The space shuttle launch vehicle aerodynamic verification challenges

NASA Technical Reports Server (NTRS)

Wallace, R. O.; Austin, L. D.; Hondros, J. G.; Surber, T. E.; Gaines, L. M.; Hamilton, J. T.

1985-01-01

The Space Shuttle aerodynamics and performance communities were challenged to verify the Space Shuttle vehicle (SSV) aerodynamics and system performance by flight measurements. Historically, launch vehicle flight test programs which faced these same challenges were unmanned instrumented flights of simple aerodynamically shaped vehicles. However, the manned SSV flight test program made these challenges more complex because of the unique aerodynamic configuration powered by the first man-rated solid rocket boosters (SRB). The analyses of flight data did not verify the aerodynamics or performance preflight predictions of the first flight of the Space Transportation System (STS-1). However, these analyses have defined the SSV aerodynamics and verified system performance. The aerodynamics community also was challenged to understand the discrepancy between the wind tunnel and flight defined aerodynamics. The preflight analysis challenges, the aerodynamic extraction challenges, and the postflight analyses challenges which led to the SSV system performance verification and which will lead to the verification of the operational ascent aerodynamics data base are presented.

Earth Observing System (EOS) Aqua and Aura Space Weather Effects on Operational Collision Avoidance

NASA Technical Reports Server (NTRS)

Guit, Bill

2017-01-01

This presentation will describe recent EOS Aqua and Aura operational collision avoidance experience during periods of solar and geomagnetic storm activity. It will highlight challenges faced by the operations team during short-notice, high-risk predicted close approaches. The presentation will highlight the evolution of the operational collision avoidance process for the EOS Aqua and Aura missions. The presentation will highlight operational challenges that have occurred, process improvements that have been implemented and identify potential future challenges.

A Major Force in Economic Development: A Challenge for the North Carolina Community College System.

ERIC Educational Resources Information Center

Lancaster, H. Martin

No other institution has played a more significant role in support of economic development in North Carolina than the North Carolina Community College System. Presented are three challenges that will define the System's future relevance in support of economic development: (1) its ability to stay ahead of the "tidal wave" that is…

Evaluation of average daily gain predictions by the integrated farm system model for forage-finished beef steers

USDA-ARS?s Scientific Manuscript database

Representing the performance of cattle finished on an all forage diet in process-based whole farm system models has presented a challenge. To address this challenge, a study was done to evaluate average daily gain (ADG) predictions of the Integrated Farm System Model (IFSM) for steers consuming all-...

Wireless Instrumentation Systems for Flight Testing at NASA AFRC

NASA Technical Reports Server (NTRS)

Hang, Richard

2017-01-01

NASA Armstrong Flight Research Center is revolutionizing its traditional wired instrumentation systems with wireless technologies. This effort faces many technical challenges, such as spectrum compliance, time synchronization, power distribution and airworthiness. This presentation summarizes NASA AFRC's flight test capabilities with current conventional instrumentation methodology and highlights the technical challenges of wireless systems used for flight test research applications.

Quantitative computational models of molecular self-assembly in systems biology

PubMed Central

Thomas, Marcus; Schwartz, Russell

2017-01-01

Molecular self-assembly is the dominant form of chemical reaction in living systems, yet efforts at systems biology modeling are only beginning to appreciate the need for and challenges to accurate quantitative modeling of self-assembly. Self-assembly reactions are essential to nearly every important process in cell and molecular biology and handling them is thus a necessary step in building comprehensive models of complex cellular systems. They present exceptional challenges, however, to standard methods for simulating complex systems. While the general systems biology world is just beginning to deal with these challenges, there is an extensive literature dealing with them for more specialized self-assembly modeling. This review will examine the challenges of self-assembly modeling, nascent efforts to deal with these challenges in the systems modeling community, and some of the solutions offered in prior work on self-assembly specifically. The review concludes with some consideration of the likely role of self-assembly in the future of complex biological system models more generally. PMID:28535149

Quantitative computational models of molecular self-assembly in systems biology.

PubMed

Thomas, Marcus; Schwartz, Russell

2017-05-23

Molecular self-assembly is the dominant form of chemical reaction in living systems, yet efforts at systems biology modeling are only beginning to appreciate the need for and challenges to accurate quantitative modeling of self-assembly. Self-assembly reactions are essential to nearly every important process in cell and molecular biology and handling them is thus a necessary step in building comprehensive models of complex cellular systems. They present exceptional challenges, however, to standard methods for simulating complex systems. While the general systems biology world is just beginning to deal with these challenges, there is an extensive literature dealing with them for more specialized self-assembly modeling. This review will examine the challenges of self-assembly modeling, nascent efforts to deal with these challenges in the systems modeling community, and some of the solutions offered in prior work on self-assembly specifically. The review concludes with some consideration of the likely role of self-assembly in the future of complex biological system models more generally.

In vitro Alternative Methodologies for Central Nervous System Assessment: A Critique using Nanoscale Materials as an Example.

EPA Science Inventory

Identifying the potential health hazards to the central nervous system of a new family of materials presents many challenges. Whole-animal toxicity testing has been the tradition, but in vitro methods have been steadily gaining popularity. There are numerous challenges in testing...

Big Data in the Earth Observing System Data and Information System

NASA Technical Reports Server (NTRS)

Lynnes, Chris; Baynes, Katie; McInerney, Mark

2016-01-01

Approaches that are being pursued for the Earth Observing System Data and Information System (EOSDIS) data system to address the challenges of Big Data were presented to the NASA Big Data Task Force. Cloud prototypes are underway to tackle the volume challenge of Big Data. However, advances in computer hardware or cloud won't help (much) with variety. Rather, interoperability standards, conventions, and community engagement are the key to addressing variety.

Next generation system modeling of NTR systems

NASA Technical Reports Server (NTRS)

Buksa, John J.; Rider, William J.

1993-01-01

The topics are presented in viewgraph form and include the following: nuclear thermal rocket (NTR) modeling challenges; current approaches; shortcomings of current analysis method; future needs; and present steps to these goals.

bb̅ud̅ four-quark systems in the Born-Oppenheimer approximation: prospects and challenges

NASA Astrophysics Data System (ADS)

Peters, Antje; Bicudo, Pedro; Wagner, Marc

2018-03-01

We summarize previous work on b̅b̅ud four-quark systems in the Born-Oppenheimer approximation and discuss first steps towards an extension to the theoretically more challenging bb̅ud̅ system. Strategies to identify a possibly existing bb̅ud̅ bound state are discussed and first numerical results are presented.

Using the Electronic Health Record in Nursing Research: Challenges and Opportunities.

PubMed

Samuels, Joanne G; McGrath, Robert J; Fetzer, Susan J; Mittal, Prashant; Bourgoine, Derek

2015-10-01

Changes in the patient record from the paper to the electronic health record format present challenges and opportunities for the nurse researcher. Current use of data from the electronic health record is in a state of flux. Novel data analytic techniques and massive data sets provide new opportunities for nursing science. Realization of a strong electronic data output future relies on meeting challenges of system use and operability, data presentation, and privacy. Nurse researchers need to rethink aspects of proposal development. Joining ongoing national efforts aimed at creating usable data output is encouraged as a means to affect system design. Working to address challenges and embrace opportunities will help grow the science in a way that answers important patient care questions. © The Author(s) 2015.

What Are the Professional, Political, and Ethical Challenges of Co-Creating Health Care Systems?

PubMed

Singh, Guddi; Owens, John; Cribb, Alan

2017-11-01

Co-creation is seen by many as a means of meeting the multiple challenges facing contemporary health care systems by involving institutions, professionals, patients, and stakeholders in new roles, relationships, and collaborative practices. While co-creation has the potential to positively transform health care systems, it generates a number of political and ethical challenges that should not be overlooked. We suggest that those involved in envisioning and implementing co-creation initiatives pay close attention to significant questions of equity, power, and justice and to the fundamental challenge of securing a common vision of the aims of and agendas for health care systems. While such initiatives present significant opportunities for improvement, they need to be viewed in light of their accompanying professional, political, and ethical challenges. © 2017 American Medical Association. All Rights Reserved.

Melanoma central nervous system metastases: current approaches, challenges, and opportunities

PubMed Central

Cohen, Justine V.; Tawbi, Hussain; Margolin, Kim A.; Amravadi, Ravi; Bosenberg, Marcus; Brastianos, Priscilla K.; Chiang, Veronica L.; de Groot, John; Glitza, Isabella C.; Herlyn, Meenhard; Holmen, Sheri L.; Jilaveanu, Lucia B.; Lassman, Andrew; Moschos, Stergios; Postow, Michael A.; Thomas, Reena; Tsiouris, John A.; Wen, Patrick; White, Richard M.; Turnham, Timothy; Davies, Michael A.; Kluger, Harriet M.

2017-01-01

Summary Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area. PMID:27615400

Security, development and human rights: normative, legal and policy challenges for the international drug control system.

PubMed

Barrett, Damon

2010-03-01

This commentary addresses some of the challenges posed by the broader normative, legal and policy framework of the United Nations for the international drug control system. The 'purposes and principles' of the United Nations are presented and set against the threat based rhetoric of the drug control system and the negative consequences of that system. Some of the challenges posed by human rights law and norms to the international drug control system are also described, and the need for an impact assessment of the current system alongside alternative policy options is highlighted as a necessary consequence of these analyses. Copyright (c) 2010 Elsevier B.V. All rights reserved.

The Apollo Expericence Lessons Learned for Constellation Lunar Dust Management

NASA Astrophysics Data System (ADS)

Wagner, Sandra

2006-09-01

Lunar dust will present significant challenges to NASA's Lunar Exploration Missions. The challenges can be overcome by using best practices in system engineering design. For successful lunar surface missions, all systems that come into contact with lunar dust must consider the effects throughout the entire design process. Interfaces between all these systems with other systems also must be considered. Incorporating dust management into Concept of Operations and Requirements development are the best place to begin to mitigate the risks presented by lunar dust. However, that is only the beginning. To be successful, every person who works on NASA's Constellation lunar missions must be mindful of this problem. Success will also require fiscal responsibility. NASA must learn from Apollo the root cause of problems caused by dust, and then find the most cost-effective solutions to address each challenge. This will require a combination of common sense existing technologies and promising, innovative technical solutions

The Apollo Experience Lessons Learned for Constellation Lunar Dust Management

NASA Technical Reports Server (NTRS)

Wagner, Sandra

2006-01-01

Lunar dust will present significant challenges to NASA's Lunar Exploration Missions. The challenges can be overcome by using best practices in system engineering design. For successful lunar surface missions, all systems that come into contact with lunar dust must consider the effects throughout the entire design process. Interfaces between all these systems with other systems also must be considered. Incorporating dust management into Concept of Operations and Requirements development are the best place to begin to mitigate the risks presented by lunar dust. However, that is only the beginning. To be successful, every person who works on NASA's Constellation lunar missions must be mindful of this problem. Success will also require fiscal responsibility. NASA must learn from Apollo the root cause of problems caused by dust, and then find the most cost-effective solutions to address each challenge. This will require a combination of common sense existing technologies and promising, innovative technical solutions

Laboratory Information Systems in Molecular Diagnostics: Why Molecular Diagnostics Data are Different.

PubMed

Lee, Roy E; Henricks, Walter H; Sirintrapun, Sahussapont J

2016-03-01

Molecular diagnostic testing presents new challenges to information management that are yet to be sufficiently addressed by currently available information systems for the molecular laboratory. These challenges relate to unique aspects of molecular genetic testing: molecular test ordering, informed consent issues, diverse specimen types that encompass the full breadth of specimens handled by traditional anatomic and clinical pathology information systems, data structures and data elements specific to molecular testing, varied testing workflows and protocols, diverse instrument outputs, unique needs and requirements of molecular test reporting, and nuances related to the dissemination of molecular pathology test reports. By satisfactorily addressing these needs in molecular test data management, a laboratory information system designed for the unique needs of molecular diagnostics presents a compelling reason to migrate away from the current paper and spreadsheet information management that many molecular laboratories currently use. This paper reviews the issues and challenges of information management in the molecular diagnostics laboratory.

NASA's Use of Commercial Satellite Systems: Concepts and Challenges

NASA Technical Reports Server (NTRS)

Budinger, James M.

1998-01-01

Lewis Research Center's Space Communications Program has a responsibility to investigate, plan for, and demonstrate how NASA Enterprises can use advanced commercial communications services and technologies to satisfy their missions' space communications needs. This presentation looks at the features and challenges of alternative hardware system architecture concepts for providing specific categories of communications services.

Livestock waste treatment systems of the future: A challenge to environmental quality, food safety, and sustainability. OECD Workshop

USDA-ARS?s Scientific Manuscript database

This Special Issue of Bioresource Technology is dedicated to selected contributions presented at the international Workshop: “Livestock waste treatment systems of the future: A challenge to environmental quality, food safety, and sustainability,” held 2-4 April, 2008, in Florence, South Carolina (US...

Challenges in Integrating a Complex Systems Computer Simulation in Class: An Educational Design Research

ERIC Educational Resources Information Center

Loke, Swee-Kin; Al-Sallami, Hesham S.; Wright, Daniel F. B.; McDonald, Jenny; Jadhav, Sheetal; Duffull, Stephen B.

2012-01-01

Complex systems are typically difficult for students to understand and computer simulations offer a promising way forward. However, integrating such simulations into conventional classes presents numerous challenges. Framed within an educational design research, we studied the use of an in-house built simulation of the coagulation network in four…

Higher Education as an Instrument of Economic Growth in Kenya

ERIC Educational Resources Information Center

Nyangau, Josiah Z.

2014-01-01

The purpose of the present paper is to identify the main challenges facing Kenya's public higher education system and to propose plausible and, concrete steps policy makers and educational leaders can take to address those challenges to ensure the country's higher education system prepares the human capital, which is necessary for the construction…

Information and Communications Technology (ICT) in Nigeria Educational Assessment System--Emerging Challenges

ERIC Educational Resources Information Center

Aworanti, Olatunde Awotokun

2016-01-01

This paper examines Information and Communications Technology (ICT) in Nigeria educational assessment system with its emerging challenges. This is inevitable following the globalisation trend which has brought drastic changes in the world of technology. The essence of the paper is to describe the present status of ICT in the Nigeria educational…

Challenges posed to the European pharmaceutical regulatory system by highly personalized medicines.

PubMed

Johnston, John D; Feldschreiber, Peter

2014-03-01

The European pharmaceutical regulatory system has not yet been challenged by issues related to highly personalized medicines such as those to be found with active substances that affect RNA biochemistry. We review the current status of RNA-based pharmacology and present three possible case histories. The implications for the European pharmaceutical regulatory system are discussed. © 2013 The British Pharmacological Society.

The University in the Networked Economy and Society: Challenges and Opportunities

ERIC Educational Resources Information Center

Benkler, Yochai

2008-01-01

The networked information economy and society present a new social, technical, and economic environment within which the university functions. To understand the new challenges and opportunities this environment presents, a usable characterization of the core new characteristics of both the environment and the university as a system and how those…

Computer-Assisted Diagnostic Decision Support: History, Challenges, and Possible Paths Forward

ERIC Educational Resources Information Center

Miller, Randolph A.

2009-01-01

This paper presents a brief history of computer-assisted diagnosis, including challenges and future directions. Some ideas presented in this article on computer-assisted diagnostic decision support systems (CDDSS) derive from prior work by the author and his colleagues (see list in Acknowledgments) on the INTERNIST-1 and QMR projects. References…

Information Systems for Government and Business: Challenges and Opportunities. Report and Summary of Proceedings of the Kawasaki International Seminar on the Information Systems Challenge for Government and Business (2nd, Kawasaki City, Japan, July 21-24, 1987). UNCRD Meeting Report Series, No. 23.

ERIC Educational Resources Information Center

United Nations Centre for Regional Development, Nagoya (Japan).

This report summarizes the presentations and discussions at an international seminar designed to provide an opportunity for the exchange of ideas about maximizing the use of information technology as a strategic weapon for achieving organizational changes and goals, and for achieving a competitive advantage. Among these presentations were the…

Online Learning: Addressing Challenges and Seizing Opportunities. Oregon

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

Online Learning: Addressing Challenges and Seizing Opportunities. Minnesota

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

30 CFR 773.27 - Burden of proof for ownership or control challenges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... regulatory authority. The materials presented in connection with your challenge will become part of the... challenges. 773.27 Section 773.27 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT... SYSTEMS UNDER REGULATORY PROGRAMS REQUIREMENTS FOR PERMITS AND PERMIT PROCESSING § 773.27 Burden of proof...

Online Learning: Addressing Challenges and Seizing Opportunities. Idaho

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

Online Learning: Addressing Challenges and Seizing Opportunities. New Mexico

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

Farms and Learning Partnerships in Farming Systems Projects: A Response to the Challenges of Complexity in Agricultural Innovation

ERIC Educational Resources Information Center

Crawford, Anne; Nettle, Ruth; Paine, Mark; Kabore, Carolyn

2007-01-01

Managing the competing interests of productivity growth, environmental concerns, landscape change and societal expectations presents challenges for agricultural industries. Innovation projects supporting knowledge development to address these challenges often involve partnerships with commercial farms, a methodology which promises much but has…

Online Learning: Addressing Challenges and Seizing Opportunities. New Hampshire

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

Online Learning: Addressing Challenges and Seizing Opportunities. Hawaii

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

Online Learning: Addressing Challenges and Seizing Opportunities. Wisconsin

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…

NASA Space Rocket Logistics Challenges

NASA Technical Reports Server (NTRS)

Bramon, Chris; Neeley, James R.; Jones, James V.; Watson, Michael D.; Inman, Sharon K.; Tuttle, Loraine

2014-01-01

The Space Launch System (SLS) is the new NASA heavy lift launch vehicle in development and is scheduled for its first mission in 2017. SLS has many of the same logistics challenges as any other large scale program. However, SLS also faces unique challenges. This presentation will address the SLS challenges, along with the analysis and decisions to mitigate the threats posed by each.

OOSTT: a Resource for Analyzing the Organizational Structures of Trauma Centers and Trauma Systems

PubMed Central

Utecht, Joseph; Judkins, John; Otte, J. Neil; Colvin, Terra; Rogers, Nicholas; Rose, Robert; Alvi, Maria; Hicks, Amanda; Ball, Jane; Bowman, Stephen M.; Maxson, Robert T.; Nabaweesi, Rosemary; Pradhan, Rohit; Sanddal, Nels D.; Tudoreanu, M. Eduard; Winchell, Robert J.; Brochhausen, Mathias

2017-01-01

Organizational structures of healthcare organizations has increasingly become a focus of medical research. In the CAFÉ project we aim to provide a web-service enabling ontology-driven comparison of the organizational characteristics of trauma centers and trauma systems. Trauma remains one of the biggest challenges to healthcare systems worldwide. Research has demonstrated that coordinated efforts like trauma systems and trauma centers are key components of addressing this challenge. Evaluation and comparison of these organizations is essential. However, this research challenge is frequently compounded by the lack of a shared terminology and the lack of effective information technology solutions for assessing and comparing these organizations. In this paper we present the Ontology of Organizational Structures of Trauma systems and Trauma centers (OOSTT) that provides the ontological foundation to CAFÉ's web-based questionnaire infrastructure. We present the usage of the ontology in relation to the questionnaire and provide the methods that were used to create the ontology. PMID:28217041

The challenge of benchmarking health systems: is ICT innovation capacity more systemic than organizational dependent?

PubMed

Lapão, Luís Velez

2015-01-01

The article by Catan et al. presents a benchmarking exercise comparing Israel and Portugal on the implementation of Information and Communication Technologies in the healthcare sector. Special attention was given to e-Health and m-Health. The authors collected information via a set of interviews with key stakeholders. They compared two different cultures and societies, which have reached slightly different implementation outcomes. Although the comparison is very enlightening, it is also challenging. Benchmarking exercises present a set of challenges, such as the choice of methodologies and the assessment of the impact on organizational strategy. Precise benchmarking methodology is a valid tool for eliciting information about alternatives for improving health systems. However, many beneficial interventions, which benchmark as effective, fail to translate into meaningful healthcare outcomes across contexts. There is a relationship between results and the innovational and competitive environments. Differences in healthcare governance and financing models are well known; but little is known about their impact on Information and Communication Technology implementation. The article by Catan et al. provides interesting clues about this issue. Public systems (such as those of Portugal, UK, Sweden, Spain, etc.) present specific advantages and disadvantages concerning Information and Communication Technology development and implementation. Meanwhile, private systems based fundamentally on insurance packages, (such as Israel, Germany, Netherlands or USA) present a different set of advantages and disadvantages - especially a more open context for innovation. Challenging issues from both the Portuguese and Israeli cases will be addressed. Clearly, more research is needed on both benchmarking methodologies and on ICT implementation strategies.

A Review on Potential Issues and Challenges in MR Imaging

PubMed Central

Kanakaraj, Jagannathan

2013-01-01

Magnetic resonance imaging is a noninvasive technique that has been developed for its excellent depiction of soft tissue contrasts. Instruments capable of ultra-high field strengths, ≥7 Tesla, were recently engineered and have resulted in higher signal-to-noise and higher resolution images. This paper presents various subsystems of the MR imaging systems like the magnet subsystem, gradient subsystem, and also various issues which arise due to the magnet. Further, it also portrays finer details about the RF coils and transceiver and also various limitations of the RF coils and transceiver. Moreover, the concept behind the data processing system and the challenges related to it were also depicted. Finally, the various artifacts associated with the MR imaging were clearly pointed out. It also presents a brief overview about all the challenges related to MR imaging systems. PMID:24381523

Smart factory in the context of 4th industrial revolution: challenges and opportunities for Romania

NASA Astrophysics Data System (ADS)

Pîrvu, B. C.; Zamfirescu, C. B.

2017-08-01

Manufacturing companies, independent of operation sector and size, must be able to produce lot size one products, just-in-time at a competitive cost. Coping with this high adaptability and short reaction times proves to be very challenging. New approaches must be taken into consideration for designing modular, intelligent and cooperative production systems which are easy to integrate with the entire factory. The coined term for this network of intelligent interacting artefacts system is cyber-physical systems (CPS). CPS is often used in the context of Industry 4.0 - or what many consider the forth industrial revolution. The paper presents an overview of key technological and social requirements to map the Smart Factory vision into reality. Finally, global and Romanian specific challenges hindering the vision of a true Smart Factory to become reality are presented.

Material Challenges and Opportunities for Commercial Electric Aircraft

NASA Technical Reports Server (NTRS)

Misra, Ajay

2014-01-01

Significant reduction in carbon dioxide emission for future air transportation system will require adoption of electric propulsion system and more electric architectures. Various options for aircraft electric propulsion include hybrid electric, turboelectric, and full electric system. Realization of electric propulsion system for commercial aircraft applications will require significant increases in power density of electric motors and energy density of energy storage system, such as the batteries and fuel cells. In addition, transmission of MW of power in the aircraft will require high voltage power transmission system to reduce the weight of the power transmission system. Finally, there will be significant thermal management challenges. Significant advances in material technologies will be required to meet these challenges. Technologies of interest include materials with higher electrical conductivity than Cu, high thermal conductivity materials, and lightweight electrically insulating materials with high breakdown voltage, high temperature magnets, advanced battery and fuel cell materials, and multifunctional materials. The presentation will include various challenges for commercial electric aircraft and provide an overview of material improvements that will be required to meet these challenges.

Microfluidics-Enabled Diagnostic Systems: Markets, Challenges, and Examples.

PubMed

Becker, Holger; Gärtner, Claudia

2017-01-01

Microfluidics has become an important tool for the commercial product development in diagnostics. This article will focus on current technical demands during the development process such as material and integration challenges. Furthermore, we present data on the diagnostics market as well as examples of microfluidics-enabled systems currently under commercial development or already on the market.

South Dakota Statewide Core Curriculum, Career Ladder and Challenge System: Volumes I and II. Final Report.

ERIC Educational Resources Information Center

1975

The two volume final report of the South Dakota Statewide Core Curriculum, Career Ladder, and Challenge System Project, coordinating associated health and nursing education on a statewide basis to achieve a more systematic production and utilization of health manpower, is presented. Volume 1 includes five chapters: (1) and (2) outlining funding…

Building a Solar System Internet

NASA Technical Reports Server (NTRS)

Clark, Gilbert J.

2018-01-01

This presentation is expected to be given during the scheduled Communications Technology and Development discussion in the University Student Design Challenge (2). It is an introduction to various challenges inherent to the construction of networks in space. The presentation also includes both an overview of networking in general, as well as approaches taken to the construction of delay- and disruption- tolerant networks.

Comparison of calibration and standardization approaches for fluorescence guided imaging systems to benchtop fluorescence measurements in cellular systems

NASA Astrophysics Data System (ADS)

Litorja, Maritoni; DeRose, Paul

2018-02-01

Fluorescence measurements are a staple in biomedicine, from research and discovery to more recently, for fluorescenceguided imaging systems for diagnostics and surgery. Measurement validation for clinical imagers is a challenge as it is applied to many different optical systems and probe through matrices with different optical properties in a demanding field environment. In this paper we will present approaches to fluorescence calibration for a field system, in comparison to those used in laboratory instruments for cell measurements or benchtop fluorometers. We will present the common challenges and differences, and lessons from the standardization effort of laboratory fluorescence measurements. We will discuss the conceptually different pathways to measurement traceability, between counting moles of substance and measuring light.

Generating a Reduced Gravity Environment on Earth

NASA Technical Reports Server (NTRS)

Dungan, Larry K.; Cunningham, Tom; Poncia, Dina

2010-01-01

Since the 1950s several reduced gravity simulators have been designed and utilized in preparing humans for spaceflight and in reduced gravity system development. The Active Response Gravity Offload System (ARGOS) is the newest and most realistic gravity offload simulator. ARGOS provides three degrees of motion within the test area and is scalable for full building deployment. The inertia of the overhead system is eliminated by an active motor and control system. This presentation will discuss what ARGOS is, how it functions, and the unique challenges of interfacing to the human. Test data and video for human and robotic systems will be presented. A major variable in the human machine interaction is the interface of ARGOS to the human. These challenges along with design solutions will be discussed.

NASA Space Flight Vehicle Fault Isolation Challenges

NASA Technical Reports Server (NTRS)

Neeley, James R.; Jones, James V.; Bramon, Christopher J.; Inman, Sharon K.; Tuttle, Loraine

2016-01-01

The Space Launch System (SLS) is the new NASA heavy lift launch vehicle in development and is scheduled for its first mission in 2018.SLS has many of the same logistics challenges as any other large scale program. However, SLS also faces unique challenges related to testability. This presentation will address the SLS challenges for diagnostics and fault isolation, along with the analyses and decisions to mitigate risk..

High-End Computing Challenges in Aerospace Design and Engineering

NASA Technical Reports Server (NTRS)

Bailey, F. Ronald

2004-01-01

High-End Computing (HEC) has had significant impact on aerospace design and engineering and is poised to make even more in the future. In this paper we describe four aerospace design and engineering challenges: Digital Flight, Launch Simulation, Rocket Fuel System and Digital Astronaut. The paper discusses modeling capabilities needed for each challenge and presents projections of future near and far-term HEC computing requirements. NASA's HEC Project Columbia is described and programming strategies presented that are necessary to achieve high real performance.

Real-time scheduling faces operational challenges.

PubMed

2005-01-01

Online real-time patient scheduling presents a number of challenges. But a few advanced organizations are rolling out systems slowly, meeting those challenges as they go. And while this application is still too new to provide measurable benefits, anecdotal information seems to point to improvements in efficiency, patient satisfaction, and possibly quality of care.

The Interaction of Spacecraft Cabin Atmospheric Quality and Water Processing System Performance

NASA Technical Reports Server (NTRS)

Perry, Jay L.; Croomes, Scott D. (Technical Monitor)

2002-01-01

Although designed to remove organic contaminants from a variety of waste water streams, the planned U.S.- and present Russian-provided water processing systems onboard the International Space Station (ISS) have capacity limits for some of the more common volatile cleaning solvents used for housekeeping purposes. Using large quantities of volatile cleaning solvents during the ground processing and in-flight operational phases of a crewed spacecraft such as the ISS can lead to significant challenges to the water processing systems. To understand the challenges facing the management of water processing capacity, the relationship between cabin atmospheric quality and humidity condensate loading is presented. This relationship is developed as a tool to determine the cabin atmospheric loading that may compromise water processing system performance. A comparison of cabin atmospheric loading with volatile cleaning solvents from ISS, Mir, and Shuttle are presented to predict acceptable limits to maintain optimal water processing system performance.

Technology Challenges and Opportunities for Very Large In-Space Structural Systems

NASA Technical Reports Server (NTRS)

Belvin, W. Keith; Dorsey, John T.; Watson, Judith J.

2009-01-01

Space solar power satellites and other large space systems will require creative and innovative concepts in order to achieve economically viable designs. The mass and volume constraints of current and planned launch vehicles necessitate highly efficient structural systems be developed. In addition, modularity and in-space deployment/construction will be enabling design attributes. While current space systems allocate nearly 20 percent of the mass to the primary structure, the very large space systems of the future must overcome subsystem mass allocations by achieving a level of functional integration not yet realized. A proposed building block approach with two phases is presented to achieve near-term solar power satellite risk reduction with accompanying long-term technology advances. This paper reviews the current challenges of launching and building very large space systems from a structures and materials perspective utilizing recent experience. Promising technology advances anticipated in the coming decades in modularity, material systems, structural concepts, and in-space operations are presented. It is shown that, together, the current challenges and future advances in very large in-space structural systems may provide the technology pull/push necessary to make solar power satellite systems more technically and economically feasible.

Challenges & Roadmap for Beyond CMOS Computing Simulation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodrigues, Arun F.; Frank, Michael P.

Simulating HPC systems is a difficult task and the emergence of “Beyond CMOS” architectures and execution models will increase that difficulty. This document presents a “tutorial” on some of the simulation challenges faced by conventional and non-conventional architectures (Section 1) and goals and requirements for simulating Beyond CMOS systems (Section 2). These provide background for proposed short- and long-term roadmaps for simulation efforts at Sandia (Sections 3 and 4). Additionally, a brief explanation of a proof-of-concept integration of a Beyond CMOS architectural simulator is presented (Section 2.3).

Reliability, Safety and Error Recovery for Advanced Control Software

NASA Technical Reports Server (NTRS)

Malin, Jane T.

2003-01-01

For long-duration automated operation of regenerative life support systems in space environments, there is a need for advanced integration and control systems that are significantly more reliable and safe, and that support error recovery and minimization of operational failures. This presentation outlines some challenges of hazardous space environments and complex system interactions that can lead to system accidents. It discusses approaches to hazard analysis and error recovery for control software and challenges of supporting effective intervention by safety software and the crew.

Challenging Aerospace Problems for Intelligent Systems

NASA Technical Reports Server (NTRS)

Krishnakumar, Kalmanje; Kanashige, John; Satyadas, A.; Clancy, Daniel (Technical Monitor)

2002-01-01

In this paper we highlight four problem domains that are well suited and challenging for intelligent system technologies. The problems are defined and an outline of a probable approach is presented. No attempt is made to define the problems as test cases. In other words, no data or set of equations that a user can code and get results are provided. The main idea behind this paper is to motivate intelligent system researchers to examine problems that will elevate intelligent system technologies and applications to a higher level.

Pharmacotherapy for Adults with Tumors of the Central Nervous System

PubMed Central

Schor, Nina F.

2009-01-01

Tumors of the adult central nervous system are among the most common and most chemoresistant neoplasms. Malignant tumors of the brain and spinal cord collectively account for approximately 1.3% of all cancers and 2.2% of all cancer-related deaths. Novel pharmacological approaches to nervous system tumors are urgently needed. This review presents the current approaches and challenges to successful pharmacotherapy of adults with malignant tumors of the central nervous system and discusses novel approaches aimed at overcoming these challenges. PMID:19091301

Challenging Aerospace Problems for Intelligent Systems

NASA Technical Reports Server (NTRS)

KrishnaKumar, K.; Kanashige, J.; Satyadas, A.

2003-01-01

In this paper we highlight four problem domains that are well suited and challenging for intelligent system technologies. The problems are defined and an outline of a probable approach is presented. No attempt is made to define the problems as test cases. In other words, no data or set of equations that a user can code and get results are provided. The main idea behind this paper is to motivate intelligent system researchers to examine problems that will elevate intelligent system technologies and applications to a higher level.

Rotorcraft Health Management Issues and Challenges

NASA Technical Reports Server (NTRS)

Zakrajsek, James J.; Dempsey, Paula J.; Huff, Edward M.; Augustin, Michael; Safa-Bakhsh, Robab; Ephraim, Piet; Grabil, Paul; Decker, Harry J.

2006-01-01

This paper presents an overview of health management issues and challenges that are specific to rotorcraft. Rotorcraft form a unique subset of air vehicles in that their propulsion system is used not only for propulsion, but also serves as the primary source of lift and maneuvering of the vehicle. No other air vehicle relies on the propulsion system to provide these functions through a transmission system with single critical load paths without duplication or redundancy. As such, health management of the power train is a critical and unique part of any rotorcraft health management system. This paper focuses specifically on the issues and challenges related to the dynamic mechanical components in the main power train. This includes the transmission and main rotor mechanisms. This paper will review standard practices used for rotorcraft health management, lessons learned from fielded trials, and future challenges.

Engineering of the LISA Pathfinder mission—making the experiment a practical reality

NASA Astrophysics Data System (ADS)

Warren, Carl; Dunbar, Neil; Backler, Mike

2009-05-01

LISA Pathfinder represents a unique challenge in the development of scientific spacecraft—not only is the LISA Test Package (LTP) payload a complex integrated development, placing stringent requirements on its developers and the spacecraft, but the payload also acts as the core sensor and actuator for the spacecraft, making the tasks of control design, software development and system verification unusually difficult. The micro-propulsion system which provides the remaining actuation also presents substantial development and verification challenges. As the mission approaches the system critical design review, flight hardware is completing verification and the process of verification using software and hardware simulators and test benches is underway. Preparation for operations has started, but critical milestones for LTP and field effect electric propulsion (FEEP) lie ahead. This paper summarizes the status of the present development and outlines the key challenges that must be overcome on the way to launch.

Calculation of surface potentials at the silica–water interface using molecular dynamics: Challenges and opportunities

NASA Astrophysics Data System (ADS)

Lowe, Benjamin M.; Skylaris, Chris-Kriton; Green, Nicolas G.; Shibuta, Yasushi; Sakata, Toshiya

2018-04-01

Continuum-based methods are important in calculating electrostatic properties of interfacial systems such as the electric field and surface potential but are incapable of providing sufficient insight into a range of fundamentally and technologically important phenomena which occur at atomistic length-scales. In this work a molecular dynamics methodology is presented for interfacial electric field and potential calculations. The silica–water interface was chosen as an example system, which is highly relevant for understanding the response of field-effect transistors sensors (FET sensors). Detailed validation work is presented, followed by the simulated surface charge/surface potential relationship. This showed good agreement with experiment at low surface charge density but at high surface charge density the results highlighted challenges presented by an atomistic definition of the surface potential. This methodology will be used to investigate the effect of surface morphology and biomolecule addition; both factors which are challenging using conventional continuum models.

Exploration Rover Concepts and Development Challenges

NASA Technical Reports Server (NTRS)

Zakrajsek, James J.; McKissock, David B.; Woytach, Jeffrey M.; Zakrajsek, June F.; Oswald, Fred B.; McEntire, Kelly J.; Hill, Gerald M.; Abel, Phillip; Eichenberg, Dennis J.; Goodnight, Thomas W.

2005-01-01

This paper presents an overview of exploration rover concepts and the various development challenges associated with each as they are applied to exploration objectives and requirements for missions on the Moon and Mars. A variety of concepts for surface exploration vehicles have been proposed since the initial development of the Apollo-era lunar rover. This paper provides a brief description of the rover concepts, along with a comparison of their relative benefits and limitations. In addition, this paper outlines, and investigates a number of critical development challenges that surface exploration vehicles must address in order to successfully meet the exploration mission vision. These include: mission and environmental challenges, design challenges, and production and delivery challenges. Mission and environmental challenges include effects of terrain, extreme temperature differentials, dust issues, and radiation protection. Design methods are discussed that focus on optimum methods for developing highly reliable, long-life and efficient systems. In addition, challenges associated with delivering a surface exploration system is explored and discussed. Based on all the information presented, modularity will be the single most important factor in the development of a truly viable surface mobility vehicle. To meet mission, reliability, and affordability requirements, surface exploration vehicles, especially pressurized rovers, will need to be modularly designed and deployed across all projected Moon and Mars exploration missions.

Computer-assisted diagnostic decision support: history, challenges, and possible paths forward.

PubMed

Miller, Randolph A

2009-09-01

This paper presents a brief history of computer-assisted diagnosis, including challenges and future directions. Some ideas presented in this article on computer-assisted diagnostic decision support systems (CDDSS) derive from prior work by the author and his colleagues (see list in Acknowledgments) on the INTERNIST-1 and QMR projects. References indicate the original sources of many of these ideas.

Materials and structures technology insertion into spacecraft systems: Successes and challenges

NASA Astrophysics Data System (ADS)

Rawal, Suraj

2018-05-01

Over the last 30 years, significant advancements have led to the use of multifunctional materials and structures technologies in spacecraft systems. This includes the integration of adaptive structures, advanced composites, nanotechnology, and additive manufacturing technologies. Development of multifunctional structures has been directly influenced by the implementation of processes and tools for adaptive structures pioneered by Prof. Paolo Santini. Multifunctional materials and structures incorporating non-structural engineering functions such as thermal, electrical, radiation shielding, power, and sensors have been investigated. The result has been an integrated structure that offers reduced mass, packaging volume, and ease of integration for spacecraft systems. Current technology development efforts are being conducted to develop innovative multifunctional materials and structures designs incorporating advanced composites, nanotechnology, and additive manufacturing. However, these efforts offer significant challenges in the qualification and acceptance into spacecraft systems. This paper presents a brief overview of the technology development and successful insertion of advanced material technologies into spacecraft structures. Finally, opportunities and challenges to develop and mature next generation advanced materials and structures are presented.

Robotic System for Condition Assessment of Concrete Bridge Decks : Data Driven Decisions [Tech Brief

DOT National Transportation Integrated Search

2012-12-11

In the United States, the stewardship and management of approximately 599,000 bridges present ongoing planning, operational, maintenance, and economic challenges for Federal, State, and local transportation agencies. To help overcome these challenges...

The Challenges of Developing a Food System for a Mars Mission

NASA Technical Reports Server (NTRS)

Perchonok, Michele

2007-01-01

A viewgraph describing the food system that NASA is developing for Manned Mars Missions is shown. The topics include: 1) The President's Vision for U.S. Space Exploration -January 14, 2004; 2) Introducing Orion (and Ares); 3) Mercury (1961-1963); 4) Gemini (1965-1966); 5) Apollo (1968-1972); 6) Skylab (1973-1974); 7) Shuttle/Mir (1995-1998); 8) Shuttle (1981-present) International Space Station (2000-present); 9) NASA Stored Food System; 10) Advanced Food Technology; 11) Orion Missions; 12) Orion Challenges; 13) Food Packaging; 14) Mars Mission Assumptions; 15) Planetary Food System Selected Crops; 16) Food Processing Equipment Constraints; 17) Crew Involvement Constraints; 18) Advanced Food Technology Integration; 19) Research Highlights Internal; and 20) Research Highlights External.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zitney, S.E.

Emerging fossil energy power generation systems must operate with unprecedented efficiency and near-zero emissions, while optimizing profitably amid cost fluctuations for raw materials, finished products, and energy. To help address these challenges, the fossil energy industry will have to rely increasingly on the use advanced computational tools for modeling and simulating complex process systems. In this paper, we present the computational research challenges and opportunities for the optimization of fossil energy power generation systems across the plant lifecycle from process synthesis and design to plant operations. We also look beyond the plant gates to discuss research challenges and opportunities formore » enterprise-wide optimization, including planning, scheduling, and supply chain technologies.« less

Man-systems distributed system for Space Station Freedom

NASA Technical Reports Server (NTRS)

Lewis, J. L.

1990-01-01

Viewgraphs on man-systems distributed system for Space Station Freedom are presented. Topics addressed include: description of man-systems (definition, requirements, scope, subsystems, and topologies); implementation (approach, tools); man-systems interfaces (system to element and system to system); prime/supporting development relationship; selected accomplishments; and technical challenges.

Innovation in Extraterrestrial Service Systems - A Challenge for Service Science

NASA Technical Reports Server (NTRS)

Bergner, David

2010-01-01

This presentation was prepared at the invitation of Professor Yukio Ohsawa, Department of Systems Innovation, School of Engineering, The University of Tokyo, for delivery at the International Workshop on Innovating Service Systems, sponsored by the Japanese Society of Artificial Intelligence (JSAI) as part of the JSAI Internation Symposium on AI, 2010. It offers several challenges for Service Science and Service Innovation. the goal of the presentation is to stimulate thinking about how service systems viII evolve in the future, as human society advances from its terrestrial base toward a permanent presence in space. First we will consider the complexity of the International Space Station (ISS) as it is today, with particular emphasis of its research facilities, and focus on a current challenge - to maximize the utilization of ISS research facilities for the benefit of society. After briefly reviewing the basic principles of Service Science, we will discuss the potential application of Service Innovation methodology to this challenge. Then we viII consider how game-changing technologies - in particular Synthetic Biology - could accelerate the pace of sociocultural evolution and consequently, the progression of human society into space. We will use this provocative vision to advance thinking about how the emerging field of Service Science, Management, and Engineering (SSME) might help us anticipate and better handle the challenges of this inevitable evolutionary process.

Information Systems for Government and Business: Trends, Issues, Challenges. Proceedings of the Kawasaki International Seminar on the Information Systems Challenge for Government and Business (2nd, Kawasaki City, Japan, July 21-24, 1987).

ERIC Educational Resources Information Center

United Nations Centre for Regional Development, Nagoya (Japan).

The 25 papers in this proceedings were presented by national and international information systems experts, development planners, and scholars at a seminar that was jointly sponsored by the United Nations Centre for Regional Development and the city of Kawasaki, Japan. Designed to reach a wider group of interested planning practitioners and…

Some Challenges in the Design of Human-Automation Interaction for Safety-Critical Systems

NASA Technical Reports Server (NTRS)

Feary, Michael S.; Roth, Emilie

2014-01-01

Increasing amounts of automation are being introduced to safety-critical domains. While the introduction of automation has led to an overall increase in reliability and improved safety, it has also introduced a class of failure modes, and new challenges in risk assessment for the new systems, particularly in the assessment of rare events resulting from complex inter-related factors. Designing successful human-automation systems is challenging, and the challenges go beyond good interface development (e.g., Roth, Malin, & Schreckenghost 1997; Christoffersen & Woods, 2002). Human-automation design is particularly challenging when the underlying automation technology generates behavior that is difficult for the user to anticipate or understand. These challenges have been recognized in several safety-critical domains, and have resulted in increased efforts to develop training, procedures, regulations and guidance material (CAST, 2008, IAEA, 2001, FAA, 2013, ICAO, 2012). This paper points to the continuing need for new methods to describe and characterize the operational environment within which new automation concepts are being presented. We will describe challenges to the successful development and evaluation of human-automation systems in safety-critical domains, and describe some approaches that could be used to address these challenges. We will draw from experience with the aviation, spaceflight and nuclear power domains.

Central nervous system Aspergillus infection after epidural analgesia: diagnosis, therapeutic challenges, and literature review

PubMed Central

Genzen, Jonathan R.; Kenney, Barton

2009-01-01

Aspergillus terreus was identified in an intra-dural spinal biopsy specimen from an African female with recurrent headache and hydrocephalus. Prior laboratory testing of cerebrospinal fluid (CSF) was non-diagnostic, despite extensive central nervous system (CNS) involvement. CNS Aspergillus infection presents a diagnostic and therapeutic challenge and is reviewed in the context of this particularly instructive and difficult case. PMID:19717262

A Tightening of the Screws: The Politics of School Finance in Florida. State of the States 1995.

ERIC Educational Resources Information Center

Herrington, Carolyn D.; Nakib, Yasser A.

Florida's education system must creatively confront a number of challenges if it is to fulfill its obligation to the state's students. This paper presents an overview of challenges to the Florida school system in 1995, some of which include rising student enrollment, an increase in racial and ethnic minority populations, and a tax base that is…

The Challenges to Coupling Dynamic Geospatial Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldstein, N

2006-06-23

Many applications of modeling spatial dynamic systems focus on a single system and a single process, ignoring the geographic and systemic context of the processes being modeled. A solution to this problem is the coupled modeling of spatial dynamic systems. Coupled modeling is challenging for both technical reasons, as well as conceptual reasons. This paper explores the benefits and challenges to coupling or linking spatial dynamic models, from loose coupling, where information transfer between models is done by hand, to tight coupling, where two (or more) models are merged as one. To illustrate the challenges, a coupled model of Urbanizationmore » and Wildfire Risk is presented. This model, called Vesta, was applied to the Santa Barbara, California region (using real geospatial data), where Urbanization and Wildfires occur and recur, respectively. The preliminary results of the model coupling illustrate that coupled modeling can lead to insight into the consequences of processes acting on their own.« less

Considering Intermittent Dormancy in an Advanced Life Support Systems Architecture

NASA Technical Reports Server (NTRS)

Sargusingh, Miriam J.; Perry, Jay L.

2017-01-01

Many advanced human space exploration missions being considered by the National Aeronautics and Space Administration (NASA) include concepts in which in-space systems cycle between inhabited and uninhabited states. Managing the life support system (LSS) may be particularly challenged during these periods of intermittent dormancy. A study to identify LSS management challenges and considerations relating to dormancy is described. The study seeks to define concepts suitable for addressing intermittent dormancy states and to evaluate whether the reference LSS architectures being considered by the Advanced Exploration Systems (AES) Life Support Systems Project (LSSP) are sufficient to support this operational state. The primary focus of the study is the mission concept considered to be the most challenging-a crewed Mars mission with an extensive surface stay. Results from this study are presented and discussed.

Computational dynamic approaches for temporal omics data with applications to systems medicine.

PubMed

Liang, Yulan; Kelemen, Arpad

2017-01-01

Modeling and predicting biological dynamic systems and simultaneously estimating the kinetic structural and functional parameters are extremely important in systems and computational biology. This is key for understanding the complexity of the human health, drug response, disease susceptibility and pathogenesis for systems medicine. Temporal omics data used to measure the dynamic biological systems are essentials to discover complex biological interactions and clinical mechanism and causations. However, the delineation of the possible associations and causalities of genes, proteins, metabolites, cells and other biological entities from high throughput time course omics data is challenging for which conventional experimental techniques are not suited in the big omics era. In this paper, we present various recently developed dynamic trajectory and causal network approaches for temporal omics data, which are extremely useful for those researchers who want to start working in this challenging research area. Moreover, applications to various biological systems, health conditions and disease status, and examples that summarize the state-of-the art performances depending on different specific mining tasks are presented. We critically discuss the merits, drawbacks and limitations of the approaches, and the associated main challenges for the years ahead. The most recent computing tools and software to analyze specific problem type, associated platform resources, and other potentials for the dynamic trajectory and interaction methods are also presented and discussed in detail.

World weather program

NASA Technical Reports Server (NTRS)

1980-01-01

A brief description of the Global Weather Experiment is presented. The world weather watch program plan is described and includes a global observing system, a global data processing system, a global telecommunication system, and a voluntary cooperation program. A summary of Federal Agency plans and programs to meet the challenges of international meteorology for the two year period, FY 1980-1981, is presented.

Next-Generation Climate Modeling Science Challenges for Simulation, Workflow and Analysis Systems

NASA Astrophysics Data System (ADS)

Koch, D. M.; Anantharaj, V. G.; Bader, D. C.; Krishnan, H.; Leung, L. R.; Ringler, T.; Taylor, M.; Wehner, M. F.; Williams, D. N.

