Estrogen receptor expert system overview and examples

EPA Science Inventory

The estrogen receptor expert system (ERES) is a rule-based system developed to prioritize chemicals based upon their potential for binding to the ER. The ERES was initially developed to predict ER affinity of chemicals from two specific EPA chemical inventories, antimicrobial pe...

How the provenance of electronic health record data matters for research: a case example using system mapping.

PubMed

Johnson, Karin E; Kamineni, Aruna; Fuller, Sharon; Olmstead, Danielle; Wernli, Karen J

2014-01-01

The use of electronic health records (EHRs) for research is proceeding rapidly, driven by computational power, analytical techniques, and policy. However, EHR-based research is limited by the complexity of EHR data and a lack of understanding about data provenance, meaning the context under which the data were collected. This paper presents system flow mapping as a method to help researchers more fully understand the provenance of their EHR data as it relates to local workflow. We provide two specific examples of how this method can improve data identification, documentation, and processing. EHRs store clinical and administrative data, often in unstructured fields. Each clinical system has a unique and dynamic workflow, as well as an EHR customized for local use. The EHR customization may be influenced by a broader context such as documentation required for billing. We present a case study with two examples of using system flow mapping to characterize EHR data for a local colorectal cancer screening process. System flow mapping demonstrated that information entered into the EHR during clinical practice required interpretation and transformation before it could be accurately applied to research. We illustrate how system flow mapping shaped our knowledge of the quality and completeness of data in two examples: (1) determining colonoscopy indication as recorded in the EHR, and (2) discovering a specific EHR form that captured family history. Researchers who do not consider data provenance risk compiling data that are systematically incomplete or incorrect. For example, researchers who are not familiar with the clinical workflow under which data were entered might miss or misunderstand patient information or procedure and diagnostic codes. Data provenance is a fundamental characteristic of research data from EHRs. Given the diversity of EHR platforms and system workflows, researchers need tools for evaluating and reporting data availability, quality, and transformations. Our case study illustrates how system mapping can inform researchers about the provenance of their data as it pertains to local workflows.

Guide on Data Models in the Selection and Use of Database Management Systems. Final Report.

ERIC Educational Resources Information Center

Gallagher, Leonard J.; Draper, Jesse M.

A tutorial introduction to data models in general is provided, with particular emphasis on the relational and network models defined by the two proposed ANSI (American National Standards Institute) database language standards. Examples based on the network and relational models include specific syntax and semantics, while examples from the other…

An illustrative overview of semi-quantitative MRI scoring of knee osteoarthritis: lessons learned from longitudinal observational studies.

PubMed

Roemer, F W; Hunter, D J; Crema, M D; Kwoh, C K; Ochoa-Albiztegui, E; Guermazi, A

2016-02-01

To introduce the most popular magnetic resonance imaging (MRI) osteoarthritis (OA) semi-quantitative (SQ) scoring systems to a broader audience with a focus on the most commonly applied scores, i.e., the MOAKS and WORMS system and illustrate similarities and differences. While the main structure and methodology of each scoring system are publicly available, the core of this overview will be an illustrative imaging atlas section including image examples from multiple OA studies applying MRI in regard to different features assessed, show specific examples of different grades and point out pitfalls and specifics of SQ assessment including artifacts, blinding to time point of acquisition and within-grade evaluation. Similarities and differences between different scoring systems are presented. Technical considerations are followed by a brief description of the most commonly utilized SQ scoring systems including their responsiveness and reliability. The second part is comprised of the atlas section presenting illustrative image examples. Evidence suggests that SQ assessment of OA by expert MRI readers is valid, reliable and responsive, which helps investigators to understand the natural history of this complex disease and to evaluate potential new drugs in OA clinical trials. Researchers have to be aware of the differences and specifics of the different systems to be able to engage in imaging assessment and interpretation of imaging-based data. SQ scoring has enabled us to explain associations of structural tissue damage with clinical manifestations of the disease and with morphological alterations thought to represent disease progression. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

An illustrative overview of semi-quantitative MRI scoring of knee osteoarthritis: Lessons learned from longitudinal observational studies

PubMed Central

Roemer, Frank W.; Hunter, David J.; Crema, Michel D.; Kwoh, C. Kent; Ochoa-Albiztegui, Elena; Guermazi, Ali

2015-01-01

Objective To introduce the most popular magnetic resonance imaging (MRI) osteoarthritis (OA) semi-quantitative (SQ) scoring systems to a broader audience with a focus on the most commonly applied scores, i.e. the MOAKS and WORMS system and illustrate similarities and differences. Design While the main structure and methodology of each scoring system are publicly available, the core of this overview will be an illustrative imaging atlas section including image examples from multiple osteoarthritis studies applying MRI in regard to different features assessed, show specific examples of different grades and point out pitfalls and specifics of SQ assessment including artifacts, blinding to time point of acquisition and within-grade evaluation. Results Similarities and differences between different scoring systems are presented. Technical considerations are followed by a brief description of the most commonly utilized SQ scoring systems including their responsiveness and reliability. The second part is comprised of the atlas section presenting illustrative image examples. Conclusions Evidence suggests that SQ assessment of OA by expert MRI readers is valid, reliable and responsive, which helps investigators to understand the natural history of this complex disease and to evaluate potential new drugs in OA clinical trials. Researchers have to be aware of the differences and specifics of the different systems to be able to engage in imaging assessment and interpretation of imaging-based data. SQ scoring has enabled us to explain associations of structural tissue damage with clinical manifestations of the disease and with morphological alterations thought to represent disease progression. PMID:26318656

Systems, methods and apparatus for modeling, specifying and deploying policies in autonomous and autonomic systems using agent-oriented software engineering

NASA Technical Reports Server (NTRS)

Sterritt, Roy (Inventor); Hinchey, Michael G. (Inventor); Penn, Joaquin (Inventor)

2011-01-01

Systems, methods and apparatus are provided through which in some embodiments, an agent-oriented specification modeled with MaCMAS, is analyzed, flaws in the agent-oriented specification modeled with MaCMAS are corrected, and an implementation is derived from the corrected agent-oriented specification. Described herein are systems, method and apparatus that produce fully (mathematically) tractable development of agent-oriented specification(s) modeled with methodology fragment for analyzing complex multiagent systems (MaCMAS) and policies for autonomic systems from requirements through to code generation. The systems, method and apparatus described herein are illustrated through an example showing how user formulated policies can be translated into a formal mode which can then be converted to code. The requirements-based programming systems, method and apparatus described herein may provide faster, higher quality development and maintenance of autonomic systems based on user formulation of policies.

Neuro-Linguistic Programming: Enhancing Teacher-Student Communications.

ERIC Educational Resources Information Center

Childers, John H., Jr.

1985-01-01

Defines Neurolinguistic Programming (NCP) and discusses specific dimensions of the model that have applications for classroom teaching. Describes five representational systems individuals use to process information and gives examples of effective and ineffective teacher-student communication for each system. (MCF)

Slicing AADL Specifications for Model Checking

NASA Technical Reports Server (NTRS)

Odenbrett, Maximilian; Nguyen, Viet Yen; Noll, Thomas

2010-01-01

To combat the state-space explosion problem in model checking larger systems, abstraction techniques can be employed. Here, methods that operate on the system specification before constructing its state space are preferable to those that try to minimize the resulting transition system as they generally reduce peak memory requirements. We sketch a slicing algorithm for system specifications written in (a variant of) the Architecture Analysis and Design Language (AADL). Given a specification and a property to be verified, it automatically removes those parts of the specification that are irrelevant for model checking the property, thus reducing the size of the corresponding transition system. The applicability and effectiveness of our approach is demonstrated by analyzing the state-space reduction for an example, employing a translator from AADL to Promela, the input language of the SPIN model checker.

Integrated Reconfigurable Intelligent Systems (IRIS) for Complex Naval Systems

DTIC Science & Technology

2011-02-23

INTRODUCTION 35 2.2 GENERAL MODEL SETUP 36 2.2.1 Co-Simulation Principles 36 2.2.2 Double pendulum : a simple example 38 2.2.3 Description of numerical... pendulum sample problem 45 2.3 DISCUSSION OF APPROACH WITH RESPECT TO PROPOSED SUBTASKS 49 2.4 RESULTS DISCUSSION AND FUTURE WORK 49 TASK 3...Kim and Praehofer 2000]. 2.2.2 Double pendulum : a simple example In order to be able to evaluate co-simulation principles, specifically an

Computer Software for Intelligent Systems.

ERIC Educational Resources Information Center

Lenat, Douglas B.

1984-01-01

Discusses the development and nature of computer software for intelligent systems, indicating that the key to intelligent problem-solving lies in reducing the random search for solutions. Formal reasoning methods, expert systems, and sources of power in problem-solving are among the areas considered. Specific examples of such software are…

SYSTID - A flexible tool for the analysis of communication systems.

NASA Technical Reports Server (NTRS)

Dawson, C. T.; Tranter, W. H.

1972-01-01

Description of the System Time Domain Simulation (SYSTID) computer-aided analysis program which is specifically structured for communication systems analysis. The SYSTID program is user oriented so that very little knowledge of computer techniques and very little programming ability are required for proper application. The program is designed so that the user can go from a system block diagram to an accurate simulation by simply programming a single English language statement for each block in the system. The mathematical and functional models available in the SYSTID library are presented. An example problem is given which illustrates the ease of modeling communication systems. Examples of the outputs available are presented, and proposed improvements are summarized.

Spaceflight Human System Standards

NASA Technical Reports Server (NTRS)

Holubec, Keith; Tillman, Barry; Connolly, Jan

2009-01-01

NASA created a new approach for human system integration and human performance standards. NASA created two documents a standard and a reference handbook. The standard is titled NASA Space Flight Human-System Standard (SFHSS) and consists of two-volumes: Volume 1- Crew Health This volume covers standards needed to support astronaut health (medical care, nutrition, sleep, exercise, etc.) Volume 2 Human Factors, Habitability and Environmental Health This volume covers the standards for system design that will maintain astronaut performance (ie., environmental factors, design of facilities, layout of workstations, and lighting requirements). It includes classic human factors requirements. The new standards document is written in terms so that it is applicable to a broad range of present and future NASA systems. The document states that all new programs prepare system-specific requirements that will meet the general standards. For example, the new standard does not specify a design should accommodate specific percentiles of a defined population. Rather, NASA-STD-3001, Volume 2 states that all programs shall prepare program-specific requirements that define the user population and their size ranges. The design shall then accommodate the full size range of those users. The companion reference handbook, Human Integration Design Handbook (HIDH), was developed to capture the design consideration information from NASA-STD-3000, and adds spaceflight lessons learned, gaps in knowledge, example solutions, and suggests research to further mature specific disciplines. The HIDH serves two major purposes: HIDH is the reference document for writing human factors requirements for specific systems. HIDH contains design guidance information that helps insure that designers create systems which safely and effectively accommodate the capabilities and limitations of space flight crews.

Empirical Validation of a New Category System: One Example.

ERIC Educational Resources Information Center

Rosenshine, Barak; And Others

This study found that data from previous research can be used to validate a new observational category system and that subscripting of the original ten categories of the Flanders Interaction Analysis System is useful in identifying more specific behaviors which correlate with student achievement. The new category system was the Expanded…

Technical Assistance Model for Long-Term Systems Change: Three State Examples

ERIC Educational Resources Information Center

Kasprzak, Christina; Hurth, Joicey; Lucas, Anne; Marshall, Jacqueline; Terrell, Adriane; Jones, Elizabeth

2010-01-01

The National Early Childhood Technical Assistance Center (NECTAC) Technical Assistance (TA) Model for Long-Term Systems Change (LTSC) is grounded in conceptual frameworks in the literature on systems change and systems thinking. The NECTAC conceptual framework uses a logic model approach to change developed specifically for states' infant and…

Causal tapestries for psychology and physics.

PubMed

Sulis, William H

2012-04-01

Archetypal dynamics is a formal approach to the modeling of information flow in complex systems used to study emergence. It is grounded in the Fundamental Triad of realisation (system), interpretation (archetype) and representation (formal model). Tapestries play a fundamental role in the framework of archetypal dynamics as a formal representational system. They represent information flow by means of multi layered, recursive, interlinked graphical structures that express both geometry (form or sign) and logic (semantics). This paper presents a detailed mathematical description of a specific tapestry model, the causal tapestry, selected for use in describing behaving systems such as appear in psychology and physics from the standpoint of Process Theory. Causal tapestries express an explicit Lorentz invariant transient now generated by means of a reality game. Observables are represented by tapestry informons while subjective or hidden components (for example intellectual and emotional processes) are incorporated into the reality game that determines the tapestry dynamics. As a specific example, we formulate a random graphical dynamical system using causal tapestries.

High performance VLSI telemetry data systems

NASA Technical Reports Server (NTRS)

Chesney, J.; Speciale, N.; Horner, W.; Sabia, S.

1990-01-01

NASA's deployment of major space complexes such as Space Station Freedom (SSF) and the Earth Observing System (EOS) will demand increased functionality and performance from ground based telemetry acquisition systems well above current system capabilities. Adaptation of space telemetry data transport and processing standards such as those specified by the Consultative Committee for Space Data Systems (CCSDS) standards and those required for commercial ground distribution of telemetry data, will drive these functional and performance requirements. In addition, budget limitations will force the requirement for higher modularity, flexibility, and interchangeability at lower cost in new ground telemetry data system elements. At NASA's Goddard Space Flight Center (GSFC), the design and development of generic ground telemetry data system elements, over the last five years, has resulted in significant solutions to these problems. This solution, referred to as the functional components approach includes both hardware and software components ready for end user application. The hardware functional components consist of modern data flow architectures utilizing Application Specific Integrated Circuits (ASIC's) developed specifically to support NASA's telemetry data systems needs and designed to meet a range of data rate requirements up to 300 Mbps. Real-time operating system software components support both embedded local software intelligence, and overall system control, status, processing, and interface requirements. These components, hardware and software, form the superstructure upon which project specific elements are added to complete a telemetry ground data system installation. This paper describes the functional components approach, some specific component examples, and a project example of the evolution from VLSI component, to basic board level functional component, to integrated telemetry data system.

Engineering and commercialization of human-device interfaces, from bone to brain.

PubMed

Knothe Tate, Melissa L; Detamore, Michael; Capadona, Jeffrey R; Woolley, Andrew; Knothe, Ulf

2016-07-01

Cutting edge developments in engineering of tissues, implants and devices allow for guidance and control of specific physiological structure-function relationships. Yet the engineering of functionally appropriate human-device interfaces represents an intractable challenge in the field. This leading opinion review outlines a set of current approaches as well as hurdles to design of interfaces that modulate transfer of information, i.a. forces, electrical potentials, chemical gradients and haptotactic paths, between endogenous and engineered body parts or tissues. The compendium is designed to bridge across currently separated disciplines by highlighting specific commonalities between seemingly disparate systems, e.g. musculoskeletal and nervous systems. We focus on specific examples from our own laboratories, demonstrating that the seemingly disparate musculoskeletal and nervous systems share common paradigms which can be harnessed to inspire innovative interface design solutions. Functional barrier interfaces that control molecular and biophysical traffic between tissue compartments of joints are addressed in an example of the knee. Furthermore, we describe the engineering of gradients for interfaces between endogenous and engineered tissues as well as between electrodes that physically and electrochemically couple the nervous and musculoskeletal systems. Finally, to promote translation of newly developed technologies into products, protocols, and treatments that benefit the patients who need them most, regulatory and technical challenges and opportunities are addressed on hand from an example of an implant cum delivery device that can be used to heal soft and hard tissues, from brain to bone. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

28 CFR Appendix to Part 20 - Commentary on Selected Sections of the Regulations on Criminal History Record Information Systems

Code of Federal Regulations, 2014 CFR

2014-07-01

..., nor any recipient of assistance under the provisions of this title shall use or reveal any research or... would include, for example, the Office of Investigation of the Food and Drug Administration, which has.... The specific dispositions listed in this subsection are examples only and are not to be construed as...

28 CFR Appendix to Part 20 - Commentary on Selected Sections of the Regulations on Criminal History Record Information Systems

Code of Federal Regulations, 2010 CFR

2010-07-01

..., nor any recipient of assistance under the provisions of this title shall use or reveal any research or... would include, for example, the Office of Investigation of the Food and Drug Administration, which has.... The specific dispositions listed in this subsection are examples only and are not to be construed as...

28 CFR Appendix to Part 20 - Commentary on Selected Sections of the Regulations on Criminal History Record Information Systems

Code of Federal Regulations, 2013 CFR

2013-07-01

..., nor any recipient of assistance under the provisions of this title shall use or reveal any research or... would include, for example, the Office of Investigation of the Food and Drug Administration, which has.... The specific dispositions listed in this subsection are examples only and are not to be construed as...

28 CFR Appendix to Part 20 - Commentary on Selected Sections of the Regulations on Criminal History Record Information Systems

Code of Federal Regulations, 2012 CFR

2012-07-01

..., nor any recipient of assistance under the provisions of this title shall use or reveal any research or... would include, for example, the Office of Investigation of the Food and Drug Administration, which has.... The specific dispositions listed in this subsection are examples only and are not to be construed as...

28 CFR Appendix to Part 20 - Commentary on Selected Sections of the Regulations on Criminal History Record Information Systems

Code of Federal Regulations, 2011 CFR

2011-07-01

..., nor any recipient of assistance under the provisions of this title shall use or reveal any research or... would include, for example, the Office of Investigation of the Food and Drug Administration, which has.... The specific dispositions listed in this subsection are examples only and are not to be construed as...

A comparative analysis of user preference-based and existing knowledge management systems attributes in the aerospace industry

NASA Astrophysics Data System (ADS)

Varghese, Nishad G.

Knowledge management (KM) exists in various forms throughout organizations. Process documentation, training courses, and experience sharing are examples of KM activities performed daily. The goal of KM systems (KMS) is to provide a tool set which serves to standardize the creation, sharing, and acquisition of business critical information. Existing literature provides numerous examples of targeted evaluations of KMS, focusing on specific system attributes. This research serves to bridge the targeted evaluations with an industry-specific, holistic approach. The user preferences of aerospace employees in engineering and engineering-related fields were compared to profiles of existing aerospace KMS based on three attribute categories: technical features, system administration, and user experience. The results indicated there is a statistically significant difference between aerospace user preferences and existing profiles in the user experience attribute category, but no statistically significant difference in the technical features and system administration attribute categories. Additional analysis indicated in-house developed systems exhibit higher technical features and user experience ratings than commercial-off-the-self (COTS) systems.

Storing files in a parallel computing system based on user or application specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faibish, Sorin; Bent, John M.; Nick, Jeffrey M.

2016-03-29

Techniques are provided for storing files in a parallel computing system based on a user-specification. A plurality of files generated by a distributed application in a parallel computing system are stored by obtaining a specification from the distributed application indicating how the plurality of files should be stored; and storing one or more of the plurality of files in one or more storage nodes of a multi-tier storage system based on the specification. The plurality of files comprise a plurality of complete files and/or a plurality of sub-files. The specification can optionally be processed by a daemon executing on onemore » or more nodes in a multi-tier storage system. The specification indicates how the plurality of files should be stored, for example, identifying one or more storage nodes where the plurality of files should be stored.« less

48 CFR 9.507-2 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contract clause. 9.507-2 Section 9.507-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING..., for example, when the first production contract using the contractor's specifications or work...

48 CFR 9.507-2 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract clause. 9.507-2 Section 9.507-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING..., for example, when the first production contract using the contractor's specifications or work...

48 CFR 9.507-2 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contract clause. 9.507-2 Section 9.507-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING..., for example, when the first production contract using the contractor's specifications or work...

48 CFR 9.507-2 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contract clause. 9.507-2 Section 9.507-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING..., for example, when the first production contract using the contractor's specifications or work...

Integrating Science and Engineering to Implement Evidence-Based Practices in Health Care Settings.

PubMed

Wu, Shinyi; Duan, Naihua; Wisdom, Jennifer P; Kravitz, Richard L; Owen, Richard R; Sullivan, J Greer; Wu, Albert W; Di Capua, Paul; Hoagwood, Kimberly Eaton

2015-09-01

Integrating two distinct and complementary paradigms, science and engineering, may produce more effective outcomes for the implementation of evidence-based practices in health care settings. Science formalizes and tests innovations, whereas engineering customizes and optimizes how the innovation is applied tailoring to accommodate local conditions. Together they may accelerate the creation of an evidence-based healthcare system that works effectively in specific health care settings. We give examples of applying engineering methods for better quality, more efficient, and safer implementation of clinical practices, medical devices, and health services systems. A specific example was applying systems engineering design that orchestrated people, process, data, decision-making, and communication through a technology application to implement evidence-based depression care among low-income patients with diabetes. We recommend that leading journals recognize the fundamental role of engineering in implementation research, to improve understanding of design elements that create a better fit between program elements and local context.

The Essen Learning Model--A Step towards a Representation of Learning Objectives.

ERIC Educational Resources Information Center

Bick, Markus; Pawlowski, Jan M.; Veith, Patrick

The importance of the Extensible Markup Language (XML) technology family in the field of Computer Assisted Learning (CAL) can not be denied. The Instructional Management Systems Project (IMS), for example, provides a learning resource XML binding specification. Considering this specification and other implementations using XML to represent…

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation

DOEpatents

Schaff, Ulrich Y.; Koh, Chung-Yan; Sommer, Gregory J.

2016-04-05

Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.

Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation

DOEpatents

Schaff, Ulrich Y; Koh, Chung-Yan; Sommer, Gregory J

2015-02-24

Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.

Low-Cost Learning Systems: The General Concept and Some Specific Examples.

ERIC Educational Resources Information Center

Nichols, Daryl G.

1982-01-01

Discusses Low Cost Learning (LCL), an instructional system that maximizes available resources while minimizing cost per pupil, and its use in primary education in Southeast Asia. Short descriptions of LCL programs in the Philippines, Indonesia, Thailand, and Liberia are provided. (JJD)

32 CFR Appendix F to Part 505 - Example of a System of Records Notice

Code of Federal Regulations, 2011 CFR

2011-07-01

... series number related to the subject matter, and the final letter group shows the system manager's... use office symbols. (e) Categories of Individuals: Describe the individuals covered by the system. Use non-technical, specific categories of individuals about whom the Department of Army keeps records. Do...

32 CFR Appendix F to Part 505 - Example of a System of Records Notice

Code of Federal Regulations, 2013 CFR

2013-07-01

... series number related to the subject matter, and the final letter group shows the system manager's... use office symbols. (e) Categories of Individuals: Describe the individuals covered by the system. Use non-technical, specific categories of individuals about whom the Department of Army keeps records. Do...

Creating adaptive web recommendation system based on user behavior

NASA Astrophysics Data System (ADS)

Walek, Bogdan

2018-01-01

The paper proposes adaptive web recommendation system based on user behavior. The proposed system uses expert system to evaluating and recommending suitable items of content. Relevant items are subsequently evaluated and filtered based on history of visited items and user´s preferred categories of items. Main parts of the proposed system are presented and described. The proposed recommendation system is verified on specific example.

Method of improving system performance and survivability through changing function

NASA Technical Reports Server (NTRS)

Hinchey, Michael G. (Inventor); Vassev, Emil I. (Inventor)

2012-01-01

A biologically-inspired system and method is provided for self-adapting behavior of swarm-based exploration missions, whereby individual components, for example, spacecraft, in the system can sacrifice themselves for the greater good of the entire system. The swarm-based system can exhibit emergent self-adapting behavior. Each component can be configured to exhibit self-sacrifice behavior based on Autonomic System Specification Language (ASSL).

Composing Data and Process Descriptions in the Design of Software Systems.

DTIC Science & Technology

1988-05-01

accompanying ’data’ specification. So, for example, the bank account of Section 2.2.3 became ACC = open? d -- ACCIin(d) ACCA = payin? p --* ACCeosi(Ap) wdraw...w --* ACCtidraw(A,w) bal! balance(A) --+ ACCA I close -+ STOP where A has abstract type Account , with operators (that is, side-effect free functions...n accounts .................. 43 3.5 Non-deterministic merge ........ ........................... 45 4.1 Specification of a ticket machine system

Biomimicry in textiles: past, present and potential. An overview

PubMed Central

Eadie, Leslie; Ghosh, Tushar K.

2011-01-01

The natural world around us provides excellent examples of functional systems built with a handful of materials. Throughout the millennia, nature has evolved to adapt and develop highly sophisticated methods to solve problems. There are numerous examples of functional surfaces, fibrous structures, structural colours, self-healing, thermal insulation, etc., which offer important lessons for the textile products of the future. This paper provides a general overview of the potential of bioinspired textile structures by highlighting a few specific examples of pertinent, inherently sustainable biological systems. Biomimetic research is a rapidly growing field and its true potential in the development of new and sustainable textiles can only be realized through interdisciplinary research rooted in a holistic understanding of nature. PMID:21325320

Biomimicry in textiles: past, present and potential. An overview.

PubMed

Eadie, Leslie; Ghosh, Tushar K

2011-06-06

The natural world around us provides excellent examples of functional systems built with a handful of materials. Throughout the millennia, nature has evolved to adapt and develop highly sophisticated methods to solve problems. There are numerous examples of functional surfaces, fibrous structures, structural colours, self-healing, thermal insulation, etc., which offer important lessons for the textile products of the future. This paper provides a general overview of the potential of bioinspired textile structures by highlighting a few specific examples of pertinent, inherently sustainable biological systems. Biomimetic research is a rapidly growing field and its true potential in the development of new and sustainable textiles can only be realized through interdisciplinary research rooted in a holistic understanding of nature. © 2011 The Royal Society

Interdisciplinary and multilevel optimum design

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, Jaroslaw; Haftka, Raphael T.

1986-01-01

Interactions among engineering disciplines and subsystems in engineering system design are surveyed and specific instances of such interactions are described. Examination of the interactions that a traditional design process in which the numerical values of major design variables are decided consecutively is likely to lead to a suboptimal design. Supporting numerical examples are a glider and a space antenna. Under an alternative approach introduced, the design and its sensitivity data from the subsystems and disciplines are generated concurrently and then made available to the system designer enabling him to modify the system design so as to improve its performance. Examples of a framework structure and an airliner wing illustrate that approach.

Experience Using Formal Methods for Specifying a Multi-Agent System

NASA Technical Reports Server (NTRS)

Rouff, Christopher; Rash, James; Hinchey, Michael; Szczur, Martha R. (Technical Monitor)

2000-01-01

The process and results of using formal methods to specify the Lights Out Ground Operations System (LOGOS) is presented in this paper. LOGOS is a prototype multi-agent system developed to show the feasibility of providing autonomy to satellite ground operations functions at NASA Goddard Space Flight Center (GSFC). After the initial implementation of LOGOS the development team decided to use formal methods to check for race conditions, deadlocks and omissions. The specification exercise revealed several omissions as well as race conditions. After completing the specification, the team concluded that certain tools would have made the specification process easier. This paper gives a sample specification of two of the agents in the LOGOS system and examples of omissions and race conditions found. It concludes with describing an architecture of tools that would better support the future specification of agents and other concurrent systems.

Use of Microcomputer to Manage Assessment Data.

ERIC Educational Resources Information Center

Vance, Booney; Hayden, David

1982-01-01

Examples are provided of a computerized special education management system used to manage assessment data for exceptional students. The system is designed to provide a simple yet efficient method of tracking data from educational and psychological evaluations (specifically the Wechsler Intelligence Scale for Children--Revised scores). (CL)

A scalable, self-analyzing digital locking system for use on quantum optics experiments.

PubMed

Sparkes, B M; Chrzanowski, H M; Parrain, D P; Buchler, B C; Lam, P K; Symul, T

2011-07-01

Digital control of optics experiments has many advantages over analog control systems, specifically in terms of the scalability, cost, flexibility, and the integration of system information into one location. We present a digital control system, freely available for download online, specifically designed for quantum optics experiments that allows for automatic and sequential re-locking of optical components. We show how the inbuilt locking analysis tools, including a white-noise network analyzer, can be used to help optimize individual locks, and verify the long term stability of the digital system. Finally, we present an example of the benefits of digital locking for quantum optics by applying the code to a specific experiment used to characterize optical Schrödinger cat states.

Coupling HYDRUS-1D with ArcGIS to estimate pesticide accumulation and leaching risk on a regional basis.

PubMed

Anlauf, Ruediger; Schaefer, Jenny; Kajitvichyanukul, Puangrat

2018-07-01

HYDRUS-1D is a well-established reliable instrument to simulate water and pesticide transport in soils. It is, however, a point-specific model which is usually used for site-specific simulations. Aim of the investigation was the development of pesticide accumulation and leaching risk maps for regions combining HYDRUS-1D as a model for pesticide fate with regional data in a geographical information system (GIS). It was realized in form of a python tool in ArcGIS. Necessary high resolution local soil information, however, is very often not available. Therefore, worldwide interpolated 250-m-grid soil data (SoilGrids.org) were successfully incorporated to the system. The functionality of the system is shown by examples from Thailand, where example regions that differ in soil properties and climatic conditions were exposed in the model system to pesticides with different properties. A practical application of the system will be the identification of areas where measures to optimize pesticide use should be implemented with priority. Copyright © 2018 Elsevier Ltd. All rights reserved.

Qualification of the flight-critical AFTI/F-16 digital flight control system. [Advanced Fighter Technology Integration

NASA Technical Reports Server (NTRS)

Mackall, D. A.; Ishmael, S. D.; Regenie, V. A.

1983-01-01

Qualification considerations for assuring the safety of a life-critical digital flight control system include four major areas: systems interactions, verification, validation, and configuration control. The AFTI/F-16 design, development, and qualification illustrate these considerations. In this paper, qualification concepts, procedures, and methodologies are discussed and illustrated through specific examples.

An elementary tutorial on formal specification and verification using PVS

NASA Technical Reports Server (NTRS)

Butler, Ricky W.

1993-01-01

A tutorial on the development of a formal specification and its verification using the Prototype Verification System (PVS) is presented. The tutorial presents the formal specification and verification techniques by way of specific example - an airline reservation system. The airline reservation system is modeled as a simple state machine with two basic operations. These operations are shown to preserve a state invariant using the theorem proving capabilities of PVS. The technique of validating a specification via 'putative theorem proving' is also discussed and illustrated in detail. This paper is intended for the novice and assumes only some of the basic concepts of logic. A complete description of user inputs and the PVS output is provided and thus it can be effectively used while one is sitting at a computer terminal.

Job Aid Manuals for Phase II--DESIGN of the Instructional Systems Development Model.

ERIC Educational Resources Information Center

Schulz, Russel E.; Farrell, Jean R.

Designed to supplement the descriptive authoring flowcharts presented in a companion volume, this manual includes specific guidance, examples, and other information referred to in the flowcharts for the implementation of the second phase of the Instructional Systems Development Model (ISD). The introductory section includes definitions;…

Job Aid Manuals for Phase I--ANALYZE of the Instructional Systems Development Model.

ERIC Educational Resources Information Center

Schulz, Russel E.; Farrell, Jean R.

Designed to supplement the descriptive authoring flowcharts in a companion volume, this manual includes specific guidance, examples, and other information referred to in the flowcharts for the implementation of the first phase of the Instructional Systems Development Model (ISD). The introductory section includes definitions; descriptions of…

Job Aid Manuals for Phase III--DEVELOP of the Instructional Systems Development Model.

ERIC Educational Resources Information Center

Schulz, Russel E.; Farrell, Jean R.

Designed to supplement the descriptive authoring flowcharts presented in a companion volume, this manual includes specific guidance, examples, and other information referred to in the flowcharts for the implementation of the third phase of the Instructional Systems Development Model (ISD). The introductory section includes definitions;…

Integrated Instrumentation and Sensor Systems Enabling Condition-Based Maintenance of Aerospace Equipment

DTIC Science & Technology

2012-01-01

systems . For some specific sensor requirements in the domains considered here, for example, assessing system behavior and component state in gas turbine ...Cost Objectives. In general , the implication of the suitability and life cycle cost [LCC] driven objectives for integrated instrumentation/sensor system ...section should be considered. In general , the systems engineering approach provided clear benefits in defining user significant IISS system requirements and

EMC analysis of MOS-1

NASA Astrophysics Data System (ADS)

Ishizawa, Y.; Abe, K.; Shirako, G.; Takai, T.; Kato, H.

The electromagnetic compatibility (EMC) control method, system EMC analysis method, and system test method which have been applied to test the components of the MOS-1 satellite are described. The merits and demerits of the problem solving, specification, and system approaches to EMC control are summarized, and the data requirements of the SEMCAP (specification and electromagnetic compatibility analysis program) computer program for verifying the EMI safety margin of the components are sumamrized. Examples of EMC design are mentioned, and the EMC design process and selection method for EMC critical points are shown along with sample EMC test results.

Knowledge-intensive software design systems: Can too much knowledge be a burden?

NASA Technical Reports Server (NTRS)

Keller, Richard M.

1992-01-01

While acknowledging the considerable benefits of domain-specific, knowledge-intensive approaches to automated software engineering, it is prudent to carefully examine the costs of such approaches, as well. In adding domain knowledge to a system, a developer makes a commitment to understanding, representing, maintaining, and communicating that knowledge. This substantial overhead is not generally associated with domain-independent approaches. In this paper, I examine the downside of incorporating additional knowledge, and illustrate with examples based on our experience in building the SIGMA system. I also offer some guidelines for developers building domain-specific systems.

An Approach for Implementation of Project Management Information Systems

NASA Astrophysics Data System (ADS)

Běrziša, Solvita; Grabis, Jānis

Project management is governed by project management methodologies, standards, and other regulatory requirements. This chapter proposes an approach for implementing and configuring project management information systems according to requirements defined by these methodologies. The approach uses a project management specification framework to describe project management methodologies in a standardized manner. This specification is used to automatically configure the project management information system by applying appropriate transformation mechanisms. Development of the standardized framework is based on analysis of typical project management concepts and process and existing XML-based representations of project management. A demonstration example of project management information system's configuration is provided.

Knowledge-intensive software design systems: Can too much knowledge be a burden?

NASA Technical Reports Server (NTRS)

Keller, Richard M.

1992-01-01

While acknowledging the considerable benefits of domain-specific, knowledge-intensive approaches to automated software engineering, it is prudent to carefully examine the costs of such approaches, as well. In adding domain knowledge to a system, a developer makes a commitment to understanding, representing, maintaining, and communicating that knowledge. This substantial overhead is not generally associated with domain-independent approaches. In this paper, I examine the downside of incorporating additional knowledge, and illustrate with examples based on our experiences building the SIGMA system. I also offer some guidelines for developers building domain-specific systems.

Granular biodurable nanomaterials: No convincing evidence for systemic toxicity.

PubMed

Moreno-Horn, Marcus; Gebel, Thomas

2014-11-01

Nanomaterials are usually defined by primary particle diameters ranging from 1 to 100 nm. The scope of this review is an evaluation of experimental animal studies dealing with the systemic levels and putative systemic effects induced by nanoparticles which can be characterized as being granular biodurable particles without known specific toxicity (GBP). Relevant examples of such materials comprise nanosized titanium dioxide (TiO2) and carbon black. The question was raised whether GBP nanomaterials systemically accumulate and may possess a relevant systemic toxicity. With few exceptions, the 56 publications reviewed were not performed using established standard protocols, for example, OECD guidelines but used non-standard study designs. The studies including kinetic investigations indicated that GBP nanomaterials were absorbed and systemically distributed to rather low portions only. There was no valid indication that GPB nanomaterials possess novel toxicological hazard properties. In addition, no convincing evidence for a relevant specific systemic toxicity of GBP nanomaterials could be identified. The minority of the papers reviewed (15/56) investigated both nanosized and microsized GBP materials in parallel. A relevant different translocation of GBP nanomaterials in contrast to GBP micromaterials was not observed in these studies. There was no evidence that GPB nanomaterials possess toxicological properties other than their micromaterial counterparts.

Efflux systems in bacteria and their metabolic engineering applications.

PubMed

Jones, Christopher M; Hernández Lozada, Néstor J; Pfleger, Brian F

2015-11-01

The production of valuable chemicals from metabolically engineered microbes can be limited by excretion from the cell. Efflux is often overlooked as a bottleneck in metabolic pathways, despite its impact on alleviating feedback inhibition and product toxicity. In the past, it has been assumed that endogenous efflux pumps and membrane porins can accommodate product efflux rates; however, there are an increasing number of examples wherein overexpressing efflux systems is required to improve metabolite production. In this review, we highlight specific examples from the literature where metabolite export has been studied to identify unknown transporters, increase tolerance to metabolites, and improve the production capabilities of engineered bacteria. The review focuses on the export of a broad spectrum of valuable chemicals including amino acids, sugars, flavins, biofuels, and solvents. The combined set of examples supports the hypothesis that efflux systems can be identified and engineered to confer export capabilities on industrially relevant microbes.

Analyzing Tabular and State-Transition Requirements Specifications in PVS

NASA Technical Reports Server (NTRS)

Owre, Sam; Rushby, John; Shankar, Natarajan

1997-01-01

We describe PVS's capabilities for representing tabular specifications of the kind advocated by Parnas and others, and show how PVS's Type Correctness Conditions (TCCs) are used to ensure certain well-formedness properties. We then show how these and other capabilities of PVS can be used to represent the AND/OR tables of Leveson and the Decision Tables of Sherry, and we demonstrate how PVS's TCCs can expose and help isolate errors in the latter. We extend this approach to represent the mode transition tables of the Software Cost Reduction (SCR) method in an attractive manner. We show how PVS can check these tables for well-formedness, and how PVS's model checking capabilities can be used to verify invariants and reachability properties of SCR requirements specifications, and inclusion relations between the behaviors of different specifications. These examples demonstrate how several capabilities of the PVS language and verification system can be used in combination to provide customized support for specific methodologies for documenting and analyzing requirements. Because they use only the standard capabilities of PVS, users can adapt and extend these customizations to suit their own needs. Those developing dedicated tools for individual methodologies may find these constructions in PVS helpful for prototyping purposes, or as a useful adjunct to a dedicated tool when the capabilities of a full theorem prover are required. The examples also illustrate the power and utility of an integrated general-purpose system such as PVS. For example, there was no need to adapt or extend the PVS model checker to make it work with SCR specifications described using the PVS TABLE construct: the model checker is applicable to any transition relation, independently of the PVS language constructs used in its definition.

Cyber attack analysis on cyber-physical systems: Detectability, severity, and attenuation strategy

NASA Astrophysics Data System (ADS)

Kwon, Cheolhyeon

Security of Cyber-Physical Systems (CPS) against malicious cyber attacks is an important yet challenging problem. Since most cyber attacks happen in erratic ways, it is usually intractable to describe and diagnose them systematically. Motivated by such difficulties, this thesis presents a set of theories and algorithms for a cyber-secure architecture of the CPS within the control theoretic perspective. Here, instead of identifying a specific cyber attack model, we are focused on analyzing the system's response during cyber attacks. Firstly, we investigate the detectability of the cyber attacks from the system's behavior under cyber attacks. Specifically, we conduct a study on the vulnerabilities in the CPS's monitoring system against the stealthy cyber attack that is carefully designed to avoid being detected by its detection scheme. After classifying three kinds of cyber attacks according to the attacker's ability to compromise the system, we derive the necessary and sufficient conditions under which such stealthy cyber attacks can be designed to cause the unbounded estimation error while not being detected. Then, the analytical design method of the optimal stealthy cyber attack that maximizes the estimation error is developed. The proposed stealthy cyber attack analysis is demonstrated with illustrative examples on Air Traffic Control (ATC) system and Unmanned Aerial Vehicle (UAV) navigation system applications. Secondly, in an attempt to study the CPSs' vulnerabilities in more detail, we further discuss a methodology to identify potential cyber threats inherent in the given CPSs and quantify the attack severity accordingly. We then develop an analytical algorithm to test the behavior of the CPS under various cyber attack combinations. Compared to a numerical approach, the analytical algorithm enables the prediction of the most effective cyber attack combinations without computing the severity of all possible attack combinations, thereby greatly reducing the computational cost. The proposed algorithm is validated through a linearized longitudinal motion of a UAV example. Finally, we propose an attack attenuation strategy via the controller design for CPSs that are robust to various types of cyber attacks. While the previous studies have investigated a secure control by assuming a specific attack strategy, in this research we propose a hybrid robust control scheme that contains multiple sub-controllers, each matched to a specific type of cyber attacks. Then the system can be adapted to various cyber attacks (including those that are not assumed for sub-controller design) by switching its sub-controllers to achieve the best performance. Then, a method for designing a secure switching logic to counter all possible cyber attacks is proposed and it verifies mathematically the system's performance and stability as well. The performance of the proposed control scheme is demonstrated by an example with the hybrid H2 - H-infinity controller applied to a UAV example.

TargetMiner: microRNA target prediction with systematic identification of tissue-specific negative examples.

PubMed

Bandyopadhyay, Sanghamitra; Mitra, Ramkrishna

2009-10-15

Prediction of microRNA (miRNA) target mRNAs using machine learning approaches is an important area of research. However, most of the methods suffer from either high false positive or false negative rates. One reason for this is the marked deficiency of negative examples or miRNA non-target pairs. Systematic identification of non-target mRNAs is still not addressed properly, and therefore, current machine learning approaches are compelled to rely on artificially generated negative examples for training. In this article, we have identified approximately 300 tissue-specific negative examples using a novel approach that involves expression profiling of both miRNAs and mRNAs, miRNA-mRNA structural interactions and seed-site conservation. The newly generated negative examples are validated with pSILAC dataset, which elucidate the fact that the identified non-targets are indeed non-targets.These high-throughput tissue-specific negative examples and a set of experimentally verified positive examples are then used to build a system called TargetMiner, a support vector machine (SVM)-based classifier. In addition to assessing the prediction accuracy on cross-validation experiments, TargetMiner has been validated with a completely independent experimental test dataset. Our method outperforms 10 existing target prediction algorithms and provides a good balance between sensitivity and specificity that is not reflected in the existing methods. We achieve a significantly higher sensitivity and specificity of 69% and 67.8% based on a pool of 90 feature set and 76.5% and 66.1% using a set of 30 selected feature set on the completely independent test dataset. In order to establish the effectiveness of the systematically generated negative examples, the SVM is trained using a different set of negative data generated using the method in Yousef et al. A significantly higher false positive rate (70.6%) is observed when tested on the independent set, while all other factors are kept the same. Again, when an existing method (NBmiRTar) is executed with the our proposed negative data, we observe an improvement in its performance. These clearly establish the effectiveness of the proposed approach of selecting the negative examples systematically. TargetMiner is now available as an online tool at www.isical.ac.in/ approximately bioinfo_miu

Marrying Two Existing Software Packages into an Efficient Online Tutoring Tool

ERIC Educational Resources Information Center

Byrne, Timothy

2007-01-01

Many teachers today use Learning Management Systems (LMS), several of which are open-source. Specific examples are Claroline and Moodle. However, they are not specifically designed for language learning, and hence not entirely suitable. In this article, I will compare two uses of the Claroline LMS available at Louvain-la-Neuve within the framework…

Eyeballing oscillators for pulsed Doppler radar

NASA Astrophysics Data System (ADS)

Goldman, S.

1985-03-01

The visibility of small targets to a Doppler radar system in the presence of large targets is limited by phase noise. Such limitations occur when an airborne radar searches the ground for a mobile vehicle. Under these conditions, the performance of the Doppler radar depends greatly on the specifications of its phased-locked oscillator. Goldman (1984) has discussed the steps required to evaluate the noise resulting from a pulsed Doppler radar system. In the present investigation, these techniques are applied in reverse to determine system specifications for oscillator noise. A 95-GHz pulsed Doppler radar system is used as an example of specifying system phase noise.

Integrating Science and Engineering to Implement Evidence-Based Practices in Health Care Settings

PubMed Central

Wu, Shinyi; Duan, Naihua; Wisdom, Jennifer P.; Kravitz, Richard L.; Owen, Richard R.; Sullivan, Greer; Wu, Albert W.; Di Capua, Paul; Hoagwood, Kimberly Eaton

2015-01-01

Integrating two distinct and complementary paradigms, science and engineering, may produce more effective outcomes for the implementation of evidence-based practices in health care settings. Science formalizes and tests innovations, whereas engineering customizes and optimizes how the innovation is applied tailoring to accommodate local conditions. Together they may accelerate the creation of an evidence-based healthcare system that works effectively in specific health care settings. We give examples of applying engineering methods for better quality, more efficient, and safer implementation of clinical practices, medical devices, and health services systems. A specific example was applying systems engineering design that orchestrated people, process, data, decision-making, and communication through a technology application to implement evidence-based depression care among low-income patients with diabetes. We recommend that leading journals recognize the fundamental role of engineering in implementation research, to improve understanding of design elements that create a better fit between program elements and local context. PMID:25217100

Interdisciplinary and multilevel optimum design. [in aerospace structural engineering

NASA Technical Reports Server (NTRS)

Sobieszczanski-Sobieski, Jaroslaw; Haftka, Raphael T.

1987-01-01

Interactions among engineering disciplines and subsystems in engineering system design are surveyed and specific instances of such interactions are described. Examination of the interactions that a traditional design process in which the numerical values of major design variables are decided consecutively is likely to lead to a suboptimal design. Supporting numerical examples are a glider and a space antenna. Under an alternative approach introduced, the design and its sensitivity data from the subsystems and disciplines are generated concurrently and then made available to the system designer enabling him to modify the system design so as to improve its performance. Examples of a framework structure and an airliner wing illustrate that approach.

Accuracy of perturbative master equations.

PubMed

Fleming, C H; Cummings, N I

2011-03-01

We consider open quantum systems with dynamics described by master equations that have perturbative expansions in the system-environment interaction. We show that, contrary to intuition, full-time solutions of order-2n accuracy require an order-(2n+2) master equation. We give two examples of such inaccuracies in the solutions to an order-2n master equation: order-2n inaccuracies in the steady state of the system and order-2n positivity violations. We show how these arise in a specific example for which exact solutions are available. This result has a wide-ranging impact on the validity of coupling (or friction) sensitive results derived from second-order convolutionless, Nakajima-Zwanzig, Redfield, and Born-Markov master equations.

Automated benchmark generation based upon a specification language

NASA Technical Reports Server (NTRS)

Rajan, N.; Feteih, S. E.; Saito, J.

1984-01-01

The problem of validating and verifying digital flight control system (DFCS) software is addressed in this paper. A new specification language DIVERS is proposed, and is the keystone of the approach. This language consists of keywords where each keyword represents an element in the block diagram of a DFCS. DIVERS has a dictionary which contains all the keywords a DFCS designer might need. Translator programs convert the system specifications into an executable, high-level language program. The features of translators are discussed and are elucidated by examples. This language is used to describe a typical flight software module.

Calorimetry of a Bose–Einstein-condensed photon gas

PubMed Central

Damm, Tobias; Schmitt, Julian; Liang, Qi; Dung, David; Vewinger, Frank; Weitz, Martin; Klaers, Jan

2016-01-01

Phase transitions, as the condensation of a gas to a liquid, are often revealed by a discontinuous behaviour of thermodynamic quantities. For liquid helium, for example, a divergence of the specific heat signals the transition from the normal fluid to the superfluid state. Apart from liquid helium, determining the specific heat of a Bose gas has proven to be a challenging task, for example, for ultracold atomic Bose gases. Here we examine the thermodynamic behaviour of a trapped two-dimensional photon gas, a system that allows us to spectroscopically determine the specific heat and the entropy of a nearly ideal Bose gas from the classical high temperature to the Bose-condensed quantum regime. The critical behaviour at the phase transition is clearly revealed by a cusp singularity of the specific heat. Regarded as a test of quantum statistical mechanics, our results demonstrate a quantitative agreement with its predictions at the microscopic level. PMID:27090978

An iterative requirements specification procedure for decision support systems.

