometric Nulling Testbed (SAINT), a project that will pair an actively-controlled macro-scale segmented mirror with the Visible Nulling Coronagraph (VNC). SAINT will incorporate the VNC's demonstrated wavefront sensing and control system to refine and quantify end-to-end high-contrast starlight suppression performance. This pathfinder testbed will be used as a tool to study and refine approaches to mitigating instabilities and complex diffraction expected from future large segmented aperture telescopes.

The a priori SDR Estimation Techniques with Reduced Speech Distortion for Acoustic Echo and Noise Suppression

NASA Astrophysics Data System (ADS)

Thoonsaengngam, Rattapol; Tangsangiumvisai, Nisachon

This paper proposes an enhanced method for estimating the a priori Signal-to-Disturbance Ratio (SDR) to be employed in the Acoustic Echo and Noise Suppression (AENS) system for full-duplex hands-free communications. The proposed a priori SDR estimation technique is modified based upon the Two-Step Noise Reduction (TSNR) algorithm to suppress the background noise while preserving speech spectral components. In addition, a practical approach to determine accurately the Echo Spectrum Variance (ESV) is presented based upon the linear relationship assumption between the power spectrum of far-end speech and acoustic echo signals. The ESV estimation technique is then employed to alleviate the acoustic echo problem. The performance of the AENS system that employs these two proposed estimation techniques is evaluated through the Echo Attenuation (EA), Noise Attenuation (NA), and two speech distortion measures. Simulation results based upon real speech signals guarantee that our improved AENS system is able to mitigate efficiently the problem of acoustic echo and background noise, while preserving the speech quality and speech intelligibility.

Mitigation of radiation-induced hematopoietic injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice

PubMed Central

Venkateswaran, Kavya; Shrivastava, Anju; Agrawala, Paban K.; Prasad, Ashok; Kalra, Namita; Pandey, Parvat R.; Manda, Kailash; Raj, Hanumantharao G.; Parmar, Virinder S.; Dwarakanath, Bilikere S.

2016-01-01

Protection of the hematopoietic system from radiation damage, and/or mitigation of hematopoietic injury are the two major strategies for developing medical countermeasure agents (MCM) to combat radiation-induced lethality. In the present study, we investigated the potential of 7, 8-diacetoxy-4-methylthiocoumarin (DAMTC) to ameliorate radiation-induced hematopoietic damage and the associated mortality following total body irradiation (TBI) in C57BL/6 mice. Administration of DAMTC 24 hours post TBI alleviated TBI-induced myelo-suppression and pancytopenia, by augmenting lymphocytes and WBCs in the peripheral blood of mice, while bone marrow (BM) cellularity was restored through enhanced proliferation of the stem cells. It stimulated multi-lineage expansion and differentiation of myeloid progenitors in the BM and induced proliferation of splenic progenitors thereby, facilitating hematopoietic re-population. DAMTC reduced the radiation-induced apoptotic and mitotic death in the hematopoietic compartment. Recruitment of pro-inflammatory M1 macrophages in spleen contributed to the immune-protection linked to the mitigation of hematopoietic injury. Recovery of the hematopoietic compartment correlated well with mitigation of mortality at a lethal dose of 9 Gy, leading to 80% animal survival. Present study establishes the potential of DAMTC to mitigate radiation-induced injury to the hematopoietic system by stimulating the re-population of stem cells from multiple lineages. PMID:27849061

Forest fire management to avoid unintended consequences: a case study of Portugal using system dynamics.

PubMed

Collins, Ross D; de Neufville, Richard; Claro, João; Oliveira, Tiago; Pacheco, Abílio P

2013-11-30

Forest fires are a serious management challenge in many regions, complicating the appropriate allocation to suppression and prevention efforts. Using a System Dynamics (SD) model, this paper explores how interactions between physical and political systems in forest fire management impact the effectiveness of different allocations. A core issue is that apparently sound management can have unintended consequences. An instinctive management response to periods of worsening fire severity is to increase fire suppression capacity, an approach with immediate appeal as it directly treats the symptom of devastating fires and appeases the public. However, the SD analysis indicates that a policy emphasizing suppression can degrade the long-run effectiveness of forest fire management. By crowding out efforts to preventative fuel removal, it exacerbates fuel loads and leads to greater fires, which further balloon suppression budgets. The business management literature refers to this problem as the firefighting trap, wherein focus on fixing problems diverts attention from preventing them, and thus leads to inferior outcomes. The paper illustrates these phenomena through a case study of Portugal, showing that a balanced approach to suppression and prevention efforts can mitigate the self-reinforcing consequences of this trap, and better manage long-term fire damages. These insights can help policymakers and fire managers better appreciate the interconnected systems in which their authorities reside and the dynamics that may undermine seemingly rational management decisions. Copyright © 2013 Elsevier Ltd. All rights reserved.

Designing advanced biochar products for maximizing greenhouse gas mitigation potential

USDA-ARS?s Scientific Manuscript database

Greenhouse gas (GHG) emissions from agricultural operations continue to increase. Carbon enriched char materials like biochar have been described as a mitigation strategy. Utilization of biochar material as a soil amendment has been demonstrated to provide potentially further soil GHG suppression du...

The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice.

PubMed

Goldman, Devorah C; Alexeev, Vitali; Lash, Elizabeth; Guha, Chandan; Rodeck, Ulrich; Fleming, William H

2015-03-01

Bone marrow suppression due to exposure to ionizing radiation is a significant clinical problem associated with radiation therapy as well as with nonmedical radiation exposure. Currently, there are no small molecule agents available that can enhance hematopoietic regeneration after radiation exposure. Here, we report on the effective mitigation of acute hematopoietic radiation syndrome in mice by the synthetic triterpenoid, RTA 408. The administration of a brief course of RTA 408 treatment, beginning 24 h after lethal doses of radiation to bone marrow, significantly increased overall survival. Importantly, treatment with RTA 408 led to the full recovery of steady state hematopoiesis with normalization of the frequency of hematopoietic stem and progenitor cells. Moreover, hematopoietic stem cells from RTA 408-mitigated mice showed lineage-balanced, long-term, multilineage potential in serial transplantation assays, indicative of their normal self-renewal activity. The potency of RTA 408 in mitigating radiation-induced bone marrow suppression makes it an attractive candidate for potential clinical use in treating both therapy-related and unanticipated radiation exposure.

Hazardous fuel treatments, suppression cost impacts, and risk mitigation

Treesearch

Matthew P. Thompson; Michael S. Hand; Julie W. Gilbertson-Day; Nicole M. Vaillant; Darek J. Nalle

2013-01-01

Land management agencies face uncertain tradeoffs regarding investments in preparedness and fuels management versus future suppression costs and impacts to valued resources and assets. Prospective evaluation of fuel treatments allows for comparison of alternative treatment strategies in terms of socioeconomic and ecological impacts, and can facilitate tradeoff analysis...

Animal and pasture responses to grazing management of chemically suppressed tall fescue in mixed pastures

USDA-ARS?s Scientific Manuscript database

Treatment of toxic endophyte-infected tall fescue [Lolium arundinaceum (Schreb.) Darbysh] with metsulfuran-methyl can mitigate fescue toxicosis and enhance forage nutritive value by suppressing seedhead emergence. A grazing experiment was conducted with steers (2013) and heifers (2014) to evaluate a...

Suppressing ghost beams: Backlink options for LISA

NASA Astrophysics Data System (ADS)

Isleif, K.-S.; Gerberding, O.; Penkert, D.; Fitzsimons, E.; Ward, H.; Robertson, D.; Livas, J.; Mueller, G.; Reiche, J.; Heinzel, G.; Danzmann, K.

2017-05-01

In this article we discuss possible design options for the optical phase reference system, the so called backlink, between two moving optical benches in a LISA satellite. The candidates are based on two approaches: Fiber backlinks, with additional features like mode cleaning cavities and Faraday isolators, and free beam backlinks with angle compensation techniques. We will indicate dedicated ghost beam mitigation strategies for the design options and we will point out critical aspects in case of an implementation in LISA.

Development of a Crosstalk Suppression Algorithm for KID Readout

NASA Astrophysics Data System (ADS)

Lee, Kyungmin; Ishitsuka, H.; Oguri, S.; Suzuki, J.; Tajima, O.; Tomita, N.; Won, Eunil; Yoshida, M.

2018-06-01

The GroundBIRD telescope aims to detect B-mode polarization of the cosmic microwave background radiation using the kinetic inductance detector array as a polarimeter. For the readout of the signal from detector array, we have developed a frequency division multiplexing readout system based on a digital down converter method. These techniques in general have the leakage problems caused by the crosstalks. The window function was applied in the field programmable gate arrays to mitigate the effect of these problems and tested it in algorithm level.

Suppressing tin whisker growth in lead-free solders and platings

DOEpatents

Hoffman, Elizabeth N; Lam, Poh-Sang

2014-04-29

A process of irradiation Sn containing Pb-free solder to mitigate whisker formation and growth thereon is provided. The use of gamma radiation such as cobalt-60 has been applied to a substrate of Sn on copper has been found to change the morphology of the crystalline whisker growth to a more truncated hillock pattern. The change in morphology greatly reduces the tendency of whiskers to contribute to electrical short-circuits being used as a Pb-free solder system on a copper substrate.

Fighting fire with fire: estimating the efficacy of wildfire mitigation programs using propensity scores

Treesearch

David T. Butry

2009-01-01

This paper examines the effect wildfire mitigation has on broad-scale wildfire behavior. Each year, hundreds of million of dollars are spent on fire suppression and fuels management applications, yet little is known, quantitatively, of the returns to these programs in terms of their impact on wildfire extent and intensity. This is especially true when considering that...

Cumulative watershed effects of fuel management in the western United States

Treesearch

William J. Elliot; Ina Sue Miller; Lisa Audin

2010-01-01

Fire suppression in the last century has resulted in forests with excessive amounts of biomass, leading to more severe wildfires, covering greater areas, requiring more resources for suppression and mitigation, and causing increased onsite and offsite damage to forests and watersheds. Forest managers are now attempting to reduce this accumulated biomass by thinning,...

MIMO-OFDM signal optimization for SAR imaging radar

NASA Astrophysics Data System (ADS)

Baudais, J.-Y.; Méric, S.; Riché, V.; Pottier, É.

2016-12-01

This paper investigates the optimization of the coded orthogonal frequency division multiplexing (OFDM) transmitted signal in a synthetic aperture radar (SAR) context. We propose to design OFDM signals to achieve range ambiguity mitigation. Indeed, range ambiguities are well known to be a limitation for SAR systems which operates with pulsed transmitted signal. The ambiguous reflected signal corresponding to one pulse is then detected when the radar has already transmitted the next pulse. In this paper, we demonstrate that the range ambiguity mitigation is possible by using orthogonal transmitted wave as OFDM pulses. The coded OFDM signal is optimized through genetic optimization procedures based on radar image quality parameters. Moreover, we propose to design a multiple-input multiple-output (MIMO) configuration to enhance the noise robustness of a radar system and this configuration is mainly efficient in the case of using orthogonal waves as OFDM pulses. The results we obtain show that OFDM signals outperform conventional radar chirps for range ambiguity suppression and for robustness enhancement in 2 ×2 MIMO configuration.

Trying not to get burned: Understanding homeowners' wildfire risk-mitigation behaviors

Treesearch

Hannah Brenkert-Smith; Patricia A. Champ; Nicholas Flores

2012-01-01

Three causes have been identified for the spiraling cost of wildfire suppression in the United States: climate change, fuel accumulation from past wildfire suppression, and development in fire-prone areas. Because little is likely to be performed to halt the effects of climate on wildfire risk, and because fuel-management budgets cannot keep pace with fuel accumulation...

In-Flight Suppression of a De-Stabilized F/A-18 Structural Mode Using the Space Launch System Adaptive Augmenting Control System

NASA Technical Reports Server (NTRS)

Wall, John; VanZwieten, Tannen; Giiligan Eric; Miller, Chris; Hanson, Curtis; Orr, Jeb

2015-01-01

Adaptive Augmenting Control (AAC) has been developed for NASA's Space Launch System (SLS) family of launch vehicles and implemented as a baseline part of its flight control system (FCS). To raise the technical readiness level of the SLS AAC algorithm, the Launch Vehicle Adaptive Control (LVAC) flight test program was conducted in which the SLS FCS prototype software was employed to control the pitch axis of Dryden's specially outfitted F/A-18, the Full Scale Advanced Systems Test Bed (FAST). This presentation focuses on a set of special test cases which demonstrate the successful mitigation of the unstable coupling of an F/A-18 airframe structural mode with the SLS FCS.

Suppression of Adverse Effects of GIC Using Controlled Variable Grounding Resistor

NASA Astrophysics Data System (ADS)

Abuhussein, A.; Ali, M. H.

2016-12-01

Geomagnetically induced current (GIC) has a harmful impact on power systems, with a large footprint. Mitigation strategies for the GIC are required to protect the integrity of the power system. To date, the adverse effects of GIC are being mitigated by either operational procedures or grounding fixed capacitors (GFCs). The operational procedures are uncertain, reduce systems' reliability, and increase energy losses. On the other hand, GFCs, incur voltage spikes, increase the transformer cost substantially, and require protection circuitry. This study investigates new possible approaches to cope with GIC, by using a controlled variable grounding resistor (CVGR), without interfering with the system's normal operation. In addition, the new techniques help suppress unsymmetrical faults in the power network. The controllability of the grounding resistor is applied using three different techniques: (1) a Parallel switch that is controlled by PI regulated duty cycle, (2) a Parallel switch that is triggered by a preset values in a look-up-table (LUT), and (3) a Mechanical resistor varied by a Fuzzy logic controller (FLC). The experimental results were obtained and validated using the MATLAB/SIMULINK software. A hypothetical power system that consists of a generator, a 765kv, 500 km long transmission lines connecting between a step-up, Δ-Yn, transformer, and a step-down, Yn-Δ, transformer, is considered. The performance of the CVGR is compared with that of the GFC under the cases of GIC event and unsymmetrical faults. From the simulation results, the following points are concluded: The CVGR effectively suppresses the GIC flowing in the system. Consequently, it protects the transformers from saturation and the rest of the system from collapsing. The CVGR also reduces the voltage and power swings associated with unsymmetrical faults and blocks the zero sequence current flowing through the neutral of the transformer. The performance of the CVGR surpasses that of the GFC in terms of GIC/fault current magnitude and decay time reduction. The GFC violates the IEEE standards C57.32/ C57.12 of transformers insulation level, while the CVGR maintain the neutral to ground voltage within acceptable levels. The CVGR, as opposed to the GFC, does not require a discharge circuit (spark gap), thus it reduces the cost and complexity.

Hungry Horse Mitigation; Flathead Lake, 2003-2004 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, Barry; Evarts, Les

2005-06-01

The Confederated Salish and Kootenai Tribes (CSKT) and Montana Fish Wildlife and Parks (MFWP) wrote the ''Fisheries Mitigation Plan for Losses Attributable to the Construction and Operation of Hungry Horse Dam'' in March 1991 to define the fisheries losses, mitigation alternatives and recommendations to protect, mitigate and enhance resident fish and aquatic habitat affected by Hungry Horse Dam. On November 12, 1991, the Northwest Power Planning Council (NPPC) approved the mitigation plan with minor modifications, called for a detailed implementation plan, and amended measures 903(h)(1) through (7). A long-term mitigation plan was submitted in August 1992, was approved by themore » Council in 1993, and the first contract for this project was signed on November 11, 1993. The problem this project addresses is the loss of habitat, both in quality and quantity, in the Flathead Lake and River basin resulting from the construction and operation of Hungry Horse Dam. The purpose of the project is to both implement mitigation measures and monitor the biological responses to those measures including those implemented by Project Numbers 9101903 and 9101904. Goals and objectives of the 1994 Fish and Wildlife Program (Section 10.1) addressed by this project are the rebuilding to sustainable levels weak, but recoverable, native populations injured by the hydropower system. The project mitigates the blockage of spawning runs by Hungry Horse Dam by restoring and even creating spawning habitats within direct drainages to Flathead Lake. The project also addresses the altered habitat within Flathead Lake resulting from species shifts and consequent dominance of new species that restricts the potential success of mitigation measures. Specific goals of this project are to create and restore habitat and quantitatively monitor changes in fish populations to verify the efficacy of our mitigation measures. The project consists of three components: monitoring, restoration and research. Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Objective 1 in the workplan is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of Objectives 2-8.« less

Hungry Horse Mitigation : Flathead Lake : Annual Progress Report 2007.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, Barry; Evarts, Les

2008-12-22

The Confederated Salish and Kootenai Tribes (CSKT) and Montana Fish Wildlife and Parks (MFWP) wrote the 'Fisheries Mitigation Plan for Losses Attributable to the Construction and Operation of Hungry Horse Dam' in March 1991 to define the fisheries losses, mitigation alternatives and recommendations to protect, mitigate and enhance resident fish and aquatic habitat affected by Hungry Horse Dam. On November 12, 1991, the Northwest Power Planning Council (NPPC) approved the mitigation plan with minor modifications, called for a detailed implementation plan, and amended measures 903(h)(1) through (7). A long-term mitigation plan was submitted in August 1992, was approved by themore » Council in 1993, and the first contract for this project was signed on November 11, 1993. The problem this project addresses is the loss of habitat, both in quality and quantity, in the Flathead Lake and River basin resulting from the construction and operation of Hungry Horse Dam. The purpose of the project is to both implement mitigation measures and monitor the biological responses to those measures including those implemented by Project Numbers 9101903 and 9101904. Goals and objectives of the 1994 Fish and Wildlife Program (Section 10.1) addressed by this project are the rebuilding to sustainable levels weak, but recoverable, native populations injured by the hydropower system. The project mitigates the blockage of spawning runs by Hungry Horse Dam by restoring and even creating spawning habitats within direct drainages to Flathead Lake. The project also addresses the altered habitat within Flathead Lake resulting from species shifts and consequent dominance of new species that restricts the potential success of mitigation measures. Specific goals of this project are to create and restore habitat and quantitatively monitor changes in fish populations to verify the efficacy of our mitigation measures. The project consists of three components: monitoring, restoration and research. Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Work Element A in the Statement of Work is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of all remaining Work Elements.« less

Hungry Horse Mitigation; Flathead Lake, 2004-2005 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, Barry; Evarts, Les

2006-06-01

The Confederated Salish and Kootenai Tribes (CSKT) and Montana Fish Wildlife and Parks (MFWP) wrote the ''Fisheries Mitigation Plan for Losses Attributable to the Construction and Operation of Hungry Horse Dam'' in March 1991 to define the fisheries losses, mitigation alternatives and recommendations to protect, mitigate and enhance resident fish and aquatic habitat affected by Hungry Horse Dam. On November 12, 1991, the Northwest Power Planning Council (NPPC) approved the mitigation plan with minor modifications, called for a detailed implementation plan, and amended measures 903(h)(1) through (7). A long-term mitigation plan was submitted in August 1992, was approved by themore » Council in 1993, and the first contract for this project was signed on November 11, 1993. The problem this project addresses is the loss of habitat, both in quality and quantity, in the Flathead Lake and River basin resulting from the construction and operation of Hungry Horse Dam. The purpose of the project is to both implement mitigation measures and monitor the biological responses to those measures including those implemented by Project Numbers 9101903 and 9101904. Goals and objectives of the 1994 Fish and Wildlife Program (Section 10.1) addressed by this project are the rebuilding to sustainable levels weak, but recoverable, native populations injured by the hydropower system. The project mitigates the blockage of spawning runs by Hungry Horse Dam by restoring and even creating spawning habitats within direct drainages to Flathead Lake. The project also addresses the altered habitat within Flathead Lake resulting from species shifts and consequent dominance of new species that restricts the potential success of mitigation measures. Specific goals of this project are to create and restore habitat and quantitatively monitor changes in fish populations to verify the efficacy of our mitigation measures. The project consists of three components: monitoring, restoration and research. Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Work Element A in the Statement of Work is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of all remaining Work Elements.« less

Hungry Horse Mitigation : Flathead Lake : Annual Progress Report 2008.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, Barry; Evarts, Les

2009-08-06

The Confederated Salish and Kootenai Tribes (CSKT) and Montana Fish Wildlife and Parks (MFWP) wrote the 'Fisheries Mitigation Plan for Losses Attributable to the Construction and Operation of Hungry Horse Dam' in March 1991 to define the fisheries losses, mitigation alternatives and recommendations to protect, mitigate and enhance resident fish and aquatic habitat affected by Hungry Horse Dam. On November 12, 1991, the Northwest Power Planning Council (NPPC) approved the mitigation plan with minor modifications, called for a detailed implementation plan, and amended measures 903(h)(1) through (7). A long-term mitigation plan was submitted in August 1992, was approved by themore » Council in 1993, and the first contract for this project was signed on November 11, 1993. The problem this project addresses is the loss of habitat, both in quality and quantity, in the Flathead Lake and River basin resulting from the construction and operation of Hungry Horse Dam. The purpose of the project is to both implement mitigation measures and monitor the biological responses to those measures including those implemented by Project Numbers 9101903 and 9101904. Goals and objectives of the 1994 Fish and Wildlife Program (Section 10.1) addressed by this project are the rebuilding to sustainable levels weak, but recoverable, native populations injured by the hydropower system. The project mitigates the blockage of spawning runs by Hungry Horse Dam by restoring and even creating spawning habitats within direct drainages to Flathead Lake. The project also addresses the altered habitat within Flathead Lake resulting from species shifts and consequent dominance of new species that restricts the potential success of mitigation measures. Specific goals of this project are to create and restore habitat and quantitatively monitor changes in fish populations to verify the efficacy of our mitigation measures. The project consists of three components: monitoring, restoration and research. Monitoring, for example, includes a spring gillnetting series conducted annually in Flathead Lake and builds on an existing data set initiated in 1981. Monitoring of the experimental kokanee reintroduction was a primary activity of this project between 1992 and 1997. Lake trout, whose high densities have precluded successful mitigation of losses of other species in Flathead Lake, have been monitored since 1996 to measure several biological parameters. Results of this work have utility in determining the population status of this key predator in Flathead Lake. The project has also defined the baseline condition of the Flathead Lake fishery in 1992-1993 and has conducted annual lakewide surveys since 1998. The restoration component of the project has addressed several stream channel, riparian, and fish passage problems, and suppression of non-native fish. The research component of the project began in FY 2000 and measured trophic linkages between M. relicta and other species to assist in predicting the results of our efforts to suppress lake trout. Only Work Element A in the Statement of Work is funded entirely by Hungry Horse Mitigation funds. Additional funds are drawn from other sources to assist in completion of all remaining Work Elements.« less

Pilot testing and protocol development of giant applesnail suppression at Mandalay National Wildlife Refuge, Louisiana—July–October 2017

USGS Publications Warehouse

Carter, Jacoby; Merino, Sergio

2018-03-19

This report provides an overview of the pilot study and description of the techniques developed for a future mitigation study of Pomacea maculata (giant applesnail) at the U.S. Fish and Wildlife Service Mandalay National Wildlife Refuge, Louisiana (MNWR). Egg mass suppression is a potential strategy for the mitigation of the invasive giant applesnail. In previous studies at Langan Municipal Park in Mobile, Alabama (LMP), and National Park Service Jean Lafitte National Park-Barataria Unit, Louisiana (JLNP), we determined that spraying food-grade oil (coconut oil or Pam™ spray) on egg masses significantly reduced egg hatching. At JLNP we also developed methods to estimate snail population size. The purpose of this pilot study was to adapt techniques developed for previous studies to the circumstances of MNWR in preparation for a larger experiment whereby we will test the effectiveness of egg mass suppression as an applesnail mitigation tool. We selected four canals that will be used as treatment and control sites for the experiment (two each). We established that an efficient way to destroy egg masses is to knock them down with a high-velocity stream of water pumped directly from the canal. The traps used at JLNP had to be modified to accommodate the greater range of water-level fluctuation at MNWR. One of the three marking methods used at JLNP was selected for use at MNWR.

Loss of DHR sequences at Browns Ferry Unit One - accident-sequence analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, D.H.; Grene, S.R.; Harrington, R.M.

1983-05-01

This study describes the predicted response of Unit One at the Browns Ferry Nuclear Plant to a postulated loss of decay heat removal (DHR) capability following scram from full power with the power conversion system unavailable. In accident sequences without DHR capability, the residual heat removal (RHR) system functions of pressure suppression pool cooling and reactor vessel shutdown cooling are unavailable. Consequently, all decay heat energy is stored in the pressure suppression pool with a concomitant increase in pool temperature and primary containment pressure. With the assumption that DHR capability is not regained during the lengthy course of this accidentmore » sequence, the containment ultimately fails by overpressurization. Although unlikely, this catastrophic failure might lead to loss of the ability to inject cooling water into the reactor vessel, causing subsequent core uncovery and meltdown. The timing of these events and the effective mitigating actions that might be taken by the operator are discussed in this report.« less

Methane Explosion Mitigation in Coal Mines by Water Mist

NASA Astrophysics Data System (ADS)

Chikhradze, Nikoloz; Mataradze, Edgar; Chikhradze, Mikheil; Krauthammer, Ted; Mansurov, Zulkhair; Alyiev, Erhan

2017-12-01

Statistics shows that the majority of accidents with fatal outcome are caused by methane and/or coal dust explosion. This leads to assume that contemporary counter-explosion systems of various designs cannot be considered effective. Considering the growing threat of methane explosion in the coming years along with the development of deeper levels, the improvement of a system for protecting people in underground opening appears urgent. This paper focuses on technical solutions to be used in designing a protective system for minimizing the consequences of methane explosions in coalmines. The new protective system consists of three main modules: i) a high-speed shock wave suppression section; ii) a suppression section with a long-term action and iii) a system activating device. The shock wave suppressor contains a 200 litre volume water tank with a built-in gas generator and nozzles. It is activated after 12ms from the blast moment, the duration of discharge is 40 s. The suppression section with a long-term action contains a 2000 litre volume water tank, a high-pressure pump, a hydraulic accumulator, solenoid valves, and a system of pipes with built-in nozzles. It is activated after 4 s from the blast moment, the duration of discharge is 8 min. The activation device includes a detection block containing sensors, an emergency signal generation module, a signal transmission module, a signal receiving module and a power supply module. The system operates in a waiting mode and activates immediately upon the receipt of the start signal generated by the detector. The paper also addresses the preliminary results of the system prototype testing in the tunnel.

Assessing the Role and Impact of Geospatial Data for Wildland Fire Management Decisions

NASA Astrophysics Data System (ADS)

Klein, E. A.; Lev, S. M.

2016-12-01

The 2015 Wildland and Fire Science and Technology Task Force Final Report, produced by the National Science and Technology Council, Committee on Environment, Natural Resources, and Sustainability, Subcommittee on Disaster Reduction, highlighted the increasing frequency of large wildfires and the growing demand for science to inform critical resource decisions to manage, mitigate, respond to, and recover from wildland fires. Federal spending on fire suppression from 2005-2015 has more than doubled despite policy changes that prioritize the mitigation of fire risks through the use of fuel treatments, prescribed fire, and management of naturally occurring wildfires to protect life and property. Fire suppression policies over the last century have created forests primed for severe fire, and in the face of a changing climate, the benefits of re-introducing fire into once fire-resilient ecosystems are clear. There are a range of complex factors and regional variation associated with wildland fire risk that complicate our understanding and effective management of this hazard. Data derived from Earth-observing (EO) systems and networks are a crucial input for managers when making decisions about fire suppression and fuel management. EO data can also be used to develop pre- and post-fire metrics that can aid in the evaluating the effectiveness of wildland fire management decisions. A value-tree method for mapping the role of EO systems and networks in delivering societal benefit through key Federal objectives related to wildland fire management will be presented. The value-tree methodology utilizes input from subject matter experts to assess the availability and usability of data and data products and to evaluate the impact of individual EO data inputs for achieving wildland fire management objectives. The results provide a qualitative assessment of the value of the data for the objectives described and identify critical gaps and continuity issues associated with improvements to and continuous delivery of societal benefit.

Mitigating amphibian disease: strategies to maintain wild populations and control chytridiomycosis

PubMed Central

2011-01-01

Background Rescuing amphibian diversity is an achievable conservation challenge. Disease mitigation is one essential component of population management. Here we assess existing disease mitigation strategies, some in early experimental stages, which focus on the globally emerging chytrid fungus Batrachochytrium dendrobatidis. We discuss the precedent for each strategy in systems ranging from agriculture to human medicine, and the outlook for each strategy in terms of research needs and long-term potential. Results We find that the effects of exposure to Batrachochytrium dendrobatidis occur on a spectrum from transient commensal to lethal pathogen. Management priorities are divided between (1) halting pathogen spread and developing survival assurance colonies, and (2) prophylactic or remedial disease treatment. Epidemiological models of chytridiomycosis suggest that mitigation strategies can control disease without eliminating the pathogen. Ecological ethics guide wildlife disease research, but several ethical questions remain for managing disease in the field. Conclusions Because sustainable conservation of amphibians in nature is dependent on long-term population persistence and co-evolution with potentially lethal pathogens, we suggest that disease mitigation not focus exclusively on the elimination or containment of the pathogen, or on the captive breeding of amphibian hosts. Rather, successful disease mitigation must be context specific with epidemiologically informed strategies to manage already infected populations by decreasing pathogenicity and host susceptibility. We propose population level treatments based on three steps: first, identify mechanisms of disease suppression; second, parameterize epizootiological models of disease and population dynamics for testing under semi-natural conditions; and third, begin a process of adaptive management in field trials with natural populations. PMID:21496358

Aircraft Weather Mitigation for the Next Generation Air Transportation System

NASA Technical Reports Server (NTRS)

Stough, H. Paul, III

2007-01-01

Atmospheric effects on aviation are described by Mahapatra (1999) as including (1) atmospheric phenomena involving air motion - wind shear and turbulence; (2) hydrometeorological phenomena - rain, snow and hail; (3) aircraft icing; (4) low visibility; and (5) atmospheric electrical phenomena. Aircraft Weather Mitigation includes aircraft systems (e.g. airframe, propulsion, avionics, controls) that can be enacted (by a pilot, automation or hybrid systems) to suppress and/or prepare for the effects of encountered or unavoidable weather or to facilitate a crew operational decision-making process relative to weather. Aircraft weather mitigation can be thought of as a continuum (Figure 1) with the need to avoid all adverse weather at one extreme and the ability to safely operate in all weather conditions at the other extreme. Realistic aircraft capabilities fall somewhere between these two extremes. The capabilities of small general aviation aircraft would be expected to fall closer to the "Avoid All Adverse Weather" point, and the capabilities of large commercial jet transports would fall closer to the "Operate in All Weather Conditions" point. The ability to safely operate in adverse weather conditions is dependent upon the pilot s capabilities (training, total experience and recent experience), the airspace in which the operation is taking place (terrain, navigational aids, traffic separation), the capabilities of the airport (approach guidance, runway and taxiway lighting, availability of air traffic control), as well as the capabilities of the airplane. The level of mitigation may vary depending upon the type of adverse weather. For example, a small general aviation airplane may be equipped to operate "in the clouds" without outside visual references, but not be equipped to prevent airframe ice that could be accreted in those clouds.

Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice

PubMed Central

Wang, Bing; Tanaka, Kaoru; Morita, Akinori; Ninomiya, Yasuharu; Maruyama, Kouichi; Fujita, Kazuko; Hosoi, Yoshio; Nenoi, Mitsuru

2013-01-01

Previous in vitro and in vivo studies have shown that sodium orthovanadate (vanadate), an inorganic vanadium compound, could effectively suppress radiation-induced p53-mediated apoptosis via both transcription-dependent and transcription-independent pathways. As a potent radiation protector administered at a dose of 20 mg/kg body weight (20 mg/kg) prior to total body irradiation (TBI) by intra-peritoneal (ip) injection, it completely protected mice from hematopoietic syndrome and partially from gastrointestinal syndrome. In the present study, radiation mitigation effects from vanadate were investigated by ip injection of vanadate after TBI in mice. Results showed that a single administration of vanadate at a dose of 20 mg/kg markedly improved the 30-day survival rate and the peripheral blood hemogram, relieved bone marrow aplasia and decreased occurrence of the bone marrow micronucleated erythrocytes in the surviving animals. The dose reduction factor was 1.2 when a single dose of 20 mg/kg was administered 15 min after TBI in mice using the 30-day survival test as the endpoint. Results also showed that either doubling the vanadate dose (40 mg/kg) in a single administration or continuing the vanadate treatment (after a single administration at 20 mg/kg) from the following day at a dose of 5 mg/kg per day for 4 consecutive days further significantly improved the efficacy for rescuing bone marrow failure in the 30-day survival test. Taken together, these findings indicate that vanadate would be a potent mitigator suppressing the acute lethality (hematopoietic syndrome) and minimizing the detrimental effects (anhematopoiesis and delayed genotoxic effects) induced by TBI in mice. PMID:23349341

Apparatus for draining lower drywell pool water into suppresion pool in boiling water reactor

DOEpatents

Gluntz, Douglas M.

1996-01-01

An apparatus which mitigates temperature stratification in the suppression pool water caused by hot water drained into the suppression pool from the lower drywell pool. The outlet of a spillover hole formed in the inner bounding wall of the suppression pool is connected to and in flow communication with one end of piping. The inlet end of the piping is above the water level in the suppression pool. The piping is routed down the vertical downcomer duct and through a hole formed in the thin wall separating the downcomer duct from the suppression pool water. The piping discharge end preferably has an elevation at or near the bottom of the suppression pool and has a location in the horizontal plane which is removed from the point where the piping first emerges on the suppression pool side of the inner bounding wall of the suppression pool. This enables water at the surface of the lower drywell pool to flow into and be discharged at the bottom of the suppression pool.

Short- and long-term effects of fire on carbon in US dry temperate forest systems

USGS Publications Warehouse

Hurteau, Matthew D.; Brooks, Matthew L.

2011-01-01

Forests sequester carbon from the atmosphere, and in so doing can mitigate the effects of climate change. Fire is a natural disturbance process in many forest systems that releases carbon back to the atmosphere. In dry temperate forests, fires historically burned with greater frequency and lower severity than they do today. Frequent fires consumed fuels on the forest floor and maintained open stand structures. Fire suppression has resulted in increased understory fuel loads and tree density; a change in structure that has caused a shift from low- to high-severity fires. More severe fires, resulting in greater tree mortality, have caused a decrease in forest carbon stability. Fire management actions can mitigate the risk of high-severity fires, but these actions often require a trade-off between maximizing carbon stocks and carbon stability. We discuss the effects of fire on forest carbon stocks and recommend that managing forests on the basis of their specific ecologies should be the foremost goal, with carbon sequestration being an ancillary benefit. ?? 2011 by American Institute of Biological Sciences. All rights reserved.

Plasmon-Exciton Interactions Probed Using Spatial Coentrapment of Nanoparticles by Topological Singularities.

PubMed

Ackerman, Paul J; Mundoor, Haridas; Smalyukh, Ivan I; van de Lagemaat, Jao

2015-12-22

We study plasmon-exciton interaction by using topological singularities to spatially confine, selectively deliver, cotrap and optically probe colloidal semiconductor and plasmonic nanoparticles. The interaction is monitored in a single quantum system in the bulk of a liquid crystal medium where nanoparticles are manipulated and nanoconfined far from dielectric interfaces using laser tweezers and topological configurations containing singularities. When quantum dot-in-a-rod particles are spatially colocated with a plasmonic gold nanoburst particle in a topological singularity core, its fluorescence increases because blinking is significantly suppressed and the radiative decay rate increases by nearly an order of magnitude owing to the Purcell effect. We argue that the blinking suppression is the result of the radiative rate change that mitigates Auger recombination and quantum dot ionization, consequently reducing nonradiative recombination. Our work demonstrates that topological singularities are an effective platform for studying and controlling plasmon-exciton interactions.

Plasmon–Exciton Interactions Probed Using Spatial Coentrapment of Nanoparticles by Topological Singularities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackerman, Paul J.; Mundoor, Haridas; Smalyukh, Ivan I.

2015-12-22

We study plasmon-exciton interaction by using topological singularities to spatially confine, selectively deliver, cotrap and optically probe colloidal semiconductor and plasmonic nanoparticles. The interaction is monitored in a single quantum system in the bulk of a liquid crystal medium where nanoparticles are manipulated and nanoconfined far from dielectric interfaces using laser tweezers and topological configurations containing singularities. When quantum dot-in-a-rod particles are spatially colocated with a plasmonic gold nanoburst particle in a topological singularity core, its fluorescence increases because blinking is significantly suppressed and the radiative decay rate increases by nearly an order of magnitude owing to the Purcell effect.more » We argue that the blinking suppression is the result of the radiative rate change that mitigates Auger recombination and quantum dot ionization, consequently reducing nonradiative recombination. Our work demonstrates that topological singularities are an effective platform for studying and controlling plasmon-exciton interactions.« less

Beam combining and SBS suppression in white noise and pseudo-random modulated amplifiers

NASA Astrophysics Data System (ADS)

Anderson, Brian; Flores, Angel; Holten, Roger; Ehrenreich, Thomas; Dajani, Iyad

2015-03-01

White noise phase modulation (WNS) and pseudo-random binary sequence phase modulation (PRBS) are effective techniques for mitigation of nonlinear effects such as stimulated Brillouin scattering (SBS); thereby paving the way for higher power narrow linewidth fiber amplifiers. However, detailed studies comparing both coherent beam combination and the SBS suppression of these phase modulation schemes have not been reported. In this study an active fiber cutback experiment is performed comparing the enhancement factor of a PRBS and WNS broadened seed as a function of linewidth and fiber length. Furthermore, two WNS and PRBS modulated fiber lasers are coherently combined to measure and compare the fringe visibility and coherence length as a function of optical path length difference. Notably, the discrete frequency comb of PRBS modulation provides a beam combining re-coherence effect where the lasers periodically come back into phase. Significantly, this may reduce path length matching complexity in coherently combined fiber laser systems.

Dynamic Resource Allocation in Disaster Response: Tradeoffs in Wildfire Suppression

PubMed Central

Petrovic, Nada; Alderson, David L.; Carlson, Jean M.

2012-01-01

Challenges associated with the allocation of limited resources to mitigate the impact of natural disasters inspire fundamentally new theoretical questions for dynamic decision making in coupled human and natural systems. Wildfires are one of several types of disaster phenomena, including oil spills and disease epidemics, where (1) the disaster evolves on the same timescale as the response effort, and (2) delays in response can lead to increased disaster severity and thus greater demand for resources. We introduce a minimal stochastic process to represent wildfire progression that nonetheless accurately captures the heavy tailed statistical distribution of fire sizes observed in nature. We then couple this model for fire spread to a series of response models that isolate fundamental tradeoffs both in the strength and timing of response and also in division of limited resources across multiple competing suppression efforts. Using this framework, we compute optimal strategies for decision making scenarios that arise in fire response policy. PMID:22514605

A study on the achievable data rate in massive MIMO system

NASA Astrophysics Data System (ADS)

Salh, Adeeb; Audah, Lukman; Shah, Nor Shahida M.; Hamzah, Shipun A.

2017-09-01

The achievable high data rates depend on the ability of massive multi-input-multi-output (MIMO) for the fifth-generation (5G) cellular networks, where the massive MIMO systems can support very high energy and spectral efficiencies. A major challenge in mobile broadband networks is how to support the throughput in the future 5G, where the highlight of 5G expected to provide high speed internet for every user. The performance massive MIMO system increase with linear minimum mean square error (MMSE), zero forcing (ZF) and maximum ratio transmission (MRT) when the number of antennas increases to infinity, by deriving the closed-form approximation for achievable data rate expressions. Meanwhile, the high signal-to-noise ratio (SNR) can be mitigated by using MMSE, ZF and MRT, which are used to suppress the inter-cell interference signals between neighboring cells. The achievable sum rate for MMSE is improved based on the distributed users inside cell, mitigated the inter-cell interference caused when send the same signal by other cells. By contrast, MMSE is better than ZF in perfect channel state information (CSI) for approximately 20% of the achievable sum rate.

Suppression of low-frequency charge noise in superconducting resonators by surface spin desorption.

PubMed

de Graaf, S E; Faoro, L; Burnett, J; Adamyan, A A; Tzalenchuk, A Ya; Kubatkin, S E; Lindström, T; Danilov, A V

2018-03-20

Noise and decoherence due to spurious two-level systems located at material interfaces are long-standing issues for solid-state quantum devices. Efforts to mitigate the effects of two-level systems have been hampered by a lack of knowledge about their chemical and physical nature. Here, by combining dielectric loss, frequency noise and on-chip electron spin resonance measurements in superconducting resonators, we demonstrate that desorption of surface spins is accompanied by an almost tenfold reduction in the charge-induced frequency noise in the resonators. These measurements provide experimental evidence that simultaneously reveals the chemical signatures of adsorbed magnetic moments and highlights their role in generating charge noise in solid-state quantum devices.

Dynamic load mitigation using dissipative elastic metamaterials with multiple Maxwell-type oscillators

NASA Astrophysics Data System (ADS)

Alamri, Sagr; Li, Bing; Tan, K. T.

2018-03-01

Dissipative elastic metamaterials have attracted increased attention in recent times. This paper presents the development of a dissipative elastic metamaterial with multiple Maxwell-type resonators for stress wave attenuation. The mechanism of the dissipation effect on the vibration characteristics is systematically investigated by mass-spring-damper models with single and dual resonators. Based on the parameter optimization, it is revealed that a broadband wave attenuation region (stopping band) can be obtained by properly utilizing interactions from resonant motions and viscoelastic effects of the Maxwell-type oscillators. The relevant numerical verifications are conducted for various cases, and excellent agreement between the numerical and theoretical frequency response functions is shown. The design of this dissipative metamaterial system is further applied for dynamic load mitigation and blast wave attenuation. Moreover, the transient response in the continuum model is designed and analyzed for more robust design. By virtue of the bandgap merging effect induced by the Maxwell-type damper, the transient blast wave can be almost completely suppressed in the low frequency range. A significantly improved performance of the proposed dissipative metamaterials for stress wave mitigation is verified in both time and frequency domains.

A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin

PubMed Central

Doctrow, Susan R.; Lopez, Argelia; Schock, Ashley M.; Duncan, Nathan E.; Jourdan, Megan M.; Olasz, Edit B.; Moulder, John E.; Fish, Brian L.; Mäder, Marylou; Lazar, Jozef; Lazarova, Zelmira

2012-01-01

In the event of a radionuclear attack or nuclear accident, the skin would be the first barrier exposed to radiation, though skin injury can progress over days to years following exposure. Chronic oxidative stress has been implicated as being a potential contributor to the progression of delayed radiation-induced injury to skin and other organs. To examine the causative role of oxidative stress in delayed radiation-induced skin injury, including impaired wound healing, we tested a synthetic superoxide dismutase (SOD)/catalase mimetic, EUK-207, in a rat model of combined skin irradiation and wound injury. Administered systemically, beginning 48 h after irradiation, EUK-207 mitigated radiation dermatitis, suppressed indicators of tissue oxidative stress, and enhanced wound healing. Evaluation of gene expression in irradiated skin at 30 days after exposure revealed a significant upregulation of several key genes involved in detoxication of reactive oxygen and nitrogen species. This gene expression pattern was primarily reversed by EUK-207 therapy. These results demonstrate that oxidative stress plays a critical role in the progression of radiation-induced skin injury, and that the injury can be mitigated by appropriate antioxidant compounds administered 48 h after exposure. PMID:23190879

Suppression of Collisionless Magnetic Reconnection in Asymmetric Current Sheets

NASA Technical Reports Server (NTRS)

Liu, Yi-Hsin; Hesse, Michael

2016-01-01

Using fully kinetic simulations, we study the suppression of asymmetric reconnection in the limit where the diamagnetic drift speed >> Alfven speed and the magnetic shear angle is moderate. We demonstrate that the slippage between electrons and the magnetic flux mitigates the suppression and can even result in fast reconnection that lacks one of the outflow jets. Through comparing a case where the diamagnetic drift is supported by the temperature gradient with a companion case that has a density gradient instead, we identify a robust suppression mechanism. The drift of the x-line is slowed down locally by the asymmetric nature of the x-line, and then the x-line is run over and swallowed by the faster-moving following flux.

Mitigation of Subsynchronous Resonance with Fractional-order PI based UPFC controller

NASA Astrophysics Data System (ADS)

Raju, D. Koteswara; Umre, Bhimrao S.; Junghare, Anjali S.; Babu, B. Chitti

2017-02-01

Due to incorporation of series capacitor compensation in transmission line for stability improvement, subsynchronous oscillations are generated at turbine-generator shaft. These oscillations can damage the shaft system if these are not well suppressed. In order to damp out these oscillations, usually power system network should have sufficient damping and the increase of network damping is obtained by the injection of subsynchronous component of voltage and current into the line, which are extracted from the measured signal of the system. However, the effectiveness of damp out of these subsynchronous oscillations is possibly by incorporating UPFC in the transmission line network is of high interest and it should be further investigated. This research article proposes the mitigation of subsynchronous resonance (SSR) using fractional-order PI (FOPI) based unified power flow controller (UPFC). The robustness of the proposed controller is tested for 25%, 55% and 70% series compensation with a symmetrical fault (L-L-L fault). Further, Eigenvalue analysis and Fast Fourier Transform (FFT) analysis against operating point variations and uncertainties in the system are also examined. The IEEE first benchmark model is adopted for this study and the superiority of the FOPI based UPFC controller over PI based UPFC controller is discussed by comparing the results with various performance indices.

Evaluation of substrate noise suppression method to mitigate crosstalk among trough-silicon vias

NASA Astrophysics Data System (ADS)

Araga, Yuuki; Kikuchi, Katsuya; Aoyagi, Masahiro

2018-04-01

Substrate noise from a single through-silicon via (TSV) and the noise attenuation by a substrate tap and a guard ring are clarified. A CMOS test vehicle is designed, and 6-µm-diameter TSVs are manufactured on a 20-µm-thick silicon substrate by the via-last method. An on-chip waveform-capturing circuitry is embedded in the test vehicle to capture transient waveforms of substrate noise. The embedded waveform-capturing circuitry demonstrates small and local noise propagation. Experimental results show increased substrate noise level induced by TSVs and the effectiveness of the substrate tap and guard ring for mitigating the crosstalk among TSVs. An analytical model to explain substrate noise propagation is developed to validate experimental results. Results obtained using the substrate model with a multilayer mesh shows good consistency with experimental results, indicating that the model can be used for examination of noise suppression methods.

Jet noise suppression

NASA Astrophysics Data System (ADS)

Gliebe, P. R.; Brausch, J. F.; Majjigi, R. K.; Lee, R.

1991-08-01

The objectives of this chapter are to review and summarize the jet noise suppression technology, to provide a physical and theoretical model to explain the measured jet noise suppression characteristics of different concepts, and to provide a set of guidelines for evolving jet noise suppression designs. The underlying principle for all jet noise suppression devices is to enhance rapid mixing (i.e., diffusion) of the jet plume by geometric and aerothermodynamic means. In the case of supersonic jets, the shock-cell broadband noise reduction is effectively accomplished by the elimination or mitigation of the shock-cell structure. So far, the diffusion concepts have predominantly concentrated on jet momentum and energy (kinetic and thermal) diffusion, in that order, and have yielded better noise reduction than the simple conical nozzles. A critical technology issue that needs resolution is the effect of flight on the noise suppression potential of mechanical suppressor nozzles. A more thorough investigation of this mechanism is necessary for the successful development and design of an acceptable noise suppression device for future high-speed civil transports.

A Computational Investigation of Various Water-Induced Explosion Mitigation Mechanisms

DTIC Science & Technology

2007-01-01

Guidelines for Evaluating the Characteristics of Vapor Cloud Explosions, Flash Fires, and BLEVEs , Center for Chemical Process Safety, AIChE, New York, NY...1994. [6]. Liebman and J. K. Richmond, Suppression of Coal Dust Explosions by Passive Water Barriers in a single Entry Mine , U.S. Bureau of Mines ...R.I. 8294, 1974. [7]. Liebman, J. Corry and J. K. Richmond, Water Barriers for Suppressing Coal Dust Explosions, U.S. Bureau of Mines R.I. 8170

Mitigating amphibian disease: strategies to maintain wild populations and control chytridiomycosis

USGS Publications Warehouse

Woodhams, Douglas C.; Bosch, Jaime; Briggs, Cheryl J.; Cashins, Scott; Davis, Leyla R.; Lauer, Antje; Muths, Erin L.; Puschendorf, Robert; Schmidt, Benedikt R.; Sheafor, Brandon; Voyles, Jamie

2011-01-01

Because sustainable conservation of amphibians in nature is dependent on long-term population persistence and co-evolution with potentially lethal pathogens, we suggest that disease mitigation not focus exclusively on the elimination or containment of the pathogen, or on the captive breeding of amphibian hosts. Rather, successful disease mitigation must be context specific with epidemiologically informed strategies to manage already infected populations by decreasing pathogenicity and host susceptibility. We propose population level treatments based on three steps: first, identify mechanisms of disease suppression; second, parameterize epizootiological models of disease and population dynamics for testing under semi-natural conditions; and third, begin a process of adaptive management in field trials with natural populations.

An examination of changes in maternal neuroimmune function during pregnancy and the postpartum period.

PubMed

Sherer, Morgan L; Posillico, Caitlin K; Schwarz, Jaclyn M

2017-11-01

There is strong evidence that the immune system changes dramatically during pregnancy in order to prevent the developing fetus from being "attacked" by the maternal immune system. Due to these alterations in peripheral immune function, many women that suffer from autoimmune disorders actually find significant relief from their symptoms throughout pregnancy; however, these changes can also leave the mother more susceptible to infections that would otherwise be mitigated by the inflammatory response (Robinson and Klein, 2012). Only one other study has looked at changes in microglial number and morphology during pregnancy and the postpartum period (Haim et al., 2016), but no one has yet examined the neuroimmune response following an immune challenge during this time. Therefore, in this study, we investigated the impact of an immune challenge during various time-points throughout pregnancy and the postpartum period on the expression of immune molecules in the brain of the mother and fetus. Our results indicate that similar to the peripheral immune suppression measured during pregnancy, we also see significant suppression of the immune response in the maternal brain, particularly during late gestation. In contrast to the peripheral immune system, immune modulation in the maternal brain extends moderately into the postpartum period. Additionally, we found that the fetal immune response in the brain and placenta is also suppressed just before parturition, suggesting that cytokine production in the fetus and placenta are mirroring the peripheral cytokine response of the mother. Copyright © 2017 Elsevier Inc. All rights reserved.

Targeting the Renin–Angiotensin System Combined With an Antioxidant Is Highly Effective in Mitigating Radiation-Induced Lung Damage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahmood, Javed; Radiation Medicine Program, STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario; Jelveh, Salomeh

Purpose: To investigate the outcome of suppression of the renin angiotensin system using captopril combined with an antioxidant (Eukarion [EUK]-207) for mitigation of radiation-induced lung damage in rats. Methods and Materials: The thoracic cavity of female Sprague-Dawley rats was irradiated with a single dose of 11 Gy. Treatment with captopril at a dose of 40 mg/kg/d in drinking water and EUK-207 given by subcutaneous injection (8 mg/kg daily) was started 1 week after irradiation (PI) and continuing until 14 weeks PI. Breathing rate was monitored until the rats were killed at 32 weeks PI, when lung fibrosis was assessed by lung hydroxyproline content. Lung levels ofmore » the cytokine transforming growth factor-β1 and macrophage activation were analyzed by immunohistochemistry. Oxidative DNA damage was assessed by 8-hydroxy-2-deoxyguanosine levels, and lipid peroxidation was measured by a T-BARS assay. Results: The increase in breathing rate in the irradiated rats was significantly reduced by the drug treatments. The drug treatment also significantly decreased the hydroxyproline content, 8-hydroxy-2-deoxyguanosine and malondialdehyde levels, and levels of activated macrophages and the cytokine transforming growth factor-β1 at 32 weeks. Almost complete mitigation of these radiation effects was observed by combining captopril and EUK-207. Conclusion: Captopril and EUK-207 can provide mitigation of radiation-induced lung damage out to at least 32 weeks PI after treatment given 1-14 weeks PI. Overall the combination of captopril and EUK-207 was more effective than the individual drugs used alone.« less

CHARIS Construction Status, Design, and Future Science

NASA Astrophysics Data System (ADS)

Groff, Tyler Dean; Kasdin, N. Jeremy; Peters, Mary Anne; Galvin, Michael; Knapp, Gillian R.; Brandt, Timothy; Loomis, Craig; Carr, Michael; Mede, Kyle; Jarosik, Norman; McElwain, Michael W.; Guyon, Olivier; Jovanovic, Nemanja; Takato, Naruhisa; Hayashi, Masahiko

2015-01-01

Princeton University is funded by the National Astronomical Observatory of Japan to build an integral field spectrograph (IFS) dubbed the Coronagraphic High Angular Resolution Imaging Spectrograph (CHARIS). CHARIS is part of the ongoing exoplanet science effort at the Subaru Telescope, and will serve as the science imager for the Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) and AO188 systems. The principal science goals are disk imaging and high contrast spectra of brown dwarfs and hot Jovian planets across J, H, and K bands. SCExAO is a coronagraphic and wavefront control system that will be capable of extreme adaptive optics and quasi-static speckle suppression. Speckle suppression is meant to reduce the residual speckle to a level that makes it possible to detect planets at very low inner working angles (~80 mas). Even so, CHARIS must mitigate spectral contamination from the residual speckle halo due to crosstalk between the closely packed spectra of the image. CHARIS mitigates crosstalk via an array of field stops behind the lenslet array and carefully toleranced relay optics. This reduces uncertainty in the measured spectrum of the exoplanets by increasing robustness of the spectrograph to nearby bright speckles. Mitigating crosstalk in hardware both improves science and reduces computational overhead. Combined with a detailed wavefront budget this improves the utility of CHARIS in the speckle control loop. Another defining feature of CHARIS is its disperser design. In addition to imaging in individual J, H, and K bands, CHARIS has a fourth mode that images across all three simultaneously. This required an improvement in the linearity of dispersion from 1.15 to 2.38 microns. To do so the CHARIS project has chosen a new high-index dispersing material and characterized its properties at cryogenic temperatures. We present the build status of the spectrograph, including status and viability of operating an H2RG detector directly using a SAM card via gigabit Ethernet over Linux. In addition to the stated and as-built specifications of the instrument hardware, we discuss the future of science impacts of CHARIS at the Subaru telescope.

Analysis and control of the dynamical response of a higher order drifting oscillator

PubMed Central

Páez Chávez, Joseph; Pavlovskaia, Ekaterina; Wiercigroch, Marian

2018-01-01

This paper studies a position feedback control strategy for controlling a higher order drifting oscillator which could be used in modelling vibro-impact drilling. Special attention is given to two control issues, eliminating bistability and suppressing chaos, which may cause inefficient and unstable drilling. Numerical continuation methods implemented via the continuation platform COCO are adopted to investigate the dynamical response of the system. Our analyses show that the proposed controller is capable of eliminating coexisting attractors and mitigating chaotic behaviour of the system, providing that its feedback control gain is chosen properly. Our investigations also reveal that, when the slider’s property modelling the drilled formation changes, the rate of penetration for the controlled drilling can be significantly improved. PMID:29507508

Analysis and control of the dynamical response of a higher order drifting oscillator

NASA Astrophysics Data System (ADS)

Liu, Yang; Páez Chávez, Joseph; Pavlovskaia, Ekaterina; Wiercigroch, Marian

2018-02-01

This paper studies a position feedback control strategy for controlling a higher order drifting oscillator which could be used in modelling vibro-impact drilling. Special attention is given to two control issues, eliminating bistability and suppressing chaos, which may cause inefficient and unstable drilling. Numerical continuation methods implemented via the continuation platform COCO are adopted to investigate the dynamical response of the system. Our analyses show that the proposed controller is capable of eliminating coexisting attractors and mitigating chaotic behaviour of the system, providing that its feedback control gain is chosen properly. Our investigations also reveal that, when the slider's property modelling the drilled formation changes, the rate of penetration for the controlled drilling can be significantly improved.

Suppression of Rayleigh backscattering noise using cascaded-SOA and microwave photonic filter for 10 Gb/s loop-back WDM-PON.

PubMed

Feng, Hanlin; Ge, Jia; Xiao, Shilin; Fok, Mable P

2014-05-19

In this paper, we present a novel Rayleigh backscattering (RB) noise mitigation scheme based on central carrier suppression for 10 Gb/s loop-back wavelength division multiplexing passive optical network (WDM-PON). Microwave modulated multi-subcarrier optical signal is used as downstream seeding light, while cascaded semiconductor optical amplifier (SOA) are used in the optical network unit (ONU) for suppressing the central carrier of the multi-subcarrier upstream signal. With central carrier suppression, interference generated by carrier RB noise at low frequency region is eliminated successfully. Transmission performance over 45 km single mode fiber (SMF) is studied experimentally, and the optical-signal-to-Rayleigh-noise-ratio (OSRNR) can be reduced to 15 dB with central carrier suppression ratio (CCSR) of 21 dB. Receiver sensitivity is further improved by 6 dB with the use of microwave photonic filter (MPF) for suppressing residual upstream microwave signal and residual carrier RB at high frequency region.

Regulatory T cells and the immune pathogenesis of prenatal infection

PubMed Central

Rowe, Jared H.; Ertelt, James M.; Xin, Lijun; Way, Sing Sing

2013-01-01

Pregnancy in placental mammals offers exceptional comprehensive benefits of in utero protection, nutrition, and elimination of metabolic waste for the developing fetus. However, these advantages also require durable strategies to mitigate maternal rejection of fetal tissue expressing foreign paternal antigens. Since the initial postulate of expanded maternal immune tolerance by Sir Peter Medawar 60 years ago, an amazingly elaborate assortment of molecular and cellular modifications acting both locally at the maternal placental interface and systemically have been shown to silence potentially detrimental maternal immune responses. In turn, simultaneously maintaining host defense against the infinite array of potential pathogens during pregnancy is equally important. Fortunately, resistance against most infections is preserved seamlessly throughout gestation. On the other hand, recent studies on pathogens with unique predisposition for prenatal infection have uncovered distinctive holes in host defense associated with the reproductive process. Using these infections to probe the response during pregnancy, the immune suppressive regulatory subset of maternal CD4 T cells has been increasingly shown to dictate the inter-workings between prenatal infection susceptibility and pathogenesis of ensuing pregnancy complications. Herein, the recent literature suggesting a necessity for maternal regulatory T cells in pregnancy induced immunological shifts that sustain fetal tolerance is reviewed. Additional discussion is focused on how expansion of maternal regulatory T cell suppression may become exploited by pathogens that cause prenatal infection, and the perilous potential of infection induced immune activation that may mitigate fetal tolerance and inadvertently inject hostility into the protective in utero environment. PMID:23929902

Vortex-induced vibrations mitigation through a nonlinear energy sink

NASA Astrophysics Data System (ADS)

Dai, H. L.; Abdelkefi, A.; Wang, L.

2017-01-01

The passive suppression mechanism of the vortex-induced vibrations (VIV) of the cylinder by means of an essentially nonlinear element, the nonlinear energy sink (NES) is investigated. The flow-induced loads on the cylinder are modeled using a prevalent van der Pol oscillator which is experimentally validated, coupling to the structural vibrations in the presence of the NES structure. Based on the coupled nonlinear governing equations of motion, the performed analysis indicates that the mass and damping of NES have significant effects on the coupled frequency and damping of the aero-elastic system, leading to the shift of synchronization region and mitigation of vibration responses. It is demonstrated that the coupled system of flow-cylinder-NES behaves resonant interactions, showing periodic, aperiodic, and multiple stable responses which depend on the values of the NES parameters. In addition, it is found that the occurrence of multiple stable responses can enhance the nonlinear energy pumping effect, resulting in the increment of transferring energy from the flow via the cylinder to the NES, which is related to the essential nonlinearity of the sink stiffness. This results in a significant reduction in the VIV amplitudes of the primary circular cylinder for appropriate NES parameter values.

Apodized RFI filtering of synthetic aperture radar images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doerry, Armin Walter

2014-02-01

Fine resolution Synthetic Aperture Radar (SAR) systems necessarily require wide bandwidths that often overlap spectrum utilized by other wireless services. These other emitters pose a source of Radio Frequency Interference (RFI) to the SAR echo signals that degrades SAR image quality. Filtering, or excising, the offending spectral contaminants will mitigate the interference, but at a cost of often degrading the SAR image in other ways, notably by raising offensive sidelobe levels. This report proposes borrowing an idea from nonlinear sidelobe apodization techniques to suppress interference without the attendant increase in sidelobe levels. The simple post-processing technique is termed Apodized RFImore » Filtering (ARF).« less

The suppression of ghrelin signaling mitigates age-associated thermogenic impairment

USDA-ARS?s Scientific Manuscript database

Aging is associated with severe thermogenic impairment, which contributes to obesity and diabetes in aging. We previously reported that ablation of the ghrelin receptor, growth hormone secretagogue receptor (GHS-R), attenuates age-associated obesity and insulin resistance. Ghrelin and obestatin are ...

Availability: A Metric for Nucleic Acid Strand Displacement Systems.

PubMed

Olson, Xiaoping; Kotani, Shohei; Padilla, Jennifer E; Hallstrom, Natalya; Goltry, Sara; Lee, Jeunghoon; Yurke, Bernard; Hughes, William L; Graugnard, Elton

2017-01-20

DNA strand displacement systems have transformative potential in synthetic biology. While powerful examples have been reported in DNA nanotechnology, such systems are plagued by leakage, which limits network stability, sensitivity, and scalability. An approach to mitigate leakage in DNA nanotechnology, which is applicable to synthetic biology, is to introduce mismatches to complementary fuel sequences at key locations. However, this method overlooks nuances in the secondary structure of the fuel and substrate that impact the leakage reaction kinetics in strand displacement systems. In an effort to quantify the impact of secondary structure on leakage, we introduce the concepts of availability and mutual availability and demonstrate their utility for network analysis. Our approach exposes vulnerable locations on the substrate and quantifies the secondary structure of fuel strands. Using these concepts, a 4-fold reduction in leakage has been achieved. The result is a rational design process that efficiently suppresses leakage and provides new insight into dynamic nucleic acid networks.

Method and apparatus for suppressing regenerative instability and related chatter in machine tools

DOEpatents

Segalman, Daniel J.; Redmond, James M.

2001-01-01

Methods of and apparatuses for mitigating chatter vibrations in machine tools or components thereof. Chatter therein is suppressed by periodically or continuously varying the stiffness of the cutting tool (or some component of the cutting tool), and hence the resonant frequency of the cutting tool (or some component thereof). The varying of resonant frequency of the cutting tool can be accomplished by modulating the stiffness of the cutting tool, the cutting tool holder, or any other component of the support for the cutting tool. By periodically altering the impedance of the cutting tool assembly, chatter is mitigated. In one embodiment, a cyclic electric (or magnetic) field is applied to the spindle quill which contains an electro-rheological (or magneto-rheological) fluid. The variable yield stress in the fluid affects the coupling of the spindle to the machine tool structure, changing the natural frequency of oscillation. Altering the modal characteristics in this fashion disrupts the modulation of current tool vibrations with previous tool vibrations recorded on the workpiece surface.

Method and apparatus for suppressing regenerative instability and related chatter in machine tools

DOEpatents

Segalman, Daniel J.; Redmond, James M.

1999-01-01

Methods of and apparatuses for mitigating chatter vibrations in machine tools or components thereof. Chatter therein is suppressed by periodically or continuously varying the stiffness of the cutting tool (or some component of the cutting tool), and hence the resonant frequency of the cutting tool (or some component thereof). The varying of resonant frequency of the cutting tool can be accomplished by modulating the stiffness of the cutting tool, the cutting tool holder, or any other component of the support for the cutting tool. By periodically altering the impedance of the cutting tool assembly, chatter is mitigated. In one embodiment, a cyclic electric (or magnetic) field is applied to the spindle quill which contains an electro-rheological (or magneto-rheological) fluid. The variable yield stress in the fluid affects the coupling of the spindle to the machine tool structure, changing the natural frequency of oscillation. Altering the modal characteristics in this fashion disrupts the modulation of current tool vibrations with previous tool vibrations recorded on the workpiece surface.

Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: Modulation of oxidative stress and inflammatory mediators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arab, Hany H., E-mail: hany_h_arab@yahoo.com; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo; El-Sawalhi, Maha M.

