MARIKA - A model revision system using qualitative analysis of simulations. [of human orientation system

NASA Technical Reports Server (NTRS)

Groleau, Nicolas; Frainier, Richard; Colombano, Silvano; Hazelton, Lyman; Szolovits, Peter

1993-01-01

This paper describes portions of a novel system called MARIKA (Model Analysis and Revision of Implicit Key Assumptions) to automatically revise a model of the normal human orientation system. The revision is based on analysis of discrepancies between experimental results and computer simulations. The discrepancies are calculated from qualitative analysis of quantitative simulations. The experimental and simulated time series are first discretized in time segments. Each segment is then approximated by linear combinations of simple shapes. The domain theory and knowledge are represented as a constraint network. Incompatibilities detected during constraint propagation within the network yield both parameter and structural model alterations. Interestingly, MARIKA diagnosed a data set from the Massachusetts Eye and Ear Infirmary Vestibular Laboratory as abnormal though the data was tagged as normal. Published results from other laboratories confirmed the finding. These encouraging results could lead to a useful clinical vestibular tool and to a scientific discovery system for space vestibular adaptation.

An Analysis of the President’s Budgetary Proposals for Fiscal Year 2010

DTIC Science & Technology

2009-06-01

Ozanne, Frank Russek, Marika Santoro, Kurt Seibert, Sven Sinclair, and David Weiner carried out the modeling . Barry Blom of CBO’s Projections Unit...Baseline Policy Assumptions 15 Ways in Which the President’s Proposals Would Affect the Economy 15 The Models and Their Results 21 The Potential Economic...Effects of Selected Proposals in the President’s 2010 Budget 27 The Models Used to Analyze the Supply-Side Macroeconomic Effects of the President’s

Lost in the Dark: A proto-history of dark matter

NASA Astrophysics Data System (ADS)

Trimble, Virginia L.; History 1

2016-01-01

Einasto, Kaasik, and Saar (published in Nature, in case you are thinking of more Meddelande). I feel enormous respect and affection for Vera Rubin and Fritz Zwicky, but the published papers as are they are.

Final Technical Report for Project "Improving the Simulation of Arctic Clouds in CCSM3"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephen J. Vavrus

2008-11-15

greenhouse warming and the extent to which models adequately represent Arctic clouds in the modern climate. This site was used extensively in the IARC summer school projects. This work has also led to a collaboration this year during a 4-month visit I made to NCAR through its Faculty Fellowship Program. I worked with scientists Marika Holland, David Bailey, Andrew Gettleman, and Jen Kay, who are researching polar climate and/or clouds. I met with this group frequently during my visit, leading to some fruitful interactions. This work led to the discovery of a tightly coupled response of clouds and sea ice during intervals of rapid sea ice loss in greenhouse simulations, as well as advising on the evolving CCSM3.5 to CCSM4 model development. This involvement with NCAR also led to a longer-term connection, as I have recently begun a two-year stint on the SSC for CCSM.« less

Poster Session B

PubMed Central

2014-01-01

proteins which are fundamental regulators of PPARg and the fat cell commitment decision. B.6 Application of Quantitative and Functional Phosphoproteomics In Study of Ethylene Signaling Ning Li 1 1The Hong Kong University of Science and Technology, Hong Kong, China Ethylene is a major plant hormone that regulates a diverse aspect of plant growth and development. The regulatory roles of ethylene in plants include promotion of leaf and flower petal senescence, yellowing and abscission, as well as promotion of fruit abscission and ripening. This key hormone is also involved in regulation of a number of plant biotic and abiotic stress responses. A dramatic effect of ethylene on tropic response is the dual-and-opposing effect of ethylene on stem negative gravitropic response, in which short-term ethylene treatment (0.5 hour) appears to inhibit stem bending up following re-orientation of inflorescence of Arabidopsis. In contrast, a long-term treatment (12 hours) stimulates gravitropic response and promote stem curve up faster. This time-dependent and dose- independent dual-and-opposing effect of ethylene on stem gravitropism may involve multiple signaling pathways. Stable isotope metabolic labeling-based quantitative phosphoproteomics performed on ein2–5, ctr1–1 and rcn1–1 ethylene signaling mutants indeed confirmed the time-dependent protein phosphorylation changes and some of phosphorylation events are independent to ein2 loss-of- function gene in response to ethylene treatment. Functional studies on the phosphorylated transcription factor ERF110 isoform suggest that it is required for the control of flowering time via multiple ethylene signaling pathways. B.7 Intact N- and O-linked Glycopeptide Identification from HCD Data Using Byonic Katalin F. Medzihradszky1, Jason Maynard1, Krista Kaasik1, Marshall Bern2 1University of California, San Francisco, CA, USA; 2Protein Metrics, San Carlos, CA, USA The importance of high quality analysis of glycosylated proteins is steadily