PubMed

Brookes, C H

1987-08-01

Requirements specification is a key element in a DSS development project because it not only determines what is to be done, it also drives the evolution process. A procedure for requirements elicitation is described that is based on the decomposition of the DSS design task into a number of functions, subfunctions, and operators. It is postulated that the procedure facilitates the building of a DSS that is complete and integrates MIS, modelling and expert system components. Some examples given are drawn from the health administration field.

Software for integrated manufacturing systems, part 2

NASA Technical Reports Server (NTRS)

Volz, R. A.; Naylor, A. W.

1987-01-01

Part 1 presented an overview of the unified approach to manufacturing software. The specific characteristics of the approach that allow it to realize the goals of reduced cost, increased reliability and increased flexibility are considered. Why the blending of a components view, distributed languages, generics and formal models is important, why each individual part of this approach is essential, and why each component will typically have each of these parts are examined. An example of a specification for a real material handling system is presented using the approach and compared with the standard interface specification given by the manufacturer. Use of the component in a distributed manufacturing system is then compared with use of the traditional specification with a more traditional approach to designing the system. An overview is also provided of the underlying mechanisms used for implementing distributed manufacturing systems using the unified software/hardware component approach.

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2013 CFR

2013-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2012 CFR

2012-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2014 CFR

2014-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2011 CFR

2011-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

Australia's Vocational Education & Training System Annual National Report 1996. Volume 1: National Overview.

ERIC Educational Resources Information Center

Australian National Training Authority, Brisbane.

This document outlines the major features and achievements of the Australian vocational education and training system in 1996 and provides some illustrative examples of specific initiatives undertaken by states, territories, and the Commonwealth. Among the major achievements detailed in the report are the following: (1) for students--35,000 more…

32 CFR Appendix B to Part 806b - Preparing a System Notice

Code of Federal Regulations, 2010 CFR

2010-07-01

... authorizes using the Social Security Number as a personal identifier. Include this authority whenever the Social Security Number is used to retrieve records. Purpose: Describe briefly and specifically what the... records in the system: Storage: State the medium in which the Air Force keeps the records; for example, in...

Benchmarking--Current Availability, Possible New National Alternatives, and Making a Contribution to the Discussion

ERIC Educational Resources Information Center

Atchison, Eric S.; Hosch, Braden J.

2015-01-01

This chapter synthesizes the national discussion on other solutions to the Integrated Postsecondary Education Data System (IPEDS), such as a national student record system, and complications. The authors will briefly examine the pros and cons of IPEDS while primarily focusing on national alternatives, as well providing specific examples for…

Microcomputers in Libraries.

ERIC Educational Resources Information Center

Ertel, Monica M.

1984-01-01

This discussion of current microcomputer technologies available to libraries focuses on software applications in four major classifications: communications (online database searching); word processing; administration; and database management systems. Specific examples of library applications are given and six references are cited. (EJS)

LINKING GPS DATA TO GIS DATABASES IN NATURALISTIC STUDIES: EXAMPLES FROM DRIVERS WITH OBSTRUCTIVE SLEEP APNEA

PubMed Central

Dawson, Jeffrey D.; Yu, Lixi; Sewell, Kelly; Skibbe, Adam; Aksan, Nazan S.; Tippin, Jon; Rizzo, Matthew

2015-01-01

Summary In naturalistic studies, it is vital to give appropriate context when analyzing driving behaviors. Such contextualization can help address the hypotheses that explore a) how drivers perform within specific types of environment (e.g., road types, speed limits, etc.), and b) how often drivers are exposed to such specific environments. In order to perform this contextualization in an automated fashion, we are using Global Positioning System (GPS) data obtained at 1 Hz and merging this with Geographic Information Systems (GIS) databases maintained by the Iowa Department of Transportation (DOT). In this paper, we demonstrate our methods of doing this based on data from 43 drivers with obstructive sleep apnea (OSA). We also use maps from GIS software to illustrate how information can be displayed at the individual drive or day level, and we provide examples of some of the challenges that still need to be addressed. PMID:26665183

Increasing productivity of the McAuto CAD/CAE system by user-specific applications programming

NASA Technical Reports Server (NTRS)

Plotrowski, S. M.; Vu, T. H.

1985-01-01

Significant improvements in the productivity of the McAuto Computer-Aided Design/Computer-Aided Engineering (CAD/CAE) system were achieved by applications programming using the system's own Graphics Interactive Programming language (GRIP) and the interface capabilities with the main computer on which the system resides. The GRIP programs for creating springs, bar charts, finite element model representations and aiding management planning are presented as examples.

Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

PubMed Central

Jena, Bipulendu; Dotti, Gianpietro

2010-01-01

Infusions of antigen-specific T cells have yielded therapeutic responses in patients with pathogens and tumors. To broaden the clinical application of adoptive immunotherapy against malignancies, investigators have developed robust systems for the genetic modification and characterization of T cells expressing introduced chimeric antigen receptors (CARs) to redirect specificity. Human trials are under way in patients with aggressive malignancies to test the hypothesis that manipulating the recipient and reprogramming T cells before adoptive transfer may improve their therapeutic effect. These examples of personalized medicine infuse T cells designed to meet patients' needs by redirecting their specificity to target molecular determinants on the underlying malignancy. The generation of clinical grade CAR+ T cells is an example of bench-to-bedside translational science that has been accomplished using investigator-initiated trials operating largely without industry support. The next-generation trials will deliver designer T cells with improved homing, CAR-mediated signaling, and replicative potential, as investigators move from the bedside to the bench and back again. PMID:20439624

Multiple Award, Multiple Order Contracts - The Future of Navy Surface Maintenance Procurement

DTIC Science & Technology

2015-06-01

example, in October 2004, Australia’s North West Shelf Shipping signed a long-term maintenance and upgrade contract for its fleet of liquefied natural ...fuel tank during shipyard corrosion control activities (e.g., grinding and/or sanding) and there was already a work item in the contract for crack...is not related to items in the original contract. An example of new work is adding fuel tank repair to a combat systems equipment-specific

Thermo-mechanical design aspects of mercury bombardment ion thrusters.

NASA Technical Reports Server (NTRS)

Schnelker, D. E.; Kami, S.

1972-01-01

The mechanical design criteria are presented as background considerations for solving problems associated with the thermomechanical design of mercury ion bombardment thrusters. Various analytical procedures are used to aid in the development of thruster subassemblies and components in the fields of heat transfer, vibration, and stress analysis. Examples of these techniques which provide computer solutions to predict and control stress levels encountered during launch and operation of thruster systems are discussed. Computer models of specific examples are presented.

Computer Bytes, Viruses and Vaccines.

ERIC Educational Resources Information Center

Palmore, Teddy B.

1989-01-01

Presents a history of computer viruses, explains various types of viruses and how they affect software or computer operating systems, and describes examples of specific viruses. Available vaccines are explained, and precautions for protecting programs and disks are given. (nine references) (LRW)

Near East/South Asia Report

DTIC Science & Technology

1985-04-05

the air defense system Amon, a system which the. Contraves company developed by means of the Skyguard system on the basia of specifications engineers...of the Contraves Company and the Arab Industrialization Authority exhibits, displayed a group of armored vehicles, military transport vehicles...the most up-to-date kind, constituting a fair in itself. Take the Contraves Company, for example, which exhibited the latest aerial defense material

Standardizing the atomic description, axis and centre of biological ion channels.

PubMed

Kaats, Adrian J; Galiana, Henrietta L; Nadeau, Jay L

2007-09-15

A general representation of the atomic co-ordinates of a biological ion channel is obtained from a definition of channel axis and centre. Through rotation and translation of the channel, its centre becomes the origin of the standard co-ordinate system, and the channel axis becomes the system's z-axis. A method for determining the channel axis and centre based on the concepts of mass centre and mass moment of inertia is presented. The method for determining the channel axis can be directly applied to channels that adhere to two specific conditions regarding their geometry and mass distribution. Specific examples are given for Gramicidin A (GA), and the mammalian potassium channel Kv 1.2. For channels that do not adhere to these conditions, minor modifications of these procedures can be applied in determining the channel axis. Specific examples are given for the outer membrane bacterial porin OmpF, and for the staphylococcal pore-forming toxin alpha-hemolysin (alpha HL). The definitions and procedures presented are made in an effort to establish a standard basis for performing, sharing, and comparing computations in a consistent manner.

Managing Risks and Beyond

DTIC Science & Technology

2010-04-01

immediate, a trigger should be defined  • Examples of triggers may include:        – Cost performance – Schedule performance R lt f t i– esu s o   managemen ...nput  nto  t e system  y e t er  t e a.   operator , or b.  technical user MITRE Al Florence 117 Example 6  • Initial specification: 3.3.2.1 The system...Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware

Evolution and coevolution of developmental programs

NASA Astrophysics Data System (ADS)

Jacob, Christian

1999-09-01

The developmental processes of single organisms, such as growth and structure formation, can be described by parallel rewrite systems in the form of Lindenmayer systems, which also allow one to generate geometrical structures in 3D space using turtle interpretation. We present examples of L-systems for growth programs of plant-like structures. Evolution-based programming techniques are applied to design L-systems by Genetic L-system Programming (GLP), demonstrating how developmental programs for plants, exhibiting specific morphogenetic properties can be interactively bred or automatically evolved. Finally, we demonstrate coevolutionary effects among plant populations consisting of different species, interacting with each other, competing for resources like sunlight and nutrients, and evolving successful reproduction strategies in their specific environments.

Validation of a SysML based design for wireless sensor networks

NASA Astrophysics Data System (ADS)

Berrachedi, Amel; Rahim, Messaoud; Ioualalen, Malika; Hammad, Ahmed

2017-07-01

When developing complex systems, the requirement for the verification of the systems' design is one of the main challenges. Wireless Sensor Networks (WSNs) are examples of such systems. We address the problem of how WSNs must be designed to fulfil the system requirements. Using the SysML Language, we propose a Model Based System Engineering (MBSE) specification and verification methodology for designing WSNs. This methodology uses SysML to describe the WSNs requirements, structure and behaviour. Then, it translates the SysML elements to an analytic model, specifically, to a Deterministic Stochastic Petri Net. The proposed approach allows to design WSNs and study their behaviors and their energy performances.

RT-Syn: A real-time software system generator

NASA Technical Reports Server (NTRS)

Setliff, Dorothy E.

1992-01-01

This paper presents research into providing highly reusable and maintainable components by using automatic software synthesis techniques. This proposal uses domain knowledge combined with automatic software synthesis techniques to engineer large-scale mission-critical real-time software. The hypothesis centers on a software synthesis architecture that specifically incorporates application-specific (in this case real-time) knowledge. This architecture synthesizes complex system software to meet a behavioral specification and external interaction design constraints. Some examples of these external constraints are communication protocols, precisions, timing, and space limitations. The incorporation of application-specific knowledge facilitates the generation of mathematical software metrics which are used to narrow the design space, thereby making software synthesis tractable. Success has the potential to dramatically reduce mission-critical system life-cycle costs not only by reducing development time, but more importantly facilitating maintenance, modifications, and extensions of complex mission-critical software systems, which are currently dominating life cycle costs.

NED-IIS: An Intelligent Information System for Forest Ecosystem Management

Treesearch

W.D. Potter; S. Somasekar; R. Kommineni; H.M. Rauscher

1999-01-01

We view Intelligent Information System (IIS) as composed of a unified knowledge base, database, and model base. The model base includes decision support models, forecasting models, and cvsualization models for example. In addition, we feel that the model base should include domain specific porblems solving modules as well as decision support models. This, then,...

Using client feedback in psychotherapy from an interpersonal process perspective.

PubMed

Reese, Robert J; Slone, Norah C; Miserocchi, Kristin M

2013-09-01

The process of monitoring treatment outcome, also known as "client feedback," is increasingly becoming a recommended practice for psychotherapy. One concern, however, is how to integrate such a process into the work that psychotherapists typically do. Three clinical examples are presented, illustrating how a client feedback system can be used in conjunction with a specific theoretical framework, interpersonal process therapy (Teyber, 2006). The examples highlight that client feedback not only can be of minimal disruption to the psychotherapy process, but may also offer the potential to augment a clinician's approach to helping. Theoretical and research support are provided for each example. 2013 APA, all rights reserved

Combining Modeling and Monitoring to Produce a New Paradigm of an Integrated Approach to Providing Long-Term Control of Contaminants

NASA Astrophysics Data System (ADS)

Fogwell, T. W.

2009-12-01

Sir David King, Chief Science Advisor to the British government and Cambridge University Professor, stated in October 2005, "The scientific community is considerably more capable than it has been in the past to assist governments to avoid and reduce risk to their own populations. Prime ministers and presidents ignore the advice from the science community at the peril of their own populations." Some of these greater capabilities can be found in better monitoring techniques applied to better modeling methods. These modeling methods can be combined with the information derived from monitoring data in order to decrease the risk of population exposure to dangerous substances and to promote efficient control or cleanup of the contaminants. An introduction is presented of the types of problems that exist for long-term control of radionuclides at DOE sites. A breakdown of the distributions at specific sites is given, together with the associated difficulties. A paradigm for remediation showing the integration of monitoring with modeling is presented. It is based on a feedback system that allows for the monitoring to act as principal sensors in a control system. The resulting system can be optimized to improve performance. Optimizing monitoring automatically entails linking the monitoring with modeling. If monitoring designs were required to be more efficient, thus requiring optimization, then the monitoring automatically becomes linked to modeling. Records of decision could be written to accommodate revisions in monitoring as better modeling evolves. Currently the establishment of a very prescriptive monitoring program fails to have a mechanism for improving models and improving control of the contaminants. The technical pieces of the required paradigm are already available; they just need to be implemented and applied to solve the long-term control of the contaminants. An integration of the various parts of the system is presented. Each part is described, and examples are given. References are given to other projects which bring together similar elements in systems for the control of contaminants. Trends are given for the development of the technical features of a robust system. Examples of monitoring methods for specific sites are given. The examples are used to illustrate how such a system would work. Examples of technology needs are presented. Finally, other examples of integrated modeling-monitoring approaches are presented.

A Logical Process Calculus

NASA Technical Reports Server (NTRS)

Cleaveland, Rance; Luettgen, Gerald; Bushnell, Dennis M. (Technical Monitor)

2002-01-01

This paper presents the Logical Process Calculus (LPC), a formalism that supports heterogeneous system specifications containing both operational and declarative subspecifications. Syntactically, LPC extends Milner's Calculus of Communicating Systems with operators from the alternation-free linear-time mu-calculus (LT(mu)). Semantically, LPC is equipped with a behavioral preorder that generalizes Hennessy's and DeNicola's must-testing preorder as well as LT(mu's) satisfaction relation, while being compositional for all LPC operators. From a technical point of view, the new calculus is distinguished by the inclusion of: (1) both minimal and maximal fixed-point operators and (2) an unimple-mentability predicate on process terms, which tags inconsistent specifications. The utility of LPC is demonstrated by means of an example highlighting the benefits of heterogeneous system specification.

Integration and Interoperability: An Analysis to Identify the Attributes for System of Systems

DTIC Science & Technology

2008-09-01

divisions of the enterprise. Examples of the current I2 are: • a nightly feed of elearning information is captured through an automated and...standardized process throughout the enterprise and • the LMS has been integrated with SkillSoft, a third party elearning software system, (http...Command (JITC) is responsible to test all programs that utilize standard interfaces to specific global nets or systems. Many times programs that

Development of Genome Engineering Tools from Plant-Specific PPR Proteins Using Animal Cultured Cells.

PubMed

Kobayashi, Takehito; Yagi, Yusuke; Nakamura, Takahiro

2016-01-01

The pentatricopeptide repeat (PPR) motif is a sequence-specific RNA/DNA-binding module. Elucidation of the RNA/DNA recognition mechanism has enabled engineering of PPR motifs as new RNA/DNA manipulation tools in living cells, including for genome editing. However, the biochemical characteristics of PPR proteins remain unknown, mostly due to the instability and/or unfolding propensities of PPR proteins in heterologous expression systems such as bacteria and yeast. To overcome this issue, we constructed reporter systems using animal cultured cells. The cell-based system has highly attractive features for PPR engineering: robust eukaryotic gene expression; availability of various vectors, reagents, and antibodies; highly efficient DNA delivery ratio (>80 %); and rapid, high-throughput data production. In this chapter, we introduce an example of such reporter systems: a PPR-based sequence-specific translational activation system. The cell-based reporter system can be applied to characterize plant genes of interested and to PPR engineering.

Image Retrieval by Color Semantics with Incomplete Knowledge.

ERIC Educational Resources Information Center

Corridoni, Jacopo M.; Del Bimbo, Alberto; Vicario, Enrico

1998-01-01

Presents a system which supports image retrieval by high-level chromatic contents, the sensations that color accordances generate on the observer. Surveys Itten's theory of color semantics and discusses image description and query specification. Presents examples of visual querying. (AEF)

Task allocation in a distributed computing system

NASA Technical Reports Server (NTRS)

Seward, Walter D.

1987-01-01

A conceptual framework is examined for task allocation in distributed systems. Application and computing system parameters critical to task allocation decision processes are discussed. Task allocation techniques are addressed which focus on achieving a balance in the load distribution among the system's processors. Equalization of computing load among the processing elements is the goal. Examples of system performance are presented for specific applications. Both static and dynamic allocation of tasks are considered and system performance is evaluated using different task allocation methodologies.

Reactive system verification case study: Fault-tolerant transputer communication

NASA Technical Reports Server (NTRS)

Crane, D. Francis; Hamory, Philip J.

1993-01-01

A reactive program is one which engages in an ongoing interaction with its environment. A system which is controlled by an embedded reactive program is called a reactive system. Examples of reactive systems are aircraft flight management systems, bank automatic teller machine (ATM) networks, airline reservation systems, and computer operating systems. Reactive systems are often naturally modeled (for logical design purposes) as a composition of autonomous processes which progress concurrently and which communicate to share information and/or to coordinate activities. Formal (i.e., mathematical) frameworks for system verification are tools used to increase the users' confidence that a system design satisfies its specification. A framework for reactive system verification includes formal languages for system modeling and for behavior specification and decision procedures and/or proof-systems for verifying that the system model satisfies the system specifications. Using the Ostroff framework for reactive system verification, an approach to achieving fault-tolerant communication between transputers was shown to be effective. The key components of the design, the decoupler processes, may be viewed as discrete-event-controllers introduced to constrain system behavior such that system specifications are satisfied. The Ostroff framework was also effective. The expressiveness of the modeling language permitted construction of a faithful model of the transputer network. The relevant specifications were readily expressed in the specification language. The set of decision procedures provided was adequate to verify the specifications of interest. The need for improved support for system behavior visualization is emphasized.

Specifying real-time systems with interval logic

NASA Technical Reports Server (NTRS)

Rushby, John

1988-01-01

Pure temporal logic makes no reference to time. An interval temporal logic and an extension to that logic which includes real time constraints are described. The application of this logic by giving a specification for the well-known lift (elevator) example is demonstrated. It is shown how interval logic can be extended to include a notion of process. How the specification language and verification environment of EHDM could be enhanced to support this logic is described. A specification of the alternating bit protocol in this extended version of the specification language of EHDM is given.

Rapid architecture alternative modeling (RAAM): A framework for capability-based analysis of system of systems architectures

NASA Astrophysics Data System (ADS)

Iacobucci, Joseph V.

The research objective for this manuscript is to develop a Rapid Architecture Alternative Modeling (RAAM) methodology to enable traceable Pre-Milestone A decision making during the conceptual phase of design of a system of systems. Rather than following current trends that place an emphasis on adding more analysis which tends to increase the complexity of the decision making problem, RAAM improves on current methods by reducing both runtime and model creation complexity. RAAM draws upon principles from computer science, system architecting, and domain specific languages to enable the automatic generation and evaluation of architecture alternatives. For example, both mission dependent and mission independent metrics are considered. Mission dependent metrics are determined by the performance of systems accomplishing a task, such as Probability of Success. In contrast, mission independent metrics, such as acquisition cost, are solely determined and influenced by the other systems in the portfolio. RAAM also leverages advances in parallel computing to significantly reduce runtime by defining executable models that are readily amendable to parallelization. This allows the use of cloud computing infrastructures such as Amazon's Elastic Compute Cloud and the PASTEC cluster operated by the Georgia Institute of Technology Research Institute (GTRI). Also, the amount of data that can be generated when fully exploring the design space can quickly exceed the typical capacity of computational resources at the analyst's disposal. To counter this, specific algorithms and techniques are employed. Streaming algorithms and recursive architecture alternative evaluation algorithms are used that reduce computer memory requirements. Lastly, a domain specific language is created to provide a reduction in the computational time of executing the system of systems models. A domain specific language is a small, usually declarative language that offers expressive power focused on a particular problem domain by establishing an effective means to communicate the semantics from the RAAM framework. These techniques make it possible to include diverse multi-metric models within the RAAM framework in addition to system and operational level trades. A canonical example was used to explore the uses of the methodology. The canonical example contains all of the features of a full system of systems architecture analysis study but uses fewer tasks and systems. Using RAAM with the canonical example it was possible to consider both system and operational level trades in the same analysis. Once the methodology had been tested with the canonical example, a Suppression of Enemy Air Defenses (SEAD) capability model was developed. Due to the sensitive nature of analyses on that subject, notional data was developed. The notional data has similar trends and properties to realistic Suppression of Enemy Air Defenses data. RAAM was shown to be traceable and provided a mechanism for a unified treatment of a variety of metrics. The SEAD capability model demonstrated lower computer runtimes and reduced model creation complexity as compared to methods currently in use. To determine the usefulness of the implementation of the methodology on current computing hardware, RAAM was tested with system of system architecture studies of different sizes. This was necessary since system of systems may be called upon to accomplish thousands of tasks. It has been clearly demonstrated that RAAM is able to enumerate and evaluate the types of large, complex design spaces usually encountered in capability based design, oftentimes providing the ability to efficiently search the entire decision space. The core algorithms for generation and evaluation of alternatives scale linearly with expected problem sizes. The SEAD capability model outputs prompted the discovery a new issue, the data storage and manipulation requirements for an analysis. Two strategies were developed to counter large data sizes, the use of portfolio views and top 'n' analysis. This proved the usefulness of the RAAM framework and methodology during Pre-Milestone A capability based analysis. (Abstract shortened by UMI.).

An approach to built-in test for shipboard machinery systems

NASA Astrophysics Data System (ADS)

Hegner, H. R.

This paper presents an approach for incorporating built-in test (BIT) into shipboard machinery systems. BIT, as used herein, denotes both built-in test and on-line monitoring. Since sensors are a key element to a successful machinery monitoring system, an assessment of shipboard sensors is included in the paper. Specific design examples are also presented for a marine diesel engine, gas turbine engine, and air conditioning plant.

Specification and preliminary design of the CARTA system for satellite cartography

NASA Technical Reports Server (NTRS)

Machadoesilva, A. J. F. (Principal Investigator); Neto, G. C.; Serra, P. R. M.; Souza, R. C. M.; Mitsuo, Fernando Augusta, II

1984-01-01

Digital imagery acquired by satellite have inherent geometrical distortion due to sensor characteristics and to platform variations. In INPE a software system for geometric correction of LANDSAT MSS imagery is under development. Such connected imagery will be useful for map generation. Important examples are the generation of LANDSAT image-charts for the Amazon region and the possibility of integrating digital satellite imagery into a Geographic Information System.

Web-based, mobile-device friendly, self-report survey system incorporating avatars and gaming console techniques.

PubMed

Savel, Craig; Mierzwa, Stan; Gorbach, Pamina; Lally, Michelle; Zimet, Gregory; Meyer, Kristin; Souidi, Samir; Interventions, Aids

2014-01-01

We describe building an avatar-based self-report data collection tool to be used for a specific HIV prevention research project that is evaluating the feasibility and acceptability of this novel approach to collect self-reported data among youth. We discuss the gathering of requirements, the process of building a prototype of the envisioned system, and the lessons learned during the development of the solution. Specific knowledge is shared regarding technical experience with software development technologies and possible avenues for changes that could be considered if such a self-report survey system is used again. Examples of other gaming and avatar technology systems are included to provide further background.

Web-based, mobile-device friendly, self-report survey system incorporating avatars and gaming console techniques

PubMed Central

Savel, Craig; Mierzwa, Stan; Gorbach, Pamina; Lally, Michelle; Zimet, Gregory; Meyer, Kristin; Souidi, Samir; Interventions, AIDS

2014-01-01

We describe building an avatar-based self-report data collection tool to be used for a specific HIV prevention research project that is evaluating the feasibility and acceptability of this novel approach to collect self-reported data among youth. We discuss the gathering of requirements, the process of building a prototype of the envisioned system, and the lessons learned during the development of the solution. Specific knowledge is shared regarding technical experience with software development technologies and possible avenues for changes that could be considered if such a self-report survey system is used again. Examples of other gaming and avatar technology systems are included to provide further background. PMID:25422726

Simulation of interference between Earth stations and Earth-orbiting satellites

NASA Technical Reports Server (NTRS)

Bishop, D. F.

1994-01-01

It is often desirable to determine the potential for radio frequency interference between earth stations and orbiting spacecraft. This information can be used to select frequencies for radio systems to avoid interference or it can be used to determine if coordination between radio systems is necessary. A model is developed that will determine the statistics of interference between earth stations and elliptical orbiting spacecraft. The model uses orbital dynamics, detailed antenna patterns, and spectral characteristics to obtain accurate levels of interference at the victim receiver. The model is programmed into a computer simulation to obtain long-term statistics of interference. Two specific examples are shown to demonstrate the model. The first example is a simulation of interference from a fixed-satellite earth station to an orbiting scatterometer receiver. The second example is a simulation of interference from earth-exploration satellites to a deep-space earth station.

Uncertainty and probability in wildfire management decision support: An example from the United States [Chapter 4

Treesearch

Matthew Thompson; David Calkin; Joe H. Scott; Michael Hand

2017-01-01

Wildfire risk assessment is increasingly being adopted to support federal wildfire management decisions in the United States. Existing decision support systems, specifically the Wildland Fire Decision Support System (WFDSS), provide a rich set of probabilistic and risk‐based information to support the management of active wildfire incidents. WFDSS offers a wide range...

The Impact of Emerging MEMS-Based Microsystems on US Defense Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

STAPLE,BEVAN D.; JAKUBCZAK II,JEROME F.

2000-01-20

This paper examines the impact of inserting Micro-Electro-Mechanical Systems (MEMS) into US defense applications. As specific examples, the impacts of micro Inertial Measurement Units (IMUs), radio frequency MEMS (RF MEMS), and Micro-Opto-Electro-Mechanical Systems (MOEMS) to provide integrated intelligence, communication, and control to the defense infrastructure with increased affordability, functionality, and performance are highlighted.

Formal verification of AI software

NASA Technical Reports Server (NTRS)

Rushby, John; Whitehurst, R. Alan

1989-01-01

The application of formal verification techniques to Artificial Intelligence (AI) software, particularly expert systems, is investigated. Constraint satisfaction and model inversion are identified as two formal specification paradigms for different classes of expert systems. A formal definition of consistency is developed, and the notion of approximate semantics is introduced. Examples are given of how these ideas can be applied in both declarative and imperative forms.

Flexibility and Performance of Parallel File Systems

NASA Technical Reports Server (NTRS)

Kotz, David; Nieuwejaar, Nils

1996-01-01

As we gain experience with parallel file systems, it becomes increasingly clear that a single solution does not suit all applications. For example, it appears to be impossible to find a single appropriate interface, caching policy, file structure, or disk-management strategy. Furthermore, the proliferation of file-system interfaces and abstractions make applications difficult to port. We propose that the traditional functionality of parallel file systems be separated into two components: a fixed core that is standard on all platforms, encapsulating only primitive abstractions and interfaces, and a set of high-level libraries to provide a variety of abstractions and application-programmer interfaces (API's). We present our current and next-generation file systems as examples of this structure. Their features, such as a three-dimensional file structure, strided read and write interfaces, and I/O-node programs, are specifically designed with the flexibility and performance necessary to support a wide range of applications.

Motion planning in velocity affine mechanical systems

NASA Astrophysics Data System (ADS)

Jakubiak, Janusz; Tchoń, Krzysztof; Magiera, Władysław

2010-09-01

We address the motion planning problem in specific mechanical systems whose linear and angular velocities depend affinely on control. The configuration space of these systems encompasses the rotation group, and the motion planning involves the system orientation. Derivation of the motion planning algorithm for velocity affine systems has been inspired by the continuation method. Performance of this algorithm is illustrated with examples of the kinematics of a serial nonholonomic manipulator, the plate-ball kinematics and the attitude control of a rigid body.

TOP 04-1-010 Effectiveness Testing of Mechanical Clearing Systems - Roller Systems Operating in a Straight Path

DTIC Science & Technology

2017-12-04

36 APPENDIX A. TEST LANE DESIGN AND CONFUGURATION ............. A-1 B. EXAMPLE CHECKLISTS AND DATA SHEETS ............. B-1 C. ROLLER...categories and configurations, burial depths, etc.) allow for direct comparison of systems, from legacy systems (fielded) to new designs not having...effectiveness assessment of the SUT, but may indicate shortfall or design deficiency of the SUT in the integration to a specific PM, or a safety flag

Projective-Dual Method for Solving Systems of Linear Equations with Nonnegative Variables

NASA Astrophysics Data System (ADS)

Ganin, B. V.; Golikov, A. I.; Evtushenko, Yu. G.

2018-02-01

In order to solve an underdetermined system of linear equations with nonnegative variables, the projection of a given point onto its solutions set is sought. The dual of this problem—the problem of unconstrained maximization of a piecewise-quadratic function—is solved by Newton's method. The problem of unconstrained optimization dual of the regularized problem of finding the projection onto the solution set of the system is considered. A connection of duality theory and Newton's method with some known algorithms of projecting onto a standard simplex is shown. On the example of taking into account the specifics of the constraints of the transport linear programming problem, the possibility to increase the efficiency of calculating the generalized Hessian matrix is demonstrated. Some examples of numerical calculations using MATLAB are presented.

Implicit Learning of Arithmetic Regularities Is Facilitated by Proximal Contrast

PubMed Central

Prather, Richard W.

2012-01-01

Natural number arithmetic is a simple, powerful and important symbolic system. Despite intense focus on learning in cognitive development and educational research many adults have weak knowledge of the system. In current study participants learn arithmetic principles via an implicit learning paradigm. Participants learn not by solving arithmetic equations, but through viewing and evaluating example equations, similar to the implicit learning of artificial grammars. We expand this to the symbolic arithmetic system. Specifically we find that exposure to principle-inconsistent examples facilitates the acquisition of arithmetic principle knowledge if the equations are presented to the learning in a temporally proximate fashion. The results expand on research of the implicit learning of regularities and suggest that contrasting cases, show to facilitate explicit arithmetic learning, is also relevant to implicit learning of arithmetic. PMID:23119101

[Multi-Family-Groups in Youth Welfare].

PubMed

Ochs, Matthias; Hermans, Björn Enno; Lingnau-Carduck, Anke

2016-01-01

Multi-Family-Groups are an intervention setting, that is mainly applied in the context of systemic therapy and counselling. In this article we introduce some basics of that setting and sketch some specifics and two examples of use for the application in the context of youth welfare.

5 CFR 2606.201 - Requests for access.

Code of Federal Regulations, 2014 CFR

2014-01-01

... and Information Management, Office of Government Ethics, Suite 500, 1201 New York Avenue, NW... specific system of records, it should include other information that will assist in the identification of the records for which access is being requested. Such information may include, for example, the...

Application of Recommended Design Practices for Conceptual Nuclear Fusion Space Propulsion Systems

NASA Technical Reports Server (NTRS)

Williams, Craig H.

2004-01-01

An AIAA Special Project Report was recently produced by AIAA's Nuclear and Future Flight Propulsion Technical Committee and is currently in peer review. The Report provides recommended design practices for conceptual engineering studies of nuclear fusion space propulsion systems. Discussion and recommendations are made on key topics including design reference missions, degree of technological extrapolation and concomitant risk, thoroughness in calculating mass properties (nominal mass properties, weight-growth contingency and propellant margins, and specific impulse), and thoroughness in calculating power generation and usage (power-flow, power contingencies, specific power). The report represents a general consensus of the nuclear fusion space propulsion system conceptual design community and proposes 15 recommendations. This paper expands on the Report by providing specific examples illustrating how to apply each of the recommendations.

MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system

PubMed Central

Kapsimali, Marika; Kloosterman, Wigard P; de Bruijn, Ewart; Rosa, Frederic; Plasterk, Ronald HA; Wilson, Stephen W

2007-01-01

Background MicroRNA (miRNA) encoding genes are abundant in vertebrate genomes but very few have been studied in any detail. Bioinformatic tools allow prediction of miRNA targets and this information coupled with knowledge of miRNA expression profiles facilitates formulation of hypotheses of miRNA function. Although the central nervous system (CNS) is a prominent site of miRNA expression, virtually nothing is known about the spatial and temporal expression profiles of miRNAs in the brain. To provide an overview of the breadth of miRNA expression in the CNS, we performed a comprehensive analysis of the neuroanatomical expression profiles of 38 abundant conserved miRNAs in developing and adult zebrafish brain. Results Our results show miRNAs have a wide variety of different expression profiles in neural cells, including: expression in neuronal precursors and stem cells (for example, miR-92b); expression associated with transition from proliferation to differentiation (for example, miR-124); constitutive expression in mature neurons (miR-124 again); expression in both proliferative cells and their differentiated progeny (for example, miR-9); regionally restricted expression (for example, miR-222 in telencephalon); and cell-type specific expression (for example, miR-218a in motor neurons). Conclusion The data we present facilitate prediction of likely modes of miRNA function in the CNS and many miRNA expression profiles are consistent with the mutual exclusion mode of function in which there is spatial or temporal exclusion of miRNAs and their targets. However, some miRNAs, such as those with cell-type specific expression, are more likely to be co-expressed with their targets. Our data provide an important resource for future functional studies of miRNAs in the CNS. PMID:17711588

Systems engineering interfaces: A model based approach

NASA Astrophysics Data System (ADS)

Fosse, E.; Delp, C. L.

The engineering of interfaces is a critical function of the discipline of Systems Engineering. Included in interface engineering are instances of interaction. Interfaces provide the specifications of the relevant properties of a system or component that can be connected to other systems or components while instances of interaction are identified in order to specify the actual integration to other systems or components. Current Systems Engineering practices rely on a variety of documents and diagrams to describe interface specifications and instances of interaction. The SysML[1] specification provides a precise model based representation for interfaces and interface instance integration. This paper will describe interface engineering as implemented by the Operations Revitalization Task using SysML, starting with a generic case and culminating with a focus on a Flight System to Ground Interaction. The reusability of the interface engineering approach presented as well as its extensibility to more complex interfaces and interactions will be shown. Model-derived tables will support the case studies shown and are examples of model-based documentation products.

Response to Intervention and Continuous School Improvement: Using Data, Vision, and Leadership to Design, Implement, and Evaluate a Schoolwide Prevention System

ERIC Educational Resources Information Center

Bernhardt, Victoria L.; Hebert, Connie L.

2011-01-01

Ensure the success of your school and improve the learning of "all" students by implementing Response-to-Intervention (RTI) as part of a continuous school improvement (CSI) process. This book shows you how to get your entire staff working together to design, implement, and evaluate a schoolwide prevention system. With specific examples, CSI expert…

Casualty Handling Simulation Using the Scenario-based Engineering Process

DTIC Science & Technology

2000-02-28

HERPES ZOSTER ENCEPHALITIS HEPATITIS INFECTIOUS VIRAL ANIMAL BITES/RABIES EXPOSURE MUMPS INFECTIOUS MONONUCLEOSIS TRACHOMA STD-SYPHILIS STD...casualties as they flow through the system. Identifying the proper mix is complicated by many factors, including the specific casualty stream, the...casualties as they flow through the system. Identifying the proper mix is complicated by its dependence on mission types. For example, the types and

Cognitive Processing Hardware Elements

DTIC Science & Technology

2005-01-31

characters. Results will be presented below. 1 4. Recognition of human faces. There are many other possible applications such as facial recognition and...For the experiments in facial recognition , we have used a 3-layer autoassociative neural network having the following specifications: "* The input...using the facial recognition system described in the section above as an example. This system uses an autoassociative neural network containing over 10

SIMULTANEOUS DIFFERENTIAL EQUATION COMPUTER

DOEpatents

Collier, D.M.; Meeks, L.A.; Palmer, J.P.

1960-05-10

A description is given for an electronic simulator for a system of simultaneous differential equations, including nonlinear equations. As a specific example, a homogeneous nuclear reactor system including a reactor fluid, heat exchanger, and a steam boiler may be simulated, with the nonlinearity resulting from a consideration of temperature effects taken into account. The simulator includes three operational amplifiers, a multiplier, appropriate potential sources, and interconnecting R-C networks.

An abstract specification language for Markov reliability models

NASA Technical Reports Server (NTRS)

Butler, R. W.

1985-01-01

Markov models can be used to compute the reliability of virtually any fault tolerant system. However, the process of delineating all of the states and transitions in a model of complex system can be devastatingly tedious and error-prone. An approach to this problem is presented utilizing an abstract model definition language. This high level language is described in a nonformal manner and illustrated by example.

Diversification of energy sources

NASA Technical Reports Server (NTRS)

1975-01-01

The concept of energy source diversification was introduced as a substitution conservation action. The current status and philosophy behind a diversification program is presented in the context of a national energy policy. Advantages, disadvantages (constraints), and methods of implementation for diversification are discussed. The energy source systems for diversification are listed and an example impact assessment is outlined which deals with the water requirements of the specific energy systems.

Bacterial CRISPR: Accomplishments and Prospects

PubMed Central

Peters, Jason M.; Silvis, Melanie R.; Zhao, Dehua; Hawkins, John S.; Gross, Carol A.; Qi, Lei S.

2015-01-01

In this review we briefly describe the development of CRISPR tools for genome editing and control of transcription in bacteria. We focus on the Type II CRISPR/Cas9 system, provide specific examples for use of the system, and highlight the advantages and disadvantages of CRISPR versus other techniques. We suggest potential strategies for combining CRISPR tools with high-throughput approaches to elucidate gene function in bacteria. PMID:26363124

Learning in the Age of Global Information Technology: Development of a Generic Architecture for an Advanced Learning Management System

ERIC Educational Resources Information Center

Watson, Jason; Ahmed, Pervaiz K.

2004-01-01

This paper briefly introduces the trends towards e-learning and amplifies some examples of state of the art systems, pointing out that all of these are, to date, limited by adaptability and shareability of content and that it is necessary for industry to develop and use an inter-operability standard. Uses SCORM specifications to specify the…

Cross-functional systems

NASA Technical Reports Server (NTRS)

Lee, Mark

1991-01-01

Many companies, including Xerox and Texas Instruments, are using cross functional systems to deal with the increasingly complex and competitive business environment. However, few firms within the aerospace industry appear to be aware of the significant benefits that cross functional systems can provide. Those benefits are examined and a flexible methodology is discussed that companies can use to identify and develop cross functional systems that will help improve organizational performance. In addition, some of the managerial issues are addressed that cross functional systems may raise and specific examples are used to explore networking's contributions to cross functional systems.

A Test Generation Framework for Distributed Fault-Tolerant Algorithms

NASA Technical Reports Server (NTRS)

Goodloe, Alwyn; Bushnell, David; Miner, Paul; Pasareanu, Corina S.

2009-01-01

Heavyweight formal methods such as theorem proving have been successfully applied to the analysis of safety critical fault-tolerant systems. Typically, the models and proofs performed during such analysis do not inform the testing process of actual implementations. We propose a framework for generating test vectors from specifications written in the Prototype Verification System (PVS). The methodology uses a translator to produce a Java prototype from a PVS specification. Symbolic (Java) PathFinder is then employed to generate a collection of test cases. A small example is employed to illustrate how the framework can be used in practice.

A RULE-BASED SYSTEM FOR EVALUATING FINAL COVERS FOR HAZARDOUS WASTE LANDFILLS

EPA Science Inventory

This chapter examines how rules are used as a knowledge representation formalism in the domain of hazardous waste management. A specific example from this domain involves performance evaluation of final covers used to close hazardous waste landfills. Final cover design and associ...

Computational Neuroscience.

ERIC Educational Resources Information Center

Sejnowski, Terrence J.; And Others

1988-01-01

Describes the use of brain models to connect the microscopic level accessible by molecular and cellular techniques with the systems level accessible by the study of behavior. Discusses classes of brain models, and specific examples of such models. Evaluates the strengths and weaknesses of using brain modelling to understand human brain function.…

32 CFR 635.1 - General.

Code of Federal Regulations, 2013 CFR

2013-07-01

... life. Specific examples include the social security number (SSN), medical history, home address, and... storage systems providing equal or greater protection may be used in accordance with AR 25-55. (e) Only personnel on official business can have access to areas in which computers are used to store, process or...

32 CFR 635.1 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... life. Specific examples include the social security number (SSN), medical history, home address, and... storage systems providing equal or greater protection may be used in accordance with AR 25-55. (e) Only personnel on official business can have access to areas in which computers are used to store, process or...

32 CFR 635.1 - General.

Code of Federal Regulations, 2012 CFR

2012-07-01

... life. Specific examples include the social security number (SSN), medical history, home address, and... storage systems providing equal or greater protection may be used in accordance with AR 25-55. (e) Only personnel on official business can have access to areas in which computers are used to store, process or...

32 CFR 635.1 - General.

Code of Federal Regulations, 2014 CFR

2014-07-01

... life. Specific examples include the social security number (SSN), medical history, home address, and... storage systems providing equal or greater protection may be used in accordance with AR 25-55. (e) Only personnel on official business can have access to areas in which computers are used to store, process or...

The Use of Polymer Design in Resorbable Colloids

NASA Astrophysics Data System (ADS)

Finne-Wistrand, Anna; Albertsson, Ann-Christine

2006-08-01

During the past decade, researchers in the field of polymer chemistry have developed a wide range of very powerful procedures for constructing ever-more-sophisticated polymers. These methods subsequently have been used in suitable systems to solve specific medical problems. This is complicated, and many key factors such as mechanical properties, biocompatibility, biodegradation, stability, and degradation profile must be considered. Colloid particle systems can be used to solve many biomedical- and pharmaceutical-related problems, and it is expected that nanotechnology can be used to develop these materials, devices, and systems even further. For example, an injectible scaffold system with a defined release and degradation profile has huge potential for the repair and regeneration of damaged tissues. This short, nonexhaustive review presents examples of polymer architecture in resorbable particles that have been compared and tested in biomedical applications. We also discuss the design of polymers for core-shell structures.

A novel methodology for querying web images

NASA Astrophysics Data System (ADS)

Prabhakara, Rashmi; Lee, Ching Cheng

2005-01-01

Ever since the advent of Internet, there has been an immense growth in the amount of image data that is available on the World Wide Web. With such a magnitude of image availability, an efficient and effective image retrieval system is required to make use of this information. This research presents an effective image matching and indexing technique that improvises on existing integrated image retrieval methods. The proposed technique follows a two-phase approach, integrating query by topic and query by example specification methods. The first phase consists of topic-based image retrieval using an improved text information retrieval (IR) technique that makes use of the structured format of HTML documents. It consists of a focused crawler that not only provides for the user to enter the keyword for the topic-based search but also, the scope in which the user wants to find the images. The second phase uses the query by example specification to perform a low-level content-based image match for the retrieval of smaller and relatively closer results of the example image. Information related to the image feature is automatically extracted from the query image by the image processing system. A technique that is not computationally intensive based on color feature is used to perform content-based matching of images. The main goal is to develop a functional image search and indexing system and to demonstrate that better retrieval results can be achieved with this proposed hybrid search technique.

A novel methodology for querying web images

NASA Astrophysics Data System (ADS)

Prabhakara, Rashmi; Lee, Ching Cheng

2004-12-01

Ever since the advent of Internet, there has been an immense growth in the amount of image data that is available on the World Wide Web. With such a magnitude of image availability, an efficient and effective image retrieval system is required to make use of this information. This research presents an effective image matching and indexing technique that improvises on existing integrated image retrieval methods. The proposed technique follows a two-phase approach, integrating query by topic and query by example specification methods. The first phase consists of topic-based image retrieval using an improved text information retrieval (IR) technique that makes use of the structured format of HTML documents. It consists of a focused crawler that not only provides for the user to enter the keyword for the topic-based search but also, the scope in which the user wants to find the images. The second phase uses the query by example specification to perform a low-level content-based image match for the retrieval of smaller and relatively closer results of the example image. Information related to the image feature is automatically extracted from the query image by the image processing system. A technique that is not computationally intensive based on color feature is used to perform content-based matching of images. The main goal is to develop a functional image search and indexing system and to demonstrate that better retrieval results can be achieved with this proposed hybrid search technique.

Overland Mobility of the Forces in the Canadian Environment,

DTIC Science & Technology

1977-01-14

to refer to prior kowledge and this is typified by the I examples of data bank Input In Fig 1. The data ublch Is used may be broadly classifiled as...I tics, suspension as a mobility limiting factor. k. The Enzine Compartment - selection of engines, power require- Seats, load factors, fuel...consumption, specific bulk, specific weight, cooling requirements, parasitic power losses. cooling - system design, fan types and applications, air flow in 3

Modular Research-Based Composably Trustworthy Mission-Oriented Resilient Clouds (MRC2)

DTIC Science & Technology

2016-02-01

obtain in this way, encapsulation is a very promising technique to apply to larger cloud components. For example, ‘ big data ’ processing systems, such...UNITED STATES AIR FORCE  ROME, NY 13441 AIR FORCE MATERIEL COMMAND NOTICE AND SIGNATURE PAGE Using Government drawings, specifications, or other data ...Government formulated or supplied the drawings, specifications, or other data does not license the holder or any other person or corporation; or convey

Report on Ada (Trademark) Program Libraries Workshop Held at Monterey, California on November 1-3, 1983,

DTIC Science & Technology

1983-11-03

capability. An intelligent library management system will be supported by knowledge-based techniques. In fact, until a formal specification of library...from artificial intelligence and information science 2 might also be useful, for example automatic indexing and cataloging schemes, methods for fast...Artificial Intelligence 5:1045-1058, 1977. [Burstall & Goguen 801 Burstall, R. M., and Goguen, J. A. The Semantics of Clear, a Specification Language. In

Developing Medications Targeting Glutamatergic Dysfunction in Autism: Progress to Date

PubMed Central

Fung, Lawrence K.; Hardan, Antonio Y.

2015-01-01

Pharmacologic treatments targeting specific molecular mechanisms relevant for autism spectrum disorder (ASD) are beginning to emerge in early drug development. This article reviews the evidence for the disruption of glutamatergic neurotransmission in animal models of social deficits and summarizes key pre-clinical and clinical efforts in developing pharmacologic interventions based on modulation of glutamatergic systems in individuals with ASD. Understanding the pathobiology of the glutamatergic system has led to the development of new investigational treatments for individuals with ASD. Specific examples of medications that modulate the glutamatergic system in preclinical and clinical studies are described. Finally, we will discuss the limitations of current strategies and future opportunities in developing medications targeting the glutamatergic system for treating individuals with ASD. PMID:26104862

Convergent cross-mapping and pairwise asymmetric inference.