Rheumatoid arthritis (RA) is a systemic inflammatory disease with cardiovascular complications as the leading cause of morbidity. Carvedilol is an adrenergic antagonist which has been safely used in treatment of several cardiovascular disorders. Given that carvedilol has powerful antioxidant/anti-inflammatory properties, we aimed to investigate its protective potential against arthritis that may add further benefits for its clinical usefulness especially in RA patients with concomitant cardiovascular disorders. Two models were studied in the same rat; adjuvant arthritis and subcutaneous air pouch edema. Carvedilol (10 mg/kg/day p.o. for 21 days) effectively suppressed inflammation in both models with comparable efficacy to the standardmore » anti-inflammatory diclofenac (5 mg/kg/day p.o.). Notably, carvedilol inhibited paw edema and abrogated the leukocyte invasion to air pouch exudates. The latter observation was confirmed by the histopathological assessment of the pouch lining that revealed mitigation of immuno-inflammatory cell influx. Carvedilol reduced/normalized oxidative stress markers (lipid peroxides, nitric oxide and protein thiols) and lowered the release of inflammatory cytokines (TNF-α and IL-6), and eicosanoids (PGE{sub 2} and LTB{sub 4}) in sera and exudates of arthritic rats. Interestingly, carvedilol, per se, didn't present any effect on assessed biochemical parameters in normal rats. Together, the current study highlights evidences for the promising anti-arthritic effects of carvedilol that could be mediated through attenuation of leukocyte migration, alleviation of oxidative stress and suppression of proinflammatory cytokines and eicosanoids. - Highlights: ► Carvedilol possesses promising anti-arthritic properties. ► It markedly suppressed inflammation in adjuvant arthritis and air pouch edema. ► It abrogated the leukocyte invasion to air pouch exudates and linings. ► It reduced/normalized oxidative stress markers in sera and exudates of arthritic rats. ► It also mitigated the release of proinflammatory cytokines and eicosanoids.« less

Androgen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells

PubMed Central

Lai, Hsueh-Chou; Yeh, Chun-Chieh; Jeng, Long-Bin; Huang, Shang-Fen; Liao, Pei-Ying; Lei, Fu-Ju; Cheng, Wei-Chun; Hsu, Cheng-Lung; Cai, Xiujun; Chang, Chawnshang; Ma, Wen-Lung

2016-01-01

Purpose Although hepatectomy and liver transplantation surgery for hepatocellular carcinoma (HCC) are effective treatment modalities, the risk of recurrence remains high, particularly in patients with a high number of circulating tumor cells (CTCs) expressing cancer stem/progenitor cell markers. Androgen receptor (AR) signaling has been shown to suppress HCC metastasis in rodent models of HCC. In this study, we investigated whether AR is associated with postoperative HCC recurrence. Experimental Design CTCs were obtained from patients with HCC who had undergone hepatectomy to investigate whether they are associated with disease outcome. AR knockout was introduced in two mouse models of spontaneous HCC (carcinogen- and hepatitis B virus-related HCC) to delineate the role that AR plays in HCC recurrence. Biological systems analysis was used to investigate the cellular and molecular mechanisms. Results We found that the expression of AR in CTCs was negatively associated with HCC recurrence/progression after hepatectomy. Our results suggest that AR-mediated suppression of HCC recurrence/progression is governed by a three-pronged mechanism. First, AR suppresses the expression of CD90 in CTCs by upregulating Histone 3H2A. Second, AR suppresses cell migration at the transcriptome level. Third, AR promotes anoikis of CTCs via dysregulation of cytoskeletal adsorption. Conclusions The results indicate that AR expression may be the gatekeeper of postoperative HCC recurrence. Therefore, targeting AR in presurgical down-staging procedures may serve as a secondary prevention measure against HCC recurrence in the future. PMID:27340775

Suppression of emission rates improves sonar performance by flying bats.

PubMed

Adams, Amanda M; Davis, Kaylee; Smotherman, Michael

2017-01-31

Echolocating bats face the challenge of actively sensing their environment through their own emissions, while also hearing calls and echoes of nearby conspecifics. How bats mitigate interference is a long-standing question that has both ecological and technological implications, as biosonar systems continue to outperform man-made sonar systems in noisy, cluttered environments. We recently showed that perched bats decreased calling rates in groups, displaying a behavioral strategy resembling the back-off algorithms used in artificial communication networks to optimize information throughput at the group level. We tested whether free-tailed bats (Tadarida brasiliensis) would employ such a coordinated strategy while performing challenging flight maneuvers, and report here that bats navigating obstacles lowered emission rates when hearing artificial playback of another bat's calls. We measured the impact of acoustic interference on navigation performance and show that the calculated reductions in interference rates are sufficient to reduce interference and improve obstacle avoidance. When bats flew in pairs, each bat responded to the presence of the other as an obstacle by increasing emissions, but hearing the sonar emissions of the nearby bat partially suppressed this response. This behavior supports social cohesion by providing a key mechanism for minimizing mutual interference.

Frequency-tunable Pre-stabilized Lasers for LISA via Sideband-locking

NASA Technical Reports Server (NTRS)

Livas, Jeffrey C.; Thorpe, James I.; Numata, Kenji; Mitryk, Shawn; Mueller, Guido; Wand, Vinzenz

2008-01-01

Laser frequency noise mitigation is one of the most challenging aspects of the LISA interferometric measurement system. The unstabilized frequency fluctuations must be suppressed by roughly twelve orders of magnitude in order to achieve stability sufficient for gravitational wave detection. This enormous suppression will be achieved through a combination of stabilization and common-mode rejection. The stabilization component will itself be achieved in two stages: pre-stabilization to a local optical cavity followed by arm-locking to some combination of the inter-spacecraft distances. In order for these two stabilization stages to work simultaneously, the lock-point of the pre-stabilization loop must be frequency tunable. The current baseline stabilization technique, locking to an optical cavity, does not provide tunability between cavity resonances, which are typically spaced by 100s of MHz. Here we present a modification to the traditional Pound-Drever-Hall cavity locking technique that allows the laser to be locked to a cavity resonance with an adjustable frequency offset. This technique requires no modifications to the optical cavity itself, thus preserving the stability of the frequency reference. We present measurements of the system performance and demonstrate that we can meet implement the first two stages of stabilization.

Suppression of emission rates improves sonar performance by flying bats

PubMed Central

Adams, Amanda M.; Davis, Kaylee; Smotherman, Michael

2017-01-01

Echolocating bats face the challenge of actively sensing their environment through their own emissions, while also hearing calls and echoes of nearby conspecifics. How bats mitigate interference is a long-standing question that has both ecological and technological implications, as biosonar systems continue to outperform man-made sonar systems in noisy, cluttered environments. We recently showed that perched bats decreased calling rates in groups, displaying a behavioral strategy resembling the back-off algorithms used in artificial communication networks to optimize information throughput at the group level. We tested whether free-tailed bats (Tadarida brasiliensis) would employ such a coordinated strategy while performing challenging flight maneuvers, and report here that bats navigating obstacles lowered emission rates when hearing artificial playback of another bat’s calls. We measured the impact of acoustic interference on navigation performance and show that the calculated reductions in interference rates are sufficient to reduce interference and improve obstacle avoidance. When bats flew in pairs, each bat responded to the presence of the other as an obstacle by increasing emissions, but hearing the sonar emissions of the nearby bat partially suppressed this response. This behavior supports social cohesion by providing a key mechanism for minimizing mutual interference. PMID:28139707

Evaluation of NDI compressed air foam system (cafs) applied as a retrofit. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, S.

1994-08-01

Army Engineer Firefighting Detachments require increased firefighting capability to compensate for deficiencies in structural, brush, or wildland and large petroleum storage site fires. Additionally, Army fire departments responsible for protection and prevention on posts, camps and stations have difficulty accessing new or emerging technology do not possess state-of-the-art equipment. The results of this evaluation and subsequent projects, will be reported throughout the Army in an attempt to mitigate operational deficiencies and widen the scope of knowledge in the Army fire service. The evaluation of non-developmental retrofitted compressed air foam systems show an efficiency of suppressive capabilities of water superseded bymore » water alone. Retrofitting the equipment was not easy or inexpensive but it was very successful.« less

ELM suppression in helium plasmas with 3D magnetic fields

DOE PAGES

Evans, T. E.; Loarte, A.; Orlov, D. M.; ...

2017-06-21

Experiments in DIII-D, using non-axisymmetric magnetic perturbation fields in high-purity low toroidal rotation, 4He plasmas have resulted in Type-I edge localized mode (ELM) suppression and mitigation. Suppression is obtained in plasmas with zero net input torque near the L–H power threshold using either electron cyclotron resonant heating (ECRH) or balanced co- and counter-I p neutral beam injection (NBI) resulting in conditions equivalent to those expected in ITER's non-active operating phase. In low-power ECRH H-modes, periods with uncontrolled density and impurity radiation excursions are prevented by applying n = 3 non-axisymmetric magnetic perturbation fields. ELM suppression results from a reduction andmore » an outward shift of the electron pressure gradient peak compared to that in the high-power ELMing phase. Here, the change in the electron pressure gradient peak is primarily due to a drop in the pedestal temperature rather than the pedestal density.« less

ELM suppression in helium plasmas with 3D magnetic fields

NASA Astrophysics Data System (ADS)

Evans, T. E.; Loarte, A.; Orlov, D. M.; Grierson, B. A.; Knölker, M. M.; Lyons, B. C.; Cui, L.; Gohil, P.; Groebner, R. J.; Moyer, R. A.; Nazikian, R.; Osborne, T. H.; Unterberg, E. A.

2017-08-01

Experiments in DIII-D, using non-axisymmetric magnetic perturbation fields in high-purity low toroidal rotation, 4He plasmas have resulted in Type-I edge localized mode (ELM) suppression and mitigation. Suppression is obtained in plasmas with zero net input torque near the L-H power threshold using either electron cyclotron resonant heating (ECRH) or balanced co- and counter-I p neutral beam injection (NBI) resulting in conditions equivalent to those expected in ITER’s non-active operating phase. In low-power ECRH H-modes, periods with uncontrolled density and impurity radiation excursions are prevented by applying n  =  3 non-axisymmetric magnetic perturbation fields. ELM suppression results from a reduction and an outward shift of the electron pressure gradient peak compared to that in the high-power ELMing phase. The change in the electron pressure gradient peak is primarily due to a drop in the pedestal temperature rather than the pedestal density.

Enhancement of runaway production by resonant magnetic perturbation on J-TEXT

NASA Astrophysics Data System (ADS)

Chen, Z. Y.; Huang, D. W.; Izzo, V. A.; Tong, R. H.; Jiang, Z. H.; Hu, Q. M.; Wei, Y. N.; Yan, W.; Rao, B.; Wang, S. Y.; Ma, T. K.; Li, S. C.; Yang, Z. J.; Ding, D. H.; Wang, Z. J.; Zhang, M.; Zhuang, G.; Pan, Y.; J-TEXT Team

2016-07-01

The suppression of runaways following disruptions is key for the safe operation of ITER. The massive gas injection (MGI) has been developed to mitigate heat loads, electromagnetic forces and runaway electrons (REs) during disruptions. However, MGI may not completely prevent the generation of REs during disruptions on ITER. Resonant magnetic perturbation (RMP) has been applied to suppress runaway generation during disruptions on several machines. It was found that strong RMP results in the enhancement of runaway production instead of runaway suppression on J-TEXT. The runaway current was about 50% pre-disruption plasma current in argon induced reference disruptions. With moderate RMP, the runway current decreased to below 30% pre-disruption plasma current. The runaway current plateaus reach 80% of the pre-disruptive current when strong RMP was applied. Strong RMP may induce large size magnetic islands that could confine more runaway seed during disruptions. This has important implications for runaway suppression on large machines.

Rye cover crop effects on soil properties in no-till corn silage/soybean agroecosystems

USDA-ARS?s Scientific Manuscript database

Farmers in the U.S. Corn Belt are showing increasing interest in winter cover crops. Known benefits of winter cover crops include reductions in nutrient leaching, erosion mitigation, and weed suppression, however little research has investigated the effects of winter cover crops on soil properties. ...

Suppression of GHS-R in AgRP neurons mitigates diet-induced obesity by activating thermogenesis

USDA-ARS?s Scientific Manuscript database

Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in...

Reducing social losses from forest fires

Treesearch

Gregory S. Amacher; Arun S. Malik; Robert G. Haight

2006-01-01

We evaluate two financial incentives to encourage nonindustrial forest landowners to undertake activities that mitigate fire losses: sharing of fire suppression costs by the landowner and sharing of fuel reduction costs by the government. First and second best outcomes are identified and compared to assess the effectiveness of these incentives in reducing social...

Transient synchronization following invasion: revisiting Moran's model and a case study

Treesearch

Ottar N. Bjørnstad; Andrew M. Liebhold; Derek M. Johnson

2008-01-01

Synchrony in forest insect outbreaks is important because the resulting regionalized outbreak dilutes the regulating effects of natural enemies, reduces the landscape's ability to buffer the disturbance, exacerbates the economic burden on individual stakeholders, and overwhelms the logistical abilities of managers to suppress populations and mitigate impacts....

Results and Insights on the Impact of Smoke on Digital Instrumentation and Control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tanaka, T. J.; Nowlen, S. P.

2001-01-31

Smoke can cause interruptions and upsets in active electronics. Because nuclear power plants are replacing analog with digital instrumentation and control systems, qualification guidelines for new systems are being reviewed for severe environments such as smoke and electromagnetic interference. Active digital systems, individual components, and active circuits have been exposed to smoke in a program sponsored by the U.S. Nuclear Regulatory Commission. The circuits and systems were all monitored during the smoke exposure, indicating any immediate effects of the smoke. The major effect of smoke has been to increase leakage currents (through circuit bridging across contacts and leads) and tomore » cause momentary upsets and failures in digital systems. This report summarizes two previous reports and presents new results from conformal coating, memory chip, and hard drive tests. The report describes practices for mitigation of smoke damage through digital system design, fire barriers, ventilation, fire suppressants, and post fire procedures.« less

Characterization of the Ignition Over-Pressure/Sound Suppression Water in the Space Launch System Mobile Launcher Using Volume of Fluid Modeling

NASA Technical Reports Server (NTRS)

West, Jeff

2015-01-01

The Space Launch System (SLS) Vehicle consists of a Core Stage with four RS-25 engines and two Solid Rocket Boosters (SRBs). This vehicle is launched from the Launchpad using a Mobile Launcher (ML) which supports the SLS vehicle until its liftoff from the ML under its own power. The combination of the four RS-25 engines and two SRBs generate a significant Ignition Over-Pressure (IOP) and Acoustic Sound environment. One of the mitigations of these environments is the Ignition Over-Pressure/Sound Suppression (IOP/SS) subsystem installed on the ML. This system consists of six water nozzles located parallel to and 24 inches downstream of each SRB nozzle exit plane as well as 16 water nozzles located parallel to and 53 inches downstream of the RS-25 nozzle exit plane. During launch of the SLS vehicle, water is ejected through each water nozzle to reduce the intensity of the transient pressure environment imposed upon the SLS vehicle. While required for the mitigation of the transient pressure environment on the SLS vehicle, the IOP/SS subsystem interacts (possibly adversely) with other systems located on the Launch Pad. One of the other systems that the IOP/SS water is anticipated to interact with is the Hydrogen Burn-Off Igniter System (HBOI). The HBOI system's purpose is to ignite the unburned hydrogen/air mixture that develops in and around the nozzle of the RS-25 engines during engine start. Due to the close proximity of the water system to the HBOI system, the presence of the IOP/SS may degrade the effectiveness of the HBOI system. Another system that the IOP/SS water may interact with adversely is the RS-25 engine nozzles and the SRB nozzles. The adverse interaction anticipated is the wetting, to a significant degree, of the RS-25 nozzles resulting in substantial weight of ice forming and water present to a significant degree upstream of the SRB nozzle exit plane inside the nozzle itself, posing significant additional blockage of the effluent that exits the nozzle upon motor start leading to detrimental effects. The purpose of the CFD simulations were to i) characterize the location of the IOP/SS water after it is ejected from the IOP/SS nozzles, ii) characterize the interaction of the IOP/SS system with the HBOI system and iii) characterize the interaction of the IOP/SS water with the RS-25 nozzles and the SRB nozzles.

Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance.

PubMed

Arai, Chikako; Arai, Norie; Mizote, Akiko; Kohno, Keizo; Iwaki, Kanso; Hanaya, Toshiharu; Arai, Shigeyuki; Ushio, Simpei; Fukuda, Shigeharu

2010-12-01

Trehalose has been shown to evoke lower insulin secretion than glucose in oral saccharide tolerance tests in humans. Given this hypoinsulinemic effect of trehalose, we hypothesized that trehalose suppresses adipocyte hypertrophy by reducing storage of triglyceride and mitigates insulin resistance in mice fed a high-fat diet (HFD). Mice were fed an HFD and given drinking water containing 2.5% saccharide (glucose [Glc], trehalose [Tre], maltose [Mal], high-fructose corn syrup, or fructose [Fru]) ad libitum. After 7 weeks of HFD and saccharide intake, fasting serum insulin levels in the Tre/HFD group were significantly lower than in the Mal/HFD and Glc/HFD groups (P < .05). Furthermore, the Tre/HFD group showed a significantly suppressed elevation of homeostasis model assessment-insulin resistance compared with the Mal/HFD group (P < .05) and showed a trend toward lower homeostasis model assessment-insulin resistance than the Glc/HFD group. After 8 weeks of feeding, mesenteric adipocyte size in the Tre/HFD group showed significantly less hypertrophy than the Glc/HFD, Mal/HFD, high-fructose corn syrup/HFD, or Fru/HFD group. Analysis of gene expression in mesenteric adipocytes showed that no statistically significant difference in the expression of monocyte chemoattractant protein-1 (MCP-1) messenger RNA (mRNA) was observed between the Tre/HFD group and the distilled water/standard diet group, whereas a significant increase in the MCP-1 mRNA expression was observed in the Glc/HFD, Mal/HFD, Fru/HFD, and distilled water/HFD groups. Thus, our data indicate that trehalose prevents adipocyte hypertrophy and mitigates insulin resistance in HFD-fed mice by reducing insulin secretion and down-regulating mRNA expression of MCP-1. These findings further suggest that trehalose is a functional saccharide that mitigates insulin resistance. Copyright © 2010 Elsevier Inc. All rights reserved.

Phase noise mitigation of QPSK signal utilizing phase-locked multiplexing of signal harmonics and amplitude saturation.

PubMed

Mohajerin-Ariaei, Amirhossein; Ziyadi, Morteza; Chitgarha, Mohammad Reza; Almaiman, Ahmed; Cao, Yinwen; Shamee, Bishara; Yang, Jeng-Yuan; Akasaka, Youichi; Sekiya, Motoyoshi; Takasaka, Shigehiro; Sugizaki, Ryuichi; Touch, Joseph D; Tur, Moshe; Langrock, Carsten; Fejer, Martin M; Willner, Alan E

2015-07-15

We demonstrate an all-optical phase noise mitigation scheme based on the generation, delay, and coherent summation of higher order signal harmonics. The signal, its third-order harmonic, and their corresponding delayed variant conjugates create a staircase phase-transfer function that quantizes the phase of quadrature-phase-shift-keying (QPSK) signal to mitigate phase noise. The signal and the harmonics are automatically phase-locked multiplexed, avoiding the need for phase-based feedback loop and injection locking to maintain coherency. The residual phase noise converts to amplitude noise in the quantizer stage, which is suppressed by parametric amplification in the saturation regime. Phase noise reduction of ∼40% and OSNR-gain of ∼3  dB at BER 10(-3) are experimentally demonstrated for 20- and 30-Gbaud QPSK input signals.

Robust output feedback stabilization for a flexible marine riser system.

PubMed

Zhao, Zhijia; Liu, Yu; Guo, Fang

2017-12-06

The aim of this paper is to develop a boundary control for the vibration reduction of a flexible marine riser system in the presence of parametric uncertainties and system states obtained inaccurately. To this end, an adaptive output feedback boundary control is proposed to suppress the riser's vibration fusing with observer-based backstepping, high-gain observers and robust adaptive control theory. In addition, the parameter adaptive laws are designed to compensate for the system parametric uncertainties, and the disturbance observer is introduced to mitigate the effects of external environmental disturbance. The uniformly bounded stability of the closed-loop system is achieved through rigorous Lyapunov analysis without any discretisation or simplification of the dynamics in the time and space, and the state observer error is ensured to exponentially converge to zero as time grows to infinity. In the end, the simulation and comparison studies are carried out to illustrate the performance of the proposed control under the proper choice of the design parameters. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Mitigation of Disasters Due to Severe Climate Events: from Policy to Practice,the West African Coastal Region Experience

NASA Astrophysics Data System (ADS)

Ediang, Okuku

2016-07-01

The distributive pattern of disaster due to severe climate events over the coast of West Africa especially Nigeria was examined using yearly mean disaster due to severe climatic events for the period of 30 years (1981-2010) from the marine stations in the coastal region of Nigeria. Graphical and isohyetal analyses were used to look into the patter of severe weather events over the area considered and to see if the severe weather events is increasing or not in the coast of West Africa especially the Nigerian coast and how to mitigate ,were policy relating to severe weather events are discussed. The paper conclude that due to the nature of coast of West Africa and Nigeria in particular, it enjoys longer severe weather events season than dry during the wet season, it is common to observe periods of enhanced or suppressed convective activity to persist over the wide areas for somedays. This paper also contributes to the wealth of knowledge already existing on Indigenous people play major roles in preserving the ecosystem especially during severe weather events . This has resulted in the recent calls for the integration of indigenous knowledge systems into global knowledge system strategies. Until now, integrating local knowledge systems into severe weather events and climate change concerns is not a completely new idea. A comprehensive review of literature using electronic and non-electronic databases formed the methodology. The paper conclude also by drawing the attention that by targeting Promoting indigenous people's participation in severe weather events and climate change issues is an important initiative towards adaptation and sustainable development in Africa and around the world. It is increasingly realized that the global knowledge system has dominated research, policies and programmes that address current severe weather events and climate change's challenges,mitigation and adaptation strategies.

Learning to coexist with wildfire

Treesearch

M.A. Moritz; E. Batlloria; R.A. Bradstock; Jeff Stringer; Robbie Sitzlar; P.F. Hessburg; J. Leonard; S. McCaffrey; D.C. Odion; T. Schoennagel; A.D. Syphard

2014-01-01

The impacts of escalating wildfire in many regions — the lives and homes lost, the expense of suppression and the damage to ecosystem services — necessitate a more sustainable coexistence with wildfire. Climate change and continued development on fire-prone landscapes will only compound current problems. Emerging strategies for managing ecosystems and mitigating risks...

Understanding the side effects of classical biological control

Treesearch

Dean Pearson

2008-01-01

Classical biological control involves the use of imported natural enemies to suppress or control populations of the target pest species below an economically or ecologically relevant threshold. Biological control is a useful tool for mitigating the impacts of exotic invasive plants; however, its application is not without risk (see Carruthers and D’Antonio...

75 FR 67784 - STP Nuclear Operating Company South Texas Project Electric Generating Station, Units 3 and 4...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-03

.... Mitigation measures, such as operational controls and practices, worker training, use of personal protective... equipment emissions, and fugitive dust caused by earth-moving activities. As stated in the ER for the COL... fugitive dust and vehicle and equipment emissions, including water suppression, covering truck loads and...

The once and future forest: Consequences of mountain pine beetle treatment decisions

Treesearch

Nancy E. Gillette; David L. Wood; Sarah J. Hines; Justin B. Runyon; Jose F. Negron

2014-01-01

Entomologists and silviculturists have long recommended management of stand basal area and/or mean tree diameter to mitigate the risk of mountain pine beetle (MPB) (Dendroctonus ponderosae Hopkins) outbreaks while simultaneously reducing wildfire risk. In recent decades, however, wildfire suppression and reduced harvests in western North America have created a forest...

Carbon Monoxide: An Essential Signalling Molecule

NASA Astrophysics Data System (ADS)

Mann, Brian E.

Carbon monoxide (CO), like nitric oxide (NO), is an essential signalling molecule in humans. It is active in the cardiovascular system as a vasodilator. In addition, CO possesses anti-inflammatory, anti-apoptotic and anti-proliferative properties and protects tissues from hypoxia and reperfusion injury. Some of its applications in animal models include suppression of organ graft rejection and safeguarding the heart during reperfusion after cardiopulmonary bypass surgery. CO also suppresses arteriosclerotic lesions following angioplasty, reverses established pulmonary hypertension and mitigates the development of post-operative ileus in the murine small intestine and the development of cerebral malaria in mice as well as graft-induced intimal hyperplasia in pigs. There have been several clinical trials using air-CO mixtures for the treatment of lung-, heart-, kidney- and abdominal-related diseases. This review examines the research involving the development of classes of compounds (with particular emphasis on metal carbonyls) that release CO, which could be used in clinically relevant conditions. The review is drawn not only from published papers in the chemical literature but also from the extensive biological literature and patents on CO-releasing molecules (CO-RMs).

Active chatter suppression with displacement-only measurement in turning process

NASA Astrophysics Data System (ADS)

Ma, Haifeng; Wu, Jianhua; Yang, Liuqing; Xiong, Zhenhua

2017-08-01

Regenerative chatter is a major hindrance for achieving high quality and high production rate in machining processes. Various active controllers have been proposed to mitigate chatter. However, most of existing controllers were developed on the basis of multi-states feedback of the system and state observers were usually needed. Moreover, model parameters of the machining process (mass, damping and stiffness) were required in existing active controllers. In this study, an active sliding mode controller, which employs a dynamic output feedback sliding surface for the unmatched condition and an adaptive law for disturbance estimation, is designed, analyzed, and validated for chatter suppression in turning process. Only displacement measurement is required by this approach. Other sensors and state observers are not needed. Moreover, it facilitates a rapid implementation since the designed controller is established without using model parameters of the turning process. Theoretical analysis, numerical simulations and experiments on a computer numerical control (CNC) lathe are presented. It shows that the chatter can be substantially attenuated and the chatter-free region can be significantly expanded with the presented method.

Availability: A Metric for Nucleic Acid Strand Displacement Systems

PubMed Central

2016-01-01

DNA strand displacement systems have transformative potential in synthetic biology. While powerful examples have been reported in DNA nanotechnology, such systems are plagued by leakage, which limits network stability, sensitivity, and scalability. An approach to mitigate leakage in DNA nanotechnology, which is applicable to synthetic biology, is to introduce mismatches to complementary fuel sequences at key locations. However, this method overlooks nuances in the secondary structure of the fuel and substrate that impact the leakage reaction kinetics in strand displacement systems. In an effort to quantify the impact of secondary structure on leakage, we introduce the concepts of availability and mutual availability and demonstrate their utility for network analysis. Our approach exposes vulnerable locations on the substrate and quantifies the secondary structure of fuel strands. Using these concepts, a 4-fold reduction in leakage has been achieved. The result is a rational design process that efficiently suppresses leakage and provides new insight into dynamic nucleic acid networks. PMID:26875531

Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks.

PubMed

Jiang, J H; He, Z; Peng, Y L; Jin, W D; Wang, Z; Han, R W; Chang, M; Wang, R

2015-09-01

Kisspeptin (KP), the endogenous ligand of GPR54, is a recently discovered neuropeptide shown to be involved in regulating reproductive system, anxiety-related behavior, locomotion, food intake, and suppression of metastasis across a range of cancers. KP is transcribed within the hippocampus, and GPR54 has been found in the amygdala and hippocampus, suggesting that KP might be involved in mediating learning and memory. However, the role of KP in cognition was largely unclear. Here, we investigated the role of KP-13, one of the endogenous active isoforms, in memory processes, and determined whether KP-13 could mitigate memory impairment induced by Aβ1-42 in mice, using novel object recognition (NOR) and object location recognition (OLR) tasks. Intracerebroventricular (i.c.v.) infusion of KP-13 (2μg) immediately after training not only facilitated memory formation, but also prolonged memory retention in both tasks. The memory-improving effects of KP-13 could be blocked by the GPR54 receptor antagonist, kisspeptin-234 (234), and GnRH receptors antagonist, Cetrorelix, suggesting pharmacological specificity. Then the memory-enhancing effects were also presented after infusion of KP-13 into the hippocampus. Moreover, we found that i.c.v. injection of KP-13 was able to reverse the memory impairment induced by Aβ1-42, which was inhibited by 234. To sum up, the results of our work indicate that KP-13 could facilitate memory formation and prolong memory retention through activation of the GPR54 and GnRH receptors, and suppress memory-impairing effect of Aβ1-42 through activation of the GPR54, suggesting that KP-13 may be a potential drug for enhancing memory and treating Alzheimer's disease. Copyright © 2015 Elsevier Inc. All rights reserved.

Oceanographic, Air-sea Interaction, and Environmental Aspects of Artificial Upwelling Produced by Wave-Inertia Pumps for Potential Hurricane Intensity Mitigation

NASA Astrophysics Data System (ADS)

Soloviev, A.; Dean, C.

2017-12-01

The artificial upwelling system consisting of the wave-inertia pumps driven by surface waves can produce flow of cold deep water to the surface. One of the recently proposed potential applications of the artificial upwelling system is the hurricane intensity mitigation. Even relatively small reduction of intensity may provide significant benefits. The ocean heat content (OHC) is the "fuel" for hurricanes. The OHC can be reduced by mixing of the surface layer with the cold water produced by wave-inertia pumps. Implementation of this system for hurricane mitigation has several oceanographic and air-sea interaction aspects. The cold water brought to the surface from a deeper layer has higher density than the surface water and, therefore, tends to sink back down. The mixing of the cold water produced by artificial upwelling depends on environmental conditions such as stratification, regional ocean circulation, and vertical shear. Another aspect is that as the sea surface temperature drops below the air temperature, the stable stratification develops in the atmospheric boundary layer. The stable atmospheric stratification suppresses sensible and latent heat air-sea fluxes and reduces the net longwave irradiance from the sea surface. As a result, the artificial upwelling may start increasing the OHC (though still reducing the sea surface temperature). In this work, the fate of the cold water in the stratified environment with vertical shear has been studied using computational fluid dynamics (CFD) tools. A 3D large eddy simulation model is initialized with observational temperature, salinity, and current velocity data from a sample location in the Straits of Florida. A periodic boundary condition is set along the direction of the current, which allows us to simulate infinite fetch. The model results indicate that the cold water brought to the sea surface by a wave-inertia pump forms a convective jet. This jet plunges into the upper ocean mixed layer and penetrates the thermocline. On the way down, the jet partially mixes with the surrounding water reducing the temperature of the upper ocean. The OHC thus can either reduce or increase, depending on the wave-inertia pump parameters. Based on the model results, we discuss feasibility of the implementation of the artificial upwelling system for hurricane intensity mitigation.

Comparison of three chromatographic techniques for the detection of mitragynine and other indole and oxindole alkaloids in mitragyna speciosa (Kratom) plants

USDA-ARS?s Scientific Manuscript database

Leaves of the Southeast Asian plant Mitragyna speciosa (kratom) are used to suppress pain and mitigate opioid withdrawal syndromes. The potential threat of abuse and ready availability of this uncontrolled psychoactive plant material in the U.S. have led to the need for improved analytical technique...

Mechanical restoration of California mixed-conifer forests: does it matter which trees are cut?

Treesearch

Jessica Miesel; Ralph Boerner; Carl Skinner

2009-01-01

The montane ecosystems of northern California have been subjected to repeated manipulation and active fire suppression for over a century, resulting in changes in community structure that contribute to increased wildfire hazard. Ecosystem restoration via reduction of stand density for wildfire hazard mitigation has received substantial attention in recent years;...

Wildfire communication and climate risk mitigation

Treesearch

Robyn S. Wilson; Sarah M. McCaffrey; Eric Toman

2017-01-01

Throughout the late 19th century and most of the 20th century, risks associated with wildfire were addressed by suppressing fires as quickly as possible. However, by the 1960s, it became clear that fire exclusion policies were having adverse effects on ecological health, as well as contributing to larger and more damaging wildfires over time. Although federal fire...

Fluctuation theorems in feedback-controlled open quantum systems: Quantum coherence and absolute irreversibility

NASA Astrophysics Data System (ADS)

Murashita, Yûto; Gong, Zongping; Ashida, Yuto; Ueda, Masahito

2017-10-01

The thermodynamics of quantum coherence has attracted growing attention recently, where the thermodynamic advantage of quantum superposition is characterized in terms of quantum thermodynamics. We investigate the thermodynamic effects of quantum coherent driving in the context of the fluctuation theorem. We adopt a quantum-trajectory approach to investigate open quantum systems under feedback control. In these systems, the measurement backaction in the forward process plays a key role, and therefore the corresponding time-reversed quantum measurement and postselection must be considered in the backward process, in sharp contrast to the classical case. The state reduction associated with quantum measurement, in general, creates a zero-probability region in the space of quantum trajectories of the forward process, which causes singularly strong irreversibility with divergent entropy production (i.e., absolute irreversibility) and hence makes the ordinary fluctuation theorem break down. In the classical case, the error-free measurement ordinarily leads to absolute irreversibility, because the measurement restricts classical paths to the region compatible with the measurement outcome. In contrast, in open quantum systems, absolute irreversibility is suppressed even in the presence of the projective measurement due to those quantum rare events that go through the classically forbidden region with the aid of quantum coherent driving. This suppression of absolute irreversibility exemplifies the thermodynamic advantage of quantum coherent driving. Absolute irreversibility is shown to emerge in the absence of coherent driving after the measurement, especially in systems under time-delayed feedback control. We show that absolute irreversibility is mitigated by increasing the duration of quantum coherent driving or decreasing the delay time of feedback control.

Fast Acting Eddy Current Driven Valve for Massive Gas Injection on ITER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lyttle, Mark S; Baylor, Larry R; Carmichael, Justin R

2015-01-01

Tokamak plasma disruptions present a significant challenge to ITER as they can result in intense heat flux, large forces from halo and eddy currents, and potential first-wall damage from the generation of multi-MeV runaway electrons. Massive gas injection (MGI) of high Z material using fast acting valves is being explored on existing tokamaks and is planned for ITER as a method to evenly distribute the thermal load of the plasma to prevent melting, control the rate of the current decay to minimize mechanical loads, and to suppress the generation of runaway electrons. A fast acting valve and accompanying power supplymore » have been designed and first test articles produced to meet the requirements for a disruption mitigation system on ITER. The test valve incorporates a flyer plate actuator similar to designs deployed on TEXTOR, ASDEX upgrade, and JET [1 3] of a size useful for ITER with special considerations to mitigate the high mechanical forces developed during actuation due to high background magnetic fields. The valve includes a tip design and all-metal valve stem sealing for compatibility with tritium and high neutron and gamma fluxes.« less

Smokey comes of age: Unmanned aerial systems for fire management

USGS Publications Warehouse

Twidwell, Dirac; Allen, Craig R.; Detweiler, Carrick; Higgins, James; Laney, Christian; Elbaum, Sebastian

2016-01-01

During the past century, fire management has focused on techniques both to protect human communities from catastrophic wildfire and to maintain fire-dependent ecological systems. However, despite a large and increasing allocation of resources and personnel to achieve these goals, fire management objectives at regional to global scales are not being met. Current fire management techniques are clearly inadequate for the challenges faced by fire managers, and technological innovations are needed. Advances in unmanned aerial systems (UAS) technology provide opportunities for innovation in fire management and science. In many countries, fire management organizations are beginning to explore the potential of UAS for monitoring fires. We have taken the next step and developed a prototype that can precisely ignite fires as part of wildfire suppression tactics or prescribed fires (fire intentionally ignited within predetermined conditions to reduce hazardous fuels, improve habitat, or mitigate for large wildfires). We discuss the potential for these technologies to benefit fire management activities, while acknowledging the sizeable sociopolitical barriers that prevent their immediate broad application.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raymond, David W.; Blankenship, Douglas A.; Buerger, Stephen

The dynamic stability of deep drillstrings is challenged by an inability to impart controllability with ever-changing conditions introduced by geology, depth, structural dynamic properties and operating conditions. A multi-organizational LDRD project team at Sandia National Laboratories successfully demonstrated advanced technologies for mitigating drillstring vibrations to improve the reliability of drilling systems used for construction of deep, high-value wells. Using computational modeling and dynamic substructuring techniques, the benefit of controllable actuators at discrete locations in the drillstring is determined. Prototype downhole tools were developed and evaluated in laboratory test fixtures simulating the structural dynamic response of a deep drillstring. A laboratory-basedmore » drilling applicability demonstration was conducted to demonstrate the benefit available from deployment of an autonomous, downhole tool with self-actuation capabilities in response to the dynamic response of the host drillstring. A concept is presented for a prototype drilling tool based upon the technical advances. The technology described herein is the subject of U.S. Patent Application No. 62219481, entitled "DRILLING SYSTEM VIBRATION SUPPRESSION SYSTEMS AND METHODS", filed September 16, 2015.« less

RADON MITIGATION IN SCHOOLS: CASE STUDIES OF RADON MITIGATION SYSTEMS INSTALLED BY EPA IN FOUR MARYLAND SCHOOLS ARE PRESENTED

EPA Science Inventory

The first part of this two-part paper discusses radon entry into schools, radon mitigation approaches for schools, and school characteristics (e.g., heating, ventilation, and air-conditioning -- HVAC-- system design and operation) that influence radon entry and mitigation system ...

Remote electrical arc suppression by laser filamentation.

PubMed

Schubert, Elise; Mongin, Denis; Kasparian, Jérôme; Wolf, Jean-Pierre

2015-11-02

We investigate the interaction of narrow plasma channels formed in the filamentation of ultrashort laser pulses, with a DC high voltage. The laser filaments prevent electrical arcs by triggering corona that neutralize the high-voltage electrodes. This phenomenon, that relies on the electric field modulation and free electron release around the filament, opens new prospects to lightning and over-voltage mitigation.

Mitigating Wildfire Risk in the Wildland Urban Interface: The Role of Regulations

Treesearch

Cheryl R. Renner; Margaret Reams; Terry Haines

2006-01-01

The growth of residential communities within forest areas throughout the country, and particularly in the West, has increased the danger to life and property from uncontrolled wildfire. The conflict of permanent residential settlements built next to a fire-adapted ecosystem has been further exacerbated by 100 years of fire suppression and an extended drought in the...

Structure-level fuel load assessment in the wildland-urban interface: a fusion of airborne laser scanning and spectral remote-sensing methodologies

Treesearch

Nicholas S. Skowronski; Scott Haag; Jim Trimble; Kenneth L. Clark; Michael R. Gallagher; Richard G. Lathrop

2015-01-01

Large-scale fuel assessments are useful for developing policy aimed at mitigating wildfires in the wildland-urban interface (WUI), while finer-scale characterisation is necessary for maximising the effectiveness of fuel reduction treatments and directing suppression activities. We developed and tested an objective, consistent approach for characterising hazardous fuels...

Long-term impacts of prescribed fire on stand structure, growth, mortality, and individual tree vigor in Pinus resinosa forests

Treesearch

Sawyer S. Scherer; Anthony W. D' Amato; Christel C. Kern; Brian J. Palik; Matthew B. Russell

2016-01-01

Prescribed fire is increasingly being viewed as a valuable tool for mitigating the ecological consequences of long-term fire suppression within fire-adapted forest ecosystems. While the use of burning treatments in northern temperate conifer forests has at times received considerable attention, the long-term (>10 years) effects on forest structure and...

Management of forest fires to maximize carbon sequestration in temperate and boreal forests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guggenheim, D.E.

1996-12-31

This study examines opportunities for applying prescribed burning strategies to forest stands to enhance net carbon sequestration and compared prescribed burning strategies with more conventional forestry-based climate change mitigation alternatives, including fire suppression and afforestation. Biomass burning is a major contributor to greenhouse gas accumulation in the atmosphere. Biomass burning has increased by 50% since 1850. Since 1977, the annual extent of burning in the northern temperate and boreal forests has increased dramatically, from six- to nine-fold. Long-term suppression of fires in North America, Russia, and other parts of the world has led to accumulated fuel load and an increasemore » in the destructive power of wildfires. Prescribed burning has been used successfully to reduce the destructiveness of wildfires. However, across vast areas of Russia and other regions, prescribed burning is not a component of forest management practices. Given these factors and the sheer size of the temperate-boreal carbon sink, increasing attention is being focused on the role of these forests in mitigating climate change, and the role of fire management strategies, such as prescribed burning, which could work alongside more conventional forestry-based greenhouse gas offset strategies, such as afforestation.« less

Plasma Density Effects on Toroidal Flow Stabilization of Edge Localized Modes

NASA Astrophysics Data System (ADS)

Cheng, Shikui; Zhu, Ping; Banerjee, Debabrata

2016-10-01

Recent EAST experiments have demonstrated mitigation and suppression of edge localized modes (ELMs) with toroidal rotation flow in higher collisionality regime, suggesting potential roles of plasma density. In this work, the effects of plasma density on the toroidal flow stabilization of the high- n edge localized modes have been extensively studied in linear calculations for a circular-shaped limiter H-mode tokamak, using the initial-value extended MHD code NIMROD. In the single MHD model, toroidal flow has a weak stabilizing effects on the high- n modes. Such a stabilization, however, can be significantly enhanced with the increase in plasma density. Furthermore, our calculations show that the enhanced stabilization of high- n modes from toroidal flow with higher edge plasma density persists in the 2-fluid MHD model. These findings may explain the ELM mitigation and suppression by toroidal rotation in higher collisionality regime due to the enhancement of plasma density obtained in EAST experiment. Supported by the National Magnetic Confinement Fusion Program of China under Grant Nos. 2014GB124002 and 2015GB101004, the 100 Talent Program and the President International Fellowship Initiative of Chinese Academy of Sciences.

MR damping system on Dongting Lake cable-stayed bridge

NASA Astrophysics Data System (ADS)

Chen, Z. Q.; Wang, X. Y.; Ko, J. M.; Ni, Y. Q.; Spencer, Billie F., Jr.; Yang, G.

2003-08-01

The Dongting Lake Bridge is a cable-stayed bridge crossing the Dongting Lake where it meets the Yangtze River in southern central China. After this bridge was completed in 1999, its cables were observed to be sensitive to rain-wind-induced vibration, especially under adverse weather conditions of both rain and wind. To investigate the possibility of using MR damping systems to reduce cable vibration, a joint project between the Central South University of China and the Hong Kong Polytechnic University was conducted. Based on the promising research results, the bridge authority decided to install MR damping systems on the longest 156 stay cables. The installation started in July 2001 and finished in June 2002, making it the world's first application of MR dampers on cable-stayed bridge to suppress the rain-wind-induced cable vibration. As a visible and permanent aspect of bridge, the MR damping system must be aesthetically pleasing, reliable, durable, easy to maintain, as well as effective in vibration mitigation. Substantial work was done to meet these requirements. This paper describes the implementation of MR damping systems for cable vibration reduction.

On compensation of four wave mixing effect in dispersion managed hybrid WDM-OTDM multicast overlay system with optical phase conjugation modules

NASA Astrophysics Data System (ADS)

Singh, Sukhbir; Singh, Surinder

2017-11-01

This paper investigated the effect of FWM and its suppression using optical phase conjugation modules in dispersion managed hybrid WDM-OTDM multicast overlay system. Interaction between propagating wavelength signals at higher power level causes new FWM component generation that can significant limit the system performance. OPC module consists of the pump signal and 0.6 km HNLF implemented in midway of optical link to generate destructive phase FWM components. Investigation revealed that by use of even OPC module in optical link reduces the FWM power and mitigate the interaction between wavelength signals at variable signal input power, dispersion parameter (β2) and transmission distance. System performance comparison is also made between without DM-OPC module, with DM and with DM-OPC module in scenario of FWM tolerance. The BER performance of hybrid WDM-OTDM multicast system using OPC module is improved by multiplication factor of 2 as comparable to dispersion managed and coverage distance is increased by factor of 2 as in Singh and Singh (2016).

H2S: a universal defense against antibiotics in bacteria.

PubMed

Shatalin, Konstantin; Shatalina, Elena; Mironov, Alexander; Nudler, Evgeny

2011-11-18

Many prokaryotic species generate hydrogen sulfide (H(2)S) in their natural environments. However, the biochemistry and physiological role of this gas in nonsulfur bacteria remain largely unknown. Here we demonstrate that inactivation of putative cystathionine β-synthase, cystathionine γ-lyase, or 3-mercaptopyruvate sulfurtransferase in Bacillus anthracis, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli suppresses H(2)S production, rendering these pathogens highly sensitive to a multitude of antibiotics. Exogenous H(2)S suppresses this effect. Moreover, in bacteria that normally produce H(2)S and nitric oxide, these two gases act synergistically to sustain growth. The mechanism of gas-mediated antibiotic resistance relies on mitigation of oxidative stress imposed by antibiotics.

Enhancing nuclear quadrupole resonance (NQR) signature detection leveraging interference suppression algorithms

NASA Astrophysics Data System (ADS)

DeBardelaben, James A.; Miller, Jeremy K.; Myrick, Wilbur L.; Miller, Joel B.; Gilbreath, G. Charmaine; Bajramaj, Blerta

2012-06-01

Nuclear quadrupole resonance (NQR) is a radio frequency (RF) magnetic spectroscopic technique that has been shown to detect and identify a wide range of explosive materials containing quadrupolar nuclei. The NQR response signal provides a unique signature of the material of interest. The signal is, however, very weak and can be masked by non-stationary RF interference (RFI) and thermal noise, limiting detection distance. In this paper, we investigate the bounds on the NQR detection range for ammonium nitrate. We leverage a low-cost RFI data acquisition system composed of inexpensive B-field sensing and commercial-off-the-shelf (COTS) software-defined radios (SDR). Using collected data as RFI reference signals, we apply adaptive filtering algorithms to mitigate RFI and enable NQR detection techniques to approach theoretical range bounds in tactical environments.

77 FR 43100 - Privacy Act of 1974; Department of Homeland Security, Federal Emergency Management Agency-009...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-23

... Information System (NEMIS)--Mitigation (MT) Electronic Grants Management System of Records,'' and retitle it... Information System (NEMIS)--Mitigation (MT) Electronic Grants Management System of Records (69 FR 75079... Management Information System (NEMIS)--Mitigation (MT) Electronic Grants Management System (NEMIS--MT eGrants...

Groups of bats improve sonar efficiency through mutual suppression of pulse emissions.

PubMed

Jarvis, Jenna; Jackson, William; Smotherman, Michael

2013-01-01

How bats adapt their sonar behavior to accommodate the noisiness of a crowded day roost is a mystery. Some bats change their pulse acoustics to enhance the distinction between theirs and another bat's echoes, but additional mechanisms are needed to explain the bat sonar system's exceptional resilience to jamming by conspecifics. Variable pulse repetition rate strategies offer one potential solution to this dynamic problem, but precisely how changes in pulse rate could improve sonar performance in social settings is unclear. Here we show that bats decrease their emission rates as population density increases, following a pattern that reflects a cumulative mutual suppression of each other's pulse emissions. Playback of artificially-generated echolocation pulses similarly slowed emission rates, demonstrating that suppression was mediated by hearing the pulses of other bats. Slower emission rates did not support an antiphonal emission strategy but did reduce the relative proportion of emitted pulses that overlapped with another bat's emissions, reducing the relative rate of mutual interference. The prevalence of acoustic interferences occurring amongst bats was empirically determined to be a linear function of population density and mean emission rates. Consequently as group size increased, small reductions in emission rates spread across the group partially mitigated the increase in interference rate. Drawing on lessons learned from communications networking theory we show how modest decreases in pulse emission rates can significantly increase the net information throughput of the shared acoustic space, thereby improving sonar efficiency for all individuals in a group. We propose that an automated acoustic suppression of pulse emissions triggered by bats hearing each other's emissions dynamically optimizes sonar efficiency for the entire group.

Groups of bats improve sonar efficiency through mutual suppression of pulse emissions

PubMed Central

Jarvis, Jenna; Jackson, William; Smotherman, Michael

2013-01-01

How bats adapt their sonar behavior to accommodate the noisiness of a crowded day roost is a mystery. Some bats change their pulse acoustics to enhance the distinction between theirs and another bat's echoes, but additional mechanisms are needed to explain the bat sonar system's exceptional resilience to jamming by conspecifics. Variable pulse repetition rate strategies offer one potential solution to this dynamic problem, but precisely how changes in pulse rate could improve sonar performance in social settings is unclear. Here we show that bats decrease their emission rates as population density increases, following a pattern that reflects a cumulative mutual suppression of each other's pulse emissions. Playback of artificially-generated echolocation pulses similarly slowed emission rates, demonstrating that suppression was mediated by hearing the pulses of other bats. Slower emission rates did not support an antiphonal emission strategy but did reduce the relative proportion of emitted pulses that overlapped with another bat's emissions, reducing the relative rate of mutual interference. The prevalence of acoustic interferences occurring amongst bats was empirically determined to be a linear function of population density and mean emission rates. Consequently as group size increased, small reductions in emission rates spread across the group partially mitigated the increase in interference rate. Drawing on lessons learned from communications networking theory we show how modest decreases in pulse emission rates can significantly increase the net information throughput of the shared acoustic space, thereby improving sonar efficiency for all individuals in a group. We propose that an automated acoustic suppression of pulse emissions triggered by bats hearing each other's emissions dynamically optimizes sonar efficiency for the entire group. PMID:23781208

Structural control and health monitoring of building structures with unknown ground excitations: Experimental investigation

NASA Astrophysics Data System (ADS)

He, Jia; Xu, You-Lin; Zhan, Sheng; Huang, Qin

2017-03-01

When health monitoring system and vibration control system both are required for a building structure, it will be beneficial and cost-effective to integrate these two systems together for creating a smart building structure. Recently, on the basis of extended Kalman filter (EKF), a time-domain integrated approach was proposed for the identification of structural parameters of the controlled buildings with unknown ground excitations. The identified physical parameters and structural state vectors were then utilized to determine the control force for vibration suppression. In this paper, the possibility of establishing such a smart building structure with the function of simultaneous damage detection and vibration suppression was explored experimentally. A five-story shear building structure equipped with three magneto-rheological (MR) dampers was built. Four additional columns were added to the building model, and several damage scenarios were then simulated by symmetrically cutting off these columns in certain stories. Two sets of earthquakes, i.e. Kobe earthquake and Northridge earthquake, were considered as seismic input and assumed to be unknown during the tests. The structural parameters and the unknown ground excitations were identified during the tests by using the proposed identification method with the measured control forces. Based on the identified structural parameters and system states, a switching control law was employed to adjust the current applied to the MR dampers for the purpose of vibration attenuation. The experimental results show that the presented approach is capable of satisfactorily identifying structural damages and unknown excitations on one hand and significantly mitigating the structural vibration on the other hand.

Out-of-band and adjacent-channel interference reduction by analog nonlinear filters

NASA Astrophysics Data System (ADS)

Nikitin, Alexei V.; Davidchack, Ruslan L.; Smith, Jeffrey E.

2015-12-01

In a perfect world, we would have `brick wall' filters, no-distortion amplifiers and mixers, and well-coordinated spectrum operations. The real world, however, is prone to various types of unintentional and intentional interference of technogenic (man-made) origin that can disrupt critical communication systems. In this paper, we introduce a methodology for mitigating technogenic interference in communication channels by analog nonlinear filters, with an emphasis on the mitigation of out-of-band and adjacent-channel interference. Interference induced in a communications receiver by external transmitters can be viewed as wide-band non-Gaussian noise affecting a narrower-band signal of interest. This noise may contain a strong component within the receiver passband, which may dominate over the thermal noise. While the total wide-band interference seen by the receiver may or may not be impulsive, we demonstrate that the interfering component due to power emitted by the transmitter into the receiver channel is likely to appear impulsive under a wide range of conditions. We give an example of mechanisms of impulsive interference in digital communication systems resulting from the nonsmooth nature of any physically realizable modulation scheme for transmission of a digital (discontinuous) message. We show that impulsive interference can be effectively mitigated by nonlinear differential limiters (NDLs). An NDL can be configured to behave linearly when the input signal does not contain outliers. When outliers are encountered, the nonlinear response of the NDL limits the magnitude of the respective outliers in the output signal. The signal quality is improved in excess of that achievable by the respective linear filter, increasing the capacity of a communications channel. The behavior of an NDL, and its degree of nonlinearity, is controlled by a single parameter in a manner that enables significantly better overall suppression of the noise-containing impulsive components compared to the respective linear filter. Adaptive configurations of NDLs are similarly controlled by a single parameter and are suitable for improving quality of nonstationary signals under time-varying noise conditions. NDLs are designed to be fully compatible with existing linear devices and systems and to be used as an enhancement, or as a low-cost alternative, to the state-of-art interference mitigation methods.

Dynamic Stall Suppression Using Combustion-Powered Actuation (COMPACT)

NASA Technical Reports Server (NTRS)

Matalanis, Claude G.; Bowles, Patrick O.; Jee, Solkeun; Min, Byung-Young; Kuczek, Andrzej E.; Croteau, Paul F.; Wake, Brian E.; Crittenden, Thomas; Glezer, Ari; Lorber, Peter F.

2016-01-01

Retreating blade stall is a well-known phenomenon that limits rotorcraft speed, maneuverability, and efficiency. Airfoil dynamic stall is a simpler problem, which demonstrates many of the same flow phenomena. Combustion Powered Actuation (COMPACT) is an active flow control technology, which at the outset of this work, had been shown to mitigate static and dynamic stall at low Mach numbers. The attributes of this technology suggested strong potential for success at higher Mach numbers, but such experiments had never been conducted. The work detailed in this report documents a 3-year effort focused on assessing the effectiveness of COMPACT for dynamic stall suppression at freestream conditions up to Mach 0.5. The work done has focused on implementing COMPACT on a high-lift rotorcraft airfoil: the VR-12. This selection was made in order to ensure that any measured benefits are over and above the capabilities of state-of-the-art high-lift rotorcraft airfoils. The detailed Computational Fluid Dynamics (CFD) simulations, wind-tunnel experiments, and system-level modeling conducted have shown the following: (1) COMPACT, in its current state of development, is capable of reducing the adverse effects of deep dynamic stall at Mach numbers up to 0.4; (2) The two-dimensional (2D) CFD results trend well compared to the experiments; and (3) Implementation of the CFD results into a system-level model suggest that significant rotor-level benefits are possible.

Disruption mitigation and avoidance at ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Maraschek, M.; Pautasso, G.; Esposito, B.; Granucci, G.; Stober, J.; Treutterer, W.

2009-11-01

Disruptions are a major concern for tokamaks and in particular for ITER. They cause high heat loads during the thermal quench and high mechanical forces during the subsequent current quench. The generation and loss of runaway electrons (highly accelerated electrons carrying large fractions of the plasma current) can produce damage to the vessel structures. Therefore, schemes are implemented in present tokamaks to mitigate or to even avoid them. Mitigation has been proven to be effective through the injection of noble gases causing a reduction of the thermal heat load by radiation and a reduction of the mechanical forces. In addition 25% of the required density for the collisional suppression of runaways in ITER has been reached. For the trigger of the noble gas injection a locked mode detector is routinely used at ASDEX Upgrade. An extension to more complex precursors is planed. A different approach has been used for disruption avoidance by injecting ECRH triggered by the loop voltage increase before the disruption. The avoidance of an ongoing density limit disruption has been achieved when the ECRH is deposited at resonant surfaces where MHD modes, such as the m=2/n=1, occur. Present schemes for the mitigation and eventually avoidance of disruptions will be discussed.

Rapid mitigation of carrier-induced degradation in commercial silicon solar cells

NASA Astrophysics Data System (ADS)

Hallam, Brett J.; Chan, Catherine E.; Chen, Ran; Wang, Sisi; Ji, Jingjia; Mai, Ly; Abbott, Malcolm D.; Payne, David N. R.; Kim, Moonyong; Chen, Daniel; Chong, CheeMun; Wenham, Stuart R.

2017-08-01

We report on the progress for the understanding of carrier-induced degradation (CID) in p-type mono and multi-crystalline silicon (mc-Si) solar cells, and methods of mitigation. Defect formation is a key aspect to mitigating CID. Illuminated annealing can be used for both mono and mc-Si solar cells to reduce CID. The latest results of an 8-s UNSW advanced hydrogenation process applied to industrial p-type Czochralski PERC solar cells are shown with average efficiency enhancements of 1.1% absolute from eight different solar cell manufacturers. Results from three new industrial CID mitigation tools are presented, reducing CID to 0.8-1.1% relative, compared to 4.2% relative on control cells. Similar advanced hydrogenation processes can also be applied to multi-crystalline silicon passivated emitter with rear local contact (PERC) cells, however to date, the processes take longer and are less effective. Modifications to the firing processes can also suppress CID in multi-crystalline cells during subsequent illumination. The most stable results are achieved with a multi-stage process consisting of a second firing process at a reduced firing temperature, followed by extended illuminated annealing.

The biodiversity cost of carbon sequestration in tropical savanna.

PubMed

Abreu, Rodolfo C R; Hoffmann, William A; Vasconcelos, Heraldo L; Pilon, Natashi A; Rossatto, Davi R; Durigan, Giselda

2017-08-01

Tropical savannas have been increasingly viewed as an opportunity for carbon sequestration through fire suppression and afforestation, but insufficient attention has been given to the consequences for biodiversity. To evaluate the biodiversity costs of increasing carbon sequestration, we quantified changes in ecosystem carbon stocks and the associated changes in communities of plants and ants resulting from fire suppression in savannas of the Brazilian Cerrado, a global biodiversity hotspot. Fire suppression resulted in increased carbon stocks of 1.2 Mg ha -1 year -1 since 1986 but was associated with acute species loss. In sites fully encroached by forest, plant species richness declined by 27%, and ant richness declined by 35%. Richness of savanna specialists, the species most at risk of local extinction due to forest encroachment, declined by 67% for plants and 86% for ants. This loss highlights the important role of fire in maintaining biodiversity in tropical savannas, a role that is not reflected in current policies of fire suppression throughout the Brazilian Cerrado. In tropical grasslands and savannas throughout the tropics, carbon mitigation programs that promote forest cover cannot be assumed to provide net benefits for conservation.

The ITER disruption mitigation trigger: developing its preliminary design

NASA Astrophysics Data System (ADS)

Pautasso, G.; de Vries, P. C.; Humphreys, D.; Lehnen, M.; Rapson, C.; Raupp, G.; Snipes, J. A.; Treutterer, W.; Vergara-Fernandez, A.; Zabeo, L.

2018-03-01

A concept for the generation of the trigger for the ITER disruption mitigation system is described in this paper. The issuing of the trigger will be the result of a complex decision process, taken by the plasma control system, or by the central interlock system, determining that the plasma is unavoidably going to disrupt—or has disrupted—and that a fast mitigated shut-down is required. Given the redundancy of the mitigation system, the plasma control system must also formulate an injection scheme and specify when and how the injectors of the mitigation system should be activated. The parameters and the conceptual algorithms required for the configuration and generation of the trigger are discussed.

ELM control with RMP: plasma response models and the role of edge peeling response

NASA Astrophysics Data System (ADS)

Liu, Yueqiang; Ham, C. J.; Kirk, A.; Li, Li; Loarte, A.; Ryan, D. A.; Sun, Youwen; Suttrop, W.; Yang, Xu; Zhou, Lina

2016-11-01

Resonant magnetic perturbations (RMP) have extensively been demonstrated as a plausible technique for mitigating or suppressing large edge localized modes (ELMs). Associated with this is a substantial amount of theory and modelling efforts during recent years. Various models describing the plasma response to the RMP fields have been proposed in the literature, and are briefly reviewed in this work. Despite their simplicity, linear response models can provide alternative criteria, than the vacuum field based criteria, for guiding the choice of the coil configurations to achieve the best control of ELMs. The role of the edge peeling response to the RMP fields is illustrated as a key indicator for the ELM mitigation in low collisionality plasmas, in various tokamak devices.

Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression.

PubMed

Chang, Emily Yun-Chia; Stirling, Peter C

2017-01-14

Replication-transcription conflicts have been a well-studied source of genome instability for many years and have frequently been linked to defects in RNA processing. However, recent characterization of replication fork-associated proteins has revealed that defects in fork protection can directly or indirectly stabilize R-loop structures in the genome and promote transcription-replication conflicts that lead to genome instability. Defects in essential DNA replication-associated activities like topoisomerase, or the minichromosome maintenance (MCM) helicase complex, as well as fork-associated protection factors like the Fanconi anemia pathway, both appear to mitigate transcription-replication conflicts. Here, we will highlight recent advances that support the concept that normal and robust replisome function itself is a key component of mitigating R-loop coupled genome instability.

Roads impact the distribution of noxious weeds more than restoration treatments in a lodgepole pine forest in Montana, U.S.A

Treesearch

Jennifer L. Birdsall; Ward McCaughey; Justin B. Runyon

2012-01-01

A century of fire suppression has created unnaturally dense stands in many western North American forests, and silviculture treatments are being increasingly used to reduce fuels to mitigate wildfire hazards and manage insect infestations. Thinning prescriptions have the potential to restore forests to a more historically sustainable state, but land managers need to be...

Foreground Mitigation in the Epoch of Reionization

NASA Astrophysics Data System (ADS)

Chapman, Emma

2018-05-01

The EoR foregrounds can be up to three magnitudes greater than the cosmological signal we wish to detect. Multiple methods have been developed in order to extract the cosmological signal, falling roughly into three categories: foreground removal, foreground suppression and foreground avoidance. These main approaches are briefly discussed in this review and consideration taken to the future application of these methods as a multi-layered approach.

A conceptual framework for coupling the biophysical and social dimensions of wildfire to improve fireshed planning and risk mitigation

Treesearch

Jeff Kline; Alan A. Ager; Paige Fischer

2015-01-01

The need for improved methods for managing wildfire risk is becoming apparent as uncharacteristically large wildfires in the western US and elsewhere exceed government capacities for their control and suppression. We propose a coupled biophysical-social framework to managing wildfire risk that relies on wildfire simulation to identify spatial patterns of wildfire risk...

Voluntary suppression of hyperthermia-induced hyperventilation mitigates the reduction in cerebral blood flow velocity during exercise in the heat.

PubMed

Tsuji, Bun; Honda, Yasushi; Ikebe, Yusuke; Fujii, Naoto; Kondo, Narihiko; Nishiyasu, Takeshi

2015-04-15

Hyperthermia during prolonged exercise leads to hyperventilation, which can reduce arterial CO2 pressure (PaCO2 ) and, in turn, cerebral blood flow (CBF) and thermoregulatory response. We investigated 1) whether humans can voluntarily suppress hyperthermic hyperventilation during prolonged exercise and 2) the effects of voluntary breathing control on PaCO2 , CBF, sweating, and skin blood flow. Twelve male subjects performed two exercise trials at 50% of peak oxygen uptake in the heat (37°C, 50% relative humidity) for up to 60 min. Throughout the exercise, subjects breathed normally (normal-breathing trial) or they tried to control their minute ventilation (respiratory frequency was timed with a metronome, and target tidal volumes were displayed on a monitor) to the level reached after 5 min of exercise (controlled-breathing trial). Plotting ventilatory and cerebrovascular responses against esophageal temperature (Tes) showed that minute ventilation increased linearly with rising Tes during normal breathing, whereas controlled breathing attenuated the increased ventilation (increase in minute ventilation from the onset of controlled breathing: 7.4 vs. 1.6 l/min at +1.1°C Tes; P < 0.001). Normal breathing led to decreases in estimated PaCO2 and middle cerebral artery blood flow velocity (MCAV) with rising Tes, but controlled breathing attenuated those reductions (estimated PaCO2 -3.4 vs. -0.8 mmHg; MCAV -10.4 vs. -3.9 cm/s at +1.1°C Tes; P = 0.002 and 0.011, respectively). Controlled breathing had no significant effect on chest sweating or forearm vascular conductance (P = 0.67 and 0.91, respectively). Our results indicate that humans can voluntarily suppress hyperthermic hyperventilation during prolonged exercise, and this suppression mitigates changes in PaCO2 and CBF. Copyright © 2015 the American Physiological Society.

Voluntary suppression of hyperthermia-induced hyperventilation mitigates the reduction in cerebral blood flow velocity during exercise in the heat

PubMed Central

Tsuji, Bun; Honda, Yasushi; Ikebe, Yusuke; Fujii, Naoto; Kondo, Narihiko

2015-01-01

Hyperthermia during prolonged exercise leads to hyperventilation, which can reduce arterial CO2 pressure (PaCO2) and, in turn, cerebral blood flow (CBF) and thermoregulatory response. We investigated 1) whether humans can voluntarily suppress hyperthermic hyperventilation during prolonged exercise and 2) the effects of voluntary breathing control on PaCO2, CBF, sweating, and skin blood flow. Twelve male subjects performed two exercise trials at 50% of peak oxygen uptake in the heat (37°C, 50% relative humidity) for up to 60 min. Throughout the exercise, subjects breathed normally (normal-breathing trial) or they tried to control their minute ventilation (respiratory frequency was timed with a metronome, and target tidal volumes were displayed on a monitor) to the level reached after 5 min of exercise (controlled-breathing trial). Plotting ventilatory and cerebrovascular responses against esophageal temperature (Tes) showed that minute ventilation increased linearly with rising Tes during normal breathing, whereas controlled breathing attenuated the increased ventilation (increase in minute ventilation from the onset of controlled breathing: 7.4 vs. 1.6 l/min at +1.1°C Tes; P < 0.001). Normal breathing led to decreases in estimated PaCO2 and middle cerebral artery blood flow velocity (MCAV) with rising Tes, but controlled breathing attenuated those reductions (estimated PaCO2 −3.4 vs. −0.8 mmHg; MCAV −10.4 vs. −3.9 cm/s at +1.1°C Tes; P = 0.002 and 0.011, respectively). Controlled breathing had no significant effect on chest sweating or forearm vascular conductance (P = 0.67 and 0.91, respectively). Our results indicate that humans can voluntarily suppress hyperthermic hyperventilation during prolonged exercise, and this suppression mitigates changes in PaCO2 and CBF. PMID:25632021

Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action.

