Hybrid energy storage systems utilizing redox active organic compounds
Wang, Wei; Xu, Wu; Li, Liyu; Yang, Zhenguo
2015-09-08
Redox flow batteries (RFB) have attracted considerable interest due to their ability to store large amounts of power and energy. Non-aqueous energy storage systems that utilize at least some aspects of RFB systems are attractive because they can offer an expansion of the operating potential window, which can improve on the system energy and power densities. One example of such systems has a separator separating first and second electrodes. The first electrode includes a first current collector and volume containing a first active material. The second electrode includes a second current collector and volume containing a second active material. During operation, the first source provides a flow of first active material to the first volume. The first active material includes a redox active organic compound dissolved in a non-aqueous, liquid electrolyte and the second active material includes a redox active metal.
40 CFR 60.2170 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2013 CFR
2013-07-01
... monitoring system quality assurance or quality control activities (including, as applicable, calibration... required monitoring system quality assurance or quality control activities including, as applicable... required monitoring system quality assurance or control activities in calculations used to report emissions...
Activated Sludge. Student Manual. Biological Treatment Process Control.
ERIC Educational Resources Information Center
Boe, Owen K.; Klopping, Paul H.
This student manual contains the textual material for a seven-lesson unit on activated sludge. Topic areas addressed in the lessons include: (1) activated sludge concepts and components (including aeration tanks, aeration systems, clarifiers, and sludge pumping systems); (2) activated sludge variations and modes; (3) biological nature of activated…
Mars transit vehicle thermal protection system: Issues, options, and trades
NASA Technical Reports Server (NTRS)
Brown, Norman
1986-01-01
A Mars mission is characterized by different mission phases. The thermal control of cryogenic propellant in a propulsive vehicle must withstand the different mission environments. Long term cryogenic storage may be achieved by passive or active systems. Passive cryo boiloff management features will include multilayer insulation, vapor cooled shield, and low conductance structural supports and penetrations. Active boiloff management incorporates the use of a refrigeration system. Key system trade areas include active verses passive system boiloff management (with respect to safety, reliability, and cost) and propellant tank insulation optimizations. Technology requirements include refrigeration technology advancements, insulation performance during long exposure, and cryogenic fluid transfer system for mission vehicle propellant tanking during vehicle buildip in LEO.
40 CFR 60.2735 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2014 CFR
2014-07-01
... activities including, as applicable, calibration checks and required zero and span adjustments. A monitoring... monitoring system quality assurance or control activities in calculations used to report emissions or...-control periods, and required monitoring system quality assurance or quality control activities including...
40 CFR 60.2735 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2013 CFR
2013-07-01
... activities including, as applicable, calibration checks and required zero and span adjustments. A monitoring... monitoring system quality assurance or control activities in calculations used to report emissions or...-control periods, and required monitoring system quality assurance or quality control activities including...
40 CFR 63.11890 - What are my additional general requirements for complying with this subpart?
Code of Federal Regulations, 2012 CFR
2012-07-01
... malfunctions and required monitoring system quality assurance or quality control activities (including, as... malfunctions, or required monitoring system quality assurance or control activities in calculations used to... source, including associated air pollution control components and monitoring system components, in a...
DOE and AID stand-alone photovoltaic activities
NASA Technical Reports Server (NTRS)
Bifano, W. J.; Ratajczak, A. F.
1983-01-01
The NASA Lewis Research Center (LeRC) is managing stand-alone photovoltaic (PV) system activities sponsored by the U.S. Department of Energy (DOE) and the U.S. Agency for International Development (AID). The DOE project includes village PV power demonstration projects in Gabon (four sites) and the Marshall Islands, PV-powered medical refrigerators in six countries, PV system microprocessor control development activities and PV-hybrid system assessments. The AID project includes a large village system in Tunisia, a water pumping/grain grinding project in Upper Volta, five medical clinics in four countries, PV-powered remote earth station application. These PV activities and summarizes significant findings to data are reviewed.
Integrated exhaust and electrically heated particulate filter regeneration systems
Gonze, Eugene V.; Paratore, Jr., Michael J.
2013-01-08
A system includes a particulate matter (PM) filter that includes multiple zones. An electrical heater includes heater segments that are associated with respective ones of the zones. The electrical heater is arranged upstream from and proximate with the PM filter. A post-fuel injection system injects fuel into at least one of a cylinder of an engine and an exhaust system. A control module is configured to operate in a first mode that includes activating the electrical heater to heat exhaust of the engine. The control module is also configured to operate in a second mode that includes activating the post-injection system to heat the exhaust. The control module selectively operates in at least one of the first mode and the second mode.
Guide for preparing active solar heating systems operation and maintenance manuals
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1991-01-01
This book presents a systematic and standardized approach to the preparation of operation and maintenance manuals for active solar heating systems. Provides an industry consensus of the best operating and maintenance procedures for large commercial-scale solar service water and space heating systems. A sample O M manual is included. 3-ring binder included.
Drones for aerodynamic and structural testing /DAST/ - A status report
NASA Technical Reports Server (NTRS)
Murrow, H. N.; Eckstrom, C. V.
1978-01-01
A program for providing research data on aerodynamic loads and active control systems on wings with supercritical airfoils in the transonic speed range is described. Analytical development, wind tunnel tests, and flight tests are included. A Firebee II target drone vehicle has been modified for use as a flight test facility. The program currently includes flight experiments on two aeroelastic research wings. The primary purpose of the first flight experiment is to demonstrate an active control system for flutter suppression on a transport-type wing. Design and fabrication of the wing are complete and after installing research instrumentation and the flutter suppression system, flight testing is expected to begin in early 1979. The experiment on the second research wing - a fuel-conservative transport type - is to demonstrate multiple active control systems including flutter suppression, maneuver load alleviation, gust load alleviation, and reduce static stability. Of special importance for this second experiment is the development and validation of integrated design methods which include the benefits of active controls in the structural design.
Nervous system active pharmaceutical ingredients (APIs), including anti-depressants and opioids, are important clinically administered pharmaceuticals within healthcare facilities. Concentrations and mass loadings of ten nervous system APIs and three nervous system API metaboli...
Simulation-Based Mission Rehearsal as a Human Activity System.
1996-09-01
explain this demonstrated importance of the people involved in MR, a human activity system model of simulation-based rehearsal was developed. It provides...Implications of this human activity system view are discussed, including: places in the mission preparation process where simulation can benefit operations
Liquid and Gaseous Waste Operations Department annual operating report CY 1996
DOE Office of Scientific and Technical Information (OSTI.GOV)
Maddox, J.J.; Scott, C.B.
1997-03-01
This annual report summarizes operating activities dealing with the process waste system, the liquid low-level waste system, and the gaseous waste system. It also describes upgrade activities dealing with the process and liquid low-level waste systems, the cathodic protection system, a stack ventilation system, and configuration control. Maintenance activities are described dealing with nonradiological wastewater treatment plant, process waste treatment plant and collection system, liquid low-level waste system, and gaseous waste system. Miscellaneous activities include training, audits/reviews/tours, and environmental restoration support.
40 CFR 60.2170 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2014 CFR
2014-07-01
... monitoring system quality assurance or quality control activities (including, as applicable, calibration... required monitoring system quality assurance or quality control activities including, as applicable... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Is there a minimum amount of monitoring...
Technology Systems. Laboratory Activities.
ERIC Educational Resources Information Center
Brame, Ray; And Others
This guide contains 43 modules of laboratory activities for technology education courses. Each module includes an instructor's resource sheet and the student laboratory activity. Instructor's resource sheets include some or all of the following elements: module number, course title, activity topic, estimated time, essential elements, objectives,…
NASA Technical Reports Server (NTRS)
Hanks, G. W.; Shomber, H. A.; Dethman, H. A.; Gratzer, L. B.; Maeshiro, A.; Gangsaas, D.; Blight, J. D.; Buchan, S. M.; Crumb, C. B.; Dorwart, R. J.
1981-01-01
The current status of the Active Controls Technology (ACT) for the advanced subsonic transport project is investigated through analysis of the systems technical data. Control systems technologies under examination include computerized reliability analysis, pitch axis fly by wire actuator, flaperon actuation system design trade study, control law synthesis and analysis, flutter mode control and gust load alleviation analysis, and implementation of alternative ACT systems. Extensive analysis of the computer techniques involved in each system is included.
The evolution of the protein synthesis system. I - A model of a primitive protein synthesis system
NASA Technical Reports Server (NTRS)
Mizutani, H.; Ponnamperuma, C.
1977-01-01
A model is developed to describe the evolution of the protein synthesis system. The model is comprised of two independent autocatalytic systems, one including one gene (A-gene) and two activated amino acid polymerases (O and A-polymerases), and the other including the addition of another gene (N-gene) and a nucleotide polymerase. Simulation results have suggested that even a small enzymic activity and polymerase specificity could lead the system to the most accurate protein synthesis, as far as permitted by transitions to systems with higher accuracy.
Young, K.K.; Wilkes, R.J.
1995-11-21
A transponder of an active digital sonar system identifies a multifrequency underwater activating sonar signal received from a remote sonar transmitter. The transponder includes a transducer that receives acoustic waves, including the activating sonar signal, and generates an analog electrical receipt signal. The analog electrical receipt signal is converted to a digital receipt signal and cross-correlated with a digital transmission signal pattern corresponding to the activating sonar signal. A relative peak in the cross-correlation value is indicative of the activating sonar signal having been received by the transponder. In response to identifying the activating sonar signal, the transponder transmits a responding multifrequency sonar signal. 4 figs.
Young, Kenneth K.; Wilkes, R. Jeffrey
1995-01-01
A transponder of an active digital sonar system identifies a multifrequency underwater activating sonar signal received from a remote sonar transmitter. The transponder includes a transducer that receives acoustic waves, including the activating sonar signal, and generates an analog electrical receipt signal. The analog electrical receipt signal is converted to a digital receipt signal and cross-correlated with a digital transmission signal pattern corresponding to the activating sonar signal. A relative peak in the cross-correlation value is indicative of the activating sonar signal having been received by the transponder. In response to identifying the activating sonar signal, the transponder transmits a responding multifrequency sonar signal.
Operations-oriented performance measures for freeway management systems : final report.
DOT National Transportation Integrated Search
2008-12-01
This report describes the second and final year activities of the project titled Using Operations-Oriented Performance Measures to Support Freeway Management Systems. Work activities included developing a prototype system architecture for testi...
Ultrasensitive surveillance of sensors and processes
Wegerich, Stephan W.; Jarman, Kristin K.; Gross, Kenneth C.
2001-01-01
A method and apparatus for monitoring a source of data for determining an operating state of a working system. The method includes determining a sensor (or source of data) arrangement associated with monitoring the source of data for a system, activating a method for performing a sequential probability ratio test if the data source includes a single data (sensor) source, activating a second method for performing a regression sequential possibility ratio testing procedure if the arrangement includes a pair of sensors (data sources) with signals which are linearly or non-linearly related; activating a third method for performing a bounded angle ratio test procedure if the sensor arrangement includes multiple sensors and utilizing at least one of the first, second and third methods to accumulate sensor signals and determining the operating state of the system.
Ultrasensitive surveillance of sensors and processes
Wegerich, Stephan W.; Jarman, Kristin K.; Gross, Kenneth C.
1999-01-01
A method and apparatus for monitoring a source of data for determining an operating state of a working system. The method includes determining a sensor (or source of data) arrangement associated with monitoring the source of data for a system, activating a method for performing a sequential probability ratio test if the data source includes a single data (sensor) source, activating a second method for performing a regression sequential possibility ratio testing procedure if the arrangement includes a pair of sensors (data sources) with signals which are linearly or non-linearly related; activating a third method for performing a bounded angle ratio test procedure if the sensor arrangement includes multiple sensors and utilizing at least one of the first, second and third methods to accumulate sensor signals and determining the operating state of the system.
Code of Federal Regulations, 2011 CFR
2011-10-01
... support or improve: organizational policy development; decision-making; management and administration... organizations, activities (including management and support services for R&D activities), or systems. These..., decision-making, management, or administration. Included are studies in support of R&D activities. Also...
Code of Federal Regulations, 2010 CFR
2010-10-01
... support or improve: organizational policy development; decision-making; management and administration... organizations, activities (including management and support services for R&D activities), or systems. These..., decision-making, management, or administration. Included are studies in support of R&D activities. Also...
NASA Technical Reports Server (NTRS)
Stone, J. E.
1975-01-01
The effects of fuselage cross section and structural arrangement on the performance of actively cooled hypersonic cruise vehicles are investigated. An active cooling system which maintains the aircraft's entire surface area at temperatures below 394 K at Mach 6 is developed along with a hydrogen fuel tankage thermal protection system. Thermodynamic characteristics of the actively cooled thermal protection systems established are summarized. Design heat loads and coolant flowrate requirements are defined for each major structural section and for the total system. Cooling system weights are summarized at the major component level. Conclusions and recommendations are included.
NASA Technical Reports Server (NTRS)
Grantier, David
2003-01-01
This paper presents viewgraphs on the development of the Weather Accident Prevention (WxAP) System architecture and Concept of Operation (CONOPS) activities. The topics include: 1) Background Information on System Architecture/CONOPS Activity; 2) Activity Work in Progress; and 3) Anticipated By-Products.
The Need for V&V in Reuse-Based Software Engineering
NASA Technical Reports Server (NTRS)
Addy, Edward A.
1997-01-01
V&V is currently performed during application development for many systems, especially safety-critical and mission-critical systems. The V&V process is intended to discover errors, especially errors related to entire' domain or product line rather than a critical processing, as early as possible during the development process. The system application provides the context under which the software artifacts are validated. engineering. This paper describes a framework that extends V&V from an individual application system to a product line of systems that are developed within an architecture-based software engineering environment. This framework includes the activities of traditional application-level V&V, and extends these activities into the transition between domain engineering and application engineering. The framework includes descriptions of the types of activities to be performed during each of the life-cycle phases, and provides motivation for activities.
A Low Power, Parallel Wearable Multi-Sensor System for Human Activity Evaluation.
Li, Yuecheng; Jia, Wenyan; Yu, Tianjian; Luan, Bo; Mao, Zhi-Hong; Zhang, Hong; Sun, Mingui
2015-04-01
In this paper, the design of a low power heterogeneous wearable multi-sensor system, built with Zynq System-on-Chip (SoC), for human activity evaluation is presented. The powerful data processing capability and flexibility of this SoC represent significant improvements over our previous ARM based system designs. The new system captures and compresses multiple color images and sensor data simultaneously. Several strategies are adopted to minimize power consumption. Our wearable system provides a new tool for the evaluation of human activity, including diet, physical activity and lifestyle.
Orbiter active thermal control system description
NASA Technical Reports Server (NTRS)
Laubach, G. E.
1975-01-01
A brief description of the Orbiter Active Thermal Control System (ATCS) including (1) major functional requirements of heat load, temperature control and heat sink utilization, (2) the overall system arrangement, and (3) detailed description of the elements of the ATCS.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Young, K.K.; Wilkes, R.J.
1995-11-21
A transponder of an active digital sonar system identifies a multifrequency underwater activating sonar signal received from a remote sonar transmitter. The transponder includes a transducer that receives acoustic waves, including the activating sonar signal, and generates an analog electrical receipt signal. The analog electrical receipt signal is converted to a digital receipt signal and cross-correlated with a digital transmission signal pattern corresponding to the activating sonar signal. A relative peak in the cross-correlation value is indicative of the activating sonar signal having been received by the transponder. In response to identifying the activating sonar signal, the transponder transmits amore » responding multifrequency sonar signal. 4 figs.« less
Moving through the Solar System: Using Movement Activities To Learn about the Solar System.
ERIC Educational Resources Information Center
Nygard, Bonnie; Shaw, Donna Gail
1997-01-01
Presents a rationale for acknowledging the importance of movement to learning to help children understand abstract concepts. Includes seven activities that employ movement to enable students to understand the nature of the solar system. (DDR)
Artist concept illustrating key events on day by day basis during Apollo 9
NASA Technical Reports Server (NTRS)
1969-01-01
Artist concept illustrating key events on day by day basis during Apollo 9 mission. First photograph illustrates activities on the first day of the mission, including flight crew preparation, orbital insertion, 103 north mile orbit, separations, docking and docked Service Propulsion System Burn (19792); Second day events include landmark tracking, pitch maneuver, yaw-roll maneuver, and high apogee orbits (19793); Third day events include crew transfer and Lunar Module system evaluation (19794); Fourth day events include use of camera, day-night extravehicular activity, use of golden slippers, and television over Texas and Louisiana (19795); Fifth day events include vehicles undocked, Lunar Module burns for rendezvous, maximum separation, ascent propulsion system burn, formation flying and docking, and Lunar Module jettison ascent burn (19796); Sixth thru ninth day events include service propulsion system burns and landmark sightings, photograph special tests (19797); Tenth day events i
Global Positioning System Synchronized Active Light Autonomous Docking System
NASA Technical Reports Server (NTRS)
Howard, Richard T. (Inventor); Book, Michael L. (Inventor); Bryan, Thomas C. (Inventor); Bell, Joseph L. (Inventor)
1996-01-01
A Global Positioning System Synchronized Active Light Autonomous Docking System (GPSSALADS) for automatically docking a chase vehicle with a target vehicle comprising at least one active light emitting target which is operatively attached to the target vehicle. The target includes a three-dimensional array of concomitantly flashing lights which flash at a controlled common frequency. The GPSSALADS further comprises a visual tracking sensor operatively attached to the chase vehicle for detecting and tracking the target vehicle. Its performance is synchronized with the flash frequency of the lights by a synchronization means which is comprised of first and second internal clocks operatively connected to the active light target and visual tracking sensor, respectively, for providing timing control signals thereto, respectively. The synchronization means further includes first and second Global Positioning System receivers operatively connected to the first and second internal clocks, respectively, for repeatedly providing simultaneous synchronization pulses to the internal clocks, respectively. In addition, the GPSSALADS includes a docking process controller means which is operatively attached to the chase vehicle and is responsive to the visual tracking sensor for producing commands for the guidance and propulsion system of the chase vehicle.
Global Positioning System Synchronized Active Light Autonomous Docking System
NASA Technical Reports Server (NTRS)
Howard, Richard (Inventor)
1994-01-01
A Global Positioning System Synchronized Active Light Autonomous Docking System (GPSSALADS) for automatically docking a chase vehicle with a target vehicle comprises at least one active light emitting target which is operatively attached to the target vehicle. The target includes a three-dimensional array of concomitantly flashing lights which flash at a controlled common frequency. The GPSSALADS further comprises a visual tracking sensor operatively attached to the chase vehicle for detecting and tracking the target vehicle. Its performance is synchronized with the flash frequency of the lights by a synchronization means which is comprised of first and second internal clocks operatively connected to the active light target and visual tracking sensor, respectively, for providing timing control signals thereto, respectively. The synchronization means further includes first and second Global Positioning System receivers operatively connected to the first and second internal clocks, respectively, for repeatedly providing simultaneous synchronization pulses to the internal clocks, respectively. In addition, the GPSSALADS includes a docking process controller means which is operatively attached to the chase vehicle and is responsive to the visual tracking sensor for producing commands for the guidance and propulsion system of the chase vehicle.
Advanced Docking System With Magnetic Initial Capture
NASA Technical Reports Server (NTRS)
Lewis, James L.; Carroll, Monty B.; Morales, Ray; Le, Thang
2004-01-01
An advanced docking system is undergoing development to enable softer, safer docking than was possible when using prior docking systems. This system is intended for original use in docking of visiting spacecraft and berthing the Crew Return Vehicle at the International Space Station (ISS). The system could also be adapted to a variety of other uses in outer space and on Earth, including mating submersible vehicles, assembling structures, and robotic berthing/handling of payloads and cargo. Heretofore, two large spacecraft have been docked by causing the spacecraft to approach each other at a speed sufficient to activate capture latches - a procedure that results in large docking loads and is made more difficult because of the speed. The basic design and mode of operation of the present advanced docking system would eliminate the need to rely on speed of approach to activate capture latches, thereby making it possible to reduce approach speed and thus docking loads substantially. The system would comprise an active subsystem on one spacecraft and a passive subsystem on another spacecraft with which the active subsystem will be docked. The passive subsystem would include an extensible ring containing magnetic striker plates and guide petals. The active subsystem would include mating guide petals and electromagnets containing limit switches and would be arranged to mate with the magnetic striker plates and guide petals of the passive assembly. The electromagnets would be carried on (but not rigidly attached to) a structural ring that would be instrumented with load sensors. The outputs of the sensors would be sent, along with position information, as feedback to an electronic control subsystem. The system would also include electromechanical actuators that would extend or retract the ring upon command by the control subsystem.
A Framework for Performing Verification and Validation in Reuse Based Software Engineering
NASA Technical Reports Server (NTRS)
Addy, Edward A.
1997-01-01
Verification and Validation (V&V) is currently performed during application development for many systems, especially safety-critical and mission- critical systems. The V&V process is intended to discover errors, especially errors related to critical processing, as early as possible during the development process. The system application provides the context under which the software artifacts are validated. This paper describes a framework that extends V&V from an individual application system to a product line of systems that are developed within an architecture-based software engineering environment. This framework includes the activities of traditional application-level V&V, and extends these activities into domain engineering and into the transition between domain engineering and application engineering. The framework includes descriptions of the types of activities to be performed during each of the life-cycle phases, and provides motivation for the activities.
ERIC Educational Resources Information Center
Biomedical Interdisciplinary Curriculum Project, Berkeley, CA.
Designed to accompany the student text on the nervous system, this manual presents laboratory activities dealing with concepts presented in the text. Thirty-seven activities are described. Four supplementary activities dealing with concepts in electricity are also included. Laboratory activities are divided into several parts, each part covering a…
Space Station Human Factors Research Review. Volume 1: EVA Research and Development
NASA Technical Reports Server (NTRS)
Cohen, Marc M. (Editor); Vykukal, H. C. (Editor)
1988-01-01
An overview is presented of extravehicular activity (EVA) research and development activities at Ames. The majority of the program was devoted to presentations by the three contractors working in parallel on the EVA System Phase A Study, focusing on Implications for Man-Systems Design. Overhead visuals are included for a mission results summary, space station EVA requirements and interface accommodations summary, human productivity study cross-task coordination, and advanced EVAS Phase A study implications for man-systems design. Articles are also included on subsea approach to work systems development and advanced EVA system design requirements.
High Flight. Aerospace Activities, K-12.
ERIC Educational Resources Information Center
Oklahoma State Dept. of Education, Oklahoma City.
Following discussions of Oklahoma aerospace history and the history of flight, interdisciplinary aerospace activities are presented. Each activity includes title, concept fostered, purpose, list of materials needed, and procedure(s). Topics include planets, the solar system, rockets, airplanes, air travel, space exploration, principles of flight,…
Occupational Information Systems and Their Use in Rehabilitation. Revised.
ERIC Educational Resources Information Center
Kruger, Reuven
As our industrial-based economy changes into an information-based economy, information activities will continue to permeate rehabilitation. New technology in this area includes computerized occupational information systems used to aid vocational planning. Such systems include the federal government's Job Service Matching System, the Michigan…
DOT National Transportation Integrated Search
1997-06-04
The scope of CVO includes the operations associated with moving goods and passengers via commercial vehicles over the North American highway system and the activities necessary to regulate these operations. It includes activities related to safety as...
Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs.
Andrews, Steven S; Peria, William J; Yu, Richard C; Colman-Lerner, Alejandro; Brent, Roger
2016-11-23
Many cell signaling systems, including the yeast pheromone response system, exhibit "dose-response alignment" (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including "push-pull" mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control. Copyright © 2016 Elsevier Inc. All rights reserved.
ATTDES: An Expert System for Satellite Attitude Determination and Control. 2
NASA Technical Reports Server (NTRS)
Mackison, Donald L.; Gifford, Kevin
1996-01-01
The design, analysis, and flight operations of satellite attitude determintion and attitude control systems require extensive mathematical formulations, optimization studies, and computer simulation. This is best done by an analyst with extensive education and experience. The development of programs such as ATTDES permit the use of advanced techniques by those with less experience. Typical tasks include the mission analysis to select stabilization and damping schemes, attitude determination sensors and algorithms, and control system designs to meet program requirements. ATTDES is a system that includes all of these activities, including high fidelity orbit environment models that can be used for preliminary analysis, parameter selection, stabilization schemes, the development of estimators covariance analyses, and optimization, and can support ongoing orbit activities. The modification of existing simulations to model new configurations for these purposes can be an expensive, time consuming activity that becomes a pacing item in the development and operation of such new systems. The use of an integrated tool such as ATTDES significantly reduces the effort and time required for these tasks.
40 CFR 63.7535 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2014 CFR
2014-07-01
...-control periods, or required monitoring system quality assurance or control activities in data averages... required monitoring system quality assurance or quality control activities (including, as applicable... control activities. You must calculate monitoring results using all other monitoring data collected while...
40 CFR 63.7535 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2013 CFR
2013-07-01
...-control periods, or required monitoring system quality assurance or control activities in data averages... required monitoring system quality assurance or quality control activities (including, as applicable... control activities. You must calculate monitoring results using all other monitoring data collected while...
20 CFR 641.856 - What functions and activities constitute administrative costs?
Code of Federal Regulations, 2012 CFR
2012-04-01
..., including: (i) Accounting, budgeting, financial, and cash management functions; (ii) Procurement and... management, accounting, and payroll systems) including the purchase, systems development, and operating costs of such systems and; (6) Costs of technical assistance, professional organization membership dues...
20 CFR 641.856 - What functions and activities constitute administrative costs?
Code of Federal Regulations, 2014 CFR
2014-04-01
..., including: (i) Accounting, budgeting, financial, and cash management functions; (ii) Procurement and... management, accounting, and payroll systems) including the purchase, systems development, and operating costs of such systems and; (6) Costs of technical assistance, professional organization membership dues...
20 CFR 641.856 - What functions and activities constitute administrative costs?
Code of Federal Regulations, 2011 CFR
2011-04-01
..., including: (i) Accounting, budgeting, financial, and cash management functions; (ii) Procurement and... management, accounting, and payroll systems) including the purchase, systems development, and operating costs of such systems and; (6) Costs of technical assistance, professional organization membership dues...
20 CFR 641.856 - What functions and activities constitute administrative costs?
Code of Federal Regulations, 2013 CFR
2013-04-01
..., including: (i) Accounting, budgeting, financial, and cash management functions; (ii) Procurement and... management, accounting, and payroll systems) including the purchase, systems development, and operating costs of such systems and; (6) Costs of technical assistance, professional organization membership dues...
Impact on quality activities of measurement systems meeting an L:1 rule
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hamada, M. S.; Burkhardt, J. H.
2016-04-01
This study considers the impact of a measurement system that meets an L:1 rule on various quality activities. These activities include inspection, acceptance sampling, and control charting. A measurement system that meets a 10:1 rule performs much better than one that meets a 4:1 rule. R code is provided so that the practitioner is able to evaluate these activities to his or her particular situation.
JPL Activated Carbon Treatment System (ACTS) for sewage
NASA Technical Reports Server (NTRS)
1976-01-01
An Activated Carbon Treatment System (ACTS) was developed for sewage treatment and is being applied to a one-million gallon per day sewage treatment pilot plant in Orange County California. Activities reported include pyrolysis and activation of carbon-sewage sludge, and activated carbon treatment of sewage to meet ocean discharge standards. The ACTS Sewage treatment operations include carbon-sewage treatment, primary and secondary clarifiers, gravity (multi-media) filter, filter press dewatering, flash drying of carbon-sewage filter cake, and sludge pyrolysis and activation. Tests were conducted on a laboratory scale, 10,000 gallon per day demonstration plant and pilot test equipment. Preliminary economic studies are favorable to the ACTS process relative to activated sludge treatment for a 175,000,000 gallon per day sewage treatment plant.
Advanced EVA system design requirements study
NASA Technical Reports Server (NTRS)
1986-01-01
Design requirements and criteria for the Space Station Advanced Extravehicular Activity System (EVAS) including crew enclosures, portable life support systems, maneuvering propulsion systems, and related extravehicular activity (EVA) support equipment were defined and established. The EVA mission requirements, environments, and medical and physiological requirements, as well as opertional, procedures, and training issues were considered.
Adding Value to the Health Care System: Identifying Value-Added Systems Roles for Medical Students.
Gonzalo, Jed D; Graaf, Deanna; Johannes, Bobbie; Blatt, Barbara; Wolpaw, Daniel R
To catalyze learning in Health Systems Science and add value to health systems, education programs are seeking to incorporate students into systems roles, which are not well described. The authors sought to identify authentic roles for students within a range of clinical sites and explore site leaders' perceptions of the value of students performing these roles. From 2013 to 2015, site visits and interviews with leadership from an array of clinical sites (n = 30) were conducted. Thematic analysis was used to identify tasks and benefits of integrating students into interprofessional care teams. Types of systems roles included direct patient benefit activities, including monitoring patient progress with care plans and facilitating access to resources, and clinic benefit activities, including facilitating coordination and improving clinical processes. Perceived benefits included improved value of the clinical mission and enhanced student education. These results elucidate a framework for student roles that enhance learning and add value to health systems.
The Adaptive Optics Summer School Laboratory Activities
NASA Astrophysics Data System (ADS)
Ammons, S. M.; Severson, S.; Armstrong, J. D.; Crossfield, I.; Do, T.; Fitzgerald, M.; Harrington, D.; Hickenbotham, A.; Hunter, J.; Johnson, J.; Johnson, L.; Li, K.; Lu, J.; Maness, H.; Morzinski, K.; Norton, A.; Putnam, N.; Roorda, A.; Rossi, E.; Yelda, S.
2010-12-01
Adaptive Optics (AO) is a new and rapidly expanding field of instrumentation, yet astronomers, vision scientists, and general AO practitioners are largely unfamiliar with the root technologies crucial to AO systems. The AO Summer School (AOSS), sponsored by the Center for Adaptive Optics, is a week-long course for training graduate students and postdoctoral researchers in the underlying theory, design, and use of AO systems. AOSS participants include astronomers who expect to utilize AO data, vision scientists who will use AO instruments to conduct research, opticians and engineers who design AO systems, and users of high-bandwidth laser communication systems. In this article we describe new AOSS laboratory sessions implemented in 2006-2009 for nearly 250 students. The activity goals include boosting familiarity with AO technologies, reinforcing knowledge of optical alignment techniques and the design of optical systems, and encouraging inquiry into critical scientific questions in vision science using AO systems as a research tool. The activities are divided into three stations: Vision Science, Fourier Optics, and the AO Demonstrator. We briefly overview these activities, which are described fully in other articles in these conference proceedings (Putnam et al., Do et al., and Harrington et al., respectively). We devote attention to the unique challenges encountered in the design of these activities, including the marriage of inquiry-like investigation techniques with complex content and the need to tune depth to a graduate- and PhD-level audience. According to before-after surveys conducted in 2008, the vast majority of participants found that all activities were valuable to their careers, although direct experience with integrated, functional AO systems was particularly beneficial.
Active pharmacovigilance in China: recent development and future perspectives.
Li, Xinling; Li, Haona; Deng, Jianxiong; Zhu, Feng; Liu, Ying; Chen, Wenge; Yue, Zhihua; Ren, Xuequn; Xia, Jielai
2018-04-10
The effectiveness of active pharmacovigilance depends on the specific methods adopted and the work patterns put into place. Over the past few years, much attention has been paid to the importance of implementing such systems in China. However, less has been done to evaluate the state of implementation and future needs of such systems. This paper reviews China's recent approaches to active pharmacovigilance by examining: (1) information collected from scientific articles and the websites of the China Food and Drug Administration and the China National Center for Adverse Drug Reaction Monitoring, (2) information available on China's spontaneous reporting systems (SRS) and active pharmacovigilance system, and (3) annual reports and internal reports on this subject. Areas that improved most meaningfully for China's active pharmacovigilance in recent years appear to include: (1) quicker reporting and more intelligent scanning methods for adverse drug reactions (ADRs), (2) the use of pharmacovigilance approaches to mine electronic hospital records, and (3) the development of integrated systems including the China Hospital Pharmacovigilance System and China Sentinel Hospital Alliance Program. Not only has the national online SRS system provided a platform for passive pharmacovigilance, it has also become an important platform for various explorations of active pharmacovigilance in China. Quick reporting and intelligent scanning of ADRs, facilitated by automated ADR detection based on electronic hospital records, have accelerated to capabilities for active pharmacovigilance. The outcomes of the programs, such as the China Hospital Pharmacovigilance System and China Sentinel Hospital Alliance Program, usher in a new era for China's active pharmacovigilance. These are particularly important to bridge the information system of sentinel hospitals and ADR research centers, but gaps remain. Thus, much work needs to be done before a high-level active pharmacovigilance system is sufficiently mature to ensure drug safety in the country.
Human factors aspects of air traffic control
NASA Technical Reports Server (NTRS)
Older, H. J.; Cameron, B. J.
1972-01-01
An overview of human factors problems associated with the operation of present and future air traffic control systems is presented. A description is included of those activities and tasks performed by air traffic controllers at each operational position within the present system. Judgemental data obtained from controllers concerning psychological dimensions related to these tasks and activities are also presented. The analysis includes consideration of psychophysiological dimensions of human performance. The role of the human controller in present air traffic control systems and his predicted role in future systems is described, particularly as that role changes as the result of the system's evolution towards a more automated configuration. Special attention is directed towards problems of staffing, training, and system operation. A series of ten specific research and development projects are recommended and suggested work plans for their implementation are included.
DOT National Transportation Integrated Search
2008-12-01
Programmable logic controllers (PLCs) were installed at several key ramps with the assistance of the City of Portland and used to capture additional data about ramp operations that are not otherwise logged. The data include include the activation and...
Toxin activity assays, devices, methods and systems therefor
Koh, Chung-Yan; Schaff, Ulrich Y.; Sommer, Gregory Jon
2016-04-05
Embodiments of the present invention are directed toward devices, system and method for conducting toxin activity assay using sedimentation. The toxin activity assay may include generating complexes which bind to a plurality of beads in a fluid sample. The complexes may include a target toxin and a labeling agent, or may be generated due to presence of active target toxin and/or labeling agent designed to be incorporated into complexes responsive to the presence of target active toxin. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a lower density than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
Inductively heated particulate matter filter regeneration control system
Gonze, Eugene V; Paratore Jr., Michael J; Kirby, Kevin W; Phelps, Amanda; Gregoire, Daniel J
2012-10-23
A system includes a particulate matter (PM) filter with an upstream end for receiving exhaust gas, a downstream end and zones. The system also includes a heating element. A control module selectively activates the heating element to inductively heat one of the zones.
Thermal Technology Development Activities at the Goddard Space Flight Center - 2001
NASA Technical Reports Server (NTRS)
Butler, Dan
2002-01-01
This presentation provides an overview of thermal technology development activities carried out at NASA's Goddard Space Flight Center during 2001. Specific topics covered include: two-phase systems (heat pipes, capillary pumped loops, vapor compression systems and phase change materials), variable emittance systems, advanced coatings, high conductivity materials and electrohydrodynamic (EHD) thermal coatings. The application of these activities to specific space missions is also discussed.
Weld analysis and control system
NASA Technical Reports Server (NTRS)
Kennedy, Larry Z. (Inventor); Rodgers, Michael H. (Inventor); Powell, Bradley W. (Inventor); Burroughs, Ivan A. (Inventor); Goode, K. Wayne (Inventor)
1994-01-01
The invention is a Weld Analysis and Control System developed for active weld system control through real time weld data acquisition. Closed-loop control is based on analysis of weld system parameters and weld geometry. The system is adapted for use with automated welding apparatus having a weld controller which is capable of active electronic control of all aspects of a welding operation. Enhanced graphics and data displays are provided for post-weld analysis. The system provides parameter acquisition, including seam location which is acquired for active torch cross-seam positioning. Torch stand-off is also monitored for control. Weld bead and parent surface geometrical parameters are acquired as an indication of weld quality. These parameters include mismatch, peaking, undercut, underfill, crown height, weld width, puddle diameter, and other measurable information about the weld puddle regions, such as puddle symmetry, etc. These parameters provide a basis for active control as well as post-weld quality analysis and verification. Weld system parameters, such as voltage, current and wire feed rate, are also monitored and archived for correlation with quality parameters.
Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-25
... Nervous System Proteinopathies, Including Parkinson's Disease AGENCY: National Institutes of Health... limited to ``Treatment of Gaucher disease and human central nervous system proteinopathies, including...
DOT National Transportation Integrated Search
1976-08-01
The overall objective of this research is to measure usage of, and attitudes toward, the passive restraint system, compared with the active restraint system on 1975 model year Volkswagen Rabbits. Methods used to carry out the research include: Interv...
Teaching Case: A Systems Analysis Role-Play Exercise and Assignment
ERIC Educational Resources Information Center
Mitri, Michel; Cole, Carey; Atkins, Laura
2017-01-01
This paper presents a role-play exercise and assignment that provides an active learning experience related to the system investigation phase of an SDLC. Whether using waterfall or agile approaches, the first SDLC step usually involves system investigation activities, including problem identification, feasibility study, cost-benefit analysis, and…
The Development of Strategic Thinking: Learning to Impact Human Systems in a Youth Activism Program
ERIC Educational Resources Information Center
Larson, Reed; Hansen, David
2005-01-01
Human systems, including institutional systems and informal social networks, are a major arena of modern life. We argue that distinct forms of pragmatic reasoning or "strategic thinking" are required to exercise agency within such systems. This article explores the development of strategic thinking in a youth activism program in which young people…
Gestational outcomes in patients with neuropsychiatric systemic lupus erythematosus.
de Jesus, G R; Rodrigues, B C; Lacerda, M I; Dos Santos, F C; de Jesus, N R; Klumb, E M; Levy, R A
2017-04-01
This study analyzed maternal and fetal outcomes of pregnancies of neuropsychiatric systemic lupus erythematosus patients followed in a reference unit. This retrospective cohort study included 26 pregnancies of patients seen between 2011 and 2015 included with history and/or active neuropsychiatric systemic lupus erythematosus among 135 pregnancies. Three patients had active neuropsychiatric systemic lupus erythematosus at conception, but only one remained with neurological activity during gestation, characteristically related to the inadvertent suspension of medications. Twenty six percent of the newborns were small for gestational age and 40% of live births were premature, with no neonatal death or early complications of prematurity. Preeclampsia was diagnosed in nine pregnancies, with two cases of early severe form that resulted in intrauterine fetal death. Patients with neuropsychiatric systemic lupus erythematosus had more prematurity and preeclampsia compared to patients without neuropsychiatric disease. However, when concomitant lupus nephritis was excluded, the gestational results of neuropsychiatric systemic lupus erythematosus patients were more favorable.
Static and Dynamic Aeroelastic Tailoring With Variable Camber Control
NASA Technical Reports Server (NTRS)
Stanford, Bret K.
2016-01-01
This paper examines the use of a Variable Camber Continuous Trailing Edge Flap (VCCTEF) system for aeroservoelastic optimization of a transport wingbox. The quasisteady and unsteady motions of the flap system are utilized as design variables, along with patch-level structural variables, towards minimizing wingbox weight via maneuver load alleviation and active flutter suppression. The resulting system is, in general, very successful at removing structural weight in a feasible manner. Limitations to this success are imposed by including load cases where the VCCTEF system is not active (open-loop) in the optimization process, and also by including actuator operating cost constraints.
Integral isolation valve systems for loss of coolant accident protection
Kanuch, David J.; DiFilipo, Paul P.
2018-03-20
A nuclear reactor includes a nuclear reactor core comprising fissile material disposed in a reactor pressure vessel having vessel penetrations that exclusively carry flow into the nuclear reactor and at least one vessel penetration that carries flow out of the nuclear reactor. An integral isolation valve (IIV) system includes passive IIVs each comprising a check valve built into a forged flange and not including an actuator, and one or more active IIVs each comprising an active valve built into a forged flange and including an actuator. Each vessel penetration exclusively carrying flow into the nuclear reactor is protected by a passive IIV whose forged flange is directly connected to the vessel penetration. Each vessel penetration carrying flow out of the nuclear reactor is protected by an active IIV whose forged flange is directly connected to the vessel penetration. Each active valve may be a normally closed valve.
Active polar two-fluid macroscopic dynamics.
Pleiner, H; Svenšek, D; Brand, H R
2013-11-01
We study the dynamics of systems with a polar dynamic preferred direction. Examples include the pattern-forming growth of bacteria as well as shoals of fish, flocks of birds and migrating insects. Due to the fact that the preferred direction only exists dynamically, but not statically, the macroscopic variable of choice is the macroscopic velocity associated with the motion of the active units, which are typically biological in nature. We derive the macroscopic equations for such a system and discuss novel static, reversible and irreversible cross-couplings connected to a second velocity as a variable. We analyze in detail how the macroscopic behavior of an active system with a polar dynamic preferred direction compares to other systems with two velocities including immiscible liquids and electrically neutral quantum liquids such as superfluid (4)He and (3)He . We critically discuss changes in the normal mode spectrum when comparing uncharged superfluids, immiscible liquids and active system with a polar dynamic preferred direction. We investigate the influence of a macroscopic hand (collective effects of chirality) on the macroscopic behavior of such active media.
Applications of CRISPR/Cas System to Bacterial Metabolic Engineering.
Cho, Suhyung; Shin, Jongoh; Cho, Byung-Kwan
2018-04-05
The clustered regularly interspaced short palindromic repeats/CRISPR-associated (CRISPR/Cas) adaptive immune system has been extensively used for gene editing, including gene deletion, insertion, and replacement in bacterial and eukaryotic cells owing to its simple, rapid, and efficient activities in unprecedented resolution. Furthermore, the CRISPR interference (CRISPRi) system including deactivated Cas9 (dCas9) with inactivated endonuclease activity has been further investigated for regulation of the target gene transiently or constitutively, avoiding cell death by disruption of genome. This review discusses the applications of CRISPR/Cas for genome editing in various bacterial systems and their applications. In particular, CRISPR technology has been used for the production of metabolites of high industrial significance, including biochemical, biofuel, and pharmaceutical products/precursors in bacteria. Here, we focus on methods to increase the productivity and yield/titer scan by controlling metabolic flux through individual or combinatorial use of CRISPR/Cas and CRISPRi systems with introduction of synthetic pathway in industrially common bacteria including Escherichia coli . Further, we discuss additional useful applications of the CRISPR/Cas system, including its use in functional genomics.
Activity-dependent self-regulation of viscous length scales in biological systems
NASA Astrophysics Data System (ADS)
Nandi, Saroj Kumar
2018-05-01
The cellular cortex, which is a highly viscous thin cytoplasmic layer just below the cell membrane, controls the cell's mechanical properties, which can be characterized by a hydrodynamic length scale ℓ . Cells actively regulate ℓ via the activity of force-generating molecules, such as myosin II. Here we develop a general theory for such systems through a coarse-grained hydrodynamic approach including activity in the static description of the system providing an experimentally accessible parameter and elucidate the detailed mechanism of how a living system can actively self-regulate its hydrodynamic length scale, controlling the rigidity of the system. Remarkably, we find that ℓ , as a function of activity, behaves universally and roughly inversely proportional to the activity of the system. Our theory rationalizes a number of experimental findings on diverse systems, and comparison of our theory with existing experimental data shows good agreement.
Mobile Robotics Activities in DOE Laboratories
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ron Lujan; Jerry Harbour; John T. Feddema
This paper will briefly outline major activities in Department of Energy (DOE) Laboratories focused on mobile platforms, both Unmanned Ground Vehicles (UGV’s) as well as Unmanned Air Vehicles (UAV’s). The activities will be discussed in the context of the science and technology construct used by the DOE Technology Roadmap for Robotics and Intelligent Machines (RIM)1 published in 1998; namely, Perception, Reasoning, Action, and Integration. The activities to be discussed span from research and development to deployment in field operations. The activities support customers in other agencies. The discussion of "perception" will include hyperspectral sensors, complex patterns discrimination, multisensor fusion andmore » advances in LADAR technologies, including real-world perception. "Reasoning" activities to be covered include cooperative controls, distributed systems, ad-hoc networks, platform-centric intelligence, and adaptable communications. The paper will discuss "action" activities such as advanced mobility and various air and ground platforms. In the RIM construct, "integration" includes the Human-Machine Integration. Accordingly the paper will discuss adjustable autonomy and the collaboration of operator(s) with distributed UGV’s and UAV’s. Integration also refers to the applications of these technologies into systems to perform operations such as perimeter surveillance, large-area monitoring and reconnaissance. Unique facilities and test beds for advanced mobile systems will be described. Given that this paper is an overview, rather than delve into specific detail in these activities, other more exhaustive references and sources will be cited extensively.« less
Evoluton of the Tharsis Region of Mars
NASA Astrophysics Data System (ADS)
Anderson, R. C.; Dohm, J. M.; Maruyama, S.
2015-12-01
The evolution of the Tharsis region includes at least five major stages of Tharsis-related activity, which includes the formation of igneous plateaus, canyon and fault systems, volcanoes, and centers of magmatic-driven tectonism. This activity drove major environmental changes that were recorded in the walls of Valles Marineris, the circum-Chryse outflow channel system, the northern plains, and impact basins such as Argyre, among many other Martian features and landscapes. Environmental change included flooding and associated formation of lakes and oceans in basins such as the prominent northern plains and impact basins such as Argyre. This Tharsis-driven activity also included the formation of glaciers in the southern hemisphere and other landscape features (e.g., alluvial fans, periglacial landforms, gelifluction features including mass wasting, fluvial channels) indicative of an active landscape. At this conference, we will present the details of the evolution of Tharsis, as well as discuss contributing factors to its origin, estimated beginning development, and explanations for its longevity.
Survey of Active Vibration Isolation Systems for Microgravity Applications
NASA Technical Reports Server (NTRS)
Grodsinsky, Carlos M.; Whorton, Mark S.
