Grain Refining and Microstructural Modification during Solidification.

DTIC Science & Technology

1983-10-01

was found to be insensitive to the iron concentration in the samples solidified in the levitated state but not in samples quenched from the liquid . The... liquid . The preliminary * results with niobium additions indicate that no appreciable grain refinement * is achieved when the samples are levitated in an...to the critical examination of the Cr-Ni phase diagram, by using high purity starting materials, and a containerless electromagnetic levitation

Medicare Coverage Strategies: Impact of the MMA and PBMs

PubMed Central

Antos, Joseph

2008-01-01

American Health & Drug Benefits ™ has been created to act as an ideological melting pot focusing on health and drug benefit decision makers, as well as those who may affect or may be affected by those decisions. By engaging in conversations with payors, regulators, employers, and other stakeholders, our journal hopes to enable decision makers to view the impact of benefit designs from as many perspectives as possible. Through this open dialogue, we hope that better decisions may be made, and that the greater healthcare marketplace will be positively impacted. In following our editorial mission, American Health & Drug Benefits ™ has sought thought leaders who have influenced and will continue to influence the healthcare marketplace. During a fall visit to Washington, DC, Dr. Joseph Antos was kind enough to host a visit to the American Enterprise Institute and provide his thoughts to Robert Henry, editor-in-chief, on how the Centers for Medicare & Medicaid Services (CMS) exerts its influence on drug coverage in the wake of the Medicare Modernization Act (MMA) and in the face of evidence-based medicine standards. Following a chronology of CMS's role from its inception to current events, Dr. Antos offers a lively insight into CMS's strategy and its tactical effects on the American healthcare system. PMID:25126207

Numerical investigation on the performance of fin and tube heat exchangers using rectangular vortex generators

NASA Astrophysics Data System (ADS)

Zeeshan, Mohd; Hazarika, Saheera Azmi; Nath, Sujit; Bhanja, Dipankar

2017-07-01

In the present work, a 3-D numerical investigation has been performed to explore the effect of attack angles on the thermal-hydraulic performance of fin and tube heat exchanger (FTHE) using rectangular winglet pairs (RWPs). RWPs are placed adjacent to the tubes and three attack angels are considered for the study i.e. 5°, 15° and 25°. The effect of attack angles are examined on the heat transfer characteristics as well as in pressure drop penalty with airside Reynolds number Rea ranges from 500 to 900. Two performance evaluation criteria namely PEC1 i.e. area goodness factor (j/f) and PEC2 i.e. heat transfer rate per unit fan power consumption (Q/Pf) are considered for the performance evaluation. Furthermore, MOORA method is applied to obtain the performance order of FTHE configurations by taking PEC1 and PEC2 as beneficial attributes and fan power Pf as a non-beneficial attribute, keeping equal importance to each attribute. The results show that 5° attack angle provides the better performance in terms of PEC1 as heat transfer coefficient is increased by 27.70% at Rea=500 and 32.73% at Rea=900 respectively with 13.01% increased pressure drop penalty at Rea=500 and 14.26% at Rea=900 respectively. In terms of PEC2, though the 5° attack angle provides the high values of Q/Pf factor among the 15° and 25° attack angles, but it is found insignificant to replace the baseline configuration i.e. plain fin and tube heat exchanger configuration without vortex generators. Moreover, in MOORA optimization analysis also, it is found that 5° attack angle provides the better thermal-hydraulic performance.

Mission Driven Scene Understanding: Dynamic Environments

DTIC Science & Technology

2016-06-01

the Army mission. Then, for example, helpful image cues that relate to mission activities may include time of day, current and future weather...mission.10 In other words, visual saliency also can be used to highlight key image cues that relate to Army mission activities.10 For example, an...to the Army mission. Then, for example, helpful image cues that relate to mission activities may include time of day, current and future weather

Hoengsong, ROK AFS K46, Korea. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1968-04-10

N-4t 51-53956-65,67 JILLStAtION STATION AME ANTOS NON N PERCENTAGE FREQUENCY OF OCCURRENCE Or (FROM HOURLY OBSERVATIONS) I C VISIBILITY STATUTE...34 .: .: .5 .1 . 񓺟 372. 174 46 ’ - 4q .3 .6 I.C. 1.’ .9 .3 4 55 45 324 117 - ~47 .1I . 2 I A .1 . .4 . 565 5 46’ 1a3 46/ 45 .7 i . 1.6 .9 .2 .2, 712