PubMed

McCracken, James M; Weigel, Robert S

2014-12-01

Convergent cross-mapping (CCM) is a technique for computing specific kinds of correlations between sets of times series. It was introduced by Sugihara et al. [Science 338, 496 (2012).] and is reported to be "a necessary condition for causation" capable of distinguishing causality from standard correlation. We show that the relationships between CCM correlations proposed by Sugihara et al. do not, in general, agree with intuitive concepts of "driving" and as such should not be considered indicative of causality. It is shown that the fact that the CCM algorithm implies causality is a function of system parameters for simple linear and nonlinear systems. For example, in a circuit containing a single resistor and inductor, both voltage and current can be identified as the driver depending on the frequency of the source voltage. It is shown that the CCM algorithm, however, can be modified to identify relationships between pairs of time series that are consistent with intuition for the considered example systems for which CCM causality analysis provided nonintuitive driver identifications. This modification of the CCM algorithm is introduced as "pairwise asymmetric inference" (PAI) and examples of its use are presented.

Role of Process Control in Improving Space Vehicle Safety A Space Shuttle External Tank Example

NASA Technical Reports Server (NTRS)

Safie, Fayssal M.; Nguyen, Son C.; Burleson, Keith W.

2006-01-01

Developing a safe and reliable space vehicle requires good design and good manufacturing, or in other words "design it right and build it right". A great design can be hard to build or manufacture mainly due to difficulties related to quality. Specifically, process control can be a challenge. As a result, the system suffers from low quality which leads to low reliability and high system risk. The Space Shuttle has experienced some of those cases, but has overcome these difficulties through extensive redesign efforts and process enhancements. One example is the design of the hot gas temperature sensor on the Space Shuttle Main Engine (SSME), which resulted in failure of the sensor in flight and led to a redesign of the sensor. The most recent example is the Space Shuttle External Tank (ET) Thermal Protection System (TPS) reliability issues that contributed to the Columbia accident. As a result, extensive redesign and process enhancement activities have been performed over the last two years to minimize the sensitivities and difficulties of the manual TPS application process.

PS: A nonprocedural language with data types and modules

NASA Technical Reports Server (NTRS)

Gokhale, M. B.

1986-01-01

The Problem Specification (PS) nonprocedural language is a very high level language for algorithm specification. PS is suitable for nonprogrammers, who can specify a problem using mathematically-oriented equations; for expert programmers, who can prototype different versions of a software system for evaluation; and for those who wish to use specifications for portions (if not all) of a program. PS has data types and modules similar to Modula-2. The compiler generates C code. PS is first shown by example, and then efficiency issues in scheduling and code generation are discussed.

Estimating aquifer transmissivity from specific capacity using MATLAB.

PubMed

McLin, Stephen G

2005-01-01

Historically, specific capacity information has been used to calculate aquifer transmissivity when pumping test data are unavailable. This paper presents a simple computer program written in the MATLAB programming language that estimates transmissivity from specific capacity data while correcting for aquifer partial penetration and well efficiency. The program graphically plots transmissivity as a function of these factors so that the user can visually estimate their relative importance in a particular application. The program is compatible with any computer operating system running MATLAB, including Windows, Macintosh OS, Linux, and Unix. Two simple examples illustrate program usage.

Framework for Architecture Trade Study Using MBSE and Performance Simulation

NASA Technical Reports Server (NTRS)

Ryan, Jessica; Sarkani, Shahram; Mazzuchim, Thomas

2012-01-01

Increasing complexity in modern systems as well as cost and schedule constraints require a new paradigm of system engineering to fulfill stakeholder needs. Challenges facing efficient trade studies include poor tool interoperability, lack of simulation coordination (design parameters) and requirements flowdown. A recent trend toward Model Based System Engineering (MBSE) includes flexible architecture definition, program documentation, requirements traceability and system engineering reuse. As a new domain MBSE still lacks governing standards and commonly accepted frameworks. This paper proposes a framework for efficient architecture definition using MBSE in conjunction with Domain Specific simulation to evaluate trade studies. A general framework is provided followed with a specific example including a method for designing a trade study, defining candidate architectures, planning simulations to fulfill requirements and finally a weighted decision analysis to optimize system objectives.

Method for detection of extremely low concentration

DOEpatents

Andresen, Brian D.; Miller, Fred S.

2002-01-01

An ultratrace detector system for hand-held gas chromatography having high sensitivity, for example, to emissions generated during production of weapons, biological compounds, drugs, etc. The detector system is insensitive to water, air, helium, argon, oxygen, and CO.sub.2. The detector system is basically composed of a hand-held capillary gas chromatography (GC), an insulated heated redox-chamber, a detection chamber, and a vapor trap. For example, the detector system may use gas phase redox reactions and spectral absorption of mercury vapor. The gas chromatograph initially separates compounds that percolate through a bed of heated mercuric oxide (HgO) in a silica--or other metal--aerogel material which acts as an insulator. Compounds easily oxidized by HgO liberate atomic mercury that subsequently pass through a detection chamber which includes a detector cell, such as quartz, that is illuminated with a 254 nm ultra-violet (UV) mercury discharge lamp which generates the exact mercury absorption bands that are used to detect the liberated mercury atoms. Atomic mercury strongly absorbs 254 nm energy is therefore a specific signal for reducing compounds eluting from the capillary GC, whereafter the atomic mercury is trapped for example, in a silicon-aerogel trap.

Ultratrace detector for hand-held gas chromatography

DOEpatents

Andresen, Brian D.; Miller, Fred S.

1999-01-01

An ultratrace detector system for hand-held gas chromatography having high sensitivity, for example, to emissions generated during production of weapons, biological compounds, drugs, etc. The detector system is insensitive to water, air, helium, argon, oxygen, and C0.sub.2. The detector system is basically composed of a hand-held capillary gas chromatography (GC), an insulated heated redox-chamber, a detection chamber, and a vapor trap. For example, the detector system may use gas phase redox reactions and spectral absorption of mercury vapor. The gas chromatograph initially separates compounds that percolate through a bed of heated mercuric oxide (HgO) in a silica--or other metal--aerogel material which acts as an insulator. Compounds easily oxidized by HgO liberate atomic mercury that subsequently pass through a detection chamber which includes a detector cell, such as quartz, that is illuminated with a 254 nm ultra-violet (UV) mercury discharge lamp which generates the exact mercury absorption bands that are used to detect the liberated mercury atoms. Atomic mercury strongly absorbs 254 nm energy is therefore a specific signal for reducing compounds eluting from the capillary GC, whereafter the atomic mercury is trapped for example, in a silicon-aerogel trap.

Nervous systems in 3D: a comparison of Caridean, anomuran, and brachyuran zoea-I (Decapoda).

PubMed

Geiselbrecht, Hannes; Melzer, Roland R

2013-12-01

Using serial semi-thin sections and digital 3D-reconstructions we studied the nervous systems of zoea-I larvae in three decapod species, Hippolyte inermis (Leach, 1815), Porcellana platycheles (Pennant, 1777), and Pachygrapsus marmoratus (Fabricius, 1787). These taxa represent three decapod lineages, that is, Caridea, Anomura, and Brachyura, each characterized by specific zoea-I morphology. Special attention was paid to development of ganglia, neuropil composition, and segmental nerves. In all zoeae studied, the overall elements, for example, the segmental ganglia, their neuropils and most of the nerves of the adult decapod nervous system are present. Ongoing differentiation processes are observable as well, most obvious in segments with well-developed limbs the ganglia are in a more advanced stage of differentiation and more voluminous compared to segments with only limb buds or without externally visible limb anlagen. Intra- and interspecific comparisons indicate that neuromere differentiation thus deviates from a simple anterior-posterior gradient as, for example, posterior thoracic neuromeres are less developed than those of the pleon. In addition, the differences in the progress of the development of ganglia between the studied taxa can best be attributed to heterochronic mechanisms. Taxon and stage-specific morphologies indicate that neuronal architecture reflects both, morphogenesis to the adult stage and specific larval adaptions, and provides sets of characters relevant to understanding the corresponding phylogeny. © 2013 Wiley Periodicals, Inc.

Reforming Teaching Globally. Oxford Studies in Comparative Education

ERIC Educational Resources Information Center

Tatto, Maria Teresa, Ed.

2007-01-01

This book seeks to raise the discussion of globalisation's effects on teacher education, development and work, and its reforms and institutions, to a more theoretical and analytical level, and to provide specific examples in the comparative tradition to illustrate teacher policy in the context of education systems' widespread variability and…

Formal Specification and Verification of Concurrent Programs

DTIC Science & Technology

1993-02-01

of examples from the emerging theory of This book describes operating systems in general programming languages. via the construction of MINIX , a UNIX...look-alike that runs on IBM-PC compatibles. The book con- Wegner72 tains a complete MINIX manual and a complete Wegnerflisting of its C codie. egner

Training and the Change Agent Role Model

ERIC Educational Resources Information Center

Leach, Wesley B.; Owens, Vyrle W.

1973-01-01

The authors discuss the qualities possessed by a model change agent and roles played by him as resident technical participant: analyst, advisor, advocate, systems linker, innovator, and trainer. Besides presenting the teaching plan for change agents, the authors call upon their Peace Corps experiences to provide specific examples of what is…

Examining Autism Spectrum Disorders by Biomarkers: Example from the Oxytocin and Serotonin Systems

ERIC Educational Resources Information Center

Hammock, Elizabeth; Veenstra-VanderWeele, Jeremy; Yan, Zhongyu; Kerr, Travis M.; Morris, Marianna; Anderson, George M.; Carter, C. Sue; Cook, Edwin H.; Jacob, Suma

2012-01-01

Objective: Autism spectrum disorder (ASD) is a heritable but highly heterogeneous neuropsychiatric syndrome, which poses challenges for research relying solely on behavioral symptoms or diagnosis. Examining biomarkers may give us ways to identify individuals who demonstrate specific developmental trajectories and etiological factors related to…

A GUIDE TO INSTRUCTIONAL TELEVISION.

ERIC Educational Resources Information Center

DIAMOND, ROBERT M., ED.

THIS IS A GUIDE DESIGNED AS A SINGLE REFERENCE FOR ADMINISTRATORS, TEACHERS, STUDENTS, AND LAYMEN INTERESTED IN TELEVISION FOR A SPECIFIC SCHOOL OR SCHOOL SYSTEM. FOUR EXAMPLES OF SINGLE-ROOM TELEVISION ARE GIVEN AND SUCCESSFUL APPLICATIONS OF STUDIO TELEVISION ARE PRESENTED. ITS USE IN GUIDANCE AND IN ADMINISTRATION IS EXPLAINED. THE PROBLEMS…

40 CFR 1054.205 - What must I include in my application?

Code of Federal Regulations, 2012 CFR

2012-07-01

... emission family's specifications and other basic parameters of the engine's design and emission controls. List the fuel type on which your engines are designed to operate (for example, all-season gasoline... emission control systems operate. Describe the evaporative emission controls and show how your design will...

40 CFR 1054.205 - What must I include in my application?

Code of Federal Regulations, 2011 CFR

2011-07-01

... emission family's specifications and other basic parameters of the engine's design and emission controls. List the fuel type on which your engines are designed to operate (for example, all-season gasoline... emission control systems operate. Describe the evaporative emission controls and show how your design will...

40 CFR 1054.205 - What must I include in my application?

Code of Federal Regulations, 2010 CFR

2010-07-01

... emission family's specifications and other basic parameters of the engine's design and emission controls. List the fuel type on which your engines are designed to operate (for example, all-season gasoline... emission control systems operate. Describe the evaporative emission controls and show how your design will...

40 CFR 1054.205 - What must I include in my application?

Code of Federal Regulations, 2013 CFR

2013-07-01

... emission family's specifications and other basic parameters of the engine's design and emission controls. List the fuel type on which your engines are designed to operate (for example, all-season gasoline... emission control systems operate. Describe the evaporative emission controls and show how your design will...

40 CFR 1054.205 - What must I include in my application?

Code of Federal Regulations, 2014 CFR

2014-07-01

... emission family's specifications and other basic parameters of the engine's design and emission controls. List the fuel type on which your engines are designed to operate (for example, all-season gasoline... emission control systems operate. Describe the evaporative emission controls and show how your design will...

26 CFR 1.482-2A - Determination of taxable income in specific situations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... property. Example 3. In 1967 X undertakes to develop product M in its research and development department... likely to remain unique, (e) The degree and duration of protection afforded to the property under the..., systems, procedures, campaigns, surveys, studies, forecasts, estimates, customer lists, technical data...

Options to Injustice: The Battered Woman.

ERIC Educational Resources Information Center

Fine, Michelle

Cultural heritage, societal values, role expectations, the legal system, and sex stereotyping are examples of the multi-level collusion of forces which keep victims of domestic violence from challenging the legitimacy of the abusive behavior. Powerless subjects of injustice, specifically battered women, who are eager to maintain high self-regard…

Methods for Probing Magnetic Films with Neutrons

NASA Astrophysics Data System (ADS)

Kozhevnikov, S. V.; Ott, F.; Radu, F.

2018-03-01

We review various methods in the investigation of magnetic films with neutrons, including those based on the effects of Larmor precession, Zeeman spatial splitting of the beam, neutron spin resonance, and polarized neutron channeling. The underlying principles, examples of the investigated systems, specific features, applications, and perspectives of these methods are discussed.

The Unexplored Impact of IPv6 on Intrusion Detection Systems

DTIC Science & Technology

2012-03-01

of cross-NIDS, standardized, rule sets such as SNORT’s VRT [23]. • Continuously monitor vulnerability or exploit development sites. For example, the...and BRO polices should be written to enhance detection. The bolstering of built-in databases and repositories such as VRT [23] for specific IPv6 issues

Steepest entropy ascent for two-state systems with slowly varying Hamiltonians

NASA Astrophysics Data System (ADS)

Militello, Benedetto

2018-05-01

The steepest entropy ascent approach is considered and applied to two-state systems. When the Hamiltonian of the system is time-dependent, the principle of maximum entropy production can still be exploited; arguments to support this fact are given. In the limit of slowly varying Hamiltonians, which allows for the adiabatic approximation for the unitary part of the dynamics, the system exhibits significant robustness to the thermalization process. Specific examples such as a spin in a rotating field and a generic two-state system undergoing an avoided crossing are considered.

Sensing, Control, and System Integration for Autonomous Vehicles: A Series of Challenges

NASA Astrophysics Data System (ADS)

Özgüner, Ümit; Redmill, Keith

One of the important examples of mechatronic systems can be found in autonomous ground vehicles. Autonomous ground vehicles provide a series of challenges in sensing, control and system integration. In this paper we consider off-road autonomous vehicles, automated highway systems and urban autonomous driving and indicate the unifying aspects. We specifically consider our own experience during the last twelve years in various demonstrations and challenges in attempting to identify unifying themes. Such unifying themes can be observed in basic hierarchies, hybrid system control approaches and sensor fusion techniques.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roos, E.; Maier, V.; Nagel, G.

The break preclusion concept is based on {open_quotes}KTA rules{close_quotes}, {open_quotes}RSK guidelines{close_quotes} and {open_quotes}Rahmenspeziflkation Basissicherheit{close_quotes}. These fundamental rules containing for example requirements on material, design, calculation, manufacturing and testing procedures are explained and the technical realisation is shown by means of examples. The proof of the quality of these piping systems can be executed by means of fracture mechanics calculations by showing that in every case the leakage monitoring system already detect cracks which are clearly smaller than the critical crack. Thus the leak before break behavior and the break preclusion concept is implicitly affirmed. In order to further diminish conservativitiesmore » in the fracture mechanics procedures, specific research projects are executed which are explained in this contribution.« less

Application of THz Vibrational Spectroscopy to Molecular Characterization and the Theoretical Fundamentals: An Illustration Using Saccharide Molecules.

PubMed

Zhang, Feng; Wang, Houng-Wei; Tominaga, Keisuke; Hayashi, Michitoshi; Hasunuma, Tomohisa; Kondo, Akihiko

2017-02-01

This work illustrates several theoretical fundamentals for the application of THz vibrational spectroscopy to molecular characterization in the solid state using two different types of saccharide systems as examples. Four subjects have been specifically addressed: (1) the qualitative differences in the molecular vibrational signatures monitored by THz and mid-IR vibrational spectroscopy; (2) the selection rules for THz vibrational spectroscopy as applied to crystalline and amorphous systems; (3) a normal mode simulation, using α-l-xylose as an example; and (4) a rigorous mode analysis to quantify the percentage contributions of the intermolecular and intramolecular vibrations to the normal mode of interest. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Social Tagging of Mission Data

NASA Technical Reports Server (NTRS)

Norris, Jeffrey S.; Wallick, Michael N.; Joswig, Joseph C.; Powell, Mark W.; Torres, Recaredo J.; Mittman, David S.; Abramyan, Lucy; Crockett, Thomas M.; Shams, Khawaja S.; Fox, Jason M.;

Specific metal recognition in nickel trafficking

PubMed Central

Higgins, Khadine A.; Carr, Carolyn E.; Maroney, Michael J.

2012-01-01

Nickel is an essential metal for a number of bacterial species that have developed systems for acquiring, delivering and incorporating the metal into target enzymes, and controlling the levels of nickel in cells to avoid toxic effects. As with other transition metals, these trafficking systems must be able to distinguish between the desired metal and other transition metal ions with similar physical and chemical properties. Because there are few enzymes (targets) that require nickel for activity (e.g., E. coli traffics nickel for hydrogenases made under anaerobic conditions and H. pylori requires nickel for hydrogenase and urease that are essential for acid viability), the ‘traffic pattern’ for nickel is relatively simple, and nickel trafficking therefore presents an opportunity to examine a system for the mechanisms that are used to distinguish nickel from other metals. In this review, we describe the details known for examples of uptake permeases, metallochaperones and proteins involved in metallocenter assembly, and nickel metalloregulators. We also illustrate the variety of mechanisms, including molecular recognition in the case of NikA protein and examples of allosteric regulation for HypA, NikR and RcnR, employed to generate specific biological responses to nickel ions. PMID:22970729

The role of population monitoring in the management of North American waterfowl

USGS Publications Warehouse

Nichols, J.D.; Williams, B.K.; Johnson, F.A.

2000-01-01

Despite the effort and expense devoted to large-scale monitoring programs, few existing programs have been designed with specific objectives in mind and few permit strong inferences about the dynamics of monitored systems. The waterfowl population monitoring programs of the U.S. Fish and Wildlife Service, Canadian Wildlife Service and state and provincial agencies provide a nice example with respect to program objectives, design and implementation. The May Breeding Grounds Survey provides an estimate of system state (population size) that serves two primary purposes in the adaptive management process: identifying the appropriate time-specific management actions and updating the information state (model weights) by providing a basis for evaluating predictions of competing models. Other waterfowl monitoring programs (e.g., banding program, hunter questionnaire survey, parts collection survey, winter survey) provide estimates of vital rates (rates of survival, reproduction and movement) associated with system dynamics and variables associated with management objectives (e.g., harvest). The reliability of estimates resulting from monitoring programs depends strongly on whether considerations about spatial variation and detection probability have been adequately incorporated into program design and implementation. Certain waterfowl surveys again provide nice examples of monitoring programs that incorporate these considerations.

Certification of highly complex safety-related systems.

PubMed

Reinert, D; Schaefer, M

1999-01-01

The BIA has now 15 years of experience with the certification of complex electronic systems for safety-related applications in the machinery sector. Using the example of machining centres this presentation will show the systematic procedure for verifying and validating control systems using Application Specific Integrated Circuits (ASICs) and microcomputers for safety functions. One section will describe the control structure of machining centres with control systems using "integrated safety." A diverse redundant architecture combined with crossmonitoring and forced dynamization is explained. In the main section the steps of the systematic certification procedure are explained showing some results of the certification of drilling machines. Specification reviews, design reviews with test case specification, statistical analysis, and walk-throughs are the analytical measures in the testing process. Systematic tests based on the test case specification, Electro Magnetic Interference (EMI), and environmental testing, and site acceptance tests on the machines are the testing measures for validation. A complex software driven system is always undergoing modification. Most of the changes are not safety-relevant but this has to be proven. A systematic procedure for certifying software modifications is presented in the last section of the paper.

Endogenous Biologically Inspired Art of Complex Systems.

PubMed

Ji, Haru; Wakefield, Graham

2016-01-01

Since 2007, Graham Wakefield and Haru Ji have looked to nature for inspiration as they have created a series of "artificial natures," or interactive visualizations of biologically inspired complex systems that can evoke nature-like aesthetic experiences within mixed-reality art installations. This article describes how they have applied visualization, sonification, and interaction design in their work with artificial ecosystems and organisms using specific examples from their exhibited installations.

Approach to developing reliable space reactor power systems

NASA Technical Reports Server (NTRS)

Mondt, Jack F.; Shinbrot, Charles H.

1991-01-01

During Phase II, the Engineering Development Phase, the SP-100 Project has defined and is pursuing a new approach to developing reliable power systems. The approach to developing such a system during the early technology phase is described along with some preliminary examples to help explain the approach. Developing reliable components to meet space reactor power system requirements is based on a top-down systems approach which includes a point design based on a detailed technical specification of a 100-kW power system. The SP-100 system requirements implicitly recognize the challenge of achieving a high system reliability for a ten-year lifetime, while at the same time using technologies that require very significant development efforts. A low-cost method for assessing reliability, based on an understanding of fundamental failure mechanisms and design margins for specific failure mechanisms, is being developed as part of the SP-100 Program.

Assessment of distributed photovoltair electric-power systems

NASA Astrophysics Data System (ADS)

Neal, R. W.; Deduck, P. F.; Marshall, R. N.

1982-10-01

The development of a methodology to assess the potential impacts of distributed photovoltaic (PV) systems on electric utility systems, including subtransmission and distribution networks, and to apply that methodology to several illustrative examples was developed. The investigations focused upon five specific utilities. Impacts upon utility system operations and generation mix were assessed using accepted utility planning methods in combination with models that simulate PV system performance and life cycle economics. Impacts on the utility subtransmission and distribution systems were also investigated. The economic potential of distributed PV systems was investigated for ownership by the utility as well as by the individual utility customer.

Metabolic systems biology: a brief primer.

PubMed

Edwards, Lindsay M

2017-05-01

In the early to mid-20th century, reductionism as a concept in biology was challenged by key thinkers, including Ludwig von Bertalanffy. He proposed that living organisms were specific examples of complex systems and, as such, they should display characteristics including hierarchical organisation and emergent behaviour. Yet the true study of complete biological systems (for example, metabolism) was not possible until technological advances that occurred 60 years later. Technology now exists that permits the measurement of complete levels of the biological hierarchy, for example the genome and transcriptome. The complexity and scale of these data require computational models for their interpretation. The combination of these - systems thinking, high-dimensional data and computation - defines systems biology, typically accompanied by some notion of iterative model refinement. Only sequencing-based technologies, however, offer full coverage. Other 'omics' platforms trade coverage for sensitivity, although the densely connected nature of biological networks suggests that full coverage may not be necessary. Systems biology models are often characterised as either 'bottom-up' (mechanistic) or 'top-down' (statistical). This distinction can mislead, as all models rely on data and all are, to some degree, 'middle-out'. Systems biology has matured as a discipline, and its methods are commonplace in many laboratories. However, many challenges remain, especially those related to large-scale data integration. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

TraceContract

NASA Technical Reports Server (NTRS)

Kavelund, Klaus; Barringer, Howard

2012-01-01

TraceContract is an API (Application Programming Interface) for trace analysis. A trace is a sequence of events, and can, for example, be generated by a running program, instrumented appropriately to generate events. An event can be any data object. An example of a trace is a log file containing events that a programmer has found important to record during a program execution. Trace - Contract takes as input such a trace together with a specification formulated using the API and reports on any violations of the specification, potentially calling code (reactions) to be executed when violations are detected. The software is developed as an internal DSL (Domain Specific Language) in the Scala programming language. Scala is a relatively new programming language that is specifically convenient for defining such internal DSLs due to a number of language characteristics. This includes Scala s elegant combination of object-oriented and functional programming, a succinct notation, and an advanced type system. The DSL offers a combination of data-parameterized state machines and temporal logic, which is novel. As an extension of Scala, it is a very expressive and convenient log file analysis framework.

Modeling, Analyzing, and Mitigating Dissonance Between Alerting Systems

NASA Technical Reports Server (NTRS)

Song, Lixia; Kuchar, James K.

2003-01-01

Alerting systems are becoming pervasive in process operations, which may result in the potential for dissonance or conflict in information from different alerting systems that suggests different threat levels and/or actions to resolve hazards. Little is currently available to help in predicting or solving the dissonance problem. This thesis presents a methodology to model and analyze dissonance between alerting systems, providing both a theoretical foundation for understanding dissonance and a practical basis from which specific problems can be addressed. A state-space representation of multiple alerting system operation is generalized that can be tailored across a variety of applications. Based on the representation, two major causes of dissonance are identified: logic differences and sensor error. Additionally, several possible types of dissonance are identified. A mathematical analysis method is developed to identify the conditions for dissonance originating from logic differences. A probabilistic analysis methodology is developed to estimate the probability of dissonance originating from sensor error, and to compare the relative contribution to dissonance of sensor error against the contribution from logic differences. A hybrid model, which describes the dynamic behavior of the process with multiple alerting systems, is developed to identify dangerous dissonance space, from which the process can lead to disaster. Methodologies to avoid or mitigate dissonance are outlined. Two examples are used to demonstrate the application of the methodology. First, a conceptual In-Trail Spacing example is presented. The methodology is applied to identify the conditions for possible dissonance, to identify relative contribution of logic difference and sensor error, and to identify dangerous dissonance space. Several proposed mitigation methods are demonstrated in this example. In the second example, the methodology is applied to address the dissonance problem between two air traffic alert and avoidance systems: the existing Traffic Alert and Collision Avoidance System (TCAS) vs. the proposed Airborne Conflict Management system (ACM). Conditions on ACM resolution maneuvers are identified to avoid dynamic dissonance between TCAS and ACM. Also included in this report is an Appendix written by Lee Winder about recent and continuing work on alerting systems design. The application of Markov Decision Process (MDP) theory to complex alerting problems is discussed and illustrated with an abstract example system.

Cartographic services contract...for everything geographic

USGS Publications Warehouse

,

2003-01-01

The U.S. Geological Survey's (USGS) Cartographic Services Contract (CSC) is used to award work for photogrammetric and mapping services under the umbrella of Architect-Engineer (A&E) contracting. The A&E contract is broad in scope and can accommodate any activity related to standard, nonstandard, graphic, and digital cartographic products. Services provided may include, but are not limited to, photogrammetric mapping and aerotriangulation; orthophotography; thematic mapping (for example, land characterization); analog and digital imagery applications; geographic information systems development; surveying and control acquisition, including ground-based and airborne Global Positioning System; analog and digital image manipulation, analysis, and interpretation; raster and vector map digitizing; data manipulations (for example, transformations, conversions, generalization, integration, and conflation); primary and ancillary data acquisition (for example, aerial photography, satellite imagery, multispectral, multitemporal, and hyperspectral data); image scanning and processing; metadata production, revision, and creation; and production or revision of standard USGS products defined by formal and informal specification and standards, such as those for digital line graphs, digital elevation models, digital orthophoto quadrangles, and digital raster graphics.

Human adaptive immune system Rag2-/-gamma(c)-/- mice.

PubMed

Chicha, Laurie; Tussiwand, Roxane; Traggiai, Elisabetta; Mazzucchelli, Luca; Bronz, Lucio; Piffaretti, Jean-Claude; Lanzavecchia, Antonio; Manz, Markus G

2005-06-01

Although many biologic principles are conserved in mice and humans, species-specific differences exist, for example, in susceptibility and response to pathogens, that often do not allow direct implementation of findings in experimental mice to humans. Research in humans, however, for ethical and practical reasons, is largely restricted to in vitro assays that lack components and the complexity of a living organism. To nevertheless study the human hematopoietic and immune system in vivo, xenotransplantation assays have been developed that substitute human components to small animals. Here, we summarize our recent findings that transplantation of human cord blood CD34(+) cells to newborn Rag2(-/-)gamma(c)(-/-) mice leads to de novo development of major functional components of the human adaptive immune system. These human adaptive immune system Rag2(-/-)gamma(c)(-/-) (huAIS-RG) mice can now be used as a technically straightforward preclinical model to evaluate in vivo human adaptive immune system development as well as immune responses, for example, to vaccines or live infectious pathogens.

Molecular biomimetics: GEPI-based biological routes to technology.

PubMed

Tamerler, Candan; Khatayevich, Dmitriy; Gungormus, Mustafa; Kacar, Turgay; Oren, E Emre; Hnilova, Marketa; Sarikaya, Mehmet

2010-01-01

In nature, the viability of biological systems is sustained via specific interactions among the tens of thousands of proteins, the major building blocks of organisms from the simplest single-celled to the most complex multicellular species. Biomolecule-material interaction is accomplished with molecular specificity and efficiency leading to the formation of controlled structures and functions at all scales of dimensional hierarchy. Through evolution, Mother Nature developed molecular recognition by successive cycles of mutation and selection. Molecular specificity of probe-target interactions, e.g., ligand-receptor, antigen-antibody, is always based on specific peptide molecular recognition. Using biology as a guide, we can now understand, engineer, and control peptide-material interactions and exploit them as a new design tool for novel materials and systems. We adapted the protocols of combinatorially designed peptide libraries, via both cell surface or phage display methods; using these we select short peptides with specificity to a variety of practical materials. These genetically engineered peptides for inorganics (GEPI) are then studied experimentally to establish their binding kinetics and surface stability. The bound peptide structure and conformations are interrogated both experimentally and via modeling, and self-assembly characteristics are tested via atomic force microscopy. We further engineer the peptide binding and assembly characteristics using a computational biomimetics approach where bioinformatics based peptide-sequence similarity analysis is developed to design higher generation function-specific peptides. The molecular biomimetic approach opens up new avenues for the design and utilization of multifunctional molecular systems in a wide-range of applications from tissue engineering, disease diagnostics, and therapeutics to various areas of nanotechnology where integration is required among inorganic, organic and biological materials. Here, we describe lessons from biology with examples of protein-mediated functional biological materials, explain how novel peptides can be designed with specific affinity to inorganic solids using evolutionary engineering approaches, give examples of their potential utilizations in technology and medicine, and, finally, provide a summary of challenges and future prospects. (c) 2010 Wiley Periodicals, Inc.

A Simulation and Modeling Framework for Space Situational Awareness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olivier, S S

This paper describes the development and initial demonstration of a new, integrated modeling and simulation framework, encompassing the space situational awareness enterprise, for quantitatively assessing the benefit of specific sensor systems, technologies and data analysis techniques. The framework is based on a flexible, scalable architecture to enable efficient, physics-based simulation of the current SSA enterprise, and to accommodate future advancements in SSA systems. In particular, the code is designed to take advantage of massively parallel computer systems available, for example, at Lawrence Livermore National Laboratory. The details of the modeling and simulation framework are described, including hydrodynamic models of satellitemore » intercept and debris generation, orbital propagation algorithms, radar cross section calculations, optical brightness calculations, generic radar system models, generic optical system models, specific Space Surveillance Network models, object detection algorithms, orbit determination algorithms, and visualization tools. The use of this integrated simulation and modeling framework on a specific scenario involving space debris is demonstrated.« less

An overview of very high level software design methods

NASA Technical Reports Server (NTRS)

Asdjodi, Maryam; Hooper, James W.

1988-01-01

Very High Level design methods emphasize automatic transfer of requirements to formal design specifications, and/or may concentrate on automatic transformation of formal design specifications that include some semantic information of the system into machine executable form. Very high level design methods range from general domain independent methods to approaches implementable for specific applications or domains. Applying AI techniques, abstract programming methods, domain heuristics, software engineering tools, library-based programming and other methods different approaches for higher level software design are being developed. Though one finds that a given approach does not always fall exactly in any specific class, this paper provides a classification for very high level design methods including examples for each class. These methods are analyzed and compared based on their basic approaches, strengths and feasibility for future expansion toward automatic development of software systems.

Techniques for Computation of Frequency Limited H∞ Norm

NASA Astrophysics Data System (ADS)

Haider, Shafiq; Ghafoor, Abdul; Imran, Muhammad; Fahad Mumtaz, Malik

2018-01-01

Traditional H ∞ norm depicts peak system gain over infinite frequency range, but many applications like filter design, model order reduction and controller design etc. require computation of peak system gain over specific frequency interval rather than infinite range. In present work, new computationally efficient techniques for computation of H ∞ norm over frequency limited interval are proposed. Proposed techniques link norm computation with maximum singular value of the system in limited frequency interval. Numerical examples are incorporated to validate the proposed concept.

Designing for Annual Spacelift Performance

NASA Technical Reports Server (NTRS)

McCleskey, Carey M.; Zapata, Edgar

2017-01-01

This paper presents a methodology for approaching space launch system design from a total architectural point of view. This different approach to conceptual design is contrasted with traditional approaches that focus on a single set of metrics for flight system performance, i.e., payload lift per flight, vehicle mass, specific impulse, etc. The approach presented works with a larger set of metrics, including annual system lift, or "spacelift" performance. Spacelift performance is more inclusive of the flight production capability of the total architecture, i.e., the flight and ground systems working together as a whole to produce flights on a repeated basis. In the proposed methodology, spacelift performance becomes an important design-for-support parameter for flight system concepts and truly advanced spaceport architectures of the future. The paper covers examples of existing system spacelift performance as benchmarks, points out specific attributes of space transportation systems that must be greatly improved over these existing designs, and outlines current activity in this area.

Monitoring Java Programs with Java PathExplorer

NASA Technical Reports Server (NTRS)

Havelund, Klaus; Rosu, Grigore; Clancy, Daniel (Technical Monitor)

2001-01-01

We present recent work on the development Java PathExplorer (JPAX), a tool for monitoring the execution of Java programs. JPAX can be used during program testing to gain increased information about program executions, and can potentially furthermore be applied during operation to survey safety critical systems. The tool facilitates automated instrumentation of a program's late code which will then omit events to an observer during its execution. The observer checks the events against user provided high level requirement specifications, for example temporal logic formulae, and against lower level error detection procedures, for example concurrency related such as deadlock and data race algorithms. High level requirement specifications together with their underlying logics are defined in the Maude rewriting logic, and then can either be directly checked using the Maude rewriting engine, or be first translated to efficient data structures and then checked in Java.

a Representation-Driven Ontology for Spatial Data Quality Elements, with Orthoimagery as Running Example

NASA Astrophysics Data System (ADS)

Hangouët, J.-F.

2015-08-01

The many facets of what is encompassed by such an expression as "quality of spatial data" can be considered as a specific domain of reality worthy of formal description, i.e. of ontological abstraction. Various ontologies for data quality elements have already been proposed in literature. Today, the system of quality elements is most generally used and discussed according to the configuration exposed in the "data dictionary for data quality" of international standard ISO 19157. Our communication proposes an alternative view. This is founded on a perspective which focuses on the specificity of spatial data as a product: the representation perspective, where data in the computer are meant to show things of the geographic world and to be interpreted as such. The resulting ontology introduces new elements, the usefulness of which will be illustrated by orthoimagery examples.

Religion, bioethics and nursing practice.

PubMed

Fowler, Marsha D

2009-07-01

This article calls nursing to engage in the study of religions and identifies six considerations that arise in religious studies and the ways in which religious faith is expressed. It argues that whole-person care cannot be realized, neither can there be a complete understanding of bioethics theory and decision making, without a rigorous understanding of religious-ethical systems. Because religious traditions differ in their cosmology, ontology, epistemology, aesthetic, and ethical methods, and because religious subtraditions interact with specific cultures, each religion and subtradition has something distinctive to offer to ethical discourse. A brief example is drawn from Native American religions, specifically their view of ;speech' and ;words'. Although the example is particular to an American context, it is intended to demonstrate a more general principle that an understanding of religion per se can yield new insights for bioethics.

Child-Specific Exposure Scenarios Examples (Final Report)

EPA Science Inventory

EPA announced the availability of the final report, Child-Specific Exposure Scenarios Examples. This report is intended to be a companion document to the Exposure Factors Handbook (U.S. EPA 2011). The example scenarios were compiled from questions and inquiries r...

Space engine safety system

NASA Technical Reports Server (NTRS)

Maul, William A.; Meyer, Claudia M.

1991-01-01

A rocket engine safety system was designed to initiate control procedures to minimize damage to the engine or vehicle or test stand in the event of an engine failure. The features and the implementation issues associated with rocket engine safety systems are discussed, as well as the specific concerns of safety systems applied to a space-based engine and long duration space missions. Examples of safety system features and architectures are given, based on recent safety monitoring investigations conducted for the Space Shuttle Main Engine and for future liquid rocket engines. Also, the general design and implementation process for rocket engine safety systems is presented.

Luminescent Silica Nanoparticles for cancer diagnosis

PubMed Central

Montalti, Marco; Petrizza, Luca; Rampazzo, Enrico; Zaccheroni, Nelsi; Marchiò, Serena

2015-01-01

Fluorescence imaging techniques are becoming essential in preclinical investigations, and the research of suitable tools for in vivo measurements is gaining more and more importance and attention. Nanotechnology entered the field to try to find solutions for many limitation at the state of the art, and luminescent nanoparticles (NPs) are one of the most promising materials proposed for future diagnostic implementation. NPs constitute also a versatile platform that can allow facile multi-functionalization to perform multimodal imaging or theranostic (simultaneous diagnosis and therapy). In this contribution we have focussed our attention only on dye doped silica or silica-based NPs conjugated with targeting moieties to enable specific cancer cells imaging and differentiation, even if also a few non targeted systems have been cited and discussed for completeness. We have summarized common synthetic approaches to these materials and then surveyed the most recent imaging applications of silica-based nanoparticles in cancer. The field of theranostic is so important and stimulating that, even if it is not the central topic of this paper, we have included some significant examples. We have then concluded with short hints on systems already in clinical trials and examples of specific applications in children tumours. This review tries to describe and discuss, through focussed examples, the great potentialities of these materials in the medical field, with the aim to encourage further research to implement applications that are still rare. PMID:23458621

Expert systems identify fossils and manage large paleontological databases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beightol, D.S.; Conrad, M.A.

EXPAL is a computer program permitting creation and maintenance of comprehensive databases in marine paleontology. It is designed to assist specialists and non-specialists. EXPAL includes a powerful expert system based on the morphological descriptors specific to a given group of fossils. The expert system may be used, for example, to describe and automatically identify an unknown specimen. EXPAL was first applied to Dasycladales (Calcareous green algae). Projects are under way for corresponding expert systems and databases on planktonic foraminifers and calpionellids. EXPAL runs on an IBM XT or compatible microcomputer.

Real-time Avatar Animation from a Single Image.

PubMed

Saragih, Jason M; Lucey, Simon; Cohn, Jeffrey F

2011-01-01

A real time facial puppetry system is presented. Compared with existing systems, the proposed method requires no special hardware, runs in real time (23 frames-per-second), and requires only a single image of the avatar and user. The user's facial expression is captured through a real-time 3D non-rigid tracking system. Expression transfer is achieved by combining a generic expression model with synthetically generated examples that better capture person specific characteristics. Performance of the system is evaluated on avatars of real people as well as masks and cartoon characters.

Real-time Avatar Animation from a Single Image

PubMed Central

Saragih, Jason M.; Lucey, Simon; Cohn, Jeffrey F.

2014-01-01

A real time facial puppetry system is presented. Compared with existing systems, the proposed method requires no special hardware, runs in real time (23 frames-per-second), and requires only a single image of the avatar and user. The user’s facial expression is captured through a real-time 3D non-rigid tracking system. Expression transfer is achieved by combining a generic expression model with synthetically generated examples that better capture person specific characteristics. Performance of the system is evaluated on avatars of real people as well as masks and cartoon characters. PMID:24598812

Optical methods for the optimization of system SWaP-C using aspheric components and advanced optical polymers

NASA Astrophysics Data System (ADS)

Zelazny, Amy; Benson, Robert; Deegan, John; Walsh, Ken; Schmidt, W. David; Howe, Russell

2013-06-01

We describe the benefits to camera system SWaP-C associated with the use of aspheric molded glasses and optical polymers in the design and manufacture of optical components and elements. Both camera objectives and display eyepieces, typical for night vision man-portable EO/IR systems, are explored. We discuss optical trade-offs, system performance, and cost reductions associated with this approach in both visible and non-visible wavebands, specifically NIR and LWIR. Example optical models are presented, studied, and traded using this approach.

Implementing Attachment and Biobehavioral Catch-Up with birth parents: Rationale and case example.

PubMed

Hoye, Julie R; Dozier, Mary

2018-05-25

Attachment and Biobehavioral Catch-Up (ABC) is an intervention designed for vulnerable children and their parents. This intervention enhances parental sensitivity and nurturance with the goal of promoting secure, organized attachments and strong self-regulatory capabilities among children. Here, we provide a brief rationale for the need for such interventions to be delivered to parent-child dyads in the child welfare system. Next, we review specific intervention targets of ABC. We include a case example of two birth parents and their daughter who became involved in Child Protective Services due to domestic violence. © 2018 Wiley Periodicals, Inc.

Financial Reporting under GASB Statement No. 34 and ASBO International Certificate of Excellence Financial Reporting.

ERIC Educational Resources Information Center

Heinfeld, Gary

This guide presents a financial model that affects all governmental entities that issue financial statements in conformity with Generally Accepted Accounting Principles (GAAP). The model was prepared to provide school business officials specific examples of school system financial-statement presentations. The guide is divided into six chapters.…

Minorities and the Quest for Human Dignity.

ERIC Educational Resources Information Center

de Ortego y Gasca, Felipe

Distorted images of American minorities are reflected in all spheres of American life, including academic and public policies. Some specific examples include: (1) Harvard's 1922 quota system for Jews, the university's pattern of white supremacy, and bias in its scholarly research; (2) the relocation of Japanese Americans during World War II; (3)…

Simulated Classrooms and Artificial Students: The Potential Effects of New Technologies on Teacher Education.

ERIC Educational Resources Information Center

Brown, Abbie Howard

1999-01-01

Describes and discusses how simulation activities can be used in teacher education to augment the traditional field-experience approach, focusing on artificial intelligence, virtual reality, and intelligent tutoring systems. Includes an overview of simulation as a teaching and learning strategy and specific examples of high-technology simulations…

Instrument and Survey Analysis Technical Report: Program Implementation Survey. Technical Report #1112

ERIC Educational Resources Information Center

Alonzo, Julie; Tindal, Gerald

2011-01-01

This technical document provides guidance to educators on the creation and interpretation of survey instruments, particularly as they relate to an analysis of program implementation. Illustrative examples are drawn from a survey of educators related to the use of the easyCBM learning system. This document includes specific sections on…

Exodus from Pandemonium: Human Abuse and Reformation of Public Policy.

ERIC Educational Resources Information Center

Blatt, Burton

As a result of personal observations of state institutions for the mentally handicapped, the author describes the tragic and inhuman conditions with vivid examples of specific patients and incidents. The account further explores the entire concept of human abuse which is propagated both by social institutions (such as the prison system) and by…

The Impact of Providing Performance Feedback to Teachers and Principals. NCEE 2018-4001

ERIC Educational Resources Information Center

Garet, Michael S.; Wayne, Andrew J.; Brown, Seth; Rickles, Jordan; Song, Mengli; Manzeske, David

2017-01-01

Educator performance evaluation systems are a potential tool for improving student achievement by increasing the effectiveness of the educator workforce. For example, recent research suggests that giving more frequent, specific feedback on classroom practice may lead to improvements in teacher performance and student achievement. This report is…

The Impact of Providing Performance Feedback to Teachers and Principals. Executive Summary. NCEE 2018-4000

ERIC Educational Resources Information Center

Garet, Michael S.; Wayne, Andrew J.; Brown, Seth; Rickles, Jordan; Song, Mengli; Manzeske, David

2017-01-01

Educator performance evaluation systems are a potential tool for improving student achievement by increasing the effectiveness of the educator workforce. For example, recent research suggests that giving more frequent, specific feedback on classroom practice may lead to improvements in teacher performance and student achievement. This report is…

Feedback and Society: A Study of the Uses of Mass Channels for Coping.

ERIC Educational Resources Information Center

Singer, Benjamin D.

This book deals with methods that individuals use to feed information and opinions back to mass communication systems. Typical examples of mass media and "information centers" were used to study feedback and environmental adjustment. Specifically, the feedback channels investigated are letters to the editor in newspapers, the urban newspaper…

Passive solar design strategies: Remodeling guidelines for conserving energy at home

NASA Astrophysics Data System (ADS)

The idea of passive solar is simple, but applying it effectively does require information and attention to the details of design and construction. Some passive solar techniques are modest and low-cost, and require only small changes in remodeler's typical practice. At the other end of the spectrum, some passive solar systems can almost eliminate a house's need for purchased heating (and in some cases, cooling) energy - but probably at a relatively high first cost. In between are a broad range of energy-conserving passive solar techniques. Whether or not they are cost-effective, practical, and attractive enough to offer a market advantage to any individual remodeler depends on very specific factors such as local costs, climate, and market characteristics. Passive Solar Design Strategies: Remodeling Guidelines For Conserving Energy At Home is written to help give remodelers the information they need to make these decisions. Passive Solar Design Strategies is a package in three basic parts: the guidelines contain information about passive solar techniques and how they work, and provides specific examples of systems which will save various percentages of energy; the worksheets offer a simple, fill-in-the-blank method to pre-evaluate the performance of a specific design; and the worked example demonstrates how to complete the worksheets for a typical residence.

Cabin Atmosphere Monitoring System (CAMS), pre-prototype model development continuation

NASA Technical Reports Server (NTRS)

Bursack, W. W.; Harris, W. A.

1975-01-01

The development of the Cabin Atmosphere Monitoring System (CAMS) is described. Attention was directed toward improving stability and reliability of the design using flight application guidelines. Considerable effort was devoted to the development of a temperature-stable RF/DC generator used for excitation of the quadrupole mass filter. Minor design changes were made in the preprototype model. Specific gas measurement examples are included along with a discussion of the measurement rationale employed.

Modeling and Simulation of Avionics Systems and Command, Control and Communications Systems

DTIC Science & Technology

1980-01-01

analytical and operational talent into a cohesive study group . This group becomes our critical mass for innovative analysis. For command and control problems...that focusing small integrated groups on specific aspects of a command and control problem sucoseds best. For example, Air Force Studies and Analyses...phase so called " study groups " should define "tactical requirement-papers", These study groups will be supported by operational analyses and by

Dynamic simulation of Static Var Compensators in distribution systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koessler, R.J.

1992-08-01

This paper is a system study guide for the correction of voltage dips due to large motor startups with Static Var Compensators (SVCs). The method utilizes time simulations, which are an important aid in the equipment design and specification. The paper illustrates the process of setting-up a computer model and performing time simulations. The study process is demonstrated through an example, the Shawnee feeder in the Niagara Mohawk Power Corporation service area.

New Space Weather Systems Under Development and Their Contribution to Space Weather Management

NASA Astrophysics Data System (ADS)

Tobiska, W.; Bouwer, D.; Schunk, R.; Garrett, H.; Mertens, C.; Bowman, B.