2000-01-01
In view of the utility of space vehicles as orbiting science laboratories, the need for vibration isolation systems for acceleration-sensitive experiments has gained increasing visibility. To date, three active microgravity vibration isolation systems have successfully been demonstrated in flight. A tutorial discussion of the microgravity vibration isolation problem, including a description of the acceleration environment of the International Space Station and attenuation requirements, as well as a comparison or the dynamics of passive isolation, active rack-level isolation, and active payload-level isolation is provided. The flight test results of the three demonstrated systems: suppression of transient accelerations by levitation, the microgravity vibration isolation mount, and the active rack isolation system are surveyed.
Tractor Mechanics: Maintaining and Servicing the Fuel System. Learning Activity Packages 20-33.
ERIC Educational Resources Information Center
Clemson Univ., SC. Vocational Education Media Center.
Learning activity packages are presented for instruction in tractor mechanics. The packages deal with the duties involved in maintaining the fuel system. The following fourteen learning activity packages are included: servicing fuel and air filters, servicing fuel tanks and lines, adjusting a carburetor, servicing a carburetor, servicing the…
A Practical Application of Microcomputers to Control an Active Solar System.
ERIC Educational Resources Information Center
Goldman, David S.; Warren, William
1984-01-01
Describes the design and implementation of a microcomputer-based model active solar heating system. Includes discussions of: (1) the active solar components (solar collector, heat exchanger, pump, and fan necessary to provide forced air heating); (2) software components; and (3) hardware components (in the form of sensors and actuators). (JN)
The Brain in Space: A Teacher's Guide with Activities for Neuroscience.
ERIC Educational Resources Information Center
MacLeish, Marlene Y.; McLean, Bernice R.
This educators guide discusses the brain and contains activities on neuroscience. Activities include: (1) "The Space Life Sciences"; (2) "Space Neuroscience: A Special Area within the Space Life Sciences"; (3) "Space Life Sciences Research"; (4) "Neurolab: A Special Space Mission to Study the Nervous System"; (5) "The Nervous System"; (6)…
USDA-ARS?s Scientific Manuscript database
Furan fatty acids (F-acids) gain special attentions since they are known to play important roles in biological systems including humans. Specifically F-acids are known to have strong antioxidant activity like radical scavenging activity. Although widely distributed in most biological systems, F-ac...
NASA Technical Reports Server (NTRS)
1974-01-01
System design and performance of the Skylab Airlock Module and Payload Shroud are presented for the communication and caution and warning systems. Crew station and storage, crew trainers, experiments, ground support equipment, and system support activities are also reviewed. Other areas documented include the reliability and safety programs, test philosophy, engineering project management, and mission operations support.
Development and testing of heat transport fluids for use in active solar heating and cooling systems
NASA Technical Reports Server (NTRS)
Parker, J. C.
1981-01-01
Work on heat transport fluids for use with active solar heating and cooling systems is described. Program objectives and how they were accomplished including problems encountered during testing are discussed.
Instructive Video Retrieval for Surgical Skill Coaching Using Attribute Learning
2015-06-28
dance, sports, and surgery training. Most existing systems are either passive (for data capture only) or barely active (with limited automated...including dance, sports, and surgery training. Most existing systems are either passive (for data capture only) or barely active (with limited...sports, and surgery training. Most existing systems are either passive (for data capture only) or barely active (with limited automated feed- back to a
An Ethical Governor for Constraining Lethal Action in an Autonomous System
2009-01-01
property is prohibited from being attacked, including buildings dedicated to religion, art , science … Activity Active Logical Form TargetDiscriminated...attacked, including buildings dedicated to religion, art , science , charitable purposes, and historic monuments. Prohibition LOW Civilian
Disordered anodes for Ni-metal rechargeable battery
Young, Kwo-hsiung; Wang, Lixin; Mays, William C.
2016-11-22
An electrochemical cell is provided that includes a structurally and compositionally disordered electrochemically active alloy material as an anode active material with unexpected capacity against a nickel hydroxide based cathode active material. The disordered metal hydroxide alloy includes three or more transition metal elements and is formed in such a way so as to produce the necessary disorder in the overall system. When an anode active material includes nickel as a predominant, the resulting cells represent the first demonstration of a functional Ni/Ni cell.
Phase Transitions in Model Active Systems
NASA Astrophysics Data System (ADS)
Redner, Gabriel S.
The amazing collective behaviors of active systems such as bird flocks, schools of fish, and colonies of microorganisms have long amazed scientists and laypeople alike. Understanding the physics of such systems is challenging due to their far-from-equilibrium dynamics, as well as the extreme diversity in their ingredients, relevant time- and length-scales, and emergent phenomenology. To make progress, one can categorize active systems by the symmetries of their constituent particles, as well as how activity is expressed. In this work, we examine two categories of active systems, and explore their phase behavior in detail. First, we study systems of self-propelled spherical particles moving in two dimensions. Despite the absence of an aligning interaction, this system displays complex emergent dynamics, including phase separation into a dense active solid and dilute gas. Using simulations and analytic modeling, we quantify the phase diagram and separation kinetics. We show that this nonequilibrium phase transition is analogous to an equilibrium vapor-liquid system, with binodal and spinodal curves and a critical point. We also characterize the dense active solid phase, a unique material which exhibits the structural signatures of a crystalline solid near the crystal-hexatic transition point, as well as anomalous dynamics including superdiffusive motion on intermediate timescales. We also explore the role of interparticle attraction in this system. We demonstrate that attraction drastically changes the phase diagram, which contains two distinct phase-separated regions and is reentrant as a function of propulsion speed. We interpret this complex situation with a simple kinetic model, which builds from the observed microdynamics of individual particles to a full description of the macroscopic phase behavior. We also study active nematics, liquid crystals driven out of equilibrium by energy-dissipating active stresses. The equilibrium nematic state is unstable in these materials, leading to beautiful and surprising behaviors including the spontaneous generation of topological defect pairs which stream through the system and later annihilate, yielding a complex, seemingly chaotic dynamical steady-state. Here, we describe the emergence of order from this chaos in the form of previously unknown broken-symmetry phases in which the topological defects themselves undergo orientational ordering. We have identified these defect-ordered phases in two realizations of an active nematic: first, a suspension of extensile bundles of microtubules and molecular motor proteins, and second, a computational model of extending hard rods. We will describe the defect-stabilized phases that manifest in these systems, our current understanding of their origins, and discuss whether such phases may be a general feature of extensile active nematics.
Performance evaluation of a semi-active cladding connection for multi-hazard mitigation
NASA Astrophysics Data System (ADS)
Gong, Yongqiang; Cao, Liang; Micheli, Laura; Laflamme, Simon; Quiel, Spencer; Ricles, James
2018-03-01
A novel semi-active damping device termed Variable Friction Cladding Connection (VFCC) has been previously proposed to leverage cladding systems for the mitigation of natural and man-made hazards. The VFCC is a semi-active friction damper that connects cladding elements to the structural system. The friction force is generated by sliding plates and varied using an actuator through a system of adjustable toggles. The dynamics of the device has been previously characterized in a laboratory environment. In this paper, the performance of the VFCC at mitigating non-simultaneous multi-hazard excitations that includes wind and seismic loads is investigated on a simulated benchmark building. Simulations consider the robustness with respect to some uncertainties, including the wear of the friction surfaces and sensor failure. The performance of the VFCC is compared against other connection strategies including traditional stiffness, passive viscous, and passive friction elements. Results show that the VFCC is robust and capable of outperforming passive systems for the mitigation of multiple hazards.
Integrating Multiple Space Ground Sensors to Track Volcanic Activity
NASA Technical Reports Server (NTRS)
Chien, Steve; Davies, Ashley; Doubleday, Joshua; Tran, Daniel; Jones, Samuel; Kjartansson, Einar; Thorsteinsson, Hrobjartur; Vogfjord, Kristin; Guomundsson, Magnus; Thordarson, Thor;
2011-01-01
Volcanic activity can occur with little or no warning. Increasing numbers of space borne assets can enable coordinated measurements of volcanic events to enhance both scientific study and hazard response. We describe the use of space and ground measurements to target further measurements as part of a worldwide volcano monitoring system. We utilize a number of alert systems including the MODVOLC, GOESVOLC, US Air Force Weather Advisory, and Volcanic Ash Advisory Center (VAAC) alert systems. Additionally we use in-situ data from ground instrumentation at a number of volcanic sites, including Iceland.
On-Orbit Checkout and Activation of the ISS Oxygen Generation System
NASA Technical Reports Server (NTRS)
Bagdigian, Robert M.; Prokhorov, Kimberlee S.
2007-01-01
NASA has developed and; deployed an Oxygen Generation System (OGS) into the Destiny Module of the International Space Station (ISS). The major. assembly; included in this system is the Oxygen Generator Assembly. (OGA) which was developed under NASA contract by Hamilton Sundstrand Space Systems International (HSSSI), Inc. This paper summarizes the installation of the system into the Destiny Module, its initial checkout and periodic preventative maintenance activities, and its operational activation. Trade studies and analyses that were conducted with the goal of mitigating on-orbit operational risks are also discussed.
Give Customers What They Meant To Ask For--Designing Training Systems at Three Levels.
ERIC Educational Resources Information Center
Hybert, Peter R.
2001-01-01
Examines instructional systems design in light of training and performance technology. Topics include the nature of design; categories of stakeholders; three levels of instructional systems design, including Curriculum Architecture Design, instructional process design, and user interface/instructional activity design; and design goals. (LRW)
Aircraft operations classification system : technical summary.
DOT National Transportation Integrated Search
1999-07-01
In this project, we consider the development and deployment of systems for measuring aircraft activity at airports. This would include determining the type of aircraft and the type of aircraft activity. The type of aircraft is a basic type such as he...
Development of an aircraft operation classification system for Louisiana's airports.
DOT National Transportation Integrated Search
2003-06-01
In this project the development and deployment of systems measuring aircraft activity at airports is considered. This includes determining the type of aircraft and the type of aircraft activity. The type of aircraft is basic such as helicopter, singl...
Advanced adaptive optics technology development
NASA Astrophysics Data System (ADS)
Olivier, Scot S.
2002-02-01
The NSF Center for Adaptive Optics (CfAO) is supporting research on advanced adaptive optics technologies. CfAO research activities include development and characterization of micro-electro-mechanical systems (MEMS) deformable mirror (DM) technology, as well as development and characterization of high-resolution adaptive optics systems using liquid crystal (LC) spatial light modulator (SLM) technology. This paper presents an overview of the CfAO advanced adaptive optics technology development activities including current status and future plans.
Chen, Dong; Giampapa, Mark; Heidelberger, Philip; Ohmacht, Martin; Satterfield, David L; Steinmacher-Burow, Burkhard; Sugavanam, Krishnan
2013-05-21
A system and method for enhancing performance of a computer which includes a computer system including a data storage device. The computer system includes a program stored in the data storage device and steps of the program are executed by a processer. The processor processes instructions from the program. A wait state in the processor waits for receiving specified data. A thread in the processor has a pause state wherein the processor waits for specified data. A pin in the processor initiates a return to an active state from the pause state for the thread. A logic circuit is external to the processor, and the logic circuit is configured to detect a specified condition. The pin initiates a return to the active state of the thread when the specified condition is detected using the logic circuit.
NASA Technical Reports Server (NTRS)
LaPointe, Michael
2006-01-01
The Solar Electric Propulsion (SEP) technology area is tasked to develop near and mid-term SEP technology to improve or enable science mission capture while minimizing risk and cost to the end user. The solar electric propulsion investments are primarily driven by SMD cost-capped mission needs. The technology needs are determined partially through systems analysis tasks including the recent "Re-focus Studies" and "Standard Architecture Study." These systems analysis tasks transitioned the technology development to address the near term propulsion needs suitable for cost-capped open solicited missions such as Discovery and New Frontiers Class missions. Major SEP activities include NASA's Evolutionary Xenon Thruster (NEXT), implementing a Standard Architecture for NSTAR and NEXT EP systems, and developing a long life High Voltage Hall Accelerator (HiVHAC). Lower level investments include advanced feed system development and xenon recovery testing. Future plans include completion of ongoing ISP development activities and evaluating potential use of commercial electric propulsion systems for SMD applications. Examples of enhanced mission capability and technology readiness dates shall be discussed.
Design and evaluation of active cooling systems for Mach 6 cruise vehicle wings
NASA Technical Reports Server (NTRS)
Mcconarty, W. A.; Anthony, F. M.
1971-01-01
Active cooling systems, which included transpiration, film, and convective cooling concepts, are examined. Coolants included hydrogen, helium, air, and water. Heat shields, radiation barriers, and thermal insulation are considered to reduce heat flow to the cooling systems. Wing sweep angles are varied from 0 deg to 75 deg and wing leading edge radii of 0.05 inch and 2.0 inches are examined. Structural temperatures are varied to allow comparison of aluminum alloy, titanium alloy, and superalloy structural materials. Cooled wing concepts are compared among themselves, and with the uncooled concept on the basis of structural weight, cooling system weight, and coolant weight.
ERIC Educational Resources Information Center
Urban, Jennifer Brown; Lewin-Bizan, Selva; Lerner, Richard M.
2009-01-01
Developmental system theories recognize that variables from multiple levels of organization within the bioecology of human development contribute to adolescent development, including individual factors, family factors and the neighborhood which includes extracurricular activities. Extracurricular activities provide a context for youth development,…
Advanced Biotelemetry Systems for Space Life Sciences: PH Telemetry
NASA Technical Reports Server (NTRS)
Hines, John W.; Somps, Chris; Ricks, Robert; Kim, Lynn; Connolly, John P. (Technical Monitor)
1995-01-01
The SENSORS 2000! (S2K!) program at NASA's Ames Research Center is currently developing a biotelemetry system for monitoring pH and temperature in unrestrained subjects. This activity is part of a broader scope effort to provide an Advanced Biotelemetry System (ABTS) for use in future space life sciences research. Many anticipated research endeavors will require biomedical and biochemical sensors and related instrumentation to make continuous inflight measurements in a variable-gravity environment. Since crew time is limited, automated data acquisition, data processing, data storage, and subject health monitoring are required. An automated biochemical and physiological data acquisition system based on non invasive or implantable biotelemetry technology will meet these requirements. The ABTS will ultimately acquire a variety of physiological measurands including temperature, biopotentials (e.g. ECG, EEG, EMG, EOG), blood pressure, flow and dimensions, as well as chemical and biological parameters including pH. Development activities are planned in evolutionary, leveraged steps. Near-term activities include 1) development of a dual channel pH/temperature telemetry system, and 2) development of a low bandwidth, 4-channel telemetry system, that measures temperature, heart rate, pressure, and pH. This abstract describes the pH/temperature telemeter.
Static calibration of the RSRA active-isolator rotor balance system
NASA Technical Reports Server (NTRS)
Acree, C. W., Jr.
1987-01-01
The Rotor Systems Research Aircraft (RSRA) active-isolator system is designed to reduce rotor vibrations transmitted to the airframe and to simultaneously measure all six forces and moments generated by the rotor. These loads are measured by using a combination of load cells, strain gages, and hydropneumatic active isolators with built-in pressure gages. The first static calibration of the complete active-isolator rotor balance system was performed in l983 to verify its load-measurement capabilities. Analysis of the data included the use of multiple linear regressions to determine calibration matrices for different data sets and a hysteresis-removal algorithm to estimate in-flight measurement errors. Results showed that the active-isolator system can fulfill most performance predictions. The results also suggested several possible improvements to the system.
Dong, Ruixia; Wang, Dongxu; Wang, Xiaoxiao; Zhang, Ke; Chen, Pingping; Yang, Chung S; Zhang, Jinsong
2016-12-01
Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea. Depending upon the dose and biological systems, EGCG may function either as an antioxidant or as an inducer of antioxidant defense via its pro-oxidant action or other unidentified mechanisms. By manipulating the selenium status, the present study investigated the interactions of EGCG with antioxidant defense systems including the thioredoxin system comprising of thioredoxin and thioredoxin reductase, the glutathione system comprising of glutathione and glutathione reductase coupled with glutaredoxin, and the Nrf2 system. In selenium-optimal mice, EGCG increased hepatic activities of thioredoxin reductase, glutathione reductase and glutaredoxin. These effects of EGCG appeared to be not due to overt pro-oxidant action because melatonin, a powerful antioxidant, did not influence the increase. However, in selenium-deficient mice, with low basal levels of thioredoxin reductase 1, the same dose of EGCG did not elevate the above-mentioned enzymes; intriguingly EGCG in turn activated hepatic Nrf2 response, leading to increased heme oxygenase 1 and NAD(P)H:quinone oxidoreductase 1 protein levels and thioredoxin activity. Overall, the present work reveals that EGCG is a robust inducer of the Nrf2 system only in selenium-deficient conditions. Under normal physiological conditions, in selenium-optimal mice, thioredoxin and glutathione systems serve as the first line defense systems against the stress induced by high doses of EGCG, sparing the activation of the Nrf2 system. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
Noachian Faulting: What Do Faults Tell Us About the Tectonic History of Tharsis?
NASA Technical Reports Server (NTRS)
Anderson, R. C.; Dohm, J. M.
2001-01-01
The western hemisphere of Mars is dominated by the formation of Tharsis, which is an enormous high-standing region (roughly 25% of the surface area of the planet) capped by volcanics, including the solar system's largest shield volcanoes. Tharsis is surrounded by an enormous radiating system of grabens and a circumferential system of wrinkle ridges that extends over the entire western hemisphere of Mars. This region is perhaps the largest and most long lived tectonic and volcanic province of any of the terrestrial planets with a well-preserved history of magmatic-driven activity that began in the Noachian and has lasted throughout Martian geologic time. Tharsis and the surrounding regions comprise numerous components, including volcanic constructs of varying sizes and extensive lava flow fields, large igneous plateaus, fault and ridge systems of varying extent and relative age of formation, gigantic outflow channel systems, vast system of canyons, and local and regional centers of tectonic activity. Many of these centers are interpreted to be the result of magmatic-related activity, including uplift, faulting, dike emplacement, volcanism, and local hydrothermal activity. Below we present a summary of our work for Tharsis focusing primarily on the earliest stage of development, the Noachian period. Here we hone in on the early centers and how they relate to the early development of the Tharsis Magmatic Complex (TMC).
A Survey of Active Vibration Isolation Systems for Microgravity Applications
NASA Technical Reports Server (NTRS)
Grodsinsky, Carlos M.; Whorton, Mark S.
2000-01-01
In view of the utility of space vehicles as orbiting science laboratories, the need for vibration isolation systems for acceleration sensitive experiments has gained increasing visibility. To date, three active microgravity vibration isolation systems have successfully been demonstrated in flight. This paper provides a tutorial discussion of the microgravity vibration isolation problem including a description of the acceleration environment of the International Space Station and attenuation requirements as well as a comparison of the dynamics of passive isolation, active rack-level isolation, and active payload-level isolation. This paper also surveys the flight test results of the three demonstrated systems: Suppression of Transient Accelerations By Levitation (STABLE); the Microgravity Vibration Isolation Mount (MIM); and the Active Rack Isolation System (ARIS).
NASA Goddard Space Flight Center
NASA Technical Reports Server (NTRS)
Carter, David; Wetzel, Scott
2000-01-01
The NASA SLR Operational Center is responsible for: 1) NASA SLR network control, sustaining engineering, and logistics; 2) ILRS mission operations; and 3) ILRS and NASA SLR data operations. NASA SLR network control and sustaining engineering tasks include technical support, daily system performance monitoring, system scheduling, operator training, station status reporting, system relocation, logistics and support of the ILRS Networks and Engineering Working Group. These activities ensure the NASA SLR systems are meeting ILRS and NASA mission support requirements. ILRS mission operations tasks include mission planning, mission analysis, mission coordination, development of mission support plans, and support of the ILRS Missions Working Group. These activities ensure than new mission and campaign requirements are coordinated with the ILRS. Global Normal Points (NP) data, NASA SLR FullRate (FR) data, and satellite predictions are managed as part of data operations. Part of this operation includes supporting the ILRS Data Formats and Procedures Working Group. Global NP data operations consist of receipt, format and data integrity verification, archiving and merging. This activity culminates in the daily electronic transmission of NP files to the CDDIS. Currently of all these functions are automated. However, to ensure the timely and accurate flow of data, regular monitoring and maintenance of the operational software systems, computer systems and computer networking are performed. Tracking statistics between the stations and the data centers are compared periodically to eliminate lost data. Future activities in this area include sub-daily (i.e., hourly) NP data management, more stringent data integrity tests, and automatic station notification of format and data integrity issues.
Production Systems. Laboratory Activities.
ERIC Educational Resources Information Center
Gallaway, Ann, Ed.
This production systems guide provides teachers with learning activities for secondary students. Introductory materials include an instructional planning outline and worksheet, an outline of essential elements, domains and objectives, a course description, and a content outline. The guide contains 30 modules on the following topics: production…
Communication Systems. Laboratory Activities.
ERIC Educational Resources Information Center
Sutherland, Barbara, Ed.
This communication systems guide provides teachers with learning activities for secondary students. Introductory materials include an instructional planning outline and worksheet, an outline of essential elements, a list of objectives, a course description, and a content outline. The guide contains 32 modules on the following topics: story…
Review of the windpower activities at the Brace Research Institute
NASA Technical Reports Server (NTRS)
Lawand, T. A.
1973-01-01
A chronology of windpower studies at the experimental station on Barbados is presented that includes the various development activities on wheeling windmills whose power output is utilized through electrical and electronic systems. A list of institute publications on windpower is included.
Solar heating system installed at Troy, Ohio
NASA Technical Reports Server (NTRS)
1980-01-01
The completed system was composed of three basic subsystems: the collector system consisting of 3,264 square feet of Owens Illinois evacuated glass tube collectors; the storage system which included a 5,000 gallon insulated steel tank; and the distribution and control system which included piping, pumping and heat transfer components as well as the solemoid activated valves and control logic for the efficient and safe operation of the entire system. This solar heating system was installed in an existing facility and was, therefore, a retrofit system. Extracts from the site files, specifications, drawings, installation, operation and maintenance instructions are included.
A Roadmap for using Agile Development in a Traditional System
NASA Technical Reports Server (NTRS)
Streiffert, Barbara; Starbird, Thomas
2006-01-01
I. Ensemble Development Group: a) Produces activity planning software for in spacecraft; b) Built on Eclipse Rich Client Platform (open source development and runtime software); c) Funded by multiple sources including the Mars Technology Program; d) Incorporated the use of Agile Development. II. Next Generation Uplink Planning System: a) Researches the Activity Planning and Sequencing Subsystem for Mars Science Laboratory (APSS); b) APSS includes Ensemble, Activity Modeling, Constraint Checking, Command Editing and Sequencing tools plus other uplink generation utilities; c) Funded by the Mars Technology Program; d) Integrates all of the tools for APSS.
A compact in vivo neutron activation analysis system to quantify manganese in human hand bone
NASA Astrophysics Data System (ADS)
Liu, Yingzi
As an urgent issue of correlating cumulative manganese (Mn) exposure to neurotoxicity, bone has emerged as an attractive biomarker for long-term Mn deposition and storage. A novel Deuterium-Deuterium (DD) neutron generator irradiation system has been simulated and constructed, incorporating moderator, reflector and shielding. This neutron activation analysis (NAA) irradiation assembly presents several desirable features, including high neutron flux, improved detection limit and acceptable neutron & photon dose, which would allow it be ready for clinical measurement. Key steps include simulation modeling and verifying, irradiation system design, detector characterization, and neutron flux and dose assessment. Activation foils were also analyzed to reveal the accurate neutron spectrum in the irradiation cave. The detection limit with this system is 0.428 ppm with 36 mSv equivalent hand dose and 52 microSv whole body effective dose.
Prototype solar heating and cooling systems, including potable hot water
NASA Technical Reports Server (NTRS)
Bloomquist, D.; Oonk, R. L.
1977-01-01
Progress made in the development, delivery, and support of two prototype solar heating and cooling systems including potable hot water is reported. The system consists of the following subsystems: collector, auxiliary heating, potable hot water, storage, control, transport, and government-furnished site data acquisition. A comparison of the proposed Solaron Heat Pump and Solar Desiccant Heating and Cooling Systems, installation drawings, data on the Akron House at Akron, Ohio, and other program activities are included.
Microwave systems analysis, solar power satellite. [alignment of the antenna array
NASA Technical Reports Server (NTRS)
1979-01-01
Various alternative active approaches to achieving aand maintaining flatness for the microwave power transmission system (MPTS) were studied. A baseline active alignment scheme was developed which includes subarray attachment mechanisms, height and tilting adjustments, service corridors, a rotating laser beam reference system, monopulse pointing techniques, and the design of a beam-centering photoconductive sensor.
Active imaging system with Faraday filter
Snyder, James J.
1993-01-01
An active imaging system has a low to medium powered laser transmitter and receiver wherein the receiver includes a Faraday filter with an ultranarrow optical bandpass and a bare (nonintensified) CCD camera. The laser is locked in the vicinity of the passband of the Faraday filter. The system has high sensitivity to the laser illumination while eliminating solar background.
Active imaging system with Faraday filter
Snyder, J.J.
1993-04-13
An active imaging system has a low to medium powered laser transmitter and receiver wherein the receiver includes a Faraday filter with an ultranarrow optical bandpass and a bare (nonintensified) CCD camera. The laser is locked in the vicinity of the passband of the Faraday filter. The system has high sensitivity to the laser illumination while eliminating solar background.
NASA Technical Reports Server (NTRS)
Connolly, Janis H.; Arch, M.; Elfezouaty, Eileen Schultz; Novak, Jennifer Blume; Bond, Robert L. (Technical Monitor)
1999-01-01
Design and Human Engineering (HE) processes strive to ensure that the human-machine interface is designed for optimal performance throughout the system life cycle. Each component can be tested and assessed independently to assure optimal performance, but it is not until full integration that the system and the inherent interactions between the system components can be assessed as a whole. HE processes (which are defining/app lying requirements for human interaction with missions/systems) are included in space flight activities, but also need to be included in ground activities and specifically, ground facility testbeds such as Bio-Plex. A unique aspect of the Bio-Plex Facility is the integral issue of Habitability which includes qualities of the environment that allow humans to work and live. HE is a process by which Habitability and system performance can be assessed.
DR5 as a reporter system to study auxin response in Populus.
Chen, Yiru; Yordanov, Yordan S; Ma, Cathleen; Strauss, Steven; Busov, Victor B
2013-03-01
KEY MESSAGE : Auxin responsive promoter DR5 reporter system is functional in Populus to monitor auxin response in tissues including leaves, roots, and stems. We described the behavior of the DR5::GUS reporter system in stably transformed Populus plants. We found several similarities with Arabidopsis, including sensitivity to native and synthetic auxins, rapid induction after treatment in a variety of tissues, and maximal responses in root tissues. There were also several important differences from Arabidopsis, including slower time to maximum response and lower induction amplitude. Young leaves and stem sections below the apex showed much higher DR5 activity than did older leaves and stems undergoing secondary growth. DR5 activity was highest in cortex, suggesting high levels of auxin concentration and/or sensitivity in this tissue. Our study shows that the DR5 reporter system is a sensitive and facile system for monitoring auxin responses and distribution at cellular resolution in poplar.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Franta, G.; Baylin, F.; Crowther, R.
1981-06-01
This Solar Design Workbook presents solar building design applications for commercial buildir^s. The book is divided into four sections. The first section describes the variety of solar applications in buildings including conservation aspects, solar fundamentals, passive systems, active systems, daylighting, and other solar options. Solar system design evaluation techniques including considerations for building energy requirements, passive systems, active systems, and economics are presented in Section II. The third section attempts to assist the designer in the building design process for energy conservation and solar applications including options and considerations for pre-design, design, and post-design phases. The information required for themore » solar design proee^ has not been fully developed at this time. Therefore, Section III is incomplete, but an overview of the considerations with some of the design proces elements is presented. Section IV illustrates ease studies that utilize solar applications in the building design.« less
Systems and methods for reconfiguring input devices
NASA Technical Reports Server (NTRS)
Lancaster, Jeff (Inventor); De Mers, Robert E. (Inventor)
2012-01-01
A system includes an input device having first and second input members configured to be activated by a user. The input device is configured to generate activation signals associated with activation of the first and second input members, and each of the first and second input members are associated with an input function. A processor is coupled to the input device and configured to receive the activation signals. A memory coupled to the processor, and includes a reconfiguration module configured to store the input functions assigned to the first and second input members and, upon execution of the processor, to reconfigure the input functions assigned to the input members when the first input member is inoperable.
ERIC Educational Resources Information Center
White, Peter J. T.; Delaney, David G.; Syncox, David; Akerberg, Oscar Avila; Alters, Brian
2011-01-01
Student response systems can help instructors integrate active learning into their classrooms. Such technology is known by a variety of names, including classroom response systems, student response systems, audience response systems, electronic response systems, personal response systems, zappers, and clickers. The "system" consists of three…
Donoso Brown, Elena V; McCoy, Sarah Westcott; Fechko, Amber S; Price, Robert; Gilbertson, Torey; Moritz, Chet T
2014-08-01
To investigate the preliminary effectiveness of surface electromyography (sEMG) biofeedback delivered via interaction with a commercial computer game to improve motor control in chronic stroke survivors. Single-blinded, 1-group, repeated-measures design: A1, A2, B, A3 (A, assessment; B, intervention). Laboratory and participants' homes. A convenience sample of persons (N=9) between 40 and 75 years of age with moderate to severe upper extremity motor impairment and at least 6 months poststroke completed the study. The electromyography-controlled video game system targeted the wrist muscle activation with the goal of increasing selective muscle activation. Participants received several laboratory training sessions with the system and then were instructed to use the system at home for 45 minutes, 5 times per week for the following 4 weeks. Primary outcome measures included duration of system use, sEMG during home play, and pre/post sEMG measures during active wrist motion. Secondary outcomes included kinematic analysis of movement and functional outcomes, including the Wolf Motor Function Test and the Chedoke Arm and Hand Activity Inventory-9. One third of participants completed or exceeded the recommended amount of system use. Statistically significant changes were observed on both game play and pre/post sEMG outcomes. Limited carryover, however, was observed on kinematic or functional outcomes. This preliminary investigation indicates that use of the electromyography-controlled video game impacts muscle activation. Limited changes in kinematic and activity level outcomes, however, suggest that the intervention may benefit from the inclusion of a functional activity component. Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
Network support for system initiated checkpoints
Chen, Dong; Heidelberger, Philip
2013-01-29
A system, method and computer program product for supporting system initiated checkpoints in parallel computing systems. The system and method generates selective control signals to perform checkpointing of system related data in presence of messaging activity associated with a user application running at the node. The checkpointing is initiated by the system such that checkpoint data of a plurality of network nodes may be obtained even in the presence of user applications running on highly parallel computers that include ongoing user messaging activity.
Principles and core functions of integrated child health information systems.
Hinman, Alan R; Atkinson, Delton; Diehn, Tonya Norvell; Eichwald, John; Heberer, Jennifer; Hoyle, Therese; King, Pam; Kossack, Robert E; Williams, Donna C; Zimmerman, Amy
2004-11-01
Infants undergo a series of preventive and therapeutic health interventions and activities. Typically, each activity includes collection and submission of data to a dedicated information system. Subsequently, health care providers, families, and health programs must query each information system to determine the child's status in a given area. Efforts are underway to integrate information in these separate information systems. This requires specifying the core functions that integrated information systems must perform.
Formative assessment in physiology teaching using a wireless classroom communication system.
Paschal, Cynthia B
2002-12-01
Systems physiology, studied by biomedical engineers, is an analytical way to approach the homeostatic foundations of basic physiology. In many systems physiology courses, students attend lectures and are given homework and reading assignments to complete outside of class. The effectiveness of this traditional approach was compared with an approach in which a wireless classroom communication system was used to provide instant feedback on in-class learning activities and reading assignment quizzes. Homework was eliminated in this approach. The feedback system used stimulated 100% participation in class and facilitated rapid formative assessment. The results of this study indicate that learning of systems physiology concepts including physiology is at least, as if not more, effective when in-class quizzes and activities with instant feedback are used in place of traditional learning activities including homework. When results of this study are interpreted in light of possible effects of the September 11, 2001 terrorist attacks on student learning in the test group, it appears that the modified instruction may be more effective than the traditional instruction.
Linking Complexity with Cultural Historical Activity Theory
ERIC Educational Resources Information Center
McMurtry, Angus
2006-01-01
This paper explores the similarities and differences between complexity science's and cultural-historical activity theory's understandings of human learning. Notable similarities include their emphasis on the importance of social systems or collectives in understanding human knowledge and practices, as well as their characterization of systems'…
ERIC Educational Resources Information Center
McDonald's Corp., Oak Brook, IL.
One of five McDonald's Action Packs, this learning package introduces intermediate grade students to basic economic concepts. The fourteen activities include the topics of consumption (4 activities), production (5), the market system (3), a pretest, and a posttest. Specific titles under consumption include The Wonderful Treasure Tree (introduction…
Prototype solar heating and cooling systems
NASA Technical Reports Server (NTRS)
1978-01-01
Eight prototype systems were developed. The systems are 3, 25, and 75-ton size units. The manufacture, test, installation, maintenance, problem resolution, and performance evaluation of the systems is described. Size activities for the various systems are included.
Computational Structures Technology for Airframes and Propulsion Systems
NASA Technical Reports Server (NTRS)
Noor, Ahmed K. (Compiler); Housner, Jerrold M. (Compiler); Starnes, James H., Jr. (Compiler); Hopkins, Dale A. (Compiler); Chamis, Christos C. (Compiler)
1992-01-01
This conference publication contains the presentations and discussions from the joint University of Virginia (UVA)/NASA Workshops. The presentations included NASA Headquarters perspectives on High Speed Civil Transport (HSCT), goals and objectives of the UVA Center for Computational Structures Technology (CST), NASA and Air Force CST activities, CST activities for airframes and propulsion systems in industry, and CST activities at Sandia National Laboratory.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Dmitriev, Alexander S.; Yemelyanov, Ruslan Yu.; Moscow Institute of Physics and Technology
The paper deals with a new multi-element processor platform assigned for modelling the behaviour of interacting dynamical systems, i.e., active wireless network. Experimentally, this ensemble is implemented in an active network, the active nodes of which include direct chaotic transceivers and special actuator boards containing microcontrollers for modelling the dynamical systems and an information display unit (colored LEDs). The modelling technique and experimental results are described and analyzed.
NASA Technical Reports Server (NTRS)
Badler, N. I.
1985-01-01
Human motion analysis is the task of converting actual human movements into computer readable data. Such movement information may be obtained though active or passive sensing methods. Active methods include physical measuring devices such as goniometers on joints of the body, force plates, and manually operated sensors such as a Cybex dynamometer. Passive sensing de-couples the position measuring device from actual human contact. Passive sensors include Selspot scanning systems (since there is no mechanical connection between the subject's attached LEDs and the infrared sensing cameras), sonic (spark-based) three-dimensional digitizers, Polhemus six-dimensional tracking systems, and image processing systems based on multiple views and photogrammetric calculations.
[Biotechnology's macroeconomic impact].
Dones Tacero, Milagros; Pérez García, Julián; San Román, Antonio Pulido
2008-12-01
This paper tries to yield an economic valuation of biotechnological activities in terms of aggregated production and employment. This valuation goes beyond direct estimation and includes the indirect effects derived from sectorial linkages between biotechnological activities and the rest of economic system. To deal with the proposed target several sources of data have been used, including official data from National Statistical Office (INE) such us national accounts, input-output tables, and innovation surveys, as well as, firms' level balance sheets and income statements and also specific information about research projects compiled by Genoma Spain Foundation. Methodological approach is based on the estimation of a new input-output table which includes the biotechnological activities as a specific branch. This table offers both the direct impact of these activities and the main parameters to obtain the induced effects over the rest of the economic system. According to the most updated available figures, biotechnological activities would have directly generated almost 1,600 millions of euros in 2005, and they would be employed more than 9,000 workers. But if we take into account the full linkages with the rest of the system, the macroeconomic impact of Biotechnological activities would reach around 5,000 millions euros in production terms (0.6% of total GDP) and would be responsible, directly or indirectly, of more than 44,000 employments.
NASA Technical Reports Server (NTRS)
Ryan, John J.; Bosworth, John T.; Burken, John J.; Suh, Peter M.
2014-01-01
The X-56 Multi-Utility Technology Testbed aircraft system is a versatile experimental research flight platform. The system was primarily designed to investigate active control of lightweight flexible structures, but is reconfigurable and capable of hosting a wide breadth of research. Current research includes flight experimentation of a Lockheed Martin designed active control flutter suppression system. Future research plans continue experimentation with alternative control systems, explore the use of novel sensor systems, and experiments with the use of novel control effectors. This paper describes the aircraft system, current research efforts designed around the system, and future planned research efforts that will be hosted on the aircraft system.
Hybrid Damping System for an Electronic Equipment Mounting Shelf
NASA Technical Reports Server (NTRS)
Voracek, David; Kolkailah, Faysal A.; Cavalli, J. R.; Elghandour, Eltahry
1997-01-01
The objective of this study was to design and construct a vibration control system for an electronic equipment shelf to be evaluated in the NASA Dryden FTF-II. The vibration control system was a hybrid system which included passive and active damping techniques. Passive damping was fabricated into the equipment shelf using ScothDamp(trademark) damping film and aluminum constraining layers. Active damping was achieved using a two channel active control circuit employing QuickPack(trademark) sensors and actuators. Preliminary Chirp test results indicated passive damping smoothed the frequency response while active damping reduced amplitudes of the frequency response for most frequencies below 500Hz.
Hybrid Damping System for an Electronic Equipment Mounting Shelf
NASA Technical Reports Server (NTRS)
Voracek, David; Kolkailah, Faysal A.; Cavalli, J. R.; Elghandour, Eltahry
1997-01-01
The objective of this study was to design and construct a vibration control system for an electronic equipment shelf to be evaluated in the NASA Dryden FTF-11. The vibration control system was a hybrid system which included passive and active damping techniques. Passive damping was fabricated into the equipment shelf using ScothDamp(trademark) damping film and aluminum constraining layers. Active damping was achieved using a two channel active control circuit employing QuickPack(trademark) sensors and actuators. Preliminary Chirp test results indicated passive damping smoothed the frequency response while active damping reduced amplitudes of the frequency response for most frequencies below 500Hz.
Hydrogen Fire in a Storage Vessel
NASA Technical Reports Server (NTRS)
Hester, Zena M.
2010-01-01
On October 23, 2007, the operations team began a procedure to sample the Liquid Hydrogen (LH2) storage vessels ("tanks"), and associated transfer system. This procedure was being performed to determine the conditions within the system, and if necessary, to purge the system of any excess Gaseous Hydrogen (GH2) in preparation for reactivation of the system. The system had not been used since 2003. The LH2 storage system contains two (2) spherical pressure vessels of 225,000 gallons in volume, with a maximum working pressure (MAWP) of 50 psig. Eight inch transfer piping connects them to the usage point. Operations began with activation of the burnstack for the LH2 storage area. Pneumatic (GN2) systems in the storage area were then activated and checked. Pressurization of storage tank number 1 with gaseous nitrogen (GN2) was initiated, with a target pressure of 10 psig, at which point samples were planned to be taken. At 5 psig, a loud noise was heard in the upper area of tank number 2. Smoke was seen exiting the burnstack and from the insulation on vent lines for both tanks. At this time tank number 1 was vented and the pressurization system was secured. The mishap resulted in physical damage to both storage tanks, as well as to some of the piping for both tanks. Corrective action included repair of the damaged hardware by a qualified contractor. Preventive action included documented organizational policy and procedures for establishing standby and mothball conditions for facilities and equipment, including provisions as detailed in the investigation report recommendations: Recommendation 1: The using organization should define necessary activities in order to place hydrogen systems in long term periods of inactivity. The defined activities should address requirements for rendering inert, isolation (i.e., physical disconnect, double block and bleed, etc.) and periodic monitoring. Recommendation 2: The using organization should develop a process to periodically monitor hazardous systems for proper configuration (i.e., a daily/weekly/monthly check sheet to verify critical purges are active).
System architectures for telerobotic research
NASA Technical Reports Server (NTRS)
Harrison, F. Wallace
1989-01-01
Several activities are performed related to the definition and creation of telerobotic systems. The effort and investment required to create architectures for these complex systems can be enormous; however, the magnitude of process can be reduced if structured design techniques are applied. A number of informal methodologies supporting certain aspects of the design process are available. More recently, prototypes of integrated tools supporting all phases of system design from requirements analysis to code generation and hardware layout have begun to appear. Activities related to system architecture of telerobots are described, including current activities which are designed to provide a methodology for the comparison and quantitative analysis of alternative system architectures.
Radiation protection for manned space activities
NASA Technical Reports Server (NTRS)
Jordan, T. M.
1983-01-01
The Earth's natural radiation environment poses a hazard to manned space activities directly through biological effects and indirectly through effects on materials and electronics. The following standard practices are indicated that address: (1) environment models for all radiation species including uncertainties and temporal variations; (2) upper bound and nominal quality factors for biological radiation effects that include dose, dose rate, critical organ, and linear energy transfer variations; (3) particle transport and shielding methodology including system and man modeling and uncertainty analysis; (4) mission planning that includes active dosimetry, minimizes exposure during extravehicular activities, subjects every mission to a radiation review, and specifies operational procedures for forecasting, recognizing, and dealing with large solar flaes.
EPA MOBILE INCINERATION SYSTEM MODIFICATIONS, TESTING AND OPERATIONS - FEBRUARY 1986 TO JUNE 1989
The report covers the field demonstration activities of the U.S. Environmental Protection Agency's Mobile Incineration System (MIS) from February 1986 to June 1989 at the Denney Farm Site, Missouri. The activities discussed in the current report include: modifications made to the...
Moodog: Tracking Student Activity in Online Course Management Systems
ERIC Educational Resources Information Center
Zhang, Hangjin; Almeroth, Kevin
2010-01-01
Many universities are currently using Course Management Systems (CMSes) to conduct online learning, for example, by distributing course materials or submitting homework assignments. However, most CMSes do not include comprehensive activity tracking and analysis capabilities. This paper describes a method to track students' online learning…
Elements of active vibration control for rotating machinery
NASA Technical Reports Server (NTRS)
Ulbrich, Heinz
1990-01-01
The success or failure of active vibration control is determined by the availability of suitable actuators, modeling of the entire system including all active elements, positioning of the actuators and sensors, and implementation of problem-adapted control concepts. All of these topics are outlined and their special problems are discussed in detail. Special attention is given to efficient modeling of systems, especially for considering the active elements. Finally, design methods for and the application of active vibration control on rotating machinery are demonstrated by several real applications.
Active-Twist Rotor Control Applications for UAVs
NASA Technical Reports Server (NTRS)
Wilbur, Matthew L.; Wilkie, W. Keats
2004-01-01
The current state-of-the-art in active-twist rotor control is discussed using representative examples from analytical and experimental studies, and the application to rotary-wing UAVs is considered. Topics include vibration and noise reduction, rotor performance improvement, active blade tracking, stability augmentation, and rotor blade de-icing. A review of the current status of piezoelectric fiber composite actuator technology, the class of piezoelectric actuators implemented in active-twist rotor systems, is included.
Design of a vibration isolation system for a cycle ergometer to be used onboard the Space Shuttle
NASA Technical Reports Server (NTRS)
Pearson, Lillian; Tait, Steven; Trevino, Maurice
1991-01-01
Low frequency vibrations generated during exercise using the cycle ergometer onboard the Space Shuttle are disrupting sensitive microgravity experiments. The design team is asked by NASA/USRA to generate alternatives for the design of a vibration isolation system for the cycle ergometer. It is the design team's objective to present alternative designs and a problem solution for a vibration isolation system for an exercise cycle ergometer to be used onboard the Space Shuttle. In the development of alternative designs, the design team emphasizes passive systems as opposed to active control systems. This decision is made because the team feels that passive systems are less complex than active control systems, external energy sources are not required, and mass is reduced due to the lack of machinery such as servomotors or compressors typical of active control systems. Eleven alternative designs are developed by the design team. From these alternatives, three active control systems are included to compare the benefits of active and passive systems. Also included in the alternatives is an isolation system designed by an independent engineer that was acquired late in the project. The eight alternatives using passive isolation systems are narrowed down by selection criteria to four considered to be the most promising by the design team. A feasibility analysis is performed on these four passive isolation systems. Based on the feasibility analysis, a final design solution is chosen and further developed. From the development of the design, the design team has concluded that passive systems are not effective at isolating vibrations for the low frequencies considered for this project. Recommendations are made for guidelines of passive isolation design and application of such systems.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fischer, J.