A Special Relationship: Bridging the NATO Intelligence Gap

DTIC Science & Technology

2013-06-01

the uncertainty of a NATO-Soviet ground war on the plains of central Europe.15 As the Soviet Union disintegrated in the early 1990s NATO faced an...intelligence process, and other nations need to contribute more to the common intelligence picture. That way we can build on that picture rapidly in an...to lead such an organization. The proliferation of mobile communication devices such as cell phones, smart phones, and tablet devices along with

Weapon Performance Testing and Analysis: The MODI-PAC Round, the Number 4 Lead-Shot Round, and the Flying Baton

DTIC Science & Technology

1976-01-01

items. The items tested were the MODI-PAC, a proprietary item of Reming)on Arms Company, a standard 12 - gauge round of No. 4 lead shot, and an...to refrain from testing this item. Therefore, the final selection of items for testing were (1) the MODI-PAC, (2) a standard 12 - gauge shotgun round of...The first item evaluated was the MODI-PAC5. The MOQ1-PAC which standsfor “modified impact “ is a 12 - gauge shotgun shell loaded with approximately 320

Dating Kaali Crater (Estonia) based on charcoal emplaced within proximal ejecta blanket

NASA Astrophysics Data System (ADS)

Losiak, Anna; Wild, Eva Maria; Huber, Matthew S.; Wisniowski, Tomasz; Paavel, Kristiina; Jõeleht, Argo; Välja, Rudolf; Plado, Jüri; Kriiska, Aivar; Wilk, Jakob; Zanetti, Michael; Geppert, Wolf D.; Kulkov, Alexander; Steier, Peter; Pirkovic, Irena

2015-04-01

The Kaali impact field consists of nine identified craters located on the Saaremaa Island in Estonia. The largest crater is 110 m in diameter (centered around 58°22'21.94"N, 22°40'09.91" E). It was formed by impact of an IAB iron meteoroid into Silurian dolomite target rocks covered by up to a few meters of glacial till (Veski et al. 2007). The age of the Kaali impact structure is still a matter of debate, and the estimates provided by different authors vary considerably between ~6400 BC (Raukas et al. 1995, Moora et al. 2012) and ~400 BC (Rasmussen et al. 2000, Veski et al. 2001). These ages were derived by 14C dating of marker horizons, characterized by a slightly elevated iridium content within the nearby Piila bog yielding a calibrated age of 800-400 BC (Rasmussen et al. 2000, Veski et al. 2001) and occurrences of glassy siliceous material in the Piila bog (~6400 BC: Raukas et al. 1995) or iron microspherules in an organic-rich layer of the Reo gravel pit (6400 BC: Moora et al. 2012). However, the source of the foreign material within those layers was never unequivocally connected with the Kaali crater. 14C dating of material from post-impact organic sediments within Kaali impact craters yielded ages between 1800-1500 BC (Saarse et al. 1991, Veski et al. 2004) and 1450-400 BC (Aaloe et al. 1963). These dates underestimate the age of impact as organic sediments within the crater started to form at unknown period after the impact. On the other hand, Veski et al. (2004) suggested a reservoir effect that might have caused artificially "aging" of the organic matter because the crater was emplaced within Silurian dolomite which is rich in old carbon. The aim of this study is to determine the age of the Kaali crater by 14C dating of organic material covered by the continuous layer of proximal ejecta. This research was conducted in conjunction with a new structural investigation of Kaali Main (Zanetti et al. 2015). Ten samples collected from different locations

A novel hybrid MCDM model for performance evaluation of research and technology organizations based on BSC approach.

