The Waist Width of Skis Influences the Kinematics of the Knee Joint in Alpine Skiing

PubMed Central

Zorko, Martin; Nemec, Bojan; Babič, Jan; Lešnik, Blaz; Supej, Matej

2015-01-01

Recently alpine skis with a wider waist width, which medially shifts the contact between the ski edge and the snow while turning, have appeared on the market. The aim of this study was to determine the knee joint kinematics during turning while using skis of different waist widths (65mm, 88mm, 110mm). Six highly skilled skiers performed ten turns on a predefined course (similar to a giant slalom course). The relation of femur and tibia in the sagital, frontal and coronal planes was captured by using an inertial motion capture suit, and Global Navigation Satellite System was used to determine the skiers’ trajectories. With respect of the outer ski the knee joint flexion, internal rotation and abduction significantly decreased with the increase of the ski waist width for the greatest part of the ski turn. The greatest abduction with the narrow ski and the greatest external rotation (lowest internal rotation) with the wide ski are probably the reflection of two different strategies of coping the biomechanical requirements in the ski turn. These changes in knee kinematics were most probably due to an active adaptation of the skier to the changed biomechanical conditions using wider skis. The results indicated that using skis with large waist widths on hard, frozen surfaces could bring the knee joint unfavorably closer to the end of the range of motion in transversal and frontal planes as well as potentially increasing the risk of degenerative knee injuries. Key points The change in the skis’ waist width caused a change in the knee joint movement strategies, which had a tendency to adapt the skier to different biomechanical conditions. The use of wider skis or, in particular, skis with a large waist width, on a hard or frozen surface, could unfavourably bring the knee joint closer to the end of range of motion in transversal and frontal planes as well as may potentially increase the risk of degenerative knee injuries. The overall results of the abduction and

Transient Astrophysics Observatory (TAO)

NASA Astrophysics Data System (ADS)

Racusin, J. L.; TAO Team

2016-10-01

The Transient Astrophysics Observatory (TAO) is a NASA MidEx mission concept (formerly known as Lobster) designed to provide simultaneous wide-field gamma-ray, X-ray, and near-infrared observations of the sky.

Conflict and Tao.

ERIC Educational Resources Information Center

Crawford, Lyall

What can philosophical Taoism teach us about interpersonal conflict and effective approaches for dealing with it? Examination of selected portions of the R. Hendricks translation of the "Lao-Tzu" or "Te-Tao Ching," and experiences recorded in fieldnotes while a member of a Taoist commune suggest a four-point protocol for…

Cross-Country Skiing Today.

ERIC Educational Resources Information Center

Caldwell, John

This book presents changes in cross country skiing which have taken place in the last several years and is directed toward both beginning and seasoned tour skiers. Discussed are the following topics: (1) the cross-country revolution (new fiberglass skis); (2) equipment (how to choose from the new waxless touring skis); (3) care of equipment; (4)…

Myths Concerning Alpine Skiing Injuries

PubMed Central

Johnson, Robert J.; Ettlinger, Carl F.; Shealy, Jasper E.

2009-01-01

There are many commonly discussed myths about ski safety that are propagated by industry, physicians, and skiers. Through a review of the literature concerning 12 such topics, this article demonstrates that the following are untrue: (1) Broken legs have been traded for blown-out knees. (2) If you know your DIN (a slang term for release indicator value), you can adjust your own bindings. (3) Toe and heel piece settings must be the same to function properly. (4) Formal ski instruction will make you safer. (5) Very short skis do not need release bindings. (6) Spending a lot of money on children’s equipment is not worth the cost. (7) Children need plenty of room in ski boots for their growing feet. (8) If you think you are going to fall, just relax. (9) Exercise can prevent skiing injuries. (10) Lower release settings can reduce the risk of anterior cruciate ligament injury. (11) Buying new ski equipment is safer than renting. (12) Skiing is among the most dangerous of activities. It is important for the skiing public, physicians, and all those interested in improving skiing safety to verify the measures they advocate. The statements analyzed here are simply untrue and have the potential to cause harm if taken as fact by those exposed to these unsupported opinions. PMID:23015911

A Comparison between Alpine Skiing, Cross-Country Skiing and Indoor Cycling on Cardiorespiratory and Metabolic Response

PubMed Central

Stöggl, Thomas; Schwarzl, Christoph; Müller, Edith E.; Nagasaki, Masaru; Stöggl, Julia; Scheiber, Peter; Schönfelder, Martin; Niebauer, Josef

2016-01-01

Since physical inactivity especially prevails during winter months, we set out to identify outdoor alternatives to indoor cycling (IC) by comparing the metabolic and cardiorespiratory responses during alpine skiing (AS), cross-country skiing (XCS) and IC and analyse the effects of sex, age and fitness level in this comparison. Twenty one healthy subjects performed alpine skiing (AS), cross-country skiing (XCS), and IC. Oxygen uptake (VO2), total energy expenditure (EE), heart rate (HR), lactate, blood glucose and rate of perceived exertion (RPE) were determined during three 4-min stages of low, moderate and high intensity. During XCS and IC VO2max and EE were higher than during AS. At least 2½ hours of AS are necessary to reach the same EE as during one hour of XCS or IC. HR, VO2, lactate, and RPEarms were highest during XCS, whereas RPEwhole-body was similar and RPElegs lower than during AS and IC, respectively. Weight adjusted VO2 and EE were higher in men than in women while fitness level had no effect. Male, fit and young participants were able to increase their EE and VO2 values more pronounced. Both AS and XCS can be individually tailored to serve as alternatives to IC and may thus help to overcome the winter activity deficit. XCS was found to be the most effective activity for generating a high EE and VO2 while AS was the most demanding activity for the legs. Key points During cross-country skiing and indoor cycling VO2max and energy expenditure were higher than during alpine skiing Approximately 2½ hours of alpine skiing are necessary to reach the same energy expenditure of one hour of cross-country skiing or indoor cycling. Alpine skiing and cross-country skiing can be individually tailored to serve as sports alternatives in winter to activity deficit. By applying different skiing modes as parallel ski steering, carving long radii and short turn skiing, metabolic and cardiorespiratory response can be increased during alpine skiing. Male, fit and young

Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1

PubMed Central

Feld, Christine; Sahu, Peeyush; Frech, Miriam; Finkernagel, Florian; Nist, Andrea; Stiewe, Thorsten; Bauer, Uta-Maria; Neubauer, Andreas

2018-01-01

Abstract SKI is a transcriptional co-regulator and overexpressed in various human tumors, for example in acute myeloid leukemia (AML). SKI contributes to the origin and maintenance of the leukemic phenotype. Here, we use ChIP-seq and RNA-seq analysis to identify the epigenetic alterations induced by SKI overexpression in AML cells. We show that approximately two thirds of differentially expressed genes are up-regulated upon SKI deletion, of which >40% harbor SKI binding sites in their proximity, primarily in enhancer regions. Gene ontology analysis reveals that many of the differentially expressed genes are annotated to hematopoietic cell differentiation and inflammatory response, corroborating our finding that SKI contributes to a myeloid differentiation block in HL60 cells. We find that SKI peaks are enriched for RUNX1 consensus motifs, particularly in up-regulated SKI targets upon SKI deletion. RUNX1 ChIP-seq displays that nearly 70% of RUNX1 binding sites overlap with SKI peaks, mainly at enhancer regions. SKI and RUNX1 occupy the same genomic sites and cooperate in gene silencing. Our work demonstrates for the first time the predominant co-repressive function of SKI in AML cells on a genome-wide scale and uncovers the transcription factor RUNX1 as an important mediator of SKI-dependent transcriptional repression. PMID:29471413

Do Maximal Roller Skiing Speed and Double Poling Performance Predict Youth Cross-Country Skiing Performance?

PubMed Central

Stöggl, Roland; Müller, Erich; Stöggl, Thomas

2017-01-01

The aims of the current study were to analyze whether specific roller skiing tests and cycle length are determinants of youth cross-country (XC) skiing performance, and to evaluate sex specific differences by applying non-invasive diagnostics. Forty-nine young XC skiers (33 boys; 13.8 ± 0.6 yrs and 16 girls; 13.4 ± 0.9 yrs) performed roller skiing tests consisting of both shorter (50 m) and longer durations (575 m). Test results were correlated with on snow XC skiing performance (PXC) based on 3 skating and 3 classical distance competitions (3 to 6 km). The main findings of the current study were: 1) Anthropometrics and maturity status were related to boys’, but not to girls’ PXC; 2) Significant moderate to acceptable correlations between girls’ and boys’ short duration maximal roller skiing speed (double poling, V2 skating, leg skating) and PXC were found; 3) Boys’ PXC was best predicted by double poling test performance on flat and uphill, while girls’ performance was mainly predicted by uphill double poling test performance; 4) When controlling for maturity offset, boys’ PXC was still highly associated with the roller skiing tests. The use of simple non-invasive roller skiing tests for determination of PXC represents practicable support for ski clubs, schools or skiing federations in the guidance and evaluation of young talent. Key points Double poling tests on flat and uphill terrain and short duration maximal speed tests were the highest cross-country skiing predicting factors in girls and boys. Only in the boys there was an effect of maturation on the performance outcomes, pointing out that girls seem to be almost fully matured at the age of 13 in contrast to the boys. Roller skiing tests over short distance (50-m) and longer distance 225 m and 350 m are stable and valid measures and suitable for performance prediction in youth cross-country skiers. PMID:28912656

Lessons from the Tao for birthing practice.

PubMed

Overman, B

1994-06-01

The metaphysics of the Tao Te Ching, as the basic structure of the universe, is used to examine birthing as creation. Lessons from the Tao regarding cultivating naturalness are drawn upon to provide suggestions for women in preparation for birthing, as well as for the nurses and midwives who attend them. Compatibility of this metaphysical view of birthing with Rogers's and Newman's nursing theories is identified, and the importance of honoring the metaphysical and spiritual aspects of birthing in nursing practice is stressed.

Skiing Sochi

NASA Image and Video Library

2014-02-19

High res here: www.flickr.com/photos/gsfc/12640339235/in/photostream/ While Sochi is a coastal town on the Black Sea, the skiing events for the XXII Olympic Games are taking place about 40 kilometers (25 miles) inland. The venues are clustered around Krasnaya Polyana, a small town tucked between the Aibiga and Psekhako Ridges in the western Caucasus. This image—acquired by the Advanced Land Imager (ALI) on NASA’s Earth Observing-1 (EO-1) satellite on February 8, 2014—offers a view of the town and the ski facilities. The Rosa Khutor Alpine Center is the home to the downhill, snowboard, and freestyle events. The combined downhill skiing area measures about 20 kilometers (12 miles) in total, with the men’s downhill course stretching 3,500 meters (11,482 feet) and featuring a 1,075-meter (3,526 foot) change in elevation. The highest lift climbs to the summit of Rosa Peak, which rises 2,320 meters (7,612 feet). While not being used for the Olympics, the nearby Black Pyramid mountain has downhill skiing trails as well. The same steep slopes that make Rosa Peak good for skiing also elevate the risk of avalanches. To protect against falling snow, planners installed a series of gas pipes along the top of the ridge. The pipes emit bursts of oxygen and propane that create small, controlled avalanches. Event organizers also installed a series of earthen dams to steer snow away from infrastructure, and they have deployed two backhoes to the top of Aibiga Ridge to knock cornices away before they pose a risk. The Laura Cross-country Ski and Biathalon Center is located to the north on Psekhako Ridge. It includes two stadiums, each with their own start and finish zones, two track systems for skiing and biathlon, as well as shooting areas and warm-up zones. The center is named for the Laura River, a turbulent river that flows nearby. NASA Earth Observatory image by Jesse Allen and Robert Simmon, using EO-1 ALI data provided courtesy of the NASA EO-1 team. Caption by Adam