2001-07-09
This report summarizes an investigation of the performance of two active desiccant cooling systems that were installed as pilot systems in two locations--a college dormitory and a research laboratory--during the fall of 1999. The laboratory system was assembled in the field from commercially available Trane air-handling modules combined with a standard total energy recovery module and a customized active desiccant wheel, both produced by SEMCO. The dormitory system was a factory-built, integrated system produced by SEMCO that included both active desiccant and sensible-only recovery wheels, a direct-fired gas regeneration section, and a pre-piped Trane heat pump condensing section. Both systemsmore » were equipped with direct digital control systems, complete with full instrumentation and remote monitoring capabilities. This report includes detailed descriptions of these two systems, installation details, samples of actual performance, and estimations of the energy savings realized. These pilot sites represent a continuation of previous active desiccant product development research (Fischer, Hallstrom, and Sand 2000; Fischer 2000). Both systems performed as anticipated, were reliable, and required minimal maintenance. The dehumidification/total-energy-recovery hybrid approach was particularly effective in all respects. System performance showed remarkable improvement in latent load handling capability and operating efficiency compared with the original conventional cooling system and with the conventional system that remained in another, identical wing of the facility. The dehumidification capacity of the pilot systems was very high, the cost of operation was very low, and the system was cost-effective, offering a simple payback for these retrofit installations of approximately 5 to 6 years. Most important, the dormitory system resolved numerous indoor air quality problems in the dormitory by providing effective humidity control and increased, continuous ventilation air.« less
System Study at SUNY College Bookstore/Oswego
ERIC Educational Resources Information Center
DeVita, Richard; And Others
1975-01-01
A system study of the textbook ordering department is presented including systems flow chart, chart of activities, and description of operations and procedures for utilizing the computer system. Changes based on the study are noted. (JT)
Applications of active adaptive noise control to jet engines
NASA Technical Reports Server (NTRS)
Shoureshi, Rahmat; Brackney, Larry
1993-01-01
During phase 2 research on the application of active noise control to jet engines, the development of multiple-input/multiple-output (MIMO) active adaptive noise control algorithms and acoustic/controls models for turbofan engines were considered. Specific goals for this research phase included: (1) implementation of a MIMO adaptive minimum variance active noise controller; and (2) turbofan engine model development. A minimum variance control law for adaptive active noise control has been developed, simulated, and implemented for single-input/single-output (SISO) systems. Since acoustic systems tend to be distributed, multiple sensors, and actuators are more appropriate. As such, the SISO minimum variance controller was extended to the MIMO case. Simulation and experimental results are presented. A state-space model of a simplified gas turbine engine is developed using the bond graph technique. The model retains important system behavior, yet is of low enough order to be useful for controller design. Expansion of the model to include multiple stages and spools is also discussed.
Resveratrol as a potential therapeutic drug for respiratory system diseases.
Zhu, Xiao-Dan; Lei, Xiao-Ping; Dong, Wen-Bin
2017-01-01
Respiratory system diseases are common and major ailments that seriously endanger human health. Resveratrol, a polyphenolic phytoalexin, is considered an anti-inflammatory, antioxidant, and anticancer agent. Thanks to its wide range of biological activities, resveratrol has become a hotspot in many fields, including respiratory system diseases. Indeed, research has demonstrated that resveratrol is helpful to relieve pulmonary function in the general population. Meanwhile, growing evidence indicates that resveratrol plays a protective role in respiratory system diseases. This review aimed to summarize the main protective effects of resveratrol in respiratory system diseases, including its anti-inflammatory, antiapoptotic, antioxidant, antifibrotic, antihypertensive, and anticancer activities. We found that resveratrol plays a protective role in the respiratory system through a variety of mechanisms, and so it may become a new drug for the treatment of respiratory system diseases.
Xiong, Weiyi; Lv, Jun; Li, Liming
2010-11-17
In recent years, problems like insufficient coordination, low efficiency, and heavy working load in national communicable disease surveillance systems in China have been pointed out by many researchers. To strengthen the national communicable disease surveillance systems becomes an immediate concern. Since the World Health Organization has recommended that a structured approach to strengthen national communicable disease surveillance must include an evaluation to existing systems which usually begins with a systematic description, we conducted the first survey for communicable disease surveillance systems in China, in order to understand the situation of core and support surveillance activities at province-level and county-level centers for disease control and prevention (CDCs). A nationwide survey was conducted by mail between May and October 2006 to investigate the implementation of core and support activities of the Notifiable Disease Reporting System (NDRS) and disease-specific surveillance systems in all of the 31 province-level and selected 14 county-level CDCs in Mainland China The comments on the performance of communicable disease surveillance systems were also collected from the directors of CDCs in this survey. The core activities of NDRS such as confirmation, reporting and analysis and some support activities such as supervision and staff training were found sufficient in both province-level and county-level surveyed CDCs, but other support activities including information feedback, equipment and financial support need to be strengthened in most of the investigated CDCs. A total of 47 communicable diseases or syndromes were under surveillance at province level, and 20 diseases or syndromes at county level. The activities among different disease-specific surveillance systems varied widely. Acute flaccid paralysis (AFP), measles and tuberculosis (TB) surveillance systems got relatively high recognition both at province level and county level. China has already established a national communicable disease surveillance framework that combines NDRS and disease-specific surveillance systems. The core and support activities of NDRS were found sufficient, while the implementation of those activities varied among different disease-specific surveillance systems.
Methods and Systems for Configuring Sensor Acquisition Based on Pressure Steps
NASA Technical Reports Server (NTRS)
DeDonato, Mathew (Inventor)
2015-01-01
Technologies are provided for underwater measurements. A system includes an underwater vessels including: a plurality of sensors disposed thereon for measuring underwater properties; and a programmable controller configured to selectively activate the plurality of sensors based at least in part on underwater pressure. A user may program at what pressure ranges certain sensors are activated to measure selected properties, and may also program the ascent/descent rate of the underwater vessel, which is correlated with the underwater pressure.
ERIC Educational Resources Information Center
Fite, Ronald S.
This report details the research activities conducted by Del Mar College, as a subcontractor of Project FOLLOW-UP, in the design, development, and implementation of a graduate follow-up system. The activities included questionnaire design, development of manual and computerized record-keeping systems, student-graduate identification, and…
Calibration of the Total and Static Pressure Transducers in the DSTO Transonic Wind Tunnel
2010-08-01
handled by the ActiveX control MSCOMM32.OCX which is not part of the Microsoft Windows operating system. It is, however, included as part of the...implemented new measures to register ActiveX controls in its Windows suite of operating systems, which has made the above file obsolete and it could no...longer be used if the Windows operating system were updated. If this is the case, then the new version of ActiveX control files can be installed using
Conservation and solar energy program: congressional budget request, FY 1982
DOE Office of Scientific and Technical Information (OSTI.GOV)
None
1981-01-01
Funding summaries are presented for the Conservation and Solar Energy Program funding information and program overview on energy conservation (Volume 7 of 7, DOE/CR-0011/2) are included for the Buildings and Community Systems, Industrial, Transportation; State and Local, Multi-Sector, Energy Impact Assistance, and Residential/Commercial retrofit programs. Funding information and program overviews on solar technology (Volume 2 of 7, DOE/CR-011/2) are included for Active and Passive Solar Heating and Cooling, Photovoltaics Energy Systems, Solar Thermal Power Systems, Biomass Energy Systems, Wind Energy Conversion Systems, Ocean Systems, Solar International Activities, Solar Information Systems, SERI Facility, MX-RES, Program Direction, and Alcohol Fuels programs. Informationmore » and overviews on energy production, demonstration, and distribution (Volume 6 of 7, DOE/CR-0011/2) are given for the solar program. A funding summary and a program overview are included for electrochemical and physical and chemical storage systems as appearing in DOE/CR-0011/2, Volume 3 of 7. Relevant tabulated data from the FY 1981. Request to the Congress are presented for Supplementals, Rescissions, and Deferrals. (MCW)« less
Solar Parabolic Dish Annual Technology Evaluation Report
NASA Technical Reports Server (NTRS)
1983-01-01
The activities of the JPL Solar Thermal Power Systems Parabolic Dish Project for FY 1982 are summarized. Included are discussions on designs of module development including their concentrator, receiver, and power conversion subsystems. Analyses and test results, along with progress on field tests, Small Community Experiment System development, and tests at the Parabolic Dish Test Site are also included.
40 CFR 63.10020 - How do I monitor and collect data to demonstrate continuous compliance?
Code of Federal Regulations, 2014 CFR
2014-07-01
...-of-control periods, or required monitoring system quality assurance or control activities in... monitoring system quality assurance or quality control activities including, as applicable, calibration... collect data according to this section and the site-specific monitoring plan required by § 63.10000(d). (b...
40 CFR 63.11221 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2013 CFR
2013-07-01
...-control periods, and required monitoring system quality assurance or quality control activities including... monitoring system quality assurance or quality control activities in calculations used to report emissions or... monitoring data I must obtain? 63.11221 Section 63.11221 Protection of Environment ENVIRONMENTAL PROTECTION...
40 CFR 63.11221 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2014 CFR
2014-07-01
...-control periods, and required monitoring system quality assurance or quality control activities including... monitoring system quality assurance or quality control activities in calculations used to report emissions or... monitoring data I must obtain? 63.11221 Section 63.11221 Protection of Environment ENVIRONMENTAL PROTECTION...
40 CFR 63.10020 - How do I monitor and collect data to demonstrate continuous compliance?
Code of Federal Regulations, 2012 CFR
2012-07-01
...-of-control periods, or required monitoring system quality assurance or control activities in... monitoring system quality assurance or quality control activities including, as applicable, calibration... collect data according to this section and the site-specific monitoring plan required by § 63.10000(d). (b...
40 CFR 63.10020 - How do I monitor and collect data to demonstrate continuous compliance?
Code of Federal Regulations, 2013 CFR
2013-07-01
...-of-control periods, or required monitoring system quality assurance or control activities in... monitoring system quality assurance or quality control activities including, as applicable, calibration... collect data according to this section and the site-specific monitoring plan required by § 63.10000(d). (b...
Restriction/modification polypeptides, polynucleotides, and methods
Westpheling, Janet; Chung, DaeHwan; Huddleston, Jennifer; Farkas, Joel A
2015-02-24
The present invention relates to the discovery of a novel restriction/modification system in Caldicellulosiruptor bescii. The discovered restriction enzyme is a HaeIII-like restriction enzyme that possesses a thermophilic activity profile. The restriction/modification system also includes a methyltransferase, M.CbeI, that methylates at least one cytosine residue in the CbeI recognition sequence to m.sup.4C. Thus, the invention provides, in various aspects, isolated CbeI or M.CbeI polypeptides, or biologically active fragments thereof; isolated polynucleotides that encode the CbeI or M.CbeI polypeptides or biologically active fragments thereof, including expression vectors that include such polynucleotide sequences; methods of digesting DNA using a CbeI polypeptide; methods of treating a DNA molecule using a M.CbeI polypeptide; and methods of transforming a Caldicellulosiruptor cell.
30 CFR 285.810 - What must I include in my Safety Management System?
Code of Federal Regulations, 2011 CFR
2011-07-01
... Activities Conducted Under SAPs, COPs and GAPs Safety Management Systems § 285.810 What must I include in my... your COP (provided under § 285.627(d)) and, when required by this part, your SAP (as provided in § 285...
Six degree of freedom active vibration damping for space application
NASA Technical Reports Server (NTRS)
Haynes, Leonard S.
1993-01-01
Work performed during the period 1 Jan. - 31 Mar. 1993 on six degree of freedom active vibration damping for space application is presented. A performance and cost report is included. Topics covered include: actuator testing; mechanical amplifier design; and neural network control system development and experimental evaluation.
Expert systems for MSFC power systems
NASA Technical Reports Server (NTRS)
Weeks, David J.
1988-01-01
Future space vehicles and platforms including Space Station will possess complex power systems. These systems will require a high level of autonomous operation to allow the crew to concentrate on mission activities and to limit the number of ground support personnel to a reasonable number. The Electrical Power Branch at NASA-Marshall is developing advanced automation approaches which will enable the necessary levels of autonomy. These approaches include the utilization of knowledge based or expert systems.
A Role for the Motor System in Binding Abstract Emotional Meaning
Carota, Francesca; Hauk, Olaf; Mohr, Bettina; Pulvermüller, Friedemann
2012-01-01
Sensorimotor areas activate to action- and object-related words, but their role in abstract meaning processing is still debated. Abstract emotion words denoting body internal states are a critical test case because they lack referential links to objects. If actions expressing emotion are crucial for learning correspondences between word forms and emotions, emotion word–evoked activity should emerge in motor brain systems controlling the face and arms, which typically express emotions. To test this hypothesis, we recruited 18 native speakers and used event-related functional magnetic resonance imaging to compare brain activation evoked by abstract emotion words to that by face- and arm-related action words. In addition to limbic regions, emotion words indeed sparked precentral cortex, including body-part–specific areas activated somatotopically by face words or arm words. Control items, including hash mark strings and animal words, failed to activate precentral areas. We conclude that, similar to their role in action word processing, activation of frontocentral motor systems in the dorsal stream reflects the semantic binding of sign and meaning of abstract words denoting emotions and possibly other body internal states. PMID:21914634
The quartet theory of human emotions: An integrative and neurofunctional model
NASA Astrophysics Data System (ADS)
Koelsch, Stefan; Jacobs, Arthur M.; Menninghaus, Winfried; Liebal, Katja; Klann-Delius, Gisela; von Scheve, Christian; Gebauer, Gunter
2015-06-01
Despite an explosion of research in the affective sciences during the last few decades, interdisciplinary theories of human emotions are lacking. Here we present a neurobiological theory of emotions that includes emotions which are uniquely human (such as complex moral emotions), considers the role of language for emotions, advances the understanding of neural correlates of attachment-related emotions, and integrates emotion theories from different disciplines. We propose that four classes of emotions originate from four neuroanatomically distinct cerebral systems. These emotional core systems constitute a quartet of affect systems: the brainstem-, diencephalon-, hippocampus-, and orbitofrontal-centred affect systems. The affect systems were increasingly differentiated during the course of evolution, and each of these systems generates a specific class of affects (e.g., ascending activation, pain/pleasure, attachment-related affects, and moral affects). The affect systems interact with each other, and activity of the affect systems has effects on - and interacts with - biological systems denoted here as emotional effector systems. These effector systems include motor systems (which produce actions, action tendencies, and motoric expression of emotion), peripheral physiological arousal, as well as attentional and memory systems. Activity of affect systems and effector systems is synthesized into an emotion percept (pre-verbal subjective feeling), which can be transformed (or reconfigured) into a symbolic code such as language. Moreover, conscious cognitive appraisal (involving rational thought, logic, and usually language) can regulate, modulate, and partly initiate, activity of affect systems and effector systems. Our emotion theory integrates psychological, neurobiological, sociological, anthropological, and psycholinguistic perspectives on emotions in an interdisciplinary manner, aiming to advance the understanding of human emotions and their neural correlates.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sharp, M. Keith; Barnett, Russell
The objective of this project is to promote awareness and knowledge of active solar energy technologies by installing and monitoring the following demonstration systems in Kentucky: 1) Pool heating system, Churchill Park School, 2) Water heating and daylighting systems, Middletown and Aiken Road Elementary Schools, 3) Photovoltaic street light comparison, Louisville Metro, 4) up to 25 domestic water heating systems across Kentucky. These tasks will be supported by outreach activities, including a solar energy installer training workshop and a Kentucky Solar Energy Conference.
Flutter suppression by active control and its benefits
NASA Technical Reports Server (NTRS)
Doggett, R. V., Jr.; Townsend, J. C.
1976-01-01
A general discussion of the airplane applications of active flutter suppression systems is presented with focus on supersonic cruise aircraft configurations. Topics addressed include a brief historical review; benefits, risks, and concerns; methods of application; and applicable configurations. Results are presented where the direct operating costs and performance benefits of an arrow wing supersonic cruise vehicle equipped with an active flutter suppression system are compared with corresponding costs and performance of the same baseline airplane where the flutter deficiency was corrected by passive methods (increases in structural stiffness). The design, synthesis, and conceptual mechanization of the active flutter suppression system are discussed. The results show that a substantial weight savings can be accomplished by using the active system. For the same payload and range, airplane direct operating costs are reduced by using the active system. The results also indicate that the weight savings translates into increased range or payload.
Digital active material processing platform effort (DAMPER), SBIR phase 2
NASA Technical Reports Server (NTRS)
Blackburn, John; Smith, Dennis
1992-01-01
Applied Technology Associates, Inc., (ATA) has demonstrated that inertial actuation can be employed effectively in digital, active vibration isolation systems. Inertial actuation involves the use of momentum exchange to produce corrective forces which act directly on the payload being actively isolated. In a typical active vibration isolation system, accelerometers are used to measure the inertial motion of the payload. The signals from the accelerometers are then used to calculate the corrective forces required to counteract, or 'cancel out' the payload motion. Active vibration isolation is common technology, but the use of inertial actuation in such systems is novel, and is the focus of the DAMPER project. A May 1991 report was completed which documented the successful demonstration of inertial actuation, employed in the control of vibration in a single axis. In the 1 degree-of-freedom (1DOF) experiment a set of air bearing rails was used to suspend the payload, simulating a microgravity environment in a single horizontal axis. Digital Signal Processor (DSP) technology was used to calculate in real time, the control law between the accelerometer signals and the inertial actuators. The data obtained from this experiment verified that as much as 20 dB of rejection could be realized by this type of system. A discussion is included of recent tests performed in which vibrations were actively controlled in three axes simultaneously. In the three degree-of-freedom (3DOF) system, the air bearings were designed in such a way that the payload is free to rotate about the azimuth axis, as well as translate in the two horizontal directions. The actuator developed for the DAMPER project has applications beyond payload isolation, including structural damping and source vibration isolation. This report includes a brief discussion of these applications, as well as a commercialization plan for the actuator.
Digital active material processing platform effort (DAMPER), SBIR phase 2
NASA Astrophysics Data System (ADS)
Blackburn, John; Smith, Dennis
1992-11-01
Applied Technology Associates, Inc., (ATA) has demonstrated that inertial actuation can be employed effectively in digital, active vibration isolation systems. Inertial actuation involves the use of momentum exchange to produce corrective forces which act directly on the payload being actively isolated. In a typical active vibration isolation system, accelerometers are used to measure the inertial motion of the payload. The signals from the accelerometers are then used to calculate the corrective forces required to counteract, or 'cancel out' the payload motion. Active vibration isolation is common technology, but the use of inertial actuation in such systems is novel, and is the focus of the DAMPER project. A May 1991 report was completed which documented the successful demonstration of inertial actuation, employed in the control of vibration in a single axis. In the 1 degree-of-freedom (1DOF) experiment a set of air bearing rails was used to suspend the payload, simulating a microgravity environment in a single horizontal axis. Digital Signal Processor (DSP) technology was used to calculate in real time, the control law between the accelerometer signals and the inertial actuators. The data obtained from this experiment verified that as much as 20 dB of rejection could be realized by this type of system. A discussion is included of recent tests performed in which vibrations were actively controlled in three axes simultaneously. In the three degree-of-freedom (3DOF) system, the air bearings were designed in such a way that the payload is free to rotate about the azimuth axis, as well as translate in the two horizontal directions. The actuator developed for the DAMPER project has applications beyond payload isolation, including structural damping and source vibration isolation. This report includes a brief discussion of these applications, as well as a commercialization plan for the actuator.
Active optical control system design of the SONG-China Telescope
NASA Astrophysics Data System (ADS)
Ye, Yu; Kou, Songfeng; Niu, Dongsheng; Li, Cheng; Wang, Guomin
2012-09-01
The standard SONG node structure of control system is presented. The active optical control system of the project is a distributed system, and a host computer and a slave intelligent controller are included. The host control computer collects the information from wave front sensor and sends commands to the slave computer to realize a closed loop model. For intelligent controller, a programmable logic controller (PLC) system is used. This system combines with industrial personal computer (IPC) and PLC to make up a control system with powerful and reliable.
Reduction of vibration by using mechatronical subsystem
NASA Astrophysics Data System (ADS)
Białas, K.; Buchacz, A.
2015-11-01
The primary aim introduced in this paper is synthesis of mechatronical system understand as planning of this type of systems. Mechatronical system is consisted of fundamental mechanical system and subsystem reducing vibration including electric elements. Fundamental system is received applying reverse task of dynamic (synthesis) and it's including inertial and elastic elements. The subsystem includes electric elements by means moving-coil transducer. The synthesis can also be used to change the already existing systems. Due to the method, introduced in this work, may be performed as early as whilst the designing of future functions. Using this way of designing is support for designers of mechanical systems with active reducing of vibrations.
7 CFR 4290.720 - Enterprises that may be ineligible for Financing.
Code of Federal Regulations, 2012 CFR
2012-01-01
... wells, wind farms, or power facilities (including solar, geothermal, hydroelectric, or biomass power... the majority of the activities of the Enterprise. Examples include motion pictures. (e) Farm land... ineligible for Farm Credit System Assistance. If one or more Farm Credit System Institutions or their...
Lowry, C.A.; Hollis, J.H.; de Vries, A.; Pan, B.; Brunet, L.R.; Hunt, J.R.F.; Paton, J.F.R.; van Kampen, E.; Knight, D.M.; Evans, A.K.; Rook, G.A.W.; Lightman, S.L.
2007-01-01
Peripheral immune activation can have profound physiological and behavioral effects including induction of fever and sickness behavior. One mechanism through which immune activation or immunomodulation may affect physiology and behavior is via actions on brainstem neuromodulatory systems, such as serotonergic systems. We have found that peripheral immune activation with antigens derived from the nonpathogenic, saprophytic bacterium, Mycobacterium vaccae, activated a specific subset of serotonergic neurons in the interfascicular part of the dorsal raphe nucleus (DRI) of mice, as measured by quantification of c-Fos expression following intratracheal (12 h) or s.c. (6 h) administration of heat-killed, ultrasonically disrupted M. vaccae, or heat-killed, intact M. vaccae, respectively. These effects were apparent after immune activation by M. vaccae or its components but not by ovalbumin, which induces a qualitatively different immune response. The effects of immune activation were associated with increases in serotonin metabolism within the ventromedial prefrontal cortex, consistent with an effect of immune activation on mesolimbocortical serotonergic systems. The effects of M. vaccae administration on serotonergic systems were temporally associated with reductions in immobility in the forced swim test, consistent with the hypothesis that the stimulation of mesolimbocortical serotonergic systems by peripheral immune activation alters stress-related emotional behavior. These findings suggest that the immune-responsive subpopulation of serotonergic neurons in the DRI is likely to play an important role in the neural mechanisms underlying regulation of the physiological and pathophysiological responses to both acute and chronic immune activation, including regulation of mood during health and disease states. Together with previous studies, these findings also raise the possibility that immune stimulation activates a functionally and anatomically distinct subset of serotonergic neurons, different from the subset of serotonergic neurons activated by anxiogenic stimuli or uncontrollable stressors. Consequently, selective activation of specific subsets of serotonergic neurons may have distinct behavioral outcomes. PMID:17367941
75 FR 16132 - Agency Information Collection Activities: Proposed Collection; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-31
... spectrum of antibacterial activity) and cannot be treated by the most commonly prescribed antibiotics... Information Collection Activities: Proposed Collection; Comment Request AGENCY: Agency for Healthcare Research... support research on healthcare and on systems for the delivery of such care, including activities with...
75 FR 31445 - Agency Information Collection Activities: Proposed Collection; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-03
... broad spectrum of antibacterial activity) and cannot be treated by the most commonly prescribed... Information Collection Activities: Proposed Collection; Comment Request AGENCY: Agency for Healthcare Research... support research on healthcare and on systems for the delivery of such care, including activities with...
Agent Architecture for Aviation Data Integration System
NASA Technical Reports Server (NTRS)
Kulkarni, Deepak; Wang, Yao; Windrem, May; Patel, Hemil; Wei, Mei
2004-01-01
This paper describes the proposed agent-based architecture of the Aviation Data Integration System (ADIS). ADIS is a software system that provides integrated heterogeneous data to support aviation problem-solving activities. Examples of aviation problem-solving activities include engineering troubleshooting, incident and accident investigation, routine flight operations monitoring, safety assessment, maintenance procedure debugging, and training assessment. A wide variety of information is typically referenced when engaging in these activities. Some of this information includes flight recorder data, Automatic Terminal Information Service (ATIS) reports, Jeppesen charts, weather data, air traffic control information, safety reports, and runway visual range data. Such wide-ranging information cannot be found in any single unified information source. Therefore, this information must be actively collected, assembled, and presented in a manner that supports the users problem-solving activities. This information integration task is non-trivial and presents a variety of technical challenges. ADIS has been developed to do this task and it permits integration of weather, RVR, radar data, and Jeppesen charts with flight data. ADIS has been implemented and used by several airlines FOQA teams. The initial feedback from airlines is that such a system is very useful in FOQA analysis. Based on the feedback from the initial deployment, we are developing a new version of the system that would make further progress in achieving following goals of our project.
Framework for the Intelligent Transportation System (ITS) Evaluation : ITS Integration Activities
DOT National Transportation Integrated Search
2006-08-01
Intelligent Transportation Systems (ITS) represent a significant opportunity to improve the efficiency and safety of the surface transportation system. ITS includes technologies to support information processing, communications, surveillance and cont...
Heterodyne systems and technology, part 1. [conferences
NASA Technical Reports Server (NTRS)
1980-01-01
Various aspects of optical heterodyning are considered. Topics covered heterodyning throughout the electromagnetic spectrum including detectors, local oscillators, tunable diode lasers, astronomical systems, and environmental sensors, with both active and passive systems represented.
Enclosure for thermoelectric refrigerator and method
NASA Technical Reports Server (NTRS)
Park, Brian V. (Inventor); McGrath, Ralph D. (Inventor)
1997-01-01
An enclosed structure is provided for use with a refrigerator having a door assembly. The enclosed structure preferably contains superinsulation materials and a plurality of matching drawers. The enclosed structure preferably includes corner joints which minimize thermal energy transfer between adjacent superinsulation panels. The refrigerator may include a cooling system having a thermoelectric device for maintaining the temperature within the refrigerator at selected values. If desired, a fluid cooling system and an active gasket may also be provided between the door assembly and the enclosed structure. The fluid cooling system preferably includes a second thermoelectric device to maintain the temperature of fluid flowing through the active gasket at a selected value. The drawers associated with the refrigerator may be used for gathering, processing, shipping and storing food or other perishable items.
Optimal integral force feedback for active vibration control
NASA Astrophysics Data System (ADS)
Teo, Yik R.; Fleming, Andrew J.
2015-11-01
This paper proposes an improvement to Integral Force Feedback (IFF), which is a popular method for active vibration control of structures and mechanical systems. Benefits of IFF include robustness, guaranteed stability and simplicity. However, the maximum damping performance is dependent on the stiffness of the system; hence, some systems cannot be adequately controlled. In this paper, an improvement to the classical force feedback control scheme is proposed. The improved method achieves arbitrary damping for any mechanical system by introducing a feed-through term. The proposed improvement is experimentally demonstrated by actively damping an objective lens assembly for a high-speed confocal microscope.
DOE Office of Scientific and Technical Information (OSTI.GOV)
NONE
This report summarizes system performance and major project activities over the first four months of 1995. The quarterly technical reports that have been issued for the past several years are being replaced this year by two technical reports covering the January--April and May--August periods, respectively. Performance data for the last four months of the year will be included in the 1995 Progress Report. Principal activities during the first four months of 1995 included bringing two new systems on line, hosting a two-day Balance of System and Procurement workshop at the Davis site, completing and issuing the EMT Five-Year Assessment Report,more » and preparing for a management transition in 1996.« less
International Space Station Environmental Control and Life Support System Status: 2014-2015
NASA Technical Reports Server (NTRS)
Williams, David E.; Gentry, Gregory J.
2015-01-01
The International Space Station (ISS) Environmental Control and Life Support (ECLS) system includes regenerative and non-regenerative technologies that provide the basic life support functions to support the crew, while maintaining a safe and habitable shirtsleeve environment. This paper provides a summary of the U.S. ECLS system activities over the past year and the impacts of the international partners' activities on them, covering the period of time between March 2014 and February 2015. The ISS continued permanent crew operations including the continuation of six crew members being on ISS. Work continues on the commercial crew vehicles, and work to try and extend ISS service life.
NASA Technical Reports Server (NTRS)
Swenson, Charles
2016-01-01
The Active CryoCubeSat project will demonstrate an advanced thermal control system for a 6-Unit (6U) CubeSat platform. A miniature, active thermal control system, in which a fluid is circulated in a closed loop from thermal loads to radiators, will be developed. A miniature cryogenic cooler will be integrated with this system to form a two-stage thermal control system. Key components will be miniaturized by using advanced additive manufacturing techniques resulting in a thermal testbed for proving out these technologies. Previous CubeSat missions have not tackled the problem of active thermal control systems nor have any past or current CubeSat missions included cryogenic instrumentation. This Active CryoCubeSat development effort will provide completely new capacities for CubeSats and constitutes a major advancement over the state-of-the-art in CubeSat thermal control.
Inner Space and Outer Space: Pressure Suits & Life Support Systems for Space Workers
NASA Technical Reports Server (NTRS)
Webbon, Bruce
2004-01-01
This slide presentation presents an overview of work system requirements, extravehicular activity system evolution, key issues, future needs, and a summary. Key issues include pressure suits, life support systems, system integration, biomedical requirements, and work and mobility aids.
Recruitment of Physicians for the Active Army, 1975-1980
1975-06-06
its supporting assets includinF the personnel counselor system and contract advertising capabilities: and, (4) comparison of physician pro curement...any criti- cism directed toward recruitment efforts has inhibited the use of available assets to include common corvmercial advertising techniques. 1 4...current Army procurement system and its supporting assets including the personnel counselor system ana contract advertising capabil- ities; and, (4
Prototype solar heating and cooling systems including potable hot water
NASA Technical Reports Server (NTRS)
1978-01-01
These combined quarterly reports summarize the activities from November 1977 through September 1978, and over the progress made in the development, delivery and support of two prototype solar heating and cooling systems including potable hot water. The system consists of the following subsystems: solar collector, auxiliary heating, potable hot water, storage, control, transport, and government-furnished site data acquisition.
SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips
Vo-Dinh, Tuan [Knoxville, TN
2007-09-11
A Raman integrated sensor system for the detection of targets including biotargets includes at least one sampling platform, at least one receptor probe disposed on the sampling platform, and an integrated circuit detector system communicably connected to the receptor. The sampling platform is preferably a Raman active surface-enhanced scattering (SERS) platform, wherein the Raman sensor is a SERS sensor. The receptors can include at least one protein receptor and at least one nucleic acid receptor.
1980-08-01
or injury ; includes primarily patients whose actual impairment is related to neuromusculoskeletal, pulmonary, and cardiovasular systems; includes the...disease or injury ; includes primarily patients whose actual impairment is related to neuromusculoskeletal, pulmonary, and cardiovascular systems...orthodontics, endo - dontics, oral hygiene, preventive dentistry, and radiodontics to eligible dental patients. (Formerly in code H113 - Dental Care.) N312
Cassidy, Christine; MacDonald, Noni E; Steenbeek, Audrey; Ortiz, Justin R; Zuber, Patrick L F; Top, Karina A
2016-08-02
Strengthening antenatal care as a platform for maternal immunization is a priority of the World Health Organization (WHO). Systematic surveillance for adverse events following immunization (AEFI) in pregnancy is needed to identify vaccine safety events. We sought to identify active and passive AEFI surveillance systems for pregnant women and infants. Representatives from all National Pharmacovigilance Centers and a convenience sample of vaccine safety experts were invited to complete a 14-item online survey in English, French or Spanish. The survey captured maternal immunization policies, and active and passive AEFI surveillance systems for pregnant women and infants in respondents' countries. The analysis was descriptive. We received responses from 51/185 (28%) invited persons from 47/148 (32%) countries representing all WHO regions, and low, middle and high-income countries. Thirty countries had national immunization policies targeting pregnant women. Eleven countries had active surveillance systems to detect serious AEFI in pregnant women and/or their infants, including six low and middle-income countries (LMIC). Thirty-nine countries had passive surveillance systems, including 23 LMIC. These active and passive surveillance programs cover approximately 8% and 56% of the worldwide annual birth cohort, respectively. Data from one active and four passive systems have been published. We identified 50 active and passive AEFI surveillance systems for pregnant women and infants, but few have published their findings. AEFI surveillance appears to be feasible in low and high resource settings. Further expansion of AEFI surveillance for pregnant women and sharing of vaccine safety information will provide additional evidence in support of maternal immunization policies.
Spacecraft capture and docking system
NASA Technical Reports Server (NTRS)
Kong, Kinyuen (Inventor); Rafeek, Shaheed (Inventor); Myrick, Thomas (Inventor)
2001-01-01
A system for capturing and docking an active craft to a passive craft has a first docking assembly on the active craft with a first contact member and a spike projecting outwardly, a second docking assembly on the passive craft having a second contact member and a flexible net deployed over a target area with an open mesh for capturing the end of the spike of the active craft, and a motorized net drive for reeling in the net and active craft to mate with the passive craft's docking assembly. The spike has extendable tabs to allow it to become engaged with the net. The net's center is coupled to a net spool for reeling in. An alignment funnel has inclined walls to guide the net and captured spike towards the net spool. The passive craft's docking assembly includes circumferentially spaced preload wedges which are driven to lock the wedges against the contact member of the active craft. The active craft's docking assembly includes a rotary table and drive for rotating it to a predetermined angular alignment position, and mating connectors are then engaged with each other. The system may be used for docking spacecraft in zero or low-gravity environments, as well as for docking underwater vehicles, docking of ancillary craft to a mother craft in subsonic flight, in-flight refueling systems, etc.
Effects of microgravity on the immune system
NASA Technical Reports Server (NTRS)
Sonnenfeld, Gerald; Taylor, Gerald R.
1991-01-01
Changes in resistance to bacterial and viral infections in Apollo crew members has stimulated interest in the study of immunity and space flight. Results of studies from several laboratories in both humans and rodents have indicated alterations after space flight that include the following immunological parameters: thymus size, lymphocyte blastogenesis, interferon and interleukin production, natural killer cell activity, cytotoxic T-cell activity, leukocyte subset population distribution, response of bone marrow cells to colony stimulating factors, and delayed hypersensitivity skin test reactivity. The interactions of the immune system with other physiological systems, including muscle, bone, and the nervous system, may play a major role in the development of these immunological parameters during and after flight. There may also be direct effects of space flight on immune responses.
NASA Technical Reports Server (NTRS)
Hielkema, J. U.; Howard, J. A.; Tucker, C. J.; Van Ingen Schenau, H. A.
1987-01-01
The African real time environmental monitoring using imaging satellites (Artemis) system, which should monitor precipitation and vegetation conditions on a continental scale, is presented. The hardware and software characteristics of the system are illustrated and the Artemis databases are outlined. Plans for the system include the use of hourly digital Meteosat data and daily NOAA/AVHRR data to study environmental conditions. Planned mapping activities include monthly rainfall anomaly maps, normalized difference vegetation index maps for ten day and monthly periods with a spatial resolution of 7.6 km, ten day crop/rangeland moisture availability maps, and desert locust potential breeding activity factor maps for a plague prevention program.
Autonomic Reactivity of Children to Separation and Reunion with Foster Parents
ERIC Educational Resources Information Center
Oosterman, Mirjam; Schuengel, Carlo
2007-01-01
Objective: To determine whether foster children showed different autonomic nervous system activity on separation and reunion than control children. Autonomic nervous system activity in foster children was examined in relation to time in placement and disinhibited attachment. Method: The sample included 60 foster and 50 control children between 2…
40 CFR 60.2735 - Is there a minimum amount of monitoring data I must obtain?
Code of Federal Regulations, 2011 CFR
2011-07-01
....2770(o) of this part), and required monitoring system quality assurance or quality control activities... periods, and required monitoring system quality assurance or quality control activities including, as... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Is there a minimum amount of monitoring...
Seal Related Development Activities at EG/G
NASA Technical Reports Server (NTRS)
Greiner, Harold F.
1991-01-01
Seal related development activities including modeling, analysis, and performance testing are described for several current seal related projects. Among the current seal related projects are the following: high pressure gas sealing systems for turbomachinery; brush seals for gas path sealing in gas turbines; and tribological material evaluation for wear surfaces in sealing systems.
Models and Systems for Structurization of Knowledge in Training
ERIC Educational Resources Information Center
Pelin, Nicolae; Pelin, Serghei
2007-01-01
In this work the problems of the automated structurization and activation of the knowledge, saved and used by mankind, during the organization and training, and also that knowledge which are generated by experts (including teachers) in the current activity, are analyzed. The purpose--the further perfection of methods and systems of the automated…
The Dimensions of the Solar System
ERIC Educational Resources Information Center
Schneider, Stephen E.; Davis, Kathleen S.
2007-01-01
A few new wrinkles have been added to the popular activity of building a scale model of the solar system. Students can learn about maps and scaling using easily accessible online resources that include satellite images. This is accomplished by taking advantage of some of the special features of Google Earth. This activity gives students a much…
Cortisol and Children's Adjustment: The Moderating Role of Sympathetic Nervous System Activity
ERIC Educational Resources Information Center
El-Sheikh, Mona; Erath, Stephen A.; Buckhalt, Joseph A.; Granger, Douglas A.; Mize, Jacquelyn
2008-01-01
We examined relations among cortisol, markers of sympathetic nervous system (SNS) activity (including salivary alpha-amylase and skin conductance level), and children's adjustment. We also tested the Bauer et al. ("Journal of Developmental and Behavioral Pediatrics," 23(2), 102-113, 2002) hypothesis that interactions between the SNS and cortisol…
School Principals' Agency as Reflected by Extracurricular Activities in the Israeli Education System
ERIC Educational Resources Information Center
Yemini, Miri; Addi-Raccah, Audrey
2013-01-01
This study examines the nature and extent of extracurricular activities in the Palestinian Arab, Jewish Religious and Jewish Secular educational sectors (Israeli education system also includes the Ultra-Orthodox sector with its own management, monitoring and governance apparatus.) in Israel, in order to characterise the contextual variables that…
Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-26
... ``job clubs'' have evolved into one of several important activities used by the public workforce system... are formally run through the public workforce system--including at Department of Labor funded American... communities; (2) documenting how they differ from and are similar to the job clubs operated by publicly...
International Space Station ECLSS Technical Task Agreement Summary Report
NASA Technical Reports Server (NTRS)
Ray, C. D. (Compiler); Salyer, B. H. (Compiler)
1999-01-01
This Technical Memorandum provides a summary of current work accomplished under Technical Task Agreement (TTA) by the Marshall Space Flight Center (MSFC) regarding the International Space Station (ISS) Environmental Control and Life Support System (ECLSS). Current activities include ECLSS component design and development, computer model development, subsystem/integrated system testing, life testing, and general test support provided to the ISS program. Under ECLSS design, MSFC was responsible for the six major ECLSS functions, specifications and standard, component design and development, and was the architectural control agent for the ISS ECLSS. MSFC was responsible for ECLSS analytical model development. In-house subsystem and system level analysis and testing were conducted in support of the design process, including testing air revitalization, water reclamation and management hardware, and certain nonregenerative systems. The activities described herein were approved in task agreements between MSFC and NASA Headquarters Space Station Program Management Office and their prime contractor for the ISS, Boeing. These MSFC activities are in line to the designing, development, testing, and flight of ECLSS equipment planned by Boeing. MSFC's unique capabilities for performing integrated systems testing and analyses, and its ability to perform some tasks cheaper and faster to support ISS program needs, are the basis for the TTA activities.
A Framework for Performing V&V within Reuse-Based Software Engineering
NASA Technical Reports Server (NTRS)
Addy, Edward A.
1996-01-01
Verification and validation (V&V) is performed during application development for many systems, especially safety-critical and mission-critical systems. The V&V process is intended to discover errors, especially errors related to critical processing, as early as possible during the development process. Early discovery is important in order to minimize the cost and other impacts of correcting these errors. In order to provide early detection of errors, V&V is conducted in parallel with system development, often beginning with the concept phase. In reuse-based software engineering, however, decisions on the requirements, design and even implementation of domain assets can be made prior to beginning development of a specific system. In this case, V&V must be performed during domain engineering in order to have an impact on system development. This paper describes a framework for performing V&V within architecture-centric, reuse-based software engineering. This framework includes the activities of traditional application-level V&V, and extends these activities into domain engineering and into the transition between domain engineering and application engineering. The framework includes descriptions of the types of activities to be performed during each of the life-cycle phases, and provides motivation for the activities.
Earth observation archive activities at DRA Farnborough
NASA Technical Reports Server (NTRS)
Palmer, M. D.; Williams, J. M.
1993-01-01
Space Sector, Defence Research Agency (DRA), Farnborough have been actively involved in the acquisition and processing of Earth Observation data for over 15 years. During that time an archive of over 20,000 items has been built up. This paper describes the major archive activities, including: operation and maintenance of the main DRA Archive, the development of a prototype Optical Disc Archive System (ODAS), the catalog systems in use at DRA, the UK Processing and Archive Facility for ERS-1 data, and future plans for archiving activities.
Project WET: Facilitator Handbook for Implementation of Activities in Virginia.
ERIC Educational Resources Information Center
Sevebeck, Kathryn P.
This handbook features ideas for implementing Project WET activities in Virginia. Project WET activities are designed for a variety of educational programs and can be used to complement existing curricula while addressing curricular objectives and educational standards nationwide. Activities include: (1) "Life Systems"; (2)…
Highly active thermally stable nanoporous gold catalyst
DOE Office of Scientific and Technical Information (OSTI.GOV)
Biener, Juergen; Wittstock, Arne; Biener, Monika M.
In one embodiment, a system includes a nanoporous gold structure and a plurality of oxide particles deposited on the nanoporous gold structure; the oxide particles are characterized by a crystalline phase. In another embodiment, a method includes depositing oxide nanoparticles on a nanoporous gold support to form an active structure and functionalizing the deposited oxide nanoparticles.
48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities
Code of Federal Regulations, 2010 CFR
2010-10-01
... AIDAR 715.613-71. 2. Purpose The collaborative assistance system is designed to: (a) Increase the joint..., including the design stage of a technical assistance project. 3. Policy The collaborative assistance... joint research and development—including training. In such an activity, the difficulty in defining, in...
48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities
Code of Federal Regulations, 2013 CFR
2013-10-01
... AIDAR 715.613-71. 2. Purpose The collaborative assistance system is designed to: (a) Increase the joint..., including the design stage of a technical assistance project. 3. Policy The collaborative assistance... joint research and development—including training. In such an activity, the difficulty in defining, in...
48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities
Code of Federal Regulations, 2014 CFR
2014-10-01
... AIDAR 715.613-71. 2. Purpose The collaborative assistance system is designed to: (a) Increase the joint..., including the design stage of a technical assistance project. 3. Policy The collaborative assistance... joint research and development—including training. In such an activity, the difficulty in defining, in...
48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities
Code of Federal Regulations, 2012 CFR
2012-10-01
... AIDAR 715.613-71. 2. Purpose The collaborative assistance system is designed to: (a) Increase the joint..., including the design stage of a technical assistance project. 3. Policy The collaborative assistance... joint research and development—including training. In such an activity, the difficulty in defining, in...
48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities
Code of Federal Regulations, 2011 CFR
2011-10-01
... AIDAR 715.613-71. 2. Purpose The collaborative assistance system is designed to: (a) Increase the joint..., including the design stage of a technical assistance project. 3. Policy The collaborative assistance... joint research and development—including training. In such an activity, the difficulty in defining, in...
Optics: Light, Color, and Their Uses. An Educator's Guide With Activities In Science and Mathematics
NASA Technical Reports Server (NTRS)
2000-01-01
This document includes information on the Chandra X-Ray Observatory, the Hubble Space Telescope, the Next Generation Space Telescope, Soft X-Ray Imager, and the Lightning Imaging System. Classroom activities from grades K-12 are included, focusing on light and color, using mirrors, lenses, prisms, and filters.
The Fact Book: Report for the Florida College System, 2014
ERIC Educational Resources Information Center
Florida Department of Education, 2014
2014-01-01
This 2014 fact book for the Florida College System is divided into the following categories: (1) Student Information, which includes fall, annual, FTE, and program enrollment statistics, as well as credit program completion statistics; (2) Employee Information, which includes statistics regarding employee headcount by occupational activity, and…
The Fact Book: Report for the Florida College System, 2015
ERIC Educational Resources Information Center
Florida Department of Education, 2015
2015-01-01
This 2015 fact book for the Florida College System is divided into the following categories: (1) Student Information, which includes fall, annual, FTE, and program enrollment statistics, as well as credit program completion statistics; (2) Employee Information, which includes statistics regarding employee headcount by occupational activity, and…
The Fact Book: Report for the Florida College System, 2016
ERIC Educational Resources Information Center
Florida Department of Education, 2016
2016-01-01
This 2016 fact book for the Florida College System is divided into the following categories: (1) Student Information, which includes fall, annual, FTE, and program enrollment statistics, as well as credit program completion statistics; (2) Employee Information, which includes statistics regarding employee headcount by occupational activity and…
NASA Technical Reports Server (NTRS)
Thomas, R. L.; Donovon, R. M.
1978-01-01
The development associated with large wind turbine systems is briefly described. The scope of this activity includes the development of several large wind turbines ranging in size from 100 kW to several megawatt levels. A description of the wind turbine systems, their programmatic status and a summary of their potential costs is included.
Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-28
... bring together experts from diverse backgrounds and experiences including electric system operators... transmission switching; AC optimal power flow modeling; and use of active and dynamic transmission ratings. In... variability of the system, including forecast error? [cir] How can outage probability be captured in...
Domains of the Florida Performance Measurement System.
ERIC Educational Resources Information Center
Florida State Dept. of Education, Tallahassee.
This monograph sets forth in detail the concepts included in the five domains of teaching as identified by the Florida Coalition for the Development of a Performance Evaluation System. The first domain, planning, includes the concepts: (1) content coverage; (2) utilization of instructional materials; (3) activity structure; (4) goal focusing; and…
Solar parabolic dish technology evaluation report
NASA Technical Reports Server (NTRS)
Lucas, J. W.
1984-01-01
The activities of the JPL Solar Thermal Power Systems Parabolic Dish Project for FY 1983 are summarized. Included are discussions on designs of module development including concentrator, receiver, and power conversion subsystems together with a separate discussion of field tests, Small Community Experiment system development, and tests at the Parabolic Dish Test Site.
Mission Data System Java Edition Version 7
NASA Technical Reports Server (NTRS)
Reinholtz, William K.; Wagner, David A.