PubMed

Varmazyar, Mohsen; Dehghanbaghi, Maryam; Afkhami, Mehdi

2016-10-01

Balanced Scorecard (BSC) is a strategic evaluation tool using both financial and non-financial indicators to determine the business performance of organizations or companies. In this paper, a new integrated approach based on the Balanced Scorecard (BSC) and multi-criteria decision making (MCDM) methods are proposed to evaluate the performance of research centers of research and technology organization (RTO) in Iran. Decision-Making Trial and Evaluation Laboratory (DEMATEL) are employed to reflect the interdependencies among BSC perspectives. Then, Analytic Network Process (ANP) is utilized to weight the indices influencing the considered problem. In the next step, we apply four MCDM methods including Additive Ratio Assessment (ARAS), Complex Proportional Assessment (COPRAS), Multi-Objective Optimization by Ratio Analysis (MOORA), and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) for ranking of alternatives. Finally, the utility interval technique is applied to combine the ranking results of MCDM methods. Weighted utility intervals are computed by constructing a correlation matrix between the ranking methods. A real case is presented to show the efficacy of the proposed approach. Copyright © 2016 Elsevier Ltd. All rights reserved.

Biosynthesis of antimycins with a reconstituted 3-formamidosalicylate pharmacophore in Escherichia coli.

PubMed

Liu, Joyce; Zhu, Xuejun; Seipke, Ryan F; Zhang, Wenjun

2015-05-15

Antimycins are a family of natural products generated from a hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly line. Although they possess an array of useful biological activities, their structural complexity makes chemical synthesis challenging, and their biosynthesis has thus far been dependent on slow-growing source organisms. Here, we reconstituted the biosynthesis of antimycins in Escherichia coli, a versatile host that is robust and easy to manipulate genetically. Along with Streptomyces genetic studies, the heterologous expression of different combinations of ant genes enabled us to systematically confirm the functions of the modification enzymes, AntHIJKL and AntO, in the biosynthesis of the 3-formamidosalicylate pharmacophore of antimycins. Our E. coli-based antimycin production system can not only be used to engineer the increased production of these bioactive compounds, but it also paves the way for the facile generation of novel and diverse antimycin analogues through combinatorial biosynthesis.

Observations of explosion generated PcP spectra at near-normal incidence

NASA Astrophysics Data System (ADS)

Niazi, Mansour; McLaughlin, Keith L.

1987-10-01

Short period recordings of PcP at the SRO station ANTO have been observed at epicentral distance of 13.5° from presumed underground explosions in western Kazahk, USSR. The core reflections are narrow band (0.6 to 2.4 Hz), short duration (3 sec) signals. Comparison of these near normally incident reflections to P waveforms observed at greater distances reveals that the PcP spectra are peaked with respect to the more representative P-wave spectra. The 1.2 Hz spectral peak is also observed for PcP waves recorded at 50 degrees. Corrections for frequency independent mantle Q attnuation models only increase the high frequency deficiency of the PcP spectra at frequencies above 1.2 Hz. A plausible explanation calls for finer structural features of core-mantle boundary (CMB) than hitherto suggested. The influence of small scale lateral heterogeneities, however, cannot be completely ruled out. (Mantle-core boundary, near normal PcP reflection.)

Experimental analysis of a high-speed railway bridge under Thalys trains

NASA Astrophysics Data System (ADS)

Xia, H.; De Roeck, G.; Zhang, N.; Maeck, J.

2003-11-01

In this paper dynamic experiments on the Antoing Bridge located on the high-speed railway line between Paris and Brussels are reported. The experiments were co-operatively carried out by the Northern Jiaotong University from China, the Catholic University of Leuven, the Free University of Brussels and the Belgium Railway Company NMBS-SNCB from Belgium. The bridge is composed of multi-span simply supported PC girders with spans of 50 m and U-shaped sections. The loads are the high-speed Thalys trains with articulated vehicles. The speeds of the Thalys trains were between 265 and 310 km/h. In the experiments, the dynamic responses of the bridge such as the deflections, the accelerations and the strains that were measured by a laser velocity displacement transducer accelerometers and strain gauges, respectively. Many useful results have been obtained from the analysis of the recorded data. The tests and the measured results can be a reference for the study and the design of high-speed railway bridges.