2016-12-01

We will present two examples of current and future high-resolution climate-modeling research that are challenging existing simulation run-time I/O, model-data movement, storage and publishing, and analysis. In each case, we will consider lessons learned as current workflow systems are broken by these large-data science challenges, as well as strategies to repair or rebuild the systems. First we consider the science and workflow challenges to be posed by the CMIP6 multi-model HighResMIP, involving around a dozen modeling groups performing quarter-degree simulations, in 3-member ensembles for 100 years, with high-frequency (1-6 hourly) diagnostics, which is expected to generate over 4PB of data. An example of science derived from these experiments will be to study how resolution affects the ability of models to capture extreme-events such as hurricanes or atmospheric rivers. Expected methods to transfer (using parallel Globus) and analyze (using parallel "TECA" software tools) HighResMIP data for such feature-tracking by the DOE CASCADE project will be presented. A second example will be from the Accelerated Climate Modeling for Energy (ACME) project, which is currently addressing challenges involving multiple century-scale coupled high resolution (quarter-degree) climate simulations on DOE Leadership Class computers. ACME is anticipating production of over 5PB of data during the next 2 years of simulations, in order to investigate the drivers of water cycle changes, sea-level-rise, and carbon cycle evolution. The ACME workflow, from simulation to data transfer, storage, analysis and publication will be presented. Current and planned methods to accelerate the workflow, including implementing run-time diagnostics, and implementing server-side analysis to avoid moving large datasets will be presented.

Supportability Challenges, Metrics, and Key Decisions for Future Human Spaceflight

NASA Technical Reports Server (NTRS)

Owens, Andrew C.; de Weck, Olivier L.; Stromgren, Chel; Cirillo, William; Goodliff, Kandyce

2017-01-01

Future crewed missions beyond Low Earth Orbit (LEO) represent a logistical challenge that is unprecedented in human space flight. Astronauts will travel farther and stay in space for longer than any previous mission, far from timely abort or resupply from Earth. Under these conditions, supportability { defined as the set of system characteristics that influence the logistics and support required to enable safe and effective operations of systems { will be a much more significant driver of space system lifecycle properties than it has been in the past. This paper presents an overview of supportability for future human space flight. The particular challenges of future missions are discussed, with the differences between past, present, and future missions highlighted. The relationship between supportability metrics and mission cost, performance, schedule, and risk is also discussed. A set of pro- posed strategies for managing supportability is presented (including reliability growth, uncertainty reduction, level of repair, commonality, redundancy, In-Space Manufacturing (ISM) (including the use of material recycling and In-Situ Resource Utilization (ISRU) for spares and maintenance items), reduced complexity, and spares inventory decisions such as the use of predeployed or cached spares - along with a discussion of the potential impacts of each of those strategies. References are provided to various sources that describe these supportability metrics and strategies, as well as associated modeling and optimization techniques, in greater detail. Overall, supportability is an emergent system characteristic and a holistic challenge for future system development. System designers and mission planners must carefully consider and balance the supportability metrics and decisions described in this paper in order to enable safe and effective beyond-LEO human space flight.

Mars Science Laboratory Entry, Descent and Landing System Development Challenges and Preliminary Flight Performance

NASA Technical Reports Server (NTRS)

Steltzner, Adam D.; San Martin, A. Miguel; Rivellini, Tommaso P.

2013-01-01

The Mars Science Laboratory project recently landed the Curiosity rover on the surface of Mars. With the success of the landing system, the performance envelope of entry, descent, and landing capabilities has been extended over the previous state of the art. This paper will present an overview of the MSL entry, descent, and landing system, a discussion of a subset of its development challenges, and include a discussion of preliminary results of the flight reconstruction effort.

Cervical cancer data and data systems in limited-resource settings: Challenges and opportunities.

PubMed

Drummond, Jennifer L; Were, Martin C; Arrossi, Silvina; Wools-Kaloustian, Kara

2017-07-01

Appropriate collection and use of health information is critical to the planning, scaling up, and improvement of cervical cancer programs. The health information systems implementation landscape is unique to each country; however, systems serving cervical cancer programs in low-resource settings share characteristics that present common challenges. In response, many programs have taken innovative approaches to generating the quality information needed for decision making. Recent advances in health information technology also provide feasible solutions to challenges. This article draws from the experiences of the authors and from current literature to describe outstanding challenges and promising practices in the implementation of cervical cancer data systems, and to make recommendations for next steps. Recommendations include engaging all stakeholders-including providers, program managers, implementing partners, and donors-in promoting national, district, and community information systems; building on existing systems and processes, as well as introducing new technologies; and evolving data collection and data systems as programs advance. © 2017 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.

Speeding up GW Calculations to Meet the Challenge of Large Scale Quasiparticle Predictions.

PubMed

Gao, Weiwei; Xia, Weiyi; Gao, Xiang; Zhang, Peihong

2016-11-11

Although the GW approximation is recognized as one of the most accurate theories for predicting materials excited states properties, scaling up conventional GW calculations for large systems remains a major challenge. We present a powerful and simple-to-implement method that can drastically accelerate fully converged GW calculations for large systems, enabling fast and accurate quasiparticle calculations for complex materials systems. We demonstrate the performance of this new method by presenting the results for ZnO and MgO supercells. A speed-up factor of nearly two orders of magnitude is achieved for a system containing 256 atoms (1024 valence electrons) with a negligibly small numerical error of ±0.03 eV. Finally, we discuss the application of our method to the GW calculations for 2D materials.

Department of Transportation's intelligent transportation systems (ITS) projects book

DOT National Transportation Integrated Search

2001-01-01

Surface transportation systems in the United States today face a number of significant challenges. Congestion and safety continue to present serious problems in spite of the nations superb roadway systems. Congestion imposes an exorbitant cost on ...

Department of Transportation's intelligent transportation systems (ITS) projects book

DOT National Transportation Integrated Search

2002-01-01

Surface transportation systems in the United States today face a number of significant challenges. Congestion and safety continue to present serious problems in spite of the nations superb roadway systems. Congestion imposes an exorbitant cost on ...

Recent Advances and Future Challenges in Risk-Based Radiation Engineering

NASA Technical Reports Server (NTRS)

Pellish, Jonathan A.

2016-01-01

We cover a top-level introduction to hardness assurance (HA) from a robotic space system perspective, starting at the piece-part level. We discuss error sources inherent to presently-accepted HA practices and why they cause us to be risk-averse. We conclude by reviewing current proposals that move towards more risk-tolerant system design approaches as well as future challenges that will require these advanced techniques.

Mobile Computing and Ubiquitous Networking: Concepts, Technologies and Challenges.

ERIC Educational Resources Information Center

Pierre, Samuel

2001-01-01

Analyzes concepts, technologies and challenges related to mobile computing and networking. Defines basic concepts of cellular systems. Describes the evolution of wireless technologies that constitute the foundations of mobile computing and ubiquitous networking. Presents characterization and issues of mobile computing. Analyzes economical and…

The Challenges in Metadata Management: 20+ Years of ESO Data

NASA Astrophysics Data System (ADS)

Vera, I.; Da Rocha, C.; Dobrzycki, A.; Micol, A.; Vuong, M.

2015-09-01

The European Southern Observatory Science Archive Facility has been in operations for more than 20 years. It contains data produced by ESO telescopes as well as the metadata needed for characterizing and distributing those data. This metadata is used to build the different archive services provided by the Archive. Over these years, services have been added, modified or even decommissioned creating a cocktail of new, evolved and legacy data systems. The challenge for the Archive is to harmonize the differences of those data systems to provide the community with a homogeneous experience when using ESO data. In this paper, we present ESO experience in three particular challenging areas. First discussion is dedicated to the problem of metadata quality over the time, second discusses how to integrate obsolete data models on the current services and finally we will present the challenges of ever growing databases. We describe our experience dealing with those issues and the solutions adopted to mitigate them.

Implementing the Biopharmaceutics Classification System in Drug Development: Reconciling Similarities, Differences, and Shared Challenges in the EMA and US-FDA-Recommended Approaches.

PubMed

Cardot, J-M; Garcia Arieta, A; Paixao, P; Tasevska, I; Davit, B

2016-07-01

The US-FDA recently posted a draft guideline for industry recommending procedures necessary to obtain a biowaiver for immediate-release oral dosage forms based on the Biopharmaceutics Classification System (BCS). This review compares the present FDA BCS biowaiver approach, with the existing European Medicines Agency (EMA) approach, with an emphasis on similarities, difficulties, and shared challenges. Some specifics of the current EMA BCS guideline are compared with those in the recently published draft US-FDA BCS guideline. In particular, similarities and differences in the EMA versus US-FDA approaches to establishing drug solubility, permeability, dissolution, and formulation suitability for BCS biowaiver are critically reviewed. Several case studies are presented to illustrate the (i) challenges of applying for BCS biowaivers for global registration in the face of differences in the EMA and US-FDA BCS biowaiver criteria, as well as (ii) challenges inherent in applying for BCS class I or III designation and common to both jurisdictions.

Distributed Prognostic Health Management with Gaussian Process Regression

NASA Technical Reports Server (NTRS)

Saha, Sankalita; Saha, Bhaskar; Saxena, Abhinav; Goebel, Kai Frank

2010-01-01

Distributed prognostics architecture design is an enabling step for efficient implementation of health management systems. A major challenge encountered in such design is formulation of optimal distributed prognostics algorithms. In this paper. we present a distributed GPR based prognostics algorithm whose target platform is a wireless sensor network. In addition to challenges encountered in a distributed implementation, a wireless network poses constraints on communication patterns, thereby making the problem more challenging. The prognostics application that was used to demonstrate our new algorithms is battery prognostics. In order to present trade-offs within different prognostic approaches, we present comparison with the distributed implementation of a particle filter based prognostics for the same battery data.

The Hubble Space Telescope servicing missions: Past, present, and future operational challenges

NASA Technical Reports Server (NTRS)

Ochs, William R.; Barbehenn, George M.; Crabb, William G.

1996-01-01

The Hubble Space Telescope was designed to be serviced by the Space Shuttle to upgrade systems, replace failed components and boost the telescope into higher orbits. There exists many operational challenges that must be addressed in preparation for the execution of a servicing mission, including technical and managerial issues. The operational challenges faced by the Hubble operations and ground system project for the support of the first servicing mission and future servicing missions, are considered. The emphasis is on those areas that helped ensure the success of the mission, including training, testing and contingency planning.

Social learning in the Anthropocene: Novel challenges, shadow networks, and ethical practices.

PubMed

Schmidt, Jeremy J

2017-05-15

The Anthropocene presents novel challenges for environmental management. This paper considers the challenges that the Anthropocene poses for social learning techniques in adaptive management. It situates these challenges with respect to how anthropogenic forcing on the Earth system affects the conditions required for: (1) The cooperative exercises of social learning; (2) The techniques used for assessing the fit of institutions to social-ecological systems; and, (3) The strategies employed for identifying management targets that are transformed by human action. In view of these challenges, the paper then examines how the practices of shadow networks may provide paths for incorporating a broader, more robust suite of social learning practices in the Anthropocene. The paper emphasizes how novel challenges in the Anthropocene demand increased attention to ethical practices, particularly those that establish center-periphery relationships between social learning communities and shadow networks. Copyright © 2017 Elsevier Ltd. All rights reserved.

Toxcast and the Use of Human Relevant In Vitro Exposures ...

EPA Pesticide Factsheets

The path for incorporating new approach methods and technologies into quantitative chemical risk assessment poses a diverse set of scientific challenges. These challenges include sufficient coverage of toxicological mechanisms to meaningfully interpret negative test results, development of increasingly relevant test systems, computational modeling to integrate experimental data, putting results in a dose and exposure context, characterizing uncertainty, and efficient validation of the test systems and computational models. The presentation will cover progress at the U.S. EPA in systematically addressing each of these challenges and delivering more human-relevant risk-based assessments. This abstract does not necessarily reflect U.S. EPA policy. Presentation at the British Toxicological Society Annual Congress on ToxCast and the Use of Human Relevant In Vitro Exposures: Incorporating high-throughput exposure and toxicity testing data for 21st century risk assessments .

e-Health promises and challenges: some ethical considerations.

PubMed

Kluge, Eike-Henner W

2011-01-01

eHealth is a cost-effective and efficient way of providing health care to patients who would otherwise be excluded or underserviced. However, eHealth also presents a series of ethical and legal challenges which, if not met before its implementation, can undermine its success. Among other things, privacy, consent and liability are implicated, as are changes in the health care professional-patient relationship and in the role of health informatics professionals. Legacy systems and interoperability present further challenges, and outsourcing may pose special problems. This paper highlights some of these issues and outlines their implications.

System requirements for head down and helmet mounted displays in the military avionics environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flynn, M.F.; Kalmanash, M.; Sethna, V.

1996-12-31

The introduction of flat panel display technologies into the military avionics cockpit is a challenging proposition, due to the very difficult system level requirements which must be met. These relate to environmental extremes (temperature and vibrational), sever ambient lighting conditions (10,000 fL to nighttime viewing), night vision system compatibility, and wide viewing angle. At the same time, the display system must be packaged in minimal space and use minimal power. The authors will present details on the display system requirements for both head down and helmet mounted systems, as well as information on how these challenges may be overcome.

Terabit Wireless Communication Challenges

NASA Technical Reports Server (NTRS)

Hwu, Shian U.

2012-01-01

This presentation briefly discusses a research effort on Terabit Wireless communication systems for possible space applications. Recently, terahertz (THz) technology (300-3000 GHz frequency) has attracted a great deal of interest from academia and industry. This is due to a number of interesting features of THz waves, including the nearly unlimited bandwidths available, and the non-ionizing radiation nature which does not damage human tissues and DNA with minimum health threat. Also, as millimeter-wave communication systems mature, the focus of research is, naturally, moving to the THz range. Many scientists regard THz as the last great frontier of the electromagnetic spectrum, but finding new applications outside the traditional niches of radio astronomy, Earth and planetary remote sensing, and molecular spectroscopy particularly in biomedical imaging and wireless communications has been relatively slow. Radiologists find this area of study so attractive because t-rays are non-ionizing, which suggests no harm is done to tissue or DNA. They also offer the possibility of performing spectroscopic measurements over a very wide frequency range, and can even capture signatures from liquids and solids. According to Shannon theory, the broad bandwidth of the THz frequency bands can be used for terabit-per-second (Tb/s) wireless communication systems. This enables several new applications, such as cell phones with 360 degrees autostereoscopic displays, optic-fiber replacement, and wireless Tb/s file transferring. Although THz technology could satisfy the demand for an extremely high data rate, a number of technical challenges need to be overcome before its development. This presentation provides an overview the state-of-the- art in THz wireless communication and the technical challenges for an emerging application in Terabit wireless systems. The main issue for THz wave propagation is the high atmospheric attenuation, which is dominated by water vapor absorption in the THz frequency band. The technical challenges in design such a system and the techniques to overcome the challenges will be discussed in this presentation.

Software Systems for High-performance Quantum Computing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Humble, Travis S; Britt, Keith A

Quantum computing promises new opportunities for solving hard computational problems, but harnessing this novelty requires breakthrough concepts in the design, operation, and application of computing systems. We define some of the challenges facing the development of quantum computing systems as well as software-based approaches that can be used to overcome these challenges. Following a brief overview of the state of the art, we present models for the quantum programming and execution models, the development of architectures for hybrid high-performance computing systems, and the realization of software stacks for quantum networking. This leads to a discussion of the role that conventionalmore » computing plays in the quantum paradigm and how some of the current challenges for exascale computing overlap with those facing quantum computing.« less

In-Space Assembly Capability Assessment for Potential Human Exploration and Science Applications

NASA Technical Reports Server (NTRS)

Jefferies, Sharon A.; Jones, Christopher A.; Arney, Dale C.; Stillwagen, Frederic H.; Chai, Patrick R.; Hutchinson, Craig D.; Stafford, Matthew A.; Moses, Robert W.; Dempsey, James A.; Rodgers, Erica M.;

Challenges in Achieving Trajectory-Based Operations

NASA Technical Reports Server (NTRS)

Cate, Karen Tung

2012-01-01

In the past few years much of the global ATM research community has proposed advanced systems based on Trajectory-Based Operations (TBO). The concept of TBO uses four-dimensional aircraft trajectories as the base information for managing safety and capacity. Both the US and European advanced ATM programs call for the sharing of trajectory data across different decision support tools for successful operations. However, the actual integration of TBO systems presents many challenges. Trajectory predictors are built to meet the specific needs of a particular system and are not always compatible with others. Two case studies are presented which examine the challenges of introducing a new concept into two legacy systems in regards to their trajectory prediction software. The first case describes the issues with integrating a new decision support tool with a legacy operational system which overlap in domain space. These tools perform similar functions but are driven by different requirements. The difference in the resulting trajectories can lead to conflicting advisories. The second case looks at integrating this same new tool with a legacy system originally developed as an integrated system, but diverged many years ago. Both cases illustrate how the lack of common architecture concepts for the trajectory predictors added cost and complexity to the integration efforts.

u-Healthcare system: state-of-the-art review and challenges.

PubMed

Touati, Farid; Tabish, Rohan

2013-06-01

With the increase of an ageing population and chronic diseases, society becomes more health conscious and patients become "health consumers" looking for better health management. People's perception is shifting towards patient-centered, rather than the classical, hospital-centered health services which has been propelling the evolution of telemedicine research from the classic e-Health to m-Health and now is to ubiquitous healthcare (u-Health). It is expected that mobile & ubiquitous Telemedicine, integrated with Wireless Body Area Network (WBAN), have a great potential in fostering the provision of next-generation u-Health. Despite the recent efforts and achievements, current u-Health proposed solutions still suffer from shortcomings hampering their adoption today. This paper presents a comprehensive review of up-to-date requirements in hardware, communication, and computing for next-generation u-Health systems. It compares new technological and technical trends and discusses how they address expected u-Health requirements. A thorough survey on various worldwide recent system implementations is presented in an attempt to identify shortcomings in state-of-the art solutions. In particular, challenges in WBAN and ubiquitous computing were emphasized. The purpose of this survey is not only to help beginners with a holistic approach toward understanding u-Health systems but also present to researchers new technological trends and design challenges they have to cope with, while designing such systems.

10 CFR 50.36 - Technical specifications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... presents a challenge to the integrity of a fission product barrier. (C) Criterion 3. A structure, system... integrity of a fission product barrier. (D) Criterion 4. A structure, system, or component which operating...

Next generation: In-space transportation system(s)

NASA Technical Reports Server (NTRS)

Huffaker, Fredrick; Redus, Jerry; Kelley, David L.

1991-01-01

The development of the next generation In-Space Transportation System presents a unique challenge to the design of a propulsion system for the Space Exploration Initiative (SEI). Never before have the requirements for long-life, multiple mission use, space basing, high reliability, man-rating, and minimum maintenance come together with performance in one system that must protect the lives of space travelers, support the mission logistics needs, and do so at an acceptable cost. The challenge that is presented is to quantify the bounds of these requirements. The issue is one of degree. The length of acceptable life in space, the time it takes for reuse to pay off, and the degree to which space basing is practical (full, partial, or expended) are the issues that determine the reusable bounds of a design and include dependability, contingency capabilities, resilency, and minimum dependence on a maintenance node in preparation for and during a mission. Missions to planet earth, other non-NASA missions, and planetary missions will provide important but less demanding requirements for the transportation systems of the future. The mission proposed for the SEI require a family of transportation vehicles to meet the requirements for establishing a permanent human presence on the Moon and eventually on Mars. Specialized vehicles are needed to accomplish the different phases of each mission. These large scale missions require assembly in space and will provide the greatest usage of the planned integrated transportation system. The current approach to defining the In-Space Transportation System for the SEI Moon missions with later Mars mission applications is presented. Several system development options, propulsion concepts, current/proposed activities are reviewed, and key propulsion design criteria, issues, and technology challenges for the next generation In-Space Transportation System(s) are outlined.

Focus Upon Implementing the GGOS Decadal Vision for Geohazards Monitoring

NASA Astrophysics Data System (ADS)

LaBrecque, John; Stangl, Gunter

2017-04-01

The Global Geodetic Observing System of the IAG identified present and future roles for Geodesy in the development and well being of the global society. The GGOS is focused upon the development of infrastructure, information, analysis, and educational systems to advance the International Global Reference Frame, the International Celestial Reference System, the International Height Reference System, atmospheric dynamics, sea level change and geohazards monitoring. The geohazards initiative is guided by an eleven nation working group initially focused upon the development and integration of regional multi-GNSS networks and analysis systems for earthquake and tsunami early warning. The opportunities and challenges being addressed by the Geohazards working group include regional network design, algorithm development and implementation, communications, funding, and international agreements on data access. This presentation will discuss in further detail these opportunities and challenges for the GGOS focus upon earthquake and tsunami early warning.

Challenges to Cabin Humidity Removal Presented by Intermittent Condensing Conditions

NASA Technical Reports Server (NTRS)

vonJouanne, Roger G.; Williams, David E.

2007-01-01

On-orbit temperature and humidity control (THC) is more easily accomplished when the THC hardware is either consistently dry (i.e., no humidity control is occurring), or consistently wet. The system is especially challenged when intermittent wet/dry conditions occur. The first six years of on-orbit ISS operations have revealed specific concerns within the THC system, specifically in the condensing heat exchanger and the downstream air/water separator. Failed or degraded hardware has been returned to ground and investigated. This paper presents the investigation findings, and the recommended hardware and procedural revisions to prevent and recover from the effects of intermittent condensing conditions.

Linear Temporal Logic (LTL) Based Monitoring of Smart Manufacturing Systems.

PubMed

Heddy, Gerald; Huzaifa, Umer; Beling, Peter; Haimes, Yacov; Marvel, Jeremy; Weiss, Brian; LaViers, Amy

2015-01-01

The vision of Smart Manufacturing Systems (SMS) includes collaborative robots that can adapt to a range of scenarios. This vision requires a classification of multiple system behaviors, or sequences of movement, that can achieve the same high-level tasks. Likewise, this vision presents unique challenges regarding the management of environmental variables in concert with discrete, logic-based programming. Overcoming these challenges requires targeted performance and health monitoring of both the logical controller and the physical components of the robotic system. Prognostics and health management (PHM) defines a field of techniques and methods that enable condition-monitoring, diagnostics, and prognostics of physical elements, functional processes, overall systems, etc. PHM is warranted in this effort given that the controller is vulnerable to program changes, which propagate in unexpected ways, logical runtime exceptions, sensor failure, and even bit rot. The physical component's health is affected by the wear and tear experienced by machines constantly in motion. The controller's source of faults is inherently discrete, while the latter occurs in a manner that builds up continuously over time. Such a disconnect poses unique challenges for PHM. This paper presents a robotic monitoring system that captures and resolves this disconnect. This effort leverages supervisory robotic control and model checking with linear temporal logic (LTL), presenting them as a novel monitoring system for PHM. This methodology has been demonstrated in a MATLAB-based simulator for an industry inspired use-case in the context of PHM. Future work will use the methodology to develop adaptive, intelligent control strategies to evenly distribute wear on the joints of the robotic arms, maximizing the life of the system.

Towards large-scale data analysis: challenges in the design of portable systems and use of Cloud computing.

PubMed

Diaz, Javier; Arrizabalaga, Saioa; Bustamante, Paul; Mesa, Iker; Añorga, Javier; Goya, Jon

2013-01-01

Portable systems and global communications open a broad spectrum for new health applications. In the framework of electrophysiological applications, several challenges are faced when developing portable systems embedded in Cloud computing services. In order to facilitate new developers in this area based on our experience, five areas of interest are presented in this paper where strategies can be applied for improving the performance of portable systems: transducer and conditioning, processing, wireless communications, battery and power management. Likewise, for Cloud services, scalability, portability, privacy and security guidelines have been highlighted.

Mapping a Path to Autonomous Flight in the National Airspace

NASA Technical Reports Server (NTRS)

Lodding, Kenneth N.

2011-01-01

The introduction of autonomous flight, whether military, commercial, or civilian, into the National Airspace System (NAS) will present significant challenges. Minimizing the impact and preventing the changes from becoming disruptive, rather than an enhancing technology will not be without difficulty. From obstacle detection and avoidance to real-time verification and validation of system behavior, there are significant problems which must be solved prior to the general acceptance of autonomous systems. This paper examines some of the key challenges and the multi-disciplinary collaboration which must occur for autonomous systems to be accepted as equal partners in the NAS.

A Trusted Platform for Transportation Data Sharing & Stakeholder Engagement

DOT National Transportation Integrated Search

2018-03-01

Information sharing to support critical transportation systems presents numerous challenges given the diversity of information sources and visual representations typically used to portray system performance and characteristics12. This research projec...

Integrated approaches to long-term studies of urban ecological systems

Treesearch

Nancy B. Grimm; J. Morgan Grove; Steward T.A. Pickett; Charles L. Redman

2000-01-01

Urban ecological systems present multiple challenges to ecologists—pervasive human impact and extreme heterogeneity of cities, and the need to integrate social and ecological approaches, concepts, and theory.

An Electronic Dictionary and Translation System for Murrinh-Patha

ERIC Educational Resources Information Center

Seiss, Melanie; Nordlinger, Rachel

2012-01-01

This paper presents an electronic dictionary and translation system for the Australian language Murrinh-Patha. Its complex verbal structure makes learning Murrinh-Patha very difficult. Design learning materials or a dictionary which is easy to understand and to use also presents a challenge. This paper discusses some of the difficulties posed by…

Effective use patterns for HPPD herbicides in non-transgenic conservation tillage sweet corn.

USDA-ARS?s Scientific Manuscript database

Weed control is still a challenge in non-transgenic sweet corn due to the suite of weeds present (including wild proso millet and triazine resistant species) and conservation tillage systems that are evolving to meet challenges of environmental stewardship and increasing input costs, mainly the risi...

Tiered Evaluation in Large Ensemble Settings.

ERIC Educational Resources Information Center

Scott, David

1998-01-01

Discusses the use of a tiered evaluation system (TES) that allows students to work at different levels, enables teachers to assess progress objectively, and presents students with appropriate challenges in the music ensembles. Focuses on how TES works and its advantages, considers the challenges and flexibility of TES, and provides samples. (CMK)

Certification of lightning protection for a full-authority digital engine control

NASA Technical Reports Server (NTRS)

Dargi, M.; Rupke, E.; Wiles, K.

1991-01-01

FADEC systems present many challenges to the lightning protection engineer. Verification of the protection-design adequacy for certification purposes presents additional challenges. The basic requirements of the certification plan of a FADEC is to demonstrate compliance with Federal Airworthiness Regulations (FAR) 25.1309 and 25.581. These FARs are intended for transport aircraft, but there are equivalent sections for general aviation aircraft, normal and transport rotorcraft. Military aircraft may have additional requirements. The criteria for demonstration of adequate lightning protection for a FADEC systems include the procedures outlined in FAA Advisory Circular (AC) 20-136, Protection of aircraft electrical/electronic systems against the indirect effects of lightning. As FADEC systems, including the interconnecting wiring, are generally not susceptible to direct attachment of lightning currents, the verification of protection against indirect effects is primarily described.

Deployment Process, Mechanization, and Testing for the Mars Exploration Rovers

NASA Technical Reports Server (NTRS)

Iskenderian, Ted

2004-01-01

NASA's Mar Exploration Rover (MER) robotic prospectors were produced in an environment of unusually challenging schedule, volume, and mass restrictions. The technical challenges pushed the system s design towards extensive integration of function, which resulted in complex system engineering issues. One example of the system's integrated complexity can be found in the deployment process for the rover. Part of this process, rover "standup", is outlined in this paper. Particular attention is given to the Rover Lift Mechanism's (RLM) role and its design. Analysis methods are presented and compared to test results. It is shown that because prudent design principles were followed, a robust mechanism was created that minimized the duration of integration and test, and enabled recovery without perturbing related systems when reasonably foreseeable problems did occur. Examples of avoidable, unnecessary difficulty are also presented.

Speeding up GW Calculations to Meet the Challenge of Large Scale Quasiparticle Predictions

PubMed Central

Gao, Weiwei; Xia, Weiyi; Gao, Xiang; Zhang, Peihong

2016-01-01

Although the GW approximation is recognized as one of the most accurate theories for predicting materials excited states properties, scaling up conventional GW calculations for large systems remains a major challenge. We present a powerful and simple-to-implement method that can drastically accelerate fully converged GW calculations for large systems, enabling fast and accurate quasiparticle calculations for complex materials systems. We demonstrate the performance of this new method by presenting the results for ZnO and MgO supercells. A speed-up factor of nearly two orders of magnitude is achieved for a system containing 256 atoms (1024 valence electrons) with a negligibly small numerical error of ±0.03 eV. Finally, we discuss the application of our method to the GW calculations for 2D materials. PMID:27833140

Motion control of multi-actuator hydraulic systems for mobile machineries: Recent advancements and future trends

NASA Astrophysics Data System (ADS)

Xu, Bing; Cheng, Min

2018-06-01

This paper presents a survey of recent advancements and upcoming trends in motion control technologies employed in designing multi-actuator hydraulic systems for mobile machineries. Hydraulic systems have been extensively used in mobile machineries due to their superior power density and robustness. However, motion control technologies of multi-actuator hydraulic systems have faced increasing challenges due to stringent emission regulations. In this study, an overview of the evolution of existing throttling control technologies is presented, including open-center and load sensing controls. Recent advancements in energy-saving hydraulic technologies, such as individual metering, displacement, and hybrid controls, are briefly summarized. The impact of energy-saving hydraulic technologies on dynamic performance and control solutions are also discussed. Then, the advanced operation methods of multi-actuator mobile machineries are reviewed, including coordinated and haptic controls. Finally, challenges and opportunities of advanced motion control technologies are presented by providing an overall consideration of energy efficiency, controllability, cost, reliability, and other aspects.

Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities.

PubMed

Quo, Chang F; Kaddi, Chanchala; Phan, John H; Zollanvari, Amin; Xu, Mingqing; Wang, May D; Alterovitz, Gil

2012-07-01

Recent advances in high-throughput biotechnologies have led to the rapid growing research interest in reverse engineering of biomolecular systems (REBMS). 'Data-driven' approaches, i.e. data mining, can be used to extract patterns from large volumes of biochemical data at molecular-level resolution while 'design-driven' approaches, i.e. systems modeling, can be used to simulate emergent system properties. Consequently, both data- and design-driven approaches applied to -omic data may lead to novel insights in reverse engineering biological systems that could not be expected before using low-throughput platforms. However, there exist several challenges in this fast growing field of reverse engineering biomolecular systems: (i) to integrate heterogeneous biochemical data for data mining, (ii) to combine top-down and bottom-up approaches for systems modeling and (iii) to validate system models experimentally. In addition to reviewing progress made by the community and opportunities encountered in addressing these challenges, we explore the emerging field of synthetic biology, which is an exciting approach to validate and analyze theoretical system models directly through experimental synthesis, i.e. analysis-by-synthesis. The ultimate goal is to address the present and future challenges in reverse engineering biomolecular systems (REBMS) using integrated workflow of data mining, systems modeling and synthetic biology.

The "big bang" implementation: not for the faint of heart.

PubMed

Anderson, Linda K; Stafford, Cynthia J

2002-01-01

Replacing a hospital's obsolete mainframe computer system with a modern integrated clinical and administrative information system presents multiple challenges. When the new system is activated in one weekend, in "big bang" fashion, the challenges are magnified. Careful planning is essential to ensure that all hospital staff are fully prepared for this transition, knowing this conversion will involve system downtime, procedural changes, and the resulting stress that naturally accompanies change. Implementation concerns include staff preparation and training, process changes, continuity of patient care, and technical and administrative support. This article outlines how the University of Missouri Health Care addressed these operational concerns during this dramatic information system conversion.

Challenges to modeling the Sun-Earth System: A Workshop Summary

NASA Technical Reports Server (NTRS)

Spann, James F.

2006-01-01

This special issue of the Journal of' Atmospheric and Solar-Terrestrial Physics is a compilation of 23 papers presented at The 2004 Huntsville Modeling Workshop: Challenges to Modeling thc San-Earth System held in Huntsville, AB on October 18-22, 2004. The title of the workshop appropriately captures the theme of what was presented and discussed by the 120 participants. Currently, end-to-end modeling of the Sun-Earth system is a major goal of the National Space Weather and NASA living with a star (LWS) programs. While profound advances have been made in modeling isolated regions of the Sun-Earth system, minimal progress has been achieved in modeling the end-to-end system. The transfer of mass, energy and momentum through the coupled Sun-Earth system spans a wide range of scales inn time and space. The uncertainty in the underlying physics responsible for coupling contiguous regions of the Sun-Earth system is recognized as a significant barrier to progress

Fall prevention intervention technologies: A conceptual framework and survey of the state of the art.

PubMed

Hamm, Julian; Money, Arthur G; Atwal, Anita; Paraskevopoulos, Ioannis

2016-02-01

In recent years, an ever increasing range of technology-based applications have been developed with the goal of assisting in the delivery of more effective and efficient fall prevention interventions. Whilst there have been a number of studies that have surveyed technologies for a particular sub-domain of fall prevention, there is no existing research which surveys the full spectrum of falls prevention interventions and characterises the range of technologies that have augmented this landscape. This study presents a conceptual framework and survey of the state of the art of technology-based fall prevention systems which is derived from a systematic template analysis of studies presented in contemporary research literature. The framework proposes four broad categories of fall prevention intervention system: Pre-fall prevention; Post-fall prevention; Fall injury prevention; Cross-fall prevention. Other categories include, Application type, Technology deployment platform, Information sources, Deployment environment, User interface type, and Collaborative function. After presenting the conceptual framework, a detailed survey of the state of the art is presented as a function of the proposed framework. A number of research challenges emerge as a result of surveying the research literature, which include a need for: new systems that focus on overcoming extrinsic falls risk factors; systems that support the environmental risk assessment process; systems that enable patients and practitioners to develop more collaborative relationships and engage in shared decision making during falls risk assessment and prevention activities. In response to these challenges, recommendations and future research directions are proposed to overcome each respective challenge. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

REHABILITATION OF AGING WATER INFRASTRUCTURE SYSTEMS: KEY CHALLENGES AND ISSUES

EPA Science Inventory

Presented in this paper are the results of a state-of-the-practice survey on the rehabilitation of water distribution and wastewater collection systems. The survey identified several needs, including the need for rational and common design approaches for rehabilitation systems, ...

Modernization of the Cassini Ground System

NASA Technical Reports Server (NTRS)

Razo, Gus; Fujii, Tammy J.

2014-01-01

The Cassini Spacecraft and its ground system have been operational for over 16 years. Modernization presents several challenges due to the personnel, processes, and tools already invested and embedded into the current ground system structure. Every mission's ground system has its own unique complexities and challenges, involving various organizational units. As any mission from its inception to its execution, schedules are always tight. This forces GDS engineers to implement a working ground system that is not necessarily fully optimized. Ground system challenges increase as technology evolves and cyber threats become more sophisticated. Cassini's main challenges were due to its ground system existing before many security requirements were levied on the multi-mission tools and networks. This caused a domino effect on Cassini GDS tools that relied on outdated technological features. In the aerospace industry reliable and established technology is preferred over innovative yet less proven technology. Loss of data for a spacecraft mission can be catastrophic; therefore, there is a reluctance to make changes and updates to the ground system. Nevertheless, all missions and associated teams face the need to modernize their processes and tools. Systems development methods from well-known system analysis and design principles can be applied to many missions' ground systems. Modernization should always be considered, but should be done in such a way that it does not affect flexibility nor interfere with established practices. Cassini has accomplished a secure and efficient ground data system through periodic updates. The obstacles faced while performing the modernization of the Cassini ground system will be outlined, as well as the advantages and challenges that were encountered.

Compact Eucapnic Voluntary Hyperpnoea Apparatus for Exercise-Induced Respiratory Disease Detection

PubMed Central

Wang, Lulu; Al-Jumaily, Ahmed

2017-01-01

Eucapnic voluntary hyperpnoea (EVH) challenge provides objective criteria for exercise-induced asthma (EIA) or exercise-induced bronchoconstriction (EIB), and it was recommended to justify the use of inhaled β2-agonists by athletes for the Olympics. This paper presents the development of a compact and easy-to-use EVH apparatus for assessing EIB in human subjects. The compact apparatus has been validated on human subjects and the results have been compared to the conventional EVH system. Twenty-two swimmers, including eleven healthy subjects and eleven subjects who had been physician-diagnosed with asthma, were recruited from sport and recreation centers throughout Auckland, New Zealand. Each subject performed two EVH challenge tests using the proposed breathing apparatus and the conventional Phillips EVH apparatus on separate days, respectively. Forced expiratory volume in one second (FEV1) was measured before and after the challenges. A reduction in FEV1 of 10% or more was considered positive. Of the eleven subjects who were previously diagnosed with asthma, EIB was present in all subjects (100%) in the compact EVH group, while it was presented in ten subjects (90.91%) in the conventional EVH challenge group. Of the eleven healthy subjects, EIB was present in one subject (4.55%) in the compact EVH group, while it was not present in the conventional EVH group. Experimental results showed that the compact EVH system has potential to become an alternative tool for EIB detection. PMID:28509868

Future evolution of distributed systems for smart grid - The challenges and opportunities to using decentralized energy system

NASA Astrophysics Data System (ADS)

Konopko, Joanna

2015-12-01

A decentralized energy system is a relatively new approach in the power industry. Decentralized energy systems provide promising opportunities for deploying renewable energy sources locally available as well as for expanding access to clean energy services to remote communities. The electricity system of the future must produce and distribute electricity that is reliable and affordable. To accomplish these goals, both the electricity grid and the existing regulatory system must be smarter. In this paper, the major issues and challenges in distributed systems for smart grid are discussed and future trends are presented. The smart grid technologies and distributed generation systems are explored. A general overview of the comparison of the traditional grid and smart grid is also included.

The data acquisition and reduction challenge at the Large Hadron Collider.

PubMed

Cittolin, Sergio

2012-02-28

The Large Hadron Collider detectors are technological marvels-which resemble, in functionality, three-dimensional digital cameras with 100 Mpixels-capable of observing proton-proton (pp) collisions at the crossing rate of 40 MHz. Data handling limitations at the recording end imply the selection of only one pp event out of each 10(5). The readout and processing of this huge amount of information, along with the selection of the best approximately 200 events every second, is carried out by a trigger and data acquisition system, supplemented by a sophisticated control and monitor system. This paper presents an overview of the challenges that the development of these systems has presented over the past 15 years. It concludes with a short historical perspective, some lessons learnt and a few thoughts on the future.

Barriers, Challenges, and Decision-Making in the Letter Writing Process for Gender Transition.

PubMed

Budge, Stephanie L; Dickey, Lore M

2017-03-01

This article addresses the challenges that clinicians face in writing letters of support for transgender and gender-diverse clients. It addresses common but challenging clinical representations to help the reader understand the nuances associated with writing letters. Three cases are presented. The first addresses systemic challenges, the second addresses management of care, and the third addresses co-occurring mental health concerns. Recommendations for practice are provided based on the experiences included within the 3 case examples. Copyright © 2016 Elsevier Inc. All rights reserved.

Healthcare-associated infections: challenges to public health in Brazil.

PubMed

Padoveze, Maria Clara; Fortaleza, Carlos Magno Castelo Branco

2014-12-01

This study presents a critical evaluation of the scientific literature related to this subject, aiming to assess the policies and administrative issues regarding the prevention and magnitude of healthcare-associated infections and discuss the challenges for their prevention in Brazil. The topics discussed included historical and administrative issues, challenges imposed by the characteristics of the healthcare system and the territorial dimension, laboratorial support limitations, costs, institutional culture, professional qualification, and patient engagement. It is urgent to hold a nationwide discussion among government representatives, institutions, and healthcare workers and users to overcome these challenges.

Interventions for Children with Autism Spectrum Disorders in Inclusive School Settings

ERIC Educational Resources Information Center

Koegel, Lynn; Matos-Freden, Rosy; Lang, Russell; Koegel, Robert

2012-01-01

Students with ASD present unique challenges to school systems. Despite these challenges, federal laws require that schools implement research-based practices in the least restrictive environment (LRE). The LRE is often deemed to be the general education classroom and the primary intervention agent is often the classroom teacher. Ensuring students…

A Case Study of Online Degree Course Design and Performance of Online Learners

ERIC Educational Resources Information Center

Saul, Robert

2013-01-01

The increasing demand of learners in online higher education courses currently presents a challenge to online course designs in increasing the performance of learners. The online course design process involves many challenges, including a new delivery system, understanding online drivers for success, and an emerging profession of online…

The Case for Teachers' Classroom English Proficiency

ERIC Educational Resources Information Center

Freeman, Donald

2017-01-01

New conceptualizations of English are challenging traditional norms of what the language is, as well as how it is taught and by whom. These changes, coupled with the expansion of teaching English across the educational spectrum from younger grades to tertiary levels, present challenges to many national education systems. The role of teachers'…

Evolution and Ontogeny of Stress Response to Social Challenges in the Human Child

ERIC Educational Resources Information Center

Flinn, Mark V.

2006-01-01

The stress response systems of the human child are highly sensitive to social challenges. Because stress hormones can have negative developmental and health consequences, this presents an evolutionary paradox: Why would natural selection have favored mechanisms that elevate stress hormone levels in response to psychosocial stimuli? Two…

Roman Catholic Schooling in Ontario: Past Struggles, Present Challenges, Future Direction?

ERIC Educational Resources Information Center

Brennan, Terri-Lynn Kay

2011-01-01

Ontario Roman Catholic communities have established and maintained their own schools for over 200 years. Yet, their struggle for survival has not come without many challenges, setbacks, and criticisms. With the achievement of open-access at the secondary level and equal funding across the system, many question the legitimacy and worthiness of…

Supporting Medical Students to Do International Field Research: A Case Study

ERIC Educational Resources Information Center

Pearson, Stephen; Parr, Jennifer; Ullah, Zafar; Omar, Maye

2014-01-01

Field research can benefit medical students' learning through experiential engagement with research and personal exposure to foreign health systems. However, the off-campus nature of the activity raises challenges for teachers. This article presents a case study that illustrates the benefits and challenges of organising a field research project…

School-Wide Proactive Approaches to Working with Students with Challenging Behaviors.

ERIC Educational Resources Information Center

Bullock, Lyndal M., Ed.; Gable, Robert A., Ed.

This monograph presents highlights from a 2002 forum on school-wide approaches to working with students with challenging behaviors. The forum's focus was on ways to make systemic changes to create school environments that support the use of positive academic and behavioral interventions at the building and classroom levels. The following…

Challenges: The State Board of Community Colleges 1988 Master Plan.

ERIC Educational Resources Information Center

Florida State Board of Community Colleges, Tallahassee.

The Florida State Board of Community Colleges' 1988 Master Plan presents current trends, challenges, and issues affecting the system in order to guide both local and state institutional development and legislation. The first section of the plan reviews population trends, indicating that: (1) population growth will be the most influential trend…

The New Basic Agenda: Public Policy Directions for Student Success.

ERIC Educational Resources Information Center

California Community Colleges, Sacramento. Board of Governors.

Intended as a guide for policymakers in the California community colleges for the last half of the 1990s, this report describes four challenges facing the community college system and identifies major policy directions. Following an introduction, the following challenges are presented: (1) the delivery of high quality education in a manner that…

Dynamic Tensions: Early Reflections from MDRC's Evaluation of the Innovative Professional Development Challenge

ERIC Educational Resources Information Center

MDRC, 2015

2015-01-01

In the Innovative Professional Development (iPD) Challenge, the Bill & Melinda Gates Foundation has invested in helping school districts and networks redesign their instructional support systems to better support educators in increasing student success. This Issue Focus, the second in a series, presents early reflections from MDRC's evaluation…

Autonomy in Second Language Phonology: Choice vs. Limits

ERIC Educational Resources Information Center

Moyer, Alene

2017-01-01

Learning a new sound system poses challenges of a social, psychological, and cognitive nature, but the learner's decisions are key to ultimate attainment. This presentation focuses on two essential concepts: CHOICE, or how one wants to sound in the target language; and LIMITS, or various challenges to one's goals vis-a-vis accent. Qualitative and…

Current and Future Flight Operating Systems

NASA Technical Reports Server (NTRS)

Cudmore, Alan

2007-01-01

This viewgraph presentation reviews the current real time operating system (RTOS) type in use with current flight systems. A new RTOS model is described, i.e. the process model. Included is a review of the challenges of migrating from the classic RTOS to the Process Model type.

A case study : the Las Vegas Freeway and Arterial Management System : use of a systems manager contractor to procure ITS

DOT National Transportation Integrated Search

2000-03-01

Procurement of Intelligent Transportation System (ITS) projects using Federal-aid funds can present challenges that are not typically observed in traditional transportation projects. Many roadway improvement projects involve the two-step "Design-Bid-...

Ceramic Integration Technologies for Advanced Energy Systems: Critical Needs, Technical Challenges, and Opportunities

NASA Technical Reports Server (NTRS)

Singh, Mrityunjay

2010-01-01

Advanced ceramic integration technologies dramatically impact the energy landscape due to wide scale application of ceramics in all aspects of alternative energy production, storage, distribution, conservation, and efficiency. Examples include fuel cells, thermoelectrics, photovoltaics, gas turbine propulsion systems, distribution and transmission systems based on superconductors, nuclear power generation and waste disposal. Ceramic integration technologies play a key role in fabrication and manufacturing of large and complex shaped parts with multifunctional properties. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various needs, challenges, and opportunities in design, fabrication, and testing of integrated similar (ceramic ceramic) and dissimilar (ceramic metal) material www.nasa.gov 45 ceramic-ceramic-systems have been discussed. Experimental results for bonding and integration of SiC based Micro-Electro-Mechanical-Systems (MEMS) LDI fuel injector and advanced ceramics and composites for gas turbine applications are presented.

Constellation Program Design Challenges as Opportunities for Educational Outreach and Workforce Development for Senior Design Classes

NASA Technical Reports Server (NTRS)

Trevino, Robert C.

2009-01-01

The Texas Space Grant Consortium (TSGC) and the Exploration Systems Mission Directorate (ESMD) both have programs that present design challenges for university senior design classes that offer great opportunities for educational outreach and workforce development. These design challenges have been identified by NASA engineers and researchers as real design problems faced by the Constellation Program in its exploration missions and architecture. Student teams formed in their senior design class select and then work on a design challenge for one or two semesters. The senior design class follows the requirements set by their university, but it must also comply with the Accreditation Board for Engineering and Technology (ABET) in order to meet the class academic requirements. Based on a one year fellowship at a TSGC university under the NASA Administrator's Fellowship Program (NAFP) and several years of experience, results and metrics are presented on the NASA Design Challenge Program.

Constellation Program Design Challenges as Opportunities for Educational Outreach- Lessons Learned

NASA Technical Reports Server (NTRS)

Trevino, Robert C.

2010-01-01

The Texas Space Grant Consortium (TSGC) and the NASA Exploration Systems Mission Directorate (ESMD) Education Office both have programs that present design challenges for university senior design classes that offer great opportunities for educational outreach and workforce development. These design challenges have been identified by NASA engineers and scientists as actual design problems faced by the Constellation Program in its exploration missions and architecture. Student teams formed in their senior design class select and then work on a design challenge for one or two semesters. The senior design class follows the requirements set by their university, but it must also comply with the Accreditation Board for Engineering and Technology (ABET) in order to meet the class academic requirements. Based on a one year fellowship at a TSGC university under the NASA Administrator's Fellowship Program (NAFP) and several years of experience, lessons learned are presented on the NASA Design Challenge Program.

Psychosocial development in racially and ethnically diverse youth: conceptual and methodological challenges in the 21st century.