2013-01-01
The Mission Data System framework defines closed-loop control system abstractions from State Analysis including interfaces for state variables, goals, estimators, and controllers that can be adapted to implement a goal-oriented control system. The framework further provides an execution environment that includes a goal scheduler, execution engine, and fault monitor that support the expression of goal network activity plans. Using these frameworks, adapters can build a goal-oriented control system where activity coordination is verified before execution begins (plan time), and continually during execution. Plan failures including violations of safety constraints expressed in the plan can be handled through automatic re-planning. This version optimizes a number of key interfaces and features to minimize dependencies, performance overhead, and improve reliability. Fault diagnosis and real-time projection capabilities are incorporated. This version enhances earlier versions primarily through optimizations and quality improvements that raise the technology readiness level. Goals explicitly constrain system states over explicit time intervals to eliminate ambiguity about intent, as compared to command-oriented control that only implies persistent intent until another command is sent. A goal network scheduling and verification process ensures that all goals in the plan are achievable before starting execution. Goal failures at runtime can be detected (including predicted failures) and handled by adapted response logic. Responses can include plan repairs (try an alternate tactic to achieve the same goal), goal shedding, ignoring the fault, cancelling the plan, or safing the system.
Liu, Qingyou; Tang, Yang; Huang, Chongjun; Xie, Chong
2015-01-01
There are some disadvantages for existing heave compensation systems of drill string used for the Floating Drilling Platform (FDP), including high energy consumption, large and complex structure, and expensive manufacturing and maintenance costs. In view of the above, we present a streamlined mechanical semi-active heave compensation system (MSAHC) in this study. This system consists of active compensation part with the pinion and rack and passive compensation part. In order to evaluate system performance of the MSAHC, we establish its simulation model with AMEsim software. In the process of simulation, displacement of rotary hook and energy consumption is regarded as performance parameters of the system. And the change rule of two performance parameters are analyzed by changing these design parameters including gear radius of the pinion and rack, scale coefficient of PID, rotary hook load, heave height and heave period of the FDP, and accumulator volume. Then, based on the simulation results of the MSAHC system performance, we have selected out a best set of design parameters from them. Moreover, the feasibility of the design scheme of the MSAHC is effectively verified by comparison with the existing three heave compensation system. The result shows that the energy consumption of the MSAHC is lower than the active heave compensation system (AHC) and the semi-active heave compensation system (SAHC) when achieving a same compensation effect as well as the accumulator volume of MSAHC is half of the passive heave compensation system (PHC). Therefore, the new designed MSAHC not only ensure compensation effect but also lower energy consumption, and its structure is simplified by adopting the simple mechanical structure to decrease manufacturing cost, maintenance cost and floor space. PMID:26186620
49 CFR 234.106 - Partial activation.
Code of Federal Regulations, 2014 CFR
2014-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.107 - False activation.
Code of Federal Regulations, 2014 CFR
2014-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.105 - Activation failure.
Code of Federal Regulations, 2014 CFR
2014-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.107 - False activation.
Code of Federal Regulations, 2012 CFR
2012-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.107 - False activation.
Code of Federal Regulations, 2013 CFR
2013-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.106 - Partial activation.
Code of Federal Regulations, 2012 CFR
2012-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.105 - Activation failure.
Code of Federal Regulations, 2013 CFR
2013-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.106 - Partial activation.
Code of Federal Regulations, 2013 CFR
2013-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
49 CFR 234.105 - Activation failure.
Code of Federal Regulations, 2012 CFR
2012-10-01
... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND EMERGENCY NOTIFICATION SYSTEMS Response to Credible Reports of Warning System Malfunction at Highway-Rail...
Exploring Techniques for Vision Based Human Activity Recognition: Methods, Systems, and Evaluation
Xu, Xin; Tang, Jinshan; Zhang, Xiaolong; Liu, Xiaoming; Zhang, Hong; Qiu, Yimin
2013-01-01
With the wide applications of vision based intelligent systems, image and video analysis technologies have attracted the attention of researchers in the computer vision field. In image and video analysis, human activity recognition is an important research direction. By interpreting and understanding human activities, we can recognize and predict the occurrence of crimes and help the police or other agencies react immediately. In the past, a large number of papers have been published on human activity recognition in video and image sequences. In this paper, we provide a comprehensive survey of the recent development of the techniques, including methods, systems, and quantitative evaluation of the performance of human activity recognition. PMID:23353144
Barium iodide and strontium iodide crystals and scintillators implementing the same
Payne, Stephen A.; Cherepy, Nerine; Pedrini, Christian; Burger, Arnold
2016-09-13
In one embodiment, a crystal includes at least one metal halide; and an activator dopant comprising ytterbium. In another general embodiment, a scintillator optic includes: at least one metal halide doped with a plurality of activators, the plurality of activators comprising: a first activator comprising europium, and a second activator comprising ytterbium. In yet another general embodiment, a method for manufacturing a crystal suitable for use in a scintillator includes mixing one or more salts with a source of at least one dopant activator comprising ytterbium; heating the mixture above a melting point of the salt(s); and cooling the heated mixture to a temperature below the melting point of the salts. Additional materials, systems, and methods are presented.
Chalikias, George; Tziakas, Dimitrios; Chizzolini, Carlo; Ribi, Camillo; Trendelenburg, Marten; Eisenberger, Ute; Hauser, Thomas; Pasch, Andreas; Huynh-Do, Uyen; Arampatzis, Spyridon
2018-01-01
Background Systemic lupus erythematosus (SLE) is associated with severe cardiovascular complications. The T50 score is a novel functional blood test quantifying calcification propensity in serum. High calcification propensity (or low T50) is a strong and independent determinant of all-cause mortality in various patient populations. Methods A total of 168 patients with ≥ 4 American College of Rheumatology (ACR) diagnostic criteria from the Swiss Systemic lupus erythematosus Cohort Study (SSCS) were included in this analysis. Serum calcification propensity was assessed using time-resolved nephelometry. Results The cohort mainly consisted of female (85%), middle-aged (43±14 years) Caucasians (77%). The major determinants of T50 levels included hemoglobin, serum creatinine and serum protein levels explaining 43% of the variation at baseline. Integrating disease activity (SELENA-SLEDAI) into this multivariate model revealed a significant association between disease activity and T50 levels. In a subgroup analysis considering only patients with active disease (SELENA-SLEDAI score ≥4) we found a negative association between T50 and SELENA-SLEDAI score at baseline (Spearman’s rho -0.233, P = 0.02). Conclusions Disease activity and T50 are closely associated. Moreover, T50 levels identify a subgroup of SLE patients with ongoing systemic inflammation as mirrored by increased disease activity. T50 could be a promising biomarker reflecting SLE disease activity and might offer an earlier detection tool for high-risk patients. PMID:29364894
Immune biomarkers in older adults: Role of physical activity.
Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Marcos-Pérez, Diego; López-Cortón, Ana; Strasser, Barbara; Fuchs, Dietmar; Laffon, Blanca; Millán-Calenti, José C; Pásaro, Eduardo
2017-01-01
Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and aging or age-related outcomes, such as sarcopenia, depression, and neurodegenerative disorders. Physical activity is known to improve muscle function and to exert a number of benefits on older adult health, including reduced risk for heart and metabolic system chronic diseases. However, the positive influence of physical activity on the immune system has not been elucidated. In order to shed light on the role of physical activity in immune responses of older individuals, a number of immunological parameters comprising % lymphocyte subsets (CD3 + , CD4 + , CD8 + , CD19 + , and CD16 + 56 + ) and serum levels of neopterin and tryptophan metabolism products were evaluated in peripheral blood samples of older adults performing normal (N = 170) or reduced (N = 89) physical activity. In addition, the potential influence of other clinical and epidemiological factors was also considered. Results showed that subjects with reduced physical activity displayed significantly higher levels of CD4 + /CD8 + ratio, kynurenine/tryptophan ratio, and serum neopterin, along with lower %CD19 + cells and tryptophan concentrations. Further, some immunological biomarkers were associated with cognitive impairment and functional status. These data contribute to reinforce the postulation that physical activity supports healthy aging, particularly by helping to protect the immunological system from aging-related changes.
OBESITY-INDUCED HYPERTENSION: INTERACTION OF NEUROHUMORAL AND RENAL MECHANISMS
Hall, John E.; do Carmo, Jussara M.; da Silva, Alexandre A.; Wang, Zhen; Hall, Michael E.
2015-01-01
Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension, accounting for 65–75% of the risk for human primary (essential) hypertension. Increased renal tubular sodium reabsorption impairs pressure natriuresis and plays an important role in initiating obesity hypertension. The mediators of abnormal kidney function and increased blood pressure during development of obesity hypertension include 1) physical compression of the kidneys by fat in and around the kidneys, 2) activation of the renin-angiotensin-aldosterone system (RAAS), and 3) increased sympathetic nervous system (SNS) activity. Activation of the RAAS system is likely due, in part, to renal compression as well as SNS activation. However, obesity also causes mineralocorticoid receptor activation independent of aldosterone or angiotensin II. The mechanisms for SNS activation in obesity have not been fully elucidated but appear to require leptin and activation of the brain melanocortin system. With prolonged obesity and development of target organ injury, especially renal injury, obesity-associated hypertension becomes more difficult to control, often requiring multiple antihypertensive drugs and treatment of other risk factors, including dyslipidemia, insulin resistance and diabetes, and inflammation. Unless effective anti-obesity drugs are developed, the impact of obesity on hypertension and related cardiovascular, renal and metabolic disorders is likely to become even more important in the future as the prevalence of obesity continues to increase. PMID:25767285
DOE Office of Scientific and Technical Information (OSTI.GOV)
Christoph, G.G; Jackson, K.A.; Neuman, M.C.
An effective method for detecting computer misuse is the automatic auditing and analysis of on-line user activity. This activity is reflected in the system audit record, by changes in the vulnerability posture of the system configuration, and in other evidence found through active testing of the system. In 1989 we started developing an automatic misuse detection system for the Integrated Computing Network (ICN) at Los Alamos National Laboratory. Since 1990 this system has been operational, monitoring a variety of network systems and services. We call it the Network Anomaly Detection and Intrusion Reporter, or NADIR. During the last year andmore » a half, we expanded NADIR to include processing of audit and activity records for the Cray UNICOS operating system. This new component is called the UNICOS Real-time NADIR, or UNICORN. UNICORN summarizes user activity and system configuration information in statistical profiles. In near real-time, it can compare current activity to historical profiles and test activity against expert rules that express our security policy and define improper or suspicious behavior. It reports suspicious behavior to security auditors and provides tools to aid in follow-up investigations. UNICORN is currently operational on four Crays in Los Alamos` main computing network, the ICN.« less
Contents of the JPL Distributed Active Archive Center (DAAC) archive, version 2-91
NASA Technical Reports Server (NTRS)
Smith, Elizabeth A. (Editor); Lassanyi, Ruby A. (Editor)
1991-01-01
The Distributed Active Archive Center (DAAC) archive at the Jet Propulsion Laboratory (JPL) includes satellite data sets for the ocean sciences and global change research to facilitate multidisciplinary use of satellite ocean data. Parameters include sea surface height, surface wind vector, sea surface temperature, atmospheric liquid water, and surface pigment concentration. The Jet Propulsion Laboratory DAAC is an element of the Earth Observing System Data and Information System (EOSDIS) and will be the United States distribution site for the Ocean Topography Experiment (TOPEX)/POSEIDON data and metadata.
NASA Technical Reports Server (NTRS)
1994-01-01
The Physical Oceanography Distributed Active Archive Center (PO.DAAC) archive at the Jet Propulsion Laboratory (JPL) includes satellite data sets for the ocean sciences and global-change research to facilitate multidisciplinary use of satellite ocean data. Parameters include sea-surface height, surface-wind vector, sea-surface temperature, atmospheric liquid water, and integrated water vapor. The JPL PO.DAAC is an element of the Earth Observing System Data and Information System (EOSDIS) and is the United States distribution site for Ocean Topography Experiment (TOPEX)/POSEIDON data and metadata.
Sea buckthorn as a source of important bioactive compounds in cardiovascular diseases.
Olas, Beata
2016-11-01
Hippophae rhamnoides (sea buckthorn) offers many health benefits. It has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. In addition, sea buckthorn has antibacterial and antiviral properties. The leaves and fruits of the plant, and its oils, are sources of many bioactive substances including vitamins (A, C and E), unsaturated fatty acids, phenolic compounds, especially flavonoids, and phytosterols, which bestow positive effects on the cardiovascular system. This review article summarizes the current knowledge of the biological roles of sea buckthorn in cardiovascular diseases. Copyright © 2016 Elsevier Ltd. All rights reserved.
Marshall Space Flight Center battery activity
NASA Technical Reports Server (NTRS)
Lowery, Eric
1993-01-01
The topics covered are presented in viewgraph form and include a flight program history and in-house activities. Some of the in-house activities addressed include secondary battery/cell testing and Hubble Space Telescope Test data updates involving the NiCd type 40 test - battery 1 and 2, the NiCd type 41 test battery, the general electric battery, the NiCd six-battery system, the six four-cell packs, fourteen-cell pack, three four-cell packs, the NiH2 six-battery system, and the flight spare battery. A general test data update is also presented for the twelve-cell pack, the four four-cell packs, the reconditioning test, and planned Ni-MH testing.
How-to-Do-It: Muscle Activities that Stretch the Mind.
ERIC Educational Resources Information Center
Hanegan, James L.; McKean, Heather R.
1989-01-01
The construction of a wooden model of the musculoskeletal system which can be used to investigate the physical properties of muscles without sacrificing laboratory animals is presented. Six activities are included with answers. Additional activities are suggested. (CW)
The quartet theory of human emotions: An integrative and neurofunctional model.
Koelsch, Stefan; Jacobs, Arthur M; Menninghaus, Winfried; Liebal, Katja; Klann-Delius, Gisela; von Scheve, Christian; Gebauer, Gunter
2015-06-01
Despite an explosion of research in the affective sciences during the last few decades, interdisciplinary theories of human emotions are lacking. Here we present a neurobiological theory of emotions that includes emotions which are uniquely human (such as complex moral emotions), considers the role of language for emotions, advances the understanding of neural correlates of attachment-related emotions, and integrates emotion theories from different disciplines. We propose that four classes of emotions originate from four neuroanatomically distinct cerebral systems. These emotional core systems constitute a quartet of affect systems: the brainstem-, diencephalon-, hippocampus-, and orbitofrontal-centred affect systems. The affect systems were increasingly differentiated during the course of evolution, and each of these systems generates a specific class of affects (e.g., ascending activation, pain/pleasure, attachment-related affects, and moral affects). The affect systems interact with each other, and activity of the affect systems has effects on - and interacts with - biological systems denoted here as emotional effector systems. These effector systems include motor systems (which produce actions, action tendencies, and motoric expression of emotion), peripheral physiological arousal, as well as attentional and memory systems. Activity of affect systems and effector systems is synthesized into an emotion percept (pre-verbal subjective feeling), which can be transformed (or reconfigured) into a symbolic code such as language. Moreover, conscious cognitive appraisal (involving rational thought, logic, and usually language) can regulate, modulate, and partly initiate, activity of affect systems and effector systems. Our emotion theory integrates psychological, neurobiological, sociological, anthropological, and psycholinguistic perspectives on emotions in an interdisciplinary manner, aiming to advance the understanding of human emotions and their neural correlates. Copyright © 2015 Elsevier B.V. All rights reserved.
Power systems for production, construction, life support and operations in space
NASA Technical Reports Server (NTRS)
Sovie, Ronald J.
1988-01-01
As one looks to man's future in space it becomes obvious that unprecedented amounts of power are required for the exploration, colonization, and exploitation of space. Activities envisioned include interplanetary travel and LEO to GEO transport using electric propulsion, Earth and lunar observatories, advance space stations, free-flying manufacturing platforms, communications platforms, and eventually evolutionary lunar and Mars bases. These latter bases would start as camps with modest power requirements (kWes) and evolve to large bases as manufacturing, food production, and life support materials are developed from lunar raw materials. These latter activities require very robust power supplies (MWes). The advanced power system technologies being pursued by NASA to fulfill these future needs are described. Technologies discussed will include nuclear, photovoltaic, and solar dynamic space power systems, including energy storage, power conditioning, power transmission, and thermal management. The state-of-the-art and gains to be made by technology advancements will be discussed. Mission requirements for a variety of applications (LEO, GEO, lunar, and Martian) will be treated, and data for power systems ranging from a few kilowatts to megawatt power systems will be represented. In addition the space power technologies being initiated under NASA's new Civilian Space Technology Initiative (CSTI) and Space Leadership Planning Group Activities will be discussed.
Power systems for production, construction, life support, and operations in space
NASA Technical Reports Server (NTRS)
Sovie, Ronald J.
1988-01-01
As one looks to man's future in space it becomes obvious that unprecedented amounts of power are required for the exploration, colonization, and exploitation of space. Activities envisioned include interplanetary travel and LEO to GEO transport using electric propulsion, earth and lunar observatories, advance space stations, free-flying manufacturing platforms, communications platforms, and eventually evolutionary lunar and Mars bases. These latter bases would start as camps with modest power requirements (kWes) and evolve to large bases as manufacturing, food production, and life support materials are developed from lunar raw materials. These latter activities require very robust power supplies (MWes). The advanced power system technologies being pursued by NASA to fulfill these future needs are described. Technologies discussed will include nuclear, photovoltaic, and solar dynamic space power systems, including energy storage, power conditioning, power transmission, and thermal management. The state-of-the-art and gains to be made by technology advancements will be discussed. Mission requirements for a variety of applications (LEO, GEO, lunar, and Martian) will be treated, and data for power systems ranging from a few kilowatts to megawatt power systems will be represented. In addition the space power technologies being initiated under NASA's new Civilian Space Technology Initiative (CSTI) and Space Leadership Planning Group Activities will be discussed.
Connector Mechanism Has Smaller Stroke
NASA Technical Reports Server (NTRS)
Milam, M. Bruce
1992-01-01
System for connecting electrical and/or fluid lines includes mechanism reducing length of stroke necessary to make or break connections. Feature enables connection and disconnection in confined space, and compensates for misalignment between connectors. Connector in active member moves upward at twice the speed of downward stroke of passive member. Stroke amplified within connector system. Applications include connections between modular electronic units, coupled vehicles, and hydraulic systems.
ERIC Educational Resources Information Center
Stevens, Bette Le Feber
This booklet on the metric system and its presentation in the foreign language class has three main sections: (1) background material, including a brief history of the metric system and a rationale for teaching it in the foreign language class; (2) information for the teacher; and (3) learning activities. The second section includes terminology,…
78 FR 57455 - Pipeline Safety: Information Collection Activities
Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-18
... ``. . . system-specific information, including pipe diameter, operating pressure, product transported, and...) must provide contact information and geospatial data on their pipeline system. This information should... Mapping System (NPMS) to support various regulatory programs, pipeline inspections, and authorized...
Actively controlled vibration welding system and method
Cai, Wayne W.; Kang, Bongsu; Tan, Chin-An
2013-04-02
A vibration welding system includes a controller, welding horn, an active material element, and anvil assembly. The assembly may include an anvil body connected to a back plate and support member. The element, e.g., a piezoelectric stack or shape memory alloy, is positioned with respect to the assembly. The horn vibrates in a desirable first direction to form a weld on a work piece. The element controls any vibrations in a second direction by applying calibrated response to the anvil body in the second direction. A method for controlling undesirable vibrations in the system includes positioning the element with respect to the anvil assembly, connecting the anvil body to the support member through the back plate, vibrating the horn in a desirable first direction, and transmitting an input signal to the element to control vibration in an undesirable second direction.
NASA Technical Reports Server (NTRS)
Mickle, Marlin H. (Inventor); Jones, Alex K. (Inventor); Cain, James T. (Inventor); Hawrylak, Peter J. (Inventor); Marx, Frank (Inventor); Hoare, Raymond R. (Inventor)
2012-01-01
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an "always on" active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements in a sleep (standby) state, thus drastically extending battery life or other charge storage device life. Also, a wake-up solution that reduces total energy consumption of an active transponder system by allowing all non-addressed transponders to remain in a sleep (standby) state, thereby reducing total system or collection energy. Also, the transponder and wake-up solution are employed in an asset tracking system.
NASA Technical Reports Server (NTRS)
Mickle, Marlin H. (Inventor); Jones, Alex K. (Inventor); Cain, James T. (Inventor); Hawrylak, Peter J. (Inventor); Marx, Frank (Inventor); Hoare, Raymond R. (Inventor)
2011-01-01
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an "always on" active RF receiving element to anticipate a wake-up signal for the balance of the transponder electronics. This solution allows the entire active transponder to have all circuit elements in a sleep (standby) state, thus drastically extending battery life or other charge storage device life. Also, a wake-up solution that reduces total energy consumption of an active transponder system by allowing all non-addressed transponders to remain in a sleep (standby) state, thereby reducing total system or collection energy. Also, the transponder and wake-up solution are employed in an asset tracking system.
Active Transportation Surveillance - United States, 1999-2012.
Whitfield, Geoffrey P; Paul, Prabasaj; Wendel, Arthur M
2015-08-28
Physical activity is a health-enhancing behavior, and most U.S. adults do not meet the 2008 Physical Activity Guidelines for Americans. Active transportation, such as by walking or bicycling, is one way that persons can be physically active. No comprehensive, multiyear assessments of active transportation surveillance in the United States have been conducted. 1999-2012. Five surveillance systems assess one or more components of active transportation. The American Community Survey and the National Household Travel Survey (NHTS) both assess the mode of transportation to work in the past week. From these systems, the proportion of respondents who reported walking or bicycling to work can be calculated. NHTS and the American Time Use Survey include 1-day assessments of trips or activities. With that information, the proportion of respondents who report any walking or bicycling for transportation can be calculated. The National Health and Nutrition Examination Survey and the National Health Interview Survey both assess recent (i.e., in the past week or past month) habitual physical activity behaviors, including those performed during active travel. From these systems, the proportion of respondents who report any recent habitual active transportation can be calculated. The prevalence of active transportation as the primary commute mode to work in the past week ranged from 2.6% to 3.4%. The 1-day assessment indicated that the prevalence of any active transportation ranged from 10.5% to 18.5%. The prevalence of any habitual active transportation ranged from 23.9% to 31.4%. No consistent trends in active transportation across time periods and surveillance systems were identified. Among systems, active transportation was usually more common among men, younger respondents, and minority racial/ethnic groups. Among education groups, the highest prevalence of active transportation was usually among the least or most educated groups, and active transportation tended to be more prevalent in densely populated, urban areas. Active transportation is assessed in a wide variety of ways in multiple surveillance systems. Different assessment techniques and construct definitions result in widely discrepant estimates of active transportation; however, some consistent patterns were detected across covariates. Although each type of assessment (i.e., transportation to work, single day, and habitual behavior) measures a different active transportation component, all can be used to monitor population trends in active transportation participation. An understanding of the strengths, limitations, and lack of comparability of active transportation assessment techniques is necessary to correctly evaluate findings from the various surveillance systems. When used appropriately, these systems can be used by public health and transportation professionals to monitor population participation in active transportation and plan and evaluate interventions that influence active transportation.
An overview of current activities at the National Solar Thermal Test Facility
NASA Astrophysics Data System (ADS)
Cameron, C. P.; Klimas, P. C.
This paper is a description of the United States Department of Energy's National Solar Thermal Test Facility, highlighting current test programs. In the central receiver area, research underway supports commercialization of molten nitrate salt technology, including receivers, thermal energy transport, and corrosion experiments. Concentrator research includes large-area, glass-metal heliostats and stretched-membrane heliostats and dishes. Test activities in support of dish-Stirling systems with reflux receivers are described. Research on parabolic troughs includes characterization of several receiver configurations. Other test facility activities include solar detoxification experiments, design assistance testing of commercially-available solar hardware, and non-DOE-funded work, including thermal exposure tests and testing of volumetric and PV central receiver concepts.
Ruleman, Chester A.; Larsen, Mort; Stickney, Michael C.
2014-01-01
The catastrophic Hebgen Lake earthquake of 18 August 1959 (MW 7.3) led many geoscientists to develop new methods to better understand active tectonics in extensional tectonic regimes that address seismic hazards. The Madison Range fault system and adjacent Hebgen Lake–Red Canyon fault system provide an intermountain active tectonic analog for regional analyses of extensional crustal deformation. The Madison Range fault system comprises fault zones (~100 km in length) that have multiple salients and embayments marked by preexisting structures exposed in the footwall. Quaternary tectonic activity rates differ along the length of the fault system, with less displacement to the north. Within the Hebgen Lake basin, the 1959 earthquake is the latest slip event in the Hebgen Lake–Red Canyon fault system and southern Madison Range fault system. Geomorphic and paleoseismic investigations indicate previous faulting events on both fault systems. Surficial geologic mapping and historic seismicity support a coseismic structural linkage between the Madison Range and Hebgen Lake–Red Canyon fault systems. On this trip, we will look at Quaternary surface ruptures that characterize prehistoric earthquake magnitudes. The one-day field trip begins and ends in Bozeman, and includes an overview of the active tectonics within the Madison Valley and Hebgen Lake basin, southwestern Montana. We will also review geologic evidence, which includes new geologic maps and geomorphic analyses that demonstrate preexisting structural controls on surface rupture patterns along the Madison Range and Hebgen Lake–Red Canyon fault systems.
Knowledge system and method for simulating chemical controlled release device performance
Cowan, Christina E.; Van Voris, Peter; Streile, Gary P.; Cataldo, Dominic A.; Burton, Frederick G.
1991-01-01
A knowledge system for simulating the performance of a controlled release device is provided. The system includes an input device through which the user selectively inputs one or more data parameters. The data parameters comprise first parameters including device parameters, media parameters, active chemical parameters and device release rate; and second parameters including the minimum effective inhibition zone of the device and the effective lifetime of the device. The system also includes a judgemental knowledge base which includes logic for 1) determining at least one of the second parameters from the release rate and the first parameters and 2) determining at least one of the first parameters from the other of the first parameters and the second parameters. The system further includes a device for displaying the results of the determinations to the user.
Active Beam Shaping System and Method Using Sequential Deformable Mirrors
NASA Technical Reports Server (NTRS)
Pueyo, Laurent A. (Inventor); Norman, Colin A. (Inventor)
2015-01-01
An active optical beam shaping system includes a first deformable mirror arranged to at least partially intercept an entrance beam of light and to provide a first reflected beam of light, a second deformable mirror arranged to at least partially intercept the first reflected beam of light from the first deformable mirror and to provide a second reflected beam of light, and a signal processing and control system configured to communicate with the first and second deformable mirrors. The first deformable mirror, the second deformable mirror and the signal processing and control system together provide a large amplitude light modulation range to provide an actively shaped optical beam.
Solar Energy: Uses for Your Home. The CIRcular: Consumer Information Report 15.
ERIC Educational Resources Information Center
Bank of America NT & SA, San Francisco, CA.
This report defines active and passive solar energy systems, describes home uses for solar energy, and offers guidelines for choosing and installing a system. Much of the information is specific to the state of California. Uses for solar energy which are presented include passive space heating, passive cooling, active space heating, household…
Activated Biological Filters (ABF Towers). Student Manual. Biological Treatment Process Control.
ERIC Educational Resources Information Center
Wooley, John F.
This student manual contains textual material for a two-lesson unit on activated bio-filters (ABF). The first lesson (the sewage treatment plant) examines those process units that are unique to the ABF system. The lesson includes a review of the structural components of the ABF system and their functions and a discussion of several operational…
Elmarakeby, Haitham; Arefiyan, Mostafa; Myers, Elijah; Li, Song; Grene, Ruth; Heath, Lenwood S
2017-12-01
The Beacon Editor is a cross-platform desktop application for the creation and modification of signal transduction pathways using the Systems Biology Graphical Notation Activity Flow (SBGN-AF) language. Prompted by biologists' requests for enhancements, the Beacon Editor includes numerous powerful features for the benefit of creation and presentation.
ERIC Educational Resources Information Center
Wade, Meredith
This activity guide is based on the Public Broadcasting System's (PBS) program "ZOOM." It is designed for educators with activities that are categorized into three themes: (1) Things That Go, which includes "Air" which explores air pressure, "Rubber Bands" which discovers the potential energy of rubber bands,…
International Space Station Environmental Control and Life Support System Status: 2011-2012
NASA Technical Reports Server (NTRS)
Williams, David E.; Dake, Jason R.; Gentry, Gregory J.
2011-01-01
The International Space Station (ISS) Environmental Control and Life Support (ECLS) system includes regenerative and non-regenerative technologies that provide the basic life support functions to support the crew, while maintaining a safe and habitable shirtsleeve environment. This paper provides a summary of the U.S. ECLS system activities over the past year and the impacts of the international partners activities on them, covering the period of time between March 2011 and February 2012. The ISS continued permanent crew operations including the continuation of six crew members being on ISS. Work continues on the commercial cargo resupply vehicles, and work to try and extend ISS service life from 2015 to no later than 2028. 1
NASA Technical Reports Server (NTRS)
Williams, David E.; Gentry, Gregory J.
2015-01-01
The International Space Station (ISS) Environmental Control and Life Support (ECLS) system includes regenerative and non-regenerative technologies that provide the basic life support functions to support the crew, while maintaining a safe and habitable shirtsleeve environment. This paper provides a summary of the U.S. ECLS system activities over the past year and the impacts of the international partners' activities on them, covering the period of time between March 2013 and February 2014. The ISS continued permanent crew operations including the continuation of six crew members being on ISS. Work continues on the commercial crew vehicles, and work to try and extend ISS service life.
Skylab thruster attitude control system
NASA Technical Reports Server (NTRS)
Wilmer, G. E., Jr.
1974-01-01
Preflight activities and the Skylab mission support effort for the thruster attitude control system (TACS) are documented. The preflight activities include a description of problems and their solutions encountered in the development, qualification, and flight checkout test programs. Mission support effort is presented as it relates to system performance assessment, real-time problem solving, flight anomalies, and the daily system evaluation. Finally, the detailed flight evaluation is presented for each phase of the mission using system telemetry data. Data assert that the TACS met or exceeded design requirements and fulfilled its assigned mission objectives.
Space tracking and data systems; Proceedings of the Symposium, Arlington, VA, June 16-18, 1981
NASA Technical Reports Server (NTRS)
Grey, J. (Editor); Hamdan, L. A.
1981-01-01
The AIAA/NASA Symposium on Space Tracking and Data Systems, held in Pentagon City, Virginia, on June 16-18, 1981, had the purpose of reviewing international activities in space tracking and data systems for civil use in the 1980-2000 time frame. Participants included 225 representatives from industrial and government organizations in eight nations. The nations represented include the United States, France, Germany, India, Japan, Norway, Spain, and Sweden. The major functions of the systems described at the Symposium are related to the initial downlink of telemetry and spacecraft status data, attendant tracking activities, and uplink of spacecraft commands; communication between the associated acquisition sites and central processing and control stations; formulation and implementation of commands that control the spacecraft and its payload; and processing of spacecraft data needed to make command decisions. Attention is given to an overview of current activities and plans, and supporting developments, taking into account the time from 1980 to 1990. New developments are also considered.
Meyer, Johanna C.; Schellack, Natalie; Stokes, Jacobus; Lancaster, Ruth; Zeeman, Helecine; Defty, Douglas; Godman, Brian; Steel, Gavin
2017-01-01
Introduction: South Africa has an appreciable burden of both communicable and non-communicable diseases as well as high maternal, neonatal, and child morbidity. In recent years there have been significant strides with improving the public health system, and addressing current inequalities, with the right to health a constitutional provision in South Africa. Initiatives include the introduction of National Health Insurance, programmes to enhance access to medicines for patients with chronic diseases, as well as activities to improve care in hospitals, including improving pharmacovigilance. Consequently, the objective of this paper is to review ongoing initiatives within the public healthcare sector in South Africa and their influence to provide future direction. Method: Principally a structured review of current and planned activities. Results: There have been a number of major activities and initiatives surrounding the availability and access to medicines in the public system in recent years in South Africa. This includes a National Surveillance Centre and an innovative early warning system for the supply of medicines as well as the development of a National Health Care Pricing Authority and initiatives to improve contracting. There have also been developments to improve the supply chain including instigating Medicine Procurement Units in the provinces and enhancing forecasting capabilities. Access to medicines is improving though the instigation of stable chronic disease management initiatives to increase the number of external pick-up points for medicines. There are also ongoing programmes to enhance adherence to medicines as well as enhance adherence to the Standard Treatment Guidelines and the Essential Medicines List with their increasing availability. In addition, there is a movement to enhance the role of health technology assessment in future decision making. Hospital initiatives include increased focus on reducing antimicrobial resistance through instigating stewardship programmes as well as improving adverse drug reaction reporting and associated activities. Conclusion: Overall, there are an appreciable number of ongoing activities within the public healthcare system in South Africa attempting to ensure and sustain universal healthcare. It is too early to assess their impact, which will be the subject of future research. PMID:29163151
Meyer, Johanna C; Schellack, Natalie; Stokes, Jacobus; Lancaster, Ruth; Zeeman, Helecine; Defty, Douglas; Godman, Brian; Steel, Gavin
2017-01-01
Introduction: South Africa has an appreciable burden of both communicable and non-communicable diseases as well as high maternal, neonatal, and child morbidity. In recent years there have been significant strides with improving the public health system, and addressing current inequalities, with the right to health a constitutional provision in South Africa. Initiatives include the introduction of National Health Insurance, programmes to enhance access to medicines for patients with chronic diseases, as well as activities to improve care in hospitals, including improving pharmacovigilance. Consequently, the objective of this paper is to review ongoing initiatives within the public healthcare sector in South Africa and their influence to provide future direction. Method: Principally a structured review of current and planned activities. Results: There have been a number of major activities and initiatives surrounding the availability and access to medicines in the public system in recent years in South Africa. This includes a National Surveillance Centre and an innovative early warning system for the supply of medicines as well as the development of a National Health Care Pricing Authority and initiatives to improve contracting. There have also been developments to improve the supply chain including instigating Medicine Procurement Units in the provinces and enhancing forecasting capabilities. Access to medicines is improving though the instigation of stable chronic disease management initiatives to increase the number of external pick-up points for medicines. There are also ongoing programmes to enhance adherence to medicines as well as enhance adherence to the Standard Treatment Guidelines and the Essential Medicines List with their increasing availability. In addition, there is a movement to enhance the role of health technology assessment in future decision making. Hospital initiatives include increased focus on reducing antimicrobial resistance through instigating stewardship programmes as well as improving adverse drug reaction reporting and associated activities. Conclusion: Overall, there are an appreciable number of ongoing activities within the public healthcare system in South Africa attempting to ensure and sustain universal healthcare. It is too early to assess their impact, which will be the subject of future research.
VizieR Online Data Catalog: Chromospherically Active Binaries (Strassmeier+ 1993)
NASA Astrophysics Data System (ADS)
Strassmeier, K. G.; Hall, D. S.; Fekel, F. C.
1996-08-01
Stars always appear in order of increasing right-ascension for the epoch 2000.0. For the current version of the catalog, the literature was searched through December 31, 1991 although a few later references are included. Additionally, some entries are cited with "private communication", which make this catalog also a first-hand source. A number in parentheses behind an entry always corresponds to a reference given in the bibliography. See the 1988 publication for specific requirements and restrictions in compiling these catalogs. See the source reference for more details about this catalog. The following binary systems, which were listed in the first edition of the catalog, were not included in the present edition due to insufficient evidence for chromospheric activity: eta And 26 Aql 4 UMi nu2 Sgr tau Sgr the following stars are chromospherically active but are components in a "wide" binary and were not included. HD 25893 HD 79211 Forty three new binary systems have been included in the present edition. (12 data files).
Preliminary System Design of the SWRL Financial System.
ERIC Educational Resources Information Center
Ikeda, Masumi
The preliminary system design of the computer-based Southwest Regional Laboratory's (SWRL) Financial System is outlined. The system is designed to produce various management and accounting reports needed to maintain control of SWRL operational and financial activities. Included in the document are descriptions of the various types of system…
Mapping the petroleum system - An investigative technique to explore the hydrocarbon fluid system
Magoon, L.B.; Dow, W.G.
2000-01-01
Creating a petroleum system map includes a series of logical steps that require specific information to explain the origin in time and space of discovered hydrocarbon occurrences. If used creatively, this map provides a basis on which to develop complementary plays and prospects. The logical steps include the characterization of a petroleum system (that is, to identify, map, and name the hydrocarbon fluid system) and the summary of these results on a folio sheet. A petroleum system map is based on the understanding that there are several levels of certainty from "guessing" to "knowing" that specific oil and gas accumulations emanated from a particular pod of active source rock. Levels of certainty start with the close geographic proximity of two or more accumulations, continues with the close stratigraphic proximity, followed by the similarities in bulk properties, and then detailed geochemical properties. The highest level of certainty includes the positive geochemical correlation of the hydrocarbon fluid in the accumulations to the extract of the active source rock. A petroleum system map is created when the following logic is implemented. Implementation starts when the oil and gas accumulations of a petroleum province are grouped stratigraphically and geographically. Bulk and geochemical properties are used to further refine the groups through the determination of genetically related oil and gas types. To this basic map, surface seeps and well shows are added. Similarly, the active source rock responsible for these hydrocarbon occurrences are mapped to further define the extent of the system. A folio sheet constructed for a hypothetical case study of the Deer-Boar(.) petroleum system illustrates this methodology.
A "Kane's Dynamics" Model for the Active Rack Isolation System
NASA Astrophysics Data System (ADS)
Rupert, J. K.; Hampton, R. D.; Beech, G. S.
2005-02-01
In the late 1980s, microgravity researchers began to voice their concern that umbilical-transmitted energy could significantly degrade the acceleration environment of microgravity space science experiments onboard manned spacecraft. Since umbilicals are necessary for many experiments, control designers began to seek ways to compensate for these "indirect" disturbances. Hampton, et al., used the Kane s method to develop a model of the active rack isolation system (ARIS) that includes (1) actuator control forces, (2) direct disturbance forces, and (3) indirect, actuator-transmitted disturbances. Their model does not, however, include the indirect, umbilical-transmitted disturbances. Since the umbilical stiffnesses are not negligible, these indirect disturbances must be included in the model. Until the umbilicals have been appropriately included, the model will be incomplete. This Technical Memorandum presents a nonlinear model of ARIS with umbilicals included. Model verification was achieved by utilizing two commercial-off-the-shelf software tools. Various forces and moments were applied to the model to yield simulated responses of the system. Plots of the simulation results show how various critical points on an ARIS-outfitted international standard payload rack behave under the application of direct disturbances, indirect disturbances, and control forces. Simulations also show system response to a variety of initial conditions.
Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain
Olson, Keith M.; Lei, Wei; Keresztes, Attila; LaVigne, Justin; Streicher, John M.
2017-01-01
Opioid drugs like morphine and fentanyl are the gold standard for treating moderate to severe acute and chronic pain. However, opioid drug use can be limited by serious side effects, including constipation, tolerance, respiratory suppression, and addiction. For more than 100 years, we have tried to develop opioids that decrease or eliminate these liabilities, with little success. Recent advances in understanding opioid receptor signal transduction have suggested new possibilities to activate the opioid receptors to cause analgesia, while reducing or eliminating unwanted side effects. These new approaches include designing functionally selective ligands, which activate desired signaling cascades while avoiding signaling cascades that are thought to provoke side effects. It may also be possible to directly modulate downstream signaling through the use of selective activators and inhibitors. Separate from downstream signal transduction, it has also been found that when the opioid system is stimulated, various negative feedback systems are upregulated to compensate, which can drive side effects. This has led to the development of multi-functional molecules that simultaneously activate the opioid receptor while blocking various negative feedback receptor systems including cholecystokinin and neurokinin-1. Other novel approaches include targeting heterodimers of the opioid and other receptor systems which may drive side effects, and making endogenous opioid peptides druggable, which may also reduce opioid mediated side effects. Taken together, these advances in our molecular understanding provide a path forward to break the barrier in producing an opioid with reduced or eliminated side effects, especially addiction, which may provide relief for millions of patients. PMID:28356897
Marshall Space Flight Center ECLSS technology activities
NASA Technical Reports Server (NTRS)
Wieland, Paul
1990-01-01
Viewgraphs on Environmental Control and Life Support System (ECLSS) technology activities are presented. Topics covered include: analytical development; ECLSS modeling approach; example of water reclamation modeling needs; and hardware development and testing.
Integrated Flywheel Technology, 1983
NASA Technical Reports Server (NTRS)
Keckler, C. R. (Editor); Rodriguez, G. E. (Editor); Groom, N. J. (Editor)
1983-01-01
Topics of discussion included: technology assessment of the integrated flywheel systems, potential of system concepts, identification of critical areas needing development and, to scope and define an appropriate program for coordinated activity.
Energy systems research and development for petroleum refineries
DOE Office of Scientific and Technical Information (OSTI.GOV)
Robertson, J.L.
1982-08-01
For the past several years, Exxon Reasearch and Engineering has carried out a specific RandD program aimed at improving refinery energy efficiency through optimization of energy systems. Energy systems include: steam/power systems, heat exchange systems including hot oil and hot water belts and fuel systems, as well as some of the processes. This paper will describe the three major thrusts of this program which are: development of methods to support Site Energy Survey activities; development of energy management methods; and energy system optimization, which includes development of consistent, realistic, economic incentives for energy system improvements. Project selection criteria will alsomore » be discussed. The technique of a site energy survey will also be described briefly.« less
21 CFR 1300.01 - Definitions relating to controlled substances.
Code of Federal Regulations, 2012 CFR
2012-04-01
... substances having a depressant effect on the central nervous system, including its salts, isomers, and salts... paragraph. Automated dispensing system means a mechanical system that performs operations or activities... 1305.06. Readily retrievable means that certain records are kept by automatic data processing systems...
21 CFR 1300.01 - Definitions relating to controlled substances.
Code of Federal Regulations, 2013 CFR
2013-04-01
... substances having a depressant effect on the central nervous system, including its salts, isomers, and salts... paragraph. Automated dispensing system means a mechanical system that performs operations or activities... 1305.06. Readily retrievable means that certain records are kept by automatic data processing systems...
21 CFR 1300.01 - Definitions relating to controlled substances.
Code of Federal Regulations, 2014 CFR
2014-04-01
... substances having a depressant effect on the central nervous system, including its salts, isomers, and salts... paragraph. Automated dispensing system means a mechanical system that performs operations or activities... 1305.06. Readily retrievable means that certain records are kept by automatic data processing systems...
The anatomy and physiology of the locomotor system.
Farley, Alistair; McLafferty, Ella; Hendry, Charles
Mobilisation is one of the activities of living. The term locomotor system refers to those body tissues and organs responsible for movement. Nurses and healthcare workers should be familiar with the body structures that enable mobilisation to assist those in their care with this activity. This article outlines the structure and function of the locomotor system, including the skeleton, joints, muscles and muscle attachments. Two common bone disorders, osteoporosis and osteoarthritis, are also considered.
Space Transportation System Payloads Data and Analysis
NASA Technical Reports Server (NTRS)
Peterson, J. D.; Craft, H. G., Jr.
1975-01-01
The background, current developments and future plans for the Space Transportation System Payloads Data and Analysis (SPDA) activities at Marshall Space Flight Center are reviewed. It is shown how the payload data bank and future planned activities will interface with the payloads community and Space Transportation System designers. The interfaces with the STS data base include NASA planning, international planning, payload design, shuttle design, user agencies planning and information, and OMB, Congress and others.
Active coatings technologies for tailorable military coating systems
NASA Astrophysics Data System (ADS)
Zunino, J. L., III
2007-04-01
The main objective of the U.S. Army's Active Coatings Technologies Program is to develop technologies that can be used in combination to tailor coatings for utilization on Army Materiel. The Active Coatings Technologies Program, ACT, is divided into several thrusts, including the Smart Coatings Materiel Program, Munitions Coatings Technologies, Active Sensor packages, Systems Health Monitoring, Novel Technology Development, as well as other advanced technologies. The goal of the ACT Program is to conduct research leading to the development of multiple coatings systems for use on various military platforms, incorporating unique properties such as self repair, selective removal, corrosion resistance, sensing, ability to modify coatings' physical properties, colorizing, and alerting logistics staff when tanks or weaponry require more extensive repair. A partnership between the U.S. Army Corrosion Office at Picatinny Arsenal, NJ along with researchers at the New Jersey Institute of Technology, NJ, Clemson University, SC, University of New Hampshire, NH, and University of Massachusetts (Lowell), MA, are developing the next generation of Smart Coatings Materiel via novel technologies such as nanotechnology, Micro-electromechanical Systems (MEMS), meta-materials, flexible electronics, electrochromics, electroluminescence, etc. This paper will provide the reader with an overview of the Active Coatings Technologies Program, including an update of the on-going Smart Coatings Materiel Program, its progress thus far, description of the prototype Smart Coatings Systems and research tasks as well as future nanotechnology concepts, and applications for the Department of Defense.
NASA Technical Reports Server (NTRS)
Allard, Dan; Deforrest, Lloyd
2014-01-01
Flight software parameters enable space mission operators fine-tuned control over flight system configurations, enabling rapid and dynamic changes to ongoing science activities in a much more flexible manner than can be accomplished with (otherwise broadly used) configuration file based approaches. The Mars Science Laboratory (MSL), Curiosity, makes extensive use of parameters to support complex, daily activities via commanded changes to said parameters in memory. However, as the loss of Mars Global Surveyor (MGS) in 2006 demonstrated, flight system management by parameters brings with it risks, including the possibility of losing track of the flight system configuration and the threat of invalid command executions. To mitigate this risk a growing number of missions have funded efforts to implement parameter tracking parameter state software tools and services including MSL and the Soil Moisture Active Passive (SMAP) mission. This paper will discuss the engineering challenges and resulting software architecture of MSL's onboard parameter state tracking software and discuss the road forward to make parameter management tools suitable for use on multiple missions.