Immunofluorescence localization of dissociation supernatant and extracellular matrix components in Lytechinus pictus sectioned embryos. M.S. Thesis

NASA Technical Reports Server (NTRS)

Garciaflack, Ana Leticia

1988-01-01

Indirect immunofluorescence was used to localize specific extracellular components in embryos of the sea urchin Lytechinus pictus. Hyalin and S2 (a group of components found in the disaggregation supernatant from Strongylocentrotus purpuratus blastulae) were uniformly present at all stages (unfertilized up to 32 hr) except hyalin could not be detected at the 12 hour early blastula stage. Laminin was found in 16 cell, 32 cell, 6 hour, 18 hour, 24 hour, and 32 hour stages, with especially bright fluorescence at 18 hours. Collagen I was present at all stages (freshly fertilized up to 32 hour) except little was detected at 12 hours. Fibronectin was uniformly present in blastocoelar fibers stained with anto-collagen I and anti-fibronectin. These results were compared with those for S. purpuratus to produce an overview of the localization of specific extracellular matrix components during development of two species of sea urchins. The results set the stage for future studies that will examine the function of these components at the various developmental stages.

The Crustal Structure of the Central Anatolia (Turkey) Using Receiver Functions

NASA Astrophysics Data System (ADS)

Yelkenci, S.; Benoit, M.; Kuleli, H.; Gurbuz, C.

2005-12-01

Central Anatolia lies in a transitional region between the extensional tectonics of western Anatolia and the complex transpressional tectonics of Eastern Anatolia, and has a complicated thermal and structural history. Few studies of the crustal structure of Anatolia have been performed, however, studies of the crustal structure of Eastern Anatolia showed that crustal thicknesses were thinner than previously thought. To further investigate the crustal structure in Central Anatolia, we present results from receiver function analysis using new data from broad-band instruments. The stations were equipped with 7 broadband three-component STS-2 and 13 short period three-component S-13 sensors. These stations operated for period of one and half months between the October and November, 2002, and yielded data for ~ 40 high quality receiver functions. Additionally, receiver functions were also computed using data from permanent stations MALT, ISP, and ANTO. We applied the hk-stacking technique of Zhu and Kanamori (2000) to receiver functions to obtain the crustal thickness and Vp/Vs ratios. Furthermore, we applied a waveform modeling technique to investigate mid-crustal discontinuties previously imaged in the region. Our results compare well with refraction-based crustal thicknesses in overlapped areas.

Variations in the crustal structure beneath western Turkey

NASA Astrophysics Data System (ADS)

Saunders, Paul; Priestley, Keith; Taymaz, Tuncay

1998-08-01

We use teleseismic receiver functions to investigate the crustal structure at two locations in western Turkey using seismic data recorded on small arrays of temporary broad-band seismographs. The results from these analyses are compared with receiver function results from the GDSN station ANTO on the Anatolian Plateau in central Turkey. The crust is ~ 30 km thick in the region of western Turkey where active normal faulting reveals present-day extension in the upper crust and alkali-basaltic volcanism reveals recent extension within the subcrustal lithosphere The crust is ~ 34 km thick further east where crustal extension is still evident but less pronounced. In the Anatolian Plateau, which is not currently extending, the crust is ~ 38 km thick. The level of extension estimated from these measurements of crustal thickness implies a β -factor of ~ 1.2. This value agrees with the amount of extension estimated in the upper crust from the integrated seismic strain rate (β -factor of ~ 1.3), from surface faulting(β -factor of ~ 1.25) and from the amount of extension in the subcrustal lithosphere estimated from the volcanism (β -factor < 2), all indicating that the extension is approximately uniformly distributed vertically throughout the lithosphere. The Moho transition in this region appears to thin slightly as the degree of extension increases westwards.

Influence of deep sedimentary basins, crustal thining, attenuation, and topography on regional phases: selected examples from theEastern Mediteranean and the Caspian Sea Regions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldstein, P.; Schultz, C.; Larsen, S.