Skiing Sochi

NASA Image and Video Library

2014-02-19

While Sochi is a coastal town on the Black Sea, the skiing events for the XXII Olympic Games are taking place about 40 kilometers (25 miles) inland. The venues are clustered around Krasnaya Polyana, a small town tucked between the Aibiga and Psekhako Ridges in the western Caucasus. This image—acquired by the Advanced Land Imager (ALI) on NASA’s Earth Observing-1 (EO-1) satellite on February 8, 2014—offers a view of the town and the ski facilities. The Rosa Khutor Alpine Center is the home to the downhill, snowboard, and freestyle events. The combined downhill skiing area measures about 20 kilometers (12 miles) in total, with the men’s downhill course stretching 3,500 meters (11,482 feet) and featuring a 1,075-meter (3,526 foot) change in elevation. The highest lift climbs to the summit of Rosa Peak, which rises 2,320 meters (7,612 feet). While not being used for the Olympics, the nearby Black Pyramid mountain has downhill skiing trails as well. The same steep slopes that make Rosa Peak good for skiing also elevate the risk of avalanches. To protect against falling snow, planners installed a series of gas pipes along the top of the ridge. The pipes emit bursts of oxygen and propane that create small, controlled avalanches. Event organizers also installed a series of earthen dams to steer snow away from infrastructure, and they have deployed two backhoes to the top of Aibiga Ridge to knock cornices away before they pose a risk. The Laura Cross-country Ski and Biathalon Center is located to the north on Psekhako Ridge. It includes two stadiums, each with their own start and finish zones, two track systems for skiing and biathlon, as well as shooting areas and warm-up zones. The center is named for the Laura River, a turbulent river that flows nearby. NASA Earth Observatory image by Jesse Allen and Robert Simmon, using EO-1 ALI data provided courtesy of the NASA EO-1 team. Caption by Adam Voiland. Instrument: EO-1 - ALI Read more: earthobservatory

Effect of ski geometry on aggressive ski behaviour and visual aesthetics: equipment designed to reduce risk of severe traumatic knee injuries in alpine giant slalom ski racing

PubMed Central

Kröll, Josef; Spörri, Jörg; Gilgien, Matthias; Schwameder, Hermann; Müller, Erich

2016-01-01

Background/Aim Aggressive ski-snow interaction is characterised by direct force transmission and difficulty of getting the ski off its edge once the ski is carving. This behaviour has been suggested to be a main contributor to severe knee injuries in giant slalom (GS). The aim of the current study was to provide a foundation for new equipment specifications in GS by considering two perspectives: Reducing the ski's aggressiveness for injury prevention and maintaining the external attractiveness of a ski racer's technique for spectators. Methods Three GS ski prototypes were defined based on theoretical considerations and were compared to a reference ski (Pref). Compared to Pref, all prototypes were constructed with reduced profile width and increased ski length. The construction radius (sidecut radius) of Pref was ≥27 m and was increased for the prototypes: 30 m (P30), 35 m (P35), and 40 m (P40). Seven World Cup level athletes performed GS runs on each of the three prototypes and Pref. Kinetic variables related to the ski-snow interaction were assessed to quantify the ski's aggressiveness. Additionally, 13 athletes evaluated their subjective perception of aggressiveness. 15 sports students rated several videotaped runs to assess external attractiveness. Results Kinetic variables quantifying the ski's aggressiveness showed decreased values for P35 and P40 compared to Pref and P30. Greater sidecut radius reduced subjectively perceived aggressiveness. External attractiveness was reduced for P40 only. Conclusions This investigation revealed the following evaluation of the prototypes concerning injury prevention and external attractiveness: P30: no preventative gain, no loss in attractiveness; P35: substantial preventative gain, no significant loss in attractiveness; P40: highest preventative gain, significant loss in attractiveness. PMID:26603647

Application of deep learning in the identification of TAO

NASA Astrophysics Data System (ADS)

Wu, Cong; Jin, Jicheng

2018-03-01

Thyroid associated ophthalmopathy (TAO) is one of the most common orbital disease, it can be easily detected by the human eye in the late onset due to obvious changes in extraocular muscles. But in the early stage, it is not easy to be distinguish by doctors with eye because of subtle changes in extraocular muscles, so it is a good way to use the computer's ability to assist doctors to pre-diagnosis of TAO for follow-up treatment. In this paper, according to the routine diagnosis process of doctors, a comprehensive detection system network is proposed. The network consists of three different convolutional neural subnetwork, corresponding to three bitmaps of eye CT images .Finally, the output of three subnetwork are combined to generate final diagnostic result by the majority vote. Through the experiment, the detection system, whose recognition rata is 94.87%, has a good ability to identify the characteristics of TAO, can assist the doctor in the early diagnosis of TAO in a certain extent, so as to help early patients get timely treatment.

TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes

PubMed Central

Shrestha, Roshan L.; Tamura, Naoka; Fries, Anna; Levin, Nicolas; Clark, Joanna; Draviam, Viji M.

2014-01-01

Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. We demonstrate the aneugenic nature of chromosome–microtubule attachment defects in TAO1-depleted cells using an error-correction assay. Our model further strengthens the emerging paradigm that microtubule regulatory pathways are important for resolving erroneous kinetochore–microtubule attachments and maintaining the integrity of the genome, regardless of the spindle checkpoint status. PMID:24898139

Downhill Skiing Injuries.

PubMed

McKay, D H

1981-01-01

In brief: Lower extremity injuries are common in downhill skiing. Fifty-three percent of the skiing injuries in one study, and 81% in another, were below the knee. Twelve case reports are presented and their treatment is discussed. The author suggests that skiers undertake a physical fitness program to increase stamina and elasticity of muscles and ligaments.

Biomechanical comparison of the double-push technique and the conventional skate skiing technique in cross-country sprint skiing.

PubMed

Stöggl, Thomas; Müller, Erich; Lindinger, Stefan

2008-09-01

The aims of the study were to: (1) adapt the "double-push" technique from inline skating to cross-country skiing; (2) compare this new skiing technique with the conventional skate skiing cross-country technique; and (3) test the hypothesis that the double-push technique improves skiing speed in a short sprint. 13 elite skiers performed maximum-speed sprints over 100 m using the double-push skate skiing technique and using the conventional "V2" skate skiing technique. Pole and plantar forces, knee angle, cycle characteristics, and electromyography of nine lower body muscles were analysed. We found that the double-push technique could be successfully transferred to cross-country skiing, and that this new technique is faster than the conventional skate skiing technique. The double-push technique was 2.9 +/- 2.2% faster (P < 0.001), which corresponds to a time advantage of 0.41 +/- 0.31 s over 100 m. The double-push technique had a longer cycle length and a lower cycle rate, and it was characterized by higher muscle activity, higher knee extension amplitudes and velocities, and higher peak foot forces, especially in the first phase of the push-off. Also, the foot was more loaded laterally in the double-push technique than in the conventional skate skiing technique.

Toward the Tao of Giftedness.

ERIC Educational Resources Information Center

Richert, E. Susanne

1986-01-01

The author considers the need for a philosophical foundation for gifted education and suggests the Tao Te Ching education can reconcile the dichotomies in the field and encompass the various cognitive, affective, ethical, and esthetic taxonomies in existence. (CL)

Teaching in the Tao.

ERIC Educational Resources Information Center

Christie, Patrick

This book shares the philosophy that what a teacher learned through the martial arts form, Aikido, allowed him to look beyond aggressive acts without responding aggressively himself, viewing the student behind the angry behavior. The teacher notes that compassion works better than any form of discipline he has ever encountered in education. Tao,…

Nordic (cross-country) skiing injuries in Australia.

PubMed

Sherry, E; Asquith, J

1987-03-02

A retrospective study of 88 nordic skiing injuries from the 1984 and 1985 skiing seasons in Australia is presented. To our knowledge, this is the largest study to date of such injuries. These injuries are compared with alpine skiing injuries from the same medical clinic for the 1985 skiing season. There was a much lower incidence of injury from nordic skiing; however, when injuries did occur, they tended to be more serious than those of alpine skiing and frequently required immediate evacuation to hospital for treatment. As the nordic skier is relatively isolated from medical services, these findings need to be considered in the future planning of rescue services for such skiers.

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

50 CFR 27.33 - Water skiing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false Water skiing. 27.33 Section 27.33 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Disturbing Violations: With Vehicles § 27.33 Water skiing. When water skiing is permitted upon national wildlife refuge waters, the public will be notified under...

Translation of a Ski School Sun Safety Program to North American Ski and Snowboard Schools

PubMed Central

Walkosz, B.J.; Buller, D.B.; Andersen, P.A.; Scott, M.D.; Liu, X.; Cutter, G.R.; Dignan, M.B.

2015-01-01

Unprotected and excessive exposure to ultraviolet radiation is the primary risk factor for skin cancer. Promoting sun safety practices to children and adolescents who recreate outdoors has the potential to reduce skin cancer occurrence later in life. Go Sun Smart (GSS), a sun safety program for employees and guests of ski areas was distributed to determine if an enhanced disseminations strategy was more effective than a basic dissemination strategy at reaching parents at ski and snowboard schools. On-site observations of GSS use and surveys of 909 parents/caregivers with children enrolled in ski and snowboard schools were conducted and analyzed using techniques for clustered designs. No differences were identified by dissemination strategy. Greater implementation of GSS was associated with greater parental recall of materials but not greater sun protection practices. Greater recall of messages, regardless of level of implementation, resulted in greater sun protection practices for children. GSS effectiveness trial’s favorable findings may have been successfully translated to ski and snowboard school across the North American ski industry. Ski areas that used more of the program materials appeared to reach parents with sun safety advice and thus convinced them to take more precautions for their children. Sun safety need not be at odds with children’s outdoor recreation activities. PMID:25761916

Industry sources of trend data - skiing

Treesearch

William F., Jr. Malcolm

1980-01-01

With precious few exceptions, ski industry trend data does not exist. This paper will enumerate sources of trend data known to the author. The paper considers the probable causes of the lack of ski industry trend data and means to ameliorate the lack of trend data. Finally, the paper presents a rationale for acquiring improved ski industry trend data.

[Skiing accidents in children (author's transl)].

PubMed

Schwarzenbach, M; Röthlisberger, M; Herwig, K; Biener, K

1981-03-13

In Arosa, a coherent skiing arena, all skiing accidents were systemically recorded by the two general practitioners for 10 years. The incidence of accidents to children compared with that of adolescents and adults was of particular interest. The incidence of accidents to children has more markedly decreased. The frequency of collisions is increasing. The most common injuries to children are fractures, followed by sprains and contusions. On the other hand sprains are the most common injury to adolescents and adults, followed by fractures and an almost equal number of contusions. The dangers of skiing and the severity of the injuries are discussed. Demands are made for prevention of skiing accidents.

Snow management practices in French ski resorts

NASA Astrophysics Data System (ADS)

Spandre, Pierre; Francois, Hugues; George-Marcelpoil, Emmanuelle; Morin, Samuel

2016-04-01

Winter tourism plays a fundamental role in the economy of French mountain regions but also in other countries such as Austria, USA or Canada. Ski operators originally developed grooming methods to provide comfortable and safe skiing conditions. The interannual variability of snow conditions and the competition with international destinations and alternative tourism activities encouraged ski resorts to mitigate their dependency to weather conditions through snowmaking facilities. However some regions may not be able to produce machine made snow due to inadequate conditions and low altitude resorts are still negatively impacted by low snow seasons. In the meantime, even though the operations of high altitude resorts do not show any dependency to the snow conditions they invest in snowmaking facilities. Such developments of snowmaking facilities may be related to a confused and contradictory perception of climate change resulting in individualistic evolutions of snowmaking facilities, also depending on ski resorts main features such as their altitude and size. Concurrently with the expansion of snowmaking facilities, a large range of indicators have been used to discuss the vulnerability of ski resorts such as the so-called "100 days rule" which was widely used with specific thresholds (i.e. minimum snow depth, dates) and constraints (i.e. snowmaking capacity). The present study aims to provide a detailed description of snow management practices and major priorities in French ski resorts with respect to their characteristics. We set up a survey in autumn 2014, collecting data from 56 French ski operators. We identify the priorities of ski operators and describe their snowmaking and grooming practices and facilities. The operators also provided their perception of the ski resort vulnerability to snow and economic challenges which we could compare with the actual snow conditions and ski lift tickets sales during the period from 2001 to 2012.