PubMed

Swanson, Dena Phillips; Spencer, Margaret Beale; Harpalani, Vinay; Dupree, Davido; Noll, Elizabeth; Ginzburg, Sofia; Seaton, Gregory

2003-01-01

As the US population becomes more diverse in the 21st century, researchers face many conceptual and methodological challenges in working with diverse populations. We discuss these issues for racially and ethnically diverse youth, using Spencer's phenomenological variant of ecological systems theory (PVEST) as a guiding framework. We present a brief historical background and discuss recurring conceptual flaws in research on diverse youth, presenting PVEST as a corrective to these flaws. We highlight the interaction of race, culture, socioeconomic status, and various contexts of development with identity formation and other salient developmental processes. Challenges in research design and interpretation of data are also covered with regard to both assessment of contexts and developmental processes. We draw upon examples from neighborhood assessments, ethnic identity development, and attachment research to illustrate conceptual and methodological challenges, and we discuss strategies to address these challenges. The policy implications of our analysis are also considered.

Challenges in the analysis of complex systems: introduction and overview

NASA Astrophysics Data System (ADS)

Hastings, Harold M.; Davidsen, Jörn; Leung, Henry

2017-12-01

One of the main challenges of modern physics is to provide a systematic understanding of systems far from equilibrium exhibiting emergent behavior. Prominent examples of such complex systems include, but are not limited to the cardiac electrical system, the brain, the power grid, social systems, material failure and earthquakes, and the climate system. Due to the technological advances over the last decade, the amount of observations and data available to characterize complex systems and their dynamics, as well as the capability to process that data, has increased substantially. The present issue discusses a cross section of the current research on complex systems, with a focus on novel experimental and data-driven approaches to complex systems that provide the necessary platform to model the behavior of such systems.

Rethinking Environmental Protection: Meeting the Challenges of a Changing World.

PubMed

Burke, Thomas A; Cascio, Wayne E; Costa, Daniel L; Deener, Kacee; Fontaine, Thomas D; Fulk, Florence A; Jackson, Laura E; Munns, Wayne R; Orme-Zavaleta, Jennifer; Slimak, Michael W; Zartarian, Valerie G

2017-03-01

From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today’s environmental problems are increasingly complex and new scientific approaches and tools are needed to achieve sustainable solutions to protect the environment and public health. In this article, we present examples of today’s environmental challenges and offer an integrated systems approach to address them. We provide a strategic framework and recommendations for advancing the application of science for protecting the environment and public health. We posit that addressing 21st century challenges requires transdisciplinary and systems approaches, new data sources, and stakeholder partnerships. To address these challenges, we outline a process driven by problem formulation with the following steps: a ) formulate the problem holistically, b ) gather and synthesize diverse information, c ) develop and assess options, and d ) implement sustainable solutions. This process will require new skills and education in systems science, with an emphasis on science translation. A systems-based approach can transcend media- and receptor-specific bounds, integrate diverse information, and recognize the inextricable link between ecology and human health.

Rethinking Environmental Protection: Meeting the Challenges of a Changing World

PubMed Central

Burke, Thomas A.; Cascio, Wayne E.; Costa, Daniel L.; Deener, Kacee; Fontaine, Thomas D.; Fulk, Florence A.; Jackson, Laura E.; Munns, Wayne R.; Orme-Zavaleta, Jennifer; Slimak, Michael W.; Zartarian, Valerie G.

2017-01-01

Summary: From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today’s environmental problems are increasingly complex and new scientific approaches and tools are needed to achieve sustainable solutions to protect the environment and public health. In this article, we present examples of today’s environmental challenges and offer an integrated systems approach to address them. We provide a strategic framework and recommendations for advancing the application of science for protecting the environment and public health. We posit that addressing 21st century challenges requires transdisciplinary and systems approaches, new data sources, and stakeholder partnerships. To address these challenges, we outline a process driven by problem formulation with the following steps: a) formulate the problem holistically, b) gather and synthesize diverse information, c) develop and assess options, and d) implement sustainable solutions. This process will require new skills and education in systems science, with an emphasis on science translation. A systems-based approach can transcend media- and receptor-specific bounds, integrate diverse information, and recognize the inextricable link between ecology and human health. PMID:28248180

Psychosocial health challenges of the elderly in Nigeria: a narrative review.

PubMed

Animasahun, Victor J; Chapman, Helena J

2017-06-01

Globally, national health systems are challenged to build successful aging models to prepare for biomedical, psychological and social changes. The integral component of psychosocial health in overall quality of life and well-being, however, is underscored and requires greater focus. Changing demographics in Nigeria, in addition to cultural considerations and absence of a social security system, present unique challenges to elderly. We aimed to review the literature that describes the current situation and challenges in psychosocial health status in the elderly in Nigeria and provide recommendations that promote health and well-being during the aging process. Four primary factors affect psychosocial health status of elderly Nigerians, namely: changes in family dynamics, increased demand for healthcare services, increased economic stress, and decreased functional independence. Like other developing countries, the Nigerian national system faces similar challenges in preparing a national framework that can maximize coverage to citizens in the midst of demographic changes in aging. By focusing on five target areas such as the educational system, health services, community-based initiatives, local or regional policies and national strategies, current framework in Nigeria can be modified to prepare for changing demographics in aging.

Chronic disease management and the home-care alternative in Ontario, Canada.

PubMed

Tsasis, Peter

2009-08-01

The pressure on our health-care system to deliver efficient, quality and cost-effective care is increasing. The debate on its sustainability is also expanding. These challenges can be managed with revisions to our health-care policy frameworks governing how and what public health-care services are delivered. Chronic disease management and home care can together ease many of the present and future pressures facing the health-care system. However, the current level of investment and the present policy are not effectively supporting movement in this direction. Updating the Canada Health Act to reflect the realities of our health-care system, and developing policies to support the areas of interdisciplinary teamwork and system integration are needed to facilitate chronic disease management and home care in Canada. This article lays out the challenges, highlights the impending issues and suggests a framework for moving forward.

Seal Technology for Hypersonic Vehicle and Propulsion: An Overview

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.

2008-01-01

Hypersonic vehicles and propulsion systems pose an extraordinary challenge for structures and materials. Airframes and engines require lightweight, high-temperature materials and structural configurations that can withstand the extreme environment of hypersonic flight. Some of the challenges posed include very high temperatures, heating of the whole vehicle, steady-state and transient localized heating from shock waves, high aerodynamic loads, high fluctuating pressure loads, potential for severe flutter, vibration, and acoustic loads and erosion. Correspondingly high temperature seals are required to meet these aggressive requirements. This presentation reviews relevant seal technology for both heritage (e.g. Space Shuttle, X-15, and X-38) vehicles and presents several seal case studies aimed at providing lessons learned for future hypersonic vehicle seal development. This presentation also reviews seal technology developed for the National Aerospace Plane propulsion systems and presents several seal case studies aimed at providing lessons learned for future hypersonic propulsion seal development.

Data Integration for Dynamic and Sustainable Systems Biology Resources: Challenges and Lessons Learned

PubMed Central

Gabbard, Joseph L.; Shukla, Maulik; Sobral, Bruno

2010-01-01

Systems biology and infectious disease (host-pathogen-environment) research and development is becoming increasingly dependent on integrating data from diverse and dynamic sources. Maintaining integrated resources over long periods of time presents distinct challenges. This paper describes experiences and lessons learned from integrating data in two five-year projects focused on pathosystems biology: the Pathosystems Resource Integration Center (PATRIC, http://patric.vbi.vt.edu/), with a goal of developing bioinformatics resources for the research and countermeasures development communities based on genomics data, and the Resource Center for Biodefense Proteomics Research (RCBPR, http://www.proteomicsresource.org/), with a goal of developing resources based on the experiment data such as microarray and proteomics data from diverse sources and technologies. Some challenges include integrating genomic sequence and experiment data, data synchronization, data quality control, and usability engineering. We present examples of a variety of data integration problems drawn from our experiences with PATRIC and RBPRC, as well as open research questions related to long term sustainability, and describe the next steps to meeting these challenges. Novel contributions of this work include (1) an approach for addressing discrepancies between experiment results and interpreted results and (2) expanding the range of data integration techniques to include usability engineering at the presentation level. PMID:20491070

Studies of thermal dissolution of RDX in TNT melt

NASA Astrophysics Data System (ADS)

Suvorova, N. A.; Hamilton, V. T.; Oschwald, D. M.; Balakirev, F. F.; Smilowitz, L. B.; Henson, B. F.

2017-01-01

The thermal response of energetic materials is studied due to its importance in issues of material safety and surety. Secondary high explosives which melt before they thermally decompose present challenging systems to model due to the addition of material flow. Composition B is a particularly challenging system due to its multiphase nature with a low melt component (TNT) and a high melt component (RDX). The dissolution of RDX crystals in molten TNT at the temperature below RDX melting point has been investigated using hot stage microscopy. In this paper, we present data on the dissolution rate of RDX crystals in molten TNT as a function of temperature above the TNT melt.

Mars Solar Power

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.; Kerslake, Thomas W.; Jenkins, Phillip P.; Scheiman, David A.

2004-01-01

NASA missions to Mars, both robotic and human, rely on solar arrays for the primary power system. Mars presents a number of challenges for solar power system operation, including a dusty atmosphere which modifies the spectrum and intensity of the incident solar illumination as a function of time of day, degradation of the array performance by dust deposition, and low temperature operation. The environmental challenges to Mars solar array operation will be discussed and test results of solar cell technology operating under Mars conditions will be presented, along with modeling of solar cell performance under Mars conditions. The design implications for advanced solar arrays for future Mars missions is discussed, and an example case, a Martian polar rover, are analyzed.

Supporting Greenhouse Gas Management Strategies with Observations and Analysis - Challenges and Opportunities

NASA Astrophysics Data System (ADS)

Butler, J. H.; Tarasova, O. A.

2014-12-01

Climate-change challenges facing society in the 21st century require an improved understanding of the global carbon-cycle and of the impacts and feedbacks of past, present, and future emissions of carbon-cycle gases. Global society faces a major challenge of reducing greenhouse gas emissions to virtually zero, most notably those of CO2, while at the same time facing variable and potentially overwhelming Earth System feedbacks. How it goes about this will depend upon the nature of impending international agreements, national laws, regional strategies, and social and economic forces. The challenge to those making observations to support, inform, or verify these reduction efforts, or to address potential Earth System feedbacks, lies in harmonizing a diverse array of observations and observing systems. Doing so is not trivial. Providing coherent, regional-scale information from these observations also requires improved modelling and ensemble reanalysis, but in the end such information must be relevant and reasonably certain. The challenge to us is to ensure a globally coherent observing and analysis system to supply the information that society will need to succeed. Policy-makers, scientists, government agencies, and businesses will need the best information available for decision-making and any observing and analysis system ultimately must be able to provide a coherent story over decades.

Social challenges when implementing information systems in everyday work in a nursing context.

PubMed

Nilsson, Lina; Eriksén, Sara; Borg, Christel

2014-09-01

Implementation of information systems in healthcare has become a lengthy process where healthcare staff (eg, nurses) are expected to put information into systems without getting the overall picture of the potential usefulness for their own work. The aim of this study was to explore social challenges when implementing information systems in everyday work in a nursing context. Moreover, this study aimed at putting perceived social challenges in a theoretical framework to address them more constructively when implementing information systems in healthcare. Influenced by institutional ethnography, the findings are based on interviews, observations, and written reflections. Power (changing the existing hierarchy, alienation), professional identity (calling on hold, expert becomes novice, changed routines), and encounter (ignorant introductions, preconceived notions) were categories (subcategories) presented in the findings. Social Cognitive Theory, Diffusion of Innovations, organizational culture, and dramaturgical analysis are proposed to set up a theoretical framework. If social challenges are not considered and addressed in the implementation process, it will be affected by nurses' solidarity to existing power structures and their own professional identity. Thus, implementation of information systems affects more aspects in the organization than might have been intended. These aspects need to be taken in to account in the implementation process.

Linear Temporal Logic (LTL) Based Monitoring of Smart Manufacturing Systems

PubMed Central

Heddy, Gerald; Huzaifa, Umer; Beling, Peter; Haimes, Yacov; Marvel, Jeremy; Weiss, Brian; LaViers, Amy

2017-01-01

The vision of Smart Manufacturing Systems (SMS) includes collaborative robots that can adapt to a range of scenarios. This vision requires a classification of multiple system behaviors, or sequences of movement, that can achieve the same high-level tasks. Likewise, this vision presents unique challenges regarding the management of environmental variables in concert with discrete, logic-based programming. Overcoming these challenges requires targeted performance and health monitoring of both the logical controller and the physical components of the robotic system. Prognostics and health management (PHM) defines a field of techniques and methods that enable condition-monitoring, diagnostics, and prognostics of physical elements, functional processes, overall systems, etc. PHM is warranted in this effort given that the controller is vulnerable to program changes, which propagate in unexpected ways, logical runtime exceptions, sensor failure, and even bit rot. The physical component’s health is affected by the wear and tear experienced by machines constantly in motion. The controller’s source of faults is inherently discrete, while the latter occurs in a manner that builds up continuously over time. Such a disconnect poses unique challenges for PHM. This paper presents a robotic monitoring system that captures and resolves this disconnect. This effort leverages supervisory robotic control and model checking with linear temporal logic (LTL), presenting them as a novel monitoring system for PHM. This methodology has been demonstrated in a MATLAB-based simulator for an industry inspired use-case in the context of PHM. Future work will use the methodology to develop adaptive, intelligent control strategies to evenly distribute wear on the joints of the robotic arms, maximizing the life of the system. PMID:28730154

Wind Power: A Renewable Energy Source for Mars Transit Vehicle

NASA Technical Reports Server (NTRS)

Flynn, Michael; Kohout, Lisa; Kliss, Mark (Technical Monitor)

1998-01-01

The Martian environment presents significant design challenges for the development of power generation systems. Nuclear-based systems may not be available due to political and safety concerns. The output of photovoltaics are limited by a solar intensity of 580 W/sqm as compared to 1353 W/sqm on Earth. The presence of dust particles in the Mars atmosphere will further reduce the photovoltaic output. Also, energy storage for a 12-hour night period must be provided. In this challenging environment, wind power generation capabilities may provide a viable option as a Martian power generation system. This paper provides an analysis of the feasibility of such a system.

Impacts of Short-Term Solar Power Forecasts in System Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ibanez, Eduardo; Krad, Ibrahim; Hodge, Bri-Mathias

2016-05-05

Solar generation is experiencing an exponential growth in power systems worldwide and, along with wind power, is posing new challenges to power system operations. Those challenges are characterized by an increase of system variability and uncertainty across many time scales: from days, down to hours, minutes, and seconds. Much of the research in the area has focused on the effect of solar forecasting across hours or days. This paper presents a methodology to capture the effect of short-term forecasting strategies and analyzes the economic and reliability implications of utilizing a simple, yet effective forecasting method for solar PV in intra-daymore » operations.« less

On the X-34 FASTRAC-Memorandums of Misunderstanding

NASA Technical Reports Server (NTRS)

Hawkins, Lakiesha V.; Turner, Jim E.

2015-01-01

Engineers at MSFC designed, developed, and tested propulsion systems that helped launch Saturn I, IB, and V boosters for the Apollo missions. After the Apollo program, Marshall was responsible for the design and development of the propulsion elements for the Shuttle launch vehicle, including the solid rocket boosters, external tank and main engines. Each of these systems offered new propulsion technological challenges that pushed engineers and administrators beyond Saturn. The technical challenges presented by the development of each of these propulsion systems helped to establish and sustain a culture of engineering conservatism and was often accompanied by a deep level of penetration into contractors that worked on these systems.

Multi -omics and metabolic modelling pipelines: challenges and tools for systems microbiology.

PubMed

Fondi, Marco; Liò, Pietro

2015-02-01

Integrated -omics approaches are quickly spreading across microbiology research labs, leading to (i) the possibility of detecting previously hidden features of microbial cells like multi-scale spatial organization and (ii) tracing molecular components across multiple cellular functional states. This promises to reduce the knowledge gap between genotype and phenotype and poses new challenges for computational microbiologists. We underline how the capability to unravel the complexity of microbial life will strongly depend on the integration of the huge and diverse amount of information that can be derived today from -omics experiments. In this work, we present opportunities and challenges of multi -omics data integration in current systems biology pipelines. We here discuss which layers of biological information are important for biotechnological and clinical purposes, with a special focus on bacterial metabolism and modelling procedures. A general review of the most recent computational tools for performing large-scale datasets integration is also presented, together with a possible framework to guide the design of systems biology experiments by microbiologists. Copyright © 2015. Published by Elsevier GmbH.

Grand challenges in mass storage: A system integrator's perspective

NASA Technical Reports Server (NTRS)

Mintz, Dan; Lee, Richard

1993-01-01

The grand challenges are the following: to develop more innovation in approach; to expand the I/O barrier; to achieve increased volumetric efficiency and incremental cost improvements; to reinforce the 'weakest link' software; to implement improved architectures; and to minimize the impact of self-destructing technologies. Mass storage is defined as any type of storage system exceeding 100 GBytes in total size, under the control of a centralized file management scheme. The topics covered are presented in viewgraph form.

Challenges facing the distribution of an artificial-intelligence-based system for nursing.

PubMed

Evans, S

1985-04-01

The marketing and successful distribution of artificial-intelligence-based decision-support systems for nursing face special barriers and challenges. Issues that must be confronted arise particularly from the present culture of the nursing profession as well as the typical organizational structures in which nurses predominantly work. Generalizations in the literature based on the limited experience of physician-oriented artificial intelligence applications (predominantly in diagnosis and pharmacologic treatment) must be modified for applicability to other health professions.

Human Space Flight Challenges: Get a Leg Up

NASA Technical Reports Server (NTRS)

Lloyd, Charles W.

2008-01-01

This viewgraph presentation reviews some of the challenges that spaceflight imposes on the Human system. It describes four of the signs and symptoms of fluid shift in the astronaut when they fly in low earth orbit. It describes how the leg muscles influence blood flow It also outlines the four phases of "fluid shift" and where the majority of the central volume of blood is located in the body And it reviews other changes to the body systems as a result of Fluid Shift

Building a Workforce for Future Health Systems: Reflections from Health Policy and Systems Research.

PubMed

Javadi, Dena; Tran, Nhan; Ghaffar, Abdul

2018-05-24

The era of the Sustainable Development Goals calls for multidisciplinary research and intersectoral approaches to addressing health challenges. This presents a unique opportunity for multidisciplinary fields concerned with complex systems. Those working in system-oriented fields such as health policy and systems research (HPSR) and health services research must be forward-thinking in optimizing their collective ability to address these global challenges. The objective of this commentary was to share reflections on challenges and strategies in managing the HPSR workforce in order to stimulate dialogue and cross-learning across similar fields. The following strategies are discussed here: definitional clarity of expected competencies and coordination across HPS researchers, national investment in HPSR, institutional capacity for coproduction of knowledge across different types of actors, and participatory leadership. Creative approaches in training, financing, developing, and leading the diverse workforce required to strengthen health systems can pave the way for its full-time and part-time members to work together. © Health Research and Educational Trust.

Infrared stereo calibration for unmanned ground vehicle navigation

NASA Astrophysics Data System (ADS)

Harguess, Josh; Strange, Shawn

2014-06-01

The problem of calibrating two color cameras as a stereo pair has been heavily researched and many off-the-shelf software packages, such as Robot Operating System and OpenCV, include calibration routines that work in most cases. However, the problem of calibrating two infrared (IR) cameras for the purposes of sensor fusion and point could generation is relatively new and many challenges exist. We present a comparison of color camera and IR camera stereo calibration using data from an unmanned ground vehicle. There are two main challenges in IR stereo calibration; the calibration board (material, design, etc.) and the accuracy of calibration pattern detection. We present our analysis of these challenges along with our IR stereo calibration methodology. Finally, we present our results both visually and analytically with computed reprojection errors.

Design of Electrical Systems for Rocket Propulsion Test Facilities at the John C. Stennis Space Center

NASA Technical Reports Server (NTRS)

Hughes, Mark S.; Davis, Dawn M.; Bakker, Henry J.; Jensen, Scott L.

2007-01-01

This viewgraph presentation reviews the design of the electrical systems that are required for the testing of rockets at the Rocket Propulsion Facility at NASA Stennis Space Center (NASA SSC). NASA/SSC s Mission in Rocket Propulsion Testing Is to Acquire Test Performance Data for Verification, Validation and Qualification of Propulsion Systems Hardware. These must be accurate reliable comprehensive and timely. Data acquisition in a rocket propulsion test environment is challenging: severe temporal transient dynamic environments, large thermal gradients, vacuum to 15 ksi pressure regimes SSC has developed and employs DAS, control systems and control systems and robust instrumentation that effectively satisfies these challenges.

Renewable Electricity Futures (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mai, T.

2012-08-01

This presentation summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. It was presented in a Power Systems Engineering Research Center webinar on September 4, 2012.

Cleaning Insertions and Collimation Challenges

NASA Astrophysics Data System (ADS)

Redaelli, S.; Appleby, R. B.; Bertarelli, A.; Bruce, R.; Jowett, J. M.; Lechner, A.; Losito, R.

High-performance collimation systems are essential for operating efficiently modern hadron machine with large beam intensities. In particular, at the LHC the collimation system ensures a clean disposal of beam halos in the superconducting environment. The challenges of the HL-LHC study pose various demanding requests for beam collimation. In this paper we review the present collimation system and its performance during the LHC Run 1 in 2010-2013. Various collimation solutions under study to address the HL-LHC requirements are then reviewed, identifying the main upgrade baseline and pointing out advanced collimation concept for further enhancement of the performance.

Training for laparoscopic pancreaticoduodenectomy.

PubMed

Kuroki, Tamotsu; Fujioka, Hikaru

2018-05-10

In recent years, laparoscopic procedures have developed rapidly, and the reports of laparoscopic pancreatic resection including laparoscopic pancreaticoduodenectomy (LPD) have increased in number. Although LPD is a complex procedure with high mortality, the training system for LPD remains unestablished. Ensuring patient safety is extremely important, even in challenging surgeries such a LPD. At present, several tools have been developed for surgical education to ensure patient safety preoperatively, such as video learning, virtual reality simulators, and cadaver training. Although LPD is reported as a safe and feasible choice, LPD is still a challenging operation. An LPD training system should be established with a board-certified system.

Systems engineering in a joint program environment: the joint helmet-mounted cueing system

NASA Astrophysics Data System (ADS)

Wilkins, Donald F.

1999-07-01

The Joint Helmet Mounted Cueing System (JHMCS) is a design program involving two airframe companies (Boeing and Lockheed Martin), two services (USAF and USN) and four aircraft platforms: the F-22, the F-16, the F/A-18 and the F-15. Developing equipment requirements for the combined operational and environmental needs of these diverse communities is a significant challenge. In addition, the team is geographically dispersed which presented challenges in communication and coordination. This paper details the lessons learned in producing a cost-effective design within a short development schedule and makes recommendations for future development programs.

Use and Adoption of an Assisted Cognition System to Support Therapies for People with Dementia.

PubMed

Navarro, René F; Rodríguez, Marcela D; Favela, Jesús

2016-01-01

The cognitive deficits in persons with dementia (PwD) can produce significant functional impairment from early stages. Although memory decline is most prominent, impairments in attention, orientation, language, reasoning, and executive functioning are also common. Dementia is also characterized by changes in personality and behavioral functioning that can be very challenging for caregivers and patients. This paper presents results on the use and adoption of an assisted cognition system to support occupational therapy to address psychological and behavioral symptoms of dementia. During 16 weeks, we conducted an in situ evaluation with two caregiver-PwD dyads to assess the adoption and effectiveness of the system to ameliorate challenging behaviors and reducing caregiver burden. Evaluation results indicate that intervention personalization and a touch-based interface encouraged the adoption of the system, helping reduce challenging behaviors in PwD and caregiver burden.

Pipelining in a changing competitive environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, E.G.; Wishart, D.M.

1996-12-31

The changing competitive environment for the pipeline industry presents a broad spectrum of new challenges and opportunities: international cooperation; globalization of opportunities, organizations and competition; and integrated systems approach to system configuration, financing, contracting strategy, materials sourcing, and operations; cutting edge and emerging technologies; adherence to high standards of environmental protection; an emphasis on safety; innovative approaches to project financing; and advances in technology and programs to maintain the long term, cost effective integrity of operating pipeline systems. These challenges and opportunities are partially a result of the increasingly competitive nature of pipeline development and the public`s intolerance to incidentsmore » of pipeline failure. A creative systems approach to these challenges is often the key to the project moving ahead. This usually encompasses collaboration among users of the pipeline, pipeline owners and operators, international engineering and construction companies, equipment and materials suppliers, in-country engineers and constructors, international lending agencies and financial institutions.« less

Optimal Design of MPPT Controllers for Grid Connected Photovoltaic Array System

NASA Astrophysics Data System (ADS)

Ebrahim, M. A.; AbdelHadi, H. A.; Mahmoud, H. M.; Saied, E. M.; Salama, M. M.

2016-10-01

Integrating photovoltaic (PV) plants into electric power system exhibits challenges to power system dynamic performance. These challenges stem primarily from the natural characteristics of PV plants, which differ in some respects from the conventional plants. The most significant challenge is how to extract and regulate the maximum power from the sun. This paper presents the optimal design for the most commonly used Maximum Power Point Tracking (MPPT) techniques based on Proportional Integral tuned by Particle Swarm Optimization (PI-PSO). These suggested techniques are, (1) the incremental conductance, (2) perturb and observe, (3) fractional short circuit current and (4) fractional open circuit voltage techniques. This research work provides a comprehensive comparative study with the energy availability ratio from photovoltaic panels. The simulation results proved that the proposed controllers have an impressive tracking response. The system dynamic performance improved greatly using the proposed controllers.

Student Information Systems--Implementation Challenges and the Road Ahead

ERIC Educational Resources Information Center

Mukerjee, Sheila

2012-01-01

This paper presents a practitioner's view on student system implementations in the Australian university sector. A student information system is a core system of any university and integral to its operations and services to students. These systems are constantly on the list of major projects and at any point in time, a university is either…

Communicating Research to Small Drinking Water Systems: Dissemination by Researchers

EPA Science Inventory

This talk discusses the challenges of disseminating research relevant to small systems. The presentation discusses efforts by the U.S. EPA’s Office of Research and Development to effectively communicating drinking water information. In particular, communication approaches ...

Integrating High Levels of Variable Renewable Energy into Electric Power Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kroposki, Benjamin D.

As more variable renewable energy is integrated into electric power systems, there are a range of challenges and solutions to accommodating very high penetration levels. This presentation highlights some of the recent research in this area.

Intelligent rover decision-making in response to exogenous events

NASA Technical Reports Server (NTRS)

Chouinard, C.; Estlin, T.; Gaines, D.; Fisher, F.

2005-01-01

This paper presents an introduction to the CLEAR system which performs rover command generation and re-planning, the challenges faced maintaining domain specific information in an uncertain environment, and the successes demonstrated with several methods of system testing.

Biomorphic Systems and Biomorphic Missions

NASA Technical Reports Server (NTRS)

Thakoor, Sarita

2000-01-01

A viewgraph presentation (with an explanation for each slide) gives an overview of biomorphic systems and missions. Biomorphic explorers are classified, and the challenge to obtain a biomorphic robot is described. Characteristics of biomorphic explorers are described, and biomorphic missions are discussed.

Evaluation of 3M(TM) Scotchlite linear delineation system : final report.

DOT National Transportation Integrated Search

2004-09-01

Major construction projects present many hazards for drivers to negotiate. Detours, lane shifts and confusing curves : present unique challenges to all drivers. At night, the difficulties in negotiating these obstacles are amplified due to : reduced ...

Artificial intelligence in public health prevention of legionelosis in drinking water systems.

PubMed

Sinčak, Peter; Ondo, Jaroslav; Kaposztasova, Daniela; Virčikova, Maria; Vranayova, Zuzana; Sabol, Jakub

2014-08-21

Good quality water supplies and safe sanitation in urban areas are a big challenge for governments throughout the world. Providing adequate water quality is a basic requirement for our lives. The colony forming units of the bacterium Legionella pneumophila in potable water represent a big problem which cannot be overlooked for health protection reasons. We analysed several methods to program a virtual hot water tank with AI (artificial intelligence) tools including neuro-fuzzy systems as a precaution against legionelosis. The main goal of this paper is to present research which simulates the temperature profile in the water tank. This research presents a tool for a water management system to simulate conditions which are able to prevent legionelosis outbreaks in a water system. The challenge is to create a virtual water tank simulator including the water environment which can simulate a situation which is common in building water distribution systems. The key feature of the presented system is its adaptation to any hot water tank. While respecting the basic parameters of hot water, a water supplier and building maintainer are required to ensure the predefined quality and water temperature at each sampling site and avoid the growth of Legionella. The presented system is one small contribution how to overcome a situation when legionelosis could find good conditions to spread and jeopardize human lives.

Artificial Intelligence in Public Health Prevention of Legionelosis in Drinking Water Systems

PubMed Central

Sinčak, Peter; Ondo, Jaroslav; Kaposztasova, Daniela; Virčikova, Maria; Vranayova, Zuzana; Sabol, Jakub

2014-01-01

Good quality water supplies and safe sanitation in urban areas are a big challenge for governments throughout the world. Providing adequate water quality is a basic requirement for our lives. The colony forming units of the bacterium Legionella pneumophila in potable water represent a big problem which cannot be overlooked for health protection reasons. We analysed several methods to program a virtual hot water tank with AI (artificial intelligence) tools including neuro-fuzzy systems as a precaution against legionelosis. The main goal of this paper is to present research which simulates the temperature profile in the water tank. This research presents a tool for a water management system to simulate conditions which are able to prevent legionelosis outbreaks in a water system. The challenge is to create a virtual water tank simulator including the water environment which can simulate a situation which is common in building water distribution systems. The key feature of the presented system is its adaptation to any hot water tank. While respecting the basic parameters of hot water, a water supplier and building maintainer are required to ensure the predefined quality and water temperature at each sampling site and avoid the growth of Legionella. The presented system is one small contribution how to overcome a situation when legionelosis could find good conditions to spread and jeopardize human lives. PMID:25153475

The challenge of a data storage hierarchy

NASA Technical Reports Server (NTRS)

Ruderman, Michael

1992-01-01

A discussion of Mesa Archival Systems' data archiving system is presented. This data archiving system is strictly a software system that is implemented on a mainframe and manages the data into permanent file storage. Emphasis is placed on the fact that any kind of client system on the network can be connected through the Unix interface of the data archiving system.

Music Students' Perceptions of Experiential Learning at the Moot Audition

ERIC Educational Resources Information Center

Mitchell, Helen F.

2018-01-01

The music industry is built on a system of expert evaluation focused on sound, but the foundations are challenged by recent research, which suggests that sight trumps sound. This presents a challenge to music educators, who train the next generation of expert performers and listeners. The aim of this study is to investigate students' perceptions…

Early Childhood Education in Europe. Achievements: Challenges and Possibilities

ERIC Educational Resources Information Center

Urban, Mathias

2009-01-01

This document is the report of a study commissioned by Education International. The aim of this study is to present key characteristics of ECE systems, to highlight strengths and successful approaches and to identify major challenges and areas where urgent action is needed. To achieve this aim, the report comprises two main sections. The first…

Beyond knowledge capture: creating useful work-centric systems

NASA Technical Reports Server (NTRS)

Cooper, L. P.; Majchrzak, A.

2001-01-01

Once you have successfully captured knowledge, the challenge then becomes one of creating an affective way to use that knowledge. Two high knowledge content systems developed at the Jet Propulsion Laboratory are presented as examples of work-centric systems, where the primary value to the user is in the content.

Data systems and computer science space data systems: Onboard memory and storage

NASA Technical Reports Server (NTRS)

Shull, Tom

1991-01-01

The topics are presented in viewgraph form and include the following: technical objectives; technology challenges; state-of-the-art assessment; mass storage comparison; SODR drive and system concepts; program description; vertical Bloch line (VBL) device concept; relationship to external programs; and backup charts for memory and storage.

The Competitive Struggle.

ERIC Educational Resources Information Center

Barry, Jeff; Bilal, Dania; Penniman, W. David

1998-01-01

Presents results of a survey of 30 library systems vendors to examine how successfully they met the key challenges of 1997: integration, testing, and marketing a new generation of systems. Character-based systems, the Dublin Core, Java, and the Z39.50 standard are discussed. Profiles describing sales and product developments for each of the…

SIMULATION OF SULFATE AEROSOL IN EAST ASIA USING MODELS-3/CMAQ WITH RAMS METEOROLOGICAL DATA

EPA Science Inventory

The present study attempts to address a few challenges in utilizing the flexibility of the Models-3 Community Multiscale Air Quality (CMAQ) modeling system. We apply the CMAQ system with the meteorological data provided by the Regional Atmospheric Modeling System (RAMS) and to a...

Overview of NASA's Next Generation Air Transportation System (NextGen) Research

NASA Technical Reports Server (NTRS)

Swenson, Harry N.

2009-01-01

This slide presentation is an overview of the research for the Next Generation Air Transportation System (NextGen). Included is a review of the current air transportation system and the challenges of air transportation research. Also included is a review of the current research highlights and significant accomplishments.

Integrating social science into empirical models of coupled human and natural systems

Treesearch

Jeffrey D. Kline; Eric M. White; A Paige Fischer; Michelle M. Steen-Adams; Susan Charnley; Christine S. Olsen; Thomas A. Spies; John D. Bailey

2017-01-01

Coupled human and natural systems (CHANS) research highlights reciprocal interactions (or feedbacks) between biophysical and socioeconomic variables to explain system dynamics and resilience. Empirical models often are used to test hypotheses and apply theory that represent human behavior. Parameterizing reciprocal interactions presents two challenges for social...

Present challenges in hadrontherapy techniques

NASA Astrophysics Data System (ADS)

Amaldi, U.; Braccini, S.

2011-07-01

Hadrontherapy is a high-precision technique in cancer radiation therapy, which allows obtaining a superior conformal treatment with respect to photons used in conventional radiation therapy. To reach this ambitious goal without reducing the patient throughput needed in a hospital-based environment, the physical and radiobiological properties of charged hadrons, protons and carbon ions in particular, have to be exploited at best, making use of the most modern technologies issued from research in nuclear and particle physics. In the present days, we are assisting to a continuous technological challenge, leading to the conception and to the development of innovative methods and instruments. In this paper, the most relevant challenges in dose delivery systems, gantries, imaging, quality assurance and particle accelerators are reviewed.

CPMIP: measurements of real computational performance of Earth system models in CMIP6

NASA Astrophysics Data System (ADS)

Balaji, Venkatramani; Maisonnave, Eric; Zadeh, Niki; Lawrence, Bryan N.; Biercamp, Joachim; Fladrich, Uwe; Aloisio, Giovanni; Benson, Rusty; Caubel, Arnaud; Durachta, Jeffrey; Foujols, Marie-Alice; Lister, Grenville; Mocavero, Silvia; Underwood, Seth; Wright, Garrett

2017-01-01

A climate model represents a multitude of processes on a variety of timescales and space scales: a canonical example of multi-physics multi-scale modeling. The underlying climate system is physically characterized by sensitive dependence on initial conditions, and natural stochastic variability, so very long integrations are needed to extract signals of climate change. Algorithms generally possess weak scaling and can be I/O and/or memory-bound. Such weak-scaling, I/O, and memory-bound multi-physics codes present particular challenges to computational performance. Traditional metrics of computational efficiency such as performance counters and scaling curves do not tell us enough about real sustained performance from climate models on different machines. They also do not provide a satisfactory basis for comparative information across models. codes present particular challenges to computational performance. We introduce a set of metrics that can be used for the study of computational performance of climate (and Earth system) models. These measures do not require specialized software or specific hardware counters, and should be accessible to anyone. They are independent of platform and underlying parallel programming models. We show how these metrics can be used to measure actually attained performance of Earth system models on different machines, and identify the most fruitful areas of research and development for performance engineering. codes present particular challenges to computational performance. We present results for these measures for a diverse suite of models from several modeling centers, and propose to use these measures as a basis for a CPMIP, a computational performance model intercomparison project (MIP).

Large system change challenges: addressing complex critical issues in linked physical and social domains

NASA Astrophysics Data System (ADS)

Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna

2015-04-01

Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways, while others are undeniably and unavoidably deterministic.

Manned spacecraft electrical power systems

NASA Technical Reports Server (NTRS)

Simon, William E.; Nored, Donald L.

1987-01-01

A brief history of the development of electrical power systems from the earliest manned space flights illustrates a natural trend toward a growth of electrical power requirements and operational lifetimes with each succeeding space program. A review of the design philosophy and development experience associated with the Space Shuttle Orbiter electrical power system is presented, beginning with the state of technology at the conclusion of the Apollo Program. A discussion of prototype, verification, and qualification hardware is included, and several design improvements following the first Orbiter flight are described. The problems encountered, the scientific and engineering approaches used to meet the technological challenges, and the results obtained are stressed. Major technology barriers and their solutions are discussed, and a brief Orbiter flight experience summary of early Space Shuttle missions is included. A description of projected Space Station power requirements and candidate system concepts which could satisfy these anticipated needs is presented. Significant challenges different from Space Shuttle, innovative concepts and ideas, and station growth considerations are discussed. The Phase B Advanced Development hardware program is summarized and a status of Phase B preliminary tradeoff studies is presented.

Analysis and Perspective from the Complex Aerospace Systems Exchange (CASE) 2013

NASA Technical Reports Server (NTRS)

Jones, Kennie H.; Parker, Peter A.; Detweiler, Kurt N.; McGowan, Anna-Maria R.; Dress, David A.; Kimmel, William M.

2014-01-01

NASA Langley Research Center embedded four rapporteurs at the Complex Aerospace Systems Exchange (CASE) held in August 2013 with the objective to capture the essence of the conference presentations and discussions. CASE was established to provide a discussion forum among chief engineers, program managers, and systems engineers on challenges in the engineering of complex aerospace systems. The meeting consists of invited presentations and panels from industry, academia, and government followed by discussions among attendees. This report presents the major and reoccurring themes captured throughout the meeting and provides analysis and insights to further the CASE mission.

Ceramic Integration Technologies for Aerospace and Energy Systems: Technical Challenges and Opportunities

NASA Technical Reports Server (NTRS)

Singh, Mrityunjay

2007-01-01

Ceramic integration technology has been recognized as an enabling technology for the implementation of advanced ceramic systems in a number of high-temperature applications in aerospace, power generation, nuclear, chemical, and electronic industries. Various ceramic integration technologies (joining, brazing, attachments, repair, etc.) play a role in fabrication and manufacturing of large and complex shaped parts of various functionalities. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various challenges and opportunities in design, fabrication, and testing of integrated similar (ceramic-ceramic) and dissimilar (ceramic-metal) material systems will be discussed. Experimental results for bonding and integration of SiC based LDI fuel injector, high conductivity C/C composite based heat rejection system, solid oxide fuel cells system, ultra high temperature ceramics for leading edges, and ceramic composites for thermostructural applications will be presented. Potential opportunities and need for the development of innovative design philosophies, approaches, and integrated system testing under simulated application conditions will also be discussed.

Moving research tools into practice: the successes and challenges in promoting uptake of classification tools.

PubMed

Cunningham, Barbara Jane; Hidecker, Mary Jo Cooley; Thomas-Stonell, Nancy; Rosenbaum, Peter

2018-05-01

In this paper, we present our experiences - both successes and challenges - in implementing evidence-based classification tools into clinical practice. We also make recommendations for others wanting to promote the uptake and application of new research-based assessment tools. We first describe classification systems and the benefits of using them in both research and practice. We then present a theoretical framework from Implementation Science to report strategies we have used to implement two research-based classification tools into practice. We also illustrate some of the challenges we have encountered by reporting results from an online survey investigating 58 Speech-language Pathologists' knowledge and use of the Communication Function Classification System (CFCS), a new tool to classify children's functional communication skills. We offer recommendations for researchers wanting to promote the uptake of new tools in clinical practice. Specifically, we identify structural, organizational, innovation, practitioner, and patient-related factors that we recommend researchers address in the design of implementation interventions. Roles and responsibilities of both researchers and clinicians in making implementations science a success are presented. Implications for rehabilitation Promoting uptake of new and evidence-based tools into clinical practice is challenging. Implementation science can help researchers to close the knowledge-to-practice gap. Using concrete examples, we discuss our experiences in implementing evidence-based classification tools into practice within a theoretical framework. Recommendations are provided for researchers wanting to implement new tools in clinical practice. Implications for researchers and clinicians are presented.

Systems metabolic engineering of microorganisms to achieve large-scale production of flavonoid scaffolds.

PubMed

Wu, Junjun; Du, Guocheng; Zhou, Jingwen; Chen, Jian

2014-10-20

Flavonoids possess pharmaceutical potential due to their health-promoting activities. The complex structures of these products make extraction from plants difficult, and chemical synthesis is limited because of the use of many toxic solvents. Microbial production offers an alternate way to produce these compounds on an industrial scale in a more economical and environment-friendly manner. However, at present microbial production has been achieved only on a laboratory scale and improvements and scale-up of these processes remain challenging. Naringenin and pinocembrin, which are flavonoid scaffolds and precursors for most of the flavonoids, are the model molecules that are key to solving the current issues restricting industrial production of these chemicals. The emergence of systems metabolic engineering, which combines systems biology with synthetic biology and evolutionary engineering at the systems level, offers new perspectives on strain and process optimization. In this review, current challenges in large-scale fermentation processes involving flavonoid scaffolds and the strategies and tools of systems metabolic engineering used to overcome these challenges are summarized. This will offer insights into overcoming the limitations and challenges of large-scale microbial production of these important pharmaceutical compounds. Copyright © 2014 Elsevier B.V. All rights reserved.

Oil-Free Shaft Support System Rotordynamics: Past, Present, and Future Challenges and Opportunities

NASA Technical Reports Server (NTRS)

DellaCorte, Christopher

2011-01-01

Recent breakthroughs in Oil-Free technologies have enabled new high-speed rotor systems and turbomachinery. Such technologies can include compliant-surface gas bearings, magnetic bearings, and advanced solid lubricants and tribo-materials. This presentation briefly reviews critical technology developments and the current state-of-the-art, emerging Oil-Free rotor systems and discusses obstacles preventing more widespread use. Key examples of "best practices" for deploying Oil-Free technologies will be presented and remaining major technical questions surrounding Oil-Free technologies will be brought forward.

Healthcare-associated infections: challenges to public health in Brazil

PubMed Central

Padoveze, Maria Clara; Fortaleza, Carlos Magno Castelo Branco

2014-01-01

This study presents a critical evaluation of the scientific literature related to this subject, aiming to assess the policies and administrative issues regarding the prevention and magnitude of healthcare-associated infections and discuss the challenges for their prevention in Brazil. The topics discussed included historical and administrative issues, challenges imposed by the characteristics of the healthcare system and the territorial dimension, laboratorial support limitations, costs, institutional culture, professional qualification, and patient engagement. It is urgent to hold a nationwide discussion among government representatives, institutions, and healthcare workers and users to overcome these challenges. PMID:26039403

Introduction to State Estimation of High-Rate System Dynamics.

PubMed

Hong, Jonathan; Laflamme, Simon; Dodson, Jacob; Joyce, Bryan

2018-01-13

Engineering systems experiencing high-rate dynamic events, including airbags, debris detection, and active blast protection systems, could benefit from real-time observability for enhanced performance. However, the task of high-rate state estimation is challenging, in particular for real-time applications where the rate of the observer's convergence needs to be in the microsecond range. This paper identifies the challenges of state estimation of high-rate systems and discusses the fundamental characteristics of high-rate systems. A survey of applications and methods for estimators that have the potential to produce accurate estimations for a complex system experiencing highly dynamic events is presented. It is argued that adaptive observers are important to this research. In particular, adaptive data-driven observers are advantageous due to their adaptability and lack of dependence on the system model.

High Voltage Hybrid Electric Propulsion - Multilayered Functional Insulation System (MFIS) NASA-GRC

NASA Technical Reports Server (NTRS)

Lizcano, M.

2017-01-01

High power transmission cables pose a key challenge in future Hybrid Electric Propulsion Aircraft. The challenge arises in developing safe transmission lines that can withstand the unique environment found in aircraft while providing megawatts of power. High voltage AC, variable frequency cables do not currently exist and present particular electrical insulation challenges since electrical arcing and high heating are more prevalent at higher voltages and frequencies. Identifying and developing materials that maintain their dielectric properties at high voltage and frequencies is crucial.

Helium refrigeration systems for super-conducting accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ganni, V.

Many of the present day accelerators are based on superconducting technology which requires 4.5-K or 2-K helium refrigeration systems. These systems utilize superconducting radio frequency (SRF) cavities and/or superconducting magnets which are packaged into vacuum vessels known as cryo-modules (CM’s). Many of the present day accelerators are optimized to operate primarily at around 2-K, requiring specialized helium refrigeration systems which are cost intensive to produce and to operate. Some of the cryogenic refrigeration system design considerations for these challenging applications are discussed.

Enhanced optical design by distortion control

NASA Astrophysics Data System (ADS)

Thibault, Simon; Gauvin, Jonny; Doucet, Michel; Wang, Min

2005-09-01

The control of optical distortion is useful for the design of a variety of optical system. The most popular is the F-theta lens used in laser scanning system to produce a constant scan velocity across the image plane. Many authors have designed during the last 20 years distortion control corrector. Today, many challenging digital imaging system can use distortion the enhanced their imaging capability. A well know example is a reversed telephoto type, if the barrel distortion is increased instead of being corrected; the result is a so-called Fish-eye lens. However, if we control the barrel distortion instead of only increasing it, the resulting system can have enhanced imaging capability. This paper will present some lens design and real system examples that clearly demonstrate how the distortion control can improve the system performances such as resolution. We present innovative optical system which increases the resolution in the field of view of interest to meet the needs of specific applications. One critical issue when we designed using distortion is the optimization management. Like most challenging lens design, the automatic optimization is less reliable. Proper management keeps the lens design within the correct range, which is critical for optimal performance (size, cost, manufacturability). Many lens design presented tailor a custom merit function and approach.

NASA GRC MBSE Implementation Status

NASA Technical Reports Server (NTRS)

Parrott, Edith; Trase, Katie; Green, Randi; Varga, Denise; Powell, Joe

2016-01-01

This presentation gives a brief overview on GRCs Model Based System Engineering (MBSE) implementation status. This overview covers: history, project usage and implementation, challenges and future work.

Safe and Secure Virtualization: Answers for IMA next Generation and Beyond

NASA Astrophysics Data System (ADS)

Almeida, Jose; Vatrinet, Francis

2010-08-01

This paper presents some of the challenges the aerospace industry is facing for the future and explains why and how a safe and secured virtualization technology can help solving these challenges Efforts around the next generation of IMA have already started, like the European FP7 funded project SCARLETT or the IDEE5 project and many avionics players and working groupware focused on how the new technologies like SMP capabilities introduced in latest CPU architectures, can help increasing system performances in future avionics system. We present PikeOS, a separation micro-kernel, which applies the state-of-the-art techniques and widely recognized standards such as ARINC 653 and MILS in order to guarantee safety and security properties, and still improve overall performance.

Oral health in Libya: addressing the future challenges.

PubMed

Peeran, Syed Wali; Altaher, Omar Basheer; Peeran, Syed Ali; Alsaid, Fatma Mojtaba; Mugrabi, Marei Hamed; Ahmed, Aisha Mojtaba; Grain, Abdulgader

2014-01-01

Libya is a vast country situated in North Africa, having a relatively better functioning economy with a scanty population. This article is the first known attempt to review the current state of oral health care in Libya and to explore the present trends and future challenges. Libyan health system, oral health care, and human resources with the present status of dental education are reviewed comprehensively. A bibliographic study of oral health research and publications has been carried out. The results point toward a common indicator that oral health-related research is low. Strategies have to be developed to educate the medical and dental professionals, to update the current curriculum and enable the system to be competent in all aspects of oral health care management.