Code of Federal Regulations, 2010 CFR
2010-04-01
... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION THERMALLY PROCESSED LOW-ACID FOODS PACKAGED IN HERMETICALLY SEALED CONTAINERS General Provisions... systems and product formulating systems (including systems wherein water activity is used in conjunction...
systems, and international renewable energy activities including agriculture, forestry, bioenergy : Lead author of the Energy Systems Chapter and contributing author of the Agriculture, Forestry and , addressing climate change, sustainability certification of bioenergy and biomass, and integrated systems
NASA Technical Reports Server (NTRS)
1976-01-01
The engineering design for the Shuttle Missions Simulator is presented in sections, with each section representing a subsystem development activity. Subsystems covered include: electrical power system; mechanical power system; main propellant and external tank; solid rocket booster; reaction control system; orbital maneuvering system; guidance, navigation, and control; data processing system; mission control center interface; and image display system.
System of Systems Analytic Workbench - 2017
2017-08-31
and transitional activities with key collaborators. The tools include: System Operational Dependency Analysis/System Developmental Dependency Analysis...in the methods of the SoS-AWB involve the following: 1. System Operability Dependency Analysis (SODA)/System Development Dependency Analysis...available f. Development of standard dependencies with combinations of low-medium-high parameters Report No. SERC-2017-TR-111
Detection of Cardiopulmonary Activity and Related Abnormal Events Using Microsoft Kinect Sensor.
Al-Naji, Ali; Chahl, Javaan
2018-03-20
Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not. The proposed system extracts the signal from the abdominal-thoracic region where cardiopulmonary activity is most pronounced, using a real-time image sequence captured by Kinect v2 sensor. The proposed system shows promising results in any sleep posture, regardless of illumination conditions and unclear ROI even in the presence of a blanket, whilst being reliable, safe, and cost-effective.
Detection of Cardiopulmonary Activity and Related Abnormal Events Using Microsoft Kinect Sensor
Chahl, Javaan
2018-01-01
Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not. The proposed system extracts the signal from the abdominal-thoracic region where cardiopulmonary activity is most pronounced, using a real-time image sequence captured by Kinect v2 sensor. The proposed system shows promising results in any sleep posture, regardless of illumination conditions and unclear ROI even in the presence of a blanket, whilst being reliable, safe, and cost-effective. PMID:29558414
Singh, Gurpreet; Ravi, Koustuban; Wang, Qian; Ho, Seng-Tiong
2012-06-15
A complex-envelope (CE) alternating-direction-implicit (ADI) finite-difference time-domain (FDTD) approach to treat light-matter interaction self-consistently with electromagnetic field evolution for efficient simulations of active photonic devices is presented for the first time (to our best knowledge). The active medium (AM) is modeled using an efficient multilevel system of carrier rate equations to yield the correct carrier distributions, suitable for modeling semiconductor/solid-state media accurately. To include the AM in the CE-ADI-FDTD method, a first-order differential system involving CE fields in the AM is first set up. The system matrix that includes AM parameters is then split into two time-dependent submatrices that are then used in an efficient ADI splitting formula. The proposed CE-ADI-FDTD approach with AM takes 22% of the time as the approach of the corresponding explicit FDTD, as validated by semiconductor microdisk laser simulations.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jackson, K.A.; Neuman, M.C.; Simmonds, D.D.
An effective method for detecting computer misuse is the automatic monitoring and analysis of on-line user activity. This activity is reflected in the system audit record, in the system vulnerability posture, and in other evidence found through active testing of the system. During the last several years we have implemented an automatic misuse detection system at Los Alamos. This is the Network Anomaly Detection and Intrusion Reporter (NADIR). We are currently expanding NADIR to include processing of the Cray UNICOS operating system. This new component is called the UNICOS Realtime NADIR, or UNICORN. UNICORN summarizes user activity and system configurationmore » in statistical profiles. It compares these profiles to expert rules that define security policy and improper or suspicious behavior. It reports suspicious behavior to security auditors and provides tools to aid in follow-up investigations. The first phase of UNICORN development is nearing completion, and will be operational in late 1994.« less
Saby, Emilie; Poulsen, Jesper Buchhave; Justesen, Just; Kelve, Merike; Uriz, Maria Jesus
2009-01-01
Sponges [porifera], the most ancient metazoans, contain modules related to the vertebrate immune system, including the 2',5'-oligoadenylate synthetase (OAS). The components of the antiviral 2',5'-oligoadenylate (2-5A) system (OAS, 2'-Phosphodiesterase (2'-PDE) and RNAse L) of vertebrates have not all been identified in sponges. Here, we demonstrate for the first time that in addition to the OAS activity, sponges possess a 2'-PDE activity, which highlights the probable existence of a premature 2-5A system. Indeed, Suberites domuncula and Crella elegans exhibited this 2-5A degrading activity. Upon this finding, two out of three elements forming the 2-5A system have been found in sponges, only a endoribonuclease, RNAse L or similar, has to be found. We suspect the existence of a complex immune system in sponges, besides the self/non-self recognition system and the use of phagocytosis and secondary metabolites against pathogens.
Involvement of autophagy in T cell biology.
Oral, Ozlem; Yedier, Ozlem; Kilic, Seval; Gozuacik, Devrim
2017-01-01
Autophagy is an essential cellular pathway that sequesters various cytoplasmic components, including accumulated proteins, damaged organelles or invading microorganisms and delivers them to lysosomes for degradation. The function of autophagy has been reported in various tissues and systems, including its role in the regulation of cellular immunity. Autophagy plays a fundamental role at various stages of T cell maturation. It regulates the thymocyte selection and the generation of T cell repertoire by presenting intracellular antigens to MHC class molecules. Autophagy is crucial for metabolic regulation of T cells, and therefore supports cell survival and homeostasis, particularly in activated mature T cells. Furthermore, deletion of specific autophagy-related genes induces several immunological alterations including differentiation of activated T cells into regulatory, memory or natural killer T cells. In this review, we emphasize the impact of autophagy on T cell development, activation and differentiation, which is pivotal for the adaptive immune system.
Organic farming enhances soil microbial abundance and activity—A meta-analysis and meta-regression
Symnaczik, Sarah; Mäder, Paul; De Deyn, Gerlinde; Gattinger, Andreas
2017-01-01
Population growth and climate change challenge our food and farming systems and provide arguments for an increased intensification of agriculture. A promising option is eco-functional intensification through organic farming, an approach based on using and enhancing internal natural resources and processes to secure and improve agricultural productivity, while minimizing negative environmental impacts. In this concept an active soil microbiota plays an important role for various soil based ecosystem services such as nutrient cycling, erosion control and pest and disease regulation. Several studies have reported a positive effect of organic farming on soil health and quality including microbial community traits. However, so far no systematic quantification of whether organic farming systems comprise larger and more active soil microbial communities compared to conventional farming systems was performed on a global scale. Therefore, we conducted a meta-analysis on current literature to quantify possible differences in key indicators for soil microbial abundance and activity in organic and conventional cropping systems. All together we integrated data from 56 mainly peer-reviewed papers into our analysis, including 149 pairwise comparisons originating from different climatic zones and experimental duration ranging from 3 to more than 100 years. Overall, we found that organic systems had 32% to 84% greater microbial biomass carbon, microbial biomass nitrogen, total phospholipid fatty-acids, and dehydrogenase, urease and protease activities than conventional systems. Exclusively the metabolic quotient as an indicator for stresses on microbial communities remained unaffected by the farming systems. Categorical subgroup analysis revealed that crop rotation, the inclusion of legumes in the crop rotation and organic inputs are important farming practices affecting soil microbial community size and activity. Furthermore, we show that differences in microbial size and activity between organic and conventional farming systems vary as a function of land use (arable, orchards, and grassland), plant life cycle (annual and perennial) and climatic zone. In summary, this study shows that overall organic farming enhances total microbial abundance and activity in agricultural soils on a global scale. PMID:28700609
Coady, Katherine K.; Biever, Ronald C.; Denslow, Nancy D.; Gross, Melanie; Guiney, Patrick D.; Holbech, Henrik; Karouna-Renier, Natalie K.; Katsiadaki, Ioanna; Krueger, Hank; Levine, Steven L.; Maack, Gerd; Williams, Mike; Wolf, Jeffrey C.; Ankley, Gerald T.
2017-01-01
In the present study, existing regulatory frameworks and test systems for assessing potential endocrine active chemicals are described, and associated challenges are discussed, along with proposed approaches to address these challenges. Regulatory frameworks vary somewhat across geographies, but all basically evaluate whether a chemical possesses endocrine activity and whether this activity can result in adverse outcomes either to humans or to the environment. Current test systems include in silico, in vitro, and in vivo techniques focused on detecting potential endocrine activity, and in vivo tests that collect apical data to detect possible adverse effects. These test systems are currently designed to robustly assess endocrine activity and/or adverse effects in the estrogen, androgen, and thyroid hormone signaling pathways; however, there are some limitations of current test systems for evaluating endocrine hazard and risk. These limitations include a lack of certainty regarding: 1) adequately sensitive species and life stages; 2) mechanistic endpoints that are diagnostic for endocrine pathways of concern; and 3) the linkage between mechanistic responses and apical, adverse outcomes. Furthermore, some existing test methods are resource intensive with regard to time, cost, and use of animals. However, based on recent experiences, there are opportunities to improve approaches to and guidance for existing test methods and to reduce uncertainty. For example, in vitro high-throughput screening could be used to prioritize chemicals for testing and provide insights as to the most appropriate assays for characterizing hazard and risk. Other recommendations include adding endpoints for elucidating connections between mechanistic effects and adverse outcomes, identifying potentially sensitive taxa for which test methods currently do not exist, and addressing key endocrine pathways of possible concern in addition to those associated with estrogen, androgen, and thyroid signaling.
INTEGRATED TAXONOMIC INFORMATION SYSTEM (ITIS) - BACILLARIOPHYTA
Access to consistent, scientifically credible taxomonic information is essential to many governmental activities. These activities include natural resource management for sustained use, land owner assistance, environmental regulation, and biotechnology development. As part of the...
12 CFR 9.9 - Audit of fiduciary activities.
Code of Federal Regulations, 2010 CFR
2010-01-01
... discrete audit (by internal or external auditors) of each significant fiduciary activity (i.e., on an... system shall note the results of all discrete audits performed since the last audit report (including...
Astronomy: Project Earth Science.
ERIC Educational Resources Information Center
Smith, P. Sean
This book presents classroom activities and reading materials. The activities use a hands-on approach and address the standards. Each features both a student section and a teacher guide. Eleven activities include: (1) "It's Only a Paper Moon"; (2) "Time Traveler"; (3) "Solar System Scale"; (4) "Hello Out…
Teacher's Psycho-Diagnostic Activities in School Educational System
ERIC Educational Resources Information Center
Minakhmetova, Albina Z.; Pyanova, Ekaterina N.; Akhmetshina, Enze M.
2016-01-01
The urgency of the problem stated in the article stems from the fact that in modern conditions the study of the psycho-diagnostic component of the teacher's activities is relevant in practical terms, since the functions of these activities affect the efficiency of pedagogical activity and the educational process itself, including the effectiveness…
Novak, Colleen M; Burghardt, Paul R; Levine, James A
2012-03-01
Running wheels are commonly employed to measure rodent physical activity in a variety of contexts, including studies of energy balance and obesity. There is no consensus on the nature of wheel-running activity or its underlying causes, however. Here, we will begin by systematically reviewing how running wheel availability affects physical activity and other aspects of energy balance in laboratory rodents. While wheel running and physical activity in the absence of a wheel commonly correlate in a general sense, in many specific aspects the two do not correspond. In fact, the presence of running wheels alters several aspects of energy balance, including body weight and composition, food intake, and energy expenditure of activity. We contend that wheel-running activity should be considered a behavior in and of itself, reflecting several underlying behavioral processes in addition to a rodent's general, spontaneous activity. These behavioral processes include defensive behavior, predatory aggression, and depression- and anxiety-like behaviors. As it relates to energy balance, wheel running engages several brain systems-including those related to the stress response, mood, and reward, and those responsive to growth factors-that influence energy balance indirectly. We contend that wheel-running behavior represents factors in addition to rodents' tendency to be physically active, engaging additional neural and physiological mechanisms which can then independently alter energy balance and behavior. Given the impact of wheel-running behavior on numerous overlapping systems that influence behavior and physiology, this review outlines the need for careful design and interpretation of studies that utilize running wheels as a means for exercise or as a measurement of general physical activity. Copyright © 2012 Elsevier Ltd. All rights reserved.
Current limitations and recommendations to improve testing ...
In this paper existing regulatory frameworks and test systems for assessing potential endocrine-active chemicals are described, and associated challenges discussed, along with proposed approaches to address these challenges. Regulatory frameworks vary somewhat across organizations, but all basically evaluate whether a chemical possesses endocrine activity and whether this activity can result in adverse outcomes either to humans or the environment. Current test systems include in silico, in vitro and in vivo techniques focused on detecting potential endocrine activity, and in vivo tests that collect apical data to detect possible adverse effects. These test systems are currently designed to robustly assess endocrine activity and/or adverse effects in the estrogen, androgen, and thyroid hormonal pathways; however, there are some limitations of current test systems for evaluating endocrine hazard and risk. These limitations include a lack of certainty regarding: 1)adequately sensitive species and life-stages, 2) mechanistic endpoints that are diagnostic for endocrine pathways of concern, and 3) the linkage between mechanistic responses and apical, adverse outcomes. Furthermore, some existing test methods are resource intensive in regard to time, cost, and use of animals. However, based on recent experiences, there are opportunities to improve approaches to, and guidance for existing test methods, and to reduce uncertainty. For example, in vitro high throughput
Administrative Information Systems Plan for FY89
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1988-11-01
The Administrative Information Systems (AIS) Plan was developed to prioritize, track, and control the cost of AIS activities. This annually published plan, in conjunction with quarterly status reports, measures projected AIS activities and progress. The AIS Plan and quarterly reporting are administered jointly by the Director of Computing and an Organization 30 director. Priority development projects are clearly defined and closely managed efforts that consume significant resources. Directorate supplementals describe other AIS activity within each directorate, which may include: production support; technical support; development activity; and other AIS effort.
Development of Integrated Information System for Travel Bureau Company
NASA Astrophysics Data System (ADS)
Karma, I. G. M.; Susanti, J.
2018-01-01
Related to the effectiveness of decision-making by the management of travel bureau company, especially by managers, information serves frequent delays or incomplete. Although already computer-assisted, the existing application-based is used only handle one particular activity only, not integrated. This research is intended to produce an integrated information system that handles the overall operational activities of the company. By applying the object-oriented system development approach, the system is built with Visual Basic. Net programming language and MySQL database package. The result is a system that consists of 4 (four) separated program packages, including Reservation System, AR System, AP System and Accounting System. Based on the output, we can conclude that this system is able to produce integrated information that related to the problem of reservation, operational and financial those produce up-to-date information in order to support operational activities and decisionmaking process by related parties.
Lunar base thermal management/power system analysis and design
NASA Technical Reports Server (NTRS)
Mcghee, Jerry R.
1992-01-01
A compilation of several lunar surface thermal management and power system studies completed under contract and IR&D is presented. The work includes analysis and preliminary design of all major components of an integrated thermal management system, including loads determination, active internal acquisition and transport equipment, external transport systems (active and passive), passive insulation, solar shielding, and a range of lunar surface radiator concepts. Several computer codes were utilized in support of this study, including RADSIM to calculate radiation exchange factors and view factors, RADIATOR (developed in-house) for heat rejection system sizing and performance analysis over a lunar day, SURPWER for power system sizing, and CRYSTORE for cryogenic system performance predictions. Although much of the work was performed in support of lunar rover studies, any or all of the results can be applied to a range of surface applications. Output data include thermal loads summaries, subsystem performance data, mass, and volume estimates (where applicable), integrated and worst-case lunar day radiator size/mass and effective sink temperatures for several concepts (shielded and unshielded), and external transport system performance estimates for both single and two-phase (heat pumped) transport loops. Several advanced radiator concepts are presented, along with brief assessments of possible system benefits and potential drawbacks. System point designs are presented for several cases, executed in support of the contract and IR&D studies, although the parametric nature of the analysis is stressed to illustrate applicability of the analysis procedure to a wide variety of lunar surface systems. The reference configuration(s) derived from the various studies will be presented along with supporting criteria. A preliminary design will also be presented for the reference basing scenario, including qualitative data regarding TPS concerns and issues.
Why differentiating between health system support and health system strengthening is needed
Chee, Grace; Pielemeier, Nancy; Lion, Ann; Connor, Catherine
2013-01-01
There is increasing recognition that efforts to improve global health cannot be achieved without stronger health systems. Interpretation of health system strengthening (HSS) has varied widely however, with much of the focus to-date on alleviating input constraints, whereas less attention has been given to other performance drivers. It is important to distinguish activities that support the health system, from ones that strengthen the health system. Supporting the health system can include any activity that improves services, from distributing mosquito nets to procuring medicines. These activities improve outcomes primarily by increasing inputs. Strengthening the health system is accomplished by more comprehensive changes to performance drivers such as policies and regulations, organizational structures, and relationships across the health system to motivate changes in behavior and/or allow more effective use of resources to improve multiple health services. Even organizations that have made significant investments in health systems have not provided guidance on what HSS entails. While both supporting and strengthening are important and necessary, it is nonetheless important to make a distinction. If activities fail to produce improvements in system performance because they were incorrectly labeled as system strengthening, the value of HSS investments could quickly be discredited. Not distinguishing supportive activities from strengthening ones will lead to unmet expectations of stronger health systems, as well as neglect of critical system strengthening activities. Distinguishing between these two types of activities will improve programming impact. Copyright © 2012 John Wiley & Sons, Ltd. PMID:22777839
Apparatus for in situ cleaning of carbon contaminated surfaces
Klebanoff, Leonard E.; Grunow, Philip; Graham, Jr., Samuel
2004-08-10
Activated gaseous species generated adjacent a carbon contaminated surface affords in-situ cleaning. A device for removing carbon contamination from a surface of the substrate includes (a) a housing defining a vacuum chamber in which the substrate is located; (b) a source of gaseous species; and (c) a source of electrons that are emitted to activate the gaseous species into activated gaseous species. The source of electrons preferably includes (i) a filament made of a material that generates thermionic electron emissions; (ii) a source of energy that is connected to the filament; and (iii) an electrode to which the emitted electrons are attracted. The device is particularly suited for photolithography systems with optic surfaces, e.g., mirrors, that are otherwise inaccessible unless the system is dismantled.
Kirino, Masato; Parnes, Jason; Hansen, Anne; Kiyohara, Sadao; Finger, Thomas E.
2013-01-01
Taste buds are gustatory endorgans which use an uncommon purinergic signalling system to transmit information to afferent gustatory nerve fibres. In mammals, ATP is a crucial neurotransmitter released by the taste cells to activate the afferent nerve fibres. Taste buds in mammals display a characteristic, highly specific ecto-ATPase (NTPDase2) activity, suggesting a role in inactivation of the neurotransmitter. The purpose of this study was to test whether the presence of markers of purinergic signalling characterize taste buds in anamniote vertebrates and to test whether similar purinergic systems are employed by other exteroceptive chemosensory systems. The species examined include several teleosts, elasmobranchs, lampreys and hagfish, the last of which lacks vertebrate-type taste buds. For comparison, Schreiner organs of hagfish and solitary chemosensory cells (SCCs) of teleosts, both of which are epidermal chemosensory end organs, were also examined because they might be evolutionarily related to taste buds. Ecto-ATPase activity was evident in elongate cells in all fish taste buds, including teleosts, elasmobranchs and lampreys. Neither SCCs nor Schreiner organs show specific ecto-ATPase activity, suggesting that purinergic signalling is not crucial in those systems as it is for taste buds. These findings suggest that the taste system did not originate from SCCs but arose independently in early vertebrates. PMID:23466675
Kirino, Masato; Parnes, Jason; Hansen, Anne; Kiyohara, Sadao; Finger, Thomas E
2013-03-06
Taste buds are gustatory endorgans which use an uncommon purinergic signalling system to transmit information to afferent gustatory nerve fibres. In mammals, ATP is a crucial neurotransmitter released by the taste cells to activate the afferent nerve fibres. Taste buds in mammals display a characteristic, highly specific ecto-ATPase (NTPDase2) activity, suggesting a role in inactivation of the neurotransmitter. The purpose of this study was to test whether the presence of markers of purinergic signalling characterize taste buds in anamniote vertebrates and to test whether similar purinergic systems are employed by other exteroceptive chemosensory systems. The species examined include several teleosts, elasmobranchs, lampreys and hagfish, the last of which lacks vertebrate-type taste buds. For comparison, Schreiner organs of hagfish and solitary chemosensory cells (SCCs) of teleosts, both of which are epidermal chemosensory end organs, were also examined because they might be evolutionarily related to taste buds. Ecto-ATPase activity was evident in elongate cells in all fish taste buds, including teleosts, elasmobranchs and lampreys. Neither SCCs nor Schreiner organs show specific ecto-ATPase activity, suggesting that purinergic signalling is not crucial in those systems as it is for taste buds. These findings suggest that the taste system did not originate from SCCs but arose independently in early vertebrates.
ERIC Educational Resources Information Center
Bilal, Dania; Barry, Jeff; Penniman, W. David
1999-01-01
Reviews automated-systems activities in libraries during the past year and profiles major vendors. Topics include new partnership arrangements driven by competition; library-systems revenues; Y2K issues; Windows-based interfaces; consulting; outsourcing; development trends; global system sales; and sales by type of library. (LRW)
Lazar, Amanda; Demiris, George; Thompson, Hilaire J
2016-12-01
Stimulating recreational and leisure activities (RLAs) are essential to physical and mental well-being; however, people living in memory care units (MCUs) may lack access to them. Technology has the potential to facilitate and enrich activity engagement in this context. In this 6-month study, we evaluated a commercially available system designed to encourage the engagement of people with dementia in activities and social interactions, using a mixed-methods approach in a MCU. Quantitative measures included those to evaluate cognition, depression, quality of life, and resource utilization. We qualitatively evaluated the system using semi-structured interviews with family members and staff. Five residents with dementia, four family members, and seven staff were included in the 6-month study. Staff and family members reported benefits for residents such as enjoyment, interactions and connections with others, and mental stimulation. Findings also highlight challenges such as technical and ethical concerns. Factors that influence system use and integration are also discussed. It was feasible to introduce a system designed for recreation and engagement in a MCU, and staff, family members, and residents experienced benefits. However, barriers existed in the introduction and use of the system.
Propulsion Controls and Diagnostics Research at NASA Glenn Research Center
NASA Technical Reports Server (NTRS)
Garg, Sanjay
2007-01-01
With the increased emphasis on aircraft safety, enhanced performance and affordability, and the need to reduce the environmental impact of aircraft, there are many new challenges being faced by the designers of aircraft propulsion systems. Also the propulsion systems required to enable the National Aeronautics and Space Administration (NASA) Vision for Space Exploration in an affordable manner will need to have high reliability, safety and autonomous operation capability. The Controls and Dynamics Branch (CDB) at NASA Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet these challenges through the concept of Intelligent Propulsion Systems. This paper describes the current activities of the CDB under the NASA Aeronautics Research and Exploration Systems Missions. The programmatic structure of the CDB activities is described along with a brief overview of each of the CDB tasks including research objectives, technical challenges, and recent accomplishments. These tasks include active control of propulsion system components, intelligent propulsion diagnostics and control for reliable fault identification and accommodation, distributed engine control, and investigations into unsteady propulsion systems.
Expert system for on-board satellite scheduling and control
NASA Technical Reports Server (NTRS)
Barry, John M.; Sary, Charisse
1988-01-01
An Expert System is described which Rockwell Satellite and Space Electronics Division (S&SED) is developing to dynamically schedule the allocation of on-board satellite resources and activities. This expert system is the Satellite Controller. The resources to be scheduled include power, propellant and recording tape. The activities controlled include scheduling satellite functions such as sensor checkout and operation. The scheduling of these resources and activities is presently a labor intensive and time consuming ground operations task. Developing a schedule requires extensive knowledge of the system and subsystems operations, operational constraints, and satellite design and configuration. This scheduling process requires highly trained experts anywhere from several hours to several weeks to accomplish. The process is done through brute force, that is examining cryptic mnemonic data off line to interpret the health and status of the satellite. Then schedules are formulated either as the result of practical operator experience or heuristics - that is rules of thumb. Orbital operations must become more productive in the future to reduce life cycle costs and decrease dependence on ground control. This reduction is required to increase autonomy and survivability of future systems. The design of future satellites require that the scheduling function be transferred from ground to on board systems.
Lazar, Amanda; Demiris, George; Thompson, Hilaire J.
2016-01-01
Introduction Stimulating recreational and leisure activities (RLAs) are essential to physical and mental well-being; however, people living in memory care units (MCUs) may lack access to them. Technology has the potential to facilitate and enrich activity engagement in this context. Objectives In this 6-month study, we evaluated a commercially available system designed to encourage the engagement of people with dementia in activities and social interactions, using a mixed-methods approach in a MCU. Methods Quantitative measures included those to evaluate cognition, depression, quality of life, and resource utilization. We qualitatively evaluated the system using semi-structured interviews with family members and staff. Five residents with dementia, four family members, and seven staff were included in the 6-month study. Results Staff and family members reported benefits for residents such as enjoyment, interactions and connections with others, and mental stimulation. Findings also highlight challenges such as technical and ethical concerns. Factors that influence system use and integration are also discussed. Conclusion It was feasible to introduce a system designed for recreation and engagement in a MCU, and staff, family members, and residents experienced benefits. However, barriers existed in the introduction and use of the system. PMID:26819070
System Engineering Analysis For Improved Scout Business Information Systems
DOE Office of Scientific and Technical Information (OSTI.GOV)
Van Slyke, D. A.
The project uses system engineering principles to address the need of Boy Scout leaders for an integrated system to facilitate advancement and awards records, leader training and planning for meetings and activities. Existing products to address needs of Scout leaders and relevant stakeholders function to support record keeping and some communication functions but opportunity exists for a better system to fully integrate these functions with training delivery and recording, activity planning along with feedback and information gathering from stakeholders. Key stakeholders for the sytem include Scouts and their families, leaders, training providers, sellers of supplies and awards, content generators andmore » facilities that serve Scout activities. Key performance parameters for the system are protection of personal information, availability of current information, information accuracy and information content that has depth. Implementation concepts considered for the system include (1) owned and operated by Boy Scouts of America, (2) Contracted out to a vendor (3) distributed system that functions with BSA managed interfaces. The selected concept is to contract out to a vendor to maximize the likelihood of successful integration and take advantage of the best technology. Development of requirements considers three key use cases (1) System facilitates planning a hike with training needed satisfied in advance and advancement recording real time (2) Scheduling and documenting in-person training, (3) Family interested in Scouting receives information and can request follow-up. Non-functional requirements are analyzed with the Quality Function Deployment tool. Requirement addressing frequency of backup, compatibility with legacy and new technology, language support, software update are developed to address system reliability and intuitive interface. System functions analyzed include update of activity database, maintenance of advancement status, archive of documents, and monitoring of content that is accessible. The study examines risks associated with information security, technological change and continued popularity of Scouting. Mitigation is based on system functions that are defined. The approach to developing an improved system for facilitating Boy Scout leader functions was iterative with insights into capabilities coming in the course of working through the used cases and sequence diagrams.« less
Flutter suppression and gust alleviation using active controls
NASA Technical Reports Server (NTRS)
Nissim, E.
1974-01-01
The effects of active controls on the suppression of flutter and gust alleviation of two different types of subsonic aircraft (the Arava, twin turboprop STOL transport, and the Westwind twin-jet business transport) are investigated. The active controls are introduced in pairs which include, in any chosen wing strip, a leading-edge (LE) control and a trailing-edge (TE) control. Each control surface is allowed to be driven by a combined linear-rotational sensor system, located on the activated strip. The control law, which translates the sensor signals into control surface rotations, is based on the concept of aerodynamic energy. The results indicate the extreme effectiveness of the active systems in controlling flutter. A single system spanning 10% of the wing semispan made the Arava flutter-free, and a similar active system, for the Westwind aircraft, yielded a reduction of 75% in the maximum bending moment of the wing and a reduction of 90% in the acceleration of the cg of the aircraft. Results for simultaneous activation of several LE - TE systems are presented. Further work needed to bring the investigation to completion is also discussed.
Solar Water Heater Systems for Building Trades Class.
ERIC Educational Resources Information Center
Ryan, Milton; And Others
This teaching unit serves as a guide for the installation of active solar water heating systems. It contains a project designed for use with secondary level students of a building trades class. Students typically would meet 2 to 3 hours per day and would be able to complete the activity within a 1-week time period. Objectives of this unit include:…
Parabolic Dish Solar Thermal Power Annual Program Review Proceedings
NASA Technical Reports Server (NTRS)
Lucas, J. W.
1982-01-01
The results of activities of the parabolic dish technology and applications development element of DOE's Solar Thermal Energy System Program are presented. Topics include the development and testing of concentrators, receivers, and power conversion units; system design and development for engineering experiments; economic analysis and marketing assessment; and advanced development activities. A panel discussion concerning industrial support sector requirements is also documented.
ERIC Educational Resources Information Center
Cloonan, Carrie A.; Andrew, Julie A.; Nichol, Carolyn A.; Hutchinson, John S.
2011-01-01
This article describes an activity that can be used as an inquiry-based laboratory or demonstration for either high school or undergraduate chemistry students to provide a basis for understanding both vapor pressure and the concept of dynamic phase equilibrium. The activity includes a simple setup to create a closed system of only water liquid and…
Breaking BAD: A Data Serving Vision for Big Active Data
Carey, Michael J.; Jacobs, Steven; Tsotras, Vassilis J.
2017-01-01
Virtually all of today’s Big Data systems are passive in nature. Here we describe a project to shift Big Data platforms from passive to active. We detail a vision for a scalable system that can continuously and reliably capture Big Data to enable timely and automatic delivery of new information to a large pool of interested users as well as supporting analyses of historical information. We are currently building a Big Active Data (BAD) system by extending an existing scalable open-source BDMS (AsterixDB) in this active direction. This first paper zooms in on the Data Serving piece of the BAD puzzle, including its key concepts and user model. PMID:29034377
In-Vitro Induced Immunosuppression in a Rotary Cell Culture System
NASA Technical Reports Server (NTRS)
Grimm, Elizabeth A.
1998-01-01
The function of the innate immune system is to provide a first-line of defense against infectious organisms, via control of bacterial and viral growth using antigen nonspecific means. These nonspecific immune effectors include macrophages and Natural Killing (NK) cells, and certain cytokines elicited in response to "super antigens" on the infectious agents. This innate system usually keeps most infectious agents from rapidly growing while the adaptive immune system is generating a specific response complete with immunologic memory. Compelling evidence suggests that space flight results in various immunosuppressive effects, including reduced innate and adaptive immune responses. We were particularly concerned with reduced NK activity at landing, and have asked whether the microgravity component of space flight could be responsible for the previously observed NK defect. We have conclusively demonstrated that simulated microgravity as provided by the Synthecon bioreactors does not inhibit the NK function nor the IL-2 activation of lymphokine-activated killing (LAK). Interleukin-2 is the key cytokine responsible for activation of NK cells to express LAK, as well as to support differentiation of lymphocytes during adaptive immune responses. Therefore, we have disproved our original hypothesis based on poor NK in many of the astronauts upon landing.
The Telecommunications and Data Acquisition Report
NASA Technical Reports Server (NTRS)
Yuen, Joseph H. (Editor)
1993-01-01
This quarterly publication provides archival reports on developments in programs managed by JPL's Office of Telecommunications and Data Acquisition (TDA). In space communications, radio navigation, radio science, and ground-based radio and radar astronomy, it reports on activities of the Deep Space Network (DSN) in planning, supporting research and technology, implementation, and operations. Also included are standards activity at JPL for space data and information systems and reimbursable DSN work performed for other space agencies through NASA. The papers included in this document cover satellite tracking and ground-based navigation, spacecraft-ground communications, and optical communication systems for the Deep Space Network.
Elementary school aerospace activities: A resource for teachers
NASA Technical Reports Server (NTRS)
1977-01-01
The chronological development of the story of man and flight, with emphasis on space flight, is presented in 10 units designed as a resource for elementary school teachers. Future exploration of space and the utlization of space flight capabilities are included. Each unit contains an outline, a list of suggested activities for correlation, a bibliography, and a list of selected audiovisual materials. A glossary of aerospace terms is included. Topics cover: earth characteristics that affect flight; flight in atmosphere, rockets, technological advances, unmanned Earth satellites, umanned exploration of the solar system, life support systems; astronauts, man in space, and projections for the future.
NASA Technical Reports Server (NTRS)
Engelund, Walter C.; Holland, Scott D.; Cockrell, Charles E., Jr.; Bittner, Robert D.
1999-01-01
NASA's Hyper-X Research Vehicle will provide a unique opportunity to obtain data on an operational airframe integrated scramjet propulsion system at true flight conditions. The airframe integrated nature of the scramjet engine with the Hyper-X vehicle results in a strong coupling effect between the propulsion system operation and the airframe s basic aerodynamic characteristics. Comments on general airframe integrated scramjet propulsion system effects on vehicle aerodynamic performance, stability, and control are provided, followed by examples specific to the Hyper-X research vehicle. An overview is provided of the current activities associated with the development of the Hyper-X aerodynamic database, including wind tunnel test activities and parallel CFD analysis efforts. A brief summary of the Hyper-X aerodynamic characteristics is provided, including the direct and indirect effects of the airframe integrated scramjet propulsion system operation on the basic airframe stability and control characteristics.
Activity-Based Protein Profiling of Microbes
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sadler, Natalie C.; Wright, Aaron T.
Activity-Based Protein Profiling (ABPP) in conjunction with multimodal characterization techniques has yielded impactful findings in microbiology, particularly in pathogen, bioenergy, drug discovery, and environmental research. Using small molecule chemical probes that react irreversibly with specific proteins or protein families in complex systems has provided insights in enzyme functions in central metabolic pathways, drug-protein interactions, and regulatory protein redox, for systems ranging from photoautotrophic cyanobacteria to mycobacteria, and combining live cell or cell extract ABPP with proteomics, molecular biology, modeling, and other techniques has greatly expanded our understanding of these systems. New opportunities for application of ABPP to microbial systems include:more » enhancing protein annotation, characterizing protein activities in myriad environments, and reveal signal transduction and regulatory mechanisms in microbial systems.« less
GSFC Technology Development Center Report
NASA Technical Reports Server (NTRS)
Himwich, Ed; Gipson, John
2013-01-01
This report summarizes the activities of the GSFC Technology Development Center (TDC) for 2012 and forecasts planned activities for 2013. The GSFC TDC develops station software including the Field System (FS), scheduling software (SKED), hardware including tools for station timing and meteorology, scheduling algorithms, and operational procedures. It provides a pool of individuals to assist with station implementation, check-out, upgrades, and training.
NASA Hydrogen Research for Spaceport and Space Based Applications
NASA Technical Reports Server (NTRS)
Anderson, Tim
2005-01-01
Project management activities for this grant includes internal oversight, coordination and facilitation among research groups (internal to UF and external); system and/or trade studies to assist in evaluating and prioritizing new hydrogen production processes that may become available for potential research investigations; a technical and programmatic outreach activity; and formal reporting, including periodic technical reviews with the NASA team.
77 FR 19667 - Agency Information Collection Activities: Proposed Collection; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-02
... support research on health care and on systems for the delivery of such care, including activities with... Information Collection Activities: Proposed Collection; Comment Request AGENCY: Agency for Healthcare Research and Quality, HHS. ACTION: Notice. SUMMARY: This notice announces the intention of the Agency for...
The Older Woman: Increased Psychosocial Benefits from Physical Activity.
ERIC Educational Resources Information Center
Wakat, Diane; Odom, Sarah
1982-01-01
Older women who participate in physical activity programs find physical benefits in the improvement of cardiovascular and musculoskeletal systems. The psychosocial benefits which result from physical activity include an increase in self-esteem, increased social contacts, a counteraction to depression, and improved stress management. Suggestions…
30 CFR 250.802 - Design, installation, and operation of surface production-safety systems.
Code of Federal Regulations, 2010 CFR
2010-07-01
... properly or if any fluid flow is observed during the leakage test, the valve shall be repaired or replaced... maintenance of all fire- and gas-detection systems shall include the following: (i) Type, location, and number of detection sensors; (ii) Type and kind of alarms, including emergency equipment to be activated...
Coastal bathymetry data collected in 2011 from the Chandeleur Islands, Louisiana
DeWitt, Nancy T.; Pfeiffer, William R.; Bernier, Julie C.; Buster, Noreen A.; Miselis, Jennifer L.; Flocks, James G.; Reynolds, Billy J.; Wiese, Dana S.; Kelso, Kyle W.
2014-01-01
This report serves as an archive of processed interferometric swath and single-beam bathymetry data. Geographic Iinformation System data products include a 50-meter cell-size interpolated bathymetry grid surface, trackline maps, and point data files. Additional files include error analysis maps, Field Activity Collection System logs, and formal Federal Geographic Data Committee metadata.
Self-reported use of an implanted FES hand system by adolescents with tetraplegia.
Davis, S E; Mulcahey, M J; Smith, B T; Betz, R R
1998-07-01
The Freehand System, an eight-channel functional electrical stimulation (FES) system, was implanted in five adolescents with C-5 or C-6 tetraplegia to provide stimulated lateral pinch and palmar grasp. Following completion of inpatient training on how to use the Freehand System for predefined and self-selected activities of daily living (ADL), the adolescents were discharged to use their Freehand systems at home and school. A telephone survey was administered on a weekly basis to obtain information on the type of ADL performed with the Freehand System, reasons for not using the Freehand System, and perceived barriers and motivators to FES use. Twenty surveys were obtained on each adolescent, resulting in a total of 100 surveys. The most common type of activity performed with the Freehand System was self-care, which included tasks such as eating, grooming, and brushing teeth. The Freehand System was also used for productivity activities defined as writing, socialization, and manipulation of school and household objects. Motivators to Freehand System use included perceived need and importance to perform an ADL in an independent fashion, physical ease of using the Freehand System, and availability of social supports that facilitated Freehand System use. While there were several reported barriers to Freehand System use, incompatibility with multiple transfers to and from the wheelchair and lack of physical assistance during morning care to don the system were perceived as two of the more common reasons for nonuse.
Evaluation of mercury in the liquid waste processing facilities
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jain, Vijay; Shah, Hasmukh; Occhipinti, John E.
2015-08-13
This report provides a summary of Phase I activities conducted to support an Integrated Evaluation of Mercury in Liquid Waste System (LWS) Processing Facilities. Phase I activities included a review and assessment of the liquid waste inventory and chemical processing behavior of mercury using a system by system review methodology approach. Gaps in understanding mercury behavior as well as action items from the structured reviews are being tracked. 64% of the gaps and actions have been resolved.
1988-12-30
LIMITING ACTIVATED ZOLUTION OF HYPOCHLORITE), SADS (SURFACE ACTIVE DISPLACEMENT SYSTEMS ), SACRIFICIAL COAT!ý:GS, MICRO EMULSIONS , DS2, STB SLURRY...CURRENT SYSTEMS AND THOSE IN DEVELOPMENT WITH NOT MEET ALL DECONTAMINATION NEEDS. ITEMS TO BE FIELDED WILL INCLUDE: AN EMULSION BSED DECONTAMINATION...DECONTAMINATION SYSTEM FOR AIRCRAFT EXTERIORS; MICROEMULSIONS CONTAINING REACTIVE DECONTAMINANTS (FORMULATION, EFFICACY, AND 181 OPTIMIZATION); COOLING OF
NASA Technical Reports Server (NTRS)
Malin, Jane T.; Leifker, Daniel B.
1991-01-01
Current qualitative device and process models represent only the structure and behavior of physical systems. However, systems in the real world include goal-oriented activities that generally cannot be easily represented using current modeling techniques. An extension of a qualitative modeling system, known as functional modeling, which captures goal-oriented activities explicitly is proposed and how they may be used to support intelligent automation and fault management is shown.
[STS-31 Onboard 16mm Photography Quick Release]. [Onboard Activities
NASA Technical Reports Server (NTRS)
1990-01-01
This video features scenes shot by the crew of onboard activities including Hubble Space Telescope deploy, remote manipulator system (RMS) checkout, flight deck and middeck experiments, and Earth and payload bay views.
How-To-Do-It: Pig Foot Anatomy.
ERIC Educational Resources Information Center
Rowe, Paula M.
1988-01-01
Described is an activity used to introduce the anatomy of the skeletal and muscular systems. A teacher conducted, video enhanced demonstration and a student activity are discussed. Included is a sample student laboratory paper. (CW)
Desert Peak East Enhanced Geothermal Systems (EGS) Project
DOE Office of Scientific and Technical Information (OSTI.GOV)
Zemach, Ezra; Drakos, Peter; Spielman, Paul
2013-09-30
This manuscript is a draft to replaced with a final version at a later date TBD. A summary of activities pertaining to the Desert Peak EGS project including the planning and resulting stimulation activities.
Birthdays and the Binary System: A Magical Mixture.
ERIC Educational Resources Information Center
Karp, Karen S.; Ronau, Robert N.
1997-01-01
Presents an activity involving the use of students' birth dates. Activity includes a classic binary representation of numerical values. In the Green Machine, Sorting Cards, and Window Cards, students observe, describe, and analyze patterns. (PVD)
Chaigne, Benjamin; Chizzolini, Carlo; Perneger, Thomas; Trendelenburg, Marten; Huynh-Do, Uyen; Dayer, Eric; Stoll, Thomas; von Kempis, Johannes; Ribi, Camillo
2017-03-28
To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE). Cross-sectional study of patients included in the Swiss SLE Cohort Study between April 2007 and June 2014. HRQoL outcomes were based on the Medical Outcome Study Short Form 36 (SF-36). Disease activity was assessed by the SLE Disease Activity Index score with the Safety of Estrogens in SLE National Assessment modification (SELENA-SLEDAI) and by the physican's global assessment (PGA). Of the 252 patients included, 207 (82%) were women. Median [interquartile range (IQR)] age was 43 [32-57] years. SLE was active in 125 patients (49.6%). Median [IQR] mental component summary (MCS) in active vs inactive SLE was 40.0 [30.2-51.0] compared to 47.3 [39.2-52.8] (p < 0.01) and median [IQR] physical component summary (PCS) 43.7 [37.0-52.8] compared to 49.1 [38.4-55.6], respectively (p < 0.05). Increase in SELENA-SLEDAI or increase in PGA were negatively correlated with PCS and/or MCS. After adjusting for gender, age and disease duration, disease activity impacted on both PCS and MCS and all subscales except general health. Active lupus nephritis and musculoskeletal involvement were associated with physical limitations and emotional problems, increased bodily pain and poor social functioning. Low complement and/or presence of anti-dsDNA antibodies were associated with increased fatigue and reduced mental health. In patients with SLE, HRQoL is reduced in those with active disease. Impact of disease activity on HRQoL dimensions depends on SELENA-SLEDAI system components.
Medical Information Management System (MIMS): An automated hospital information system
NASA Technical Reports Server (NTRS)
Alterescu, S.; Simmons, P. B.; Schwartz, R. A.
1971-01-01
An automated hospital information system that handles all data related to patient-care activities is described. The description is designed to serve as a manual for potential users, nontechnical medical personnel who may use the system. Examples of the system's operation, commentary on the examples, and a complete listing of the system program are included.
Advanced EVA system design requirements study, executive summary
NASA Technical Reports Server (NTRS)
1986-01-01
Design requirements and criteria for the space station advanced Extravehicular Activity System (EVAS) including crew enclosures, portable life support systems, maneuvering propulsion systems, and related EVA support equipment were established. The EVA mission requirements, environments, and medical and physiological requirements, as well as operational, procedures and training issues were considered.
78 FR 25840 - Installed Systems and Equipment for Use by the Flightcrew
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-03
... certified aircraft (examples include updating avionics systems, engines, drag reduction, interior... aircraft systems, equipment, and the aircraft itself, so that they understand the situation better. Active...-1175; Amdt. No. 25-138] RIN 2120-AJ83 Installed Systems and Equipment for Use by the Flightcrew AGENCY...
Analyzing Automated Instructional Systems: Metaphors from Related Design Professions.
ERIC Educational Resources Information Center
Jonassen, David H.; Wilson, Brent G.
Noting that automation has had an impact on virtually every manufacturing and information operation in the world, including instructional design (ID), this paper suggests three basic metaphors for automating instructional design activities: (1) computer-aided design and manufacturing (CAD/CAM) systems; (2) expert system advisor systems; and (3)…
Granger, Catherine L; Denehy, Linda; Remedios, Louisa; Retica, Sarah; Phongpagdi, Pimsiri; Hart, Nicholas; Parry, Selina M
2016-12-01
Evidence-based clinical practice guidelines recommend physical activity for people with lung cancer, however evidence has not translated into clinical practice and the majority of patients do not meet recommended activity levels. To identify factors (barriers and enablers) that influence clinicians' translation of the physical activity guidelines into practice. Qualitative study involving 17 participants (three respiratory physicians, two thoracic surgeons, two oncologists, two nurses, and eight physical therapists) who were recruited using purposive sampling from five hospitals in Melbourne, Victoria, Australia. Nine semistructured interviews and a focus group were conducted, transcribed verbatim, and independently cross-checked by a second researcher. Thematic analysis was used to analyze data. Five consistent themes emerged: (1) the clinicians perception of patient-related physical and psychological influences (including symptoms and comorbidities) that impact on patient's ability to perform regular physical activity; (2) the influence of the patient's past physical activity behavior and their perceived relevance and knowledge about physical activity; (3) the clinicians own knowledge and beliefs about physical activity; (4) workplace culture supporting or hindering physical activity; and (5) environmental and structural influences in the healthcare system (included clinicians time, staffing, protocols and services). Clinicians described potential strategies, including: (1) the opportunity for nurse practitioners to act as champions of regular physical activity and triage referrals for physical activity services; (2) opportunistically using the time when patients are in hospital after surgery to discuss physical activity; and (3) for all members of the multidisciplinary team to provide consistent messages to patients about the importance of physical activity. Key barriers to implementation of the physical activity guidelines in lung cancer are diverse and include both clinician- and healthcare system-related factors. A combined approach to target a number of these factors should be used to inform research, improve clinical services, and develop policies aiming to increase physical activity and improve survivorship outcomes for patients with lung cancer.