78 FR 38842 - Definition of a Ski Area

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... snow sports. The definition for a ski area in Forest Service regulations at 36 CFR 251.51 implementing... skiing. Accordingly, the Department is amending the definition for a ski area in 36 CFR 251.51 to provide... area in 36 CFR 251.51 that the preponderance of revenue at a ski area derive from activities and...

Determinants of a simulated cross-country skiing sprint competition using V2 skating technique on roller skis.

PubMed

Mikkola, Jussi; Laaksonen, Marko; Holmberg, Hans-Christer; Vesterinen, Ville; Nummela, Ari

2010-04-01

The present study investigated the performance-predicting factors of a simulated cross-country (XC) skiing sprint competition on roller skis, on a slow surface. Sixteen elite male XC skiers performed a simulated sprint competition (4 x 850 m heat with a 20-minute recovery) using V2 skating technique on an indoor tartan track. Heat velocities, oxygen consumption, and peak lactate were measured during or after the heats. Maximal skiing velocity was measured by performing a 30-m speed test. Explosive and maximal force production in the upper body was determined by bench press (BP). Subjects also performed maximal anaerobic skiing test (MAST) and the 2 x 2-km double poling (DP) test. The maximal velocity of MAST (VMAST) and velocities at 3 (V3), 5 (V5), 7 (V7) mmol.L lactate levels in MAST were determined. In the 2 x 2-km test, DP economy (VO2SUBDP) and maximal 2-km DP velocity (VDP2KM) were determined. The best single performance-predicting factors for the sprint performance were VDP2KM (r = 0.73, p < 0.01), V7 (r = 0.70, p < 0.01), and VO2SUBDP (r = -0.70, p < 0.01). Faster skiers in sprint simulation had a higher absolute VO2 (L.min) (p < 0.05-0.01) during sprint heats, and higher anaerobic skiing power (VMAST, p < 0.05) and better anaerobic skiing economy (V3, V5, V7, p < 0.05-0.001) than slower skiers. Faster skiers were also stronger in BP, with regard to both absolute (p < 0.01) and relative (p < 0.05) values. In addition, anaerobic characteristics seem to be of importance at the beginning of the XC skiing sprint competition, whereas the aerobic characteristics become more important as the XC skiing sprint competition progressed. This study indicates that sprint skiers should emphasize sport-specific upper body training, and training skiing economy at high speeds.

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.

PubMed

Wu, Jia Wei; Krawitz, Ariel R; Chai, Jijie; Li, Wenyu; Zhang, Fangjiu; Luo, Kunxin; Shi, Yigong

2002-11-01

The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-beta, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding.

Extensional Volcanism of the Taos Plateau Volcanic Field, Northern Rio Grande Rift, USA: New Insights from Geologic Mapping, 40Ar/39Ar Geochronology, Geochemistry and Geophysical Modeling

NASA Astrophysics Data System (ADS)

Thompson, R. A.; Turner, K. J.; Cosca, M. A.; Drenth, B.; Grauch, V. J. S.

2016-12-01

The Pliocene Taos Plateau Volcanic Field (TPVF) is the largest volcanic field of the Rio Grande rift. Deposits of the TPVF are distributed across 4500 km2 in the southern part of the 11,500 km2 San Luis Valley in southern Colorado and northern New Mexico constituting a major component of the structural San Luis Basin (SLB) fill. Exposed deposit thicknesses range from a few meters near the distal termini of basaltic lava flows to 240 m in the Rio Grande gorge near Taos, NM. New geologic mapping and 100 high-resolution 40Ar/39Ar age determinations help identify a complex distribution of >50 exposed eruptive centers ranging in composition from basalt to rhyolite. Total eruptive volume, estimated from geologic map relations, geophysical modeling of basin geometry and subsurface distribution of basaltic deposits, are approximately 300 km3; comprising 66% Servilleta Basalt (tholeiite), 3% mildly alkaline trachybasalt & trachyandesite, 12% olivine andesite, 17% dacite, and <1% rhyolite. Servilleta Basalt is preserved throughout the TPVF, ranging in age from 5.3 Ma to 2.95 Ma; maximum thickness is exposed in the Rio Grande gorge in association with the largest Pliocene sub-basin in the valley, the Taos graben. Smaller volume basalt centers as young as 2.9 Ma are spatially associated with monogenetic trachybasalt and trachyandesite centers ( 4.3 Ma to 2.8 Ma) along the uplifted footwall of a western fault-bounded sub-basin, the Las Mesitas graben. The plateau surface underlain primarily by Servilleta Basalt is punctuated by large ( 15 km3 erupted volume typical) monogenetic andesitic shield volcanoes ( 5-4.4 Ma); north-south aligned and distributed along the central axis of the SLB, parallel to major intrabasin faults. Large (up to 21 km3 erupted volume) zoned dacitic lava dome complexes ( 5 Ma Guadalupe Mountain/Cerro Negro, 3.9 Ma Ute Mountain, and 3 Ma San Antonio Mountain) reach elevations of 3300 m, 770 m above the valley floor each spatially and temporally associated

Crossing physical simulations of snow conditions and a geographic model of ski area to assess ski resorts vulnerability

NASA Astrophysics Data System (ADS)

François, Hugues; Spandre, Pierre; Morin, Samuel; George-Marcelpoil, Emmanuelle; Lafaysse, Matthieu; Lejeune, Yves

2016-04-01

In order to face climate change, meteorological variability and the recurrent lack of natural snow on the ground, ski resorts adaptation often rely on technical responses. Indeed, since the occurrence of episodes with insufficient snowfalls in the early 1990's, snowmaking has become an ordinary practice of snow management, comparable to grooming, and contributes to optimise the operation of ski resorts. It also participates to the growth of investments and is associated with significant operating costs, and thus represents a new source of vulnerability. The assessment of the actual effects of snowmaking and of snow management practices in general is a real concern for the future of the ski industry. The principal model use to simulate snow conditions in resorts, Ski Sim, has also been moving this way. Its developers introduced an artificial input of snow on ski area to complete natural snowfalls and considered different organisations of ski lifts (lower and upper zones). However the use of a degree-day model prevents them to consider the specific properties of artificial snow and the impact of grooming on the snowpack. A first proof of concept in the French Alps has shown the feasibility and the interest to cross the geographic model of ski areas and the output of the physically-based reanalysis of snow conditions SAFRAN - Crocus (François et al., CRST 2014). Since these initial developments, several ways have been explored to refine our model. A new model of ski areas has been developed. Our representation is now based on gravity derived from a DEM and ski lift localisation. A survey about snow management practices also allowed us to define criteria in order to model snowmaking areas given ski areas properties and tourism infrastructures localisation. We also suggest to revisit the assessment of ski resort viability based on the "one hundred days rule" based on natural snow depth only. Indeed, the impact of snow management must be considered so as to propose

Repression of endogenous Smad7 by Ski.

PubMed

Denissova, Natalia G; Liu, Fang

2004-07-02

The Ski protein has been proposed to serve as a corepressor for Smad4 to maintain a transforming growth factor-beta (TGF-beta)-responsive promoter at a repressed, basal level. However, there have been no reports so far that it indeed acts on a natural promoter. We have previously cloned the human Smad7 promoter and shown that it contains the 8-base pair palindromic Smad-binding element (SBE) necessary for TGF-beta induction. In this report, we have characterized the negative regulation of Smad7 promoter basal activity by Ski. We show that Ski inhibits the Smad7 promoter basal activity in a SBE-dependent manner. Mutation of the SBE abrogates the inhibitory effect of Ski on the Smad7 promoter. Moreover, mutation of the SBE increases the Smad7 promoter basal activity. Using the chromatin immunoprecipitation assay, we further show that Ski together with Smad4 binds to the endogenous Smad7 promoter. Finally, we show that RNAi knockdown of Ski increases Smad7 reporter gene activity in transient transfection assays as well as elevating the endogenous level of Smad7 mRNA. Taken together, our results provide the first evidence that Ski is indeed a corepressor for Smad4, which can inhibit a natural TGF-beta responsive gene at the basal state.

Translation of a Ski School Sun Safety Program to North American Ski and Snowboard Schools.

PubMed

Walkosz, Barbara J; Buller, David B; Andersen, Peter A; Scott, M D; Liu, X; Cutter, G R; Dignan, M B

2015-07-01

Health promotion programs that develop and implement strategies to promote sun safety practices to children have the potential to reduce skin cancer occurrence later in life. Go Sun Smart (GSS), a sun safety program for employees and guests of ski areas, was distributed to determine if an enhanced dissemination strategy was more effective than a basic dissemination strategy at reaching parents at ski and snowboard schools. On-site observations of GSS use and surveys of 909 parents/caregivers with children enrolled in ski and snowboard schools at 63 ski areas were conducted and analyzed using techniques for clustered designs. No differences were identified by dissemination strategy. Greater implementation of GSS (>5 messages posted) was associated with greater parental recall, 36.6% versus 16.7%, of materials, but not greater sun protection practices. Greater recall of messages, regardless of level of implementation, resulted in greater sun protection practices including applying sunscreen (p < .05), providing sunglasses and goggles (p < .01), and more use of all sun protection practices (p < .01). Ski areas with more program materials appeared to reach parents with sun safety advice and thus convinced them to take more precautions for their children. Sun safety need not be at odds with children's outdoor recreation activities. © 2015 Society for Public Health Education.

Identification of Ski as a target for Aurora A kinase

PubMed Central

Mosquera, Jocelyn; Armisen, Ricardo; Zhao, Hong Ling; Rojas, Diego A.; Maldonado, Edio; Tapia, Julio C; Colombo, Alicia; Hayman, Michael J; Marcelain, Katherine

2011-01-01

Ski is a negative regulator of the transforming growth factor-β and other signalling pathways. The absence of SKI in mouse fibroblasts leads to chromosome segregation defects and genomic instability, suggesting a role for Ski during mitosis. At this stage, Ski is phosphorylated but to date little is known about the kinases involved in this process. Here, we show that Aurora A kinase is able to phosphorylate Ski in vitro. In vivo, Aurora A and Ski co-localized at the centrosomes and co-immunoprecipitated. Conversely, a C-terminal truncation mutant of Ski (SkiΔ491–728) lacking a coiled-coil domain, displayed decreased centrosomal localization. This mutant no longer co-immunoprecipitated with Aurora-A in vivo, but was still phosphorylated in vitro, indicating that the Ski-Aurora A interaction takes place at the centrosomes. These data identify Ski as a novel target of Aurora A and contribute to an understanding of the role of these proteins in the mitotic process. PMID:21600873

Drosophila gene tao-1 encodes proteins with and without a Ste20 kinase domain that affect cytoskeletal architecture and cell migration differently

PubMed Central

Pflanz, Ralf; Voigt, Aaron; Yakulov, Toma; Jäckle, Herbert

2015-01-01

Tao-1, the single representative of the Sterile 20 kinase subfamily in Drosophila, is best known for destabilizing microtubules at the actin-rich cortex, regulating the cytoskeletal architecture of cells. More recently, Tao-1 was shown to act in the Salvador–Warts–Hippo pathway by phosphorylating Hippo, regulating cell growth as well as cell polarity. Here, we show that tao-1 encodes two proteins, one with the Sterile 20 kinase domain (Tao-L) and one without it (Tao-S), and that they act in an antagonistic manner. Tao-L expression causes lamellipodia-like cell protrusions, whereas Tao-S expression results in filopodia-like structures that make cells stick to the surface they attach to. Ectopic Tao-1 expression in the anterior region of Drosophila embryos results in pole cell formation as normally observed at the posterior end. Tao-S expression causes primordial germ cells (PGCs) to adhere to the inner wall of the gut primordia and prevents proper transepithelial migration to the gonads. Conversely, RNAi knockdowns of Tao-1 cause disordered migration of PGCs out of the gut epithelium, their dispersal within the embryo and cell death. The results reveal a novel function of Tao-1 in cell migration, which is based on antagonistic activities of two proteins encoded by a single gene. PMID:25589578

Utah ski patrol: assessing training types and resources.