Oral health in Libya: addressing the future challenges

PubMed Central

Peeran, Syed Wali; Altaher, Omar Basheer; Peeran, Syed Ali; Alsaid, Fatma Mojtaba; Mugrabi, Marei Hamed; Ahmed, Aisha Mojtaba; Grain, Abdulgader

2014-01-01

Libya is a vast country situated in North Africa, having a relatively better functioning economy with a scanty population. This article is the first known attempt to review the current state of oral health care in Libya and to explore the present trends and future challenges. Libyan health system, oral health care, and human resources with the present status of dental education are reviewed comprehensively. A bibliographic study of oral health research and publications has been carried out. The results point toward a common indicator that oral health–related research is low. Strategies have to be developed to educate the medical and dental professionals, to update the current curriculum and enable the system to be competent in all aspects of oral health care management. PMID:24666627

Common Approach to Geoprocessing of Uav Data across Application Domains

NASA Astrophysics Data System (ADS)

Percivall, G. S.; Reichardt, M.; Taylor, T.

2015-08-01

UAVs are a disruptive technology bringing new geographic data and information to many application domains. UASs are similar to other geographic imagery systems so existing frameworks are applicable. But the diversity of UAVs as platforms along with the diversity of available sensors are presenting challenges in the processing and creation of geospatial products. Efficient processing and dissemination of the data is achieved using software and systems that implement open standards. The challenges identified point to the need for use of existing standards and extending standards. Results from the use of the OGC Sensor Web Enablement set of standards are presented. Next steps in the progress of UAVs and UASs may follow the path of open data, open source and open standards.

Global Precipitation Measurement (GPM) Orbit Design and Autonomous Maneuvers

NASA Technical Reports Server (NTRS)

Folta, David; Mendelsohn, Chad

2003-01-01

The NASA Goddard Space Flight Center's Global Precipitation Measurement (GPM) mission will meet a challenge of measuring worldwide precipitation every three hours. The GPM spacecraft, part of a constellation, will be required to maintain a circular orbit in a high drag environment to accomplish this challenge. Analysis by the Flight Dynamics Analysis Branch has shown that the prime orbit altitude of 40% is necessary to prevent ground track repeating. Combined with goals to minimize maneuver impacts to science data collection and enabling reasonable long-term orbit predictions, the GPM project has decided to fly an autonomous maneuver system. This system is a derivative of the successful New Millennium Program technology flown onboard the Earth Observing-1 mission. This paper presents the driving science requirements and goals of the mission and shows how they will be met. Analysis of the orbit optimization and the AV requirements for several ballistic properties are presented. The architecture of the autonomous maneuvering system to meet the goals and requirements is presented along with simulations using a GPM prototype. Additionally, the use of the GPM autonomous system to mitigate possible collision avoidance and to aid other spacecraft systems during navigation outages is explored.

Challenges to clinical deployment of upper limb neuroprostheses.

PubMed

Triolo, R; Nathan, R; Handa, Y; Keith, M; Betz, R R; Carroll, S; Kantor, C

1996-04-01

The technology for functional neuromuscular stimulation (FNS) as a means of providing upper limb function to people with tetraplegia has been under development by three clinical research groups for almost two decades. This paper presents the current status of the clinical trials of three FNS systems: a noninvasive system built into a cosmetic forearm splint, a 30-channel percutaneous system, and an 8-channel implantable system. The complexity of FNS systems and the unique characteristics of the individuals to whom they are applied combine to create many clinical and technical challenges that must be addressed before the devices can be deployed. The emerging challenges to widespread clinical introduction of FNS systems for hand and arm function are identified and analyzed. In addition to the demands of designed and conducting the clinical trials to satisfy regulatory requirements, the lack of knowledge, skepticism, and the complacency on the part of potential FNS recipients, as well as of rehabilitation professionals, must be overcome through education and careful consideration of economic and societal factors in the design of clinical systems.

Implementation of workflow engine technology to deliver basic clinical decision support functionality.

PubMed

Huser, Vojtech; Rasmussen, Luke V; Oberg, Ryan; Starren, Justin B

2011-04-10

Workflow engine technology represents a new class of software with the ability to graphically model step-based knowledge. We present application of this novel technology to the domain of clinical decision support. Successful implementation of decision support within an electronic health record (EHR) remains an unsolved research challenge. Previous research efforts were mostly based on healthcare-specific representation standards and execution engines and did not reach wide adoption. We focus on two challenges in decision support systems: the ability to test decision logic on retrospective data prior prospective deployment and the challenge of user-friendly representation of clinical logic. We present our implementation of a workflow engine technology that addresses the two above-described challenges in delivering clinical decision support. Our system is based on a cross-industry standard of XML (extensible markup language) process definition language (XPDL). The core components of the system are a workflow editor for modeling clinical scenarios and a workflow engine for execution of those scenarios. We demonstrate, with an open-source and publicly available workflow suite, that clinical decision support logic can be executed on retrospective data. The same flowchart-based representation can also function in a prospective mode where the system can be integrated with an EHR system and respond to real-time clinical events. We limit the scope of our implementation to decision support content generation (which can be EHR system vendor independent). We do not focus on supporting complex decision support content delivery mechanisms due to lack of standardization of EHR systems in this area. We present results of our evaluation of the flowchart-based graphical notation as well as architectural evaluation of our implementation using an established evaluation framework for clinical decision support architecture. We describe an implementation of a free workflow technology software suite (available at http://code.google.com/p/healthflow) and its application in the domain of clinical decision support. Our implementation seamlessly supports clinical logic testing on retrospective data and offers a user-friendly knowledge representation paradigm. With the presented software implementation, we demonstrate that workflow engine technology can provide a decision support platform which evaluates well against an established clinical decision support architecture evaluation framework. Due to cross-industry usage of workflow engine technology, we can expect significant future functionality enhancements that will further improve the technology's capacity to serve as a clinical decision support platform.

Electronic health records approaches and challenges: a comparison between Malaysia and four East Asian countries.

PubMed

Abd Ghani, Mohd Khanapi; Bali, Rajeev K; Naguib, Raouf N G; Marshall, Ian M

2008-01-01

An integrated Lifetime Health Record (LHR) is fundamental for achieving seamless and continuous access to patient medical information and for the continuum of care. However, the aim has not yet been fully realised. The efforts are actively progressing around the globe. Every stage of the development of the LHR initiatives had presented peculiar challenges. The best lessons in life are those of someone else's experiences. This paper presents an overview of the development approaches undertaken by four East Asian countries in implementing a national Electronic Health Record (EHR) in the public health system. The major challenges elicited from the review including integration efforts, process reengineering, funding, people, and law and regulation will be presented, compared, discussed and used as lessons learned for the further development of the Malaysian integrated LHR.

Commercially Hosted Government Payloads: Lessons from Recent Programs

NASA Technical Reports Server (NTRS)

Andraschko, Mark A.; Antol, Jeffrey; Horan, Stephen; Neil, Doreen

2011-01-01

In a commercially hosted operational mode, a scientific instrument or operational device is attached to a spacecraft but operates independently from the spacecraft s primary mission. Despite the expected benefits of this arrangement, there are few examples of hosted payload programs actually being executed by government organizations. The lack of hosted payload programs is largely driven by programmatic challenges, both real and perceived, rather than by technical challenges. Partly for these reasons, NASA has not sponsored a hosted payload program, in spite of the benefits and visible community interest in doing so. In the interest of increasing the use of hosted payloads across the space community, this paper seeks to alleviate concerns about hosted payloads by identifying these programmatic challenges and presenting ways in which they can be avoided or mitigated. Despite the challenges, several recent hosted payload programs have been successfully completed or are currently in progress. This paper presents an assessment of these programs, with a focus on acquisition, costs, schedules, risks, and other programmatic aspects. The hosted payloads included in this study are the Federal Aviation Administration's Wide Area Augmentation System (WAAS) payloads, United States Coast Guard's Automatic Identification System (AIS) demonstration payload, Department of Defense's IP Router In Space (IRIS) demonstration payload, the United States Air Force's Commercially Hosted Infrared Payload (CHIRP), and the Australian Defence Force's Ultra High Frequency (UHF) payload. General descriptions of each of these programs are presented along with issues that have been encountered and lessons learned from those experiences. A set of recommended approaches for future hosted payload programs is presented, with a focus on addressing risks or potential problem areas through smart and flexible contracting up front. This set of lessons and recommendations is broadly applicable to future hosted payload programs, whether they are technology demonstrations, communications systems, or operational sensors. Additionally, we present a basic cost model for commercial access to space for hosted payloads as a function of payload mass

Parallel Index and Query for Large Scale Data Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chou, Jerry; Wu, Kesheng; Ruebel, Oliver

2011-07-18

Modern scientific datasets present numerous data management and analysis challenges. State-of-the-art index and query technologies are critical for facilitating interactive exploration of large datasets, but numerous challenges remain in terms of designing a system for process- ing general scientific datasets. The system needs to be able to run on distributed multi-core platforms, efficiently utilize underlying I/O infrastructure, and scale to massive datasets. We present FastQuery, a novel software framework that address these challenges. FastQuery utilizes a state-of-the-art index and query technology (FastBit) and is designed to process mas- sive datasets on modern supercomputing platforms. We apply FastQuery to processing ofmore » a massive 50TB dataset generated by a large scale accelerator modeling code. We demonstrate the scalability of the tool to 11,520 cores. Motivated by the scientific need to search for inter- esting particles in this dataset, we use our framework to reduce search time from hours to tens of seconds.« less

US EPA - A*Star Partnership - Accelerating the Acceptance of ...

EPA Pesticide Factsheets

The path for incorporating new alternative methods and technologies into quantitative chemical risk assessment poses a diverse set of scientific challenges. Some of these challenges include development of relevant and predictive test systems and computational models to integrate and extrapolate experimental data, and rapid characterization and acceptance of these systems and models. The series of presentations will highlight a collaborative effort between the U.S. Environmental Protection Agency (EPA) and the Agency for Science, Technology and Research (A*STAR) that is focused on developing and applying experimental and computational models for predicting chemical-induced liver and kidney toxicity, brain angiogenesis, and blood-brain-barrier formation. In addressing some of these challenges, the U.S. EPA and A*STAR collaboration will provide a glimpse of what chemical risk assessments could look like in the 21st century. Presentation on US EPA – A*STAR Partnership at international symposium on Accelerating the acceptance of next-generation sciences and their application to regulatory risk assessment in Singapore.

ISS Regenerative Life Support: Challenges and Success in the Quest for Long-Term Habitability in Space

NASA Technical Reports Server (NTRS)

Bazley, Jesse A.

2011-01-01

This presentation will discuss the International Space Station s (ISS) Regenerative Environmental Control and Life Support System (ECLSS) operations with discussion of the on-orbit lessons learned, specifically regarding the challenges that have been faced as the system has expanded with a growing ISS crew. Over the 10 year history of the ISS, there have been numerous challenges, failures, and triumphs in the quest to keep the crew alive and comfortable. Successful operation of the ECLSS not only requires maintenance of the hardware, but also management of the station resources in case of hardware failure or missed re-supply. This involves effective communication between the primary International Partners (NASA and Roskosmos) and the secondary partners (JAXA and ESA) in order to keep a reserve of the contingency consumables and allow for re-supply of failed hardware. The ISS ECLSS utilizes consumables storage for contingency usage as well as longer-term regenerative systems, which allow for conservation of the expensive resources brought up by re-supply vehicles. This long-term hardware, and the interactions with software, was a challenge for Systems Engineers when they were designed and require multiple operational workarounds in order to function continuously. On a day-to-day basis, the ECLSS provides big challenges to the on console controllers. Main challenges involve the utilization of the resources that have been brought up by the visiting vehicles prior to undocking, balance of contributions between the International Partners for both systems and resources, and maintaining balance between the many interdependent systems, which includes providing the resources they need when they need it. The current biggest challenge for ECLSS is the Regenerative ECLSS system, which continuously recycles urine and condensate water into drinking water and oxygen. These systems were brought to full functionality on STS-126 (ULF-2) mission. Through system failures and recovery, the ECLSS console has learned how to balance the water within the systems, store and use water for contingencies, and continue to work with the International Partners for short-term failures. Through these challenges and the system failures, the most important lesson learned has been the importance of redundancy and operational workarounds. It is only because of the flexibility of the hardware and the software that flight controllers have the opportunity to continue operating the system as a whole for mission success.

NASA Integrated Systems Research with an Environmental Focus

NASA Technical Reports Server (NTRS)

Wolfe, Jean; Collier, Fay

2010-01-01

This slide presentation reviews the Integrated Systems Research Program (ISRP) with a focus on the work being done on reduction of environmental impact from aeronautics. The focus of the ISRP is to Conduct research at an integrated system-level on promising concepts and technologies and explore, assess, or demonstrate the benefits in a relevant environment. The presentation reviews the criteria for an ISRP project, and discusses the Environmentally Responsible Aviation (ERA) project, and the technical challenges.

Integration Science and Technology of Silicon-Based Ceramics and Composites:Technical Challenges and Opportunities

NASA Technical Reports Server (NTRS)

Singh, M.

2013-01-01

Ceramic integration technologies enable hierarchical design and manufacturing of intricate ceramic and composite parts starting with geometrically simpler units that are subsequently joined to themselves and/or to metals to create components with progressively higher levels of complexity and functionality. However, for the development of robust and reliable integrated systems with optimum performance for high temperature applications, detailed understanding of various thermochemical and thermomechanical factors is critical. Different technical approaches are required for the integration of ceramic to ceramic and ceramic to metal systems. Active metal brazing, in particular, is a simple and cost-effective method to integrate ceramic to metallic components. Active braze alloys usually contain a reactive filler metal (e.g., Ti, Cr, V, Hf etc) that promotes wettability and spreading by inducing chemical reactions with the ceramics and composites. In this presentation, various examples of brazing of silicon nitride to themselves and to metallic systems are presented. Other examples of joining of ceramic composites (C/SiC and SiC/SiC) using ceramic interlayers and the resulting microstructures are also presented. Thermomechanical characterization of joints is presented for both types of systems. In addition, various challenges and opportunities in design, fabrication, and testing of integrated similar (ceramic-ceramic) and dissimilar (ceramic-metal) material systems will be discussed. Potential opportunities and need for the development of innovative design philosophies, approaches, and integrated system testing under simulated application conditions will also be presented.

Evaluation of Graph Pattern Matching Workloads in Graph Analysis Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hong, Seokyong; Lee, Sangkeun; Lim, Seung-Hwan

2016-01-01

Graph analysis has emerged as a powerful method for data scientists to represent, integrate, query, and explore heterogeneous data sources. As a result, graph data management and mining became a popular area of research, and led to the development of plethora of systems in recent years. Unfortunately, the number of emerging graph analysis systems and the wide range of applications, coupled with a lack of apples-to-apples comparisons, make it difficult to understand the trade-offs between different systems and the graph operations for which they are designed. A fair comparison of these systems is a challenging task for the following reasons:more » multiple data models, non-standardized serialization formats, various query interfaces to users, and diverse environments they operate in. To address these key challenges, in this paper we present a new benchmark suite by extending the Lehigh University Benchmark (LUBM) to cover the most common capabilities of various graph analysis systems. We provide the design process of the benchmark, which generalizes the workflow for data scientists to conduct the desired graph analysis on different graph analysis systems. Equipped with this extended benchmark suite, we present performance comparison for nine subgraph pattern retrieval operations over six graph analysis systems, namely NetworkX, Neo4j, Jena, Titan, GraphX, and uRiKA. Through the proposed benchmark suite, this study reveals both quantitative and qualitative findings in (1) implications in loading data into each system; (2) challenges in describing graph patterns for each query interface; and (3) different sensitivity of each system to query selectivity. We envision that this study will pave the road for: (i) data scientists to select the suitable graph analysis systems, and (ii) data management system designers to advance graph analysis systems.« less

Intelligent Transportation Systems (ITS) in the NPS : 2005 baseline inventory and preliminary program assessment

DOT National Transportation Integrated Search

2006-01-19

This report presents the current status of Intelligent Transportation Systems (ITS) within the 398 national parks managed by the National Park Service (NPS), discusses the potential of ITS to address the often unique transportation challenges faced b...

Data systems and computer science space data systems: Onboard networking and testbeds

NASA Technical Reports Server (NTRS)

Dalton, Dan

1991-01-01

The technical objectives are to develop high-performance, space-qualifiable, onboard computing, storage, and networking technologies. The topics are presented in viewgraph form and include the following: justification; technology challenges; program description; and state-of-the-art assessment.

Geographic information systems : challenges to effective data sharing : statement of Linda D. Koontz, Director, Information management issues

DOT National Transportation Integrated Search

2003-06-10

Geographic information systems (GIS) manipulate, analyze, and graphically present an array of information associated with geographic locations, have been invaluable to all levels of government. The federal government has long been attempting to devel...

Shuttle payload S-band communications system

NASA Technical Reports Server (NTRS)

Batson, B. H.; Teasdale, W. E.; Pawlowski, J. F.; Schmidt, O. L.

1985-01-01

The Shuttle payload S-band communications system design, operational capabilities, and performance are described in detail. System design requirements, overall system and configuration and operation, and laboratory/flight test results are presented. Payload communications requirements development is discussed in terms of evolvement of requirements as well as the resulting technical challenges encountered in meeting the initial requirements. Initial design approaches are described along with cost-saving initiatives that subsequently had to be made. The resulting system implementation that was finally adopted is presented along with a functional description of the system operation. A description of system test results, problems encountered, how the problems were solved, and the system flight experience to date is presented. Finally, a summary of the advancements made and the lessons learned is discussed.

E-Learning in Supplemental Educational Systems in Taiwan: Present Status and Future Challenges

ERIC Educational Resources Information Center

Zhang, Ke; Hung, Jui-Long

2009-01-01

As Taiwan's full-scale e-learning initiatives moved to the seventh year in 2009, the current status and challenges of e-learning development there are yet to be fully understood. Further extending Zhang and Hung's (2006) investigation on e-learning in all universities and colleges in Taiwan, this study investigated the after-school programs (ASPs)…

Conflicting short and long-term management goals: Fire effects in endangered golden-cheeked warbler (Setophaga chrysoparia) habitat

Treesearch

Christina M. Andruk; Norma L. Fowler

2015-01-01

Decades of fire suppression have significantly altered the vegetation structure and composition of savannas, woodlands, and forests. The presence of endangered species and other species of conservation concern in these fire-suppressed systems makes re-introducing fire more challenging. In oak-juniper woodlands of central Texas, we are presented with the challenge of re...

Model-based nonlinear control of hydraulic servo systems: Challenges, developments and perspectives

NASA Astrophysics Data System (ADS)

Yao, Jianyong

2018-06-01

Hydraulic servo system plays a significant role in industries, and usually acts as a core point in control and power transmission. Although linear theory-based control methods have been well established, advanced controller design methods for hydraulic servo system to achieve high performance is still an unending pursuit along with the development of modern industry. Essential nonlinearity is a unique feature and makes model-based nonlinear control more attractive, due to benefit from prior knowledge of the servo valve controlled hydraulic system. In this paper, a discussion for challenges in model-based nonlinear control, latest developments and brief perspectives of hydraulic servo systems are presented: Modelling uncertainty in hydraulic system is a major challenge, which includes parametric uncertainty and time-varying disturbance; some specific requirements also arise ad hoc difficulties such as nonlinear friction during low velocity tracking, severe disturbance, periodic disturbance, etc.; to handle various challenges, nonlinear solutions including parameter adaptation, nonlinear robust control, state and disturbance observation, backstepping design and so on, are proposed and integrated, theoretical analysis and lots of applications reveal their powerful capability to solve pertinent problems; and at the end, some perspectives and associated research topics (measurement noise, constraints, inner valve dynamics, input nonlinearity, etc.) in nonlinear hydraulic servo control are briefly explored and discussed.

Robot deployment in long-term care : Case study on using a mobile robot to support physiotherapy.

PubMed

Gerling, K; Hebesberger, D; Dondrup, C; Körtner, T; Hanheide, M

2016-06-01

Healthcare systems in industrialized countries face the challenge of providing care for a growing number of elderly people. Information technology has the possibility of facilitating this process by providing support for nursing staff and improving the well-being of the elderly through a variety of support systems. Little is known about the challenges that arise from the deployment of technology in care settings; however, the integration of technology into care is one of the core determinants of successful support. This article presents the challenges and options associated with the integration of technology into care using the example of a mobile robot to support physiotherapy for elderly people with cognitive impairment in the European project Spatio-Temporal Representations and Activities for Cognitive Control in Long-Term Scenarios (STRANDS). This article presents the technical challenges associated with the introduction of robots in the context of care as well as the perspectives of physiotherapists involved and an overview of information and experiences gained. It is hoped that this will provide useful information for the work of researchers and practitioners wishing to integrate robotic aids into the caregiving process.

Global nurse leader perspectives on health systems and workforce challenges.

PubMed

Gantz, Nancy Rollins; Sherman, Rose; Jasper, Melanie; Choo, Chua Gek; Herrin-Griffith, Donna; Harris, Kathy

2012-05-01

As part of the 2011 annual American Organization of Nurse Executives conference held in San Diego, California, a session was presented that focused on nursing workforce and health systems challenges from a global perspective. This article includes content addressed during the session representing nurse leader perspectives from the UK, Singapore and the USA. Recent events in global economic markets have highlighted the interdependence of countries. There is now a global focus on health-care costs and quality as government leaders struggle to reduce budgets and remain solvent. Finding solutions to these complex problems requires that nurse leaders adopt more of a world view and network with one another as they look for best practices and creative strategies. Nursing leadership challenges such as staffing, competency development, ageing populations, reduced health-care funding and maintaining quality are now common global problems. There is a need for innovation in nursing practice to accommodate the enormous challenges facing nursing's future. Opportunities on an international scale for nurse leaders to have dialogue and network, such as the conference presentation discussed in this article, will become increasingly more important to facilitate the development of innovative leadership strategies. © 2012 Blackwell Publishing Ltd.

Theoretical modelling and optimization of bubble column dehumidifier for a solar driven humidification-dehumidification system

NASA Astrophysics Data System (ADS)

Ranjitha, P. Raj; Ratheesh, R.; Jayakumar, J. S.; Balakrishnan, Shankar

2018-02-01

Availability and utilization of energy and water are the top most global challenges being faced by the new millennium. At the present state water scarcity has become a global as well as a regional challenge. 40 % of world population faces water shortage. Challenge of water scarcity can be tackled only with increase in water supply beyond what is obtained from hydrological cycle. This can be achieved either by desalinating the sea water or by reusing the waste water. High energy requirement need to be overcome for either of the two processes. Of many desalination technologies, humidification dehumidification (HDH) technology powered by solar energy is widely accepted for small scale production. Detailed optimization studies on system have the potential to effectively utilize the solar energy for brackish water desalination. Dehumidification technology, specifically, require further study because the dehumidifier effectiveness control the energetic performance of the entire HDH system. The reason attributes to the high resistance involved to diffuse dilute vapor through air in a dehumidifier. The present work intends to optimize the design of a bubble column dehumidifier for a solar energy driven desalination process. Optimization is carried out using Matlab simulation. Design process will identify the unique needs of a bubble column dehumidifier in HDH system.

Quality Assurance in Higher Education in Spain: An Overview of the Accreditation System

ERIC Educational Resources Information Center

Ríos, Cristina

2015-01-01

Accreditation has become an important issue in Spain. This paper presents an overview of Spain's accreditation system; a system which is relatively new and has evolved rapidly, fostered by legislative mandates which established accreditation bodies to regulate the quality of higher education institutions. One of the initial challenges faced by…

Visualizing and Quantifying the Suppressive Effects of Glucocorticoids on the Tadpole Immune System in Vivo

ERIC Educational Resources Information Center

Schreiber, Alexander M.

2011-01-01

A challenging topic in undergraduate physiology courses is the complex interaction between the vertebrate endocrine system and the immune system. There are relatively few established and accessible laboratory exercises available to instructors to help their students gain a working understanding of these interactions. The present laboratory module…

Vertical Integration of System-on-Chip Concepts in the Digital Design Curriculum

ERIC Educational Resources Information Center

Tang, Ying; Head, L. M.; Ramachandran, R. P.; Chatman, L. M.

2011-01-01

The rapid evolution of System-on-Chip (SoC) challenges academic curricula to keep pace with multidisciplinary/interdisciplinary system thinking. This paper presents a curricular prototype that cuts across artificial course boundaries and provides a meaningful exploration of diverse facets of SoC design. Specifically, experimental contents of a…

An Integrated Learning Management System for Location-Based Mobile Learning

ERIC Educational Resources Information Center

Sailer, Christian; Kiefer, Peter; Raubal, Martin

2015-01-01

This paper discusses the relevance and challenges of a location-based learning platform that supports mobile learning in education. We present the design of an integrated management system for location-based mobile learning. Independent of the taught subject, the objective of the system is an easy-to-understand user interface for both - teachers…

Recognition of medication information from discharge summaries using ensembles of classifiers.

PubMed

Doan, Son; Collier, Nigel; Xu, Hua; Pham, Hoang Duy; Tu, Minh Phuong

2012-05-07

Extraction of clinical information such as medications or problems from clinical text is an important task of clinical natural language processing (NLP). Rule-based methods are often used in clinical NLP systems because they are easy to adapt and customize. Recently, supervised machine learning methods have proven to be effective in clinical NLP as well. However, combining different classifiers to further improve the performance of clinical entity recognition systems has not been investigated extensively. Combining classifiers into an ensemble classifier presents both challenges and opportunities to improve performance in such NLP tasks. We investigated ensemble classifiers that used different voting strategies to combine outputs from three individual classifiers: a rule-based system, a support vector machine (SVM) based system, and a conditional random field (CRF) based system. Three voting methods were proposed and evaluated using the annotated data sets from the 2009 i2b2 NLP challenge: simple majority, local SVM-based voting, and local CRF-based voting. Evaluation on 268 manually annotated discharge summaries from the i2b2 challenge showed that the local CRF-based voting method achieved the best F-score of 90.84% (94.11% Precision, 87.81% Recall) for 10-fold cross-validation. We then compared our systems with the first-ranked system in the challenge by using the same training and test sets. Our system based on majority voting achieved a better F-score of 89.65% (93.91% Precision, 85.76% Recall) than the previously reported F-score of 89.19% (93.78% Precision, 85.03% Recall) by the first-ranked system in the challenge. Our experimental results using the 2009 i2b2 challenge datasets showed that ensemble classifiers that combine individual classifiers into a voting system could achieve better performance than a single classifier in recognizing medication information from clinical text. It suggests that simple strategies that can be easily implemented such as majority voting could have the potential to significantly improve clinical entity recognition.

Post-Flight Analysis of GPSR Performance During Orion Exploration Flight Test 1

NASA Technical Reports Server (NTRS)

Barker, Lee; Mamich, Harvey; McGregor, John

2016-01-01

On 5 December 2014, the first test flight of the Orion Multi-Purpose Crew Vehicle executed a unique and challenging flight profile including an elevated re-entry velocity and steeper flight path angle to envelope lunar re-entry conditions. A new navigation system including a single frequency (L1) GPS receiver was evaluated for use as part of the redundant navigation system required for human space flight. The single frequency receiver was challenged by a highly dynamic flight environment including flight above low Earth orbit, as well as single frequency operation with ionospheric delay present. This paper presents a brief description of the GPS navigation system, an independent analysis of flight telemetry data, and evaluation of the GPSR performance, including evaluation of the ionospheric model employed to supplement the single frequency receiver. Lessons learned and potential improvements will be discussed.

Development of noSQL data storage for the ATLAS PanDA Monitoring System

NASA Astrophysics Data System (ADS)

Potekhin, M.; ATLAS Collaboration

2012-06-01

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with a R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic loads.

Challenges in Improving Latino College Enrollment: Opportunities for Systemic Change Viewpoints from California

ERIC Educational Resources Information Center

Tomas Rivera Policy Institute, 2005

2005-01-01

This document includes presentation summaries and policy recommendations from the 2004 Tomas Rivera Policy Institute (TRPI) Education Conference: (1) The Present and Coming Crisis: Demography and Education (Dowell Myers and Estela Mara Bensimon); (2) A View from the Academic Community (Moderators: Jorge Haynes and Jamilah Moore; Presenters:…

Neonatal endocrine emergencies: a primer for the emergency physician.

PubMed

Park, Elizabeth; Pearson, Nadia M; Pillow, M Tyson; Toledo, Alexander

2014-05-01

The resuscitation principles of securing the airway and stabilizing hemodynamics remain the same in any neonatal emergency. However, stabilizing endocrine disorders may prove especially challenging. Several organ systems are affected simultaneously and the clinical presentation can be subtle. Although not all-inclusive, the implementation of newborn screening tests has significantly reduced morbidity and mortality in neonates. Implementing routine screening tests worldwide and improving the accuracy of present tests remains the challenge for healthcare providers. With further study of these disorders and best treatment practices we can provide neonates presenting to the emergency department with the best possible outcomes. Copyright © 2014 Elsevier Inc. All rights reserved.

50th Anniversary Perspective: A Perspective on Polyelectrolyte Solutions

PubMed Central

2017-01-01

From the beginning of life with the information-containing polymers until the present era of a plethora of water-based materials in health care industry and biotechnology, polyelectrolytes are ubiquitous with a broad range of structural and functional properties. The main attribute of polyelectrolyte solutions is that all molecules are strongly correlated both topologically and electrostatically in their neutralizing background of charged ions in highly polarizable solvent. These strong correlations and the necessary use of numerous variables in experiments on polyelectrolytes have presented immense challenges toward fundamental understanding of the various behaviors of charged polymeric systems. This Perspective presents the author’s subjective summary of several conceptual advances and the remaining persistent challenges in the contexts of charge and size of polymers, structures in homogeneous solutions, thermodynamic instability and phase transitions, structural evolution with oppositely charged polymers, dynamics in polyelectrolyte solutions, kinetics of phase separation, mobility of charged macromolecules between compartments, and implications to biological systems. PMID:29296029

Fabrication of Circuit QED Quantum Processors, Part 2: Advanced Semiconductor Manufacturing Perspectives

NASA Astrophysics Data System (ADS)

Michalak, D. J.; Bruno, A.; Caudillo, R.; Elsherbini, A. A.; Falcon, J. A.; Nam, Y. S.; Poletto, S.; Roberts, J.; Thomas, N. K.; Yoscovits, Z. R.; Dicarlo, L.; Clarke, J. S.

Experimental quantum computing is rapidly approaching the integration of sufficient numbers of quantum bits for interesting applications, but many challenges still remain. These challenges include: realization of an extensible design for large array scale up, sufficient material process control, and discovery of integration schemes compatible with industrial 300 mm fabrication. We present recent developments in extensible circuits with vertical delivery. Toward the goal of developing a high-volume manufacturing process, we will present recent results on a new Josephson junction process that is compatible with current tooling. We will then present the improvements in NbTiN material uniformity that typical 300 mm fabrication tooling can provide. While initial results on few-qubit systems are encouraging, advanced processing control is expected to deliver the improvements in qubit uniformity, coherence time, and control required for larger systems. Research funded by Intel Corporation.

Miniature objective lens for array digital pathology: design improvement based on clinical evaluation

NASA Astrophysics Data System (ADS)

McCall, Brian; Pierce, Mark; Graviss, Edward A.; Richards-Kortum, Rebecca R.; Tkaczyk, Tomasz S.

2016-03-01

A miniature objective designed for digital detection of Mycobacterium tuberculosis (MTB) was evaluated for diagnostic accuracy. The objective was designed for array microscopy, but fabricated and evaluated at this stage of development as a single objective. The counts and diagnoses of patient samples were directly compared for digital detection and standard microscopy. The results were found to be correlated and highly concordant. The evaluation of this lens by direct comparison to standard fluorescence sputum smear microscopy presented unique challenges and led to some new insights in the role played by the system parameters of the microscope. The design parameters and how they were developed are reviewed in light of these results. New system parameters are proposed with the goal of easing the challenges of evaluating the miniature objective and maintaining the optical performance that produced the agreeable results presented without over-optimizing. A new design is presented that meets and exceeds these criteria.

Engineering the System and Technical Integration

NASA Technical Reports Server (NTRS)

Blair, J. C.; Ryan, R. S.; Schutzenhofer, L. A.

2011-01-01

Approximately 80% of the problems encountered in aerospace systems have been due to a breakdown in technical integration and/or systems engineering. One of the major challenges we face in designing, building, and operating space systems is: how is adequate integration achieved for the systems various functions, parts, and infrastructure? This Contractor Report (CR) deals with part of the problem of how we engineer the total system in order to achieve the best balanced design. We will discuss a key aspect of this question - the principle of Technical Integration and its components, along with management and decision making. The CR will first provide an introduction with a discussion of the Challenges in Space System Design and meeting the challenges. Next is an overview of Engineering the System including Technical Integration. Engineering the System is expanded to include key aspects of the Design Process, Lifecycle Considerations, etc. The basic information and figures used in this CR were presented in a NASA training program for Program and Project Managers Development (PPMD) in classes at Georgia Tech and at Marshall Space Flight Center (MSFC). Many of the principles and illustrations are extracted from the courses we teach for MSFC.

Sensor Network Middleware for Cyber-Physical Systems: Opportunities and Challenges

NASA Astrophysics Data System (ADS)

Singh, G.

2015-12-01

Wireless Sensor Network middleware typically provides abstractions for common tasks such as atomicity, synchronization and communication with the intention of isolating the developers of distributed applications from lower-level details of the underlying platforms. Developing middleware to meet the performance constraints of applications is an important challenge. Although one would like to develop generic middleware services which can be used in a variety of different applications, efficiency considerations often force developers to design middleware and algorithms customized to specific operational contexts. This presentation will discuss techniques to design middleware that is customizable to suit the performance needs of specific applications. We also discuss the challenges poised in designing middleware for pervasive sensor networks and cyber-physical systems with specific focus on environmental monitoring.

Thermoelectric Energy Conversion: Future Directions and Technology Development Needs

NASA Technical Reports Server (NTRS)

Fleurial, Jean-Pierre

2007-01-01

This viewgraph presentation reviews the process of thermoelectric energy conversion along with key technology needs and challenges. The topics include: 1) The Case for Thermoelectrics; 2) Advances in Thermoelectrics: Investment Needed; 3) Current U.S. Investment (FY07); 4) Increasing Thermoelectric Materials Conversion Efficiency Key Science Needs and Challenges; 5) Developing Advanced TE Components & Systems Key Technology Needs and Challenges; 6) Thermoelectrics; 7) 200W Class Lightweight Portable Thermoelectric Generator; 8) Hybrid Absorption Cooling/TE Power Cogeneration System; 9) Major Opportunities in Energy Industry; 10) Automobile Waste Heat Recovery; 11) Thermoelectrics at JPL; 12) Recent Advances at JPL in Thermoelectric Converter Component Technologies; 13) Thermoelectrics Background on Power Generation and Cooling Operational Modes; 14) Thermoelectric Power Generation; and 15) Thermoelectric Cooling.

Bacillus sp. LT3 improves the survival of gnotobiotic brine shrimp (Artemia franciscana) larvae challenged with Vibrio campbellii by enhancing the innate immune response and by decreasing the activity of shrimp-associated vibrios.

PubMed

Niu, Yufeng; Defoirdt, Tom; Baruah, Kartik; Van de Wiele, Tom; Dong, Shuanglin; Bossier, Peter

2014-10-10

Bacteria belonging to the genus Bacillus are amongst the most intensively studied group of bacteria for use as probiotics in aquaculture. However, the exact mechanism of action of these bacteria is often not well described, and the microbiota that are naturally present in cultures of test organisms often compromise the interpretation of the results. The present study aimed to evaluate the putative probiotic effect of Bacillus sp. LT3 in a model system with gnotobiotic brine shrimp Artemia franciscana larvae. The strain significantly increased the survival of brine shrimp larvae challenged with Vibrio campbellii when administered 6h before the challenge. Under these conditions, LT3 was able to colonize the brine shrimp gastrointestinal tract and to decrease the in vivo pathogen activity as indicated by the bioluminescence of the V. campbellii associated with brine shrimp larvae. In order to investigate the effect of the Bacillus strain on the innate immune system of the brine shrimp larvae, prophenoloxidase and transglutaminase mRNA levels were monitored, while heat shock protein 70 mRNA levels were measured as an indicator of physiological stress. Interestingly, 12h after challenge, the prophenoloxidase mRNA level in the larvae pre-treated with LT3 and challenged with V. campbellii was approximately 8-fold higher than in the other treatments. Further, a decreased mRNA level of transglutaminase gene and heat shock protein 70 gene suggested that pretreatment with LT3 results in less stress and tissue damage in the brine shrimp larvae upon V. campbellii challenge. These results indicated that Bacillus sp. LT3 could improve the survival of brine shrimp larvae when challenged with pathogenic V. campbellii, both by decreasing the in vivo activity of the pathogen and by priming the innate immune response through activating the prophenoloxidase system. Copyright © 2014 Elsevier B.V. All rights reserved.

Integrating MBSE into Ongoing Projects: Requirements Validation and Test Planning for the ISS SAFER

NASA Technical Reports Server (NTRS)

Anderson, Herbert A.; Williams, Antony; Pierce, Gregory

2016-01-01

The International Space Station (ISS) Simplified Aid for Extra Vehicular Activity (EVA) Rescue (SAFER) is the spacewalking astronaut's final safety measure against separating from the ISS and being unable to return safely. Since the late 1990s, the SAFER has been a standard element of the spacewalking astronaut's equipment. The ISS SAFER project was chartered to develop a new block of SAFER units using a highly similar design to the legacy SAFER (known as the USA SAFER). An on-orbit test module was also included in the project to enable periodic maintenance/propulsion system checkout on the ISS SAFER. On the ISS SAFER project, model-based systems engineering (MBSE) was not the initial systems engineering (SE) approach, given the volume of heritage systems engineering and integration (SE&I) products. The initial emphasis was ensuring traceability to ISS program standards as well as to legacy USA SAFER requirements. The requirements management capabilities of the Cradle systems engineering tool were to be utilized to that end. During development, however, MBSE approaches were applied selectively to address specific challenges in requirements validation and test and verification (T&V) planning, which provided measurable efficiencies to the project. From an MBSE perspective, ISS SAFER development presented a challenge and an opportunity. Addressing the challenge first, the project was tasked to use the original USA SAFER operational and design requirements baseline, with a number of additional ISS program requirements to address evolving certification expectations for systems operating on the ISS. Additionally, a need to redesign the ISS SAFER avionics architecture resulted in a set of changes to the design requirements baseline. Finally, the project added an entirely new functionality for on-orbit maintenance. After initial requirements integration, the system requirements count was approaching 1000, which represented a growth of 4x over the original USA SAFER system. This presented the challenge - How to confirm that this new set of requirements set would result in the creation of the desired capability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barstow, Del R; Patlolla, Dilip Reddy; Mann, Christopher J

Abstract The data captured by existing standoff biometric systems typically has lower biometric recognition performance than their close range counterparts due to imaging challenges, pose challenges, and other factors. To assist in overcoming these limitations systems typically perform in a multi-modal capacity such as Honeywell s Combined Face and Iris (CFAIRS) [21] system. While this improves the systems performance, standoff systems have yet to be proven as accurate as their close range equivalents. We will present a standoff system capable of operating up to 7 meters in range. Unlike many systems such as the CFAIRS our system captures high qualitymore » 12 MP video allowing for a multi-sample as well as multi-modal comparison. We found that for standoff systems multi-sample improved performance more than multi-modal. For a small test group of 50 subjects we were able to achieve 100% rank one recognition performance with our system.« less

ASME Material Challenges for Advanced Reactor Concepts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piyush Sabharwall; Ali Siahpush

2013-07-01

This study presents the material Challenges associated with Advanced Reactor Concept (ARC) such as the Advanced High Temperature Reactor (AHTR). ACR are the next generation concepts focusing on power production and providing thermal energy for industrial applications. The efficient transfer of energy for industrial applications depends on the ability to incorporate cost-effective heat exchangers between the nuclear heat transport system and industrial process heat transport system. The heat exchanger required for AHTR is subjected to a unique set of conditions that bring with them several design challenges not encountered in standard heat exchangers. The corrosive molten salts, especially at highermore » temperatures, require materials throughout the system to avoid corrosion, and adverse high-temperature effects such as creep. Given the very high steam generator pressure of the supercritical steam cycle, it is anticipated that water tube and molten salt shell steam generators heat exchanger will be used. In this paper, the ASME Section III and the American Society of Mechanical Engineers (ASME) Section VIII requirements (acceptance criteria) are discussed. Also, the ASME material acceptance criteria (ASME Section II, Part D) for high temperature environment are presented. Finally, lack of ASME acceptance criteria for thermal design and analysis are discussed.« less

Big Data in Designing Clinical Trials: Opportunities and Challenges

PubMed Central

Mayo, Charles S.; Matuszak, Martha M.; Schipper, Matthew J.; Jolly, Shruti; Hayman, James A.; Ten Haken, Randall K.

2017-01-01

Emergence of big data analytics resource systems (BDARSs) as a part of routine practice in Radiation Oncology is on the horizon. Gradually, individual researchers, vendors, and professional societies are leading initiatives to create and demonstrate use of automated systems. What are the implications for design of clinical trials, as these systems emerge? Gold standard, randomized controlled trials (RCTs) have high internal validity for the patients and settings fitting constraints of the trial, but also have limitations including: reproducibility, generalizability to routine practice, infrequent external validation, selection bias, characterization of confounding factors, ethics, and use for rare events. BDARS present opportunities to augment and extend RCTs. Preliminary modeling using single- and muti-institutional BDARS may lead to better design and less cost. Standardizations in data elements, clinical processes, and nomenclatures used to decrease variability and increase veracity needed for automation and multi-institutional data pooling in BDARS also support ability to add clinical validation phases to clinical trial design and increase participation. However, volume and variety in BDARS present other technical, policy, and conceptual challenges including applicable statistical concepts, cloud-based technologies. In this summary, we will examine both the opportunities and the challenges for use of big data in design of clinical trials. PMID:28913177

Big Data in Designing Clinical Trials: Opportunities and Challenges.

PubMed

Mayo, Charles S; Matuszak, Martha M; Schipper, Matthew J; Jolly, Shruti; Hayman, James A; Ten Haken, Randall K

2017-01-01

Emergence of big data analytics resource systems (BDARSs) as a part of routine practice in Radiation Oncology is on the horizon. Gradually, individual researchers, vendors, and professional societies are leading initiatives to create and demonstrate use of automated systems. What are the implications for design of clinical trials, as these systems emerge? Gold standard, randomized controlled trials (RCTs) have high internal validity for the patients and settings fitting constraints of the trial, but also have limitations including: reproducibility, generalizability to routine practice, infrequent external validation, selection bias, characterization of confounding factors, ethics, and use for rare events. BDARS present opportunities to augment and extend RCTs. Preliminary modeling using single- and muti-institutional BDARS may lead to better design and less cost. Standardizations in data elements, clinical processes, and nomenclatures used to decrease variability and increase veracity needed for automation and multi-institutional data pooling in BDARS also support ability to add clinical validation phases to clinical trial design and increase participation. However, volume and variety in BDARS present other technical, policy, and conceptual challenges including applicable statistical concepts, cloud-based technologies. In this summary, we will examine both the opportunities and the challenges for use of big data in design of clinical trials.

Automatic detection of protected health information from clinic narratives.

PubMed

Yang, Hui; Garibaldi, Jonathan M

2015-12-01

This paper presents a natural language processing (NLP) system that was designed to participate in the 2014 i2b2 de-identification challenge. The challenge task aims to identify and classify seven main Protected Health Information (PHI) categories and 25 associated sub-categories. A hybrid model was proposed which combines machine learning techniques with keyword-based and rule-based approaches to deal with the complexity inherent in PHI categories. Our proposed approaches exploit a rich set of linguistic features, both syntactic and word surface-oriented, which are further enriched by task-specific features and regular expression template patterns to characterize the semantics of various PHI categories. Our system achieved promising accuracy on the challenge test data with an overall micro-averaged F-measure of 93.6%, which was the winner of this de-identification challenge. Copyright © 2015 Elsevier Inc. All rights reserved.

Progress and challenges associated with halal authentication of consumer packaged goods.

PubMed

Premanandh, Jagadeesan; Bin Salem, Samara

2017-11-01

Abusive business practices are increasingly evident in consumer packaged goods. Although consumers have the right to protect themselves against such practices, rapid urbanization and industrialization result in greater distances between producers and consumers, raising serious concerns on the supply chain. The operational complexities surrounding halal authentication pose serious challenges on the integrity of consumer packaged goods. This article attempts to address the progress and challenges associated with halal authentication. Advancement and concerns on the application of new, rapid analytical methods for halal authentication are discussed. The significance of zero tolerance policy in consumer packaged foods and its impact on analytical testing are presented. The role of halal assurance systems and their challenges are also considered. In conclusion, consensus on the establishment of one standard approach coupled with a sound traceability system and constant monitoring would certainly improve and ensure halalness of consumer packaged goods. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

300-Watt Power Source Development at the Jet Propulsion Laboratory

NASA Technical Reports Server (NTRS)

Valdez, Thomas I.

2005-01-01

This viewgraph presentation reviews the JPL program to develop a 300 Watt direct methanol fuel cell. The immediate use of the fuel cell is to power test instrumentation on armored vehicles. It reviews the challenges, the system design and the system demonstration.

MOD control center automated information systems security evolution

NASA Technical Reports Server (NTRS)

Owen, Rich

1991-01-01

The role of the technology infusion process in future Control Center Automated Information Systems (AIS) is highlighted. The following subject areas are presented in the form of the viewgraphs: goals, background, threat, MOD's AISS program, TQM, SDLC integration, payback, future challenges, and bottom line.

A systems framework for identifying candidate microbial assemblages for disease management

USDA-ARS?s Scientific Manuscript database

Network models of soil and plant microbiomes present new opportunities for enhancing disease management, but also challenges for interpretation. We present a framework for interpreting microbiome networks, illustrating how the observed structure of networks can be used to generate testable hypothese...

The 2014 Sandia Verification and Validation Challenge: Problem statement

DOE PAGES

Hu, Kenneth; Orient, George

2016-01-18

This paper presents a case study in utilizing information from experiments, models, and verification and validation (V&V) to support a decision. It consists of a simple system with data and models provided, plus a safety requirement to assess. The goal is to pose a problem that is flexible enough to allow challengers to demonstrate a variety of approaches, but constrained enough to focus attention on a theme. This was accomplished by providing a good deal of background information in addition to the data, models, and code, but directing the participants' activities with specific deliverables. In this challenge, the theme ismore » how to gather and present evidence about the quality of model predictions, in order to support a decision. This case study formed the basis of the 2014 Sandia V&V Challenge Workshop and this resulting special edition of the ASME Journal of Verification, Validation, and Uncertainty Quantification.« less

Diagnosis of systemic lupus erythematosus in an unusual presentation: what a primary care physician should know.

PubMed

Pramanik, Bimalendu

2014-01-01

Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease affecting millions of people worldwide. It can affect any organ systems of the body. However, all systems may not be involved initially rather than they may be affected gradually, sometimes over years. Diagnosis depends on characteristic clinical features and laboratory test results. Some features such as skin rash, joint symptoms and oral ulcers are common in SLE. But initial presentation of many patients is unusual because either they do not have these common features of the disease or the presentation mimics other illnesses. As a result, delayed diagnosis and misdiagnosis are common. Therefore, high index of initial suspicion of SLE is critical. In clinical practice, SLE should be suspected in any patient presenting with an unexplained disease process involving two or more organ systems. To make a diagnosis in an unusual presentation, thorough clinical evaluation with details history of both present and past illnesses as well as laboratory tests for SLE should be performed. Usually primary-care physicians first evaluate SLE patients; but there is no single article, where all the information on when to suspect SLE in an unusual presentation, is available in an integrated form. In this article, a list of conditions, when SLE should be suspected in an unusual presentation, has been given and some relatively common areas with diagnostic challenges of SLE have been briefly described. To prepare this manuscript, most articles have been identified through 'Pubmed' search using keywords-atypical/ unusual presentation of SLE, case reports on SLE, gastrointestinal manifestations of SLE, neuropsychiatric SLE, diagnostic challenges with SLE, etc. Selected most articles are from currently medline-indexed journals.