Dynamically variable spot size laser system
NASA Technical Reports Server (NTRS)
Gradl, Paul R. (Inventor); Hurst, John F. (Inventor); Middleton, James R. (Inventor)
2012-01-01
A Dynamically Variable Spot Size (DVSS) laser system for bonding metal components includes an elongated housing containing a light entry aperture coupled to a laser beam transmission cable and a light exit aperture. A plurality of lenses contained within the housing focus a laser beam from the light entry aperture through the light exit aperture. The lenses may be dynamically adjusted to vary the spot size of the laser. A plurality of interoperable safety devices, including a manually depressible interlock switch, an internal proximity sensor, a remotely operated potentiometer, a remotely activated toggle and a power supply interlock, prevent activation of the laser and DVSS laser system if each safety device does not provide a closed circuit. The remotely operated potentiometer also provides continuous variability in laser energy output.
The Telecommunications and Data Acquisition Report
NASA Technical Reports Server (NTRS)
Yuen, Joseph H. (Editor)
1995-01-01
This quarterly publiction provides archival reports on developments in programs managed by JPL Telecommunications and Mission Operations Directorate (TMOD), which now includes the former communications and Data Acquisition (TDA) Office. In space communications, radio navigation, radio science, and ground-based radio and radar astronomy, it reports on activities of the Deep Space Network (DSN) in planning, supporting research and technology, implementation, and operations. Also included are standards activity at JPL for space data and information systems and reimbursable DSN work performed for other space agencies through NASA. The Orbital Debris Radar Program, funded by the Office of Space Systems Development, makes use of the planetary radar capability when the antennas are configured at science instruments making direct observations of planets, their satellites, and asteroids of our solar system.
Apparatus and method for gas turbine active combustion control system
NASA Technical Reports Server (NTRS)
Knobloch, Aaron (Inventor); Mancini, Alfred Albert (Inventor); Myers, William J. (Inventor); Fortin, Jeffrey B. (Inventor); Umeh, Chukwueloka (Inventor); Kammer, Leonardo C. (Inventor); Shah, Minesh (Inventor)
2011-01-01
An Active Combustion Control System and method provides for monitoring combustor pressure and modulating fuel to a gas turbine combustor to prevent combustion dynamics and/or flame extinguishments. The system includes an actuator, wherein the actuator periodically injects pulsed fuel into the combustor. The apparatus also includes a sensor connected to the combustion chamber down stream from an inlet, where the sensor generates a signal detecting the pressure oscillations in the combustor. The apparatus controls the actuator in response to the sensor. The apparatus prompts the actuator to periodically inject pulsed fuel into the combustor at a predetermined sympathetic frequency and magnitude, thereby controlling the amplitude of the pressure oscillations in the combustor by modulating the natural oscillations.
Looking at Earth from Space: Teacher's Guide with Activities for Earth and Space Science
NASA Technical Reports Server (NTRS)
Steele, Colleen (Editor); Steele, Colleen; Ryan, William F.
1995-01-01
The Maryland Pilot Earth Science and Technology Education Network (MAPS-NET) project was sponsored by the National Aeronautics and Space Administration (NASA) to enrich teacher preparation and classroom learning in the area of Earth system science. This publication includes a teacher's guide that replicates material taught during a graduate-level course of the project and activities developed by the teachers. The publication was developed to provide teachers with a comprehensive approach to using satellite imagery to enhance science education. The teacher's guide is divided into topical chapters and enables teachers to expand their knowledge of the atmosphere, common weather patterns, and remote sensing. Topics include: weather systems and satellite imagery including mid-latitude weather systems; wave motion and the general circulation; cyclonic disturbances and baroclinic instability; clouds; additional common weather patterns; satellite images and the internet; environmental satellites; orbits; and ground station set-up. Activities are listed by suggested grade level and include the following topics: using weather symbols; forecasting the weather; cloud families and identification; classification of cloud types through infrared Automatic Picture Transmission (APT) imagery; comparison of visible and infrared imagery; cold fronts; to ski or not to ski (imagery as a decision making tool), infrared and visible satellite images; thunderstorms; looping satellite images; hurricanes; intertropical convergence zone; and using weather satellite images to enhance a study of the Chesapeake Bay. A list of resources is also included.
Kanner, J; Harel, S
1987-01-01
Desferrioxamine (DFO) involvement in several peroxidative systems was studied. These systems included: a) membranal lipid peroxidation initiated by H2O2-activated metmyoglobin (or methemoglobin); b) phenol-red oxidation by activated metmyoglobin or horseradish peroxidase (HRP): c) beta-carotene-linoleate couple oxidation stimulated by lipoxygenase or hemin. Desferrioxamine was found to inhibit all these systems but not ferrioxamine (FO). Phenol-red oxidation by H2O2-horseradish peroxidase was inhibited competitively with DFO. Kinetic studies using the spectra changes in the Soret region of metmyoglobin suggest a mechanism by which H2O2 reacts with the iron-heme to form an intermediate of oxy-ferryl myoglobin that subsequently reacts with DFO to return the activated compound to the resting state. These activities of DFO resemble the reaction of other electron donors.
Calculating a checksum with inactive networking components in a computing system
Aho, Michael E; Chen, Dong; Eisley, Noel A; Gooding, Thomas M; Heidelberger, Philip; Tauferner, Andrew T
2014-12-16
Calculating a checksum utilizing inactive networking components in a computing system, including: identifying, by a checksum distribution manager, an inactive networking component, wherein the inactive networking component includes a checksum calculation engine for computing a checksum; sending, to the inactive networking component by the checksum distribution manager, metadata describing a block of data to be transmitted by an active networking component; calculating, by the inactive networking component, a checksum for the block of data; transmitting, to the checksum distribution manager from the inactive networking component, the checksum for the block of data; and sending, by the active networking component, a data communications message that includes the block of data and the checksum for the block of data.
Calculating a checksum with inactive networking components in a computing system
Aho, Michael E; Chen, Dong; Eisley, Noel A; Gooding, Thomas M; Heidelberger, Philip; Tauferner, Andrew T
2015-01-27
Calculating a checksum utilizing inactive networking components in a computing system, including: identifying, by a checksum distribution manager, an inactive networking component, wherein the inactive networking component includes a checksum calculation engine for computing a checksum; sending, to the inactive networking component by the checksum distribution manager, metadata describing a block of data to be transmitted by an active networking component; calculating, by the inactive networking component, a checksum for the block of data; transmitting, to the checksum distribution manager from the inactive networking component, the checksum for the block of data; and sending, by the active networking component, a data communications message that includes the block of data and the checksum for the block of data.
Installation of Existing Lift Systems for the Handicapped on Light Rail Vehicles
DOT National Transportation Integrated Search
1985-05-01
This report documents the results of a three-phase program to install an existing transit bus wheelchair lift system on a Boeing Light Rail Vehicle (LRV). Program activities included a review of lift requirements, evaluation of existing lift systems,...
10 CFR 70.72 - Facility changes and change process.
Code of Federal Regulations, 2010 CFR
2010-01-01
... management system to evaluate, implement, and track each change to the site, structures, processes, systems, equipment, components, computer programs, and activities of personnel. This system must be documented in... licensed material; (3) Modifications to existing operating procedures including any necessary training or...
10 CFR 70.72 - Facility changes and change process.
Code of Federal Regulations, 2011 CFR
2011-01-01
... management system to evaluate, implement, and track each change to the site, structures, processes, systems, equipment, components, computer programs, and activities of personnel. This system must be documented in... licensed material; (3) Modifications to existing operating procedures including any necessary training or...
10 CFR 70.72 - Facility changes and change process.
Code of Federal Regulations, 2012 CFR
2012-01-01
... management system to evaluate, implement, and track each change to the site, structures, processes, systems, equipment, components, computer programs, and activities of personnel. This system must be documented in... licensed material; (3) Modifications to existing operating procedures including any necessary training or...
10 CFR 70.72 - Facility changes and change process.
Code of Federal Regulations, 2014 CFR
2014-01-01
... management system to evaluate, implement, and track each change to the site, structures, processes, systems, equipment, components, computer programs, and activities of personnel. This system must be documented in... licensed material; (3) Modifications to existing operating procedures including any necessary training or...
10 CFR 70.72 - Facility changes and change process.
Code of Federal Regulations, 2013 CFR
2013-01-01
... management system to evaluate, implement, and track each change to the site, structures, processes, systems, equipment, components, computer programs, and activities of personnel. This system must be documented in... licensed material; (3) Modifications to existing operating procedures including any necessary training or...
Space station WP-04 power system. Volume 1: Executive summary
NASA Technical Reports Server (NTRS)
Hallinan, G. J.
1987-01-01
Major study activities and results of the phase B study contract for the preliminary design of the space station Electrical Power System (EPS) are summarized. The areas addressed include the general system design, man-tended option, automation and robotics, evolutionary growth, software development environment, advanced development, customer accommodations, operations planning, product assurance, and design and development phase planning. The EPS consists of a combination photovoltaic and solar dynamic power generation subsystem and a power management and distribution (PMAD) subsystem. System trade studies and costing activities are also summarized.
Inertial navigation sensor integrated obstacle detection system
NASA Technical Reports Server (NTRS)
Bhanu, Bir (Inventor); Roberts, Barry A. (Inventor)
1992-01-01
A system that incorporates inertial sensor information into optical flow computations to detect obstacles and to provide alternative navigational paths free from obstacles. The system is a maximally passive obstacle detection system that makes selective use of an active sensor. The active detection typically utilizes a laser. Passive sensor suite includes binocular stereo, motion stereo and variable fields-of-view. Optical flow computations involve extraction, derotation and matching of interest points from sequential frames of imagery, for range interpolation of the sensed scene, which in turn provides obstacle information for purposes of safe navigation.
Multi-carrier mobile TDMA system with active array antenna
NASA Technical Reports Server (NTRS)
Suzuki, Ryutaro; Matsumoto, Yasushi; Hamamoto, Naokazu
1990-01-01
A multi-carrier time division multiple access (TDMA) is proposed for the future mobile satellite communications systems that include a multi-satellite system. This TDMA system employs the active array antenna in which the digital beam forming technique is adopted to control the antenna beam direction. The antenna beam forming is carried out at the base band frequency by using the digital signal processing technique. The time division duplex technique is applied for the TDM/TDMA burst format, in order not to overlap transmit and receive timing.
Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin
2014-07-02
Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital.
Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin
2014-01-01
Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital. PMID:24991942
Reflexive aerostructures: increased vehicle survivability
NASA Astrophysics Data System (ADS)
Margraf, Thomas W.; Hemmelgarn, Christopher D.; Barnell, Thomas J.; Franklin, Mark A.
2007-04-01
Aerospace systems stand to benefit significantly from the advancement of reflexive aerostructure technologies for increased vehicle survivability. Cornerstone Research Group Inc. (CRG) is developing lightweight, healable composite systems for use as primary load-bearing aircraft components. The reflexive system is comprised of piezoelectric structural health monitoring systems, localized thermal activation systems, and lightweight, healable composite structures. The reflexive system is designed to mimic the involuntary human response to damage. Upon impact, the structural health monitoring system will identify the location and magnitude of the damage, sending a signal to a discrete thermal activation control system to resistively heat the shape memory polymer (SMP) matrix composite above activation temperature, resulting in localized shape recovery and healing of the damaged areas. CRG has demonstrated SMP composites that can recover 90 percent of flexural yield stress and modulus after postfailure healing. During the development, CRG has overcome issues of discrete activation, structural health monitoring integration, and healable resin systems. This paper will address the challenges associated with development of a reflexive aerostructure, including integration of structural health monitoring, discrete healing, and healable shape memory resin systems.
Aeronautics and space report of the president, 1974 activities
NASA Technical Reports Server (NTRS)
1975-01-01
The U.S. Government activities for 1974 in aeronautics and space are presented. Significant contributions toward the fulfillment of the nation's goals in space and aeronautics are covered, including application of space systems and technology to beneficial uses on earth, exploration of space and increase of scientific knowledge, development of improved space systems and technology, international cooperation, and advancement of civil and military aeronautics. Also in 1974, space activities in the private sector expanded to provide additional services to the public. The accomplishments are summarized.
Install active/passive neutron examination and assay (APNEA)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1996-04-01
This document describes activities pertinent to the installation of the prototype Active/Passive Neutron Examination and Assay (APNEA) system built in Area 336 into its specially designed trailer. It also documents the basic theory of operation, design and protective features, basic personnel training, and the proposed characterization site location at Lockheed Martin Specialty Components, Inc., (Specialty Components) with the estimated 10 mrem/year boundary. Additionally, the document includes the Preventive Change Analysis (PCA) form, and a checklist of items for verification prior to unrestricted system use.
Developing a Promotional Campaign for a Statewide Continuing Education System.
ERIC Educational Resources Information Center
Munger, Paul; And Others
1981-01-01
Describes activities developed in promoting a statewide continuing education system. They included television and radio advertisements, a user's manual, and a logo. Program evaluation and implementation are also discussed. (CT)
Integrated active sensor system for real time vibration monitoring.
Liang, Qijie; Yan, Xiaoqin; Liao, Xinqin; Cao, Shiyao; Lu, Shengnan; Zheng, Xin; Zhang, Yue
2015-11-05
We report a self-powered, lightweight and cost-effective active sensor system for vibration monitoring with multiplexed operation based on contact electrification between sensor and detected objects. The as-fabricated sensor matrix is capable of monitoring and mapping the vibration state of large amounts of units. The monitoring contents include: on-off state, vibration frequency and vibration amplitude of each unit. The active sensor system delivers a detection range of 0-60 Hz, high accuracy (relative error below 0.42%), long-term stability (10000 cycles). On the time dimension, the sensor can provide the vibration process memory by recording the outputs of the sensor system in an extend period of time. Besides, the developed sensor system can realize detection under contact mode and non-contact mode. Its high performance is not sensitive to the shape or the conductivity of the detected object. With these features, the active sensor system has great potential in automatic control, remote operation, surveillance and security systems.
Integrated active sensor system for real time vibration monitoring
Liang, Qijie; Yan, Xiaoqin; Liao, Xinqin; Cao, Shiyao; Lu, Shengnan; Zheng, Xin; Zhang, Yue
2015-01-01
We report a self-powered, lightweight and cost-effective active sensor system for vibration monitoring with multiplexed operation based on contact electrification between sensor and detected objects. The as-fabricated sensor matrix is capable of monitoring and mapping the vibration state of large amounts of units. The monitoring contents include: on-off state, vibration frequency and vibration amplitude of each unit. The active sensor system delivers a detection range of 0–60 Hz, high accuracy (relative error below 0.42%), long-term stability (10000 cycles). On the time dimension, the sensor can provide the vibration process memory by recording the outputs of the sensor system in an extend period of time. Besides, the developed sensor system can realize detection under contact mode and non-contact mode. Its high performance is not sensitive to the shape or the conductivity of the detected object. With these features, the active sensor system has great potential in automatic control, remote operation, surveillance and security systems. PMID:26538293
Automated Rocket Propulsion Test Management
NASA Technical Reports Server (NTRS)
Walters, Ian; Nelson, Cheryl; Jones, Helene
2007-01-01
The Rocket Propulsion Test-Automated Management System provides a central location for managing activities associated with Rocket Propulsion Test Management Board, National Rocket Propulsion Test Alliance, and the Senior Steering Group business management activities. A set of authorized users, both on-site and off-site with regard to Stennis Space Center (SSC), can access the system through a Web interface. Web-based forms are used for user input with generation and electronic distribution of reports easily accessible. Major functions managed by this software include meeting agenda management, meeting minutes, action requests, action items, directives, and recommendations. Additional functions include electronic review, approval, and signatures. A repository/library of documents is available for users, and all items are tracked in the system by unique identification numbers and status (open, closed, percent complete, etc.). The system also provides queries and version control for input of all items.
Brien, Susan; Gheihman, Galina; Tse, Yi Ki Yvonne; Byrnes, Mary; Harrison, Sophia; Dobrow, Mark J
2014-05-01
Jurisdictions are increasingly focusing on appropriate use of healthcare services and interventions as a means to improve health system performance. Our objectives were to conduct a scoping review to (a) map Canadian research and related activity on system-level appropriateness of care and (b) create a resource database that could be used to inform evidence-based decision-making and future research priorities in this area. We searched Medline, EMBASE and CINAHL databases between 2003-2013 using terms including "appropriate," "inappropriate," "health technology assessment" and "cost-effectiveness." Articles were included if they were Canadian-based and relevant to our definition. The database search was complemented by a website search of relevant Canadian organizations. 4,979 articles were identified through the literature search, and 103 articles relevant to system-level appropriateness of care across Canada were charted. Of these, 64 contained an evaluation of appropriateness, 30 used a method of cost-effectiveness or total cost impact analysis and 9 involved another methodology. The most common health service categories included drug therapy (n=40) and health service utilization (n=33). Fifty-eight websites were summarized containing material relevant to system-level appropriateness of care. Our review identifies Canadian research and related activity pertaining to appropriateness of healthcare from a system-level perspective and provides a useful resource both to support evidence-based decision-making and to guide future appropriateness research. Copyright © 2014 Longwoods Publishing.
An integrated decision support system for TRAC: A proposal
NASA Technical Reports Server (NTRS)
Mukkamala, Ravi
1991-01-01
Optimal allocation and usage of resources is a key to effective management. Resources of concern to TRAC are: Manpower (PSY), Money (Travel, contracts), Computing, Data, Models, etc. Management activities of TRAC include: Planning, Programming, Tasking, Monitoring, Updating, and Coordinating. Existing systems are insufficient, not completely automated, manpower intensive, and has the potential for data inconsistency exists. A system is proposed which suggests a means to integrate all project management activities of TRAC through the development of a sophisticated software and by utilizing the existing computing systems and network resources. The systems integration proposal is examined in detail.
Prebiotics as immunostimulants in aquaculture: a review.
Song, Seong Kyu; Beck, Bo Ram; Kim, Daniel; Park, John; Kim, Jungjoon; Kim, Hyun Duk; Ringø, Einar
2014-09-01
Prebiotics are indigestible fibers that increase beneficial gut commensal bacteria resulting in improvements of the host's health. The beneficial effects of prebiotics are due to the byproducts generated from their fermentation by gut commensal bacteria. In this review, the direct effects of prebiotics on the innate immune system of fish are discussed. Prebiotics, such as fructooligosaccharide, mannanoligosaccharide, inulin, or β-glucan, are called immunosaccharides. They directly enhance innate immune responses including: phagocytic activation, neutrophil activation, activation of the alternative complement system, increased lysozyme activity, and more. Immunosaccharides directly activate the innate immune system by interacting with pattern recognition receptors (PRR) expressed on innate immune cells. They can also associate with microbe associated molecular patterns (MAMPs) to activate innate immune cells. However, the underlying mechanisms involved in innate immune cell activation need to be further explored. Many studies have indicated that immunosaccharides are beneficial to both finfish and shellfish. Copyright © 2014 Elsevier Ltd. All rights reserved.
DOE Office of Scientific and Technical Information (OSTI.GOV)
NONE
This report summarizes geothermal technical assistance, R&D, and technology transfer activities of the Geo-Heat Center. It describes 95 contacts with parties during this period related to technical assistance with goethermal direct heat projects. Areas dealt with include geothermal heat pumps, space heating, greenhouses, aquaculture, equipment, economics, and resources. Research activities are summarized on geothermal district heating system cost evaluation and silica waste utilization project. Outreach activities include publication of a geothermal direct use Bulletin, dissemination of information, goethermal library, technical papers and seminars, and progress monitor reports on geothermal resources and utilization.
Advanced Active-Magnetic-Bearing Thrust-Measurement System
NASA Technical Reports Server (NTRS)
Imlach, Joseph; Kasarda, Mary; Blumber, Eric
2008-01-01
An advanced thrust-measurement system utilizes active magnetic bearings to both (1) levitate a floating frame in all six degrees of freedom and (2) measure the levitation forces between the floating frame and a grounded frame. This system was developed for original use in measuring the thrust exerted by a rocket engine mounted on the floating frame, but can just as well be used in other force-measurement applications. This system offers several advantages over prior thrust-measurement systems based on mechanical support by flexures and/or load cells: The system includes multiple active magnetic bearings for each degree of freedom, so that by selective use of one, some, or all of these bearings, it is possible to test a given article over a wide force range in the same fixture, eliminating the need to transfer the article to different test fixtures to obtain the benefit of full-scale accuracy of different force-measurement devices for different force ranges. Like other active magnetic bearings, the active magnetic bearings of this system include closed-loop control subsystems, through which the stiffness and damping characteristics of the magnetic bearings can be modified electronically. The design of the system minimizes or eliminates cross-axis force-measurement errors. The active magnetic bearings are configured to provide support against movement along all three orthogonal Cartesian axes, and such that the support along a given axis does not produce force along any other axis. Moreover, by eliminating the need for such mechanical connections as flexures used in prior thrust-measurement systems, magnetic levitation of the floating frame eliminates what would otherwise be major sources of cross-axis forces and the associated measurement errors. Overall, relative to prior mechanical-support thrust-measurement systems, this system offers greater versatility for adaptation to a variety of test conditions and requirements. The basic idea of most prior active-magnetic-bearing force-measurement systems is to calculate levitation forces on the basis of simple proportionalities between changes in those forces and changes in feedback-controlled currents applied to levitating electromagnetic coils. In the prior systems, the effects of gap lengths on fringing magnetic fields and the concomitant effects on magnetic forces were neglected. In the present system, the control subsystems of the active magnetic bearings are coupled with a computer-based automatic calibration system running special-purpose software wherein gap-length-dependent fringing factors are applied to current and magnetic-flux-based force equations and combined with a multipoint calibration method to obtain greater accuracy.
Student Organizations--FBLA Projects and Activities Relating to Free Enterprise.
ERIC Educational Resources Information Center
Western Kentucky Univ., Bowling Green.
This guide for Future Business Leaders of America and Phi Beta Lambda chapters describes 25 economic awareness projects/activities to create awareness of the free enterprise economic system. Introductory materials include suggestions for project planning and management and a worksheet for planning activities and projects. The projects/activities…
Tractor Mechanics: Learning Activity Packages 1-19.
ERIC Educational Resources Information Center
Clemson Univ., SC. Vocational Education Media Center.
Learning activity packages are presented for teaching tractor mechanics. The first of two sections deals with miscellaneous tasks and contains learning activity packages on cleaning the tractor and receiving new tractor parts. Section 2 is concerned with maintaining and servicing the electrical system, and it includes the following learning…
Potential of preemptive DIRCM systems
NASA Astrophysics Data System (ADS)
Steinvall, Ove
2015-10-01
Manpads offer a severe threat to both civilian and military airborne platforms. The present countermeasure systems include platform maneuver, flares and DIRCM systems. Recently an increasing interest is aimed at preemptive measures e.g. to detect, identify and counter the threat before any missile has been launched. This will emphasize the importance of detecting and analyzing other signatures than those treated in conventional DIRCM systems. These may include laser emission from the target, detection of retro-reflections from optical sights and seekers as well as the optical signatures of the weapon and operator including the aiming and tracking activity. We will exemplify some of the concepts by experimental results and discuss some of the system and technology challenges.
Status of E-ELT M5 scale-one demonstrator
NASA Astrophysics Data System (ADS)
Barriga, Pablo; Sedghi, Babak; Dimmler, Martin; Kornweibel, Nick
2014-07-01
The fifth mirror of the European Extremely Large Telescope optical train is a field stabilization tip/tilt unit responsible for correcting the dynamical tip and tilt caused mainly by wind load on the telescope. A scale-one prototype including the inclined support, the fixed frame and a basic control system was designed and manufactured by NTE-SENER (Spain) and CSEM (Switzerland) as part of the prototyping and design activities. All interfaces to the mirror have been reproduced on a dummy structure reproducing the inertial characteristics of the optical element. The M5 unit is required to have sufficient bandwidth for tip/tilt reference commands coming from the wavefront control system. Such a bandwidth can be achieved using local active damping loop to damp the low frequency mechanical modes before closing a position loop. Prototyping on the M5 unit has been undertaken in order to demonstrate the E-ELT control system architecture, concepts and development standards and to further study active damping strategies. The control system consists of two nested loops: a local damping loop and a position loop. The development of this control system was undertaken following the E-ELT control system development standards in order to determine their applicability and performance and includes hardware selection, communication, synchronization, configuration, and data logging. In this paper we present the current status of the prototype M5 control system and the latest results on the active damping control strategy, in particular the promising results obtained with the method of positive position feedback.
Performance analysis of the ascent propulsion system of the Apollo spacecraft
NASA Technical Reports Server (NTRS)
Hooper, J. C., III
1973-01-01
Activities involved in the performance analysis of the Apollo lunar module ascent propulsion system are discussed. A description of the ascent propulsion system, including hardware, instrumentation, and system characteristics, is included. The methods used to predict the inflight performance and to establish performance uncertainties of the ascent propulsion system are discussed. The techniques of processing the telemetered flight data and performing postflight performance reconstruction to determine actual inflight performance are discussed. Problems that have been encountered and results from the analysis of the ascent propulsion system performance during the Apollo 9, 10, and 11 missions are presented.
[Serotoninergic system morphofunctional aspects in control of postural and locomotion function].
Gerasimenko, Iu P; Moshonkina, T R; Pavlova, N V; Tomilovskaia, E S; Kozlovskaia, I B
2012-12-01
Different mediator systems including serotoninergic one can influence animal's locomotor behavior. It has been shown that the spinal cord in the absence of supraspinal control is able to induce the locomotor activity in hindlimbs and afferent system can activate this mechanism. In behavioral studies on the rats with complete transection of the spinal cord it has been demonstrated that the pharmacological blocking of serotoninergic system results in depression of motor activity mediated by activation of support reactions. Histological studies did not reveal any effects of activation of support reactions on the safety of neurons as well as on the distribution of synaptic contacts within L2-L4 spinal segments. At the same time it has been shown that blockade of the serotoninergic system results in alterations of cells located in 1-3 laminae of dorsal horns, and in 7 Rexed's lamina as well as in redistribution of synaptic contacts in 1-4 Rexed laminae of the spinal cord dorsal horns.
Soft active matter: a contemporary example of Edwardsian statistical mechanics
NASA Astrophysics Data System (ADS)
Liverpool, Tanniemola
Colonies of swimming bacteria, algae or spermatozoa are examples of active systems composed of interacting units that consume energy and collectively generate motion and mechanical stresses. Due to the anisotropy of their interactions, these active particles can exhibit orientational order at high concentrations and have been called ``living liquid crystals''. Biology at the cellular and multicellular scale provides numerous examples of these active systems. They provide a novel class of experimentally accessible system far from equilibrium. Their rich collective behaviour includes non-equilibrium phase transitions and pattern formation on mesoscopic scales. Interestingly however, some of the theoretical insights gained from field theories applied to equilibrium soft matter systems can be used to explain aspects of their behaviour, but with a number of surprising new twists. I will describe and summarise recent theoretical results characterising the behaviour of such soft active systems highlighting in particular the effects of their internal dynamics on their macroscopic behaviour. With support of the EPSRC Grant No. EP/G026440/1.
Amparyup, Piti; Sutthangkul, Jantiwan; Charoensapsri, Walaiporn; Tassanakajon, Anchalee
2012-01-01
The prophenoloxidase (proPO) system is activated upon recognition of pathogens by pattern recognition proteins (PRPs), including a lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP). However, shrimp LGBPs that are involved in the proPO system have yet to be clarified. Here, we focus on characterizing the role of a Penaeus monodon LGBP (PmLGBP) in the proPO system. We found that PmLGBP transcripts are expressed primarily in the hemocytes and are increased at 24 h after pathogenic bacterium Vibrio harveyi challenge. The binding studies carried out using ELISA indicated that recombinant (r)PmLGBP binds to β-1,3-glucan and LPS with a dissociation constant of 6.86 × 10−7 m and 3.55 × 10−7 m, respectively. Furthermore, we found that rPmLGBP could enhance the phenoloxidase (PO) activity of hemocyte suspensions in the presence of LPS or β-1,3-glucan. Using dsRNA interference-mediated gene silencing assay, we further demonstrated that knockdown of PmLGBP in shrimp in vivo significantly decreased the PmLGBP transcript level but had no effect on the expression of the other immune genes tested, including shrimp antimicrobial peptides (AMPs). However, suppression of proPO expression down-regulated PmLGBP, proPO-activating enzyme (PmPPAE2), and AMPs (penaeidin and crustin). Such PmLGBP down-regulated shrimp showed significantly decreased total PO activity. We conclude that PmLGBP functions as a pattern recognition protein for LPS and β-1,3-glucan in the shrimp proPO activating system. PMID:22235126
Performance and economics of residential solar space heating
NASA Astrophysics Data System (ADS)
Zehr, F. J.; Vineyard, T. A.; Barnes, R. W.; Oneal, D. L.
1982-11-01
The performance and economics of residential solar space heating were studied for various locations in the contiguous United States. Common types of active and passive solar heating systems were analyzed with respect to an average-size, single-family house designed to meet or exceed the thermal requirements of the Department of Housing and Urban Development Minimum Property Standards (HUD-MPS). The solar systems were evaluated in seventeen cities to provide a broad range of climatic conditions. Active systems evaluated consist of air and liquid flat plate collectors with single- and double-glazing: passive systems include Trombe wall, water wall, direct gain, and sunspace systems. The active system solar heating performance was computed using the University of Wisconsin's F-CHART computer program. The Los Alamos Scientific Laboratory's Solar Load Ratio (SLR) method was employed to compute solar heating performance for the passive systems. Heating costs were computed with gas, oil, and electricity as backups and as conventional heating system fuels.
Alkaline and non-aqueous proton-conducting pouch-cell batteries
Young, Kwo-hsiung; Nei, Jean; Meng, Tiejun
2018-01-02
Provided are sealed pouch-cell batteries that are alkaline batteries or non-aqueous proton-conducing batteries. A pouch cell includes a flexible housing such as is used for pouch cell construction where the housing is in the form of a pouch, a cathode comprising a cathode active material suitable for use in an alkaline battery, an anode comprising an anode active material suitable for use in an alkaline battery, an electrolyte that is optionally an alkaline or proton-conducting electrolyte, and wherein the pouch does not include or require a safety vent or other gas absorbing or releasing system as the anode active material and the cathode active material do not increase the internal atmospheric pressure any more than 2 psig during cycling. The batteries provided function contrary to the art recognized belief that such battery systems were impossible due to unacceptable gas production during cycling.
Emergence of Chiral Phases in Active Torque Dipole Systems
NASA Astrophysics Data System (ADS)
Fialho, Ana; Tjhung, Elsen; Cates, Michael; Marenduzzo, Davide
The common description of active particles as active force dipoles fails to take into account that active processes in biological systems often exhibit chiral asymmetries, generating active chiral processes and torque dipoles. Examples of such systems include cytoskeleton filaments which interact with motor proteins and beating cilia and flagella. In particular, the generation of active torques by the actomyosin cytoskeleton has been linked to the break of chiral symmetry at a cellular level. This phenomenon could constitute the primary determinant for the break of left-right symmetry in many living organisms, e.g. the position of the human heart within the human body. In order to account for the effects of chirality, we consider active torque dipoles which generate a chiral active stress. We characterize quasi-1D and 2D systems of torque dipoles, using a combination of linear stability analysis and numerical simulations (Lattice Boltzmann). Our results show that activity drives a spontaneous breaking of chiral symmetry, leading to the self-assembly of a chiral phase, in the absence of any thermodynamic interactions favoring cholesteric ordering. At high values of activity, we also observe labyrinthine patterns where the activity-induced chiral ordering is highly frustrated.
Using SysML for verification and validation planning on the Large Synoptic Survey Telescope (LSST)
NASA Astrophysics Data System (ADS)
Selvy, Brian M.; Claver, Charles; Angeli, George
2014-08-01
This paper provides an overview of the tool, language, and methodology used for Verification and Validation Planning on the Large Synoptic Survey Telescope (LSST) Project. LSST has implemented a Model Based Systems Engineering (MBSE) approach as a means of defining all systems engineering planning and definition activities that have historically been captured in paper documents. Specifically, LSST has adopted the Systems Modeling Language (SysML) standard and is utilizing a software tool called Enterprise Architect, developed by Sparx Systems. Much of the historical use of SysML has focused on the early phases of the project life cycle. Our approach is to extend the advantages of MBSE into later stages of the construction project. This paper details the methodology employed to use the tool to document the verification planning phases, including the extension of the language to accommodate the project's needs. The process includes defining the Verification Plan for each requirement, which in turn consists of a Verification Requirement, Success Criteria, Verification Method(s), Verification Level, and Verification Owner. Each Verification Method for each Requirement is defined as a Verification Activity and mapped into Verification Events, which are collections of activities that can be executed concurrently in an efficient and complementary way. Verification Event dependency and sequences are modeled using Activity Diagrams. The methodology employed also ties in to the Project Management Control System (PMCS), which utilizes Primavera P6 software, mapping each Verification Activity as a step in a planned activity. This approach leads to full traceability from initial Requirement to scheduled, costed, and resource loaded PMCS task-based activities, ensuring all requirements will be verified.
Trends in Planetary Data Analysis. Executive summary of the Planetary Data Workshop
NASA Technical Reports Server (NTRS)
Evans, N.
1984-01-01
Planetary data include non-imaging remote sensing data, which includes spectrometric, radiometric, and polarimetric remote sensing observations. Also included are in-situ, radio/radar data, and Earth based observation. Also discussed is development of a planetary data system. A catalog to identify observations will be the initial entry point for all levels of users into the data system. There are seven distinct data support services: encyclopedia, data index, data inventory, browse, search, sample, and acquire. Data systems for planetary science users must provide access to data, process, store, and display data. Two standards will be incorporated into the planetary data system: Standard communications protocol and Standard format data unit. The data system configuration must combine a distributed system with those of a centralized system. Fiscal constraints have made prioritization important. Activities include saving previous mission data, planning/cost analysis, and publishing of proceedings.
The nocturnal bottleneck and the evolution of activity patterns in mammals.
Gerkema, Menno P; Davies, Wayne I L; Foster, Russell G; Menaker, Michael; Hut, Roelof A
2013-08-22
In 1942, Walls described the concept of a 'nocturnal bottleneck' in placental mammals, where these species could survive only by avoiding daytime activity during times in which dinosaurs were the dominant taxon. Walls based this concept of a longer episode of nocturnality in early eutherian mammals by comparing the visual systems of reptiles, birds and all three extant taxa of the mammalian lineage, namely the monotremes, marsupials (now included in the metatherians) and placentals (included in the eutherians). This review describes the status of what has become known as the nocturnal bottleneck hypothesis, giving an overview of the chronobiological patterns of activity. We review the ecological plausibility that the activity patterns of (early) eutherian mammals were restricted to the night, based on arguments relating to endothermia, energy balance, foraging and predation, taking into account recent palaeontological information. We also assess genes, relating to light detection (visual and non-visual systems) and the photolyase DNA protection system that were lost in the eutherian mammalian lineage. Our conclusion presently is that arguments in favour of the nocturnal bottleneck hypothesis in eutherians prevail.
The nocturnal bottleneck and the evolution of activity patterns in mammals
Gerkema, Menno P.; Davies, Wayne I. L.; Foster, Russell G.; Menaker, Michael; Hut, Roelof A.
2013-01-01
In 1942, Walls described the concept of a ‘nocturnal bottleneck’ in placental mammals, where these species could survive only by avoiding daytime activity during times in which dinosaurs were the dominant taxon. Walls based this concept of a longer episode of nocturnality in early eutherian mammals by comparing the visual systems of reptiles, birds and all three extant taxa of the mammalian lineage, namely the monotremes, marsupials (now included in the metatherians) and placentals (included in the eutherians). This review describes the status of what has become known as the nocturnal bottleneck hypothesis, giving an overview of the chronobiological patterns of activity. We review the ecological plausibility that the activity patterns of (early) eutherian mammals were restricted to the night, based on arguments relating to endothermia, energy balance, foraging and predation, taking into account recent palaeontological information. We also assess genes, relating to light detection (visual and non-visual systems) and the photolyase DNA protection system that were lost in the eutherian mammalian lineage. Our conclusion presently is that arguments in favour of the nocturnal bottleneck hypothesis in eutherians prevail. PMID:23825205
Assessment of anti-oxidant activity of plant extracts using microbial test systems.
Oktyabrsky, O; Vysochina, G; Muzyka, N; Samoilova, Z; Kukushkina, T; Smirnova, G
2009-04-01
To evaluate the anti-oxidant properties of extracts from 20 medicinal herbs growing in western Siberia using microbial test systems and different in vitro methods. In vivo anti-oxidant activity of extracts was evaluated for their capacity to protect bacteria, Escherichia coli, against bacteriostatic and bactericidal effects of H(2)O(2) and menadione, and action on anti-oxidant gene expression. In vitro anti-oxidant activity has been examined by a number of methods including: the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH(*))-scavenging assay, chelating activity and capacity to protect plasmid DNA against oxidative damage. In addition, total polyphenol content was determined. The extracts of Fragaria vesca, Rosa majalis, Pentaphylloides fruticosa, Alchemilla vulgaris and Pulmonaria mollis possessed the highest levels of anti-oxidant activity in vivo and in vitro. The protective properties were more closely related to the DPPH(*) radical-scavenging activity, tannin content and action on anti-oxidant gene expression than to other parameters. The extracts of medicinal plants may have anti-oxidant effects on bacteria simultaneously through several different pathways, including direct inhibition of reactive oxygen species, iron chelation and anti-oxidant genes induction. Using microbial test systems, we revealed herbs that may be used as potential sources of natural anti-oxidants.
Integrated control system for electron beam processes
NASA Astrophysics Data System (ADS)
Koleva, L.; Koleva, E.; Batchkova, I.; Mladenov, G.
2018-03-01
The ISO/IEC 62264 standard is widely used for integration of the business systems of a manufacturer with the corresponding manufacturing control systems based on hierarchical equipment models, functional data and manufacturing operations activity models. In order to achieve the integration of control systems, formal object communication models must be developed, together with manufacturing operations activity models, which coordinate the integration between different levels of control. In this article, the development of integrated control system for electron beam welding process is presented as part of a fully integrated control system of an electron beam plant, including also other additional processes: surface modification, electron beam evaporation, selective melting and electron beam diagnostics.
Juzyszyn, Z; Czerny, B; Myśliwiec, Z; Pawlik, A; Droździk, M
2010-06-01
The effect of artichoke extract on mitochondrial respiratory chain (MRC) activity in isolated rat liver mitochondria (including reaction kinetics) was studied. The effect of the extract on the activity of isolated cytochrome oxidase was also studied. Extract in the range of 0.68-2.72 microg/ml demonstrated potent and concentration-dependent inhibitory activity. Concentrations > or =5.4 microg/ml entirely inhibited MRC activity. The succinate oxidase system (MRC complexes II-IV) was the most potently inhibited, its activity at an extract concentration of 1.36 microg/ml being reduced by 63.3% compared with the control (p < 0.05). The results suggest a complex inhibitory mechanism of the extract. Inhibition of the succinate oxidase system was competitive (K(i) = 0.23 microg/ml), whereas isolated cytochrome oxidase was inhibited noncompetitively (K(i) = 126 microg/ml). The results of this study suggest that the salubrious effects of artichoke extracts may rely in part on the effects of their active compounds on the activity of the mitochondrial respiratory chain system.
Reward, addiction, and emotion regulation systems associated with rejection in love.
Fisher, Helen E; Brown, Lucy L; Aron, Arthur; Strong, Greg; Mashek, Debra
2010-07-01
Romantic rejection causes a profound sense of loss and negative affect. It can induce clinical depression and in extreme cases lead to suicide and/or homicide. To begin to identify the neural systems associated with this natural loss state, we used functional magnetic resonance imaging to study 10 women and 5 men who had recently been rejected by a partner but reported they were still intensely "in love." Participants alternately viewed a photograph of their rejecting beloved and a photograph of a familiar, individual, interspersed with a distraction-attention task. Their responses while looking at their rejecter included love, despair, good, and bad memories, and wondering why this happened. Activation specific to the image of the beloved occurred in areas associated with gains and losses, craving and emotion regulation and included the ventral tegmental area (VTA) bilaterally, ventral striatum, medial and lateral orbitofrontal/prefrontal cortex, and cingulate gyrus. Compared with data from happily-in-love individuals, the regional VTA activation suggests that mesolimbic reward/survival systems are involved in romantic passion regardless of whether one is happily or unhappily in love. Forebrain activations associated with motivational relevance, gain/loss, cocaine craving, addiction, and emotion regulation suggest that higher-order systems subject to experience and learning also may mediate the rejection reaction. The results show activation of reward systems, previously identified by monetary stimuli, in a natural, endogenous, negative emotion state. Activation of areas involved in cocaine addiction may help explain the obsessive behaviors associated with rejection in love.
NASA Astrophysics Data System (ADS)
Rytov, M. Yu; Leksikov, E. V.; Sakalo, V. I.; Kovalev, P. A.
2017-01-01
At the moment the domestic policy of the Russian Federation is being formed in difficult conditions of a foreign policy situation. The regional policy is built on the platform of alignment of social and economic development indices. To maintain the activity of regional social and economic systems is important for the management system of executive authorities (EA), including regional ones. To ensure feasibility of public administration, it is necessary to have vitally active social and economic systems.
MacNeill, J.H.; Estabrook, J.Y.
1960-05-10
A reactor control system including a continuous tape passing through a first coolant passageway, over idler rollers, back through another parallel passageway, and over motor-driven rollers is described. Discrete portions of fuel or poison are carried on two opposed active sections of the tape. Driving the tape in forward or reverse directions causes both active sections to be simultaneously inserted or withdrawn uniformly, tending to maintain a more uniform flux within the reactor. The system is particularly useful in mobile reactors, where reduced inertial resistance to control rod movement is important.
Evaluation of Mercury in Liquid Waste Processing Facilities - Phase I Report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jain, V.; Occhipinti, J.; Shah, H.
2015-07-01
This report provides a summary of Phase I activities conducted to support an Integrated Evaluation of Mercury in Liquid Waste System (LWS) Processing Facilities. Phase I activities included a review and assessment of the liquid waste inventory and chemical processing behavior of mercury using a system by system review methodology approach. Gaps in understanding mercury behavior as well as action items from the structured reviews are being tracked. 64% of the gaps and actions have been resolved.
Evaluation of mercury in liquid waste processing facilities - Phase I report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jain, V.; Occhipinti, J. E.; Shah, H.
2015-07-01
This report provides a summary of Phase I activities conducted to support an Integrated Evaluation of Mercury in Liquid Waste System (LWS) Processing Facilities. Phase I activities included a review and assessment of the liquid waste inventory and chemical processing behavior of mercury using a system by system review methodology approach. Gaps in understanding mercury behavior as well as action items from the structured reviews are being tracked. 64% of the gaps and actions have been resolved.
Space station definition and preliminary design, WP-01. Volume 1: Executive summary
NASA Technical Reports Server (NTRS)
Lenda, J. A.
1987-01-01
System activities are summarized and an overview of the system level engineering tasks performed are provided. Areas discussed include requirements, system test and verification, the advanced development plan, customer accommodations, software, growth, productivity, operations, product assurance and metrication. The hardware element study results are summarized. Overviews of recommended configurations are provided for the core module, the USL, the logistics elements, the propulsion subsystems, reboost, vehicle accommodations, and the smart front end. A brief overview is provided for costing activities.
Automatic lightning detection and photographic system
NASA Technical Reports Server (NTRS)
Wojtasinski, R. J.; Holley, L. D.; Gray, J. L.; Hoover, R. B. (Inventor)
1972-01-01
A system is presented for monitoring and recording lightning strokes within a predetermined area with a camera having an electrically operated shutter with means for advancing the film in the camera after activating the shutter. The system includes an antenna for sensing lightning strikes which, in turn, generates a signal that is fed to an electronic circuit which generates signals for operating the shutter of the camera. Circuitry is provided for preventing activation of the shutter as the film in the camera is being advanced.
Chairmanship of the Neptune/Pluto Outer Planets Science Working Group
NASA Technical Reports Server (NTRS)
Stern, S. Alan
1992-01-01
The Outer Planets Science Working Group (OPSWG) is the NASA Solar System Exploration Division (SSED) scientific steering committee for the Outer Solar Systems missions. The FY92 activities of OPSWG are summarized. A set of objectives for OPSWG over FY93 are described. OPSWG's activities for subsequent years are outlined. A paper which examines scientific questions motivating renewed exploration of the Neptune/Triton system and which reviews the technical results of the mission studies completed to date is included in the appendix.
Passive and Active Control of Space Structures (PACOSS)
NASA Astrophysics Data System (ADS)
Morosow, G.; Harcrow, H.; Rogers, L.
1985-04-01
Passive and Active Control of Space Structures (PACOSS) is a five-year program designed to investigate highly damped structures in conjunction with active control systems, and in particular to develop technology that integrates passive damping and active control to achieve precise pointing control. Major areas of research include metal matrix composites; viscoelastic materials; damping devices; dynamic test article design, fabrication and testing; and active damping.