PubMed

Sagalyn, Emily B; McDevitt, Marion C; Ernst, Ryan

2014-12-01

Skiers and snowboarders incur a variety of injuries and medical emergencies each year at ski resorts. The ski patrol is primarily responsible for initial triage, assessment and stabilization of these problems. The purpose of this study was to subjectively evaluate the type of training, resources, and equipment available to local ski patrols within Utah. Ski patrol directors at ski resorts in Utah were asked to complete a voluntary computerized survey. Of the 14 ski areas in Utah, ski patrol directors representing 8 resorts responded. The majority of patrols in Utah use Outdoor Emergency Care (OEC) as their primary education and certification source. Most programs also include site-specific training in addition to basic certification. All responding resorts had basic first responder equipment, including splinting devices, basic airway management, and hemorrhage control. Six of 8 responding resorts had affiliated clinics, and all had access to aeromedical transport. All of the responding ski patrol directors believed the current training level was adequate. Utah area ski patrollers frequently see trauma-related injuries and have the resources to assess and provide initial immobilization techniques. Many resorts have affiliated clinics with advanced providers, and all have access to aeromedical support to rapidly transfer patients to trauma centers. Medical directors may be of use for training as well as developing extended scope of practice protocols for advanced airway use or medication administration. Patrols may benefit from additional resort-specific training that addresses other frequently seen injuries or illnesses. Copyright © 2014 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Alpine Skiing in the Classroom

ERIC Educational Resources Information Center

Mendez-Gimenez, Antonio; Fernandez-Rio, Javier

2012-01-01

Many students settle indoors in the winter. However, this does not mean that winter should be a period of time with no physical activity. Several snow activities could be practiced during those months, such as ice-skating, ice-hockey, snowshoeing, cross-country skiing, alpine skiing, or snowboarding. In order to counteract the tendency for…

Investigations on socio economic indicators of French Alps ski industry from an explicit spatial modelling of managed snow on ski slopes

NASA Astrophysics Data System (ADS)

Spandre, Pierre; François, Hugues; Morin, Samuel; George-Marcelpoil, Emmanuelle; Lafaysse, Matthieu

2017-04-01

Investigations of the capacity of ski resorts to anticipate, cope with and recover from the impact of natural snow scarcity through snow management (grooming, snowmaking) have been realized in most of the major regions in terms of international ski offer although not in the French Alps hitherto. The present work therefore introduces an innovative approach for the investigation of socio economic implications of changes in snow conditions for the French Alps ski resorts based on a panel of 129 resorts representing 96% of the total French Alps ski lifts infrastructures. We integrated detailed spatial representations of ski resorts (including priority areas for snowmaking equipment) along with physically based snowpack modelling (including the physical impact of grooming and snowmaking). The viability of ski resorts was further adressed thanks to a commonly used rule based on the snow season duration at the village and ski lifts average elevations along with the development of original viability indicators of snow conditions in the French Alps ski resorts based on the specific periods for the economic success of winter sports: Christmas and February school holidays. Such indicators were correlated to the number of ski lifts tickets sales over the 2001 - 2014 period and proved to be relevant to investigate and predict the evolutions of ski lifts tickets sales under the current ski market conditions in the French Alps. Our results outlined the contrast of snow conditions between French Alps ski resorts, even when accounting for snow management, particularly regarding the geographical location of resorts (Southern versus Northern Alps), the size and related elevation range of ski resorts. Our physically based approach also allowed to compute the water and energy requirements for the production of Machine Made snow since the start of the development of snowguns in the French Alps. Our computations proved to be strongly correlated to the observed amounts of water from the

[Ski and SnoN: antagonistic proteins of TGFbeta signaling].

PubMed

Vignais, M L

2000-02-01

Ski and SnoN are two proto-oncogenes that, at high cellular concentrations, are associated with tumors. Up to now, apart the fact that SnoN and Ski were known to bind to DNA indirectly, very little was known about the mechanism which enables these factors to induce tumorigenesis. We know now that SnoN and Ski interact with the SMAD proteins which are mediators of TGFbeta signaling. These SMADs enable recruitment to target gene promoters of SnoN and Ski as well as the histone deacetylase activity which is associated with them. Whereas physiologic concentrations of SnoN and Ski allow a feedback regulation of TGFbeta signaling, deregulation of SnoN or Ski expression leads to total inhibition of TGFbeta signaling and of the tumor suppressors Smad2 and Smad4, which can explain the role of SnoN and Ski as oncogenes.

[Skiing injuries in school sport and possibilioties to prevent them].

PubMed

Greier, K

2011-12-01

Tyrol (Austria) is one of the regions which pioneered skiing. Skiing is considered as a national sport and is deeply rooted within the school system. Thus most pupils partake in skiing courses in this period. It is clear that such a large group of pupils also leads to a significant number of skiing injuries. Preventive issues may be derived from an analysis of the pattern and circumstances of skiing injuries. During a period of ten years (2000 - 2009) 1522 school sports injuries have been reported to the health insurance agency (Allgemeine Unfallversicherungsanstalt) from all secondary schools in Tyrol. The major disciplines were ski (48 %, n = 734) ice skateing (23 %, n = 349) and snowboard injuries (21 %, n = 315), followed by tobogganing (6 %, n = 91), cross-country skiing (1 %, n = 17) and other wintersports (1 %, n = 16). Fractures (31 %) dominated in skiing, followed by contusions (23 %), and sprains (22 %). In the analysis of the distribution of injuries during alpine skiing accidents, lower extremity injuries (39 %) dominated followed by upper extremity injuries (34 %). Head and spine injuries (13 %) were rare. Analysing the circumstances of the injuries, most injuries during skiing occurred without person to person collision (82 %), 81 % either shortly before lunch-break or in the afternoon. Skiing injuries account for a significant proportion of all school sport-related injuries in Tyrol. Lower extremity injuries account for the vast majority of all injuries. Overestimation and overtiredness may be responsible for skiing sport injuries. Preventive measures such as a fitness training (e. g., skiing exercises) prior to skiing courses, appropriate breaks and proper protective gear (i. e., helmet and spine protector) may reduce the injury rate in skiing school sport. © Georg Thieme Verlag KG Stuttgart · New York.

Favourable Changes of the Risk-Benefit Ratio in Alpine Skiing

PubMed Central

Burtscher, Martin; Ruedl, Gerhard

2015-01-01

During the past five decades recreational alpine skiing has become increasingly safer. The numerous annual media reports on ski injuries have to be interpreted on the basis of the tremendous numbers of skiers. These favourable changes seem primarily be due to the introduction of short carving skis, more rigid and comfortable ski boots, the use of protective gear like helmets, and the optimized preparation of ski slopes. The associated health benefits from skiing, especially arising from its association with a healthier life style, and possibly also from effects related to hypoxia preconditioning and increasing subjective vitality by natural elements clearly outweigh the health hazards. Technical improvements will likely help further reducing the injury risk. At least hypothetically, each individual skier could help to prevent injuries by the development of an appropriate physical fitness and responsible behaviour on ski slopes thereby optimizing the risk-benefit ratio of alpine skiing. PMID:26035659

Biomechanics research in ski jumping, 1991-2006.

PubMed

Schwameder, Hermann

2008-01-01

In this paper, I review biomechanics research in ski jumping with a specific focus on publications presented between 1991 and 2006 on performance enhancement, limiting factors of the take-off, specific training and conditioning, aerodynamics, and safety. The first section presents a brief description of ski jumping phases (in-run, take-off, early flight, stable flight, and landing) regarding the biomechanical and functional fundamentals. The most important and frequently used biomechanical methods in ski jumping (kinematics, ground reaction force analyses, muscle activation patterns, aerodynamics) are summarized in the second section. The third section focuses on ski jumping articles and research findings published after the establishment of the V-technique in 1991, as the introduction of this technique has had a major influence on performance enhancement, ski jumping regulations, and the construction of hill profiles. The final section proposes topics for future research in the biomechanics of ski jumping, including: take-off and early flight and the relative roles of vertical velocity and forward somersaulting angular momentum; optimal jumping patterns utilizing the capabilities of individual athletes; development of kinematic and kinetic feedback systems for hill jumps; comparisons of simulated and hill jumps; effect of equipment modifications on performance and safety enhancement.

Motor abilities and anthropometrics in youth cross-country skiing.

PubMed

Stöggl, R; Müller, E; Stöggl, T

2015-02-01

The purposes were to validate whether general motor abilities and anthropometrics are determinants of youth cross-country (XC) skiing performance; evaluate gender-specific differences; and to establish noninvasive diagnostics. Fifty-one youth XC skiers (34 boys; 13.8 ± 0.6 years and 17 girls; 13.4 ± 0.9 years) performed motor skill and laboratory tests, and anthropometric data were collected and correlated with XC skiing performance. Anthropometrics and maturity status were related to boys but not to girls XC skiing performance. Push-ups and 20-m sprint were correlated to XC skiing performance in both boys and girls. XC skiing performance of boys was predominantly influenced by upper body and trunk strength capacities (medicine ball throw, push-ups, and pull-ups) and jumping power (standing long and triple jump), whereas XC skiing of girls was mainly influenced by aerobic capacities (3000-m run). Laboratory measures did not reveal greater correlations to XC skiing performance compared with simple test concepts of speed, strength, and endurance. Maturity was a major confounding variable in boys but not girls. Use of noninvasive simple test concepts for determination of upper body strength, speed, and endurance represent practicable support for ski clubs, schools, or skiing federations in the guidance and evaluation of young talent, being aware of the effect of maturity especially in boys. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Alpine skiing injuries. A nine-year study.

PubMed Central

Davidson, T M; Laliotis, A T

1996-01-01

Injury patterns in alpine skiing have changed over time as ski, boot, binding, and slope-grooming technologies have evolved. We retrospectively examined injury patterns in alpine skiers over a 9-year period at the Mammoth and June mountains (California) ski area. A total of 24,340 injuries were reported for the 9 seasons studied, and total lift tickets sold numbered 9,201,486. The overall injury rate was 2.6 injuries per 1,000 skier days and increased slowly over the period studied. The knee was the most frequently injured area at 35% of all injuries. Increasing trends (P < .05) were noted for the rates of lower extremity injuries (37%) and knee injuries (45%). A decreasing trend was noted for the rate of lacerations (31% decrease). Slight increases were noted in upper extremity and axial injury rates. Skiing injuries continue to be a worrisome recreational problem despite improvements in ski equipment and slope-grooming techniques. The increasing trend in lower extremity, particularly knee, injury rates highlights the need for continued skier education and equipment innovation. PMID:8732730

Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling.

PubMed

Ueki, Nobuhide; Hayman, Michael J

2003-08-29

The oncoprotein Ski represses transforming growth factor (TGF)-beta signaling in an N-CoR-independent manner. However, the molecular mechanism(s) underlying this event has not been elucidated. Here, we identify an additional domain in Ski that mediates interaction with Smad3 which is important for this repression. This domain is distinct from the previously reported N-terminal Smad3 binding domain in Ski. Individual alanine substitution of several residues in the domain significantly affected Ski-Smad3 interaction. Furthermore, combined mutations within this domain, together with those in the previously identified Smad3 binding domain, can completely abolish the interaction of Ski with Smad3, while mutation in each domain alone retained partial interaction. By introducing those mutations that abolish direct interaction with Smad3 or Smad4 individually, or in combination, we show that interaction of Ski with either Smad3 or Smad4 is sufficient for Ski-mediated repression of TGF-beta signaling. Furthermore our results clearly demonstrate that Ski does not disrupt Smad3-Smad4 heteromer formation, and recruitment of Ski to the Smad3/4 complex through binding to either Smad3 or Smad4 is both necessary and sufficient for repression.

SkiSim - A semi-distributed model to assess the impact of climate change on ski season length and snowmaking

NASA Astrophysics Data System (ADS)

Steiger, R.