PubMed

Fu, Qiang; Berbée, Maaike; Wang, Wenze; Boerma, Marjan; Wang, Junru; Schmid, Herbert A; Hauer-Jensen, Martin

2011-06-01

The somatostatin analog SOM230 has potent radioprophylactic and radiation mitigating properties that are unrelated to cytoprotection but appear to be due to suppression of secretion of pancreatic enzymes into the intestinal lumen. To determine the maximal postirradiation time window for administration, male CD2F1 mice were exposed to 8.5-11 Gy total-body radiation; SOM230 (0.5, 2 or 5 mg/kg) or vehicle was given by twice daily subcutaneous injections for 14 days, beginning 24-72 h after irradiation, and 30-day animal survival was recorded. The contribution of the gut to systemic cytokine levels was estimated by analyzing plasma samples obtained simultaneously from the portal vein and carotid artery. The effect of SOM230 on cell trypsin secretion was assessed in vitro and intestinal proteolytic activity was measured in vivo. SOM230 was associated with a 40-60% absolute improvement in overall postirradiation survival when treatment was started 48 h after irradiation and even exhibited a statistically significant survival benefit when started at 72 h. SOM230 ameliorated the radiation-induced decrease in chemokine (C-X-C motif) ligand 9 (CXCL9). SOM230 inhibited pancreatic acinar cell trypsin secretion in vitro in a dose-dependent fashion and reduced intraluminal and intestinal tissue proteolytic activity in vivo. SOM230 is an excellent radiation mitigator with a postirradiation time window in excess of 48 h. The mechanism likely involves preservation of intestinal barrier function due to decreased secretion of pancreatic enzymes into the bowel lumen.

General Suppression of Escherichia coli O157:H7 in Sand-Based Dairy Livestock Bedding▿ †

PubMed Central

Westphal, Andreas; Williams, Michele L.; Baysal-Gurel, Fulya; LeJeune, Jeffrey T.; McSpadden Gardener, Brian B.

2011-01-01

Sand bedding material is frequently used in dairy operations to reduce the occurrence of mastitis and enhance cow comfort. One objective of this work was to determine if sand-based bedding also supported the microbiologically based suppression of an introduced bacterial pathogen. Bedding samples were collected in summer, fall, and winter from various locations within a dairy operation and tested for their ability to suppress introduced populations of Escherichia coli O157:H7. All sources of bedding displayed a heat-sensitive suppressiveness to the pathogen. Differences in suppressiveness were also noted between different samples at room temperature. At just 1 day postinoculation (dpi), the recycled sand bedding catalyzed up to a 1,000-fold reduction in E. coli counts, typically 10-fold greater than the reduction achieved with other substrates, depending on the sampling date. All bedding substrates were able to reduce E. coli populations by over 10,000-fold within 7 to 15 dpi, regardless of sampling date. Terminal restriction fragment length polymorphism (T-RFLP) analysis was used to identify bacterial populations potentially associated with the noted suppression of E. coli O157:H7 in sand bedding. Eleven terminal restriction fragments (TRFs) were overrepresented in paired comparisons of suppressive and nonsuppressive specimens at multiple sampling points, indicating that they may represent environmentally stable populations of pathogen-suppressing bacteria. Cloning and sequencing of these TRFs indicated that they represent a diverse subset of bacteria, belonging to the Cytophaga-Flexibacter-Bacteroidetes, Gammaproteobacteria, and Firmicutes, only a few of which have previously been identified in livestock manure. Such data indicate that microbial suppression may be harnessed to develop new options for mitigating the risk and dispersal of zoonotic bacterial pathogens on dairy farms. PMID:21257815

Artificial light pollution: Shifting spectral wavelengths to mitigate physiological and health consequences in a nocturnal marsupial mammal.

PubMed

Dimovski, Alicia M; Robert, Kylie A

2018-05-02

The focus of sustainable lighting tends to be on reduced CO 2 emissions and cost savings, but not on the wider environmental effects. Ironically, the introduction of energy-efficient lighting, such as light emitting diodes (LEDs), may be having a great impact on the health of wildlife. These white LEDs are generated with a high content of short-wavelength 'blue' light. While light of any kind can suppress melatonin and the physiological processes it regulates, these short wavelengths are potent suppressors of melatonin. Here, we manipulated the spectral composition of LED lights and tested their capacity to mitigate the physiological and health consequences associated with their use. We experimentally investigated the impact of white LEDs (peak wavelength 448 nm; mean irradiance 2.87 W/m 2 ), long-wavelength shifted amber LEDs (peak wavelength 605 nm; mean irradiance 2.00 W/m 2 ), and no lighting (irradiance from sky glow < 0.37 × 10 -3 W/m 2 ), on melatonin production, lipid peroxidation, and circulating antioxidant capacity in the tammar wallaby (Macropus eugenii). Night-time melatonin and oxidative status were determined at baseline and again following 10 weeks exposure to light treatments. White LED exposed wallabies had significantly suppressed nocturnal melatonin compared to no light and amber LED exposed wallabies, while there was no difference in lipid peroxidation. Antioxidant capacity declined from baseline to week 10 under all treatments. These results provide further evidence that short-wavelength light at night is a potent suppressor of nocturnal melatonin. Importantly, we also illustrate that shifting the spectral output to longer wavelengths could mitigate these negative physiological impacts. © 2018 Wiley Periodicals, Inc.

Mitigating Stress Waves by using Nanofoams and Nanohoneycombs

DTIC Science & Technology

2015-02-13

local softening in a regular foam is suppressed, and bulk energy absorption is achieved. (a) Papers published in peer-reviewed journals ( N /A for none...including journal references, in the following categories: (b) Papers published in non-peer-reviewed journals ( N /A for none) Received Paper TOTAL...Inventions (DD882) Scientific Progress Please see the attachment Technology Transfer N Patent Filed in US? (5d-1) Patent Filed in Foreign Countries

Quantifying the effectiveness of conservation measures to control the spread of anthropogenic hybridization in stream salmonids: a climate adaptation case study

USGS Publications Warehouse

Al-Chokhachy, Robert K.; Muhlfeld, Clint C.; Boyer, Matthew; Jones, Leslie A.; Steed, Amber; Kershner, Jeffrey L.

2014-01-01

Quantifying the effectiveness of management actions to mitigate the effects of changing climatic conditions (i.e., climate adaptation) can be difficult, yet critical for conservation. We used population genetic data from 1984 to 2011 to assess the degree to which ambient climatic conditions and targeted suppression of sources of nonnative Rainbow Trout Oncorhynchus mykiss have influenced the spread of introgressive hybridization in native populations of Westslope Cutthroat Trout O. clarkii lewisi. We found rapid expansion in the spatial distribution and proportion of nonnative genetic admixture in hybridized populations from 1984 to 2004, but minimal change since 2004. The spread of hybridization was negatively correlated with the number of streamflow events in May that exceeded the 75th percentile of historic flows (r = −0.98) and positively correlated with August stream temperatures (r = 0.89). Concomitantly, suppression data showed a 60% decline in catch per unit effort for fish with a high proportion of Rainbow Trout admixture, rendering some uncertainty as to the relative strength of factors controlling the spread of hybridization. Our results illustrate the importance of initiating management actions to mitigate the potential effects of climate change, even where data describing the effectiveness of such actions are initially limited but the risks are severe.

RADON MITIGATION IN SCHOOLS: HVAC SYSTEMS IN SCHOOLS TEND TO HAVE A GREATER IMPACT ON RADON LEVELS THAN HVAC SYSTEMS IN HOMES

EPA Science Inventory

The first part of this two-part paper discusses radon entry into schools, radon mitigation approaches for schools, and school characteristics (e.g., heating, ventilation, and air conditioing -- HVAC-- system design and operationg) that influence radon entry and mitigation system ...

Low-Complexity Noncoherent Signal Detection for Nanoscale Molecular Communications.

PubMed

Li, Bin; Sun, Mengwei; Wang, Siyi; Guo, Weisi; Zhao, Chenglin

2016-01-01

Nanoscale molecular communication is a viable way of exchanging information between nanomachines. In this investigation, a low-complexity and noncoherent signal detection technique is proposed to mitigate the inter-symbol-interference (ISI) and additive noise. In contrast to existing coherent detection methods of high complexity, the proposed noncoherent signal detector is more practical when the channel conditions are hard to acquire accurately or hidden from the receiver. The proposed scheme employs the molecular concentration difference to detect the ISI corrupted signals and we demonstrate that it can suppress the ISI effectively. The difference in molecular concentration is a stable characteristic, irrespective of the diffusion channel conditions. In terms of complexity, by excluding matrix operations or likelihood calculations, the new detection scheme is particularly suitable for nanoscale molecular communication systems with a small energy budget or limited computation resource.

High efficiency tapered free-electron lasers with a prebunched electron beam

DOE PAGES

Emma, C.; Sudar, N.; Musumeci, P.; ...

2017-11-17

In this study we analyze the high gain, high efficiency tapered free-electron laser amplifier with a prebunched electron beam. Simple scaling laws are derived for the peak output power and extraction efficiency and verified using 1D simulations. These studies provide useful analytical expressions which highlight the benefits resulting from fine control of the initial conditions of the system, namely the initial electron beam bunching and input seed radiation. When time-dependent effects are included, the sideband instability is known to limit the radiation amplification due to particle detrapping. We discuss two different approaches to mitigate the sideband growth via 1-D timemore » dependent simulations. We find that a more aggressive taper enabled by strong prebunching and a modulation of the resonance condition are both effective methods for suppressing the sideband instability growth rate.« less

Radiation effects in reconfigurable FPGAs

NASA Astrophysics Data System (ADS)

Quinn, Heather

2017-04-01

Field-programmable gate arrays (FPGAs) are co-processing hardware used in image and signal processing. FPGA are programmed with custom implementations of an algorithm. These algorithms are highly parallel hardware designs that are faster than software implementations. This flexibility and speed has made FPGAs attractive for many space programs that need in situ, high-speed signal processing for data categorization and data compression. Most commercial FPGAs are affected by the space radiation environment, though. Problems with TID has restricted the use of flash-based FPGAs. Static random access memory based FPGAs must be mitigated to suppress errors from single-event upsets. This paper provides a review of radiation effects issues in reconfigurable FPGAs and discusses methods for mitigating these problems. With careful design it is possible to use these components effectively and resiliently.

Skin effect mitigation in laser processed multi-walled carbon nanotube/copper conductors

NASA Astrophysics Data System (ADS)

Keramatnejad, K.; Zhou, Y. S.; Gao, Y.; Rabiee Golgir, H.; Wang, M.; Jiang, L.; Silvain, J.-F.; Lu, Y. F.

2015-10-01

In this study, laser-processed multi-walled carbon nanotube (MWCNT)/Cu conductors are introduced as potential passive components to mitigate the skin effect of Cu at high frequencies (0-10 MHz). Suppressed skin effect is observed in the MWCNT/Cu conductors compared to primitive Cu. At an AC frequency of 10 MHz, a maximum AC resistance reduction of 94% was observed in a MWCNT/Cu conductor after being irradiated at a laser power density of 189 W/cm2. The reduced skin effect in the MWCNT/Cu conductors is ascribed to the presence of MWCNT channels which are insensitive to AC frequencies. The laser irradiation process is observed to play a crucial role in reducing contact resistance at the MWCNT-Cu interfaces, removing impurities in MWCNTs, and densifying MWCNT films.

Ebolavirus and Haemorrhagic Syndrome

PubMed Central

Matua, Gerald A.; Van der Wal, Dirk M.; Locsin, Rozzano C.

2015-01-01

The Ebola virus is a highly virulent, single-stranded ribonucleic acid virus which affects both humans and apes and has fast become one of the world’s most feared pathogens. The virus induces acute fever and death, with haemorrhagic syndrome occurring in up to 90% of patients. The known species within the genus Ebolavirus are Bundibugyo, Sudan, Zaïre, Reston and Taï Forest. Although endemic in Africa, Ebola has caused worldwide anxiety due to media hype and concerns about its international spread, including through bioterrorism. The high fatality rate is attributed to unavailability of a standard treatment regimen or vaccine. The disease is frightening since it is characterised by rapid immune suppression and systemic inflammatory response, causing multi-organ and system failure, shock and often death. Currently, disease management is largely supportive, with containment efforts geared towards mitigating the spread of the virus. This review describes the classification, morphology, infective process, natural ecology, transmission, epidemic patterns, diagnosis, clinical features and immunology of Ebola, including management and epidemic containment strategies. PMID:26052448

Evidence from stable isotopes and 10Be for solar system formation triggered by a low-mass supernova

PubMed Central

Banerjee, Projjwal; Qian, Yong-Zhong; Heger, Alexander; Haxton, W C

2016-01-01

About 4.6 billion years ago, some event disturbed a cloud of gas and dust, triggering the gravitational collapse that led to the formation of the solar system. A core-collapse supernova, whose shock wave is capable of compressing such a cloud, is an obvious candidate for the initiating event. This hypothesis can be tested because supernovae also produce telltale patterns of short-lived radionuclides, which would be preserved today as isotopic anomalies. Previous studies of the forensic evidence have been inconclusive, finding a pattern of isotopes differing from that produced in conventional supernova models. Here we argue that these difficulties either do not arise or are mitigated if the initiating supernova was a special type, low in mass and explosion energy. Key to our conclusion is the demonstration that short-lived 10Be can be readily synthesized in such supernovae by neutrino interactions, while anomalies in stable isotopes are suppressed. PMID:27873999

Evidence from stable isotopes and 10Be for solar system formation triggered by a low-mass supernova

DOE PAGES

Banerjee, Projjwal; Qian, Yong -Zhong; Heger, Alexander; ...

2016-11-22

About 4.6 billion years ago, some event disturbed a cloud of gas and dust, triggering the gravitational collapse that led to the formation of the solar system. A core-collapse supernova, whose shock wave is capable of compressing such a cloud, is an obvious candidate for the initiating event. This hypothesis can be tested because supernovae also produce telltale patterns of short-lived radionuclides, which would be preserved today as isotopic anomalies. Previous studies of the forensic evidence have been inconclusive, finding a pattern of isotopes differing from that produced in conventional supernova models. Here we argue that these difficulties either domore » not arise or are mitigated if the initiating supernova was a special type, low in mass and explosion energy. Key to our conclusion is the demonstration that short-lived 10Be can be readily synthesized in such supernovae by neutrino interactions, while anomalies in stable isotopes are suppressed.« less

Evidence from stable isotopes and 10Be for solar system formation triggered by a low-mass supernova

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banerjee, Projjwal; Qian, Yong -Zhong; Heger, Alexander

About 4.6 billion years ago, some event disturbed a cloud of gas and dust, triggering the gravitational collapse that led to the formation of the solar system. A core-collapse supernova, whose shock wave is capable of compressing such a cloud, is an obvious candidate for the initiating event. This hypothesis can be tested because supernovae also produce telltale patterns of short-lived radionuclides, which would be preserved today as isotopic anomalies. Previous studies of the forensic evidence have been inconclusive, finding a pattern of isotopes differing from that produced in conventional supernova models. Here we argue that these difficulties either domore » not arise or are mitigated if the initiating supernova was a special type, low in mass and explosion energy. Key to our conclusion is the demonstration that short-lived 10Be can be readily synthesized in such supernovae by neutrino interactions, while anomalies in stable isotopes are suppressed.« less

Ebolavirus and Haemorrhagic Syndrome.

PubMed

Matua, Gerald A; Van der Wal, Dirk M; Locsin, Rozzano C

2015-05-01

The Ebola virus is a highly virulent, single-stranded ribonucleic acid virus which affects both humans and apes and has fast become one of the world's most feared pathogens. The virus induces acute fever and death, with haemorrhagic syndrome occurring in up to 90% of patients. The known species within the genus Ebolavirus are Bundibugyo, Sudan, Zaïre, Reston and Taï Forest. Although endemic in Africa, Ebola has caused worldwide anxiety due to media hype and concerns about its international spread, including through bioterrorism. The high fatality rate is attributed to unavailability of a standard treatment regimen or vaccine. The disease is frightening since it is characterised by rapid immune suppression and systemic inflammatory response, causing multi-organ and system failure, shock and often death. Currently, disease management is largely supportive, with containment efforts geared towards mitigating the spread of the virus. This review describes the classification, morphology, infective process, natural ecology, transmission, epidemic patterns, diagnosis, clinical features and immunology of Ebola, including management and epidemic containment strategies.

Stem cells for murine interstitial cells of cajal suppress cellular immunity and colitis via prostaglandin E2 secretion.

PubMed

Dave, Maneesh; Hayashi, Yujiro; Gajdos, Gabriella B; Smyrk, Thomas C; Svingen, Phyllis A; Kvasha, Sergiy M; Lorincz, Andrea; Dong, Haidong; Faubion, William A; Ordog, Tamas

2015-05-01

After allogeneic transplantation, murine stem cells (SCs) for interstitial cells of Cajal (ICCs), electrical pacemaker, and neuromodulator cells of the gut, were incorporated into gastric ICC networks, indicating in vivo immunosuppression. Immunosuppression is characteristic of bone marrow- and other non-gut-derived mesenchymal stem cells (MSCs), which are emerging as potential therapeutic agents against autoimmune diseases, including inflammatory bowel disease. Therefore, we investigated whether gut-derived ICC-SCs could also mitigate experimental colitis and studied the mechanisms of ICC-SC-mediated immunosuppression in relation to MSC-induced pathways. Isolated ICC-SCs were studied by transcriptome profiling, cytokine assays, flow cytometry, mixed lymphocyte reaction, and T-cell proliferation assay. Mice with acute and chronic colitis induced by dextran sulfate sodium and T-cell transfer, respectively, were administered ICC-SCs intraperitoneally and evaluated for disease activity by clinical and pathological assessment and for ICC-SC homing by live imaging. Unlike strain-matched dermal fibroblasts, intraperitoneally administered ICC-SCs preferentially homed to the colon and reduced the severity of both acute and chronic colitis assessed by clinical and blind pathological scoring. ICC-SCs profoundly suppressed T-cell proliferation in vitro. Similar to MSCs, ICC-SCs strongly expressed cyclooxygenase 1/2 and basally secreted prostaglandin E2. Indomethacin, a cyclooxygenase inhibitor, countered the ICC-SC-mediated suppression of T-cell proliferation. In contrast, we found no role for regulatory T-cell-, programmed death receptor-, and transforming growth factor-β-mediated mechanisms reported in MSCs; and transcriptome profiling did not support a relationship between ICC-SCs and MSCs. Murine ICC-SCs belong to a class different from MSCs and potently mitigate experimental colitis via prostaglandin E2-mediated immunosuppression. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation.

PubMed

Chaudhary, Vidyanath; Zhang, Shuo; Yuen, Kit-San; Li, Chuan; Lui, Pak-Yin; Fung, Sin-Yee; Wang, Pei-Hui; Chan, Chi-Ping; Li, Dexin; Kok, Kin-Hang; Liang, Mifang; Jin, Dong-Yan

2015-11-01

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to be fully understood. Here, we showed the suppression of both type I and type III IFN signalling by SFTSV NSs protein is mediated through inhibition of STAT1 phosphorylation and activation. Infection with live SFTSV or expression of NSs potently suppressed IFN-stimulated genes but not NFkB activation. NSs was capable of counteracting the activity of IFN-α1, IFN-β, IFN-λ1 and IFN-λ2. Mechanistically, NSs associated with STAT1 and STAT2, mitigated IFN-β-induced phosphorylation of STAT1 at S727, and reduced the expression and activity of STAT1 protein in IFN-β-treated cells, resulting in the inhibition of STAT1 and STAT2 recruitment to IFNstimulated promoters. Taken together, SFTSV NSs protein is an IFN antagonist that suppresses phosphorylation and activation of STAT1.

The biodiversity cost of carbon sequestration in tropical savanna

PubMed Central

Abreu, Rodolfo C. R.; Hoffmann, William A.; Vasconcelos, Heraldo L.; Pilon, Natashi A.; Rossatto, Davi R.; Durigan, Giselda

2017-01-01

Tropical savannas have been increasingly viewed as an opportunity for carbon sequestration through fire suppression and afforestation, but insufficient attention has been given to the consequences for biodiversity. To evaluate the biodiversity costs of increasing carbon sequestration, we quantified changes in ecosystem carbon stocks and the associated changes in communities of plants and ants resulting from fire suppression in savannas of the Brazilian Cerrado, a global biodiversity hotspot. Fire suppression resulted in increased carbon stocks of 1.2 Mg ha−1 year−1 since 1986 but was associated with acute species loss. In sites fully encroached by forest, plant species richness declined by 27%, and ant richness declined by 35%. Richness of savanna specialists, the species most at risk of local extinction due to forest encroachment, declined by 67% for plants and 86% for ants. This loss highlights the important role of fire in maintaining biodiversity in tropical savannas, a role that is not reflected in current policies of fire suppression throughout the Brazilian Cerrado. In tropical grasslands and savannas throughout the tropics, carbon mitigation programs that promote forest cover cannot be assumed to provide net benefits for conservation. PMID:28875172

[The negative side of emotions: addiction to drugs of abuse].

PubMed

Contreras, M; Ceric, F; Torrealba, F

According to the model of emotions, feelings have their origin in the conscious perception of body changes produced in response to an emotional stimulus. These changes are perceived thanks to the fact that they are represented in the brain by the interoceptive system. During abstinence, addicts experience intense feelings of ill-being that drive them to consume drugs. The purpose of this review is to discuss the role played by the interoceptive system, and more especially the insular cortex, in the perception of the negative feelings that characterise abstinence. The continuous processing of interoceptive signals in the insular cortex is what accounts for the conscious appreciation of the body changes that accompany an emotional state. Temporary inactivation of the insular cortex suppresses the search for drugs in addicted rats. Neuroimaging studies reveal an increase in the neuronal activity in the insular cortex and in other areas of the brain while addicts are experiencing the craving to consume drugs. Likewise, nicotine addicts who suffer a brain injury that affects the insular cortex give up smoking easily because they lose the desire to do it. The temporary suppression of neuronal activity in the insular cortex in human addicts by means of non-invasive techniques could be a new therapy to treat the craving to consume drugs. The insular cortex is essential in the perception of the emotional states and in orienting behaviour to match the needs of the body. New therapies that have the insular cortex as their target could be developed to mitigate craving.

Mitigation of 3-Monochloro-1,2-propanediol Ester Formation by Radical Scavengers.

PubMed

Zhang, Hai; Jin, Pengwei; Zhang, Min; Cheong, Ling-Zhi; Hu, Peng; Zhao, Yue; Yu, Liangli; Wang, Yong; Jiang, Yuanrong; Xu, Xuebing

2016-07-27

The present study investigated the possible mechanism of free radical scavengers on mitigation of 3-monochloro-1,2-propanediol (3-MCPD) fatty acid ester formation in vegetable oils. The electron spin resonance investigation showed that the concentration of free radicals could be clearly decreased in 1,2-distearoyl-sn-glycerol (DSG) samples by all four antioxidants (l-ascorbyl palmitate, α-tocopherol, lipophilic tea polyphenols, and rosemary extract) at 120 °C for 20 min under a N2 atmosphere. Moreover, the rosemary extract exhibited the highest inhibition efficiency. The Fourier transform infrared spectroscopy examination of DSG with α-tocopherol at 25 and 120 °C revealed that α-tocopherol could prevent the involvement of an ester carbonyl group of DSG in forming the cyclic acyloxonium free radical intermediate. Furthermore, the ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry analysis showed that α-tocopherol could suppress the formation of 3-MCPD di- and monoesters. Finally, the four antioxidants could decrease 3-MCPD esters in the palm oil during deodorization. Particularly, the rosemary extract also showed the highest efficiency in 3-MCPD ester mitigation.

Innovative Solid State Infrared Laser Devices

DTIC Science & Technology

2010-12-01

The polycrystalline, 8.9x7.0x3.0 mm3 (LxWxH) Cr2+:ZnSe gain element was installed at the Brewster angle of 67.7º for horizontal polarization...8 3.1.4 Waveguide devices for thermal lensing mitigation ................................... 10...power of Cr2+:ZnSe, modelocked operation of Cr2+:ZnSe and suppression of thermal lensing effects. 3.1.1 Cr2+:ZnSe power scaling We achieved first

RADON MITIGATION IN SCHOOLS: HVAC SYTEMS IN SCHOOLS TEND TO HAVE A GREATER IMPACT ON RADON LEVELS THAN HVAC SYSTEMS IN HOMES

EPA Science Inventory

The first part of this two-part paper discusses radon entry into schools, radon mitigation approaches for schools, and school characteristics (e.g., heating, ventilation, and air conditioing -- HVAC-- system design and operationg) that influence radon entry and mitigation system ...

Surface Conduction in III-V Semiconductor Infrared Detector Materials

NASA Astrophysics Data System (ADS)

Sidor, Daniel Evan

III-V semiconductors are increasingly used to produce high performance infrared photodetectors; however a significant challenge inherent to working with these materials is presented by unintended electrical conduction pathways that form along their surfaces. Resulting leakage currents contribute to system noise and are ineffectively mitigated by device cooling, and therefore limit ultimate performance. When the mechanism of surface conduction is understood, the unipolar barrier device architecture offers a potential solution. III-V bulk unipolar barrier detectors that effectively suppress surface leakage have approached the performance of the best II-VI pn-based structures. This thesis begins with a review of empirically determined Schottky barrier heights and uses this information to present a simple model of semiconductor surface conductivity. The model is validated through measurements of degenerate n-type surface conductivity on InAs pn junctions, and non-degenerate surface conductivity on GaSb pn junctions. It is then extended, along with design principles inspired by the InAs-based nBn detector, to create a flat-band pn-based unipolar barrier detector possessing a conductive surface but free of detrimental surface leakage current. Consideration is then given to the relative success of these and related bulk detectors in suppressing surface leakage when compared to analogous superlattice-based designs, and general limitations of unipolar barriers in suppressing surface leakage are proposed. Finally, refinements to the molecular beam epitaxy crystal growth techniques used to produce InAs-based unipolar barrier heterostructure devices are discussed. Improvements leading to III-V device performance well within an order of magnitude of the state-of-the-art are demonstrated.

Suppressing iron oxide nanoparticle toxicity by vascular targeted antioxidant polymer nanoparticles.

PubMed

Cochran, David B; Wattamwar, Paritosh P; Wydra, Robert; Hilt, J Zach; Anderson, Kimberly W; Eitel, Richard E; Dziubla, Thomas D

2013-12-01

The biomedical use of superparamagnetic iron oxide nanoparticles has been of continued interest in the literature and clinic. Their ability to be used as contrast agents for imaging and/or responsive agents for remote actuation makes them exciting materials for a wide range of clinical applications. Recently, however, concern has arisen regarding the potential health effects of these particles. Iron oxide toxicity has been demonstrated in in vivo and in vitro models, with oxidative stress being implicated as playing a key role in this pathology. One of the key cell types implicated in this injury is the vascular endothelial cells. Here, we report on the development of a targeted polymeric antioxidant, poly(trolox ester), nanoparticle that can suppress oxidative damage. As the polymer undergoes enzymatic hydrolysis, active trolox is locally released, providing a long term protection against pro-oxidant agents. In this work, poly(trolox) nanoparticles are targeted to platelet endothelial cell adhesion molecules (PECAM-1), which are able to bind to and internalize in endothelial cells and provide localized protection against the cytotoxicity caused by iron oxide nanoparticles. These results indicate the potential of using poly(trolox ester) as a means of mitigating iron oxide toxicity, potentially expanding the clinical use and relevance of these exciting systems. Copyright © 2013 Elsevier Ltd. All rights reserved.

Effect of ferrihydrite biomineralization on methanogenesis in an anaerobic incubation from paddy soil

NASA Astrophysics Data System (ADS)

Zhuang, Li; Xu, Jielong; Tang, Jia; Zhou, Shungui

2015-05-01

Microbial reduction of Fe(III) can be one of the major factors controlling methane production from anaerobic sedimentary environments, such as paddy soils and wetlands. Although secondary iron mineralization following Fe(III) reduction is a process that occurs naturally over time, it has not yet been considered in methanogenic systems. This study performed a long-term anaerobic incubation of a paddy soil and ferrihydrite-supplemented soil cultures to investigate methanogenesis during ferrihydrite biomineralization. The results revealed that the long-term effect of ferrihydrite on methanogenesis may be enhancement rather than suppression documented in previous studies. During initial microbial ferrihydrite reduction, methanogenesis was suppressed; however, the secondary minerals of magnetite formation was simultaneous with facilitated methanogenesis in terms of average methane production rate and acetate utilization rate. In the phase of magnetite formation, microbial community analysis revealed a strong stimulation of the bacterial Geobacter, Bacillus, and Sedimentibacter and the archaeal Methanosarcina in the ferrihydrite-supplemented cultures. Direct electric syntrophy between Geobacter and Methanosarcina via conductive magnetite is the plausible mechanism for methanogenesis acceleration along with magnetite formation. Our data suggested that a change in iron mineralogy might affect the conversion of anaerobic organic matter to methane and might provide a fresh perspective on the mitigation of methane emissions from paddy soils by ferric iron fertilization.

Evaporation suppression from reservoirs using floating covers: Lab scale wind-tunnel observations and mechanistic model predictions

NASA Astrophysics Data System (ADS)

Or, Dani; Lehmann, Peter; Aminzadeh, Milad; Sommer, Martina; Wey, Hannah; Krentscher, Christiane; Wunderli, Hans; Breitenstein, Daniel

2017-04-01

The competition over dwindling fresh water resources is expected to intensify with projected increase in human population in arid regions, expansion of irrigated land and changes in climate and drought patterns. The volume of water stored in reservoirs would also increase to mitigate seasonal shortages due to rainfall variability and to meet irrigation water needs. By some estimates up to half of the stored water is lost to evaporation, thereby exacerbating the water scarcity problem. Recently, there is an upsurge in the use of self-assembling floating covers to suppress evaporation, yet the design and implementation remain largely empirical. We report a systematic experimental evaluation of different cover types and external drivers (radiation, wind, wind plus radiation) on evaporation suppression and energy balance of a 1.4 m2 basin placed in a wind-tunnel. Surprisingly, evaporation suppression by black and white floating covers (balls and plates) were similar despite significantly different energy balance regimes over the cover surfaces. Moreover, the evaporation suppression efficiency was a simple function of the uncovered area (square root of the uncovered fraction) with linear relations with the covered area in some cases. The thermally decoupled floating covers offer an efficient solution to the evaporation suppression with limited influence of the surface energy balance (water temperature for black and white covers was similar and remained nearly constant). The results will be linked with a predictive evaporation-energy balance model and issues of spatial scales and long exposure times will be studied.

Impurity seeding for suppression of the near scrape-off layer heat flux feature in tokamak limited plasmas

NASA Astrophysics Data System (ADS)

Nespoli, F.; Labit, B.; Furno, I.; Theiler, C.; Sheikh, U. A.; Tsui, C. K.; Boedo, J. A.; TCV Team

2018-05-01

In inboard-limited plasmas, foreseen to be used in future fusion reactor start-up and ramp down phases, the Scrape-Off Layer (SOL) exhibits two regions: the "near" and "far" SOL. The steep radial gradient of the parallel heat flux associated with the near SOL can result in excessive thermal loads onto the solid surfaces, damaging them and/or limiting the operational space of a fusion reactor. In this article, leveraging the results presented in the study by F. Nespoli et al. [Nucl. Fusion 57, 126029 (2017)], we propose a technique for the mitigation and suppression of the near SOL heat flux feature by impurity seeding. The first successful experimental results from the TCV tokamak are presented and discussed.

Seebeck and figure of merit enhancement in nanostructured antimony telluride by antisite defect suppression through sulfur doping.

PubMed

Mehta, Rutvik J; Zhang, Yanliang; Zhu, Hong; Parker, David S; Belley, Matthew; Singh, David J; Ramprasad, Ramamurthy; Borca-Tasciuc, Theodorian; Ramanath, Ganpati

2012-09-12

Antimony telluride has a low thermoelectric figure of merit (ZT < ∼0.3) because of a low Seebeck coefficient α arising from high degenerate hole concentrations generated by antimony antisite defects. Here, we mitigate this key problem by suppressing antisite defect formation using subatomic percent sulfur doping. The resultant 10-25% higher α in bulk nanocrystalline antimony telluride leads to ZT ∼ 0.95 at 423 K, which is superior to the best non-nanostructured antimony telluride alloys. Density functional theory calculations indicate that sulfur increases the antisite formation activation energy and presage further improvements leading to ZT ∼ 2 through optimized doping. Our findings are promising for designing novel thermoelectric materials for refrigeration, waste heat recovery, and solar thermal applications.

A bi-axial active boring tool for chatter mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Redmond, J.M.; Barney, P.S.

This paper summarizes results of metal cutting tests using an actively damped boring bar to suppress regenerative chatter. PZT stack actuators were integrated into a commercially available two-inch diameter boring bar to suppress bending vibrations. Since the modified tool requires no specialized mounting hardware, it can be readily mounted on a variety of machines. A cutting test using the prototype bar to remove metal from a hardened steel workpiece verifies that the authors actively damped tool yields significant vibration reduction and improved surface finish as compared to the open-loop case. In addition, the overall performance of the prototype bar ismore » compared to that of an unmodified bar of pristine geometry, revealing that a significant enlargement of the stable machining envelope is obtained through application of feedback control.« less

Skin effect mitigation in laser processed multi-walled carbon nanotube/copper conductors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keramatnejad, K.; Zhou, Y. S.; Gao, Y.

2015-10-21

In this study, laser-processed multi-walled carbon nanotube (MWCNT)/Cu conductors are introduced as potential passive components to mitigate the skin effect of Cu at high frequencies (0–10 MHz). Suppressed skin effect is observed in the MWCNT/Cu conductors compared to primitive Cu. At an AC frequency of 10 MHz, a maximum AC resistance reduction of 94% was observed in a MWCNT/Cu conductor after being irradiated at a laser power density of 189 W/cm{sup 2}. The reduced skin effect in the MWCNT/Cu conductors is ascribed to the presence of MWCNT channels which are insensitive to AC frequencies. The laser irradiation process is observed to playmore » a crucial role in reducing contact resistance at the MWCNT-Cu interfaces, removing impurities in MWCNTs, and densifying MWCNT films.« less

Mitigation of methane emission from an old unlined landfill in Klintholm, Denmark using a passive biocover system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scheutz, Charlotte; Pedersen, Rasmus Broe; Petersen, Per Haugsted

Highlights: • An innovative biocover system was constructed on a landfill cell to mitigate the methane emission. • The biocover system had a mitigation efficiently of typically 80%. • The system also worked efficiently at ambient temperatures below freezing. • A whole landfill emission measurement tool was required to document the biocover system efficiency. - Abstract: Methane generated at landfills contributes to global warming and can be mitigated by biocover systems relying on microbial methane oxidation. As part of a closure plan for an old unlined landfill without any gas management measures, an innovative biocover system was established. The systemmore » was designed based on a conceptual model of the gas emission patterns established through an initial baseline study. The study included construction of gas collection trenches along the slopes of the landfill where the majority of the methane emissions occurred. Local compost materials were tested as to their usefulness as bioactive methane oxidizing material and a suitable compost mixture was selected. Whole site methane emission quantifications based on combined tracer release and downwind measurements in combination with several local experimental activities (gas composition within biocover layers, flux chamber based emission measurements and logging of compost temperatures) proved that the biocover system had an average mitigation efficiency of approximately 80%. The study showed that the system also had a high efficiency during winter periods with temperatures below freezing. An economic analysis indicated that the mitigation costs of the biocover system were competitive to other existing greenhouse gas mitigation options.« less

Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responses

PubMed Central

Tsai, Tsung-Hsien; Chuang, Lu-Te; Lien, Tsung-Jung; Liing, Yau-Rong; Chen, Wei-Yu

2013-01-01

Abstract Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes–induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes–stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes–induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes–induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes–induced inflammation. PMID:23514231

48 CFR 209.571-4 - Mitigation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Mitigation. 209.571-4... of Interest 209.571-4 Mitigation. (a) Mitigation is any action taken to minimize an organizational conflict of interest. Mitigation may require Government action, contractor action, or a combination of both...

48 CFR 209.571-4 - Mitigation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Mitigation. 209.571-4... of Interest 209.571-4 Mitigation. (a) Mitigation is any action taken to minimize an organizational conflict of interest. Mitigation may require Government action, contractor action, or a combination of both...

48 CFR 209.571-4 - Mitigation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Mitigation. 209.571-4... of Interest 209.571-4 Mitigation. (a) Mitigation is any action taken to minimize an organizational conflict of interest. Mitigation may require Government action, contractor action, or a combination of both...

48 CFR 209.571-4 - Mitigation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Mitigation. 209.571-4... of Interest 209.571-4 Mitigation. (a) Mitigation is any action taken to minimize an organizational conflict of interest. Mitigation may require Government action, contractor action, or a combination of both...

Progress Toward In Vivo Use of siRNAs-II

PubMed Central

Rettig, Garrett R; Behlke, Mark A

2012-01-01

RNA interference (RNAi) has been extensively employed for in vivo research since its use was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it is now routinely possible to obtain reagents that suppress expression of any gene desired. At the same time, increased understanding of the molecular basis of unwanted side effects has led to the development of chemical modification strategies that mitigate these concerns. Delivery remains the single greatest hurdle to widespread adoption of in vivo RNAi methods. However, exciting advances have been made and new delivery systems under development may help to overcome these barriers. This review discusses advances in RNAi biochemistry and biology that impact in vivo use and provides an overview of select publications that demonstrate interesting applications of these principles. Emphasis is placed on work with synthetic, small interfering RNAs (siRNAs) published since the first installment of this review which appeared in 2006. PMID:22186795

Controlling the quantum dynamics of a mesoscopic spin bath in diamond

PubMed Central

de Lange, Gijs; van der Sar, Toeno; Blok, Machiel; Wang, Zhi-Hui; Dobrovitski, Viatcheslav; Hanson, Ronald

2012-01-01

Understanding and mitigating decoherence is a key challenge for quantum science and technology. The main source of decoherence for solid-state spin systems is the uncontrolled spin bath environment. Here, we demonstrate quantum control of a mesoscopic spin bath in diamond at room temperature that is composed of electron spins of substitutional nitrogen impurities. The resulting spin bath dynamics are probed using a single nitrogen-vacancy (NV) centre electron spin as a magnetic field sensor. We exploit the spin bath control to dynamically suppress dephasing of the NV spin by the spin bath. Furthermore, by combining spin bath control with dynamical decoupling, we directly measure the coherence and temporal correlations of different groups of bath spins. These results uncover a new arena for fundamental studies on decoherence and enable novel avenues for spin-based magnetometry and quantum information processing. PMID:22536480

Radiation Protection Using Single-Wall Carbon Nanotube Derivatives

NASA Technical Reports Server (NTRS)

Tour, James M.; Lu, Meng; Lucente-Schultz, Rebecca; Leonard, Ashley; Doyle, Condell Dewayne; Kosynkin, Dimitry V.; Price, Brandi Katherine

2011-01-01

This invention is a means of radiation protection, or cellular oxidative stress mitigation, via a sequence of quenching radical species using nano-engineered scaffolds, specifically single-wall carbon nanotubes (SWNTs) and their derivatives. The material can be used as a means of radiation protection by reducing the number of free radicals within, or nearby, organelles, cells, tissue, organs, or living organisms, thereby reducing the risk of damage to DNA and other cellular components (i.e., RNA, mitochondria, membranes, etc.) that can lead to chronic and/or acute pathologies, including but not limited to cancer, cardiovascular disease, immuno-suppression, and disorders of the central nervous system. In addition, this innovation could be used as a prophylactic or antidote for accidental radiation exposure, during high-altitude or space travel where exposure to radiation is anticipated, or to protect from exposure from deliberate terrorist or wartime use of radiation- containing weapons.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Chenyang; Niu, Liangliang; Chen, Nanjun

A grand challenge in material science is to understand the correlation between intrinsic properties and defect dynamics. Radiation tolerant materials are in great demand for safe operation and advancement of nuclear and aerospace systems. Unlike traditional approaches that rely on microstructural and nanoscale features to mitigate radiation damage, this study demonstrates enhancement of radiation tolerance with the suppression of void formation by two orders magnitude at elevated temperatures in equiatomic single-phase concentrated solid solution alloys, and more importantly, reveals its controlling mechanism through a detailed analysis of the depth distribution of defect clusters and an atomistic computer simulation. The enhancedmore » swelling resistance is attributed to the tailored interstitial defect cluster motion in the alloys from a long-range one-dimensional mode to a short-range three-dimensional mode, which leads to enhanced point defect recombination. Finally, the results suggest design criteria for next generation radiation tolerant structural alloys.« less

DNA Protection Protein, a Novel Mechanism of Radiation Tolerance: Lessons from Tardigrades

PubMed Central

Hashimoto, Takuma; Kunieda, Takekazu

2017-01-01

Genomic DNA stores all genetic information and is indispensable for maintenance of normal cellular activity and propagation. Radiation causes severe DNA lesions, including double-strand breaks, and leads to genome instability and even lethality. Regardless of the toxicity of radiation, some organisms exhibit extraordinary tolerance against radiation. These organisms are supposed to possess special mechanisms to mitigate radiation-induced DNA damages. Extensive study using radiotolerant bacteria suggested that effective protection of proteins and enhanced DNA repair system play important roles in tolerability against high-dose radiation. Recent studies using an extremotolerant animal, the tardigrade, provides new evidence that a tardigrade-unique DNA-associating protein, termed Dsup, suppresses the occurrence of DNA breaks by radiation in human-cultured cells. In this review, we provide a brief summary of the current knowledge on extremely radiotolerant animals, and present novel insights from the tardigrade research, which expand our understanding on molecular mechanism of exceptional radio-tolerability. PMID:28617314

Enhancing radiation tolerance by controlling defect mobility and migration pathways in multicomponent single-phase alloys

NASA Astrophysics Data System (ADS)

Lu, Chenyang; Niu, Liangliang; Chen, Nanjun; Jin, Ke; Yang, Taini; Xiu, Pengyuan; Zhang, Yanwen; Gao, Fei; Bei, Hongbin; Shi, Shi; He, Mo-Rigen; Robertson, Ian M.; Weber, William J.; Wang, Lumin

2016-12-01

A grand challenge in material science is to understand the correlation between intrinsic properties and defect dynamics. Radiation tolerant materials are in great demand for safe operation and advancement of nuclear and aerospace systems. Unlike traditional approaches that rely on microstructural and nanoscale features to mitigate radiation damage, this study demonstrates enhancement of radiation tolerance with the suppression of void formation by two orders magnitude at elevated temperatures in equiatomic single-phase concentrated solid solution alloys, and more importantly, reveals its controlling mechanism through a detailed analysis of the depth distribution of defect clusters and an atomistic computer simulation. The enhanced swelling resistance is attributed to the tailored interstitial defect cluster motion in the alloys from a long-range one-dimensional mode to a short-range three-dimensional mode, which leads to enhanced point defect recombination. The results suggest design criteria for next generation radiation tolerant structural alloys.

Biological souring and mitigation in oil reservoirs.

PubMed

Gieg, Lisa M; Jack, Tom R; Foght, Julia M

2011-10-01

Souring in oil field systems is most commonly due to the action of sulfate-reducing prokaryotes, a diverse group of anaerobic microorganisms that respire sulfate and produce sulfide (the key souring agent) while oxidizing diverse electron donors. Such biological sulfide production is a detrimental, widespread phenomenon in the petroleum industry, occurring within oil reservoirs or in topside processing facilities, under low- and high-temperature conditions, and in onshore or offshore operations. Sulfate reducers can exist either indigenously in deep subsurface reservoirs or can be "inoculated" into a reservoir system during oil field development (e.g., via drilling operations) or during the oil production phase. In the latter, souring most commonly occurs during water flooding, a secondary recovery strategy wherein water is injected to re-pressurize the reservoir and sweep the oil towards production wells to extend the production life of an oil field. The water source and type of production operation can provide multiple components such as sulfate, labile carbon sources, and sulfate-reducing communities that influence whether oil field souring occurs. Souring can be controlled by biocides, which can non-specifically suppress microbial populations, and by the addition of nitrate (and/or nitrite) that directly impacts the sulfate-reducing population by numerous competitive or inhibitory mechanisms. In this review, we report on the diversity of sulfate reducers associated with oil reservoirs, approaches for determining their presence and effects, the factors that control souring, and the approaches (along with the current understanding of their underlying mechanisms) that may be used to successfully mitigate souring in low-temperature and high-temperature oil field operations.

Cognitive software defined radar: waveform design for clutter and interference suppression

NASA Astrophysics Data System (ADS)

Kirk, Benjamin H.; Owen, Jonathan W.; Narayanan, Ram M.; Blunt, Shannon D.; Martone, Anthony F.; Sherbondy, Kelly D.

2017-05-01

Clutter and radio frequency interference (RFI) are prevalent issues in the field of radar and are specifically of interest to of cognitive radar. Here, methods for applying and testing the utility of cognitive radar for clutter and RFI mitigation are explored. Using the adaptable transmit capability, environmental database, and general "awareness" of a cognitive radar system (i.e. spectrum sensing, geographical location, etc.), a matched waveform is synthesized that improves the signal-to-clutter ratio (SCR), assuming at least an estimate of the target response and the environmental clutter response are known a prior i. RFI may also be mitigated by sensing the RF spectrum and adapting the transmit center frequency and bandwidth using methods that optimize bandwidth and signal-to-interference plus noise ratio (SINR) (i.e. the spectrum sensing, multi-objective (SS-MO) algorithm). The improvement is shown by a decrease in the noise floor. The above methods' effectiveness are examined via a test-bed developed around a software defined radio (SDR). Testing and the general use of commercial off the shelf (COTS) devices are desirable for their cost effectiveness, general ease of use, as well as technical and community support, but these devices provide design challenges in order to be effective. The universal software radio peripheral (USRP) X310 SDR is a relatively cheap and portable device that has all the system components of a basic cognitive radar. Design challenges of the SDR include phase coherency between channels, bandwidth limitations, dynamic range, and speed of computation and data communication / recording.

Mitigating Greenhouse Gas and Ammonia Emissions from Swine Manure Management: A System Analysis.

PubMed

Wang, Yue; Dong, Hongmin; Zhu, Zhiping; Gerber, Pierre J; Xin, Hongwei; Smith, Pete; Opio, Carolyn; Steinfeld, Henning; Chadwick, Dave

2017-04-18

Gaseous emissions from animal manure are considerable contributor to global ammonia (NH 3 ) and agriculture greenhouse gas (GHG) emissions. Given the demand to promote mitigation of GHGs while fostering sustainable development of the Paris Agreement, an improvement of management systems is urgently needed to help mitigate climate change and to improve atmospheric air quality. This study presents a meta-analysis and an integrated assessment of gaseous emissions and mitigation potentials for NH 3 , methane (CH 4 ), and nitrous oxide (N 2 O) (direct and indirect) losses from four typical swine manure management systems (MMSs). The resultant emission factors and mitigation efficiencies allow GHG and NH 3 emissions to be estimated, as well as mitigation potentials for different stages of swine operation. In particular, changing swine manure management from liquid systems to solid-liquid separation systems, coupled with mitigation measures, could simultaneously reduce GHG emissions by 65% and NH 3 emissions by 78%. The resultant potential reduction in GHG emissions from China's pig production alone is greater than the entire GHG emissions from agricultural sector of France, Australia, or Germany, while the reduction in NH 3 emissions is equivalent to 40% of the total NH 3 emissions from the European Union. Thus, improved swine manure management could have a significant impact on global environment issues.

Interference Mitigation Effects on Synthetic Aperture Radar Coherent Data Products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Musgrove, Cameron

For synthetic aperture radars radio frequency interference from sources external to the radar system and techniques to mitigate the interference can degrade the quality of the image products. Usually the radar system designer will try to balance the amount of mitigation for an acceptable amount of interference to optimize the image quality. This dissertation examines the effect of interference mitigation upon coherent data products of fine resolution, high frequency synthetic aperture radars using stretch processing. Novel interference mitigation techniques are introduced that operate on single or multiple apertures of data that increase average coherence compared to existing techniques. New metricsmore » are applied to evaluate multiple mitigation techniques for image quality and average coherence. The underlying mechanism for interference mitigation techniques that affect coherence is revealed.« less

Exploring Complex Systems Aspects of Blackout Risk and Mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newman, David E; Carreras, Benjamin A; Lynch, Vickie E

2011-01-01

Electric power transmission systems are a key infrastructure, and blackouts of these systems have major consequences for the economy and national security. Analyses of blackout data suggest that blackout size distributions have a power law form over much of their range. This result is an indication that blackouts behave as a complex dynamical system. We use a simulation of an upgrading power transmission system to investigate how these complex system dynamics impact the assessment and mitigation of blackout risk. The mitigation of failures in complex systems needs to be approached with care. The mitigation efforts can move the system tomore » a new dynamic equilibrium while remaining near criticality and preserving the power law region. Thus, while the absolute frequency of blackouts of all sizes may be reduced, the underlying forces can still cause the relative frequency of large blackouts to small blackouts to remain the same. Moreover, in some cases, efforts to mitigate small blackouts can even increase the frequency of large blackouts. This result occurs because the large and small blackouts are not mutually independent, but are strongly coupled by the complex dynamics.« less

Evaporation suppression from water reservoirs using floating covers: Lab scale observations and model predictions

NASA Astrophysics Data System (ADS)

Or, D.; Lehmann, P.; Aminzadeh, M.; Sommer, M.; Wey, H.; Wunderli, H.; Breitenstein, D.

2016-12-01

The competition over dwindling fresh water resources is expected to intensify with projected increase in human population in arid regions, expansion of irrigated land and changes in climate and drought patterns. The volume of water stored in reservoirs would also increase to mitigate seasonal shortages due to rainfall variability and to meet irrigation water needs. By some estimates up to half of the stored water is lost to evaporation thereby exacerbating the water scarcity problem. Recently, there is an upsurge in the use of self-assembling floating covers to suppress evaporation, yet the design, and implementation remain largely empirical. Studies have shown that evaporation suppression is highly nonlinear, as also known from a century of research on gas exchange from plant leaves (that often evaporate as free water surfaces through stomata that are only 1% of leaf area). We report a systematic evaluation of different cover types and external drivers (radiation, wind, wind+radiation) on evaporation suppression and energy balance of a 1.4 m2 basin placed in a wind-tunnel. Surprisingly, evaporation suppression by black and white floating covers (balls and plates) were similar despite significantly different energy balance regimes over the cover surfaces. Moreover, the evaporation suppression efficiency was a simple function of the uncovered area (square root of the uncovered fraction) with linear relations with the covered area in some cases. The thermally decoupled floating covers offer an efficient solution to the evaporation suppression with limited influence of the surface energy balance (water temperature for black and white covers was similar and remained nearly constant). The results will be linked with a predictive evaporation-energy balance model and issues of spatial scales and long exposure times will be studied.

GNSS Space-Time Interference Mitigation and Attitude Determination in the Presence of Interference Signals

PubMed Central

Daneshmand, Saeed; Jahromi, Ali Jafarnia; Broumandan, Ali; Lachapelle, Gérard

2015-01-01

The use of Space-Time Processing (STP) in Global Navigation Satellite System (GNSS) applications is gaining significant attention due to its effectiveness for both narrowband and wideband interference suppression. However, the resulting distortion and bias on the cross correlation functions due to space-time filtering is a major limitation of this technique. Employing the steering vector of the GNSS signals in the filter structure can significantly reduce the distortion on cross correlation functions and lead to more accurate pseudorange measurements. This paper proposes a two-stage interference mitigation approach in which the first stage estimates an interference-free subspace before the acquisition and tracking phases and projects all received signals into this subspace. The next stage estimates array attitude parameters based on detecting and employing GNSS signals that are less distorted due to the projection process. Attitude parameters enable the receiver to estimate the steering vector of each satellite signal and use it in the novel distortionless STP filter to significantly reduce distortion and maximize Signal-to-Noise Ratio (SNR). GPS signals were collected using a six-element antenna array under open sky conditions to first calibrate the antenna array. Simulated interfering signals were then added to the digitized samples in software to verify the applicability of the proposed receiver structure and assess its performance for several interference scenarios. PMID:26016909

GNSS space-time interference mitigation and attitude determination in the presence of interference signals.

PubMed

Daneshmand, Saeed; Jahromi, Ali Jafarnia; Broumandan, Ali; Lachapelle, Gérard

2015-05-26

The use of Space-Time Processing (STP) in Global Navigation Satellite System (GNSS) applications is gaining significant attention due to its effectiveness for both narrowband and wideband interference suppression. However, the resulting distortion and bias on the cross correlation functions due to space-time filtering is a major limitation of this technique. Employing the steering vector of the GNSS signals in the filter structure can significantly reduce the distortion on cross correlation functions and lead to more accurate pseudorange measurements. This paper proposes a two-stage interference mitigation approach in which the first stage estimates an interference-free subspace before the acquisition and tracking phases and projects all received signals into this subspace. The next stage estimates array attitude parameters based on detecting and employing GNSS signals that are less distorted due to the projection process. Attitude parameters enable the receiver to estimate the steering vector of each satellite signal and use it in the novel distortionless STP filter to significantly reduce distortion and maximize Signal-to-Noise Ratio (SNR). GPS signals were collected using a six-element antenna array under open sky conditions to first calibrate the antenna array. Simulated interfering signals were then added to the digitized samples in software to verify the applicability of the proposed receiver structure and assess its performance for several interference scenarios.

Destructive Interactions Between Mitigation Strategies and the Causes of Unexpected Failures in Natural Hazard Mitigation Systems

NASA Astrophysics Data System (ADS)

Day, S. J.; Fearnley, C. J.

2013-12-01

Large investments in the mitigation of natural hazards, using a variety of technology-based mitigation strategies, have proven to be surprisingly ineffective in some recent natural disasters. These failures reveal a need for a systematic classification of mitigation strategies; an understanding of the scientific uncertainties that affect the effectiveness of such strategies; and an understanding of how the different types of strategy within an overall mitigation system interact destructively to reduce the effectiveness of the overall mitigation system. We classify mitigation strategies into permanent, responsive and anticipatory. Permanent mitigation strategies such as flood and tsunami defenses or land use restrictions, are both costly and 'brittle': when they malfunction they can increase mortality. Such strategies critically depend on the accuracy of the estimates of expected hazard intensity in the hazard assessments that underpin their design. Responsive mitigation strategies such as tsunami and lahar warning systems rely on capacities to detect and quantify the hazard source events and to transmit warnings fast enough to enable at risk populations to decide and act effectively. Self-warning and voluntary evacuation is also usually a responsive mitigation strategy. Uncertainty in the nature and magnitude of the detected hazard source event is often the key scientific obstacle to responsive mitigation; public understanding of both the hazard and the warnings, to enable decision making, can also be a critical obstacle. Anticipatory mitigation strategies use interpretation of precursors to hazard source events and are used widely in mitigation of volcanic hazards. Their critical limitations are due to uncertainties in time, space and magnitude relationships between precursors and hazard events. Examples of destructive interaction between different mitigation strategies are provided by the Tohoku 2011 earthquake and tsunami; recent earthquakes that have impacted population centers with poor enforcement of building codes, unrealistic expectations of warning systems or failures to understand local seismic damage mechanisms; and the interaction of land use restriction strategies and responsive warning strategies around lahar-prone volcanoes. A more complete understanding of the interactions between these different types of mitigation strategy, especially the consequences for the expectations and behaviors of the populations at risk, requires models of decision-making under high levels of both uncertainty and danger. The Observation-Orientation-Decision-Action (OODA) loop model (Boyd, 1987) may be a particularly useful model. It emphasizes the importance of 'orientation' (the interpretation of observations and assessment of their significance for the observer and decision-maker), the feedback between decisions and subsequent observations and orientations, and the importance of developing mitigation strategies that are flexible and so able to respond to the occurrence of the unexpected. REFERENCE: Boyd, J.R. A Discourse on Winning and Losing [http://dnipogo.org/john-r-boyd/

Experimental evaluation and analysis of methane fire and explosion mitigation using isolation valves integrated with a vent system.

PubMed

Ajrash, Mohammed J; Zanganeh, Jafar; Moghtaderi, Behdad

2017-10-05

There has been a surge of interest from the extractive industries in the application of mechanical means to the mitigation of flame deflagration. To verify the implementation and performance of passive and active mitigation protection, a comprehensive experimental investigation has been conducted on a large scale detonation tube, 30m long and 0.5m in diameter, with two mitigation valves (passive and active) and a burst panel venting system. The valves were used alternately to mitigate the flame deflagration of methane in concentrations ranging from 1.25% to 7.5%. The experimental work revealed that locating the passive mitigation valve at 22m distance from the ignition source mitigates the flame by fully isolating the tube. However, closing the valve structure in the axial direction generated another pressure wave upstream, which was approximately the same value as for the original pressure wave upstream. In the case of the active mitigation system, the system perfectly isolated upstream from downstream with no further pressure wave generation. When the vent was located at 6.5m from the ignition source, the total pressure was reduced by 0.48bar. Due to the counter flow of the reflected pressure wave the flame was extinguished at 12.5m from the ignition source. Copyright © 2017 Elsevier B.V. All rights reserved.

Leveling the playing field: attention mitigates the effects of intelligence on memory.

PubMed

Markant, Julie; Amso, Dima

2014-05-01

Effective attention and memory skills are fundamental to typical development and essential for achievement during the formal education years. It is critical to identify the specific mechanisms linking efficiency of attentional selection of an item and the quality of its memory retention. The present study capitalized on the spatial cueing paradigm to examine the role of selection via suppression in modulating children and adolescents' memory encoding. By varying a single parameter, the spatial cueing task can elicit either a simple orienting mechanism (i.e., facilitation) or one that involves both target selection and simultaneous suppression of competing information (i.e., IOR). We modified this paradigm to include images of common items in target locations. Participants were not instructed to learn the items and were not told they would be completing a memory test later. Following the cueing task, we imposed a 7-min delay and then asked participants to complete a recognition memory test. Results indicated that selection via suppression promoted recognition memory among 7-17year-olds. Moreover, individual differences in the extent of suppression during encoding predicted recognition memory accuracy. When basic cueing facilitated orienting to target items during encoding, IQ was the best predictor of recognition memory performance for the attended items. In contrast, engaging suppression (i.e., IOR) during encoding counteracted individual differences in intelligence, effectively improving recognition memory performance among children with lower IQs. This work demonstrates that engaging selection via suppression during learning and encoding improves memory retention and has broad implications for developing effective educational techniques. Copyright © 2014 Elsevier B.V. All rights reserved.

Leveling the playing field: Attention mitigates the effects of intelligence on memory

PubMed Central

Markant, Julie; Amso, Dima

2014-01-01

Effective attention and memory skills are fundamental to typical development and essential for achievement during the formal education years. It is critical to identify the specific mechanisms linking efficiency of attentional selection of an item and the quality of its memory retention. The present study capitalized on the spatial cueing paradigm to examine the role of selection via suppression in modulating children and adolescents’ memory encoding. By varying a single parameter, the spatial cueing task can elicit either a simple orienting mechanism (i.e., facilitation) or one that involves both target selection and simultaneous suppression of competing information (i.e., IOR). We modified this paradigm to include images of common items in target locations. Participants were not instructed to learn the items and were not told they would be completing a memory test later. Following the cueing task, we imposed a seven-minute delay and then asked participants to complete a recognition memory test. Results indicated that selection via suppression promoted recognition memory among 7-17 year-olds. Moreover, individual differences in the extent of suppression during encoding predicted recognition memory accuracy. When basic cueing facilitated orienting to target items during encoding, IQ was the best predictor of recognition memory performance for the attended items. In contrast, engaging suppression (i.e, IOR) during encoding counteracted individual differences in intelligence, effectively improving recognition memory performance among children with lower IQs. This work demonstrates that engaging selection via suppression during learning and encoding improves memory retention and has broad implications for developing effective educational techniques. PMID:24549142

Suppression of Alfvénic modes with off-axis NBI

NASA Astrophysics Data System (ADS)

Fredrickson, Eric; Bell, R.; Diallo, A.; Leblanc, B.; Podesta, M.; Levinton, F.; Yuh, H.; Liu, D.

2016-10-01

GAE are seen on NSTX-U in the frequency range from 1 to 3 MHz with injection of the more perpendicular, NSTX neutral beam sources. A new result is that injection of any of the new, more tangential, neutral beam sources with tangency radii larger than the magnetic axis suppress this GAE activity. Simulations of beam deposition and slowing down with the TRANSP code indicate that these new sources deposit fast ions with 0.9

75 FR 8431 - Carbon Dioxide Fire Suppression Systems on Commercial Vessels

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... Fire Suppression Systems on Commercial Vessels; Proposed Rule #0;#0;Federal Register / Vol. 75 , No. 36... 1625-AB44 Carbon Dioxide Fire Suppression Systems on Commercial Vessels AGENCY: Coast Guard, DHS... for fire suppression systems on several classes of commercial vessels. The amendments would clarify...

Women in war: operational issues of menstruation and unintended pregnancy.

PubMed

Christopher, Leslie A; Miller, Leslie

2007-01-01

With rapid and frequent deployments around the world, the current high level of military operations demands combat readiness of every military member. In the U.S. Armed Forces, women represent 15% of active duty troops and 17% of reserve and Guard troops and are a critical component for mission accomplishment. The operational issues of menstruation and unintended pregnancy, unique to this population, can decrease a female member's military readiness and affect her ability to deploy. Strategies to mitigate and even eliminate these concerns include the optional use of hormonal medications to induce reversible menstrual cycle suppression. These medications, traditionally indicated for contraception, should be considered essential for female troops during training and deployment. This article, tailored specifically for military women, provides valuable information regarding the risks and benefits, as well as the various options available for menstrual cycle suppression.

Fluorinated Electrolytes for Li-S Battery: Suppressing the Self-Discharge with an Electrolyte Containing Fluoroether Solvent

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azimi, N.; Xue, Z.; Rago, N. D.

The fluorinated electrolyte containing a fluoroether 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (TTE) was investigated as a new electrolyte for lithium-sulfur (Li-S) batteries. The low solubility of lithium polysulfides (LiPS) in the fluorinated electrolyte reduced the parasitic reactions with Li anode and mitigated the self-discharge by limiting their diffusion from the cathode to the anode. The use of fluorinated ether as a co-solvent and LiNO3 as an additive in the electrolyte shows synergetic effect in suppressing the self-discharge of Li-S battery due to the formation of the solid electrolyte interphase (SEI) on both sulfur cathode and the lithium anode. The Li-S cell with themore » fluorinated electrolyte showed prolonged shelf life at fully charged state.« less

12 CFR 222.90 - Duties regarding the detection, prevention, and mitigation of identity theft.

Code of Federal Regulations, 2011 CFR

2011-01-01

... mitigation of identity theft. 222.90 Section 222.90 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Identity Theft Red Flags § 222.90 Duties regarding the detection, prevention, and mitigation of identity theft. (a) Scope...

12 CFR 222.90 - Duties regarding the detection, prevention, and mitigation of identity theft.

Code of Federal Regulations, 2012 CFR

2012-01-01

... mitigation of identity theft. 222.90 Section 222.90 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Identity Theft Red Flags § 222.90 Duties regarding the detection, prevention, and mitigation of identity theft. (a) Scope...

Calcium-based multi-element chemistry for grid-scale electrochemical energy storage

NASA Astrophysics Data System (ADS)

Ouchi, Takanari; Kim, Hojong; Spatocco, Brian L.; Sadoway, Donald R.

2016-03-01

Calcium is an attractive material for the negative electrode in a rechargeable battery due to its low electronegativity (high cell voltage), double valence, earth abundance and low cost; however, the use of calcium has historically eluded researchers due to its high melting temperature, high reactivity and unfavorably high solubility in molten salts. Here we demonstrate a long-cycle-life calcium-metal-based rechargeable battery for grid-scale energy storage. By deploying a multi-cation binary electrolyte in concert with an alloyed negative electrode, calcium solubility in the electrolyte is suppressed and operating temperature is reduced. These chemical mitigation strategies also engage another element in energy storage reactions resulting in a multi-element battery. These initial results demonstrate how the synergistic effects of deploying multiple chemical mitigation strategies coupled with the relaxation of the requirement of a single itinerant ion can unlock calcium-based chemistries and produce a battery with enhanced performance.

Calcium-based multi-element chemistry for grid-scale electrochemical energy storage

PubMed Central

Ouchi, Takanari; Kim, Hojong; Spatocco, Brian L.; Sadoway, Donald R.

2016-01-01

Calcium is an attractive material for the negative electrode in a rechargeable battery due to its low electronegativity (high cell voltage), double valence, earth abundance and low cost; however, the use of calcium has historically eluded researchers due to its high melting temperature, high reactivity and unfavorably high solubility in molten salts. Here we demonstrate a long-cycle-life calcium-metal-based rechargeable battery for grid-scale energy storage. By deploying a multi-cation binary electrolyte in concert with an alloyed negative electrode, calcium solubility in the electrolyte is suppressed and operating temperature is reduced. These chemical mitigation strategies also engage another element in energy storage reactions resulting in a multi-element battery. These initial results demonstrate how the synergistic effects of deploying multiple chemical mitigation strategies coupled with the relaxation of the requirement of a single itinerant ion can unlock calcium-based chemistries and produce a battery with enhanced performance. PMID:27001915

Calcium-based multi-element chemistry for grid-scale electrochemical energy storage.