Comer, Clinton S; Harrison, Patti Kelly; Harrison, David W
2015-01-01
Arousal theory as discussed within the present paper refers to those mechanisms and neural systems involved in central nervous system activation and more specifically the systems involved in cortical activation. Historical progress in the evolution of arousal theory has led to a better understanding of the functional neural systems involved in arousal or activation processes and ultimately contributed much to our current theories of emotion. Despite evidence for the dynamic interplay between the left and right cerebral hemispheres, the concepts of cerebral balance and dynamic activation have been emphasized in the neuropsychological literature. A conceptual model is proposed herein that incorporates the unique contributions from multiple neuropsychological theories of arousal and emotion. It is argued that the cerebral hemispheres may play oppositional roles in emotion partially due to the differences in their functional specializations and in their persistence upon activation. In the presence of a threat or provocation, the right hemisphere may activate survival relevant responses partially derived from hemispheric specializations in arousal and emotional processing, including the mobilization of sympathetic drive to promote heightened blood pressure, heart rate, glucose mobilization and respiratory support necessary for the challenge. Oppositional processes and mechanisms are discussed, which may be relevant to the regulatory control over the survival response; however, the capacity of these systems is necessarily limited. A limited capacity mechanism is proposed, which is familiar within other physiological systems, including that providing for the prevention of muscular damage under exceptional demand. This capacity theory is proposed, wherein a link may be expected between exceptional stress within a neural system and damage to the neural system. These mechanisms are proposed to be relevant to emotion and emotional disorders. Discussion is provided on the possible role of currently applied therapeutic interventions for emotional disorders.
A Case Study of the United States Navy’s Enterprise Resource Planning System
2006-06-01
incarnations, MRP-II added the capabilities of shop-floor management and distribution management activities. Later versions included the ability to manage ... finances , human resources, engineering, and project management. Enterprise Resource Planning systems were then developed as an integrated system
Computing and Systems Applied in Support of Coordinated Energy, Environmental, and Climate Planning
This talk focuses on how Dr. Loughlin is applying Computing and Systems models, tools and methods to more fully understand the linkages among energy systems, environmental quality, and climate change. Dr. Loughlin will highlight recent and ongoing research activities, including: ...
NASA Technical Reports Server (NTRS)
2004-01-01
KENNEDY SPACE CENTER, FLA. Activities at the One NASA Leader-Led Workshop included a panel to answer questions from the audience. Seated here are Lynn Cline, deputy associate administrator for Space Operations, Adm. Craig Steidle, associate administrator for Exploration Systems, and Woodrow Whitlow Jr., Kennedy deputy director. The workshop included senior leadership in the Agency who talked about ongoing Transformation activities and Kennedys role in the Vision for Space Exploration.
ERIC Educational Resources Information Center
Dow, Jaye
This learning packet was developed for grade 5 to teach about the geology of a park. Sections include: (1) Introduction, which introduces the North Carolina State Park System, Hanging Rock State Park, the park's activity packet, and the geology of the park; (2) Summary, a brief summary of the activity outlines including major concepts and…
A robust activity marking system for exploring active neuronal ensembles
Sørensen, Andreas T; Cooper, Yonatan A; Baratta, Michael V; Weng, Feng-Ju; Zhang, Yuxiang; Ramamoorthi, Kartik; Fropf, Robin; LaVerriere, Emily; Xue, Jian; Young, Andrew; Schneider, Colleen; Gøtzsche, Casper René; Hemberg, Martin; Yin, Jerry CP; Maier, Steven F; Lin, Yingxi
2016-01-01
Understanding how the brain captures transient experience and converts it into long lasting changes in neural circuits requires the identification and investigation of the specific ensembles of neurons that are responsible for the encoding of each experience. We have developed a Robust Activity Marking (RAM) system that allows for the identification and interrogation of ensembles of neurons. The RAM system provides unprecedented high sensitivity and selectivity through the use of an optimized synthetic activity-regulated promoter that is strongly induced by neuronal activity and a modified Tet-Off system that achieves improved temporal control. Due to its compact design, RAM can be packaged into a single adeno-associated virus (AAV), providing great versatility and ease of use, including application to mice, rats, flies, and potentially many other species. Cre-dependent RAM, CRAM, allows for the study of active ensembles of a specific cell type and anatomical connectivity, further expanding the RAM system’s versatility. DOI: http://dx.doi.org/10.7554/eLife.13918.001 PMID:27661450
NASA Technical Reports Server (NTRS)
Rupert, J. K.; Hampton, R. D.; Beech, G. S.
2005-01-01
In the late 1980s, microgravity researchers began to voice their concern that umbilical-transmitted energy could significantly degrade the acceleration environment of microgravity space science experiments onboard manned spacecraft. Since umbilicals are necessary for many experiments, control designers began to seek ways to compensate for these "indirect" disturbances. Hampton, et al., used the Kane s method to develop a model of the active rack isolation system (ARIS) that includes (1) actuator control forces, (2) direct disturbance forces, and (3) indirect, actuator-transmitted disturbances. Their model does not, however, include the indirect, umbilical-transmitted disturbances. Since the umbilical stiffnesses are not negligible, these indirect disturbances must be included in the model. Until the umbilicals have been appropriately included, the model will be incomplete. This Technical Memorandum presents a nonlinear model of ARIS with umbilicals included. Model verification was achieved by utilizing two commercial-off-the-shelf software tools. Various forces and moments were applied to the model to yield simulated responses of the system. Plots of the simulation results show how various critical points on an ARIS-outfitted international standard payload rack behave under the application of direct disturbances, indirect disturbances, and control forces. Simulations also show system response to a variety of initial conditions.
DOE Office of Scientific and Technical Information (OSTI.GOV)
West, W.S.
Progress during the period includes completion of the SNAP 7C system tests, completion of safety analysis for the SNAP 7A and C systems, assembly and initial testing of SNAP 7A, assembly of a modified reliability model, and assembly of a 10-W generator. Other activities include completion of thermal and safety analyses for SNAP 7B and D generators and fuel processing for these generators. (J.R.D.)
NASA Astrophysics Data System (ADS)
Barberis, Lucas; Peruani, Fernando
2016-12-01
We study a minimal cognitive flocking model, which assumes that the moving entities navigate using the available instantaneous visual information exclusively. The model consists of active particles, with no memory, that interact by a short-ranged, position-based, attractive force, which acts inside a vision cone (VC), and lack velocity-velocity alignment. We show that this active system can exhibit—due to the VC that breaks Newton's third law—various complex, large-scale, self-organized patterns. Depending on parameter values, we observe the emergence of aggregates or millinglike patterns, the formation of moving—locally polar—files with particles at the front of these structures acting as effective leaders, and the self-organization of particles into macroscopic nematic structures leading to long-ranged nematic order. Combining simulations and nonlinear field equations, we show that position-based active models, as the one analyzed here, represent a new class of active systems fundamentally different from other active systems, including velocity-alignment-based flocking systems. The reported results are of prime importance in the study, interpretation, and modeling of collective motion patterns in living and nonliving active systems.
Barberis, Lucas; Peruani, Fernando
2016-12-09
We study a minimal cognitive flocking model, which assumes that the moving entities navigate using the available instantaneous visual information exclusively. The model consists of active particles, with no memory, that interact by a short-ranged, position-based, attractive force, which acts inside a vision cone (VC), and lack velocity-velocity alignment. We show that this active system can exhibit-due to the VC that breaks Newton's third law-various complex, large-scale, self-organized patterns. Depending on parameter values, we observe the emergence of aggregates or millinglike patterns, the formation of moving-locally polar-files with particles at the front of these structures acting as effective leaders, and the self-organization of particles into macroscopic nematic structures leading to long-ranged nematic order. Combining simulations and nonlinear field equations, we show that position-based active models, as the one analyzed here, represent a new class of active systems fundamentally different from other active systems, including velocity-alignment-based flocking systems. The reported results are of prime importance in the study, interpretation, and modeling of collective motion patterns in living and nonliving active systems.
Potential Collaborative Research topics with Korea’s Agency for Defense Development
DOE Office of Scientific and Technical Information (OSTI.GOV)
Farrar, Charles R.; Todd, Michael D.
2012-08-23
This presentation provides a high level summary of current research activities at the Los Alamos National Laboratory (LANL)-University of California Jacobs School of Engineering (UCSD) Engineering Institute that will be presented at Korea's Agency for Defense Development (ADD). These research activities are at the basic engineering science level with different level of maturity ranging from initial concepts to field proof-of-concept demonstrations. We believe that all of these activities are appropriate for collaborative research activities with ADD subject to approval by each institution. All the activities summarized herein have the common theme that they are multi-disciplinary in nature and typically involvedmore » the integration of high-fidelity predictive modeling, advanced sensing technologies and new development in information technology. These activities include: Wireless Sensor Systems, Swarming Robot sensor systems, Advanced signal processing (compressed sensing) and pattern recognition, Model Verification and Validation, Optimal/robust sensor system design, Haptic systems for large-scale data processing, Cyber-physical security for robots, Multi-source energy harvesting, Reliability-based approaches to damage prognosis, SHMTools software development, and Cyber-physical systems advanced study institute.« less
Integrated Neural and Endocrine Control of Gastrointestinal Function.
Furness, John B
The activity of the digestive system is dynamically regulated by external factors, including body nutritional and activity states, emotions and the contents of the digestive tube. The gut must adjust its activity to assimilate a hugely variable mixture that is ingested, particularly in an omnivore such as human for which a wide range of food choices exist. It must also guard against toxins and pathogens. These nutritive and non-nutritive components of the gut contents interact with the largest and most vulnerable surface in the body, the lining of the gastrointestinal tract. This requires a gut sensory system that can detect many classes of nutrients, non-nutrient components of food, physicochemical conditions, toxins, pathogens and symbionts (Furness et al., Nat Rev Gastroenterol Hepatol 10:729-740, 2013). The gut sensors are in turn coupled to effector systems that can respond to the sensory information. The responses are exerted through enteroendocrine cells (EEC), the enteric nervous system (ENS), the central nervous system (CNS) and the gut immune and tissue defence systems. It is apparent that the control of the digestive organs is an integrated function of these effectors. The peripheral components of the EEC, ENS and CNS triumvirate are extensive. EEC cells have traditionally been classified into about 12 types (disputed in this review), releasing about 20 hormones, together making the gut endocrine system the largest endocrine organ in the body. Likewise, in human the ENS contains about 500 million neurons, far more than the number of neurons in the remainder of the peripheral autonomic nervous system. Together gut hormones, the ENS and the CNS control or influence functions including satiety, mixing and propulsive activity, release of digestive enzymes, induction of nutrient transporters, fluid transport, local blood flow, gastric acid secretion, evacuation and immune responses. Gut content receptors, including taste, free fatty acid, peptide and phytochemical receptors, are primarily located on EEC. Hormones released by EEC act via both the ENS and CNS to optimise digestion. Toxic chemicals and pathogens are sensed and then avoided, expelled or metabolised. These defensive activities also involve the EEC and signalling from EEC to the ENS and the CNS. A major challenge is to develop a comprehensive understanding of the integrated responses of the gut, via its effector systems, the ENS, extrinsic innervation, EEC and the gut immune system, to the sensory information it receives.
Rodríguez-Rodríguez, Carlos E; Castro-Gutiérrez, Víctor; Chin-Pampillo, Juan Salvador; Ruiz-Hidalgo, Karla
2013-08-01
Environmental contamination with pesticides is an undesired consequence of agricultural activities. Biopurification systems (BPS) comprise a novel strategy to degrade pesticides from contaminated wastewaters, consisting of a highly active biological mixture confined in a container or excavation. The design of BPS promotes microbial activity, in particular by white rot fungi (WRF). Due to their physiological features, specifically the production of highly unspecific ligninolytic enzymes and some intracellular enzymatic complexes, WRF show the ability to transform a wide range of organic pollutants. This minireview summarizes the potential participation of WRF in BPS. The first part presents the potential use of WRF in biodegradation of pollutants, particularly pesticides, and includes a brief description of the enzymatic systems involved in their oxidation. The second part presents an outline of BPS, focusing on the elements that influence the participation of WRF in their operation, and includes a summary of the studies regarding the fungal-mediated degradation of pesticides in BPS biomixtures and other solid-phase systems that mimic BPS. © 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.
Artificial activation of toxin-antitoxin systems as an antibacterial strategy.
Williams, Julia J; Hergenrother, Paul J
2012-06-01
Toxin-antitoxin (TA) systems are unique modules that effect plasmid stabilization via post-segregational killing of the bacterial host. The genes encoding TA systems also exist on bacterial chromosomes, and it has been speculated that these are involved in a variety of cellular processes. Interest in TA systems has increased dramatically over the past 5 years as the ubiquitous nature of TA genes on bacterial genomes has been revealed. The exploitation of TA systems as an antibacterial strategy via artificial activation of the toxin has been proposed and has considerable potential; however, efforts in this area remain in the early stages and several major questions remain. This review investigates the tractability of targeting TA systems to kill bacteria, including fundamental requirements for success, recent advances, and challenges associated with artificial toxin activation. Copyright © 2012 Elsevier Ltd. All rights reserved.
Validation of a novel mapping system and utility for mapping complex atrial tachycardias.
Honarbakhsh, S; Hunter, R J; Dhillon, G; Ullah, W; Keating, E; Providencia, R; Chow, A; Earley, M J; Schilling, R J
2018-03-01
This study sought to validate a novel wavefront mapping system utilizing whole-chamber basket catheters (CARTOFINDER, Biosense Webster). The system was validated in terms of (1) mapping atrial-paced beats and (2) mapping complex wavefront patterns in atrial tachycardia (AT). Patients undergoing catheter ablation for AT and persistent AF were included. A 64-pole-basket catheter was used to acquire unipolar signals that were processed by CARTOFINDER mapping system to generate dynamic wavefront propagation maps. The left atrium was paced from four sites to demonstrate focal activation. ATs were mapped with the mechanism confirmed by conventional mapping, entrainment, and response to ablation. Twenty-two patients were included in the study (16 with AT and 6 with AF initially who terminated to AT during ablation). In total, 172 maps were created with the mapping system. It correctly identified atrial-pacing sites in all paced maps. It accurately mapped 9 focal/microreentrant and 18 macroreentrant ATs both in the left and right atrium. A third and fourth observer independently identified the sites of atrial pacing and the AT mechanism from the CARTOFINDER maps, while being blinded to the conventional activation maps. This novel mapping system was effectively validated by mapping focal activation patterns from atrial-paced beats. The system was also effective in mapping complex wavefront patterns in a range of ATs in patients with scarred atria. The system may therefore be of practical use in the mapping and ablation of AT and could have potential for mapping wavefront activations in AF. © 2018 Wiley Periodicals, Inc.
Industrial Automation Mechanic Model Curriculum Project. Final Report.
ERIC Educational Resources Information Center
Toledo Public Schools, OH.
This document describes a demonstration program that developed secondary level competency-based instructional materials for industrial automation mechanics. Program activities included task list compilation, instructional materials research, learning activity packet (LAP) development, construction of lab elements, system implementation,…
Contingency rescheduling of spacecraft operations
NASA Technical Reports Server (NTRS)
Britt, Daniel L.; Geoffroy, Amy L.; Gohring, John R.
1988-01-01
Spacecraft activity scheduling was a focus of attention in artificial intelligence recently. Several scheduling systems were devised which more-or-less successfully address various aspects of the activity scheduling problem, though most of these are not yet mature, with the notable expection of NASA's ESP. Few current scheduling systems, however, make any attempt to deal fully with the problem of modifying a schedule in near-real-time in the event of contingencies which may arise during schedule execution. These contingencies can include resources becoming unavailable unpredictably, a change in spacecraft conditions or environment, or the need to perform an activity not scheduled. In these cases it becomes necessary to repair an existing schedule, disrupting ongoing operations as little as possible. Normal scheduling is just a part of that which must be accomplished during contingency rescheduling. A prototype system named MAESTRO was developed for spacecraft activity scheduling. MAESTRO is briefly described with a focus on recent work in the area of real-time contingency handling. Included is a discussion of some of the complexities of the scheduling problem and how they affect contingency rescheduling, such as temporal constraints between activities, activities which may be interrupted and continued in any of several ways, and different ways to choose a resource complement which will allow continuation of an activity. Various heuristics used in MAESTRO for contingency rescheduling is discussed, as are operational concerns such as interaction of the scheduler with spacecraft subsystems controllers.
International Space Station Instmments Collect Imagery of Natural Disasters
NASA Technical Reports Server (NTRS)
Evans, C. A.; Stefanov, W. L.
2013-01-01
A new focus for utilization of the International Space Station (ISS) is conducting basic and applied research that directly benefits Earth's citizenry. In the Earth Sciences, one such activity is collecting remotely sensed imagery of disaster areas and making those data immediately available through the USGS Hazards Data Distribution System, especially in response to activations of the International Charter for Space and Major Disasters (known informally as the "International Disaster Charter", or IDC). The ISS, together with other NASA orbital sensor assets, responds to IDC activations following notification by the USGS. Most of the activations are due to natural hazard events, including large floods, impacts of tropical systems, major fires, and volcanic eruptions and earthquakes. Through the ISS Program Science Office, we coordinate with ISS instrument teams for image acquisition using several imaging systems. As of 1 August 2013, we have successfully contributed imagery data in support of 14 Disaster Charter Activations, including regions in both Haiti and the east coast of the US impacted by Hurricane Sandy; flooding events in Russia, Mozambique, India, Germany and western Africa; and forest fires in Algeria and Ecuador. ISS-based sensors contributing data include the Hyperspectral Imager for the Coastal Ocean (HICO), the ISERV (ISS SERVIR Environmental Research and Visualization System) Pathfinder camera mounted in the US Window Observational Research Facility (WORF), the ISS Agricultural Camera (ISSAC), formerly operating from the WORF, and high resolution handheld camera photography collected by crew members (Crew Earth Observations). When orbital parameters and operations support data collection, ISS-based imagery adds to the resources available to disaster response teams and contributes to the publicdomain record of these events for later analyses.
NOAA Climate Program Office Contributions to National ESPC
NASA Astrophysics Data System (ADS)
Higgins, W.; Huang, J.; Mariotti, A.; Archambault, H. M.; Barrie, D.; Lucas, S. E.; Mathis, J. T.; Legler, D. M.; Pulwarty, R. S.; Nierenberg, C.; Jones, H.; Cortinas, J. V., Jr.; Carman, J.
2016-12-01
NOAA is one of five federal agencies (DOD, DOE, NASA, NOAA, and NSF) which signed an updated charter in 2016 to partner on the National Earth System Prediction Capability (ESPC). Situated within NOAA's Office of Oceanic and Atmospheric Research (OAR), NOAA Climate Program Office (CPO) programs contribute significantly to the National ESPC goals and activities. This presentation will provide an overview of CPO contributions to National ESPC. First, we will discuss selected CPO research and transition activities that directly benefit the ESPC coupled model prediction capability, including The North American Multi-Model Ensemble (NMME) seasonal prediction system The Subseasonal Experiment (SubX) project to test real-time subseasonal ensemble prediction systems. Improvements to the NOAA operational Climate Forecast System (CFS), including software infrastructure and data assimilation. Next, we will show how CPO's foundational research activities are advancing future ESPC capabilities. Highlights will include: The Tropical Pacific Observing System (TPOS) to provide the basis for predicting climate on subseasonal to decadal timescales. Subseasonal-to-Seasonal (S2S) processes and predictability studies to improve understanding, modeling and prediction of the MJO. An Arctic Research Program to address urgent needs for advancing monitoring and prediction capabilities in this major area of concern. Advances towards building an experimental multi-decadal prediction system through studies on the Atlantic Meridional Overturning Circulation (AMOC). Finally, CPO has embraced Integrated Information Systems (IIS's) that build on the innovation of programs such as the National Integrated Drought Information System (NIDIS) to develop and deliver end to end environmental information for key societal challenges (e.g. extreme heat; coastal flooding). These contributions will help the National ESPC better understand and address societal needs and decision support requirements.
Space and Missile Systems Center Standard: Software Development
2015-01-16
maintenance , or any other activity or combination of activities resulting in products . Within this standard, requirements to “develop,” “define...integration, reuse, reengineering, maintenance , or any other activity that results in products ). The term “developer” encompasses all software team...activities that results in software products . Software development includes new development, modification, reuse, reengineering, maintenance , and any other
Delivery Systems for Birch-Bark Triterpenoids and Their Derivatives in Anticancer Research.
Mierina, Inese; Vilskersts, Reinis; Turks, Maris
2018-05-29
Birch-bark triterpenoids and their semi-synthetic derivatives possess a wide range of biological activities including cytotoxic effects on various tumour cell lines. However, due to the low solubility and bioavailability, their medicinal applications are rather limited. The use of various nanotechnology-based drug delivery systems is rapidly developing approach to the solubilisation of insufficiently bioavailable pharmaceuticals. Herein, the drug delivery systems deemed to be applicable for birch-bark triterpenoid structures are reviewed. The aforementioned disadvantages of birch-bark triterpenoids and their semi-synthetic derivatives can be overcome through their incorporation into organic nanoparticles, which include various dendrimeric systems, as well as embedding the active compounds into polymer matrices or complexation with carbohydrate nanoparticles without covalent bonding. Some of the known triterpenoid delivery systems consist of nanoparticles featuring inorganic cores covered with carbohydrates or other polymers. Methods for delivering the title compounds through encapsulation and emulsification into lipophilic media are also suitable. Besides, the birch-bark triterpenoids can form self-assembling systems with increased bio-availability. Even more, the self-assembling systems are used as carriers for delivering other chemotherapeutic agents. Another advantage besides increased bioavailability and anticancer activity is the reduced overall systemic toxicity in most of the cases, when triterpenoids are delivered with any of the carriers. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
77 FR 58814 - Privacy Act of 1974 System of Records Notice
Federal Register 2010, 2011, 2012, 2013, 2014
2012-09-24
... revises the description of the system and enhancements to more broadly cover the Commission's market oversight, and market, risk and financial surveillance activities. The data covered by this expanded system includes records required to monitor the commodity futures and swaps markets, perform various mission...
Networking and Microcomputers. ERIC Digest.
ERIC Educational Resources Information Center
Klausmeier, Jane
Computer networks can fall into three broad categories--local area networks (LAN), microcomputer based messaging systems (this includes computer bulletin board systems), or commercial information systems. Many of the same types of activities take place within the three categories. The major differences are the types of information available and…
76 FR 43937 - Criminal Penalties for Unauthorized Introduction of Weapons and Sabotage
Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-22
..., Rockville, Maryland 20852. NRC's Agencywide Documents Access and Management System (ADAMS): Publicly... from which a radiological emergency preparedness alert and warning system is activated. II. Discussion... nationally tracked sources that are included in the NRC's National Source Tracking System (i.e., licensees...
Reversible and dissipative macroscopic contributions to the stress tensor: active or passive?
Brand, H R; Pleiner, H; Svenšek, D
2014-09-01
The issue of dynamic contributions to the macroscopic stress tensor has been of high interest in the field of bio-inspired active systems over the last few years. Of particular interest is a direct coupling ("active term") of the stress tensor with the order parameter, the latter describing orientational order induced by active processes. Here we analyze more generally possible reversible and irreversible dynamic contributions to the stress tensor for various passive and active macroscopic systems. This includes systems with tetrahedral/octupolar order, polar and non-polar (chiral) nematic and smectic liquid crystals, as well as active fluids with a dynamic preferred (polar or non-polar) direction. We show that it cannot a priori be seen, neither from the symmetry properties of the macroscopic variables involved, nor from the structure of the cross-coupling contributions to the stress tensor, whether the system studied is active or passive. Rather, that depends on whether the variables that give rise to those cross-couplings in the stress tensor are driven or not. We demonstrate that several simplified descriptions of active systems in the literature that neglect the necessary counter term to the active term violate linear irreversible thermodynamics and lead to an unphysical contribution to the entropy production.
Modulation of the mirror system by social relevance.
Kilner, James M; Marchant, Jennifer L; Frith, Chris D
2006-09-01
When we observe the actions of others, certain areas of the brain are activated in a similar manner as to when we perform the same actions ourselves. This 'mirror system' includes areas in the ventral premotor cortex and the inferior parietal lobule. Experimental studies suggest that action observation automatically elicits activity in the observer, which precisely mirrors the activity observed. In this case we would expect this activity to be independent of observer's viewpoint. Here we use whole-head magnetoencephalography (MEG) to record cortical activity of human subjects whilst they watched a series of videos of an actor making a movement recorded from different viewpoints. We show that one cortical response to action observation (oscillatory activity in the 7-12 Hz frequency range) is modulated by the relationship between the observer and the actor. We suggest that this modulation reflects a mechanism that filters information into the 'mirror system', allowing only socially relevant information to pass.
Chang, Hoo-Sun
2012-01-01
On July 23rd, 2010 a revised medical law (Article 58) was passed to change existing evaluation system of medical institutions to an accreditation system. The new healthcare accreditation system was introduced to encourage medical institutions to work voluntarily and continuously to improve patient safety and medical service quality. Changes regarding the healthcare accreditation system included the establishment of an accreditation agency, the voluntary participation of medical institutions, accreditation standards centering on the treatment process and patient safety, tracing methodology, and the announcement of comprehensive results concerning accreditation. Despite varying views on the healthcare accreditation system, including some that are critical, it is meaningful that the voluntary nature of the system acknowledges that the medical institutions must be active agents in improving medical service quality. Healthcare quality is not improved instantaneously, but instead gradually through continuous communication within the clinical field. For this accreditation system to be successful, followings are essential: the accreditation agency becomes financially independent and is managed efficiently, the autonomy and regulation surrounding the system are balanced, the professionalism of the system is ensured, and the medical field plays an active role in the operation of the system. PMID:22661873
Treatment of industrial effluents by a continuous system: electrocoagulation--activated sludge.
Moisés, Tejocote-Pérez; Patricia, Balderas-Hernández; Barrera-Díaz, C E; Gabriela, Roa-Morales; Natividad-Rangel, Reyna
2010-10-01
A continuous system electrocoagulation--active sludge was designed and built for the treatment of industrial wastewater. The system included an electrochemical reactor with aluminum electrodes, a clarifier and a biological reactor. The electrochemical reactor was tested under different flowrates (50, 100 and 200 mL/min). In the biological reactor, the performance of different cultures of active sludge was assessed: coliform bacterial, ciliate and flagellate protozoa and aquatic fungus. Overall treatment efficiencies of color, turbidity and COD removal were 94%, 92% and 80%, respectively, under optimal conditions of 50 mL/min flowrate and using ciliate and flagellate protozoa. It was concluded that the system was efficient for the treatment of industrial wastewater. Copyright © 2010 Elsevier Ltd. All rights reserved.
17 CFR 240.3b-15 - Definition of ancillary portfolio management securities activities.
Code of Federal Regulations, 2010 CFR
2010-04-01
... governing body of the dealer and included in the internal risk management control system for the dealer... of incidental trading activities for portfolio management purposes; and (3) Are limited to risk... portfolio management securities activities. 240.3b-15 Section 240.3b-15 Commodity and Securities Exchanges...
Ecology of an Estuary: Chesapeake Bay. A Guide for Middle School Teachers.
ERIC Educational Resources Information Center
Fleming, Cris; Swarth, Christopher
This environmental education teaching guide for middle school teachers features information on the National Estuarine Reserve System in Maryland. Pre-trip field activities, field trip activities, and post-trip activities are discussed, and a list of useful resources and organizations is provided. Reproducible handouts are included throughout the…
Active Life of the Senior Citizens through Education
ERIC Educational Resources Information Center
Taziev, Saljakhutdin Fardievich
2015-01-01
The paper presents reasons for including the senior citizens into educational process, as well as active age model. Education, communication and leisure system for the senior citizens, implemented by Yelabuga municipal district, is presented as a requirement for model realization. A core of the paper is the Active Age Institute. Its program…
The Road to Computer Literacy. Part V: Objectives and Activities for Grades 10-12.
ERIC Educational Resources Information Center
Bitter, Gary
1983-01-01
Presents computer-oriented activities in computer awareness and programing for students in grades 10-12. Intended for use by teachers of all disciplines, activities include such topics as prediction, interpretation and generalization of data, computer systems, PASCAL and PILOT programing, sampling techniques, computer survival, invasion of…
MSFC Skylab neutral buoyancy simulator
NASA Technical Reports Server (NTRS)
1974-01-01
The use of a neutral buoyancy simulator for developing extravehicular activity systems and for training astronauts in weightless activities is discussed. The construction of the facility and the operations are described. The types of tests and the training activities conducted in the simulator are reported. Photographs of the components of the simulator and actual training exercises are included.
Software Development Standard for Mission Critical Systems
2014-03-17
new development, modification, reuse, reengineering, maintenance , or any other activity or combination of activities resulting in products . Within...develops” includes new development, modification, integration, reuse, reengineering, maintenance , or any other activity that results in products ... Maintenance organization. The organization that is responsible for modifying and otherwise sustaining the software and other software products and
de Almeida, C M; da Rosa, W L O; Meereis, C T W; de Almeida, S M; Ribeiro, J S; da Silva, A F; Lund, Rafael Guerra
2018-06-01
The purpose of this study was to evaluate the efficacy of orthodontic bonding systems containing different antimicrobial agents, as well as the influence of antimicrobial agent incorporation in the bonding properties of these materials. Eight databases were searched: PubMed (Medline), Web of Science, Scopus, Lilacs, Ibecs, BBO, Scielo and Google Scholar. Any study that evaluated antimicrobial activity in experimental or commercial orthodontic bonding systems was included. Data were tabulated independently and in duplicated by two authors on pre-designed data collection form. The global analysis was carried out using a random-effects model, and pooled-effect estimates were obtained by comparing the standardised mean difference of each antimicrobial orthodontic adhesive with the respective control group. A p-value < .05 was considered as statistically significant. Thirty-two studies were included in the qualitative analysis; of these, 22 studies were included in the meta-analysis. Antimicrobial agents such as silver nanoparticles, benzalkonium chloride, chlorhexidine, triclosan, cetylpyridinium chloride, Galla chinensis extract, acid ursolic, dimethylaminododecyl methacrylate, dimethylaminohexadecyl methacrylate, 2-methacryloyloxyethyl phosphorylcholine, 1,3,5-triacryloylhexahydro-1,3,5-triazine, zinc oxide and titanium oxide have been incorporated into orthodontic bonding systems. The antimicrobial agent incorporation in orthodontic bonding systems showed higher antimicrobial activity than the control group in agar diffusion (overall standardised mean difference: 3.71; 95% CI 2.98 to 4.43) and optical density tests (0.41; 95% CI -0.05 to 0.86) (p < .05). However, for biofilm, the materials did not present antimicrobial activity (6.78; 95% CI 4.78 to 8.77). Regarding bond strength, the global analysis showed antimicrobial orthodontic bonding systems were statistically similar to the control. Although there is evidence of antibacterial activity from in vitro studies, clinical and long-term studies are still necessary to confirm the effectiveness of antibacterial orthodontic bonding systems in preventing caries disease.
EVA Roadmap: New Space Suit for the 21st Century
NASA Technical Reports Server (NTRS)
Yowell, Robert
1998-01-01
New spacesuit design considerations for the extra vehicular activity (EVA) of a manned Martian exploration mission are discussed. Considerations of the design includes:(1) regenerable CO2 removal, (2) a portable life support system (PLSS) which would include cryogenic oxygen produced from in-situ manufacture, (3) a power supply for the EVA, (4) the thermal control systems, (5) systems engineering, (5) space suit systems (materials, and mobility), (6) human considerations, such as improved biomedical sensors and astronaut comfort, (7) displays and controls, and robotic interfaces, such as rovers, and telerobotic commands.
NASA Technical Reports Server (NTRS)
Bains, R. W.; Herwig, H. A.; Luedeman, J. K.; Torina, E. M.
1974-01-01
The Shuttle Electric Power System Analysis SEPS computer program which performs detailed load analysis including predicting energy demands and consumables requirements of the shuttle electric power system along with parameteric and special case studies on the shuttle electric power system is described. The functional flow diagram of the SEPS program is presented along with data base requirements and formats, procedure and activity definitions, and mission timeline input formats. Distribution circuit input and fixed data requirements are included. Run procedures and deck setups are described.
Wilson, Dawn K.; St. George, Sara M.; Lawman, Hannah; Segal, Michelle; Fairchild, Amanda
2012-01-01
Rates of overweight in youth have reached epidemic proportions and are associated with adverse health outcomes. Family-based programs have been widely used to treat overweight in youth. However, few programs incorporate a theoretical framework for studying a family systems approach in relation to youth health behavior change. Therefore, this review provides a family systems theory framework for evaluating family-level variables in weight loss, physical activity, and dietary approaches in youth. Studies were reviewed and effect sizes were calculated for interventions that manipulated the family system, including components that targeted parenting styles, parenting skills, or family functioning, or which had novel approaches for including the family. Twenty-one weight loss interventions were identified, and 25 interventions related to physical activity and/or diet were identified. Overall, family-based treatment programs that incorporated training for authoritative parenting styles, parenting skills, or child management, and family functioning had positive effects on youth weight loss. Programs to improve physical activity and dietary behaviors that targeted the family system also demonstrated improvements in youth health behaviors; however, direct effects of parent-targeted programming is not clear. Both treatment and prevention programs would benefit from evaluating family functioning and parenting styles as possible mediators of intervention outcomes. Recommendations are provided to guide the development of future family-based obesity prevention and treatment programs for youth. PMID:20689989
Airborne laser sensors and integrated systems
NASA Astrophysics Data System (ADS)
Sabatini, Roberto; Richardson, Mark A.; Gardi, Alessandro; Ramasamy, Subramanian
2015-11-01
The underlying principles and technologies enabling the design and operation of airborne laser sensors are introduced and a detailed review of state-of-the-art avionic systems for civil and military applications is presented. Airborne lasers including Light Detection and Ranging (LIDAR), Laser Range Finders (LRF), and Laser Weapon Systems (LWS) are extensively used today and new promising technologies are being explored. Most laser systems are active devices that operate in a manner very similar to microwave radars but at much higher frequencies (e.g., LIDAR and LRF). Other devices (e.g., laser target designators and beam-riders) are used to precisely direct Laser Guided Weapons (LGW) against ground targets. The integration of both functions is often encountered in modern military avionics navigation-attack systems. The beneficial effects of airborne lasers including the use of smaller components and remarkable angular resolution have resulted in a host of manned and unmanned aircraft applications. On the other hand, laser sensors performance are much more sensitive to the vagaries of the atmosphere and are thus generally restricted to shorter ranges than microwave systems. Hence it is of paramount importance to analyse the performance of laser sensors and systems in various weather and environmental conditions. Additionally, it is important to define airborne laser safety criteria, since several systems currently in service operate in the near infrared with considerable risk for the naked human eye. Therefore, appropriate methods for predicting and evaluating the performance of infrared laser sensors/systems are presented, taking into account laser safety issues. For aircraft experimental activities with laser systems, it is essential to define test requirements taking into account the specific conditions for operational employment of the systems in the intended scenarios and to verify the performance in realistic environments at the test ranges. To support the development of such requirements, useful guidelines are provided for test and evaluation of airborne laser systems including laboratory, ground and flight test activities.
Space Construction System Analysis. Part 2: Executive summary
NASA Technical Reports Server (NTRS)
1980-01-01
A detailed, end-to-end analysis of the activities, techniques, equipment and Shuttle provisions required to construct a reference project system is described. Included are: platform definition; construction analysis; cost and programmatics; and space construction experiments concepts.
The Telecommunications and Data Acquisition Report
NASA Technical Reports Server (NTRS)
Posner, Edward C. (Editor)
1991-01-01
This quarterly publication provides archival reports on developments in programs managed by JPL's Office of Telecommunications and Data Acquisition (TDA). In space communications, radio navigation, radio science, and ground-based radio and radar astronomy, it reports on activities of the Deep Space Network (DSN). Also included is standards activity at JPL for space data and information systems and reimbursable DSN work performed for other space agencies through NASA. In the search for extraterrestrial intelligence (SETI), 'The TDA Progress Report' reports on implementation and operations for searching the microwave spectrum. In solar system radar, it reports on the uses of the Goldstone Solar System Radar for scientific exploration of the planets, their rings and satellites, asteroids, and comets. In radio astronomy, the areas of support include spectroscopy, very long baseline interferometry, and astrometry.
The new Euskalmet coastal-maritime warning system
NASA Astrophysics Data System (ADS)
Gaztelumendi, Santiago; Egaña, Joseba; Liria, Pedro; Gonzalez, Manuel; Aranda, José Antonio; Anitua, Pedro
2016-06-01
This work presents the main characteristics of the Basque Meteorology Agency (Euskalmet) maritime-coastal risk warning system, with special emphasis on the latest updates, including a clear differentiation on specific warning messages addressing sea conditions for navigation purposes in the first 2 nautical miles, and expected coastal impacts. Some details of the warning bulletin for maritime and coastal risk situations are also presented, together with other communication products and strategies used in coastal and maritime severe episodes at the Basque coast. Today, three different aspects are included in the coastal-maritime risk warning system in Basque Country, related to the main potential severe events that affecting coastal activities. - "Galerna" risk relates to a sudden wind reversal that can severely affect coastal navigation and recreational activities. - "Navigation" risk relates to severe sea state conditions for 0-2 miles, affecting different navigation activities. - "Coastal impact" risk relates to adverse wave characteristics and tidal surges that induce flooding events and different impacts in littoral areas.
Vollhardt, K. Peter C.; Segalman, Rachel A; Majumdar, Arunava; Meier, Steven
2015-02-10
A system for converting solar energy to chemical energy, and, subsequently, to thermal energy includes a light-harvesting station, a storage station, and a thermal energy release station. The system may include additional stations for converting the released thermal energy to other energy forms, e.g., to electrical energy and mechanical work. At the light-harvesting station, a photochemically active first organometallic compound, e.g., a fulvalenyl diruthenium complex, is exposed to light and is photochemically converted to a second, higher-energy organometallic compound, which is then transported to a storage station. At the storage station, the high-energy organometallic compound is stored for a desired time and/or is transported to a desired location for thermal energy release. At the thermal energy release station, the high-energy organometallic compound is catalytically converted back to the photochemically active organometallic compound by an exothermic process, while the released thermal energy is captured for subsequent use.
Supersonic cruise research aircraft structural studies: Methods and results
NASA Technical Reports Server (NTRS)
Sobieszczanski-Sobieski, J.; Gross, D.; Kurtze, W.; Newsom, J.; Wrenn, G.; Greene, W.
1981-01-01
NASA Langley Research Center SCAR in-house structural studies are reviewed. In methods development, advances include a new system of integrated computer programs called ISSYS, progress in determining aerodynamic loads and aerodynamically induced structural loads (including those due to gusts), flutter optimization for composite and metal airframe configurations using refined and simplified mathematical models, and synthesis of active controls. Results given address several aspects of various SCR configurations. These results include flutter penalties on composite wing, flutter suppression using active controls, roll control effectiveness, wing tip ground clearance, tail size effect on flutter, engine weight and mass distribution influence on flutter, and strength and flutter optimization of new configurations. The ISSYS system of integrated programs performed well in all the applications illustrated by the results, the diversity of which attests to ISSYS' versatility.
The simulation study on optical target laser active detection performance
NASA Astrophysics Data System (ADS)
Li, Ying-chun; Hou, Zhao-fei; Fan, Youchen
2014-12-01
According to the working principle of laser active detection system, the paper establishes the optical target laser active detection simulation system, carry out the simulation study on the detection process and detection performance of the system. For instance, the performance model such as the laser emitting, the laser propagation in the atmosphere, the reflection of optical target, the receiver detection system, the signal processing and recognition. We focus on the analysis and modeling the relationship between the laser emitting angle and defocus amount and "cat eye" effect echo laser in the reflection of optical target. Further, in the paper some performance index such as operating range, SNR and the probability of the system have been simulated. The parameters including laser emitting parameters, the reflection of the optical target and the laser propagation in the atmosphere which make a great influence on the performance of the optical target laser active detection system. Finally, using the object-oriented software design methods, the laser active detection system with the opening type, complete function and operating platform, realizes the process simulation that the detection system detect and recognize the optical target, complete the performance simulation of each subsystem, and generate the data report and the graph. It can make the laser active detection system performance models more intuitive because of the visible simulation process. The simulation data obtained from the system provide a reference to adjust the structure of the system parameters. And it provides theoretical and technical support for the top level design of the optical target laser active detection system and performance index optimization.
Isolation of Nicotinic Acid (Vitamin B3) and N-Propylamine after Myosmine Peroxidation.
Zwickenpflug, Wolfgang; Högg, Christof; Feierfeil, Johannes; Dachs, Manuel; Gudermann, Thomas
2016-01-13
The alkaloid myosmine (3-(1-pyrroline-2-yl)pyridine) is widespread in biological matrixes including foodstuffs and tobacco products. Some in vitro tests in cellular systems showed mutagenic activity for myosmine. Myosmine activation including peroxidation mechanism employs unstable oxazirane intermediates. The formation of minor metabolite 3-hydroxymethyl-pyridine in rat metabolism experiments as well as in in vitro peroxidation assays suggests its further oxidation to nicotinic acid and possible concomitant formation of n-propylamine. A sensitive high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed for the direct analysis of n-propylamine in the peroxidation assay solution of myosmine employing derivatization with 3,5-dinitrobenzoyl chloride. Additionally, during peroxidation procedures, formation of 3-pyridylmethanol to nicotinic acid, the essential vitamin B3, was observed and characterized using HPLC-UV and gas chromatography/mass spectrometry. This new reaction pathway may present further contribution to our knowledge of myosmine's significance in human food including its activation in human organism, foodstuffs, and biological systems.
Rap G protein signal in normal and disordered lymphohematopoiesis
DOE Office of Scientific and Technical Information (OSTI.GOV)
Minato, Nagahiro, E-mail: minato@imm.med.kyoto-u.ac.jp
2013-09-10
Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins including guanine nucleotide exchange factors and GTPase-activating proteins. Beyond cell biological studies, increasing attempts have been made in the past decade to define the roles of Rap signal in specific functions of normal tissue systems as well as in cancer. In the immune and hematopoietic systems, Rap signal plays crucial roles in the developmentmore » and function of essentially all lineages of lymphocytes and hematopoietic cells, and importantly, deregulated Rap signal may lead to unique pathological conditions depending on the affected cell types, including various types of leukemia and autoimmunity. The phenotypical studies have unveiled novel, even unexpected functional aspects of Rap signal in cells from a variety of tissues, providing potentially important clues for controlling human diseases, including malignancy.« less
Yuliana, Tri; Ebihara, Kyota; Suzuki, Mio; Shimonaka, Chie; Amachi, Seigo
2015-12-01
Alphaproteobacterium strain Q-1 produces an extracellular multicopper oxidase (IOX), which catalyzes iodide (I-) oxidation to form molecular iodine (I2). In this study, the antimicrobial activity of the IOX/iodide system was determined. Both Gram-positive and Gram-negative bacteria tested were killed completely within 5 min by 50 mU mL(-1) of IOX and 10 mM iodide. The sporicidal activity of the system was also tested and compared with a common iodophor, povidone-iodine (PVP-I). IOX (300 mU mL(-1)) killed Bacillus cereus, B. subtilis, and Geobacillus stearothermophilus spores with decimal reduction times of 2.58, 7.62, and 40.9 min, respectively. However, 0.1% PVP-I killed these spores with much longer decimal reduction times of 5.46, 38.0, and 260 min, respectively. To evaluate the more superior sporicidal activity of the IOX system over PVP-I, the amount of free iodine (non-complexed I2) was determined by an equilibrium dialysis technique. The IOX system included more than 40 mg L(-1) of free iodine, while PVP-I included at most 25 mg L(-1) free iodine. Our results suggest that the new enzyme-based antimicrobial system is effective against a wide variety of microorganisms and bacterial spores, and that its strong biocidal activity is due to its high free iodine content, which is probably maintained by re-oxidation of iodide released after oxidation of cell components by I2.
NASA Astrophysics Data System (ADS)
Gottwald, Martin; Mayekar, Kavita; Reiswich, Vladislav; Bousack, Herbert; Damalla, Deepak; Biswas, Shubham; Metzen, Michael G.; von der Emde, Gerhard
2011-04-01
During their nocturnal activity period, weakly electric fish employ a process called "active electrolocation" for navigation and object detection. They discharge an electric organ in their tail, which emits electrical current pulses, called electric organ discharges (EOD). Local EODs are sensed by arrays of electroreceptors in the fish's skin, which respond to modulations of the signal caused by nearby objects. Fish thus gain information about the size, shape, complex impedance and distance of objects. Inspired by these remarkable capabilities, we have designed technical sensor systems which employ active electrolocation to detect and analyse the walls of small, fluid filled pipes. Our sensor systems emit pulsed electrical signals into the conducting medium and simultaneously sense local current densities with an array of electrodes. Sensors can be designed which (i) analyse the tube wall, (ii) detect and localize material faults, (iii) identify wall inclusions or objects blocking the tube (iv) and find leakages. Here, we present first experiments and FEM simulations on the optimal sensor arrangement for different types of sensor systems and different types of tubes. In addition, different methods for sensor read-out and signal processing are compared. Our biomimetic sensor systems promise to be relatively insensitive to environmental disturbances such as heat, pressure, turbidity or muddiness. They could be used in a wide range of tubes and pipes including water pipes, hydraulic systems, and biological systems. Medical applications include catheter based sensors which inspect blood vessels, urethras and similar ducts in the human body.
Controlling Distributed Planning
NASA Technical Reports Server (NTRS)
Clement, Bradley; Barrett, Anthony
2004-01-01
A system of software implements an extended version of an approach, denoted shared activity coordination (SHAC), to the interleaving of planning and the exchange of plan information among organizations devoted to different missions that normally communicate infrequently except that they need to collaborate on joint activities and/or the use of shared resources. SHAC enables the planning and scheduling systems of the organizations to coordinate by resolving conflicts while optimizing local planning solutions. The present software provides a framework for modeling and executing communication protocols for SHAC. Shared activities are represented in each interacting planning system to establish consensus on joint activities or to inform the other systems of consumption of a common resource or a change in a shared state. The representations of shared activities are extended to include information on (1) the role(s) of each participant, (2) permissions (defined as specifications of which participant controls what aspects of shared activities and scheduling thereof), and (3) constraints on the parameters of shared activities. Also defined in the software are protocols for changing roles, permissions, and constraints during the course of coordination and execution.