2009-04-01

Winter tourism is highly sensitive to climate change. The altitudinally- dependent line of natural snow reliability (e.g. Abegg et al. 2007) is losing its relevance for skilift operators, as for example in Tyrol 70% of the ski slopes are already covered by technical snow production. Less snowfall at lower altitudes and rising temperatures increase the demand for technical snow. Simultaneously, periods cold enough for snowmaking will get shorter and less frequent. Studies incorporating snowmaking are still rare and there is need for an assessment of the suitability of snowmaking as a successful adaptation strategy. The aim of this study is to assess the development of ski season lengths and snowmaking requirements under different climate change scenarios for ski areas in North and South Tyrol. A semi-distributed ski season model "SkiSim" was developed based on the temperature-index snow model of Kleindienst (2000) and the ski season model of Scott et al. (2007). As input variables only daily minimum and maximum temperature and precipitation are needed. Additionally, measured snowfall and snow depth are used for the calibration of the snowfall temperature at each climate station. Further snow model parameters (e.g. degree-day factor, snow metamorphosis) were adopted from Kleindienst (2000) and tested at all stations. Snowmaking module parameters were derived from interviews with ski area managers based on the methodology of Scott et al. (2007). Daily data (1960-2100) of the high resolution climate model REMO (10x10km) was used to produce climate change scenarios for four time horizons (2020s, 2030s, 2050s, 2080s) under two emission scenarios (A1B and B1). The climate change signal for change in temperature, (in standard deviation of temperature, in precipitation and in dry and wet spells) was processed on climate station data by the LARS weather generator. In winter (DJF), the change signal for daily average temperature from the 2020s to 2080s compared to 1971

Numerical investigation of the early flight phase in ski-jumping.

PubMed

Gardan, N; Schneider, A; Polidori, G; Trenchard, H; Seigneur, J M; Beaumont, F; Fourchet, F; Taiar, R

2017-07-05

The purpose of this study is to develop a numerical methodology based on real data from wind tunnel experiments to investigate the effect of the ski jumper's posture and speed on aerodynamic forces in a wide range of angles of attack. To improve our knowledge of the aerodynamic behavior of the ski jumper and his equipment during the early flight phase of the ski jump, we applied CFD methodology to evaluate the influence of angle of attack (α=14°, 21.5°, 29°, 36.5° and 44°) and speed (u=23, 26 and 29m/s) on aerodynamic forces in the situation of stable attitude of the ski jumper's body and skis. The standard k-ω turbulence model was used to investigate both the influence of the ski jumper's posture and speed on aerodynamic performance during the early flight phase. Numerical results show that the ski jumper's speed has very little impact on the lift and drag coefficients. Conversely, the lift and drag forces acting on the ski jumper's body during the early flight phase of the jump are strongly influenced by the variations of the angle of attack. The present results suggest that the greater the ski jumper's angle of inclination, with respect to the relative flow, the greater the pressure difference between the lower and upper parts of the skier. Further studies will focus on the dependency of the parameters with both the angle of attack α and the body-ski angle β as control variables. It will be possible to test and optimize different ski jumping styles in different ski jumping hills and investigate different environmental conditions such as temperature, altitude or crosswinds. Copyright © 2017 Elsevier Ltd. All rights reserved.

Wetlands and ski resorts in the French Alps: main issues and innovative ideas for the preservation of wetlands in ski areas

NASA Astrophysics Data System (ADS)

Gaucherand, S.; Evette, A.; François, H.; Paccard, P.; Perretier, C.; Wlerick, L.

2009-04-01

This presentation is a synthesis of a symposium held last October in Cemagref, Grenoble with contributions from scientists as well as lift operators, NGO's, and administrations. In the context of global change, ski resorts must rethink their development models. The diversification of the touristic offer is encouraged and the specificity of the mountain territory is at the heart of a sustainable development. In this context, the preservation of interesting and fragile habitats such as wetlands is topical. Wetlands have many recognized functions: flooding reduction, water remediation, fertilization, biodiversity conservation… In mountain areas, wetlands are small and scattered. They are of special interest in particular for their role in biodiversity conservation and for their cultural and recreational benefits. However, in ski areas, wetlands can interact with the ski activity. Indeed, wetlands can speed up snow melting in spring and they often occupy ledges, which are strategic positions for the establishment of ski resort's facilities. The development of ski resorts can lead to the destruction or the deterioration of wetlands because of hydrologic interferences, fill in, pollution, etc. However, a few judicious steps can be taken to reduce or suppress these negative effects. In the Alps, geographical and administrative tools have been developed to help the decisions of ski-resort's administrators. Meetings between lift-operators, administrators of protected areas scientists and NGO's have also proved efficient when done at an early stage of a project, as shown by the example of the ski-resort "Les Saisies".

78 FR 21343 - New Ski Area Water Rights Clause

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... DEPARTMENT OF AGRICULTURE Forest Service New Ski Area Water Rights Clause AGENCY: Forest Service... initial public input on a new water rights clause for ski area permits issued by the Forest Service. There... comments and suggestions that the Forest Service will consider in developing a new ski area water rights...

Chemical exposure among professional ski waxers--characterization of individual work operations.

PubMed

Freberg, Baard Ingegerdsson; Olsen, Raymond; Thorud, Syvert; Ellingsen, Dag G; Daae, Hanne Line; Hersson, Merete; Molander, Paal

2013-04-01

Preparation of skis prior to skiing competitions involves several individual work operations and the use of a wide variety of chemically based ski waxing products to improve the performance of the skis, including products used after skiing for wax removal and ski sole cleaning. Modern ski waxes consist mainly of petroleum-derived straight-chain aliphatic hydrocarbons, perfluoro-n-alkanes or polyfluorinated n-alkanes. The wax cleaning products contain solvents such as neat aliphatic hydrocarbons (aliphates) or a mixture with limonene. Different ski waxing work operations can result in contaminated workroom atmospheres. The aim of this study was to assess the chemical exposures related to the individual ski waxing work operations by investigating the specific work operations in controlled model experiments. Four main work operations with potential exposures were identified: (i) application of glider waxes, (ii) scraping and brushing of applied glider waxes, (iii) application of base/grip waxes, and (iv) ski sole cleaning. Aerosol particle masses were sampled using conical samplers equipped with 37-mm PVC, 5-µm pore size filters and cyclones equipped with 37-mm PVC, 0.8-µm pore size filters for the inhalable and the respirable aerosol mass fractions, respectively. For measurements of particle number concentrations, a Scanning Mobility Particle Sizer was used. Mean aerosol particle mass concentrations of 18.6 mg m(-3) and 32.2 mg m(-3) were measured during application of glider wax powders in the respirable and in the inhalable aerosol mass fractions, respectively. Particle number concentration of ~900 000 particles cm(-3) was measured during application of glider wax powder products. Ski sole cleaning with products containing aliphates displayed solvent air concentrations up to 62.5 p.p.m. This study shows that the potential exposure to generated particles during ski waxing and ski preparation is considerable, especially during work using glide wax powders.

Characterization of chicken c-ski oncogene products expressed by retrovirus vectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutrave, P.; Copeland, T.D.; Hughes, S.H.

1990-06-01

The authors have constructed replication-competent avian retrovirus vectors that contain two of the three known types of chicken c-{ital ski} cDNAs and a third vector that contains a truncated c-{ital ski} cDNA. They developed antisera that recognize the c-{ital ski} proteins made by the three transforming c-{ital ski} viruses. All three proteins (apparent molecular masses, 50, 60, and 90 kilodaltons) are localized primarily in the nucleus. The proteins are differentially phosphorylated; immunofluorescence also suggests that there are differences in subnuclear localization of the c-{ital ski} proteins and that c-{ital ski} protein is associated with condensed chromatin in dividing cells.

"no snow - no skiing excursion - consequences of climatic change?"

NASA Astrophysics Data System (ADS)

Neunzig, Thilo

2014-05-01

Climatology and climate change have become central topics in Geography at our school. Because of that we set up a climatological station at our school. The data are an important basis to observe sudden changes in the weather. The present winter (2013/2014) shows the importance of climate change in Alzey / Germany. In winter many students think of the yearly skiing trip to Schwaz / Austria which is part of our school programme. Due to that the following questions arise: Will skiing still be possible if climate change accelerates? How are the skiing regions in the Alpes going to change? What will happen in about 20 years? How does artificial snow change the landscape and the skiing sport? Students have to be aware of the ecological damage of skiing trips. Each class has to come up with a concept how these trips can be as environmentally friendly as possible. - the trip is for a restricted number of students only (year 8 only) - a small skiing region is chosen which is not overcrowded - snow has to be guaranteed in the ski area to avoid the production of artificial snow (avoidance of high water consumption) - the bus arrives with a class and returns with the one that had been there before These are but a few ideas of students in order to make their trip as environmentally friendly as possible. What is missing is only what is going to happen in the future. What will be the effect of climate change for skiing regions in the secondary mountains? How is the average temperature for winter going to develop? Are there possibilities for summer tourism (e.g. hiking) instead of skiing in winter? The students are going to try to find answers to these questions which are going to be presented on a poster on the GIFT-Workshop in Vienna.

14 CFR 27.505 - Ski landing conditions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ski landing conditions. 27.505 Section 27.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 27.505 Ski landing...

14 CFR 29.505 - Ski landing conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Ski landing conditions. 29.505 Section 29.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 29.505 Ski landing...

14 CFR 27.505 - Ski landing conditions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Ski landing conditions. 27.505 Section 27.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 27.505 Ski landing...

14 CFR 29.505 - Ski landing conditions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Ski landing conditions. 29.505 Section 29.505 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Strength Requirements Ground Loads § 29.505 Ski landing...

SKI knockdown inhibits human melanoma tumor growth in vivo.

PubMed

Chen, Dahu; Lin, Qiushi; Box, Neil; Roop, Dennis; Ishii, Shunsuke; Matsuzaki, Koichi; Fan, Tao; Hornyak, Thomas J; Reed, Jon A; Stavnezer, Ed; Timchenko, Nikolai A; Medrano, Estela E

2009-12-01

The SKI protein represses the TGF-beta tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant melanoma tumors in a disease-progression manner and its overexpression promotes proliferation and migration of melanoma cells in vitro. The mechanisms by which SKI antagonizes TGF-beta signaling in vivo have not been fully elucidated. Here we show that human melanoma cells in which endogenous SKI expression was knocked down by RNAi produced minimal orthotopic tumor xenograft nodules that displayed low mitotic rate and prominent apoptosis. These minute tumors exhibited critical signatures of active TGF-beta signaling including high levels of nuclear Smad3 and p21(Waf-1), which are not found in the parental melanomas. To understand how SKI promotes tumor growth we used gain- and loss-of-function approaches and found that simultaneously to blocking the TGF-beta-growth inhibitory pathway, SKI promotes the switch of Smad3 from tumor suppression to oncogenesis by favoring phosphorylations of the Smad3 linker region in melanoma cells but not in normal human melanocytes. In this context, SKI is required for preventing TGF-beta-mediated downregulation of the oncogenic protein c-MYC, and for inducing the plasminogen activator inhibitor-1, a mediator of tumor growth and angiogenesis. Together, the results indicate that SKI exploits multiple regulatory levels of the TGF-beta pathway and its deficiency restores TGF-beta tumor suppressor and apoptotic activities in spite of the likely presence of oncogenic mutations in melanoma tumors.

The cultural and ecological impacts of aboriginal tourism: a case study on Taiwan's Tao tribe.

PubMed

Liu, Tzu-Ming; Lu, Dau-Jye

2014-01-01

We show that tourism activities severely impact the ecology of Orchid Island, its natural resources, and the culture of the Tao tribe. For example, highway widening, in response to the increased traffic volumes caused by tourism, required many Pandanus trees to be cut and removed, which has placed the coconut crabs in danger of extinction. To promote eco-tourism, observation trips to observe Elegant Scops owls and Birdwing butterflies have taken place, which has affected the breeding of these two protected species. The Elegant Scops owls- and Birdwing butterflies-related tourism activities also break the "evil spirits" taboo of the Tao people and have caused the disappearance of the specifications for using traditional natural resources, causing natural ecosystems to face the threat of excessive use. In addition to promoting and advocating aboriginal tourism of the Tao people on Orchid Island, the Taiwanese government should help the Tao people to develop a management model that combines traditional regulations and tourism activities.