1997-07-15

Monitoring of a CTBT will require transportable seismic identification techniques, especially in regions where there is limited data. Unfortunately, most existing techniques are empirical and can not be used reliably in new regions. Our goal is to help develop transportable regional identification techniques by improving our ability to predict the behavior of regional phases and discriminants in diverse geologic regions and in regions with little or no data. Our approach is to use numerical modeling to understand the physical basis for regional wave propagation phenomena and to use this understanding to help explain observed behavior of regional phases and discriminants.more » In this paper, we focus on results from simulations of data in selected regions and investigate the sensitivity of these regional simulations to various features of the crustal structure. Our initial models use teleseismically estimated source locations, mechanisms, and durations and seismological structures that have been determined by others. We model the Mb 5.9, October 1992, Cairo Egypt earthquake at a station at Ankara Turkey (ANTO) using a two-dimensional crustal model consisting of a water layer over a deep sedimentary basin with a thinning crust beneath the basin. Despite the complex tectonics of the Eastern Mediterranean region, we find surprisingly good agreement between the observed data and synthetics based on this relatively smooth two-dimensional model.« less

Oxygen, hydrogen, and helium isotopes for investigating groundwater systems of the Cape Verde Islands, West Africa

USGS Publications Warehouse

Heilweil, V.M.; Solomon, K.D.; Gingerich, S.B.; Verstraeten, Ingrid M.

2009-01-01

Stable isotopes (??18O, ??2H), tritium (3H), and helium isotopes (3He, 4He) were used for evaluating groundwater recharge sources, flow paths, and residence times of three watersheds in the Cape Verde Islands (West Africa). Stable isotopes indicate the predominance of high-elevation precipitation that undergoes little evaporation prior to groundwater recharge. In contrast to other active oceanic hotspots, environmental tracers show that deep geothermal circulation does not strongly affect groundwater. Low tritium concentrations at seven groundwater sites indicate groundwater residence times of more than 50 years. Higher tritium values at other sites suggest some recent recharge. High 4He and 3He/4He ratios precluded 3H/3He dating at six sites. These high 3He/4He ratios (R/Ra values of up to 8.3) are consistent with reported mantle derived helium of oceanic island basalts in Cape Verde and provided end-member constraints for improved dating at seven other locations. Tritium and 3H/3He dating shows that S??o Nicolau Island's Ribeira Faj?? Basin has groundwater residence times of more than 50 years, whereas Fogo Island's Mosteiros Basin and Santo Ant??o Island's Ribeira Paul Basin contain a mixture of young and old groundwater. Young ages at selected sites within these two basins indicate local recharge and potential groundwater susceptibility to surface contamination and/or salt-water intrusion. ?? Springer-Verlag 2009.

Preliminary Results from the North Anatolian Fault Passive Seismic Experiment: Seismicity and Anisotropy

NASA Astrophysics Data System (ADS)

Biryol, C. B.; Ozacar, A.; Beck, S. L.; Zandt, G.

2006-12-01

The North Anatolian Fault (NAF) is one of the world's largest continental strike-slip faults. Despite much geological work at the surface, the deep structure of the NAF is relatively unknown. The North Anatolian Fault Passive Seismic Experiment is mainly focused on the lithospheric structure of this newly coalescing continental transform plate boundary. In the summer of 2005, we deployed 5 broadband seismic stations near the fault to gain more insight on the background seismicity, and in June 2006 we deployed 34 additional broadband stations along multiple transects crossing the main strand of the NAF and its splays. In the region, local seismicity is not limited to a narrow band near the NAF but distributed widely suggesting widespread continental deformation especially in the southern block. We relocated two of the largest events (M>4) that occurred close to our stations. Both events are 40-50km south of the NAF in the upper crust (6-9 km) along a normal fault with a strike-slip component that previously ruptured during the June 6, 2000 Orta-Cankiri earthquake (M=6.0). Preliminary analysis of SKS splitting for 4 stations deployed in 2005 indicates seismic anisotropy with delay times exceeding 1 sec. The fast polarization directions for these stations are primarily in NE-SW orientation, which remains uniform across the NAF. This direction is at a high angle to the surface trace of the fault and crustal velocity field, suggesting decoupling of lithosphere and mantle flow. Our SKS splitting observations are also similar to that observed from GSN station ANTO in central Turkey and stations across the Anatolian Plateau in eastern Turkey indicating relatively uniform mantle anisotropy throughout the region.