2008-12-01

There have been notable successes during the past decade in the development of operational space environment systems. Examples include the Magnetospheric Specification Model (MSM) of the Earth's magnetosphere, 2000; SOLAR2000 (S2K) solar spectral irradiances, 2001; High Accuracy Satellite Drag Model (HASDM) neutral atmosphere densities, 2004; Global Assimilation of Ionospheric Measurements (GAIM) ionosphere specification, 2006; Hakamada-Akasofu-Fry (HAF) solar wind parameters, 2007; Communication Alert and Prediction System (CAPS) ionosphere, high frequency radio, and scintillation S4 index prediction, 2008; and GEO Alert and Prediction System (GAPS) geosynchronous environment satellite charging specification and forecast, 2008. Operational systems that are in active operational implementation include the Jacchia-Bowman 2006/2008 (JB2006/2008) neutral atmosphere, 2009, and the Nowcast of Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) aviation radiation model using the Radiation Alert and Prediction System (RAPS), 2010. U.S. national agency and commercial assets will soon reach a state where specification and prediction will become ubiquitous and where coordinated management of the space environment and space weather will become a necessity. We describe the status of the CAPS, GAPS, RAPS, and JB2008 operational development. We additionally discuss the conditions that are laying the groundwork for space weather management and estimate the unfilled needs as we move beyond specification and prediction efforts.

The distributed annotation system.

PubMed

Dowell, R D; Jokerst, R M; Day, A; Eddy, S R; Stein, L

2001-01-01

Currently, most genome annotation is curated by centralized groups with limited resources. Efforts to share annotations transparently among multiple groups have not yet been satisfactory. Here we introduce a concept called the Distributed Annotation System (DAS). DAS allows sequence annotations to be decentralized among multiple third-party annotators and integrated on an as-needed basis by client-side software. The communication between client and servers in DAS is defined by the DAS XML specification. Annotations are displayed in layers, one per server. Any client or server adhering to the DAS XML specification can participate in the system; we describe a simple prototype client and server example. The DAS specification is being used experimentally by Ensembl, WormBase, and the Berkeley Drosophila Genome Project. Continued success will depend on the readiness of the research community to adopt DAS and provide annotations. All components are freely available from the project website http://www.biodas.org/.

Restricted Authentication and Encryption for Cyber-physical Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirkpatrick, Michael S; Bertino, Elisa; Sheldon, Frederick T

2009-01-01

Cyber-physical systems (CPS) are characterized by the close linkage of computational resources and physical devices. These systems can be deployed in a number of critical infrastructure settings. As a result, the security requirements of CPS are different than traditional computing architectures. For example, critical functions must be identified and isolated from interference by other functions. Similarly, lightweight schemes may be required, as CPS can include devices with limited computing power. One approach that offers promise for CPS security is the use of lightweight, hardware-based authentication. Specifically, we consider the use of Physically Unclonable Functions (PUFs) to bind an access requestmore » to specific hardware with device-specific keys. PUFs are implemented in hardware, such as SRAM, and can be used to uniquely identify the device. This technology could be used in CPS to ensure location-based access control and encryption, both of which would be desirable for CPS implementations.« less

Inspection system qualification and integration into the mask manufacturing environment

NASA Astrophysics Data System (ADS)

LaVoy, Rosanne; Fujioka, Ron

1995-12-01

Integration of a mask inspection system into a manufacturing environment poses new challenges to both the inspection engineer and the equipment supplier. Traditional specifications (limited primarily to sensitivity and uptime) are no longer sufficient to successfully integrate a system into a 7 by 24 manufacturing area with multiple systems. Issues such as system sensitivity matching, sensitivity characterization by defect type, operator training and certification standards, and real-time SPC control of the systems must be addressed. This paper outlines some of the techniques Intel Mask Operation uses for integration of a new inspection system into the manufacturing line. Specifically moving a beta- site type tool out of the beta-site mode and into volume production. Examples are presented, including installation for manufacturing (including ergonomic modifications), techniques for system-to-system matching, use of SPC charts to monitor system performance, and operator training/certifications. Relationships between system PMs, or other environmental changes, and the system sensitivity SPC control charts also are discussed.

Immersive virtual reality in computational chemistry: Applications to the analysis of QM and MM data.

PubMed

Salvadori, Andrea; Del Frate, Gianluca; Pagliai, Marco; Mancini, Giordano; Barone, Vincenzo

2016-11-15

The role of Virtual Reality (VR) tools in molecular sciences is analyzed in this contribution through the presentation of the Caffeine software to the quantum chemistry community. Caffeine, developed at Scuola Normale Superiore, is specifically tailored for molecular representation and data visualization with VR systems, such as VR theaters and helmets. Usefulness and advantages that can be gained by exploiting VR are here reported, considering few examples specifically selected to illustrate different level of theory and molecular representation.

Sonophoresis for Rapid Assessment of Interstitial Fluid and Drug Delivery

DTIC Science & Technology

2007-10-01

sensitive indicator of local diseases, for example skin cancer, psoriasis and eczema , but also of certain systemic diseases such as cardiovascular disease...cytokine " functionality -map" that precisely represents skin’s specific diseased milieu (Fig. 2b-CI and Fig. 3a-AD and PS, 3 additional data in. Supp...yielded a unique cytokine " functionality map", which correlates with the specific diseased state (figure 2d and 3a). A striking, rapid upregulation was

Women Working in Engineering and Science

NASA Technical Reports Server (NTRS)

Luna, Bernadette; Kliss, Mark (Technical Monitor)

1998-01-01

The presentation will focus on topics of interest to young women pursuing an engineering or scientific career, such as intrinsic personality traits of most engineers, average salaries for the various types of engineers, appropriate preparation classes at the high school and undergraduate levels, gaining experience through internships, summer jobs and graduate school, skills necessary but not always included in engineering curricula (i.e., multimedia, computer skills, communication skills), the work environment, balancing family and career, and sexual harassment. Specific examples from the speaker's own experience in NASA's Space Life Sciences Program will be used to illustrate the above topics. In particular, projects from Extravehicular Activity and Protective Systems research and Regenerative Life Support research will be used as examples of real world problem-solving to enable human exploration of the solar system.

Forecasting in the presence of expectations

NASA Astrophysics Data System (ADS)

Allen, R.; Zivin, J. G.; Shrader, J.

2016-05-01

Physical processes routinely influence economic outcomes, and actions by economic agents can, in turn, influence physical processes. This feedback creates challenges for forecasting and inference, creating the potential for complementarity between models from different academic disciplines. Using the example of prediction of water availability during a drought, we illustrate the potential biases in forecasts that only take part of a coupled system into account. In particular, we show that forecasts can alter the feedbacks between supply and demand, leading to inaccurate prediction about future states of the system. Although the example is specific to drought, the problem of feedback between expectations and forecast quality is not isolated to the particular model-it is relevant to areas as diverse as population assessments for conservation, balancing the electrical grid, and setting macroeconomic policy.

A computer-aided design system geared toward conceptual design in a research environment. [for hypersonic vehicles

NASA Technical Reports Server (NTRS)

STACK S. H.

1981-01-01

A computer-aided design system has recently been developed specifically for the small research group environment. The system is implemented on a Prime 400 minicomputer linked with a CDC 6600 computer. The goal was to assign the minicomputer specific tasks, such as data input and graphics, thereby reserving the large mainframe computer for time-consuming analysis codes. The basic structure of the design system consists of GEMPAK, a computer code that generates detailed configuration geometry from a minimum of input; interface programs that reformat GEMPAK geometry for input to the analysis codes; and utility programs that simplify computer access and data interpretation. The working system has had a large positive impact on the quantity and quality of research performed by the originating group. This paper describes the system, the major factors that contributed to its particular form, and presents examples of its application.

Toward the Design of Personalized Continuum Surgical Robots.

PubMed

Morimoto, Tania K; Greer, Joseph D; Hawkes, Elliot W; Hsieh, Michael H; Okamura, Allison M

2018-05-31

Robot-assisted minimally invasive surgical systems enable procedures with reduced pain, recovery time, and scarring compared to traditional surgery. While these improvements benefit a large number of patients, safe access to diseased sites is not always possible for specialized patient groups, including pediatric patients, due to their anatomical differences. We propose a patient-specific design paradigm that leverages the surgeon's expertise to design and fabricate robots based on preoperative medical images. The components of the patient-specific robot design process are a virtual reality design interface enabling the surgeon to design patient-specific tools, 3-D printing of these tools with a biodegradable polyester, and an actuation and control system for deployment. The designed robot is a concentric tube robot, a type of continuum robot constructed from precurved, elastic, nesting tubes. We demonstrate the overall patient-specific design workflow, from preoperative images to physical implementation, for an example clinical scenario: nonlinear renal access to a pediatric kidney. We also measure the system's behavior as it is deployed through real and artificial tissue. System integration and successful benchtop experiments in ex vivo liver and in a phantom patient model demonstrate the feasibility of using a patient-specific design workflow to plan, fabricate, and deploy personalized, flexible continuum robots.

Open Clients for Distributed Databases

NASA Astrophysics Data System (ADS)

Chayes, D. N.; Arko, R. A.

2001-12-01

We are actively developing a collection of open source example clients that demonstrate use of our "back end" data management infrastructure. The data management system is reported elsewhere at this meeting (Arko and Chayes: A Scaleable Database Infrastructure). In addition to their primary goal of being examples for others to build upon, some of these clients may have limited utility in them selves. More information about the clients and the data infrastructure is available on line at http://data.ldeo.columbia.edu. The available examples to be demonstrated include several web-based clients including those developed for the Community Review System of the Digital Library for Earth System Education, a real-time watch standers log book, an offline interface to use log book entries, a simple client to search on multibeam metadata and others are Internet enabled and generally web-based front ends that support searches against one or more relational databases using industry standard SQL queries. In addition to the web based clients, simple SQL searches from within Excel and similar applications will be demonstrated. By defining, documenting and publishing a clear interface to the fully searchable databases, it becomes relatively easy to construct client interfaces that are optimized for specific applications in comparison to building a monolithic data and user interface system.

Usability Guidelines for Product Recommenders Based on Example Critiquing Research

NASA Astrophysics Data System (ADS)

Pu, Pearl; Faltings, Boi; Chen, Li; Zhang, Jiyong; Viappiani, Paolo

Over the past decade, our group has developed a suite of decision tools based on example critiquing to help users find their preferred products in e-commerce environments. In this chapter, we survey important usability research work relative to example critiquing and summarize the major results by deriving a set of usability guidelines. Our survey is focused on three key interaction activities between the user and the system: the initial preference elicitation process, the preference revision process, and the presentation of the systems recommendation results. To provide a basis for the derivation of the guidelines, we developed a multi-objective framework of three interacting criteria: accuracy, confidence, and effort (ACE). We use this framework to analyze our past work and provide a specific context for each guideline: when the system should maximize its ability to increase users' decision accuracy, when to increase user confidence, and when to minimize the interaction effort for the users. Due to the general nature of this multi-criteria model, the set of guidelines that we propose can be used to ease the usability engineering process of other recommender systems, especially those used in e-commerce environments. The ACE framework presented here is also the first in the field to evaluate the performance of preference-based recommenders from a user-centric point of view.

The Unicellular Green Alga Chlamydomonas reinhardtii as an Experimental System to Study Chloroplast RNA Metabolism

NASA Astrophysics Data System (ADS)

Nickelsen, J.; Kück, U.

Chloroplasts are typical organelles of photoautotrophic eukaryotic cells which drive a variety of functions, including photosynthesis. For many years the unicellular green alga Chlamydomonas reinhardtii has served as an experimental organism for studying photosynthetic processes. The recent development of molecular tools for this organism together with efficient methods of genetic analysis and the availability of many photosynthesis mutants has now made this alga a powerful model system for the analysis of chloroplast biogenesis. For example, techniques have been developed to transfer recombinant DNA into both the nuclear and the chloroplast genome. This allows both complementation tests and analyses of gene functions in vivo. Moreover, site-specific DNA recombinations in the chloroplast allow targeted gene disruption experiments which enable a "reverse genetics" to be performed. The potential of the algal system for the study of chloroplast biogenesis is illustrated in this review by the description of regulatory systems of gene expression involved in organelle biogenesis. One example concerns the regulation of trans-splicing of chloroplast mRNAs, a process which is controlled by both multiple nuclear- and chloroplast-encoded factors. The second example involves the stabilization of chloroplast mRNAs. The available data lead us predict distinct RNA elements, which interact with trans-acting factors to protect the RNA against nucleolytic attacks.

Index of cyber integrity

NASA Astrophysics Data System (ADS)

Anderson, Gustave

2014-05-01

Unfortunately, there is no metric, nor set of metrics, that are both general enough to encompass all possible types of applications yet specific enough to capture the application and attack specific details. As a result we are left with ad-hoc methods for generating evaluations of the security of our systems. Current state of the art methods for evaluating the security of systems include penetration testing and cyber evaluation tests. For these evaluations, security professionals simulate an attack from malicious outsiders and malicious insiders. These evaluations are very productive and are able to discover potential vulnerabilities resulting from improper system configuration, hardware and software flaws, or operational weaknesses. We therefore propose the index of cyber integrity (ICI), which is modeled after the index of biological integrity (IBI) to provide a holistic measure of the health of a system under test in a cyber-environment. The ICI provides a broad base measure through a collection of application and system specific metrics. In this paper, following the example of the IBI, we demonstrate how a multi-metric index may be used as a holistic measure of the health of a system under test in a cyber-environment.

Network placement optimization for large-scale distributed system

NASA Astrophysics Data System (ADS)

Ren, Yu; Liu, Fangfang; Fu, Yunxia; Zhou, Zheng

2018-01-01

The network geometry strongly influences the performance of the distributed system, i.e., the coverage capability, measurement accuracy and overall cost. Therefore the network placement optimization represents an urgent issue in the distributed measurement, even in large-scale metrology. This paper presents an effective computer-assisted network placement optimization procedure for the large-scale distributed system and illustrates it with the example of the multi-tracker system. To get an optimal placement, the coverage capability and the coordinate uncertainty of the network are quantified. Then a placement optimization objective function is developed in terms of coverage capabilities, measurement accuracy and overall cost. And a novel grid-based encoding approach for Genetic algorithm is proposed. So the network placement is optimized by a global rough search and a local detailed search. Its obvious advantage is that there is no need for a specific initial placement. At last, a specific application illustrates this placement optimization procedure can simulate the measurement results of a specific network and design the optimal placement efficiently.

The first teleautomatic low-voltage prosthesis with multiple therapeutic applications: a new version of the German artificial sphincter system.

PubMed

Ruthmann, Olaf; Richter, Sabine; Seifert, Gabriel; Karcz, Wojciech; Goldschmidboing, Frank; Lemke, Thomas; Biancuzzi, Gionvanni; Woias, Peter; Schmidt, Thomas; Schwarzbqch, Stefan; Vodermayer, Bernahard; Hopt, Ulrich; Schrag, Hans-Jurgen

2010-08-01

To date, there are no artificial sphincter prostheses for urinary or fecal incontinence that may be implemented elsewhere instead, for example, in the upper gastrointestinal tract. Conventional systems are conceptually similar but are constructed specifically for distinct applications and are manual in operation. The German Artificial Sphincter System (GASS) II is the evolution of a highly integrative, modular, telemetric sphincter prosthesis with more than one application. Redesigning and integrating multilayer actuators into the pump allows us to reduce the input voltage to -10 to +20 V (V(PP) = 30 V). This provides for a flow rate of 2.23 mL/min and a counterpressure stability of 260 mbar. Furthermore, multiple applications have become feasible due to our standardized connection system, therapy-specific compression units, and application-specific software. These innovations allow us to integrate not only severe fecal and urinary incontinence, erectile dysfunction, and therapy-resistant reflux disease, but also morbid adiposity into the gamut of therapeutic GASS applications.

Physiological effects of toxic substances on wildlife species

USGS Publications Warehouse

Haseltine, S.D.; Kacmar, Peter; Legath, J.

1983-01-01

Study of the physiological effects of contaminants on wildlife species has expanded as more sophisticated medical techniques are adapted to wildlife and as the mode of action of new classes of pesticides increase the number of organ systems which may be sublethally or lethally impacted. This paper summarizes some of the latest data published on toxicant affects on organ systems of warm-blooded vertebrates. Reporting on effects with enzyme systems concentrates on cholinesterase in blood and plasma after sublethal and lethal exposure to organophosphate end carbamate pesticides, but also covers, recent work with Na+, k+-ATPases, AST, AAT, and AL.AD. A discussion of recent work on hormones, biogenlc amines, and other compounds which indicate alteration of specific organ systems, is followed by examples of histopathological lesions associated both pathognomically and non-specifically with widely-used and/or severely toxic contaminants. All these specific effects and lesions are then discussed in terms of their potential for use diagnostically in field problems and their practical and possible impact on wildlife populations.

Selecting habitat management strategies on refuges

USGS Publications Warehouse

Schroeder, Richard L.; King, Wayne J.; Cornely, John E.

1998-01-01

This report is a joint effort of the Biological Resources Division, U.S. Geological Survey and the U.S. Fish and Wildlife Service (FWS) to provide National Wildlife Refuge (NWR) managers guidance on the selection and evaluation of habitat management strategies to meet stated objectives. The FWS recently completed a handbook on writing refuge management goals and objectives (U.S. Fish and Wildlife Service 1996a). the National Wildlife Refuge System Improvement Act of 1997 requires that National Wildlife Refuge System (NWRS) lands be managed according to approved Comprehensive Conservation Plans to guide management decisions and devise strategies for achieving refuge unit purposes and meeting the NWRS mission. It is expected that over the next several years most refuges will develop new or revised refuge goals and objectives for directing their habitat management strategies. This paper outlines the steps we recommend in selecting and evaluating habitat management strategies to meet specific refuge habitat objectives. We selected two examples to illustrate the process. Although each refuge is unique and will require specific information and solutions, these two examples can be used as guidance when selecting and evaluating habitat management strategies for other refuge resources: Example 1. Management of floodplain woods habitat for forest interior birds. The biological recourse of concern is the quality and quantity of floodplain woods habitat for eastern forest interior birds in the Cypress Creek NWR (U.S. Fish and Wildlife Service 1996b). Example 2. Management of habitat for biodiversity: Historical landscape proportions. The biological resource of concern is the change in diversity associated with man-induced changes in the distribution and abundance of habitat types at the Minnesota Valley NWR (U.S. Fish and Wildlife Service 1996c).

Neuroinvasion and Inflammation in Viral Central Nervous System Infections

PubMed Central

Schroten, Horst

2016-01-01

Neurotropic viruses can cause devastating central nervous system (CNS) infections, especially in young children and the elderly. The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) have been described as relevant sites of entry for specific viruses as well as for leukocytes, which are recruited during the proinflammatory response in the course of CNS infection. In this review, we illustrate examples of established brain barrier models, in which the specific reaction patterns of different viral families can be analyzed. Furthermore, we highlight the pathogen specific array of cytokines and chemokines involved in immunological responses in viral CNS infections. We discuss in detail the link between specific cytokines and chemokines and leukocyte migration profiles. The thorough understanding of the complex and interrelated inflammatory mechanisms as well as identifying universal mediators promoting CNS inflammation is essential for the development of new diagnostic and treatment strategies. PMID:27313404

A microRNA-initiated DNAzyme motor operating in living cells

NASA Astrophysics Data System (ADS)

Peng, Hanyong; Li, Xing-Fang; Zhang, Hongquan; Le, X. Chris

2017-03-01

Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP. An example DNAzyme motor responsive to a specific microRNA enables amplified detection of the specific microRNA in individual cancer cells. Activated by specific intracellular targets, these self-powered DNAzyme motors will have diverse applications in the control and modulation of biological functions.

Historical Trends in Ground-Based Optical Space Surveillance System Design

NASA Astrophysics Data System (ADS)

Shoemaker, M.; Shroyer, L.

In the spirit of the 50th anniversary of the launch of the first man-made satellite, an historical overview of ground-based optical space surveillance systems is provided. Specific emphasis is given on gathering metrics to analyze design trends. The subject of space surveillance spans the history of spaceflight: from the early tracking cameras at missile ranges, the first observations of Sputnik, to the evolution towards highly capable commercial off-the-shelf (COTS) systems, and much in between. Whereas previous reviews in the literature have been limited in scope to specific time periods, operational programs, countries, etc., a broad overview of a wide range of sources is presented. This review is focused on systems whose primary design purpose can be classified as Space Object Identification (SOI) or Orbit Determination (OD). SOI systems are those that capture images or data to determine information about the satellite itself, such as attitude, features, and material composition. OD systems are those that produce estimates of the satellite position, usually in the form of orbital elements or a time history of tracking angles. Systems are also categorized based on the orbital regime in which their targets reside, which has been simplified in this study to either Low Earth Orbit (LEO) or Geosynchronous Earth Orbit (GEO). The systems are further classified depending on the industry segment (government/commercial or academic), and whether the program is foreign or domestic. In addition to gathering metrics on systems designed solely for man-made satellite observations, it is interesting to find examples of other systems being similarly used. Examples include large astronomical telescopes being used for GEO debris surveys and anomaly resolution for deep-space probes. Another interesting development is the increase in number and capability of COTS systems, some of which are specifically marketed to consumers as satellite trackers. After describing the results of the literature review and presenting further information on various systems, we gather specific metrics on the optical design. Technical specifications, such as aperture and field of view (FOV), are plotted with time to ascertain trends in ground system design. Aperture is a useful metric because it gives insight into the light-gathering capability, as well as the overall size and complexity of the system. The size of the FOV can indicate user priorities or system performance, such as tracking capability of the mount for SOI systems and star detection ability in OD systems that use celestial references for position measurements. The review is restricted to systems that use natural sunlight to illuminate targets, for the simple reason of having commonality between systems that span half a century, particularly recent COTS systems.

Physical and Chemical Toeholds for Exoplanet Bioastronomy

NASA Technical Reports Server (NTRS)

Hoehler, Tori

2013-01-01

If a search for exoplanet life were mounted today, the likely focus would be to detect oxygen (or ozone) in the atmosphere of a water-bearing rocky planet orbiting roughly 1AU from a G-type star. This appropriately conservative and practical default is necessary in large part because biological input on the question of where and how to look for life has progressed little beyond a purely empirical reliance on the example of terrestrial biology. However, fundamental physical and chemical considerations may impose significant yet universal constraints on biological potential. The liquid water + oxygen paradigm will be considered as an example, with a focus on the question, is liquid water a prerequisite for life? . Life requires a solvent to mediate interactions among biological molecules. A key class of these interactions is molecular recognition with high specificity, which is essential for high fidelity catalysis and (especially) information processing. For example, to correctly reproduce a string consisting of 600,000 units of information (e.g., 600 kilobases, equivalent to the genome of the smallest free living terrestrial organisms) with a 90% success rate requires specificity greater than 10(exp 7):1 for the target molecule vs. incorrect alternatives. Such specificity requires (i) that the correct molecular association is energetically stabilized by at least 40 kJ/mol relative to alternatives, and (ii) that the system is able to sample among possible states (alternative molecular associations) rapidly enough to allow the system to fall under thermodynamic control and express the energetic stabilization. We argue that electrostatic interactions are required to confer the necessary energetic stabilization vs. a large library of molecular alternatives, and that a solvent with polarity and dielectric properties comparable to water is required for the system to sample among possible states and express thermodynamic control. Electrostatic associations can be made in non-polar solvents, but the resulting complexes are too stable to be "unmade" with sufficient frequency to confer thermodynamic control on the system. Such considerations suggest that water, or a solvent with properties very like water, is necessary to support high-fidelity information processing a feature that must be common to all biology and can therefore be considered a critical prerequisite for life.

Integrated Multidisciplinary Optimization Objects

NASA Technical Reports Server (NTRS)

Alston, Katherine

2014-01-01

OpenMDAO is an open-source MDAO framework. It is used to develop an integrated analysis and design environment for engineering challenges. This Phase II project integrated additional modules and design tools into OpenMDAO to perform discipline-specific analysis across multiple flight regimes at varying levels of fidelity. It also showcased a refined system architecture that allows the system to be less customized to a specific configuration (i.e., system and configuration separation). By delivering a capable and validated MDAO system along with a set of example applications to be used as a template for future users, this work greatly expands NASA's high-fidelity, physics-based MDAO capabilities and enables the design of revolutionary vehicles in a cost-effective manner. This proposed work complements M4 Engineering's expertise in developing modeling and simulation toolsets that solve relevant subsonic, supersonic, and hypersonic demonstration applications.

Natural evolution, disease, and localization in the immune system

NASA Astrophysics Data System (ADS)

Deem, Michael

2004-03-01

Adaptive vertebrate immune system is a wonder of modern evolution. Under most circumstances, the dynamics of the immune system is well-matched to the dynamics of pathogen growth during a typical infection. Some pathogens, however, have evolved escape mechanisms that interact in subtle ways with the immune system dynamics. In addition, negative interactions the immune system, which has evolved over 400 000 000 years, and vaccination,which has been practiced for only 200 years, are possible. For example,vaccination against the flu can actually increase susceptibility to the flu in the next year. As another example, vaccination against one of the four strains of dengue fever typically increases susceptibility against the other three strains. Immunodominance also arises in the immune system control of nascent tumors--the immune system recognizes only a small subset of the tumor specific antigens, and the rest are free to grow and cause tumor growth. In this talk, I present a physical theory of original antigenic sin and immunodominance. How localization in the immune system leads to the observed phenomena is discussed. 1) M. W. Deem and H. Y. Lee, ``Sequence Space Localization in the Immune System Response to Vaccination and Disease,'' Phys. Rev. Lett. 91 (2003) 068101

Intelligent tutoring systems for space applications

NASA Technical Reports Server (NTRS)

Luckhardt-Redfield, Carol A.

1990-01-01

Artificial Intelligence has been used in many space applications. Intelligent tutoring systems (ITSs) have only recently been developed for assisting training of space operations and skills. An ITS at Southwest Research Institute is described as an example of an ITS application for space operations, specifically, training console operations at mission control. A distinction is made between critical skills and knowledge versus routine skills. Other ITSs for space are also discussed and future training requirements and potential ITS solutions are described.

Human Factors Workshop on Aviation (4th) Transcript Held at Atlantic City, New Jersey on 13-15 May 1981.

DTIC Science & Technology

1982-05-01

and some specific examples of problems and recom- mended solutions . At the third workshop, we continued the process of defining and discussing the... procurement . The replacement of computer and display equipment in a system that must * support continuous operation without degradation in service...all facilities are equally busy . We have also been running, with the assistance of our Transportation Systems Center and the MITRE Corporation, a

Enabling Dynamic Security Management of Networked Systems via Device-Embedded Security (Self-Securing Devices)

DTIC Science & Technology

2007-01-15

it can detect specifically proscribed content changes to critical files (e.g., illegal shells inserted into /etc/ passwd ). Fourth, it can detect the...UNIX password management involves a pair of inter-related files (/etc/ passwd and /etc/shadow). The corresponding access patterns seen at the storage...content integrity verification is utilized. As a concrete example, consider a UNIX system password file (/etc/ passwd ), which consists of a set of well

Teleconferencing in Wisconsin

NASA Technical Reports Server (NTRS)

Lawson, R. G.

1971-01-01

The use of satellite communications capabilities for conducting conferences at various locations with maximum participation of the persons attending the conference is discussed. Specific examples of the use of this capability in the operation of conferences conducted by the University of Wisconsin are presented. The two aspects of the the system, telelectures with no feedback and teleconferences with feedback are considered.

Teaching Higher Order Thinking in the Introductory MIS Course: A Model-Directed Approach

ERIC Educational Resources Information Center

Wang, Shouhong; Wang, Hai

2011-01-01

One vision of education evolution is to change the modes of thinking of students. Critical thinking, design thinking, and system thinking are higher order thinking paradigms that are specifically pertinent to business education. A model-directed approach to teaching and learning higher order thinking is proposed. An example of application of the…

40 CFR 1048.205 - What must I include in my application?

Code of Federal Regulations, 2011 CFR

2011-07-01

... (AECDs) and all fuel-system components you will install on any production or test engine. Identify the... fuel types on which your engines are designed to operate (for example, gasoline and natural gas). List... maintenance you did. (g) List the specifications of each test fuel to show that it falls within the required...

40 CFR 1048.205 - What must I include in my application?

Code of Federal Regulations, 2012 CFR

2012-07-01

... (AECDs) and all fuel-system components you will install on any production or test engine. Identify the... fuel types on which your engines are designed to operate (for example, gasoline and natural gas). List... maintenance you did. (g) List the specifications of each test fuel to show that it falls within the required...

Syntheses of the current model applications for managing water and needs for experimental data and model improvements to enhance these applications

USDA-ARS?s Scientific Manuscript database

This volume of the Advances in Agricultural Systems Modeling series presents 14 different case studies of model applications to help make the best use of limited water in agriculture. These examples show that models have tremendous potential and value in enhancing site-specific water management for ...

On Using GIS to Teach in the Social Sciences

ERIC Educational Resources Information Center

Harris, Jill S.

2012-01-01

In this article, the author discusses how a professor can harness the power of Geographic Information Systems (GIS) and use GIS to teach in the social sciences. She shows examples of how GIS can illustrate concepts during lecture or discussion, and provides two specific GIS assignments: one for undergraduate students and the other for graduate…

CoSN K12 Open Technologies Implementation Study #3. Moodle: An Open Learning Content Management System for Schools

ERIC Educational Resources Information Center

Consortium for School Networking (NJ1), 2008

2008-01-01

This report introduces educators to Moodle, an open-source software program for managing courses online. It briefly defines what Moodle is, what it can do, and gives specific examples of how it is being implemented. An appendix contains brief profiles of five school organizations that are using Moodle.

Assessment for Equity and Inclusion. Embracing All Our Children. Transforming Teaching Series.

ERIC Educational Resources Information Center

Goodwin, A. Lin, Ed.

The chapters in this collection explore alternative assessment and give specific examples of successful efforts by teachers to develop their own systems of assessment. Taken together, these chapters are a rejection of the ranking and separating of students according to test scores, and an argument for richer forms of mixed alternative assessments.…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Avetissian, H. K.; Avchyan, B. R.; Mkrtchian, G. F.

The multiphoton resonant excitation of three-level atoms by the two laser fields of different frequencies is investigated. The time evolution of the system and analytical solutions expressing Rabi oscillations of the probability amplitudes at the two-color multiphoton resonant excitation are found using a nonperturbative resonant approach. The specific examples for experimental implementation of two-color multiphoton resonant excitation of hydrogen atoms are considered.

Simulation as a Teaching Technology: A Brief History of Its Use in Nursing Education

ERIC Educational Resources Information Center

Sanko, Jill S.

2017-01-01

Simulation can be used for teaching or practicing both technical skills (insertion of intravenous catheters, or suturing for example) and non-technical skills (communication and teamwork). A combination of full body, high and low technology simulators (mannequins designed to depict humans), body part or body system-specific task trainers (models…

A Simple Example of an SADMT (SDI-Strategic Defense Initiative) Architecture Dataflow Modeling Technique) Architecture Specification. Version 1.5.

DTIC Science & Technology

1988-04-21

Layton Senior Software Engineer Martin Marietta Denver Aerospace MS L0425 P.O. Box 179 Denver, CO 80201 Larry L. Lehman Integrated Systems Inc. 2500...Mission College Road Santa Clara, CA 95054 Eric Leighninger Dynamics Research 60 Frontage Road Andover, MA 01810 . Peter Lempp Software Products and

Methodology for the systems engineering process. Volume 3: Operational availability

NASA Technical Reports Server (NTRS)

Nelson, J. H.

1972-01-01

A detailed description and explanation of the operational availability parameter is presented. The fundamental mathematical basis for operational availability is developed, and its relationship to a system's overall performance effectiveness is illustrated within the context of identifying specific availability requirements. Thus, in attempting to provide a general methodology for treating both hypothetical and existing availability requirements, the concept of an availability state, in conjunction with the more conventional probability-time capability, is investigated. In this respect, emphasis is focused upon a balanced analytical and pragmatic treatment of operational availability within the system design process. For example, several applications of operational availability to typical aerospace systems are presented, encompassing the techniques of Monte Carlo simulation, system performance availability trade-off studies, analytical modeling of specific scenarios, as well as the determination of launch-on-time probabilities. Finally, an extensive bibliography is provided to indicate further levels of depth and detail of the operational availability parameter.

Property Specification Patterns for intelligence building software

NASA Astrophysics Data System (ADS)

Chun, Seungsu

2018-03-01

In this paper, through the property specification pattern research for Modal MU(μ) logical aspects present a single framework based on the pattern of intelligence building software. In this study, broken down by state property specification pattern classification of Dwyer (S) and action (A) and was subdivided into it again strong (A) and weaknesses (E). Through these means based on a hierarchical pattern classification of the property specification pattern analysis of logical aspects Mu(μ) was applied to the pattern classification of the examples used in the actual model checker. As a result, not only can a more accurate classification than the existing classification systems were easy to create and understand the attributes specified.

Automated software development workstation

NASA Technical Reports Server (NTRS)

1986-01-01

Engineering software development was automated using an expert system (rule-based) approach. The use of this technology offers benefits not available from current software development and maintenance methodologies. A workstation was built with a library or program data base with methods for browsing the designs stored; a system for graphical specification of designs including a capability for hierarchical refinement and definition in a graphical design system; and an automated code generation capability in FORTRAN. The workstation was then used in a demonstration with examples from an attitude control subsystem design for the space station. Documentation and recommendations are presented.

Methods for increasing noise immunity of radio electronic systems with redundancy

NASA Astrophysics Data System (ADS)

Orlov, P. E.; Medvedev, A. V.; Sharafutdinov, V. R.; Gazizov, T. R.; Ubaichin, A. V.

2018-05-01

The idea of increasing the noise immunity of radioelectronic systems with redundancy is presented. Specific technical solutions based on this idea of modal redundancy are described. An estimation of noise immunity improvement was performed by the example of implementation of modal redundancy with the broad-side electromagnetic coupling for a printed circuit board of the digital signal processing unit for an autonomous navigation system of a spacecraft. It is shown that the implementation of modal redundancy can provide an attenuation coefficient for the interference signal up to 12 dB.

Computer-Aided Modeling and Analysis of Power Processing Systems (CAMAPPS). Phase 1: Users handbook

NASA Technical Reports Server (NTRS)

Kim, S.; Lee, J.; Cho, B. H.; Lee, F. C.

1986-01-01

The EASY5 macro component models developed for the spacecraft power system simulation are described. A brief explanation about how to use the macro components with the EASY5 Standard Components to build a specific system is given through an example. The macro components are ordered according to the following functional group: converter power stage models, compensator models, current-feedback models, constant frequency control models, load models, solar array models, and shunt regulator models. Major equations, a circuit model, and a program listing are provided for each macro component.

Basic methods for measuring the reflectance color of iron oxides

NASA Astrophysics Data System (ADS)

Pospisil, Jaroslav; Hrdy, Jan; Hrdy Jan, Jr.

2007-06-01

The main contribution of the present article consists in coherent description and interpretation of the principles of basic measuring methods and colorimeters for color classification and evaluation of light reflecting samples containing iron oxides. The chosen relevant theoretical background is based on the CIE tristimulus colorimetric system (X,Y,Z), the CIE colorimetric system (L*,a*,b*) and the Munsell colorimetric system (H,V,C). As an example of color identification and evaluation, some specific mathematical and graphical relationships between the soil redness rate and the corresponding hematite content are shown.

Model-Based Verification and Validation of the SMAP Uplink Processes

NASA Technical Reports Server (NTRS)

Khan, M. Omair; Dubos, Gregory F.; Tirona, Joseph; Standley, Shaun

2013-01-01

This case study stands as an example of how a project can validate a system-level design earlier in the project life cycle than traditional V&V processes by using simulation on a system model. Specifically, this paper describes how simulation was added to a system model of the Soil Moisture Active-Passive (SMAP) mission's uplink process.Also discussed are the advantages and disadvantages of the methods employed and the lessons learned; which are intended to benefit future model-based and simulation-based V&V development efforts.

Drug delivery systems with modified release for systemic and biophase bioavailability.

PubMed

Leucuta, Sorin E

2012-11-01

This review describes the most important new generations of pharmaceutical systems: medicines with extended release, controlled release pharmaceutical systems, pharmaceutical systems for the targeted delivery of drug substances. The latest advances and approaches for delivering small molecular weight drugs and other biologically active agents such as proteins and nucleic acids require novel delivery technologies, the success of a drug being many times dependent on the delivery method. All these dosage forms are qualitatively superior to medicines with immediate release, in that they ensure optimal drug concentrations depending on specific demands of different disease particularities of the body. Drug delivery of these pharmaceutical formulations has the benefit of improving product efficacy and safety, as well as patient convenience and compliance. This paper describes the biopharmaceutical, pharmacokinetic, pharmacologic and technological principles in the design of drug delivery systems with modified release as well as the formulation criteria of prolonged and controlled release drug delivery systems. The paper presents pharmaceutical prolonged and controlled release dosage forms intended for different routes of administration: oral, ocular, transdermal, parenteral, pulmonary, mucoadhesive, but also orally fast dissolving tablets, gastroretentive drug delivery systems, colon-specific drug delivery systems, pulsatile drug delivery systems and carrier or ligand mediated transport for site specific or receptor drug targeting. Specific technologies are given on the dosage forms with modified release as well as examples of marketed products, and current research in these areas.

The neurology of poverty.

PubMed

Alvarez, G

1982-01-01

An intellectual deficit is known to exist in populations where extreme poverty is rife and is thus seen extensively in the lower socio-economic strata of underdeveloped nations. Poverty is a complex entity whose sociological and economic indicators often bear little relevance to the biological agents which can affect the central nervous system. An attempt is made to express poverty in terms of identifiable defects, physiological in nature. Thus adverse socio-economic factors are converted into specific biological entities which, though necessary for adequate development of the brain, are restricted where there is poverty. A number of causative deficiencies, including nutritional, visual, auditory, tactile, vestibular, affective, and other stimuli are postulated. These interact and potentiate one another. Each is capable of an independent action on the brain and examples are given of some sensory deprivations as well as malnutrition and their possible mechanism of action. If the various deficiencies can independently harm the brain, then a number of separate specific functions should be affected; examples are offered. The nature of this intellectual deficit is probably a non-fulfillment of genetic potential of certain specific functions of the brain, which may exhibit limited variations between one community and another, depending on cultural differences. The deleterious effect of this intellectual impairment is seen most clearly in figures of school desertion, for example in Latin America. Analogous data for adults is scarce.

Methods and application of system identification in shock and vibration.

NASA Technical Reports Server (NTRS)

Collins, J. D.; Young, J. P.; Kiefling, L.

1972-01-01

A logical picture is presented of current useful system identification techniques in the shock and vibration field. A technology tree diagram is developed for the purpose of organizing and categorizing the widely varying approaches according to the fundamental nature of each. Specific examples of accomplished activity for each identification category are noted and discussed. To provide greater insight into the most current trends in the system identification field, a somewhat detailed description is presented of the essential features of a recently developed technique that is based on making the maximum use of all statistically known information about a system.

Efficient evaluation of wireless real-time control networks.

PubMed

Horvath, Peter; Yampolskiy, Mark; Koutsoukos, Xenofon

2015-02-11

In this paper, we present a system simulation framework for the design and performance evaluation of complex wireless cyber-physical systems. We describe the simulator architecture and the specific developments that are required to simulate cyber-physical systems relying on multi-channel, multihop mesh networks. We introduce realistic and efficient physical layer models and a system simulation methodology, which provides statistically significant performance evaluation results with low computational complexity. The capabilities of the proposed framework are illustrated in the example of WirelessHART, a centralized, real-time, multi-hop mesh network designed for industrial control and monitor applications.

Thermodynamic laws in isolated systems.

PubMed

Hilbert, Stefan; Hänggi, Peter; Dunkel, Jörn

2014-12-01

The recent experimental realization of exotic matter states in isolated quantum systems and the ensuing controversy about the existence of negative absolute temperatures demand a careful analysis of the conceptual foundations underlying microcanonical thermostatistics. Here we provide a detailed comparison of the most commonly considered microcanonical entropy definitions, focusing specifically on whether they satisfy or violate the zeroth, first, and second laws of thermodynamics. Our analysis shows that, for a broad class of systems that includes all standard classical Hamiltonian systems, only the Gibbs volume entropy fulfills all three laws simultaneously. To avoid ambiguities, the discussion is restricted to exact results and analytically tractable examples.

Integrating Top-down and Bottom-up Cybersecurity Guidance using XML

PubMed Central

Lubell, Joshua

2016-01-01

This paper describes a markup-based approach for synthesizing disparate information sources and discusses a software implementation of the approach. The implementation makes it easier for people to use two complementary, but differently structured, guidance specifications together: the (top-down) Cybersecurity Framework and the (bottom-up) National Institute of Standards and Technology Special Publication 800-53 security control catalog. An example scenario demonstrates how the software implementation can help a security professional select the appropriate safeguards for restricting unauthorized access to an Industrial Control System. The implementation and example show the benefits of this approach and suggest its potential application to disciplines other than cybersecurity. PMID:27795810

Schedule-Aware Workflow Management Systems

NASA Astrophysics Data System (ADS)

Mans, Ronny S.; Russell, Nick C.; van der Aalst, Wil M. P.; Moleman, Arnold J.; Bakker, Piet J. M.

Contemporary workflow management systems offer work-items to users through specific work-lists. Users select the work-items they will perform without having a specific schedule in mind. However, in many environments work needs to be scheduled and performed at particular times. For example, in hospitals many work-items are linked to appointments, e.g., a doctor cannot perform surgery without reserving an operating theater and making sure that the patient is present. One of the problems when applying workflow technology in such domains is the lack of calendar-based scheduling support. In this paper, we present an approach that supports the seamless integration of unscheduled (flow) and scheduled (schedule) tasks. Using CPN Tools we have developed a specification and simulation model for schedule-aware workflow management systems. Based on this a system has been realized that uses YAWL, Microsoft Exchange Server 2007, Outlook, and a dedicated scheduling service. The approach is illustrated using a real-life case study at the AMC hospital in the Netherlands. In addition, we elaborate on the experiences obtained when developing and implementing a system of this scale using formal techniques.

Classification of Blood-Group Antibodies as β2M or γ Globulin

PubMed Central

Adinolfi, M.; Polley, Margaret J.; Hunter, Denise A.; Mollison, P. L.

1962-01-01

Thirty selected blood-group antibodies (excluding anti-A and anti-B) have been classified as β2M (19S γ) globulin, γ (7S γ) globulin or mixtures, using the following three methods: fractionation on a DEAE-cellulose column; indirect anti-globulin tests, using specific anti-β2M-globulin and anti-γ-globulin sera; and treatment with 2-mercapto-ethanol. With only minor exceptions, results obtained with the three methods were in agreement. Most blood-group antibodies within the Le, MNSs and P systems appear to be `naturally occurring' and these were found to be β2M globulin. Blood-group antibodies within the Rh, K and Jk systems, which had arisen after an antigenic stimulus, were usually γ globulin but were occasionally β2M globulin. Antibodies composed of β2M globulin usually behave as agglutinins but may behave as incomplete antibodies (e.g. some examples of anti-Jka); conversely, antibodies composed of γ globulin usually behave as incomplete antibodies but may behave as agglutinins (e.g. an example of anti-M). The ability to bind complement seems to be related more to the blood-group specificity of the particular antibody than to its molecular size. For example, anti-Jka, when composed either of γ or β2M globulin, seems invariably to bind complement, whereas potent anti-M or anti-Rh, whether composed of γ or β2M globulin, do not bind complement. PMID:14011076

Robust set-point regulation for ecological models with multiple management goals.

PubMed

Guiver, Chris; Mueller, Markus; Hodgson, Dave; Townley, Stuart

2016-05-01

Population managers will often have to deal with problems of meeting multiple goals, for example, keeping at specific levels both the total population and population abundances in given stage-classes of a stratified population. In control engineering, such set-point regulation problems are commonly tackled using multi-input, multi-output proportional and integral (PI) feedback controllers. Building on our recent results for population management with single goals, we develop a PI control approach in a context of multi-objective population management. We show that robust set-point regulation is achieved by using a modified PI controller with saturation and anti-windup elements, both described in the paper, and illustrate the theory with examples. Our results apply more generally to linear control systems with positive state variables, including a class of infinite-dimensional systems, and thus have broader appeal.

On the Path to SunShot - The Role of Advancements in Solar Photovoltaic Efficiency, Reliability, and Costs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woodhouse, Michael; Jones-Albertus, Rebecca; Feldman, David

2016-05-01

Although tremendous progress has been made in reducing the cost of PV systems, additional LCOE reductions of 40%–50% between 2015 and 2020 will be required to reach the SunShot Initiative’s targets (see Woodhouse et al. 2016). Understanding the tradeoffs between installed prices and other PV system characteristics—such as module efficiency, module degradation rate, and system lifetime—are vital. For example, with 29%-efficient modules and high reliability (a 50-year lifetime and a 0.2%/year module degradation rate), a residential PV system could achieve the SunShot LCOE goal with modules priced at almost $1.20/W. But change the lifetime to 10 years and the degradationmore » rate to 2%/year, and the system would need those very high-efficiency modules at zero cost to achieve the same LCOE. Although these examples are extreme, they serve to illustrate the wide range of technological combinations that could help drive PV toward the LCOE goals. SunShot’s PV roadmaps illustrate specific potential pathways to the target cost reductions.« less

Quantitative knowledge acquisition for expert systems

NASA Technical Reports Server (NTRS)

Belkin, Brenda L.; Stengel, Robert F.

1991-01-01

A common problem in the design of expert systems is the definition of rules from data obtained in system operation or simulation. While it is relatively easy to collect data and to log the comments of human operators engaged in experiments, generalizing such information to a set of rules has not previously been a direct task. A statistical method is presented for generating rule bases from numerical data, motivated by an example based on aircraft navigation with multiple sensors. The specific objective is to design an expert system that selects a satisfactory suite of measurements from a dissimilar, redundant set, given an arbitrary navigation geometry and possible sensor failures. The systematic development is described of a Navigation Sensor Management (NSM) Expert System from Kalman Filter convariance data. The method invokes two statistical techniques: Analysis of Variance (ANOVA) and the ID3 Algorithm. The ANOVA technique indicates whether variations of problem parameters give statistically different covariance results, and the ID3 algorithms identifies the relationships between the problem parameters using probabilistic knowledge extracted from a simulation example set. Both are detailed.

Adapting forest health assessments to changing perspectives on threats--a case example from Sweden.

PubMed

Wulff, Sören; Lindelöw, Åke; Lundin, Lars; Hansson, Per; Axelsson, Anna-Lena; Barklund, Pia; Wijk, Sture; Ståhl, Göran

2012-04-01

A revised Swedish forest health assessment system is presented. The assessment system is composed of several interacting components which target information needs for strategic and operational decision making and accommodate a continuously expanding knowledge base. The main motivation for separating information for strategic and operational decision making is that major damage outbreaks are often scattered throughout the landscape. Generally, large-scale inventories (such as national forest inventories) cannot provide adequate information for mitigation measures. In addition to broad monitoring programs that provide time-series information on known damaging agents and their effects, there is also a need for local and regional inventories adapted to specific damage events. While information for decision making is the major focus of the health assessment system, the system also contributes to expanding the knowledge base of forest conditions. For example, the integrated monitoring programs provide a better understanding of ecological processes linked to forest health. The new health assessment system should be able to respond to the need for quick and reliable information and thus will be an important part of the future monitoring of Swedish forests.