Tank Investigation of the EDO Model 142 Hydro-Ski Research Airplane

NASA Technical Reports Server (NTRS)

Ramsen, John A.; Wadlin, Kenneth L.; Gray, George R.

1951-01-01

A tank investigation has been conducted of a 1/10-size powered-dynamic model of the Edo model 142 hydra-ski research airplane. The results of tests of two configurations are presented: One included a large ski and a ski well; the other, a small ski without a well. Water take-offs would be possible with the available thrust for either configuration: however, the configuration with the large ski emerged sooner and had less resistance from ski emergence until take-off. Longitudinal stability and landing behavior in smooth water were satisfactory for both configurations. Some alteration to the design of the tail would be desirable in order to reduce the spray loads.

Ski can negatively regulates macrophage differentiation through its interaction with PU.1

PubMed Central

Ueki, N; Zhang, L; Haymann, MJ

2010-01-01

In the hematopoietic cell system, the oncoprotein Ski dramatically affects growth and differentiation programs, in some cases leading to malignant leukemia. However, little is known about the interaction partners or signaling pathways involved in the Ski-mediated block of differentiation in hematopoietic cells. Here we show that Ski interacts with PU.1, a lineage-specific transcription factor essential for terminal myeloid differentiation, and thereby represses PU.1-dependent transcriptional activation. Consistent with this, Ski inhibits the biological function of PU.1 to promote myeloid cells to differentiate into macrophage colony-stimulating factor receptor (M-CSFR)-positive macrophages. Using a Ski mutant deficient in PU.1 binding, we demonstrate that Ski–PU.1 interaction is critical for Ski's ability to repress PU.1-dependent transcription and block macrophage differentiation. Furthermore, we provide evidence that Ski-mediated repression of PU.1 is due to Ski's ability to recruit histone deacetylase 3 to PU.1 bound to DNA. Since inactivation of PU.1 is closely related to the development of myeloid leukemia and Ski strongly inhibits PU.1 function, we propose that aberrant Ski expression in certain types of myeloid cell lineages might contribute to leukemogenesis. PMID:17621263

Flight style optimization in ski jumping on normal, large, and ski flying hills.

PubMed

Jung, Alexander; Staat, Manfred; Müller, Wolfram

2014-02-07

In V-style ski jumping, aerodynamic forces are predominant performance factors and athletes have to solve difficult optimization problems in parts of a second in order to obtain their jump length maximum and to keep the flight stable. Here, a comprehensive set of wind tunnel data was used for optimization studies based on Pontryagin's minimum principle with both the angle of attack α and the body-ski angle β as controls. Various combinations of the constraints αmax and βmin(t) were analyzed in order to compare different optimization strategies. For the computer simulation studies, the Olympic hill profiles in Esto-Sadok, Russia (HS 106m, HS 140m), and in Harrachov, Czech Republic, host of the Ski Flying World Championships 2014 (HS 205m) were used. It is of high importance for ski jumping practice that various aerodynamic strategies, i.e. combinations of α- and β-time courses, can lead to similar jump lengths which enables athletes to win competitions using individual aerodynamic strategies. Optimization results also show that aerodynamic behavior has to be different at different hill sizes (HS). Optimized time courses of α and β using reduced drag and lift areas in order to mimic recent equipment regulations differed only in a negligible way. This indicates that optimization results presented here are not very sensitive to minor changes of the aerodynamic equipment features when similar jump length are obtained by using adequately higher in-run velocities. However, wind tunnel measurements with athletes including take-off and transition to stabilized flight, flight, and landing behavior would enable a more detailed understanding of individual flight style optimization. © 2013 Published by Elsevier Ltd.

Fundamental considerations in ski binding analysis.

PubMed

Mote, C D; Hull, M L

1976-01-01

1. The static adjustment of a ski binding by hand or by available machines is only an adjustment and is neither a static nor a dynamic evaluation of the binding design. Bindings of different design with identical static adjustments will perform differently in environments in which the forces are static or dynamic. 2. The concept of binding release force is a useful measure of binding adjustment, but it is inappropriate as a criterion for binding evaluation. First, it does not direct attention toward the injury causing mechanism, strain, or displacement in the leg. Second, it is only part of the evaluation in dynamic problems. 3. The binding release decision in present bindings is displacement controlled. The relative displacement of the boot and ski is the system variable. For any specified relative displacement the binding force can be any of an infinite number of possibilities determined by the loading path. 4. The response of the leg-ski system to external impulses applied to the ski is independent of the boot-ski relative motion as long as the boot recenters quickly in the binding. Response is dependent upon the external impulse plus system inertia, damping and stiffness. 5. When tested under half sinusoidal forces applied to a test ski, all bindings will demonstrate static and impulse loading regions. In the static region the force drives the binding to a relative release displacement. In the impulse region the initial velocity of the ski drives the binding to a release displacement. 6. The transition between the static and impulse loading regions is determined by the binding's capacity to store and dissipate energy along the principal loading path. Increased energy capacity necessitates larger external impulses to produce release. 7. In all bindings examined to date, the transmitted leg displacement or strain at release under static loading exceeds leg strain under dynamic or impact loading. Because static loading is responsible for many injuries, a skier

[Ski boots versus the knee joint. 2: What produces the forward leaning position of the ski boot?].

PubMed

Schaff, P; Hauser, W

1990-03-01

In contrast to the drop in the incidence of fracture of the lower leg that has been observed in recent years, the incidence of knee injuries has not decreased in skiing. There has even been a relative increase of severe knee lesions and isolated ACL ruptures, prompting us to conduct a comprehensive study of the causes of this phenomena. The goal of part 2 of the study was to comprehensively examine the forward movement in skiboots in the lab and on the slope. Studying nine beginners and eight experts, we found a 20% (sign. 0.05) lower forward-lean capability for the beginner group in the same boot. A randomized study with crossover design conducted on the slope, where we equipped 16 skiers with either soft or stiff boots for the duration of five ski days, revealed the learning behaviour and forward position on the slope depending on the boot. The pupils became definitely less adept at learning if they were required to wear stiff skiboots and showed a sign, lower forward flex angle. A skiiing style in backward lean position was adopted and supported by the fixed backward spoiler. Therefore another study was necessary and will follow (part 3) to examine the effect of a stiff backward spoiler and skiing in a backward lean position. In consideration of the facts known up to now, it is concluded that to improve safety in skiing recommendations must be given as to which boot to choose, according to the skiing level. In addition, the setting of safety bindings must consider the type of skiboot used.

The Making of a National Hero: Tao Xingzhi's Legacies in the People's Republic of China

ERIC Educational Resources Information Center

Yao, Yusheng

2002-01-01

Tao Xingzhi (1891-1946) was an outstanding modern educator, whose theory and practice of life education represented a radical discourse in the Chinese debate on modern education and national reconstruction. Although he is most often known as a Deweyan reformer in the mainstream of American studies, in his theoretical maturity Tao can more…

Land degradation at the Stara Planina ski resort.

PubMed

Ristić, Ratko; Kašanin-Grubin, Milica; Radić, Boris; Nikić, Zoran; Vasiljević, Nevena

2012-03-01

The environmental impacts of ski resorts in the Balkan region are great and can lead to landscape degradation and loss of land functionality. In this study, we present an example of the negative effects of human activities at the Stara Planina ski resort in southeastern Serbia. The objective of this study is detailed analysis of the characteristics of environmental impacts at the Stara Planina. The management of the ski area and ski slope development caused severe degradation of topsoil and native vegetation. The morphological characteristics of the area, lithological properties of the exposed material and climate conditions resulted in various geomorphic impacts, including rills, deep gullies, solifluctions and debris from rock weathering. Significant changes in land usage altered hydrological conditions, resulting in more frequent torrential floods in the downstream sections of the Zubska River and increased the sediment yield. Environmental impacts were analyzed in the immediate and wider zones of the ski resort in accordance with the specific topography and visual exposure. The restoration and erosion control measures have stopped degradation processes and helped to rehabilitate the appearance and functions of the landscape. The results show the importance of considering lithological (the type and characteristics of minerals present) and hydrological (precipitation, water storage capacity of soil, runoff) factors under the conditions of significant changes in land usage. The results of this investigation can contribute to the improvement of planning processes and the implementation of development projects in ski areas.

Snowmaking in ski resorts: spatial decision support for management of snowpack

NASA Astrophysics Data System (ADS)

Loubier, Jean-Christophe; Kanevski, Mikhail; Doctor, Marut; Schumacher, Michael; Timonin, Vadim

2010-05-01

Since the early 2000s, the question of snowmaking that ensures activity in ski areas is controversial, because solutions to face climate change and sustainable development seem to be opposed to the economical needs of winter tourism. Actually, according to the Advisory Body on Climate Change (OCCC), we can expect an average rise of the limit of 0 degrees to 360 m in 2050. The application of the rule of 100 days (30 cm of snow for 100 days) shows that 1 ° increase in temperature reduced by 20% the number of viable skiing areas. Snowmaking seems thus to be a solution for continuing an optimal economical usage of the ski resorts. The usage of machine-made snow raises environmental issues which can no longer be denied. [Badre et al.2009] However, these issues should not be disconnected from local economic specificities of the high mountain valleys, where the ski economy is critical. This paper presents a study at the economic-environmental interface. The aim is to develop a tool for managing the production of artificial snow, with the goal to: • Reduce production costs and improve profit margins of companies operating ski areas; • Reduce environmental impacts by an optimized snow production "just in time". In this way, water and energy needs will be reduced. The problem of managing the snow is a highly complex problem: it cannot be solved analytically. Indeed, changes in height of snow are subject to intakes of snow (natural or manufactured) associated with changing weather conditions and the impact of skiers. Therefore, the work presented in this paper has chosen a probabilistic approach in a simulation using neural networks to predict and to manage snow height. We do this in two points: • We measure snowpack heights with radars mounted on grooming machines; • We produce a snow cover prediction in relation with weather prediction using a neuron network. This neural approach thus deals with the spatial prediction of snow cover [Kanevski et al., 2009] The

A Coupled Snow Operations-Skier Demand Model for the Ontario (Canada) Ski Region

NASA Astrophysics Data System (ADS)

Pons, Marc; Scott, Daniel; Steiger, Robert; Rutty, Michelle; Johnson, Peter; Vilella, Marc

2016-04-01

The multi-billion dollar global ski industry is one of the tourism subsectors most directly impacted by climate variability and change. In the decades ahead, the scholarly literature consistently projects decreased reliability of natural snow cover, shortened and more variable ski seasons, as well as increased reliance on snowmaking with associated increases in operational costs. In order to develop the coupled snow, ski operations and demand model for the Ontario ski region (which represents approximately 18% of Canada's ski market), the research utilized multiple methods, including: a in situ survey of over 2400 skiers, daily operations data from ski resorts over the last 10 years, climate station data (1981-2013), climate change scenario ensemble (AR5 - RCP 8.5), an updated SkiSim model (building on Scott et al. 2003; Steiger 2010), and an agent-based model (building on Pons et al. 2014). Daily snow and ski operations for all ski areas in southern Ontario were modeled with the updated SkiSim model, which utilized current differential snowmaking capacity of individual resorts, as determined from daily ski area operations data. Snowmaking capacities and decision rules were informed by interviews with ski area managers and daily operations data. Model outputs were validated with local climate station and ski operations data. The coupled SkiSim-ABM model was run with historical weather data for seasons representative of an average winter for the 1981-2010 period, as well as an anomalously cold winter (2012-13) and the record warm winter in the region (2011-12). The impact on total skier visits and revenues, and the geographic and temporal distribution of skier visits were compared. The implications of further climate adaptation (i.e., improving the snowmaking capacity of all ski areas to the level of leading resorts in the region) were also explored. This research advances system modelling, especially improving the integration of snow and ski operations models with

Lift mechanics of downhill skiing and snowboarding.