L.-H. Huang, Christopher; Fraser, James A.
2011-01-01
Skeletal muscle activation requires action potential (AP) initiation followed by its sarcolemmal propagation and tubular excitation to trigger Ca2+ release and contraction. Recent studies demonstrate that ion channels underlying the resting membrane conductance (GM) of fast-twitch mammalian muscle fibers are highly regulated during muscle activity. Thus, onset of activity reduces GM, whereas prolonged activity can markedly elevate GM. Although these observations implicate GM regulation in control of muscle excitability, classical theoretical studies in un-myelinated axons predict little influence of GM on membrane excitability. However, surface membrane morphologies differ markedly between un-myelinated axons and muscle fibers, predominantly because of the tubular (t)-system of muscle fibers. This study develops a linear circuit model of mammalian muscle fiber and uses this to assess the role of subthreshold electrical properties, including GM changes during muscle activity, for AP initiation, AP propagation, and t-system excitation. Experimental observations of frequency-dependent length constant and membrane-phase properties in fast-twitch rat fibers could only be replicated by models that included t-system luminal resistances. Having quantified these resistances, the resulting models showed enhanced conduction velocity of passive current flow also implicating elevated AP propagation velocity. Furthermore, the resistances filter passive currents such that higher frequency current components would determine sarcolemma AP conduction velocity, whereas lower frequency components excite t-system APs. Because GM modulation affects only the low-frequency membrane impedance, the GM changes in active muscle would predominantly affect neuromuscular transmission and low-frequency t-system excitation while exerting little influence on the high-frequency process of sarcolemmal AP propagation. This physiological role of GM regulation was increased by high Cl− permeability, as in muscle endplate regions, and by increased extracellular [K+], as observed in working muscle. Thus, reduced GM at the onset of exercise would enhance t-system excitation and neuromuscular transmission, whereas elevated GM after sustained activity would inhibit these processes and thereby accentuate muscle fatigue. PMID:21670208
Instrumentation of sampling aircraft for measurement of launch vehicle effluents
NASA Technical Reports Server (NTRS)
Wornom, D. E.; Woods, D. C.; Thomas, M. E.; Tyson, R. W.
1977-01-01
An aircraft was selected and instrumented to measure effluents emitted from large solid propellant rockets during launch activities. The considerations involved in aircraft selection, sampling probes, and instrumentation are discussed with respect to obtaining valid airborne measurements. Discussions of the data acquisition system used, the instrument power system, and operational sampling procedures are included. Representative measurements obtained from an actual rocket launch monitoring activity are also presented.
DOT National Transportation Integrated Search
2008-12-01
Programmable logic controllers (PLCs) were installed at several key ramps with the assistance of the City of Portland and used to capture additional data about ramp operations that are not otherwise logged. The data include the activation and deactiv...
ERIC Educational Resources Information Center
Segalen, Aurore; And Others
1994-01-01
Four ideas for French language classroom activities include an exercise in the use of past tense in narrative, a children's vocabulary game, an introduction to the language of economics, and an activity combining self-expression and cultural awareness through photographs. (MSE)
Flight Dynamics Simulation Modeling and Control of a Large Flexible Tiltrotor Aircraft
2014-09-01
matrix from fixed to rotating coordinate systems u longitudinal aircraft velocity, state-space control vector v elastic beam chordwise displacement /lateral...spectrum active control , including flight control systems, rotor load limiting, and vibration and noisetiltion [1]. The development of a high-order...the flutter response of fixed- wing aircraft. The B-52 CCV ( Controls Configured Vehicle) was one of the first aircraft to demonstrate benefits of active
The U.S. Air Force Transformation Flight Plan
2003-11-01
at Buckley Air Force Base, Colorado. Reserve Associate and Active Associate units have proven that this concept works and benef its the Active and...munitions manufactured from nano-particles, whose virtually all-surface structure yields unprecedented “burn-rates” (extreme explosiveness), promise far...systems for a common operating system, and a suite of remotely operated sensors, weapons, and robotics . Also included are a group of non-lethal weapon
Active Control of a Pneumatic Isolation System,
A pneumatically isolated test platform has been modified to provide active control to the local gravity vector. A combination of sensors , including... tiltmeters , angular accelerometers, seismometers, and a gyrocompass measure total platform motion between 0 and 100 Hz. Electrical-to-pressure
Code of Federal Regulations, 2011 CFR
2011-07-01
... retain environmental analyses and data from requirements determination activities, and Science and... environmental analysis of acquisition life-cycle activities (including disposal). Planning to accomplish these... required, throughout the life cycle of the system. The MATDEV will coordinate with ASA (AL&T) or MACOM...
Spatially resolved thermal desorption/ionization coupled with mass spectrometry
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jesse, Stephen; Van Berkel, Gary J; Ovchinnikova, Olga S
2013-02-26
A system and method for sub-micron analysis of a chemical composition of a specimen are described. The method includes providing a specimen for evaluation and a thermal desorption probe, thermally desorbing an analyte from a target site of said specimen using the thermally active tip to form a gaseous analyte, ionizing the gaseous analyte to form an ionized analyte, and analyzing a chemical composition of the ionized analyte. The thermally desorbing step can include heating said thermally active tip to above 200.degree. C., and positioning the target site and the thermally active tip such that the heating step forms themore » gaseous analyte. The thermal desorption probe can include a thermally active tip extending from a cantilever body and an apex of the thermally active tip can have a radius of 250 nm or less.« less
Neural net controlled tag gas sampling system for nuclear reactors
Gross, Kenneth C.; Laug, Matthew T.; Lambert, John D. B.; Herzog, James P.
1997-01-01
A method and system for providing a tag gas identifier to a nuclear fuel rod and analyze escaped tag gas to identify a particular failed nuclear fuel rod. The method and system include disposing a unique tag gas composition into a plenum of a nuclear fuel rod, monitoring gamma ray activity, analyzing gamma ray signals to assess whether a nuclear fuel rod has failed and is emitting tag gas, activating a tag gas sampling and analysis system upon sensing tag gas emission from a failed nuclear rod and evaluating the escaped tag gas to identify the particular failed nuclear fuel rod.
Ranstad, Karin; Midlöv, Patrik; Halling, Anders
2017-01-01
Background Socioeconomic status and geographical factors are associated with health and use of healthcare. Well-performing primary care contributes to better health and more adequate healthcare. In a primary care system based on patient’s choice of practice, this choice (listing) is a key to understand the system. Objective To explore the relationship between population and practices in a primary care system based on listing. Methods Cross-sectional population-based study. Logistic regressions of the associations between active listing in primary care, income, education, distances to healthcare and geographical location, adjusting for multimorbidity, age, sex and type of primary care practice. Setting and subjects Population over 15 years (n=123 168) in a Swedish county, Blekinge (151 731 inhabitants), in year 2007, actively or passively listed in primary care. The proportion of actively listed was 68%. Main outcome measure Actively listed in primary care on 31 December 2007. Results Highest ORs for active listing in the model including all factors according to income had quartile two and three with OR 0.70 (95% CI 0.69 to 0.70), and those according to education less than 9 years of education had OR 0.70 (95% CI 0.68 to 0.70). Best odds for geographical factors in the same model had municipality C with OR 0.85 (95% CI 0.85 to 0.86) for active listing. Akaike’s Information Criterion (AIC) was 124 801 for a model including municipality, multimorbidity, age, sex and type of practice and including all factors gave AIC 123 934. Conclusions Higher income, shorter education, shorter distance to primary care or longer distance to hospital is associated with active listing in primary care. Multimorbidity, age, geographical location and type of primary care practice are more important to active listing in primary care than socioeconomic status and distance to healthcare. PMID:28601827
Developing a clinical information system: the role of the chief information officer.
Glaser, J
1994-11-01
Chief information officers (CIOs) must play a pivotal role in the formation and implementation of a clinical information system, the subset of an organizational information system that deals specifically with support of clinical care activities. Major elements include the applications software, technology and data architecture, databases, and analysis. The organizational structures and processes that manage the development of improvement activities, including the clinical information system itself, are just as vital to the design of an information system as the hardware and software. To develop, sustain, and advance an information infrastructure, the CIO must help establish certain organizational precursors, such as medical staff involvement, experience with quality improvement, and ability to meet data needs. The CIO must then work with the senior administrative and medical leadership in developing a vision for the information system. The CIO must also create new roles and knowledge for information system and medical staff members. Interaction between information services and medical staff is vitally important to the success of a clinical information system. Organizational committees and structures that Brigham and Women's Hospital in Boston put in place to formalize the relationship between information systems and medical staff include the Clinical Initiative Development Program and the Center for Applied Medical Information Systems Research. Improving the clinical management of care and the efficacy of care processes involves complex changes in organizational culture and processes, medical practice and information system applications, technologies, staff, and data.
NASA Technical Reports Server (NTRS)
Bodley, C. S.; Devers, A. D.; Park, A. C.; Frisch, H. P.
1978-01-01
A theoretical development and associated digital computer program system for the dynamic simulation and stability analysis of passive and actively controlled spacecraft are presented. The dynamic system (spacecraft) is modeled as an assembly of rigid and/or flexible bodies not necessarily in a topological tree configuration. The computer program system is used to investigate total system dynamic characteristics, including interaction effects between rigid and/or flexible bodies, control systems, and a wide range of environmental loadings. In addition, the program system is used for designing attitude control systems and for evaluating total dynamic system performance, including time domain response and frequency domain stability analyses.
Liu, Jie; Li, Fanfan; Shu, Kuangyi; Chen, Tao; Wang, Xiaoou; Xie, Yaoqi; Li, Shanshan; Zhang, Zhaohua; Jin, Susu; Jiang, Minghua
2018-05-13
To investigate the effect of C-reactive protein on the activated partial thromboplastin time (APTT) (different activators) in different detecting systems. The C-reactive protein and coagulation test of 112 patients with the infectious disease were determined by automation protein analyzer IMMAG 800 and automation coagulation analyzer STA-R Evolution, respectively. The pooled plasma APTT with different concentrations of C-reactive protein was measured by different detecting system: STA-R Evolution (activator: silica, kaolin), Sysmex CS-2000i (activator: ellagic acid), and ACL TOP 700 (activator: colloidal silica). In addition, the self-made platelet lysate (phospholipid) was added to correct the APTT prolonged by C-reactive protein (150 mg/L) on STA-R Evolution (activator: silica) system. The good correlation between C-reactive protein and APTT was found on the STA-R Evolution (activator: silica) system. The APTT on the STA-R Evolution (activator: silica) system was prolonged by 24.6 second, along with increasing C-reactive protein concentration. And the APTT of plasma containing 150 mg/L C-reactive protein was shortened by 3.4-6.9 second when the plasma was mixed with self-made platelet lysate. However, the APTT was prolonged unobviously on other detecting systems including STA-R Evolution (activator: kaolin), Sysmex CS-2000i, and ACL TOP 700. C-reactive protein interferes with the detection of APTT, especially in STA-R Evolution (activator: silica) system. The increasing in C-reactive protein results in a false prolongation of the APTT (activator: silica), and it is most likely that C-reactive protein interferes the coagulable factor binding of phospholipid. © 2018 Wiley Periodicals, Inc.
NASA Technical Reports Server (NTRS)
Bodley, C. S.; Devers, D. A.; Park, C. A.
1975-01-01
A theoretical development and associated digital computer program system is presented. The dynamic system (spacecraft) is modeled as an assembly of rigid and/or flexible bodies not necessarily in a topological tree configuration. The computer program system may be used to investigate total system dynamic characteristics including interaction effects between rigid and/or flexible bodies, control systems, and a wide range of environmental loadings. Additionally, the program system may be used for design of attitude control systems and for evaluation of total dynamic system performance including time domain response and frequency domain stability analyses. Volume 1 presents the theoretical developments including a description of the physical system, the equations of dynamic equilibrium, discussion of kinematics and system topology, a complete treatment of momentum wheel coupling, and a discussion of gravity gradient and environmental effects. Volume 2, is a program users' guide and includes a description of the overall digital program code, individual subroutines and a description of required program input and generated program output. Volume 3 presents the results of selected demonstration problems that illustrate all program system capabilities.
ERIC Educational Resources Information Center
Oner, Diler; Adadan, Emine
2016-01-01
This study investigated the effectiveness of an integrated web-based portfolio system, namely the BOUNCE System, which primarily focuses on improving preservice teachers' reflective thinking skills. BOUNCE©, the software component of the system, was designed and developed to support a teaching practice model including a cycle of activities to be…
The Odd Man Out: How Fathers Navigate the Special Education System
ERIC Educational Resources Information Center
Mueller, Tracy Gershwin; Buckley, Pamela C.
2014-01-01
Research about parent experiences with the special education system is largely dominated by the perspectives of mothers. Using purposeful sampling techniques, we interviewed 20 active fathers about their experiences navigating the special education system. All the fathers described three primary roles they experienced, including acting as a…
Development Activities on Airbreathing Combined Cycle Engines
NASA Technical Reports Server (NTRS)
McArthur, J. Craig; Lyles, Garry (Technical Monitor)
2000-01-01
Contents include the following: Advanced reusable transportation(ART); aerojet and rocketdyne tests, RBCC focused concept flowpaths,fabricate flight weigh, test select components, document ART project, Istar (Integrated system test of an airbreathing rocket); combined cycle propulsion testbed;hydrocarbon demonstrator tracebility; Istar engine system and vehicle system closure study; and Istar project planning.
Design of the Annular Suspension and Pointing System (ASPS) (including design addendum)
NASA Technical Reports Server (NTRS)
Cunningham, D.; Gismondi, T.; Hamilton, B.; Kendig, J.; Kiedrowski, J.; Vroman, A.; Wilson, G.
1980-01-01
The Annular Suspension and Pointing System is an experiment pointing mount designed for extremely precise 3 axis orientation of shuttle experiments. It utilizes actively controlled magnetic bearing to provide noncontacting vernier pointing and translational isolation of the experiment. The design of the system is presented and analyzed.
DOT National Transportation Integrated Search
2017-06-13
MnDOT has already deployed an extensive infrastructure for Active Traffic Management (ATM) on I-35W and I-94 with plans to expand on other segments of the Twin Cities freeway network. The ATM system includes intelligent lane control signals (ILCS) sp...
Library Labor Cost Accounting System.
ERIC Educational Resources Information Center
Du Bois, Dan
The Library Labor Cost Accounting System will provide visibility on current costs of manually processing library materials, at each campus as well as system-wide. The scope of the study includes the following: (1) 100 individual activities, grouped into 14 functional areas, e.g., Ordering, Receiving; and into 3 major operations: Acquisitions,…
Rain rate measurement capabilities using a Seasat type radar altimeter
NASA Technical Reports Server (NTRS)
Goldhirsh, J.; Walsh, E. J.
1981-01-01
The combined use of a space-based radar and a radiometer for measurement of precipitation is discussed. Phenomena to exploit or overcome is surveyed. Basic measurement problems are discussed. Several active systems are proposed, including three ocean systems and two land-sea systems. Recommendations for future research are given.
This study evaluated filtration and disinfection processes for removal and inactivation of pathogens in non-community water systems (NCWS) in two surface water supplies. Pretreatment systems included 1) pressure sand filtration, and 2) granular activated carbon adsorption, and 3...
ADHD Related Behaviors Are Associated with Brain Activation in the Reward System
ERIC Educational Resources Information Center
Stark, R.; Bauer, E.; Merz, C. J.; Zimmermann, M.; Reuter, M.; Plichta, M. M.; Kirsch, P.; Lesch, K. P.; Fallgatter, A. J.; Vaitl, D.; Herrmann, M. J.
2011-01-01
Neuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) suggest dysfunctional reward processing, with hypo-responsiveness during reward anticipation in the reward system including the nucleus accumbens (NAcc). In this study, we investigated the association between ADHD related behaviors and the reward system using functional…
Mannose-binding lectin and the balance between immune protection and complication
Takahashi, Kazue
2012-01-01
The innate immune system is evolutionarily ancient and biologically primitive. Historically, it was first identified as an element of the immune system that provides the first-line response to pathogens, and increasingly it is recognized for its central housekeeping role and its essential functions in tissue homeostasis, including coagulation and inflammation, among others. A pivotal link between the innate immune system and other functions is mannose-binding lectin (MBL), a pattern recognition molecule. Multiple studies have demonstrated that MBL deficiency increases susceptibility to infection, and the mechanisms associated with this susceptibility to infection include reduced opsonophagocytic killing and reduced activation of the lectin complement pathway. Results from our laboratory have demonstrated that MBL and MBL-associated serine protease (MASP)-1/3 together mediate coagulation factor-like activities, including thrombin-like activity. MBL and/or MASP-1/3-deficient hosts demonstrate in vivo evidence that MBL and MASP-1/3 are involved with hemostasis following injury. Staphylococcus aureus-infected MBL null mice developed disseminated intravascular coagulation, which was associated with elevated blood IL-6 levels (but not TNF-α) and systemic inflammatory responses. Infected MBL null mice also develop liver injury. These findings suggest that MBL deficiency may manifest as disseminated intravascular coagulation and organ failure with infection. Beginning from these observations, this review focuses on the interaction of innate immunity and other homeostatic systems, the derangement of which may lead to complications in infection and other inflammatory states. PMID:22114968
Baumann, Mark J.; Kuca, Michal; Aragon, Mona L.
2016-02-02
A security system includes a structure having a structural surface. The structure is sized to contain an asset therein and configured to provide a forceful breaching delay. The structure has an opening formed therein to permit predetermined access to the asset contained within the structure. The structure includes intrusion detection features within or associated with the structure that are activated in response to at least a partial breach of the structure.
Overview on NASA's Advanced Electric Propulsion Concepts Activities
NASA Technical Reports Server (NTRS)
Frisbee, Robert H.
1999-01-01
Advanced electric propulsion research activities are currently underway that seek to addresses feasibility issues of a wide range of advanced concepts, and may result in the development of technologies that will enable exciting new missions within our solar system and beyond. Each research activity is described in terms of the present focus and potential future applications. Topics include micro-electric thrusters, electrodynamic tethers, high power plasma thrusters and related applications in materials processing, variable specific impulse plasma thrusters, pulsed inductive thrusters, computational techniques for thruster modeling, and advanced electric propulsion missions and systems studies.
NASA Technical Reports Server (NTRS)
Nelson, Karl W.; McArthur, Craig; Leopard, Larry (Technical Monitor)
2000-01-01
This presentation reviews the activities of the Advanced Space Transportation Program (ASTP) in the development of Rocket-Based Combined Cycle (RBCC)technology. The document consist of the presentation slides for a talk scheduled to be given to the World Aviation Congress and Exhibit of SAE. Included in the review is discussion of recent accomplishments in the area of Advanced Reusable technologies (ART), which includes work in flowpath testing, and system studies of the various vehicle/engine combinations including RBCC, Turbine Based Combined Cycle (TBCC) and Pulsed Detonation Engine (PDE). Pictures of the proposed RBCC Flowpaths are included. The next steps in the development process are reviewed.
Nutrients in estuaries--an overview and the potential impacts of climate change.
Statham, Peter J
2012-09-15
The fate and cycling of macronutrients introduced into estuaries depend upon a range of interlinked processes. Hydrodynamics and morphology in combination with freshwater inflow control the freshwater flushing time, and the timescale for biogeochemical processes to operate that include microbial activity, particle-dissolved phase interactions, and benthic exchanges. In some systems atmospheric inputs and exchanges with coastal waters can also be important. Climate change will affect nutrient inputs and behaviour through modifications to temperature, wind patterns, the hydrological cycle, and sea level rise. Resulting impacts include: 1) inundation of freshwater systems 2) changes in stratification, flushing times and phytoplankton productivity 3) increased coastal storm activity 4) changes in species and ecosystem function. A combination of continuing high inputs of nutrients through human activity and climate change is anticipated to lead to enhanced eutrophication in the future. The most obvious impacts of increasing global temperature will be in sub-arctic systems where permafrost zones will be reduced in combination with enhanced inputs from glacial systems. Improved process understanding in several key areas including cycling of organic N and P, benthic exchanges, resuspension, impact of bio-irrigation, particle interactions, submarine groundwater discharges, and rates and magnitude of bacterially-driven recycling processes, is needed. Development of high frequency in situ nutrient analysis systems will provide data to improve predictive models that need to incorporate a wider variety of key factors, although the complexity of estuarine systems makes such modelling a challenge. However, overall a more holistic approach is needed to effectively understand, predict and manage the impact of macronutrients on estuaries. Copyright © 2011 Elsevier B.V. All rights reserved.
Advanced exterior sensor project : final report, September 2004.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ashby, M. Rodema
2004-12-01
This report (1) summarizes the overall design of the Advanced Exterior Sensor (AES) system to include detailed descriptions of system components, (2) describes the work accomplished throughout FY04 to evaluate the current health of the original prototype and to return it to operation, (3) describes the status of the AES and the AES project as of September 2004, and (4) details activities planned to complete modernization of the system to include development and testing of the second-generation AES prototype.
Solar photovoltaics for development applications
DOE Office of Scientific and Technical Information (OSTI.GOV)
Shepperd, L.W.; Richards, E.H.
1993-08-01
This document introduces photovoltaic technology to individuals and groups specializing in development activities. Examples of actual installations illustrate the many services supplied by photovoltaic systems in development applications, including water pumping, lighting, health care, refrigeration, communications, and a variety of productive uses. The various aspects of the technology are explored to help potential users evaluate whether photovoltaics can assist them in achieving their organizational goals. Basic system design, financing techniques, and the importance of infrastructure are included, along with additional sources of information and major US photovoltaic system suppliers.
Tsuboyama, Kotaro; Tadakuma, Hisashi; Tomari, Yukihide
2018-05-17
Loading of small RNAs into Argonaute, the core protein in RNA silencing, requires the Hsp70/Hsp90 chaperone machinery. This machinery also activates many other clients, including steroid hormone receptors and kinases, but how their structures change during chaperone-dependent activation remains unclear. Here, we utilized single-molecule Förster resonance energy transfer (smFRET) to probe the conformational changes of Drosophila Ago2 mediated by the chaperone machinery. We found that empty Ago2 exists in various closed conformations. The Hsp70 system (Hsp40 and Hsp70) and the Hsp90 system (Hop, Hsp90, and p23) together render Ago2 into an open, active form. The Hsp70 system, but not the Hsp90 system alone, is sufficient for Ago2 to partially populate the open form. Instead, the Hsp90 system is required to extend the dwell time of Ago2 in the open state, which must be transiently primed by the Hsp70 system. Our data uncover distinct and coordinated actions of the chaperone machinery, where the Hsp70 system expands the structural ensembles of Ago2 and the Hsp90 system captures and stabilizes the active form. Copyright © 2018 Elsevier Inc. All rights reserved.
Apollo Soyuz test project press kit: USA-USSR
NASA Technical Reports Server (NTRS)
1975-01-01
The goals and program of the mission are described. Operations from preflight crew training through splashdown are included. Spacecraft and launch vehicle configurations are given. The 27 joint and unilateral experiments to be performed are described. A flight plan and a schedule of activities is included, together with brief crew biographies. The ground support system is discussed; it includes control centers in Houston and Moscow, and an ATS satellite to relay ground-air-ground communications. The global tracking network and the television transmission system are also described.
Aeronautics and Space Report of the President: Fiscal Year 1996 Activities
NASA Technical Reports Server (NTRS)
1996-01-01
Topics considered include: (1) Space launch activities: space shuttle missions; expendable launch vehicles. (2) Space science: astronomy and space physics; solar system exploration. (3) Space flight and technology: life and microgravity sciences; space shuttle technology; reuseable launch vehicles; international space station; energy; safety and mission assurance; commercial development and regulation of space; surveillance. (4) Space communications: communications satellites; space network; ground networks; mission control and data systems. (5) Aeronautical activities: technology developments; air traffic control and navigation; weather-related aeronautical activities; flight safety and security; aviation medicine and human factors. (6) Studies of the planet earth: terrestrial studies and applications: atmospheric studies: oceanographic studies; international aeronautical and space activities; and appendices.
Non-volatile memory for checkpoint storage
DOE Office of Scientific and Technical Information (OSTI.GOV)
Blumrich, Matthias A.; Chen, Dong; Cipolla, Thomas M.
A system, method and computer program product for supporting system initiated checkpoints in high performance parallel computing systems and storing of checkpoint data to a non-volatile memory storage device. The system and method generates selective control signals to perform checkpointing of system related data in presence of messaging activity associated with a user application running at the node. The checkpointing is initiated by the system such that checkpoint data of a plurality of network nodes may be obtained even in the presence of user applications running on highly parallel computers that include ongoing user messaging activity. In one embodiment, themore » non-volatile memory is a pluggable flash memory card.« less
Higashiyama, Hiroyuki; Billin, Andrew N; Okamoto, Yuji; Kinoshita, Mine; Asano, Satoshi
2007-05-01
Peroxisome proliferator-activated receptor-delta (PPAR-delta) is known as a transcription factor involved in the regulation of fatty acid oxidation and mitochondrial biogenesis in several tissues, such as skeletal muscle, liver and adipose tissues. In this study, to elucidate systemic physiological functions of PPAR-delta, we examined the tissue distribution and localization of PPAR-delta in adult mouse tissues using tissue microarray (TMA)-based immunohistochemistry. PPAR-delta positive signals were observed on variety of tissues/cells in multiple systems including cardiovascular, urinary, respiratory, digestive, endocrine, nervous, hematopoietic, immune, musculoskeletal, sensory and reproductive organ systems. In these organs, PPAR-delta immunoreactivity was generally localized on the nucleus, although cytoplasmic localization was observed on several cell types including neurons in the nervous system and cells of the islet of Langerhans. These expression profiling data implicate various physiological roles of PPAR-delta in multiple organ systems. TMA-based immunohistochemistry enables to profile comprehensive protein localization and distribution in a high-throughput manner.
Electro optical system to measure strains at high temperature
NASA Astrophysics Data System (ADS)
Sciammarella, Cesar A.
1991-01-01
The goals of this proposal were to develop a prototype of an electro-optics system for the measurement of strains in structures at high temperatures and to perform a test under field conditions. In the research task section, the topics addressed include: (1) correction of the effect of vibrations and thermal currents by means of an active compensation system; (2) reduction of the speckle noise by means of electronic filter and TV signal reconstruction circuit; (4) compensation of the rigid body motions by mounting the camera in a universal motion system; and (5) removal of phase errors left by the active compensation system by dynamic reading. In the design and construction section, the topics addressed include: (1) preliminary design; (2) final design; (3) software development; (4) signal conditioning; (5) data processing; (6) recorrelation of two holograms in the presence of rigid body motions; and (7) phase extraction using a computer generated image. Testing in the high temperature oven is also addressed.
Pohlman, Katherine A; Carroll, Linda; Tsuyuki, Ross T; Hartling, Lisa; Vohra, Sunita
2017-12-01
Patient safety performance can be assessed with several systems, including passive and active surveillance. Passive surveillance systems provide opportunity for health care personnel to confidentially and voluntarily report incidents, including adverse events, occurring in their work environment. Active surveillance systems systematically monitor patient encounters to seek detailed information about adverse events that occur in work environments; unlike passive surveillance, active surveillance allows for collection of both numerator (number of adverse events) and denominator (number of patients seen) data. Chiropractic manual therapy is commonly used in both adults and children, yet few studies have been done to evaluate the safety of chiropractic manual therapy for children. In an attempt to evaluate this, this study will compare adverse event reporting in passive versus active surveillance systems after chiropractic manual therapy in the pediatric population. This cluster randomized controlled trial aims to enroll 70 physicians of chiropractic (unit of randomization) to either passive or active surveillance system to report adverse events that occur after treatment for 60 consecutive pediatric (13 years of age and younger) patient visits (unit of analysis). A modified enrollment process with a two-phase consent procedure will be implemented to maintain provider blinding and minimize dropouts. The first phase of consent is for the provider to confirm their interest in a trial investigating the safety of chiropractic manual therapy. The second phase ensures that they understand the specific requirements for the group to which they were randomized. Percentages, incidence estimates, and 95% confidence intervals will be used to describe the count of reported adverse events in each group. The primary outcome will be the number and quality of the adverse event reports in the active versus the passive surveillance group. With 80% power and 5% one-sided significance level, the sample size was calculated to be 35 providers in each group, which includes an 11% lost to follow-up of chiropractors and 20% of patient visits. This study will be the first direct comparison of adverse event reporting using passive versus active surveillance. It is also the largest prospective evaluation of adverse events reported after chiropractic manual therapy in children, identified as a major gap in the academic literature. ClinicalTrials.gov, ID: NCT02268331 . Registered on 10 October 2014.
NASA Technical Reports Server (NTRS)
Snell, William H.; Turner, Anne M.; Gifford, Luther; Stites, William
2010-01-01
A quality system database (QSD), and software to administer the database, were developed to support recording of administrative nonconformance activities that involve requirements for documentation of corrective and/or preventive actions, which can include ISO 9000 internal quality audits and customer complaints.
[Implementation of a computerized pharmacological database for pediatric use].
Currò, V; Grimaldi, V; Polidori, G; Cascioli, E; Lanni, R; De Luca, F; D'Atri, A; Bernabei, A
1990-01-01
The authors present a pharmacological database to support teaching and care activity carried out in the Divisional Paediatric Ambulatory of the Catholic University of Rome. This database is included in a integrated system, ARPIA (Ambulatory and Research in Pediatric by Information Assistance), devoted to manage ambulatory paediatric data. ARPIA has been implemented by using a relational DBMS, very cheap and highly diffused on personal computers. The database specifies: active ingredient and code number related to it, clinical uses, doses, contra-indications and precautions, adverse effects, besides the possible wrapping available on the market. All this is showed on a single for that appears on the screen and allows a fast reading of the most important elements characterizing every drug. The search of the included drugs can be made on the basis of three different detailed lists: active ingredient, proprietary preparation and clinical use. It is, besides, possible to have a complete report about the drugs requested by the user. This system allows the user, without modifying the program, to interact with the included data modifying each element of the form. In the system there is also a fast consultation handbook containing for every active ingredient, the complete list of italian proprietary medicines. This system aims to give a better knowledge of the most commonly used drugs, not only limited to the paediatrician but also to the ambulatory health staff; an improvement of the therapy furthering, a more effective use of several pharmacological agents and first of all a training device not only to specialists but also to students.
Seidman, Gabriel; Atun, Rifat
2017-04-13
Task shifting has become an increasingly popular way to increase access to health services, especially in low-resource settings. Research has demonstrated that task shifting, including the use of community health workers (CHWs) to deliver care, can improve population health. This systematic review investigates whether task shifting in low-income and middle-income countries (LMICs) results in efficiency improvements by achieving cost savings. Using the PRISMA guidelines for systematic reviews, we searched PubMed, Embase, CINAHL, and the Health Economic Evaluation Database on March 22, 2016. We included any original peer-review articles that demonstrated cost impact of a task shifting program in an LMIC. We identified 794 articles, of which 34 were included in our study. We found that substantial evidence exists for achieving cost savings and efficiency improvements from task shifting activities related to tuberculosis and HIV/AIDS, and additional evidence exists for the potential to achieve cost savings from activities related to malaria, NCDs, NTDs, childhood illness, and other disease areas, especially at the primary health care and community levels. Task shifting presents a viable option for health system cost savings in LMICs. Going forward, program planners should carefully consider whether task shifting can improve population health and health systems efficiency in their countries, and researchers should investigate whether task shifting can also achieve cost savings for activities related to emerging global health priorities and health systems strengthening activities such as supply chain management or monitoring and evaluation.
An Advanced Buffet Load Alleviation System
NASA Technical Reports Server (NTRS)
Burnham, Jay K.; Pitt, Dale M.; White, Edward V.; Henderson, Douglas A.; Moses, Robert W.
2001-01-01
This paper describes the development of an advanced buffet load alleviation (BLA) system that utilizes distributed piezoelectric actuators in conjunction with an active rudder to reduce the structural dynamic response of the F/A-18 aircraft vertical tails to buffet loads. The BLA system was defined analytically with a detailed finite-element-model of the tail structure and piezoelectric actuators. Oscillatory aerodynamics were included along with a buffet forcing function to complete the aeroservoelastic model of the tail with rudder control surface. Two single-input-single-output (SISO) controllers were designed, one for the active rudder and one for the active piezoelectric actuators. The results from the analytical open and closed loop simulations were used to predict the system performance. The objective of this BLA system is to extend the life of vertical tail structures and decrease their life-cycle costs. This system can be applied to other aircraft designs to address suppression of structural vibrations on military and commercial aircraft.
Magnetic bearings: Fifty years of progress
NASA Technical Reports Server (NTRS)
Swann, Michael K.
1993-01-01
Magnetic bearings are just beginning to be flown in spacecraft systems, but their development spans more than 50 years. The promise of completely noncontacting, unlubricated rotating systems operating at speeds substantially beyond the range of conventional bearings, and with no wear and virtually no vibration, has provided the incentive to develop magnetic bearing technology for many diverse applications. Earnshaw theorized in 1842 that stable magnetic suspension is not possible in all three spatial directions unless the magnetic field is actively controlled. Since that time, researchers have attempted to successfully support spinning rotors in a stable manner. Development of magnetic suspension systems over the past fifty years has included progress on both passive (permanent magnet) and active (electromagnet) systems. The improvements in bearing load capacity, stiffness, and damping characteristics are traced. The trends in rotor size, rotational kinetic energy, and improvements in active control systems capabilities are also reviewed. Implications of superconductivity on suspension system design and performance are discussed.
Underlying risk factors for prescribing errors in long-term aged care: a qualitative study.
Tariq, Amina; Georgiou, Andrew; Raban, Magdalena; Baysari, Melissa Therese; Westbrook, Johanna
2016-09-01
To identify system-related risk factors perceived to contribute to prescribing errors in Australian long-term care settings, that is, residential aged care facilities (RACFs). The study used qualitative methods to explore factors that contribute to unsafe prescribing in RACFs. Data were collected at three RACFs in metropolitan Sydney, Australia between May and November 2011. Participants included RACF managers, doctors, pharmacists and RACF staff actively involved in prescribing-related processes. Methods included non-participant observations (74 h), in-depth semistructured interviews (n=25) and artefact analysis. Detailed process activity models were developed for observed prescribing episodes supplemented by triangulated analysis using content analysis methods. System-related factors perceived to increase the risk of prescribing errors in RACFs were classified into three overarching themes: communication systems, team coordination and staff management. Factors associated with communication systems included limited point-of-care access to information, inadequate handovers, information storage across different media (paper, electronic and memory), poor legibility of charts, information double handling, multiple faxing of medication charts and reliance on manual chart reviews. Team factors included lack of established lines of responsibility, inadequate team communication and limited participation of doctors in multidisciplinary initiatives like medication advisory committee meetings. Factors related to staff management and workload included doctors' time constraints and their accessibility, lack of trained RACF staff and high RACF staff turnover. The study highlights several system-related factors including laborious methods for exchanging medication information, which often act together to contribute to prescribing errors. Multiple interventions (eg, technology systems, team communication protocols) are required to support the collaborative nature of RACF prescribing. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
30 CFR 780.10 - Information collection.
Code of Federal Regulations, 2010 CFR
2010-07-01
... COAL MINING AND RECLAMATION OPERATIONS PERMITS AND COAL EXPLORATION SYSTEMS UNDER REGULATORY PROGRAMS SURFACE MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR RECLAMATION AND OPERATION PLAN § 780.10... activities, including a requirement that the application include an operation and reclamation plan. The...
Making the Math/Science Connection.
ERIC Educational Resources Information Center
Sherman, Laurel Galbraith
1989-01-01
Suggestions are made for activities that combine the teaching of math and science. Math concepts include: graphing, estimating, measurement, statistics, geometry, and logic. Science topics include: plant reproduction, solar system, forces, longitude and latitude, Earth's magnetic field, nutrition, and heat. (IAH)
Sentinels in the Sky: Weather Satellites.
ERIC Educational Resources Information Center
Haynes, Robert
This publication describes forecasting weather activity using satellites. Information is included on the development of weather satellites, the National Oceanic and Atmospheric Administration (NOAA) Satellite System (including the polar-orbiting satellites), and the Geostationary Operational Environmental Satellite (GOES). The publication…
Sakthiswary, Rajalingham; D’Cruz, David
2014-01-01
Abstract Prepared from the plasma of thousands of blood donors, therapeutic intravenous immunoglobulin (IVIg) mostly consists of human polyspecific immunoglobulin G (IgG). The use of IVIg in systemic lupus erythematosus (SLE) is still considered experimental without any clear indications. The purpose of this systematic review is, therefore, to evaluate the available evidence to determine the therapeutic role of IVIg in SLE. A comprehensive, computerised search was performed in the MEDLINE (Pubmed), Scopus, EMBASE, and Cochrane controlled trials. The study eligibility criteria were randomized controlled trials, and prospective and retrospective observational studies that examined the efficacy of IVIg in adult patients with SLE who were considered the participants. IVIg therapy was the mode of intervention in these patients. Data abstracted included the study design, study population, changes in the disease activity scores (Systemic Lupus Erythematosus Disease Activity Index, Systemic Lupus Activity Measure, and Lupus Activity Index-Pregnancy), steroid dose, complement levels, autoantibodies, and renal function. Thereafter, data analysis established statistical procedures for meta-analysis. Thirteen studies (including 3 controlled and 10 observational) were eligible for inclusion. There was significant reduction in the SLE disease activity scores with IVIg therapy with a standard mean difference of 0.584 (P = 0.002, 95% confidence interval [CI] 0.221–0.947). In terms of rise in complement levels, the response rate was 30.9% (P = 0.001, 95 CI 22.1–41.3). The effects of IVIg on other clinical outcome measures including anti-double-stranded DNA, antinuclear antibody, average steroid dose, and renal function could not be determined because of the limited numbers of trials. The limitations of this review were lack of well-designed controlled trials with adequate sample size on the use of IVIg in SLE. In conclusion, the use of IVIg is associated with significant reduction in SLE disease activity and improvement in complement levels. PMID:25310743
Sakthiswary, Rajalingham; D'Cruz, David
2014-10-01
Prepared from the plasma of thousands of blood donors, therapeutic intravenous immunoglobulin (IVIg) mostly consists of human polyspecific immunoglobulin G (IgG). The use of IVIg in systemic lupus erythematosus (SLE) is still considered experimental without any clear indications. The purpose of this systematic review is, therefore, to evaluate the available evidence to determine the therapeutic role of IVIg in SLE. A comprehensive, computerised search was performed in the MEDLINE (Pubmed), Scopus, EMBASE, and Cochrane controlled trials. The study eligibility criteria were randomized controlled trials, and prospective and retrospective observational studies that examined the efficacy of IVIg in adult patients with SLE who were considered the participants.IVIg therapy was the mode of intervention in these patients. Data abstracted included the study design, study population, changes in the disease activity scores (Systemic Lupus Erythematosus Disease Activity Index, Systemic Lupus Activity Measure, and Lupus Activity Index-Pregnancy), steroid dose, complement levels, autoantibodies, and renal function. Thereafter, data analysis established statistical procedures for meta-analysis. Thirteen studies (including 3 controlled and 10 observational) were eligible for inclusion. There was significant reduction in the SLE disease activity scores with IVIg therapy with a standard mean difference of 0.584 (P = 0.002, 95% confidence interval [CI] 0.221-0.947). In terms of rise in complement levels, the response rate was 30.9% (P = 0.001, 95 CI 22.1-41.3). The effects of IVIg on other clinical outcome measures including anti-double-stranded DNA, antinuclear antibody, average steroid dose, and renal function could not be determined because of the limited numbers of trials. The limitations of this review were lack of well-designed controlled trials with adequate sample size on the use of IVIg in SLE. In conclusion, the use of IVIg is associated with significant reduction in SLE disease activity and improvement in complement levels.
Rehmannia glutinosa: review of botany, chemistry and pharmacology.
Zhang, Ru-Xue; Li, Mao-Xing; Jia, Zheng-Ping
2008-05-08
Rehmannia glutinosa, a widely used traditional Chinese herb, belongs to the family of Scrophulariaceae, and is taken to nourish Yin and invigorate the kidney in traditional Chinese medicine (TCM) and has a very high medicinal value. In recent decades, a great number of chemical and pharmacological studies have been done on Rehmannia glutinosa. More than 70 compounds including iridoids, saccharides, amino acid, inorganic ions, as well as other trace elements have been found in the herb. Studies show that Rehmannia glutinosa and its active principles possess wide pharmacological actions on the blood system, immune system, endocrine system, cardiovascular system and the nervous system. Currently, the effective monomeric compounds or active parts have been screened for the pharmacological activity of Rehmannia glutinosa and the highest quality scientific data is delivered to support the further application and exploitation for new drug development.
Shin, Dong-Yun; Kim, Sun Nam; Chae, Jung-Hyun; Hyun, Soon-Sil; Seo, Seung-Yong; Lee, Yong-Sil; Lee, Kwang-Ok; Kim, Seok-Ho; Lee, Yun-Sang; Jeong, Jae Min; Choi, Nam-Song; Suh, Young-Ger
2004-09-06
Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.
77 FR 67816 - Proposed Agency Information Collection Activities; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-14
... information collection on respondents, including through the use of automated collection techniques or other... trades driven by retail investors versus those that are wholesale driven. This would yield information... FEDERAL RESERVE SYSTEM Proposed Agency Information Collection Activities; Comment Request AGENCY...
ERIC Educational Resources Information Center
Wolter, Kurt A.; Foster, Patrick N.
1995-01-01
Describes a learning activity that involves planning a community and then altering the transportation system to meet new specifications. Includes the rationale for the activity, how it fits into the technology education curriculum, and how it was implemented to fit a variety of age and grade levels. (JOW)
78 FR 66714 - Proposed Agency Information Collection Activities; Comment Request
Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-06
..., including through the use of automated collection techniques or other forms of information technology; and e... three data items: Government-guaranteed Student Loans, Private Student Loans, and Other Consumer Loans... FEDERAL RESERVE SYSTEM Proposed Agency Information Collection Activities; Comment Request AGENCY...
Advanced aerodynamics and active controls. Selected NASA research
NASA Technical Reports Server (NTRS)
1981-01-01
Aerodynamic and active control concepts for application to commercial transport aircraft are discussed. Selected topics include in flight direct strike lightning research, triply redundant digital fly by wire control systems, tail configurations, winglets, and the drones for aerodynamic and structural testing (DAST) program.
NASA Technical Reports Server (NTRS)
Wilbur, Matthew L.; Yeager, William T., Jr.; Sekula, Martin K.
2002-01-01
The vibration reduction capabilities of a model rotor system utilizing controlled, strain-induced blade twisting are examined. The model rotor blades, which utilize piezoelectric active fiber composite actuators, were tested in the NASA Langley Transonic Dynamics Tunnel using open-loop control to determine the effect of active-twist on rotor vibratory loads. The results of this testing have been encouraging, and have demonstrated that active-twist rotor designs offer the potential for significant load reductions in future helicopter rotor systems. Active twist control was found to use less than 1% of the power necessary to operate the rotor system and had a pronounced effect on both rotating- and fixed-system loads, offering reductions in individual harmonic loads of up to 100%. A review of the vibration reduction results obtained is presented, which includes a limited set of comparisons with results generated using the second-generation version of the Comprehensive Analytical Model of Rotorcraft Aerodynamics and Dynamics (CAMRAD II) rotorcraft comprehensive analysis.
NASA Technical Reports Server (NTRS)
Leboeuf, Claudia M.; Davila, Pamela S.; Redding, David C.; Morell, Armando; Lowman, Andrew E.; Wilson, Mark E.; Young, Eric W.; Pacini, Linda K.; Coulter, Dan R.
1998-01-01
As part of the technology validation strategy of the next generation space telescope (NGST), a system testbed is being developed at GSFC, in partnership with JPL and Marshall Space Flight Center (MSFC), which will include all of the component functions envisioned in an NGST active optical system. The system will include an actively controlled, segmented primary mirror, actively controlled secondary, deformable, and fast steering mirrors, wavefront sensing optics, wavefront control algorithms, a telescope simulator module, and an interferometric wavefront sensor for use in comparing final obtained wavefronts from different tests. The developmental. cryogenic active telescope testbed (DCATT) will be implemented in three phases. Phase 1 will focus on operating the testbed at ambient temperature. During Phase 2, a cryocapable segmented telescope will be developed and cooled to cryogenic temperature to investigate the impact on the ability to correct the wavefront and stabilize the image. In Phase 3, it is planned to incorporate industry developed flight-like components, such as figure controlled mirror segments, cryogenic, low hold power actuators, or different wavefront sensing and control hardware or software. A very important element of the program is the development and subsequent validation of the integrated multidisciplinary models. The Phase 1 testbed objectives, plans, configuration, and design will be discussed.
Kurosaki, Mitsuhaya; Shirao, Naoko; Yamashita, Hidehisa; Okamoto, Yasumasa; Yamawaki, Shigeto
2006-02-15
Our aim was to study the gender differences in brain activation upon viewing visual stimuli of distorted images of one's own body. We performed functional magnetic resonance imaging on 11 healthy young men and 11 healthy young women using the "body image tasks" which consisted of fat, real, and thin shapes of the subject's own body. Comparison of the brain activation upon performing the fat-image task versus real-image task showed significant activation of the bilateral prefrontal cortex and left parahippocampal area including the amygdala in the women, and significant activation of the right occipital lobe including the primary and secondary visual cortices in the men. Comparison of brain activation upon performing the thin-image task versus real-image task showed significant activation of the left prefrontal cortex, left limbic area including the cingulate gyrus and paralimbic area including the insula in women, and significant activation of the occipital lobe including the left primary and secondary visual cortices in men. These results suggest that women tend to perceive distorted images of their own bodies by complex cognitive processing of emotion, whereas men tend to perceive distorted images of their own bodies by object visual processing and spatial visual processing.