Assessment of Rock Slope Stability in Limestone Quarries in the Tournai's Region (Belgium) Using Structural Data

NASA Astrophysics Data System (ADS)

Tshibangu, Jean-Pierre; Deloge, K. Pierre-Alexandre; Deschamps, Benoît; Coudyzer, Christophe

The Tournais region is characterised by famous outcrops of carboniferous limestone which is mined out for cement and raw material production. The four main quarries found in the Region, i.e. Gaurain-Ramecroix, Milieu, Antoing and Lemay; are owned by the three main cement producers in Belgium: Italcimenti, Holcim and CBR. The global production of limestone is about 20 millions tons per year, giving big pits with depths up to 150 m. With the growth of the pits, the quarries are approaching each other leading to the problem of managing the reserves contained in the separating walls and their mechanical stability. The limestone deposit is composed of different seams having varying thickness, chemical com- position and even mechanical properties. The deposit has an overall horizontal dip and is intersected by two main sets of discontinuities with a spacing of about 10 m or less. It is also crossed by a set of east to west faults but the quarries are implanted in the in between areas, so to not be crossed by these faults. The layers and specially the shallow ones are characterised by a typical karstic weathering giving open or filled cavities. This paper presents the global work quarried out in order to study the stability of the Lemays quarry. First a description of the orientation and spacing of discontinuities is presented, and an attempt made to correlate to the development of weathering. Mechanical laboratory tests have been performed and a qualification of the rock mass assessed. A coupled approach is then presented using a mining planning analysis and mechanical simulation (i.e. Finite Element method).

Optimal filter parameters for low SNR seismograms as a function of station and event location

NASA Astrophysics Data System (ADS)

Leach, Richard R.; Dowla, Farid U.; Schultz, Craig A.

1999-06-01

Global seismic monitoring requires deployment of seismic sensors worldwide, in many areas that have not been studied or have few useable recordings. Using events with lower signal-to-noise ratios (SNR) would increase the amount of data from these regions. Lower SNR events can add significant numbers to data sets, but recordings of these events must be carefully filtered. For a given region, conventional methods of filter selection can be quite subjective and may require intensive analysis of many events. To reduce this laborious process, we have developed an automated method to provide optimal filters for low SNR regional or teleseismic events. As seismic signals are often localized in frequency and time with distinct time-frequency characteristics, our method is based on the decomposition of a time series into a set of subsignals, each representing a band with f/Δ f constant (constant Q). The SNR is calculated on the pre-event noise and signal window. The band pass signals with high SNR are used to indicate the cutoff filter limits for the optimized filter. Results indicate a significant improvement in SNR, particularly for low SNR events. The method provides an optimum filter which can be immediately applied to unknown regions. The filtered signals are used to map the seismic frequency response of a region and may provide improvements in travel-time picking, azimuth estimation, regional characterization, and event detection. For example, when an event is detected and a preliminary location is determined, the computer could automatically select optimal filter bands for data from non-reporting stations. Results are shown for a set of low SNR events as well as 379 regional and teleseismic events recorded at stations ABKT, KIV, and ANTO in the Middle East.

IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

PubMed Central

Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M.; Armstrong, Bruce K.; Baccarelli, Andrea A.; Beland, Frederick A.; Berrington, Amy; Bertazzi, Pier Alberto; Birnbaum, Linda S.; Brownson, Ross C.; Bucher, John R.; Cantor, Kenneth P.; Cardis, Elisabeth; Cherrie, John W.; Christiani, David C.; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A.; Dement, John M.; Douwes, Jeroen; Eisen, Ellen A.; Engel, Lawrence S.; Fenske, Richard A.; Fleming, Lora E.; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K.; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A.; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R.; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H.; Lynch, Charles F.; Lynge, Elsebeth; ‘t Mannetje, Andrea; McMichael, Anthony J.; McLaughlin, John R.; Marrett, Loraine; Martuzzi, Marco; Merchant, James A.; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E.; Monson, Richard; Nordby, Karl-Cristian; Olshan, Andrew F.; Parent, Marie-Elise; Perera, Frederica P.; Perry, Melissa J.; Pesatori, Angela Cecilia; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B.; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M.; Rushton, Lesley; Rusiecki, Jennifer A.; Rusyn, Ivan; Samet, Jonathan M.; Sandler, Dale P.; de Sanjose, Silvia; Schernhammer, Eva; Costantini, Adele Seniori; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silverman, Debra T.; Simonato, Lorenzo; Smith, Allan H.; Smith, Martyn T.; Spinelli, John J.; Spitz, Margaret R.; Stallones, Lorann; Stayner, Leslie T.; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W.; Stewart, Patricia A.; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E.; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G.; Ward, Elizabeth M.; Weinberg, Clarice R.; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia Hoar