Integrated Data Modeling and Simulation on the Joint Polar Satellite System Program

NASA Technical Reports Server (NTRS)

Roberts, Christopher J.; Boyce, Leslye; Smith, Gary; Li, Angela; Barrett, Larry

2012-01-01

The Joint Polar Satellite System is a modern, large-scale, complex, multi-mission aerospace program, and presents a variety of design, testing and operational challenges due to: (1) System Scope: multi-mission coordination, role, responsibility and accountability challenges stemming from porous/ill-defined system and organizational boundaries (including foreign policy interactions) (2) Degree of Concurrency: design, implementation, integration, verification and operation occurring simultaneously, at multiple scales in the system hierarchy (3) Multi-Decadal Lifecycle: technical obsolesce, reliability and sustainment concerns, including those related to organizational and industrial base. Additionally, these systems tend to become embedded in the broader societal infrastructure, resulting in new system stakeholders with perhaps different preferences (4) Barriers to Effective Communications: process and cultural issues that emerge due to geographic dispersion and as one spans boundaries including gov./contractor, NASA/Other USG, and international relationships.

Introduction to State Estimation of High-Rate System Dynamics

PubMed Central

Dodson, Jacob; Joyce, Bryan

2018-01-01

Engineering systems experiencing high-rate dynamic events, including airbags, debris detection, and active blast protection systems, could benefit from real-time observability for enhanced performance. However, the task of high-rate state estimation is challenging, in particular for real-time applications where the rate of the observer’s convergence needs to be in the microsecond range. This paper identifies the challenges of state estimation of high-rate systems and discusses the fundamental characteristics of high-rate systems. A survey of applications and methods for estimators that have the potential to produce accurate estimations for a complex system experiencing highly dynamic events is presented. It is argued that adaptive observers are important to this research. In particular, adaptive data-driven observers are advantageous due to their adaptability and lack of dependence on the system model. PMID:29342855

The Emergence and Challenging Growth of the Bio-Ethanol Innovation System in Taiwan (1949-2015).

PubMed

Chung, Chao-Chen; Yang, Siang-Cing

2016-02-19

This study explores the bio-ethanol innovation system in Taiwan from the perspective of a technology innovation system (TIS). Taiwan is a newly industrialized country and is not currently a main producer of bio-ethanol. This study analyzes the evolution of bio-ethanol innovation system in Taiwan and places a particular emphasis on challenges that present policies face in the context of potential long-term bio-ethanol development. Through an evaluation of the consistency of the present research, technology, development and innovation (RTDI) policies as well as the influence of these policies on the functional dynamics of bio-ethanol innovation system, mechanisms prohibiting the system from flourishing are determined. It is suggested that the production of bio-ethanol in Taiwan would be achieved if the government: (1) fixes long-term targets for both domestic bio-ethanol development and emission reduction; and (2) comprehensively designs a set of interrelated RTDI policies in accordance with the functional pattern of the bio-ethanol innovation system and consistently implements these policies. If such measures were implemented, it is considered that the bio-ethanol innovation system in Taiwan would flourish.

Cleared for Launch - Lessons Learned from the OSIRIS-REx System Requirements Verification Program

NASA Technical Reports Server (NTRS)

Stevens, Craig; Adams, Angela; Williams, Bradley; Goodloe, Colby

2017-01-01

Requirements verification of a large flight system is a challenge. It is especially challenging for engineers taking on their first role in space systems engineering. This paper describes our approach to verification of the Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer (OSIRIS-REx) system requirements. It also captures lessons learned along the way from developing systems engineers embroiled in this process. We begin with an overview of the mission and science objectives as well as the project requirements verification program strategy. A description of the requirements flow down is presented including our implementation for managing the thousands of program and element level requirements and associated verification data. We discuss both successes and methods to improve the managing of this data across multiple organizational interfaces. Our approach to verifying system requirements at multiple levels of assembly is presented using examples from our work at instrument, spacecraft, and ground segment levels. We include a discussion of system end-to-end testing limitations and their impacts to the verification program. Finally, we describe lessons learned that are applicable to all emerging space systems engineers using our unique perspectives across multiple organizations of a large NASA program.

The Emergence and Challenging Growth of the Bio-Ethanol Innovation System in Taiwan (1949–2015)

PubMed Central

Chung, Chao-Chen; Yang, Siang-Cing

2016-01-01

This study explores the bio-ethanol innovation system in Taiwan from the perspective of a technology innovation system (TIS). Taiwan is a newly industrialized country and is not currently a main producer of bio-ethanol. This study analyzes the evolution of bio-ethanol innovation system in Taiwan and places a particular emphasis on challenges that present policies face in the context of potential long-term bio-ethanol development. Through an evaluation of the consistency of the present research, technology, development and innovation (RTDI) policies as well as the influence of these policies on the functional dynamics of bio-ethanol innovation system, mechanisms prohibiting the system from flourishing are determined. It is suggested that the production of bio-ethanol in Taiwan would be achieved if the government: (1) fixes long-term targets for both domestic bio-ethanol development and emission reduction; and (2) comprehensively designs a set of interrelated RTDI policies in accordance with the functional pattern of the bio-ethanol innovation system and consistently implements these policies. If such measures were implemented, it is considered that the bio-ethanol innovation system in Taiwan would flourish. PMID:26907306

Challenges And Concepts for Design of An Interaction Region With Push-Pull Arrangement of Detectors - An Interface Document

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parker, B.; /Brookhaven; Herve, Alain

2011-10-14

Two experimental detectors working in a push-pull mode has been considered for the Interaction Region of the International Linear Collider. The push-pull mode of operation sets specific requirements and challenges for many systems of detector and machine, in particular for the IR magnets, for the cryogenics and alignment system, for beamline shielding, for detector design and overall integration, and so on. These challenges and the identified conceptual solutions discussed in the paper intend to form a draft of the Interface Document which will be developed further in the nearest future. The authors of the present paper include the organizers andmore » conveners of working groups of the workshop on engineering design of interaction region IRENG07, the leaders of the IR Integration within Global Design Effort Beam Delivery System, and the representatives from each detector concept submitting the Letters Of Intent.« less

Towards agile large-scale predictive modelling in drug discovery with flow-based programming design principles.

PubMed

Lampa, Samuel; Alvarsson, Jonathan; Spjuth, Ola

2016-01-01

Predictive modelling in drug discovery is challenging to automate as it often contains multiple analysis steps and might involve cross-validation and parameter tuning that create complex dependencies between tasks. With large-scale data or when using computationally demanding modelling methods, e-infrastructures such as high-performance or cloud computing are required, adding to the existing challenges of fault-tolerant automation. Workflow management systems can aid in many of these challenges, but the currently available systems are lacking in the functionality needed to enable agile and flexible predictive modelling. We here present an approach inspired by elements of the flow-based programming paradigm, implemented as an extension of the Luigi system which we name SciLuigi. We also discuss the experiences from using the approach when modelling a large set of biochemical interactions using a shared computer cluster.Graphical abstract.

Challenges, issues and trends in fall detection systems

PubMed Central

2013-01-01

Since falls are a major public health problem among older people, the number of systems aimed at detecting them has increased dramatically over recent years. This work presents an extensive literature review of fall detection systems, including comparisons among various kinds of studies. It aims to serve as a reference for both clinicians and biomedical engineers planning or conducting field investigations. Challenges, issues and trends in fall detection have been identified after the reviewing work. The number of studies using context-aware techniques is still increasing but there is a new trend towards the integration of fall detection into smartphones as well as the use of machine learning methods in the detection algorithm. We have also identified challenges regarding performance under real-life conditions, usability, and user acceptance as well as issues related to power consumption, real-time operations, sensing limitations, privacy and record of real-life falls. PMID:23829390

Meeting the challenges of the digital medical enterprise of the future by reusing enterprise software components

NASA Astrophysics Data System (ADS)

Shani, Uri; Kol, Tomer; Shachor, Gal

2004-04-01

Managing medical digital information objects, and in particular medical images is an enterprise-grade problem. Firstly, there is the sheer amount of digital data that is generated in the proliferation of digital (and film-free) medical imaging. Secondly, the managing software ought to enjoy high availability, recoverability and manageability that are found only in the most business-critical systems. Indeed, such requirements are borrowed from the business enterprise world. Moreover, the solution for the medical information management problem should too employ the same software tools, middlewares and architectures. It is safe to say that all first-line medical PACS products strive to provide a solution for all these challenging requirements. The DICOM standard has been a prime enabler of such solutions. DICOM created the interconnectivity, which made it possible for a PACS service to manage millions of exams consisting of trillions of images. With the more comprehensive IHE architecture, the enterprise is expanded into a multi-facility regional conglomerate, which presents extreme demands from the data management system. HIPPA legislations add considerable challenges per security, privacy and other legal issues, which aggravate the situation. In this paper, we firstly present what in our view should be the general requirements for a first-line medical PACS, taken from an enterprise medical imaging storage and management solution perspective. While these requirements can be met by homegrown implementations, we suggest looking at the existing technologies, which have emerged in the recent years to meet exactly these challenges in the business world. We present an evolutionary process, which led to the design and implementation of a medical object management subsystem. This is indeed an enterprise medical imaging solution that is built upon respective technological components. The system answers all these challenges simply by not reinventing wheels, but rather reusing the best "wheels" for the job. Relying on such middleware components allowed us to concentrate on added value for this specific problem domain.

Recent trends for practical rehabilitation robotics, current challenges and the future.

PubMed

Yakub, Fitri; Md Khudzari, Ahmad Zahran; Mori, Yasuchika

2014-03-01

This paper presents and studies various selected literature primarily from conference proceedings, journals and clinical tests of the robotic, mechatronics, neurology and biomedical engineering of rehabilitation robotic systems. The present paper focuses of three main categories: types of rehabilitation robots, key technologies with current issues and future challenges. Literature on fundamental research with some examples from commercialized robots and new robot development projects related to rehabilitation are introduced. Most of the commercialized robots presented in this paper are well known especially to robotics engineers and scholars in the robotic field, but are less known to humanities scholars. The field of rehabilitation robot research is expanding; in light of this, some of the current issues and future challenges in rehabilitation robot engineering are recalled, examined and clarified with future directions. This paper is concluded with some recommendations with respect to rehabilitation robots.

MRI of the Musculoskeletal System: Advanced Applications using High and Ultrahigh Field MRI.

PubMed

Alizai, Hamza; Chang, Gregory; Regatte, Ravinder R

2015-09-01

In vivo MRI has revolutionized the diagnosis and treatment of musculoskeletal disorders over the past 3 decades. Traditionally performed at 1.5 T, MRI at higher field strengths offers several advantages over lower field strengths including increased signal-to-noise ratio, higher spatial resolution, improved spectral resolution for spectroscopy, improved sensitivity for X-nucleus imaging, and decreased image acquisition times. However, the physics of imaging at higher field strengths also presents technical challenges. These include B0 and B1+ field inhomogeneity, design and construction of dedicated radiofrequency (RF) coils for use at high field, increased chemical shift and susceptibility artifacts, increased RF energy deposition (specific absorption rate), increased metal artifacts, and changes in relaxation times compared with the lower field scanners. These challenges were overcome in optimizing high-field (HF) (3 T) MRI over a decade ago. HF MRI systems have since gained universal acceptance for clinical musculoskeletal imaging and have also been widely utilized for the study of musculoskeletal anatomy and physiology. Recently there has been an increasing interest in exploring musculoskeletal applications of ultrahigh field (UHF) (7 T) systems. However, technical challenges similar to those encountered when moving from 1.5 T to 3 T have to be overcome to optimize 7 T musculoskeletal imaging. In this narrative review, we discuss the many potential opportunities and technical challenges presented by the HF and UHF MRI systems. We highlight recent developments in in vivo imaging of musculoskeletal tissues that benefit most from HF imaging including cartilage, skeletal muscle, and bone. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Green Propulsion Technologies for Advanced Air Transports

NASA Technical Reports Server (NTRS)

Del Rosario, Ruben

2015-01-01

Air transportation is critical to U.S. and Global economic vitality. However, energy and climate issues challenge aviations ability to be sustainable in the long term. Aviation must dramatically reduce fuel use and related emissions. Energy costs to U.S. airlines nearly tripled between 1995 and 2011, and continue to be the highest percentage of operating costs. The NASA Advanced Air Transports Technology Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advanced technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. The presentation will highlight the NASA vision of revolutionary systems and propulsion technologies needed to achieve these challenging goals. Specifically, the primary focus is on the N+3 generation; that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe, which are envisioned as being powered by Hybrid Electric Propulsion Systems.

Challenges and Approach for Making the Top End Optical Assembly for the 4-meter Advanced Technology Solar Telescope

NASA Astrophysics Data System (ADS)

Canzian, Blaise; Barentine, J.; Hull, T.

2012-01-01

L-3 Integrated Optical Systems (IOS) Division has been selected by the National Solar Observatory (NSO) to make the Top End Optical Assembly (TEOA) for the 4-meter Advanced Technology Solar Telescope (ATST) to operate at Haleakala, Maui. ATST will perform to a very high optical performance level in a difficult thermal environment. The TEOA, containing the 0.65-meter silicon carbide secondary mirror and support, mirror thermal management system, mirror positioning and fast tip-tilt system, field stop with thermally managed heat dump, thermally managed Lyot stop, safety interlock and control system, and support frame, operates in the "hot spot” at the prime focus of the ATST and so presents special challenges. In this paper, we will describe the L-3 IOS technical approach to meet these challenges, including subsystems for opto-mechanical positioning, rejected and stray light control, wavefront tip-tilt compensation, and thermal management. Key words: ATST, TEOA, L-3 IOS, thermal management, silicon carbide (SiC) mirrors, hexapods, solar astronomy

A voyage to Mars: A challenge to collaboration between man and machines

NASA Technical Reports Server (NTRS)

Statler, Irving C.

1991-01-01

A speech addressing the design of man machine systems for exploration of space beyond Earth orbit from the human factors perspective is presented. Concerns relative to the design of automated and intelligent systems for the NASA Space Exploration Initiative (SEI) missions are largely based on experiences with integrating humans and comparable systems in aviation. The history, present status, and future prospect, of human factors in machine design are discussed in relation to a manned voyage to Mars. Three different cases for design philosophy are presented. The use of simulation is discussed. Recommendations for required research are given.

Does the Field of EBD Need a Distinct Set of "Intensive" Interventions or More Systemic Intensity within a Continuum of Social/Emotional Supports?

ERIC Educational Resources Information Center

Lewis, Timothy J.

2016-01-01

The challenges of educating children and youth with intensive social, emotional, and academic needs have been well documented. Students with emotional/ behavioral disorders (EBD) present a range of daily challenges from low intensity, high frequency chronic behaviors such as poor school attendance, disrespect addressed to adults and peers,…

WFIRST: Exoplanet Data Challenge. Atmospheric retrieval results

NASA Astrophysics Data System (ADS)

Hildebrandt, Sergi; Turnbull, Margaret; Exoplanet Data Challenge Team

2018-01-01

We present the results of the Exoplanet Data Challenge for its first 2016/17 cycle and the current cycle 2. Some input spectra for extra-solar systems are processed through the WFIRST IFS instrument model, producing simulated data representative of the flight data. Atmospheric properties are then recovered using complex atmospheric models and multidimensional optimization. The results inform about WFIRST CGI ability to characterize exo-planetray atmospheres.

Current Status and Future Challenges in Risk-Based Radiation Engineering

NASA Technical Reports Server (NTRS)

Pellish, Jonathan A.

2017-01-01

This presentation covers the basis and challenges for radiation effects in electronic systems. The three main types of radiation effects in electronics are: 1) total ionizing dose (TID), 2) total non-ionizing dose (TNID) / displacement damage dose (DDD), and 3) single-event effect (SEE). Some content on relevant examples of effects, current concerns, and possible environmental model-driven solutions are also included.

Canes Implementation: Analysis of Budgetary, Business, and Policy Challenges

DTIC Science & Technology

2014-12-01

Concept of Operations COTS Commercial Off the Shelf DAG Defense Acquisitions Guidebook DAS Defense Acquisitions System DOD Department of Defense...and Integration NSS National Security Strategy OA Open Architecture OCO Overseas Contingency Operations OEF Operation Enduring Freedom OIF...and software and civilian-type open architecture ( OA ) presents a series of challenges. The purpose of this report is to provide the Navy with a

"Did You Pay Your Taxes?" How (Not) to Conduct Tax Evasion Surveys in Transition Countries

ERIC Educational Resources Information Center

Gerxhani, Klarita

2007-01-01

Gathering large-scale data on tax evasion is an undisputable challenge in and of itself. Doing so in a country in transition from a communist to a democratic system is even more difficult. This paper discusses the challenges and presents a case study to show how they can be dealt with effectively. One important implication of the paper is that…

Sample Returns Missions in the Coming Decade

NASA Technical Reports Server (NTRS)

Desai, Prasun N.; Mitcheltree, Robert A.; Cheatwood, F. McNeil

2000-01-01

In the coming decade, several missions will attempt to return samples to Earth from varying parts of the solar system. These samples will provide invaluable insight into the conditions present during the early formation of the solar system, and possibly give clues to how life began on Earth. A description of five sample return missions is presented (Stardust, Genesis, Muses-C. Mars Sample Return, and Comet Nucleus Sample Return). An overview of each sample return mission is given, concentrating particularly on the technical challenges posed during the Earth entry, descent, and landing phase of the missions. Each mission faces unique challenges in the design of an Earth entry capsule. The design of the entry capsule must address the aerodynamic, heating, deceleration, landing, and recovery requirements for the safe return of samples to Earth.

Managing laboratory automation in a changing pharmaceutical industry

PubMed Central

Rutherford, Michael L.

1995-01-01

The health care reform movement in the USA and increased requirements by regulatory agencies continue to have a major impact on the pharmaceutical industry and the laboratory. Laboratory management is expected to improve effciency by providing more analytical results at a lower cost, increasing customer service, reducing cycle time, while ensuring accurate results and more effective use of their staff. To achieve these expectations, many laboratories are using robotics and automated work stations. Establishing automated systems presents many challenges for laboratory management, including project and hardware selection, budget justification, implementation, validation, training, and support. To address these management challenges, the rationale for project selection and implementation, the obstacles encountered, project outcome, and learning points for several automated systems recently implemented in the Quality Control Laboratories at Eli Lilly are presented. PMID:18925014

Present status of the KISS project

NASA Astrophysics Data System (ADS)

Miyatake, H.; Wada, M.; Watanabe, X. Y.; Hirayama, Y.; Schury, P.; Ahmed, M.; Ishiyama, H.; Jeong, S. C.; Kakiguchi, Y.; Kimura, S.; Moon, J. Y.; Mukai, M.; Oyaizu, M.; Park, J. H.

2018-04-01

KISS project aims at finding an astrophysical condition for synthesizing r-process heavy element isotopes, which are characterized as the third peak in the solar abundance pattern. This is an experimental challenge in nuclear physics to measure ground and isomeric state properties of unknown nuclei around the region of N=126 isotones. So far we have constructed and developed new type of mass separation system, KISS (KEK Isotope Separation System) and performed measurements of lifetimes and hyperfine structures of some platinum and iridium neutron-rich radioactive isotopes by applying multi-nucleon transfer reactions and in-gas laser ionization and spectroscopy (IGLIS) methods. In this report, recent physics results, updated KISS performance, and future's research plan including a challenge of a systematic mass measurement with MRTOF (Multi-Reflection Time-Of-Flight mass spectrograph) are presented.

In Situ Fabrication Technologies: Meeting the Challenge for Exploration

NASA Technical Reports Server (NTRS)

Howard, Richard W.

2005-01-01

A viewgraph presentation on Lunar and Martian in situ fabrication technologies meeting the challenges for exploration is shown. The topics include: 1) Exploration Vision; 2) Vision Requirements Early in the Program; 3) Vision Requirements Today; 4) Why is ISFR Technology Needed? 5) ISFR and In Situ Resource Utilization (ISRU); 6) Fabrication Feedstock Considerations; 7) Planetary Resource Primer; 8) Average Chemical Element Abundances in Lunar Soil; 9) Chemical Elements in Aerospace Engineering Materials; 10) Schematic of Raw Regolith Processing into Constituent Components; 11) Iron, Aluminum, and Basalt Processing from Separated Elements and Compounds; 12) Space Power Systems; 13) Power Source Applicability; 14) Fabrication Systems Technologies; 15) Repair and Nondestructive Evaluation (NDE); and 16) Habitat Structures. A development overview of Lunar and Martian repair and nondestructive evaluation is also presented.

Spotlight on VET Denmark

ERIC Educational Resources Information Center

Cedefop - European Centre for the Development of Vocational Training, 2012

2012-01-01

This paper presents data on the vocational education and training (VET) in Denmark. VET plays a key role in the Danish strategy for lifelong learning and meeting the challenges of globalisation and technological change. The Danish education and training system comprises a mainstream system providing qualifications at all levels, from compulsory…

Readiness of food composition databases and food component analysis systems for nutrigenomics

USDA-ARS?s Scientific Manuscript database

The study objective was to discuss the international implications of using nutrigenomics as the basis for individualized health promotion and chronic disease prevention and the challenges it presents to existing nutrient databases and nutrient analysis systems. Definitions and research methods of nu...

Evaluation of a variable speed limit system for wet and extreme weather conditions : phase 1 report.

DOT National Transportation Integrated Search

2012-06-01

Weather presents considerable challenges to the highway system, both in terms of safety and operations. From a safety standpoint, weather (i.e. precipitation in the form of rain, snow or ice) reduces pavement friction, thus increasing the potential f...

Research Challenges in Water Infrastructure Condition Assessment, Rehabilitation and System Optimization – The U.S. Perspective

EPA Science Inventory

This presentation first provides an overview of U.S.EPA research activities on water infrastructure condition assessment, system rehabilitation, and asset management. It then describes in detail specific activities in pipe leak detection, water conservation and the advanced wate...

Role of future scenarios in understanding deep uncertainty in long-term air quality management

EPA Science Inventory

The environment and its interactions with human systems, whether economic, social or political, are complex. Relevant drivers may disrupt system dynamics in unforeseen ways, making it difficult to predict future conditions. This kind of deep uncertainty presents a challenge to ...

Practical Application of Model-based Programming and State-based Architecture to Space Missions

NASA Technical Reports Server (NTRS)

Horvath, Gregory A.; Ingham, Michel D.; Chung, Seung; Martin, Oliver; Williams, Brian

2006-01-01

Innovative systems and software engineering solutions are required to meet the increasingly challenging demands of deep-space robotic missions. While recent advances in the development of an integrated systems and software engineering approach have begun to address some of these issues, they are still at the core highly manual and, therefore, error-prone. This paper describes a task aimed at infusing MIT's model-based executive, Titan, into JPL's Mission Data System (MDS), a unified state-based architecture, systems engineering process, and supporting software framework. Results of the task are presented, including a discussion of the benefits and challenges associated with integrating mature model-based programming techniques and technologies into a rigorously-defined domain specific architecture.

Integrating Grid Services into the Cray XT4 Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

NERSC; Cholia, Shreyas; Lin, Hwa-Chun Wendy

2009-05-01

The 38640 core Cray XT4"Franklin" system at the National Energy Research Scientific Computing Center (NERSC) is a massively parallel resource available to Department of Energy researchers that also provides on-demand grid computing to the Open Science Grid. The integration of grid services on Franklin presented various challenges, including fundamental differences between the interactive and compute nodes, a stripped down compute-node operating system without dynamic library support, a shared-root environment and idiosyncratic application launching. Inour work, we describe how we resolved these challenges on a running, general-purpose production system to provide on-demand compute, storage, accounting and monitoring services through generic gridmore » interfaces that mask the underlying system-specific details for the end user.« less

Publishing and Editing of Semantically-Enabled Scientific Metadata Across Multiple Web Platforms: Challenges and Experiences

NASA Astrophysics Data System (ADS)

Patton, E. W.; West, P.; Greer, R.; Jin, B.

2011-12-01

Following on work presented at the 2010 AGU Fall Meeting, we present a number of real-world collections of semantically-enabled scientific metadata ingested into the Tetherless World RDF2HTML system as structured data and presented and edited using that system. Two separate datasets from two different domains (oceanography and solar sciences) are made available using existing web standards and services, e.g. encoded using ontologies represented with the Web Ontology Language (OWL) and stored in a SPARQL endpoint for querying. These datasets are deployed for use in three different web environments, i.e. Drupal, MediaWiki, and a custom web portal written in Java, to highlight the cross-platform nature of the data presentation. Stylesheets used to transform concepts in each domain as well as shared terms into HTML will be presented to show the power of using common ontologies to publish data and support reuse of existing terminologies. In addition, a single domain dataset is shared between two separate portal instances to demonstrate the ability for this system to offer distributed access and modification of content across the Internet. Lastly, we will highlight challenges that arose in the software engineering process, outline the design choices we made in solving those issues, and discuss how future improvements to this and other systems will enable the evolution of distributed, decentralized collaborations for scientific data sharing across multiple research groups.

Robotics for Nuclear Material Handling at LANL:Capabilities and Needs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harden, Troy A; Lloyd, Jane A; Turner, Cameron J

Nuclear material processing operations present numerous challenges for effective automation. Confined spaces, hazardous materials and processes, particulate contamination, radiation sources, and corrosive chemical operations are but a few of the significant hazards. However, automated systems represent a significant safety advance when deployed in place of manual tasks performed by human workers. The replacement of manual operations with automated systems has been desirable for nearly 40 years, yet only recently are automated systems becoming increasingly common for nuclear materials handling applications. This paper reviews several automation systems which are deployed or about to be deployed at Los Alamos National Laboratory formore » nuclear material handling operations. Highlighted are the current social and technological challenges faced in deploying automated systems into hazardous material handling environments and the opportunities for future innovations.« less

The challenges facing wearable sensor systems.

PubMed

McAdams, Eric; Gehin, Claudine; Massot, Bertrand; McLaughlin, James

2012-01-01

It has been pointed out that, in spite of significant national and international funding programmes, there is a dearth of successfully commercialised wearable monitoring systems. Although problems such as financial reimbursement, device interoperability and the present lack of the required connected healthcare infrastructure are major hurdles to the provision of remote clinical monitoring of home-based patients, the "Mount Everest" of monitoring applications, why are wearable systems not already commercialised and used in less demanding applications? The numerous wearable systems which appear on the Web and even in the literature are, for the most part, basic prototypes unsuited to the demands of real-life applications. SMEs which do seek to commercialise clinically promising systems are unfortunately faced with many challenges and few as yet have survived long enough to successfully commercialise their innovations.

Pharmaceutical policies in a crisis? Challenges and solutions identified at the PPRI Conference.

PubMed

Vogler, Sabine; Zimmermann, Nina; Ferrario, Alessandra; Wirtz, Veronika J; de Joncheere, Kees; Pedersen, Hanne Bak; Dedet, Guillaume; Paris, Valérie; Mantel-Teeuwisse, Aukje K; Babar, Zaheer-Ud-Din

2016-01-01

In October 2015, the third international Pharmaceutical Pricing and Reimbursement Information (PPRI) Conference was held in Vienna to foster discussion on challenges in pricing and reimbursement policies for medicines. The research presented highlighted that commonly used pharmaceutical pricing and reimbursement policies are not sufficiently effective to address current challenges. Conference participants called for fundamental reforms to ensure access to medicines, particularly to new and potentially more effective and/or safe medicines, while safeguarding the financial sustainability of health systems and working towards universal health coverage.

Fostering outcomes through education: a systems approach to collaboration and creativity.

PubMed

Smith, Elaine L

2014-04-01

Across the country, integrated health care systems continue to emerge and expand. Large multifacility organizations can present both challenges and opportunities for nursing professional development and continuing education activities. This article will explore how one large multifacility system is addressing the varied learning needs of nursing staff across the enterprise. Copyright 2014, SLACK Incorporated.

From Requirements to Code: Issues and Learning in IS Students' Systems Development Projects

ERIC Educational Resources Information Center

Scott, Elsje

2008-01-01

The Computing Curricula (2005) place Information Systems (IS) at the intersection of exact sciences (e.g. General Systems Theory), technology (e.g. Computer Science), and behavioral sciences (e.g. Sociology). This presents particular challenges for teaching and learning, as future IS professionals need to be equipped with a wide range of…

Development of an Electronic Nose Sensing Platform for Undergraduate Education in Nanotechnology

ERIC Educational Resources Information Center

Russo, Daniel V.; Burek, Michael J.; Iutzi, Ryan M.; Mracek, James A.; Hesjedal, Thorsten

2011-01-01

The teaching of the different aspects of a sensor system, with a focus on the involved nanotechnology, is a challenging, yet important task. We present the development of an electronic nose system that utilizes a nanoscale amperometric sensing mechanism for gas mixtures. The fabrication of the system makes use of a basic microfabrication facility,…

Examining fire-prone forest landscapes as coupled human and natural systems

Treesearch

Thomas A. Spies; Eric M. White; Jeffrey D. Kline; A. Paige Fisher; Alan Ager; John Bailey; John Bolte; Jennifer Koch; Emily Platt; Christine S. Olsen; Derric Jacobs; Bruce Shindler; Michelle M. Steen-Adams; Roger Hammer

2014-01-01

Fire-prone landscapes are not well studied as coupled human and natural systems (CHANS) and present many challenges for understanding and promoting adaptive behaviors and institutions. Here, we explore how heterogeneity, feedbacks, and external drivers in this type of natural hazard system can lead to complexity and can limit the development of more adaptive approaches...

Readout systems for inner detectors at the LHC and SLHC

NASA Astrophysics Data System (ADS)

Issever, Cigdem

2006-12-01

A general overview of the optoelectronic readout and control systems of the ATLAS and CMS inner detectors is given. The talk will also cover challenges and issues of future optoelectronic readout systems at the upgraded LHC (SLHC). First results of radiation tests of VCSELs and optical fibres which were irradiated up to SLHC fluences will be presented.

Evaluating Health Advice in a Web 2.0 Environment: The Impact of Multiple User-Generated Factors on HIV Advice Perceptions.

PubMed

Walther, Joseph B; Jang, Jeong-Woo; Hanna Edwards, Ashley A

2018-01-01

Unlike traditional media, social media systems often present information of different types from different kinds of contributors within a single message pane, a juxtaposition of potential influences that challenges traditional health communication processing. One type of social media system, question-and-answer advice systems, provides peers' answers to health-related questions, which yet other peers read and rate. Responses may appear good or bad, responders may claim expertise, and others' aggregated evaluations of an answer's usefulness may affect readers' judgments. An experiment explored how answer feasibility, expertise claims, and user-generated ratings affected readers' assessments of advice about anonymous HIV testing. Results extend the heuristic-systematic model of persuasion (Chaiken, 1980) and warranting theory (Walther & Parks, 2002). Information that is generally associated with both systematic and heuristic processes influenced readers' evaluations. Moreover, content-level cues affected judgments about message sources unexpectedly. When conflicting cues were present, cues with greater warranting value (consensus user-generated ratings) had greater influence on outcomes than less warranted cues (self-promoted expertise). Findings present a challenge to health professionals' concerns about the reliability of online health information systems.

Subacute Hypophysitis with Panhypopituitarism as First Presentation of HIV and Syphilis Coinfection.

PubMed

Alves, Rute; França, Margarida

2017-01-01

Infection by Treponema pallidum still represents a clinical challenge due to its various forms of presentation. HIV coinfection added diversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis and panhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient.

The next generation of command post computing

NASA Astrophysics Data System (ADS)

Arnold, Ross D.; Lieb, Aaron J.; Samuel, Jason M.; Burger, Mitchell A.

2015-05-01

The future of command post computing demands an innovative new solution to address a variety of challenging operational needs. The Command Post of the Future is the Army's primary command and control decision support system, providing situational awareness and collaborative tools for tactical decision making, planning, and execution management from Corps to Company level. However, as the U.S. Army moves towards a lightweight, fully networked battalion, disconnected operations, thin client architecture and mobile computing become increasingly essential. The Command Post of the Future is not designed to support these challenges in the coming decade. Therefore, research into a hybrid blend of technologies is in progress to address these issues. This research focuses on a new command and control system utilizing the rich collaboration framework afforded by Command Post of the Future coupled with a new user interface consisting of a variety of innovative workspace designs. This new system is called Tactical Applications. This paper details a brief history of command post computing, presents the challenges facing the modern Army, and explores the concepts under consideration for Tactical Applications that meet these challenges in a variety of innovative ways.

Supply Chain Management on IBS Implementation in Klang Valley Construction Industry: Challenges and Issues

NASA Astrophysics Data System (ADS)

Azrizal Fauzi, Mohd; Hasim, Sulaiman; Awang, Anizah; Ridzuan, Ahmad Ruslan Mohd; Nur Yunus, Juzailah

2017-12-01

Industrialized Building System (IBS) is a system where the components of the building are manufactured in a factory and it will be transported to the site to form the structures. The supply chain management (SCM) is a system where the delivery flows of the IBS products from manufacturers to the site. The aim of this research is to identify the major challenges and to analyze the issues on IBS implementation in SCM in Klang Valley from the manufacturers perspective. The methodology used in this paper is based on primary data through questionnaire and interview. Questionnaires were sent to the Manufacturers. It can be concluded that this paper attempts to present more on the challenges and issues that those companies of manufacturers faced during their success journey in finding integration in their supply chain. The main contributions of this paper are integrating all the supply chain integration challenges and issues on IBS. Therefore, these contributions will be helpful for the organization of manufacturers and IBS players that establish the integration in their SCM.

Advanced controls for light sources

NASA Astrophysics Data System (ADS)

Biedron, S. G.; Edelen, A. L.; Milton, S. V.

2016-09-01

We present a summary of our team's recent efforts in developing adaptive, artificial intelligence-inspired techniques specifically to address several control challenges that arise in machines/systems including those in particle accelerator systems. These techniques can readily be adapted to other systems such as lasers, beamline optics, etc… We are not at all suggesting that we create an autonomous system, but create a system with an intelligent control system, that can continually use operational data to improve itself and combines both traditional and advanced techniques. We believe that the system performance and reliability can be increased based on our findings. Another related point is that the controls sub-system of an overall system is usually not the heart of the system architecture or design process. More bluntly, often times all of the peripheral systems are considered as secondary to the main system components in the architecture design process because it is assumed that the controls system will be able to "fix" challenges found later with the sub-systems for overall system operation. We will show that this is not always the case and that it took an intelligent control application to overcome a sub-system's challenges. We will provide a recent example of such a "fix" with a standard controller and with an artificial intelligence-inspired controller. A final related point to be covered is that of system adaptation for requirements not original to a system's original design.

Appdaptivity: An Internet of Things Device-Decoupled System for Portable Applications in Changing Contexts

PubMed Central

Díaz, Manuel; Rubio, Bartolomé; Van den Abeele, Floris

2018-01-01

Currently, applications in the Internet of Things (IoT) are tightly coupled to the underlying physical devices. As a consequence, upon adding a device, device replacement or user’s relocation to a different physical space, application developers have to re-perform installation and configuration processes to reconfigure applications, which bears costs in time and knowledge of low-level details. In the emerging IoT field, this issue is even more challenging due to its current unpredictable growth in term of applications and connected devices. In addition, IoT applications can be personalised to each end user and can be present in different environments. As a result, IoT scenarios are very changeable, presenting a challenge for IoT applications. In this paper we present Appdaptivity, a system that enables the development of portable device-decoupled applications that can be adapted to changing contexts. Through Appdaptivity, application developers can intuitively create portable and personalised applications, disengaging from the underlying physical infrastructure. Results confirms a good scalability of the system in terms of connected users and components involved. PMID:29701698

Appdaptivity: An Internet of Things Device-Decoupled System for Portable Applications in Changing Contexts.

PubMed

Martín, Cristian; Hoebeke, Jeroen; Rossey, Jen; Díaz, Manuel; Rubio, Bartolomé; Van den Abeele, Floris

2018-04-26

Currently, applications in the Internet of Things (IoT) are tightly coupled to the underlying physical devices. As a consequence, upon adding a device, device replacement or user’s relocation to a different physical space, application developers have to re-perform installation and configuration processes to reconfigure applications, which bears costs in time and knowledge of low-level details. In the emerging IoT field, this issue is even more challenging due to its current unpredictable growth in term of applications and connected devices. In addition, IoT applications can be personalised to each end user and can be present in different environments. As a result, IoT scenarios are very changeable, presenting a challenge for IoT applications. In this paper we present Appdaptivity, a system that enables the development of portable device-decoupled applications that can be adapted to changing contexts. Through Appdaptivity, application developers can intuitively create portable and personalised applications, disengaging from the underlying physical infrastructure. Results confirms a good scalability of the system in terms of connected users and components involved.

Development of noSQL data storage for the ATLAS PanDA Monitoring System

NASA Astrophysics Data System (ADS)

Ito, H.; Potekhin, M.; Wenaus, T.

2012-12-01

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with an R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic rate of queries. In conclusion, we present our experience with operating a Cassandra cluster over an extended period of time and with data load adequate for planned application.

Design and Control of Compliant Tensegrity Robots Through Simulation and Hardware Validation

NASA Technical Reports Server (NTRS)

Caluwaerts, Ken; Despraz, Jeremie; Iscen, Atil; Sabelhaus, Andrew P.; Bruce, Jonathan; Schrauwen, Benjamin; Sunspiral, Vytas

2014-01-01

To better understand the role of tensegrity structures in biological systems and their application to robotics, the Dynamic Tensegrity Robotics Lab at NASA Ames Research Center has developed and validated two different software environments for the analysis, simulation, and design of tensegrity robots. These tools, along with new control methodologies and the modular hardware components developed to validate them, are presented as a system for the design of actuated tensegrity structures. As evidenced from their appearance in many biological systems, tensegrity ("tensile-integrity") structures have unique physical properties which make them ideal for interaction with uncertain environments. Yet these characteristics, such as variable structural compliance, and global multi-path load distribution through the tension network, make design and control of bio-inspired tensegrity robots extremely challenging. This work presents the progress in using these two tools in tackling the design and control challenges. The results of this analysis includes multiple novel control approaches for mobility and terrain interaction of spherical tensegrity structures. The current hardware prototype of a six-bar tensegrity, code-named ReCTeR, is presented in the context of this validation.

Simulating New Drop Test Vehicles and Test Techniques for the Orion CEV Parachute Assembly System

NASA Technical Reports Server (NTRS)

Morris, Aaron L.; Fraire, Usbaldo, Jr.; Bledsoe, Kristin J.; Ray, Eric; Moore, Jim W.; Olson, Leah M.

2011-01-01

The Crew Exploration Vehicle Parachute Assembly System (CPAS) project is engaged in a multi-year design and test campaign to qualify a parachute recovery system for human use on the Orion Spacecraft. Test and simulation techniques have evolved concurrently to keep up with the demands of a challenging and complex system. The primary simulations used for preflight predictions and post-test data reconstructions are Decelerator System Simulation (DSS), Decelerator System Simulation Application (DSSA), and Drop Test Vehicle Simulation (DTV-SIM). The goal of this paper is to provide a roadmap to future programs on the test technique challenges and obstacles involved in executing a large-scale, multi-year parachute test program. A focus on flight simulation modeling and correlation to test techniques executed to obtain parachute performance parameters are presented.

Impact Challenges in Community Science-with-Practice: Lessons from PROSPER on Transformative Practitioner-Scientist Partnerships and Prevention Infrastructure Development

PubMed Central

Greenberg, Mark

2011-01-01

At present, evidence-based programs (EBPs) to reduce youth violence are failing to translate into widespread community practice, despite their potential for impact on this pervasive public health problem. In this paper we address two types of challenges in the achievement of such impact, drawing upon lessons from the implementation of a partnership model called PROSPER. First, we address five key challenges in the achievement of community-level impact through effective community planning and action: readiness and mobilization of community teams; maintaining EBP implementation quality; sustaining community teams and EBPs; demonstrating community-level impact; and continuous, proactive technical assistance. Second, we consider grand challenges in the large-scale translation of EBPs: (1) building, linking and expanding existing infrastructures to support effective EBP delivery systems, and (2) organizing networks of practitioner-scientist partnerships—networks designed to integrate diffusion of EBPs with research that examines effective strategies to do so. The PROSPER partnership model is an evidence-based delivery system for community-based prevention and has evolved through two decades of NIH-funded research, assisted by land grant universities' Cooperative Extension Systems. Findings and lessons of relevance to each of the challenges are summarized. In this context, we outline how practitioner-scientist partnerships can serve to transform EBP delivery systems, particularly in conjunction with supportive federal policy. PMID:21222151

Impact challenges in community science-with-practice: lessons from PROSPER on transformative practitioner-scientist partnerships and prevention infrastructure development.

PubMed

Spoth, Richard; Greenberg, Mark

2011-09-01

At present, evidence-based programs (EBPs) to reduce youth violence are failing to translate into widespread community practice, despite their potential for impact on this pervasive public health problem. In this paper we address two types of challenges in the achievement of such impact, drawing upon lessons from the implementation of a partnership model called PROSPER. First, we address five key challenges in the achievement of community-level impact through effective community planning and action: readiness and mobilization of community teams; maintaining EBP implementation quality; sustaining community teams and EBPs; demonstrating community-level impact; and continuous, proactive technical assistance. Second, we consider grand challenges in the large-scale translation of EBPs: (1) building, linking and expanding existing infrastructures to support effective EBP delivery systems, and (2) organizing networks of practitioner-scientist partnerships-networks designed to integrate diffusion of EBPs with research that examines effective strategies to do so. The PROSPER partnership model is an evidence-based delivery system for community-based prevention and has evolved through two decades of NIH-funded research, assisted by land grant universities' Cooperative Extension Systems. Findings and lessons of relevance to each of the challenges are summarized. In this context, we outline how practitioner-scientist partnerships can serve to transform EBP delivery systems, particularly in conjunction with supportive federal policy.

Data Science Challenges at the Nexus of Food, Energy, and Water

NASA Astrophysics Data System (ADS)

Eftelioglu, E.; Shekhar, S.

2016-12-01

Food, energy and water (FEW) systems were traditionally analyzed and planned independently to address the challenges of population growth, climate change and urbanization. However, such piece-meal approaches (e.g., bio-fuel subsidy, fertilizers in agriculture) to solving problems in one system (e.g., energy, food) led to unanticipated harms to other systems (e.g., food price increase, water resource depletion and degradation). Thus, understanding the interdependent and interconnected nature of food, energy, and water systems (FEW nexus) is a societal priority. Data Science is crucial for understanding the problem, the interconnections, and the impacts withing FEW nexus. It is also needed for monitoring a variety of Earth resources (e.g., agriculture fields, fresh water lakes, energy needs for cooling or heating, etc.), and trends (e.g., deforestation, pollution, etc.) for timely detection and management of risks, such as impending crop failures and crop-stress anywhere in the world. It is also needed to reduce waste and to improve efficiency, e.g., amount of water and energy needed to produce food. Data Science success stories go beyond the cyber-infrastructure for simulations (e.g., GCMs, AgMIP ) to include precision agriculture and GEOGLAM. Precision agriculture uses cyber-physical systems and data science to increase yield, and reduce fertilizer and pesticide runoffs. The Global Agricultural Monitoring (GEOGLAM) , an international system, uses remotely sensed satellite imagery to monitor major crops for yield forecasts to enable timely interventions to reduce disruptions in global food supply. However, the FEW nexus presents new challenges and opportunities. For example, data science methods need to not only re-examine assumptions such as non-stationarity (e.g., climate change) but also address nexus challenges such as high cost of false positives, (social) feedback loops, and multiple spatio-temporal scale. Acknowledgements: This work was supported in part by the National Science Foundation, and the University of Minnesota. The talk presents outcomes of a recent NSF workshop to explore a research agenda for next generation data science to address the challenges of FEW nexus.

Turbofan Engine Core Compartment Vent Aerodynamic Configuration Development Methodology

NASA Technical Reports Server (NTRS)

Hebert, Leonard J.

2006-01-01

This paper presents an overview of the design methodology used in the development of the aerodynamic configuration of the nacelle core compartment vent for a typical Boeing commercial airplane together with design challenges for future design efforts. Core compartment vents exhaust engine subsystem flows from the space contained between the engine case and the nacelle of an airplane propulsion system. These subsystem flows typically consist of precooler, oil cooler, turbine case cooling, compartment cooling and nacelle leakage air. The design of core compartment vents is challenging due to stringent design requirements, mass flow sensitivity of the system to small changes in vent exit pressure ratio, and the need to maximize overall exhaust system performance at cruise conditions.

A Brief Review on Multivalent Intercalation Batteries with Aqueous Electrolytes.

PubMed

Guduru, Ramesh K; Icaza, Juan C

2016-02-26

Rapidly growing global demand for high energy density rechargeable batteries has driven the research toward developing new chemistries and battery systems beyond Li-ion batteries. Due to the advantages of delivering more than one electron and giving more charge capacity, the multivalent systems have gained considerable attention. At the same time, affordability, ease of fabrication and safety aspects have also directed researchers to focus on aqueous electrolyte based multivalent intercalation batteries. There have been a decent number of publications disclosing capabilities and challenges of several multivalent battery systems in aqueous electrolytes, and while considering an increasing interest in this area, here, we present a brief overview of their recent progress, including electrode chemistries, functionalities and challenges.

Operational Challenges In TDRS Post-Maneuver Orbit Determination

NASA Technical Reports Server (NTRS)

Laing, Jason; Myers, Jessica; Ward, Douglas; Lamb, Rivers

2015-01-01

The GSFC Flight Dynamics Facility (FDF) is responsible for daily and post maneuver orbit determination for the Tracking and Data Relay Satellite System (TDRSS). The most stringent requirement for this orbit determination is 75 meters total position accuracy (3-sigma) predicted over one day for Terra's onboard navigation system. To maintain an accurate solution onboard Terra, a solution is generated and provided by the FDF Four hours after a TDRS maneuver. A number of factors present challenges to this support, such as maneuver prediction uncertainty and potentially unreliable tracking from User satellities. Reliable support is provided by comparing an extended Kalman Filter (estimated using ODTK) against a Batch Least Squares system (estimated using GTDS).

NASA Fixed Wing Project: Green Technologies for Future Aircraft Generation

NASA Technical Reports Server (NTRS)

DelRosario, Ruben

2014-01-01

The NASA Fundamental Aeronautics Fixed Wing (FW) Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advances in multidisciplinary technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. The presentation will highlight the FW Project vision of revolutionary systems and technologies needed to achieve the challenging goals of aviation. Specifically, the primary focus of the FW Project is on the N+3 generation that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe.

Proceedings from the conference on high speed computing: High speed computing and national security

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hirons, K.P.; Vigil, M.; Carlson, R.

1997-07-01

This meeting covered the following topics: technologies/national needs/policies: past, present and future; information warfare; crisis management/massive data systems; risk assessment/vulnerabilities; Internet law/privacy and rights of society; challenges to effective ASCI programmatic use of 100 TFLOPs systems; and new computing technologies.

Educating a New Majority: Transforming America's Educational System for Diversity.

ERIC Educational Resources Information Center

Rendon, Laura I., Ed.; Hope, Richard O., Ed.