PubMed

Ouchi, Takanari; Kim, Hojong; Spatocco, Brian L; Sadoway, Donald R

2016-03-22

Calcium is an attractive material for the negative electrode in a rechargeable battery due to its low electronegativity (high cell voltage), double valence, earth abundance and low cost; however, the use of calcium has historically eluded researchers due to its high melting temperature, high reactivity and unfavorably high solubility in molten salts. Here we demonstrate a long-cycle-life calcium-metal-based rechargeable battery for grid-scale energy storage. By deploying a multi-cation binary electrolyte in concert with an alloyed negative electrode, calcium solubility in the electrolyte is suppressed and operating temperature is reduced. These chemical mitigation strategies also engage another element in energy storage reactions resulting in a multi-element battery. These initial results demonstrate how the synergistic effects of deploying multiple chemical mitigation strategies coupled with the relaxation of the requirement of a single itinerant ion can unlock calcium-based chemistries and produce a battery with enhanced performance.

ATWS analysis for Browns Ferry Nuclear Plant Unit 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dallman, R.J.; Jouse, W.C.

1985-01-01

Analyses of postulated Anticipated Transients Without Scram (ATWS) were performed at the Idaho National Engineering Laboratory (INEL). The Browns Ferry Nuclear Plant Unit 1 (BFNP1) was selected as the subject of this work because of the cooperation of the Tennessee Valley Authority (TVA). The work is part of the Severe Accident Sequence Analysis (SASA) Program of the US Nuclear Regulatory Commission (NRC). A Main Steamline Isolation Valve (MSIV) closure served as the transient initiator for these analyses, which proceeded a complete failure to scram. Results from the analyses indicate that operator mitigative actions are required to prevent overpressurization of themore » primary containment. Uncertainties remain concerning the effectiveness of key mitigative actions. The effectiveness of level control as a power reduction procedure is limited. Power level resulting from level control only reduce the Pressure Suppression Pool (PSP) heatup rate from 6 to 4F/min.« less

VEGF ameliorates the ataxic phenotype in spinocerebellar ataxia type 1 (SCA1) mice

PubMed Central

Cvetanovic, Marija; Patel, Jay; Marti, Hugo H; Kini, Ameet R; Opal, Puneet

2012-01-01

SCA1 is an adult-onset, dominantly inherited neurodegenerative disease caused by expansion of a glutamine repeat tract in ATXN1. Although the precise function of ATXN1 remains elusive, it appears to play a role in transcriptional repression. We find that mutant ATXN1 suppresses transcription of the neurotrophic and angiogenic factor VEGF. We also show that genetic or pharmacologic replenishment of VEGF mitigates SCA1 pathogenesis, suggesting a novel therapeutic strategy for this incurable disease. PMID:22001907

Electromagnetically induced transparency with noisy lasers

NASA Astrophysics Data System (ADS)

Xiao, Yanhong; Wang, Tun; Baryakhtar, Maria; van Camp, Mackenzie; Crescimanno, Michael; Hohensee, Michael; Jiang, Liang; Phillips, David F.; Lukin, Mikhail D.; Yelin, Susanne F.; Walsworth, Ronald L.

2009-10-01

We demonstrate and characterize two coherent phenomena that can mitigate the effects of laser phase noise for electromagnetically induced transparency (EIT): a laser-power-broadening-resistant resonance in the transmitted intensity cross correlation between EIT optical fields, and a resonant suppression of the conversion of laser phase noise to intensity noise when one-photon noise dominates over two-photon-detuning noise. Our experimental observations are in good agreement with both an intuitive physical picture and numerical calculations. The results have wide-ranging applications to spectroscopy, atomic clocks, and magnetometers.

Overview of Risk Mitigation for Safety-Critical Computer-Based Systems

NASA Technical Reports Server (NTRS)

Torres-Pomales, Wilfredo

2015-01-01

This report presents a high-level overview of a general strategy to mitigate the risks from threats to safety-critical computer-based systems. In this context, a safety threat is a process or phenomenon that can cause operational safety hazards in the form of computational system failures. This report is intended to provide insight into the safety-risk mitigation problem and the characteristics of potential solutions. The limitations of the general risk mitigation strategy are discussed and some options to overcome these limitations are provided. This work is part of an ongoing effort to enable well-founded assurance of safety-related properties of complex safety-critical computer-based aircraft systems by developing an effective capability to model and reason about the safety implications of system requirements and design.

MISSIONS: The Mobile-Based Disaster Mitigation System in Indonesia

NASA Astrophysics Data System (ADS)

Passarella, Rossi; Putri Raflesia, Sarifah; Lestarini, Dinda; Rifai, Ahmad; Veny, Harumi

2018-04-01

Disaster mitigation is essential to minimize the effects of disasters. Indonesia is one of the disaster prone areas in Asia and the government explores the usage of Information technology (IT) to aid its mitigation efforts. Currently, there are Indonesian websites which hold information regarding the weather monitoring, climate conditions, and geophysics. But, there is no clear indicator of mitigation efforts or things to do during an emergency. Therefore, this research proposed MISSIONS, a disaster mitigation model using geo-fencing technique to detect the location of the users through their mobile devices. MISSIONS uses mobile-based disaster mitigation system as a way to disseminate critical information to victims during emergency when they are in disaster zones using virtual fences. It aims to help the government to reduce the effects of disaster and aid in the mitigation efforts. The implementation result shows that MISSIONS have a high accuracy in detecting user whereabouts.

A Robust State Estimation Framework Considering Measurement Correlations and Imperfect Synchronization

DOE PAGES

Zhao, Junbo; Wang, Shaobu; Mili, Lamine; ...

2018-01-08

Here, this paper develops a robust power system state estimation framework with the consideration of measurement correlations and imperfect synchronization. In the framework, correlations of SCADA and Phasor Measurements (PMUs) are calculated separately through unscented transformation and a Vector Auto-Regression (VAR) model. In particular, PMU measurements during the waiting period of two SCADA measurement scans are buffered to develop the VAR model with robustly estimated parameters using projection statistics approach. The latter takes into account the temporal and spatial correlations of PMU measurements and provides redundant measurements to suppress bad data and mitigate imperfect synchronization. In case where the SCADAmore » and PMU measurements are not time synchronized, either the forecasted PMU measurements or the prior SCADA measurements from the last estimation run are leveraged to restore system observability. Then, a robust generalized maximum-likelihood (GM)-estimator is extended to integrate measurement error correlations and to handle the outliers in the SCADA and PMU measurements. Simulation results that stem from a comprehensive comparison with other alternatives under various conditions demonstrate the benefits of the proposed framework.« less

Screening Effect of Plasma Flow on RMP Penetration in EXTRAP T2R

NASA Astrophysics Data System (ADS)

Frassinetti, Lorenzo; Olofsson, Erik; Brunsell, Per; Menmuir, Sheena; Drake, James

2011-10-01

The penetration of resonant magnetic perturbations (RMP) can be screened by plasma flow and the understanding of this phenomenon is important for ELM mitigation techniques. This work studies the screening effect in EXTRAP T2R. EXTRAP T2R is equipped with a feedback system able to suppress all error fields and to produce one or more external perturbations in a controlled fashion. The EXTRAP T2R feedback system is used to generate a RMP that interacts with the dynamics of its corresponding tearing mode (TM). The level of RMP penetration is quantified by analyzing the RMP effect on the TM amplitude and velocity. To study the screening effect, the flow is changed by applying a second perturbation that is non resonant (non-RMP). This produces the flow reduction without perturbing significantly the other parameters. By modifying the amplitude of the non-RMP, an experimental study of the flow effect on the RMP penetration is performed. Experimental results are compared with the model described in [Fitzpatrick R et al., Phys. Plasmas 8, 4489 (2001)].

A Robust State Estimation Framework Considering Measurement Correlations and Imperfect Synchronization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Junbo; Wang, Shaobu; Mili, Lamine

Here, this paper develops a robust power system state estimation framework with the consideration of measurement correlations and imperfect synchronization. In the framework, correlations of SCADA and Phasor Measurements (PMUs) are calculated separately through unscented transformation and a Vector Auto-Regression (VAR) model. In particular, PMU measurements during the waiting period of two SCADA measurement scans are buffered to develop the VAR model with robustly estimated parameters using projection statistics approach. The latter takes into account the temporal and spatial correlations of PMU measurements and provides redundant measurements to suppress bad data and mitigate imperfect synchronization. In case where the SCADAmore » and PMU measurements are not time synchronized, either the forecasted PMU measurements or the prior SCADA measurements from the last estimation run are leveraged to restore system observability. Then, a robust generalized maximum-likelihood (GM)-estimator is extended to integrate measurement error correlations and to handle the outliers in the SCADA and PMU measurements. Simulation results that stem from a comprehensive comparison with other alternatives under various conditions demonstrate the benefits of the proposed framework.« less

Sideband instability analysis based on a one-dimensional high-gain free electron laser model

DOE PAGES

Tsai, Cheng-Ying; Wu, Juhao; Yang, Chuan; ...

2017-12-18

When an untapered high-gain free electron laser (FEL) reaches saturation, the exponential growth ceases and the radiation power starts to oscillate about an equilibrium. The FEL radiation power or efficiency can be increased by undulator tapering. For a high-gain tapered FEL, although the power is enhanced after the first saturation, it is known that there is a so-called second saturation where the FEL power growth stops even with a tapered undulator system. The sideband instability is one of the primary reasons leading to this second saturation. In this paper, we provide a quantitative analysis on how the gradient of undulatormore » tapering can mitigate the sideband growth. The study is carried out semianalytically and compared with one-dimensional numerical simulations. The physical parameters are taken from Linac Coherent Light Source-like electron bunch and undulator systems. The sideband field gain and the evolution of the radiation spectra for different gradients of undulator tapering are examined. It is found that a strong undulator tapering (~10 % ) provides effective suppression of the sideband instability in the postsaturation regime.« less

Sideband instability analysis based on a one-dimensional high-gain free electron laser model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsai, Cheng-Ying; Wu, Juhao; Yang, Chuan

When an untapered high-gain free electron laser (FEL) reaches saturation, the exponential growth ceases and the radiation power starts to oscillate about an equilibrium. The FEL radiation power or efficiency can be increased by undulator tapering. For a high-gain tapered FEL, although the power is enhanced after the first saturation, it is known that there is a so-called second saturation where the FEL power growth stops even with a tapered undulator system. The sideband instability is one of the primary reasons leading to this second saturation. In this paper, we provide a quantitative analysis on how the gradient of undulatormore » tapering can mitigate the sideband growth. The study is carried out semianalytically and compared with one-dimensional numerical simulations. The physical parameters are taken from Linac Coherent Light Source-like electron bunch and undulator systems. The sideband field gain and the evolution of the radiation spectra for different gradients of undulator tapering are examined. It is found that a strong undulator tapering (~10 % ) provides effective suppression of the sideband instability in the postsaturation regime.« less

AST Launch Vehicle Acoustics

NASA Technical Reports Server (NTRS)

Houston, Janice; Counter, D.; Giacomoni, D.

2015-01-01

The liftoff phase induces acoustic loading over a broad frequency range for a launch vehicle. These external acoustic environments are then used in the prediction of internal vibration responses of the vehicle and components which result in the qualification levels. Thus, predicting these liftoff acoustic (LOA) environments is critical to the design requirements of any launch vehicle. If there is a significant amount of uncertainty in the predictions or if acoustic mitigation options must be implemented, a subscale acoustic test is a feasible pre-launch test option to verify the LOA environments. The NASA Space Launch System (SLS) program initiated the Scale Model Acoustic Test (SMAT) to verify the predicted SLS LOA environments and to determine the acoustic reduction with an above deck water sound suppression system. The SMAT was conducted at Marshall Space Flight Center and the test article included a 5% scale SLS vehicle model, tower and Mobile Launcher. Acoustic and pressure data were measured by approximately 250 instruments. The SMAT liftoff acoustic results are presented, findings are discussed and a comparison is shown to the Ares I Scale Model Acoustic Test (ASMAT) results.

Sideband instability analysis based on a one-dimensional high-gain free electron laser model

NASA Astrophysics Data System (ADS)

Tsai, Cheng-Ying; Wu, Juhao; Yang, Chuan; Yoon, Moohyun; Zhou, Guanqun

2017-12-01

When an untapered high-gain free electron laser (FEL) reaches saturation, the exponential growth ceases and the radiation power starts to oscillate about an equilibrium. The FEL radiation power or efficiency can be increased by undulator tapering. For a high-gain tapered FEL, although the power is enhanced after the first saturation, it is known that there is a so-called second saturation where the FEL power growth stops even with a tapered undulator system. The sideband instability is one of the primary reasons leading to this second saturation. In this paper, we provide a quantitative analysis on how the gradient of undulator tapering can mitigate the sideband growth. The study is carried out semianalytically and compared with one-dimensional numerical simulations. The physical parameters are taken from Linac Coherent Light Source-like electron bunch and undulator systems. The sideband field gain and the evolution of the radiation spectra for different gradients of undulator tapering are examined. It is found that a strong undulator tapering (˜10 %) provides effective suppression of the sideband instability in the postsaturation regime.

A Heuristic Decision Making Model to Mitigate Adverse Consequences in a Network Centric Warfare/Sense and Respond System

DTIC Science & Technology

2005-05-01

made. 4. Do military decision makers identify / analyze adverse consequences presently? Few do based on this research and most don’t do it effectively ...A HEURISTIC DECISION MAKING MODEL TO MITIGATE ADVERSE CONSEQUENCES IN A NETWORK CENTRIC WARFARE / SENSE AND RESPOND SYSTEM...ENS/05-01 A HEURISTIC DECISION MAKING MODEL TO MITIGATE ADVERSE CONSEQUENCES IN A NETWORK CENTRIC WARFARE / SENSE AND RESPOND SYSTEM

Causes of Combustion Instabilities with Passive and Active Methods of Control for practical application to Gas Turbine Engines

NASA Astrophysics Data System (ADS)

Cornwell, Michael D.

Combustion at high pressure in applications such as rocket engines and gas turbine engines commonly experience destructive combustion instabilities. These instabilities results from interactions between combustion heat release, fluid mechanics and acoustics. This research explores the significant affect of unstable fluid mechanics processes in augmenting unstable periodic combustion heat release. The frequency of the unstable heat release may shift to match one of the combustors natural acoustic frequencies which then can result in significant energy exchange from chemical to acoustic energy resulting in thermoacoustic instability. The mechanisms of the fluid mechanics in coupling combustion to acoustics are very broad with many varying mechanisms explained in detail in the first chapter. Significant effort is made in understanding these mechanisms in this research in order to find commonalities, useful for mitigating multiple instability mechanisms. The complexity of combustion instabilities makes mitigation of combustion instabilities very difficult as few mitigation methods have historically proven to be very effective for broad ranges of combustion instabilities. This research identifies turbulence intensity near the forward stagnation point and movement of the forward stagnation point as a common link in what would otherwise appear to be very different instabilities. The most common method of stabilization of both premixed and diffusion flame combustion is through the introduction of swirl. Reverse flow along the centerline is introduced to transport heat and chemically active combustion products back upstream to sustain combustion. This research develops methods to suppress the movement of the forward stagnation point without suppressing the development of the vortex breakdown process which is critical to the transport of heat and reactive species necessary for flame stabilization. These methods are useful in suppressing the local turbulence at the forward stagnation point, limiting dissipation of heat and reactive species significantly improving stability. Combustion hardware is developed and tested to demonstrate the stability principles developed as part of this research. In order to more completely understand combustion instability a very unique method of combustion was researched where there are no discrete points of combustion initiation such as the forward stagnation point typical in many combustion systems including swirl and jet wake stabilized combustion. This class of combustion which has empirical evidence of great stability and efficient combustion with low CO, NOx and UHC emissions is described as high oxidization temperature distributed combustion. This mechanism of combustion is shown to be stable largely because there are no stagnations points susceptible to fluid mechanic perturbations. The final topic of research is active combustion control by fuel modulation. This may be the only practical method of controlling most instabilities with a single technique. As there are many papers reporting active combustion control algorithms this research focused on the complexities of the physics of fuel modulation at frequencies up to 1000 Hz with proportionally controlled flow amplitude. This research into the physics of high speed fluid movement, oscillation mechanical mechanisms and electromagnetics are demonstrated by development and testing of a High Speed Latching Oscillator Valve.

Overview of the Ares I Scale Model Acoustic Test Program

NASA Technical Reports Server (NTRS)

Counter, Douglas D.; Houston, Janice D.

2011-01-01

Launch environments, such as lift-off acoustic (LOA) and ignition overpressure (IOP), are important design factors for any vehicle and are dependent upon the design of both the vehicle and the ground systems. LOA environments are used directly in the development of vehicle vibro-acoustic environments and IOP is used in the loads assessment. The NASA Constellation Program had several risks to the development of the Ares I vehicle linked to LOA. The risks included cost, schedule and technical impacts for component qualification due to high predicted vibro-acoustic environments. One solution is to mitigate the environment at the component level. However, where the environment is too severe for component survivability, reduction of the environment itself is required. The Ares I Scale Model Acoustic Test (ASMAT) program was implemented to verify the Ares I LOA and IOP environments for the vehicle and ground systems including the Mobile Launcher (ML) and tower. An additional objective was to determine the acoustic reduction for the LOA environment with an above deck water sound suppression system. ASMAT was a development test performed at the Marshall Space Flight Center (MSFC) East Test Area (ETA) Test Stand 116 (TS 116). The ASMAT program is described in this presentation.

48 CFR 3.1104 - Mitigation or waiver.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Mitigation or waiver. 3... for Contractor Employees Performing Acquisition Functions 3.1104 Mitigation or waiver. (a) In... impose conditions that provide mitigation of a personal conflict of interest or grant a waiver. (c) This...

48 CFR 3.1104 - Mitigation or waiver.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Mitigation or waiver. 3... for Contractor Employees Performing Acquisition Functions 3.1104 Mitigation or waiver. (a) In... impose conditions that provide mitigation of a personal conflict of interest or grant a waiver. (c) This...

48 CFR 3.1104 - Mitigation or waiver.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Mitigation or waiver. 3... for Contractor Employees Performing Acquisition Functions 3.1104 Mitigation or waiver. (a) In... impose conditions that provide mitigation of a personal conflict of interest or grant a waiver. (c) This...

The effectiveness of mitigation for reducing radon risk in single-family Minnesota homes.

PubMed

Steck, Daniel J

2012-09-01

Increased lung cancer incidence has been linked with long-term exposure to elevated residential radon. Experimental studies have shown that soil ventilation can be effective in reducing radon concentrations in single-family homes. Most radon mitigation systems in the U.S. are installed by private contractors. The long-term effectiveness of these systems is not well known, since few state radon programs regulate or independently confirm post-mitigation radon concentrations. The effectiveness of soil ventilation systems in Minnesota was measured for 140 randomly selected clients of six professional mitigators. Homeowners reported pre-mitigation radon screening concentrations that averaged 380 Bq m (10.3 pCi L). Long term post-mitigation radon measurements on the two lowest floors show that, even years after mitigation, 97% of these homes have concentrations below the 150 Bq m U.S. Environmental Protection Agency action level. The average post-mitigation radon in the houses was 30 Bq m, an average observed reduction of >90%. If that reduction was maintained over the lifetime of the 1.2 million Minnesotans who currently reside in single-family homes with living space radon above the EPA action level, approximately 50,000 lives could be extended for nearly two decades by preventing radon-related lung cancers.

30 CFR 75.1107-8 - Fire suppression devices; extinguishant supply systems.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Fire suppression devices; extinguishant supply systems. (a) Fire suppression systems using water or... equivalent protective devices and a rising stem or other visual indicator-type shutoff valve. (b) Water supplies for fire suppression devices installed on underground equipment may be maintained in mounted water...

30 CFR 75.1107-8 - Fire suppression devices; extinguishant supply systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Fire suppression devices; extinguishant supply systems. (a) Fire suppression systems using water or... equivalent protective devices and a rising stem or other visual indicator-type shutoff valve. (b) Water supplies for fire suppression devices installed on underground equipment may be maintained in mounted water...

30 CFR 75.1107-8 - Fire suppression devices; extinguishant supply systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Fire suppression devices; extinguishant supply systems. (a) Fire suppression systems using water or... equivalent protective devices and a rising stem or other visual indicator-type shutoff valve. (b) Water supplies for fire suppression devices installed on underground equipment may be maintained in mounted water...

Which offers more scope to suppress river phytoplankton blooms: reducing nutrient pollution or riparian shading?

PubMed

Hutchins, M G; Johnson, A C; Deflandre-Vlandas, A; Comber, S; Posen, P; Boorman, D

2010-10-01

River flow and quality data, including chlorophyll-a as a surrogate for river phytoplankton biomass, were collated for the River Ouse catchment in NE England, which according to established criteria is a largely unpolluted network. Against these data, a daily river quality model (QUESTOR) was setup and successfully tested. Following a review, a river quality classification scheme based on phytoplankton biomass was proposed. Based on climate change predictions the model indicated that a shift from present day oligotrophic/mesotrophic conditions to a mesotrophic/eutrophic system could occur by 2080. Management options were evaluated to mitigate against this predicted decline in quality. Reducing nutrient pollution was found to be less effective at suppressing phytoplankton growth than the less costly option of establishing riparian shading. In the Swale tributary, ongoing efforts to reduce phosphorus loads in sewage treatment works will only reduce peak (95th percentile) phytoplankton by 11%, whereas a reduction of 44% is possible if riparian tree cover is also implemented. Likewise, in the Ure, whilst reducing nitrate loads by curtailing agriculture in the headwaters may bring about a 10% reduction, riparian shading would instead reduce levels by 47%. Such modelling studies are somewhat limited by insufficient field data but offer a potentially very valuable tool to assess the most cost-effective methods of tackling effects of eutrophication. Copyright 2010 Elsevier B.V. All rights reserved.

Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardium.

PubMed

Zhao, Yu Tina; Du, Jianfeng; Chen, Youfang; Tang, Yaoliang; Qin, Gangjian; Lv, Guorong; Zhuang, Shougang; Zhao, Ting C

2015-12-24

Recent evidence has demonstrated that cardiac progenitor cells play an essential role in the induction of angiomyogenesis in infarcted myocardium. We and others have shown that engraftment of c-kit(+) cardiac stem cells (CSCs) into infarcted hearts led to myocardium regeneration and neovascularization, which was associated with an improvement of ventricular function. The purpose of this study is aimed at investigating the functional role of transcription factor (TF) Oct3/4 in facilitating CSCs to promote myocardium regeneration and preserve cardiac performance in the post-MI heart. c-kit(+) CSCs were isolated from adult hearts and re-introduced into the infarcted myocardium in which the mouse MI model was created by permanent ligation of the left anterior descending artery (LAD). The Oct3/4 of CSCs was inhibited by transfection of Oct3/4 siRNA, and transfection of CSCs with control siRNA serves as control groups. Myocardial functions were evaluated by echocardiographic measurement. Histological analysis was employed to assess newly formed cardiogenesis, neovascularization, and cell proliferations. Terminal deoxynucleotidyltransferase (TdT) nick-end labeling (TUNEL) was carried out to assess apoptotic cardiomyocytes. Real time polymerase chain reaction and Western blot were carried out to evaluate the level of Oct 3/4 in CSCs. Two weeks after engraftment, CSCs increased ventricular functional recovery as shown by a serial echocardiographic measurement, which is concomitant with the suppression of cardiac hypertrophy and attenuation of myocardial interstitial fibrosis. Suppression of Oct 3/4 of CSCs abrogated functional improvements and mitigated the hypertrophic response and cardiac remodeling. Transplantation of c-kit(+) CSCs into MI hearts promoted cardiac regeneration and neovascularization, which were abolished with the knockdown of Oct3/4. Additionally, suppression of Oct3/4 abrogated myocyte proliferation in the CSC-engrafted myocardium. Our results indicate that CSCs-derived cardiac regeneration improves the restoration of cardiac function and is mediated through Oct 3/4.

National Standard of the Russian Federation for Space Debris Mitigation

NASA Astrophysics Data System (ADS)

Loginov, S.; Yakovlev, M.; Mikhailov, M.; Popkova, L.

2009-03-01

Normative and technical document that define requirements for the mitigation of human-produced near-earth space pollution develops in Russian Federation.NATIONAL STANDARD of the Russian Federation GOST R 52925-2008 «SPACE TECHNOLOGY ITEMS. General Requirements on Space Systems for the Mitigation of Human-Produced near-Earth Space Pollution» was approved in 2008 and entered into force since 1st January of 2009. Requirements of this standard harmonized with requirements of «UN SPACE DEBRIS MITIGATION GUIDELINESÈ»This standard consists of six parts:- Scope;- References to Standards;- Terms & Definitions;- Abbreviations;- General Provisions;- General Requirements on Space Systems for the Mitigation of Human-Produced near-Earth Space Pollution.

Minding the Cyber-Physical Gap: Model-Based Analysis and Mitigation of Systemic Perception-Induced Failure.

PubMed

Mordecai, Yaniv; Dori, Dov

2017-07-17

The cyber-physical gap (CPG) is the difference between the 'real' state of the world and the way the system perceives it. This discrepancy often stems from the limitations of sensing and data collection technologies and capabilities, and is inevitable at some degree in any cyber-physical system (CPS). Ignoring or misrepresenting such limitations during system modeling, specification, design, and analysis can potentially result in systemic misconceptions, disrupted functionality and performance, system failure, severe damage, and potential detrimental impacts on the system and its environment. We propose CPG-Aware Modeling & Engineering (CPGAME), a conceptual model-based approach to capturing, explaining, and mitigating the CPG. CPGAME enhances the systems engineer's ability to cope with CPGs, mitigate them by design, and prevent erroneous decisions and actions. We demonstrate CPGAME by applying it for modeling and analysis of the 1979 Three Miles Island 2 nuclear accident, and show how its meltdown could be mitigated. We use ISO-19450:2015-Object Process Methodology as our conceptual modeling framework.

Treating autism by targeting the temporal lobes.

PubMed

Chi, Richard P; Snyder, Allan W

2014-11-01

Compelling new findings suggest that an early core signature of autism is a deficient left anterior temporal lobe response to language and an atypical over-activation of the right anterior temporal lobe. Intriguingly, our recent results from an entirely different line of reasoning and experiments also show that applying cathodal stimulation (suppressing) at the left anterior temporal lobe together with anodal stimulation (facilitating) at the right anterior temporal lobe, by transcranial direct current stimulation (tDCS), can induce some autistic-like cognitive abilities in otherwise normal adults. If we could briefly induce autistic like cognitive abilities in healthy individuals, it follows that we might be able to mitigate some autistic traits by reversing the above stimulation protocol, in an attempt to restore the typical dominance of the left anterior temporal lobe. Accordingly, we hypothesize that at least some autistic traits can be mitigated, by applying anodal stimulation (facilitating) at the left anterior temporal lobe together with cathodal stimulation (suppressing) at the right anterior temporal lobe. Our hypothesis is supported by strong convergent evidence that autistic symptoms can emerge and later reverse due to the onset and subsequent recovery of various temporal lobe (predominantly the left) pathologies. It is also consistent with evidence that the temporal lobes (especially the left) are a conceptual hub, critical for extracting meaning from lower level sensory information to form a coherent representation, and that a deficit in the temporal lobes underlies autistic traits. Copyright © 2014 Elsevier Ltd. All rights reserved.

Radon mitigation for the SuperCDMS SNOLAB dark matter experiment

NASA Astrophysics Data System (ADS)

Street, J.; Bunker, R.; Miller, E. H.; Schnee, R. W.; Snyder, S.; So, J.

2018-01-01

A potential background for the SuperCDMS SNOLAB dark matter experiment is from radon daughters that have plated out onto detector surfaces. To reach desired backgrounds, understanding plate-out rates during detector fabrication as well as mitigating radon in surrounding air is critical. A radon mitigated cleanroom planned at SNOLAB builds upon a system commissioned at the South Dakota School of Mines & Technology (SD Mines). The ultra-low radon cleanroom at SD Mines has air supplied by a vacuum-swing-adsorption radon mitigation system that has achieved >1000× reduction for a cleanroom activity consistent with zero and <0.067 Bq m-3 at 90% confidence. Our simulation of this system, validated against calibration data, provides opportunity for increased understanding and optimization for this and future systems.

Complex systems analysis of series of blackouts: cascading failure, critical points, and self-organization.

PubMed

Dobson, Ian; Carreras, Benjamin A; Lynch, Vickie E; Newman, David E

2007-06-01

We give an overview of a complex systems approach to large blackouts of electric power transmission systems caused by cascading failure. Instead of looking at the details of particular blackouts, we study the statistics and dynamics of series of blackouts with approximate global models. Blackout data from several countries suggest that the frequency of large blackouts is governed by a power law. The power law makes the risk of large blackouts consequential and is consistent with the power system being a complex system designed and operated near a critical point. Power system overall loading or stress relative to operating limits is a key factor affecting the risk of cascading failure. Power system blackout models and abstract models of cascading failure show critical points with power law behavior as load is increased. To explain why the power system is operated near these critical points and inspired by concepts from self-organized criticality, we suggest that power system operating margins evolve slowly to near a critical point and confirm this idea using a power system model. The slow evolution of the power system is driven by a steady increase in electric loading, economic pressures to maximize the use of the grid, and the engineering responses to blackouts that upgrade the system. Mitigation of blackout risk should account for dynamical effects in complex self-organized critical systems. For example, some methods of suppressing small blackouts could ultimately increase the risk of large blackouts.

Mitigation of ^{42}Ar/^{42}K background for the GERDA Phase II experiment

NASA Astrophysics Data System (ADS)

Lubashevskiy, A.; Agostini, M.; Budjáš, D.; Gangapshev, A.; Gusev, K.; Heisel, M.; Klimenko, A.; Lazzaro, A.; Lehnert, B.; Pelczar, K.; Schönert, S.; Smolnikov, A.; Walter, M.; Zuzel, G.

2018-01-01

Background coming from the ^{42}Ar decay chain is considered to be one of the most relevant for the Gerda experiment, which searches for the neutrinoless double beta decay of ^{76}Ge. The sensitivity strongly relies on the absence of background around the Q-value of the decay. Background coming from ^{42}K, a progeny of ^{42}Ar, can contribute to that background via electrons from the continuous spectrum with an endpoint at 3.5 MeV. Research and development on the suppression methods targeting this source of background were performed at the low-background test facility LArGe . It was demonstrated that by reducing ^{42}K ion collection on the surfaces of the broad energy germanium detectors in combination with pulse shape discrimination techniques and an argon scintillation veto, it is possible to suppress ^{42}K background by three orders of magnitude. This is sufficient for Phase II of the Gerda experiment.

Suppressed decomposition of organometal halide perovskites by impermeable electron-extraction layers in inverted solar cells

PubMed Central

Brinkmann, K.O.; Zhao, J.; Pourdavoud, N.; Becker, T.; Hu, T.; Olthof, S.; Meerholz, K.; Hoffmann, L.; Gahlmann, T.; Heiderhoff, R.; Oszajca, M. F.; Luechinger, N. A.; Rogalla, D.; Chen, Y.; Cheng, B.; Riedl, T

2017-01-01

The area of thin-film photovoltaics has been overwhelmed by organometal halide perovskites. Unfortunately, serious stability concerns arise with perovskite solar cells. For example, methyl-ammonium lead iodide is known to decompose in the presence of water and, more severely, even under inert conditions at elevated temperatures. Here, we demonstrate inverted perovskite solar cells, in which the decomposition of the perovskite is significantly mitigated even at elevated temperatures. Specifically, we introduce a bilayered electron-extraction interlayer consisting of aluminium-doped zinc oxide and tin oxide. We evidence tin oxide grown by atomic layer deposition does form an outstandingly dense gas permeation barrier that effectively hinders the ingress of moisture towards the perovskite and—more importantly—it prevents the egress of decomposition products of the perovskite. Thereby, the overall decomposition of the perovskite is significantly suppressed, leading to an outstanding device stability. PMID:28067308

Physiological and Metabolic Effects of 5-Aminolevulinic Acid for Mitigating Salinity Stress in Creeping Bentgrass

PubMed Central

Yang, Zhimin; Chang, Zuoliang; Sun, Lihong; Yu, Jingjin; Huang, Bingru

2014-01-01

The objectives of this study were to determine whether foliar application of a chlorophyll precursor, 5-aminolevulinic acid (ALA), could mitigate salinity stress damages in perennial grass species by regulating photosynthetic activities, ion content, antioxidant metabolism, or metabolite accumulation. A salinity-sensitive perennial grass species, creeping bentgrass (Agrostis stolonifera), was irrigated daily with 200 mM NaCl for 28 d, which were foliar sprayed with water or ALA (0.5 mg L−1) weekly during the experiment in growth chamber. Foliar application of ALA was effective in mitigating physiological damage resulting from salinity stress, as manifested by increased turf quality, shoot growth rate, leaf relative water content, chlorophyll content, net photosynthetic rate, stomatal conductance and transpiration rate. Foliar application of ALA also alleviated membrane damages, as shown by lower membrane electrolyte leakage and lipid peroxidation, which was associated with increases in the activities of antioxidant enzymes. Leaf content of Na+ was reduced and the ratio of K+/Na+ was increased with ALA application under salinity stress. The positive effects of ALA for salinity tolerance were also associated with the accumulation of organic acids (α-ketoglutaric acid, succinic acid, and malic acid), amino acids (alanine, 5-oxoproline, aspartic acid, and γ -aminobutyric acid), and sugars (glucose, fructose, galactose, lyxose, allose, xylose, sucrose, and maltose). ALA-mitigation of physiological damages by salinity could be due to suppression of Na+ accumulation and enhanced physiological and metabolic activities related to photosynthesis, respiration, osmotic regulation, and antioxidant defense. PMID:25551443

Dynamics Control Approaches to Improve Vibratory Environment of the Helicopter Aircrew

NASA Astrophysics Data System (ADS)

Wickramasinghe, Viresh Kanchana

Although helicopter has become a versatile mode of aerial transportation, high vibration levels leads to poor ride quality for its passengers and aircrew. Undesired vibration transmitted through the helicopter seats have been known to cause fatigue and discomfort to the aircrew in the short-term as well as neck strain and back pain injuries due to long-term exposure. This research study investigated the use of novel active as well as passive methodologies integrated in helicopter seats to mitigate the aircrew exposure to high vibration levels. Due to significantly less certification effort required to modify the helicopter seat structure, application of novel technologies to the seat is more practical compared to flight critical components such as the main rotor to reduce aircrew vibration. In particular, this research effort developed a novel adaptive seat mount approach based on active vibration control technology. This novel design that incorporated two stacked piezoelectric actuators as active struts increases the bending stiffness to avoid the low frequency resonance while generating forces to counteract higher harmonic vibration peaks. A real-time controller implemented using a feed-forward algorithm based on adaptive notches counteracted the forced vibration peaks while a robust feedback control algorithm suppressed the resonance modes. The effectiveness of the adaptive seat mount system was demonstrated through extensive closed-loop control tests on a full-scale helicopter seat using representative helicopter floor vibration profiles. Test results concluded that the proposed adaptive seat mount approach based on active control technology is a viable solution for the helicopter seat vibration control application. In addition, a unique flight test using a Bell-412 helicopter demonstrated that the aircrew is exposed to high levels of vibration during flight and that the whole body vibration spectrum varied substantially depending on operating conditions as well as the aircrew configurations. This investigation also demonstrated the suitability of integrating novel energy absorbing cushion materials to the seat as a low cost solution to improve aircrew vibration suppression. Therefore, it was recommended to pursue certification of novel seat cushion materials as a near-term solution to mitigate undesirable occupational health hazards in helicopter aircrew due to vibration exposure.

UNDERSTANDING METHANE EMISSIONS SOURCES AND VIABLE MITIGATION MEASURES IN THE NATURAL GAS TRANSMISSION SYSTEMS: RUSSIAN AND U.S. EXPERIENCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ishkov, A.; Akopova, Gretta; Evans, Meredydd

This article will compare the natural gas transmission systems in the U.S. and Russia and review experience with methane mitigation technologies in the two countries. Russia and the United States (U.S.) are the world's largest consumers and producers of natural gas, and consequently, have some of the largest natural gas infrastructure. This paper compares the natural gas transmission systems in Russia and the U.S., their methane emissions and experiences in implementing methane mitigation technologies. Given the scale of the two systems, many international oil and natural gas companies have expressed interest in better understanding the methane emission volumes and trendsmore » as well as the methane mitigation options. This paper compares the two transmission systems and documents experiences in Russia and the U.S. in implementing technologies and programs for methane mitigation. The systems are inherently different. For instance, while the U.S. natural gas transmission system is represented by many companies, which operate pipelines with various characteristics, in Russia predominately one company, Gazprom, operates the gas transmission system. However, companies in both countries found that reducing methane emissions can be feasible and profitable. Examples of technologies in use include replacing wet seals with dry seals, implementing Directed Inspection and Maintenance (DI&M) programs, performing pipeline pump-down, applying composite wrap for non-leaking pipeline defects and installing low-bleed pneumatics. The research methodology for this paper involved a review of information on methane emissions trends and mitigation measures, analytical and statistical data collection; accumulation and analysis of operational data on compressor seals and other emission sources; and analysis of technologies used in both countries to mitigate methane emissions in the transmission sector. Operators of natural gas transmission systems have many options to reduce natural gas losses. Depending on the value of gas, simple, low-cost measures, such as adjusting leaking equipment components, or larger-scale measures, such as installing dry seals on compressors, can be applied.« less

The Effect of Mitigation Policy on Regional Climate Impacts on the U.S. Electric Sector

NASA Astrophysics Data System (ADS)

Cohen, S. M.; Sun, Y.; Strzepek, K.; McFarland, J.; Boehlert, B.; Fant, C.

2017-12-01

Climate change can influence the U.S. electricity sector in many ways, the nature of which can be shaped by energy and environmental policy choices. Changing temperatures affect electricity demand largely through heating and cooling needs, and temperatures also affect generation and transmission system performance. Altered precipitation patterns affect the regional and seasonal distribution of surface water runoff, which changes hydropower operation and thermal cooling water availability. The extent to which these stimuli influence U.S. power sector operation and planning will depend to some extent on whether or not proactive policies are enacted to mitigate these impacts. Mitigation policies such as CO2 emissions limits or technology restrictions can change the makeup of the electricity system while reducing the extent of climate change itself. We use the National Renewable Energy Laboratory's Regional Energy Deployment System (ReEDS), a U.S. electric sector capacity expansion model, to explore electric sector evolution through 2050 under alternative climate and policy assumptions. The model endogenously represents climate impacts on load, power system performance, cooling water availability, and hydropower, allowing internally consistent system responses to climate change along with projected technology, market, and policy conditions. We compare climate impacts across 5 global circulation models for a 8.5 W/m2 representative concentration pathway (RCP) without a climate mitigation policy and a 4.5 W/m2 RCP with climate mitigation. Climate drivers affect the capacity and generation mix at the national and regional levels, with relative growth of wind, solar, and natural gas-based technologies depending on local electricity system characteristics. These differences affect regional economic impacts, measured here as changes to electricity price and system costs. Mitigation policy reduces the economic and system impacts of climate change largely by moderating temperature-induced load but also by lessening water- and temperature-based performance constraints. Policy impacts are nuanced and region-specific, and this analysis underscores the importance of climate mitigation policy to regional electricity system planning decisions.

Climate change mitigation and adaptation in the land use sector: from complementarity to synergy.

PubMed

Duguma, Lalisa A; Minang, Peter A; van Noordwijk, Meine

2014-09-01

Currently, mitigation and adaptation measures are handled separately, due to differences in priorities for the measures and segregated planning and implementation policies at international and national levels. There is a growing argument that synergistic approaches to adaptation and mitigation could bring substantial benefits at multiple scales in the land use sector. Nonetheless, efforts to implement synergies between adaptation and mitigation measures are rare due to the weak conceptual framing of the approach and constraining policy issues. In this paper, we explore the attributes of synergy and the necessary enabling conditions and discuss, as an example, experience with the Ngitili system in Tanzania that serves both adaptation and mitigation functions. An in-depth look into the current practices suggests that more emphasis is laid on complementarity-i.e., mitigation projects providing adaptation co-benefits and vice versa rather than on synergy. Unlike complementarity, synergy should emphasize functionally sustainable landscape systems in which adaptation and mitigation are optimized as part of multiple functions. We argue that the current practice of seeking co-benefits (complementarity) is a necessary but insufficient step toward addressing synergy. Moving forward from complementarity will require a paradigm shift from current compartmentalization between mitigation and adaptation to systems thinking at landscape scale. However, enabling policy, institutional, and investment conditions need to be developed at global, national, and local levels to achieve synergistic goals.

Northeast Oregon Wildlife Mitigation Project : Final Environmental Assessment.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration; Nez Perce Tribe

1996-08-01

Development of the hydropower system in the Columbia River Basin has had far-reaching effects on many species of wildlife. The Bonneville Power Administration (BPA) is responsible for mitigating the loss of wildlife habitat caused by the Federal portion of this system, as allocated to the purpose of power production. BPA needs to mitigate for loss of wildlife habitat in the Snake River Subbasin.

A Combined Energy Management Algorithm for Wind Turbine/Battery Hybrid System

NASA Astrophysics Data System (ADS)

Altin, Necmi; Eyimaya, Süleyman Emre

2018-03-01

From an energy management standpoint, natural phenomena such as solar irradiation and wind speed are uncontrolled variables, so the correlation between the energy generated by renewable energy sources and energy demand cannot always be predicted. For this reason, energy storage systems are used to provide more efficient renewable energy systems. In these systems, energy management systems are used to control the energy storage system and establish a balance between the generated power and the power demand. In addition, especially in wind turbines, rapidly varying wind speeds cause wind power fluctuations, which threaten the power system stability, especially at high power levels. Energy storage systems are also used to mitigate the power fluctuations and sustain the power system's stability. In these systems, another controller which controls the energy storage system power to mitigate power fluctuations is required. These two controllers are different from each other. In this study, a combined energy management algorithm is proposed which can perform both as an energy control system and a power fluctuation mitigation system. The proposed controller is tested with wind energy conversion system modeled in MATLAB/Simulink. Simulation results show that the proposed controller acts as an energy management system while, at the same time, mitigating power fluctuations.

ASSESSMENT PROTOCOLS - DURABILITY OF PERFORMANCE OF A HOME RADON REDUCTION SYSTEM FOR SUB-SLAB DEPRESSURIZA- TION SYSTEMS

EPA Science Inventory

This handbook contains protocols that compare the immediate performance of subslab depressurization (SSD) mitigation system with performance months or years later. These protocols provide a methodology to test SSD radon mitigation systems in situ to determine long-term performanc...

Synergy of debris mitigation and removal

NASA Astrophysics Data System (ADS)

Lewis, Hugh G.; White, Adam E.; Crowther, Richard; Stokes, Hedley

2012-12-01

Since the end of the 20th Century there has been considerable effort made to devise mitigation measures to limit the growth of the debris population. This activity has led to the implementation of a "25-year rule" by a number of space-faring nations for the post-mission disposal of spacecraft and orbital stages intersecting the Low Earth Orbit (LEO) region. Through the use of projections made by computer models, it was anticipated that this 25-year rule, together with passivation and suppression of mission-related debris, would be sufficient to prevent the unconstrained growth of the LEO debris population. In the last decade both the LEO debris environment and the debris modelling capability have seen significant changes. In particular, recent population growth has been driven by a number of major break-ups, including the intentional destruction of the Fengyun-1C spacecraft and the collision between Iridium 33 and Cosmos 2251. State-of-the-art evolutionary models indicate that the LEO debris population will continue to grow in spite of good compliance with the commonly adopted mitigation measures and even in the absence of new launches. Consequently, this has led to considerable interest in the development of remediation measures and, especially, in debris removal. In this paper, we present a new and large study of debris mitigation and removal using the University of Southampton's evolutionary model, DAMAGE, together with the latest MASTER model population of objects ≥10 cm in LEO. Here, we have employed a concurrent approach to mitigation and remediation, whereby changes to the PMD rule and the inclusion of other mitigation measures have been considered together with multiple removal strategies. In this way, we have been able to demonstrate the synergy of these mitigation and remediation measures and to identify potential, aggregate solutions to the space debris problem. The results suggest that reducing the PMD rule offers benefits that include an increase in the effectiveness of debris removal and a corresponding increase in the confidence that these combined measures will lead to the stabilisation of the LEO debris population.

Mitigation of methane emission from an old unlined landfill in Klintholm, Denmark using a passive biocover system.

PubMed

Scheutz, Charlotte; Pedersen, Rasmus Broe; Petersen, Per Haugsted; Jørgensen, Jørgen Henrik Bjerre; Ucendo, Inmaculada Maria Buendia; Mønster, Jacob G; Samuelsson, Jerker; Kjeldsen, Peter

2014-07-01

Methane generated at landfills contributes to global warming and can be mitigated by biocover systems relying on microbial methane oxidation. As part of a closure plan for an old unlined landfill without any gas management measures, an innovative biocover system was established. The system was designed based on a conceptual model of the gas emission patterns established through an initial baseline study. The study included construction of gas collection trenches along the slopes of the landfill where the majority of the methane emissions occurred. Local compost materials were tested as to their usefulness as bioactive methane oxidizing material and a suitable compost mixture was selected. Whole site methane emission quantifications based on combined tracer release and downwind measurements in combination with several local experimental activities (gas composition within biocover layers, flux chamber based emission measurements and logging of compost temperatures) proved that the biocover system had an average mitigation efficiency of approximately 80%. The study showed that the system also had a high efficiency during winter periods with temperatures below freezing. An economic analysis indicated that the mitigation costs of the biocover system were competitive to other existing greenhouse gas mitigation options. Copyright © 2014 Elsevier Ltd. All rights reserved.

Wildlife and Wildlife Habitat Mitigation Plan for Hungry Horse Hydroelectric Project, Final Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bissell, Gael

1985-01-01

This report describes the proposed mitigation plan for wildlife losses attributable to the construction of the Hungry Horse hydroelectric project. In this report, mitigation objectives and alternatives, the recommended mitigation projects, and the crediting system for each project are described by each target species. Mitigation objectives for each species (group) were established based on the loss estimates but tailored to the recommended projects. 13 refs., 3 figs., 19 tabs.

Suppression of wear particle induced pro-inflammatory cytokine and chemokine production in macrophages via NF-κB decoy oligodeoxynucleotide: A preliminary report

PubMed Central

Lin, Tzu-hua; Yao, Zhenyu; Sato, Taishi; Keeney, Michael; Li, Chenguang; Pajarinen, Jukka; Yang, Fan; Egashira, Kensuke; Goodman, Stuart B.

2014-01-01

Total joint replacement (TJR) is a very cost-effective surgery for end-stage arthritis. One important goal is to decrease the revision rate especially because TJR has been extended to younger patients. Continuous production of ultra-high molecular weight polyethylene (UHMWPE) wear particles induces macrophage infiltration and chronic inflammation, which can lead to peri-prosthetic osteolysis. Targeting individual pro-inflammatory cytokines directly has not reversed the osteolytic process in clinical trials, due to compensatory upregulation of other pro-inflammatory factors. We hypothesized that targeting the important transcription factor NF-κB could mitigate the inflammatory response to wear particles, potentially diminishing osteolysis. In the current study, we suppressed NF-κB activity in mouse RAW264.7 and human THP1 macrophage cell lines, as well as primary mouse and human macrophages, via competitive binding with double strand decoy oligodeoxynucleotide (ODN) containing an NF-κB binding element. We found that macrophage exposure to UHMWPE particles induced multiple pro-inflammatory cytokine and chemokine expression including TNF-α, MCP1, MIP1α and others. Importantly, the decoy ODN significantly suppressed the induced cytokine and chemokine expression in both murine and human macrophages, and resulted in suppression of macrophage recruitment. The strategic use of decoy NF-κB ODN, delivered locally, could potentially diminish particle-induced peri-prosthetic osteolysis. PMID:24814879

The rhizosphere microbial community in a multiple parallel mineralization system suppresses the pathogenic fungus Fusarium oxysporum

PubMed Central

Fujiwara, Kazuki; Iida, Yuichiro; Iwai, Takashi; Aoyama, Chihiro; Inukai, Ryuya; Ando, Akinori; Ogawa, Jun; Ohnishi, Jun; Terami, Fumihiro; Takano, Masao; Shinohara, Makoto

2013-01-01

The rhizosphere microbial community in a hydroponics system with multiple parallel mineralization (MPM) can potentially suppress root-borne diseases. This study focused on revealing the biological nature of the suppression against Fusarium wilt disease, which is caused by the fungus Fusarium oxysporum, and describing the factors that may influence the fungal pathogen in the MPM system. We demonstrated that the rhizosphere microbiota that developed in the MPM system could suppress Fusarium wilt disease under in vitro and greenhouse conditions. The microbiological characteristics of the MPM system were able to control the population dynamics of F. oxysporum, but did not eradicate the fungal pathogen. The roles of the microbiological agents underlying the disease suppression and the magnitude of the disease suppression in the MPM system appear to depend on the microbial density. F. oxysporum that survived in the MPM system formed chlamydospores when exposed to the rhizosphere microbiota. These results suggest that the microbiota suppresses proliferation of F. oxysporum by controlling the pathogen's morphogenesis and by developing an ecosystem that permits coexistence with F. oxysporum. PMID:24311557

A Framework for Engineering Stress Resilient Plants Using Genetic Feedback Control and Regulatory Network Rewiring.

PubMed

Foo, Mathias; Gherman, Iulia; Zhang, Peijun; Bates, Declan G; Denby, Katherine J

2018-05-23

Crop disease leads to significant waste worldwide, both pre- and postharvest, with subsequent economic and sustainability consequences. Disease outcome is determined both by the plants' response to the pathogen and by the ability of the pathogen to suppress defense responses and manipulate the plant to enhance colonization. The defense response of a plant is characterized by significant transcriptional reprogramming mediated by underlying gene regulatory networks, and components of these networks are often targeted by attacking pathogens. Here, using gene expression data from Botrytis cinerea-infected Arabidopsis plants, we develop a systematic approach for mitigating the effects of pathogen-induced network perturbations, using the tools of synthetic biology. We employ network inference and system identification techniques to build an accurate model of an Arabidopsis defense subnetwork that contains key genes determining susceptibility of the plant to the pathogen attack. Once validated against time-series data, we use this model to design and test perturbation mitigation strategies based on the use of genetic feedback control. We show how a synthetic feedback controller can be designed to attenuate the effect of external perturbations on the transcription factor CHE in our subnetwork. We investigate and compare two approaches for implementing such a controller biologically-direct implementation of the genetic feedback controller, and rewiring the regulatory regions of multiple genes-to achieve the network motif required to implement the controller. Our results highlight the potential of combining feedback control theory with synthetic biology for engineering plants with enhanced resilience to environmental stress.

Adipose Stem Cell Therapy Mitigates Chronic Pancreatitis via Differentiation into Acinar-like Cells in Mice.

PubMed

Sun, Zhen; Gou, Wenyu; Kim, Do-Sung; Dong, Xiao; Strange, Charlie; Tan, Yu; Adams, David B; Wang, Hongjun

2017-11-01

The objective of this study was to assess the capacity of adipose-derived mesenchymal stem cells (ASCs) to mitigate disease progression in an experimental chronic pancreatitis mouse model. Chronic pancreatitis (CP) was induced in C57BL/6 mice by repeated ethanol and cerulein injection, and mice were then infused with 4 × 10 5 or 1 × 10 6 GFP + ASCs. Pancreas morphology, fibrosis, inflammation, and presence of GFP + ASCs in pancreases were assessed 2 weeks after treatment. We found that ASC infusion attenuated pancreatic damage, preserved pancreas morphology, and reduced pancreatic fibrosis and cell death. GFP + ASCs migrated to pancreas and differentiated into amylase + cells. In further confirmation of the plasticity of ASCs, ASCs co-cultured with acinar cells in a Transwell system differentiated into amylase + cells with increased expression of acinar cell-specific genes including amylase and chymoB1. Furthermore, culture of acinar or pancreatic stellate cell lines in ASC-conditioned medium attenuated ethanol and cerulein-induced pro-inflammatory cytokine production in vitro. Our data show that a single intravenous injection of ASCs ameliorated CP progression, likely by directly differentiating into acinar-like cells and by suppressing inflammation, fibrosis, and pancreatic tissue damage. These results suggest that ASC cell therapy has the potential to be a valuable treatment for patients with pancreatitis. Copyright © 2017 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

A Review of Statistical Disclosure Control Techniques Employed by Web-Based Data Query Systems.

PubMed

Matthews, Gregory J; Harel, Ofer; Aseltine, Robert H

We systematically reviewed the statistical disclosure control techniques employed for releasing aggregate data in Web-based data query systems listed in the National Association for Public Health Statistics and Information Systems (NAPHSIS). Each Web-based data query system was examined to see whether (1) it employed any type of cell suppression, (2) it used secondary cell suppression, and (3) suppressed cell counts could be calculated. No more than 30 minutes was spent on each system. Of the 35 systems reviewed, no suppression was observed in more than half (n = 18); observed counts below the threshold were observed in 2 sites; and suppressed values were recoverable in 9 sites. Six sites effectively suppressed small counts. This inquiry has revealed substantial weaknesses in the protective measures used in data query systems containing sensitive public health data. Many systems utilized no disclosure control whatsoever, and the vast majority of those that did deployed it inconsistently or inadequately.

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.

PubMed

Seifert, Lena; Deutsch, Michael; Alothman, Sara; Alqunaibit, Dalia; Werba, Gregor; Pansari, Mridul; Pergamo, Matthew; Ochi, Atsuo; Torres-Hernandez, Alejandro; Levie, Elliot; Tippens, Daniel; Greco, Stephanie H; Tiwari, Shaun; Ly, Nancy Ngoc Giao; Eisenthal, Andrew; van Heerden, Eliza; Avanzi, Antonina; Barilla, Rocky; Zambirinis, Constantinos P; Rendon, Mauricio; Daley, Donnele; Pachter, H Leon; Hajdu, Cristina; Miller, George

2015-12-01

Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer. However, Dectin-1 deletion exacerbates liver fibro-inflammatory disease and accelerates hepatocarcinogenesis. Mechanistically, we found that Dectin-1 protects against chronic liver disease by suppressing TLR4 signaling in hepatic inflammatory and stellate cells. Accordingly, Dectin-1(-/-) mice exhibited augmented cytokine production and reduced survival in lipopolysaccharide (LPS)-mediated sepsis, whereas Dectin-1 activation was protective. We showed that Dectin-1 inhibits TLR4 signaling by mitigating TLR4 and CD14 expression, which are regulated by Dectin-1-dependent macrophage colony stimulating factor (M-CSF) expression. Our study suggests that Dectin-1 is an attractive target for experimental therapeutics in hepatic fibrosis and neoplastic transformation. More broadly, our work deciphers critical cross-talk between pattern recognition receptors and implicates a role for Dectin-1 in suppression of sterile inflammation, inflammation-induced oncogenesis, and LPS-mediated sepsis. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

A Super Energy Mitigation Nanostructure at High Impact Speed Based on Buckyball System

PubMed Central

Xu, Jun; Li, Yibing; Xiang, Yong; Chen, Xi

2013-01-01

The energy mitigation properties of buckyballs are investigated using molecular dynamics (MD) simulations. A one dimensional buckyball long chain is employed as a unit cell of granular fullerene particles. Two types of buckyballs i.e. C60 and C720 with recoverable and non-recoverable behaviors are chosen respectively. For C60 whose deformation is relatively small, a dissipative contact model is proposed. Over 90% of the total impact energy is proven to be mitigated through interfacial reflection of wave propagation, the van der Waals interaction, covalent potential energy and atomistic kinetic energy evidenced by the decent force attenuation and elongation of transmitted impact. Further, the C720 system is found to outperform its C60 counterpart and is able to mitigate over 99% of the total kinetic energy by using a much shorter chain thanks to its non-recoverable deformation which enhances the four energy dissipation terms. Systematic studies are carried out to elucidate the effects of impactor speed and mass, as well as buckyball size and number on the system energy mitigation performance. This one dimensional buckyball system is especially helpful to deal with the impactor of high impact speed but small mass. The results may shed some lights on the research of high-efficiency energy mitigation material selections and structure designs. PMID:23724082

System Design Description for the SY-101 Hydrogen Mitigation Test Project Data Acquisition and Control System (DACS-1)

DOE Office of Scientific and Technical Information (OSTI.GOV)

ERMI, A.M.

2000-01-24

This document describes the hardware and software of the computer subsystems for the Data Acquisition and Control System (DACS) used in mitigation tests conducted on waste tank 241-SY-101 at the Hanford Nuclear Reservation.

Cheetahs and wild dogs show contrasting patterns of suppression by lions.

PubMed

Swanson, Alexandra; Caro, Tim; Davies-Mostert, Harriet; Mills, Michael G L; Macdonald, David W; Borner, Markus; Masenga, Emmanuel; Packer, Craig

2014-11-01

Top predators can dramatically suppress populations of smaller predators, with cascading effects throughout communities, and this pressure is often unquestioningly accepted as a constraint on mesopredator populations. In this study, we reassess whether African lions suppress populations of cheetahs and African wild dogs and examine possible mechanisms for coexistence between these species. Using long-term records from Serengeti National Park, we tested 30 years of population data for evidence of mesopredator suppression, and we examined six years of concurrent radio-telemetry data for evidence of large-scale spatial displacement. The Serengeti lion population nearly tripled between 1966 and 1998; during this time, wild dogs declined but cheetah numbers remained largely unchanged. Prior to their local extinction, wild dogs primarily occupied low lion density areas and apparently abandoned the long-term study area as the lion population 'saturated' the region. In contrast, cheetahs mostly utilized areas of high lion density, and the stability of the cheetah population indicates that neither high levels of lion-inflicted mortality nor behavioural avoidance inflict sufficient demographic consequences to translate into population-level effects. Population data from fenced reserves in southern Africa revealed a similar contrast between wild dogs and cheetahs in their ability to coexist with lions. These findings demonstrate differential responses of subordinate species within the same guild and challenge a widespread perception that lions undermine cheetah conservation efforts. Paired with several recent studies that document fine-scale lion-avoidance by cheetahs, this study further highlights fine-scale spatial avoidance as a possible mechanism for mitigating mesopredator suppression. © 2014 The Authors. Journal of Animal Ecology © 2014 British Ecological Society.

Potential of a gonadotropin-releasing hormone vaccine to suppress musth in captive male Asian elephants (Elephas maximus).

PubMed

Somgird, Chaleamchat; Homkong, Pongpon; Sripiboon, Supaphen; Brown, Janine L; Stout, Tom A E; Colenbrander, Ben; Mahasawangkul, Sittidet; Thitaram, Chatchote

2016-01-01

Musth in adult bull elephants is a period of increased androgen concentrations ranging from a few weeks to several months. For captive elephant bull management, musth presents a serious challenge because of the aggressive behavior of musth bulls toward people and other elephants. Commercially available GnRH vaccines have been shown to suppress testicular function by interrupting the hypothalamo-pituitary-gonadal (HPG) axis in many species. The aim of this study was to test the efficacy of a GnRH vaccine in elephant bulls for suppressing the HPG axis and mitigating musth-related aggressive behavior. Five adult Asian elephant bulls (22-55 years old) were immunized with a GnRH vaccine starting with an initial injection 2-4 months before the predicted musth period, and followed by three boosters at approximately 4-week intervals. Blood samples were collected twice weekly for hormone and antibody titer analysis. An increase in GnRH antibody titers was observed in all bulls after the second or third booster, and titers remained elevated for 2-3 months after the final booster. Musth was attenuated and shortened in three bulls and postponed completely in two. We conclude that GnRH vaccination is capable of suppressing symptoms of musth in adult bull elephants. With appropriate timing, GnRH vaccination could be used to control or manage musth and aggressive behavior in captive elephant bulls. However, more work is needed to identify an optimal dose, booster interval, and vaccination schedule for complete suppression of testicular steroidogenesis. Copyright © 2015 Elsevier B.V. All rights reserved.

Nonzero-Sum Relationships in Mitigating Urban Carbon Emissions: A Dynamic Network Simulation.

PubMed

Chen, Shaoqing; Chen, Bin; Su, Meirong

2015-10-06

The "stove-pipe" way of thinking has been mostly used in mitigating carbon emissions and managing socioeconomics because of its convenience of implementation. However, systems-oriented approaches become imperative in pursuit of an efficient regulation of carbon emissions from systems as complicated as urban systems. The aim of this paper is to establish a dynamic network approach that is capable of assessing the effectiveness of carbon emissions mitigation in a more holistic way. A carbon metabolic network is constructed by modeling the carbon flows between economic sectors and environment. With the network shocked by interventions to the sectoral carbon flows, indirect emissions from the city are accounted for under certain carbon mitigation strategies. The nonzero-sum relationships between sectors and environmental components are identified based on utility analysis, which synthesize the nature of direct and indirect network interactions. The results of the case study of Beijing suggest that the stove-pipe mitigation strategies targeted the economic sectors might be not as efficient as they were expected. A direct cutting in material or energy import to the sectors may result in a rebound in indirect emissions and thus fails to achieve the carbon mitigation goal of the city as a whole. A promising way of foreseeing the dynamic mechanism of emissions is to analyze the nonzero-sum relationships between important urban components. Thinking cities as systems of interactions, the network approach is potentially a strong tool for appraising and filtering mitigation strategies of carbon emissions.

36 CFR Appendix B to Part 1234 - Alternative Certified Fire-Safety Detection and Suppression System(s)

Code of Federal Regulations, 2012 CFR

2012-07-01

... the system at the base of the main sprinkler riser. l. Fire hydrants must be located within 250 feet... Suppression System(s) 1. General. This Appendix B contains information on the Fire-safety Detection and Suppression System(s) tested by NARA through independent live fire testing that are certified to meet the...

36 CFR Appendix B to Part 1234 - Alternative Certified Fire-Safety Detection and Suppression System(s)

Code of Federal Regulations, 2014 CFR

2014-07-01

... the system at the base of the main sprinkler riser. l. Fire hydrants must be located within 250 feet... Suppression System(s) 1. General. This Appendix B contains information on the Fire-safety Detection and Suppression System(s) tested by NARA through independent live fire testing that are certified to meet the...

36 CFR Appendix B to Part 1234 - Alternative Certified Fire-Safety Detection and Suppression System(s)

Code of Federal Regulations, 2013 CFR

2013-07-01

... the system at the base of the main sprinkler riser. l. Fire hydrants must be located within 250 feet... Suppression System(s) 1. General. This Appendix B contains information on the Fire-safety Detection and Suppression System(s) tested by NARA through independent live fire testing that are certified to meet the...

Objective tests for forward looking pedestrian crash avoidance/mitigation systems.

DOT National Transportation Integrated Search

2014-06-01

This report documents the work completed by the Crash Avoidance Metrics Partnership (CAMP) Crash Imminent Braking : (CIB) Consortium during the project titled Objective Tests for Forward Looking Pedestrian Crash Avoidance/Mitigation : Systems. ...

Lunar Dust on Heat Rejection System Surfaces: Problems and Prospects

NASA Technical Reports Server (NTRS)

Gaier, James R.; Jaworske, Donald A.

2007-01-01

Heat rejection from power systems will be necessary for human and robotic activity on the lunar surface. Functional operation of such heat rejection systems is at risk of degradation as a consequence of dust accumulation. The Apollo astronauts encountered marked degradation of performance in heat rejection systems for the lunar roving vehicle, science packages, and other components. Although ground testing of dust mitigation concepts in support of the Apollo mission identified mitigation tools, the brush concept adopted by the Apollo astronauts proved essentially ineffective. A better understanding of the issues associated with the impact of lunar dust on the functional performance of heat rejection systems and its removal is needed as planning gets underway for human and robotic missions to the Moon. Renewed emphasis must also be placed on ground testing of pristine and dust-covered heat rejection system surfaces to quantify degradation and address mitigation concepts. This paper presents a review of the degradation in performance of heat rejection systems encountered on the lunar surface to-date, and will discuss current activities underway to evaluate the durability of candidate heat rejection system surfaces and current dust mitigation concepts.

Minding the Cyber-Physical Gap: Model-Based Analysis and Mitigation of Systemic Perception-Induced Failure

PubMed Central

2017-01-01

The cyber-physical gap (CPG) is the difference between the ‘real’ state of the world and the way the system perceives it. This discrepancy often stems from the limitations of sensing and data collection technologies and capabilities, and is inevitable at some degree in any cyber-physical system (CPS). Ignoring or misrepresenting such limitations during system modeling, specification, design, and analysis can potentially result in systemic misconceptions, disrupted functionality and performance, system failure, severe damage, and potential detrimental impacts on the system and its environment. We propose CPG-Aware Modeling & Engineering (CPGAME), a conceptual model-based approach to capturing, explaining, and mitigating the CPG. CPGAME enhances the systems engineer’s ability to cope with CPGs, mitigate them by design, and prevent erroneous decisions and actions. We demonstrate CPGAME by applying it for modeling and analysis of the 1979 Three Miles Island 2 nuclear accident, and show how its meltdown could be mitigated. We use ISO-19450:2015—Object Process Methodology as our conceptual modeling framework. PMID:28714910

Beetle-kill to carbon-negative bioenergy in the Rockies: stand, enterprise, and regional-scale perspectives

NASA Astrophysics Data System (ADS)

Field, J.; Paustian, K.