2015-01-01

Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans. Objectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed. Discussion: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed. Conclusions: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public’s health. Citation: Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP

The Project Serapis: High Resolution Seismic Imagingof The Campi Flegrei Caldera Structure

NASA Astrophysics Data System (ADS)

Zollo, A.; Virieux, J.; Capuano, P.; Chiarabba, C.; de Franco, R.; Makris, J.; Michelini, A.; Musacchio, G.; Serapis Group

expected NE-SW and SE-NW structural trends and it has been designed to get 2D/3D images of the crustal structure at a regional scale. A denser 2D network of 35 OBSs has been deployed in the bay of Pozzuoli aimed at detecting and modeling reflected/converted waves from 1 the possible shallow to deep discontinuities beneath the Campi Flegrei caldera. The main target of this particular receiver lay-out is the detailed imaging of the magma chamber top, expected at 4-5 km depth, according to temperature measurements in wells and sparse seismic observations. About 5000 shots have been performed dur- ing the SERAPIS experiment, at an average spatial spacing of 125 m, for a total ship travel path of 620 km. All of the seismic lines have been re-sampled at least twice, using a staggered configuration, which results in a smaller source spacing (less than 65m). In the gulf of Pozzuoli the source array had a geometry of a 5x5 km grid, slightly shifted south with respect to the OBS array. Seismic signals produced by air- guns have been well detected up to 50-60 km distance and the whole Campi Flegrei, Ischia and Procida on-land networks have recorded high quality seismograms pro- duced by the gridded source array in the bay of Pozzuoli. Due to the extended and very dense source and receiver arrays used for SERAPIS, this campaign can provide an innovative contribution to the accurate reconstruction of the Campi Flegrei caldera structure and to the definition of its feeding system at depth. *SERAPIS group: Auger Emmanuel, Bernard Marie-Lise, Bobbio Antonella, Bonagura Mariateresa, Cantore Luciana, Convertito Vincenzo, D'Auria Luca, De Matteis Raffaella, Emolo Anto- nio, Festa Gaetano, Gasparini Paolo, Giberti Grazia, Herrero Andre, Improta Luigi, Lancieri Maria Flora, Nielsen Stefan, Nisii Vincenzo, Russo Guido, Satriano Clau- dio, Simini Mariella, Vassallo Maurizio, Bruno Pier Paolo, Buonocunto Ciro, Capello Marco, Del Pezzo Edoardo, Galluzzo Danilo, Gaudiosi Germana, Giuliana Alessio

The Role of Katabatic Flows and Synoptic Forcing on the Export of NO-NOX from Antarctica in the Austral Summer

NASA Astrophysics Data System (ADS)

Neff, William; Davis, Douglas

2015-04-01

2005. Breckenridge, C. J., U. Radok, C. R. Stearns, and D. H. Bromwich (1993), Katabatic winds along the Transantarctic Mountains, Wiley Online Library. Bromwich, D. H. (1989), Satellite Analysis of Antarctic Katabatic Wind Behavior Bulletin of the American Meteorological Society, 70(7), 738-749. Davis, D. D., et al. (2008), A reassessment of Antarctic plateau reactive nitrogen based on ANTO 2003 airborne and ground based measurements, Atmospheric Environment, 42(12), 2831-2848. Slusher, D. L., et al. (2010), Atmospheric chemistry results from the ANTCI 2005 Antarctic plateau airborne study, Journal of Geophysical Research-Atmospheres, 115.