This book presents 20 papers on the current status and future needs of disadvantaged minority students in the elementary, secondary, and higher education systems. Papers are grouped into four sections: current challenges to minority education; restructuring schools to foster minority student success; reforming higher education; and leadership…

The Feminist Critique in Epistemological Perspective: Questions of Context in Family Therapy.

ERIC Educational Resources Information Center

Taggart, Morris

1985-01-01

Presents the feminist critique of systems-based family therapy. Discusses the functions of "punctuation,""boundary," and "closure" in systemic epistemology. Explores implications of a new context for family therapy with respect to women's issues, clinical epistemology, and the challenge to raise novel questions in family therapy. (BH)

A systems approach for management of pests and pathogens of nursery crops

Treesearch

Jennifer L. Parke; Niklaus J. Grünwald

2012-01-01

Horticultural nurseries are heterogeneous and spatially complex agricultural systems, which present formidable challenges to management of diseases and pests. Moreover, nursery plants shipped interstate and internationally can serve as important vectors for pathogens and pests that threaten both agriculture and forestry. Current regulatory strategies to prevent this...

Financial management in leading health care systems.

PubMed

Smith, D G; Wheeler, J R; Rivenson, H L; Reiter, K L

2000-01-01

To understand better the financial management practices and strategies of modern health care organizations, we conducted interviews with chief financial officers (CFOs) of several leading health care systems. In this introduction, we present an overview of the project and summary responses on corporate financial structures and strategic challenges facing CFOs.

Representing Historical Knowledge in Geographic Information Systems

ERIC Educational Resources Information Center

Grossner, Karl Eric

2010-01-01

A growing number of historical scholars in social science and humanities fields are using geographic information systems (GIS) to help investigate spatial questions and map their findings. The nature of historical data and historiographic practices present several challenges in using GIS that have been addressed only partially to date. For…

State Board for Community Colleges Strategic Plan, 2000-2002 and Beyond.

ERIC Educational Resources Information Center

Virginia State Dept. of Community Colleges, Richmond.

This report presents the major accomplishments, opportunities, and challenges identified in Virginia Community College System's (VCCS) strategic assessment, as well as goals that address critical issues for the college system. The mission of the VCCS is to provide comprehensive higher education and workforce training programs and services of…

Are nutrient databases and nutrient analysis systems ready for the International implications of nutrigenomics?

USDA-ARS?s Scientific Manuscript database

Our objective is to discuss the implications internationally of the increased focus on nutrigenomics as the underlying basis for individualized health promotion and chronic disease prevention and the challenges presented to existing nutrient database and nutrient analysis systems by these trends. De...

A Chinese Teacher's Perspective on Professional Development in Literacy Education

ERIC Educational Resources Information Center

Syed, Khalida Tanvir

2008-01-01

This paper presents the teaching and learning experiences of a Chinese literacy teacher in narrative form. The participant's story is presented in his own voice, as constructed from interview transcripts. Challenges and struggles faced by the participant include limited professional autonomy in a hierarchal school system, awareness of conflict…

Sustainability Reporting at Schools: Challenges and Benefits

ERIC Educational Resources Information Center

Carbach, Eva; Fischer, Daniel

2017-01-01

Despite advances made there is still an implementation gap with regard to Education for Sustainable Development (ESD) in formal educational systems at the school level. The present paper focuses on sustainability reporting as a recently emerging practice in the school sector. It presents the approach and findings of an exploratory interview study…

Radiation Testing, Characterization and Qualification Challenges for Modern Microelectronics and Photonics Devices and Technologies

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.; Cohn, Lewis M.

2008-01-01

At GOMAC 2007, we discussed a selection of the challenges for radiation testing of modern semiconductor devices focusing on state-of-the-art memory technologies. This included FLASH non-volatile memories (NVMs) and synchronous dynamic random access memories (SDRAMs). In this presentation, we extend this discussion in device packaging and complexity as well as single event upset (SEU) mechanisms using several technology areas as examples including: system-on-a-chip (SOC) devices and photonic or fiber optic systems. The underlying goal is intended to provoke thought for understanding the limitations and interpretation of radiation testing results.

Multilayered Functional Insulation System (MFIS) for AC Power Transmission in High Voltage Hybrid Electrical Propulsion

NASA Technical Reports Server (NTRS)

Lizcano, Maricela

2017-01-01

High voltage hybrid electric propulsion systems are now pushing new technology development efforts for air transportation. A key challenge in hybrid electric aircraft is safe high voltage distribution and transmission of megawatts of power (>20 MW). For the past two years, a multidisciplinary materials research team at NASA Glenn Research Center has investigated the feasibility of distributing high voltage power on future hybrid electric aircraft. This presentation describes the team's approach to addressing this challenge, significant technical findings, and next steps in GRC's materials research effort for MW power distribution on aircraft.

Methodologies for Verification and Validation of Space Launch System (SLS) Structural Dynamic Models: Appendices

NASA Technical Reports Server (NTRS)

Coppolino, Robert N.

2018-01-01

Verification and validation (V&V) is a highly challenging undertaking for SLS structural dynamics models due to the magnitude and complexity of SLS subassemblies and subassemblies. Responses to challenges associated with V&V of Space Launch System (SLS) structural dynamics models are presented in Volume I of this paper. Four methodologies addressing specific requirements for V&V are discussed. (1) Residual Mode Augmentation (RMA). (2) Modified Guyan Reduction (MGR) and Harmonic Reduction (HR, introduced in 1976). (3) Mode Consolidation (MC). Finally, (4) Experimental Mode Verification (EMV). This document contains the appendices to Volume I.

[Quality in the healthcare sector: new strategic measures for new challenges].

PubMed

Larroca, Norberto

2002-01-01

This article reviews the experience of the organizations representing the private healthcare industry in Argentina in their request to improve the quality of care. In it, the author highlights how their collaboration with the PAHO/WHO in the nineties led to the drafting of a Quality Accreditation Handbook, as well as its circulation in most of the countries in the area. Ten years on, the new challenges are analyzed in order to achieve better quality fro all, without limits. With these challenges in mind, the study presents the five programmes being developed at present, by the private health sector as a way of collaborating with society and the government in its progress towards the nationalization of resources and achieving a fairer system and better quality in healthcare.

Methods and metrics challenges of delivery-system research

PubMed Central

2012-01-01

Background Many delivery-system interventions are fundamentally about change in social systems (both planned and unplanned). This systems perspective raises a number of methodological challenges for studying the effects of delivery-system change--particularly for answering questions related to whether the change will work under different conditions and how the change is integrated (or not) into the operating context of the delivery system. Methods The purpose of this paper is to describe the methodological and measurement challenges posed by five key issues in delivery-system research: (1) modeling intervention context; (2) measuring readiness for change; (3) assessing intervention fidelity and sustainability; (4) assessing complex, multicomponent interventions; and (5) incorporating time in delivery-system models to discuss recommendations for addressing these issues. For each issue, we provide recommendations for how research may be designed and implemented to overcome these challenges. Results and conclusions We suggest that a more refined understanding of the mechanisms underlying delivery-system interventions (treatment theory) and the ways in which outcomes for different classes of individuals change over time are fundamental starting points for capturing the heterogeneity in samples of individuals exposed to delivery-system interventions. To support the research recommendations outlined in this paper and to advance understanding of the "why" and "how" questions of delivery-system change and their effects, funding agencies should consider supporting studies with larger organizational sample sizes; longer duration; and nontraditional, mixed-methods designs. A version of this paper was prepared under contract with the Agency for Healthcare Research and Quality (AHRQ), US Department of Health and Human Services for presentation and discussion at a meeting on "The Challenge and Promise of Delivery System Research," held in Sterling, VA, on February 16-17, 2011. The opinions in the paper are those of the author and do not represent the views or recommendations of AHRQ or the US Department of Health and Human Services.1 PMID:22409885

Outside The Box: What Would a Scientist Do with a Dashboard?

NASA Technical Reports Server (NTRS)

Blakeley, Christopher M.

2013-01-01

Growing plants on the International Space Station has always been a challenge, but it is research that must continue in order to support long duration missions. A rotating plant system is now undergoing tests at Kennedy Space Center to help mitigate the challenges of getting water and nutrients effectively to plant roots. Traditionally, lab test data is gathered and presented via spreadsheets which can be confusing and cumbersome to deal with. Using SAP BusinessObjects Dashboards (formerly Xcelsius), see how NASA utilizes this visualization software to help monitor and present a clear picture of the research results.

Accounting for the move to ambulatory patient groups.

PubMed

Boyagian, H R; Dessingue, R F

1998-07-01

This article focuses on the cost accounting challenge an ambulatory patient group (APG)-like-based prospective payment system presents to providers and the issues associated with that challenge. In particular, how can costs be identified, how can the differences in costs be associated with alternative settings, and how do costs identified through a detailed resource costing methodology compare to estimates using alternative measures? The results presented suggest that decisions made based on current measures of ambulatory cost (i.e., charge-based measures) need to be reexamined. These decisions could include which services to provide, what setting is appropriate, and where marketshare opportunities exist.

Dental care in children with developmental disabilities: attention deficit disorder, intellectual disabilities, and autism.

PubMed

Charles, Jane M

2010-01-01

The Federal government reports that 13% of Americans between birth and 18 years of old meet the definition of a child with special health care needs. These children and young adults present unique challenges for both pediatric and general dentists to provide access to the oral health care system--establishing a treatment plan for those with unique medical, behavioral and dental needs and maintaining oral health over the lifetime. The purpose of this article was to describe the characteristics of 3 common developmental disabilities and the challenges these issues present to the oral health care practitioner.

The biological sciences in India

PubMed Central

Dell, Karen

2009-01-01

India is gearing up to become an international player in the life sciences, powered by its recent economic growth and a desire to add biotechnology to its portfolio. In this article, we present the history, current state, and projected future growth of biological research in India. To fulfill its aspirations, India's greatest challenge will be in educating, recruiting, and supporting its next generation of scientists. Such challenges are faced by the US/Europe, but are particularly acute in developing countries that are racing to achieve scientific excellence, perhaps faster than their present educational and faculty support systems will allow. PMID:19204144

A review on technologies and their usage in solid waste monitoring and management systems: Issues and challenges.

PubMed

Hannan, M A; Abdulla Al Mamun, Md; Hussain, Aini; Basri, Hassan; Begum, R A

2015-09-01

In the backdrop of prompt advancement, information and communication technology (ICT) has become an inevitable part to plan and design of modern solid waste management (SWM) systems. This study presents a critical review of the existing ICTs and their usage in SWM systems to unfold the issues and challenges towards using integrated technologies based system. To plan, monitor, collect and manage solid waste, the ICTs are divided into four categories such as spatial technologies, identification technologies, data acquisition technologies and data communication technologies. The ICT based SWM systems classified in this paper are based on the first three technologies while the forth one is employed by almost every systems. This review may guide the reader about the basics of available ICTs and their application in SWM to facilitate the search for planning and design of a sustainable new system. Copyright © 2015 Elsevier Ltd. All rights reserved.

Systems engineering at the nanoscale

NASA Astrophysics Data System (ADS)

Benkoski, Jason J.; Breidenich, Jennifer L.; Wei, Michael C.; Clatterbaughi, Guy V.; Keng, Pei Yuin; Pyun, Jeffrey

2012-06-01

Nanomaterials have provided some of the greatest leaps in technology over the past twenty years, but their relatively early stage of maturity presents challenges for their incorporation into engineered systems. Perhaps even more challenging is the fact that the underlying physics at the nanoscale often run counter to our physical intuition. The current state of nanotechnology today includes nanoscale materials and devices developed to function as components of systems, as well as theoretical visions for "nanosystems," which are systems in which all components are based on nanotechnology. Although examples will be given to show that nanomaterials have indeed matured into applications in medical, space, and military systems, no complete nanosystem has yet been realized. This discussion will therefore focus on systems in which nanotechnology plays a central role. Using self-assembled magnetic artificial cilia as an example, we will discuss how systems engineering concepts apply to nanotechnology.

Wind Turbine Gearbox Oil Filtration and Condition Monitoring

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheng, Shuangwen

This is an invited presentation for a pre-conference workshop, titled advances and opportunities in lubrication: wind turbine, at the 2015 Society of Tribologists and Lubrication Engineers (STLE) Tribology Frontiers Conference held in Denver, CO. It gives a brief overview of wind turbine gearbox oil filtration and condition monitoring by highlighting typical industry practices and challenges. The presentation starts with an introduction by covering recent growth of global wind industry, reliability challenges, benefits of oil filtration and condition monitoring, and financial incentives to conduct wind operation and maintenance research, which includes gearbox oil filtration and condition monitoring work presented herein. Then,more » the presentation moves on to oil filtration by stressing the benefits of filtration, discussing typical main- and offline-loop practices, highlighting important factors considered when specifying a filtration system, and illustrating real-world application challenges through a cold-start example. In the next section on oil condition monitoring, a discussion on oil sample analysis, oil debris monitoring, oil cleanliness measurements and filter analysis is given based on testing results mostly obtained by and at NREL, and by pointing out a few challenges with oil sample analysis. The presentation concludes with a brief touch on future research and development (R and D) opportunities. It is hoping that the information presented can inform the STLE community to start or redirect their R and D work to help the wind industry advance.« less

No Mickey Mouse Operation: Despite Cutting-Edge Technology, Free Book Delivery, and Bilingual Programming, Luring Users Is the Orange County Library's Greatest Challenge

ERIC Educational Resources Information Center

Rogers, Michael

2004-01-01

Living in the vast shadow cast by the spires of the Magic Kingdom presents special challenges for Orlando's Orange County Library System (OCLS), the most formidable of which is increasing its relatively small user base. The library additionally faces tension between the administration and staff, political strife on the board, and looming contract…

WikiSensing: An Online Collaborative Approach for Sensor Data Management

PubMed Central

Silva, Dilshan; Ghanem, Moustafa; Guo, Yike

2012-01-01

This paper presents a new methodology for collaborative sensor data management known as WikiSensing. It is a novel approach that incorporates online collaboration with sensor data management. We introduce the work on this research by describing the motivation and challenges of designing and developing an online collaborative sensor data management system. This is followed by a brief survey on popular sensor data management and online collaborative systems. We then present the architecture for WikiSensing highlighting its main components and features. Several example scenarios are described to present the functionality of the system. We evaluate the approach by investigating the performance of aggregate queries and the scalability of the system. PMID:23201997

Digital Video Over Space Systems and Networks

NASA Technical Reports Server (NTRS)

Grubbs, Rodney

2010-01-01

This slide presentation reviews the improvements and challenges that digital video provides over analog video. The use of digital video over IP options and trade offs, link integrity and latency are reviewed.

Integrated river basin management, ICT and DSS: Challenges and needs

NASA Astrophysics Data System (ADS)

Gourbesville, Philippe

River basin management is a complex task. Therefore, instruments that help to assess the present situation and assist in the development and evaluation of solutions may be important. Since several decades and after the implementation of the first compulsory legal environments and institutional organizations for IWRM and IRBM, the need for an efficient support in the different decision-making processes has emerged. After several experiences, the demonstration of the interest of ICT and DSS systems is obvious in the water resources management domain. However and until now, most of the efforts have been focused on the theoretical aspects with very few integrations into operational approaches. The implementation of the new European water framework directive (2000) represents today one key example from which some lessons can be learned in the way of definition and use of ICT and DSS systems for IWRM and IRBM. The paper presents the concepts available through ICT and DSS. The example of the WFD is used to underline the challenges and the difficulties for the elaboration of new tools - DSSs - which could be able to answer of the challenges of IWRM and IRBM.

Implementation of workflow engine technology to deliver basic clinical decision support functionality

PubMed Central

2011-01-01

Background Workflow engine technology represents a new class of software with the ability to graphically model step-based knowledge. We present application of this novel technology to the domain of clinical decision support. Successful implementation of decision support within an electronic health record (EHR) remains an unsolved research challenge. Previous research efforts were mostly based on healthcare-specific representation standards and execution engines and did not reach wide adoption. We focus on two challenges in decision support systems: the ability to test decision logic on retrospective data prior prospective deployment and the challenge of user-friendly representation of clinical logic. Results We present our implementation of a workflow engine technology that addresses the two above-described challenges in delivering clinical decision support. Our system is based on a cross-industry standard of XML (extensible markup language) process definition language (XPDL). The core components of the system are a workflow editor for modeling clinical scenarios and a workflow engine for execution of those scenarios. We demonstrate, with an open-source and publicly available workflow suite, that clinical decision support logic can be executed on retrospective data. The same flowchart-based representation can also function in a prospective mode where the system can be integrated with an EHR system and respond to real-time clinical events. We limit the scope of our implementation to decision support content generation (which can be EHR system vendor independent). We do not focus on supporting complex decision support content delivery mechanisms due to lack of standardization of EHR systems in this area. We present results of our evaluation of the flowchart-based graphical notation as well as architectural evaluation of our implementation using an established evaluation framework for clinical decision support architecture. Conclusions We describe an implementation of a free workflow technology software suite (available at http://code.google.com/p/healthflow) and its application in the domain of clinical decision support. Our implementation seamlessly supports clinical logic testing on retrospective data and offers a user-friendly knowledge representation paradigm. With the presented software implementation, we demonstrate that workflow engine technology can provide a decision support platform which evaluates well against an established clinical decision support architecture evaluation framework. Due to cross-industry usage of workflow engine technology, we can expect significant future functionality enhancements that will further improve the technology's capacity to serve as a clinical decision support platform. PMID:21477364

Measuring Cardiac Autonomic Nervous System (ANS) Activity in Toddlers - Resting and Developmental Challenges.

PubMed

Bush, Nicole R; Caron, Zoe K; Blackburn, Katherine S; Alkon, Abbey

2016-02-25

The autonomic nervous system (ANS) consists of two branches, the parasympathetic and sympathetic nervous systems, and controls the function of internal organs (e.g., heart rate, respiration, digestion) and responds to everyday and adverse experiences (1). ANS measures in children have been found to be related to behavior problems, emotion regulation, and health (2-7). Therefore, understanding the factors that affect ANS development during early childhood is important. Both branches of the ANS affect young children's cardiovascular responses to stimuli and have been measured noninvasively, via external monitoring equipment, using valid and reliable measures of physiological change (8-11). However, there are few studies of very young children with simultaneous measures of the parasympathetic and sympathetic nervous systems, which limits understanding of the integrated functioning of the two systems. In addition, the majority of existing studies of young children report on infants' resting ANS measures or their reactivity to commonly used mother-child interaction paradigms, and less is known about ANS reactivity to other challenging conditions. We present a study design and standardized protocol for a non-invasive and rapid assessment of cardiac autonomic control in 18 month old children. We describe methods for continuous monitoring of the parasympathetic and sympathetic branches of the ANS under resting and challenge conditions during a home or laboratory visit and provide descriptive findings from our sample of 140 ethnically diverse toddlers using validated equipment and scoring software. Results revealed that this protocol can produce a range of physiological responses to both resting and developmentally challenging conditions, as indicated by changes in heart rate and indices of parasympathetic and sympathetic activity. Individuals demonstrated variability in resting levels, responses to challenges, and challenge reactivity, which provides additional evidence that this protocol is useful for the examination of ANS individual differences for toddlers.

Industrial Adoption of Model-Based Systems Engineering: Challenges and Strategies

NASA Astrophysics Data System (ADS)

Maheshwari, Apoorv

As design teams are becoming more globally integrated, one of the biggest challenges is to efficiently communicate across the team. The increasing complexity and multi-disciplinary nature of the products are also making it difficult to keep track of all the information generated during the design process by these global team members. System engineers have identified Model-based Systems Engineering (MBSE) as a possible solution where the emphasis is placed on the application of visual modeling methods and best practices to systems engineering (SE) activities right from the beginning of the conceptual design phases through to the end of the product lifecycle. Despite several advantages, there are multiple challenges restricting the adoption of MBSE by industry. We mainly consider the following two challenges: a) Industry perceives MBSE just as a diagramming tool and does not see too much value in MBSE; b) Industrial adopters are skeptical if the products developed using MBSE approach will be accepted by the regulatory bodies. To provide counter evidence to the former challenge, we developed a generic framework for translation from an MBSE tool (Systems Modeling Language, SysML) to an analysis tool (Agent-Based Modeling, ABM). The translation is demonstrated using a simplified air traffic management problem and provides an example of a potential quite significant value: the ability to use MBSE representations directly in an analysis setting. For the latter challenge, we are developing a reference model that uses SysML to represent a generic infusion pump and SE process for planning, developing, and obtaining regulatory approval of a medical device. This reference model demonstrates how regulatory requirements can be captured effectively through model-based representations. We will present another case study at the end where we will apply the knowledge gained from both case studies to a UAV design problem.

Enhancing astronaut performance using sensorimotor adaptability training

PubMed Central

Bloomberg, Jacob J.; Peters, Brian T.; Cohen, Helen S.; Mulavara, Ajitkumar P.

2015-01-01

Astronauts experience disturbances in balance and gait function when they return to Earth. The highly plastic human brain enables individuals to modify their behavior to match the prevailing environment. Subjects participating in specially designed variable sensory challenge training programs can enhance their ability to rapidly adapt to novel sensory situations. This is useful in our application because we aim to train astronauts to rapidly formulate effective strategies to cope with the balance and locomotor challenges associated with new gravitational environments—enhancing their ability to “learn to learn.” We do this by coupling various combinations of sensorimotor challenges with treadmill walking. A unique training system has been developed that is comprised of a treadmill mounted on a motion base to produce movement of the support surface during walking. This system provides challenges to gait stability. Additional sensory variation and challenge are imposed with a virtual visual scene that presents subjects with various combinations of discordant visual information during treadmill walking. This experience allows them to practice resolving challenging and conflicting novel sensory information to improve their ability to adapt rapidly. Information obtained from this work will inform the design of the next generation of sensorimotor countermeasures for astronauts. PMID:26441561

Enhancing astronaut performance using sensorimotor adaptability training.

PubMed

Bloomberg, Jacob J; Peters, Brian T; Cohen, Helen S; Mulavara, Ajitkumar P

2015-01-01

Astronauts experience disturbances in balance and gait function when they return to Earth. The highly plastic human brain enables individuals to modify their behavior to match the prevailing environment. Subjects participating in specially designed variable sensory challenge training programs can enhance their ability to rapidly adapt to novel sensory situations. This is useful in our application because we aim to train astronauts to rapidly formulate effective strategies to cope with the balance and locomotor challenges associated with new gravitational environments-enhancing their ability to "learn to learn." We do this by coupling various combinations of sensorimotor challenges with treadmill walking. A unique training system has been developed that is comprised of a treadmill mounted on a motion base to produce movement of the support surface during walking. This system provides challenges to gait stability. Additional sensory variation and challenge are imposed with a virtual visual scene that presents subjects with various combinations of discordant visual information during treadmill walking. This experience allows them to practice resolving challenging and conflicting novel sensory information to improve their ability to adapt rapidly. Information obtained from this work will inform the design of the next generation of sensorimotor countermeasures for astronauts.

Using a participatory evaluation design to create an online data collection and monitoring system for New Mexico's Community Health Councils.

PubMed

Andrews, M L; Sánchez, V; Carrillo, C; Allen-Ananins, B; Cruz, Y B

2014-02-01

We present the collaborative development of a web-based data collection and monitoring plan for thirty-two county councils within New Mexico's health council system. The monitoring plan, a key component in our multiyear participatory statewide evaluation process, was co-developed with the end users: representatives of the health councils. Guided by the Institute of Medicine's Community, Health Improvement Process framework, we first developed a logic model that delineated processes and intermediate systems-level outcomes in council development, planning, and community action. Through the online system, health councils reported data on intermediate outcomes, including policy changes and funds leveraged. The system captured data that were common across the health council system, yet was also flexible so that councils could report their unique accomplishments at the county level. A main benefit of the online system was that it provided the ability to assess intermediate, outcomes across the health council system. Developing the system was not without challenges, including creating processes to ensure participation across a large rural state; creating shared understanding of intermediate outcomes and indicators; and overcoming technological issues. Even through the challenges, however, the benefits of committing to using participatory processes far outweighed the challenges. Copyright © 2013 Elsevier Ltd. All rights reserved.

Critical Success Factors (CSFs) for Implementation of Enterprise Resource Planning (ERP) Systems in Various Industries, Including Institutions of Higher Education (IHEs)

ERIC Educational Resources Information Center

Debrosse-Bruno, Marie Michael

2017-01-01

Enterprise Resource Planning (ERP) systems present a management problem for various industries including institutions of higher education (IHEs) because they are costly to acquire, challenging to implement, and often fail to meet anticipated expectations. ERP systems are highly complex due to the nature of the operations they support. This…

Design and Evaluation of a DIY Construction System for Educational Robot Kits

ERIC Educational Resources Information Center

Vandevelde, Cesar; Wyffels, Francis; Ciocci, Maria-Cristina; Vanderborght, Bram; Saldien, Jelle

2016-01-01

Building a robot from scratch in an educational context can be a challenging prospect. While a multitude of projects exist that simplify the electronics and software aspects of a robot, the same cannot be said for construction systems for robotics. In this paper, we present our efforts to create a low-cost do-it-yourself construction system for…

Advances in Orion's On-Orbit Guidance and Targeting System Architecture

NASA Technical Reports Server (NTRS)

Scarritt, Sara K.; Fill, Thomas; Robinson, Shane

2015-01-01

NASA's manned spaceflight programs have a rich history of advancing onboard guidance and targeting technology. In order to support future missions, the guidance and targeting architecture for the Orion Multi-Purpose Crew Vehicle must be able to operate in complete autonomy, without any support from the ground. Orion's guidance and targeting system must be sufficiently flexible to easily adapt to a wide array of undecided future missions, yet also not cause an undue computational burden on the flight computer. This presents a unique design challenge from the perspective of both algorithm development and system architecture construction. The present work shows how Orion's guidance and targeting system addresses these challenges. On the algorithm side, the system advances the state-of-the-art by: (1) steering burns with a simple closed-loop guidance strategy based on Shuttle heritage, and (2) planning maneuvers with a cutting-edge two-level targeting routine. These algorithms are then placed into an architecture designed to leverage the advantages of each and ensure that they function in concert with one another. The resulting system is characterized by modularity and simplicity. As such, it is adaptable to the on-orbit phases of any future mission that Orion may attempt.

Anatomy and Physiology of Multiscale Modeling and Simulation in Systems Medicine.

PubMed

Mizeranschi, Alexandru; Groen, Derek; Borgdorff, Joris; Hoekstra, Alfons G; Chopard, Bastien; Dubitzky, Werner

2016-01-01

Systems medicine is the application of systems biology concepts, methods, and tools to medical research and practice. It aims to integrate data and knowledge from different disciplines into biomedical models and simulations for the understanding, prevention, cure, and management of complex diseases. Complex diseases arise from the interactions among disease-influencing factors across multiple levels of biological organization from the environment to molecules. To tackle the enormous challenges posed by complex diseases, we need a modeling and simulation framework capable of capturing and integrating information originating from multiple spatiotemporal and organizational scales. Multiscale modeling and simulation in systems medicine is an emerging methodology and discipline that has already demonstrated its potential in becoming this framework. The aim of this chapter is to present some of the main concepts, requirements, and challenges of multiscale modeling and simulation in systems medicine.

NASA's EOSDIS Cumulus: Ingesting, Archiving, Managing, and Distributing from Commercial Cloud

NASA Astrophysics Data System (ADS)

Baynes, K.; Ramachandran, R.; Pilone, D.; Quinn, P.; Schuler, I.; Gilman, J.; Jazayeri, A.

2017-12-01

NASA's Earth Observing System Data and Information System (EOSDIS) has been working towards a vision of a cloud-based, highly-flexible, ingest, archive, management, and distribution system for its ever-growing and evolving data holdings. This system, Cumulus, is emerging from its prototyping stages and is poised to make a huge impact on how NASA manages and disseminates its Earth science data. This talk will outline the motivation for this work, present the achievements and hurdles of the past 18 months and will chart a course for the future expansion of the Cumulus expansion. We will explore on not just the technical, but also the socio-technical challenges that we face in evolving a system of this magnitude into the cloud and how we are rising to meet those challenges through open collaboration and intentional stakeholder engagement.

EMASS (tm): An expandable solution for NASA space data storage needs

NASA Technical Reports Server (NTRS)

Peterson, Anthony L.; Cardwell, P. Larry

1992-01-01

The data acquisition, distribution, processing, and archiving requirements of NASA and other U.S. Government data centers present significant data management challenges that must be met in the 1990's. The Earth Observing System (EOS) project alone is expected to generate daily data volumes greater than 2 Terabytes (2(10)(exp 12) Bytes). As the scientific community makes use of this data their work product will result in larger, increasingly complex data sets to be further exploited and managed. The challenge for data storage systems is to satisfy the initial data management requirements with cost effective solutions that provide for planned growth. This paper describes the expandable architecture of the E-Systems Modular Automated Storage System (EMASS (TM)), a mass storage system which is designed to support NASA's data capture, storage, distribution, and management requirements into the 21st century.

EMASS (trademark): An expandable solution for NASA space data storage needs

NASA Technical Reports Server (NTRS)

Peterson, Anthony L.; Cardwell, P. Larry

1991-01-01

The data acquisition, distribution, processing, and archiving requirements of NASA and other U.S. Government data centers present significant data management challenges that must be met in the 1990's. The Earth Observing System (EOS) project alone is expected to generate daily data volumes greater than 2 Terabytes (2 x 10(exp 12) Bytes). As the scientific community makes use of this data, their work will result in larger, increasingly complex data sets to be further exploited and managed. The challenge for data storage systems is to satisfy the initial data management requirements with cost effective solutions that provide for planned growth. The expendable architecture of the E-Systems Modular Automated Storage System (EMASS(TM)), a mass storage system which is designed to support NASA's data capture, storage, distribution, and management requirements into the 21st century is described.

Riparian Wetlands: Mapping

EPA Science Inventory

Riparian wetlands are critical systems that perform functions and provide services disproportionate to their extent in the landscape. Mapping wetlands allows for better planning, management, and modeling, but riparian wetlands present several challenges to effective mapping due t...

Field Evaluation of Detection-Control System

DOT National Transportation Integrated Search

2014-10-01

High-speed signalized intersections present unique challenges to improving highway safety. Techniques for achieving safety often have an adverse effect on efficiency, and techniques for achieving efficiency sometimes have an adverse effect on safety....

Where systems biology meets postharvest

USDA-ARS?s Scientific Manuscript database

Interpreting fruit metabolism, particularly tree fruit metabolism, presents unique challenges. Long periods from tree establishment to fruiting render techniques directed towards reducing the complexity of metabolic mechanisms, such as genomic modification, relatively difficult. Consequently, holi...

Teleglaucoma: improving access and efficiency for glaucoma care.

PubMed

Kassam, Faazil; Yogesan, Kanagasingam; Sogbesan, Enitan; Pasquale, Louis R; Damji, Karim F

2013-01-01

Teleglaucoma is the application of telemedicine for glaucoma. We review and present the current literature on teleglaucoma; present our experience with teleglaucoma programs in Alberta, Canada and Western Australia; and discuss the challenges and opportunities in this emerging field. Teleglaucoma is a novel area that was first explored a little over a decade ago and early studies highlighted the technical challenges of delivering glaucoma care remotely. Advanced technologies have since emerged that show great promise in providing access to underserviced populations. Additionally, these technologies can improve the efficiency of healthcare systems burdened with an increasing number of patients with glaucoma, and a limited supply of ophthalmologists. Additional benefits of teleglaucoma systems include e-learning and e-research. Further work is needed to fully validate and study the cost and comparative effectiveness of this approach relative to traditional models of healthcare.

Teleglaucoma: Improving Access and Efficiency for Glaucoma Care

PubMed Central

Kassam, Faazil; Yogesan, Kanagasingam; Sogbesan, Enitan; Pasquale, Louis R.; Damji, Karim F.

2013-01-01

Teleglaucoma is the application of telemedicine for glaucoma. We review and present the current literature on teleglaucoma; present our experience with teleglaucoma programs in Alberta, Canada and Western Australia; and discuss the challenges and opportunities in this emerging field. Teleglaucoma is a novel area that was first explored a little over a decade ago and early studies highlighted the technical challenges of delivering glaucoma care remotely. Advanced technologies have since emerged that show great promise in providing access to underserviced populations. Additionally, these technologies can improve the efficiency of healthcare systems burdened with an increasing number of patients with glaucoma, and a limited supply of ophthalmologists. Additional benefits of teleglaucoma systems include e-learning and e-research. Further work is needed to fully validate and study the cost and comparative effectiveness of this approach relative to traditional models of healthcare. PMID:23741133

Radio-frequency flexible and stretchable electronics: the need, challenges and opportunities

NASA Astrophysics Data System (ADS)

Jung, Yei Hwan; Seo, Jung-Hun; Zhang, Huilong; Lee, Juhwan; Cho, Sang June; Chang, Tzu-Hsuan; Ma, Zhenqiang

2017-05-01

Successful integration of ultrathin flexible or stretchable systems with new applications, such as medical devices and biodegradable electronics, have intrigued many researchers and industries around the globe to seek materials and processes to create high-performance, non-invasive and cost-effective electronics to match those of state-of-the-art devices. Nevertheless, the crucial concept of transmitting data or power wirelessly for such unconventional devices has been difficult to realize due to limitations of radio-frequency (RF) electronics in individual components that form a wireless circuitry, such as antenna, transmission line, active devices, passive devices etc. To overcome such challenges, these components must be developed in a step-by-step manner, as each component faces a number of different challenges in ultrathin formats. Here, we report on materials and design considerations for fabricating flexible and stretchable electronics systems that operate in the microwave level. High-speed flexible active devices, including cost effective Si-based strained MOSFETs, GaAs-based HBTs and GaN-based HEMTs, performing at multi-gigahertz frequencies are presented. Furthermore, flexible or stretchable passive devices, including capacitors, inductors and transmission lines that are vital parts of a microwave circuitry are also demonstrated. We also present unique applications using the presented flexible or stretchable RF components, including wearable RF electronics and biodegradable RF electronics, which were impossible to achieve using conventional rigid, wafer-based technology. Further opportunities like implantable systems exist utilizing such ultrathin RF components, which are discussed in this report as well.

The role of the Long Duration Exposure Facility in the development of space systems

NASA Technical Reports Server (NTRS)

Little, Sally A.

1992-01-01

The Long Duration Exposure Facility (LDEF) presents the international, aerospace community with an unprecedented opportunity to examine the synergistic, long term, space environmental effects on systems and materials. The analysis of the data within appropriate environmental contexts is essential to the overall process of advancing the understanding of space environmental effects needed for the continuing development of strategies to improve the reliability and durability of space systems and to effectively deal with the future challenges that new space initiatives will likely present.

Aikido: a model for brief strategic therapy.

PubMed

Saposnek, D T

1980-09-01

Building on Watzlawick's observations of certain similarities between judo and brief strategic therapy, this paper develops theoretic and pragmatic parallels between brief strategic therapy and a sophisticated martial art system, Aikido. After presenting the contextual similarities of the two conceptual systems as parallel "challenges" to the therapist and Aikidoist to effect change, the similarities in basic principles of practice are presented. The similarities in the philosophical and attitudinal positions of these conceptual systems are then delineated, followed by a case example that integrates the various concepts in the paper.

Risk Evaluation of Bogie System Based on Extension Theory and Entropy Weight Method

PubMed Central

Du, Yanping; Zhang, Yuan; Zhao, Xiaogang; Wang, Xiaohui

2014-01-01

A bogie system is the key equipment of railway vehicles. Rigorous practical evaluation of bogies is still a challenge. Presently, there is overreliance on part-specific experiments in practice. In the present work, a risk evaluation index system of a bogie system has been established based on the inspection data and experts' evaluation. Then, considering quantitative and qualitative aspects, the risk state of a bogie system has been evaluated using an extension theory and an entropy weight method. Finally, the method has been used to assess the bogie system of four different samples. Results show that this method can assess the risk state of a bogie system exactly. PMID:25574159

Risk evaluation of bogie system based on extension theory and entropy weight method.

PubMed

Du, Yanping; Zhang, Yuan; Zhao, Xiaogang; Wang, Xiaohui

2014-01-01

A bogie system is the key equipment of railway vehicles. Rigorous practical evaluation of bogies is still a challenge. Presently, there is overreliance on part-specific experiments in practice. In the present work, a risk evaluation index system of a bogie system has been established based on the inspection data and experts' evaluation. Then, considering quantitative and qualitative aspects, the risk state of a bogie system has been evaluated using an extension theory and an entropy weight method. Finally, the method has been used to assess the bogie system of four different samples. Results show that this method can assess the risk state of a bogie system exactly.

Information management challenges of the EOS Data and Information System

NASA Technical Reports Server (NTRS)

Mcdonald, Kenneth R.; Blake, Deborah J.

1991-01-01

An overview of the current information management concepts that are embodied in the plans for the Earth Observing System Data and Information System (EOSDIS) is presented, and some of the technology development and application areas that are envisioned to be particularly challenging are introduced. The Information Management System (IMS) is the EOSDIS element that provides the primary interface between the science users and the data products and services of EOSDIS. The goals of IMS are to define a clear and complete set of functional requirements and to apply innovative methods and technologies to satisfy them. The information management functions are described in detail, and some applicable technolgies are discussed. Some of the general issues affecting the successful development and operation of the information management element are addressed.

Laser-based firing systems for prompt initiation of secondary explosives

NASA Technical Reports Server (NTRS)

Meeks, Kent D.; Setchell, Robert E.

1993-01-01

Motivated by issues of weapon safety and security, laser based firing systems for promptly initiating secondary explosives have been under active development at Sandia National Laboratories for more than four years. Such a firing system consists of miniaturized, Q-switched, solid-state laser, optical detonators, optical safety switches, and elements for splitting, coupling, and transmitting the laser output. Potential system applications pose significant challenges in terms of server mechanical and thermal environments and packaging constraints, while requiring clear demonstration of safety enhancements. The Direct Optical Initiation (DOI) Program at Sandia is addressing these challenges through progress development phases during which the design, fabrication, and testing of prototype hardware is aimed at more difficult application requirements. A brief history of the development program, and a summary of current and planned activities, will be presented.

Socio-Hydrology: Conceptual and Methodological Challenges in the Bidirectional Coupling of Human and Water Systems

NASA Astrophysics Data System (ADS)

Scott, C. A.

2014-12-01

This presentation reviews conceptual advances in the emerging field of socio-hydrology that focuses on coupled human and water systems. An important current challenge is how to better couple the bidirectional influences between human and water systems, which lead to emergent dynamics. The interactions among (1) the structure and dynamics of systems with (2) human values and norms lead to (3) outcomes, which in turn influence subsequent interactions. Human influences on hydrological systems are relatively well understood, chiefly resulting from developments in the field of water resources. The ecosystem-service concept of cultural value has expanded understanding of decision-making beyond economic rationality criteria. Hydrological impacts on social processes are less well developed conceptually, but this is changing with growing attention to vulnerability, adaptation, and resilience, particularly in the face of climate change. Methodological limitations, especially in characterizing the range of human responses to hydrological events and drivers, still pose challenges to modeling bidirectional human-water influences. Evidence from multiple case studies, synthesized in more broadly generic syndromes, helps surmount these methodological limitations and offers the potential to improve characterization and quantification of socio-hydrological systems.

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges.

PubMed

Biswaro, Lubhandwa S; da Costa Sousa, Mauricio G; Rezende, Taia M B; Dias, Simoni C; Franco, Octavio L

2018-01-01

Antimicrobial peptides are sequences of amino acids, which present activity against microorganisms. These peptides were discovered over 70 years ago, and are abundant in nature from soil bacteria, insects, amphibians to mammals and plants. They vary in amino acids number, the distance between amino acids within individual peptide structure, net charge, solubility and other physical chemical properties as well as differ in mechanism of action. These peptides may provide an alternative treatment to conventional antibiotics, which encounter resistance such as the peptide nisin applied in treating methicillin resistant Staphylococcus aureus (MRSA) or may behave synergistically with known antibiotics against parasites for instance, nisin Z when used in synergy with ampicillin reported better activity against Pseudomonas fluorescens than when the antibiotic was alone. AMPs are known to be active against viruses, bacteria, fungi and protozoans. Nanotechnology is an arena which explores the synthesis, characterization and application of an array of delivery systems at a one billionth of meter scale. Such systems are implemented to deliver drugs, proteins, vaccines, and peptides. The role of nanotechnology in delivering AMPs is still at its early development stage. There are challenges of incorporating AMPs into drug delivery system. This review intends to explore in depth, the role of nanotechnology in delivering AMPs as well as presenting the current advances and accompanying challenges of the technology.

The Other Inconvenient Truth: Feeding 9 Billion While Sustaining the Earth System

NASA Astrophysics Data System (ADS)

Foley, J. A.

2010-12-01

As the international community focuses on climate change as the great challenge of our era, we have been largely ignoring another looming problem — the global crisis in agriculture, food security and the environment. Our use of land, particularly for agriculture, is absolutely essential to the success of the human race: we depend on agriculture to supply us with food, feed, fiber, and, increasingly, biofuels. Without a highly efficient, productive, and resilient agricultural system, our society would collapse almost overnight. But we are demanding more and more from our global agricultural systems, pushing them to their very limits. Continued population growth (adding more than 70 million people to the world every year), changing dietary preferences (including more meat and dairy consumption), rising energy prices, and increasing needs for bioenergy sources are putting tremendous pressure on the world’s resources. And, if we want any hope of keeping up with these demands, we’ll need to double the agricultural production of the planet in the next 30 to 40 years. Meeting these huge new agricultural demands will be one of the greatest challenges of the 21st century. At present, it is completely unclear how (and if) we can do it. If this wasn’t enough, we must also address the massive environmental impacts of our current agricultural practices, which new evidence indicates rival the impacts of climate change. Simply put, providing for the basic needs of 9 billion-plus people, without ruining the biosphere in the process, will be one of the greatest challenges our species has ever faced. In this presentation, I will present a new framework for evaluating and assessing global patterns of agriculture, food / fiber / fuel production, and their relationship to the earth system, particularly in terms of changing stocks and flows of water, nutrients and carbon in our planetary environment. This framework aims to help us manage the challenges of increasing global food security -- in the fact of dramatically increasing demand -- while greatly reducing the impact of agriculture on the earth system.

Non-invasive systemic drug delivery through mucosal routes.

PubMed

Goyal, Amit K; Singh, Ranjit; Chauhan, Gaurav; Rath, Goutam

2018-04-24

Science of drug delivery has achieved tremendous milestones in the last few decades. Emergence of novel drug delivery techniques and the most popular nanotechnology directed the drug delivery to another level. Without any doubt, present technology holds the proficiency to approach even the intercellular targets. Between all these success auras, there lies wads of giant challenges. One such challenge is delivering the molecule directly to the blood stream. Parenteral route is considered as the most effective route for delivering active pharmaceutical substances, but is associated with major disadvantages of painful drug delivery. Modern drug delivery suggests several approaches to outstrip this painful phenomenon. In the present article, we represent a new systematic vision to understand the ability and desirability of mucosal sites to achieve painless drug delivery. Human mucosa presents supreme proximity to the blood circulation that one can even observe with naked eye. Advances in drug delivery provide numerous approaches to exploit the mucosa for systemic reach. However, the revolutionary success is still unapproachable, with an understandable reason of associated complexities and challenges. This manuscript summarizes the significance of each mucosal site, on the basis of anatomical-physiological grounds. Particular attention is given to rationalize the selection of disease and a suitable drug delivery approach for its treatment.

Atmosphere Revitalization Technology Development for Crewed Space Exploration

NASA Technical Reports Server (NTRS)

Perry, Jay L.; Carrasquillo, Robyn L.; Harris, Danny W.

2006-01-01

As space exploration objectives extend human presence beyond low Earth orbit, the solutions to technological challenges presented by supporting human life in the hostile space environment must build upon experience gained during past and present crewed space exploration programs. These programs and the cabin atmosphere revitalization process technologies and systems developed for them represent the National Aeronautics and Space Administration s (NASA) past and present operational knowledge base for maintaining a safe, comfortable environment for the crew. The contributions of these programs to the NASA s technological and operational working knowledge base as well as key strengths and weaknesses to be overcome are discussed. Areas for technological development to address challenges inherent with the Vision for Space Exploration (VSE) are presented and a plan for their development employing unit operations principles is summarized

An Adaptive Method for Reducing Clock Skew in an Accumulative Z-Axis Interconnect System

NASA Technical Reports Server (NTRS)

Bolotin, Gary; Boyce, Lee

1997-01-01

This paper will present several methods for adjusting clock skew variations that occur in a n accumulative z-axis interconnect system. In such a system, delay between modules in a function of their distance from one another. Clock distribution in a high-speed system, where clock skew must be kept to a minimum, becomes more challenging when module order is variable before design.

Improved obstacle avoidance and navigation for an autonomous ground vehicle

NASA Astrophysics Data System (ADS)

Giri, Binod; Cho, Hyunsu; Williams, Benjamin C.; Tann, Hokchhay; Shakya, Bicky; Bharam, Vishal; Ahlgren, David J.

2015-01-01

This paper presents improvements made to the intelligence algorithms employed on Q, an autonomous ground vehicle, for the 2014 Intelligent Ground Vehicle Competition (IGVC). In 2012, the IGVC committee combined the formerly separate autonomous and navigation challenges into a single AUT-NAV challenge. In this new challenge, the vehicle is required to navigate through a grassy obstacle course and stay within the course boundaries (a lane of two white painted lines) that guide it toward a given GPS waypoint. Once the vehicle reaches this waypoint, it enters an open course where it is required to navigate to another GPS waypoint while avoiding obstacles. After reaching the final waypoint, the vehicle is required to traverse another obstacle course before completing the run. Q uses modular parallel software architecture in which image processing, navigation, and sensor control algorithms run concurrently. A tuned navigation algorithm allows Q to smoothly maneuver through obstacle fields. For the 2014 competition, most revisions occurred in the vision system, which detects white lines and informs the navigation component. Barrel obstacles of various colors presented a new challenge for image processing: the previous color plane extraction algorithm would not suffice. To overcome this difficulty, laser range sensor data were overlaid on visual data. Q also participates in the Joint Architecture for Unmanned Systems (JAUS) challenge at IGVC. For 2014, significant updates were implemented: the JAUS component accepted a greater variety of messages and showed better compliance to the JAUS technical standard. With these improvements, Q secured second place in the JAUS competition.

An Analysis of an Automatic Coolant Bypass in the International Space Station Node 2 Internal Active Thermal Control System

NASA Technical Reports Server (NTRS)

Clanton, Stephen E.; Holt, James M.; Turner, Larry D. (Technical Monitor)

2001-01-01

A challenging part of International Space Station (ISS) thermal control design is the ability to incorporate design changes into an integrated system without negatively impacting performance. The challenge presents itself in that the typical ISS Internal Active Thermal Control System (IATCS) consists of an integrated hardware/software system that provides active coolant resources to a variety of users. Software algorithms control the IATCS to specific temperatures, flow rates, and pressure differentials in order to meet the user-defined requirements. What may seem to be small design changes imposed on the system may in fact result in system instability or the temporary inability to meet user requirements. The purpose of this paper is to provide a brief description of the solution process and analyses used to implement one such design change that required the incorporation of an automatic coolant bypass in the ISS Node 2 element.

Sensium: an ultra-low-power wireless body sensor network platform: design & application challenges.

PubMed

Wong, A W; McDonagh, D; Omeni, O; Nunn, C; Hernandez-Silveira, M; Burdett, A J

2009-01-01

In this paper we present a system-on-chip for wireless body sensor networks, which integrates a transceiver, hardware MAC protocol, microprocessor, IO peripherals, memories, ADC and custom sensor interfaces. Addressing the challenges in the design, this paper will continue to discuss the issues in the applications of this technology to body worn monitoring for real-time measurement of ECG, heart rate, physical activity, respiration and/or skin temperature. Two application challenges are described; the real-time measurement of energy expenditure using the LifePebble, and; the development issues surrounding the 'Digital Patch'.