2016-12-01

The interior mountain West is particularly vulnerable to climate change with potential impacts including drought and wildfire intensification, and wide-scale species disruptions due to shifts in habitable elevation ranges or other effects. One such example is the current outbreak of native mountain pine and spruce beetles across the Rockies, with warmer winters, dryer summers, and a legacy of logging and fire suppression all interacting to result in infestation and unprecedented tree mortality over more than 42 million acres. Current global climate change mitigation commitments imply that shifts to renewable energy must be supplemented with widespread deployment of carbon-negative technologies such as BECCS and biochar. Carefully-designed forest bioenergy and biochar industries can play an important role in meeting these targets, valorizing woody biomass and allowing more acres to be actively managed under existing land management goals while simultaneously displacing fossil energy use and directly sequestering carbon. In this work we assess the negative emissions potential from the deployment of biochar co-producing thermochemical bioenergy technologies in the Rockies using beetle-kill wood as a feedstock, a way of leveraging a climate change driven problem for climate mitigation. We start with a review and classification of bioenergy lifecycle assessment emission source categories, clarifying the differences in mechanism and confidence around emissions sources, offsets, sequestration, and leakage effects. Next we develop methods for modeling ecosystem carbon response to biomass removals at the stand scale, considering potential species shifts and regrowth rates under different harvest systems deployed in different areas. We then apply a lifecycle assessment framework to evaluate the performance of a set of real-world bioenergy technologies at enterprise scale, including biomass logistics and conversion product yields. We end with an exploration of regional-scale mitigation capacity considering wide-scale deployment and potential wildfire feedback effects of harvest, highlighting the relative importance of supply chain, conversion technology, ecological, and epistemological uncertainties in realizing wide-scale negative emissions in this region.

Techniques Analysis of the Interference Suppression Algorithm in Broadband Aeronautical Multi-carrier Communication System

NASA Astrophysics Data System (ADS)

Li, Dong-xia; Ye, Qian-wen

Out-of-band radiation suppression algorithm must be used efficiently for broadband aeronautical communication system in order not to interfere the operation of the existing systems in aviation L-Band. Based on the simple introduction of the broadband aeronautical multi-carrier communication (B-AMC) system model, several sidelobe suppression techniques in orthogonal frequency multiplexing (OFDM) system are presented and analyzed so as to find a suitable algorithm for B-AMC system in this paper. Simulation results show that raise-cosine function windowing can suppress the out-of-band radiation of B-AMC system effectively.

Beamforming Based Full-Duplex for Millimeter-Wave Communication

PubMed Central

Liu, Xiao; Xiao, Zhenyu; Bai, Lin; Choi, Jinho; Xia, Pengfei; Xia, Xiang-Gen

2016-01-01

In this paper, we study beamforming based full-duplex (FD) systems in millimeter-wave (mmWave) communications. A joint transmission and reception (Tx/Rx) beamforming problem is formulated to maximize the achievable rate by mitigating self-interference (SI). Since the optimal solution is difficult to find due to the non-convexity of the objective function, suboptimal schemes are proposed in this paper. A low-complexity algorithm, which iteratively maximizes signal power while suppressing SI, is proposed and its convergence is proven. Moreover, two closed-form solutions, which do not require iterations, are also derived under minimum-mean-square-error (MMSE), zero-forcing (ZF), and maximum-ratio transmission (MRT) criteria. Performance evaluations show that the proposed iterative scheme converges fast (within only two iterations on average) and approaches an upper-bound performance, while the two closed-form solutions also achieve appealing performances, although there are noticeable differences from the upper bound depending on channel conditions. Interestingly, these three schemes show different robustness against the geometry of Tx/Rx antenna arrays and channel estimation errors. PMID:27455256

Enhancing radiation tolerance by controlling defect mobility and migration pathways in multicomponent single-phase alloys

DOE PAGES

Lu, Chenyang; Niu, Liangliang; Chen, Nanjun; ...

2016-12-15

A grand challenge in material science is to understand the correlation between intrinsic properties and defect dynamics. Radiation tolerant materials are in great demand for safe operation and advancement of nuclear and aerospace systems. Unlike traditional approaches that rely on microstructural and nanoscale features to mitigate radiation damage, this study demonstrates enhancement of radiation tolerance with the suppression of void formation by two orders magnitude at elevated temperatures in equiatomic single-phase concentrated solid solution alloys, and more importantly, reveals its controlling mechanism through a detailed analysis of the depth distribution of defect clusters and an atomistic computer simulation. The enhancedmore » swelling resistance is attributed to the tailored interstitial defect cluster motion in the alloys from a long-range one-dimensional mode to a short-range three-dimensional mode, which leads to enhanced point defect recombination. Finally, the results suggest design criteria for next generation radiation tolerant structural alloys.« less

Make dark matter charged again

NASA Astrophysics Data System (ADS)

Agrawal, Prateek; Cyr-Racine, Francis-Yan; Randall, Lisa; Scholtz, Jakub

2017-05-01

We revisit constraints on dark matter that is charged under a U(1) gauge group in the dark sector, decoupled from Standard Model forces. We find that the strongest constraints in the literature are subject to a number of mitigating factors. For instance, the naive dark matter thermalization timescale in halos is corrected by saturation effects that slow down isotropization for modest ellipticities. The weakened bounds uncover interesting parameter space, making models with weak-scale charged dark matter viable, even with electromagnetic strength interaction. This also leads to the intriguing possibility that dark matter self-interactions within small dwarf galaxies are extremely large, a relatively unexplored regime in current simulations. Such strong interactions suppress heat transfer over scales larger than the dark matter mean free path, inducing a dynamical cutoff length scale above which the system appears to have only feeble interactions. These effects must be taken into account to assess the viability of darkly-charged dark matter. Future analyses and measurements should probe a promising region of parameter space for this model.

A Built-In Strategy to Mitigate Transgene Spreading from Genetically Modified Corn

PubMed Central

Li, Jing; Yu, Hui; Zhang, Fengzhen; Lin, Chaoyang; Gao, Jianhua; Fang, Jun; Ding, Xiahui; Shen, Zhicheng; Xu, Xiaoli

2013-01-01

Transgene spreading is a major concern in cultivating genetically modified (GM) corn. Cross-pollination may cause the spread of transgenes from GM cornfields to conventional fields. Occasionally, seed lot contamination, volunteers, mixing during sowing, harvest, and trade can also lead to transgene escape. Obviously, new biological confinement technologies are highly desired to mitigate transgene spreading in addition to physical separation and isolation methods. In this study, we report the development of a built-in containment method to mitigate transgene spreading in corn. In this method, an RNAi cassette for suppressing the expression of the nicosulfuron detoxifying enzyme CYP81A9 and an expression cassette for the glyphosate tolerant 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene G10 were constructed and transformed into corn via Agrobacterium-mediated transformation. The GM corn plants that were generated were found to be sensitive to nicosulfuron but resistant to glyphosate, which is exactly the opposite of conventional corn. Field tests demonstrated that GM corn plants with silenced CYP81A9 could be killed by applying nicosulfuron at 40 g/ha, which is the recommended dose for weed control in cornfields. This study suggests that this built-in containment method for controlling the spread of corn transgenes is effective and easy to implement. PMID:24324711

Influence of arbuscular mycorrhizae on biomass production and nitrogen fixation of berseem clover plants subjected to water stress.

PubMed

Saia, Sergio; Amato, Gaetano; Frenda, Alfonso Salvatore; Giambalvo, Dario; Ruisi, Paolo

2014-01-01

Several studies, performed mainly in pots, have shown that arbuscular mycorrhizal symbiosis can mitigate the negative effects of water stress on plant growth. No information is available about the effects of arbuscular mycorrhizal symbiosis on berseem clover growth and nitrogen (N) fixation under conditions of water shortage. A field experiment was conducted in a hilly area of inner Sicily, Italy, to determine whether symbiosis with AM fungi can mitigate the detrimental effects of drought stress (which in the Mediterranean often occurs during the late period of the growing season) on forage yield and symbiotic N2 fixation of berseem clover. Soil was either left under water stress (i.e., rain-fed conditions) or the crop was well-watered. Mycorrhization treatments consisted of inoculation of berseem clover seeds with arbuscular mycorrhizal spores or suppression of arbuscular mycorrhizal symbiosis by means of fungicide treatments. Nitrogen biological fixation was assessed using the 15N-isotope dilution technique. Arbuscular mycorrhizal symbiosis was able to mitigate the negative effect of water stress on berseem clover grown in a typical semiarid Mediterranean environment. In fact, under water stress conditions, arbuscular mycorrhizal symbiosis resulted in increases in total biomass, N content, and N fixation, whereas no effect of crop mycorrhization was observed in the well-watered treatment.

75 FR 14658 - Invitation for Public Comment on Mitigation Options for Global Positioning System Satellite...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-26

... use with the SVN 49 satellite and will not be implemented for any other GPS satellite. Responses from.... Air Force GPS Wing to discuss the mitigation options. These will be held on March 26, 2010 and April... without the other mitigations. All mitigations are intended for use with SVN 49 only and no changes will...

Pollution Swapping in Agricultural Systems: deciding between mitigation measures with conflicting outcomes

NASA Astrophysics Data System (ADS)

Quinton, John; Stevens, Carly

2010-05-01

Pollution swapping occurs when a mitigation option introduced to reduce one pollutant results in an increase in a different pollutant. Although the concept of pollution swapping is widely understood it has received little attention in research and policy design. This study investigated diffuse pollution mitigation options applied in combinable crop systems. They are: cover crops, residue management, no-tillage, riparian buffer zones, contour grass strips and constructed wetlands. A wide range of water and atmospheric pollutants were considered, including nitrogen, phosphorus, carbon and sulphur. It is clear from this investigation that there is no single mitigation option that will reduce all pollutants and in this poster we consider how choices may be made between mitigation measures which may have a positive effect on one pollutant but a negative effect on another.

Acoustic Suppression Systems and Related Methods

NASA Technical Reports Server (NTRS)

Kolaini, Ali R. (Inventor); Kern, Dennis L. (Inventor)

2013-01-01

An acoustic suppression system for absorbing and/or scattering acoustic energy comprising a plurality of acoustic targets in a containment is described, the acoustic targets configured to have resonance frequencies allowing the targets to be excited by incoming acoustic waves, the resonance frequencies being adjustable to suppress acoustic energy in a set frequency range. Methods for fabricating and implementing the acoustic suppression system are also provided.

Estimation of potential safety benefits for pedestrian crash avoidance/mitigation systems.

DOT National Transportation Integrated Search

2017-04-01

This report presents and exercises a methodology to estimate the effectiveness and potential safety benefits of production pedestrian crash avoidance/mitigation systems. The analysis focuses on light vehicles moving forward and striking a pedestrian ...

Supervisory Control and Data Acquisition (SCADA) Security Awareness In a Resource Constrained Learning Environment

DTIC Science & Technology

2014-06-16

SCADA systems. These professionals should be aware of the vulnerabilities so they can take intelligent precautions to mitigate attacks. SCADA...vulnerabilities • Describe mitigation options for protecting a system from SCADA attacks For students that go on to pursue a degree in Computer...from SCADA attacks For students who do not remain in the IT realm, this introduction provides an awareness to help them mitigate threats for their

Mitigation of laser damage on National Ignition Facility optics in volume production

NASA Astrophysics Data System (ADS)

Folta, James; Nostrand, Mike; Honig, John; Wong, Nan; Ravizza, Frank; Geraghty, Paul; Taranowski, Mike; Johnson, Gary; Larkin, Glenn; Ravizza, Doug; Peterson, John; Welday, Brian; Wegner, Paul

2013-12-01

The National Ignition Facility has recently achieved the milestone of delivering over 1.8 MJ and 500 TW of 351 nm laser energy and power on target, which required average fluences up to 9 J/cm2 (3 ns equivalent) in the final optics system. Commercial fused silica laser-grade UV optics typically have a maximum operating threshold of 5 J/cm2. We have developed an optics recycling process which enables NIF to operate above the laser damage initiation and growth thresholds. We previously reported a method to mitigate laser damage with laser ablation of the damage site to leave benign cone shaped pits. We have since developed a production facility with four mitigation systems capable of performing the mitigation protocols on full-sized (430 mm) optics in volume production. We have successfully repaired over 700 NIF optics (unique serial numbers), some of which have been recycled as many as 11 times. We describe the mitigation systems, the optics recycle loop process, and optics recycle production data.

75 FR 63732 - Requirements for Derivatives Clearing Organizations, Designated Contract Markets, and Swap...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... governance of certain DCOs, DCMs, or SEFs or to mitigate systemic risk, promote competition, or mitigate... the clearinghouses to reduce systemic risk, we have the banks now owning the clearinghouses. The... subject to [the CEA] and the avoidance of systemic risk.'' \\20\\ Clearing members contribute substantial...

The rhizosphere microbial community in a multiple parallel mineralization system suppresses the pathogenic fungus Fusarium oxysporum.

PubMed

Fujiwara, Kazuki; Iida, Yuichiro; Iwai, Takashi; Aoyama, Chihiro; Inukai, Ryuya; Ando, Akinori; Ogawa, Jun; Ohnishi, Jun; Terami, Fumihiro; Takano, Masao; Shinohara, Makoto

2013-12-01

The rhizosphere microbial community in a hydroponics system with multiple parallel mineralization (MPM) can potentially suppress root-borne diseases. This study focused on revealing the biological nature of the suppression against Fusarium wilt disease, which is caused by the fungus Fusarium oxysporum, and describing the factors that may influence the fungal pathogen in the MPM system. We demonstrated that the rhizosphere microbiota that developed in the MPM system could suppress Fusarium wilt disease under in vitro and greenhouse conditions. The microbiological characteristics of the MPM system were able to control the population dynamics of F. oxysporum, but did not eradicate the fungal pathogen. The roles of the microbiological agents underlying the disease suppression and the magnitude of the disease suppression in the MPM system appear to depend on the microbial density. F. oxysporum that survived in the MPM system formed chlamydospores when exposed to the rhizosphere microbiota. These results suggest that the microbiota suppresses proliferation of F. oxysporum by controlling the pathogen's morphogenesis and by developing an ecosystem that permits coexistence with F. oxysporum. © 2013 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

Real-time determination of the efficacy of residual disinfection to limit wastewater contamination in a water distribution system using filtration-based luminescence.

PubMed

Lee, Jiyoung; Deininger, Rolf A

2010-05-01

Water distribution systems can be vulnerable to microbial contamination through cross-connections, wastewater backflow, the intrusion of soiled water after a loss of pressure resulting from an electricity blackout, natural disaster, or intentional contamination of the system in a bioterrrorism event. The most urgent matter a water treatment utility would face in this situation is detecting the presence and extent of a contamination event in real-time, so that immediate action can be taken to mitigate the problem. The current approved microbiological detection methods are culture-based plate count methods, which require incubation time (1 to 7 days). This long period of time would not be useful for the protection of public health. This study was designed to simulate wastewater intrusion in a water distribution system. The objectives were 2-fold: (1) real-time detection of water contamination, and (2) investigation of the sustainability of drinking water systems to suppress the contamination with secondary disinfectant residuals (chlorine and chloramine). The events of drinking water contamination resulting from a wastewater addition were determined by filtration-based luminescence assay. The water contamination was detected by luminescence method within 5 minutes. The signal amplification attributed to wastewater contamination was clear-102-fold signal increase. After 1 hour, chlorinated water could inactivate 98.8% of the bacterial contaminant, while chloraminated water reduced 77.2%.

An analytical technique for predicting the characteristics of a flexible wing equipped with an active flutter-suppression system and comparison with wind-tunnel data

NASA Technical Reports Server (NTRS)

Abel, I.

1979-01-01

An analytical technique for predicting the performance of an active flutter-suppression system is presented. This technique is based on the use of an interpolating function to approximate the unsteady aerodynamics. The resulting equations are formulated in terms of linear, ordinary differential equations with constant coefficients. This technique is then applied to an aeroelastic model wing equipped with an active flutter-suppression system. Comparisons between wind-tunnel data and analysis are presented for the wing both with and without active flutter suppression. Results indicate that the wing flutter characteristics without flutter suppression can be predicted very well but that a more adequate model of wind-tunnel turbulence is required when the active flutter-suppression system is used.

Bio-prospectus of cadmium bioadsorption by lactic acid bacteria to mitigate health and environmental impacts.

PubMed

Kumar, Narendra; Kumari, Vandna; Ram, Chand; Thakur, Kiran; Tomar, Sudhir Kumar

2018-02-01

Foodstuffs and water are the key sources of cadmium biomagnifiaction. The available strategies to mitigate this problem are unproductive and expensive for practical large-scale use. Biological decontamination of metals through environmental microbes has been known since long time, whereas lactic acid bacteria (LAB) have not been extensively studied for this purpose. The LAB are known for maintaining homeostasis and suppression of pathogens in humans and animals. They also play a vital role in bioremediation of certain heavy metals. Recently in-vivo research findings strongly complement the in-vitro results in relation to decreased total body cadmium burden in animal model. This review summarizes the currently available information on impact of toxic metal (Cd) on human and animal health as well as cadmium sequestration through microbes placed broadly, whereas preeminent attention grabbed on LAB-cadmium interaction to explore their possible role in bioremediation of cadmium from foods and environment to safeguard human as well as environment health.

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.

PubMed

Lasagna-Reeves, Cristian A; de Haro, Maria; Hao, Shuang; Park, Jeehye; Rousseaux, Maxime W C; Al-Ramahi, Ismael; Jafar-Nejad, Paymaan; Vilanova-Velez, Luis; See, Lauren; De Maio, Antonia; Nitschke, Larissa; Wu, Zhenyu; Troncoso, Juan C; Westbrook, Thomas F; Tang, Jianrong; Botas, Juan; Zoghbi, Huda Y

2016-10-19

Many neurodegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disease-related proteins. As growing evidence indicates that reducing the steady-state levels of disease-causing proteins mitigates neurodegeneration in animal models, we developed a strategy to screen for genes that decrease the levels of tau, whose accumulation contributes to the pathology of both Alzheimer disease (AD) and progressive supranuclear palsy (PSP). Integrating parallel cell-based and Drosophila genetic screens, we discovered that tau levels are regulated by Nuak1, an AMPK-related kinase. Nuak1 stabilizes tau by phosphorylation specifically at Ser356. Inhibition of Nuak1 in fruit flies suppressed neurodegeneration in tau-expressing Drosophila, and Nuak1 haploinsufficiency rescued the phenotypes of a tauopathy mouse model. These results demonstrate that decreasing total tau levels is a valid strategy for mitigating tau-related neurodegeneration and reveal Nuak1 to be a novel therapeutic entry point for tauopathies. Copyright © 2016 Elsevier Inc. All rights reserved.

Wind Turbine Clutter Mitigation in Coastal UHF Radar

PubMed Central

Wang, Caijun; Jiang, Dapeng; Wen, Biyang

2014-01-01

Coastal UHF radar provides a unique capability to measure the sea surface dynamic parameters and detect small moving targets, by exploiting the low energy loss of electromagnetic waves propagating along the salty and good conducting ocean surface. It could compensate the blind zone of HF surface wave radar at close range and reach further distance than microwave radars. However, its performance is susceptible to wind turbines which are usually installed on the shore. The size of a wind turbine is much larger than the wavelength of radio waves at UHF band, which results in large radar cross section. Furthermore, the rotation of blades adds time-varying Doppler frequency to the clutter and makes the suppression difficult. This paper proposes a mitigation method which is based on the specific periodicity of wind turbine clutter and performed mainly in the time-frequency domain. Field experimental data of a newly developed UHF radar are used to verify this method, and the results prove its effectiveness. PMID:24550709

Wind turbine clutter mitigation in coastal UHF radar.

PubMed

Yang, Jing; Pan, Chao; Wang, Caijun; Jiang, Dapeng; Wen, Biyang

2014-01-01

Coastal UHF radar provides a unique capability to measure the sea surface dynamic parameters and detect small moving targets, by exploiting the low energy loss of electromagnetic waves propagating along the salty and good conducting ocean surface. It could compensate the blind zone of HF surface wave radar at close range and reach further distance than microwave radars. However, its performance is susceptible to wind turbines which are usually installed on the shore. The size of a wind turbine is much larger than the wavelength of radio waves at UHF band, which results in large radar cross section. Furthermore, the rotation of blades adds time-varying Doppler frequency to the clutter and makes the suppression difficult. This paper proposes a mitigation method which is based on the specific periodicity of wind turbine clutter and performed mainly in the time-frequency domain. Field experimental data of a newly developed UHF radar are used to verify this method, and the results prove its effectiveness.

Passivating film artificially built on LiNi0.5Mn1.5O4 by molecular layer deposition of (pentafluorophenylpropyl)trimethoxysilane

NASA Astrophysics Data System (ADS)

Chae, Seulki; Soon, Jiyong; Jeong, Hyejeong; Lee, Tae jin; Ryu, Ji Heon; Oh, Seung M.

2018-07-01

In this study, (pentafluorophenylpropyl)trimethoxysilane (PFPPS) is grafted on a nickel-doped manganese spinel (LiNi0.5Mn1.5O4, LNMO) surface to suppress the failure modes in the 5-V positive electrode; electrolyte oxidation/film deposition, acid generation, and metal (Ni and Mn) dissolution. Vapor-phase molecular layer deposition is used to deposit a uniformly covered PFPPS layer on the LNMO surface. When the Li/LNMO cell is cycled at 3.5-4.9 V (vs. Li/Li+), the PFPPS moiety on the LNMO surface remains intact (not oxidized) under the highly oxidizing condition. Several beneficial features are observed with the PFPPS grafting. The oxidative electrolyte decomposition is mitigated, which increases the Coulombic efficiency of the Li/LNMO cell. Consequently, the surface film deposition and cell polarization are reduced, improving the capacity retention. Moreover, the acid generation and metal dissolution are also mitigated.

FOLLOW-UP RADON MEASUREMENTS IN 14 MITIGATED SCHOOLS

EPA Science Inventory

The report gives results of a determination of the long-term performance of radon mitigation systems installed in U. S. EPA research schools: radon measurements were conducted in 14 schools that had been mitigated between 1988 and 1991. The measurements were made between Februar...

Hematopoietic stem cell injury induced by ionizing radiation.

PubMed

Shao, Lijian; Luo, Yi; Zhou, Daohong

2014-03-20

Exposure to ionizing radiation (IR) as the result of nuclear accidents or terrorist attacks is a significant threat and a major medical concern. Hematopoietic stem cell (HSC) injury is the primary cause of death after accidental or intentional exposure to a moderate or high dose of IR. Protecting HSCs from IR should be a primary goal in the development of novel medical countermeasures against radiation. Significant progress has been made in our understanding of the mechanisms by which IR causes HSC damage. The mechanisms include (i) induction of HSC apoptosis via the p53-Puma pathway; (ii) promotion of HSC differentiation via the activation of the G-CSF/Stat3/BATF-dependent differentiation checkpoint; (iii) induction of HSC senescence via the ROS-p38 pathway; and (iv) damage to the HSC niche. Induction of apoptosis in HSCs and hematopoietic progenitor cells is primarily responsible for IR-induced acute bone marrow (BM) injury. Long-term BM suppression caused by IR is mainly attributable to the induction of HSC senescence. However, the promotion of HSC differentiation and damage to the HSC niche can contribute to both the acute and long-term effects of IR on the hematopoietic system. In this review, we have summarized a number of recent findings that provide new insights into the mechanisms whereby IR damages HSCs. These findings will provide new opportunities for developing a mechanism-based strategy to prevent and/or mitigate IR-induced BM suppression. Antioxid.

Suppression and enhancement of decoherence in an atomic Josephson junction

NASA Astrophysics Data System (ADS)

Japha, Yonathan; Zhou, Shuyu; Keil, Mark; Folman, Ron; Henkel, Carsten; Vardi, Amichay

2016-05-01

We investigate the role of interatomic interactions when a Bose gas, in a double-well potential with a finite tunneling probability (a ‘Bose-Josephson junction’), is exposed to external noise. We examine the rate of decoherence of a system initially in its ground state with equal probability amplitudes in both sites. The noise may induce two kinds of effects: firstly, random shifts in the relative phase or number difference between the two wells and secondly, loss of atoms from the trap. The effects of induced phase fluctuations are mitigated by atom-atom interactions and tunneling, such that the dephasing rate may be suppressed by half its single-atom value. Random fluctuations may also be induced in the population difference between the wells, in which case atom-atom interactions considerably enhance the decoherence rate. A similar scenario is predicted for the case of atom loss, even if the loss rates from the two sites are equal. We find that if the initial state is number-squeezed due to interactions, then the loss process induces population fluctuations that reduce the coherence across the junction. We examine the parameters relevant for these effects in a typical atom chip device, using a simple model of the trapping potential, experimental data, and the theory of magnetic field fluctuations near metallic conductors. These results provide a framework for mapping the dynamical range of barriers engineered for specific applications and set the stage for more complex atom circuits (‘atomtronics’).

Neuroendocrine mechanisms for immune system regulation during stress in fish.

PubMed

Nardocci, Gino; Navarro, Cristina; Cortés, Paula P; Imarai, Mónica; Montoya, Margarita; Valenzuela, Beatriz; Jara, Pablo; Acuña-Castillo, Claudio; Fernández, Ricardo

2014-10-01

In the last years, the aquaculture crops have experienced an explosive and intensive growth, because of the high demand for protein. This growth has increased fish susceptibility to diseases and subsequent death. The constant biotic and abiotic changes experienced by fish species in culture are challenges that induce physiological, endocrine and immunological responses. These changes mitigate stress effects at the cellular level to maintain homeostasis. The effects of stress on the immune system have been studied for many years. While acute stress can have beneficial effects, chronic stress inhibits the immune response in mammals and teleost fish. In response to stress, a signaling cascade is triggered by the activation of neural circuits in the central nervous system because the hypothalamus is the central modulator of stress. This leads to the production of catecholamines, corticosteroid-releasing hormone, adrenocorticotropic hormone and glucocorticoids, which are the essential neuroendocrine mediators for this activation. Because stress situations are energetically demanding, the neuroendocrine signals are involved in metabolic support and will suppress the "less important" immune function. Understanding the cellular mechanisms of the neuroendocrine regulation of immunity in fish will allow the development of new pharmaceutical strategies and therapeutics for the prevention and treatment of diseases triggered by stress at all stages of fish cultures for commercial production. Copyright © 2014 Elsevier Ltd. All rights reserved.

The calcium-sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transport

PubMed Central

VanHouten, Joshua; Dann, Pamela; McGeoch, Grace; Brown, Edward M.; Krapcho, Karen; Neville, Margaret; Wysolmerski, John J.

2004-01-01

The transfer of calcium from mother to milk during lactation is poorly understood. In this report, we demonstrate that parathyroid hormone–related protein (PTHrP) production and calcium transport in mammary epithelial cells are regulated by extracellular calcium acting through the calcium-sensing receptor (CaR). The CaR becomes expressed on mammary epithelial cells at the transition from pregnancy to lactation. Increasing concentrations of calcium, neomycin, and a calcimimetic compound suppress PTHrP secretion by mammary epithelial cells in vitro, whereas in vivo, systemic hypocalcemia increases PTHrP production, an effect that can be prevented by treatment with a calcimimetic. Hypocalcemia also reduces overall milk production and calcium content, while increasing milk osmolality and protein concentrations. The changes in milk calcium content, milk osmolality, and milk protein concentration were mitigated by calcimimetic infusions. Finally, in a three-dimensional culture system that recapitulates the lactating alveolus, activation of the basolateral CaR increases transcellular calcium transport independent of its effect on PTHrP. We conclude that the lactating mammary gland can sense calcium and adjusts its secretion of calcium, PTHrP, and perhaps water in response to changes in extracellular calcium concentration. We believe this defines a homeostatic system that helps to match milk production to the availability of calcium. PMID:14966569

Reprogrammable field programmable gate array with integrated system for mitigating effects of single event upsets

NASA Technical Reports Server (NTRS)

Ng, Tak-kwong (Inventor); Herath, Jeffrey A. (Inventor)

2010-01-01

An integrated system mitigates the effects of a single event upset (SEU) on a reprogrammable field programmable gate array (RFPGA). The system includes (i) a RFPGA having an internal configuration memory, and (ii) a memory for storing a configuration associated with the RFPGA. Logic circuitry programmed into the RFPGA and coupled to the memory reloads a portion of the configuration from the memory into the RFPGA's internal configuration memory at predetermined times. Additional SEU mitigation can be provided by logic circuitry on the RFPGA that monitors and maintains synchronized operation of the RFPGA's digital clock managers.

Demonstration of adaptive optics for mitigating laser propagation through a random air-water interface

NASA Astrophysics Data System (ADS)

Land, Phillip; Majumdar, Arun K.

2016-05-01

This paper describes a new concept of mitigating signal distortions caused by random air-water interface using an adaptive optics (AO) system. This is the first time the concept of using an AO for mitigating the effects of distortions caused mainly by a random air-water interface is presented. We have demonstrated the feasibility of correcting the distortions using AO in a laboratory water tank for investigating the propagation effects of a laser beam through an airwater interface. The AO system consisting of a fast steering mirror, deformable mirror, and a Shack-Hartmann Wavefront Sensor for mitigating surface water distortions has a unique way of stabilizing and aiming a laser onto an object underneath the water. Essentially the AO system mathematically takes the complex conjugate of the random phase caused by air-water interface allowing the laser beam to penetrate through the water by cancelling with the complex conjugates. The results show the improvement of a number of metrics including Strehl ratio, a measure of the quality of optical image formation for diffraction limited optical system. These are the first results demonstrating the feasibility of developing a new sensor system such as Laser Doppler Vibrometer (LDV) utilizing AO for mitigating surface water distortions.

Experimental evidence of ion-induced instabilities in the NSLS-II storage ring

DOE PAGES

Cheng, Weixing; Li, Yongjun; Podobedov, Boris

2017-03-12

Fast ion instability has been identified as one of the most prominent instabilities in the recently constructed NSLS-II storage ring at Brookhaven National Laboratory. At a relatively low beam current (~ 25 mA) multi-bunch fills, ion-induced instabilities have already been observed during the early stages of machine commissioning. At present user operation with 250 mA in ~1000 bunches, the fast ion still remains the dominant instability, even after months of vacuum conditioning at high current. Ion-induced dipole motions of the electron beam have been suppressed using the transverse bunch-by-bunch (BxB) feedback system. However other adverse effects of this instability, suchmore » as the vertical beam size increase along the bunch train cannot be cured by the feedback system. Therefore, to achieve the NSLS-II design current of 500 mA while maintaining a small vertical beam emittance, it is important to further understand the fast ion instability and develop mitigation techniques. This paper reports on a series of ion-instability observations at various fill patterns and beam currents using start-of-art NSLS-II diagnostic tools.« less

Experimental evidence of ion-induced instabilities in the NSLS-II storage ring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, Weixing; Li, Yongjun; Podobedov, Boris

Fast ion instability has been identified as one of the most prominent instabilities in the recently constructed NSLS-II storage ring at Brookhaven National Laboratory. At a relatively low beam current (~ 25 mA) multi-bunch fills, ion-induced instabilities have already been observed during the early stages of machine commissioning. At present user operation with 250 mA in ~1000 bunches, the fast ion still remains the dominant instability, even after months of vacuum conditioning at high current. Ion-induced dipole motions of the electron beam have been suppressed using the transverse bunch-by-bunch (BxB) feedback system. However other adverse effects of this instability, suchmore » as the vertical beam size increase along the bunch train cannot be cured by the feedback system. Therefore, to achieve the NSLS-II design current of 500 mA while maintaining a small vertical beam emittance, it is important to further understand the fast ion instability and develop mitigation techniques. This paper reports on a series of ion-instability observations at various fill patterns and beam currents using start-of-art NSLS-II diagnostic tools.« less

Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer.

PubMed

Lei, Yu; Xie, Yuying; Tan, Yee Sun; Prince, Mark E; Moyer, Jeffrey S; Nör, Jacques; Wolf, Gregory T

2016-10-01

Evidence gleaned from recent studies on the role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is not only a genetic disease but also an immunologic disease. Head and Neck Squamous Cell Carcinoma (HNSCC) has been a significant model to study cancer cell-immune cell interactions. First, immune cell infiltration is an important feature of these tumors. Second, HNSCC frequently develops resistance to immunogenic cytotoxicity, which provides a window to decipher how tumors engage the immune system to establish immune tolerance. Finally, chemoradiation therapy, as a central modality for HNSCC treatment, has been shown to elicit immune activation. The presence of effector immune cells in the tumor microenvironment is often associated with superior clinical response to adjuvant therapy. On the other hand, an activated immune system, in addition to limiting tumor initiation and progression, could also exert selective pressure to promote the growth of less immunogenic tumors, as a pivotal immunoediting process. But it remains unclear how cancer cell signaling regulates tumor immunogenicity and how to mitigate HNSCC-potentiated TIL suppression. In this review, we will revisit the prognostic role of TILs in HNSCC, and collectively discuss how cancer cell machinery impacts upon the plasticity of TILs. Copyright © 2016 Elsevier Ltd. All rights reserved.

FOLLOW-UP DURABILITY MEASUREMENTS AND MITIGATION PERFORMANCE IMPROVEMENT TESTS IN 38 EASTERN PENNSYL- VANIA HOUSES HAVING INDOOR REDUCTION SYSTEMS

EPA Science Inventory

The report gives results of follow-up tests in 38 difficult- to-mitigate Pennsylvania houses where indoor radon reduction systems had been installed 2 to 4 years earlier. bjectives were to assess system durability, methods for improving performance, and methods for reducing insta...

Physics of the interaction between runaway electrons and the background plasma of the current quench in tokamak disruptions

NASA Astrophysics Data System (ADS)

Reux, Cedric

2017-10-01

Runaway electrons are created during disruptions of tokamak plasmas. They can be accelerated in the form of a multi-MA beam at energies up to several 10's of MeV. Prevention or suppression of runaway electrons during disruptions will be essential to ensure a reliable operation of future tokamaks such as ITER. Recent experiments showed that the suppression of an already accelerated beam with massive gas injection was unsuccessful at JET, conversely to smaller tokamaks. This was attributed to a dense, cold background plasma (up to several 1020 m-3 accompanying the runaway beam. The present contribution reports on the latest experimental results obtained at JET showing that some mitigation efficiency can be restored by changing the features of the background plasma. The density, temperature, position of the plasma and the energy of runaways were characterized using a combined analysis of interferometry, soft X-rays, bolometry, magnetics and hard X-rays. It showed that lower density background plasmas were obtained using smaller amounts of gas to trigger the disruption, leading to an improved penetration of the mitigation gas. Based on the observations, a physical model of the creation of the background plasma and its subsequent evolution is proposed. The plasma characteristics during later stages of the disruption are indeed dependent on the way it was initially created. The sustainment of the plasma during the runaway beam phase is then addressed by making a power balance between ohmic heating, power transfer from runaway electrons, radiation and atomic processes. Finally, a model of the interaction of the plasma with the mitigation gas is proposed to explain why massive gas injection of runaway beams works only in specific situations. This aims at pointing out which parameters bear the most importance if this mitigation scheme is to be used on larger devices like ITER. Acknowledgement: This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 under grant agreement No 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission. C. Reux, S. Jachmich, E. Joffrin, I. Coffey, O. Ficker, S. Gerasimov, V. Kiptily, U. Kruezi, M. Lehnen, U. Losada, A. Martin, J. Mlynar, E. Nardon, M. O'Mullane, V. Plyusnin, V. Riccardo, F. Saint-Laurent, G. Szepesi, S. Silburn and JET contributors.

Threat driven modeling framework using petri nets for e-learning system.

PubMed

Khamparia, Aditya; Pandey, Babita

2016-01-01

Vulnerabilities at various levels are main cause of security risks in e-learning system. This paper presents a modified threat driven modeling framework, to identify the threats after risk assessment which requires mitigation and how to mitigate those threats. To model those threat mitigations aspects oriented stochastic petri nets are used. This paper included security metrics based on vulnerabilities present in e-learning system. The Common Vulnerability Scoring System designed to provide a normalized method for rating vulnerabilities which will be used as basis in metric definitions and calculations. A case study has been also proposed which shows the need and feasibility of using aspect oriented stochastic petri net models for threat modeling which improves reliability, consistency and robustness of the e-learning system.

Development and Flight Test of an Active Flutter Suppression System for the F-4F with Stores. Part I. Design of the Active Flutter Suppression System.

DTIC Science & Technology

1982-09-01

of the wing-pylon-store changed considerably with excitation amplitude due to free play and preload. The active flutter suppression system worked well and provided an increase in flutter speed. (Author)

33 CFR 149.416 - What are the requirements for a dry chemical fire suppression system?

Code of Federal Regulations, 2010 CFR

2010-07-01

... the requirements for a dry chemical fire suppression system? Each natural gas deepwater port must be... dry chemical fire suppression system? 149.416 Section 149.416 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: DESIGN, CONSTRUCTION...

Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice.

PubMed

Nakajima, Mayuka; Arimatsu, Kei; Minagawa, Takayoshi; Matsuda, Yumi; Sato, Keisuke; Takahashi, Naoki; Nakajima, Takako; Yamazaki, Kazuhisa

2016-08-30

Periodontitis has been implicated as a risk factor for metabolic disorders associated with insulin resistance. Recently, we have demonstrated that orally administered Porphyromonas gingivalis, a representative periodontopathic bacterium, induces endotoxemia via reduced gut barrier function coupled with changes in gut microbiota composition, resulting in systemic inflammation and insulin resistance. Propolis, a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants, can positively affect metabolic disorders in various experimental models. In this study, we thus aimed to clarify the effect of propolis on impaired glucose and lipid metabolism induced by P. gingivalis administration. Eight-week-old male C57BL/6 mice were orally administered P. gingivalis strain W83, propolis ethanol extract powder with P. gingivalis, or vehicle. We then analyzed the expression profile of glucose and lipid metabolism-related genes in the liver and adipose tissues. Serum endotoxin levels were also evaluated by a limulus amebocyte lysate test. In addition, we performed histological analysis of the liver and quantified alveolar bone loss by measuring the root surface area on the lower first molar. Oral administration of P. gingivalis induced downregulation of genes that improve insulin sensitivity in adipose tissue (C1qtnf9, Irs1, and Sirt1), but upregulation of genes associated with lipid droplet formation and gluconeogenesis (Plin2, Acox, and G6pc). However, concomitant administration of propolis abrogated these adverse effects of P. gingivalis. Consistent with gene expression, histological analysis showed that administered propolis suppressed hepatic steatosis induced by P. gingivalis. Furthermore, propolis inhibited the elevation of serum endotoxin levels induced by P. gingivalis administration. Contrary to the systemic effects, propolis had no beneficial effect on alveolar bone loss. These results suggest that administration of propolis may be effective in suppressing periodontopathic bacteria-induced metabolic changes that increase the risk of various systemic diseases.

Alternative Fuels Data Center: Propane Related Links

Science.gov Websites

Amerex Corporation's Vehicle Fire Suppression Systems are designed to warn the vehicle operator and suppress the fire, protecting both equipment and employees. Automatic systems suppress the fire in its

Method to prevent/mitigate steam explosions in casting pits

DOEpatents

Taleyarkhan, Rusi P.

1996-01-01

Steam explosions can be prevented or mitigated during a metal casting process by the placement of a perforated flooring system in the casting pit. An upward flow of compressed gas through this perforated flooring system is introduced during the casting process to produce a buffer layer between any spilled molten metal and the cooling water in the reservoir. This buffer layer provides a hydrodynamic layer which acts to prevent or mitigate steam explosions resulting from hot, molten metal being spilled into or onto the cooling water.

Great East Japan earthquake, JR East mitigation successes, and lessons for California high-speed rail.

DOT National Transportation Integrated Search

2015-04-01

California and Japan both experience frequent seismic activity, which is often damaging to infrastructure. Seismologists have : developed systems for detecting and analyzing earthquakes in real-time. JR East has developed systems to mitigate the : da...

Susceptibility of SCADA systems and the energy sector

NASA Astrophysics Data System (ADS)

Goike, Lindsay

The research in this paper focused on analyzing SCADA systems in the energy sector for susceptibility to cyber attacks, in furtherance of providing suggestions to mitigate current and future cyber attacks. The research will be addressing the questions: how are SCADA systems susceptible to cyber attacks, and what are the suggested ways to mitigate both current and future cyber attacks. The five main categories of security vulnerabilities facing current SCADA systems were found to be: connectivity to the Internet, failure to plan, interdependency of sectors, numerous different types of threats, and outdated software. Some of the recommendations mentioned to mitigate current and future risks were: virtual private networks, risk assessments, increased physical security, updating of software, and firewalls.

α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction.

PubMed

Wang, Jingjing; Sun, Zhen; Gou, Wenyu; Adams, David B; Cui, Wanxing; Morgan, Katherine A; Strange, Charlie; Wang, Hongjun

2017-04-01

Islet cell transplantation has limited effectiveness because of an instant blood-mediated inflammatory reaction (IBMIR) that occurs immediately after cell infusion and leads to dramatic β-cell death. In intraportal islet transplantation models using mouse and human islets, we demonstrated that α-1 antitrypsin (AAT; Prolastin-C), a serine protease inhibitor used for the treatment of AAT deficiency, inhibits IBMIR and cytokine-induced inflammation in islets. In mice, more diabetic recipients reached normoglycemia after intraportal islet transplantation when they were treated with AAT compared with mice treated with saline. AAT suppressed blood-mediated coagulation pathways by diminishing tissue factor production, reducing plasma thrombin-antithrombin complex levels and fibrinogen deposition on islet grafts, which correlated with less graft damage and apoptosis. AAT-treated mice showed reduced serum tumor necrosis factor-α levels, decreased lymphocytic infiltration, and decreased nuclear factor (NF)-κB activation compared with controls. The potent anti-inflammatory effect of AAT is possibly mediated by suppression of c-Jun N-terminal kinase (JNK) phosphorylation. Blocking JNK activation failed to further reduce cytokine-induced apoptosis in β-cells. Taken together, AAT significantly improves islet graft survival after intraportal islet transplantation by mitigation of coagulation in IBMIR and suppression of cytokine-induced JNK and NF-κB activation. AAT-based therapy has the potential to improve graft survival in human islet transplantation and other cellular therapies on the horizon. © 2017 by the American Diabetes Association.

Space Debris Mitigation CONOPS Development

DTIC Science & Technology

2013-06-01

SPACE DEBRIS MITIGATION CONOPS DEVELOPMENT THESIS Earl B. Alejandro, Capt, USAF AFIT-ENV-13-J...04DL SPACE DEBRIS MITIGATION CONOPS DEVELOPMENT THESIS Presented to the Faculty Department of Systems Engineering and Management...June 2013 DISTRIBUTION STATEMENT A APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED AFIT-ENV-13-J-04DL SPACE DEBRIS

12 CFR 222.90 - Duties regarding the detection, prevention, and mitigation of identity theft.

Code of Federal Regulations, 2013 CFR

2013-01-01

... mitigation of identity theft. 222.90 Section 222.90 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED...) Identity Theft Red Flags § 222.90 Duties regarding the detection, prevention, and mitigation of identity... soundness of the financial institution or creditor from identity theft, including financial, operational...

12 CFR 222.90 - Duties regarding the detection, prevention, and mitigation of identity theft.

Code of Federal Regulations, 2014 CFR

2014-01-01

... mitigation of identity theft. 222.90 Section 222.90 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED...) Identity Theft Red Flags § 222.90 Duties regarding the detection, prevention, and mitigation of identity... soundness of the financial institution or creditor from identity theft, including financial, operational...

Connection between plasma response and resonant magnetic perturbation (RMP) edge localized mode (ELM) suppression in DIII-D [Connection between plasma response and RMP ELM suppression in DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wingen, Andreas; Ferraro, Nathaniel M.; Shafer, Morgan W.

Calculations of the plasma response to applied non-axisymmetric fields in several DIII-D discharges show that predicted displacements depend strongly on the edge current density. This result is found using both a linear two-fluid-MHD model (M3D-C1) and a nonlinear ideal-MHD model (VMEC). Furthermore, it is observed that the probability of a discharge being edge localized mode (ELM)-suppressed is most closely related to the edge current density, as opposed to the pressure gradient. It is found that discharges with a stronger kink response are closer to the peeling–ballooning stability limit in ELITE simulations and eventually cross into the unstable region, causing ELMsmore » to reappear. Thus for effective ELM suppression, the RMP has to prevent the plasma from generating a large kink response, associated with ELM instability. Experimental observations are in agreement with the finding; discharges which have a strong kink response in the MHD simulations show ELMs or ELM mitigation during the RMP phase of the experiment, while discharges with a small kink response in the MHD simulations are fully ELM suppressed in the experiment by the applied resonant magnetic perturbation. The results are cross-checked against modeled 3D ideal MHD equilibria using the VMEC code. The procedure of constructing optimal 3D equilibria for diverted H-mode discharges using VMEC is presented. As a result, kink displacements in VMEC are found to scale with the edge current density, similar to M3D-C1, but the displacements are smaller. A direct correlation in the flux surface displacements to the bootstrap current is shown.« less

Connection between plasma response and resonant magnetic perturbation (RMP) edge localized mode (ELM) suppression in DIII-D [Connection between plasma response and RMP ELM suppression in DIII-D

DOE PAGES

Wingen, Andreas; Ferraro, Nathaniel M.; Shafer, Morgan W.; ...

2015-09-03

Calculations of the plasma response to applied non-axisymmetric fields in several DIII-D discharges show that predicted displacements depend strongly on the edge current density. This result is found using both a linear two-fluid-MHD model (M3D-C1) and a nonlinear ideal-MHD model (VMEC). Furthermore, it is observed that the probability of a discharge being edge localized mode (ELM)-suppressed is most closely related to the edge current density, as opposed to the pressure gradient. It is found that discharges with a stronger kink response are closer to the peeling–ballooning stability limit in ELITE simulations and eventually cross into the unstable region, causing ELMsmore » to reappear. Thus for effective ELM suppression, the RMP has to prevent the plasma from generating a large kink response, associated with ELM instability. Experimental observations are in agreement with the finding; discharges which have a strong kink response in the MHD simulations show ELMs or ELM mitigation during the RMP phase of the experiment, while discharges with a small kink response in the MHD simulations are fully ELM suppressed in the experiment by the applied resonant magnetic perturbation. The results are cross-checked against modeled 3D ideal MHD equilibria using the VMEC code. The procedure of constructing optimal 3D equilibria for diverted H-mode discharges using VMEC is presented. As a result, kink displacements in VMEC are found to scale with the edge current density, similar to M3D-C1, but the displacements are smaller. A direct correlation in the flux surface displacements to the bootstrap current is shown.« less

Estrogen receptor antagonism uncovers gender-dimorphic suppression of whole body fat oxidation in humans: differential effects of tamoxifen on the GH and gonadal axes.

PubMed

Birzniece, Vita; Ho, Ken K Y

2015-10-01

Tamoxifen, a selective estrogen receptor modulator, suppresses GH secretion in women but not in men. It increases testosterone levels in men. As GH and testosterone stimulate fat metabolism, the metabolic consequences of tamoxifen may be greater in women than in men. To determine whether tamoxifen suppresses fat oxidation (Fox) to a greater degree in women than in men. An open-label study of ten healthy postmenopausal women and ten healthy men receiving 2-week treatment with tamoxifen (20  mg/day). GH response to arginine stimulation, serum levels of IGF1, testosterone and LH (men only), sex hormone binding globulin (SHBG) and whole body basal and postprandial Fox. In women, tamoxifen significantly reduced the mean GH response to arginine stimulation (Δ -87%, P<0.05) and circulating IGF1 levels (Δ -23.5±5.4%, P<0.01). Tamoxifen reduced postprandial Fox in women (Δ -34.6±10.3%; P<0.05). In men, tamoxifen did not affect the GH response to arginine stimulation but significantly reduced mean IGF1 levels (Δ -24.8±6.1%, P<0.01). Tamoxifen increased mean testosterone levels (Δ 52±14.2%; P<0.01). Fox was not significantly affected by tamoxifen in men. Tamoxifen attenuated the GH response to stimulation and reduced postprandial Fox in women but not in men. We conclude that at a therapeutic dose, the suppressive effect of tamoxifen on fat metabolism is gender-dependent. Higher testosterone levels may mitigate the suppression of GH secretion and Fox during tamoxifen treatment in men. © 2015 European Society of Endocrinology.

MOTOR CORTICAL PLASTICITY IN EXTRINSIC HAND MUSCLES IS DETERMINED BY THE RESTING THRESHOLDS OF OVERLAPPING REPRESENTATIONS

PubMed Central

MIRDAMADI, J. L.; SUZUKI, L. Y.; MEEHAN, S. K.

2018-01-01

Knowledge of the properties that govern the effectiveness of transcranial magnetic stimulation (TMS) interventions is critical to clinical application. Extrapolation to clinical populations has been limited by high inter-subject variability and a focus on intrinsic muscles of the hand in healthy populations. Therefore, the current study assessed variability of continuous theta burst stimulation (cTBS), a patterned TMS protocol, across an agonist–antagonist pair of extrinsic muscles of the hand. Secondarily, we assessed whether concurrent agonist contraction could enhance the efficacy of cTBS. Motor evoked potentials (MEP) were simultaneously recorded from the agonist flexor (FCR) and antagonist extensor (ECR) carpi radialis before and after cTBS over the FCR hotspot. cTBS was delivered with the FCR relaxed (cTBS-Relax) or during isometric wrist flexion (cTBS-Contract). cTBS-Relax suppressed FCR MEPs evoked from the FCR hotspot. However, the extent of FCR MEP suppression was strongly correlated with the relative difference between FCR and ECR resting motor thresholds. cTBS-Contract decreased FCR suppression but increased suppression of ECR MEPs elicited from the FCR hotspot. The magnitude of ECR MEP suppression following cTBS-Contract was independent of the threshold-amplitude relationships observed with cTBS-Relax. Contraction alone had no effect confirming the effect of cTBS-Contract was driven by the interaction between neuromuscular activity and cTBS. Interactions across muscle representations should be taken into account when predicting cTBS outcomes in healthy and clinical populations. Contraction during cTBS may be a useful means of focusing aftereffects when differences in baseline excitability across overlapping agonist–antagonist cortical representations may mitigate the inhibitory effect of cTBS. PMID:27425211

Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039).

PubMed

Willis, John; Epperly, Michael W; Fisher, Renee; Zhang, Xichen; Shields, Donna; Hou, Wen; Wang, Hong; Li, Song; Wipf, Peter; Parmar, Kalindi; Guinan, Eva; Steinman, Justin; Greenberger, Joel S

2018-06-01

Squamous cell carcinomas of the head and neck are appearing with increased frequency in both marrow transplanted and non-transplanted Fanconi anemia (FA) patients. FA patients commonly display radiosensitivity of epithelial tissues, complicating effective radiotherapy. Fancd2 -/- mice (C57BL/6J and 129/Sv background) demonstrate epithelial tissue sensitivity to single-fraction or fractionated irradiation to the head and neck and distant marrow suppression (abscopal effect), both ameliorated by intraoral administration of the mitochondrial-targeted antioxidant, GS-nitroxide, JP4-039. We now report that mice of two other FA genotypes, Fancg -/- (B6) and the most prevalent human genotype Fanca -/- (129/Sv), also demonstrate: 1. reduced longevity of hematopoiesis in long-term bone marrow cultures; 2. radiosensitivity of bone marrow stromal cell lines; and 3. head and neck radiation-induced severe mucositis and abscopal suppression of distant marrow hematopoiesis. Intraoral administration of JP4-039/F15, but not non-mitochondrial-targeted 4-amino-Tempo/F15 or F15 alone, prior to each radiation treatment ameliorated both local and abscopal radiation effects. Head and neck irradiated TGF-β-resistant SMAD3 -/- (129/Sv) mice and double-knockout SMAD3 -/- Fancd2 -/- (129/Sv) mice treated daily with TGF-β receptor antagonist, LY364947, still displayed abscopal bone marrow suppression, implicating a non-TGF-β mechanism. Thus, amelioration of both local normal tissue radiosensitivity and distant marrow suppression by intraoral administration of JP4-039 in Fancg -/- and Fanca -/- mice supports a clinical trial of this locally administered normal tissue radioprotector and mitigator during head and neck irradiation in FA patients.

Detecting and mitigating wind turbine clutter for airspace radar systems.

PubMed

Wang, Wen-Qin

2013-01-01

It is well recognized that a wind turbine has a large radar cross-section (RCS) and, due to the movement of the blades, the wind turbine will generate a Doppler frequency shift. This scattering behavior may cause severe interferences on existing radar systems including static ground-based radars and spaceborne or airborne radars. To resolve this problem, efficient techniques or algorithms should be developed to mitigate the effects of wind farms on radars. Herein, one transponder-based mitigation technique is presented. The transponder is not a new concept, which has been proposed for calibrating high-resolution imaging radars. It modulates the radar signal in a manner that the retransmitted signals can be separated from the scene echoes. As wind farms often occupy only a small area, mitigation processing in the whole radar operation will be redundant and cost inefficient. Hence, this paper uses a transponder to determine whether the radar is impacted by the wind farms. If so, the effects of wind farms are then mitigated with subsequent Kalman filtering or plot target extraction algorithms. Taking airborne synthetic aperture radar (SAR) and pulse Doppler radar as the examples, this paper provides the corresponding system configuration and processing algorithms. The effectiveness of the mitigation technique is validated by numerical simulation results.

Detecting and Mitigating Wind Turbine Clutter for Airspace Radar Systems

PubMed Central

2013-01-01

It is well recognized that a wind turbine has a large radar cross-section (RCS) and, due to the movement of the blades, the wind turbine will generate a Doppler frequency shift. This scattering behavior may cause severe interferences on existing radar systems including static ground-based radars and spaceborne or airborne radars. To resolve this problem, efficient techniques or algorithms should be developed to mitigate the effects of wind farms on radars. Herein, one transponder-based mitigation technique is presented. The transponder is not a new concept, which has been proposed for calibrating high-resolution imaging radars. It modulates the radar signal in a manner that the retransmitted signals can be separated from the scene echoes. As wind farms often occupy only a small area, mitigation processing in the whole radar operation will be redundant and cost inefficient. Hence, this paper uses a transponder to determine whether the radar is impacted by the wind farms. If so, the effects of wind farms are then mitigated with subsequent Kalman filtering or plot target extraction algorithms. Taking airborne synthetic aperture radar (SAR) and pulse Doppler radar as the examples, this paper provides the corresponding system configuration and processing algorithms. The effectiveness of the mitigation technique is validated by numerical simulation results. PMID:24385880

A closed-loop anesthetic delivery system for real-time control of burst suppression

NASA Astrophysics Data System (ADS)

Liberman, Max Y.; Ching, ShiNung; Chemali, Jessica; Brown, Emery N.

2013-08-01

Objective. There is growing interest in using closed-loop anesthetic delivery (CLAD) systems to automate control of brain states (sedation, unconsciousness and antinociception) in patients receiving anesthesia care. The accuracy and reliability of these systems can be improved by using as control signals electroencephalogram (EEG) markers for which the neurophysiological links to the anesthetic-induced brain states are well established. Burst suppression, in which bursts of electrical activity alternate with periods of quiescence or suppression, is a well-known, readily discernible EEG marker of profound brain inactivation and unconsciousness. This pattern is commonly maintained when anesthetics are administered to produce a medically-induced coma for cerebral protection in patients suffering from brain injuries or to arrest brain activity in patients having uncontrollable seizures. Although the coma may be required for several hours or days, drug infusion rates are managed inefficiently by manual adjustment. Our objective is to design a CLAD system for burst suppression control to automate management of medically-induced coma. Approach. We establish a CLAD system to control burst suppression consisting of: a two-dimensional linear system model relating the anesthetic brain level to the EEG dynamics; a new control signal, the burst suppression probability (BSP) defining the instantaneous probability of suppression; the BSP filter, a state-space algorithm to estimate the BSP from EEG recordings; a proportional-integral controller; and a system identification procedure to estimate the model and controller parameters. Main results. We demonstrate reliable performance of our system in simulation studies of burst suppression control using both propofol and etomidate in rodent experiments based on Vijn and Sneyd, and in human experiments based on the Schnider pharmacokinetic model for propofol. Using propofol, we further demonstrate that our control system reliably tracks changing target levels of burst suppression in simulated human subjects across different epidemiological profiles. Significance. Our results give new insights into CLAD system design and suggest a control-theory framework to automate second-to-second control of burst suppression for management of medically-induced coma.

Whole-farm models to quantify greenhouse gas emissions and their potential use for linking climate change mitigation and adaptation in temperate grassland ruminant-based farming systems.

PubMed

Del Prado, A; Crosson, P; Olesen, J E; Rotz, C A

2013-06-01

The farm level is the most appropriate scale for evaluating options for mitigating greenhouse gas (GHG) emissions, because the farm represents the unit at which management decisions in livestock production are made. To date, a number of whole farm modelling approaches have been developed to quantify GHG emissions and explore climate change mitigation strategies for livestock systems. This paper analyses the limitations and strengths of the different existing approaches for modelling GHG mitigation by considering basic model structures, approaches for simulating GHG emissions from various farm components and the sensitivity of GHG outputs and mitigation measures to different approaches. Potential challenges for linking existing models with the simulation of impacts and adaptation measures under climate change are explored along with a brief discussion of the effects on other ecosystem services.

INFLUENCES OF HVAC DESIGN AND OPERATION ON RADON MITIGATION OF EXISTING SCHOOL BUILDINGS

EPA Science Inventory

The paper discusses various school building characteristics identified as influencing radon entry, the design and operation of installed mitigation systems in four Maryland schools, and the success of these systems in reducing school radon levels. Several public school buildings ...

Performance evaluation of a semi-active cladding connection for multi-hazard mitigation

NASA Astrophysics Data System (ADS)

Gong, Yongqiang; Cao, Liang; Micheli, Laura; Laflamme, Simon; Quiel, Spencer; Ricles, James

2018-03-01

A novel semi-active damping device termed Variable Friction Cladding Connection (VFCC) has been previously proposed to leverage cladding systems for the mitigation of natural and man-made hazards. The VFCC is a semi-active friction damper that connects cladding elements to the structural system. The friction force is generated by sliding plates and varied using an actuator through a system of adjustable toggles. The dynamics of the device has been previously characterized in a laboratory environment. In this paper, the performance of the VFCC at mitigating non-simultaneous multi-hazard excitations that includes wind and seismic loads is investigated on a simulated benchmark building. Simulations consider the robustness with respect to some uncertainties, including the wear of the friction surfaces and sensor failure. The performance of the VFCC is compared against other connection strategies including traditional stiffness, passive viscous, and passive friction elements. Results show that the VFCC is robust and capable of outperforming passive systems for the mitigation of multiple hazards.

Strategies to mitigate nitrous oxide emissions from herbivore production systems.

PubMed

Schils, R L M; Eriksen, J; Ledgard, S F; Vellinga, Th V; Kuikman, P J; Luo, J; Petersen, S O; Velthof, G L

2013-03-01

Herbivores are a significant source of nitrous oxide (N(2)O) emissions. They account for a large share of manure-related N(2)O emissions, as well as soil-related N(2)O emissions through the use of grazing land, and land for feed and forage production. It is widely acknowledged that mitigation measures are necessary to avoid an increase in N(2)O emissions while meeting the growing global food demand. The production and emissions of N(2)O are closely linked to the efficiency of nitrogen (N) transfer between the major components of a livestock system, that is, animal, manure, soil and crop. Therefore, mitigation options in this paper have been structured along these N pathways. Mitigation technologies involving diet-based intervention include lowering the CP content or increasing the condensed tannin content of the diet. Animal-related mitigation options also include breeding for improved N conversion and high animal productivity. The main soil-based mitigation measures include efficient use of fertilizer and manure, including the use of nitrification inhibitors. In pasture-based systems with animal housing facilities, reducing grazing time is an effective option to reduce N(2)O losses. Crop-based options comprise breeding efforts for increased N-use efficiency and the use of pastures with N(2)-fixing clover. It is important to recognize that all N(2)O mitigation options affect the N and carbon cycles of livestock systems. Therefore, care should be taken that reductions in N(2)O emissions are not offset by unwanted increases in ammonia, methane or carbon dioxide emissions. Despite the abundant availability of mitigation options, implementation in practice is still lagging. Actual implementation will only follow after increased awareness among farmers and greenhouse gases targeted policies. So far, reductions in N(2)O emissions that have been achieved are mostly a positive side effect of other N-targeted policies.

Modeling of high-Z materials erosion and its suppression in DIII-D

NASA Astrophysics Data System (ADS)

Ding, Rui; Guo, H. Y.; Chan, V. S.; Snyder, P. B.; Rudakov, D. L.; Stangeby, P. C.; Elder, J. D.; Tskhakaya, D.; Wampler, W. R.; Kirschner, A.; McLean, A. G.

2015-11-01

Erosion of plasma facing components is a key issue for high-power, long pulse operation. The 3D Monte Carlo code ERO has been used to simulate the erosion/redeposition of Mo and W samples exposed to DIII-D divertor plasma using the DiMES. The net erosion rate is significantly reduced due to the high local re-deposition ratio of eroded materials, which is mainly controlled by the electric field and plasma density within the Chodura sheath as indicated by ERO modeling. Similar re-deposition ratios were obtained from the modeling using three sheath models for small inclined magnetic field angle, all being close to the measured value. ERO modeling shows that local CH4 injection can create a carbon coating on the Mo sample to mitigate Mo erosion; the local decrease of electron temperature due to gas injection also suppresses net erosion, consistent with experimental observation. Supported by the US DOE under DE-FC02-04ER54698 and PSI-SciDAC project.

Precise calibration of spatial phase response nonuniformity arising in liquid crystal on silicon.

PubMed

Xu, Jingquan; Qin, SiYi; Liu, Chen; Fu, Songnian; Liu, Deming

2018-06-15

In order to calibrate the spatial phase response nonuniformity of liquid crystal on silicon (LCoS), we propose to use a Twyman-Green interferometer to characterize the wavefront distortion, due to the inherent curvature of the device. During the characterization, both the residual carrier frequency introduced by the Fourier transform evaluation method and the lens aberration are error sources. For the tilted phase error introduced by residual carrier frequency, the least mean square fitting method is used to obtain the tilted phase error. Meanwhile, we use Zernike polynomials fitting based on plane mirror calibration to mitigate the lens aberration. For a typical LCoS with 1×12,288 pixels after calibration, the peak-to-valley value of the inherent wavefront distortion is approximately 0.25λ at 1550 nm, leading to a half-suppression of wavefront distortion. All efforts can suppress the root mean squares value of the inherent wavefront distortion to approximately λ/34.

Mannitol can mitigate negative effects of simulated acid mist and fluoranthene in juvenile Japanese red pine (P. densiflora Sieb. et Zucc.).

PubMed

Oguntimehin, Ilemobayo; Bandai, Sayuri; Sakugawa, Hiroshi

2013-03-01

The negative health effects of simulated acid mists and fluoranthene on juvenile Japanese red pine were investigated, and the methods of protection from these pollutants were examined. The needle gas exchange, chlorophyll fluorescence, chemical contents and visual damage to needles caused by acid mist applied alone or its conjunction with fluoranthene were investigated over 60 d and 20 d, respectively. Acid mist at pH 2 and 3 caused physiological and visual damage, which was enhanced by the addition of fluoranthene to the mist. However, fluoranthene and acid mist at pH 4 and 5 showed only minor effects. These findings indicate that acid mist may be more harmful to pine trees if it occurs in conjunction with polycyclic aromatic hydrocarbons. Moreover, suppression of the singular and additive effects of these compounds was achieved using mannitol, which may be widely applicable to suppression of reactive oxygen species-mediated plant damage. Copyright © 2012 Elsevier Ltd. All rights reserved.

Mincle suppresses Toll-like receptor 4 activation.

PubMed

Greco, Stephanie H; Mahmood, Syed Kashif; Vahle, Anne-Kristin; Ochi, Atsuo; Batel, Jennifer; Deutsch, Michael; Barilla, Rocky; Seifert, Lena; Pachter, H Leon; Daley, Donnele; Torres-Hernandez, Alejandro; Hundeyin, Mautin; Mani, Vishnu R; Miller, George

2016-07-01

Regulation of Toll-like receptor responses is critical for limiting tissue injury and autoimmunity in both sepsis and sterile inflammation. We found that Mincle, a C-type lectin receptor, regulates proinflammatory Toll-like receptor 4 signaling. Specifically, Mincle ligation diminishes Toll-like receptor 4-mediated inflammation, whereas Mincle deletion or knockdown results in marked hyperresponsiveness to lipopolysaccharide in vitro, as well as overwhelming lipopolysaccharide-mediated inflammation in vivo. Mechanistically, Mincle deletion does not up-regulate Toll-like receptor 4 expression or reduce interleukin 10 production after Toll-like receptor 4 ligation; however, Mincle deletion decreases production of the p38 mitogen-activated protein kinase-dependent inhibitory intermediate suppressor of cytokine signaling 1, A20, and ABIN3 and increases expression of the Toll-like receptor 4 coreceptor CD14. Blockade of CD14 mitigates the increased sensitivity of Mincle(-/-) leukocytes to Toll-like receptor 4 ligation. Collectively, we describe a major role for Mincle in suppressing Toll-like receptor 4 responses and implicate its importance in nonmycobacterial models of inflammation. © Society for Leukocyte Biology.