High dimensional feature reduction via projection pursuit

NASA Technical Reports Server (NTRS)

Jimenez, Luis; Landgrebe, David

1994-01-01

The recent development of more sophisticated remote sensing systems enables the measurement of radiation in many more spectral intervals than previously possible. An example of that technology is the AVIRIS system, which collects image data in 220 bands. As a result of this, new algorithms must be developed in order to analyze the more complex data effectively. Data in a high dimensional space presents a substantial challenge, since intuitive concepts valid in a 2-3 dimensional space to not necessarily apply in higher dimensional spaces. For example, high dimensional space is mostly empty. This results from the concentration of data in the corners of hypercubes. Other examples may be cited. Such observations suggest the need to project data to a subspace of a much lower dimension on a problem specific basis in such a manner that information is not lost. Projection Pursuit is a technique that will accomplish such a goal. Since it processes data in lower dimensions, it should avoid many of the difficulties of high dimensional spaces. In this paper, we begin the investigation of some of the properties of Projection Pursuit for this purpose.

Finding Feasible Abstract Counter-Examples

NASA Technical Reports Server (NTRS)

Pasareanu, Corina S.; Dwyer, Matthew B.; Visser, Willem; Clancy, Daniel (Technical Monitor)

2002-01-01

A strength of model checking is its ability to automate the detection of subtle system errors and produce traces that exhibit those errors. Given the high computational cost of model checking most researchers advocate the use of aggressive property-preserving abstractions. Unfortunately, the more aggressively a system is abstracted the more infeasible behavior it will have. Thus, while abstraction enables efficient model checking it also threatens the usefulness of model checking as a defect detection tool, since it may be difficult to determine whether a counter-example is feasible and hence worth developer time to analyze. We have explored several strategies for addressing this problem by extending an explicit-state model checker, Java PathFinder (JPF), to search for and analyze counter-examples in the presence of abstractions. We demonstrate that these techniques effectively preserve the defect detection ability of model checking in the presence of aggressive abstraction by applying them to check properties of several abstracted multi-threaded Java programs. These new capabilities are not specific to JPF and can be easily adapted to other model checking frameworks; we describe how this was done for the Bandera toolset.

Biomarkers of response and resistance to antiangiogenic therapy

PubMed Central

Jain, Rakesh K.; Duda, Dan G.; Willett, Christopher G.; Sahani, Dushyant V.; Zhu, Andrew X.; Loeffler, Jay S.; Batchelor, Tracy T.; Sorensen, A. Gregory

2011-01-01

No validated biological markers (or biomarkers) currently exist for appropriately selecting patients with cancer for antiangiogenic therapy. Nor are there biomarkers identifying escape pathways that should be targeted after tumors develop resistance to a given antiangiogenic agent. A number of potential systemic, circulating, tissue and imaging biomarkers have emerged from recently completed phase I–III studies. Some of these are measured at baseline (for example VEGF polymorphisms), others are measured during treatment (such as hypertension, MRI-measured Ktrans, circulating angiogenic molecules or collagen IV), and all are mechanistically based. Some of these biomarkers might be pharmacodynamic (for example, increase in circulating VEGF, placental growth factor) while others have potential for predicting clinical benefit or identifying the escape pathways (for example, stromal-cell-derived factor 1α, interleukin-6). Most biomarkers are disease and/or agent specific and all of them need to be validated prospectively. We discuss the current challenges in establishing biomarkers of antiangiogenic therapy, define systemic, circulating, tissue and imaging biomarkers and their advantages and disadvantages, and comment on the future opportunities for validating biomarkers of antiangiogenic therapy. PMID:19483739

Concurrent systems and time synchronization

NASA Astrophysics Data System (ADS)

Burgin, Mark; Grathoff, Annette

2018-05-01

In the majority of scientific fields, system dynamics is described assuming existence of unique time for the whole system. However, it is established theoretically, for example, in relativity theory or in the system theory of time, and validated experimentally that there are different times and time scales in a variety of real systems - physical, chemical, biological, social, etc. In spite of this, there are no wide-ranging scientific approaches to exploration of such systems. Therefore, the goal of this paper is to study systems with this property. We call them concurrent systems because processes in them can go, events can happen and actions can be performed in different time scales. The problem of time synchronization is specifically explored.

LogScope

NASA Technical Reports Server (NTRS)

Havelund, Klaus; Smith, Margaret H.; Barringer, Howard; Groce, Alex

2012-01-01

LogScope is a software package for analyzing log files. The intended use is for offline post-processing of such logs, after the execution of the system under test. LogScope can, however, in principle, also be used to monitor systems online during their execution. Logs are checked against requirements formulated as monitors expressed in a rule-based specification language. This language has similarities to a state machine language, but is more expressive, for example, in its handling of data parameters. The specification language is user friendly, simple, and yet expressive enough for many practical scenarios. The LogScope software was initially developed to specifically assist in testing JPL s Mars Science Laboratory (MSL) flight software, but it is very generic in nature and can be applied to any application that produces some form of logging information (which almost any software does).

'Pop-Up' Governance: developing internal governance frameworks for consortia: the example of UK10K.

PubMed

Kaye, Jane; Muddyman, Dawn; Smee, Carol; Kennedy, Karen; Bell, Jessica

2015-01-01

Innovations in information technologies have facilitated the development of new styles of research networks and forms of governance. This is evident in genomics where increasingly, research is carried out by large, interdisciplinary consortia focussing on a specific research endeavour. The UK10K project is an example of a human genomics consortium funded to provide insights into the genomics of rare conditions, and establish a community resource from generated sequence data. To achieve its objectives according to the agreed timetable, the UK10K project established an internal governance system to expedite the research and to deal with the complex issues that arose. The project's governance structure exemplifies a new form of network governance called 'pop-up' governance. 'Pop-up' because: it was put together quickly, existed for a specific period, was designed for a specific purpose, and was dismantled easily on project completion. In this paper, we use UK10K to describe how 'pop-up' governance works on the ground and how relational, hierarchical and contractual governance mechanisms are used in this new form of network governance.

Controlling tissue microenvironments: biomimetics, transport phenomena, and reacting systems.

PubMed

Fisher, Robert J; Peattie, Robert A

2007-01-01

The reconstruction of tissues ex vivo and production of cells capable of maintaining a stable performance for extended time periods in sufficient quantity for synthetic or therapeutic purposes are primary objectives of tissue engineering. The ability to characterize and manipulate the cellular microenvironment is critical for successful implementation of such cell-based bioengineered systems. As a result, knowledge of fundamental biomimetics, transport phenomena, and reaction engineering concepts is essential to system design and development. Once the requirements of a specific tissue microenvironment are understood, the biomimetic system specifications can be identified and a design implemented. Utilization of novel membrane systems that are engineered to possess unique transport and reactive features is one successful approach presented here. The limited availability of tissue or cells for these systems dictates the need for microscale reactors. A capstone illustration based on cellular therapy for type 1 diabetes mellitus via encapsulation techniques is presented as a representative example of this approach, to stress the importance of integrated systems.

Tool for Human-Systems Integration Assessment: HSI Scorecard

NASA Technical Reports Server (NTRS)

Whitmore, Nihriban; Sandor, Aniko; McGuire, Kerry M.; Berdich, Debbie

2009-01-01

This paper describes the development and rationale for a human-systems integration (HSI) scorecard that can be used in reviews of vehicle specification and design. This tool can be used to assess whether specific HSI related criteria have been met as part of a project milestone or critical event, such as technical reviews, crew station reviews, mockup evaluations, or even review of major plans or processes. Examples of HSI related criteria include Human Performance Capabilities, Health Management, Human System Interfaces, Anthropometry and Biomechanics, and Natural and Induced Environments. The tool is not intended to evaluate requirements compliance and verification, but to review how well the human related systems have been considered for the specific event and to identify gaps and vulnerabilities from an HSI perspective. The scorecard offers common basis, and criteria for discussions among system managers, evaluators, and design engineers. Furthermore, the scorecard items highlight the main areas of system development that need to be followed during system lifecycle. The ratings provide a repeatable quantitative measure to what has been often seen as only subjective commentary. Thus, the scorecard is anticipated to be a useful HSI tool to communicate review results to the institutional and the project office management.

Carbohydrates, proteins, cell surfaces, and the biochemistry of pathogenesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albersheim, P.; Anderson-Prouty, A.J.

1975-01-01

General plant resistance to pathogenic attack by a myriad of microorganisms, viruses, nematodes, and insects are reviewed. Specifically discussed are: The role of the cell wall and wall-degrading enzymes in infective processes; an hypothesis to account for varietal specificity in gene-for-gene host-pathogen systems; examples which demonstrate that cell surface recognition phenomena are mediated through the interaction of carbohydrate-containing macromolecules and proteins; elicitors of phytoalexin production; and further consideration of the hypothesis and how the gene-for-gene relationship may have evolved. (JWP)

Gliadin Detection in Food by Immunoassay

NASA Astrophysics Data System (ADS)

Grant, Gordon; Sporns, Peter; Hsieh, Y.-H. Peggy

Immunoassays are very sensitive and efficient tests that are commonly used to identify a specific protein. Examples of applications in the food industry include identification of proteins expressed in genetically modified foods, allergens, or proteins associated with a disease, including celiac disease. This genetic disease is associated with Europeans and affects about one in every 200 people in North America. These individuals react immunologically to wheat proteins, and consequently their own immune systems attack and damage their intestines. This disease can be managed if wheat proteins, specifically "gliadins," are avoided in foods.

Automotive Control Systems: For Engine, Driveline, and Vehicle

NASA Astrophysics Data System (ADS)

Kiencke, Uwe; Nielsen, Lars

Advances in automotive control systems continue to enhance safety and comfort and to reduce fuel consumption and emissions. Reflecting the trend to optimization through integrative approaches for engine, driveline, and vehicle control, this valuable book enables control engineers to understand engine and vehicle models necessary for controller design, and also introduces mechanical engineers to vehicle-specific signal processing and automatic control. The emphasis on measurement, comparisons between performance and modeling, and realistic examples derive from the authors' unique industrial experience

Principles of cost-benefit analysis for ERTS experiments, volumes 1 and 2

NASA Technical Reports Server (NTRS)

1973-01-01

The basic elements of a cost-benefit study are discussed along with special considerations for ERTS experiments. Elements required for a complete economic analysis of ERTS are considered to be: statement of objectives, specification of assumptions, enumeration of system alternatives, benefit analysis, cost analysis nonefficiency considerations, and final system selection. A hypothetical cost-benefit example is presented with the assumed objective of an increase in remote sensing surveys of grazing lands to better utilize available forage to lower meat prices.

Accommodating complexity and human behaviors in decision analysis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Backus, George A.; Siirola, John Daniel; Schoenwald, David Alan

2007-11-01

This is the final report for a LDRD effort to address human behavior in decision support systems. One sister LDRD effort reports the extension of this work to include actual human choices and additional simulation analyses. Another provides the background for this effort and the programmatic directions for future work. This specific effort considered the feasibility of five aspects of model development required for analysis viability. To avoid the use of classified information, healthcare decisions and the system embedding them became the illustrative example for assessment.

Recent Developments of Versatile Photoinitiating Systems for Cationic Ring Opening Polymerization Operating at Any Wavelengths and under Low Light Intensity Sources.

PubMed

Lalevée, Jacques; Mokbel, Haifaa; Fouassier, Jean-Pierre

2015-04-20

Photoinitiators (PI) or photoinitiating systems (PIS) usable in light induced cationic polymerization (CP) and free radical promoted cationic polymerization (FRPCP) reactions (more specifically for cationic ring opening polymerization (ROP)) together with the involved mechanisms are briefly reviewed. The recent developments of novel two- and three-component PISs for CP and FRPCP upon exposure to low intensity blue to red lights is emphasized in details. Examples of such reactions under various experimental conditions are provided.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalugin, A. V., E-mail: Kalugin-AV@nrcki.ru; Tebin, V. V.

The specific features of calculation of the effective multiplication factor using the Monte Carlo method for weakly coupled and non-asymptotic multiplying systems are discussed. Particular examples are considered and practical recommendations on detection and Monte Carlo calculation of systems typical in numerical substantiation of nuclear safety for VVER fuel management problems are given. In particular, the problems of the choice of parameters for the batch mode and the method for normalization of the neutron batch, as well as finding and interpretation of the eigenvalue spectrum for the integral fission matrix, are discussed.

Population dynamics in controlled unsteady-state systems: An application to the degradation of glyphosate in a sequencing batch reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devarakonda, M.S.

1988-01-01

Control over population dynamics and organism selection in a biological waste treatment system provides an effective means of engineering process efficiency. Examples of applications of organism selection include control of filamentous organisms, biological nutrient removal, industrial waste treatment requiring the removal of specific substrates, and hazardous waste treatment. Inherently, full scale biological waste treatment systems are unsteady state systems due to the variations in the waste streams and mass flow rates of the substrates. Some systems, however, have the capacity to impose controlled selective pressures on the biological population by means of their operation. An example of such a systemmore » is the Sequencing Batch Reactor (SBR) which was the experimental system utilized in this research work. The concepts of organism selection were studied in detail for the biodegradation of a herbicide waste stream, with glyphosate as the target compound. The SBR provided a reactor configuration capable of exerting the necessary selective pressures to select and enrich for a glyphosate degrading population. Based on results for bench scale SBRs, a hypothesis was developed to explain population dynamics in glyphosate degrading systems.« less

Integrated Safety Analysis Teams

NASA Technical Reports Server (NTRS)

Wetherholt, Jonathan C.

2008-01-01

Today's complex systems require understanding beyond one person s capability to comprehend. Each system requires a team to divide the system into understandable subsystems which can then be analyzed with an Integrated Hazard Analysis. The team must have both specific experiences and diversity of experience. Safety experience and system understanding are not always manifested in one individual. Group dynamics make the difference between success and failure as well as the difference between a difficult task and a rewarding experience. There are examples in the news which demonstrate the need to connect the pieces of a system into a complete picture. The Columbia disaster is now a standard example of a low consequence hazard in one part of the system; the External Tank is a catastrophic hazard cause for a companion subsystem, the Space Shuttle Orbiter. The interaction between the hardware, the manufacturing process, the handling, and the operations contributed to the problem. Each of these had analysis performed, but who constituted the team which integrated this analysis together? This paper will explore some of the methods used for dividing up a complex system; and how one integration team has analyzed the parts. How this analysis has been documented in one particular launch space vehicle case will also be discussed.

"Tracing" Europeanisation: School Leavers' and Graduates' Information Systems as an Example

ERIC Educational Resources Information Center

Hordósy, Rita

2016-01-01

This paper analyses the extent to which the process of Europeanisation can be observed within a specific policy area: that of school leaving and graduation. The paper investigates what is known about school leavers and graduates at the national and the European levels on the one hand, and how the data collections portray Europe and European policy…

ORA User’s Guide 2010

DTIC Science & Technology

2010-06-03

36 Stargate Summit - Synopsis...Started Welcome to ORA’s Help File system! The ORA Help and examples contained herein are written with a specific data set in mind: Stargate -SG1. More...www.casos.cs.cmu.edu/computational_tools/datasets/inter nal/ stargate /index2.html As an added data set to use, a network model of The Tragedy of Julius Caesar will

Black, White, Green, Red. The Politics of Education in Ethnic America.

ERIC Educational Resources Information Center

Bresnick, David; And Others

The upheaval in large city school systems during the late 1960s and early 1970s is examined in this book. Most of the specific examples are drawn from school districts in New York City, such as Ocean Hill-Brownsville and Canarsie. The problems of growing demands for community control, ethnic and racial conflicts, and school decentralization are…

Assessing the 'relative value' of diabetic patients treated through an incentivized, corporate compliance model.

PubMed

Oldani, Michael J

2010-08-01

Primary Care clinics in the United States continue to incentivize doctors to adhere to clinical guidelines regarding record keeping and managing specific patient disorders. This paper offers a case study of a US physician working in a system of total compliance. This narrative will illustrate how a specific system has emerged that pays doctors an end-of-year bonus for achieving compliance in four specific areas: record keeping, service hours, customer satisfaction surveys, and maintaining tight control of diabetic patients. In particular, special attention is paid to the emphasis on 'the numbers' within the corporate compliance model, and specifically, the relative value units (RVUs) used for structuring billing, labeling patients, and organizing the day-to-day activities of doctors. Although incentivized models of compliance have proved effective in managing both doctors and patients, especially in the UK, 'gaming' the system can occur. This paper identifies one example of how patients assume a hidden risk within this model by potentially being labeled noncompliant by having the wrong numbers, even when receiving good clinical care and acting medically compliant.

The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 1 Core

PubMed Central

Hucka, Michael; Bergmann, Frank T.; Hoops, Stefan; Keating, Sarah M.; Sahle, Sven; Schaff, James C.; Smith, Lucian P.; Wilkinson, Darren J.

2017-01-01

Summary Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 1 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/. PMID:26528564

The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 1 Core.

PubMed

Hucka, Michael; Bergmann, Frank T; Hoops, Stefan; Keating, Sarah M; Sahle, Sven; Schaff, James C; Smith, Lucian P; Wilkinson, Darren J

2015-09-04

Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 1 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/.

The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 1 Core.

PubMed

Hucka, Michael; Bergmann, Frank T; Hoops, Stefan; Keating, Sarah M; Sahle, Sven; Schaff, James C; Smith, Lucian P; Wilkinson, Darren J

2015-06-01

Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 1 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/.

Rasmussen's legacy: A paradigm change in engineering for safety.

PubMed

Leveson, Nancy G

2017-03-01

This paper describes three applications of Rasmussen's idea to systems engineering practice. The first is the application of the abstraction hierarchy to engineering specifications, particularly requirements specification. The second is the use of Rasmussen's ideas in safety modeling and analysis to create a new, more powerful type of accident causation model that extends traditional models to better handle human-operated, software-intensive, sociotechnical systems. Because this new model has a formal, mathematical foundation built on systems theory (as was Rasmussen's original model), new modeling and analysis tools become possible. The third application is to engineering hazard analysis. Engineers have traditionally either omitted human from consideration in system hazard analysis or have treated them rather superficially, for example, that they behave randomly. Applying Rasmussen's model of human error to a powerful new hazard analysis technique allows human behavior to be included in engineering hazard analysis. Copyright © 2016 Elsevier Ltd. All rights reserved.

Technology Area Roadmap for In Space Propulsion Technologies

NASA Technical Reports Server (NTRS)

Johnson, Les; Meyer, Mike; Coote, David; Goebel, Dan; Palaszewski, Bryan; White, Sonny

2010-01-01

This slide presentation reviews the technology area (TA) roadmap to develop propulsion technologies that will be used to enable further exploration of the solar system, and beyond. It is hoped that development of the technologies within this TA will result in technical solutions that will improve thrust levels, specific impulse, power, specific mass, volume, system mass, system complexity, operational complexity, commonality with other spacecraft systems, manufacturability and durability. Some of the propulsion technologies that are reviewed include: chemical and non-chemical propulsion, and advanced propulsion (i.e., those with a Technology Readiness level of less than 3). Examples of these advanced technologies include: Beamed Energy, Electric Sail, Fusion, High Energy Density Materials, Antimatter, Advanced Fission and Breakthrough propulsion technologies. Timeframes for development of some of these propulsion technologies are reviewed, and top technical challenges are reviewed. This roadmap describes a portfolio of in-space propulsion technologies that can meet future space science and exploration needs.

Physiologically relevant organs on chips

PubMed Central

Yum, Kyungsuk; Hong, Soon Gweon; Lee, Luke P.

2015-01-01

Recent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine and pharmaceutical research. Here we review the recent development of microengineered physiological systems, or organs on chips, that reconstitute the physiologically critical features of specific human tissues and organs and their interactions. This technology uses microengineering approaches to construct organ-specific microenvironments, reconstituting tissue structures, tissue–tissue interactions and interfaces, and dynamic mechanical and biochemical stimuli found in specific organs, to direct cells to assemble into functional tissues. We first discuss microengineering approaches to reproduce the key elements of physiologically important, dynamic mechanical microenvironments, biochemical microenvironments, and microarchitectures of specific tissues and organs in microfluidic cell culture systems. This is followed by examples of microengineered individual organ models that incorporate the key elements of physiological microenvironments into single microfluidic cell culture systems to reproduce organ-level functions. Finally, microengineered multiple organ systems that simulate multiple organ interactions to better represent human physiology, including human responses to drugs, is covered in this review. This emerging organs-on-chips technology has the potential to become an alternative to 2D and 3D cell culture and animal models for experimental medicine, human disease modeling, drug development, and toxicology. PMID:24357624

Opportunities and Examples for Integration of Socio-environmental Approaches to Support Climate-informed Decisions

NASA Astrophysics Data System (ADS)

Kenney, M. A.

2014-12-01

Climate and environmental decisions require science that couples human and natural systems to quantify or articulate the observed physical, natural, and societal changes or likely consequences of different decision options. Despite the need for such policy-relevant research, multidisciplinary collaborations can be wrought with challenges of data integration, model interoperability, and communication across disciplinary divides. In this talk, I will present several examples where I have collaborated with colleagues from the physical, natural, and social sciences to develop novel, actionable science to inform decision-making. Specifically, I will discuss a cost analysis of water and sediment diversions to optimize land building in the Mississippi River delta (winner of American Geophysical Union Water Resources Research Editor's Choice Award 2014) and the development of a National Climate Indicator System that uses knowledge across the physical, natural, and social sciences to establish an end-to-end indicator system of climate changes, impacts, vulnerabilities, and responses. The latter project is in the process of moving from research to operations, an additional challenge and opportunity, as we work with the U.S. Global Change Research Program and their affiliated Federal agencies to establish it beyond the research prototype. Using these examples, I will provide some lessons learned that would have general applicability to socio-environmental research collaborations and integration of data, models, and information systems to support climate and environmental decision-making.

The Cancer Prevention and Control Research Network: An Interactive Systems Approach to Advancing Cancer Control Implementation Research and Practice

PubMed Central

Fernández, María E.; Melvin, Cathy L.; Leeman, Jennifer; Ribisl, Kurt M.; Allen, Jennifer D.; Kegler, Michelle C.; Bastani, Roshan; Ory, Marcia G.; Risendal, Betsy C.; Hannon, Peggy A.; Kreuter, Matthew W.; Hebert, James R.

2018-01-01

Background Although cancer research has advanced at a rapid pace, a gap remains between what is known about how to improve cancer prevention and control (CPC) and what is implemented as best practices within health care systems and communities. The Cancer Prevention and Control Research Network (CPCRN), with more than 10 years of dissemination and implementation research experience, aims to accelerate the uptake and use of evidence-based CPC interventions. Methods The collective work of the CPCRN has facilitated the analysis and categorization of research and implementation efforts according to the Interactive Systems Framework for Dissemination and Implementation (ISF), providing a useful heuristic for bridging the gap between prevention research and practice. The ISF authors have called for examples of its application as input to help refine the model. Results We provide examples of how the collaborative activities supported by the CPCRN, using community-engaged processes, accelerated the synthesis and translation of evidence, built both general and innovation-specific capacity, and worked with delivery systems to advance cancer control research and practice. Conclusions The work of the CPCRN has provided real-world examples of the application of the ISF and demonstrated that synthesizing and translating evidence can increase the potential that evidence-based CPC programs will be used and that capacity building for both the support system and the delivery system is crucial for the successful implementation and maintenance of evidence-based cancer control. Impact Adoption and implementation of CPC can be enhanced by better understanding ISF systems and intervening to improve them. PMID:25155759

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.

PubMed

Johansson, Anna-Mia; Stenberg, Per; Bernhardsson, Carolina; Larsson, Jan

2007-05-02

Drosophila melanogaster exhibits two expression-regulating systems that target whole, specific chromosomes: the dosage compensation system whereby the male-specific lethal complex doubles transcription of genes on the male X-chromosome and the chromosome 4-specific protein Painting of fourth, POF. POF is the first example of an autosome-specific protein and its presence raises the question of the universality of chromosome-specific regulation. Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome. Contrary to previous conclusions, Pof is not essential for survival of diplo-4th karyotype flies. However, Pof is essential for survival of haplo-4th individuals and expression of chromosome 4 genes in diplo-4th individuals is decreased in the absence of Pof. Mapping of POF using chromatin immunoprecipitation suggested that it binds within genes. Furthermore, we show that POF binding is dependent on heterochromatin and that POF and HP1 bind interdependently to the 4th chromosome. We propose a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome.

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster

PubMed Central

Johansson, Anna-Mia; Stenberg, Per; Bernhardsson, Carolina; Larsson, Jan

2007-01-01

Drosophila melanogaster exhibits two expression-regulating systems that target whole, specific chromosomes: the dosage compensation system whereby the male-specific lethal complex doubles transcription of genes on the male X-chromosome and the chromosome 4-specific protein Painting of fourth, POF. POF is the first example of an autosome-specific protein and its presence raises the question of the universality of chromosome-specific regulation. Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome. Contrary to previous conclusions, Pof is not essential for survival of diplo-4th karyotype flies. However, Pof is essential for survival of haplo-4th individuals and expression of chromosome 4 genes in diplo-4th individuals is decreased in the absence of Pof. Mapping of POF using chromatin immunoprecipitation suggested that it binds within genes. Furthermore, we show that POF binding is dependent on heterochromatin and that POF and HP1 bind interdependently to the 4th chromosome. We propose a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome. PMID:17318176

CONDUIT: A New Multidisciplinary Integration Environment for Flight Control Development

NASA Technical Reports Server (NTRS)

Tischler, Mark B.; Colbourne, Jason D.; Morel, Mark R.; Biezad, Daniel J.; Levine, William S.; Moldoveanu, Veronica

1997-01-01

A state-of-the-art computational facility for aircraft flight control design, evaluation, and integration called CONDUIT (Control Designer's Unified Interface) has been developed. This paper describes the CONDUIT tool and case study applications to complex rotary- and fixed-wing fly-by-wire flight control problems. Control system analysis and design optimization methods are presented, including definition of design specifications and system models within CONDUIT, and the multi-objective function optimization (CONSOL-OPTCAD) used to tune the selected design parameters. Design examples are based on flight test programs for which extensive data are available for validation. CONDUIT is used to analyze baseline control laws against pertinent military handling qualities and control system specifications. In both case studies, CONDUIT successfully exploits trade-offs between forward loop and feedback dynamics to significantly improve the expected handling, qualities and minimize the required actuator authority. The CONDUIT system provides a new environment for integrated control system analysis and design, and has potential for significantly reducing the time and cost of control system flight test optimization.

On the role of general system theory for functional neuroimaging.

PubMed

Stephan, Klaas Enno

2004-12-01

One of the most important goals of neuroscience is to establish precise structure-function relationships in the brain. Since the 19th century, a major scientific endeavour has been to associate structurally distinct cortical regions with specific cognitive functions. This was traditionally accomplished by correlating microstructurally defined areas with lesion sites found in patients with specific neuropsychological symptoms. Modern neuroimaging techniques with high spatial resolution have promised an alternative approach, enabling non-invasive measurements of regionally specific changes of brain activity that are correlated with certain components of a cognitive process. Reviewing classic approaches towards brain structure-function relationships that are based on correlational approaches, this article argues that these approaches are not sufficient to provide an understanding of the operational principles of a dynamic system such as the brain but must be complemented by models based on general system theory. These models reflect the connectional structure of the system under investigation and emphasize context-dependent couplings between the system elements in terms of effective connectivity. The usefulness of system models whose parameters are fitted to measured functional imaging data for testing hypotheses about structure-function relationships in the brain and their potential for clinical applications is demonstrated by several empirical examples.

On the role of general system theory for functional neuroimaging

PubMed Central

Stephan, Klaas Enno

2004-01-01

One of the most important goals of neuroscience is to establish precise structure–function relationships in the brain. Since the 19th century, a major scientific endeavour has been to associate structurally distinct cortical regions with specific cognitive functions. This was traditionally accomplished by correlating microstructurally defined areas with lesion sites found in patients with specific neuropsychological symptoms. Modern neuroimaging techniques with high spatial resolution have promised an alternative approach, enabling non-invasive measurements of regionally specific changes of brain activity that are correlated with certain components of a cognitive process. Reviewing classic approaches towards brain structure–function relationships that are based on correlational approaches, this article argues that these approaches are not sufficient to provide an understanding of the operational principles of a dynamic system such as the brain but must be complemented by models based on general system theory. These models reflect the connectional structure of the system under investigation and emphasize context-dependent couplings between the system elements in terms of effective connectivity. The usefulness of system models whose parameters are fitted to measured functional imaging data for testing hypotheses about structure–function relationships in the brain and their potential for clinical applications is demonstrated by several empirical examples. PMID:15610393

Formalizing structured file services for the data storage and retrieval subsystem of the data management system for Spacestation Freedom

NASA Technical Reports Server (NTRS)

Jamsek, Damir A.

1993-01-01

A brief example of the use of formal methods techniques in the specification of a software system is presented. The report is part of a larger effort targeted at defining a formal methods pilot project for NASA. One possible application domain that may be used to demonstrate the effective use of formal methods techniques within the NASA environment is presented. It is not intended to provide a tutorial on either formal methods techniques or the application being addressed. It should, however, provide an indication that the application being considered is suitable for a formal methods by showing how such a task may be started. The particular system being addressed is the Structured File Services (SFS), which is a part of the Data Storage and Retrieval Subsystem (DSAR), which in turn is part of the Data Management System (DMS) onboard Spacestation Freedom. This is a software system that is currently under development for NASA. An informal mathematical development is presented. Section 3 contains the same development using Penelope (23), an Ada specification and verification system. The complete text of the English version Software Requirements Specification (SRS) is reproduced in Appendix A.

How Engineers Negotiate Domain Boundaries in a Complex, Interdisciplinary Engineering Project

NASA Technical Reports Server (NTRS)

Panther, Grace; Montfort, Devlin; Pirtle, Zachary

2017-01-01

Engineering educators have an essential role in preparing engineers to work in a complex, interdisciplinary workforce. While much engineering education focuses on teaching students to develop disciplinary expertise in specific engineering domains, there is a strong need to teach engineers about the knowledge that they develop or use in their work (Bucciarelli 1994, Allenby Sarewitz, 2011; Frodeman, 2013). The purpose of this research is to gain a better understanding of the knowledge systems of practicing engineers through observations of their practices such that the insights learned can guide future education efforts. Using an example from a complex and interdisciplinary engineering project, this paper presents a case study overviewing the types of epistemological (or knowledge-acquiring or using) complexities that engineers navigate. Specifically, we looked at a discussion of the thermal design of a CubeSat that occurred during an engineering review at NASA. We analyzed the review using a framework that we call 'peak events', or pointed discussions between reviewers, project engineers, and managers. We examined the dialog within peak events to identify the ways that knowledge was brought to bear, highlighting discussions of uncertainty and the boundaries of knowledge claims. We focus on one example discussion surrounding the thermal design of the CubeSat, which provides a particularly thorough example of a knowledge system since the engineers present explained, justified, negotiated, and defended knowledge within a social setting. Engineering students do not get much practice or instruction in explicitly negotiating knowledge systems and epistemic standards in this way. We highlight issues that should matter to engineering educators, such as the need to discuss what level of uncertainty is sufficient and the need to negotiate boundaries of system responsibility. Although this analysis is limited to a single discussion or 'peak event', our case shows that this type of discussion can occur in engineering and suggests that it could be important for future engineering education research.

Systems biology: the case for a systems science approach to diabetes.

PubMed

Petrasek, Danny

2008-01-01

The unprecedented accumulation of biological data in recent decades has underscored the need to organize and integrate the massive collection of information. In addition, there is rising agreement among biologists that a complete understanding of a single cell will not lead directly to a complete understanding of a system of cells. The success of a systems science approach in engineering and physics may be of great value in the evolution of biological science. This article reviews some examples that suggest the importance of a systems biology approach and, in addition, advance one specific systems science principle, the conservation of uncertainty, which may give insight into the emergent behavior of numerous biological and physiological phenomena.

Building a computer-aided design capability using a standard time share operating system

NASA Technical Reports Server (NTRS)

Sobieszczanski, J.

1975-01-01

The paper describes how an integrated system of engineering computer programs can be built using a standard commercially available operating system. The discussion opens with an outline of the auxiliary functions that an operating system can perform for a team of engineers involved in a large and complex task. An example of a specific integrated system is provided to explain how the standard operating system features can be used to organize the programs into a simple and inexpensive but effective system. Applications to an aircraft structural design study are discussed to illustrate the use of an integrated system as a flexible and efficient engineering tool. The discussion concludes with an engineer's assessment of an operating system's capabilities and desirable improvements.

Evaluation of automated decisionmaking methodologies and development of an integrated robotic system simulation, appendix A

NASA Technical Reports Server (NTRS)

Haley, D. C.; Almand, B. J.; Thomas, M. M.; Krauze, L. D.; Gremban, K. D.; Sanborn, J. C.; Kelly, J. H.; Depkovich, T. M.

1984-01-01

A generic computer simulation for manipulator systems (ROBSIM) was implemented and the specific technologies necessary to increase the role of automation in various missions were developed. The specific items developed were: (1) Capability for definition of a manipulator system consisting of multiple arms, load objects, and an environment; (2) Capability for kinematic analysis, requirements analysis, and response simulation of manipulator motion; (3) Postprocessing options such as graphic replay of simulated motion and manipulator parameter plotting; (4) Investigation and simulation of various control methods including manual force/torque and active compliance control; (5) Evaluation and implementation of three obstacle avoidance methods; (6) Video simulation and edge detection; and (7) Software simulation validation. This appendix is the user's guide and includes examples of program runs and outputs as well as instructions for program use.

Yeast Two-Hybrid: State of the Art

PubMed Central

Beyaert, Rudi

1999-01-01

Genome projects are approaching completion and are saturating sequence databases. This paper discusses the role of the two-hybrid system as a generator of hypotheses. Apart from this rather exhaustive, financially and labour intensive procedure, more refined functional studies can be undertaken. Indeed, by making hybrids of two-hybrid systems, customised approaches can be developed in order to attack specific function-related problems. For example, one could set-up a "differential" screen by combining a forward and a reverse approach in a three-hybrid set-up. Another very interesting project is the use of peptide libraries in two-hybrid approaches. This could enable the identification of peptides with very high specificity comparable to "real" antibodies. With the technology available, the only limitation is imagination. PMID:12734586

Detection of small molecules with a flow immunosensor

NASA Technical Reports Server (NTRS)

Kusterbeck, Anne W.; Ligler, Frances S.

1991-01-01

We describe the development of an easy-to-use sensor with widespread applications for detecting small molecules. The flow immunosensor can analyze discrete samples in under one minute or continuously monitor a flowing stream for the presence of specific analytes. This detection system is extremely specific, and achieves a level of sensitivity which meets or exceeds the detection limits reported for rival assays. Because the system is also compact, transportable, and automated, it has the potential to impact diverse areas. For example, the flow immunosensor has successfully detected drugs of abuse and explosives, and may well address many of the needs of the environmental community with respect to continuous monitoring for pollutants. Efforts are underway to engineer a portable device in the field.

A Nuclear Cryogenic Propulsion Stage for Near-Term Space Missions

NASA Technical Reports Server (NTRS)

Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Doughty, Glen E.; Adams, Robert B.; Bechtel, Ryan D.; Borowski, Stanley K.;

Re-Engineering JPL's Mission Planning Ground System Architecture for Cost Efficient Operations in the 21st Century

NASA Technical Reports Server (NTRS)

Fordyce, Jess

1996-01-01

Work carried out to re-engineer the mission analysis segment of JPL's mission planning ground system architecture is reported on. The aim is to transform the existing software tools, originally developed for specific missions on different support environments, into an integrated, general purpose, multi-mission tool set. The issues considered are: the development of a partnership between software developers and users; the definition of key mission analysis functions; the development of a consensus based architecture; the move towards evolutionary change instead of revolutionary replacement; software reusability, and the minimization of future maintenance costs. The current status and aims of new developments are discussed and specific examples of cost savings and improved productivity are presented.

Transcranial Magnetic Stimulation: Decomposing the Processes Underlying Action Preparation.

PubMed

Bestmann, Sven; Duque, Julie

2016-08-01

Preparing actions requires the operation of several cognitive control processes that influence the state of the motor system to ensure that the appropriate behavior is ultimately selected and executed. For example, some form of competition resolution ensures that the right action is chosen among alternatives, often in the presence of conflict; at the same time, impulse control ought to be deployed to prevent premature responses. Here we review how state-changes in the human motor system during action preparation can be studied through motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation over the contralateral primary motor cortex (M1). We discuss how the physiological fingerprints afforded by MEPs have helped to decompose some of the dynamic and effector-specific influences on the motor system during action preparation. We focus on competition resolution, conflict and impulse control, as well as on the influence of higher cognitive decision-related variables. The selected examples demonstrate the usefulness of MEPs as physiological readouts for decomposing the influence of distinct, but often overlapping, control processes on the human motor system during action preparation. © The Author(s) 2015.

Multilevel Complex Networks and Systems

NASA Astrophysics Data System (ADS)

Caldarelli, Guido

2014-03-01

Network theory has been a powerful tool to model isolated complex systems. However, the classical approach does not take into account the interactions often present among different systems. Hence, the scientific community is nowadays concentrating the efforts on the foundations of new mathematical tools for understanding what happens when multiple networks interact. The case of economic and financial networks represents a paramount example of multilevel networks. In the case of trade, trade among countries the different levels can be described by the different granularity of the trading relations. Indeed, we have now data from the scale of consumers to that of the country level. In the case of financial institutions, we have a variety of levels at the same scale. For example one bank can appear in the interbank networks, ownership network and cds networks in which the same institution can take place. In both cases the systemically important vertices need to be determined by different procedures of centrality definition and community detection. In this talk I will present some specific cases of study related to these topics and present the regularities found. Acknowledged support from EU FET Project ``Multiplex'' 317532.

An Overview of Clinical and Commercial Impact of Drug Delivery Systems

PubMed Central

Anselmo, Aaron C.; Mitragotri, Samir

2014-01-01

Drug delivery systems are widely researched and developed to improve the delivery of pharmaceutical compounds and molecules. The last few decades have seen a marked growth of the field fueled by increased number of researchers, research funding, venture capital and the number of start-ups. Collectively, the growth has led to novel systems that make use of micro/nano-particles, transdermal patches, inhalers, drug reservoir implants and antibody-drug conjugates. While the increased research activity is clearly an indication of proliferation of the field, clinical and commercial translation of early-stage research ideas is critically important for future growth and interest in the field. Here, we will highlight some of the examples of novel drug delivery systems that have undergone such translation. Specifically, we will discuss the developments, advantages, limitations and lessons learned from: (i) microparticle-based depot formulations, (ii) nanoparticle-based cancer drugs, (iii) transdermal systems, (iv) oral drug delivery systems, (v) pulmonary drug delivery, (vi) implants and (vii) antibody-drug conjugates. These systems have impacted treatment of many prevalent diseases including diabetes, cancer and cardiovascular diseases, among others. At the same time, these systems are integral and enabling components of products that collectively generate annual revenues exceeding US $100 billion. These examples provide strong evidence of the clinical and commercial impact of drug delivery systems. PMID:24747160

System Simulation by Recursive Feedback: Coupling A Set of Stand-Alone Subsystem Simulations

NASA Technical Reports Server (NTRS)

Nixon, Douglas D.; Hanson, John M. (Technical Monitor)

2002-01-01

Recursive feedback is defined and discussed as a framework for development of specific algorithms and procedures that propagate the time-domain solution for a dynamical system simulation consisting of multiple numerically coupled self-contained stand-alone subsystem simulations. A satellite motion example containing three subsystems (other dynamics, attitude dynamics, and aerodynamics) has been defined and constructed using this approach. Conventional solution methods are used in the subsystem simulations. Centralized and distributed versions of coupling structure have been addressed. Numerical results are evaluated by direct comparison with a standard total-system simultaneous-solution approach.

ADA, the Programming Language of Choice for the UPMSat-2 Satellite

NASA Astrophysics Data System (ADS)

Garrido, Jorge; Zamorano, Juan; de la Puente, Juan A.; Alonso, Alejandro; Salazar, Emilio

2015-09-01

The proper selection of development mechanisms and tools is essential for the final success of any engineering project. This is also true when it comes to software development. Furthermore, when the system shows very specific and hard to meet requirements, as it happens for high-integrity real-time systems, the appropriate selection is crucial. For this kind of systems, Ada has proven to be a successful companion, and satellites are not an exception. The paper presents the reasons behind the selection of Ada for the UPMSat-2 development, along with the experience and examples on its usage.

High resolution image processing on low-cost microcomputers

NASA Technical Reports Server (NTRS)

Miller, R. L.

1993-01-01

Recent advances in microcomputer technology have resulted in systems that rival the speed, storage, and display capabilities of traditionally larger machines. Low-cost microcomputers can provide a powerful environment for image processing. A new software program which offers sophisticated image display and analysis on IBM-based systems is presented. Designed specifically for a microcomputer, this program provides a wide-range of functions normally found only on dedicated graphics systems, and therefore can provide most students, universities and research groups with an affordable computer platform for processing digital images. The processing of AVHRR images within this environment is presented as an example.

A simulation of remote sensor systems and data processing algorithms for spectral feature classification

NASA Technical Reports Server (NTRS)

Arduini, R. F.; Aherron, R. M.; Samms, R. W.

1984-01-01

A computational model of the deterministic and stochastic processes involved in multispectral remote sensing was designed to evaluate the performance of sensor systems and data processing algorithms for spectral feature classification. Accuracy in distinguishing between categories of surfaces or between specific types is developed as a means to compare sensor systems and data processing algorithms. The model allows studies to be made of the effects of variability of the atmosphere and of surface reflectance, as well as the effects of channel selection and sensor noise. Examples of these effects are shown.

Congruence Approximations for Entrophy Endowed Hyperbolic Systems

NASA Technical Reports Server (NTRS)

Barth, Timothy J.; Saini, Subhash (Technical Monitor)

1998-01-01

Building upon the standard symmetrization theory for hyperbolic systems of conservation laws, congruence properties of the symmetrized system are explored. These congruence properties suggest variants of several stabilized numerical discretization procedures for hyperbolic equations (upwind finite-volume, Galerkin least-squares, discontinuous Galerkin) that benefit computationally from congruence approximation. Specifically, it becomes straightforward to construct the spatial discretization and Jacobian linearization for these schemes (given a small amount of derivative information) for possible use in Newton's method, discrete optimization, homotopy algorithms, etc. Some examples will be given for the compressible Euler equations and the nonrelativistic MHD equations using linear and quadratic spatial approximation.

Game engines and immersive displays

NASA Astrophysics Data System (ADS)

Chang, Benjamin; Destefano, Marc

2014-02-01

While virtual reality and digital games share many core technologies, the programming environments, toolkits, and workflows for developing games and VR environments are often distinct. VR toolkits designed for applications in visualization and simulation often have a different feature set or design philosophy than game engines, while popular game engines often lack support for VR hardware. Extending a game engine to support systems such as the CAVE gives developers a unified development environment and the ability to easily port projects, but involves challenges beyond just adding stereo 3D visuals. In this paper we outline the issues involved in adapting a game engine for use with an immersive display system including stereoscopy, tracking, and clustering, and present example implementation details using Unity3D. We discuss application development and workflow approaches including camera management, rendering synchronization, GUI design, and issues specific to Unity3D, and present examples of projects created for a multi-wall, clustered, stereoscopic display.

A word processor optimized for preparing journal articles and student papers.

PubMed

Wolach, A H; McHale, M A

2001-11-01

A new Windows-based word processor for preparing journal articles and student papers is described. In addition to standard features found in word processors, the present word processor provides specific help in preparing manuscripts. Clicking on "Reference Help (APA Form)" in the "File" menu provides a detailed help system for entering the references in a journal article. Clicking on "Examples and Explanations of APA Form" provides a help system with examples of the various sections of a review article, journal article that has one experiment, or journal article that has two or more experiments. The word processor can automatically place the manuscript page header and page number at the top of each page using the form required by APA and Psychonomic Society journals. The "APA Form" submenu of the "Help" menu provides detailed information about how the word processor is optimized for preparing articles and papers.

Innovation and Transformation in California’s Safety-net Healthcare Settings: An Inside Perspective

PubMed Central

Lyles, Courtney R.; Aulakh, Veenu; Jameson, Wendy; Schillinger, Dean; Yee, Hal; Sarkar, Urmimala

2016-01-01

Background Health reform requires safety-net settings to transform care delivery, but how they will innovate in order to achieve this transformation is unknown. Methods We conducted two series of key informant interviews (N= 28) in 2012 with leadership from both California’s public hospital systems and community health centers. Interviews focused on how innovation was conceptualized and solicited examples of successful innovations. Results In contrast to disruptive innovation, interviewees often defined innovation as improving implementation, making incremental changes, and promoting integration. Many leaders gave examples of existing innovative practices such as patient-centered approaches to meeting their diverse patient needs. Participants expressed challenges to adapting quickly, but a desire to partner together. Conclusions Safety-net systems have already begun implementing innovative practices supporting their key priority areas. However, more support is needed, specifically to accelerate the change needed to succeed under health reform. PMID:24170938

The role of infectious disease in marine communities: chapter 5

USGS Publications Warehouse

Lafferty, Kevin D.; Harvell, C. Drew

2014-01-01

Marine ecologists recognize that infectious diseases play and important role in ocean ecosystems. This role may have increased in some host taxa over time (Ward and Lafferty 2004). We begin this chapter by introducing infectious agents and their relationships with their hosts in marine systems. We then put infectious disease agents with their hosts in marine systems. We then put infectious disease agents in the perspective of marine biodiversity and discuss the various factors that affect parasites. Specifically, we introduce some basin epidemiological concepts, including the effects of stress and free-living diversity on parasites. Following this, we give brief consideration to communities of parasites within their hosts, particularly as these can lead to general insights into community ecology. We also give examples of how infectious diseases affect host populations, scaling up to marine communities. Finally, we present examples of marine infectious disease that impair conservation and fisheries.

Query construction, entropy, and generalization in neural-network models

NASA Astrophysics Data System (ADS)

Sollich, Peter

1994-05-01

We study query construction algorithms, which aim at improving the generalization ability of systems that learn from examples by choosing optimal, nonredundant training sets. We set up a general probabilistic framework for deriving such algorithms from the requirement of optimizing a suitable objective function; specifically, we consider the objective functions entropy (or information gain) and generalization error. For two learning scenarios, the high-low game and the linear perceptron, we evaluate the generalization performance obtained by applying the corresponding query construction algorithms and compare it to training on random examples. We find qualitative differences between the two scenarios due to the different structure of the underlying rules (nonlinear and ``noninvertible'' versus linear); in particular, for the linear perceptron, random examples lead to the same generalization ability as a sequence of queries in the limit of an infinite number of examples. We also investigate learning algorithms which are ill matched to the learning environment and find that, in this case, minimum entropy queries can in fact yield a lower generalization ability than random examples. Finally, we study the efficiency of single queries and its dependence on the learning history, i.e., on whether the previous training examples were generated randomly or by querying, and the difference between globally and locally optimal query construction.

Design of robust iterative learning control schemes for systems with polytopic uncertainties and sector-bounded nonlinearities

NASA Astrophysics Data System (ADS)

Boski, Marcin; Paszke, Wojciech

2017-01-01

This paper deals with designing of iterative learning control schemes for uncertain systems with static nonlinearities. More specifically, the nonlinear part is supposed to be sector bounded and system matrices are assumed to range in the polytope of matrices. For systems with such nonlinearities and uncertainties the repetitive process setting is exploited to develop a linear matrix inequality based conditions for computing the feedback and feedforward (learning) controllers. These controllers guarantee acceptable dynamics along the trials and ensure convergence of the trial-to-trial error dynamics, respectively. Numerical examples illustrate the theoretical results and confirm effectiveness of the designed control scheme.