PubMed

Wu, Qianhong; Igci, Yesim; Andreopoulos, Yiannis; Weinbaum, Sheldon

2006-06-01

This study is conducted to develop a simplified mathematical model to describe the lift mechanics of downhill skiing and snowboarding, where the lift contributions due to both the transiently trapped air and the compressed solid phase (snow crystals) are determined. To our knowledge, this is the first time that anyone has attempted to realistically estimate the relative contribution of the transiently trapped air to the total lift in skiing and snowboarding. The model uses Shimizu's empirical relation to predict the local variation in Darcy permeability due to the compression of the solid phase. The forces and moments on the skier or snowboarder are used to predict the angle of attack of the planing surface, the penetration depth at the leading edge, and the shift in the center of pressure for two typical snow types, fresh and wind-packed snow. We present numerical solutions for snowboarding and asymptotic analytic solutions for skiing for the case where there are no edging or turning maneuvers. The force and moment balance are then used to develop a theory for control and stability in response to changes in the center of mass as the individual shifts his/her weight. Our model predicts that for fine-grained, windpacked snow that when the velocity (U) of the snowboarder or skier is 20 m.s, approximately 50% of the total lift force is generated by the trapped air for snowboarding and 40% for skiing. For highly permeable fresh powder snow, the lift contribution from the pore air pressure drops substantially. This paper develops a new theoretical framework for analyzing the lift mechanics and stability of skis and snowboards that could have important applications in future ski and snowboard design.

Feasibility study of Fe3O4/TaO x nanoparticles as a radiosensitizer for proton therapy

NASA Astrophysics Data System (ADS)

Ahn, Sang Hee; Lee, Nohyun; Choi, Changhoon; Shin, Sung Won; Han, Youngyih; Park, Hee Chul

2018-06-01

We investigated the feasibility of using multifunctional Fe3O4/TaO x (core/shell) nanoparticles, developed for use in contrast agents for computed tomography (CT) and magnetic resonance imaging (MRI), as dose-enhancing radiosensitizers. First, to verify the detectability of Fe3O4/TaO x nanoparticles in imaging, in vivo tests were conducted. Approximately 600 mg kg‑1 of 19 nm-diameter Fe3O4/TaO x nanoparticles dispersed in phosphate-buffered saline was injected into the tail vein of six Balb/c mice used as tumour (4T1 mammary carcinoma cell) models. Three mice underwent MRI (BioSpec 70/20 USR, Bruker, Billerica, MA, USA) and micro-CT (Inveon, Siemens Preclinical, Knoxville, TN, USA) before and after the injection. The difference between the pre- and post-injection images was quantified by finding the correlation coefficient. The aorta, blood vessel, and liver were clearly seen in the MRI and micro-CT images 60 min after intravenous injection of Fe3O4/TaO x nanoparticles, but the tumour region was not visible in the CT images until after 24 h. There were large differences between the pre- and post-injection images. Second, the therapeutic enhancement dose of nanomaterials was computed via Monte Carlo simulation. Monoenergetic 70- and 150 MeV proton beams irradiated x-ray contrast agent (iodine, BaSO4), MRI contrast agent (gadolinium, Fe3O4), Au, Fe3O4/TaO x (core/shell) nanoparticles and water located at the centre of a 4  ×  4  ×  4 µm3 water phantom, upon which the dose enhancement ratio (DER) (dose with/without nanoparticles) was computed. When 70 MeV protons irradiated the Au, gadolinium, Fe3O4/TaO x , Fe3O4, iodine, and BaSO4 nanoparticles, the DERs at 1 nm were 15.76, 7.68, 7.82, 6.17, 4.85, and 5.51, respectively. Fe3O4/TaO x nanoparticles have the potential to be used as a multifunctional agent that enhances tumour detection and increases the dose. Dose enhancement with Fe3O4/TaO x was half that with Au. However, Fe3O4/TaO x is

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression

PubMed Central

Rashidian, Juliet; Le Scolan, Erwan; Ji, Xiaodan; Zhu, Qingwei; Mulvihill, Melinda M.; Nomura, Daniel; Luo, Kunxin

2015-01-01

Ski, the transforming protein of the avian Sloan-Kettering retrovirus, inhibits transforming growth factor–β (TGF-β)/Smad signaling and displays both pro-oncogenic and anti-oncogenic activities in human cancer. Inhibition of TGF-β signaling is likely responsible for the pro-oncogenic activity of Ski. We investigated the mechanism(s) underlying the tumor suppressor activity of Ski and found that Ski suppressed the activity of the Hippo signaling effectors TAZ and YAP to inhibit breast cancer progression. TAZ and YAP are transcriptional coactivators that can contribute to cancer by promoting proliferation, tumorigenesis, and cancer stem cell expansion. Hippo signaling activates the the Lats family of kinases, which phosphorylate TAZ and YAP, resulting in cytoplasmic retention and degradation and inhibition of their transcriptional activity. We showed that Ski interacted with multiple components of the Hippo pathway to facilitate activation of Lats2, resulting in increased phosphorylation and subsequent degradation of TAZ. Ski also promoted the degradation of a constitutively active TAZ mutant that is not phosphorylated by Lats, suggesting the existence of a Lats2-independent degradation pathway. Finally, we showed that Ski repressed the transcriptional activity of TAZ by binding to the TAZ partner TEAD and recruiting the transcriptional co-repressor NCoR1 to the TEAD-TAZ complex. Ski effectively reversed transformation and epithelial-to-mesenchyme transition in cultured breast cancer cells and metastasis in TAZ-expressing xenografted tumors. Thus, Ski inhibited the function of TAZ through multiple mechanisms in human cancer cells. PMID:25670202

Ski and SnoN, potent negative regulators of TGF-β signaling

PubMed Central

Deheuninck, Julien; Luo, Kunxin

2011-01-01

Ski and the closely related SnoN were discovered as oncogenes by their ability to transform chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and SnoN have also been reported in many human cancer cells and tissues, consistent with their pro-oncogenic activity, emerging evidence also suggests a potential anti-oncogenic activity for both. In addition, Ski and SnoN have been implicated in regulation of cell differentiation, especially in the muscle and neuronal lineages. Multiple cellular partners of Ski and SnoN have been identified in an effort to understand the molecular mechanisms underlying the complex roles of Ski and SnoN. In this review, we summarize recent findings on the biological functions of Ski and SnoN, their mechanisms of action and how their levels of expression are regulated. PMID:19114989

Skiing in the Great Lakes States: the industry and the skier.

Treesearch

William A. Leuschner

1970-01-01

Describes the skiers and ski areas in the Midwest. Analyzes market structure for the industry, the factors associated with financial success, the impact of spending on local economies, and the potential of ski area investment. Includes ski area financial statements.

77 FR 31036 - Notice of Availability of the Record of Decision for the Taos Resource Management Plan...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... Mexico. FOR FURTHER INFORMATION CONTACT: Brad Higdon, Planning and Environmental Coordinator, Taos Field..., largely through the public participation provided under NEPA. The Draft RMP/ Environmental Impact...] Notice of Availability of the Record of Decision for the Taos Resource Management Plan/Environmental...

A sit-ski design aimed at controlling centre of mass and inertia.

PubMed

Langelier, Eve; Martel, Stéphane; Millot, Anne; Lessard, Jean-Luc; Smeesters, Cécile; Rancourt, Denis

2013-01-01

This article introduces a sit-ski developed for the Canadian Alpine Ski Team in view of the Vancouver 2010 Paralympic games. The design is predominantly based on controlling the mass distribution of the sit-ski, a critical factor in skiing performance and control. Both the antero-posterior location of the centre of mass and the sit-ski moment of inertia were addressed in our design. Our design provides means to adjust the antero-posterior centre of mass location of a sit-ski to compensate for masses that would tend to move the antero-posterior centre of mass location away from the midline of the binding area along the ski axis. The adjustment range provided is as large as 140 mm, thereby providing sufficient adaptability for most situations. The suspension mechanism selected is a four-bar linkage optimised to limit antero-posterior seat movement, due to suspension compression, to 7 mm maximum. This is about 5% of the maximum antero-posterior centre of mass control capacity (151 mm) of a human participant. Foot rest inclination was included in the design to modify the sit-ski inertia by as much as 11%. Together, these mass adjustment features were shown to drastically help athletes' skiing performance.

Shoulder injuries from alpine skiing and snowboarding. Aetiology, treatment and prevention.

PubMed

Kocher, M S; Dupré, M M; Feagin, J A

1998-03-01

There has been a decrease in the overall injury rate and the rate of lower extremity injuries for alpine skiing, with a resultant increase in the ratio of upper extremity to lower extremity injuries. Upper extremity injuries account for 20 to 35% of all injuries during alpine skiing and nearly 50% of all injuries during snowboarding. The most common upper extremity injuries during skiing are sprain of the thumb metacarpal-phalangeal joint ulnar collateral ligament, and the most common in snowboarding is wrist fracture. Shoulder injuries from skiing and snowboarding have been less well characterised. With the increased ratio of upper to lower extremity injuries during alpine skiing and the boom in popularity of snowboarding, shoulder injuries will be seen with increasing frequency by those who care for alpine sport injuries. Shoulder injuries account for 4 to 11% of all alpine skiing injuries and 22 to 41% of upper extremity injuries. The rate of shoulder injuries during alpine skiing is 0.2 to 0.5 injuries per thousand skier-days. During snowboarding, shoulder injuries account for 8 to 16% of all injuries and 20 to 34% of upper extremity injuries. Falls are the most common mechanism of shoulder injury, in addition to pole planting during skiing and aerial manoeuvres during snowboarding. Common shoulder injuries during skiing and snowboarding are glenohumeral instability, rotator cuff strains, acromioclavicular separations and clavicle fractures. Less common shoulder injuries include greater tuberosity fractures, trapezius strains, proximal humerus fractures, biceps strains, glenoid fractures, scapula fractures, humeral head fractures, sterno-clavicular separations, acromion fractures and biceps tendon dislocation. Prevention of shoulder injuries during skiing and snowboarding may be possible through interventions in education and technique, conditioning and equipment and environment.

Additional Smooth and Rough Water Trials of SKI-CAT.

DTIC Science & Technology

1981-08-01

REPORT & PERIOD COVERED ADDITIONAL SMOOTH AND ROUGH WATER TRIALS OF FINAL SKI- CAT S. PERFORMING ORO. REPORT NUMSER 7. AUTHOR() I. CONTRACT OR GRANT NUMUr...Identif by bloc membe) ’ " -Further tests of SKI- CAT were made in smooth and rough water. Smooth water results confirmed the performance results of...reductions in the accelerations and motions of SKI- CAT over against the head seasreut DD , +A ,3 1473 EDITION OF I NOVS IS OBSOLETE UNCIbSJFIED SIME 0102-014

Biomechanical factors influencing the performance of elite Alpine ski racers.

PubMed

Hébert-Losier, Kim; Supej, Matej; Holmberg, Hans-Christer

2014-04-01

Alpine ski racing is a popular international winter sport that is complex and challenging from physical, technical, and tactical perspectives. Despite the vast amount of scientific literature focusing on this sport, including topical reviews on physiology, ski-snow friction, and injuries, no review has yet addressed the biomechanics of elite alpine ski racers and which factors influence performance. In World Cup events, winning margins are often mere fractions of a second and biomechanics may well be a determining factor in podium place finishes. The aim of this paper was to systematically review the scientific literature to identify the biomechanical factors that influence the performance of elite alpine ski racers, with an emphasis on slalom, giant slalom, super-G, and downhill events. Four electronic databases were searched using relevant medical subject headings and key words, with an additional manual search of reference lists, relevant journals, and key authors in the field. Articles were included if they addressed human biomechanics, elite alpine skiing, and performance. Only original research articles published in peer-reviewed journals and in the English language were reviewed. Articles that focused on skiing disciplines other than the four of primary interest were excluded (e.g., mogul, ski-cross and freestyle skiing). The articles subsequently included for review were quality assessed using a modified version of a validated quality assessment checklist. Data on the study population, design, location, and findings relating biomechanics to performance in alpine ski racers were extracted from each article using a standard data extraction form. A total of 12 articles met the inclusion criteria, were reviewed, and scored an average of 69 ± 13% (range 40-89%) upon quality assessment. Five of the studies focused on giant slalom, four on slalom, and three on downhill disciplines, although these latter three articles were also relevant to super-G events

Separation of variables in Maxwell equations in Plebański-Demiański spacetime

NASA Astrophysics Data System (ADS)

Frolov, Valeri P.; Krtouš, Pavel; KubizÅák, David

2018-05-01

A new method for separating variables in the Maxwell equations in four- and higher-dimensional Kerr-(A)dS spacetimes proposed recently by Lunin is generalized to any off-shell metric that admits a principal Killing-Yano tensor. The key observation is that Lunin's ansatz for the vector potential can be formulated in a covariant form—in terms of the principal tensor. In particular, focusing on the four-dimensional case we demonstrate separability of Maxwell's equations in the Kerr-NUT-(A)dS and the Plebański-Demiański family of spacetimes. The new method of separation of variables is quite different from the standard approach based on the Newman-Penrose formalism.