Introduction to the effects of wildland fire on aquatic ecosystems in the Western USA

USGS Publications Warehouse

Rieman, B.; Gresswell, Robert E.; Young, M.; Luce, C.

2003-01-01

The management of wildfire has long been controversial. The role of fire and fire-related management in terrestrial and aquatic ecosystems has become an important focus in recent years, but the general debate is not new. In his recent book, Stephen Pyne (2001 )describes the political and scientific debate surrounding the creation of the U.S. Forest Service and the emergence of fire suppression as a central tenet of wildland management. Essentially, views in the first decade of the 20th century focused on fire as good or evil: a tool that might benefit other resources or interests (e.g. Indian burning) and mitigate larger more destructive fires, or a threat to the recruitment and productivity of newly designated forest reserves. The “great fires” in the Western USA in 1910 and the associated loss of human life and property largely forged the public and political will to suppress fire on a massive scale.

Development and Flight Test of an Active Flutter Suppression System for the F-4F with Stores. Part 3. Flight Demonstration of the Active Flutter Suppression System.

DTIC Science & Technology

1983-06-01

that the dynamic behavior of the wing-pylon-store changed considerably with excitation amplitude due to free play and preload. The active flutter suppression system worked well and provided an increase in flutter speed.

Human Factors in Field Experimentation Design and Analysis of Analytical Suppression Model

DTIC Science & Technology

1978-09-01

men in uf"an-dachine- Systems " supports the development of new doctrines, design of weapon systems as well as training programs for trQops. One...Experimentation Design -Master’s thesis: and Analysis.of an Analytical Suppression.Spebr17 Model PR@~w 3.RPR 7. AUTHOR(@) COT RIETeo 31AN? wijMu~aw...influences to suppression. Techniques are examined for including. the suppre.ssive effects of weapon systems in Lanchester-type combat m~odels, whir~h may be

Assessing CO2 Mitigation Options Utilizing Detailed Electricity Characteristics and Including Renewable Generation

NASA Astrophysics Data System (ADS)

Bensaida, K.; Alie, Colin; Elkamel, A.; Almansoori, A.

2017-08-01

This paper presents a novel techno-economic optimization model for assessing the effectiveness of CO2 mitigation options for the electricity generation sub-sector that includes renewable energy generation. The optimization problem was formulated as a MINLP model using the GAMS modeling system. The model seeks the minimization of the power generation costs under CO2 emission constraints by dispatching power from low CO2 emission-intensity units. The model considers the detailed operation of the electricity system to effectively assess the performance of GHG mitigation strategies and integrates load balancing, carbon capture and carbon taxes as methods for reducing CO2 emissions. Two case studies are discussed to analyze the benefits and challenges of the CO2 reduction methods in the electricity system. The proposed mitigations options would not only benefit the environment, but they will as well improve the marginal cost of producing energy which represents an advantage for stakeholders.

Damage-mitigating control of aerospace systems for high performance and extended life

NASA Technical Reports Server (NTRS)

Ray, Asok; Wu, Min-Kuang; Carpino, Marc; Lorenzo, Carl F.; Merrill, Walter C.

1992-01-01

The concept of damage-mitigating control is to minimize fatigue (as well as creep and corrosion) damage of critical components of mechanical structures while simultaneously maximizing the system dynamic performance. Given a dynamic model of the plant and the specifications for performance and stability robustness, the task is to synthesize a control law that would meet the system requirements and, at the same time, satisfy the constraints that are imposed by the material and structural properties of the critical components. The authors present the concept of damage-mitigating control systems design with the following objectives: (1) to achieve high performance with a prolonged life span; and (2) to systematically update the controller as the new technology of advanced materials evolves. The major challenge is to extract the information from the material properties and then utilize this information in a mathematical form so that it can be directly applied to robust control synthesis for mechanical systems. The basic concept of damage-mitigating control is illustrated using a relatively simplified model of a space shuttle main engine.

Interference Mitigation Effects on Synthetic Aperture Radar Coherent Data Products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Musgrove, Cameron

2014-05-01

For synthetic aperture radar image products interference can degrade the quality of the images while techniques to mitigate the interference also reduce the image quality. Usually the radar system designer will try to balance the amount of mitigation for the amount of interference to optimize the image quality. This may work well for many situations, but coherent data products derived from the image products are more sensitive than the human eye to distortions caused by interference and mitigation of interference. This dissertation examines the e ect that interference and mitigation of interference has upon coherent data products. An improvement tomore » the standard notch mitigation is introduced, called the equalization notch. Other methods are suggested to mitigation interference while improving the quality of coherent data products over existing methods.« less

Damage-mitigating control of space propulsion systems for high performance and extended life

NASA Technical Reports Server (NTRS)

Ray, Asok; Wu, Min-Kuang; Dai, Xiaowen; Carpino, Marc; Lorenzo, Carl F.

1993-01-01

Calculations are presented showing that a substantial improvement in service life of a reusable rocket engine can be achieved by an insignificant reduction in the system dynamic performance. The paper introduces the concept of damage mitigation and formulates a continuous-time model of fatigue damage dynamics. For control of complex mechanical systems, damage prediction and damage mitigation are carried out based on the available sensory and operational information such that the plant can be inexpensively maintained and safely and efficiently steered under diverse operating conditions. The results of simulation experiments are presented for transient operations of a reusable rocket engine.

Noise Mitigation During Pile Driving Efficiently Reduces Disturbance of Marine Mammals.

PubMed

Nehls, Georg; Rose, Armin; Diederichs, Ansgar; Bellmann, Michael; Pehlke, Hendrik

2016-01-01

Acoustic monitoring of harbor porpoises (Phocoena phocoena L., 1758) indicated a strongly reduced disturbance by noise emitted by pile driving for offshore wind turbine foundations insulated by a big bubble curtain (BBC). This newly developed noise mitigation system was tested during construction of the offshore wind farm Borkum West II (North Sea). Because porpoise activity strongly corresponded to the sound level, operation of the new system under its most suitable configuration reduced the porpoise disturbance area by ~90%. Hence, for the first time, a positive effect of a noise mitigation system during offshore pile driving on an affected marine mammal species could be demonstrated.

A new topology of fuel cell hybrid power source for efficient operation and high reliability

NASA Astrophysics Data System (ADS)

Bizon, Nicu

2011-03-01

This paper analyzes a new fuel cell Hybrid Power Source (HPS) topology having the feature to mitigate the current ripple of the fuel cell inverter system. In the operation of the inverter system that is grid connected or supplies AC motors in vehicle application, the current ripple normally appears at the DC port of the fuel cell HPS. Consequently, if mitigation measures are not applied, this ripple is back propagated to the fuel cell stack. Other features of the proposed fuel cell HPS are the Maximum Power Point (MPP) tracking, high reliability in operation under sharp power pulses and improved energy efficiency in high power applications. This topology uses an inverter system directly powered from the appropriate fuel cell stack and a controlled buck current source as low power source used for ripple mitigation. The low frequency ripple mitigation is based on active control. The anti-ripple current is injected in HPS output node and this has the LF power spectrum almost the same with the inverter ripple. Consequently, the fuel cell current ripple is mitigated by the designed active control. The ripple mitigation performances are evaluated by indicators that are defined to measure the mitigation ratio of the low frequency harmonics. In this paper it is shown that good performances are obtained by using the hysteretic current control, but better if a dedicated nonlinear controller is used. Two ways to design the nonlinear control law are proposed. First is based on simulation trials that help to draw the characteristic of ripple mitigation ratio vs. fuel cell current ripple. The second is based on Fuzzy Logic Controller (FLC). The ripple factor is up to 1% in both cases.

Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.

PubMed

Clark, Amy L; Kanekura, Kohsuke; Lavagnino, Zeno; Spears, Larry D; Abreu, Damien; Mahadevan, Jana; Yagi, Takuya; Semenkovich, Clay F; Piston, David W; Urano, Fumihiko

2017-07-17

Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role in cytokine-mediated beta cell death, there are currently no treatments targeting cellular calcium homeostasis to combat type 1 diabetes. Here we show that modulation of cellular calcium homeostasis can mitigate cytokine- and ER stress-mediated beta cell death. The calcium modulating compounds, dantrolene and sitagliptin, both prevent cytokine and ER stress-induced activation of the pro-apoptotic calcium-dependent enzyme, calpain, and partly suppress beta cell death in INS1E cells and human primary islets. These agents are also able to restore cytokine-mediated suppression of functional ER calcium release. In addition, sitagliptin preserves function of the ER calcium pump, sarco-endoplasmic reticulum Ca 2+ -ATPase (SERCA), and decreases levels of the pro-apoptotic protein thioredoxin-interacting protein (TXNIP). Supporting the role of TXNIP in cytokine-mediated cell death, knock down of TXNIP in INS1-E cells prevents cytokine-mediated beta cell death. Our findings demonstrate that modulation of dynamic cellular calcium homeostasis and TXNIP suppression present viable pharmacologic targets to prevent cytokine-mediated beta cell loss in diabetes.

Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.

PubMed

Tsubaki, Masanobu; Takeda, Tomoya; Asano, Ryo-Ta; Matsuda, Tomoyuki; Fujimoto, Shin-Ichiro; Itoh, Tatsuki; Imano, Motohiro; Satou, Takao; Nishida, Shozo

2018-02-01

Oral mucositis is a common adverse effect of chemotherapy that limits the required dose of chemotherapeutic agents. Numerous attempts to mitigate chemotherapy-induced oral mucositis have failed to identify an appropriate treatment. Recently, it has been indicated that rebamipide prevents chemoradiotherapy-induced oral mucositis in patients. However, the details of the underlying mechanism involved in the cytoprotective effect of rebamipide remain obscure. In the present study, we investigated the mechanism behind rebamipide cytoprotective effect in the oral mucosa using primary normal human oral keratinocytes (NHOK cells). We found that rebamipide prevented 5-fluorouracil (5-FU)-induced cell death in NHOK cells. In addition, rebamipide increased the levels of phosphorylated Akt and mTOR, enhanced the Bcl-2 and Bcl-xL expressions, and suppressed the expression of Bax and Bim. This is in contrast to 5-FU-induced suppression of Akt and mTOR activation, Bcl-2 and Bcl-xL expressions, and the enhanced expression of Bax and Bim. These findings suggest that rebamipide can potentially be used for the protection of oral mucosa from chemotherapy-induced mucositis. This is the first study that elucidates the specific molecular pathway for the cytoprotective effect of rebamipide. Copyright © 2017 Elsevier Ltd. All rights reserved.

APPL1-mediated activation of STAT3 contributes to inhibitory effect of adiponectin on hepatic gluconeogenesis.

PubMed

Ding, Youming; Zhang, Deling; Wang, Bin; Zhang, Yemin; Wang, Lei; Chen, Xiaoyan; Li, Mingxin; Tang, Zhao; Wang, Changhua

2016-09-15

Adiponectin has been shown to suppress hepatic gluconeogenesis. However, the signaling pathways underlying its action remain ill-defined. The purpose of this study was to examine the potential role of APPL1 in mediating anti-gluconeogenic ability of adiponectin. Primary hepatocytes were isolated from male C57BL/6 mice. Western blot and RT-PCR were performed to detect protein expression and mRNA level, respectively. The protein-protein association was determined by immunoprecipitation and GST pull-down assay. We found that APPL1 protein levels were negatively associated with expressions of proteins and mRNAs of gluconeogenesis enzymes under stimulation with adiponectin. In addition, adiponectin-stimulated STAT3 phosphorylation and acetylation were positively regulated by APPL1 and negative regulated by SirT1. Pharmacological and genetic inhibition of STAT3 mitigated impact of adiponectin on hepatic gluconeogenesis. Furthermore, adiponectin administration facilitated the binding of APPL1 to SirT1 and suppressed the association of SirT1 with STAT3. Taken together, our study showed that APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes. This new finding provides a novel mechanism by which adiponectin suppresses hepatic gluconeogenesis. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

78 FR 24101 - Generator Requirements at the Transmission Interface

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... (Transmission Vegetation Management), PRC-004- 2.1a (Analysis and Mitigation of Transmission and Generation Protection System Misoperations), and PRC-005-1.1b (Transmission and Generation Protection System Maintenance... (Transmission Vegetation Management), PRC-004- 2.1a (Analysis and Mitigation of Transmission and Generation...

Assessment of Mitigation Systems on Vapor Intrusion: Temporal Trends, Attenuation Factors, and Contaminant Migration Routes under Mitigated and Non-mitigated Conditions

EPA Science Inventory

Vapor intrusion is the migration of subsurface vapors, including radon and volatile organic compounds (VOCs), in soil gas from the subsurface to indoor air. Vapor intrusion happens because there are pressure and concentration differentials between indoor air and soil gas. Indoor ...

Elevated CO2-mitigation of high temperature stress associated with maintenance of positive carbon balance and carbohydrate accumulation in Kentucky bluegrass.

PubMed

Song, Yali; Yu, Jingjin; Huang, Bingru

2014-01-01

Elevated CO2 concentration may promote plant growth while high temperature is inhibitory for C3 plant species. The interactive effects of elevated CO2 and high temperatures on C3 perennial grass growth and carbon metabolism are not well documented. Kentucky bluegrass (Poa pratensis) plants were exposed to two CO2 levels (400 and 800 μmol mol-1) and five temperatures (15/12, 20/17, 25/22, 30/27, 35/32°C, day/night) in growth chambers. Increasing temperatures to 25°C and above inhibited leaf photosynthetic rate (Pn) and shoot and root growth, but increased leaf respiration rate (R), leading to a negative carbon balance and a decline in soluble sugar content under ambient CO2. Elevated CO2 did not cause shift of optimal temperatures in Kentucky bluegrass, but promoted Pn, shoot and root growth under all levels of temperature (15, 20, 25, 30, and 35°C) and mitigated the adverse effects of severe high temperatures (30 and 35°C). Elevated CO2-mitigation of adverse effects of high temperatures on Kentucky bluegrass growth could be associated with the maintenance of a positive carbon balance and the accumulation of soluble sugars and total nonstructural carbohydrates through stimulation of Pn and suppression of R and respiratory organic acid metabolism.

Mitigation effects of silicon rich amendments on heavy metal accumulation in rice (Oryza sativa L.) planted on multi-metal contaminated acidic soil.

PubMed

Gu, Hai-Hong; Qiu, Hao; Tian, Tian; Zhan, Shu-Shun; Deng, Teng-Hao-Bo; Chaney, Rufus L; Wang, Shi-Zhong; Tang, Ye-Tao; Morel, Jean-Louis; Qiu, Rong-Liang

2011-05-01

The mechanisms of stabilization by silicon-rich amendments of cadmium, zinc, copper and lead in a multi-metal contaminated acidic soil and the mitigation of metal accumulation in rice were investigated in this study. The results from a pot experiment indicated that the application of fly ash (20 and 40gkg(-1)) and steel slag (3 and 6gkg(-1)) increased soil pH from 4.0 to 5.0-6.4, decreased the phytoavailability of heavy metals by at least 60%, and further suppressed metal uptake by rice. Diffusion gradient in thin-film measurement showed the heavy metal diffusion fluxes from soil to solution decreased by greater than 84% after remediation. X-ray diffraction analysis indicated the mobile metals were mainly deposited as their silicates, phosphates and hydroxides in amended treatments. Moreover, it was found metal translocation from stem to leaf was dramatically restrained by adding amendments, which might be due to the increase of silicon concentration and co-precipitation with heavy metals in stem. Finally, a field experiment showed the trace element concentrations in polished rice treated with amendments complied with the food safety standards of China. These results demonstrated fly ash and steel slag could be effective in mitigating heavy metal accumulation in rice grown on multi-metal contaminated acidic soils. Copyright © 2011 Elsevier Ltd. All rights reserved.

Simulation analysis of a wildfire suppression system

Treesearch

Abílio Pereira Pacheco; João Claro; Tiago Oliveira

2013-01-01

Rekindles and false alarms are unusually high in the Portuguese wildfire management system, representing a high burden on suppression resources in particular, and fire management resources in general. In 20,049 occurrences that the suppression system handled in the summer of 2010, 12.5% were false alarms and 15.0% were rekindles. We present a discreteevent simulation...

Implementation of Polyurea Applications for Wastewater System Corrosion-Mitigation Projects: Final Report on Project F15-AR04

DTIC Science & Technology

2017-07-24

Corrosion-Mitigation Projects Final Report on Project F15-AR04 Co ns tr uc tio n En gi ne er in g R es ea rc h La bo ra to ry Clint A. Wilson...2017 Implementation of Polyurea Applications for Wastewater System Corrosion-Mitigation Projects Final Report on Project F15-AR04 Clint A...Secretary of Defense Washington, DC 20301-3090 Under Project F15-AR04, “Polyurea Coating for Rehabilitation of Concrete and Metal Infrastructure

Method to prevent/mitigate steam explosions in casting pits

DOEpatents

Taleyarkhan, R.P.

1996-12-24

Steam explosions can be prevented or mitigated during a metal casting process by the placement of a perforated flooring system in the casting pit. An upward flow of compressed gas through this perforated flooring system is introduced during the casting process to produce a buffer layer between any spilled molten metal and the cooling water in the reservoir. This buffer layer provides a hydrodynamic layer which acts to prevent or mitigate steam explosions resulting from hot, molten metal being spilled into or onto the cooling water. 3 figs.

MODELING AIR FLOW DYNAMICS IN RADON MITIGATION SYSTEMS: A SIMPLIFIED APPROACH

EPA Science Inventory

The paper refines and extends an earlier study--relating to the design of optimal radon mitigation systems based on subslab depressurization-- that suggested that subslab air flow induced by a central suction point be treated as radial air flow through a porous bed contained betw...

A Systems Approach to Reducing Institutional GHG Emissions

ERIC Educational Resources Information Center

Williamson, Sean R.

2012-01-01

Purpose: The purpose of this paper is to establish necessity and methods for considering greenhouse gas (GHG) mitigation policies at a system-level. The research emphasizes connecting narrowly focused GHG mitigation objectives (e.g. reduce single occupancy vehicle travel) with broader institutional objectives (e.g. growth in student population) to…

21st century United States emissions mitigation could increase water stress more than the climate change it is mitigating.

PubMed

Hejazi, Mohamad I; Voisin, Nathalie; Liu, Lu; Bramer, Lisa M; Fortin, Daniel C; Hathaway, John E; Huang, Maoyi; Kyle, Page; Leung, L Ruby; Li, Hong-Yi; Liu, Ying; Patel, Pralit L; Pulsipher, Trenton C; Rice, Jennie S; Tesfa, Teklu K; Vernon, Chris R; Zhou, Yuyu

2015-08-25

There is evidence that warming leads to greater evapotranspiration and surface drying, thus contributing to increasing intensity and duration of drought and implying that mitigation would reduce water stresses. However, understanding the overall impact of climate change mitigation on water resources requires accounting for the second part of the equation, i.e., the impact of mitigation-induced changes in water demands from human activities. By using integrated, high-resolution models of human and natural system processes to understand potential synergies and/or constraints within the climate-energy-water nexus, we show that in the United States, over the course of the 21st century and under one set of consistent socioeconomics, the reductions in water stress from slower rates of climate change resulting from emission mitigation are overwhelmed by the increased water stress from the emissions mitigation itself. The finding that the human dimension outpaces the benefits from mitigating climate change is contradictory to the general perception that climate change mitigation improves water conditions. This research shows the potential for unintended and negative consequences of climate change mitigation.

Disease Suppressive Soils: New Insights from the Soil Microbiome

USDA-ARS?s Scientific Manuscript database

In this review, we will present three currently-studied model systems with features representative of specific and general suppressiveness. Based on these systems, we will consider hypotheses about the fundamental nature of specific and general disease-suppressive soil microbial communities, explore...

Final design and fabrication of an active control system for flutter suppression on a supercritical aeroelastic research wing

NASA Technical Reports Server (NTRS)

Hodges, G. E.; Mcgehee, C. R.

1981-01-01

The final design and hardware fabrication was completed for an active control system capable of the required flutter suppression, compatible with and ready for installation in the NASA aeroelastic research wing number 1 (ARW-1) on Firebee II drone flight test vehicle. The flutter suppression system uses vertical acceleration at win buttock line 1.930 (76), with fuselage vertical and roll accelerations subtracted out, to drive wing outboard aileron control surfaces through appropriate symmetric and antisymmetric shaping filters. The goal of providing an increase of 20 percent above the unaugmented vehicle flutter velocity but below the maximum operating condition at Mach 0.98 is exceeded by the final flutter suppression system. Results indicate that the flutter suppression system mechanical and electronic components are ready for installation on the DAST ARW-1 wing and BQM-34E/F drone fuselage.

Widespread Dieback of Forests in North America under Rapid Global Warming: Response to the VINCERA Future Climate Scenarios Simulated by the MC1 DGVM

NASA Astrophysics Data System (ADS)

Lenihan, J.; Neilson, R.; Bachelet, D.; Drapek, R.

2005-12-01

The VINCERA project is an intercomparison among three dynamic general vegetation models (DGVMs) simulating the response of North American ecosystems to six new future climate scenarios. The scenarios were produced by three general circulation models, each using two different future trace gas emissions scenarios. All of the scenarios are near the warmer end of the Intergovernmental Panel on Climate Change's projected future temperature range. Here we present results from the MC1 DGVM. All major forested ecosystems in North America exhibit carbon sequestration until the late 20th or early 21st century, followed by a drought induced decline and loss of carbon to levels below those at 1900 in the absence of fire suppression. By the end of the 21st century, the entire continent will have lost from 10 to 30 Pg of carbon, depending on the scenario. However, fire suppression can significantly mitigate carbon losses and ecosystem declines, producing a net change in carbon from a loss of about 5 Pg to a gain of about 8 Pg under the different scenarios. Most of the suppression benefits are obtained by forests in the western U.S. Suppression also mitigates carbon losses and conversions to savanna or grassland in the eastern U.S., but forest decline still occurs in the east under all scenarios. Dieback is triggered by two mechanisms. Reduced regional precipitation, variable among the scenarios, is one. The second more pervasive mechanism is the influence of rising temperatures on evapotranspiration. Even with the benefits of enhanced water use efficiency from elevated CO2 and slight increases in precipitation, dramatic increases in temperature can produce widespread forest dieback, and increases in fire severity. The eastern United States appear to be particularly vulnerable, as does the central Canadian boreal forest because of the relative flatness of climate gradients near ecotones. Under some scenarios, dieback is also driven by both increasing temperatures and decreasing precipitation, most notably the southeastern and northwestern United States. Following a period of gradual carbon sequestration, the enhanced evapotranspiration appears to overtake the 'greening' processes producing a rapid dieback. The point of turnaround from greenup to dieback occurs about now for the temperate forests and about a decade from now in the boreal forests, initiating an extended period of rapid losses of ecosystem carbon. These results underscore the critical importance of addressing uncertainties with respect to ecosystem water balance and the direct effects of elevated CO2 concentrations.

Overview of ISS U.S. Fire Detection and Suppression System

NASA Technical Reports Server (NTRS)

Whitaker, Alana

2003-01-01

This paper presents a general overview of the International Space Station's Fire Detection and Suppression System. The topics include: 1) Introduction to Fire Detection and Suppression (FDS); 2) Description of (FDS) Subsystems; 3) FDS System Component Location and Status; 4) FDS System Capabilities; 5) FDS Automatic and Manual Response; 6) Post Fire Atmosphere Restoration and Air Quality Assessment; and 7) FDS Research Needs. This paper is in viewgraph form.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bateman, V.I.; Bell, R.G. III; Brown, F.A.

Sandia National Laboratories (SNL) designs mechanical systems with electronics that must survive high shock environments. These mechanical systems include penetrators that must survive soil, rock, and ice penetration, nuclear transportation casks that must survive transportation environments, and laydown weapons that must survive delivery impact of 125-fps. These mechanical systems contain electronics that may operate during and after the high shock environment and that must be protected from the high shock environments. A study has been started to improve the packaging techniques for the advanced electronics utilized in these mechanical systems because current packaging techniques are inadequate for these more sensitivemore » electronics. In many cases, it has been found that the packaging techniques currently used not only do not mitigate the shock environment but actually amplify the shock environment. An ambitious goal for this packaging study is to avoid amplification and possibly attenuate the shock environment before it reaches the electronics contained in the various mechanical system. As part of the investigation of packaging techniques, a two part study of shock mitigating materials is being conducted. This paper reports the first part of the shock mitigating materials study. A study to compare three thicknesses (0.125, 0.250, and 0.500 in.) of seventeen, unconfined materials for their shock mitigating characteristics has been completed with a split Hopkinson bar configuration. The nominal input as measured by strain gages on the incident Hopkinson bar is 50 fps {at} 100 {micro}s for these tests. It is hypothesized that a shock mitigating material has four purposes: to lengthen the shock pulse, to attenuate the shock pulse, to mitigate high frequency content in the shock pulse, and to absorb energy. Both time domain and frequency domain analyses of the split Hopkinson bar data have been performed to compare the materials` achievement of these purposes.« less

Assessment of rock musician's efferent system functioning using contralateral suppression of otoacoustic emissions.

PubMed

Kumar, Prawin; Grover, Vibhu; Publius A, Sam; Sanju, Himanshu Kumar; Sinha, Sachchidanand

2016-12-01

Contralateral suppression of oto acoustic emission (OAE) is referred as activation of efferent system. Previous literature mentioned about the importance of contralateral suppression of OAEs as a tool to assess efferent system in different groups of population. There is dearth of literature to explore the efferent system function in experienced musicians exposed to rock music using TEOAEs and DPOAEs. Two groups of participant (14 rock musicians and 14 non-musicians) in the age range of 18-25 years were involved in the study. Contralateral suppression of TEOAEs and DPOAEs were measured using ILO (Version 6) in both groups. Descriptive statistics showed higher suppression of TEOAEs and DPOAEs in rock-musicians at most of the frequencies in comparison to non-musicians. For DPOAE measures, Mann Whitney U test results revealed significantly greater DPOAE suppression only at 1 kHz and 3 kHz in rock-musicians compared to non-musicians. For within group comparison, Kruskal Wallis test results revealed there were significant difference observed across most of the frequencies i.e. at 1 kHz, 3 kHz and 6 kHz. For TEOAE measures, Mann Whitney U test results revealed that only at 2 kHz, TEOAE suppression in rock-musician was significantly greater compared to non-musicians. Similarly, Kuskal Wallis test results revealed that within group there were no significant differences observed for most of the frequencies except 2 kHz. Based on the above finding, present study concludes that rock musicians are having better efferent system compared to non-musicians. No suppression effect at few frequencies probably indicates more vulnerability at those frequencies. Contralateral suppression of DPOAE shows more significant finding in comparison to contralateral suppression of TEOAEs in present study.

Multirate Flutter Suppression System Design for the Benchmark Active Controls Technology Wing. Part 1; Theory and Design Procedure

NASA Technical Reports Server (NTRS)

Mason, Gregory S.; Berg, Martin C.; Mukhopadhyay, Vivek

2002-01-01

To study the effectiveness of various control system design methodologies, the NASA Langley Research Center initiated the Benchmark Active Controls Project. In this project, the various methodologies were applied to design a flutter suppression system for the Benchmark Active Controls Technology (BACT) Wing. This report describes a project at the University of Washington to design a multirate suppression system for the BACT wing. The objective of the project was two fold. First, to develop a methodology for designing robust multirate compensators, and second, to demonstrate the methodology by applying it to the design of a multirate flutter suppression system for the BACT wing.

Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats.

PubMed

Mahmood, J; Jelveh, S; Zaidi, A; Doctrow, S R; Hill, R P

2013-02-01

Exposure of civilian populations to radiation due to accident, war or terrorist act is an increasing concern. The lung is one of the more radiosensitive organs that may be affected in people receiving partial-body irradiation and radiation injury in lung is thought to be associated with the development of a prolonged inflammatory response. Here we examined how effectively damage to the lung can be mitigated by administration of drugs initiated at different times after radiation exposure and examined response in adolescent animals for comparison with the young adult animals that we had studied previously. We studied the mitigation efficacy of the isoflavone genistein (50 mg/kg) and the salen-Mn superoxide dismutase-catalase mimetic EUK-207 (8 mg/kg), both of which have been reported to scavenge reactive oxygen species and reduce activity of the NFkB pathway. The drugs were given by subcutaneous injection to 6- to 7-week-old Fisher rats daily starting either immediately or 2 weeks after irradiation with 12 Gy to the whole thorax. The treatment was stopped at 28 weeks post irradiation and the animals were assessed for levels of inflammatory cytokines, activated macrophages, oxidative damage and fibrosis at 48 weeks post irradiation. We demonstrated that both genistein and EUK-207 delayed and suppressed the increased breathing rate associated with pneumonitis. These agents also reduced levels of oxidative damage (50-100%), levels of TGF-β1 expression (75-100%), activated macrophages (20-60%) and fibrosis (60-80%). The adolescent rats developed pneumonitis earlier following irradiation of the lung than did the adult rats leading to greater severe morbidity requiring euthanasia (∼37% in adolescents vs. ∼10% in young adults) but the extent of the mitigation of the damage was similar or slightly greater.

The detectability of nitrous oxide mitigation efficacy in intensively grazed pastures using a multiple-plot micrometeorological technique

NASA Astrophysics Data System (ADS)

McMillan, A. M. S.; Harvey, M. J.; Martin, R. J.; Bromley, A. M.; Evans, M. J.; Mukherjee, S.; Laubach, J.

2014-05-01

Methodologies are required to verify agricultural greenhouse gas mitigation at scales relevant to farm management. Micrometeorological techniques provide a viable approach for comparing fluxes between fields receiving mitigation treatments and control fields. However, they have rarely been applied to spatially verifying treatments aimed at mitigating nitrous oxide emission from intensively grazed pastoral systems. We deployed a micrometeorological system to compare N2O flux among several ~1.5 ha plots in intensively grazed dairy pasture. The sample collection and measurement system is referred to as the Field-Scale Nitrous Oxide Mitigation Assessment System (FS-NOMAS) and used a tuneable diode laser absorption spectrometer to measure N2O gradients to high precision at four locations along a 300 m transect. The utility of the FS-NOMAS to assess mitigation efficacy depends largely on its ability to resolve very small vertical N2O gradients. The performance of the FS-NOMAS was assessed in this respect in laboratory and field-based studies. The FS-NOMAS could reliably resolve gradients of 0.039 ppb between a height of 0.5 and 1.0 m. The gradient resolution achieved corresponded to the ability to detect an inter-plot N2O flux difference of 26 μg N2O-N m-2 h-1 under the most commonly encountered conditions of atmospheric mixing (quantified here by a turbulent transfer coefficient), but this ranged from 11 to 59 μg N2O-N m-2 h-1 as the transfer coefficient ranged between its 5th and 95th percentile. Assuming a likely value of 100 μg N2O-N m-2 h-1 for post-grazing N2O fluxes from intensively grazed New Zealand dairy pasture, the system described here would be capable of detecting a mitigation efficacy of 26% for a single (40 min) comparison. We demonstrate that the system has considerably greater sensitivity to treatment effects by measuring cumulative fluxes over extended periods.

The detectability of nitrous oxide mitigation efficacy in intensively grazed pastures using a multiple plot micrometeorological technique

NASA Astrophysics Data System (ADS)

McMillan, A. M. S.; Harvey, M. J.; Martin, R. J.; Bromley, A. M.; Evans, M. J.; Mukherjee, S.; Laubach, J.

2013-10-01

Methodologies are required to verify agricultural greenhouse gas mitigation at scales relevant to farm management. Micrometeorological techniques provide a viable approach for comparing fluxes between fields receiving mitigation treatments and control fields. However, they have rarely been applied to spatially verifying treatments aimed at mitigating nitrous oxide emission from intensively grazed pastoral systems. We deployed a micrometeorological system to compare N2O flux among several ~ 1.5 ha plots in intensively grazed dairy pasture. The sample collection and measurement system is referred to as the Field-Scale Nitrous Oxide Mitigation Assessment System (FS-NOMAS) and used a tuneable diode laser absorption spectrometer to measure N2O gradients to high precision at four locations along a 300 m transect. The utility of the FS-NOMAS to assess mitigation efficacy depends largely on its ability to resolve very small vertical N2O gradients. The performance of the FS-NOMAS was assessed in this respect in laboratory and field-based studies. The FS-NOMAS could reliably resolve gradients of 0.039 ppb between a height of 0.5 m and 1.0 m. The gradient resolution achieved corresponded to the ability to detect an inter-plot N2O flux difference of 26.4 μg N2O-N m-2 h-1 under the most commonly encountered conditions of atmospheric mixing (quantified here by a turbulent transfer coefficient), but this ranged from 11 to 59 μg N2O-N m-2 h-1 as the transfer coefficient ranged between its 5th and 95th percentile. Assuming a likely value of 100 μg N2O-N m-2 h-1 for post-grazing N2O fluxes from intensively grazed New Zealand dairy pasture, the system described here would be capable of detecting a mitigation efficacy of 26% for a single (40 min) comparison. We demonstrate that the system has considerably greater sensitivity to treatment effects by measuring cumulative fluxes over extended periods.

Can re-regulation reservoirs and batteries cost-effectively mitigate sub-daily hydropeaking?

NASA Astrophysics Data System (ADS)

Haas, J.; Nowak, W.; Anindito, Y.; Olivares, M. A.

2017-12-01

To compensate for mismatches between generation and load, hydropower plants frequently operate in strong hydropeaking schemes, which is harmful to the downstream ecosystem. Furthermore, new power market structures and variable renewable systems may exacerbate this behavior. Ecological constraints (minimum flows, maximum ramps) are frequently used to mitigate hydropeaking, but these stand in direct tradeoff with the operational flexibility required for integrating renewable technologies. Fortunately, there are also physical methods (i.e. re-regulation reservoirs and batteries) but to date, there are no studies about their cost-effectiveness for hydropeaking mitigation. This study aims to fill that gap. For this, we formulate an hourly mixed-integer linear optimization model to plan the weekly operation of a hydro-thermal-renewable power system from southern Chile. The opportunity cost of water (needed for this weekly scheduling) is obtained from a mid-term programming solved with dynamic programming. We compare the current (unconstrained) hydropower operation with an ecologically constrained operation. The resulting cost increase is then contrasted with the annual payments necessary for the physical hydropeaking mitigation options. For highly constrained operations, both re-regulation reservoirs and batteries show to be economically attractive for hydropeaking mitigation. For intermediate constrained scenarios, re-regulation reservoirs are still economic, whereas batteries can be a viable solution only if they become cheaper in future. Given current cost projections, their break-even point (for hydropeaking mitigation) is expected within the next ten years. Finally, less stringent hydropeaking constraints do not justify physical mitigation measures, as the necessary flexibility can be provided by other power plants of the system.

HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation

PubMed Central

Kim, Hyeon Ju; Chuang, De-Maw

2014-01-01

White matter injury is an important component of stroke pathology, but its pathophysiology and potential treatment remain relatively elusive and underexplored. We previously reported that after permanent middle cerebral artery occlusion (pMCAO), sodium butyrate (SB) and trichostatin A (TSA) induced neurogenesis via histone deacetylase (HDAC) inhibition in multiple ischemic brain regions in rats; these effects-which depended on activation of brain-derived neurotrophic factor (BDNF)-TrkB signaling-contributed to behavioral improvement. The present study found that SB or TSA robustly protected against ischemia-induced loss of oligodendrocytes detected by confocal microscopy of myelin basic protein (MBP) immunostaining in the ipsilateral subventricular zone (SVZ), striatum, corpus callosum, and frontal cortex seven days post-pMCAO. Co-localization of 5-bromo-2’-deoxyuridine (BrdU)+ and MBP+ cells after SB treatment suggested the occurrence of oligodendrogenesis. SB also strongly upregulated vascular endothelial growth factor (VEGF), which plays a major role in neurogenesis, angiogenesis, and functional recovery after stroke. These SB-induced effects were markedly suppressed by blocking the TrkB signaling pathway with K252a. pMCAO-induced activation of microglia (OX42+) and macrophages/monocytes (ED1+)-which has been linked to white matter injury-was robustly suppressed by SB in a K252a-sensitive manner. In addition, SB treatment largely blocked caspase-3+ and OX42+ cells in ipsilateral brain regions. Our results suggest that HDAC inhibitor-mediated protection against ischemia-induced oligodendrocyte loss may involve multiple mechanisms including oligodendrogenesis, VEGF upregulation, anti-inflammation, and caspase-3 downregulation. Taken together, the results suggest that post-insult treatment with HDAC inhibitors is a rational strategy to mitigate white matter injury following ischemic stroke. PMID:24936215

Novel synthetic monoketone transmute radiation-triggered NFκB-dependent TNFα cross-signaling feedback maintained NFκB and favors neuroblastoma regression.

PubMed

Aravindan, Sheeja; Natarajan, Mohan; Awasthi, Vibhudutta; Herman, Terence S; Aravindan, Natarajan

2013-01-01

Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion. Further, we reported that curcumin targets IR-induced survival signaling and NFκB dependent hTERT mediated clonal expansion in human NB cells. Herein, we investigated the efficacy of a novel synthetic monoketone, EF24, a curcumin analog in inhibiting persistent NFκB activation by disrupting the IR-induced NFκB-TNFα-NFκB feedback signaling in NB and subsequent mitigation of survival advantage and clonal expansion. EF24 profoundly suppressed the IR-induced NFκB-DNA binding activity/promoter activation and, maintained the NFκB repression by deterring NFκB-dependent TNFα transactivation/intercellular secretion in genetically varied human NB (SH-SY5Y, IMR-32, SK-PN-DW, MC-IXC and SK-N-MC) cell types. Further, EF24 completely suppressed IR-induced NFκB-TNFα cross-signaling dependent transactivation/translation of pro-survival IAP1, IAP2 and Survivin and subsequent cell survival. In corroboration, EF24 treatment maximally blocked IR-induced NFκB dependent hTERT transactivation/promoter activation, telomerase activation and consequent clonal expansion. EF24 displayed significant regulation of IR-induced feedback dependent NFκB and NFκB mediated survival signaling and complete regression of NB xenograft. Together, the results demonstrate for the first time that, novel synthetic monoketone EF24 potentiates radiotherapy and mitigates NB progression by selectively targeting IR-triggered NFκB-dependent TNFα-NFκB cross-signaling maintained NFκB mediated survival advantage and clonal expansion.

Novel Synthetic Monoketone Transmute Radiation-Triggered NFκB-Dependent TNFα Cross-Signaling Feedback Maintained NFκB and Favors Neuroblastoma Regression

PubMed Central

Aravindan, Sheeja; Natarajan, Mohan; Awasthi, Vibhudutta; Herman, Terence S.; Aravindan, Natarajan

2013-01-01

Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion. Further, we reported that curcumin targets IR-induced survival signaling and NFκB dependent hTERT mediated clonal expansion in human NB cells. Herein, we investigated the efficacy of a novel synthetic monoketone, EF24, a curcumin analog in inhibiting persistent NFκB activation by disrupting the IR-induced NFκB-TNFα-NFκB feedback signaling in NB and subsequent mitigation of survival advantage and clonal expansion. EF24 profoundly suppressed the IR-induced NFκB-DNA binding activity/promoter activation and, maintained the NFκB repression by deterring NFκB-dependent TNFα transactivation/intercellular secretion in genetically varied human NB (SH-SY5Y, IMR-32, SK–PN–DW, MC-IXC and SK–N-MC) cell types. Further, EF24 completely suppressed IR-induced NFκB-TNFα cross-signaling dependent transactivation/translation of pro-survival IAP1, IAP2 and Survivin and subsequent cell survival. In corroboration, EF24 treatment maximally blocked IR-induced NFκB dependent hTERT transactivation/promoter activation, telomerase activation and consequent clonal expansion. EF24 displayed significant regulation of IR-induced feedback dependent NFκB and NFκB mediated survival signaling and complete regression of NB xenograft. Together, the results demonstrate for the first time that, novel synthetic monoketone EF24 potentiates radiotherapy and mitigates NB progression by selectively targeting IR-triggered NFκB-dependent TNFα-NFκB cross-signaling maintained NFκB mediated survival advantage and clonal expansion. PMID:23967300

The role of non-CO2 mitigation within the dairy sector in pursuing climate goals

NASA Astrophysics Data System (ADS)

Rolph, K.; Forest, C. E.

2017-12-01

Mitigation of non-CO2 climate forcing agents must complement the mitigation of carbon dioxide (CO2) to achieve long-term temperature and climate policy goals. By using multi-gas mitigation strategies, society can limit the rate of temperature change on decadal timescales and reduce the cost of implementing policies that only consider CO2 mitigation. The largest share of global non-CO2 greenhouse gas emissions is attributed to agriculture, with activities related to dairy production contributing the most in this sector. Approximately 4% of global anthropogenic greenhouse gas emissions is released from the dairy sub-sector, primarily through enteric fermentation, feed production, and manure management. Dairy farmers can significantly reduce their emissions by implementing better management practices. This study assesses the potential mitigation of projected climate change if greenhouse gases associated with the dairy sector were reduced. To compare the performance of several mitigation measures under future climate change, we employ a fully coupled earth system model of intermediate complexity, the MIT Integrated Global System Model (IGSM). The model includes an interactive carbon-cycle capable of addressing important feedbacks between the climate and terrestrial biosphere. Mitigation scenarios are developed using estimated emission reductions of implemented management practices studied by the USDA-funded Sustainable Dairy Project (Dairy-CAP). We examine pathways to reach the US dairy industry's voluntary goal of reducing dairy emissions 25% by 2020. We illustrate the importance of ongoing mitigation efforts in the agricultural industry to reduce non-CO2 greenhouse gas emissions towards established climate goals.

Hybrid time-frequency domain equalization for LED nonlinearity mitigation in OFDM-based VLC systems.

PubMed

Li, Jianfeng; Huang, Zhitong; Liu, Xiaoshuang; Ji, Yuefeng

2015-01-12

A novel hybrid time-frequency domain equalization scheme is proposed and experimentally demonstrated to mitigate the white light emitting diode (LED) nonlinearity in visible light communication (VLC) systems based on orthogonal frequency division multiplexing (OFDM). We handle the linear and nonlinear distortion separately in a nonlinear OFDM system. The linear part is equalized in frequency domain and the nonlinear part is compensated by an adaptive nonlinear time domain equalizer (N-TDE). The experimental results show that with only a small number of parameters the nonlinear equalizer can efficiently mitigate the LED nonlinearity. With the N-TDE the modulation index (MI) and BER performance can be significantly enhanced.

Under-Body Blast Mitigation: Stand-Alone Seat Safety Activation System

DTIC Science & Technology

2014-04-01

Restraints, Airbags or other protection systems) to mitigate injury to the occupant during the onset of the event. Injuries may occur as soon as 2.5 ms...cost-effective sensor to accurately and consistently deploy airbags and other pyrotechnic restraint systems based on accelerometers and other...Circuitry are critically important in order to activate the initiators of air bags and pyrotechnic restraint system such as airbags at the very first

Climate mitigation is not the only benefit of a national energy system

NASA Astrophysics Data System (ADS)

Clack, C.

2016-12-01

Many speculate that the main driving force for a continental scale energy system is for climate mitigation. While this is a strong driver, there are multiple co-benefits that emerge from such a transition when purely driven by costs. These components could be managed within a planned system to provide a close-to-optimal solution that enhances the probability of realization. It is shown that these co-benefits of a continental scale electric system occur at costs lower than existing ones. That means there are multiple additional savings without extra costs or effort. The disadvantage is coordination between large geographic regions that could cause more complexity in planning. The main finding from different versions of the NEWS simulator is that carbon mitigation is enhanced by larger systems. In addition, there are increased jobs, reduced water consumption, Sulphur dioxide emissions, Nitrogen oxide emissions, a more distributed electric system and a lower cost of electricity.

Streamlining Traffic Mitigation Fees

DOT National Transportation Integrated Search

1999-01-01

The City of Lacey rewrote the ordinance governing collection of fees to mitigate : development impacts on the transportation system. Previously developers : submitted traffic generation and distribution reports prepared by qualified : traffic enginee...

Acquisition of a Scanning Laser Vibrometer System for Experimental Studies on Nonparametric Nonlinear System Identification and Aeroelastic Instability Suppression

DTIC Science & Technology

2011-03-06

based LCO suppression system housed in a winglet , specifically designed for the GTW. Upon completion of rehabilitation and modifications to the wing to...accommodate the winglet /NES, the full system will be ready for additional testing in the TDT. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF...University, will result in the design of an NES-based LCO suppression system housed in a winglet , specifically designed for the GTW. Upon completion of

Predicting, examining, and evaluating FAC in US power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohn, M.J.; Garud, Y.S.; Raad, J. de

1999-11-01

There have been many pipe failures in fossil and nuclear power plant piping systems caused by flow-accelerated corrosion (FAC). In some piping systems, this failure mechanism maybe the most important type of damage to mitigate because FAC damage has led to catastrophic failures and fatalities. Detecting the damage and mitigating the problem can significantly reduce future forced outages and increase personnel safety. This article discusses the implementation of recent developments to select FAC inspection locations, perform cost-effective examinations, evaluate results, and mitigate FAC failures. These advances include implementing the combination of software to assist in selecting examination locations and anmore » improved pulsed eddy current technique to scan for wall thinning without removing insulation. The use of statistical evaluation methodology and possible mitigation strategies also are discussed.« less

Role of p53–fibrinolytic system cross-talk in the regulation of quartz-induced lung injury

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhandary, Yashodhar P.; Shetty, Shwetha K.; Marudamuthu, Amarnath S.

2015-03-01

Silica is the major component of airborne dust generated by wind, manufacturing and/or demolition. Chronic occupational inhalation of silica dust containing crystalline quartz is by far the predominant form of silicosis in humans. Silicosis is a progressive lung disease that typically arises after a very long latency and is a major occupational concern with no known effective treatment. The mechanism of silicosis is not clearly understood. However, silicosis is associated with increased cell death, expression of redox enzymes and pro-fibrotic cytokines and chemokines. Since alveolar epithelial cell (AEC) death and disruption of alveolar fibrinolysis is often associated with both acutemore » and chronic lung injuries, we explored whether p53-mediated changes in the urokinase-type plasminogen activator (uPA) system contributes to silica-induced lung injury. We further sought to determine whether caveolin-1 scaffolding domain peptide (CSP), which inhibits p53 expression, mitigates lung injury associated with exposure to silica. Lung tissues and AECs isolated from wild-type (WT) mice exposed to silica exhibit increased apoptosis, p53 and PAI-1, and suppression of uPA expression. Treatment of WT mice with CSP inhibits PAI-1, restores uPA expression and prevents AEC apoptosis by suppressing p53, which is otherwise induced in mice exposed to silica. The process involves CSP-mediated inhibition of serine-15 phosphorylation of p53 by inhibition of protein phosphatase 2A-C (PP2A-C) interaction with silica-induced caveolin-1 in AECs. These observations suggest that changes in the p53–uPA fibrinolytic system cross-talk contribute to lung injury caused by inhalation of silica dust containing crystalline quartz and is protected by CSP by targeting this pathway. - Highlights: • Chronic exposure to quartz dusts is a major cause of lung injury and silicosis. • The survival of patients with silicosis is bleak due to lack of effective treatments. • This study defines a new role of p53–uPA cross-talk in quartz-induced lung injury. • Targeting the p53–uPA system inhibits ATII cell/lung injury due to quartz exposure.« less

Construction and measurements of an improved vacuum-swing-adsorption radon-mitigation system

NASA Astrophysics Data System (ADS)

Street, J.; Bunker, R.; Dunagan, C.; Loose, X.; Schnee, R. W.; Stark, M.; Sundarnath, K.; Tronstad, D.

2015-08-01

In order to reduce backgrounds from radon-daughter plate-out onto detector surfaces, an ultra-low-radon cleanroom is being commissioned at the South Dakota School of Mines and Technology. An improved vacuum-swing-adsorption radon mitigation system and cleanroom build upon a previous design implemented at Syracuse University that achieved radon levels of ˜0.2 Bq m-3. This improved system will employ a better pump and larger carbon beds feeding a redesigned cleanroom with an internal HVAC unit and aged water for humidification. With the rebuilt (original) radon mitigation system, the new low-radon cleanroom has already achieved a > 300× reduction from an input activity of 58.6 ± 0.7 Bq m-3 to a cleanroom activity of 0.13 ± 0.06 Bq m-3.

Mitigation of methane emissions in cities: How new measurements and partnerships can contribute to emissions reduction strategies

NASA Astrophysics Data System (ADS)

Hopkins, Francesca M.; Ehleringer, James R.; Bush, Susan E.; Duren, Riley M.; Miller, Charles E.; Lai, Chun-Ta; Hsu, Ying-Kuang; Carranza, Valerie; Randerson, James T.

2016-09-01

Cities generate 70% of anthropogenic greenhouse gas emissions, a fraction that is growing with global urbanization. While cities play an important role in climate change mitigation, there has been little focus on reducing urban methane (CH4) emissions. Here, we develop a conceptual framework for CH4 mitigation in cities by describing emission processes, the role of measurements, and a need for new institutional partnerships. Urban CH4 emissions are likely to grow with expanding use of natural gas and organic waste disposal systems in growing population centers; however, we currently lack the ability to quantify this increase. We also lack systematic knowledge of the relative contribution of these distinct source sectors on emissions. We present new observations from four North American cities to demonstrate that CH4 emissions vary in magnitude and sector from city to city and hence require different mitigation strategies. Detections of fugitive emissions from these systems suggest that current mitigation approaches are absent or ineffective. These findings illustrate that tackling urban CH4 emissions will require research efforts to identify mitigation targets, develop and implement new mitigation strategies, and monitor atmospheric CH4 levels to ensure the success of mitigation efforts. This research will require a variety of techniques to achieve these objectives and should be deployed in cities globally. We suggest that metropolitan scale partnerships may effectively coordinate systematic measurements and actions focused on emission reduction goals.

Cost-Effectiveness of Nitrogen Mitigation by Alternative ...

EPA Pesticide Factsheets

Household wastewater, especially from conventional septic systems, is a major contributor to nitrogen pollution. Alternative household wastewater management technologies provide similar sewerage management services but their life cycle costs and nitrogen flow implications remain uncertain. We seek to address two key questions: (1) what are the total costs, nitrogen mitigation potential, and cost-effectiveness of a range of conventional and alternative municipal wastewater treatment technologies, and (2) what uncertainties influence these outcomes, and how can we improve our understanding of these technologies? We estimate a household nitrogen mass balance for various household wastewater treatment systems and combine this mass balance with life cycle cost assessment to calculate the cost-effectiveness of nitrogen mitigation, which we define as nitrogen removed from the local watershed. We apply our methods to Falmouth, MA, where failing septic systems have caused heightened eutrophication in local receiving water bodies. We find that flushing and dry (composting) urine-diversion toilets paired with conventional septic systems for greywater management demonstrate the lowest life cycle cost and highest cost-effectiveness (dollars per kilogram of nitrogen removed from the watershed). Composting toilets and neighborhood-scale blackwater digesters are also attractive options in some cases, particularly best-case nitrogen mitigation; innovative/advanced septic system

Development of Modeling Capabilities for Launch Pad Acoustics and Ignition Transient Environment Prediction

NASA Technical Reports Server (NTRS)

West, Jeff; Strutzenberg, Louise L.; Putnam, Gabriel C.; Liever, Peter A.; Williams, Brandon R.

2012-01-01

This paper presents development efforts to establish modeling capabilities for launch vehicle liftoff acoustics and ignition transient environment predictions. Peak acoustic loads experienced by the launch vehicle occur during liftoff with strong interaction between the vehicle and the launch facility. Acoustic prediction engineering tools based on empirical models are of limited value in efforts to proactively design and optimize launch vehicles and launch facility configurations for liftoff acoustics. Modeling approaches are needed that capture the important details of the plume flow environment including the ignition transient, identify the noise generation sources, and allow assessment of the effects of launch pad geometric details and acoustic mitigation measures such as water injection. This paper presents a status of the CFD tools developed by the MSFC Fluid Dynamics Branch featuring advanced multi-physics modeling capabilities developed towards this goal. Validation and application examples are presented along with an overview of application in the prediction of liftoff environments and the design of targeted mitigation measures such as launch pad configuration and sound suppression water placement.

Use of gas-phase ethanol to mitigate extreme UV/water oxidation of extreme UV optics

NASA Astrophysics Data System (ADS)

Klebanoff, L. E.; Malinowski, M. E.; Clift, W. M.; Steinhaus, C.; Grunow, P.

2004-03-01

A technique is described that uses a gas-phase species to mitigate the oxidation of a Mo/Si multilayer optic caused by either extreme UV (EUV) or electron-induced dissociation of adsorbed water vapor. It is found that introduction of ethanol (EtOH) into a water-rich gas-phase environment inhibits oxidation of the outermost Si layer of the Mo/Si EUV reflective coating. Auger electron spectroscopy, sputter Auger depth profiling, EUV reflectivity, and photocurrent measurements are presented that reveal the EUV/water- and electron/water-derived optic oxidation can be suppressed at the water partial pressures used in the tests (~2×10-7-2×10-5 Torr). The ethanol appears to function differently in two time regimes. At early times, ethanol decomposes on the optic surface, providing reactive carbon atoms that scavenge reactive oxygen atoms before they can oxidize the outermost Si layer. At later times, the reactive carbon atoms form a thin (~5 Å), possibly self-limited, graphitic layer that inhibits water adsorption on the optic surface. .

An ITPA joint experiment to study runaway electron generation and suppression

DOE PAGES

Granetz, Robert S.; Esposito, B.; Kim, J. H.; ...

2014-07-11

Recent results from an ITPA joint experiment to study the onset, growth, and decay of relativistic electrons (REs) indicate that loss mechanisms other than collisional damping may play a dominant role in the dynamics of the RE population, even during the quiescent Ip flattop. Understanding the physics of RE growth and mitigation is motivated by the theoretical prediction that disruptions of full-current (15 MA) ITER discharges could generate up to 10 MA of REs with 10-20 MeV energies. The ITPA MHD group is conducting a joint experiment to measure the RE detection threshold conditions on a number of tokamaks undermore » quasi-steady-state conditions in which V loop, n e, and REs can be well-diagnosed and compared to collisional theory. Data from DIII-D, C-Mod, FTU, KSTAR, and TEXTOR have been obtained so far, and the consensus to date is that the threshold E-field is significantly higher than predicted by relativistic collisional theory, or conversely, the density required to damp REs is significantly less than predicted, which could have significant implications for RE mitigation on ITER.« less

Ultraviolet radiation-induced suppression of contact hypersensitivity in relation to padimate O and oxybenzone.

PubMed

Fisher, M S; Menter, J M; Willis, I

1989-03-01

Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315 nm radiation. In this study, we investigated whether a commercially available water-resistant sunscreen, either SPF-6 or SPF-15, containing Padimate O (UVB absorber) and oxybenzone (UVA absorber), was effective in preventing systemic suppression of CHS induced by either FS36 sunlamp exposure or solar simulating radiation. We observed that these two sunscreen preparations were totally incapable of preventing the immunologic suppression of contact hypersensitivity by UV radiation. These results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed. Thus, erythema may not be a good end point for assessing systemic immune suppression and its consequences.

Interference Mitigation for Cyber-Physical Wireless Body Area Network System Using Social Networks.

PubMed

Zhang, Zhaoyang; Wang, Honggang; Wang, Chonggang; Fang, Hua

2013-06-01

Wireless body area networks (WBANs) are cyber-physical systems (CPS) that have emerged as a key technology to provide real-time health monitoring and ubiquitous healthcare services. WBANs could operate in dense environments such as in a hospital and lead to a high mutual communication interference in many application scenarios. The excessive interferences will significantly degrade the network performance including depleting the energy of WBAN nodes more quickly, and even eventually jeopardize people's lives due to unreliable (caused by the interference) healthcare data collections. Therefore, It is critical to mitigate the interference among WBANs to increase the reliability of the WBAN system while minimizing the system power consumption. Many existing approaches can deal with communication interference mitigation in general wireless networks but are not suitable for WBANs due to their ignoring the social nature of WBANs. Unlike the previous research, we for the first time propose a power game based approach to mitigate the communication interferences for WBANs based on the people's social interaction information. Our major contributions include: (1) model the inter-WBANs interference, and determine the distance distribution of the interference through both theoretical analysis and Monte Carlo simulations; (2) develop social interaction detection and prediction algorithms for people carrying WBANs; (3) develop a power control game based on the social interaction information to maximize the system's utility while minimize the energy consumption of WBANs system. The extensive simulation results show the effectiveness of the power control game for inter-WBAN interference mitigation using social interaction information. Our research opens a new research vista of WBANs using social networks.

Hematopoietic Stem Cell Injury Induced by Ionizing Radiation

PubMed Central

Shao, Lijian; Luo, Yi

2014-01-01

Abstract Significance: Exposure to ionizing radiation (IR) as the result of nuclear accidents or terrorist attacks is a significant threat and a major medical concern. Hematopoietic stem cell (HSC) injury is the primary cause of death after accidental or intentional exposure to a moderate or high dose of IR. Protecting HSCs from IR should be a primary goal in the development of novel medical countermeasures against radiation. Recent Advances: Significant progress has been made in our understanding of the mechanisms by which IR causes HSC damage. The mechanisms include (i) induction of HSC apoptosis via the p53-Puma pathway; (ii) promotion of HSC differentiation via the activation of the G-CSF/Stat3/BATF-dependent differentiation checkpoint; (iii) induction of HSC senescence via the ROS-p38 pathway; and (iv) damage to the HSC niche. Critical Issues: Induction of apoptosis in HSCs and hematopoietic progenitor cells is primarily responsible for IR-induced acute bone marrow (BM) injury. Long-term BM suppression caused by IR is mainly attributable to the induction of HSC senescence. However, the promotion of HSC differentiation and damage to the HSC niche can contribute to both the acute and long-term effects of IR on the hematopoietic system. Future Directions: In this review, we have summarized a number of recent findings that provide new insights into the mechanisms whereby IR damages HSCs. These findings will provide new opportunities for developing a mechanism-based strategy to prevent and/or mitigate IR-induced BM suppression. Antioxid. Redox Signal. 20, 1447–1462. PMID:24124731

Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen.

PubMed

Li, Xiaonan; DuBois, Debra C; Song, Dawei; Almon, Richard R; Jusko, William J; Chen, Xijing

2017-07-01

Dexamethasone (DEX), a widely prescribed corticosteroid, has long been the cornerstone of the treatment of inflammation and immunologic dysfunctions in rheumatoid arthritis. Corticosteroids are frequently used in combination with other antirheumatic agents such as nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs to mitigate disease symptoms and minimize unwanted effects. We explored the steroid dose-sparing potential of the NSAID naproxen (NPX) with in vitro and in vivo studies. The single and joint suppressive effects of DEX and NPX on the in vitro mitogen-induced proliferation of T lymphocytes in blood and their anti-inflammatory actions on paw edema were investigated in female and male Lewis rats with collagen-induced arthritis (CIA). As expected, DEX was far more potent than NPX in these systems. Mathematical models incorporating an interaction term ψ were applied to quantitatively assess the nature and intensity of pharmacodynamic interactions between DEX and NPX. Modest synergistic effects of the two drugs were found in suppressing the mitogenic response of T lymphocytes. A pharmacokinetic/pharmacodynamic/disease progression model integrating dual drug inhibition quantitatively described the pharmacokinetics, time-course of single and joint anti-inflammatory effects (paw edema), and sex differences in CIA rats, and indicated additive effects of DEX and NPX. Further model simulations demonstrated the promising steroid-sparing potential of NPX in CIA rats, with the beneficial effects of the combination therapy more likely in males than females. Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.

Texture orientation-based algorithm for detecting infrared maritime targets.

PubMed

Wang, Bin; Dong, Lili; Zhao, Ming; Wu, Houde; Xu, Wenhai

2015-05-20

Infrared maritime target detection is a key technology for maritime target searching systems. However, in infrared maritime images (IMIs) taken under complicated sea conditions, background clutters, such as ocean waves, clouds or sea fog, usually have high intensity that can easily overwhelm the brightness of real targets, which is difficult for traditional target detection algorithms to deal with. To mitigate this problem, this paper proposes a novel target detection algorithm based on texture orientation. This algorithm first extracts suspected targets by analyzing the intersubband correlation between horizontal and vertical wavelet subbands of the original IMI on the first scale. Then the self-adaptive wavelet threshold denoising and local singularity analysis of the original IMI is combined to remove false alarms further. Experiments show that compared with traditional algorithms, this algorithm can suppress background clutter much better and realize better single-frame detection for infrared maritime targets. Besides, in order to guarantee accurate target extraction further, the pipeline-filtering algorithm is adopted to eliminate residual false alarms. The high practical value and applicability of this proposed strategy is backed strongly by experimental data acquired under different environmental conditions.

Optimal control of soybean aphid in the presence of natural enemies and the implied value of their ecosystem services.

PubMed

Zhang, Wei; Swinton, Scott M

2012-04-15

By suppressing pest populations, natural enemies provide an important ecosystem service that maintains the stability of agricultural ecosystems systems and potentially mitigates producers' pest control costs. Integrating natural control services into decisions about pesticide-based control has the potential to significantly improve the economic efficiency of pesticide use, with socially desirable outcomes. Two gaps have hindered the incorporation of natural enemies into pest management decision rules: (1) insufficient knowledge of pest and predator population dynamics and (2) lack of a decision framework for the economic tradeoffs among pest control options. Using a new intra-seasonal, dynamic bioeconomic optimization model, this study assesses how predation by natural enemies contributes to profit-maximizing pest management strategies. The model is applied to the management of the invasive soybean aphid, the most significant serious insect threat to soybean production in North America. The resulting lower bound estimate of the value of natural pest control ecosystem services was estimated at $84 million for the states of Illinois, Indiana, Iowa, Michigan and Minnesota in 2005. Copyright © 2011 Elsevier Ltd. All rights reserved.

A spatially-variant deconvolution method based on total variation for optical coherence tomography images

NASA Astrophysics Data System (ADS)

Almasganj, Mohammad; Adabi, Saba; Fatemizadeh, Emad; Xu, Qiuyun; Sadeghi, Hamid; Daveluy, Steven; Nasiriavanaki, Mohammadreza

2017-03-01

Optical Coherence Tomography (OCT) has a great potential to elicit clinically useful information from tissues due to its high axial and transversal resolution. In practice, an OCT setup cannot reach to its theoretical resolution due to imperfections of its components, which make its images blurry. The blurriness is different alongside regions of image; thus, they cannot be modeled by a unique point spread function (PSF). In this paper, we investigate the use of solid phantoms to estimate the PSF of each sub-region of imaging system. We then utilize Lucy-Richardson, Hybr and total variation (TV) based iterative deconvolution methods for mitigating occurred spatially variant blurriness. It is shown that the TV based method will suppress the so-called speckle noise in OCT images better than the two other approaches. The performance of proposed algorithm is tested on various samples, including several skin tissues besides the test image blurred with synthetic PSF-map, demonstrating qualitatively and quantitatively the advantage of TV based deconvolution method using spatially-variant PSF for enhancing image quality.

Hybrid quantum-classical hierarchy for mitigation of decoherence and determination of excited states

DOE Office of Scientific and Technical Information (OSTI.GOV)

McClean, Jarrod R.; Kimchi-Schwartz, Mollie E.; Carter, Jonathan

Using quantum devices supported by classical computational resources is a promising approach to quantum-enabled computation. One powerful example of such a hybrid quantum-classical approach optimized for classically intractable eigenvalue problems is the variational quantum eigensolver, built to utilize quantum resources for the solution of eigenvalue problems and optimizations with minimal coherence time requirements by leveraging classical computational resources. These algorithms have been placed as leaders among the candidates for the first to achieve supremacy over classical computation. Here, we provide evidence for the conjecture that variational approaches can automatically suppress even nonsystematic decoherence errors by introducing an exactly solvable channelmore » model of variational state preparation. Moreover, we develop a more general hierarchy of measurement and classical computation that allows one to obtain increasingly accurate solutions by leveraging additional measurements and classical resources. In conclusion, we demonstrate numerically on a sample electronic system that this method both allows for the accurate determination of excited electronic states as well as reduces the impact of decoherence, without using any additional quantum coherence time or formal error-correction codes.« less

Robust Duplication with Comparison Methods in Microcontrollers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quinn, Heather Marie; Baker, Zachary Kent; Fairbanks, Thomas D.

Commercial microprocessors could be useful computational platforms in space systems, as long as the risk is bound. Many spacecraft are computationally constrained because all of the computation is done on a single radiation-hardened microprocessor. It is possible that a commercial microprocessor could be used for configuration, monitoring and background tasks that are not mission critical. Most commercial microprocessors are affected by radiation, including single-event effects (SEEs) that could be destructive to the component or corrupt the data. Part screening can help designers avoid components with destructive failure modes, and mitigation can suppress data corruption. We have been experimenting with amore » method for masking radiation-induced faults through the software executing on the microprocessor. While triple-modular redundancy (TMR) techniques are very effective at masking faults in software, the increased amount of execution time to complete the computation is not desirable. Here in this article we present a technique for combining duplication with compare (DWC) with TMR that decreases observable errors by as much as 145 times with only a 2.35 time decrease in performance.« less

Robust Duplication with Comparison Methods in Microcontrollers

DOE PAGES

Quinn, Heather Marie; Baker, Zachary Kent; Fairbanks, Thomas D.; ...