Selective Infection of Antigen-Specific B Lymphocytes by Salmonella Mediates Bacterial Survival and Systemic Spreading of Infection

PubMed Central

de Wit, Jelle; Martinoli, Chiara; Zagato, Elena; Janssen, Hans; Jorritsma, Tineke; Bar-Ephraïm, Yotam E.; Rescigno, Maria; Neefjes, Jacques; van Ham, S. Marieke

2012-01-01

Background The bacterial pathogen Salmonella causes worldwide disease. A major route of intestinal entry involves M cells, providing access to B cell-rich Peyer’s Patches. Primary human B cells phagocytose Salmonella typhimurium upon recognition by the specific surface Ig receptor (BCR). As it is unclear how Salmonella disseminates systemically, we studied whether Salmonella can use B cells as a transport device for spreading. Methodology/Principal Findings Human primary B cells or Ramos cell line were incubated with GFP-expressing Salmonella. Intracellular survival and escape was studied in vitro by live cell imaging, flow cytometry and flow imaging. HEL-specific B cells were transferred into C57BL/6 mice and HEL-expressing Salmonella spreading in vivo was analyzed investigating mesenteric lymph nodes, spleen and blood. After phagocytosis by B cells, Salmonella survives intracellularly in a non-replicative state which is actively maintained by the B cell. Salmonella is later excreted followed by reproductive infection of other cell types. Salmonella-specific B cells thus act both as a survival niche and a reservoir for reinfection. Adoptive transfer of antigen-specific B cells before oral infection of mice showed that these B cells mediate in vivo systemic spreading of Salmonella to spleen and blood. Conclusions/Significance This is a first example of a pathogenic bacterium that abuses the antigen-specific cells of the adaptive immune system for systemic spreading for dissemination of infection. PMID:23209805

The Gaia mission a rich resource for outreach activities

NASA Astrophysics Data System (ADS)

O'Flaherty, K. S.; Douglas, J.; Prusti, T.

2008-07-01

Space science missions, and astronomy missions in particular, capture the public imagination at all levels. ESA's Gaia mission is no exception to this. In addition to its key scientific goal of providing new insight into the origin, formation, and evolution of the Milky Way, Gaia also touches on many other scientific topics of broad appeal, for example, solar system objects, stars (including rare and exotic ones), dark matter, gravitational light bending. The mission naturally provides a rich resource for outreach possibilities whether it be to the general public, or to specific interest groups, such as scientists from other fields or educators. We present some examples of possible outreach activities for Gaia.

Performance seeking control (PSC) for the F-15 highly integrated digital electronic control (HIDEC) aircraft

NASA Technical Reports Server (NTRS)

Orme, John S.

1995-01-01

The performance seeking control algorithm optimizes total propulsion system performance. This adaptive, model-based optimization algorithm has been successfully flight demonstrated on two engines with differing levels of degradation. Models of the engine, nozzle, and inlet produce reliable, accurate estimates of engine performance. But, because of an observability problem, component levels of degradation cannot be accurately determined. Depending on engine-specific operating characteristics PSC achieves various levels performance improvement. For example, engines with more deterioration typically operate at higher turbine temperatures than less deteriorated engines. Thus when the PSC maximum thrust mode is applied, for example, there will be less temperature margin available to be traded for increasing thrust.

Numerical approximations for fractional diffusion equations via a Chebyshev spectral-tau method

NASA Astrophysics Data System (ADS)

Doha, Eid H.; Bhrawy, Ali H.; Ezz-Eldien, Samer S.

2013-10-01

In this paper, a class of fractional diffusion equations with variable coefficients is considered. An accurate and efficient spectral tau technique for solving the fractional diffusion equations numerically is proposed. This method is based upon Chebyshev tau approximation together with Chebyshev operational matrix of Caputo fractional differentiation. Such approach has the advantage of reducing the problem to the solution of a system of algebraic equations, which may then be solved by any standard numerical technique. We apply this general method to solve four specific examples. In each of the examples considered, the numerical results show that the proposed method is of high accuracy and is efficient for solving the time-dependent fractional diffusion equations.

Emergence of Coding and its Specificity as a Physico-Informatic Problem

NASA Astrophysics Data System (ADS)

Wills, Peter R.; Nieselt, Kay; McCaskill, John S.

2015-06-01

We explore the origin-of-life consequences of the view that biological systems are demarcated from inanimate matter by their possession of referential information, which is processed computationally to control choices of specific physico-chemical events. Cells are cybernetic: they use genetic information in processes of communication and control, subjecting physical events to a system of integrated governance. The genetic code is the most obvious example of how cells use information computationally, but the historical origin of the usefulness of molecular information is not well understood. Genetic coding made information useful because it imposed a modular metric on the evolutionary search and thereby offered a general solution to the problem of finding catalysts of any specificity. We use the term "quasispecies symmetry breaking" to describe the iterated process of self-organisation whereby the alphabets of distinguishable codons and amino acids increased, step by step.

Magnetic suspension and balance systems (MSBSs)

NASA Technical Reports Server (NTRS)

Britcher, Colin P.; Kilgore, Robert A.

1987-01-01

The problems of wind tunnel testing are outlined, with attention given to the problems caused by mechanical support systems, such as support interference, dynamic-testing restrictions, and low productivity. The basic principles of magnetic suspension are highlighted, along with the history of magnetic suspension and balance systems. Roll control, size limitations, high angle of attack, reliability, position sensing, and calibration are discussed among the problems and limitations of the existing magnetic suspension and balance systems. Examples of the existing systems are presented, and design studies for future systems are outlined. Problems specific to large-scale magnetic suspension and balance systems, such as high model loads, requirements for high-power electromagnets, high-capacity power supplies, highly sophisticated control systems and position sensors, and high costs are assessed.

Implementation of ISO 10110 optics drawing standards for the National Ignition Facility

NASA Astrophysics Data System (ADS)

Wang, David Y.; English, R. Edward, Jr.; Aikens, David M.

1999-11-01

The National Ignition Facility (NIF) project elected to implement ISO 10110 standard for the specifications of NIF optics drawings in 1996. More than 7,000 NIF large optics and 20,000 NIF small optics will be manufactured based on ISO 10110 indications. ISO 10110 standard meets many of the needs of the NIF optics specifications. It allows the optical engineer to quantify and clearly communicate the desired optical specifications. While no single drawing standard specifies all the requirements of high energy laser system, a combination of ISO 10110 standard with detailed notes make it possible to apply international drawing standards to the NIF laser system. This paper will briefly describe LLNL's interpretation and implementation of the ISO 10110 drawing standard, present some examples of NIF optics drawings, and discuss pros and cons of the indications from the perspective of this application. Emphasis will be given to the surface imperfection specifications, known as 5/, for the NIF optics.

Environmental endocrine disruption: an effects assessment and analysis.

PubMed Central

Crisp, T M; Clegg, E D; Cooper, R L; Wood, W P; Anderson, D G; Baetcke, K P; Hoffmann, J L; Morrow, M S; Rodier, D J; Schaeffer, J E; Touart, L W; Zeeman, M G; Patel, Y M

1998-01-01

This report is an overview of the current state of the science relative to environmental endocrine disruption in humans, laboratory testing, and wildlife species. Background information is presented on the field of endocrinology, the nature of hormones, and potential sites for endocrine disruption, with specific examples of chemicals affecting these sites. An attempt is made to present objectively the issue of endocrine disruption, consider working hypotheses, offer opposing viewpoints, analyze the available information, and provide a reasonable assessment of the problem. Emphasis is placed on disruption of central nervous system--pituitary integration of hormonal and sexual behavioral activity, female and male reproductive system development and function, and thyroid function. In addition, the potential role of environmental endocrine disruption in the induction of breast, testicular, and prostate cancers, as well as endometriosis, is evaluated. The interrelationship of the endocrine and immune system is documented. With respect to endocrine-related ecological effects, specific case examples from the peer-reviewed literature of marine invertebrates and representatives of the five classes of vertebrates are presented and discussed. The report identifies some data gaps in our understanding of the environmental endocrine disruption issue and recommends a few research needs. Finally, the report states the U.S. Environmental Protection Agency Science Policy Council's interim position on endocrine disruption and lists some of the ongoing activities to deal with this matter. PMID:9539004

Expediting analog design retargeting by design knowledge re-use and circuit synthesis: a practical example on a Delta-Sigma modulator

NASA Astrophysics Data System (ADS)

Webb, Matthew; Tang, Hua

2016-08-01

In the past decade or two, due to constant and rapid technology changes, analog design re-use or design retargeting to newer technologies has been brought to the table in order to expedite the design process and improve time-to-market. If properly conducted, analog design retargeting could significantly cut down design cycle compared to designs starting from the scratch. In this article, we present an empirical and general method for efficient analog design retargeting by design knowledge re-use and circuit synthesis (CS). The method first identifies circuit blocks that compose the source system and extracts the performance parameter specifications of each circuit block. Then, for each circuit block, it scales the values of design variables (DV) from the source design to derive an initial design in the target technology. Depending on the performance of this initial target design, a design space is defined for synthesis. Subsequently, each circuit block is automatically synthesised using state-of-art analog synthesis tools based on a combination of global and local optimisation techniques to achieve comparable performance specifications to those extracted from the source system. Finally, the overall system is composed of those synthesised circuit blocks in the target technology. We illustrate the method using a practical example of a complex Delta-Sigma modulator (DSM) circuit.

Wavelet analysis enables system-independent texture analysis of optical coherence tomography images.

PubMed

Lingley-Papadopoulos, Colleen A; Loew, Murray H; Zara, Jason M

2009-01-01

Texture analysis for tissue characterization is a current area of optical coherence tomography (OCT) research. We discuss some of the differences between OCT systems and the effects those differences have on the resulting images and subsequent image analysis. In addition, as an example, two algorithms for the automatic recognition of bladder cancer are compared: one that was developed on a single system with no consideration for system differences, and one that was developed to address the issues associated with system differences. The first algorithm had a sensitivity of 73% and specificity of 69% when tested using leave-one-out cross-validation on data taken from a single system. When tested on images from another system with a different central wavelength, however, the method classified all images as cancerous regardless of the true pathology. By contrast, with the use of wavelet analysis and the removal of system-dependent features, the second algorithm reported sensitivity and specificity values of 87 and 58%, respectively, when trained on images taken with one imaging system and tested on images taken with another.

Wavelet analysis enables system-independent texture analysis of optical coherence tomography images

NASA Astrophysics Data System (ADS)

Lingley-Papadopoulos, Colleen A.; Loew, Murray H.; Zara, Jason M.

2009-07-01

Texture analysis for tissue characterization is a current area of optical coherence tomography (OCT) research. We discuss some of the differences between OCT systems and the effects those differences have on the resulting images and subsequent image analysis. In addition, as an example, two algorithms for the automatic recognition of bladder cancer are compared: one that was developed on a single system with no consideration for system differences, and one that was developed to address the issues associated with system differences. The first algorithm had a sensitivity of 73% and specificity of 69% when tested using leave-one-out cross-validation on data taken from a single system. When tested on images from another system with a different central wavelength, however, the method classified all images as cancerous regardless of the true pathology. By contrast, with the use of wavelet analysis and the removal of system-dependent features, the second algorithm reported sensitivity and specificity values of 87 and 58%, respectively, when trained on images taken with one imaging system and tested on images taken with another.

Exploiting the Multi-Service Domain Protecting Interface

DTIC Science & Technology

2012-10-17

Linux OpenVPN and IPSec VLAN services subsystems. Essentially, MSDPI becomes the transport mechanism for these subsystems. For the RIB, LSP, and...includes those necessary files to build a complete LiveCD system For example, adding various configuration files: ifcfg-eth?, ifcfg-ib?, openvpn ...aka IP address), openvpn files, specific files in the etc/sysconfig directory. %prep %build %install rm -rf $RPM_BUILD_ROOT mkdir -p

Specification and Analysis of Parallel Machine Architecture

DTIC Science & Technology

1990-03-17

Parallel Machine Architeture C.V. Ramamoorthy Computer Science Division Dept. of Electrical Engineering and Computer Science University of California...capacity. (4) Adaptive: The overhead in resolution of deadlocks, etc. should be in proportion to their frequency. (5) Avoid rollbacks: Rollbacks can be...snapshots of system state graphically at a rate proportional to simulation time. Some of the examples are as follow: (1) When the simulation clock of

New approaches for the design and the fabrication of pixelated filters

NASA Astrophysics Data System (ADS)

Lumeau, J.; Lemarquis, F.; Begou, T.; Mathieu, K.; Savin De Larclause, I.; Berthon, J.

2017-09-01

Multispectral or hyperspectral images allow acquiring new information that could not be acquired using colored images and, for example, identifying chemical species on an observed scene using specific highly selective thin film filters. Those images are commonly used in numerous fields, e.g. in agriculture or homeland security and are of prime interest for imaging systems for onboard scientific applications (e.g. for planetology).

Research on Synthesis of Concurrent Computing Systems.

DTIC Science & Technology

1982-09-01

20 1.5.1 An Informal Description of the Techniques ....... ..................... 20 1.5 2 Formal Definitions of Aggregation and Virtualisation ...sparsely interconnected networks . We have also developed techniques to create Kung’s systolic array parallel structure from a specification of matrix...resufts of the computation of that element. For example, if A,j is computed using a single enumeration, then virtualisation would produce a three

Spacecraft high-voltage power supply construction

NASA Technical Reports Server (NTRS)

Sutton, J. F.; Stern, J. E.

1975-01-01

The design techniques, circuit components, fabrication techniques, and past experience used in successful high-voltage power supplies for spacecraft flight systems are described. A discussion of the basic physics of electrical discharges in gases is included and a design rationale for the prevention of electrical discharges is provided. Also included are typical examples of proven spacecraft high-voltage power supplies with typical specifications for design, fabrication, and testing.

Think small - In large numbers. [microspacecraft missions

NASA Technical Reports Server (NTRS)

Jones, Ross M.

1989-01-01

The development and use of microspacecraft are examined. It is proposed that 10-50 microspacecraft per year can be launched; up to 50 microspacecraft can be dispatched with traditional launchers; and 1-3 experiments can be performed on the spacecraft. Various applications for the microspacecraft are discussed and specific examples of proposed missions are presented. Some systems and instruments designed for the microspacecraft are described.

Pharmacokinetic Modeling of JP-8 Jet Fuel Components: II. A Conceptual Framework

DTIC Science & Technology

2003-12-01

example, a single type of (simple) binary interaction between 300 components would require the specification of some 105 interaction coefficients . One...individual substances, via binary mechanisms, is enough to predict the interactions present in the mixture. Secondly, complex mixtures can often be...approximated as pseudo- binary systems, consisting of the compound of interest plus a single interacting complex vehicle with well-defined, composite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piot, P.; Halavanau, A.

This paper discusses the implementation of a python- based high-level interface to the Fermilab acnet control system. The interface has been successfully employed during the commissioning of the Fermilab Accelerator Science & Technology (FAST) facility. Specifically, we present examples of applications at FAST which include the interfacing of the elegant program to assist lattice matching, an automated emittance measurement via the quadrupole-scan method and tranverse transport matrix measurement of a superconducting RF cavity.

Cyber Adversary Dynamics

DTIC Science & Technology

2013-02-01

that the Government formulated or supplied the drawings, specifications, or other data does not license the holder or any other person or corporation ...preparation. Berk , V. H., Cybenko, G., Souza, I. G. D., & Murphy, J. P. (2012, January). “Managing Malicious Insider Risk through BANDIT.” In System... finances , human resources for example; • Tactics – Short term goals and techniques to achieve those goals; • Strategy – Long term outcomes and

Incorporating energy conservation techniques in the operation of existing LeRC R and D facilities. [energy policy/NASA programs

NASA Technical Reports Server (NTRS)

Nieberding, W. C.

1975-01-01

A general discussion of various methods which can be used to reduce energy consumption is presented. A very brief description of Lewis Research Center facilities is given and the energy reduction methods are discussed relative to them. Some specific examples (ie; automated equipment and data systems) of the implementation of the energy reduction methods are included.

Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example.

PubMed

Gunalan, Kabilar; Chaturvedi, Ashutosh; Howell, Bryan; Duchin, Yuval; Lempka, Scott F; Patriat, Remi; Sapiro, Guillermo; Harel, Noam; McIntyre, Cameron C

2017-01-01

Deep brain stimulation (DBS) is an established clinical therapy and computational models have played an important role in advancing the technology. Patient-specific DBS models are now common tools in both academic and industrial research, as well as clinical software systems. However, the exact methodology for creating patient-specific DBS models can vary substantially and important technical details are often missing from published reports. Provide a detailed description of the assembly workflow and parameterization of a patient-specific DBS pathway-activation model (PAM) and predict the response of the hyperdirect pathway to clinical stimulation. Integration of multiple software tools (e.g. COMSOL, MATLAB, FSL, NEURON, Python) enables the creation and visualization of a DBS PAM. An example DBS PAM was developed using 7T magnetic resonance imaging data from a single unilaterally implanted patient with Parkinson's disease (PD). This detailed description implements our best computational practices and most elaborate parameterization steps, as defined from over a decade of technical evolution. Pathway recruitment curves and strength-duration relationships highlight the non-linear response of axons to changes in the DBS parameter settings. Parameterization of patient-specific DBS models can be highly detailed and constrained, thereby providing confidence in the simulation predictions, but at the expense of time demanding technical implementation steps. DBS PAMs represent new tools for investigating possible correlations between brain pathway activation patterns and clinical symptom modulation.

Earthquake ground motion: Chapter 3

USGS Publications Warehouse

Luco, Nicolas; Kircher, Charles A.; Crouse, C. B.; Charney, Finley; Haselton, Curt B.; Baker, Jack W.; Zimmerman, Reid; Hooper, John D.; McVitty, William; Taylor, Andy

2016-01-01

Most of the effort in seismic design of buildings and other structures is focused on structural design. This chapter addresses another key aspect of the design process—characterization of earthquake ground motion into parameters for use in design. Section 3.1 describes the basis of the earthquake ground motion maps in the Provisions and in ASCE 7 (the Standard). Section 3.2 has examples for the determination of ground motion parameters and spectra for use in design. Section 3.3 describes site-specific ground motion requirements and provides example site-specific design and MCER response spectra and example values of site-specific ground motion parameters. Section 3.4 discusses and provides an example for the selection and scaling of ground motion records for use in various types of response history analysis permitted in the Standard.

Evolving Systems: An Outcome of Fondest Hopes and Wildest Dreams

NASA Technical Reports Server (NTRS)

Frost, Susan A.; Balas, Mark J.

2012-01-01

New theory is presented for evolving systems, which are autonomously controlled subsystems that self-assemble into a new evolved system with a higher purpose. Evolving systems of aerospace structures often require additional control when assembling to maintain stability during the entire evolution process. This is the concept of Adaptive Key Component Control that operates through one specific component to maintain stability during the evolution. In addition, this control must often overcome persistent disturbances that occur while the evolution is in progress. Theoretical results will be presented for Adaptive Key Component control for persistent disturbance rejection. An illustrative example will demonstrate the Adaptive Key Component controller on a system composed of rigid body and flexible body modes.

The environmental control and life-support system for a lunar base: What drives its design

NASA Technical Reports Server (NTRS)

Hypes, Warren D.; Hall, John B., Jr.

1992-01-01

The purpose of this paper is to identify and briefly discuss some of the ground rules and mission scenario details that become drivers of the environmental control and life support (ECLS) system design and of the logistics related to the design. This paper is written for mission planners and non-ECLS system engineers to inform them of the details that will be important to the ECLS engineer when the design phase is reached. In addition, examples illustrate the impact of some selected mission characteristics on the logistics associated with ECLS systems. The last section of this paper focuses on the ECLS system technology development sequence and highlights specific portions that need emphasis.

Robustness of Flexible Systems With Component-Level Uncertainties

NASA Technical Reports Server (NTRS)

Maghami, Peiman G.

2000-01-01

Robustness of flexible systems in the presence of model uncertainties at the component level is considered. Specifically, an approach for formulating robustness of flexible systems in the presence of frequency and damping uncertainties at the component level is presented. The synthesis of the components is based on a modifications of a controls-based algorithm for component mode synthesis. The formulation deals first with robustness of synthesized flexible systems. It is then extended to deal with global (non-synthesized ) dynamic models with component-level uncertainties by projecting uncertainties from component levels to system level. A numerical example involving a two-dimensional simulated docking problem is worked out to demonstrate the feasibility of the proposed approach.

Siting Issues for Solar Thermal Power Plants with Small Community Applications

NASA Technical Reports Server (NTRS)

Holbeck, J. J.; Ireland, S. J.

1978-01-01

Technologies for solar thermal plants are being developed to provide energy alternatives for the future. Implementation of these plants requires consideration of siting issues as well as power system technology. While many conventional siting considerations are applicable, there is also a set of unique siting issues for solar thermal plants. Early experimental plants will have special siting considerations. The siting issues associated with small, dispersed solar thermal power plants in the 1 to 10 MWe power range for utility/small community applications are considered. Some specific requirements refer to the first 1 MWe engineering experiment for the Small Power Systems Applications (SPSA) Project. The siting issues themselves are discussed in three categories: (1) system resource requirements, (2) environmental effects on the system, and (3) potential impact of the plant on the environment. Within these categories, specific issues are discussed in a qualitative manner. Examples of limiting factors for some issues are taken from studies of other solar systems.

A Scala DSL for RETE-Based Runtime Verification

NASA Technical Reports Server (NTRS)

Havelund, Klaus

2013-01-01

Runtime verification (RV) consists in part of checking execution traces against formalized specifications. Several systems have emerged, most of which support specification notations based on state machines, regular expressions, temporal logic, or grammars. The field of Artificial Intelligence (AI) has for an even longer period of time studied rule-based production systems, which at a closer look appear to be relevant for RV, although seemingly focused on slightly different application domains, such as for example business processes and expert systems. The core algorithm in many of these systems is the Rete algorithm. We have implemented a Rete-based runtime verification system, named LogFire (originally intended for offline log analysis but also applicable to online analysis), as an internal DSL in the Scala programming language, using Scala's support for defining DSLs. This combination appears attractive from a practical point of view. Our contribution is in part conceptual in arguing that such rule-based frameworks originating from AI may be suited for RV.

Extending the durability of cultivar resistance by limiting epidemic growth rates.

PubMed

Carolan, Kevin; Helps, Joe; van den Berg, Femke; Bain, Ruairidh; Paveley, Neil; van den Bosch, Frank

2017-09-27

Cultivar resistance is an essential part of disease control programmes in many agricultural systems. The use of resistant cultivars applies a selection pressure on pathogen populations for the evolution of virulence, resulting in loss of disease control. Various techniques for the deployment of host resistance genes have been proposed to reduce the selection for virulence, but these are often difficult to apply in practice. We present a general technique to maintain the effectiveness of cultivar resistance. Derived from classical population genetics theory; any factor that reduces the population growth rates of both the virulent and avirulent strains will reduce selection. We model the specific example of fungicide application to reduce the growth rates of virulent and avirulent strains of a pathogen, demonstrating that appropriate use of fungicides reduces selection for virulence, prolonging cultivar resistance. This specific example of chemical control illustrates a general principle for the development of techniques to manage the evolution of virulence by slowing epidemic growth rates. © 2017 The Author(s).

The role of central noradrenergic dysregulation in anxiety disorders: evidence from clinical studies.

PubMed

Kalk, N J; Nutt, D J; Lingford-Hughes, A R

2011-01-01

The nature of the noradrenergic dysregulation in clinical anxiety disorders remains unclear. In panic disorder, the predominant view has been that central noradrenergic neuronal networks and/or the sympathetic nervous system was normal in patients at rest, but hyper-reactive to specific stimuli, for example carbon dioxide. These ideas have been extended to other anxiety disorders, which share with panic disorder characteristic subjective anxiety and physiological symptoms of excess sympathetic activity. For example, Generalized Anxiety Disorder is characterized by chronic free-floating anxiety, muscle tension, palpitation and insomnia. It has been proposed that there is chronic central hypersecretion of noradrenaline in Generalized Anxiety Disorder, with consequent hyporesponsiveness of central post-synaptic receptors. With regards to other disorders, it has been suggested that there is noradrenergic involvement or derangement, but a more specific hypothesis has not been enunciated. This paper reviews the evidence for noradrenergic dysfunction in anxiety disorders, derived from indirect measures of noradrenergic function in clinical populations.

Importance of public relations in recycling strategies: principles and case studies.

PubMed

Salhofer, Stefan; Isaac, Nicole A

2002-07-01

The separate collection of waste, and especially of recyclables with specific collection systems, would not be possible without the involvement of the users. Apart from the physical installations such as collection containers, collection points, etc., the motivation of the users is an essential component. Motivation can be reinforced through public relations work. In addition to the underlying technical considerations, this paper describes the difference between communication in general and public relations and specifically examines public involvement in recycling. Through the use of examples, we look at the targeted users and typical media employed. Furthermore, we analyzes the development of public involvement. The examples show that public relations for recycling strategies relies to a great extent on attitudes, habits, and access to the target group. Thus, standardized procedures cannot be developed. For these reasons, public relation activities must be planned carefully and professionally and include an analysis of the target group, choice of media, and verification of success.

Application of parameter estimation to aircraft stability and control: The output-error approach

NASA Technical Reports Server (NTRS)

Maine, Richard E.; Iliff, Kenneth W.

1986-01-01

The practical application of parameter estimation methodology to the problem of estimating aircraft stability and control derivatives from flight test data is examined. The primary purpose of the document is to present a comprehensive and unified picture of the entire parameter estimation process and its integration into a flight test program. The document concentrates on the output-error method to provide a focus for detailed examination and to allow us to give specific examples of situations that have arisen. The document first derives the aircraft equations of motion in a form suitable for application to estimation of stability and control derivatives. It then discusses the issues that arise in adapting the equations to the limitations of analysis programs, using a specific program for an example. The roles and issues relating to mass distribution data, preflight predictions, maneuver design, flight scheduling, instrumentation sensors, data acquisition systems, and data processing are then addressed. Finally, the document discusses evaluation and the use of the analysis results.

Generic Airplane Model Concept and Four Specific Models Developed for Use in Piloted Simulation Studies

NASA Technical Reports Server (NTRS)

Hoffler, Keith D.; Fears, Scott P.; Carzoo, Susan W.

1997-01-01

A generic airplane model concept was developed to allow configurations with various agility, performance, handling qualities, and pilot vehicle interface to be generated rapidly for piloted simulation studies. The simple concept allows stick shaping and various stick command types or modes to drive an airplane with both linear and nonlinear components. Output from the stick shaping goes to linear models or a series of linear models that can represent an entire flight envelope. The generic model also has provisions for control power limitations, a nonlinear feature. Therefore, departures from controlled flight are possible. Note that only loss of control is modeled, the generic airplane does not accurately model post departure phenomenon. The model concept is presented herein, along with four example airplanes. Agility was varied across the four example airplanes without altering specific excess energy or significantly altering handling qualities. A new feedback scheme to provide angle-of-attack cueing to the pilot, while using a pitch rate command system, was implemented and tested.

Standby power generation under utility curtailment contract agreements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nolan, G.J.; Puccio, V.J.; Calhoun, C.W.

1995-12-31

Many utilities in the US offer large industrial and commercial customers power sales contracts which have attractive rates under a curtailment requirement. This curtailment requirement allows the utility to require the customer to reduce its power demand to a predetermined level within a specific time period. If the required curtailment is not achieved by the customer within the allocated time period, stiff financial penalties are usually enforced by the utility. The attractiveness of the contract rates usually is proportional to the amount of curtailment required. To take advantage of these attractive rates, a customer must be able to withstand themore » curtailment without supplemental generation or must add standby generation to meet its needs. Obviously, the cost of the curtailments to the customer should not exceed the economic benefits of reduced rates. This paper reviews the alternatives faced by a curtailment contract customer together with potential load shedding and standby generation system designs. An example of implementing a curtailment contract at an existing industrial facility is presented. The example facility, Boeing Helicopters of Philadelphia, Pennsylvania required both load shedding and standby generation. The load shedding scheme is fairly complex and is controlled by a programmable logic controller (PLC). The standby generation and load shedding systems for the example facility are examined in detail. Also, lessons learned from implementing the required modifications to the example facility are discussed.« less

Application of Artificial Intelligence technology to the analysis and synthesis of reliable software systems

NASA Technical Reports Server (NTRS)

Wild, Christian; Eckhardt, Dave

1987-01-01

The development of a methodology for the production of highly reliable software is one of the greatest challenges facing the computer industry. Meeting this challenge will undoubtably involve the integration of many technologies. This paper describes the use of Artificial Intelligence technologies in the automated analysis of the formal algebraic specifications of abstract data types. These technologies include symbolic execution of specifications using techniques of automated deduction and machine learning through the use of examples. On-going research into the role of knowledge representation and problem solving in the process of developing software is also discussed.

Hadl: HUMS Architectural Description Language

NASA Technical Reports Server (NTRS)

Mukkamala, R.; Adavi, V.; Agarwal, N.; Gullapalli, S.; Kumar, P.; Sundaram, P.

2004-01-01

Specification of architectures is an important prerequisite for evaluation of architectures. With the increase m the growth of health usage and monitoring systems (HUMS) in commercial and military domains, the need far the design and evaluation of HUMS architectures has also been on the increase. In this paper, we describe HADL, HUMS Architectural Description Language, that we have designed for this purpose. In particular, we describe the features of the language, illustrate them with examples, and show how we use it in designing domain-specific HUMS architectures. A companion paper contains details on our design methodology of HUMS architectures.

Organization of supercoil domains and their reorganization by transcription

PubMed Central

Deng, Shuang; Stein, Richard A.; Higgins, N. Patrick

2006-01-01

Summary During a normal cell cycle, chromosomes are exposed to many biochemical reactions that require specific types of DNA movement. Separation forces move replicated chromosomes into separate sister cell compartments during cell division, and the contemporaneous acts of DNA replication, RNA transcription and cotranscriptional translation of membrane proteins cause specific regions of DNA to twist, writhe and expand or contract. Recent experiments indicate that a dynamic and stochastic mechanism creates supercoil DNA domains soon after DNA replication. Domain structure is subsequently reorganized by RNA transcription. Examples of transcription-dependent chromosome remodelling are also emerging from eukaryotic cell systems. PMID:16135220

Computer calculation of device, circuit, equipment, and system reliability.

NASA Technical Reports Server (NTRS)

Crosby, D. R.

1972-01-01

A grouping into four classes is proposed for all reliability computations that are related to electronic equipment. Examples are presented of reliability computations in three of these four classes. Each of the three specific reliability tasks described was originally undertaken to satisfy an engineering need for reliability data. The form and interpretation of the print-out of the specific reliability computations is presented. The justification for the costs of these computations is indicated. The skills of the personnel used to conduct the analysis, the interfaces between the personnel, and the timing of the projects is discussed.

Fractal attractors and singular invariant measures in two-sector growth models with random factor shares

NASA Astrophysics Data System (ADS)

La Torre, Davide; Marsiglio, Simone; Mendivil, Franklin; Privileggi, Fabio

2018-05-01

We analyze a multi-sector growth model subject to random shocks affecting the two sector-specific production functions twofold: the evolution of both productivity and factor shares is the result of such exogenous shocks. We determine the optimal dynamics via Euler-Lagrange equations, and show how these dynamics can be described in terms of an iterated function system with probability. We also provide conditions that imply the singularity of the invariant measure associated with the fractal attractor. Numerical examples show how specific parameter configurations might generate distorted copies of the Barnsley's fern attractor.

Fast and Accurate Exhaled Breath Ammonia Measurement

PubMed Central

Solga, Steven F.; Mudalel, Matthew L.; Spacek, Lisa A.; Risby, Terence H.

2014-01-01

This exhaled breath ammonia method uses a fast and highly sensitive spectroscopic method known as quartz enhanced photoacoustic spectroscopy (QEPAS) that uses a quantum cascade based laser. The monitor is coupled to a sampler that measures mouth pressure and carbon dioxide. The system is temperature controlled and specifically designed to address the reactivity of this compound. The sampler provides immediate feedback to the subject and the technician on the quality of the breath effort. Together with the quick response time of the monitor, this system is capable of accurately measuring exhaled breath ammonia representative of deep lung systemic levels. Because the system is easy to use and produces real time results, it has enabled experiments to identify factors that influence measurements. For example, mouth rinse and oral pH reproducibly and significantly affect results and therefore must be controlled. Temperature and mode of breathing are other examples. As our understanding of these factors evolves, error is reduced, and clinical studies become more meaningful. This system is very reliable and individual measurements are inexpensive. The sampler is relatively inexpensive and quite portable, but the monitor is neither. This limits options for some clinical studies and provides rational for future innovations. PMID:24962141

Information System Engineering Supporting Observation, Orientation, Decision, and Compliant Action

NASA Astrophysics Data System (ADS)

Georgakopoulos, Dimitrios

The majority of today's software systems and organizational/business structures have been built on the foundation of solving problems via long-term data collection, analysis, and solution design. This traditional approach of solving problems and building corresponding software systems and business processes, falls short in providing the necessary solutions needed to deal with many problems that require agility as the main ingredient of their solution. For example, such agility is needed in responding to an emergency, in military command control, physical security, price-based competition in business, investing in the stock market, video gaming, network monitoring and self-healing, diagnosis in emergency health care, and many other areas that are too numerous to list here. The concept of Observe, Orient, Decide, and Act (OODA) loops is a guiding principal that captures the fundamental issues and approach for engineering information systems that deal with many of these problem areas. However, there are currently few software systems that are capable of supporting OODA. In this talk, we provide a tour of the research issues and state of the art solutions for supporting OODA. In addition, we provide specific examples of OODA solutions we have developed for the video surveillance and emergency response domains.

Neural processing, perception, and behavioral responses to natural chemical stimuli by fish and crustaceans.

PubMed

Derby, Charles D; Sorensen, Peter W

2008-07-01

This manuscript reviews the chemical ecology of two of the major aquatic animal models, fish and crustaceans, in the study of chemoreception. By necessity, it is restricted in scope, with most emphasis placed on teleost fish and decapod crustaceans. First, we describe the nature of the chemical world perceived by fish and crustaceans, giving examples of the abilities of these animals to analyze complex natural odors. Fish and crustaceans share the same environments and have evolved some similar chemosensory features: the ability to detect and discern mixtures of small metabolites in highly variable backgrounds and to use this information to identify food, mates, predators, and habitat. Next, we give examples of the molecular nature of some of these natural products, including a description of methodologies used to identify them. Both fish and crustaceans use their olfactory and gustatory systems to detect amino acids, amines, and nucleotides, among many other compounds, while fish olfactory systems also detect mixtures of sex steroids and prostaglandins with high specificity and sensitivity. Third, we discuss the importance of plasticity in chemical sensing by fish and crustaceans. Finally, we conclude with a description of how natural chemical stimuli are processed by chemosensory systems. In both fishes and crustaceans, the olfactory system is especially adept at mixture discrimination, while gustation is well suited to facilitate precise localization and ingestion of food. The behaviors of both fish and crustaceans can be defined by the chemical worlds in which they live and the abilities of their nervous systems to detect and identify specific features in their domains. An understanding of these worlds and the sensory systems that provide the animals with information about them provides insight into the chemical ecology of these species.

E-ELT requirements flow down

NASA Astrophysics Data System (ADS)

Gonzalez, J. C.; Kurlandczyk, H.; Schmid, C.; Schneller, D.

2016-08-01

One of the critical activities in the systems engineering scope of work is managing requirements. In line with this, E-ELT devotes a significant effort to this activity, which follows a well-established process. This involves optimally deriving requirements from the user (Top-Level Requirements) through the system Level 1 Requirements and from here down to subsystems procurement specifications. This paper describes the process, which is illustrated with some practical examples, including in particular the role of technical budgets to derive requirements on subsystems. Also, the provisions taken for the requirements verification are discussed.

An improved NSGA - II algorithm for mixed model assembly line balancing

NASA Astrophysics Data System (ADS)

Wu, Yongming; Xu, Yanxia; Luo, Lifei; Zhang, Han; Zhao, Xudong

2018-05-01

Aiming at the problems of assembly line balancing and path optimization for material vehicles in mixed model manufacturing system, a multi-objective mixed model assembly line (MMAL), which is based on optimization objectives, influencing factors and constraints, is established. According to the specific situation, an improved NSGA-II algorithm based on ecological evolution strategy is designed. An environment self-detecting operator, which is used to detect whether the environment changes, is adopted in the algorithm. Finally, the effectiveness of proposed model and algorithm is verified by examples in a concrete mixing system.

Improved sensitivity high-definition interline CCD using the KODAK TRUESENSE color filter pattern

NASA Astrophysics Data System (ADS)

DiBella, James; Andreghetti, Marco; Enge, Amy; Chen, William; Stanka, Timothy; Kaser, Robert

2010-01-01

The KODAK TRUESENSE Color Filter Pattern has technology that for the first time is applied to a commercially available interline CCD. This 2/3" true-HD sensor will be described along with its performance attributes, including sensitivity improvement as compared to the Bayer CFA version of the same sensor. In addition, an overview of the system developed for demonstration and evaluation will be provided. Examples of the benefits of the new technology in specific applications including surveillance and intelligent traffic systems will be discussed.

AAAI (American Association on Artificial Intelligence) Workshop on AI (Artificial Intelligence) Simulation Held in Philadelphia, Pennsylvania on August 11, 1986,

DTIC Science & Technology

1986-08-01

is then applied in i ABSTRCT : ,.:,.vu knowledge acquisition from those multiple sources for a specific design, for example, an expert system for...67. N 181.1 47.U3 a75 269;9.6 % A. %3 3 Genetic Explanations: For the concept of a genetic explanation (see .d -. above) to apply to the Gaither...Simulation Research Unit (Acock,1985; Baker,1983; Baker,1985). -. MD’,EX srves as an inner shell for apPlying Artificial Intelligence and E:pert System

The QED engine spectrum - Fusion-electric propulsion for air-breathing to interstellar flight

NASA Technical Reports Server (NTRS)

Bussard, Robert W.; Jameson, Lorin W.

1993-01-01

A new inertial-electrostatic-fusion direct electric power source can be used to drive a relativistic e-beam to heat propellant. The resulting system is shown to yield specific impulse and thrust/mass ratio 2-3 orders of magnitude larger than from other advanced propulsion concepts. This QED system can be applied to aerospace vehicles from air-breathing to near-interstellar flight. Examples are given for Earth/Mars flight missions, that show transit times of 40 d with 20 percent payload in single-stage vehicles.

Pathology report data extraction from relational database using R, with extraction from reports on melanoma of skin as an example.

PubMed

Ye, Jay J

2016-01-01

Different methods have been described for data extraction from pathology reports with varying degrees of success. Here a technique for directly extracting data from relational database is described. Our department uses synoptic reports modified from College of American Pathologists (CAP) Cancer Protocol Templates to report most of our cancer diagnoses. Choosing the melanoma of skin synoptic report as an example, R scripting language extended with RODBC package was used to query the pathology information system database. Reports containing melanoma of skin synoptic report in the past 4 and a half years were retrieved and individual data elements were extracted. Using the retrieved list of the cases, the database was queried a second time to retrieve/extract the lymph node staging information in the subsequent reports from the same patients. 426 synoptic reports corresponding to unique lesions of melanoma of skin were retrieved, and data elements of interest were extracted into an R data frame. The distribution of Breslow depth of melanomas grouped by year is used as an example of intra-report data extraction and analysis. When the new pN staging information was present in the subsequent reports, 82% (77/94) was precisely retrieved (pN0, pN1, pN2 and pN3). Additional 15% (14/94) was retrieved with certain ambiguity (positive or knowing there was an update). The specificity was 100% for both. The relationship between Breslow depth and lymph node status was graphed as an example of lesion-specific multi-report data extraction and analysis. R extended with RODBC package is a simple and versatile approach well-suited for the above tasks. The success or failure of the retrieval and extraction depended largely on whether the reports were formatted and whether the contents of the elements were consistently phrased. This approach can be easily modified and adopted for other pathology information systems that use relational database for data management.

Investigation of Metal Oxide/Carbon Nano Material as Anode for High Capacity Lithium-ion Cells

NASA Technical Reports Server (NTRS)

Wu, James Jianjun; Hong, Haiping

2014-01-01

NASA is developing high specific energy and high specific capacity lithium-ion battery (LIB) technology for future NASA missions. Current state-of-art LIBs have issues in terms of safety and thermal stability, and are reaching limits in specific energy capability based on the electrochemical materials selected. For example, the graphite anode has a limited capability to store Li since the theoretical capacity of graphite is 372 mAh/g. To achieve higher specific capacity and energy density, and to improve safety for current LIBs, alternative advanced anode, cathode, and electrolyte materials are pursued under the NASA Advanced Space Power System Project. In this study, the nanostructed metal oxide, such as Fe2O3 on carbon nanotubes (CNT) composite as an LIB anode has been investigated.

Enhanced optical design by distortion control

NASA Astrophysics Data System (ADS)

Thibault, Simon; Gauvin, Jonny; Doucet, Michel; Wang, Min

2005-09-01

The control of optical distortion is useful for the design of a variety of optical system. The most popular is the F-theta lens used in laser scanning system to produce a constant scan velocity across the image plane. Many authors have designed during the last 20 years distortion control corrector. Today, many challenging digital imaging system can use distortion the enhanced their imaging capability. A well know example is a reversed telephoto type, if the barrel distortion is increased instead of being corrected; the result is a so-called Fish-eye lens. However, if we control the barrel distortion instead of only increasing it, the resulting system can have enhanced imaging capability. This paper will present some lens design and real system examples that clearly demonstrate how the distortion control can improve the system performances such as resolution. We present innovative optical system which increases the resolution in the field of view of interest to meet the needs of specific applications. One critical issue when we designed using distortion is the optimization management. Like most challenging lens design, the automatic optimization is less reliable. Proper management keeps the lens design within the correct range, which is critical for optimal performance (size, cost, manufacturability). Many lens design presented tailor a custom merit function and approach.

Sharing clinical information across care settings: the birth of an integrated assessment system

PubMed Central

Gray, Leonard C; Berg, Katherine; Fries, Brant E; Henrard, Jean-Claude; Hirdes, John P; Steel, Knight; Morris, John N

2009-01-01

Background Population ageing, the emergence of chronic illness, and the shift away from institutional care challenge conventional approaches to assessment systems which traditionally are problem and setting specific. Methods From 2002, the interRAI research collaborative undertook development of a suite of assessment tools to support assessment and care planning of persons with chronic illness, frailty, disability, or mental health problems across care settings. The suite constitutes an early example of a "third generation" assessment system. Results The rationale and development strategy for the suite is described, together with a description of potential applications. To date, ten instruments comprise the suite, each comprising "core" items shared among the majority of instruments and "optional" items that are specific to particular care settings or situations. Conclusion This comprehensive suite offers the opportunity for integrated multi-domain assessment, enabling electronic clinical records, data transfer, ease of interpretation and streamlined training. PMID:19402891

Smart Electrospun Nanofibers for Controlled Drug Release: Recent Advances and New Perspectives

PubMed Central

Weng, Lin; Xie, Jingwei

2017-01-01

In biological systems, chemical molecules or ions often release upon certain conditions, at a specific location, and over a desired period of time. Electrospun nanofibers that undergo alterations in the physicochemical characteristics corresponding to environmental changes have gained considerable interest for various applications. Inspired by biological systems, therapeutic molecules have been integrated with these smart electrospun nanofibers, presenting activation-modulated or feedback-regulated control of drug release. Compared to other materials like smart hydrogels, environment-responsive nanofiber-based drug delivery systems are relatively new but possess incomparable advantages due to their greater permeability, which allows shorter response time and more precise control over the release rate. In this article, we review the mechanisms of various environmental parameters functioning as stimuli to tailor the release rates of smart electrospun nanofibers. We also illustrate several typical examples in specific applications. We conclude this article with a discussion on perspectives and future possibilities in this field. PMID:25732665

Smart electrospun nanofibers for controlled drug release: recent advances and new perspectives.

PubMed

Weng, Lin; Xie, Jingwei

2015-01-01

In biological systems, chemical molecules or ions often release upon certain conditions, at a specific location, and over a desired period of time. Electrospun nanofibers that undergo alterations in the physicochemical characteristics corresponding to environmental changes have gained considerable interest for various applications. Inspired by biological systems, therapeutic molecules have been integrated with these smart electrospun nanofibers, presenting activation-modulated or feedback-regulated control of drug release. Compared to other materials like smart hydrogels, environment-responsive nanofiber-based drug delivery systems are relatively new but possess incomparable advantages due to their greater permeability, which allows shorter response time and more precise control over the release rate. In this article, we review the mechanisms of various environmental parameters functioning as stimuli to tailor the release rates of smart electrospun nanofibers. We also illustrate several typical examples in specific applications. We conclude this article with a discussion on perspectives and future possibilities in this field.

A hierarchical approach to reliability modeling of fault-tolerant systems. M.S. Thesis

NASA Technical Reports Server (NTRS)

Gossman, W. E.

1986-01-01

A methodology for performing fault tolerant system reliability analysis is presented. The method decomposes a system into its subsystems, evaluates vent rates derived from the subsystem's conditional state probability vector and incorporates those results into a hierarchical Markov model of the system. This is done in a manner that addresses failure sequence dependence associated with the system's redundancy management strategy. The method is derived for application to a specific system definition. Results are presented that compare the hierarchical model's unreliability prediction to that of a more complicated tandard Markov model of the system. The results for the example given indicate that the hierarchical method predicts system unreliability to a desirable level of accuracy while achieving significant computational savings relative to component level Markov model of the system.

Decision Support System Requirements Definition for Human Extravehicular Activity Based on Cognitive Work Analysis

PubMed Central

Miller, Matthew James; McGuire, Kerry M.; Feigh, Karen M.

2016-01-01

The design and adoption of decision support systems within complex work domains is a challenge for cognitive systems engineering (CSE) practitioners, particularly at the onset of project development. This article presents an example of applying CSE techniques to derive design requirements compatible with traditional systems engineering to guide decision support system development. Specifically, it demonstrates the requirements derivation process based on cognitive work analysis for a subset of human spaceflight operations known as extravehicular activity. The results are presented in two phases. First, a work domain analysis revealed a comprehensive set of work functions and constraints that exist in the extravehicular activity work domain. Second, a control task analysis was performed on a subset of the work functions identified by the work domain analysis to articulate the translation of subject matter states of knowledge to high-level decision support system requirements. This work emphasizes an incremental requirements specification process as a critical component of CSE analyses to better situate CSE perspectives within the early phases of traditional systems engineering design. PMID:28491008

Decision Support System Requirements Definition for Human Extravehicular Activity Based on Cognitive Work Analysis.

PubMed

Miller, Matthew James; McGuire, Kerry M; Feigh, Karen M

2017-06-01

The design and adoption of decision support systems within complex work domains is a challenge for cognitive systems engineering (CSE) practitioners, particularly at the onset of project development. This article presents an example of applying CSE techniques to derive design requirements compatible with traditional systems engineering to guide decision support system development. Specifically, it demonstrates the requirements derivation process based on cognitive work analysis for a subset of human spaceflight operations known as extravehicular activity . The results are presented in two phases. First, a work domain analysis revealed a comprehensive set of work functions and constraints that exist in the extravehicular activity work domain. Second, a control task analysis was performed on a subset of the work functions identified by the work domain analysis to articulate the translation of subject matter states of knowledge to high-level decision support system requirements. This work emphasizes an incremental requirements specification process as a critical component of CSE analyses to better situate CSE perspectives within the early phases of traditional systems engineering design.