Boundary Layer and Synoptic Effects on NO Concentrations at the South Pole: A Multiyear Perspective

NASA Astrophysics Data System (ADS)

Neff, William; Davis, Douglas

2015-04-01

Davis et al. (2010), virtually no other global polar site has shown the high levels of NOx that are routinely observed on the plateau during the Austral spring/summer time period, particularly as recorded at SP . Of particular note are the recent spring/summer observations at Summit Station Greenland [Van Dam et al., 2013] . These data revealed very low levels of NO (typically less than 20 pptv) and no BLD height dependence. Thus, they would appear to be consistent with the hypotheses of Davis et al. 2010, since the temperatures there were typically greater than -25C. Davis, D., G. Chen, M. Buhr, J. Crawford, D. Lenschow, B. Lefer, R. Shetter, F. Eisele, L. Mauldin, and A. Hogan (2004), South Pole NOx chemistry: an assessment of factors controlling variability and absolute levels, Atmospheric Environment, 38(32), 5375-5388. Davis, D. D., et al. (2008), A reassessment of Antarctic plateau reactive nitrogen based on ANTO 2003 airborne and ground based measurements, Atmospheric Environment, 42(12), 2831-2848. Neff, W., D. Helmig, A. Grachev, and D. Davis (2008), A study of boundary layer behavior associated with high NO concentrations at the South Pole using a minisodar, tethered balloons and sonic anemometer, Atmospheric Environment, 42(12), 2762-2779. Sjostedt, S. J., D. J. Tanner, J. E. Dibb, M. Buhr, M. Warshawsky, D. Davis, G. Chen, R. L. Mauldin, F. L. Eisele, R. Arimoto, and L. G. Huey (2004), Measurements HO2NO2 and HNO3 at South Pole during ANTCI 2003, Eos Trans. AGU, 85(47), Fall Meet. Suppl., Abstract A24A-02. Davis, D., W. Neff, J. Crawford, M. Buhr, D. Helmig, and M. Nicovitch (2010), Evidence for Rapid Photochemical Recycling of Antarctic Plateau Reactive Nitrogen, in IPY Oslo Science Conference, 8-12 June 2010, edited, Oslo Norway. Van Dam, B., D. Helmig, W. Neff, and L. Kramer (2013), Evaluation of Boundary Layer Depth Estimates at Summit Station, Greenland, Journal of Applied Meteorology and Climatology, 52(10), 2356-2362.

Status of whitebarkpine in the Greater Yellowstone Ecosystem: A step-trend analysis comparing 2004-2007 to 2008-2011

USGS Publications Warehouse

Shanahan, Erin; Irvine, Kathryn M.; Roberts, Dave; Litt, Andrea R.; Legg, Kristin; Daley, Rob; Chambers, Nina

2014-01-01

these 1,217 trees, 780 trees were infected with blister rust in both time steps. Trees with only canopy cankers made up approximately 43% (519 trees) of the total number of trees infected with blister rust at the end of the revisit time-step, while trees with only bole cankers comprised 20% (252 trees), and those with both canopy and bole cankers included 37% (446 trees) of the infected sample. A bole infection is considered to be more consequential than a canopy canker, as it compromises not only the overall longevity of the tree, but its functional capacity for reproductive output as well (Kendall and Arno 1990, Campbell and Antos 2000, McDonald and Hoff 2001, Schwandt and Kegley 2004). In addition to infection location, we also documented infection transition between the canopy and bole. Of the 780 live trees that were infected with blister rust in both time-steps, approximately 31% (242) maintained canopy cankers and 36% (281) retained bole infections at the end of the revisit time-step. Infection transition from canopy to bole occurred in 30% (234) of the revisit time-step trees while 3% (23) transitioned from bole to canopy infections during this period. Objective 3. To determine whitebark pine mortality, we resurveyed all belt transects to reassess the life status of permanently tagged trees >1.4 m tall. We compared the total number of live tagged trees recorded during monitoring transect establishment to the total number of resurveyed dead tagged trees recorded during the revisit time-step and identified all potential mortality-influencing conditions (blister rust, mountain pine beetle, fire and other). By the end of the revisit time-step, we observed a total of 975 dead tagged whitebark pine trees; using a ratio estimator, this represents a loss of approximately 20% (SE=4.35%) of the original live tagged tree population (GYWPMWG 2012). Objective 4. To investigate the proportion of live, reproducing tagged trees, we divided the total number of positively