2016-01-01

Commercial microprocessors could be useful computational platforms in space systems, as long as the risk is bound. Many spacecraft are computationally constrained because all of the computation is done on a single radiation-hardened microprocessor. It is possible that a commercial microprocessor could be used for configuration, monitoring and background tasks that are not mission critical. Most commercial microprocessors are affected by radiation, including single-event effects (SEEs) that could be destructive to the component or corrupt the data. Part screening can help designers avoid components with destructive failure modes, and mitigation can suppress data corruption. We have been experimenting with amore » method for masking radiation-induced faults through the software executing on the microprocessor. While triple-modular redundancy (TMR) techniques are very effective at masking faults in software, the increased amount of execution time to complete the computation is not desirable. Here in this article we present a technique for combining duplication with compare (DWC) with TMR that decreases observable errors by as much as 145 times with only a 2.35 time decrease in performance.« less

Resilient carbon encapsulation of iron pyrite (FeS2) cathodes in lithium ion batteries

NASA Astrophysics Data System (ADS)

Yoder, Tara S.; Tussing, Matthew; Cloud, Jacqueline E.; Yang, Yongan

2015-01-01

Converting iron pyrite (FeS2) from a non-cyclable to a cyclable cathode material for lithium ion batteries has been an ongoing challenge in recent years. Herein we report a promising mitigation strategy: wet-chemistry based conformal encapsulation of synthetic FeS2 nanocrystals in a resilient carbon (RC) matrix (FeS2@RC). The FeS2@RC composite was fabricated by dispersing autoclave-synthesized FeS2 nanocrystals in an aqueous glucose solution, polymerizing the glucose in a hydrothermal reactor, and finally heating the polymer/FeS2 composite in a tube furnace to partially carbonize the polymer. The FeS2@RC electrodes showed superior cyclability compared with the FeS2 electrodes, that is, 25% versus 1% of retention at the 20th cycle. Based on electrochemical analysis, XRD study, and SEM characterization, the performance enhancement was attributed to RC's ability to accommodate volume fluctuation, enhance charge transfer, alleviate detrimental side reactions, and suppress loss of the active material. Furthermore, the remaining issues associated with the current system were identified and future research directions were proposed.

Assessment of N2O emission from a photobioreactor treating ammonia-rich swine wastewater digestate.

PubMed

Mezzari, Melissa P; da Silva, Márcio L B; Nicoloso, Rodrigo S; Ibelli, Adriana M G; Bortoli, Marcelo; Viancelli, Aline; Soares, Hugo M

2013-12-01

This study investigated the interactions between naturally occurring bacteria and the microalgae Chlorella vulgaris within a lab scale photobioreactor treating ammonia-rich swine wastewater digestate effluent. Nitrification and denitrification were assessed by targeting ammonia monoxygenases (amoA), nitrate (narG), nitrite (nirS), nitric oxide (norB) and nitrous oxide (nosZ) reductases genes. Oxygen produced from microalgae photosynthesis stimulated nitrification. Under limiting carbon availability (i.e., <1.44 for mg TOC/mg NO2-N and 1.72 for mg TOC/mg NO3-N), incomplete denitrification led to accumulation of NO2 and NO3. Significant N2O emission (up to 118 μg N2O-N) was linked to NO2 metabolism in Chlorella. The addition of acetate as external carbon source recovered heterotrophic denitrification activity suppressing N2O emission. Effluent methane concentrations trapped within photobioreactor was removed concomitantly with ammonia. Overall, closed photobioreactors can be built to effectively remove nitrogen and mitigate simultaneously greenhouse gases emissions that would occur otherwise in open microalgae-based wastewater treatment systems. Copyright © 2013 Elsevier Ltd. All rights reserved.

Make dark matter charged again

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agrawal, Prateek; Cyr-Racine, Francis-Yan; Randall, Lisa

2017-05-01

We revisit constraints on dark matter that is charged under a U(1) gauge group in the dark sector, decoupled from Standard Model forces. We find that the strongest constraints in the literature are subject to a number of mitigating factors. For instance, the naive dark matter thermalization timescale in halos is corrected by saturation effects that slow down isotropization for modest ellipticities. The weakened bounds uncover interesting parameter space, making models with weak-scale charged dark matter viable, even with electromagnetic strength interaction. This also leads to the intriguing possibility that dark matter self-interactions within small dwarf galaxies are extremely large,more » a relatively unexplored regime in current simulations. Such strong interactions suppress heat transfer over scales larger than the dark matter mean free path, inducing a dynamical cutoff length scale above which the system appears to have only feeble interactions. These effects must be taken into account to assess the viability of darkly-charged dark matter. Future analyses and measurements should probe a promising region of parameter space for this model.« less

Quantitative analysis on the urban flood mitigation effect by the extensive green roof system.

PubMed

Lee, J Y; Moon, H J; Kim, T I; Kim, H W; Han, M Y

2013-10-01

Extensive green-roof systems are expected to have a synergetic effect in mitigating urban runoff, decreasing temperature and supplying water to a building. Mitigation of runoff through rainwater retention requires the effective design of a green-roof catchment. This study identified how to improve building runoff mitigation through quantitative analysis of an extensive green-roof system. Quantitative analysis of green-roof runoff characteristics indicated that the extensive green roof has a high water-retaining capacity response to rainfall of less than 20 mm/h. As the rainfall intensity increased, the water-retaining capacity decreased. The catchment efficiency of an extensive green roof ranged from 0.44 to 0.52, indicating reduced runoff comparing with efficiency of 0.9 for a concrete roof. Therefore, extensive green roofs are an effective storm water best-management practice and the proposed parameters can be applied to an algorithm for rainwater-harvesting tank design. © 2013 Elsevier Ltd. All rights reserved.

A systematic review of financial and economic assessments of bovine viral diarrhea virus (BVDV) prevention and mitigation activities worldwide.

PubMed

Pinior, Beate; Firth, Clair L; Richter, Veronika; Lebl, Karin; Trauffler, Martine; Dzieciol, Monika; Hutter, Sabine E; Burgstaller, Johann; Obritzhauser, Walter; Winter, Petra; Käsbohrer, Annemarie

2017-02-01

Infection with bovine viral diarrhea virus (BVDV) results in major economic losses either directly through decreased productive performance in cattle herds or indirectly, such as through expenses for control programs. The aim of this systematic review was to review financial and/or economic assessment studies of prevention and/or mitigation activities of BVDV at national, regional and farm level worldwide. Once all predefined criteria had been met, 35 articles were included for this systematic review. Studies were analyzed with particular focus on the type of financially and/or economically-assessed prevention and/or mitigation activities. Due to the wide range of possible prevention and/or mitigation activities, these activities were grouped into five categories: i) control and/or eradication programs, ii) monitoring or surveillance, iii) prevention, iv) vaccination and v) individual culling, control and testing strategies. Additionally, the studies were analyzed according to economically-related variables such as efficiency, costs or benefits of prevention and/or mitigation activities, the applied financial and/or economic and statistical methods, the payers of prevention and/or mitigation activities, the assessed production systems, and the countries for which such evaluations are available. Financial and/or economic assessments performed in Europe were dominated by those from the United Kingdom, which assessed mostly vaccination strategies, and Norway which primarily carried out assessments in the area of control and eradication programs; whereas among non-European countries the United States carried out the majority of financial and/or economic assessments in the area of individual culling, control and testing. More than half of all studies provided an efficiency calculation of prevention and/or mitigation activities and demonstrated whether the inherent costs of implemented activities were or were not justified. The dairy sector was three times more likely to be assessed by the countries than beef production systems. In addition, the dairy sector was approximately eight times more likely to be assessed economically with respect to prevention and/or mitigation activities than calf and youngstock production systems. Furthermore, the private sector was identified as the primary payer of prevention and/or mitigation activities. This systematic review demonstrated a lack of studies relating to efficiency calculations, in particular at national and regional level, and the specific production systems. Thus, we confirmed the need for more well-designed studies in animal health economics in order to demonstrate that the implementation and inherent costs of BVDV prevention and/or mitigation activities are justified. Copyright © 2016 The Author(s). Published by Elsevier B.V. All rights reserved.

An experimental adaptive array to suppress weak interfering signals

NASA Technical Reports Server (NTRS)

Walton, Eric K.; Gupta, Inder J.; Ksienski, Aharon A.; Ward, James

1988-01-01

An experimental adaptive antenna system to suppress weak interfering signals is described. It is a sidelobe canceller with two auxiliary elements. Modified feedback loops are used to control the array weights. The received signals are simulated in hardware for parameter control. Digital processing is used for algorithm implementation and performance evaluation. The experimental results are presented. They show that interfering signals as much as 10 dB below the thermal noise level in the main channel are suppressed by 20-30 dB. Such a system has potential application in suppressing the interference encountered in direct broadcast satellite communication systems.

Climate change mitigation through livestock system transitions.

PubMed

Havlík, Petr; Valin, Hugo; Herrero, Mario; Obersteiner, Michael; Schmid, Erwin; Rufino, Mariana C; Mosnier, Aline; Thornton, Philip K; Böttcher, Hannes; Conant, Richard T; Frank, Stefan; Fritz, Steffen; Fuss, Sabine; Kraxner, Florian; Notenbaert, An

2014-03-11

Livestock are responsible for 12% of anthropogenic greenhouse gas emissions. Sustainable intensification of livestock production systems might become a key climate mitigation technology. However, livestock production systems vary substantially, making the implementation of climate mitigation policies a formidable challenge. Here, we provide results from an economic model using a detailed and high-resolution representation of livestock production systems. We project that by 2030 autonomous transitions toward more efficient systems would decrease emissions by 736 million metric tons of carbon dioxide equivalent per year (MtCO2e⋅y(-1)), mainly through avoided emissions from the conversion of 162 Mha of natural land. A moderate mitigation policy targeting emissions from both the agricultural and land-use change sectors with a carbon price of US$10 per tCO2e could lead to an abatement of 3,223 MtCO2e⋅y(-1). Livestock system transitions would contribute 21% of the total abatement, intra- and interregional relocation of livestock production another 40%, and all other mechanisms would add 39%. A comparable abatement of 3,068 MtCO2e⋅y(-1) could be achieved also with a policy targeting only emissions from land-use change. Stringent climate policies might lead to reductions in food availability of up to 200 kcal per capita per day globally. We find that mitigation policies targeting emissions from land-use change are 5 to 10 times more efficient--measured in "total abatement calorie cost"--than policies targeting emissions from livestock only. Thus, fostering transitions toward more productive livestock production systems in combination with climate policies targeting the land-use change appears to be the most efficient lever to deliver desirable climate and food availability outcomes.

Climate change mitigation through livestock system transitions

PubMed Central

Havlík, Petr; Valin, Hugo; Herrero, Mario; Obersteiner, Michael; Schmid, Erwin; Rufino, Mariana C.; Mosnier, Aline; Thornton, Philip K.; Böttcher, Hannes; Conant, Richard T.; Frank, Stefan; Fritz, Steffen; Fuss, Sabine; Kraxner, Florian; Notenbaert, An

2014-01-01

Livestock are responsible for 12% of anthropogenic greenhouse gas emissions. Sustainable intensification of livestock production systems might become a key climate mitigation technology. However, livestock production systems vary substantially, making the implementation of climate mitigation policies a formidable challenge. Here, we provide results from an economic model using a detailed and high-resolution representation of livestock production systems. We project that by 2030 autonomous transitions toward more efficient systems would decrease emissions by 736 million metric tons of carbon dioxide equivalent per year (MtCO2e⋅y−1), mainly through avoided emissions from the conversion of 162 Mha of natural land. A moderate mitigation policy targeting emissions from both the agricultural and land-use change sectors with a carbon price of US$10 per tCO2e could lead to an abatement of 3,223 MtCO2e⋅y−1. Livestock system transitions would contribute 21% of the total abatement, intra- and interregional relocation of livestock production another 40%, and all other mechanisms would add 39%. A comparable abatement of 3,068 MtCO2e⋅y−1 could be achieved also with a policy targeting only emissions from land-use change. Stringent climate policies might lead to reductions in food availability of up to 200 kcal per capita per day globally. We find that mitigation policies targeting emissions from land-use change are 5 to 10 times more efficient—measured in “total abatement calorie cost”—than policies targeting emissions from livestock only. Thus, fostering transitions toward more productive livestock production systems in combination with climate policies targeting the land-use change appears to be the most efficient lever to deliver desirable climate and food availability outcomes. PMID:24567375

Forecasting wildland fire behavior using high-resolution large-eddy simulations

NASA Astrophysics Data System (ADS)

Munoz-Esparza, D.; Kosovic, B.; Jimenez, P. A.; Anderson, A.; DeCastro, A.; Brown, B.

2016-12-01

Wildland fires are responsible for large socio-economic impacts. Fires affect the environment, damage structures, threaten lives, cause health issues, and involve large suppression costs. These impacts can be mitigated via accurate fire spread forecast to inform the incident management team. To this end, the state of Colorado is funding the development of the Colorado Fire Prediction System (CO-FPS). The system is based on the Weather Research and Forecasting (WRF) model enhanced with a fire behavior module (WRF-Fire). Realistic representation of wildland fire behavior requires explicit representation of small scale weather phenomena to properly account for coupled atmosphere-wildfire interactions. Moreover, transport and dispersion of biomass burning emissions from wildfires is controlled by turbulent processes in the atmospheric boundary layer, which are difficult to parameterize and typically lead to large errors when simplified source estimation and injection height methods are used. Therefore, we utilize turbulence-resolving large-eddy simulations at a resolution of 111 m to forecast fire spread and smoke distribution using a coupled atmosphere-wildfire model. This presentation will describe our improvements to the level-set based fire-spread algorithm in WRF-Fire and an evaluation of the operational system using 12 wildfire events that occurred in Colorado in 2016, as well as other historical fires. In addition, the benefits of explicit representation of turbulence for smoke transport and dispersion will be demonstrated.

NASA Experience with Pogo in Human Spaceflight Vehicles

NASA Technical Reports Server (NTRS)

Larsen, Curtis E.

2008-01-01

An overview of more than 45 years of NASA human spaceflight experience is presented with respect to the thrust axis vibration response of liquid fueled rockets known as pogo. A coupled structure and propulsion system instability, pogo can result in the impairment of the astronaut crew, an unplanned engine shutdown, loss of mission, or structural failure. The NASA history begins with the Gemini Program and adaptation of the USAF Titan II ballistic missile as a spacecraft launch vehicle. It continues with the pogo experienced on several Apollo-Saturn flights in both the first and second stages of flight. The defining moment for NASA s subsequent treatment of pogo occurred with the near failure of the second stage on the ascent of the Apollo 13 mission. Since that time NASA has had a strict "no pogo" philosophy that was applied to the development of the Space Shuttle. The "no pogo" philosophy lead to the first vehicle designed to be pogo-free from the beginning and the first development of an engine with an integral pogo suppression system. Now, more than 30 years later, NASA is developing two new launch vehicles, the Ares I crew launch vehicle propelling the Orion crew excursion vehicle, and the Ares V cargo launch vehicle. A new generation of engineers must again exercise NASA s system engineering method for pogo mitigation during design, development and verification.

Forecasting wildland fire behavior using high-resolution large-eddy simulations

NASA Astrophysics Data System (ADS)

Munoz-Esparza, D.; Kosovic, B.; Jimenez, P. A.; Anderson, A.; DeCastro, A.; Brown, B.

2017-12-01

Wildland fires are responsible for large socio-economic impacts. Fires affect the environment, damage structures, threaten lives, cause health issues, and involve large suppression costs. These impacts can be mitigated via accurate fire spread forecast to inform the incident management team. To this end, the state of Colorado is funding the development of the Colorado Fire Prediction System (CO-FPS). The system is based on the Weather Research and Forecasting (WRF) model enhanced with a fire behavior module (WRF-Fire). Realistic representation of wildland fire behavior requires explicit representation of small scale weather phenomena to properly account for coupled atmosphere-wildfire interactions. Moreover, transport and dispersion of biomass burning emissions from wildfires is controlled by turbulent processes in the atmospheric boundary layer, which are difficult to parameterize and typically lead to large errors when simplified source estimation and injection height methods are used. Therefore, we utilize turbulence-resolving large-eddy simulations at a resolution of 111 m to forecast fire spread and smoke distribution using a coupled atmosphere-wildfire model. This presentation will describe our improvements to the level-set based fire-spread algorithm in WRF-Fire and an evaluation of the operational system using 12 wildfire events that occurred in Colorado in 2016, as well as other historical fires. In addition, the benefits of explicit representation of turbulence for smoke transport and dispersion will be demonstrated.

A practical approach to the development of aircraft GTE's noise suppression system on the base of fiber optic sensors

NASA Astrophysics Data System (ADS)

Vinogradov, Vasiliy Yu.; Morozov, Oleg G.; Morozov, Gennady A.; Sakhabutdinov, Airat Zh.; Nureev, Ilnur I.; Kuznetsov, Artem A.; Faskhutdinov, Lenar M.; Sarvarova, Lutsia M.

2017-04-01

In this paper, we consider a number of different methods that form the modern approach to the development of aircraft GTE's noise suppression systems at service conditions. The herein-presented efficient noise suppression system on the base of fiber optic sensors makes it possible to reduce pulsations at the exhaust nozzle exit and noise levels at the engine outlet section.

Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

PubMed Central

Price, Jennifer C.; Seaberg, Eric C.; Phair, John P; Witt, Mallory D.; Koletar, Susan L; Thio, Chloe L.

2016-01-01

To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Pre-HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA<500 copies/ml: 16% for HIV-monoinfected and 22% for coinfected. Declines in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men. PMID:26945179

Suppression of radiation-induced point defects by rhenium and osmium interstitials in tungsten

PubMed Central

Suzudo, Tomoaki; Hasegawa, Akira

2016-01-01

Modeling the evolution of radiation-induced defects is important for finding radiation-resistant materials, which would be greatly appreciated in nuclear applications. We apply the density functional theory combined with comprehensive analyses of massive experimental database to indicate a mechanism to mitigate the effect of radiation on W crystals by adding particular solute elements that change the migration property of interstitials. The resultant mechanism is applicable to any body-centered-cubic (BCC) metals whose self-interstitial atoms become a stable crowdion and is expected to provide a general guideline for computational design of radiation-resistant alloys in the field of nuclear applications. PMID:27824134

Formulation of Biocides Increases Antimicrobial Potency and Mitigates the Enrichment of Nonsusceptible Bacteria in Multispecies Biofilms

PubMed Central

Forbes, Sarah; Cowley, Nicola; Mistry, Hitesh; Amézquita, Alejandro

2017-01-01

ABSTRACT The current investigation aimed to generate data to inform the development of risk assessments of biocide usage. Stabilized domestic drain biofilm microcosms were exposed daily over 6 months to increasing concentrations (0.01% to 1%) of the biocide benzalkonium chloride (BAC) in a simple aqueous solution (BAC-s) or in a complex formulation (BAC-f) representative of a domestic cleaning agent. Biofilms were analyzed by culture, differentiating by bacterial functional group and by BAC or antibiotic susceptibility. Bacterial isolates were identified by 16S rRNA sequencing, and changes in biofilm composition were assessed by high-throughput sequencing. Exposure to BAC-f resulted in significantly larger reductions in levels of viable bacteria than exposure to BAC-s, while bacterial diversity greatly decreased during exposure to both BAC-s and BAC-f, as evidenced by sequencing and viable counts. Increases in the abundance of bacteria exhibiting reduced antibiotic or BAC susceptibility following exposure to BAC at 0.1% were significantly greater for BAC-s than BAC-f. Bacteria with reduced BAC and antibiotic susceptibility were generally suppressed by higher BAC concentrations, and formulation significantly enhanced this effect. Significant decreases in the antimicrobial susceptibility of bacteria isolated from the systems before and after long-term BAC exposure were not detected. In summary, dose-dependent suppression of bacterial viability by BAC was enhanced by formulation. Biocide exposure decreased bacterial diversity and transiently enriched populations of organisms with lower antimicrobial susceptibility, and the effects were subsequently suppressed by exposure to 1% BAC-f, the concentration most closely reflecting deployment in formulated products. IMPORTANCE Assessment of the risks of biocide use has been based mainly on the exposure of axenic cultures of bacteria to biocides in simple aqueous solutions. The current investigation aimed to assess the effects of formulation on the outcome of biocide exposure in multispecies biofilms. Formulation of the cationic biocide BAC significantly increased antimicrobial potency. Bacteria with lower antimicrobial susceptibility whose populations were enriched after low-level biocide exposure were more effectively suppressed by the biocide at in-use concentrations (1% [wt/vol]) in a formulation than in a simple aqueous solution. These observations underline the importance of simulating normal deployment conditions in considering the risks and benefits of biocide use. PMID:28115386

Crop performance and weed suppression by weed-suppressive rice cultivars in furrow- and flood-irrigated systems under reduced herbicide inputs

USDA-ARS?s Scientific Manuscript database

Weed control in rice is challenging, particularly in light of increased resistance to herbicides in weed populations and diminishing availability of irrigation water. Certain indica rice cultivars can produce high yields and suppress weeds in conventional flood-irrigated, drill-seeded systems in the...

Nitrous Oxide and Methane Fluxes in Responses to Conservation Management across Cropping Systems in Asia from a Data-Model Integration Perspective

NASA Astrophysics Data System (ADS)

Ren, W.; Huang, Y.; Tao, B.; Zhu, X.; Tian, H.

2017-12-01

The agriculture sector is estimated to be responsible for 12% of the total greenhouse gas emissions, particularly for 52% of CH4 and 84% of N2O. It has been predicted that the world population would reach 9.7 billion by 2050 and require a 60 percent increase in total agricultural production above the level of 2005-07, which would potentially further boost greenhouse gas emissions from agroecosystems. The growing concerns over food security and rapid rate of global warming necessitates the development of conservation management (or climate-smart soil management) that can ensure high crop yield and meanwhile markedly enhance soil sequestration and reduce GHG emissions. In this study, we synthesize multi-source datasets and apply an improved agroecosystem model to quantitatively investigate the dynamics of CH4 and N2O fluxes as influenced by conservation management practices in cropping systems of Asia (such as wheat, corn, and rice) for exploring the potential of those practices to mitigate and adapt to climate change. Our preliminary results suggest that the conservation tillage (e.g., reduced and no tillage) can largely suppress CH4 emissions from Asia's rice paddies, although they, to some extent, may stimulate NO2 emissions, comparing with the conventional tillage.

Space Debris: Its Causes and Management

NASA Technical Reports Server (NTRS)

Johnson, Nicholas L.

2002-01-01

Orbital debris is internationally recognized as an environmental issue which needs to be addressed today to preserve near-Earth space for future generations. All major space agencies are committed to mitigating the growth of the debris environment. Many commercial space system operators have responded positively to orbital debris mitigation principles and recommendations. Orbital debris mitigation measures are most cost-effective if included in the design development phase.

The Empathic Operating System (emOS)

DTIC Science & Technology

2016-06-15

contextual data, including phone calls, locations, and events, to help mitigate the effects of stress on daily life. This approach offers novel...with their contextual data, including phone calls, locations, and events, to help mitigate the effects of stress on daily life. This approach offers...incorporates users’ physiology with their contextual data, including phone calls, locations, and events, to help mitigate the effects of stress on

Debris mitigation measures by satellite design and operational methods - Findings from the DLR space debris End-to-End Service

NASA Astrophysics Data System (ADS)

Sdunnus, H.; Beltrami, P.; Janovsky, R.; Koppenwallner, G.; Krag, H.; Reimerdes, H.; Schäfer, F.

Debris Mitigation has been recognised as an issue to be addressed by the space faring nations around the world. Currently, there are various activities going on, aiming at the establishment of debris mitigation guidelines on various levels, reaching from the UN down to national space agencies. Though guidelines established on the national level already provide concrete information how things should be done (rather that specifying what should be done or providing fundamental principles) potential users of the guidelines will still have the need to explore the technical, management, and financial implications of the guidelines for their projects. Those questions are addressed by the so called "Space Debris End-to-End Service" project, which has been initiated as a national initiative of the German Aerospace Centre (DLR). Based on a review of already existing mitigation guidelines or guidelines under development and following an identification of needs from a circle of industrial users the "End-to-End Service Gu idelines" have been established for designer and operators of spacecraft. The End-to-End Service Guidelines are based on requirements addressed by the mitigation guidelines and provide recommendations how and when the technical consideration of the mitigation guidelines should take place. By referencing requirements from the mitigation guidelines, the End-to-End Service Guidelines address the consideration of debris mitigation measures by spacecraft design and operational measures. This paper will give an introduction to the End-to-End Service Guidelines. It will focus on the proposals made for mitigation measures by the S/C system design, i.e. on protective design measures inside the spacecraft and on design measures, e.g. innovative protective (shielding) systems. Furthermore, approaches on the analytical optimisation of protective systems will be presented, aiming at the minimisation of shield mass under conservation of the protective effects. On the operational side, the possibility to support mitgation measures supported through radar observation will be addressed as well as measures to minimise the risk during the satellite reentry phase by the choice of proper reentry parameters and spacecraft materials and design options.

Human-Systems Integration (HSI) and the Network Integration Evaluations (NIEs), Part 3: Mitigating Cognitive Load in Network-Enabled Mission Command

DTIC Science & Technology

2016-06-01

ARL-TR-7698 ● JUNE 2016 US Army Research Laboratory Human -Systems Integration (HSI) and the Network Integration Evaluations...ARL-TR-7698 ● JUNE 2016 US Army Research Laboratory Human -Systems Integration (HSI) and the Network Integration Evaluations (NIEs), Part 3...Mitigating Cognitive Load in Network-Enabled Mission Command by John K Hawley Human Research and Engineering Directorate, ARL Michael W

Delayed detection of climate mitigation benefits due to climate inertia and variability.

PubMed

Tebaldi, Claudia; Friedlingstein, Pierre

2013-10-22

Climate change mitigation acts by reducing greenhouse gas emissions, and thus curbing, or even reversing, the increase in their atmospheric concentration. This reduces the associated anthropogenic radiative forcing, and hence the size of the warming. Because of the inertia and internal variability affecting the climate system and the global carbon cycle, it is unlikely that a reduction in warming would be immediately discernible. Here we use 21st century simulations from the latest ensemble of Earth System Model experiments to investigate and quantify when mitigation becomes clearly discernible. We use one of the scenarios as a reference for a strong mitigation strategy, Representative Concentration Pathway (RCP) 2.6 and compare its outcome with either RCP4.5 or RCP8.5, both of which are less severe mitigation pathways. We analyze global mean atmospheric CO2, and changes in annually and seasonally averaged surface temperature at global and regional scales. For global mean surface temperature, the median detection time of mitigation is about 25-30 y after RCP2.6 emissions depart from the higher emission trajectories. This translates into detection of a mitigation signal by 2035 or 2045, depending on whether the comparison is with RCP8.5 or RCP4.5, respectively. The detection of climate benefits of emission mitigation occurs later at regional scales, with a median detection time between 30 and 45 y after emission paths separate. Requiring a 95% confidence level induces a delay of several decades, bringing detection time toward the end of the 21st century.

Pegylated IFN-α suppresses hepatitis C virus by promoting the DAPK-mTOR pathway.

PubMed

Liu, Wei-Liang; Yang, Hung-Chih; Hsu, Ching-Sheng; Wang, Chih-Chiang; Wang, Tzu-San; Kao, Jia-Horng; Chen, Ding-Shinn

2016-12-20

Death-associated protein kinase (DAPK) has been found to be induced by IFN, but its antiviral activity remains elusive. Therefore, we investigated whether DAPK plays a role in the pegylated IFN-α (peg-IFN-α)-induced antiviral activity against hepatitis C virus (HCV) replication. Primary human hepatocytes, Huh-7, and infectious HCV cell culture were used to study the relationship between peg-IFN-α and the DAPK-mammalian target of rapamycin (mTOR) pathways. The activation of DAPK and signaling pathways were determined using immunoblotting. By silencing DAPK and mTOR, we further assessed the role of DAPK and mTOR in the peg-IFN-α-induced suppression of HCV replication. Peg-IFN-α up-regulated the expression of DAPK and mTOR, which was associated with the suppression of HCV replication. Overexpression of DAPK enhanced mTOR expression and then inhibited HCV replication. In addition, knockdown of DAPK reduced the expression of mTOR in peg-IFN-α-treated cells, whereas silencing of mTOR had no effect on DAPK expression, suggesting mTOR may be a downstream effector of DAPK. More importantly, knockdown of DAPK or mTOR significantly mitigated the inhibitory effects of peg-IFN-α on HCV replication. In conclusion, our data suggest that the DAPK-mTOR pathway is critical for anti-HCV effects of peg-IFN-α.

Droop Control of Solar PV, Grid and Critical Load using Suppressing DC Current Injection Technique without Battery Storage

NASA Astrophysics Data System (ADS)

Dama Mr., Jayachandra; (Mrs. , Lini Mathew, Dr.; Srikanth Mr., G.

2017-08-01

This paper presents design of a sustainable solar Photo voltaic system for an Indian cities based residential/community house, integrated with grid, supporting it as supplementary sources, to meet energy demand of domestic loads. The role of renewable energy sources in Distributed Generation (DG) is increasingly being recognized as a supplement and an alternative to large conventional central power supply. Though centralized economic system that solely depends on cities is hampered due to energy deficiency, the use of solar energy in cities is never been tried widely due to technical inconvenience and high installation cost. To mitigate these problems, this paper proposes an optimized design of grid-tied PV system without storage which is suitable for Indian origin as it requires less installallation cost and supplies residential loads when the grid power is unavailable. The energy requirement is mainly fulfilled from PV energy module for critical load of a city located residential house and supplemented by grid/DG for base and peak load. The system has been developed for maximum daily household demand of 50kWp and can be scaled to any higher value as per requirement of individual/community building ranging from 50kWp to 60kWp as per the requirement. A simplified control system model has been developed to optimize and control flow of power from these sources. The simulation work, using MATLAB Simulink software for proposed energy management, has resulted in an optimal yield leading efficient power flow control of proposed system.

A built-in mechanism to mitigate the spread of insect-resistance and herbicide-tolerance transgenes into weedy rice populations.

PubMed

Liu, Chengyi; Li, Jingjing; Gao, Jianhua; Shen, Zhicheng; Lu, Bao-Rong; Lin, Chaoyang

2012-01-01

The major challenge of cultivating genetically modified (GM) rice (Oryza sativa) at the commercial scale is to prevent the spread of transgenes from GM cultivated rice to its coexisting weedy rice (O. sativa f. spontanea). The strategic development of GM rice with a built-in control mechanism can mitigate transgene spread in weedy rice populations. An RNAi cassette suppressing the expression of the bentazon detoxifying enzyme CYP81A6 was constructed into the T-DNA which contained two tightly linked transgenes expressing the Bt insecticidal protein Cry1Ab and the glyphosate tolerant 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), respectively. GM rice plants developed from this T-DNA were resistant to lepidopteran pests and tolerant to glyphosate, but sensitive to bentazon. The application of bentazon of 2000 mg/L at the rate of 40 mL/m(2), which is approximately the recommended dose for the field application to control common rice weeds, killed all F(2) plants containing the transgenes generated from the Crop-weed hybrids between a GM rice line (CGH-13) and two weedy rice strains (PI-63 and PI-1401). Weedy rice plants containing transgenes from GM rice through gene flow can be selectively killed by the spray of bentazon when a non-GM rice variety is cultivated alternately in a few-year interval. The built-in control mechanism in combination of cropping management is likely to mitigate the spread of transgenes into weedy rice populations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bateman, V.I.; Brown, F.A.; Hansen, N.R.

Sandia National Laboratories (SNL) designs mechanical systems with electronics that must survive high shock environments. These mechanical systems include penetrators that must survive soil, rock, and ice penetration, nuclear transportation casks that must survive transportation environments, and laydown weapons that must survive delivery impact of 125 fps. These mechanical systems contain electronics that may operate during and after the high shock environment and that must be protected from the high shock environments. A study has been started to improve the packaging techniques for the advanced electronics utilized in these mechanical systems because current packaging techniques are inadequate for these moremore » sensitive electronics. In many cases, it has been found that the packaging techniques currently used not only do not mitigate the shock environment but actually amplify the shock environment. An ambitious goal for this packaging study is to avoid amplification and possibly attenuate the shock environment before it reaches the electronics contained in the various mechanical systems. As part of the investigation of packaging techniques, a two phase study of shock mitigating materials is being conducted. The purpose of the first phase reported here is to examine the performance of a joint that consists of shock mitigating material sandwiched in between steel and to compare the performance of the shock mitigating materials. A split Hopkinson bar experimental configuration simulates this joint and has been used to study the shock mitigating characteristics of seventeen, unconfined materials. The nominal input for these tests is an incident compressive wave with 50 fps peak (1,500 {micro}{var_epsilon} peak) amplitude and a 100 {micro}s duration (measured at 10% amplitude).« less

Interference Mitigation for Cyber-Physical Wireless Body Area Network System Using Social Networks

PubMed Central

Zhang, Zhaoyang; Wang, Honggang; Wang, Chonggang; Fang, Hua

2014-01-01

Wireless body area networks (WBANs) are cyber-physical systems (CPS) that have emerged as a key technology to provide real-time health monitoring and ubiquitous healthcare services. WBANs could operate in dense environments such as in a hospital and lead to a high mutual communication interference in many application scenarios. The excessive interferences will significantly degrade the network performance including depleting the energy of WBAN nodes more quickly, and even eventually jeopardize people’s lives due to unreliable (caused by the interference) healthcare data collections. Therefore, It is critical to mitigate the interference among WBANs to increase the reliability of the WBAN system while minimizing the system power consumption. Many existing approaches can deal with communication interference mitigation in general wireless networks but are not suitable for WBANs due to their ignoring the social nature of WBANs. Unlike the previous research, we for the first time propose a power game based approach to mitigate the communication interferences for WBANs based on the people’s social interaction information. Our major contributions include: (1) model the inter-WBANs interference, and determine the distance distribution of the interference through both theoretical analysis and Monte Carlo simulations; (2) develop social interaction detection and prediction algorithms for people carrying WBANs; (3) develop a power control game based on the social interaction information to maximize the system’s utility while minimize the energy consumption of WBANs system. The extensive simulation results show the effectiveness of the power control game for inter-WBAN interference mitigation using social interaction information. Our research opens a new research vista of WBANs using social networks. PMID:25436180

New Developments in FPGA: SEUs and Fail-Safe Strategies from the NASA Goddard Perspective

NASA Technical Reports Server (NTRS)

Berg, Melanie D.; Label, Kenneth A.; Pellish, Jonathan

2016-01-01

It has been shown that, when exposed to radiation environments, each Field Programmable Gate Array (FPGA) device has unique error signatures. Subsequently, fail-safe and mitigation strategies will differ per FPGA type. In this session several design approaches for safe systems will be presented. It will also explore the benefits and limitations of several mitigation techniques. The intention of the presentation is to provide information regarding FPGA types, their susceptibilities, and proven fail-safe strategies; so that users can select appropriate mitigation and perform the required trade for system insertion. The presentation will describe three types of FPGA devices and their susceptibilities in radiation environments.

New Developments in FPGA: SEUs and Fail-Safe Strategies from the NASA Goddard Perspective

NASA Technical Reports Server (NTRS)

Berg, Melanie D.; LaBel, Kenneth; Pellish, Jonathan

2015-01-01

It has been shown that, when exposed to radiation environments, each Field Programmable Gate Array (FPGA) device has unique error signatures. Subsequently, fail-safe and mitigation strategies will differ per FPGA type. In this session several design approaches for safe systems will be presented. It will also explore the benefits and limitations of several mitigation techniques. The intention of the presentation is to provide information regarding FPGA types, their susceptibilities, and proven fail-safe strategies; so that users can select appropriate mitigation and perform the required trade for system insertion. The presentation will describe three types of FPGA devices and their susceptibilities in radiation environments.

Fabrication of spherical mitigation pit on KH2PO4 crystal by micro-milling and modeling of its induced light intensification.

PubMed

Cheng, Jian; Chen, Mingjun; Liao, Wei; Wang, Haijun; Xiao, Yong; Li, Mingquan

2013-07-15

Micro-machining is the most promising method for KH(2)PO(4) crystal to mitigate the surface damage growth in high power laser system. In this work, spherical mitigation pit is fabricated by micro-milling with an efficient machining procedure. The light intensification caused by rear surface features before and after mitigation is numerically modeled based on the finite-difference time-domain method. The results indicate that the occurrence of total internal reflections should be responsible for the largest light intensification inside the crystal. For spherical pits after mitigation, the light intensification can be greatly alleviated by preventing the occurrence of total internal reflections. The light intensification caused by spherical mitigation pit is strongly dependent on the width-depth ratio and it is suggested that the width-depth ratio of spherical mitigation pit must be devised to be larger than 5.0 to achieve the minimal light intensification for the mitigation of surface damage growth. Laser damage tests for KH(2)PO(4) crystal validate that the laser damage resistance of initially damaged surface can be retrieved to near the level of ideal surface by replacing initial damage site with predesigned mitigation pit.

Mitigation of Hot-Spots in Photovoltaic Systems Using Distributed Power Electronics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olalla, Carlos; Hasan, Md. Nazmul; Deline, Chris

In the presence of partial shading and other mismatch factors, bypass diodes may not offer complete elimination of excessive power dissipation due to cell reverse biasing, commonly referred to as hot-spotting in photovoltaic (PV) systems. As a result, PV systems may experience higher failure rates and accelerated ageing. In this paper, a cell-level simulation model is used to assess occurrence of hot-spotting events in a representative residential rooftop system scenario featuring a moderate shading environment. The approach is further used to examine how well distributed power electronics converters mitigate the effects of partial shading and other sources of mismatch bymore » preventing activation of bypass diodes and thereby reducing the chances of heavy power dissipation and hot-spotting in mismatched cells. The simulation results confirm that the occurrence of heavy power dissipation is reduced in all distributed power electronics architectures, and that submodule-level converters offer nearly 100% mitigation of hot-spotting. In addition, the paper further elaborates on the possibility of hot-spot-induced permanent damage, predicting a lifetime energy loss above 15%. In conclusion, this energy loss is fully recoverable with submodule-level power converters that mitigate hot-spotting and prevent the damage.« less

Mitigation of Hot-Spots in Photovoltaic Systems Using Distributed Power Electronics

DOE PAGES

Olalla, Carlos; Hasan, Md. Nazmul; Deline, Chris; ...

2018-03-23

In the presence of partial shading and other mismatch factors, bypass diodes may not offer complete elimination of excessive power dissipation due to cell reverse biasing, commonly referred to as hot-spotting in photovoltaic (PV) systems. As a result, PV systems may experience higher failure rates and accelerated ageing. In this paper, a cell-level simulation model is used to assess occurrence of hot-spotting events in a representative residential rooftop system scenario featuring a moderate shading environment. The approach is further used to examine how well distributed power electronics converters mitigate the effects of partial shading and other sources of mismatch bymore » preventing activation of bypass diodes and thereby reducing the chances of heavy power dissipation and hot-spotting in mismatched cells. The simulation results confirm that the occurrence of heavy power dissipation is reduced in all distributed power electronics architectures, and that submodule-level converters offer nearly 100% mitigation of hot-spotting. In addition, the paper further elaborates on the possibility of hot-spot-induced permanent damage, predicting a lifetime energy loss above 15%. In conclusion, this energy loss is fully recoverable with submodule-level power converters that mitigate hot-spotting and prevent the damage.« less

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.

PubMed

Wang, Chun-Yan; Xu, Ye; Wang, Xu; Guo, Chuang; Wang, Tao; Wang, Zhan-You

2018-04-25

Oxidative stress and neuroinflammation play important roles in the pathology of Alzheimer's disease (AD). Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin, is suspected to be an important modulator of oxidative stress and inflammation. However, the underlying mechanism involved in the abnormal homeostasis of TXNIP-thioredoxin (TrX) in AD pathogenesis remains unclear. Using the Swedish mutant form of APP (APPswe)/PSEN1dE9 transgenic mouse (APP/PS1) and human-derived neuronal cells as model systems, we disclosed the impairment of the nuclear factor erythroid 2-related factor 2 (Nrf2)-TXNIP-TrX signaling in Alzheimer's-like pathology. We observed that the immune staining of TXNIP was increased in postmortem AD brain. The chronic accumulation of inflammatory mediator in neuronal cells facilitates interactions of TXNIP-nucleotide binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) and NLRP3-ASC, which increases β-amyloid (Aβ) secretion. The antioxidant Dl-3-n-butylphthalide (Dl-NBP) is commonly used for cerebral ischemia treatment. In our study, we elucidated for new mechanisms by which Dl-NBP enhanced TrX activity, suppressed TXNIP, and ameliorated neuronal apoptosis in the APP/PS1 mouse brains. In human glioblastoma A172 cells and neuroblastoma SH-SY5Y cells, we delineated the Dl-NBP-mediated signaling pathways by which Dl-NBP-dependent upregulation of Nrf2 mediated the reciprocal regulation of reducing proinflammatory cytokine and inhibiting Aβ production in the glial and neuronal cells overexpressing APPswe. Our data provide a novel insight into the molecular mechanism that impairments of Nrf2-TXNIP-TrX system may be involved in the imbalance of cellular redox homeostasis and inflammatory damage in the AD brain. Dl-NBP treatment could suppress TXNIP-NLRP3 interaction and inhibit NLRP3 inflammasome activation via upregulating Nrf2. These findings may provide an instrumental therapeutic approach for AD. Antioxid. Redox Signal. 00, 000-000.

Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis

PubMed Central

Miller, Omer; Butovsky, Oleg; Bukshpan, Shay; Beers, David R.; Henkel, Jenny S.; Yoles, Eti; Appel, Stanley H.; Schwartz, Michal

2011-01-01

Background Circulating immune cells including autoreactive T cells and monocytes have been documented as key players in maintaining, protecting and repairing the central nervous system (CNS) in health and disease. Here, we hypothesized that neurodegenerative diseases might be associated, similarly to tumors, with increased levels of circulating peripheral myeloid derived suppressor cells (MDSCs), representing a subset of suppressor cells that often expand under pathological conditions and inhibit possible recruitment of helper T cells needed for fighting off the disease. Methods and Findings We tested this working hypothesis in amyotrophic lateral sclerosis (ALS) and its mouse model, which are characterized by a rapid progression once clinical symptoms are evident. Adaptive transfer of alternatively activated myeloid (M2) cells, which homed to the spleen and exhibited immune suppressive activity in G93A mutant superoxide dismutase-1 (mSOD1) mice at a stage before emergence of disease symptoms, resulted in earlier appearance of disease symptoms and shorter life expectancy. The same protocol mitigated the inflammation-induced disease model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), which requires circulating T cells for disease induction. Analysis of whole peripheral blood samples obtained from 28 patients suffering from sporadic ALS (sALS), revealed a two-fold increase in the percentage of circulating MDSCs (LIN−/LowHLA-DR−CD33+) compared to controls. Conclusions Taken together, these results emphasize the distinct requirements for fighting the inflammatory neurodegenerative disease, multiple sclerosis, and the neurodegenerative disease, ALS, though both share a local inflammatory component. Moreover, the increased levels of circulating MDSCs in ALS patients indicates the operation of systemic mechanisms that might lead to an impairment of T cell reactivity needed to overcome the disease conditions within the CNS. This high level of suppressive immune cells might represent a risk factor and a novel target for therapeutic intervention in ALS at least at the early stage. PMID:22073221

Aero-acoustic design and test of a multiple splitter exhaust noise suppressor for a 0.914m diameter lift fan

NASA Technical Reports Server (NTRS)

Stimpert, D. L.

1973-01-01

A lift fan exhaust suppression system to meet future VTOL aircraft noise goals was designed and tested. The test vehicle was a 1.3 pressure ratio, 36 inch (91.44 cm) diameter lift fan with two chord rotor to stator spacing. A two splitter fan exhaust suppression system thirty inches (76.2 cm) long achieved 10 PNdB exhaust suppression in the aft quadrant compared to a design value of 20 PNdB. It was found that a broadband noise floor limited the realizable suppression. An analytical investigation of broadband noise generated by flow over the treatment surfaces provided very good agreement with the measured suppression levels and noise floor sound power levels. A fan thrust decrement of 22% was measured for the fully suppressed configuration of which 11.1% was attributed to the exhaust suppression hardware.

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity

PubMed Central

Zha, Weibin; Edin, Matthew L.; Vendrov, Kimberly C.; Schuck, Robert N.; Lih, Fred B.; Jat, Jawahar Lal; Bradbury, J. Alyce; DeGraff, Laura M.; Hua, Kunjie; Tomer, Kenneth B.; Falck, John R.; Zeldin, Darryl C.; Lee, Craig R.

2014-01-01

Adipogenesis plays a critical role in the initiation and progression of obesity. Although cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have emerged as a potential therapeutic target for cardiometabolic disease, the functional contribution of EETs to adipogenesis and the pathogenesis of obesity remain poorly understood. Our studies demonstrated that induction of adipogenesis in differentiated 3T3-L1 cells (in vitro) and obesity-associated adipose expansion in high-fat diet (HFD)-fed mice (in vivo) significantly dysregulate the CYP epoxygenase pathway and evoke a marked suppression of adipose-derived EET levels. Subsequent in vitro experiments demonstrated that exogenous EET analog administration elicits potent anti-adipogenic effects via inhibition of the early phase of adipogenesis. Furthermore, EET analog administration to mice significantly mitigated HFD-induced weight gain, adipose tissue expansion, pro-adipogenic gene expression, and glucose intolerance. Collectively, these findings suggest that suppression of EET bioavailability in adipose tissue is a key pathological consequence of obesity, and strategies that promote the protective effects of EETs in adipose tissue offer enormous therapeutic potential for obesity and its downstream pathological consequences. PMID:25114171

Silicon Nano-tips and Related Nano-Systems Involving Fluid and Carrier Transport for Miniaturized Spacecraft Power and Sensing Applications

DTIC Science & Technology

2015-02-02

the nanoscale. Through this research, the two fundamental life-limiting issues of ILIS operation have been identified and mitigated: electrochemical ...this research, the two fundamental life-limiting issues of ILIS operation have been identified and mitigated: electrochemical degradation and gas...identified and mitigated: electrochemical degradation and gas discharges. A distal electrode configuration was proposed and verified as a strategy

Operational Decision Aids for Exploiting or Mitigating Electromagnetic Propagation Effects

DTIC Science & Technology

1989-09-01

Exploitation or mitigation of environmental effects rank equal in importance with weapons systems. The rapidly changing propagation environment ...global in nature . It not only involves the ocean environment from the tropics to the poles, but also the coastal and land environments . Some of the...tactics must take environ - mental conditions into account and either mitigate or exploit their effects. There are many environmental factors that influence

Assessment and Mitigation of Electromagnetic Pulse (EMP) Impacts at Short-pulse Laser Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Jr., C G; Bond, E; Clancy, T

2009-10-02

The National Ignition Facility (NIF) will be impacted by electromagnetic pulse (EMP) during normal long-pulse operation, but the largest impacts are expected during short-pulse operation utilizing the Advanced Radiographic Capability (ARC). Without mitigation these impacts could range from data corruption to hardware damage. We describe our EMP measurement systems on Titan and NIF and present some preliminary results and thoughts on mitigation.

Assessment and Mitigation of Electromagnetic Pulse (EMP) Impacts at Short-pulse Laser Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Jr., C G; Bond, E; Clancy, T

2010-02-04

The National Ignition Facility (NIF) will be impacted by electromagnetic pulse (EMP) during normal long-pulse operation, but the largest impacts are expected during short-pulse operation utilizing the Advanced Radiographic Capability (ARC). Without mitigation these impacts could range from data corruption to hardware damage. We describe our EMP measurement systems on Titan and NIF and present some preliminary results and thoughts on mitigation.

GIS as a vital tool for Environmental Impact Assessment and Mitigation

NASA Astrophysics Data System (ADS)

Gharehbaghi, Koorosh; Scott-Young, Christina

2018-03-01

Environmental Impact Assessment (EIA) is a course of action which provides information to various stakeholders such as planners and relevant authorities about the planned development and its subsequent effects of the environment and the immediate ambiances. Furthermore, the EIA and mitigation are the inclusive process of collecting, analyzing information and the determination of the application for development or construction approval, which could be accessible by the concerned communities and organizations. Although the set regulations of EIA and mitigation vary from jurisdictions, they are, however, very precise and need to be integrated with the specific geographical data. In addition, the Geographical Information System (GIS) is a software intended to encapsulate and present all types of physical, biological, environmental, ecological and geological information. Conversely, GIS is the integration of statistical analysis and information technology, and can also be further broken down into two different categories of; Topological Modelling and Map overlay. To ensure that the EIA and mitigation are receptive the GIS will provide the decisive apparatus. Using GIS not only improves the overall EIA and mitigation process, but also provides valuable mapping strategies, including holistic environmental system approach. Accordingly, the main objective of this paper is to discuss the importance of the GIS and Environmental Data integration progression, to further enhance the overall EIA and Mitigation processes.

The Multi-Parameter Wireless Sensing System (MPwise): Its Description and Application to Earthquake Risk Mitigation.

PubMed

Boxberger, Tobias; Fleming, Kevin; Pittore, Massimiliano; Parolai, Stefano; Pilz, Marco; Mikulla, Stefan

2017-10-20

The Multi-Parameter Wireless Sensing (MPwise) system is an innovative instrumental design that allows different sensor types to be combined with relatively high-performance computing and communications components. These units, which incorporate off-the-shelf components, can undertake complex information integration and processing tasks at the individual unit or node level (when used in a network), allowing the establishment of networks that are linked by advanced, robust and rapid communications routing and network topologies. The system (and its predecessors) was originally designed for earthquake risk mitigation, including earthquake early warning (EEW), rapid response actions, structural health monitoring, and site-effect characterization. For EEW, MPwise units are capable of on-site, decentralized, independent analysis of the recorded ground motion and based on this, may issue an appropriate warning, either by the unit itself or transmitted throughout a network by dedicated alarming procedures. The multi-sensor capabilities of the system allow it to be instrumented with standard strong- and weak-motion sensors, broadband sensors, MEMS (namely accelerometers), cameras, temperature and humidity sensors, and GNSS receivers. In this work, the MPwise hardware, software and communications schema are described, as well as an overview of its possible applications. While focusing on earthquake risk mitigation actions, the aim in the future is to expand its capabilities towards a more multi-hazard and risk mitigation role. Overall, MPwise offers considerable flexibility and has great potential in contributing to natural hazard risk mitigation.

The Multi-Parameter Wireless Sensing System (MPwise): Its Description and Application to Earthquake Risk Mitigation

PubMed Central

Boxberger, Tobias; Fleming, Kevin; Pittore, Massimiliano; Parolai, Stefano; Pilz, Marco; Mikulla, Stefan

2017-01-01

The Multi-Parameter Wireless Sensing (MPwise) system is an innovative instrumental design that allows different sensor types to be combined with relatively high-performance computing and communications components. These units, which incorporate off-the-shelf components, can undertake complex information integration and processing tasks at the individual unit or node level (when used in a network), allowing the establishment of networks that are linked by advanced, robust and rapid communications routing and network topologies. The system (and its predecessors) was originally designed for earthquake risk mitigation, including earthquake early warning (EEW), rapid response actions, structural health monitoring, and site-effect characterization. For EEW, MPwise units are capable of on-site, decentralized, independent analysis of the recorded ground motion and based on this, may issue an appropriate warning, either by the unit itself or transmitted throughout a network by dedicated alarming procedures. The multi-sensor capabilities of the system allow it to be instrumented with standard strong- and weak-motion sensors, broadband sensors, MEMS (namely accelerometers), cameras, temperature and humidity sensors, and GNSS receivers. In this work, the MPwise hardware, software and communications schema are described, as well as an overview of its possible applications. While focusing on earthquake risk mitigation actions, the aim in the future is to expand its capabilities towards a more multi-hazard and risk mitigation role. Overall, MPwise offers considerable flexibility and has great potential in contributing to natural hazard risk mitigation. PMID:29053608

Co-Optima Highlights Primary Causes of Misfueling and Mitigation Strategies

Science.gov Websites

% ethanol; 90% unleaded gasoline) for use in any gasoline vehicle. Many misfueling mitigation measures such lead to vehicle systems damage. Measures such as nozzle colors are not universally standardized. Fuel

Flutter suppression for the Active Flexible Wing - Control system design and experimental validation

NASA Technical Reports Server (NTRS)

Waszak, M. R.; Srinathkumar, S.

1992-01-01

The synthesis and experimental validation of a control law for an active flutter suppression system for the Active Flexible Wing wind-tunnel model is presented. The design was accomplished with traditional root locus and Nyquist methods using interactive computer graphics tools and with extensive use of simulation-based analysis. The design approach relied on a fundamental understanding of the flutter mechanism to formulate understanding of the flutter mechanism to formulate a simple control law structure. Experimentally, the flutter suppression controller succeeded in simultaneous suppression of two flutter modes, significantly increasing the flutter dynamic pressure despite errors in the design model. The flutter suppression controller was also successfully operated in combination with a rolling maneuver controller to perform flutter suppression during rapid rolling maneuvers.

System performance enhancement with pre-distorted OOFDM signal waveforms in DM/DD systems.

PubMed

Sánchez, C; Ortega, B; Capmany, J

2014-03-24

In this work we propose a pre-distortion technique for the mitigation of the nonlinear distortion present in directly modulated/detected OOFDM systems and explore the system performance achieved under varying system parameters. Simulation results show that the proposed pre-distortion technique efficiently mitigates the nonlinear distortion, achieving transmission information rates around 40 Gbits/s and 18.5 Gbits/s over 40 km and 100 km of single mode fiber links, respectively, under optimum operating conditions. Moreover, the proposed pre-distortion technique can potentially provide higher system performance to that obtained with nonlinear equalization at the receiver.

Anti-disturbance rapid vibration suppression of the flexible aerial refueling hose

NASA Astrophysics Data System (ADS)

Su, Zikang; Wang, Honglun; Li, Na

2018-05-01

As an extremely dangerous phenomenon in autonomous aerial refueling (AAR), the flexible refueling hose vibration caused by the receiver aircraft's excessive closure speed should be suppressed once it appears. This paper proposed a permanent magnet synchronous motor (PMSM) based refueling hose servo take-up system for the vibration suppression of the flexible refueling hose. A rapid back-stepping based anti-disturbance nonsingular fast terminal sliding mode (NFTSM) control scheme with a specially established finite-time convergence NFTSM observer is proposed for the PMSM based hose servo take-up system under uncertainties and disturbances. The unmeasured load torque and other disturbances in the PMSM system are reconstituted by the NFTSM observer and to be compensated during the controller design. Then, with the back-stepping technique, a rapid anti-disturbance NFTSM controller is proposed for the PMSM angular tracking to improve the tracking error convergence speed and tracking precision. The proposed vibration suppression scheme is then applied to PMSM based hose servo take-up system for the refueling hose vibration suppression in AAR. Simulation results show the proposed scheme can suppress the hose vibration rapidly and accurately even the system is exposed to strong uncertainties and probe position disturbances, it is more competitive in tracking accuracy, tracking error convergence speed and robustness.

A feasibility study: California Department of Forestry and Fire Protection utilization of infrared technologies for wildland fire suppression and management

NASA Technical Reports Server (NTRS)

Nichols, J. D.; Britten, R. A.; Parks, G. S.; Voss, J. M.

1990-01-01

NASA's JPL has completed a feasibility study using infrared technologies for wildland fire suppression and management. The study surveyed user needs, examined available technologies, matched the user needs with technologies, and defined an integrated infrared wildland fire mapping concept system configuration. System component trade-offs were presented for evaluation in the concept system configuration. The economic benefits of using infrared technologies in fire suppression and management were examined. Follow-on concept system configuration development and implementation were proposed.

Construction and measurements of an improved vacuum-swing-adsorption radon-mitigation system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Street, J., E-mail: joseph.street@mines.sdsmt.edu; Bunker, R.; Dunagan, C.

In order to reduce backgrounds from radon-daughter plate-out onto detector surfaces, an ultra-low-radon cleanroom is being commissioned at the South Dakota School of Mines and Technology. An improved vacuum-swing-adsorption radon mitigation system and cleanroom build upon a previous design implemented at Syracuse University that achieved radon levels of ∼0.2 Bq m{sup −3}. This improved system will employ a better pump and larger carbon beds feeding a redesigned cleanroom with an internal HVAC unit and aged water for humidification. With the rebuilt (original) radon mitigation system, the new low-radon cleanroom has already achieved a > 300× reduction from an input activitymore » of 58.6 ± 0.7 Bq m{sup −3} to a cleanroom activity of 0.13 ± 0.06 Bq m{sup −3}.« less

Life-cycle energy production and emissions mitigation by comprehensive biogas-digestate utilization.

PubMed

Chen, Shaoqing; Chen, Bin; Song, Dan

2012-06-01

In the context of global energy shortages and climate change, developing biogas plants with links to agricultural system has become an important strategy for cleaner rural energy and renewable agriculture. In this study, a life-cycle energy and environmental assessment was performed for a biogas-digestate utilization system in China. The results suggest that biogas utilization (heating, illumination, and fuel) and comprehensive digestate reuse are of equal importance in the total energy production of the system, and they also play an important role in systemic greenhouse gas mitigation. Improvement can be achieved in both energy production and emissions mitigation when the ratio of the current three biogas utilization pathways is adjusted. Regarding digestate reuse, a tradeoff between energy and environmental performance can be obtained by focusing on the substitution for top-dressing, base fertilizers, and the application to seed soaking. Copyright © 2012 Elsevier Ltd. All rights reserved.

A robust control strategy for mitigating renewable energy fluctuations in a real hybrid power system combined with SMES

NASA Astrophysics Data System (ADS)

Magdy, G.; Shabib, G.; Elbaset, Adel A.; Qudaih, Yaser; Mitani, Yasunori

2018-05-01

Utilizing Renewable Energy Sources (RESs) is attracting great attention as a solution to future energy shortages. However, the irregular nature of RESs and random load deviations cause a large frequency and voltage fluctuations. Therefore, in order to benefit from a maximum capacity of the RESs, a robust mitigation strategy of power fluctuations from RESs must be applied. Hence, this paper proposes a design of Load Frequency Control (LFC) coordinated with Superconducting Magnetic Energy Storage (SMES) technology (i.e., an auxiliary LFC), using an optimal PID controller-based Particle Swarm Optimization (PSO) in the Egyptian Power System (EPS) considering high penetration of Photovoltaics (PV) power generation. Thus, from the perspective of LFC, the robust control strategy is proposed to maintain the nominal system frequency and mitigating the power fluctuations from RESs against all disturbances sources for the EPS with the multi-source environment. The EPS is decomposed into three dynamics subsystems, which are non-reheat, reheat and hydro power plants taking into consideration the system nonlinearity. The results by nonlinear simulation Matlab/Simulink for the EPS combined with SMES system considering PV solar power approves that, the proposed control strategy achieves a robust stability by reducing transient time, minimizing the frequency deviations, maintaining the system frequency, preventing conventional generators from exceeding their power ratings during load disturbances, and mitigating the power fluctuations from the RESs.

Social and ethical perspectives of landslide risk mitigation measures

NASA Astrophysics Data System (ADS)

Kalsnes, Bjørn; Vangelsten, Bjørn V.

2015-04-01

Landslide risk may be mitigated by use of a wide range of measures. Mitigation and prevention options may include (1) structural measures to reduce the frequency, severity or exposure to the hazard, (2) non-structural measures, such as land-use planning and early warning systems, to reduce the hazard frequency and consequences, and (3) measures to pool and transfer the risks. In a given situation the appropriate system of mitigation measures may be a combination of various types of measures, both structural and non-structural. In the process of choosing mitigation measures for a given landslide risk situation, the role of the geoscientist is normally to propose possible mitigation measures on basis of the risk level and technical feasibility. Social and ethical perspectives are often neglected in this process. However, awareness of the need to consider social as well as ethical issues in the design and management of mitigating landslide risk is rising. There is a growing understanding that technical experts acting alone cannot determine what will be considered the appropriate set of mitigation and prevention measures. Issues such as environment versus development, questions of acceptable risk, who bears the risks and benefits, and who makes the decisions, also need to be addressed. Policymakers and stakeholders engaged in solving environmental risk problems are increasingly recognising that traditional expert-based decision-making processes are insufficient. This paper analyse the process of choosing appropriate mitigation measures to mitigate landslide risk from a social and ethical perspective, considering technical, cultural, economical, environmental and political elements. The paper focus on stakeholder involvement in the decision making process, and shows how making strategies for risk communication is a key for a successful process. The study is supported by case study examples from Norway and Italy. In the Italian case study, three different risk mitigation options was presented to the local community. The options were based on a thorough stakeholder involvement process ending up in three different views on how to deal with the landslide risk situation: i) protect lives and properties (hierarchical) ; ii) careful stewardship of the mountains (egalitarian); and iii) rational individual choice (individualist).

The Medical Duty Officer: An Attempt to Mitigate the Ambulance At-Hospital Interval

PubMed Central

Halliday, Megan H.; Bouland, Andrew J.; Lawner, Benjamin J.; Comer, Angela C.; Ramos, Daniel C.; Fletcher, Mark

2016-01-01

Introduction A lack of coordination between emergency medical services (EMS), emergency departments (ED) and systemwide management has contributed to extended ambulance at-hospital times at local EDs. In an effort to improve communication within the local EMS system, the Baltimore City Fire Department (BCFD) placed a medical duty officer (MDO) in the fire communications bureau. It was hypothesized that any real-time intervention suggested by the MDO would be manifested in a decrease in the EMS at-hospital time. Methods The MDO was implemented on November 11, 2013. A senior EMS paramedic was assigned to the position and was placed in the fire communication bureau from 9 a.m. to 9 p.m., seven days a week. We defined the pre-intervention period as August 2013 – October 2013 and the post-intervention period as December 2013 – February 2014. We also compared the post-intervention period to the “seasonal match control” one year earlier to adjust for seasonal variation in EMS volume. The MDO was tasked with the prospective management of city EMS resources through intensive monitoring of unit availability and hospital ED traffic. The MDO could suggest alternative transport destinations in the event of ED crowding. We collected and analyzed data from BCFD computer-aided dispatch (CAD) system for the following: ambulance response times, ambulance at-hospital interval, hospital diversion and alert status, and “suppression wait time” (defined as the total time suppression units remained on scene until ambulance arrival). The data analysis used a pre/post intervention design to examine the MDO impact on the BCFD EMS system. Results There were a total of 15,567 EMS calls during the pre-intervention period, 13,921 in the post-intervention period and 14,699 in the seasonal match control period one year earlier. The average at-hospital time decreased by 1.35 minutes from pre- to post-intervention periods and 4.53 minutes from the pre- to seasonal match control, representing a statistically significant decrease in this interval. There was also a statistically significant decrease in hospital alert time (approximately 1,700 hour decrease pre- to post-intervention periods) and suppression wait time (less than one minute decrease from pre- to post- and pre- to seasonal match control periods). The decrease in ambulance response time was not statistically significant. Conclusion Proactive deployment of a designated MDO was associated with a small, contemporaneous reduction in at-hospital time within an urban EMS jurisdiction. This project emphasized the importance of better communication between EMS systems and area hospitals as well as uniform reporting of variables for future iterations of this and similar projects. PMID:27625737

Mitigation of methane emissions in cities: How new measurements and partnerships can contribute to emissions reduction strategies

DOE PAGES

Hopkins, Francesca M.; Ehleringer, James R.; Bush, Susan E.; ...

2016-09-10

Cities generate 70% of anthropogenic greenhouse gas emissions, a fraction that is grow-ing with global urbanization. While cities play an important role in climate change mitigation, there has been little focus on reducing urban methane (CH4) emissions. Here, we develop a conceptual framework for CH 4 mitigation in cities by describing emission processes, the role of measurements, and a need for new institutional partnerships. Urban CH 4 emissions are likely to grow with expanding use of natural gas and organic waste disposal systems in growing population centers; however, we currently lack the ability to quantify this increase. We also lackmore » systematic knowledge of the relative contribution of these distinct source sectors on emissions. We present new observations from four North American cities to demonstrate that CH4 emissions vary in magnitude and sector from city to city and hence require different mitigation strategies. Detections of fugitive emissions from these systems suggest that current mitiga- tion approaches are absent or ineffective. These findings illustrate that tackling urban CH 4 emissions will require research efforts to identify mitigation targets, develop and implement new mitigation strategies, and monitor atmospheric CH 4 levels to ensure the success of mitigation efforts. This research will require a variety of techniques to achieve these objectives and should be deployed in cities globally. In conclusion, we suggest that metropolitan scale partnerships may effectively coordinate systematic measurements and actions focused on emission reduction goals.« less

Mitigation of methane emissions in cities: How new measurements and partnerships can contribute to emissions reduction strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, Francesca M.; Ehleringer, James R.; Bush, Susan E.