Nonlinear quantum Langevin equations for bosonic modes in solid-state systems

NASA Astrophysics Data System (ADS)

Manninen, Juuso; Agasti, Souvik; Massel, Francesco

2017-12-01

Based on the experimental evidence that impurities contribute to the dissipation properties of solid-state open quantum systems, we provide here a description in terms of nonlinear quantum Langevin equations of the role played by two-level systems in the dynamics of a bosonic degree of freedom. Our starting point is represented by the description of the system-environment coupling in terms of coupling to two separate reservoirs, modeling the interaction with external bosonic modes and two-level systems, respectively. Furthermore, we show how this model represents a specific example of a class of open quantum systems that can be described by nonlinear quantum Langevin equations. Our analysis offers a potential explanation of the parametric effects recently observed in circuit-QED cavity optomechanics experiments.

13 CFR 121.1007 - Must a protest of size status relate to a particular procurement and be specific?

Code of Federal Regulations, 2011 CFR

2011-01-01

... contracts in excess of $5 million last year is sufficiently specific. [61 FR 3286, Jan. 31, 1996, as amended... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Must a protest of size status... following are examples of allegation specificity: Example 1: An allegation that concern X is large because...

13 CFR 121.1007 - Must a protest of size status relate to a particular procurement and be specific?

Code of Federal Regulations, 2013 CFR

2013-01-01

... contracts in excess of $5 million last year is sufficiently specific. [61 FR 3286, Jan. 31, 1996, as amended... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Must a protest of size status... following are examples of allegation specificity: Example 1: An allegation that concern X is large because...

13 CFR 121.1007 - Must a protest of size status relate to a particular procurement and be specific?

Code of Federal Regulations, 2014 CFR

2014-01-01

... contracts in excess of $5 million last year is sufficiently specific. [61 FR 3286, Jan. 31, 1996, as amended... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Must a protest of size status... following are examples of allegation specificity: Example 1: An allegation that concern X is large because...

13 CFR 121.1007 - Must a protest of size status relate to a particular procurement and be specific?

Code of Federal Regulations, 2012 CFR

2012-01-01

... contracts in excess of $5 million last year is sufficiently specific. [61 FR 3286, Jan. 31, 1996, as amended... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Must a protest of size status... following are examples of allegation specificity: Example 1: An allegation that concern X is large because...

13 CFR 121.1007 - Must a protest of size status relate to a particular procurement and be specific?

Code of Federal Regulations, 2010 CFR

2010-01-01

... contracts in excess of $5 million last year is sufficiently specific. [61 FR 3286, Jan. 31, 1996, as amended... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Must a protest of size status... following are examples of allegation specificity: Example 1: An allegation that concern X is large because...

Verification of Space Station Secondary Power System Stability Using Design of Experiment

NASA Technical Reports Server (NTRS)

Karimi, Kamiar J.; Booker, Andrew J.; Mong, Alvin C.; Manners, Bruce

1998-01-01

This paper describes analytical methods used in verification of large DC power systems with applications to the International Space Station (ISS). Large DC power systems contain many switching power converters with negative resistor characteristics. The ISS power system presents numerous challenges with respect to system stability such as complex sources and undefined loads. The Space Station program has developed impedance specifications for sources and loads. The overall approach to system stability consists of specific hardware requirements coupled with extensive system analysis and testing. Testing of large complex distributed power systems is not practical due to size and complexity of the system. Computer modeling has been extensively used to develop hardware specifications as well as to identify system configurations for lab testing. The statistical method of Design of Experiments (DoE) is used as an analysis tool for verification of these large systems. DOE reduces the number of computer runs which are necessary to analyze the performance of a complex power system consisting of hundreds of DC/DC converters. DoE also provides valuable information about the effect of changes in system parameters on the performance of the system. DoE provides information about various operating scenarios and identification of the ones with potential for instability. In this paper we will describe how we have used computer modeling to analyze a large DC power system. A brief description of DoE is given. Examples using applications of DoE to analysis and verification of the ISS power system are provided.

48 CFR 225.504 - Evaluation examples.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Evaluation examples. 225.504 Section 225.504 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... 225.504 Evaluation examples. For examples that illustrate the evaluation procedures in 225.502(c)(ii...

Variable dual-frequency electrostatic wave launcher for plasma applications.

PubMed

Jorns, Benjamin; Sorenson, Robert; Choueiri, Edgar

2011-12-01

A variable tuning system is presented for launching two electrostatic waves concurrently in a magnetized plasma. The purpose of this system is to satisfy the wave launching requirements for plasma applications where maximal power must be coupled into two carefully tuned electrostatic waves while minimizing erosion to the launching antenna. Two parallel LC traps with fixed inductors and variable capacitors are used to provide an impedance match between a two-wave source and a loop antenna placed outside the plasma. Equivalent circuit analysis is then employed to derive an analytical expression for the normalized, average magnetic flux density produced by the antenna in this system as a function of capacitance and frequency. It is found with this metric that the wave launcher can couple to electrostatic modes at two variable frequencies concurrently while attenuating noise from the source signal at undesired frequencies. An example based on an experiment for plasma heating with two electrostatic waves is used to demonstrate a procedure for tailoring the wave launcher to accommodate the frequency range and flux densities of a specific two-wave application. This example is also used to illustrate a method based on averaging over wave frequencies for evaluating the overall efficacy of the system. The wave launcher is shown to be particularly effective for the illustrative example--generating magnetic flux densities in excess of 50% of the ideal case at two variable frequencies concurrently--with a high adaptability to a number of plasma dynamics and heating applications.

Biological Movement and Laws of Physics.

PubMed

Latash, Mark L

2017-07-01

Living systems may be defined as systems able to organize new, biology-specific, laws of physics and modify their parameters for specific tasks. Examples include the force-length muscle dependence mediated by the stretch reflex, and the control of movements with modification of the spatial referent coordinates for salient performance variables. Low-dimensional sets of referent coordinates at a task level are transformed to higher-dimensional sets at lower hierarchical levels in a way that ensures stability of performance. Stability of actions can be controlled independently of the actions (e.g., anticipatory synergy adjustments). Unintentional actions reflect relaxation processes leading to drifts of corresponding referent coordinates in the absence of changes in external load. Implications of this general framework for movement disorders, motor development, motor skill acquisition, and even philosophy are discussed.

A Nuclear Cryogenic Propulsion Stage for Near-Term Space Missions

NASA Technical Reports Server (NTRS)

Houts, Michael G.; Kim, Tony; Emrich, William J.; Hickman, Robert R.; Broadway, Jeramie W.; Gerrish, Harold P.; Adams, Robert B.; Bechtel, Ryan D.; Borowski, Stanley K.; George, Jeffrey A.

2013-01-01

Development efforts in the United States have demonstrated the viability and performance potential of NTP systems. For example, Project Rover (1955 - 1973) completed 22 high power rocket reactor tests. Peak performances included operating at an average hydrogen exhaust temperature of 2550 K and a peak fuel power density of 5200 MW/m3 (Pewee test), operating at a thrust of 930 kN (Phoebus-2A test), and operating for 62.7 minutes on a single burn (NRXA6 test). Results from Project Rover indicated that an NTP system with a high thrust-toweight ratio and a specific impulse greater than 900 s would be feasible. Excellent results have also been obtained by Russia. Ternary carbide fuels developed in Russia may have the potential for providing even higher specific impulses.

Application of nanomaterials in the bioanalytical detection of disease-related genes.

PubMed

Zhu, Xiaoqian; Li, Jiao; He, Hanping; Huang, Min; Zhang, Xiuhua; Wang, Shengfu

2015-12-15

In the diagnosis of genetic diseases and disorders, nanomaterials-based gene detection systems have significant advantages over conventional diagnostic systems in terms of simplicity, sensitivity, specificity, and portability. In this review, we describe the application of nanomaterials for disease-related genes detection in different methods excluding PCR-related method, such as colorimetry, fluorescence-based methods, electrochemistry, microarray methods, surface-enhanced Raman spectroscopy (SERS), quartz crystal microbalance (QCM) methods, and dynamic light scattering (DLS). The most commonly used nanomaterials are gold, silver, carbon and semiconducting nanoparticles. Various nanomaterials-based gene detection methods are introduced, their respective advantages are discussed, and selected examples are provided to illustrate the properties of these nanomaterials and their emerging applications for the detection of specific nucleic acid sequences. Copyright © 2015. Published by Elsevier B.V.

Hitting the sweet spot-glycans as targets of fungal defense effector proteins.

PubMed

Künzler, Markus

2015-05-06

Organisms which rely solely on innate defense systems must combat a large number of antagonists with a comparably low number of defense effector molecules. As one solution of this problem, these organisms have evolved effector molecules targeting epitopes that are conserved between different antagonists of a specific taxon or, if possible, even of different taxa. In order to restrict the activity of the defense effector molecules to physiologically relevant taxa, these target epitopes should, on the other hand, be taxon-specific and easily accessible. Glycans fulfill all these requirements and are therefore a preferred target of defense effector molecules, in particular defense proteins. Here, we review this defense strategy using the example of the defense system of multicellular (filamentous) fungi against microbial competitors and animal predators.

Physiologically relevant organs on chips.

PubMed

Yum, Kyungsuk; Hong, Soon Gweon; Healy, Kevin E; Lee, Luke P

2014-01-01

Recent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine and pharmaceutical research. Here we review the recent development of microengineered physiological systems, or also known as "ogans-on-chips", that reconstitute the physiologically critical features of specific human tissues and organs and their interactions. This technology uses microengineering approaches to construct organ-specific microenvironments, reconstituting tissue structures, tissue-tissue interactions and interfaces, and dynamic mechanical and biochemical stimuli found in specific organs, to direct cells to assemble into functional tissues. We first discuss microengineering approaches to reproduce the key elements of physiologically important, dynamic mechanical microenvironments, biochemical microenvironments, and microarchitectures of specific tissues and organs in microfluidic cell culture systems. This is followed by examples of microengineered individual organ models that incorporate the key elements of physiological microenvironments into single microfluidic cell culture systems to reproduce organ-level functions. Finally, microengineered multiple organ systems that simulate multiple organ interactions to better represent human physiology, including human responses to drugs, is covered in this review. This emerging organs-on-chips technology has the potential to become an alternative to 2D and 3D cell culture and animal models for experimental medicine, human disease modeling, drug development, and toxicology. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

iTesla Power Systems Library (iPSL): A Modelica library for phasor time-domain simulations

NASA Astrophysics Data System (ADS)

Vanfretti, L.; Rabuzin, T.; Baudette, M.; Murad, M.

The iTesla Power Systems Library (iPSL) is a Modelica package providing a set of power system components for phasor time-domain modeling and simulation. The Modelica language provides a systematic approach to develop models using a formal mathematical description, that uniquely specifies the physical behavior of a component or the entire system. Furthermore, the standardized specification of the Modelica language (Modelica Association [1]) enables unambiguous model exchange by allowing any Modelica-compliant tool to utilize the models for simulation and their analyses without the need of a specific model transformation tool. As the Modelica language is being developed with open specifications, any tool that implements these requirements can be utilized. This gives users the freedom of choosing an Integrated Development Environment (IDE) of their choice. Furthermore, any integration solver can be implemented within a Modelica tool to simulate Modelica models. Additionally, Modelica is an object-oriented language, enabling code factorization and model re-use to improve the readability of a library by structuring it with object-oriented hierarchy. The developed library is released under an open source license to enable a wider distribution and let the user customize it to their specific needs. This paper describes the iPSL and provides illustrative application examples.

An Object-Based Approach to Evaluation of Climate Variability Projections and Predictions

NASA Astrophysics Data System (ADS)

Ammann, C. M.; Brown, B.; Kalb, C. P.; Bullock, R.

2017-12-01

Evaluations of the performance of earth system model predictions and projections are of critical importance to enhance usefulness of these products. Such evaluations need to address specific concerns depending on the system and decisions of interest; hence, evaluation tools must be tailored to inform about specific issues. Traditional approaches that summarize grid-based comparisons of analyses and models, or between current and future climate, often do not reveal important information about the models' performance (e.g., spatial or temporal displacements; the reason behind a poor score) and are unable to accommodate these specific information needs. For example, summary statistics such as the correlation coefficient or the mean-squared error provide minimal information to developers, users, and decision makers regarding what is "right" and "wrong" with a model. New spatial and temporal-spatial object-based tools from the field of weather forecast verification (where comparisons typically focus on much finer temporal and spatial scales) have been adapted to more completely answer some of the important earth system model evaluation questions. In particular, the Method for Object-based Diagnostic Evaluation (MODE) tool and its temporal (three-dimensional) extension (MODE-TD) have been adapted for these evaluations. More specifically, these tools can be used to address spatial and temporal displacements in projections of El Nino-related precipitation and/or temperature anomalies, ITCZ-associated precipitation areas, atmospheric rivers, seasonal sea-ice extent, and other features of interest. Examples of several applications of these tools in a climate context will be presented, using output of the CESM large ensemble. In general, these tools provide diagnostic information about model performance - accounting for spatial, temporal, and intensity differences - that cannot be achieved using traditional (scalar) model comparison approaches. Thus, they can provide more meaningful information that can be used in decision-making and planning. Future extensions and applications of these tools in a climate context will be considered.

Generalized Criteria and Evaluation Method for Center of Excellence: A Preliminary Report

DTIC Science & Technology

2009-12-01

center of excellence for the domain MIMOSA . 1 As part of the establishment, AMRDEC SED recommended that each such organization be required to be...Information Management Open Systems Alliance ( MIMOSA ) is a not-for-profit trade association dedicated to developing and encouraging the adoption of open...focused on a specific domain— MIMOSA , for example. Rather, these characteristics are described in terms of assigned mission area, thereby being

Process gas hear recovery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, W.M.; Thurner, R.P.

1977-01-01

In considering the use of regenerative and recuperative heat exchangers for process-gas heat recovery general information regarding heat-exchanger effectiveness versus initial capital investment and operating costs is discussed. Specific examples for preheating combustion air for process furnaces and for using primary and secondary heat exchangers in conjunction with an air-pollution-control system for drying and curing ovens cover basic heat-exchanger design and application considerations as well as investment-payback factors.

Large space structures control algorithm characterization

NASA Technical Reports Server (NTRS)

Fogel, E.

1983-01-01

Feedback control algorithms are developed for sensor/actuator pairs on large space systems. These algorithms have been sized in terms of (1) floating point operation (FLOP) demands; (2) storage for variables; and (3) input/output data flow. FLOP sizing (per control cycle) was done as a function of the number of control states and the number of sensor/actuator pairs. Storage for variables and I/O sizing was done for specific structure examples.

Specification Improvement Through Analysis of Proof Structure (SITAPS): High Assurance Software Development

DTIC Science & Technology

2016-02-01

proof in mathematics. For example, consider the proof of the Pythagorean Theorem illustrated at: http://www.cut-the-knot.org/ pythagoras / where 112...methods and tools have made significant progress in their ability to model software designs and prove correctness theorems about the systems modeled...assumption criticality” or “ theorem root set size” SITAPS detects potentially brittle verification cases. SITAPS provides tools and techniques that

Sierra Structural Dynamics User's Notes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reese, Garth M.

2015-10-19

Sierra/SD provides a massively parallel implementation of structural dynamics finite element analysis, required for high fidelity, validated models used in modal, vibration, static and shock analysis of weapons systems. This document provides a users guide to the input for Sierra/SD. Details of input specifications for the different solution types, output options, element types and parameters are included. The appendices contain detailed examples, and instructions for running the software on parallel platforms.

Finding a Way into a Family of Tone Languages: The Story and Methods of the Chatino Language Documentation Project

ERIC Educational Resources Information Center

Cruz, Emily; Woodbury, Anthony C.

2014-01-01

We give a narrative description of our ten-year path into the elaborate tonal systems of the Chatino languages (Otomanguean; Oaxaca, Mexico), and of some of the methods we have used and recommend, illustrated with specific examples. The work, ongoing at the time of writing, began when one of us (Cruz), a native speaker of San Juan Quiahije…

Computer Graphics Animation for Objective Self-Evaluation.

PubMed

Usui, Yoko; Sato, Katsumi; Watabe, Shinichi

2017-01-01

The increased number of students enrolling in dance classes in Japan has resulted in a shortage of qualified instructors, leaving classes to be taught by instructors who are not trained in dance. The authors developed a system specifically designed to help nonqualified dance instructors teach dance using motion capture and animation. The goal is to allow dancers to easily self-evaluate their own performances by comparing it to a standard example.

Sierra/SD User's Notes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munday, Lynn Brendon; Day, David M.; Bunting, Gregory

Sierra/SD provides a massively parallel implementation of structural dynamics finite element analysis, required for high fidelity, validated models used in modal, vibration, static and shock analysis of weapons systems. This document provides a users guide to the input for Sierra/SD. Details of input specifications for the different solution types, output options, element types and parameters are included. The appendices contain detailed examples, and instructions for running the software on parallel platforms.

A Framework for Designing Optimal Spacecraft Formations

DTIC Science & Technology

2002-09-01

to the Hill- Clohessy - Wiltshire equations were reproduced. For an example using elliptical reference orbits, Reference 17 outlines a solution with...2001. 15. Clohessy , W.H. and Wiltshire , R. S., “Terminal Guidance System for Satellite Rendezvous,” Journal of the Aerospace Sciences, Vol.27, No...Hill- Clohessy -Wiltshire15 (C-W) equations were chosen as the first model specifically because the solutions were known. This allowed a validation

Negative specific heat with trapped ultracold quantum gases

NASA Astrophysics Data System (ADS)

Strzys, M. P.; Anglin, J. R.

2014-01-01

The second law of thermodynamics normally prescribes that heat tends to disperse, but in certain cases it instead implies that heat will spontaneously concentrate. The spontaneous formation of stars out of cold cosmic nebulae, without which the universe would be dark and dead, is an example of this phenomenon. Here we show that the counter-intuitive thermodynamics of spontaneous heat concentration can be studied experimentally with trapped quantum gases, by using optical lattice potentials to realize weakly coupled arrays of simple dynamical subsystems, so that under the standard assumptions of statistical mechanics, the behavior of the whole system can be predicted from ensemble properties of the isolated components. A naive application of the standard statistical mechanical formalism then identifies the subsystem excitations as heat in this case, but predicts them to share the peculiar property of self-gravitating protostars, of having negative micro-canonical specific heat. Numerical solution of real-time evolution equations confirms the spontaneous concentration of heat in such arrays, with initially dispersed energy condensing quickly into dense ‘droplets’. Analysis of the nonlinear dynamics in adiabatic terms allows it to be related to familiar modulational instabilities. The model thus provides an example of a dictionary mesoscopic system, in which the same non-trivial phenomenon can be understood in both thermodynamical and mechanical terms.

Broadband spectroscopy of dynamic impedances with short chirp pulses.

PubMed

Min, M; Land, R; Paavle, T; Parve, T; Annus, P; Trebbels, D

2011-07-01

An impedance spectrum of dynamic systems is time dependent. Fast impedance changes take place, for example, in high throughput microfluidic devices and in operating cardiovascular systems. Measurements must be as short as possible to avoid significant impedance changes during the spectrum analysis, and as long as possible for enlarging the excitation energy and obtaining a better signal-to-noise ratio (SNR). The authors propose to use specific short chirp pulses for excitation. Thanks to the specific properties of the chirp function, it is possible to meet the needs for a spectrum bandwidth, measurement time and SNR so that the most accurate impedance spectrogram can be obtained. The chirp wave excitation can include thousands of cycles when the impedance changes slowly, but in the case of very high speed changes it can be shorter than a single cycle, preserving the same excitation bandwidth. For example, a 100 kHz bandwidth can be covered by the chirp pulse with durations from 10 µs to 1 s; only its excitation energy differs also 10(5) times. After discussing theoretical short chirp properties in detail, the authors show how to generate short chirps in the microsecond range with a bandwidth up to a few MHz by using digital synthesis architectures developed inside a low-cost standard field programmable gate array.

Child-Specific Exposure Scenarios Examples (Final Report) ...

EPA Pesticide Factsheets

EPA announced the availability of the final report, Child-Specific Exposure Scenarios Examples. This report is intended to be a companion document to the Exposure Factors Handbook (U.S. EPA 2011). The example scenarios were compiled from questions and inquiries received from users of the Exposure Factors Handbook (EFH) on how to select data from the EFH to assess childhood exposures. The scenarios presented in this report promote the use of the standard set of age groups recommended by the U.S. EPA in the report entitled Guidance on Selecting Age Groups for Monitoring and Assessing Childhood Exposures to Environmental Contaminants (U.S. EPA 2005). The purpose of the Child-Specific Exposure Scenarios Examples Report is to outline scenarios for various child-specific exposure pathways and to demonstrate how data from the Exposure Factors Handbook (U.S. EPA, 2011) may be applied for estimating exposures. The handbook provides data on drinking water consumption, soil ingestion, mouthing behavior, inhalation rates, dermal factors including skin area and soil adherence factors, consumption of fruits and vegetables, fish, meats, dairy products, homegrown foods, human milk, activity patterns, body weight, and consumer products. The example scenarios presented here have been selected to best demonstrate the use of the various key data sets in the Child-Specific Exposure Factors Handbook (U.S. EPA, 2008a), and represent commonly encountered exposure pathways. An exhausti

Reference Gauging System for a Small-Scale Liquid Hydrogen Tank

NASA Technical Reports Server (NTRS)

VanDresar, Neil T.; Siegwarth, James D.

2003-01-01

A system to accurately weigh the fluid contents of a small-scale liquid hydrogen test tank has been experimentally verified. It is intended for use as a reference or benchmark system when testing lowgravity liquid quantity gauging concepts in the terrestrial environment. The reference gauging system has shown a repeatable measurement accuracy of better than 0.5 percent of the full tank liquid weight. With further refinement, the system accuracy can be improved to within 0.10 percent of full scale. This report describes the weighing system design, calibration, and operational results. Suggestions are given for further refinement of the system. An example is given to illustrate additional sources of uncertainty when mass measurements are converted to volume equivalents. Specifications of the companion test tank and its multi-layer insulation system are provided.

Behavioural conditioning of immune functions: how the central nervous system controls peripheral immune responses by evoking associative learning processes.

PubMed

Riether, Carsten; Doenlen, Raphaël; Pacheco-López, Gustavo; Niemi, Maj-Britt; Engler, Andrea; Engler, Harald; Schedlowski, Manfred

2008-01-01

During the last 30 years of psychoneuroimmunology research the intense bi-directional communication between the central nervous system (CNS) and the immune system has been demonstrated in studies on the interaction between the nervous-endocrine-immune systems. One of the most intriguing examples of such interaction is the capability of the CNS to associate an immune status with specific environmental stimuli. In this review, we systematically summarize experimental evidence demonstrating the behavioural conditioning of peripheral immune functions. In particular, we focus on the mechanisms underlying the behavioural conditioning process and provide a theoretical framework that indicates the potential feasibility of behaviourally conditioned immune changes in clinical situations.

Theory and design of interferometric synthetic aperture radars

NASA Technical Reports Server (NTRS)

Rodriguez, E.; Martin, J. M.

1992-01-01

A derivation of the signal statistics, an optimal estimator of the interferometric phase, and the expression necessary to calculate the height-error budget are presented. These expressions are used to derive methods of optimizing the parameters of the interferometric synthetic aperture radar system (InSAR), and are then employed in a specific design example for a system to perform high-resolution global topographic mapping with a one-year mission lifetime, subject to current technological constraints. A Monte Carlo simulation of this InSAR system is performed to evaluate its performance for realistic topography. The results indicate that this system has the potential to satisfy the stringent accuracy and resolution requirements for geophysical use of global topographic data.

Standardized verification of fuel cycle modeling

DOE PAGES

Feng, B.; Dixon, B.; Sunny, E.; ...

2016-04-05

A nuclear fuel cycle systems modeling and code-to-code comparison effort was coordinated across multiple national laboratories to verify the tools needed to perform fuel cycle analyses of the transition from a once-through nuclear fuel cycle to a sustainable potential future fuel cycle. For this verification study, a simplified example transition scenario was developed to serve as a test case for the four systems codes involved (DYMOND, VISION, ORION, and MARKAL), each used by a different laboratory participant. In addition, all participants produced spreadsheet solutions for the test case to check all the mass flows and reactor/facility profiles on a year-by-yearmore » basis throughout the simulation period. The test case specifications describe a transition from the current US fleet of light water reactors to a future fleet of sodium-cooled fast reactors that continuously recycle transuranic elements as fuel. After several initial coordinated modeling and calculation attempts, it was revealed that most of the differences in code results were not due to different code algorithms or calculation approaches, but due to different interpretations of the input specifications among the analysts. Therefore, the specifications for the test case itself were iteratively updated to remove ambiguity and to help calibrate interpretations. In addition, a few corrections and modifications were made to the codes as well, which led to excellent agreement between all codes and spreadsheets for this test case. Although no fuel cycle transition analysis codes matched the spreadsheet results exactly, all remaining differences in the results were due to fundamental differences in code structure and/or were thoroughly explained. As a result, the specifications and example results are provided so that they can be used to verify additional codes in the future for such fuel cycle transition scenarios.« less

Development and localisation of casemix applications for inpatient hospital activity in EU member states.

PubMed

Wiley, M M

1999-01-01

The successful infiltration of casemix techniques across geographical, systemic and cultural boundaries provides an interesting and timely example of the translation of research evidence into health policy development. This paper explores the specifics of this policy development by reviewing the application of casemix techniques within the acute hospital systems of European Union member states. The fact that experimentation with or application of casemix measures can be reported for the majority of European Union member states would suggest that the deployment of these measures can be expected to continue to expand within these health systems into the new millennium.

Advanced Methods for Incorporating Solar Energy Technologies into Electric Sector Capacity-Expansion Models: Literature Review and Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sullivan, P.; Eurek, K.; Margolis, R.

2014-07-01

Because solar power is a rapidly growing component of the electricity system, robust representations of solar technologies should be included in capacity-expansion models. This is a challenge because modeling the electricity system--and, in particular, modeling solar integration within that system--is a complex endeavor. This report highlights the major challenges of incorporating solar technologies into capacity-expansion models and shows examples of how specific models address those challenges. These challenges include modeling non-dispatchable technologies, determining which solar technologies to model, choosing a spatial resolution, incorporating a solar resource assessment, and accounting for solar generation variability and uncertainty.

34 CFR 656.23 - What priorities may the Secretary establish?

Code of Federal Regulations, 2010 CFR

2010-07-01

... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA... priorities: (1) Specific countries or world areas, such as, for example, East Asia, Africa, or the Middle East. (2) Specific focus of a Center, such as, for example, a single world area; international studies...

Archive of Digital Boomer and CHIRP Seismic Reflection Data Collected During USGS Field Activity 08LCA03 in Lake Panasoffkee, Florida, May 2008

USGS Publications Warehouse

Harrison, Arnell S.; Dadisman, Shawn V.; McBride, W. Scott; Flocks, James G.; Wiese, Dana S.

2009-01-01

In May of 2008, the U.S. Geological Survey (USGS) conducted geophysical surveys in Lake Panasoffkee, located in central Florida, as part of the USGS Lakes and Coastal Aquifers (LCA) study. This report serves as an archive of unprocessed digital boomer and Compressed High Intensity Radar Pulse (CHIRP)* seismic reflection data, trackline maps, navigation files, Field Activity Collection System (FACS) logs, Geographic Information System (GIS) files, and formal Federal Geographic Data Committee (FGDC) metadata. Filtered and gained (a relative increase in signal amplitude) digital images of the seismic profiles and geospatially corrected interactive profiles are also provided. Refer to the Acronyms page for expansions of acronyms and abbreviations used in this report. *Due to poor data acquisition conditions associated with the lake bottom sediments, only two CHIRP tracklines were collected during this field activity. The archived trace data are in standard Society of Exploration Geophysicists (SEG) SEG-Y format (Barry and others, 1975) and may be downloaded and processed with commercial or public domain software such as Seismic Unix (SU). Example SU processing scripts and USGS software for viewing the SEG-Y files (Zihlman, 1992) are provided. The USGS Florida Integrated Science Center (FISC) - St. Petersburg assigns a unique identifier to each cruise or field activity. For example, 08LCA03 tells us the data were collected in 2008 for the Lakes and Coastal Aquifers (LCA) study and the data were collected during the third field activity for that study in that calendar year. Refer to http://walrus.wr.usgs.gov/infobank/programs/html/definition/activity.html for a detailed description of the method used to assign the field activity ID. The naming convention used for each seismic line is as follows: yye##a, where 'yy' are the last two digits of the year in which the data were collected, 'e' is a 1-letter abbreviation for the equipment type (for example, b for boomer and c for CHIRP), '##' is a 2-digit number representing a specific track, and 'a' is a letter representing the section of a line if recording was prematurely terminated or rerun for quality or acquisition problems. The boomer plate is an acoustic energy source that consists of capacitors charged to a high voltage and discharged through a transducer in the water. The transducer is towed on a sled floating on the water surface and, when discharged, emits a short acoustic pulse, or shot, which propagates through the water, sediment column, or rock beneath. The acoustic energy is reflected at density boundaries (such as the seafloor, sediment, or rock layers beneath the seafloor), detected by the receiver, and recorded by a PC-based seismic acquisition system. This process is repeated at timed intervals (for example, 0.5 s) and recorded for specific intervals of time (for example, 100 ms). In this way, a two-dimensional (2-D) vertical profile of the shallow geologic structure beneath the ship track is produced. Figure 1 displays the boomer acquisition geometry. The EdgeTech SB-424 CHIRP system used for this survey has a vertical resolution of 4 - 8 cm, a penetration depth that is usually less than 2 m beneath the seafloor, and uses a signal of continuously varying frequency. The towfish is a sound source and receiver, which is typically towed 2 - 5 m above the seafloor. The acoustic energy is reflected at density boundaries (such as the seafloor or sediment layers beneath the seafloor), detected by a receiver, and recorded by a PC-based seismic acquisition system. This process is repeated at timed intervals (for example, 0.125 s) and recorded for specific intervals of time (for example, 50 ms); the resulting profile is a two-dimensional vertical image of the shallow geologic structure beneath the ship track. Figure 2 displays the acquisition geometry for the CHIRP system. Refer to table 1 for a summary of acquisition parameters and table 2 for trackline statistics.

Regulation of Conduction Time along Axons

PubMed Central

Seidl, Armin H.

2013-01-01

Timely delivery of information is essential for proper function of the nervous system. Precise regulation of nerve conduction velocity is needed for correct exertion of motor skills, sensory integration and cognitive functions. In vertebrates, the rapid transmission of signals along nerve fibers is made possible by the myelination of axons and the resulting saltatory conduction in between nodes of Ranvier. Myelin is a specialization of glia cells and is provided by oligodendrocytes in the central nervous system. Myelination not only maximizes conduction velocity, but also provides a means to systematically regulate conduction times in the nervous system. Systematic regulation of conduction velocity along axons, and thus systematic regulation of conduction time in between neural areas, is a common occurrence in the nervous system. To date, little is understood about the mechanism that underlies systematic conduction velocity regulation and conduction time synchrony. Node assembly, internode distance (node spacing) and axon diameter - all parameters determining the speed of signal propagation along axons - are controlled by myelinating glia. Therefore, an interaction between glial cells and neurons has been suggested. This review summarizes examples of neural systems in which conduction velocity is regulated by anatomical variations along axons. While functional implications in these systems are not always clear, recent studies in the auditory system of birds and mammals present examples of conduction velocity regulation in systems with high temporal precision and a defined biological function. Together these findings suggest an active process that shapes the interaction between axons and myelinating glia to control conduction velocity along axons. Future studies involving these systems may provide further insight into how specific conduction times in the brain are established and maintained in development. Throughout the text, conduction velocity is used for the speed of signal propagation, i.e. the speed at which an action potential travels. Conduction time refers to the time it takes for a specific signal to travel from its origin to its target, i.e. neuronal cell body to axonal terminal. PMID:23820043

An overview of clinical and commercial impact of drug delivery systems.

PubMed

Anselmo, Aaron C; Mitragotri, Samir

2014-09-28

Drug delivery systems are widely researched and developed to improve the delivery of pharmaceutical compounds and molecules. The last few decades have seen a marked growth of the field fueled by increased number of researchers, research funding, venture capital and the number of start-ups. Collectively, the growth has led to novel systems that make use of micro/nano-particles, transdermal patches, inhalers, drug reservoir implants and antibody-drug conjugates. While the increased research activity is clearly an indication of proliferation of the field, clinical and commercial translation of early-stage research ideas is critically important for future growth and interest in the field. Here, we will highlight some of the examples of novel drug delivery systems that have undergone such translation. Specifically, we will discuss the developments, advantages, limitations and lessons learned from: (i) microparticle-based depot formulations, (ii) nanoparticle-based cancer drugs, (iii) transdermal systems, (iv) oral drug delivery systems, (v) pulmonary drug delivery, (vi) implants and (vii) antibody-drug conjugates. These systems have impacted treatment of many prevalent diseases including diabetes, cancer and cardiovascular diseases, among others. At the same time, these systems are integral and enabling components of products that collectively generate annual revenues exceeding US $100 billion. These examples provide strong evidence of the clinical and commercial impact of drug delivery systems. Copyright © 2013 Elsevier B.V. All rights reserved.

Correlation between number of type 2 serotonin receptors in the frontal cortex and intensity of serotonin-induced head jerks in mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popova, N.K.; Kulikov, A.V.; Pak, D.F.

This paper shows interlinear differences discovered in the number of S2 receptors in the cerebral cortex and they are compared with the intensity of 5-HT-induced head jerking in mice of inbred lines. The number of S2 receptors was estimated from the quantity of tritium-spiperone, which is specifically bound by brain membrane preparations. Specific binding was assessed as the difference between the quantity of label bound in the absence and in the presence of methylsergide, a drug which specificably blocks S2 receptors. The presence of high correlation be= tween the number of S2 receptors and the number of head jerkings inmore » mice reflects a genetic connection between this form of behavior and the serotonin system, and it in no way signifies that this phenomenon is controlled purely by the serotonin system and cannot be modulated by other mediator systems, for example, the adrenergic system.« less

Human computer interface guide, revision A

NASA Technical Reports Server (NTRS)

1993-01-01

The Human Computer Interface Guide, SSP 30540, is a reference document for the information systems within the Space Station Freedom Program (SSFP). The Human Computer Interface Guide (HCIG) provides guidelines for the design of computer software that affects human performance, specifically, the human-computer interface. This document contains an introduction and subparagraphs on SSFP computer systems, users, and tasks; guidelines for interactions between users and the SSFP computer systems; human factors evaluation and testing of the user interface system; and example specifications. The contents of this document are intended to be consistent with the tasks and products to be prepared by NASA Work Package Centers and SSFP participants as defined in SSP 30000, Space Station Program Definition and Requirements Document. The Human Computer Interface Guide shall be implemented on all new SSFP contractual and internal activities and shall be included in any existing contracts through contract changes. This document is under the control of the Space Station Control Board, and any changes or revisions will be approved by the deputy director.

A Hybrid FPGA-Based System for EEG- and EMG-Based Online Movement Prediction.

PubMed

Wöhrle, Hendrik; Tabie, Marc; Kim, Su Kyoung; Kirchner, Frank; Kirchner, Elsa Andrea

2017-07-03

A current trend in the development of assistive devices for rehabilitation, for example exoskeletons or active orthoses, is to utilize physiological data to enhance their functionality and usability, for example by predicting the patient's upcoming movements using electroencephalography (EEG) or electromyography (EMG). However, these modalities have different temporal properties and classification accuracies, which results in specific advantages and disadvantages. To use physiological data analysis in rehabilitation devices, the processing should be performed in real-time, guarantee close to natural movement onset support, provide high mobility, and should be performed by miniaturized systems that can be embedded into the rehabilitation device. We present a novel Field Programmable Gate Array (FPGA) -based system for real-time movement prediction using physiological data. Its parallel processing capabilities allows the combination of movement predictions based on EEG and EMG and additionally a P300 detection, which is likely evoked by instructions of the therapist. The system is evaluated in an offline and an online study with twelve healthy subjects in total. We show that it provides a high computational performance and significantly lower power consumption in comparison to a standard PC. Furthermore, despite the usage of fixed-point computations, the proposed system achieves a classification accuracy similar to systems with double precision floating-point precision.

A Hybrid FPGA-Based System for EEG- and EMG-Based Online Movement Prediction

PubMed Central

Wöhrle, Hendrik; Tabie, Marc; Kim, Su Kyoung; Kirchner, Frank; Kirchner, Elsa Andrea

2017-01-01

A current trend in the development of assistive devices for rehabilitation, for example exoskeletons or active orthoses, is to utilize physiological data to enhance their functionality and usability, for example by predicting the patient’s upcoming movements using electroencephalography (EEG) or electromyography (EMG). However, these modalities have different temporal properties and classification accuracies, which results in specific advantages and disadvantages. To use physiological data analysis in rehabilitation devices, the processing should be performed in real-time, guarantee close to natural movement onset support, provide high mobility, and should be performed by miniaturized systems that can be embedded into the rehabilitation device. We present a novel Field Programmable Gate Array (FPGA) -based system for real-time movement prediction using physiological data. Its parallel processing capabilities allows the combination of movement predictions based on EEG and EMG and additionally a P300 detection, which is likely evoked by instructions of the therapist. The system is evaluated in an offline and an online study with twelve healthy subjects in total. We show that it provides a high computational performance and significantly lower power consumption in comparison to a standard PC. Furthermore, despite the usage of fixed-point computations, the proposed system achieves a classification accuracy similar to systems with double precision floating-point precision. PMID:28671632

Systems Biology Markup Language (SBML) Level 2 Version 5: Structures and Facilities for Model Definitions

PubMed Central

Hucka, Michael; Bergmann, Frank T.; Dräger, Andreas; Hoops, Stefan; Keating, Sarah M.; Le Novére, Nicolas; Myers, Chris J.; Olivier, Brett G.; Sahle, Sven; Schaff, James C.; Smith, Lucian P.; Waltemath, Dagmar; Wilkinson, Darren J.

2017-01-01

Summary Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 5 of SBML Level 2. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/. PMID:26528569

Systems Biology Markup Language (SBML) Level 2 Version 5: Structures and Facilities for Model Definitions.

PubMed

Hucka, Michael; Bergmann, Frank T; Dräger, Andreas; Hoops, Stefan; Keating, Sarah M; Le Novère, Nicolas; Myers, Chris J; Olivier, Brett G; Sahle, Sven; Schaff, James C; Smith, Lucian P; Waltemath, Dagmar; Wilkinson, Darren J

2015-09-04

Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 5 of SBML Level 2. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org.

Systems Biology Markup Language (SBML) Level 2 Version 5: Structures and Facilities for Model Definitions.

PubMed

Hucka, Michael; Bergmann, Frank T; Dräger, Andreas; Hoops, Stefan; Keating, Sarah M; Le Novère, Nicolas; Myers, Chris J; Olivier, Brett G; Sahle, Sven; Schaff, James C; Smith, Lucian P; Waltemath, Dagmar; Wilkinson, Darren J

2015-06-01

Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 5 of SBML Level 2. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/.

[Methods in health services research. The example of the evaluation of the German disease management programmes].

PubMed

Morfeld, M; Wirtz, M

2006-02-01

According to the established definition of Pfaff, health services research analyses patients' path through the institutions of the health care system. The focus is on development, evaluation and implementation of innovative measures of health care. By increasing its quality health services research strives for an improvement of efficacy and efficiency of the health care system. In order to allow for an appropriate evaluation it is essential to differentiate between structure, process and outcome quality referring to (1) the health care system in its entirety, (2) specific health care units as well as (3) processes of communication in different settings. Health services research comprises a large array of scientific disciplines like public health, medicine, social sciences and social care. For the purpose of managing its tasks adequately a special combination of instruments and methodological procedures is needed. Thus, diverse techniques of evaluation research as well as special requirements for study designs and assessment procedures are of vital importance. The example of the German disease management programmes illustrates the methodical requirements for a scientific evaluation.

Sustainable intensification: a multifaceted, systemic approach to international development.

PubMed

Himmelstein, Jennifer; Ares, Adrian; van Houweling, Emily

2016-12-01

Sustainable intensification (SI) is a term increasingly used to describe a type of approach applied to international agricultural projects. Despite its widespread use, there is still little understanding or knowledge of the various facets of this composite paradigm. A review of the literature has led to the formalization of three principles that convey the current characterization of SI, comprising a whole system, participatory, agroecological approach. Specific examples of potential bottlenecks to the SI approach are cited, in addition to various technologies and techniques that can be applied to overcome these obstacles. Models of similar, succcessful approaches to agricultural development are examined, along with higher level processes. Additionally, this review explores the desired end points of SI and argues for the inclusion of gender and nutrition throughout the process. To properly apply the SI approach, its various aspects need to be understood and adapted to different cultural and geographic situations. New modeling systems and examples of the effective execution of SI strategies can assist with the successful application of the SI paradigm within complex developing communities. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

Dynamic control and information processing in chemical reaction systems by tuning self-organization behavior

NASA Astrophysics Data System (ADS)

Lebiedz, Dirk; Brandt-Pollmann, Ulrich

2004-09-01

Specific external control of chemical reaction systems and both dynamic control and signal processing as central functions in biochemical reaction systems are important issues of modern nonlinear science. For example nonlinear input-output behavior and its regulation are crucial for the maintainance of the life process that requires extensive communication between cells and their environment. An important question is how the dynamical behavior of biochemical systems is controlled and how they process information transmitted by incoming signals. But also from a general point of view external forcing of complex chemical reaction processes is important in many application areas ranging from chemical engineering to biomedicine. In order to study such control issues numerically, here, we choose a well characterized chemical system, the CO oxidation on Pt(110), which is interesting per se as an externally forced chemical oscillator model. We show numerically that tuning of temporal self-organization by input signals in this simple nonlinear chemical reaction exhibiting oscillatory behavior can in principle be exploited for both specific external control of dynamical system behavior and processing of complex information.

Material requirements for bio-inspired sensing systems

NASA Astrophysics Data System (ADS)

Biggins, Peter; Lloyd, Peter; Salmond, David; Kusterbeck, Anne

2008-10-01

The aim of developing bio-inspired sensing systems is to try and emulate the amazing sensitivity and specificity observed in the natural world. These capabilities have evolved, often for specific tasks, which provide the organism with an advantage in its fight to survive and prosper. Capabilities cover a wide range of sensing functions including vision, temperature, hearing, touch, taste and smell. For some functions, the capabilities of natural systems are still greater than that achieved by traditional engineering solutions; a good example being a dog's sense of smell. Furthermore, attempting to emulate aspects of biological optics, processing and guidance may lead to more simple and effective devices. A bio-inspired sensing system is much more than the sensory mechanism. A system will need to collect samples, especially if pathogens or chemicals are of interest. Other functions could include the provision of power, surfaces and receptors, structure, locomotion and control. In fact it is possible to conceive of a complete bio-inspired system concept which is likely to be radically different from more conventional approaches. This concept will be described and individual component technologies considered.

Power and On-Board Propulsion System Benefit Studies at NASA GRC

NASA Technical Reports Server (NTRS)

Hoffman, David J.

2000-01-01

This paper discusses the value of systems studies that provide unbiased 'honest broker' assessments of the quantified benefits afforded by advanced technologies for specific missions. The organization, format, and approach used by the NASA Glenn Research Center (GRC) Systems Assessment Team (SAT) to perform system studies for the GRC advanced power and on-board propulsion technology development program is described. Three levels of assessments and a sensitivity analysis are explained and example results are presented. The impact of system studies results and some of the main challenges associated with systems studies are identified. A call for collaboration is made where system studies of all types from all organizations can be reviewed, providing a forum for the widest peer review to ensure accurate and unbiased technical content, and to avoid needless duplication.

Gene flow and biological conflict systems in the origin and evolution of eukaryotes

PubMed Central

Aravind, L.; Anantharaman, Vivek; Zhang, Dapeng; de Souza, Robson F.; Iyer, Lakshminarayan M.

2012-01-01

The endosymbiotic origin of eukaryotes brought together two disparate genomes in the cell. Additionally, eukaryotic natural history has included other endosymbiotic events, phagotrophic consumption of organisms, and intimate interactions with viruses and endoparasites. These phenomena facilitated large-scale lateral gene transfer and biological conflicts. We synthesize information from nearly two decades of genomics to illustrate how the interplay between lateral gene transfer and biological conflicts has impacted the emergence of new adaptations in eukaryotes. Using apicomplexans as example, we illustrate how lateral transfer from animals has contributed to unique parasite-host interfaces comprised of adhesion- and O-linked glycosylation-related domains. Adaptations, emerging due to intense selection for diversity in the molecular participants in organismal and genomic conflicts, being dispersed by lateral transfer, were subsequently exapted for eukaryote-specific innovations. We illustrate this using examples relating to eukaryotic chromatin, RNAi and RNA-processing systems, signaling pathways, apoptosis and immunity. We highlight the major contributions from catalytic domains of bacterial toxin systems to the origin of signaling enzymes (e.g., ADP-ribosylation and small molecule messenger synthesis), mutagenic enzymes for immune receptor diversification and RNA-processing. Similarly, we discuss contributions of bacterial antibiotic/siderophore synthesis systems and intra-genomic and intra-cellular selfish elements (e.g., restriction-modification, mobile elements and lysogenic phages) in the emergence of chromatin remodeling/modifying enzymes and RNA-based regulation. We develop the concept that biological conflict systems served as evolutionary “nurseries” for innovations in the protein world, which were delivered to eukaryotes via lateral gene flow to spur key evolutionary innovations all the way from nucleogenesis to lineage-specific adaptations. PMID:22919680

Independent origins of neurons and synapses: insights from ctenophores

PubMed Central

Moroz, Leonid L.; Kohn, Andrea B.

2016-01-01

There is more than one way to develop neuronal complexity, and animals frequently use different molecular toolkits to achieve similar functional outcomes. Genomics and metabolomics data from basal metazoans suggest that neural signalling evolved independently in ctenophores and cnidarians/bilaterians. This polygenesis hypothesis explains the lack of pan-neuronal and pan-synaptic genes across metazoans, including remarkable examples of lineage-specific evolution of neurogenic and signalling molecules as well as synaptic components. Sponges and placozoans are two lineages without neural and muscular systems. The possibility of secondary loss of neurons and synapses in the Porifera/Placozoa clades is a highly unlikely and less parsimonious scenario. We conclude that acetylcholine, serotonin, histamine, dopamine, octopamine and gamma-aminobutyric acid (GABA) were recruited as transmitters in the neural systems in cnidarian and bilaterian lineages. By contrast, ctenophores independently evolved numerous secretory peptides, indicating extensive adaptations within the clade and suggesting that early neural systems might be peptidergic. Comparative analysis of glutamate signalling also shows numerous lineage-specific innovations, implying the extensive use of this ubiquitous metabolite and intercellular messenger over the course of convergent and parallel evolution of mechanisms of intercellular communication. Therefore: (i) we view a neuron as a functional character but not a genetic character, and (ii) any given neural system cannot be considered as a single character because it is composed of different cell lineages with distinct genealogies, origins and evolutionary histories. Thus, when reconstructing the evolution of nervous systems, we ought to start with the identification of particular cell lineages by establishing distant neural homologies or examples of convergent evolution. In a corollary of the hypothesis of the independent origins of neurons, our analyses suggest that both electrical and chemical synapses evolved more than once. PMID:26598724

Personnel controlling system principles and structural goals of the industrial companies

NASA Astrophysics Data System (ADS)

Pimenova, Anna; Kuzmina, Svetlana; Zavialov, Kirill; Ushakova, Elena

2017-10-01

This article peruses the basics of the controlling system, its functions and structural phases of the industrial companies. The personnel controlling of the industrial companies (for examples transportation or energy company) is examined in detail. Controlling system occurs applicable within various activity fields of an enterprise. Modern approaches of the domestic scholars are inspected. Goals and focuses of the personnel controlling system of the industrial companies have been analyzed. Foremost it occurs crucial to analyze and define the entire labor process to figure out primary requirements issued to the labor and employees. In article is offered the road map to follow to structure the purposes of all management system of personnel in the specific organization - in the transportation or energy company or other enterprises.