Transboundary fisheries science: Meeting the challenges of inland fisheries management in the 21st century

USGS Publications Warehouse

Midway, Stephen R.; Wagner, Tyler; Zydlewski, Joseph D.; Irwin, Brian J.; Paukert, Craig P.

2016-01-01

Managing inland fisheries in the 21st century presents several obstacles, including the need to view fisheries from multiple spatial and temporal scales, which usually involves populations and resources spanning sociopolitical boundaries. Though collaboration is not new to fisheries science, inland aquatic systems have historically been managed at local scales and present different challenges than in marine or large freshwater systems like the Laurentian Great Lakes. Therefore, we outline a flexible strategy that highlights organization, cooperation, analytics, and implementation as building blocks toward effectively addressing transboundary fisheries issues. Additionally, we discuss the use of Bayesian hierarchical models (within the analytical stage), due to their flexibility in dealing with the variability present in data from multiple scales. With growing recognition of both ecological drivers that span spatial and temporal scales and the subsequent need for collaboration to effectively manage heterogeneous resources, we expect implementation of transboundary approaches to become increasingly critical for effective inland fisheries management.

The Phases Differential Astrometry Data Archive. 4. The Triple Star Systems 63 Gem A and HR 2896

DTIC Science & Technology

2010-12-01

3450 Massachusetts Avenue, NW, Washington, DC 20392-5420, USA; wih @usno.navy.mil 5 Division of Physics, Mathematics and Astronomy, 105-24, California...presented to aid in constraining the orbit and measuring the stellar masses. In fact, 63 Gem itself is a sextuple system: the hierarchical triple...that mutual inclination measurements have been rare is because of the observational challenges these sys- tems present. RV signals are largest for

Towards Web Service-Based Educational Systems

ERIC Educational Resources Information Center

Sampson, Demetrios G.

2005-01-01

The need for designing the next generation of web service-based educational systems with the ability of integrating components from different tools and platforms is now recognised as the major challenge in advanced learning technologies. In this paper, we discuss this issue and we present the conceptual design of such environment, referred to as…

A Complex Dynamic Systems Perspective on Identity and Its Development: The Dynamic Systems Model of Role Identity

ERIC Educational Resources Information Center

Kaplan, Avi; Garner, Joanna K.

2017-01-01

Current prominent models of identity face challenges in bridging across divergent perspectives and apparent dichotomies such as personal or social-collective, conscious or unconscious, and epigenetic or discursive-relational, and affording pursuit of research questions that allows integrative answers. This article presents a coherent theoretical…

Learning and Organizational Effectiveness: A Systems Perspective

ERIC Educational Resources Information Center

Andreadis, Nicholas

2009-01-01

The challenge for leaders today is to create and develop the capability of their organization. Leaders must perceive and manage their organization as a dynamic, open system where learning is the core competence underlying innovation, growth, and sustainability. Creating a culture of learning is the first work of leadership. This article presents a…

The Construction of the Chinese Academic System: Its History and Present Challenges

ERIC Educational Resources Information Center

Yan, Guangcai

2009-01-01

The rise and development of China's academic system is a process that started from "passively accepting Western Learning" to today's "catching up with Western Learning and even exceeding it". In the last century, China experienced a turbulent and unstable social environment in which academics and politics have always been…

AI challenges for spacecraft control programs

NASA Technical Reports Server (NTRS)

Lightfoot, Patricia

1986-01-01

The application of AI technology to the spacecraft and experiment command and control systems environment is proposed. The disadvantages of the present methods for analyzing and resolving spacecraft experiment command and control problems are discussed. The potential capabilities and advantages of using AI for the spacecraft and experiment command and control systems are described.

System for Training Aviation Regulations (STAR): Using Multiple Vantage Points To Learn Complex Information through Scenario-Based Instruction and Multimedia Techniques.

ERIC Educational Resources Information Center

Chandler, Terrell N.

1996-01-01

The System for Training of Aviation Regulations (STAR) provides comprehensive training in understanding and applying Federal aviation regulations. STAR gives multiple vantage points with multimedia presentations and storytelling within four categories of learning environments: overviews, scenarios, challenges, and resources. Discusses the…

Introduction to Advanced Engine Control Concepts

NASA Technical Reports Server (NTRS)

Sanjay, Garg

2007-01-01

With the increased emphasis on aircraft safety, enhanced performance and affordability, and the need to reduce the environmental impact of aircraft, there are many new challenges being faced by the designers of aircraft propulsion systems. The Controls and Dynamics Branch at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet these challenges through the concept of Intelligent Propulsion Systems. The key enabling technologies for an Intelligent Propulsion System are the increased efficiencies of components through active control, advanced diagnostics and prognostics integrated with intelligent engine control to enhance operational reliability and component life, and distributed control with smart sensors and actuators in an adaptive fault tolerant architecture. This presentation describes the current activities of the Controls and Dynamics Branch in the areas of active component control and propulsion system intelligent control, and presents some recent analytical and experimental results in these areas.

Children with chronic continence problems: the challenges for families.

PubMed

Erickson, David V; Ray, Lynne D

2004-01-01

For families who are raising children with myelomeningocele, bowel and bladder incontinence presents unique challenges for everyday life. The Parenting and Childhood Chronicity model is used to describe the work of raising a child with a chronic condition in 6 areas, including medical care, adapted parenting, dealing with the systems, caring for siblings, maintaining relationships, and personal coping (keeping yourself going). This article provides an overview of the physiologic and developmental challenges inherent in this neural tube defect and illustrates the work that is involved in the child's care and the challenges of maintaining a balance in family life. Clinical implications are discussed, including the setting of appropriate expectations, providing parents with accurate information, ensuring that a focus on continence is not at the expense of other important aspects of the child's functioning, and supporting parents in their interaction with the school system. The medical team, consisting of nursing, urology, nephrology, and psychology working together, can be a strong support for families.

Harnessing the potential of biomaterials for brain repair after stroke

NASA Astrophysics Data System (ADS)

Tuladhar, Anup; Payne, Samantha L.; Shoichet, Molly S.

2018-03-01

Stroke is a devastating disease for which no clinical treatment exists to regenerate lost tissue. Strategies for brain repair in animal models of stroke include the delivery of drug or cell-based therapeutics; however, the complex anatomy and functional organization of the brain presents many challenges. Biomaterials may alleviate some of these challenges by providing a scaffold, localizing the therapy to the site of action, and/or modulating cues to brain cells. Here, the challenges associated with delivery of therapeutics to the brain and the biomaterial strategies used to overcome these challenges are described. For example, innovative hydrogel delivery systems have been designed to provide sustained trophic factor delivery for endogenous repair and to support transplanted cell survival and integration. Novel treatments, such as electrical stimulation of transplanted cells and the delivery of factors for the direct reprogramming of astrocytes into neurons, may be further enhanced by biomaterial delivery systems. Ultimately, improved clinical translation will be achieved by combining clinically relevant therapies with biomaterials strategies.

Technology-mediated therapy for chronic pain management: the challenges of adapting behavior change interventions for delivery with pervasive communication technology.

PubMed

Rosser, Benjamin A; McCullagh, Paul; Davies, Richard; Mountain, Gail A; McCracken, Lance; Eccleston, Christopher

2011-04-01

Adapting therapeutic practice from traditional face-to-face exchange to remote technology-based delivery presents challenges for the therapist, patient, and technical writer. This article documents the process of therapy adaptation and the resultant specification for the SMART2 project-a technology-based self-management system for assisting long-term health conditions, including chronic pain. Focus group discussions with healthcare professionals and patients were conducted to inform selection of therapeutic objectives and appropriate technology. Pertinent challenges are identified, relating to (1) reduction and definition of therapeutic objectives, and (2) how to approach adaptation of therapy to a form suited to technology delivery. The requirement of the system to provide dynamic and intelligent responses to patient experience and behavior is also emphasized. Solutions to these challenges are described in the context of the SMART2 technology-based intervention. More explicit discussion and documentation of therapy adaptation to technology-based delivery within the literature is encouraged.

Streaming of Continuous Media for Distance Education Systems

ERIC Educational Resources Information Center

Dashti, Ali; Safar, Maytham

2007-01-01

Distance education created new challenges regarding the delivery of large size isochronous continuous streaming media (SM) objects. In this paper, we consider the design of a framework for customized SM presentations, where each presentation consists of a number of SM objects that should be retrieved and displayed to the user in a coherent…

Self-Presentation, Interpersonal Perception, and Partner Selection in Computer-Mediated Relationship Formation

ERIC Educational Resources Information Center

Fiore, Andrew Rocco Tresolini

2010-01-01

The use of social and technological intermediaries to seek intimate partners has a long history. Yet the affordances and limitations of modern computer-mediated communication (CMC) systems built for this purpose--specifically, online dating sites--present new challenges and opportunities for those who use them to initiate intimate relationships.…

Responsive systems - The challenge for the nineties

NASA Technical Reports Server (NTRS)

Malek, Miroslaw

1990-01-01

A concept of responsive computer systems will be introduced. The emerging responsive systems demand fault-tolerant and real-time performance in parallel and distributed computing environments. The design methodologies for fault-tolerant, real time and responsive systems will be presented. Novel techniques of introducing redundancy for improved performance and dependability will be illustrated. The methods of system responsiveness evaluation will be proposed. The issues of determinism, closed and open systems will also be discussed from the perspective of responsive systems design.

Intelligent Computational Systems. Opening Remarks: CFD Application Process Workshop

NASA Technical Reports Server (NTRS)

VanDalsem, William R.

1994-01-01

This discussion will include a short review of the challenges that must be overcome if computational physics technology is to have a larger impact on the design cycles of U.S. aerospace companies. Some of the potential solutions to these challenges may come from the information sciences fields. A few examples of potential computational physics/information sciences synergy will be presented, as motivation and inspiration for the Improving The CFD Applications Process Workshop.

Talent management best practices: how exemplary health care organizations create value in a down economy.

PubMed

Groves, Kevin S

2011-01-01

: Difficult economic conditions and powerful workforce trends pose significant challenges to managing talent in health care organizations. Although robust research evidence supports the many benefits of maintaining a strong commitment to talent management practices despite these challenges, many organizations compound the problem by resorting to workforce reductions and limiting or eliminating investments in talent management. : This study examines how nationwide health care systems address these challenges through best practice talent management systems. Addressing important gaps in talent management theory and practice, this study develops a best practice model of talent management that is grounded in the contextual challenges facing health care practitioners. : Utilizing a qualitative case study that examined 15 nationwide health care systems, data were collected through semistructured interviews with 30 executives and document analysis of talent management program materials submitted by each organization. : Exemplary health care organizations employ a multiphased talent management system composed of six sequential phases and associated success factors that drive effective implementation. Based on these findings, a model of talent management best practices in health care organizations is presented. : Health care practitioners may utilize the best practice model to assess and enhance their respective talent management systems by establishing the business case for talent management, defining, identifying, and developing high-potential leaders, carefully communicating high-potential designations, and evaluating talent management outcomes.

Teaching sustainability science from a systems analysis perspective: MSc course at Utrecht University

NASA Astrophysics Data System (ADS)

Santos, Maria J.; de Boer, Hugo; Dekker, Stefan

2017-04-01

Sustainability science has emerged as a key discipline that embraces both disciplinary depth and interdisciplinary breadth. The challenge is to design University courses that convey both properties without sacrificing either of them. Here we present the design of such course at Utrecht University (the Netherlands) for the MSC program 'Sustainable Development' and discuss the perceived learning and student evaluations. Our course (Sustainability Modelling and Indicators (SMI)) follows an introductory course on Sustainability Perspectives. SMI philosophy is that system thinking and system analysis is central to sustainability science. To convey this philosophy, we focus on four themes: the Anthropocene, Food security, Energy security and Agency and decision making. We developed four hands-on assignments with increasing complexity and make use of different software (Stella, Excel, IMAGE and Netlogo). The assignments aimed at: (1) teaching students the system components by using a pre-existing model in Stella, (2) challenge students to build their own coupled system in Excel, (3) assess outputs from the fully-coupled and dynamic model integrated assessment model IMAGE, and (4) understand emergent properties using an agent-based model in Netlogo. Based on detailed student evaluations (n = 95) we found that the mathematics presented a manageable challenge to a part of the students. The student pool identified a priori having higher experience with Excel in comparison with other software. Netlogo was the highest ranked software in the student evaluations and this was linked to its user-interface with moving agents. The Excel assignment received the highest and lowest scores, and students found it challenging, time consuming but also indicated that they learned the most from this assignment. Students graded what we considered 'easy' assignments with the highest grades. These results suggest that a systems analytical approach to sustainability science can be operationalized in diverse ways that relate to students background and making use of of-the-shelf software. The key challenge is to teach students all the concepts of systems analysis and the applied mathematics behind it. If the goal is to demonstrate process, this portfolio approach with of-the-shelf software can be very successful. This course can be complemented with programming that provides skills to modify and customize software to student needs.

Cyber security challenges in Smart Cities: Safety, security and privacy.

PubMed

Elmaghraby, Adel S; Losavio, Michael M

2014-07-01

The world is experiencing an evolution of Smart Cities. These emerge from innovations in information technology that, while they create new economic and social opportunities, pose challenges to our security and expectations of privacy. Humans are already interconnected via smart phones and gadgets. Smart energy meters, security devices and smart appliances are being used in many cities. Homes, cars, public venues and other social systems are now on their path to the full connectivity known as the "Internet of Things." Standards are evolving for all of these potentially connected systems. They will lead to unprecedented improvements in the quality of life. To benefit from them, city infrastructures and services are changing with new interconnected systems for monitoring, control and automation. Intelligent transportation, public and private, will access a web of interconnected data from GPS location to weather and traffic updates. Integrated systems will aid public safety, emergency responders and in disaster recovery. We examine two important and entangled challenges: security and privacy. Security includes illegal access to information and attacks causing physical disruptions in service availability. As digital citizens are more and more instrumented with data available about their location and activities, privacy seems to disappear. Privacy protecting systems that gather data and trigger emergency response when needed are technological challenges that go hand-in-hand with the continuous security challenges. Their implementation is essential for a Smart City in which we would wish to live. We also present a model representing the interactions between person, servers and things. Those are the major element in the Smart City and their interactions are what we need to protect.

Outlet diffusers to increase culvert capacity.

DOT National Transportation Integrated Search

2016-06-01

Aging infrastructure and changing weather patterns present the need to increase the capacity of existing highway culverts. This research approaches this challenge through the use of diffuser outlet systems to increase pipe capacity and reduce outlet ...

A Brief Review on Multivalent Intercalation Batteries with Aqueous Electrolytes

PubMed Central

Guduru, Ramesh K.; Icaza, Juan C.

2016-01-01

Rapidly growing global demand for high energy density rechargeable batteries has driven the research toward developing new chemistries and battery systems beyond Li-ion batteries. Due to the advantages of delivering more than one electron and giving more charge capacity, the multivalent systems have gained considerable attention. At the same time, affordability, ease of fabrication and safety aspects have also directed researchers to focus on aqueous electrolyte based multivalent intercalation batteries. There have been a decent number of publications disclosing capabilities and challenges of several multivalent battery systems in aqueous electrolytes, and while considering an increasing interest in this area, here, we present a brief overview of their recent progress, including electrode chemistries, functionalities and challenges. PMID:28344298

Excited state dynamics of thiophene and bithiophene: new insights into theoretically challenging systems.

PubMed

Prlj, Antonio; Curchod, Basile F E; Corminboeuf, Clémence

2015-06-14

The computational elucidation and proper description of the ultrafast deactivation mechanisms of simple organic electronic units, such as thiophene and its oligomers, is as challenging as it is contentious. A comprehensive excited state dynamics analysis of these systems utilizing reliable electronic structure approaches is currently lacking, with earlier pictures of the photochemistry of these systems being conceived based upon high-level static computations or lower level dynamic trajectories. Here a detailed surface hopping molecular dynamics of thiophene and bithiophene using the algebraic diagrammatic construction to second order (ADC(2)) method is presented. Our findings illustrate that ring puckering plays an important role in thiophene photochemistry and that the photostability increases when going upon dimerization into bithiophene.

Detecting paralinguistic events in audio stream using context in features and probabilistic decisions☆

PubMed Central

Gupta, Rahul; Audhkhasi, Kartik; Lee, Sungbok; Narayanan, Shrikanth

2017-01-01

Non-verbal communication involves encoding, transmission and decoding of non-lexical cues and is realized using vocal (e.g. prosody) or visual (e.g. gaze, body language) channels during conversation. These cues perform the function of maintaining conversational flow, expressing emotions, and marking personality and interpersonal attitude. In particular, non-verbal cues in speech such as paralanguage and non-verbal vocal events (e.g. laughters, sighs, cries) are used to nuance meaning and convey emotions, mood and attitude. For instance, laughters are associated with affective expressions while fillers (e.g. um, ah, um) are used to hold floor during a conversation. In this paper we present an automatic non-verbal vocal events detection system focusing on the detect of laughter and fillers. We extend our system presented during Interspeech 2013 Social Signals Sub-challenge (that was the winning entry in the challenge) for frame-wise event detection and test several schemes for incorporating local context during detection. Specifically, we incorporate context at two separate levels in our system: (i) the raw frame-wise features and, (ii) the output decisions. Furthermore, our system processes the output probabilities based on a few heuristic rules in order to reduce erroneous frame-based predictions. Our overall system achieves an Area Under the Receiver Operating Characteristics curve of 95.3% for detecting laughters and 90.4% for fillers on the test set drawn from the data specifications of the Interspeech 2013 Social Signals Sub-challenge. We perform further analysis to understand the interrelation between the features and obtained results. Specifically, we conduct a feature sensitivity analysis and correlate it with each feature's stand alone performance. The observations suggest that the trained system is more sensitive to a feature carrying higher discriminability with implications towards a better system design. PMID:28713197

GuideLiner™ as guide catheter extension for the unreachable mammary bypass graft.

PubMed

Vishnevsky, Alec; Savage, Michael P; Fischman, David L

2018-03-09

Percutaneous coronary intervention (PCI) of mammary artery bypass grafts through a trans-radial (TR) approach can present unique challenges, including coaxial vessel engagement of the guiding catheter, adequate visualization of the target lesion, sufficient backup support for equipment delivery, and the ability to reach very distal lesions. The GuideLiner catheter, a rapid exchange monorail mother-in-daughter system, facilitates successful interventions in such challenging anatomy. We present a case of a patient undergoing PCI of a right internal mammary artery (RIMA) graft via TR access in whom the graft could not be engaged with any guiding catheter. Using a balloon tracking technique over a guidewire, a GuideLiner was placed as an extension of the guiding catheter and facilitated TR-PCI by overcoming technical challenges associated with difficult anatomy. © 2018 Wiley Periodicals, Inc.

An Overview of Science Challenges Pertaining to our Understanding of Extreme Geomagnetically Induced Currents. Chapter 8

NASA Technical Reports Server (NTRS)

Ngwira, Chigomezyo M.; Pulkkinen, Antti A.

2018-01-01

Vulnerability of man-made infrastructure to Earth-directed space weather events is a serious concern for today's technology-dependent society. Space weather-driven geomagnetically induced currents (GICs) can disrupt operation of extended electrically conducting technological systems. The threat of adverse impacts on critical technological infrastructure, like power grids, oil and gas pipelines, and communication networks, has sparked renewed interest in extreme space weather. Because extreme space weather events have low occurrence rate but potentially high impact, this presents a major challenge for our understanding of extreme GIC activity. In this chapter, we discuss some of the key science challenges pertaining to our understanding of extreme events. In addition, we present an overview of GICs including highlights of severe impacts over the last 80 years and recent U.S. Federal actions relevant to this community.

Green Propulsion Technologies for Advanced Air Transports

NASA Technical Reports Server (NTRS)

Del Rosario, Ruben

2015-01-01

Air transportation is critical to U.S. and Global economic vitality. However, energy and climate issues challenge aviation's ability to be sustainable in the long term. Aviation must dramatically reduce fuel use and related emissions. Energy costs to U.S. airlines nearly tripled between 1995 and 2011, and continue to be the highest percentage of operating costs. The NASA Advanced Air Transports Technology Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advanced technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. The presentation will highlight the NASA vision of revolutionary systems and propulsion technologies needed to achieve these challenging goals. Specifically, the primary focus is on the N+3 generation; that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe.

Real-time scalable visual analysis on mobile devices

NASA Astrophysics Data System (ADS)

Pattath, Avin; Ebert, David S.; May, Richard A.; Collins, Timothy F.; Pike, William

2008-02-01

Interactive visual presentation of information can help an analyst gain faster and better insight from data. When combined with situational or context information, visualization on mobile devices is invaluable to in-field responders and investigators. However, several challenges are posed by the form-factor of mobile devices in developing such systems. In this paper, we classify these challenges into two broad categories - issues in general mobile computing and issues specific to visual analysis on mobile devices. Using NetworkVis and Infostar as example systems, we illustrate some of the techniques that we employed to overcome many of the identified challenges. NetworkVis is an OpenVG-based real-time network monitoring and visualization system developed for Windows Mobile devices. Infostar is a flash-based interactive, real-time visualization application intended to provide attendees access to conference information. Linked time-synchronous visualization, stylus/button-based interactivity, vector graphics, overview-context techniques, details-on-demand and statistical information display are some of the highlights of these applications.

Challenges in large scale quantum mechanical calculations: Challenges in large scale quantum mechanical calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratcliff, Laura E.; Mohr, Stephan; Huhs, Georg

2016-11-07

During the past decades, quantum mechanical methods have undergone an amazing transition from pioneering investigations of experts into a wide range of practical applications, made by a vast community of researchers. First principles calculations of systems containing up to a few hundred atoms have become a standard in many branches of science. The sizes of the systems which can be simulated have increased even further during recent years, and quantum-mechanical calculations of systems up to many thousands of atoms are nowadays possible. This opens up new appealing possibilities, in particular for interdisciplinary work, bridging together communities of different needs andmore » sensibilities. In this review we will present the current status of this topic, and will also give an outlook on the vast multitude of applications, challenges and opportunities stimulated by electronic structure calculations, making this field an important working tool and bringing together researchers of many different domains.« less

Process Algebra Approach for Action Recognition in the Maritime Domain

NASA Technical Reports Server (NTRS)

Huntsberger, Terry

2011-01-01

The maritime environment poses a number of challenges for autonomous operation of surface boats. Among these challenges are the highly dynamic nature of the environment, the onboard sensing and reasoning requirements for obeying the navigational rules of the road, and the need for robust day/night hazard detection and avoidance. Development of full mission level autonomy entails addressing these challenges, coupled with inference of the tactical and strategic intent of possibly adversarial vehicles in the surrounding environment. This paper introduces PACIFIC (Process Algebra Capture of Intent From Information Content), an onboard system based on formal process algebras that is capable of extracting actions/activities from sensory inputs and reasoning within a mission context to ensure proper responses. PACIFIC is part of the Behavior Engine in CARACaS (Cognitive Architecture for Robotic Agent Command and Sensing), a system that is currently running on a number of U.S. Navy unmanned surface and underwater vehicles. Results from a series of experimental studies that demonstrate the effectiveness of the system are also presented.

Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.

PubMed

Hill, A J; Blundell, J E

1990-03-01

The sensitivity of the appetite system of a group of obese individuals was assessed in response to two challenges known to reduce hunger and enhance satiety in lean people. The challenges were the presentation of a caloric (high protein) load and the activation of serotonin systems. Eight obese female adults (BMI = 38) received 2 X 15 mg d-fenfluramine or placebo daily for 3 days, the study conforming to a 2 X 2 factor (drug X lunch type), double blind, repeated measures design. Three hours after dosing on day 3 they ate either a high carbohydrate (63 percent of total energy) or high protein (54 percent) lunchtime meal (the caloric load). These fixed meal challenges were equal in energy (475 kcal), weight and fat content. Ratings of hunger motivation and food preferences were tracked over the course of lunch and for a further 3 hours, at which point subjects returned for a self-selection test meal. Intakes from this second open meal revealed significant main effects of both caloric load and drug on energy intake, with the high protein d-fenfluramine combination being the most potent anorectic pairing. These findings were supported by the profiles of hunger motivation. This study has confirmed that the appetite system of these subjects was responsive to these biologically relevant challenges. The results suggest that the combination of an appetite modulating drug with specific dietary intervention may represent an effective strategy for the management of hunger arising from caloric restriction.

Wind Turbine Drivetrain Reliability Collaborative Workshop: A Recap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Jonathan; Sheng, Shuangwen; Cotrell, Jason

The Wind Turbine Drivetrain Reliability Collaborative Workshop was convened by the National Renewable Energy Laboratory (NREL), Argonne National Laboratory, and the U.S. Department of Energy to explore the state of the art in wind turbine drivetrain mechanical system reliability as well as research and development (R&D) challenges that if solved could have significant benefits. The workshop was held at the Research Support Facility on NREL's main campus in Golden, Colorado, from February 16-17, 2016. More than 120 attendees participated from industry, academia, and government. Plenary presentations covered wind turbine drivetrain design, testing, and analysis; tribology -- the science and engineeringmore » of interacting surfaces in relative motion -- and failure modes; and condition monitoring and data analytics. In addition to the presentations, workshops were held in each of these areas to discuss R&D challenges. This report serves as a summary of the presentations, workshops, and conclusions on R&D challenges in wind turbine drivetrain reliability.« less

An atypical case of neurosarcoidosis presenting with neovascular glaucoma.

PubMed

Vereecken, Melissa; Hollanders, Karolien; De Bruyn, Deborah; Ninclaus, Virginie; De Zaeytijd, Julie; De Schryver, Ilse

2018-04-18

Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative. A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Slit lamp examination revealed anterior chamber cells, iris, and angle neovascularization. Fundoscopy showed a pale edematous optic nerve head surrounded with intraretinal hemorrhages and yellow retinal infiltrates. The vasculature was very narrow to absent. Indeed, fluorescein angiography filling was limited to the (juxta-)papillary region. An extensive systemic work-up revealed a monoclonal gammopathy and absence of any inflammatory markers. On MRI, a mass infiltration of the intraorbital and the intracranial optic nerve was visible. Additional PET-CT scan revealed hilar lymph nodes. A transbronchial biopsy demonstrating a non-caseating granulomatous lesion led to the diagnosis of sarcoidosis and thus neurosarcoidosis. Treatment with high-dose prednisone and azathioprine was started to avoid progression and subsequent visual loss in the other eye. A patient with neurosarcoidosis presenting with compressive ischemic optic disc edema and neovascular glaucoma is described, increasing the diversity of clinical presentations and confirming the diagnostic challenge of neurosarcoidosis.

Establishing the fundamentals for an elephant early warning and monitoring system.

PubMed

Zeppelzauer, Matthias; Stoeger, Angela S

2015-09-04

The decline of habitat for elephants due to expanding human activity is a serious conservation problem. This has continuously escalated the human-elephant conflict in Africa and Asia. Elephants make extensive use of powerful infrasonic calls (rumbles) that travel distances of up to several kilometers. This makes elephants well-suited for acoustic monitoring because it enables detecting elephants even if they are out of sight. In sight, their distinct visual appearance makes them a good candidate for visual monitoring. We provide an integrated overview of our interdisciplinary project that established the scientific fundamentals for a future early warning and monitoring system for humans who regularly experience serious conflict with elephants. We first draw the big picture of an early warning and monitoring system, then review the developed solutions for automatic acoustic and visual detection, discuss specific challenges and present open future work necessary to build a robust and reliable early warning and monitoring system that is able to operate in situ. We present a method for the automated detection of elephant rumbles that is robust to the diverse noise sources present in situ. We evaluated the method on an extensive set of audio data recorded under natural field conditions. Results show that the proposed method outperforms existing approaches and accurately detects elephant rumbles. Our visual detection method shows that tracking elephants in wildlife videos (of different sizes and postures) is feasible and particularly robust at near distances. From our project results we draw a number of conclusions that are discussed and summarized. We clearly identified the most critical challenges and necessary improvements of the proposed detection methods and conclude that our findings have the potential to form the basis for a future automated early warning system for elephants. We discuss challenges that need to be solved and summarize open topics in the context of a future early warning and monitoring system. We conclude that a long-term evaluation of the presented methods in situ using real-time prototypes is the most important next step to transfer the developed methods into practical implementation.

Virtual Inertia: Current Trends and Future Directions

DOE PAGES

Tamrakar, Ujjwol; Shrestha, Dipesh; Maharjan, Manisha; ...

2017-06-26

The modern power system is progressing from a synchronous machine-based system towards an inverter-dominated system, with a large-scale penetration of renewable energy sources (RESs) like wind and photovoltaics. RES units today represent a major share of the generation, and the traditional approach of integrating themas grid following units can lead to frequency instability. Many researchers have pointed towards using inverters with virtual inertia control algorithms so that they appear as synchronous generators to the grid, maintaining and enhancing system stability. Our paper presents a literature review of the current state-of-the-art of virtual inertia implementation techniques, and explores potential research directionsmore » and challenges. The major virtual inertia topologies are compared and classified. Through literature review and simulations of some selected topologies it has been shown that similar inertial response can be achieved by relating the parameters of these topologies through time constants and inertia constants, although the exact frequency dynamics may vary slightly. The suitability of a topology depends on system control architecture and desired level of detail in replication of the dynamics of synchronous generators. We present a discussion on the challenges and research directions which points out several research needs, especially for systems level integration of virtual inertia systems.« less

Virtual Inertia: Current Trends and Future Directions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tamrakar, Ujjwol; Shrestha, Dipesh; Maharjan, Manisha

The modern power system is progressing from a synchronous machine-based system towards an inverter-dominated system, with a large-scale penetration of renewable energy sources (RESs) like wind and photovoltaics. RES units today represent a major share of the generation, and the traditional approach of integrating themas grid following units can lead to frequency instability. Many researchers have pointed towards using inverters with virtual inertia control algorithms so that they appear as synchronous generators to the grid, maintaining and enhancing system stability. Our paper presents a literature review of the current state-of-the-art of virtual inertia implementation techniques, and explores potential research directionsmore » and challenges. The major virtual inertia topologies are compared and classified. Through literature review and simulations of some selected topologies it has been shown that similar inertial response can be achieved by relating the parameters of these topologies through time constants and inertia constants, although the exact frequency dynamics may vary slightly. The suitability of a topology depends on system control architecture and desired level of detail in replication of the dynamics of synchronous generators. We present a discussion on the challenges and research directions which points out several research needs, especially for systems level integration of virtual inertia systems.« less

System-Level Virtualization for High Performance Computing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vallee, Geoffroy R; Naughton, III, Thomas J; Engelmann, Christian

2008-01-01

System-level virtualization has been a research topic since the 70's but regained popularity during the past few years because of the availability of efficient solution such as Xen and the implementation of hardware support in commodity processors (e.g. Intel-VT, AMD-V). However, a majority of system-level virtualization projects is guided by the server consolidation market. As a result, current virtualization solutions appear to not be suitable for high performance computing (HPC) which is typically based on large-scale systems. On another hand there is significant interest in exploiting virtual machines (VMs) within HPC for a number of other reasons. By virtualizing themore » machine, one is able to run a variety of operating systems and environments as needed by the applications. Virtualization allows users to isolate workloads, improving security and reliability. It is also possible to support non-native environments and/or legacy operating environments through virtualization. In addition, it is possible to balance work loads, use migration techniques to relocate applications from failing machines, and isolate fault systems for repair. This document presents the challenges for the implementation of a system-level virtualization solution for HPC. It also presents a brief survey of the different approaches and techniques to address these challenges.« less

Integrating autonomous distributed control into a human-centric C4ISR environment

NASA Astrophysics Data System (ADS)

Straub, Jeremy

2017-05-01

This paper considers incorporating autonomy into human-centric Command, Control, Communications, Computers, Intelligence, Surveillance and Reconnaissance (C4ISR) environments. Specifically, it focuses on identifying ways that current autonomy technologies can augment human control and the challenges presented by additive autonomy. Three approaches to this challenge are considered, stemming from prior work in two converging areas. In the first, the problem is approached as augmenting what humans currently do with automation. In the alternate approach, the problem is approached as treating humans as actors within a cyber-physical system-of-systems (stemming from robotic distributed computing). A third approach, combines elements of both of the aforementioned.

Status, Vision, and Challenges of an Intelligent Distributed Engine Control Architecture

NASA Technical Reports Server (NTRS)

Behbahani, Alireza; Culley, Dennis; Garg, Sanjay; Millar, Richard; Smith, Bert; Wood, Jim; Mahoney, Tim; Quinn, Ronald; Carpenter, Sheldon; Mailander, Bill;

How to Extend the Capabilities of Space Systems for Long Duration Space Exploration Systems

NASA Technical Reports Server (NTRS)

Marzwell, Neville I.; Waterman, Robert D.; KrishnaKumar, Kalmanje; Waterman, Susan J.

2005-01-01

For sustainable Exploration Missions the need exists to assemble systems-of-systems in space, on the Moon or on other planetary surfaces. To fulfill this need new and innovative system architecture is needed that can be satisfied with the present lift capability of existing rocket technology without the added cost of developing a new heavy lift vehicle. To enable ultra-long life missions with minimum redundancy and lighter mass the need exists to develop system soft,i,are and hardware reconfigurability, which enables increasing functionality and multiple use of launched assets while at the same time overcoming any components failures. Also the need exists to develop the ability to dynamically demate and reassemble individual system elements during a mission in order to work around failed hardware or changed mission requirements. Therefore to meet the goals of Space Exploration Missions in hiteroperability and Reconfigurability, many challenges must be addressed to transform the traditional static avionics architecture into architecture with dynamic capabilities. The objective of this paper is to introduce concepts associated with reconfigurable computer systems; review the various needs and challenges associated with reconfigurable avionics space systems; provide an operational example that illustrates the needs applicable to either the Crew Exploration Vehicle or a collection of "Habot like" mobile surface elements; summarize the approaches that address key challenges to acceptance of a Flexible, Intelligent, Modular and Affordable reconfigurable avionics space system.

Square sugars: challenges and synthetic strategies.

PubMed

Hazelard, Damien; Compain, Philippe

2017-05-10

Square sugars (4-membered ring carbohydrate mimetics) are at the intersection of several important topics concerning the recent emergence, in medicinal chemistry, of glycomimetic drugs and small ring systems. Monosaccharide mimetics containing oxetane, azetidine, thiethane or cyclobutane rings present a number of synthetic challenges that are a powerful driving force for innovation in organic synthesis. In addition to the inherent issues associated with 4-membered rings, the high density of functional groups and asymmetric centres found in glycomimetics further complicates the matter and requires efficient stereoselective methodologies. The purpose of this review is to present an overview of the elegant strategies that have been developed to synthesize the different types of square sugars.

Human Planetary Landing System (HPLS) Capability Roadmap NRC Progress Review

NASA Technical Reports Server (NTRS)

Manning, Rob; Schmitt, Harrison H.; Graves, Claude

2005-01-01

Capability Roadmap Team. Capability Description, Scope and Capability Breakdown Structure. Benefits of the HPLS. Roadmap Process and Approach. Current State-of-the-Art, Assumptions and Key Requirements. Top Level HPLS Roadmap. Capability Presentations by Leads. Mission Drivers Requirements. "AEDL" System Engineering. Communication & Navigation Systems. Hypersonic Systems. Super to Subsonic Decelerator Systems. Terminal Descent and Landing Systems. A Priori In-Situ Mars Observations. AEDL Analysis, Test and Validation Infrastructure. Capability Technical Challenges. Capability Connection Points to other Roadmaps/Crosswalks. Summary of Top Level Capability. Forward Work.

The Challenges of Developing a Food System for a Mars Mission

NASA Technical Reports Server (NTRS)

Perchonok, Michele

2008-01-01

This viewgraph presents a review of the development of food systems for the use during a Mars Mission. It review some of the food delivery systems developed for all of the NASA space programs from Mercury, Gemini, and Apollo, to the Space Shuttle, International Space Station. The goals and objectives of the program are to: provide an adequate food system and develop a safe food system, that is nutritious and acceptable to astronauts, and to provide a food system that efficiently balances vehicle resources.

A Geo-Distributed System Architecture for Different Domains

NASA Astrophysics Data System (ADS)

Moßgraber, Jürgen; Middleton, Stuart; Tao, Ran

2013-04-01

The presentation will describe work on the system-of-systems (SoS) architecture that is being developed in the EU FP7 project TRIDEC on "Collaborative, Complex and Critical Decision-Support in Evolving Crises". In this project we deal with two use-cases: Natural Crisis Management (e.g. Tsunami Early Warning) and Industrial Subsurface Development (e.g. drilling for oil). These use-cases seem to be quite different at first sight but share a lot of similarities, like managing and looking up available sensors, extracting data from them and annotate it semantically, intelligently manage the data (big data problem), run mathematical analysis algorithms on the data and finally provide decision support on this basis. The main challenge was to create a generic architecture which fits both use-cases. The requirements to the architecture are manifold and the whole spectrum of a modern, geo-distributed and collaborative system comes into play. Obviously, one cannot expect to tackle these challenges adequately with a monolithic system or with a single technology. Therefore, a system architecture providing the blueprints to implement the system-of-systems approach has to combine multiple technologies and architectural styles. The most important architectural challenges we needed to address are 1. Build a scalable communication layer for a System-of-sytems 2. Build a resilient communication layer for a System-of-sytems 3. Efficiently publish large volumes of semantically rich sensor data 4. Scalable and high performance storage of large distributed datasets 5. Handling federated multi-domain heterogeneous data 6. Discovery of resources in a geo-distributed SoS 7. Coordination of work between geo-distributed systems The design decisions made for each of them will be presented. These developed concepts are also applicable to the requirements of the Future Internet (FI) and Internet of Things (IoT) which will provide services like smart grids, smart metering, logistics and environmental monitoring.

Verification of Faulty Message Passing Systems with Continuous State Space in PVS

NASA Technical Reports Server (NTRS)

Pilotto, Concetta; White, Jerome

2010-01-01

We present a library of Prototype Verification System (PVS) meta-theories that verifies a class of distributed systems in which agent commu nication is through message-passing. The theoretic work, outlined in, consists of iterative schemes for solving systems of linear equations , such as message-passing extensions of the Gauss and Gauss-Seidel me thods. We briefly review that work and discuss the challenges in formally verifying it.

Data Sharing in DHT Based P2P Systems

NASA Astrophysics Data System (ADS)

Roncancio, Claudia; Del Pilar Villamil, María; Labbé, Cyril; Serrano-Alvarado, Patricia

The evolution of peer-to-peer (P2P) systems triggered the building of large scale distributed applications. The main application domain is data sharing across a very large number of highly autonomous participants. Building such data sharing systems is particularly challenging because of the “extreme” characteristics of P2P infrastructures: massive distribution, high churn rate, no global control, potentially untrusted participants... This article focuses on declarative querying support, query optimization and data privacy on a major class of P2P systems, that based on Distributed Hash Table (P2P DHT). The usual approaches and the algorithms used by classic distributed systems and databases for providing data privacy and querying services are not well suited to P2P DHT systems. A considerable amount of work was required to adapt them for the new challenges such systems present. This paper describes the most important solutions found. It also identifies important future research trends in data management in P2P DHT systems.

The challenges of integrating instrumentation with inflatable aerodynamic decelerators

NASA Astrophysics Data System (ADS)

Swanson, Gregory T.; Cassell, Alan M.; Hughes, Stephen J.; Johnson, R. Keith; Calomino, Anthony M.

New Entry, Decent, and Landing (EDL) technologies are being explored to facilitate the landing of high mass vehicles. Current EDL technologies are limited due to mass and volume constraints dictated by launch vehicle fairings. Therefore, past and present technologies are now being considered to provide a mass and volume efficient solution, including Inflatable Aerodynamic Decelerators (IADs). To better define the instrumentation challenges posed by IAD technology development, a survey was conducted to identify valuable measurements for ground and flight testing of the flexible materials and structures used in their design. From this survey many sensing technologies and systems were explored specific to the stacked torus IAD, resulting in a down-selection to the most viable prospects. The majority of these systems, including wireless data acquisition, were then rapid prototyped and evaluated during component level testing to determine the best integration techniques specific to a 3m and 6m diameter stacked toroid IAD. Each sensing system was then integrated in support of the Hypersonic Inflatable Aerodynamic Decelerator ground test campaign. In this paper these IAD instrumentation systems are described along with their challenges in comparison to traditional rigid aeroshell systems. Requirements resulting from the survey are listed and instrumentation integration techniques and data acquisition are discussed.

Clothing Matching for Visually Impaired Persons

PubMed Central

Yuan, Shuai; Tian, YingLi; Arditi, Aries

2012-01-01

Matching clothes is a challenging task for many blind people. In this paper, we present a proof of concept system to solve this problem. The system consists of 1) a camera connected to a computer to perform pattern and color matching process; 2) speech commands for system control and configuration; and 3) audio feedback to provide matching results for both color and patterns of clothes. This system can handle clothes in deficient color without any pattern, as well as clothing with multiple colors and complex patterns to aid both blind and color deficient people. Furthermore, our method is robust to variations of illumination, clothing rotation and wrinkling. To evaluate the proposed prototype, we collect two challenging databases including clothes without any pattern, or with multiple colors and different patterns under different conditions of lighting and rotation. Results reported here demonstrate the robustness and effectiveness of the proposed clothing matching system. PMID:22523465

Light microscopy applications in systems biology: opportunities and challenges

PubMed Central

2013-01-01

Biological systems present multiple scales of complexity, ranging from molecules to entire populations. Light microscopy is one of the least invasive techniques used to access information from various biological scales in living cells. The combination of molecular biology and imaging provides a bottom-up tool for direct insight into how molecular processes work on a cellular scale. However, imaging can also be used as a top-down approach to study the behavior of a system without detailed prior knowledge about its underlying molecular mechanisms. In this review, we highlight the recent developments on microscopy-based systems analyses and discuss the complementary opportunities and different challenges with high-content screening and high-throughput imaging. Furthermore, we provide a comprehensive overview of the available platforms that can be used for image analysis, which enable community-driven efforts in the development of image-based systems biology. PMID:23578051

Technical challenges and future direction for high-efficiency metal hydride thermal energy storage systems

NASA Astrophysics Data System (ADS)

Ward, Patrick A.; Corgnale, Claudio; Teprovich, Joseph A.; Motyka, Theodore; Hardy, Bruce; Sheppard, Drew; Buckley, Craig; Zidan, Ragaiy

2016-04-01

Recently, there has been increasing interest in thermal energy storage (TES) systems for concentrated solar power (CSP) plants, which allow for continuous operation when sunlight is unavailable. Thermochemical energy storage materials have the advantage of much higher energy densities than latent or sensible heat materials. Furthermore, thermochemical energy storage systems based on metal hydrides have been gaining great interest for having the advantage of higher energy densities, better reversibility, and high enthalpies. However, in order to achieve higher efficiencies desired of a thermal storage system by the US Department of Energy, the system is required to operate at temperatures >600 °C. Operation at temperatures >600 °C presents challenges including material selection, hydrogen embrittlement and permeation of containment vessels, appropriate selection of heat transfer fluids, and cost. Herein, the technical difficulties and proposed solutions associated with the use of metal hydrides as TES materials in CSP applications are discussed and evaluated.

NASA's EOSDIS Cumulus: Ingesting, Archiving, Managing, and Distributing Earth Science Data from the Commercial Cloud

NASA Technical Reports Server (NTRS)

Baynes, Katie; Ramachandran, Rahul; Pilone, Dan; Quinn, Patrick; Gilman, Jason; Schuler, Ian; Jazayeri, Alireza

2017-01-01

NASA's Earth Observing System Data and Information System (EOSDIS) has been working towards a vision of a cloud-based, highly-flexible, ingest, archive, management, and distribution system for its ever-growing and evolving data holdings. This system, Cumulus, is emerging from its prototyping stages and is poised to make a huge impact on how NASA manages and disseminates its Earth science data. This talk will outline the motivation for this work, present the achievements and hurdles of the past 18 months and will chart a course for the future expansion of the Cumulus expansion. We will explore on not just the technical, but also the socio-technical challenges that we face in evolving a system of this magnitude into the cloud and how we are rising to meet those challenges through open collaboration and intentional stakeholder engagement.

A Plan for Revolutionary Change in Gas Turbine Engine Control System Architecture

NASA Technical Reports Server (NTRS)

Culley, Dennis E.

2011-01-01

The implementation of Distributed Engine Control technology on the gas turbine engine has been a vexing challenge for the controls community. A successful implementation requires the resolution of multiple technical issues in areas such as network communications, power distribution, and system integration, but especially in the area of high temperature electronics. Impeding the achievement has been the lack of a clearly articulated message about the importance of the distributed control technology to future turbine engine system goals and objectives. To resolve these issues and bring the technology to fruition has, and will continue to require, a broad coalition of resources from government, industry, and academia. This presentation will describe the broad challenges facing the next generation of advanced control systems and the plan which is being put into action to successfully implement the technology on the next generation of gas turbine engine systems.

Clothing Matching for Visually Impaired Persons.

PubMed

Yuan, Shuai; Tian, Yingli; Arditi, Aries

2011-01-01

Matching clothes is a challenging task for many blind people. In this paper, we present a proof of concept system to solve this problem. The system consists of 1) a camera connected to a computer to perform pattern and color matching process; 2) speech commands for system control and configuration; and 3) audio feedback to provide matching results for both color and patterns of clothes. This system can handle clothes in deficient color without any pattern, as well as clothing with multiple colors and complex patterns to aid both blind and color deficient people. Furthermore, our method is robust to variations of illumination, clothing rotation and wrinkling. To evaluate the proposed prototype, we collect two challenging databases including clothes without any pattern, or with multiple colors and different patterns under different conditions of lighting and rotation. Results reported here demonstrate the robustness and effectiveness of the proposed clothing matching system.

Traffic Flow Management Wrap-Up

NASA Technical Reports Server (NTRS)

Grabbe, Shon

2011-01-01

Traffic Flow Management involves the scheduling and routing of air traffic subject to airport and airspace capacity constraints, and the efficient use of available airspace. Significant challenges in this area include: (1) weather integration and forecasting, (2) accounting for user preferences in the Traffic Flow Management decision making process, and (3) understanding and mitigating the environmental impacts of air traffic on the environment. To address these challenges, researchers in the Traffic Flow Management area are developing modeling, simulation and optimization techniques to route and schedule air traffic flights and flows while accommodating user preferences, accounting for system uncertainties and considering the environmental impacts of aviation. This presentation will highlight some of the major challenges facing researchers in this domain, while also showcasing recent innovations designed to address these challenges.

Wireless Monitoring for Patients with Cardiovascular Diseases and Parkinson's Disease.

PubMed

Kefaliakos, Antonios; Pliakos, Ioannis; Charalampidou, Martha; Diomidous, Marianna

2016-01-01

The use of applications for mobile devices and wireless sensors is common for the sector of telemedicine. Recently various studies and systems were developed in order to help patients suffering from severe diseases such as cardiovascular diseases and Parkinson's disease. They present a challenge for the sector because such systems demand the flow of accurate data in real time and the use of specialized sensors. In this review will be presented some very interesting applications developed for patients with cardiovascular diseases and Parkinson's disease.

Applications of Optical Fiber Assemblies in Harsh Environments, the Journey Past, Present and Future

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; LaRocca, Frank; Thomas, William Joe; Switzer, Robert; Chuska, Richard; Macmurphy, Shawn

2008-01-01

Over the past ten years, NASA has studied the effects of harsh environments on optical fiber assemblies for communication systems, lidar systems, and science missions. The culmination of this has resulted in recent technologies that are unique and tailored to meeting difficult requirements under challenging performance constraints. This presentation will focus on the past mission applications of optical fiber assemblies including; qualification information, lessons learned and new technological advances that will enable the road ahead.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horowitz, Kelsey A; Ding, Fei; Mather, Barry A

This presentation was given at the 2017 NREL Workshop 'Benchmarking Distribution Grid Integration Costs Under High Distributed PV Penetrations.' It provides a brief overview of recent and ongoing NREL work on distribution system grid integration costs, as well as challenges and needs from the community.