Cities generate 70% of anthropogenic greenhouse gas emissions, a fraction that is grow-ing with global urbanization. While cities play an important role in climate change mitigation, there has been little focus on reducing urban methane (CH4) emissions. Here, we develop a conceptual framework for CH 4 mitigation in cities by describing emission processes, the role of measurements, and a need for new institutional partnerships. Urban CH 4 emissions are likely to grow with expanding use of natural gas and organic waste disposal systems in growing population centers; however, we currently lack the ability to quantify this increase. We also lackmore » systematic knowledge of the relative contribution of these distinct source sectors on emissions. We present new observations from four North American cities to demonstrate that CH4 emissions vary in magnitude and sector from city to city and hence require different mitigation strategies. Detections of fugitive emissions from these systems suggest that current mitiga- tion approaches are absent or ineffective. These findings illustrate that tackling urban CH 4 emissions will require research efforts to identify mitigation targets, develop and implement new mitigation strategies, and monitor atmospheric CH 4 levels to ensure the success of mitigation efforts. This research will require a variety of techniques to achieve these objectives and should be deployed in cities globally. In conclusion, we suggest that metropolitan scale partnerships may effectively coordinate systematic measurements and actions focused on emission reduction goals.« less

Implementing climate change mitigation in health services: the importance of context.

PubMed

Desmond, Sharon

2016-10-01

Academic interest in strategies to reduce the impact of health services on climate change is quickening. Research has largely focused on local innovations with little consideration of the contextual and systemic elements that influence sustainable development across health systems. A realistic framework specifically to guide decision-making by health care providers is still needed. To address this deficit, the literature is explored in relation to health services and climate change mitigation strategies, and the contextual factors that influence efforts to mitigate climate effects in health service delivery environments are highlighted. A conceptual framework is proposed that offers a model for the pursuit of sustainable development practice in health services. A set of propositions is advanced to provide a systems approach to assist decision-making by decoding the challenges faced in implementing sustainable health services. This has important implications for health care providers, funders and legislators since the financial, policy and regulatory environment of health care, along with its leadership and models of care generally conflict with carbon literacy and climate change mitigation strategies. © The Author(s) 2016.

Vibration mitigation in partially liquid-filled vessel using passive energy absorbers

NASA Astrophysics Data System (ADS)

Farid, M.; Levy, N.; Gendelman, O. V.

2017-10-01

We consider possible solutions for vibration mitigation in reduced-order model (ROM) of partially filled liquid tank under impulsive forcing. Such excitations may lead to strong hydraulic impacts applied to the tank inner walls. Finite stiffness of the tank walls is taken into account. In order to mitigate the dangerous internal stresses in the tank walls, we explore both linear (Tuned Mass Damper) and nonlinear (Nonlinear Energy Sink) passive vibration absorbers; mitigation performance in both cases is examined numerically. The liquid sloshing mass is modeled by equivalent mass-spring-dashpot system, which can both perform small-amplitude linear oscillations and hit the vessel walls. We use parameters of the equivalent mass-spring-dashpot system for a well-explored case of cylindrical tanks. The hydraulic impacts are modeled by high-power potential and dissipation functions. Critical location in the tank structure is determined and expression of the corresponding local mechanical stress is derived. We use finite element approach to assess the natural frequencies for specific system parameters. Numerical evaluation criteria are suggested to determine the energy absorption performance.

Neural circuits in the brain that are activated when mitigating criminal sentences.

PubMed

Yamada, Makiko; Camerer, Colin F; Fujie, Saori; Kato, Motoichiro; Matsuda, Tetsuya; Takano, Harumasa; Ito, Hiroshi; Suhara, Tetsuya; Takahashi, Hidehiko

2012-03-27

In sentencing guilty defendants, jurors and judges weigh 'mitigating circumstances', which create sympathy for a defendant. Here we use functional magnetic resonance imaging to measure neural activity in ordinary citizens who are potential jurors, as they decide on mitigation of punishment for murder. We found that sympathy activated regions associated with mentalising and moral conflict (dorsomedial prefrontal cortex, precuneus and temporo-parietal junction). Sentencing also activated precuneus and anterior cingulate cortex, suggesting that mitigation is based on negative affective responses to murder, sympathy for mitigating circumstances and cognitive control to choose numerical punishments. Individual differences on the inclination to mitigate, the sentence reduction per unit of judged sympathy, correlated with activity in the right middle insula, an area known to represent interoception of visceral states. These results could help the legal system understand how potential jurors actually decide, and contribute to growing knowledge about whether emotion and cognition are integrated sensibly in difficult judgments.

The theory, design, and operation of the suppressed carrier data-aided tracking receiver

NASA Technical Reports Server (NTRS)

Simon, M. K.; Springett, J. C.

1973-01-01

A viable, efficient, and easily mechanized carrier regenerating receiver for use in suppressed carrier-tracking system is described. The receiver referred to as a data-aided receiver (DAR) incorporates a data-aided loop (DAL) which provides the required carrier reference signal. The DAL employs the principle of decision feedback and as such is more efficient than other forms of suppressed carrier-tracking loops. The analysis, design, and implementation of the DAR are covered in detail. Performance comparisons and mechanization tradeoffs are made, wherever possible, with discrete carrier systems and other suppressed carrier systems presently in use. Experimental performance verification is given throughout in support of the theory presented.

Porous plug phase separator and superfluid film flow suppression system for the soft x-ray spectrometer onboard ASTRO-H

NASA Astrophysics Data System (ADS)

Ezoe, Yuichiro; Ishikawa, Kumi; Mitsuishi, Ikuyuki; Ohashi, Takaya; Mitsuda, Kazuhisa; Fujimoto, Ryuichi; Murakami, Masahide; Kanao, Kenichi; Yoshida, Seiji; Tsunematsu, Shoji; DiPirro, Michael; Shirron, Peter

2016-07-01

Suppression of super fluid helium flow is critical for the Soft X-ray Spectrometer onboard ASTRO-H (Hitomi). In nominal operation, a small helium gas flow of 30 μg/s must be safely vented and a super fluid film flow must be sufficiently small <2 μg/s. To achieve a life time of the liquid helium, a porous plug phase separator and a film flow suppression system composed of an orifice, a heat exchanger, and knife edge devices are employed. In this paper, design, on-ground testing results and in-orbit performance of the porous plug and the film flow suppression system are described.

Target crashes and safety benefits estimation methodology for pedestrian crash avoidance/mitigation systems

DOT National Transportation Integrated Search

2014-04-01

Through the analysis of national crash databases from the National Highway Traffic Safety Administration, pre-crash scenarios are identified, prioritized, and described for the development of objective tests for pedestrian crash avoidance/mitigation ...

CHARACTERIZING AND MITIGATING PATHOGENIC ORGANISMS RELATED TO CAFOS

EPA Science Inventory

CHARACTERIZING AND MITIGATING PATHOGENIC ORGANISMS RELATED TO CAFOs John Haines and Shane Rogers NRMRL Science Questions MYP Science Ouestion: What BMP treatment systems and restoration technologies are most effective options for watershed management? For mixed land use wa...

Supporting FIRE-suppression strategies combining fire spread MODelling and SATellite data in an operational context in Portugal: the FIRE-MODSAT project

NASA Astrophysics Data System (ADS)

Sá, Ana C. L.; Benali, Akli; Pinto, Renata M. S.; Pereira, José M. C.; Trigo, Ricardo M.; DaCamara, Carlos C.

2014-05-01

Large wildfires are infrequent but account for the most severe environmental, ecological and socio-economic impacts. In recent years Portugal has suffered the impact of major heat waves that fuelled records of burnt area exceeding 400.000ha and 300.000ha in 2003 and 2005, respectively. According to the latest IPCC reports, the frequency and amplitude of summer heat waves over Iberia will very likely increase in the future. Therefore, most climate change studies point to an increase in the number and extent of wildfires. Thus, an increase in both wildfire impacts and fire suppression difficulties is expected. The spread of large wildfires results from a complex interaction between topography, meteorology and fuel properties. Wildfire spread models (e.g. FARSITE) are commonly used to simulate fire growth and behaviour and are an essential tool to understand their main drivers. Additionally, satellite active-fire data have been used to monitor the occurrence, extent, and spread of wildfires. Both satellite data and fire spread models provide different types of information about the spatial and temporal distribution of large wildfires and can potentially be used to support strategic decisions regarding fire suppression resource allocation. However, they have not been combined in a manner that fully exploits their potential and minimizes their limitations. A knowledge gap still exists in understanding how to minimize the impacts of large wildfires, leading to the following research question: What can we learn from past large wildfires in order to mitigate future fire impacts? FIRE-MODSAT is a one-year funded project by the Portuguese Foundation for the Science and Technology (FCT) that is founded on this research question, with the main goal of improving our understanding on the interactions between fire spread and its environmental drivers, to support fire management decisions in an operational context and generate valuable information to improve the efficiency of the fire suppression system. This project proposes to explore an innovative combination of remote sensing and fire spread models in order to 1) better understand the interactions of fire spread drivers that lead to large wildfires; 2) identify the spatio-temporal frames in which large wildfires can be suppressed more efficiently, and 3) explore the essential steps towards an operational use of both tools to assist fire suppression decisions. Preliminary results combine MODIS active-fire data and burn scar perimeters, to derive the main fire spread paths for the 10 largest wildfires that occurred in Portugal between 2001 and 2012. Fire growth and behavior simulations of some of those wildfires are assessed using the active fires data. Results are also compared with the major fire paths to understand the main drivers of fire propagation, through their interactions with topography, vegetation and meteorology. These combined results are also used for spatial and temporal identification of opportunity windows for a more efficient suppression intervention for each fire event. The approach shows promising results, providing a valuable reconstruction of the fire events and retrieval of important parameters related to the complex spread patterns of individual fire events.

Evaporation from weighing precipitation gauges: impacts on automated gauge measurements and quality assurance methods

NASA Astrophysics Data System (ADS)

Leeper, R. D.; Kochendorfer, J.

2015-06-01

Evaporation from a precipitation gauge can cause errors in the amount of measured precipitation. For automated weighing-bucket gauges, the World Meteorological Organization (WMO) suggests the use of evaporative suppressants and frequent observations to limit these biases. However, the use of evaporation suppressants is not always feasible due to environmental hazards and the added cost of maintenance, transport, and disposal of the gauge additive. In addition, research has suggested that evaporation prior to precipitation may affect precipitation measurements from auto-recording gauges operating at sub-hourly frequencies. For further evaluation, a field campaign was conducted to monitor evaporation and its impacts on the quality of precipitation measurements from gauges used at U.S. Climate Reference Network (USCRN) stations. Two Geonor gauges were collocated, with one gauge using an evaporative suppressant (referred to as Geonor-NonEvap) and the other with no suppressant (referred to as Geonor-Evap) to evaluate evaporative losses and evaporation biases on precipitation measurements. From June to August, evaporative losses from the Geonor-Evap gauge exceeded accumulated precipitation, with an average loss of 0.12 mm h-1. The impact of evaporation on precipitation measurements was sensitive to the choice of calculation method. In general, the pairwise method that utilized a longer time series to smooth out sensor noise was more sensitive to gauge evaporation (-4.6% bias with respect to control) than the weighted-average method that calculated depth change over a smaller window (<+1% bias). These results indicate that while climate and gauge design affect gauge evaporation rates, computational methods also influence the magnitude of evaporation biases on precipitation measurements. This study can be used to advance quality insurance (QA) techniques used in other automated networks to mitigate the impact of evaporation biases on precipitation measurements.

Spinal Cord Excitability and Sprint Performance Are Enhanced by Sensory Stimulation During Cycling

PubMed Central

Pearcey, Gregory E. P.; Noble, Steven A.; Munro, Bridget; Zehr, E. Paul

2017-01-01

Spinal cord excitability, as assessed by modulation of Hoffmann (H-) reflexes, is reduced with fatiguing isometric contractions. Furthermore, spinal cord excitability is reduced during non-fatiguing arm and leg cycling. Presynaptic inhibition of Ia terminals is believed to contribute to this suppression of spinal cord excitability. Electrical stimulation to cutaneous nerves reduces Ia presynaptic inhibition, which facilitates spinal cord excitability, and this facilitation is present during arm cycling. Although it has been suggested that reducing presynaptic inhibition may prolong fatiguing contractions, it is unknown whether sensory stimulation can alter the effects of fatiguing exercise on performance or spinal cord excitability. Thus, the aim of this experiment was to determine if sensory stimulation can interfere with fatigue-related suppression of spinal cord excitability, and alter fatigue rates during cycling sprints. Thirteen participants randomly performed three experimental sessions that included: unloaded cycling with sensory stimulation (CONTROL + STIM), sprints with sensory stimulation (SPRINT + STIM) and sprints without stimulation (SPRINT). Seven participants also performed a fourth session (CONTROL), which consisted of unloaded cycling. During SPRINT and SPRINT + STIM, participants performed seven, 10 s cycling sprints interleaved with 3 min rest. For CONTROL and CONTROL + STIM, participants performed unloaded cycling for ~30 min. During SPRINT + STIM and CONTROL + STIM, participants received patterned sensory stimulation to nerves of the right foot. H-reflexes and M-waves of the right soleus were evoked by stimulation of the tibial nerve at multiple time points throughout exercise. Sensory stimulation facilitated soleus H-reflexes during unloaded cycling, whereas sprints suppressed soleus H-reflexes. While receiving sensory stimulation, there was less suppression of soleus H-reflexes and slowed reduction in average power output, compared to sprints without stimulation. These results demonstrate that sensory stimulation can substantially mitigate the fatiguing effects of sprints. PMID:29326570

Spinal Cord Excitability and Sprint Performance Are Enhanced by Sensory Stimulation During Cycling.

PubMed

Pearcey, Gregory E P; Noble, Steven A; Munro, Bridget; Zehr, E Paul

2017-01-01

Spinal cord excitability, as assessed by modulation of Hoffmann (H-) reflexes, is reduced with fatiguing isometric contractions. Furthermore, spinal cord excitability is reduced during non-fatiguing arm and leg cycling. Presynaptic inhibition of Ia terminals is believed to contribute to this suppression of spinal cord excitability. Electrical stimulation to cutaneous nerves reduces Ia presynaptic inhibition, which facilitates spinal cord excitability, and this facilitation is present during arm cycling. Although it has been suggested that reducing presynaptic inhibition may prolong fatiguing contractions, it is unknown whether sensory stimulation can alter the effects of fatiguing exercise on performance or spinal cord excitability. Thus, the aim of this experiment was to determine if sensory stimulation can interfere with fatigue-related suppression of spinal cord excitability, and alter fatigue rates during cycling sprints. Thirteen participants randomly performed three experimental sessions that included: unloaded cycling with sensory stimulation ( CONTROL + STIM ), sprints with sensory stimulation ( SPRINT + STIM ) and sprints without stimulation ( SPRINT ). Seven participants also performed a fourth session ( CONTROL ), which consisted of unloaded cycling. During SPRINT and SPRINT + STIM, participants performed seven, 10 s cycling sprints interleaved with 3 min rest. For CONTROL and CONTROL + STIM , participants performed unloaded cycling for ~30 min. During SPRINT + STIM and CONTROL + STIM , participants received patterned sensory stimulation to nerves of the right foot. H-reflexes and M-waves of the right soleus were evoked by stimulation of the tibial nerve at multiple time points throughout exercise. Sensory stimulation facilitated soleus H-reflexes during unloaded cycling, whereas sprints suppressed soleus H-reflexes. While receiving sensory stimulation, there was less suppression of soleus H-reflexes and slowed reduction in average power output, compared to sprints without stimulation. These results demonstrate that sensory stimulation can substantially mitigate the fatiguing effects of sprints.

Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury.

PubMed

Bi, Fangfang; Chen, Fang; Li, Yanning; Wei, Ai; Cao, Wangsen

2018-05-05

Renal anti-aging protein Klotho exhibits impressive properties of anti-inflammation and renal protection, however is suppressed early after renal injury, making Klotho restoration an attractive strategy of treating renal inflammatory disorders. Here, we reported that Klotho is enriched in macrophages and Klotho preservation by Rhein, an anthraquinone derived from medicinal plant rhubarb, attenuates lipopolysaccharide (LPS)-induced acute inflammation essentially via promoting toll-like receptor 4 (TLR4) degradation. LPS-induced pro-inflammatory NF-κB signaling and cytokine expressions coincided with Klotho repression and toll-like receptor 4 (TLR4) elevation in macrophages, renal epithelial cells, and acutely- inflamed kidney. Intriguingly, Rhein treatment effectively corrected the inverted alterations of Klotho and TLR4 and mitigated the TLR4 downstream inflammatory response in a Klotho restoration and TLR4 repression-dependent manner. Klotho inducibly associated with TLR4 after LPS stimulation and suppressed TLR4 protein abundance mainly via a proteolytic process sensitive to the inhibition of Klotho's putative β-glucuronidase activity. Consistently, Klotho knockdown by RNA interferences largely diminished the anti-inflammatory and renal protective effects of Rhein in a mouse model of acute kidney injury incurred by LPS. Thus, Klotho suppression of TLR4 via deglycosylation negatively controls TLR-associated inflammatory signaling and the endogenous Klotho preservation by Rhein or possibly other natural or synthetic compounds possesses promising potentials in the clinical treatment of renal inflammatory disorders. • Klotho is highly expressed in macrophages and repressed by LPS in vitro and in vivo. • Klotho inhibits LPS-induced TLR4 accumulation and the downstream signaling. • Klotho decreases TLR4 via a deglycosylation-associated proteolytic process. • Rhein effectively prevents acute inflammation-incurred Klotho suppression. • Rhein reversal of Klotho attenuates LPS-induced acute inflammation and kidney injury.

Pilot program (proof of concept) to mitigate Phytophthora ramorum at an infested nursery based on a systems approach

Treesearch

Gary Chastagner; Marianne Elliott

2017-01-01

The primary purpose of this program was to demonstrate proof of concept of certain mitigation approaches at a repeat P. ramorum-positive nursery site in Washington. Approaches included steam treatment of infested soil areas; creating a gravel “sandwich” above steam-treated and potentially infested soil surfaces; improving drainage systems; required...

Failure detection system risk reduction assessment

NASA Technical Reports Server (NTRS)

Aguilar, Robert B. (Inventor); Huang, Zhaofeng (Inventor)

2012-01-01

A process includes determining a probability of a failure mode of a system being analyzed reaching a failure limit as a function of time to failure limit, determining a probability of a mitigation of the failure mode as a function of a time to failure limit, and quantifying a risk reduction based on the probability of the failure mode reaching the failure limit and the probability of the mitigation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fraley, John J.; Marotz, Brian L.; DosSantos, Joseph M.

In this document we present fisheries losses, mitigation alternatives, and recommendations to protect, mitigate, and enhance resident fish and aquatic habitat affected by the construction and operation of Hungry Horse Dam. This plan addresses six separate program measures in the 1987 Columbia Basin Fish and Wildlife Program. We designed the plan to be closely coordinated in terms of dam operations, funding, and activities with the Kerr Mitigation Plan presently before the Federal Energy Regulatory Commission. This document represents a mitigation plan for consideration by the Northwest Power Planning Council process; it is not an implementation plan. Flathead Lake is onemore » of the cleanest lakes of its size in the world. The exceptional water quality and unique native fisheries make the Flathead Lake/River system extremely valuable to the economy and quality of life in the basin. The recreational fishery in Flathead Lake has an estimated value of nearly eight million dollars annually. This mitigation process represents our best opportunity to reduce the impacts of hydropower in this valuable aquatic system and increase angling opportunity. We based loss estimates and mitigation alternatives on an extensive data base, agency reports, nationally and internationally peer-reviewed scientific articles, and an innovative biological model for Hungry Horse Reservoir and the Flathead River. We conducted an extensive, 14-month scoping and consultation process with agency representatives, representatives of citizen groups, and the general public. This consultation process helped identify issues, areas of agreement, areas of conflict, and advantages and disadvantages of mitigation alternatives. The results of the scoping and consultation process helped shape our mitigation plan. Our recommended plan is based firmly on principles of adaptive management and recognition of biological uncertainty. After we receive direction from the NPPC, we will add more detailed hypotheses and other features necessary for a long-term implementation plan.« less

Current available strategies to mitigate greenhouse gas emissions in livestock systems: an animal welfare perspective.

PubMed

Llonch, P; Haskell, M J; Dewhurst, R J; Turner, S P

2017-02-01

Livestock production is a major contributor to greenhouse gas (GHG) emissions, so will play a significant role in the mitigation effort. Recent literature highlights different strategies to mitigate GHG emissions in the livestock sector. Animal welfare is a criterion of sustainability and any strategy designed to reduce the carbon footprint of livestock production should consider animal welfare amongst other sustainability metrics. We discuss and tabulate the likely relationships and trade-offs between the GHG mitigation potential of mitigation strategies and their welfare consequences, focusing on ruminant species and on cattle in particular. The major livestock GHG mitigation strategies were classified according to their mitigation approach as reducing total emissions (inhibiting methane production in the rumen), or reducing emissions intensity (Ei; reducing CH4 per output unit without directly targeting methanogenesis). Strategies classified as antimethanogenic included chemical inhibitors, electron acceptors (i.e. nitrates), ionophores (i.e. Monensin) and dietary lipids. Increasing diet digestibility, intensive housing, improving health and welfare, increasing reproductive efficiency and breeding for higher productivity were categorized as strategies that reduce Ei. Strategies that increase productivity are very promising ways to reduce the livestock carbon footprint, though in intensive systems this is likely to be achieved at the cost of welfare. Other strategies can effectively reduce GHG emissions whilst simultaneously improving animal welfare (e.g. feed supplementation or improving health). These win-win strategies should be strongly supported as they address both environmental and ethical sustainability. In order to identify the most cost-effective measures for improving environmental sustainability of livestock production, the consequences of current and future strategies for animal welfare must be scrutinized and contrasted against their effectiveness in mitigating climate change.

Multirate Flutter Suppression System Design for the Benchmark Active Controls Technology Wing. Part 2; Methodology Application Software Toolbox

NASA Technical Reports Server (NTRS)

Mason, Gregory S.; Berg, Martin C.; Mukhopadhyay, Vivek

2002-01-01

To study the effectiveness of various control system design methodologies, the NASA Langley Research Center initiated the Benchmark Active Controls Project. In this project, the various methodologies were applied to design a flutter suppression system for the Benchmark Active Controls Technology (BACT) Wing. This report describes the user's manual and software toolbox developed at the University of Washington to design a multirate flutter suppression control law for the BACT wing.

Ares I Scale Model Acoustic Test Above Deck Water Sound Suppression Results

NASA Technical Reports Server (NTRS)

Counter, Douglas D.; Houston, Janice D.

2011-01-01

The Ares I Scale Model Acoustic Test (ASMAT) program test matrix was designed to determine the acoustic reduction for the Liftoff acoustics (LOA) environment with an above deck water sound suppression system. The scale model test can be used to quantify the effectiveness of the water suppression system as well as optimize the systems necessary for the LOA noise reduction. Several water flow rates were tested to determine which rate provides the greatest acoustic reductions. Preliminary results are presented.

De-identifying a public use microdata file from the Canadian national discharge abstract database

PubMed Central

2011-01-01

Abstract Background The Canadian Institute for Health Information (CIHI) collects hospital discharge abstract data (DAD) from Canadian provinces and territories. There are many demands for the disclosure of this data for research and analysis to inform policy making. To expedite the disclosure of data for some of these purposes, the construction of a DAD public use microdata file (PUMF) was considered. Such purposes include: confirming some published results, providing broader feedback to CIHI to improve data quality, training students and fellows, providing an easily accessible data set for researchers to prepare for analyses on the full DAD data set, and serve as a large health data set for computer scientists and statisticians to evaluate analysis and data mining techniques. The objective of this study was to measure the probability of re-identification for records in a PUMF, and to de-identify a national DAD PUMF consisting of 10% of records. Methods Plausible attacks on a PUMF were evaluated. Based on these attacks, the 2008-2009 national DAD was de-identified. A new algorithm was developed to minimize the amount of suppression while maximizing the precision of the data. The acceptable threshold for the probability of correct re-identification of a record was set at between 0.04 and 0.05. Information loss was measured in terms of the extent of suppression and entropy. Results Two different PUMF files were produced, one with geographic information, and one with no geographic information but more clinical information. At a threshold of 0.05, the maximum proportion of records with the diagnosis code suppressed was 20%, but these suppressions represented only 8-9% of all values in the DAD. Our suppression algorithm has less information loss than a more traditional approach to suppression. Smaller regions, patients with longer stays, and age groups that are infrequently admitted to hospitals tend to be the ones with the highest rates of suppression. Conclusions The strategies we used to maximize data utility and minimize information loss can result in a PUMF that would be useful for the specific purposes noted earlier. However, to create a more detailed file with less information loss suitable for more complex health services research, the risk would need to be mitigated by requiring the data recipient to commit to a data sharing agreement. PMID:21861894

Developing, mechanizing and testing of a digital active flutter suppression system for a modified B-52 wind-tunnel model

NASA Technical Reports Server (NTRS)

Matthew, J. R.

1980-01-01

A digital flutter suppression system was developed and mechanized for a significantly modified version of the 1/30-scale B-52E aeroelastic wind tunnel model. A model configuration was identified that produced symmetric and antisymmetric flutter modes that occur at 2873N/sq m (60 psf) dynamic pressure with violent onset. The flutter suppression system, using one trailing edge control surface and the accelerometers on each wing, extended the flutter dynamic pressure of the model beyond the design limit of 4788N/sq m (100 psf). The hardware and software required to implement the flutter suppression system were designed and mechanized using digital computers in a fail-operate configuration. The model equipped with the system was tested in the Transonic Dynamics Tunnel at NASA Langley Research Center and results showed the flutter dynamic pressure of the model was extended beyond 4884N/sq m (102 psf).

Flutter suppression by active control and its benefits

NASA Technical Reports Server (NTRS)

Doggett, R. V., Jr.; Townsend, J. C.

1976-01-01

A general discussion of the airplane applications of active flutter suppression systems is presented with focus on supersonic cruise aircraft configurations. Topics addressed include a brief historical review; benefits, risks, and concerns; methods of application; and applicable configurations. Results are presented where the direct operating costs and performance benefits of an arrow wing supersonic cruise vehicle equipped with an active flutter suppression system are compared with corresponding costs and performance of the same baseline airplane where the flutter deficiency was corrected by passive methods (increases in structural stiffness). The design, synthesis, and conceptual mechanization of the active flutter suppression system are discussed. The results show that a substantial weight savings can be accomplished by using the active system. For the same payload and range, airplane direct operating costs are reduced by using the active system. The results also indicate that the weight savings translates into increased range or payload.

Failure Scenarios and Mitigations for the BABAR Superconducting Solenoid

NASA Astrophysics Data System (ADS)

Thompson, EunJoo; Candia, A.; Craddock, W. W.; Racine, M.; Weisend, J. G.

2006-04-01

The cryogenic department at the Stanford Linear Accelerator Center is responsible for the operation, troubleshooting, and upgrade of the 1.5 Tesla superconducting solenoid detector for the BABAR B-factory experiment. Events that disable the detector are rare but significantly impact the availability of the detector for physics research. As a result, a number of systems and procedures have been developed over time to minimize the downtime of the detector, for example improved control systems, improved and automatic backup systems, and spares for all major components. Together they can prevent or mitigate many of the failures experienced by the utilities, mechanical systems, controls and instrumentation. In this paper we describe various failure scenarios, their effect on the detector, and the modifications made to mitigate the effects of the failure. As a result of these modifications the reliability of the detector has increased significantly with only 3 shutdowns of the detector due to cryogenics systems over the last 2 years.

A New Control Method to Mitigate Power Fluctuations for Grid Integrated PV/Wind Hybrid Power System Using Ultracapacitors

NASA Astrophysics Data System (ADS)

Jayalakshmi, N. S.; Gaonkar, D. N.

2016-08-01

The output power obtained from solar-wind hybrid system fluctuates with changes in weather conditions. These power fluctuations cause adverse effects on the voltage, frequency and transient stability of the utility grid. In this paper, a control method is presented for power smoothing of grid integrated PV/wind hybrid system using ultracapacitors in a DC coupled structure. The power fluctuations of hybrid system are mitigated and smoothed power is supplied to the utility grid. In this work both photovoltaic (PV) panels and the wind generator are controlled to operate at their maximum power point. The grid side inverter control strategy presented in this paper maintains DC link voltage constant while injecting power to the grid at unity power factor considering different operating conditions. Actual solar irradiation and wind speed data are used in this study to evaluate the performance of the developed system using MATLAB/Simulink software. The simulation results show that output power fluctuations of solar-wind hybrid system can be significantly mitigated using the ultracapacitor based storage system.

The impact of shale gas on the cost and feasibility of meeting climate targets—A global energy system model analysis and an exploration of uncertainties

DOE PAGES

Few, Sheridan; Gambhir, Ajay; Napp, Tamaryn; ...

2017-01-27

There exists considerable uncertainty over both shale and conventional gas resource availability and extraction costs, as well as the fugitive methane emissions associated with shale gas extraction and its possible role in mitigating climate change. This study uses a multi-region energy system model, TIAM (TIMES integrated assessment model), to consider the impact of a range of conventional and shale gas cost and availability assessments on mitigation scenarios aimed at achieving a limit to global warming of below 2 °C in 2100, with a 50% likelihood. When adding shale gas to the global energy mix, the reduction to the global energymore » system cost is relatively small (up to 0.4%), and the mitigation cost increases by 1%–3% under all cost assumptions. The impact of a “dash for shale gas”, of unavailability of carbon capture and storage, of increased barriers to investment in low carbon technologies, and of higher than expected leakage rates, are also considered; and are each found to have the potential to increase the cost and reduce feasibility of meeting global temperature goals. Finally, we conclude that the extraction of shale gas is not likely to significantly reduce the effort required to mitigate climate change under globally coordinated action, but could increase required mitigation effort if not handled sufficiently carefully.« less

The impact of shale gas on the cost and feasibility of meeting climate targets—A global energy system model analysis and an exploration of uncertainties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Few, Sheridan; Gambhir, Ajay; Napp, Tamaryn

There exists considerable uncertainty over both shale and conventional gas resource availability and extraction costs, as well as the fugitive methane emissions associated with shale gas extraction and its possible role in mitigating climate change. This study uses a multi-region energy system model, TIAM (TIMES integrated assessment model), to consider the impact of a range of conventional and shale gas cost and availability assessments on mitigation scenarios aimed at achieving a limit to global warming of below 2 °C in 2100, with a 50% likelihood. When adding shale gas to the global energy mix, the reduction to the global energymore » system cost is relatively small (up to 0.4%), and the mitigation cost increases by 1%–3% under all cost assumptions. The impact of a “dash for shale gas”, of unavailability of carbon capture and storage, of increased barriers to investment in low carbon technologies, and of higher than expected leakage rates, are also considered; and are each found to have the potential to increase the cost and reduce feasibility of meeting global temperature goals. Finally, we conclude that the extraction of shale gas is not likely to significantly reduce the effort required to mitigate climate change under globally coordinated action, but could increase required mitigation effort if not handled sufficiently carefully.« less

Thoron Mitigation System based on charcoal bed for applications in thorium fuel cycle facilities (part 2): Development, characterization, and performance evaluation.

PubMed

Sudeep Kumara, K; Sahoo, B K; Gaware, J J; Sapra, B K; Mayya, Y S; Karunakara, N

2017-06-01

Exposure due to thoron ( 220 Rn) gas and its decay products in a thorium fuel cycle facility handling thorium or 232 U/ 233 U mixture compounds is an important issue of radiological concern requiring control and mitigation. Adsorption in a flow-through charcoal bed offers an excellent method of alleviating the release of 220 Rn into occupational and public domain. In this paper, we present the design, development, and characterization of a Thoron Mitigation System (TMS) for industrial application. Systematic experiments were conducted in the TMS for examining the 220 Rn mitigation characteristics with respect to a host of parameters such as flow rate, pressure drop, charcoal grain size, charcoal mass and bed depth, water content, and heat of the carrier gas. An analysis of the experimental data shows that 220 Rn attenuation in a flow through charcoal bed is not exponential with respect to the residence time, L/U a (L: bed depth; U a : superficial velocity), but follows a power law behaviour, which can be attributed to the occurrence of large voids due to wall channeling in a flow through bed. The study demonstrates the regeneration of charcoal adsorption capacity degraded due to moisture adsorption, by hot air blowing technique. It is found that the mitigation factor (MF), which is the ratio of the inlet 220 Rn concentration (C in ) to the outlet 220 Rn concentration (C out ), of more than 10 4 for the TMS is easily achievable during continuous operation (>1000 h) at a flow rate of 40 L min -1 with negligible (<1 cm of water column) pressure drop. The Thoron Mitigation System based on adsorption on charcoal bed offers a compact and effective device to remove 220 Rn from affluent air streams in a space constrained domain. The prototype system has been installed in a thorium fuel cycle facility where it is being evaluated for its long-term performance and overall effectiveness in mitigating 220 Rn levels in the workplace. Copyright © 2017 Elsevier Ltd. All rights reserved.

Implications of sustainable development considerations for comparability across NDCs

NASA Astrophysics Data System (ADS)

Iyer, G.; Edmonds, J.; Calvin, K. V.; Hartin, C.; McJeon, H. C.; Clarke, L.

2017-12-01

The Paris Agreement delegates the establishment of national climate goals to individual governments through the nationally determined contributions (NDCs). Because of the absence of a commonly agreed burden-sharing scheme within the Agreement, assessments of comparability of mitigation efforts were and will continue to be important aspects of international climate change negotiations, as domestic decision-makers are interested in knowing whether other countries undertake comparable levels of effort in reducing emissions. At the same time, there are well-recognized relationships between mitigation and other national priorities, including the Sustainable Development Goals (SDGs). This raises a question about how the linkages of such goals to mitigation might influence comparability assessments. This is an important issue, because countries are expected to include not only perceptions of comparability in the context of climate mitigation, but also relationships of mitigation with the broader SDGs. We use GCAM, a global integrated assessment model that tracks the interactions across economic, energy, agricultural and land-use systems for 32 geopolitical regions under one consistent framework to illustrate the relationships between the NDCs and a subset of the broader SDGs. We study the implications of considering these relationships for comparability assessments. The relationships between mitigation and the broader SDGs are rather complex because of the interconnected nature of human and Earth systems requiring the use of integrated tools such as GCAM that simultaneously track interactions across various human and Earth systems. Our analysis highlights that while some SDG measures are enhanced by the implementation of NDCs, others are degraded. In addition, the NDCs can have effects that extend beyond national boundaries to affect international SDGs and in some instances, also carry global impact. Finally, the distributions of effort across NDCs based on conventional metrics (such as emissions and cost) and the consequences of meeting the domestic mitigation component of the NDCs for a broader set of SDGs are not necessarily the same. Our study provides a foundation to conduct a broader assessment of the comparability across the NDCs using integrated human-Earth systems models.

Wake Turbulence Mitigation for Departures (WTMD) Prototype System - Software Design Document

NASA Technical Reports Server (NTRS)

Sturdy, James L.

2008-01-01

This document describes the software design of a prototype Wake Turbulence Mitigation for Departures (WTMD) system that was evaluated in shadow mode operation at the Saint Louis (KSTL) and Houston (KIAH) airports. This document describes the software that provides the system framework, communications, user displays, and hosts the Wind Forecasting Algorithm (WFA) software developed by the M.I.T. Lincoln Laboratory (MIT-LL). The WFA algorithms and software are described in a separate document produced by MIT-LL.

49 CFR 552.12 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Expedited Rulemaking To Establish Dynamic Automatic Suppression System Test Procedures for Federal Motor... subpart, the following definitions apply: (a) Dynamic automatic suppression system (DASS) means a portion of an air bag system that automatically controls whether or not the air bag deploys during a crash by...

30 CFR 57.4761 - Underground shops.

Code of Federal Regulations, 2011 CFR

2011-07-01

... an automatic fire suppression system in conjunction with an alternate escape route. The alternative... core, are acceptable provided that an automatic sprinkler or deluge system is installed that provides... conditions and procedures. (d) Automatic fire suppression system and escape route. If used as an alternative...

30 CFR 57.4761 - Underground shops.

Code of Federal Regulations, 2013 CFR

2013-07-01

... an automatic fire suppression system in conjunction with an alternate escape route. The alternative... core, are acceptable provided that an automatic sprinkler or deluge system is installed that provides... conditions and procedures. (d) Automatic fire suppression system and escape route. If used as an alternative...

30 CFR 57.4761 - Underground shops.

Code of Federal Regulations, 2014 CFR

2014-07-01

... an automatic fire suppression system in conjunction with an alternate escape route. The alternative... core, are acceptable provided that an automatic sprinkler or deluge system is installed that provides... conditions and procedures. (d) Automatic fire suppression system and escape route. If used as an alternative...

30 CFR 57.4761 - Underground shops.

Code of Federal Regulations, 2012 CFR

2012-07-01

... an automatic fire suppression system in conjunction with an alternate escape route. The alternative... core, are acceptable provided that an automatic sprinkler or deluge system is installed that provides... conditions and procedures. (d) Automatic fire suppression system and escape route. If used as an alternative...

Wiener filter preprocessing for OFDM systems in the presence of both nonstationary and stationary phase noises

NASA Astrophysics Data System (ADS)

Zhong, Ke; Lei, Xia; Li, Shaoqian

2013-12-01

Statistics-based intercarrier interference (ICI) mitigation algorithm is proposed for orthogonal frequency division multiplexing systems in presence of both nonstationary and stationary phase noises. By utilizing the statistics of phase noise, which can be obtained from measurements or data sheets, a Wiener filter preprocessing algorithm for ICI mitigation is proposed. The proposed algorithm can be regarded as a performance-improving technique for the previous researches on phase noise cancelation. Simulation results show that the proposed algorithm can effectively mitigate ICI and lower the error floor, and therefore significantly improve the performances of previous researches on phase noise cancelation, especially in the presence of severe phase noise.

New Developments in FPGA Devices: SEUs and Fail-Safe Strategies from the NASA Goddard Perspective

NASA Technical Reports Server (NTRS)

Berg, Melanie; LaBel, Kenneth; Pellish, Jonathan

2016-01-01

It has been shown that, when exposed to radiation environments, each Field Programmable Gate Array (FPGA) device has unique error signatures. Subsequently, fail-safe and mitigation strategies will differ per FPGA type. In this session several design approaches for safe systems will be presented. It will also explore the benefits and limitations of several mitigation techniques. The intention of the presentation is to provide information regarding FPGA types, their susceptibilities, and proven fail-safe strategies; so that users can select appropriate mitigation and perform the required trade for system insertion. The presentation will describe three types of FPGA devices and their susceptibilities in radiation environments.

Space Debris Mitigation Efforts through the Disposition of the Service Module of the Unmanned Space Experiment Recovery System (USERS)

NASA Astrophysics Data System (ADS)

Ijichi, Koichi; Ushikoshi, Atsuo; Nakamura, Shuji; Kanai, Hiroshi

The Unmanned Space Experiment Recovery System (USERS) Project has been completed with full success, and the Service Module (SEM) of the USERS Spacecraft, which supported the recovery portion of the spacecraft which was left on the orbit, was properly disposed to the maximum extent as possible according to the IADC debris mitigation guideline and re-entered the atmosphere on June 15, 2007 (JST). USERS spacecraft disposition by possible means available at the mission completion showed good example of realizing debris mitigation purpose in spite of originally different design baseline, and obtained actual data and experiences to be reflected for future space programs.

Mitigating GHG emissions in dairy production

USDA-ARS?s Scientific Manuscript database

Comprehensive inventories of greenhouse gas (GHG) mitigation options for animal agriculture have been published recently. For dairy production systems, management option include (1) manipulation of dietary components (e.g., forages, concentrates) and use of feed additives (e.g., oils, tannins) to re...

UPDATE ON RADON MITIGATION RESEARCH IN SCHOOLS

EPA Science Inventory

The paper is an overview of research by EPA's Air and Energy Engineering Research Laboratory (AEERL) on radon mitigation in 47 schools since 1988. he structural and heating, ventilating, and air-conditioning (HVAC) system characteristics of the research schools are presented, alo...

Noise suppressing capillary separation system

DOEpatents

Yeung, Edward S.; Xue, Yongjun

1996-07-30

A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.

Noise suppressing capillary separation system

DOEpatents

Yeung, E.S.; Xue, Y.

1996-07-30

A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans. 13 figs.

Mitigating environmental impacts through the energetic use of wood: Regional displacement factors generated by means of substituting non-wood heating systems.

PubMed

Wolf, Christian; Klein, Daniel; Richter, Klaus; Weber-Blaschke, Gabriele

2016-11-01

Wood biomass, especially when applied for heating, plays an important role for mitigating environmental impacts such as climate change and the transition towards higher shares of renewable energy in today's energy mix. However, the magnitude of mitigation benefits and burdens associated with wood use can vary greatly depending on regional parameters such as the displaced fossil reference or heating mix. Therefore, regionalized displacement factors, considering region-specific production conditions and substituted products are required when assessing the precise contribution of wood biomass towards the mitigation of environmental impacts. We carried out Life Cycle Assessments of wood heating systems for typical Bavarian conditions and substitute energy carriers with a focus on climate change and particulate matter emissions. In order to showcase regional effects, we created weighted displacement factors for the region of Bavaria, based on installed capacities of individual wood heating systems and the harvested tree species distribution. The study reveals that GHG displacements between -57gCO2-eq.∗MJ(-1) of useful energy through the substitution of natural gas with a 15kW spruce pellets heating system and -165gCO2-eq.∗MJ(-1) through the substitution of power utilized for heating with a modern 6kW beech split log heating system can be achieved. It was shown that the GHG mitigation potentials of wood utilization are overestimated through the common use of light fuel oil as the only reference system. We further propose a methodology for the calculation of displacement factors which is adaptable to other regions worldwide. Based on our approach it is possible to generate displacement factors for wood heating systems which enable accurate decision-making for project planning in households, heating plants, communities and also for entire regions. Copyright © 2016 Elsevier B.V. All rights reserved.

Adaptation and Mitigation in Agriculture: A Review of Synergies and Tradeoffs and How EO Could Improve Understanding and Outcomes

NASA Astrophysics Data System (ADS)

Barbieri, L.; Wollenberg, E.

2017-12-01

We present a review of the published literature on agricultural adaptation and mitigation, and report on the current evidence as to whether changes in agricultural practices meant to achieve mitigation or adaptation goals can be dual purpose: simultaneously reducing greenhouse gas (GHG) emissions and helping to facilitate adaptation. We characterize the spatio-temporal and system trends in how adaptation and mitigation outcomes are being achieved, and report on the current technical and knowledge gaps that exist and where Earth observations (EO) could improve our understanding. Agriculture contributes 12% GHG emissions globally, roughly one third from the developing world. Nearly 70% of the technical mitigation potential in agriculture sector occurs in these countries, however, while the mitigation potential is high, agricultural productivity also relies heavily on climate factors. With climate change, agricultural systems already, and will increasingly, need to adapt to extreme events and variability in temperatures and precipitation. This underscores the importance of implementing agricultural practices that can both reduce GHG emissions and help facilitate adaptation. Until recently, these objectives have been treated separately, but policy makers are increasingly calling for a joint approach to improve synergies, and avoid tradeoffs. There remain many complications in considering a joint approach: lack of clear conceptual frameworks, knowledge gaps in scientific understanding and evidence associated with adaptation and mitigation outcomes, and the abilities and motivations of stakeholders to consider both objectives. We review 56 peer-reviewed publications and present results from an in-depth analysis to answer two major concerns: to what extent is evidence provided for claims of synergistic outcomes, and what uncertainty surrounds this evidence. Our results show that only 21% of studies empirically measured both mitigation and adaptation outcomes, and claims of synergies are not well substantiated, and evidence is provided at questionable spatio-temporal scales. We highlight information that could be provided by coordinated, comprehensive and sustained EO which could benefit this critical goal of simultaneously achieving agricultural adaptation and mitigation.

Co-benefits, trade-offs, barriers and policies for greenhouse gas mitigation in the agriculture, forestry and other land use (AFOLU) sector.

PubMed

Bustamante, Mercedes; Robledo-Abad, Carmenza; Harper, Richard; Mbow, Cheikh; Ravindranat, Nijavalli H; Sperling, Frank; Haberl, Helmut; Pinto, Alexandre de Siqueira; Smith, Pete

2014-10-01

The agriculture, forestry and other land use (AFOLU) sector is responsible for approximately 25% of anthropogenic GHG emissions mainly from deforestation and agricultural emissions from livestock, soil and nutrient management. Mitigation from the sector is thus extremely important in meeting emission reduction targets. The sector offers a variety of cost-competitive mitigation options with most analyses indicating a decline in emissions largely due to decreasing deforestation rates. Sustainability criteria are needed to guide development and implementation of AFOLU mitigation measures with particular focus on multifunctional systems that allow the delivery of multiple services from land. It is striking that almost all of the positive and negative impacts, opportunities and barriers are context specific, precluding generic statements about which AFOLU mitigation measures have the greatest promise at a global scale. This finding underlines the importance of considering each mitigation strategy on a case-by-case basis, systemic effects when implementing mitigation options on the national scale, and suggests that policies need to be flexible enough to allow such assessments. National and international agricultural and forest (climate) policies have the potential to alter the opportunity costs of specific land uses in ways that increase opportunities or barriers for attaining climate change mitigation goals. Policies governing practices in agriculture and in forest conservation and management need to account for both effective mitigation and adaptation and can help to orient practices in agriculture and in forestry towards global sharing of innovative technologies for the efficient use of land resources. Different policy instruments, especially economic incentives and regulatory approaches, are currently being applied however, for its successful implementation it is critical to understand how land-use decisions are made and how new social, political and economic forces in the future will influence this process. © 2014 John Wiley & Sons Ltd.

Overview of the NASA Systems Approach to Crashworthiness Program

NASA Technical Reports Server (NTRS)

Jones, Lisa E.

2002-01-01

The NASA Aviation Safety Program was developed in response to the federal government's goal to reduce the fatal accident rate for aviation by 80% within 10 years. Accident Mitigation is a primary element of the Aviation Safety Program. The overall Accident Mitigation goal is to provide technology to the air transport industry to enable a decrease in the rate of fatalities and injury from crash loads and from in-flight and post-crash explosion and/or fire. Accident Mitigation is divided into two main elements - Fire Prevention and Systems Approach to Crashworthiness. The Systems Approach to Crashworthiness goal is to develop and promote technology that will increase the human survival rate or reduce the fatality rate in survivable accidents. The technical background and planning, selected technical activities, and summary of future efforts will be presented in this paper.

Effects of seeding rate and poultry litter on weed suppression from a rolled cereal rye cover crop

USDA-ARS?s Scientific Manuscript database

Growing enough cover crop biomass to adequately suppress weeds is one of the primary challenges in reduced-tillage systems that rely on mulch-based weed suppression. We investigated two approaches to increasing cereal rye biomass for improved weed suppression: (1) increasing soil fertility and (2) i...

Optimising import risk mitigation: anticipating the unintended consequences and competing risks of informal trade.

PubMed

Hueston, W; Travis, D; van Klink, E

2011-04-01

The effectiveness of risk mitigation may be compromised by informal trade, including illegal activities, parallel markets and extra-legal activities. While no regulatory system is 100% effective in eliminating the risk of disease transmission through animal and animal product trade, extreme risk aversion in formal import health regulations may increase informal trade, with the unintended consequence of creating additional risks outside regulatory purview. Optimal risk mitigation on a national scale requires scientifically sound yet flexible mitigation strategies that can address the competing risks of formal and informal trade. More robust risk analysis and creative engagement of nontraditional partners provide avenues for addressing informal trade.

Development and Application of a Clinical Microsystem Simulation Methodology for Human Factors-Based Research of Alarm Fatigue.

PubMed

Kobayashi, Leo; Gosbee, John W; Merck, Derek L

2017-07-01

(1) To develop a clinical microsystem simulation methodology for alarm fatigue research with a human factors engineering (HFE) assessment framework and (2) to explore its application to the comparative examination of different approaches to patient monitoring and provider notification. Problems with the design, implementation, and real-world use of patient monitoring systems result in alarm fatigue. A multidisciplinary team is developing an open-source tool kit to promote bedside informatics research and mitigate alarm fatigue. Simulation, HFE, and computer science experts created a novel simulation methodology to study alarm fatigue. Featuring multiple interconnected simulated patient scenarios with scripted timeline, "distractor" patient care tasks, and triggered true and false alarms, the methodology incorporated objective metrics to assess provider and system performance. Developed materials were implemented during institutional review board-approved study sessions that assessed and compared an experimental multiparametric alerting system with a standard monitor telemetry system for subject response, use characteristics, and end-user feedback. A four-patient simulation setup featuring objective metrics for participant task-related performance and response to alarms was developed along with accompanying structured HFE assessment (questionnaire and interview) for monitor systems use testing. Two pilot and four study sessions with individual nurse subjects elicited true alarm and false alarm responses (including diversion from assigned tasks) as well as nonresponses to true alarms. In-simulation observation and subject questionnaires were used to test the experimental system's approach to suppressing false alarms and alerting providers. A novel investigative methodology applied simulation and HFE techniques to replicate and study alarm fatigue in controlled settings for systems assessment and experimental research purposes.

Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents.

PubMed

Mailloux, Ryan J; Adjeitey, Cyril Nii-Klu; Harper, Mary-Ellen

2010-10-13

Uncoupling protein-2 (UCP2) is known to suppress mitochondrial reactive oxygen species (ROS) production and is employed by drug-resistant cancer cells to mitigate oxidative stress. Using the drug-sensitive HL-60 cells and the drug-resistant MX2 subline as model systems, we show that genipin, a UCP2 inhibitor, sensitizes drug-resistant cells to cytotoxic agents. Increased MX2 cell death was observed upon co-treatment with genipin and different doses of menadione, doxorubicin, and epirubicin. DCFH-DA fluorimetry revealed that the increase in MX2 cell death was accompanied by enhanced cellular ROS levels. The drug-induced increase in ROS was linked to genipin-mediated inhibition of mitochondrial proton leak. State 4 and resting cellular respiratory rates were higher in the MX2 cells in comparison to the HL-60 cells, and the increased respiration was readily suppressed by genipin in the MX2 cells. UCP2 accounted for a remarkable 37% of the resting cellular oxygen consumption indicating that the MX2 cells are functionally reliant on this protein. Higher amounts of UCP2 protein were detected in the MX2 versus the HL-60 mitochondria. The observed effects of genipin were absent in the HL-60 cells pointing to the selectivity of this natural product for drug-resistant cells. The specificity of genipin for UCP2 was confirmed using CHO cells stably expressing UCP2 in which genipin induced an ∼22% decrease in state 4 respiration. These effects were absent in empty vector CHO cells expressing no UCP2. Thus, the chemical inhibition of UCP2 with genipin sensitizes multidrug-resistant cancer cells to cytotoxic agents.

A Decision Support System for Mitigating Stream Temperature Impacts in the Sacramento River

NASA Astrophysics Data System (ADS)

Caldwell, R. J.; Zagona, E. A.; Rajagopalan, B.

2014-12-01

Increasing demands on the limited and variable water supply across the West can result in insufficient streamflow to sustain healthy fish habitat. We develop an integrated decision support system (DSS) for modeling and mitigating stream temperature impacts and demonstrate it on the Sacramento River system in California. Water management in the Sacramento River is a complex task with a diverse set of demands ranging from municipal supply to mitigation of fisheries impacts due to high water temperatures. Current operations utilize the temperature control device (TCD) structure at Shasta Dam to mitigate these high water temperatures downstream at designated compliance points. The TCD structure at Shasta Dam offers a rather unique opportunity to mitigate water temperature violations through adjustments to both release volume and temperature. In this study, we develop and evaluate a model-based DSS with four broad components that are coupled to produce the decision tool for stream temperature mitigation: (i) a suite of statistical models for modeling stream temperature attributes using hydrology and climate variables of critical importance to fish habitat; (ii) a reservoir thermal model for modeling the thermal structure and, consequently, the water release temperature, (iii) a stochastic weather generator to simulate weather sequences consistent with seasonal outlooks; and, (iv) a set of decision rules (i.e., 'rubric') for reservoir water releases in response to outputs from the above components. Multiple options for modifying releases at Shasta Dam were considered in the DSS, including mixing water from multiple elevations through the TCD and using different acceptable levels of risk. The DSS also incorporates forecast uncertainties and reservoir operating options to help mitigate stream temperature impacts for fish habitat, while efficiently using the reservoir water supply and cold pool storage. The use of these coupled tools in simulating impacts of future climate on stream temperature variability is also demonstrated. Results indicate that the DSS could substantially reduce the number of violations of thermal criteria, while ensuring maintenance of the cold pool storage throughout the summer.

Applying a systems approach to assess carbon emission reductions from climate change mitigation in Mexico’s forest sector

NASA Astrophysics Data System (ADS)

Olguin, Marcela; Wayson, Craig; Fellows, Max; Birdsey, Richard; Smyth, Carolyn E.; Magnan, Michael; Dugan, Alexa J.; Mascorro, Vanessa S.; Alanís, Armando; Serrano, Enrique; Kurz, Werner A.

2018-03-01

The Paris Agreement of the United Nation Framework Convention on Climate Change calls for a balance of anthropogenic greenhouse emissions and removals in the latter part of this century. Mexico indicated in its Intended Nationally Determined Contribution and its Climate Change Mid-Century Strategy that the land sector will contribute to meeting GHG emission reduction goals. Since 2012, the Mexican government through its National Forestry Commission, with international financial and technical support, has been developing carbon dynamics models to explore climate change mitigation options in the forest sector. Following a systems approach, here we assess the biophysical mitigation potential of forest ecosystems, harvested wood products and their substitution benefits (i.e. the change in emissions resulting from substitution of wood for more emissions-intensive products and fossil fuels), for policy alternatives considered by the Mexican government, such as a net zero deforestation rate and sustainable forest management. We used available analytical frameworks (Carbon Budget Model of the Canadian Forest Sector and a harvested wood products model), parameterized with local input data in two contrasting Mexican states. Using information from the National Forest Monitoring System (e.g. forest inventories, remote sensing, disturbance data), we demonstrate that activities aimed at reaching a net-zero deforestation rate can yield significant CO2e mitigation benefits by 2030 and 2050 relative to a baseline scenario (‘business as usual’), but if combined with increasing forest harvest to produce long-lived products and substitute more energy-intensive materials, emissions reductions could also provide other co-benefits (e.g. jobs, illegal logging reduction). We concluded that the relative impact of mitigation activities is locally dependent, suggesting that mitigation strategies should be designed and implemented at sub-national scales. We were also encouraged about the ability of the modeling framework to effectively use Mexico’s data, and showed the need to include multiple sectors and types of collaborators (scientific and policy-maker communities) to design more comprehensive portfolios for climate change mitigation.

Technology Maturity for the Habitable-zone Exoplanet Imaging Mission (HabEx) Concept

NASA Astrophysics Data System (ADS)

Morgan, Rhonda; Warfield, Keith R.; Stahl, H. Philip; Mennesson, Bertrand; Nikzad, Shouleh; nissen, joel; Balasubramanian, Kunjithapatham; Krist, John; Mawet, Dimitri; Stapelfeldt, Karl; warwick, Steve

2018-01-01

HabEx Architecture A is a 4m unobscured telescope optimized for direct imaging and spectroscopy of potentially habitable exoplanets, and also enables a wide range of general astrophysics science. The exoplanet detection and characterization drives the enabling core technologies. A hybrid starlight suppression approach of a starshade and coronagraph diversifies technology maturation risk. In this poster we assess these exoplanet-driven technologies, including elements of coronagraphs, starshades, mirrors, jitter mitigation, wavefront control, and detectors. By utilizing high technology readiness solutions where feasible, and identifying required technology development that can begin early, HabEx will be well positioned for assessment by the community in 2020 Astrophysics Decadal Survey.

Practical implementation of spectral-intensity dispersion-canceled optical coherence tomography with artifact suppression

NASA Astrophysics Data System (ADS)

Shirai, Tomohiro; Friberg, Ari T.

2018-04-01

Dispersion-canceled optical coherence tomography (OCT) based on spectral intensity interferometry was devised as a classical counterpart of quantum OCT to enhance the basic performance of conventional OCT. In this paper, we demonstrate experimentally that an alternative method of realizing this kind of OCT by means of two optical fiber couplers and a single spectrometer is a more practical and reliable option than the existing methods proposed previously. Furthermore, we develop a recipe for reducing multiple artifacts simultaneously on the basis of simple averaging and verify experimentally that it works successfully in the sense that all the artifacts are mitigated effectively and only the true signals carrying structural information about the sample survive.

Improving Our Odds: Success through Continuous Risk Management

NASA Technical Reports Server (NTRS)

Greenhalgh, Phillip O.

2009-01-01

Launching a rocket, running a business, driving to work and even day-to-day living all involve some degree of risk. Risk is ever present yet not always recognized, adequately assessed and appropriately mitigated. Identification, assessment and mitigation of risk are elements of the risk management component of the "continuous improvement" way of life that has become a hallmark of successful and progressive enterprises. While the application of risk management techniques to provide continuous improvement may be detailed and extensive, the philosophy, ideals and tools can be beneficially applied to all situations. Experiences with the use of risk identification, assessment and mitigation techniques for complex systems and processes are described. System safety efforts and tools used to examine potential risks of the Ares I First Stage of NASA s new Constellation Crew Launch Vehicle (CLV) presently being designed are noted as examples. Recommendations from lessons learned are provided for the application of risk management during the development of new systems as well as for the improvement of existing systems. Lessons learned and suggestions given are also examined for applicability to simple systems, uncomplicated processes and routine personal daily tasks. This paper informs the reader of varied uses of risk management efforts and techniques to identify, assess and mitigate risk for improvement of products, success of business, protection of people and enhancement of personal life.

Supplemental Environmental Assessment & Finding of No Significant Impact: Louisville Bend State Wildlife Area Fish and Wildlife Habitat Rehabilitation

DTIC Science & Technology

2013-05-01

and Maintenance of the Missouri River Bank Stabilization and Navigation Project, and Operation of the Kansas River Reservoir System, and acquiring and...developing lands to produce habitat as directed by the BSNP Mitigation Project. The proposed project would be constructed under the authority of...the Mitigation Project. The Missouri River BSNP Mitigation Project of Missouri, Kansas , Iowa, and Nebraska was authorized by Section 601 (a) of the

Cities’ Role in Mitigating United States Food System Greenhouse Gas Emissions

PubMed Central

2018-01-01

Current trends of urbanization, population growth, and economic development have made cities a focal point for mitigating global greenhouse gas (GHG) emissions. The substantial contribution of food consumption to climate change necessitates urban action to reduce the carbon intensity of the food system. While food system GHG mitigation strategies often focus on production, we argue that urban influence dominates this sector’s emissions and that consumers in cities must be the primary drivers of mitigation. We quantify life cycle GHG emissions of the United States food system through data collected from literature and government sources producing an estimated total of 3800 kg CO2e/capita in 2010, with cities directly influencing approximately two-thirds of food sector GHG emissions. We then assess the potential for cities to reduce emissions through selected measures; examples include up-scaling urban agriculture and home delivery of grocery options, which each may achieve emissions reductions on the order of 0.4 and ∼1% of this total, respectively. Meanwhile, changes in waste management practices and reduction of postdistribution food waste by 50% reduce total food sector emissions by 5 and 11%, respectively. Consideration of the scale of benefits achievable through policy goals can enable cities to formulate strategies that will assist in achieving deep long-term GHG emissions targets. PMID:29717606

Cities' Role in Mitigating United States Food System Greenhouse Gas Emissions.

PubMed

Mohareb, Eugene A; Heller, Martin C; Guthrie, Peter M

2018-05-15

Current trends of urbanization, population growth, and economic development have made cities a focal point for mitigating global greenhouse gas (GHG) emissions. The substantial contribution of food consumption to climate change necessitates urban action to reduce the carbon intensity of the food system. While food system GHG mitigation strategies often focus on production, we argue that urban influence dominates this sector's emissions and that consumers in cities must be the primary drivers of mitigation. We quantify life cycle GHG emissions of the United States food system through data collected from literature and government sources producing an estimated total of 3800 kg CO 2 e/capita in 2010, with cities directly influencing approximately two-thirds of food sector GHG emissions. We then assess the potential for cities to reduce emissions through selected measures; examples include up-scaling urban agriculture and home delivery of grocery options, which each may achieve emissions reductions on the order of 0.4 and ∼1% of this total, respectively. Meanwhile, changes in waste management practices and reduction of postdistribution food waste by 50% reduce total food sector emissions by 5 and 11%, respectively. Consideration of the scale of benefits achievable through policy goals can enable cities to formulate strategies that will assist in achieving deep long-term GHG emissions targets.

Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway.

PubMed

Ali, Farrah; Khan, Bilal Azhar; Sultana, Sarwat

2016-09-05

UVB (Ultra-violet B) radiation is one of the major etiological factors in various dermal pathology viz. dermatitis, actinic folliculitis, solar urticaria, psoriasis and cancer among many others. UVB causes toxic manifestation in tissues by inciting inflammatory and tumor promoting events. We have designed this study to assess the anti-inflammatory and anti-tumor promotion effect of Wedelolactone (WDL) a specific IKK inhibitor. Results indicate significant restoration of anti-oxidative enzymes due to WDL treatments. We also found that WDL was effective in mitigating inflammatory markers consisting of MPO (myeloperoxidase), Mast cells trafficking, Langerhans cells suppression and COX 2 expression up regulation due to UVB exposure. We also deduce that WDL presented a promising intervention in attenuating early tumor promotion events caused by UVB exposure as indicated by the results of ODC (Ornithine Decarboxylase), Thymidine assay, Vimentin and VEGF (Vascular-endothelial growth factor) expression. This study was able to provide substantial cues for the therapeutic ability of Wedelolactone against inflammatory and tumor promoting events in murine skin depicting plausible role of NFkB pathway. Copyright © 2016 Elsevier B.V. All rights reserved.

Novel strategy to mitigate cathode catalyst degradation during air/air startup cycling via the atmospheric resistive switching mechanism of a hydrogen anode with a platinum catalyst supported on tantalum-doped titanium dioxide

NASA Astrophysics Data System (ADS)

Shintani, Haruhiko; Kojima, Yuya; Kakinuma, Katsuyoshi; Watanabe, Masahiro; Uchida, Makoto

2015-10-01

We propose a new strategy for alleviating the reverse current phenomenon using a unique ;atmospheric resistive switching mechanism; (ARSM) of a metal oxide semiconductor support, such that the electrical resistivity changes depending on the gas atmosphere. The membrane-electrode assembly (MEA) using Ta-doped TiO2-supported platinum (Pt/Ta-TiO2) as the anode catalyst showed approximately one order of magnitude greater resistance in air than in hydrogen. The overpotential of the hydrogen oxidation reaction was negligible up to at least 1.5 A cm-2. The losses of electrochemically active surface area and carbon corrosion of the cathode catalyst during air/air startup cycling were significantly suppressed by the use of the Pt/Ta-TiO2 anode. The decrease in the degradation is attributed to a reduction of the reverse current due to a low oxygen reduction reaction rate at the anode, which showed high resistivity in air. These results demonstrate the effectiveness of the ARSM in mitigating cathode catalyst degradation during air/air startup cycling.

Glacier Going to the Sun Road Rehabilitation Mitigation Shuttle Bus Evaluation.

DOT National Transportation Integrated Search

2008-03-31

As a mitigation measure during reconstruction of the Going to the Sun Road, Glacier National Park operated a shuttle bus system along three routes during the 2007 season. This report presents a multi-dimensional evaluation of the transportation servi...

Disaster mitigation action plan: Digital media on improving accountability and community relationships

NASA Astrophysics Data System (ADS)

Adila, I.; Dewi, W. W. A.; Tamitiadini, D.; Syauki, W. R.

2017-06-01

This study wants to address on how communication science is applied to Disaster Mitigation Plan. Especially, the implementation of Community Media and Development of Communication Technology that synergize to create a Disaster Mitigation Medium, which is appropriate for typology of Indonesia. Various levels of priorities that include disaster mitigation information, namely, increasing chain system of early warning systems, building evacuation, improving alertness and capacity to face a disaster, as well as minimizing disaster risk factor. Through this concept, mitigation actions plan of Tulungagung Coastal areas is expected to be applied in other regions in Indonesia by BNPB (Badan Nasional Penanggulangan Bencana). Having this strategy to be implemented based on region characteristics, it is expected that risk reduction process can be run optimally. As a result, the strategy is known as Community-Based Disaster Risk Reduction (PRBBK), which means as the organized-efforts by society for pra-, during, and post- disaster by using available resources as much as possible to prevent, reduce, avoid, and recover from the impact of disasters. Therefore, this result can be a Pilot Project for BNBP Indonesia, as a government decisive attitude for the next steps in protecting people residing in the region prone to natural disasters all over Indonesia.

Allotype suppression in an adoptive transfer system in adult mice: the specificity and feedback effects of a monoclonal IgG3 anti-(Igh-1b) allotype antibody.

PubMed Central

Curling, E M; Dresser, D W

1984-01-01

Using an adoptive transfer system in mice, an allotype-specific suppression has been induced by a monoclonal IgG3 anti-Igh-1b (Hyb 5.7) reagent. Suppression was specific for IgG2a (Igh-1b) and led to a compensatory increase of the Igh-1a response in irradiated mice reconstituted with allotype heterozygous (Igha/b) spleen cells. Suppression, which was not antigen-specific, lasted for at least 1 month after anti-allotype treatment. PMID:6365744