An electronic regulatory document management system for a clinical trial network.

PubMed

Zhao, Wenle; Durkalski, Valerie; Pauls, Keith; Dillon, Catherine; Kim, Jaemyung; Kolk, Deneil; Silbergleit, Robert; Stevenson, Valerie; Palesch, Yuko

2010-01-01

A computerized regulatory document management system has been developed as a module in a comprehensive Clinical Trial Management System (CTMS) designed for an NIH-funded clinical trial network in order to more efficiently manage and track regulatory compliance. Within the network, several institutions and investigators are involved in multiple trials, and each trial has regulatory document requirements. Some of these documents are trial specific while others apply across multiple trials. The latter causes a possible redundancy in document collection and management. To address these and other related challenges, a central regulatory document management system was designed. This manuscript shares the design of the system as well as examples of it use in current studies. Copyright (c) 2009 Elsevier Inc. All rights reserved.

The formulation of dynamical contact problems with friction in the case of systems of rigid bodies and general discrete mechanical systems—Painlevé and Kane paradoxes revisited

NASA Astrophysics Data System (ADS)

Charles, Alexandre; Ballard, Patrick

2016-08-01

The dynamics of mechanical systems with a finite number of degrees of freedom (discrete mechanical systems) is governed by the Lagrange equation which is a second-order differential equation on a Riemannian manifold (the configuration manifold). The handling of perfect (frictionless) unilateral constraints in this framework (that of Lagrange's analytical dynamics) was undertaken by Schatzman and Moreau at the beginning of the 1980s. A mathematically sound and consistent evolution problem was obtained, paving the road for many subsequent theoretical investigations. In this general evolution problem, the only reaction force which is involved is a generalized reaction force, consistently with the virtual power philosophy of Lagrange. Surprisingly, such a general formulation was never derived in the case of frictional unilateral multibody dynamics. Instead, the paradigm of the Coulomb law applying to reaction forces in the real world is generally invoked. So far, this paradigm has only enabled to obtain a consistent evolution problem in only some very few specific examples and to suggest numerical algorithms to produce computational examples (numerical modeling). In particular, it is not clear what is the evolution problem underlying the computational examples. Moreover, some of the few specific cases in which this paradigm enables to write down a precise evolution problem are known to show paradoxes: the Painlevé paradox (indeterminacy) and the Kane paradox (increase in kinetic energy due to friction). In this paper, we follow Lagrange's philosophy and formulate the frictional unilateral multibody dynamics in terms of the generalized reaction force and not in terms of the real-world reaction force. A general evolution problem that governs the dynamics is obtained for the first time. We prove that all the solutions are dissipative; that is, this new formulation is free of Kane paradox. We also prove that some indeterminacy of the Painlevé paradox is fixed in this formulation.

Study of Design Knowledge Capture (DKC) schemes implemented in magnetic bearing applications

NASA Technical Reports Server (NTRS)

1990-01-01

A design knowledge capture (DKC) scheme was implemented using frame-based techniques. The objective of such a system is to capture not only the knowledge which describes a design, but also that which explains how the design decisions were reached. These knowledge types were labelled definitive and explanatory, respectively. Examination of the design process helped determine what knowledge to retain and at what stage that knowledge is used. A discussion of frames resulted in the recognition of their value to knowledge representation and organization. The FORMS frame system was used as a basis for further development, and for examples using magnetic bearing design. The specific contributions made by this research include: determination that frame-based systems provide a useful methodology for management and application of design knowledge; definition of specific user interface requirements, (this consists of a window-based browser); specification of syntax for DKC commands; and demonstration of the feasibility of DKC by applications to existing designs. It was determined that design knowledge capture could become an extremely valuable engineering tool for complicated, long-life systems, but that further work was needed, particularly the development of a graphic, window-based interface.

Prognostics for Microgrid Components

NASA Technical Reports Server (NTRS)

Saxena, Abhinav

2012-01-01

Prognostics is the science of predicting future performance and potential failures based on targeted condition monitoring. Moving away from the traditional reliability centric view, prognostics aims at detecting and quantifying the time to impending failures. This advance warning provides the opportunity to take actions that can preserve uptime, reduce cost of damage, or extend the life of the component. The talk will focus on the concepts and basics of prognostics from the viewpoint of condition-based systems health management. Differences with other techniques used in systems health management and philosophies of prognostics used in other domains will be shown. Examples relevant to micro grid systems and subsystems will be used to illustrate various types of prediction scenarios and the resources it take to set up a desired prognostic system. Specifically, the implementation results for power storage and power semiconductor components will demonstrate specific solution approaches of prognostics. The role of constituent elements of prognostics, such as model, prediction algorithms, failure threshold, run-to-failure data, requirements and specifications, and post-prognostic reasoning will be explained. A discussion on performance evaluation and performance metrics will conclude the technical discussion followed by general comments on open research problems and challenges in prognostics.

The GOAL-to-HAL/S translator specification. [for space shuttle

NASA Technical Reports Server (NTRS)

Stanten, S. F.; Flanders, J. H.

1973-01-01

The specification sets forth a technical framework within which to deal with the transfer of specific GOAL features to HAL/S. Key technical features of the translator are described which communicate with the data bank, handle repeat statements, and deal with software interrupts. GOAL programs, databank information, and GOAL system subroutines are integrated into one GOAL in HAL/S. This output is fully compatible HAL/S source ready for insertion into the HAL/S compiler. The Translator uses a PASS1 to establish all the global data needed for the HAL/S output program. Individual GOAL statements are translated in PASS2. The specification document makes extensive use of flowcharts to specify exactly how each variation of each GOAL statement is to be translated. The specification also deals with definitions and assumptions, executive support structure and implementation. An appendix, entitled GOAL-to-HAL Mapping, provides examples of translated GOAL statements.

ISHM-oriented adaptive fault diagnostics for avionics based on a distributed intelligent agent system

NASA Astrophysics Data System (ADS)

Xu, Jiuping; Zhong, Zhengqiang; Xu, Lei

2015-10-01

In this paper, an integrated system health management-oriented adaptive fault diagnostics and model for avionics is proposed. With avionics becoming increasingly complicated, precise and comprehensive avionics fault diagnostics has become an extremely complicated task. For the proposed fault diagnostic system, specific approaches, such as the artificial immune system, the intelligent agents system and the Dempster-Shafer evidence theory, are used to conduct deep fault avionics diagnostics. Through this proposed fault diagnostic system, efficient and accurate diagnostics can be achieved. A numerical example is conducted to apply the proposed hybrid diagnostics to a set of radar transmitters on an avionics system and to illustrate that the proposed system and model have the ability to achieve efficient and accurate fault diagnostics. By analyzing the diagnostic system's feasibility and pragmatics, the advantages of this system are demonstrated.

Using SysML for MBSE analysis of the LSST system

NASA Astrophysics Data System (ADS)

Claver, Charles F.; Dubois-Felsmann, Gregory; Delgado, Francisco; Hascall, Pat; Marshall, Stuart; Nordby, Martin; Schalk, Terry; Schumacher, German; Sebag, Jacques

2010-07-01

The Large Synoptic Survey Telescope is a complex hardware - software system of systems, making up a highly automated observatory in the form of an 8.4m wide-field telescope, a 3.2 billion pixel camera, and a peta-scale data processing and archiving system. As a project, the LSST is using model based systems engineering (MBSE) methodology for developing the overall system architecture coded with the Systems Modeling Language (SysML). With SysML we use a recursive process to establish three-fold relationships between requirements, logical & physical structural component definitions, and overall behavior (activities and sequences) at successively deeper levels of abstraction and detail. Using this process we have analyzed and refined the LSST system design, ensuring the consistency and completeness of the full set of requirements and their match to associated system structure and behavior. As the recursion process proceeds to deeper levels we derive more detailed requirements and specifications, and ensure their traceability. We also expose, define, and specify critical system interfaces, physical and information flows, and clarify the logic and control flows governing system behavior. The resulting integrated model database is used to generate documentation and specifications and will evolve to support activities from construction through final integration, test, and commissioning, serving as a living representation of the LSST as designed and built. We discuss the methodology and present several examples of its application to specific systems engineering challenges in the LSST design.

Constructing Scientific Explanations: a System of Analysis for Students' Explanations

NASA Astrophysics Data System (ADS)

de Andrade, Vanessa; Freire, Sofia; Baptista, Mónica

2017-08-01

This article describes a system of analysis aimed at characterizing students' scientific explanations. Science education literature and reform documents have been highlighting the importance of scientific explanations for students' conceptual understanding and for their understanding of the nature of scientific knowledge. Nevertheless, and despite general agreement regarding the potential of having students construct their own explanations, a consensual notion of scientific explanation has still not been reached. As a result, within science education literature, there are several frameworks defining scientific explanations, with different foci as well as different notions of what accounts as a good explanation. Considering this, and based on a more ample project, we developed a system of analysis to characterize students' explanations. It was conceptualized and developed based on theories and models of scientific explanations, science education literature, and from examples of students' explanations collected by an open-ended questionnaire. With this paper, it is our goal to present the system of analysis, illustrating it with specific examples of students' collected explanations. In addition, we expect to point out its adequacy and utility for analyzing and characterizing students' scientific explanations as well as for tracing their progression.

Non-Fermi liquids in oxide heterostructures

NASA Astrophysics Data System (ADS)

Stemmer, Susanne; Allen, S. James

2018-06-01

Understanding the anomalous transport properties of strongly correlated materials is one of the most formidable challenges in condensed matter physics. For example, one encounters metal-insulator transitions, deviations from Landau Fermi liquid behavior, longitudinal and Hall scattering rate separation, a pseudogap phase, and bad metal behavior. These properties have been studied extensively in bulk materials, such as the unconventional superconductors and heavy fermion systems. Oxide heterostructures have recently emerged as new platforms to probe, control, and understand strong correlation phenomena. This article focuses on unconventional transport phenomena in oxide thin film systems. We use specific systems as examples, namely charge carriers in SrTiO3 layers and interfaces with SrTiO3, and strained rare earth nickelate thin films. While doped SrTiO3 layers appear to be a well behaved, though complex, electron gas or Fermi liquid, the rare earth nickelates are a highly correlated electron system that may be classified as a non-Fermi liquid. We discuss insights into the underlying physics that can be gained from studying the emergence of non-Fermi liquid behavior as a function of the heterostructure parameters. We also discuss the role of lattice symmetry and disorder in phenomena such as metal-insulator transitions in strongly correlated heterostructures.

Simplicity and Specificity in Language: Domain-General Biases Have Domain-Specific Effects

PubMed Central

Culbertson, Jennifer; Kirby, Simon

2016-01-01

The extent to which the linguistic system—its architecture, the representations it operates on, the constraints it is subject to—is specific to language has broad implications for cognitive science and its relation to evolutionary biology. Importantly, a given property of the linguistic system can be “specific” to the domain of language in several ways. For example, if the property evolved by natural selection under the pressure of the linguistic function it serves then the property is domain-specific in the sense that its design is tailored for language. Equally though, if that property evolved to serve a different function or if that property is domain-general, it may nevertheless interact with the linguistic system in a way that is unique. This gives a second sense in which a property can be thought of as specific to language. An evolutionary approach to the language faculty might at first blush appear to favor domain-specificity in the first sense, with individual properties of the language faculty being specifically linguistic adaptations. However, we argue that interactions between learning, culture, and biological evolution mean any domain-specific adaptations that evolve will take the form of weak biases rather than hard constraints. Turning to the latter sense of domain-specificity, we highlight a very general bias, simplicity, which operates widely in cognition and yet interacts with linguistic representations in domain-specific ways. PMID:26793132

Genetic and environmental factors interact to influence anxiety.

PubMed

Gross, Cornelius; Hen, René

2004-01-01

Both genetic and environmental factors influence normal anxiety traits as well as anxiety disorders. In addition it is becoming increasingly clear that these factors interact to produce specific anxiety-related behaviors. For example, in humans and in monkeys mutations in the gene encoding for the serotonin transporter result in increased anxiety in adult life when combined with a stressful environment during development. Another recent example comes from twin studies suggesting that a small hippocampus can be a predisposing condition that renders individuals susceptible to post traumatic stress disorder. Such examples illustrate how specific mutations leading to abnormal brain development may increase vulnerability to environmental insults which may in turn lead to specific anxiety disorders.

A Model-Based Approach to Engineering Behavior of Complex Aerospace Systems

NASA Technical Reports Server (NTRS)

Ingham, Michel; Day, John; Donahue, Kenneth; Kadesch, Alex; Kennedy, Andrew; Khan, Mohammed Omair; Post, Ethan; Standley, Shaun

2012-01-01

One of the most challenging yet poorly defined aspects of engineering a complex aerospace system is behavior engineering, including definition, specification, design, implementation, and verification and validation of the system's behaviors. This is especially true for behaviors of highly autonomous and intelligent systems. Behavior engineering is more of an art than a science. As a process it is generally ad-hoc, poorly specified, and inconsistently applied from one project to the next. It uses largely informal representations, and results in system behavior being documented in a wide variety of disparate documents. To address this problem, JPL has undertaken a pilot project to apply its institutional capabilities in Model-Based Systems Engineering to the challenge of specifying complex spacecraft system behavior. This paper describes the results of the work in progress on this project. In particular, we discuss our approach to modeling spacecraft behavior including 1) requirements and design flowdown from system-level to subsystem-level, 2) patterns for behavior decomposition, 3) allocation of behaviors to physical elements in the system, and 4) patterns for capturing V&V activities associated with behavioral requirements. We provide examples of interesting behavior specification patterns, and discuss findings from the pilot project.

Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example

PubMed Central

Gunalan, Kabilar; Chaturvedi, Ashutosh; Howell, Bryan; Duchin, Yuval; Lempka, Scott F.; Patriat, Remi; Sapiro, Guillermo; Harel, Noam; McIntyre, Cameron C.

2017-01-01

Background Deep brain stimulation (DBS) is an established clinical therapy and computational models have played an important role in advancing the technology. Patient-specific DBS models are now common tools in both academic and industrial research, as well as clinical software systems. However, the exact methodology for creating patient-specific DBS models can vary substantially and important technical details are often missing from published reports. Objective Provide a detailed description of the assembly workflow and parameterization of a patient-specific DBS pathway-activation model (PAM) and predict the response of the hyperdirect pathway to clinical stimulation. Methods Integration of multiple software tools (e.g. COMSOL, MATLAB, FSL, NEURON, Python) enables the creation and visualization of a DBS PAM. An example DBS PAM was developed using 7T magnetic resonance imaging data from a single unilaterally implanted patient with Parkinson’s disease (PD). This detailed description implements our best computational practices and most elaborate parameterization steps, as defined from over a decade of technical evolution. Results Pathway recruitment curves and strength-duration relationships highlight the non-linear response of axons to changes in the DBS parameter settings. Conclusion Parameterization of patient-specific DBS models can be highly detailed and constrained, thereby providing confidence in the simulation predictions, but at the expense of time demanding technical implementation steps. DBS PAMs represent new tools for investigating possible correlations between brain pathway activation patterns and clinical symptom modulation. PMID:28441410

XML Based Markup Languages for Specific Domains

NASA Astrophysics Data System (ADS)

Varde, Aparna; Rundensteiner, Elke; Fahrenholz, Sally

A challenging area in web based support systems is the study of human activities in connection with the web, especially with reference to certain domains. This includes capturing human reasoning in information retrieval, facilitating the exchange of domain-specific knowledge through a common platform and developing tools for the analysis of data on the web from a domain expert's angle. Among the techniques and standards related to such work, we have XML, the eXtensible Markup Language. This serves as a medium of communication for storing and publishing textual, numeric and other forms of data seamlessly. XML tag sets are such that they preserve semantics and simplify the understanding of stored information by users. Often domain-specific markup languages are designed using XML, with a user-centric perspective. Standardization bodies and research communities may extend these to include additional semantics of areas within and related to the domain. This chapter outlines the issues to be considered in developing domain-specific markup languages: the motivation for development, the semantic considerations, the syntactic constraints and other relevant aspects, especially taking into account human factors. Illustrating examples are provided from domains such as Medicine, Finance and Materials Science. Particular emphasis in these examples is on the Materials Markup Language MatML and the semantics of one of its areas, namely, the Heat Treating of Materials. The focus of this chapter, however, is not the design of one particular language but rather the generic issues concerning the development of domain-specific markup languages.

Optimal concentrations in transport systems

PubMed Central

Jensen, Kaare H.; Kim, Wonjung; Holbrook, N. Michele; Bush, John W. M.

2013-01-01

Many biological and man-made systems rely on transport systems for the distribution of material, for example matter and energy. Material transfer in these systems is determined by the flow rate and the concentration of material. While the most concentrated solutions offer the greatest potential in terms of material transfer, impedance typically increases with concentration, thus making them the most difficult to transport. We develop a general framework for describing systems for which impedance increases with concentration, and consider material flow in four different natural systems: blood flow in vertebrates, sugar transport in vascular plants and two modes of nectar drinking in birds and insects. The model provides a simple method for determining the optimum concentration copt in these systems. The model further suggests that the impedance at the optimum concentration μopt may be expressed in terms of the impedance of the pure (c = 0) carrier medium μ0 as μopt∼2αμ0, where the power α is prescribed by the specific flow constraints, for example constant pressure for blood flow (α = 1) or constant work rate for certain nectar-drinking insects (α = 6). Comparing the model predictions with experimental data from more than 100 animal and plant species, we find that the simple model rationalizes the observed concentrations and impedances. The model provides a universal framework for studying flows impeded by concentration, and yields insight into optimization in engineered systems, such as traffic flow. PMID:23594815

Concept for an International Standard related to Space Weather Effects on Space Systems

NASA Astrophysics Data System (ADS)

Tobiska, W. Kent; Tomky, Alyssa

There is great interest in developing an international standard related to space weather in order to specify the tools and parameters needed for space systems operations. In particular, a standard is important for satellite operators who may not be familiar with space weather. In addition, there are others who participate in space systems operations that would also benefit from such a document. For example, the developers of software systems that provide LEO satellite orbit determination, radio communication availability for scintillation events (GEO-to-ground L and UHF bands), GPS uncertainties, and the radiation environment from ground-to-space for commercial space tourism. These groups require recent historical data, current epoch specification, and forecast of space weather events into their automated or manual systems. Other examples are national government agencies that rely on space weather data provided by their organizations such as those represented in the International Space Environment Service (ISES) group of 14 national agencies. Designers, manufacturers, and launchers of space systems require real-time, operational space weather parameters that can be measured, monitored, or built into automated systems. Thus, a broad scope for the document will provide a useful international standard product to a variety of engineering and science domains. The structure of the document should contain a well-defined scope, consensus space weather terms and definitions, and internationally accepted descriptions of the main elements of space weather, its sources, and its effects upon space systems. Appendices will be useful for describing expanded material such as guidelines on how to use the standard, how to obtain specific space weather parameters, and short but detailed descriptions such as when best to use some parameters and not others; appendices provide a path for easily updating the standard since the domain of space weather is rapidly changing with new advances in scientific and engineering understanding. We present a draft outline that can be used as the basis for such a standard.

Big data to smart data in Alzheimer's disease: Real-world examples of advanced modeling and simulation.

PubMed

Haas, Magali; Stephenson, Diane; Romero, Klaus; Gordon, Mark Forrest; Zach, Neta; Geerts, Hugo

2016-09-01

Many disease-modifying clinical development programs in Alzheimer's disease (AD) have failed to date, and development of new and advanced preclinical models that generate actionable knowledge is desperately needed. This review reports on computer-based modeling and simulation approach as a powerful tool in AD research. Statistical data-analysis techniques can identify associations between certain data and phenotypes, such as diagnosis or disease progression. Other approaches integrate domain expertise in a formalized mathematical way to understand how specific components of pathology integrate into complex brain networks. Private-public partnerships focused on data sharing, causal inference and pathway-based analysis, crowdsourcing, and mechanism-based quantitative systems modeling represent successful real-world modeling examples with substantial impact on CNS diseases. Similar to other disease indications, successful real-world examples of advanced simulation can generate actionable support of drug discovery and development in AD, illustrating the value that can be generated for different stakeholders. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Application of predictive modelling techniques in industry: from food design up to risk assessment.

PubMed

Membré, Jeanne-Marie; Lambert, Ronald J W

2008-11-30

In this communication, examples of applications of predictive microbiology in industrial contexts (i.e. Nestlé and Unilever) are presented which cover a range of applications in food safety from formulation and process design to consumer safety risk assessment. A tailor-made, private expert system, developed to support safe product/process design assessment is introduced as an example of how predictive models can be deployed for use by non-experts. Its use in conjunction with other tools and software available in the public domain is discussed. Specific applications of predictive microbiology techniques are presented relating to investigations of either growth or limits to growth with respect to product formulation or process conditions. An example of a probabilistic exposure assessment model for chilled food application is provided and its potential added value as a food safety management tool in an industrial context is weighed against its disadvantages. The role of predictive microbiology in the suite of tools available to food industry and some of its advantages and constraints are discussed.

[Sibling relations between individuation and attachment: attempt at a conceptualization].

PubMed

Seiffge-Krenke, I

2001-01-01

Although sibling relationships can be considered as one of the most durable and intensive relationships, not much research in developmental psychology and family research has been done on this issue. The strong focus on parents, more specifically on mothers, stood in the way of adequate conceptualization and understanding of the function and contribution of siblings to individual development and family interaction. In this contribution a conceptualization of sibling relationships is presented. Siblings as objects of aggressive and sexual feelings as well as the function of siblings in the family system, for example, as parentification and negative identity is emphasized. In addition, the different qualities of sibling relationships, for example, envy, rivalry, similarity, and difference, are emphasized. The function of siblings as love objects is stressed, and the role of siblings as support as well as teaching object is illustrated. Finally, it is emphasized that, similar to relationships between parents and child, the quality of sibling relationships changed over time and leads, for example, to a detachment between sibling relationships during adolescence.

Topological analysis of metabolic networks based on petri net theory.

PubMed

Zevedei-Oancea, Ionela; Schuster, Stefan

2011-01-01

Petri net concepts provide additional tools for the modelling of metabolic networks. Here, the similarities between the counterparts in traditional biochemical modelling and Petri net theory are discussed. For example the stoichiometry matrix of a metabolic network corresponds to the incidence matrix of the Petri net. The flux modes and conservation relations have the T-invariants, respectively, P-invariants as counterparts. We reveal the biological meaning of some notions specific to the Petri net framework (traps, siphons, deadlocks, liveness). We focus on the topological analysis rather than on the analysis of the dynamic behaviour. The treatment of external metabolites is discussed. Some simple theoretical examples are presented for illustration. Also the Petri nets corresponding to some biochemical networks are built to support our results. For example, the role of triose phosphate isomerase (TPI) in Trypanosoma brucei metabolism is evaluated by detecting siphons and traps. All Petri net properties treated in this contribution are exemplified on a system extracted from nucleotide metabolism.

Topological analysis of metabolic networks based on Petri net theory.

PubMed

Zevedei-Oancea, Ionela; Schuster, Stefan

2003-01-01

Petri net concepts provide additional tools for the modelling of metabolic networks. Here, the similarities between the counterparts in traditional biochemical modelling and Petri net theory are discussed. For example the stoichiometry matrix of a metabolic network corresponds to the incidence matrix of the Petri net. The flux modes and conservation relations have the T-invariants, respectively, P-invariants as counterparts. We reveal the biological meaning of some notions specific to the Petri net framework (traps, siphons, deadlocks, liveness). We focus on the topological analysis rather than on the analysis of the dynamic behaviour. The treatment of external metabolites is discussed. Some simple theoretical examples are presented for illustration. Also the Petri nets corresponding to some biochemical networks are built to support our results. For example, the role of triose phosphate isomerase (TPI) in Trypanosoma brucei metabolism is evaluated by detecting siphons and traps. All Petri net properties treated in this contribution are exemplified on a system extracted from nucleotide metabolism.

The Role of Problem Specification Workshops in Extension: An IPM Example.

ERIC Educational Resources Information Center

Foster, John; And Others

1995-01-01

Of three extension models--top-down technology transfer, farmers-first approach, and participatory research--the latter extends elements of the other two into a more comprehensive analysis of a problem and specification of solution strategies. An Australian integrated pest management (IPM) example illustrates how structured workshops are a useful…

PC Software graphics tool for conceptual design of space/planetary electrical power systems

NASA Technical Reports Server (NTRS)

Truong, Long V.

1995-01-01

This paper describes the Decision Support System (DSS), a personal computer software graphics tool for designing conceptual space and/or planetary electrical power systems. By using the DSS, users can obtain desirable system design and operating parameters, such as system weight, electrical distribution efficiency, and bus power. With this tool, a large-scale specific power system was designed in a matter of days. It is an excellent tool to help designers make tradeoffs between system components, hardware architectures, and operation parameters in the early stages of the design cycle. The DSS is a user-friendly, menu-driven tool with online help and a custom graphical user interface. An example design and results are illustrated for a typical space power system with multiple types of power sources, frequencies, energy storage systems, and loads.

Protein Stabilization and Enzyme Activation in Ionic Liquids: Specific Ion Effects

PubMed Central

Zhao, Hua

2015-01-01

There are still debates on whether the hydration of ions perturbs the water structure, and what is the degree of such disturbance; therefore, the origin of Hofmeister effect on protein stabilization continues being questioned. For this reason, it is suggested to use the ‘specific ion effect’ instead of other misleading terms such as Hofmeister effect, Hofmeister series, lyotropic effect, and lyotropic series. In this review, we firstly discuss the controversial aspect of inorganic ion effects on water structures, and several possible contributors to the specific ion effect of protein stability. Due to recent overwhelming attraction of ionic liquids (ILs) as benign solvents in many enzymatic reactions, we further evaluate the structural properties and molecular-level interactions in neat ILs and their aqueous solutions. Next, we systematically compare the specific ion effects of ILs on enzyme stability and activity, and conclude that (a) the specificity of many enzymatic systems in diluted aqueous IL solutions is roughly in line with the traditional Hofmeister series albeit some exceptions; (b) however, the specificity follows a different track in concentrated or neat ILs because other factors (such as hydrogen-bond basicity, nucelophilicity, and hydrophobicity, etc) are playing leading roles. In addition, we demonstrate some examples of biocatalytic reactions in IL systems that are guided by the empirical specificity rule. PMID:26949281

Medical Device Guidebook: A browser information resource for medical device users.

PubMed

Clarkson, Douglas M

2017-03-01

A web based information resource - the 'Medical Device Guidebook' - for the enabling of safe use of medical devices is described. Medical devices are described within a 'catalogue' of specific models and information on a specific model is provided within a consistent set of information 'keys'. These include 'user manuals', 'points of caution', 'clinical use framework', 'training/assessment material', 'frequently asked questions', 'authorised user comments' and 'consumables'. The system allows identification of known risk/hazards associated with specific devices, triggered, for example, by national alerts or locally raised safety observations. This provides a mechanism for more effective briefing of equipment users on the associated hazards of equipment. A feature of the system is the inclusion of a specific 'Operational Procedure' for each device, where the lack of this focus is shown in the literature to often be a key factor in equipment misuse and associated patient injury. The 'Guidebook' provides a mechanism for the development of an information resource developed within local clinical networks and encourages a consistent approach to medical device use. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

Neotectonics of the San Andreas Fault system: Basin and range province juncture

NASA Technical Reports Server (NTRS)

Estes, J. E.; Crowell, J. C. (Principal Investigator)

1981-01-01

A thorough evaluation of all LANDSAT coverage of the study area (considering atmospheric clarity, seasonal aspects, specific swath location, and digital quality) resulted in the selection of two consecutive (continuously recorded) scenes for detailed analyses. The acquisition of HCMM and SEASAT imagery as well as high altitude U-2 uniform coverage is being considered. A bibliography of previous geological studies and methodological examples is estimated to be 70% complete.

Visual accommodation trainer-tester

NASA Technical Reports Server (NTRS)

Randle, R. J., Jr. (Inventor)

1983-01-01

An apparatus for training of the human visual accommodation system is presented, specifically, useful for training a person to volitionally control his focus to his far point (normaly infinity) from a position of myopia due to functional causes. The functional causes could be due, for example, to a behavioral accommodative spasm or the effects of an empty field. The device may also be used to measure accommodation, the accommodation resting position and the near and far points of vision.

Qualification of an evaluated butterfly-packaged DFB laser designed for space applications

NASA Astrophysics Data System (ADS)

Tornow, S.; Stier, C.; Buettner, T.; Laurent, T.; Kneier, M.; Bru, J.; Lien, Y.

2017-11-01

An extended qualification program has proven the quality of a previously evaluated semiconductor laser diode, which is intended to be used in a subsystem for the GAIA mission. We report on results of several reliability tests performed in subgroups. The requirements of the procurement specification with respect to reliability and desired manufacturing processes were confirmed. This is an example for successful collaboration between component supplier, system integrator and payload responsible party.

Sonar Transducer Reliability Improvement Program (STRIP) FY81.

DTIC Science & Technology

1981-10-01

that must be considered when selecting a material for the design of a sonar transducer. In the past decade, plastics have decreased in cost and...required in a sonar transducer system. A recent example of this type of failure has been with a neoprene .tfer formulation which was designed to meet...subject of the first design specification for transducer elastomers. Previous work on this material under the aegis of the Sonar Transduction

Graphic design of pinhole cameras

NASA Technical Reports Server (NTRS)

Edwards, H. B.; Chu, W. P.

1979-01-01

The paper describes a graphic technique for the analysis and optimization of pinhole size and focal length. The technique is based on the use of the transfer function of optical elements described by Scott (1959) to construct the transfer function of a circular pinhole camera. This transfer function is the response of a component or system to a pattern of lines having a sinusoidally varying radiance at varying spatial frequencies. Some specific examples of graphic design are presented.

Stockpile Dismantlement Database Training Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-11-01

This document, the Stockpile Dismantlement Database (SDDB) training materials is designed to familiarize the user with the SDDB windowing system and the data entry steps for Component Characterization for Disposition. The foundation of information required for every part is depicted by using numbered graphic and text steps. The individual entering data is lead step by step through generic and specific examples. These training materials are intended to be supplements to individual on-the-job training.

Putting the enterprise into the enterprise system.

PubMed

Davenport, T H

1998-01-01

Enterprise systems present a new model of corporate computing. They allow companies to replace their existing information systems, which are often incompatible with one another, with a single, integrated system. By streamlining data flows throughout an organization, these commercial software packages, offered by vendors like SAP, promise dramatic gains in a company's efficiency and bottom line. It's no wonder that businesses are rushing to jump on the ES bandwagon. But while these systems offer tremendous rewards, the risks they carry are equally great. Not only are the systems expensive and difficult to implement, they can also tie the hands of managers. Unlike computer systems of the past, which were typically developed in-house with a company's specific requirements in mind, enterprise systems are off-the-shelf solutions. They impose their own logic on a company's strategy, culture, and organization, often forcing companies to change the way they do business. Managers would do well to heed the horror stories of failed implementations. FoxMeyer Drug, for example, claims that its system helped drive it into bankruptcy. Drawing on examples of both successful and unsuccessful ES projects, the author discusses the pros and cons of implementing an enterprise system, showing how a system can produce unintended and highly disruptive consequences. Because of an ES's profound business implications, he cautions against shifting responsibility for its adoption to technologists. Only a general manager will be able to mediate between the imperatives of the system and the imperatives of the business.

3D Systems' Technology Overview and New Applications in Manufacturing, Engineering, Science, and Education

PubMed Central

Andrews, Mike; Weislogel, Mark; Moeck, Peter; Stone-Sundberg, Jennifer; Birkes, Derek; Hoffert, Madeline Paige; Lindeman, Adam; Morrill, Jeff; Fercak, Ondrej; Friedman, Sasha; Gunderson, Jeff; Ha, Anh; McCollister, Jack; Chen, Yongkang; Geile, John; Wollman, Andrew; Attari, Babak; Botnen, Nathan; Vuppuluri, Vasant; Shim, Jennifer; Kaminsky, Werner; Adams, Dustin; Graft, John

2014-01-01

Abstract Since the inception of 3D printing, an evolutionary process has taken place in which specific user and customer needs have crossed paths with the capabilities of a growing number of machines to create value-added businesses. Even today, over 30 years later, the growth of 3D printing and its utilization for the good of society is often limited by the various users' understanding of the technology for their specific needs. This article presents an overview of current 3D printing technologies and shows numerous examples from a multitude of fields from manufacturing to education. PMID:28473997

Determination of the element-specific complex permittivity using a soft x-ray phase modulator

NASA Astrophysics Data System (ADS)

Kubota, Y.; Hirata, Y.; Miyawaki, J.; Yamamoto, S.; Akai, H.; Hobara, R.; Yamamoto, Sh.; Yamamoto, K.; Someya, T.; Takubo, K.; Yokoyama, Y.; Araki, M.; Taguchi, M.; Harada, Y.; Wadati, H.; Tsunoda, M.; Kinjo, R.; Kagamihata, A.; Seike, T.; Takeuchi, M.; Tanaka, T.; Shin, S.; Matsuda, I.

2017-12-01

We report on directly determining the complex permittivity tensor using a method combining a developed light source from a segmented cross undulator of synchrotron radiation and the magneto-optical Kerr effect. The empirical permittivity, which carries the electronic and magnetic information of a material, has element specificity and has perfect confirmation using the quantum-mechanical calculation for itinerant electrons systems. These results help in understanding the interaction of light and matter, and they provide an interesting approach to seek the best materials as optical elements, for example, in extended-ultraviolet lithographic technologies or in state-of-the-art laser technologies.

Choosing the Right Systems Integration

NASA Astrophysics Data System (ADS)

Péči, Matúš; Važan, Pavel

2014-12-01

The paper examines systems integration and its main levels at higher levels of control. At present, the systems integration is one of the main aspects participating in the consolidation processes and financial flows of a company. Systems Integration is a complicated emotionconsuming process and it is often a problem to choose the right approach and level of integration. The research focused on four levels of integration, while each of them is characterized by specific conditions. At each level, there is a summary of recommendations and practical experience. The paper also discusses systems integration between the information and MES levels. The main part includes user-level integration where we describe an example of such integration. Finally, we list recommendations and also possible predictions of the systems integration as one of the important factors in the future.

Managing Sustainable Data Infrastructures: The Gestalt of EOSDIS

NASA Technical Reports Server (NTRS)

Behnke, Jeanne; Lowe, Dawn; Lindsay, Francis; Lynnes, Chris; Mitchell, Andrew

2016-01-01

EOSDIS epitomizes a System of Systems, whose many varied and distributed parts are integrated into a single, highly functional organized science data system. A distributed architecture was adopted to ensure discipline-specific support for the science data, while also leveraging standards and establishing policies and tools to enable interdisciplinary research, and analysis across multiple scientific instruments. The EOSDIS is composed of system elements such as geographically distributed archive centers used to manage the stewardship of data. The infrastructure consists of underlying capabilities connections that enable the primary system elements to function together. For example, one key infrastructure component is the common metadata repository, which enables discovery of all data within the EOSDIS system. EOSDIS employs processes and standards to ensure partners can work together effectively, and provide coherent services to users.

Controller Synthesis for Periodically Forced Chaotic Systems

NASA Astrophysics Data System (ADS)

Basso, Michele; Genesio, Roberto; Giovanardi, Lorenzo

Delayed feedback controllers are an appealing tool for stabilization of periodic orbits in chaotic systems. Despite their conceptual simplicity, specific and reliable design procedures are difficult to obtain, partly also because of their inherent infinite-dimensional structure. This chapter considers the use of finite dimensional linear time invariant controllers for stabilization of periodic solutions in a general class of sinusoidally forced nonlinear systems. For such controllers — which can be interpreted as rational approximations of the delayed ones — we provide a computationally attractive synthesis technique based on Linear Matrix Inequalities (LMIs), by mixing results concerning absolute stability of nonlinear systems and robustness of uncertain linear systems. The resulting controllers prove to be effective for chaos suppression in electronic circuits and systems, as shown by two different application examples.

Application of polarization in high speed, high contrast inspection

NASA Astrophysics Data System (ADS)

Novak, Matthew J.

2017-08-01

Industrial optical inspection often requires high speed and high throughput of materials. Engineers use a variety of techniques to handle these inspection needs. Some examples include line scan cameras, high speed multi-spectral and laser-based systems. High-volume manufacturing presents different challenges for inspection engineers. For example, manufacturers produce some components in quantities of millions per month, per week or even per day. Quality control of so many parts requires creativity to achieve the measurement needs. At times, traditional vision systems lack the contrast to provide the data required. In this paper, we show how dynamic polarization imaging captures high contrast images. These images are useful for engineers to perform inspection tasks in some cases where optical contrast is low. We will cover basic theory of polarization. We show how to exploit polarization as a contrast enhancement technique. We also show results of modeling for a polarization inspection application. Specifically, we explore polarization techniques for inspection of adhesives on glass.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loughran, B; Singh, V; Jain, A

Purpose: Although generalized linear system analytic metrics such as GMTF and GDQE can evaluate performance of the whole imaging system including detector, scatter and focal-spot, a simplified task-specific measured metric may help to better compare detector systems. Methods: Low quantum-noise images of a neuro-vascular stent with a modified ANSI head phantom were obtained from the average of many exposures taken with the high-resolution Micro-Angiographic Fluoroscope (MAF) and with a Flat Panel Detector (FPD). The square of the Fourier Transform of each averaged image, equivalent to the measured product of the system GMTF and the object function in spatial-frequency space, wasmore » then divided by the normalized noise power spectra (NNPS) for each respective system to obtain a task-specific generalized signal-to-noise ratio. A generalized measured relative object detectability (GM-ROD) was obtained by taking the ratio of the integral of the resulting expressions for each detector system to give an overall metric that enables a realistic systems comparison for the given detection task. Results: The GM-ROD provides comparison of relative performance of detector systems from actual measurements of the object function as imaged by those detector systems. This metric includes noise correlations and spatial frequencies relevant to the specific object. Additionally, the integration bounds for the GM-ROD can be selected to emphasis the higher frequency band of each detector if high-resolution image details are to be evaluated. Examples of this new metric are discussed with a comparison of the MAF to the FPD for neuro-vascular interventional imaging. Conclusion: The GM-ROD is a new direct-measured task-specific metric that can provide clinically relevant comparison of the relative performance of imaging systems. Supported by NIH Grant: 2R01EB002873 and an equipment grant from Toshiba Medical Systems Corporation.« less

[Managment system in safety and health at work organization. An Italian example in public sector: Inps].

PubMed

Di Loreto, G; Felicioli, G

2010-01-01

The Istituto Nazionale della Previdenza Sociale (Inps) is one of the biggest Public Sector organizations in Italy; about 30.000 people work in his structures. Fifteen years ago, Inps launched a long term project with the objective to create a complex and efficient safety and health at work organization. Italian law contemplates a specific kind of physician working on safety and health at work, called "Medico competente", and 85 Inps's physicians work also as "Medico competente". This work describes how IT improved coordination and efficiency in this occupational health's management system.

A computerized compensator design algorithm with launch vehicle applications

NASA Technical Reports Server (NTRS)

Mitchell, J. R.; Mcdaniel, W. L., Jr.

1976-01-01

This short paper presents a computerized algorithm for the design of compensators for large launch vehicles. The algorithm is applicable to the design of compensators for linear, time-invariant, control systems with a plant possessing a single control input and multioutputs. The achievement of frequency response specifications is cast into a strict constraint mathematical programming format. An improved solution algorithm for solving this type of problem is given, along with the mathematical necessities for application to systems of the above type. A computer program, compensator improvement program (CIP), has been developed and applied to a pragmatic space-industry-related example.

Symbolic computer vector analysis

NASA Technical Reports Server (NTRS)

Stoutemyer, D. R.

1977-01-01

A MACSYMA program is described which performs symbolic vector algebra and vector calculus. The program can combine and simplify symbolic expressions including dot products and cross products, together with the gradient, divergence, curl, and Laplacian operators. The distribution of these operators over sums or products is under user control, as are various other expansions, including expansion into components in any specific orthogonal coordinate system. There is also a capability for deriving the scalar or vector potential of a vector field. Examples include derivation of the partial differential equations describing fluid flow and magnetohydrodynamics, for 12 different classic orthogonal curvilinear coordinate systems.

Artificial Neural Networks: an overview and their use in the analysis of the AMPHORA-3 dataset.

PubMed

Buscema, Paolo Massimo; Massini, Giulia; Maurelli, Guido

2014-10-01

The Artificial Adaptive Systems (AAS) are theories with which generative algebras are able to create artificial models simulating natural phenomenon. Artificial Neural Networks (ANNs) are the more diffused and best-known learning system models in the AAS. This article describes an overview of ANNs, noting its advantages and limitations for analyzing dynamic, complex, non-linear, multidimensional processes. An example of a specific ANN application to alcohol consumption in Spain, as part of the EU AMPHORA-3 project, during 1961-2006 is presented. Study's limitations are noted and future needed research using ANN methodologies are suggested.

Software design by reusing architectures

NASA Technical Reports Server (NTRS)

Bhansali, Sanjay; Nii, H. Penny

1992-01-01

Abstraction fosters reuse by providing a class of artifacts that can be instantiated or customized to produce a set of artifacts meeting different specific requirements. It is proposed that significant leverage can be obtained by abstracting software system designs and the design process. The result of such an abstraction is a generic architecture and a set of knowledge-based, customization tools that can be used to instantiate the generic architecture. An approach for designing software systems based on the above idea are described. The approach is illustrated through an implemented example, and the advantages and limitations of the approach are discussed.

System engineering for image and video systems

NASA Astrophysics Data System (ADS)

Talbot, Raymond J., Jr.

1997-02-01

The National Law Enforcement and Corrections Technology Centers (NLECTC) support public law enforcement agencies with technology development, evaluation, planning, architecture, and implementation. The NLECTC Western Region has a particular emphasis on surveillance and imaging issues. Among its activities, working with government and industry, NLECTC-WR produces 'Guides to Best Practices and Acquisition Methodologies' that facilitate government organizations in making better informed purchasing and operational decisions. This presentation includes specific examples from current activities. Through these systematic procedures, it is possible to design solutions optimally matched to the desired outcomes and provide a process for continuous improvement and greater public awareness of success.

Safety considerations in the design and operation of large wind turbines

NASA Technical Reports Server (NTRS)

Reilly, D. H.

1979-01-01

The engineering and safety techniques used to assure the reliable and safe operation of large wind turbine generators utilizing the Mod 2 Wind Turbine System Program as an example is described. The techniques involve a careful definition of the wind turbine's natural and operating environments, use of proven structural design criteria and analysis techniques, an evaluation of potential failure modes and hazards, and use of a fail safe and redundant component engineering philosophy. The role of an effective quality assurance program, tailored to specific hardware criticality, and the checkout and validation program developed to assure system integrity are described.

An Overview of the NASA F-18 High Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Bowers, Albion H.; Pahle, Joseph W.; Wilson, R. Joseph; Flick, Bradley C.; Rood, Richard L.

1996-01-01

This paper gives an overview of the NASA F-18 High Alpha Research Vehicle. The three flight phases of the program are introduced, along with the specific goals and data examples taken during each phase. The aircraft configuration and systems needed to perform the disciplinary and inter-disciplinary research are discussed. The specific disciplines involved with the flight research are introduced, including aerodynamics, controls, propulsion, systems, and structures. Decisions that were made early in the planning of the aircraft project and the results of those decisions are briefly discussed. Each of the three flight phases corresponds to a particular aircraft configuration, and the research dictated the configuration to be flown. The first phase gathered data with the baseline F-18 configuration. The second phase was the thrust-vectoring phase. The third phase used a modified forebody with deployable nose strakes. Aircraft systems supporting these flights included extensive instrumentation systems, integrated research flight controls using flight control hardware and corresponding software, analog interface boxes to control forebody strakes, a thrust-vectoring system using external post-exit vanes around axisymmetric nozzles, a forebody vortex control system with strakes, and backup systems using battery-powered emergency systems and a spin recovery parachute.

Photosynthetic Machineries in Nano-Systems

PubMed Central

Nagy, László; Magyar, Melinda; Szabó, Tibor; Hajdu, Kata; Giotta, Livia; Dorogi, Márta; Milano, Francesco

2014-01-01

Photosynthetic reaction centres are membrane-spanning proteins, found in several classes of autotroph organisms, where a photoinduced charge separation and stabilization takes place with a quantum efficiency close to unity. The protein remains stable and fully functional also when extracted and purified in detergents thereby biotechnological applications are possible, for example, assembling it in nano-structures or in optoelectronic systems. Several types of bionanocomposite materials have been assembled by using reaction centres and different carrier matrices for different purposes in the field of light energy conversion (e.g., photovoltaics) or biosensing (e.g., for specific detection of pesticides). In this review we will summarize the current status of knowledge, the kinds of applications available and the difficulties to be overcome in the different applications. We will also show possible research directions for the close future in this specific field. PMID:24678673

Indicator Systems and Evaluation

NASA Technical Reports Server (NTRS)

Canright, Shelley; Grabowski, Barbara

1995-01-01

Participants in the workshop session were actively engaged in a hands-on, minds-on approach to learning about indicators and evaluation processes. The six hour session was broken down into three two hour sessions. Each session was built upon an instructional model which moved from general understanding to specific IITA application. Examples and practice exercises served to demonstrate tand reinforce the workshop concepts. Each successive session built upon the previous session and addressed the major steps in the evaluation process. The major steps covered in the workshop included: project descriptions, writing goals and objectives for categories, determining indicators and indicator systems for specific projects, and methods and issues of data collection. The workshop served as a baseline upon which the field centers will build during the summer in undertaking a comprehensive examination and evaluation of their existing K-12 education projects.

Network Security Validation Using Game Theory

NASA Astrophysics Data System (ADS)

Papadopoulou, Vicky; Gregoriades, Andreas

Non-functional requirements (NFR) such as network security recently gained widespread attention in distributed information systems. Despite their importance however, there is no systematic approach to validate these requirements given the complexity and uncertainty characterizing modern networks. Traditionally, network security requirements specification has been the results of a reactive process. This however, limited the immunity property of the distributed systems that depended on these networks. Security requirements specification need a proactive approach. Networks' infrastructure is constantly under attack by hackers and malicious software that aim to break into computers. To combat these threats, network designers need sophisticated security validation techniques that will guarantee the minimum level of security for their future networks. This paper presents a game-theoretic approach to security requirements validation. An introduction to game theory is presented along with an example that demonstrates the application of the approach.