Ofsted Inspection as Existential Threat

ERIC Educational Resources Information Center

Richards, Colin

2018-01-01

This article exposes the fear that is at the heart of the Ofsted inspection process. It presents a challenge to Ofsted's Chief Inspector, Amanda Spielman. She must tread carefully if she is to reform Ofsted and our broken accountability system.

Design of a rear anamorphic attachment for digital cinematography

NASA Astrophysics Data System (ADS)

Cifuentes, A.; Valles, A.

2008-09-01

Digital taking systems for HDTV and now for the film industry present a particularly challenging design problem for rear adapters in general. The thick 3-channel prism block in the camera provides an important challenge in the design. In this paper the design of a 1.33x rear anamorphic attachment is presented. The new design departs significantly from the traditional Bravais condition due to the thick dichroic prism block. Design strategies for non-rotationally symmetric systems and fields of view are discussed. Anamorphic images intrinsically have a lower contrast and less resolution than their rotationally symmetric counterparts, therefore proper image evaluation must be considered. The interpretation of the traditional image quality methods applied to anamorphic images is also discussed in relation to the design process. The final design has a total track less than 50 mm, maintaining the telecentricity of the digital prime lens and taking full advantage of the f/1.4 prism block.

A haptic interface for virtual simulation of endoscopic surgery.

PubMed

Rosenberg, L B; Stredney, D

1996-01-01

Virtual reality can be described as a convincingly realistic and naturally interactive simulation in which the user is given a first person illusion of being immersed within a computer generated environment While virtual reality systems offer great potential to reduce the cost and increase the quality of medical training, many technical challenges must be overcome before such simulation platforms offer effective alternatives to more traditional training means. A primary challenge in developing effective virtual reality systems is designing the human interface hardware which allows rich sensory information to be presented to users in natural ways. When simulating a given manual procedure, task specific human interface requirements dictate task specific human interface hardware. The following paper explores the design of human interface hardware that satisfies the task specific requirements of virtual reality simulation of Endoscopic surgical procedures. Design parameters were derived through direct cadaver studies and interviews with surgeons. Final hardware design is presented.

Directing solar photons to sustainably meet food, energy, and water needs.

PubMed

Gençer, Emre; Miskin, Caleb; Sun, Xingshu; Khan, M Ryyan; Bermel, Peter; Alam, M Ashraf; Agrawal, Rakesh

2017-06-09

As we approach a "Full Earth" of over ten billion people within the next century, unprecedented demands will be placed on food, energy and water (FEW) supplies. The grand challenge before us is to sustainably meet humanity's FEW needs using scarcer resources. To overcome this challenge, we propose the utilization of the entire solar spectrum by redirecting solar photons to maximize FEW production from a given land area. We present novel solar spectrum unbundling FEW systems (SUFEWS), which can meet FEW needs locally while reducing the overall environmental impact of meeting these needs. The ability to meet FEW needs locally is critical, as significant population growth is expected in less-developed areas of the world. The proposed system presents a solution to harness the same amount of solar products (crops, electricity, and purified water) that could otherwise require ~60% more land if SUFEWS were not used-a major step for Full Earth preparedness.

Ground Truth Creation for Complex Clinical NLP Tasks - an Iterative Vetting Approach and Lessons Learned.

PubMed

Liang, Jennifer J; Tsou, Ching-Huei; Devarakonda, Murthy V

2017-01-01

Natural language processing (NLP) holds the promise of effectively analyzing patient record data to reduce cognitive load on physicians and clinicians in patient care, clinical research, and hospital operations management. A critical need in developing such methods is the "ground truth" dataset needed for training and testing the algorithms. Beyond localizable, relatively simple tasks, ground truth creation is a significant challenge because medical experts, just as physicians in patient care, have to assimilate vast amounts of data in EHR systems. To mitigate potential inaccuracies of the cognitive challenges, we present an iterative vetting approach for creating the ground truth for complex NLP tasks. In this paper, we present the methodology, and report on its use for an automated problem list generation task, its effect on the ground truth quality and system accuracy, and lessons learned from the effort.

Brush Seals for Improved Steam Turbine Performance

NASA Technical Reports Server (NTRS)

Turnquist, Norman; Chupp, Ray; Baily, Fred; Burnett, Mark; Rivas, Flor; Bowsher, Aaron; Crudgington, Peter

2006-01-01

GE Energy has retrofitted brush seals into more than 19 operating steam turbines. Brush seals offer superior leakage control compared to labyrinth seals, owing to their compliant nature and ability to maintain very tight clearances to the rotating shaft. Seal designs have been established for steam turbines ranging in size from 12 MW to over 1200 MW, including fossil, nuclear, combined-cycle and industrial applications. Steam turbines present unique design challenges that must be addressed to ensure that the potential performance benefits of brush seals are realized. Brush seals can have important effects on the overall turbine system that must be taken into account to assure reliable operation. Subscale rig tests are instrumental to understanding seal behavior under simulated steam-turbine operating conditions, prior to installing brush seals in the field. This presentation discusses the technical challenges of designing brush seals for steam turbines; subscale testing; performance benefits of brush seals; overall system effects; and field applications.

Towards sustainable and multifunctional agriculture in farmland landscapes: Lessons from the integrative approach of a French LTSER platform.

PubMed

Bretagnolle, Vincent; Berthet, Elsa; Gross, Nicolas; Gauffre, Bertrand; Plumejeaud, Christine; Houte, Sylvie; Badenhausser, Isabelle; Monceau, Karine; Allier, Fabrice; Monestiez, Pascal; Gaba, Sabrina

2018-06-15

Agriculture is currently facing unprecedented challenges: ensuring food, fiber and energy production in the face of global change, maintaining the economic performance of farmers and preserving natural resources such as biodiversity and associated key ecosystem services for sustainable agriculture. Addressing these challenges requires innovative landscape scale farming systems that account for changing economic and environmental targets. These novel agricultural systems need to be recognized, accepted and promoted by all stakeholders, including local residents, and supported by public policies. Agroecosystems should be considered as socio-ecological systems and alternative farming systems should be based on ecological principles while taking societal needs into account. This requires an in-depth knowledge of the multiple interactions between sociological and ecological dynamics. Long Term Socio-Ecological Research platforms (LTSER) are ideal for acquiring this knowledge as they (i) are not constrained by traditional disciplinary boundaries, (ii) operate at a large spatial scale involving all stakeholders, and (iii) use systemic approaches to investigate biodiversity and ecosystem services. This study presents the socio-ecological research strategy from the LTSER "Zone Atelier Plaine & Val de Sèvre" (ZA PVS), a large study area where data has been sampled since 1994. Its global aim is to identify effective solutions for agricultural development and the conservation of biodiversity in farmlands. Three main objectives are targeted by the ZAPVS. The first objective is intensive monitoring of landscape features, the main taxa present and agricultural practices. The second objective is the experimental investigation, in real fields with local farmers, of important ecosystem functions and services, in relation to pesticide use, crop production and farming socio-economic value. The third aim is to involve stakeholders through participatory research, citizen science and the dissemination of scientific results. This paper underlines the relevance of LTSERs for addressing agricultural challenges, while acknowledging that there are some yet unsolved key challenges. Copyright © 2018 Elsevier B.V. All rights reserved.

Automatic exposure for panoramic systems in uncontrolled lighting conditions: a football stadium case study

NASA Astrophysics Data System (ADS)

Gaddam, Vamsidhar Reddy; Griwodz, Carsten; Halvorsen, Pâl.

2014-02-01

One of the most common ways of capturing wide eld-of-view scenes is by recording panoramic videos. Using an array of cameras with limited overlapping in the corresponding images, one can generate good panorama images. Using the panorama, several immersive display options can be explored. There is a two fold synchronization problem associated to such a system. One is the temporal synchronization, but this challenge can easily be handled by using a common triggering solution to control the shutters of the cameras. The other synchronization challenge is the automatic exposure synchronization which does not have a straight forward solution, especially in a wide area scenario where the light conditions are uncontrolled like in the case of an open, outdoor football stadium. In this paper, we present the challenges and approaches for creating a completely automatic real-time panoramic capture system with a particular focus on the camera settings. One of the main challenges in building such a system is that there is not one common area of the pitch that is visible to all the cameras that can be used for metering the light in order to nd appropriate camera parameters. One approach we tested is to use the green color of the eld grass. Such an approach provided us with acceptable results only in limited light conditions.A second approach was devised where the overlapping areas between adjacent cameras are exploited, thus creating pairs of perfectly matched video streams. However, there still existed some disparity between di erent pairs. We nally developed an approach where the time between two temporal frames is exploited to communicate the exposures among the cameras where we achieve a perfectly synchronized array. An analysis of the system and some experimental results are presented in this paper. In summary, a pilot-camera approach running in auto-exposure mode and then distributing the used exposure values to the other cameras seems to give best visual results.

Advanced Environmental Barrier Coating Development for SiC-SiC Ceramic Matrix Composite Components

NASA Technical Reports Server (NTRS)

Zhu, Dongming; Harder, Bryan; Bhatt, Ramakrishna; Kiser, Doug; Wiesner, Valerie L.

2016-01-01

This presentation reviews the NASA advanced environmental barrier coating (EBC) system development for SiCSiC Ceramic Matrix Composite (CMC) components for next generation turbine engines. The emphasis has been placed on the current design challenges of the 2700F environmental barrier coatings; coating processing and integration with SiCSiC CMCs and component systems; and performance evaluation and demonstration of EBC-CMC systems. This presentation also highlights the EBC-CMC system temperature capability and durability improvements through advanced compositions and architecture designs, as shown in recent simulated engine high heat flux, combustion environment, in conjunction with mechanical creep and fatigue loading testing conditions.

Rate-programming of nano-particulate delivery systems for smart bioactive scaffolds in tissue engineering.

PubMed

Izadifar, Mohammad; Haddadi, Azita; Chen, Xiongbiao; Kelly, Michael E

2015-01-09

Development of smart bioactive scaffolds is of importance in tissue engineering, where cell proliferation, differentiation and migration within scaffolds can be regulated by the interactions between cells and scaffold through the use of growth factors (GFs) and extra cellular matrix peptides. One challenge in this area is to spatiotemporally control the dose, sequence and profile of release of GFs so as to regulate cellular fates during tissue regeneration. This challenge would be addressed by rate-programming of nano-particulate delivery systems, where the release of GFs via polymeric nanoparticles is controlled by means of the methods of, such as externally-controlled and physicochemically/architecturally-modulated so as to mimic the profile of physiological GFs. Identifying and understanding such factors as the desired release profiles, mechanisms of release, physicochemical characteristics of polymeric nanoparticles, and externally-triggering stimuli are essential for designing and optimizing such delivery systems. This review surveys the recent studies on the desired release profiles of GFs in various tissue engineering applications, elucidates the major release mechanisms and critical factors affecting release profiles, and overviews the role played by the mathematical models for optimizing nano-particulate delivery systems. Potentials of stimuli responsive nanoparticles for spatiotemporal control of GF release are also presented, along with the recent advances in strategies for spatiotemporal control of GF delivery within tissue engineered scaffolds. The recommendation for the future studies to overcome challenges for developing sophisticated particulate delivery systems in tissue engineering is discussed prior to the presentation of conclusions drawn from this paper.

Packaging Technologies for 500 C SiC Electronics and Sensors: Challenges in Material Science and Technology

NASA Technical Reports Server (NTRS)

Chen, Liang-Yu; Neudeck, Philip G.; Behelm, Glenn M.; Spry, David J.; Meredith, Roger D.; Hunter, Gary W.

2015-01-01

This paper presents ceramic substrates and thick-film metallization based packaging technologies in development for 500C silicon carbide (SiC) electronics and sensors. Prototype high temperature ceramic chip-level packages and printed circuit boards (PCBs) based on ceramic substrates of aluminum oxide (Al2O3) and aluminum nitride (AlN) have been designed and fabricated. These ceramic substrate-based chip-level packages with gold (Au) thick-film metallization have been electrically characterized at temperatures up to 550C. The 96 alumina packaging system composed of chip-level packages and PCBs has been successfully tested with high temperature SiC discrete transistor devices at 500C for over 10,000 hours. In addition to tests in a laboratory environment, a SiC junction field-effect-transistor (JFET) with a packaging system composed of a 96 alumina chip-level package and an alumina printed circuit board was tested on low earth orbit for eighteen months via a NASA International Space Station experiment. In addition to packaging systems for electronics, a spark-plug type sensor package based on this high temperature interconnection system for high temperature SiC capacitive pressure sensors was also developed and tested. In order to further significantly improve the performance of packaging system for higher packaging density, higher operation frequency, power rating, and even higher temperatures, some fundamental material challenges must be addressed. This presentation will discuss previous development and some of the challenges in material science (technology) to improve high temperature dielectrics for packaging applications.

The promise of e-health--a Canadian perspective.

PubMed

Alvarez, Richard C

2004-01-01

Canadians value their health care system above any other social programme. Canada's system of health care faces significant financial and population pressures, relating to cost, access, quality, accountability, and the intergration of information and communication technologies (ICTs). The health-system also faces certain unique challenges that include care delivery within a highly decentralised system of financing and accountability, and care delivery to a significant portion of the population sparsely distributed across a land mass of 10 million square kilometres, in areas of extreme climatic conditions. All of these challenges are significant catalysts in the development of technologies that aim to significantly mitigate or eliminate these selfsame challenges. The system is undergoing widespread review, nationally and within each province and territory, where the bulk of care provision is financed and managed. The challenges are being addressed by national, regional and provincial initiatives in the public, private and not-for-profit sectors. The promise of e-health lies in the manner and degree to which it can mitigate or resolve these challenges to the health system and build on advancements in ICTs supporting the development of a health infostructure. Canada is actively developing and implementing technological solutions to deliver health information and health care services across the country. These solutions, while exciting and promising, also present new challenges, particularly in regard to acceptable standards, choice of technologies, overcoming traditional jurisdictional boundaries, up-front investment, and privacy and confidentiality. Many organizations and governments are working to address these challenges. Canada Health Infoway, a not-for-profit corporation, was founded by the first ministers in 2001 to accelerate the establishment of an interoperable, pan-Canadian electronic health record. It works with partners in the federal, provincial and territorial jurisdictions to define replicable solutions for establishment of the major elements necessary to achieve this goal. The Canadian Institute for Health Information (CIHI) will also continue to play an increasingly significant role in these initiatives, as the management of health information becomes a more crucial factor in the successful delivery of health care services in the new millennium.

Ethics Leadership in Research, Healthcare and Organizational Systems: Commentary and Critical Reflections

ERIC Educational Resources Information Center

Gabriele, Edward F.

2011-01-01

In the last decades there has arisen a greater awareness of the ever present need for critical academic reflection on the nature of ethics leadership and committees in research, healthcare, and organizational systems. Yet what is meant by ethics itself? How is ethics understood as a historical phenomenon? What challenges must ethics leaders face…

Life in the Cloud: A WorldShare Management Services Case Study

ERIC Educational Resources Information Center

Hartman, Robin R.

2012-01-01

A small, private academic library took the risk of moving from a traditional integrated library system to adopting a system "in the cloud." This case study presents the setting, history, and local needs of the library, including staffing challenges, and explains the decision-making rationale and process. A description of the library's transition…

A Leadership Opportunity for School Social Workers: Bridging the Gaps in School Reentry for Juvenile Justice System Youths

ERIC Educational Resources Information Center

Goldkind, Lauri

2011-01-01

Social work is frequently missing when policy and practice conversations turn to juvenile justice system youths. However, school social workers are well positioned to have a vital role in the readmission and reentry process for these young people. Formerly incarcerated youths present unique challenges for themselves, their families, and…

Lessons from German and American Industrial-Education Partnerships.

ERIC Educational Resources Information Center

Theuerkauf, Walter E.; Putnam, A. R.

The search for a work force preparation model that could serve as a guide for meeting present and emerging challenges has lead to a focus on the German dual system youth apprenticeship model. In this system, the practice-oriented part is taken over by commercial enterprises and theoretical knowledge is imparted by vocational schools. The trainee…

Note-Taking within MetaTutor: Interactions between an Intelligent Tutoring System and Prior Knowledge on Note-Taking and Learning

ERIC Educational Resources Information Center

Trevors, Gregory; Duffy, Melissa; Azevedo, Roger

2014-01-01

Hypermedia learning environments (HLE) unevenly present new challenges and opportunities to learning processes and outcomes depending on learner characteristics and instructional supports. In this experimental study, we examined how one such HLE--MetaTutor, an intelligent, multi-agent tutoring system designed to scaffold cognitive and…

Using a Recommendation System to Support Problem Solving and Case-Based Reasoning Retrieval

ERIC Educational Resources Information Center

Tawfik, Andrew A.; Alhoori, Hamed; Keene, Charles Wayne; Bailey, Christian; Hogan, Maureen

2018-01-01

In case library learning environments, learners are presented with an array of narratives that can be used to guide their problem solving. However, according to theorists, learners struggle to identify and retrieve the optimal case to solve a new problem. Given the challenges novice face during case retrieval, recommender systems can be embedded…

Measuring Engagement as Students Learn Dynamic Systems and Control with a Video Game

ERIC Educational Resources Information Center

Coller, B. D.; Shernoff, David J.; Strati, Anna

2011-01-01

The paper presents results of a multi-year quasi-experimental study of student engagement during which a video game was introduced into an undergraduate dynamic systems and control course. The video game, "EduTorcs", provided challenges in which students devised control algorithms that drive virtual cars and ride virtual bikes through a…

Innovations in afforestation of agricultural bottomlands to restore native forests in the United States

Treesearch

D.C. Dey; E.S. Gardiner; J.M. Kabrick; J.A. Stanturf; D.F. Jacobs

2010-01-01

Establishing trees in agricultural bottomlands is challenging because of intense competition, flooding and herbivory. A summary is presented of new practices and management systems for regenerating trees in former agricultural fields in the eastern USA. Innovations have come from improvements in planting stock and new silvicultural systems that restore ecological...

Innovations in afforestation of agricultural bottomlands to restore native forests in the eastern USA

Treesearch

Daniel C. Dey; Emile S. Gardiner; John M. Kabrick; John A. Stanturf; Douglass F. Jacobs

2010-01-01

Establishing trees in agricultural bottomlands is challenging because of intense competition, flooding and herbivory. A summary is presented of new practices and management systems for regenerating trees in former agricultural fields in the eastern USA. Innovations have come from improvements in planting stock and new silvicultural systems that restore ecological...

Using iKidTools™ Software Support Systems to Develop and Implement Self-Monitoring Interventions

ERIC Educational Resources Information Center

Patti, Angela L.; Miller, Kevin J.

2011-01-01

Educational teams often are faced with the task of developing and implementing Behavioral Intervention Plans (BIPs) for students who present challenging and/or disruptive behaviors. This article describes the steps used to develop and implement a self-monitoring BIP that incorporated an innovative software system, iKidTools™. An authentic case…

Treatment with Youth Who Have Committed Sexual Offences: Extending the Reach of Systemic Interventions through Collaborative Partnerships

ERIC Educational Resources Information Center

Smallbone, Stephen; Rayment-McHugh, Susan; Crissman, Belinda; Shumack, Danielle

2008-01-01

Delivery of high-quality mental health services to clients in regional and remote areas in Australia presents significant challenges. Griffith Youth Forensic Service (GYFS) provides specialised, state-wide assessment and systemic treatment services for young people in Queensland who have committed sexual offences. In an effort to provide…

Emerging themes in the ecology and management of North American forests

Treesearch

Terry L. Sharik; William Adair; Fred A. Baker; Michael Battaglia; Emily J. Comfort; Anthony W. D' Amato; Craig Delong; R. Justin DeRose; Mark J. Ducey; Mark Harmon; Louise Levy; Jesse A. Logan; Joseph O' Brien; Brian J. Palik; Scott D. Roberts; Paul C. Rogers; Douglas J. Shinneman; Thomas Spies; Sarah L. Taylor; Christopher Woodall; Andrew Youngblood

2010-01-01

Forests are extremely complex systems that respond to an overwhelming number of biological and environmental factors, which can act singularly and in concert with each other, as exemplified by Puettmann et al. [1]. The complexity of forest systems presents an enormous challenge for forest researchers who try to deepen their understanding of the structure and function...

Neonatal Graves' Disease with Maternal Hypothyroidism.

PubMed

Akangire, Gangaram; Cuna, Alain; Lachica, Charisse; Fischer, Ryan; Raman, Sripriya; Sampath, Venkatesh

2017-07-01

Neonatal Graves' disease presenting as conjugated hyperbilirubinemia is a diagnostic challenge because the differential includes a gamut of liver and systemic diseases. We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a mother with hypothyroidism during pregnancy and remote history of Graves' disease. Infant was treated with a combination of methimazole, propranolol, and potassium iodide for 4 weeks. Thyroid function improved after 8 weeks of treatment with full recovery of thyroid function, disappearance of thyroid-stimulating antibodies, and resolution of failure to thrive and conjugated hyperbilirubinemia. This case provides several clinical vignettes as it is a rare, severe, presentation of an uncommon neonatal disease, signs, symptoms, and clinical history presented a diagnostic challenge for neonatologists and endocrinologists, normal newborn screen was misleading, and yet timely treatment led to a full recovery.

The Ascent of Olympus - An Everest Anniversary Perspective

NASA Astrophysics Data System (ADS)

Cockell, C. S.

Olympus Mons, at 21,183 m above the Mars gravitational equipotential, stands just under 2.5 times the height of Mount Everest. Symbolically, as the highest construct in the Solar System, it is the most important feature to be climbed. Despite its powerful symbolism, the mountain presents one of the most tedious long distance expeditions on Mars - a ~300 km journey up a near constant 5 degree slope. Only at the beginning and the end of the expedition do the scarp and caldera cliffs present impressive climbs. In almost all respects Olympus presents environmental challenges much worse than Everest, apart from the lack of fatal storms, perhaps the only environmental factor in which Olympus is an improvement. Similarly to Everest, Olympus presents scien- tific questions of immense interest. In this mini-review I compare Olympus and Everest as exploratory and scientific challenges.

Meeting Early Intervention Challenges: Issues from Birth to Three. Second Edition.

ERIC Educational Resources Information Center

Johnson, Lawrence J., Ed.; And Others

This text presents 12 chapters on the development of coordinated systems of service delivery to infants and toddlers who have disabilities or are at risk for disabilities and their families, as mandated by Part H of the Individuals with Disabilities Education Act (IDEA). An introductory chapter by Lawrence J. Johnson presents a general overview of…

Emergent Frameworks of Research Teaching and Learning in a Cohort-Based Doctoral Programme

ERIC Educational Resources Information Center

Samuel, Michael; Vithal, Renuka

2011-01-01

This article argues that alternate models of doctoral research teaching and learning pedagogy could address the challenge of under-productivity of doctoral graduands in the South African higher education system. Present literature tends not to focus on the models of research teaching and learning as a form of pedagogy. The article presents a case…

Nanoelectronics and More-than-Moore at IMEC

NASA Astrophysics Data System (ADS)

Cartuyvels, Rudi; Biesemans, Serge; Vandervorst, Wilfried; De Boeck, Jo

2011-11-01

This paper presents an overview of imec's R&D addressing the challenges of CMOS scaling towards the 10 nm node and its outlook beyond. In addition to the relentless geometrical shrinks, opportunities to further increase nanoelectronic system functionality and performance by co-integration and chip stacking technologies combined with emerging MEMS and optoelectronic technologies will be presented.

Biomedical engineering strategies in system design space.

PubMed

Savageau, Michael A

2011-04-01

Modern systems biology and synthetic bioengineering face two major challenges in relating properties of the genetic components of a natural or engineered system to its integrated behavior. The first is the fundamental unsolved problem of relating the digital representation of the genotype to the analog representation of the parameters for the molecular components. For example, knowing the DNA sequence does not allow one to determine the kinetic parameters of an enzyme. The second is the fundamental unsolved problem of relating the parameters of the components and the environment to the phenotype of the global system. For example, knowing the parameters does not tell one how many qualitatively distinct phenotypes are in the organism's repertoire or the relative fitness of the phenotypes in different environments. These also are challenges for biomedical engineers as they attempt to develop therapeutic strategies to treat pathology or to redirect normal cellular functions for biotechnological purposes. In this article, the second of these fundamental challenges will be addressed, and the notion of a "system design space" for relating the parameter space of components to the phenotype space of bioengineering systems will be focused upon. First, the concept of a system design space will be motivated by introducing one of its key components from an intuitive perspective. Second, a simple linear example will be used to illustrate a generic method for constructing the design space in which qualitatively distinct phenotypes can be identified and counted, their fitness analyzed and compared, and their tolerance to change measured. Third, two examples of nonlinear systems from different areas of biomedical engineering will be presented. Finally, after giving reference to a few other applications that have made use of the system design space approach to reveal important design principles, some concluding remarks concerning challenges and opportunities for further development will be made.

The Benefits of a Real-Time Web-Based Response System for Enhancing Engaged Learning in Classrooms and Public Science Events.

PubMed

Sarvary, Mark A; Gifford, Kathleen M

2017-01-01

Large introduction to neuroscience classes and small science cafés have the same goal: bridging the gap between the presenter and the audience to convey the information while being engaging. Early classroom response systems became the cornerstone of flipped and engaged learning. These "clickers" helped turn lectures into dialogues, allowing the presenter to become a facilitator rather than a "sage on the stage." Rapid technological developments, especially the increase of computing power opened up new opportunities, moving these systems from a clicker device onto cellphones and laptops. This allowed students to use their own devices, and instructors to use new question types, such as clicking on a picture or ranking concepts. A variety of question types makes the learning environment more engaging, allows better examples for creative and critical thinking, and facilitates assessment. Online access makes these response systems scalable, bringing the strength of formative assessments and surveys to public science communication events, neuroscience journal clubs and distance learning. In addition to the new opportunities, online polling systems also create new challenges for the presenters. For example, allowing mobile devices in the classroom can be distracting. Here, a web-based, real-time response system called Poll Everywhere was compared to iClickers, highlighting the benefits and the pitfalls of both systems. In conclusion, the authors observe that the benefits of web-based response systems outweigh the challenges, and this form of digital pedagogy can help create a rich dialogue with the audience in large classrooms as well as in public science events.

Building a Global Earth Observation System of Systems (GEOSS) and Its Interoperability Challenges

NASA Astrophysics Data System (ADS)

Ryan, B. J.

2015-12-01

Launched in 2005 by industrialized nations, the Group on Earth Observations (GEO) began building the Global Earth Observation System of Systems (GEOSS). Consisting of both a policy framework, and an information infrastructure, GEOSS, was intended to link and/or integrate the multitude of Earth observation systems, primarily operated by its Member Countries and Participating Organizations, so that users could more readily benefit from global information assets for a number of society's key environmental issues. It was recognized that having ready access to observations from multiple systems was a prerequisite for both environmental decision-making, as well as economic development. From the very start, it was also recognized that the shear complexity of the Earth's system cannot be captured by any single observation system, and that a federated, interoperable approach was necessary. While this international effort has met with much success, primarily in advancing broad, open data policies and practices, challenges remain. In 2014 (Geneva, Switzerland) and 2015 (Mexico City, Mexico), Ministers from GEO's Member Countries, including the European Commission, came together to assess progress made during the first decade (2005 to 2015), and approve implementation strategies and mechanisms for the second decade (2016 to 2025), respectively. The approved implementation strategies and mechanisms are intended to advance GEOSS development thereby facilitating the increased uptake of Earth observations for informed decision-making. Clearly there are interoperability challenges that are technological in nature, and several will be discussed in this presentation. There are, however, interoperability challenges that can be better characterized as economic, governmental and/or political in nature, and these will be discussed as well. With the emergence of the Sustainable Development Goals (SDGs), the World Conference on Disaster Risk Reduction (WCDRR), and the United Nations Framework Convention on Climate Change (UNFCCC) having occurred this year, it will be essential that the interoperability challenges described herein, regardless of their nature, be expeditiously addressed so that Earth observations can indeed inform societal decision-making.

Performance evaluation of the use of photovoltaics to power a street light in Lowell

NASA Astrophysics Data System (ADS)

Crowell, Adam B.

Commercial, off-grid photovoltaic (PV) lighting systems present an attractive alternative to traditional outdoor lighting at sites where grid power is unavailable or unreliable. This study presents a comprehensive theoretical site analysis for the installation of standalone PV lighting systems at the Lowell National Historic Park in Lowell, MA. Detailed insolation studies are performed at the target site, resulting in expected daily Watt-hour totals available for battery charging for each month of the year. Illumination simulations are presented, detailing the expected lighting performance of the systems at night. Light levels are compared to those dictated by accepted standards. While it is acknowledged that the target site presents significant challenges to photovoltaics, such as severe shading, final system component specifications are provided, along with programming and positioning recommendations that will yield the best achievable performance.

A Distributed Architecture for Tsunami Early Warning and Collaborative Decision-support in Crises

NASA Astrophysics Data System (ADS)

Moßgraber, J.; Middleton, S.; Hammitzsch, M.; Poslad, S.

2012-04-01

The presentation will describe work on the system architecture that is being developed in the EU FP7 project TRIDEC on "Collaborative, Complex and Critical Decision-Support in Evolving Crises". The challenges for a Tsunami Early Warning System (TEWS) are manifold and the success of a system depends crucially on the system's architecture. A modern warning system following a system-of-systems approach has to integrate various components and sub-systems such as different information sources, services and simulation systems. Furthermore, it has to take into account the distributed and collaborative nature of warning systems. In order to create an architecture that supports the whole spectrum of a modern, distributed and collaborative warning system one must deal with multiple challenges. Obviously, one cannot expect to tackle these challenges adequately with a monolithic system or with a single technology. Therefore, a system architecture providing the blueprints to implement the system-of-systems approach has to combine multiple technologies and architectural styles. At the bottom layer it has to reliably integrate a large set of conventional sensors, such as seismic sensors and sensor networks, buoys and tide gauges, and also innovative and unconventional sensors, such as streams of messages from social media services. At the top layer it has to support collaboration on high-level decision processes and facilitates information sharing between organizations. In between, the system has to process all data and integrate information on a semantic level in a timely manner. This complex communication follows an event-driven mechanism allowing events to be published, detected and consumed by various applications within the architecture. Therefore, at the upper layer the event-driven architecture (EDA) aspects are combined with principles of service-oriented architectures (SOA) using standards for communication and data exchange. The most prominent challenges on this layer include providing a framework for information integration on a syntactic and semantic level, leveraging distributed processing resources for a scalable data processing platform, and automating data processing and decision support workflows.

Competing power-generating technologies for the 21st century

NASA Astrophysics Data System (ADS)

Troost, G. K.

1994-04-01

Several new and advanced power-generating systems are presently being developed, e.g., fuel cells, advanced heat pumps, high-performance gas turbines. An analysis of these systems is presented and is based on projections of comparative studies and relevant trends. For advanced systems, a trade-off between efficiency gain and projected development cost is crucial. Projections for market conditions in the 21st century and, in particular, environmental issues are made in order to assess market-entry opportunities. Results from various case studies indicate challenging opportunities in process and metallurgical industries; several process-integrated configurations are being studied.

Scaffold Translation: Barriers Between Concept and Clinic

PubMed Central

Murphy, William L.

2011-01-01

Translation of scaffold-based bone tissue engineering (BTE) therapies to clinical use remains, bluntly, a failure. This dearth of translated tissue engineering therapies (including scaffolds) remains despite 25 years of research, research funding totaling hundreds of millions of dollars, over 12,000 papers on BTE and over 2000 papers on BTE scaffolds alone in the past 10 years (PubMed search). Enabling scaffold translation requires first an understanding of the challenges, and second, addressing the complete range of these challenges. There are the obvious technical challenges of designing, manufacturing, and functionalizing scaffolds to fill the Form, Fixation, Function, and Formation needs of bone defect repair. However, these technical solutions should be targeted to specific clinical indications (e.g., mandibular defects, spine fusion, long bone defects, etc.). Further, technical solutions should also address business challenges, including the need to obtain regulatory approval, meet specific market needs, and obtain private investment to develop products, again for specific clinical indications. Finally, these business and technical challenges present a much different model than the typical research paradigm, presenting the field with philosophical challenges in terms of publishing and funding priorities that should be addressed as well. In this article, we review in detail the technical, business, and philosophical barriers of translating scaffolds from Concept to Clinic. We argue that envisioning and engineering scaffolds as modular systems with a sliding scale of complexity offers the best path to addressing these translational challenges. PMID:21902613

Unleashing Lessons: Sharing Stories About the Fine Art of Systems Engineering

NASA Technical Reports Server (NTRS)

Singer, Christopher E.

2010-01-01

NASA leaders have a responsibility to share their unique oral histories with junior-level employees on whom NASA's future depends. This presentation will give a few examples of how the imaginative, flexible art of systems engineering is as necessary to mission success as is the rigorous, disciplined side of engineering. Engineering space systems involves many disciplines propulsion, loads, dynamics, and so forth that are based on the foundations of scientific principles and methodology and the application of the laws of physics. The term rocket scientist is an apt term, considering that the underlying chemical properties of propellants and the subatomic properties of materials must be understood to harness the powerful energy necessary to escape Earth's gravity in machines that can withstand the stresses and forces to which they are subjected, not to mention the harsh space environments in which they must work. This is a simplistic, yet illustrative, explanation of the scientific side of the engineer s challenge. Bringing together these individual parts into a solid system goes beyond the science of engineering to employ the art of systems engineering. Systems engineers are known for their ability to integrate various solutions to meet or exceed challenging requirements. As the old adage goes, measure twice and cut once. The act of measuring is balancing rigid, inflexible requirements with creative compromises to attain the optimum solution to the challenge of space flight. Then, we cut out those answers that are too risky, expensive, dangerous, and so forth. The process of sharing stories about the little-discussed art of engineering, also known as the art of compromise, will equip the workforce to subjectively judge the best right answer from among the many presented, while objectively integrating the various piece parts into a unified whole.

Materials Challenges in Space Exploration

NASA Technical Reports Server (NTRS)

Bhat, Biliyar N.

2005-01-01

United States civil space program administered by National Aeronautics and Space Administration has a new strategic direction to explore the solar system. This new 'vision for space exploration' encompasses a broad range of human and robotic missions, including the Moon. Mars and destinations beyond. These missions require advanced systems and capabilities that will accelerate the development of many critical technologies, including advanced materials and structural concepts. Specifically, it is planned to develop high-performance materials for vehicle structures, propulsion systems, and space suits; structural concepts for modular assembly for space infrastructure: lightweight deployable and inflatable structures for large space systems and crew habitats; and highly integrated structural systems and advanced thermal management systems for reducing launch mass and volume. This paper will present several materials challenges in advanced space systems-high performance structural and thermal materials, space durable materials, radiation protection materials, and nano-structural materials. Finally, the paper will take a look at the possibility of utilizing materials in situ, i.e., processing materials on the surface of the Moon and Mars.

Analysis of Multilayered Printed Circuit Boards using Computed Tomography

DTIC Science & Technology

2014-05-01

complex PCBs that present a challenge for any testing or fault analysis. Set-to- work testing and fault analysis of any electronic circuit require...Electronic Warfare and Radar Division in December 2010. He is currently in Electro- Optic Countermeasures Group. Samuel works on embedded system design...and software optimisation of complex electro-optical systems, including the set to work and characterisation of these systems. He has a Bachelor of

Evaluating Moisture Control of Variable-Capacity Heat Pumps in Mechanically Ventilated, Low-Load Homes in Climate Zone 2A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Eric; Withers, Chuck; McIlvaine, Janet

Low-load homes can present a challenge when selecting appropriate space-conditioning equipment. Conventional, fixed-capacity heating and cooling equipment is often oversized for small homes, causing increased first costs and operating costs. This report evaluates the performance of variable-capacity comfort systems, with a focus on inverter-driven, variable-capacity systems, as well as proposed system enhancements.

A Systems Analysis and Design Case Study for a Business Modeling Learning Experience for a Capstone CIS/IS Systems Development Class

ERIC Educational Resources Information Center

Russell, Jack; Russell, Barbara

2015-01-01

The goal is to provide a robust and challenging problem statement for a capstone, advanced systems analysis and design course for CIS/MIS/CS majors. In addition to the problem narrative, a representative solution for much of the business modeling deliverables is presented using the UML paradigm. A structured analysis deliverable will be the topic…

Changes in Psychological Distress among East German Adolescents Facing German Unification: The Role of Commitment to the Old System and of Self-Efficacy Beliefs

ERIC Educational Resources Information Center

Pinquart, Martin; Silbereisen, Rainer K.; Juang, Linda P.

2004-01-01

Abrupt social change, such as the breakdown of a political system of the former communist states, presents a major adaptive challenge to the individual. The authors analyzed whether commitment to the old political system and high self-efficacy beliefs measured before German unification would predict change in psychological distress in East German…

An ICT-Based Diabetes Management System Tested for Health Care Delivery in the African Context.

PubMed

Takenga, Claude; Berndt, Rolf-Dietrich; Musongya, Olivier; Kitero, Joël; Katoke, Remi; Molo, Kakule; Kazingufu, Basile; Meni, Malikwisha; Vikandy, Mambo; Takenga, Henri

2014-01-01

The demand for new healthcare services is growing rapidly. Improving accessibility of the African population to diabetes care seems to be a big challenge in most countries where the number of care centers and medical staff is reduced. Information and communication technologies (ICT) have great potential to address some of these challenges faced by several countries in providing accessible, cost-effective, and high-quality health care services. This paper presents the Mobil Diab system which is a telemedical approach proposed for the management of long-term diseases. The system applies modern mobile and web technologies which overcome geographical barriers, and increase access to health care services. The idea of the system is to involve patients in the therapy process and motivate them for an active participation. For validation of the system in African context, a trial was conducted in the Democratic Republic of Congo. 40 Subjects with diabetes divided randomly into control and intervention groups were included in the test. Results show that Mobil Diab is suitable for African countries and presents a number of benefits for the population and public health care system. It improves clinical management and delivery of diabetes care services by enhancing access, quality, motivation, reassurance, efficiency, and cost-effectiveness.

An ICT-Based Diabetes Management System Tested for Health Care Delivery in the African Context

PubMed Central

Takenga, Claude; Berndt, Rolf-Dietrich; Musongya, Olivier; Kitero, Joël; Katoke, Remi; Molo, Kakule; Kazingufu, Basile; Meni, Malikwisha; Vikandy, Mambo; Takenga, Henri

2014-01-01

The demand for new healthcare services is growing rapidly. Improving accessibility of the African population to diabetes care seems to be a big challenge in most countries where the number of care centers and medical staff is reduced. Information and communication technologies (ICT) have great potential to address some of these challenges faced by several countries in providing accessible, cost-effective, and high-quality health care services. This paper presents the Mobil Diab system which is a telemedical approach proposed for the management of long-term diseases. The system applies modern mobile and web technologies which overcome geographical barriers, and increase access to health care services. The idea of the system is to involve patients in the therapy process and motivate them for an active participation. For validation of the system in African context, a trial was conducted in the Democratic Republic of Congo. 40 Subjects with diabetes divided randomly into control and intervention groups were included in the test. Results show that Mobil Diab is suitable for African countries and presents a number of benefits for the population and public health care system. It improves clinical management and delivery of diabetes care services by enhancing access, quality, motivation, reassurance, efficiency, and cost-effectiveness. PMID:25136358

Challenges to parenting in a new culture: Implications for child and family welfare.

PubMed

Lewig, Kerry; Arney, Fiona; Salveron, Mary

2010-08-01

Increasing numbers of families arriving through Australia's humanitarian settlement scheme are coming into contact with Australian child protection systems. A large number of these families come from African and Middle Eastern countries and have common experiences of trauma, dislocation, loss and many are victims of genocide, war, and torture. Pre-migration experiences together with the considerable challenges of settling into a new country can significantly affect family well-being and parenting practices. It is therefore important that child and family welfare service planners are well informed about how best to support refugee families using culturally competent family intervention and community development practices. This paper draws on the findings of a research project designed to examine why recently arrived families from refugee backgrounds are presenting in the South Australian child protection system and to identify culturally appropriate strategies for intervention. The paper presents findings from the project that relate to (1) refugee parents', community members' and child protection practitioners' perspectives on the challenges to being a refugee parent in Australia and (2) strategies and resources relevant to prevention and early intervention in refugee families before statutory child protection intervention becomes necessary. Copyright (c)2009 Elsevier Ltd. All rights reserved.

The role of advanced sensing in smart cities.

PubMed

Hancke, Gerhard P; Silva, Bruno de Carvalho E; Hancke, Gerhard P

2012-12-27

In a world where resources are scarce and urban areas consume the vast majority of these resources, it is vital to make cities greener and more sustainable. Advanced systems to improve and automate processes within a city will play a leading role in smart cities. From smart design of buildings, which capture rain water for later use, to intelligent control systems, which can monitor infrastructures autonomously, the possible improvements enabled by sensing technologies are immense. Ubiquitous sensing poses numerous challenges, which are of a technological or social nature. This paper presents an overview of the state of the art with regards to sensing in smart cities. Topics include sensing applications in smart cities, sensing platforms and technical challenges associated with these technologies. In an effort to provide a holistic view of how sensing technologies play a role in smart cities, a range of applications and technical challenges associated with these applications are discussed. As some of these applications and technologies belong to different disciplines, the material presented in this paper attempts to bridge these to provide a broad overview, which can be of help to researchers and developers in understanding how advanced sensing can play a role in smart cities.

The Role of Advanced Sensing in Smart Cities

PubMed Central

Hancke, Gerhard P.; de Carvalho e Silva, Bruno; Hancke, Gerhard P.

2013-01-01

In a world where resources are scarce and urban areas consume the vast majority of these resources, it is vital to make cities greener and more sustainable. Advanced systems to improve and automate processes within a city will play a leading role in smart cities. From smart design of buildings, which capture rain water for later use, to intelligent control systems, which can monitor infrastructures autonomously, the possible improvements enabled by sensing technologies are immense. Ubiquitous sensing poses numerous challenges, which are of a technological or social nature. This paper presents an overview of the state of the art with regards to sensing in smart cities. Topics include sensing applications in smart cities, sensing platforms and technical challenges associated with these technologies. In an effort to provide a holistic view of how sensing technologies play a role in smart cities, a range of applications and technical challenges associated with these applications are discussed. As some of these applications and technologies belong to different disciplines, the material presented in this paper attempts to bridge these to provide a broad overview, which can be of help to researchers and developers in understanding how advanced sensing can play a role in smart cities. PMID:23271603

A service platform architecture design towards a light integration of heterogeneous systems in the wellbeing domain.

PubMed

Yang, Yaojin; Ahtinen, Aino; Lahteenmaki, Jaakko; Nyman, Petri; Paajanen, Henrik; Peltoniemi, Teijo; Quiroz, Carlos

2007-01-01

System integration is one of the major challenges for building wellbeing or healthcare related information systems. In this paper, we are going to share our experiences on how to design a service platform called Nuadu service platform, for providing integrated services in occupational health promotion and health risk management through two heterogeneous systems. Our design aims for a light integration covering the layers, from data through service up to presentation, while maintaining the integrity of the underlying systems.

Verification and Validation Challenges for Adaptive Flight Control of Complex Autonomous Systems

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.

2018-01-01

Autonomy of aerospace systems requires the ability for flight control systems to be able to adapt to complex uncertain dynamic environment. In spite of the five decades of research in adaptive control, the fact still remains that currently no adaptive control system has ever been deployed on any safety-critical or human-rated production systems such as passenger transport aircraft. The problem lies in the difficulty with the certification of adaptive control systems since existing certification methods cannot readily be used for nonlinear adaptive control systems. Research to address the notion of metrics for adaptive control began to appear in the recent years. These metrics, if accepted, could pave a path towards certification that would potentially lead to the adoption of adaptive control as a future control technology for safety-critical and human-rated production systems. Development of certifiable adaptive control systems represents a major challenge to overcome. Adaptive control systems with learning algorithms will never become part of the future unless it can be proven that they are highly safe and reliable. Rigorous methods for adaptive control software verification and validation must therefore be developed to ensure that adaptive control system software failures will not occur, to verify that the adaptive control system functions as required, to eliminate unintended functionality, and to demonstrate that certification requirements imposed by regulatory bodies such as the Federal Aviation Administration (FAA) can be satisfied. This presentation will discuss some of the technical issues with adaptive flight control and related V&V challenges.

Meeting the challenges of case management with remote patient monitoring technology.

PubMed

Cherry, J C; Colliflower, S J; Tsiperfal, A

2000-01-01

The article presents an overview of some of the current trends in health care and the challenges faced by nurse case managers who are providing disease management services. It discusses some of the emerging technologies available today for innovative case management. In particular, this article describes a program run by a healthcare system in Sacramento, California that uses an Internet-based technology to enhance their nurse case management model. The article demonstrates how the Health Hero platform enables interactive communication between nurse case managers and their patients, thereby meeting some of the challenges the nurse case managers are faced with in the modern disease-management world.

Investigation into the efficacy of generating synthetic pathological oscillations for domain adaptation

NASA Astrophysics Data System (ADS)

Lewis, Rory; Ellenberger, James; Williams, Colton; White, Andrew M.

2013-11-01

In the ongoing investigation of integrating Knowledge Discovery in Databases (KDD) into neuroscience, we present a paper that facilitates overcoming the two challenges preventing this integration. Pathological oscillations found in the human brain are difficult to evaluate because 1) there is often no time to learn and train off of the same distribution in the fatally sick, and 2) sinusoidal signals found in the human brain are complex and transient in nature requiring large data sets to work with which are costly and often very expensive or impossible to acquire. Overcoming these challenges in today's neuro-intensive-care unit (ICU) requires insurmountable resources. For these reasons, optimizing KDD for pathological oscillations so machine learning systems can predict neuropathological states would be of immense value. Domain adaptation, which allows a way of predicting on a separate set of data than the training data, can theoretically overcome the first challenge. However, the challenge of acquiring large data sets that show whether domain adaptation is a good candidate to test in a live neuro ICU remains a challenge. To solve this conundrum, we present a methodology for generating synthesized neuropathological oscillations for domain adaptation.

WE-EF-BRD-01: Past, Present and Future: MRI-Guided Radiotherapy From 2005 to 2025

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lagendijk, J.

MRI-guided treatment is a growing area of medicine, particularly in radiotherapy and surgery. The exquisite soft tissue anatomic contrast offered by MRI, along with functional imaging, makes the use of MRI during therapeutic procedures very attractive. Challenging the utility of MRI in the therapy room are many issues including the physics of MRI and the impact on the environment and therapeutic instruments, the impact of the room and instruments on the MRI; safety, space, design and cost. In this session, the applications and challenges of MRI-guided treatment will be described. The session format is: Past, present and future: MRI-guided radiotherapymore » from 2005 to 2025: Jan Lagendijk Battling Maxwell’s equations: Physics challenges and solutions for hybrid MRI systems: Paul Keall I want it now!: Advances in MRI acquisition, reconstruction and the use of priors to enable fast anatomic and physiologic imaging to inform guidance and adaptation decisions: Yanle Hu MR in the OR: The growth and applications of MRI for interventional radiology and surgery: Rebecca Fahrig Learning Objectives: To understand the history and trajectory of MRI-guided radiotherapy To understand the challenges of integrating MR imaging systems with linear accelerators To understand the latest in fast MRI methods to enable the visualisation of anatomy and physiology on radiotherapy treatment timescales To understand the growing role and challenges of MRI for image-guided surgical procedures My disclosures are publicly available and updated at: http://sydney.edu.au/medicine/radiation-physics/about-us/disclosures.php.« less