The Tao survivorship of schistosomes: implications for schistosomiasis control.

PubMed

Cai, Pengfei; Gobert, Geoffrey N; You, Hong; McManus, Donald P

2016-06-01

Schistosomiasis, caused by blood flukes of the genus Schistosoma, is a major public health problem which contributes substantially to the economic and financial burdens of many nations in the developing world. An array of survival strategies, such as the unique structure of the tegument which acts as a major host-parasite interface, immune modulation mechanisms, gene regulation, and apoptosis and self-renewal have been adopted by schistosome parasites over the course of long-term evolution with their mammalian definitive hosts. Recent generation of complete schistosome genomes together with numerous biological, immunological, high-throughput "-omics" and gene function studies have revealed the Tao or strategies that schistosomes employ not only to promote long-term survival, but also to ensure effective life cycle transmission. New scenarios for the future control of this important neglected tropical disease will present themselves as our understanding of these Tao increases. Copyright © 2016 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

Status of the Transneptunian Automated Occultation Survey (TAOS II)

NASA Astrophysics Data System (ADS)

Lehner, Matthew; Wang, Shiang-Yu; Reyes-Ruiz, Mauricio; Alcock, Charles; Castro Chacón, Joel; Chen, Wen-Ping; Chu, You-Hua; Cook, Kem H.; Figueroa, Liliana; Geary, John C.; Hernandez, Benjamin; Huang, Chung-Kai; Norton, Timothy; Szentgyorgyi, Andrew; Yen, Wei-Ling; Zhang, Zhi-Wei

2017-10-01

The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small (~1 km diameter) objects in the Kuiper Belt and beyond. Such events are very rare (<0.001 events per star per year) and short in duration (~200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astronómico Nacional at San Pedro Mártir in Baja California, México. With a 2.3 square degree field of view and a high speed camera comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz. Construction of the site began in the fall of 2013 and was completed this summer. Telescope installation began in August 2017. This poster will provide an update on the status of the survey development and the schedule leading to the beginning of survey operations.

Effect of ski geometry and standing height on kinetic energy: equipment designed to reduce risk of severe traumatic injuries in alpine downhill ski racing.

PubMed

Gilgien, Matthias; Spörri, Jörg; Kröll, Josef; Müller, Erich

2016-01-01

Injuries in downhill (DH) are often related to high speed and, therefore, to high energy and forces which are involved in injury situations. Yet to date, no study has investigated the effect of ski geometry and standing height on kinetic energy (EKIN) in DH. This knowledge would be essential to define appropriate equipment rules that have the potential to protect the athletes' health. During a field experiment on an official World Cup DH course, 2 recently retired world class skiers skied on 5 different pairs of skis varying in width, length and standing height. Course characteristics, terrain and the skiers' centre of mass position were captured by a differential Global Navigational Satellite System-based methodology. EKIN, speed, ski-snow friction force (FF), ground reaction force (FGRF) and ski-snow friction coefficient (CoeffF) were calculated and analysed in dependency of the used skis. In the steep terrain, longer skis with reduced width and standing height significantly decreased average EKIN by ∼ 3%. Locally, even larger reductions of EKIN were observed (up to 7%). These local decreases in EKIN were mainly explainable by higher FF. Moreover, CoeffF differences seem of greater importance for explaining local FF differences than the differences in FGRF. Knowing that increased speed and EKIN likely lead to increased forces in fall/crash situations, the observed equipment-induced reduction in EKIN can be considered a reasonable measure to improve athlete safety, even though the achieved preventative gains are rather small and limited to steep terrain. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Suppression of p53 Activity through the Cooperative Action of Ski and Histone Deacetylase SIRT1*

PubMed Central

Inoue, Yasumichi; Iemura, Shun-ichiro; Natsume, Tohru; Miyazawa, Keiji; Imamura, Takeshi

2011-01-01

Ski was originally identified as an oncogene based on the fact that Ski overexpression transformed chicken and quail embryo fibroblasts. Consistent with these proposed oncogenic roles, Ski is overexpressed in various human tumors. However, whether and how Ski functions in mammalian tumorigenesis has not been fully investigated. Here, we show that Ski interacts with p53 and attenuates the biological functions of p53. Ski overexpression attenuated p53-dependent transactivation, whereas Ski knockdown enhanced the transcriptional activity of p53. Interestingly, Ski bound to the histone deacetylase SIRT1 and stabilized p53-SIRT1 interaction to promote p53 deacetylation, which subsequently decreased the DNA binding activity of p53. Consistent with the ability of Ski to inactivate p53, overexpressing Ski desensitized cells to genotoxic drugs and Nutlin-3, a small-molecule antagonist of Mdm2 that stabilizes p53 and activates the p53 pathway, whereas knocking down Ski increased the cellular sensitivity to these agents. These results indicate that Ski negatively regulates p53 and suggest that the p53-Ski-SIRT1 axis is an attractive target for cancer therapy. PMID:21149449

Changes in the Balance Performance of Polish Recreational Skiers after Seven Days of Alpine Skiing

PubMed Central

Wojtyczek, Beata; Pasławska, Małgorzata; Raschner, Christian

2014-01-01

Alpine skiing is one of the most popular leisure time winter sporting activities. Skiing imposes high requirements concerning physical fitness, particularly regarding balance abilities. The main objective of this study was to evaluate the changes in balance performance of recreational skiers after a seven-day ski camp. A total of 78 students - 24 women and 54 men - participated in the study. The ski course was held in accordance with the official program of the Polish Ski Federation. The study sample was comprised of 43 beginners and 35 intermediate skiers. All students were tested with the MFT S3-Check, the day before and the day after the ski camp. The test system consisted of an unstable uniaxial platform, with an integrated sensor and corresponding software. Changes in balance performance (sensory and stability index) were evaluated using paired t-tests. Additionally, changes in sensory and stability categories, which were based on the norm data, were analyzed. Female and male participants showed significantly better sensory and stability indices after skiing. Considerable changes from weak or very weak to average or good balance categories could be seen after skiing for both sexes. Regarding skiing experience, both beginners and intermediate skiers improved their sensory and stability indices significantly after skiing. Hence, recreational alpine skiing resulted in better balance performance regardless of sex or skiing experience. Skiing as an outdoor activity offers the opportunity to improve balance performance with a positive impact on everyday life activities. PMID:25713663

Changes in the balance performance of polish recreational skiers after seven days of alpine skiing.

PubMed

Wojtyczek, Beata; Pasławska, Małgorzata; Raschner, Christian

2014-12-09

Alpine skiing is one of the most popular leisure time winter sporting activities. Skiing imposes high requirements concerning physical fitness, particularly regarding balance abilities. The main objective of this study was to evaluate the changes in balance performance of recreational skiers after a seven-day ski camp. A total of 78 students - 24 women and 54 men - participated in the study. The ski course was held in accordance with the official program of the Polish Ski Federation. The study sample was comprised of 43 beginners and 35 intermediate skiers. All students were tested with the MFT S3-Check, the day before and the day after the ski camp. The test system consisted of an unstable uniaxial platform, with an integrated sensor and corresponding software. Changes in balance performance (sensory and stability index) were evaluated using paired t-tests. Additionally, changes in sensory and stability categories, which were based on the norm data, were analyzed. Female and male participants showed significantly better sensory and stability indices after skiing. Considerable changes from weak or very weak to average or good balance categories could be seen after skiing for both sexes. Regarding skiing experience, both beginners and intermediate skiers improved their sensory and stability indices significantly after skiing. Hence, recreational alpine skiing resulted in better balance performance regardless of sex or skiing experience. Skiing as an outdoor activity offers the opportunity to improve balance performance with a positive impact on everyday life activities.

Questa Baseline and Pre-Mining Ground-Water Quality Investigation. 17. Geomorphology of the Red River Valley, Taos County, New Mexico, and Influence on Ground-Water Flow in the Shallow Alluvial Aquifer

USGS Publications Warehouse

Vincent, Kirk R.

2008-01-01

In April 2001, the U.S. Geological Survey (USGS) and the New Mexico Environment Department (NMED) began a cooperative study to infer the pre-mining ground-water chemistry at the Molycorp molybdenum mine site in the Red River Valley of north-central New Mexico. This report is one in a series of reports that can be used to determine pre-mining ground-water conditions at the mine site. Molycorp?s Questa molybdenum mine in the Red River Valley, northern New Mexico, is located near the margin of the Questa caldera in a highly mineralized region. The bedrock of the Taos Range surrounding the Red River is composed of Proterozoic rocks of various types, which are intruded and overlain by Oligocene volcanic rocks associated with the Questa caldera. Locally, these rocks were altered by hydrothermal activity. The alteration zones that contain sulfide minerals are particularly important because they constitute the commercial ore bodies of the region and, where exposed to weathering, form sites of rapid erosion referred to as alteration scars. Over the past thousand years, if not over the entire Holocene, erosion rates were spatially variable. Forested hillslopes eroded at about 0.04 millimeter per year, whereas alteration scars eroded at about 2.7 millimeters per year. The erosion rate of the alteration scars is unusually rapid for naturally occurring sites that have not been disturbed by humans. Watersheds containing large alteration scars delivered more sediment to the Red River Valley than the Red River could remove. Consequently, large debris fans, as much as 80 meters thick, developed within the valley. The geomorphology of the Red River Valley has had several large influences on the hydrology of the shallow alluvial aquifer, and those influences were in effect before the onset of mining within the watershed. Several reaches where alluvial ground water emerges to become Red River streamflow were observed by a tracer dilution study conducted in 2001. The aquifer narrows

Sustaining a Moored Ocean Observing System in the Tropical Pacific: The Evolution of the TAO Array

NASA Astrophysics Data System (ADS)

Grissom, K.; Kessler, W. S.; McArthur, S.

2016-12-01

The Tropical Atmosphere Ocean (TAO) array has been a major observational component of El Niño Southern Oscillation (ENSO) research and operational climate forecasting since its conception in 1984. Developed by NOAA's Pacific Marine Environmental Laboratory (PMEL) in response to the poorly-observed 1982-1983 El Niño, the moored buoy array was completed in 1994 and transitioned from PMEL to NOAA's National Data Buoy Center (NDBC) in 2005. During this transition, the TAO Refresh project was initiated to address equipment obsolescence and the need for more real-time data. Completed in 2011, the "TAO Refresh" array has new capabilities and added value. Then in 2012, federal resource shortfalls threatened the future sustainability of this array. The resulting limited maintenance caused a decline in real-time data, yet it also served as the impetus to focus international attention on the demands of sustaining an observing system capable of monitoring the tropical ocean-atmosphere interaction. To continue collecting observations at historical levels, NOAA and partners needed an alternate strategy, and to this end conceived the international TPOS 2020 project, the Tropical Pacific Observing System for 2020. At more than 30 years, the TAO array stands as one of the longest sustained in-situ ocean observing networks in the world and provides a rare long-term record of a dominant climate signal. Here we review the evolution of the TAO array, from its development at PMEL, to its transition and modernization at NDBC, and provide a preview of its future as a key element of the Tropical Pacific Observing System.

Changes in Quadriceps Muscle Activity During Sustained Recreational Alpine Skiing

PubMed Central

Kröll, Josef; Müller, Erich; Seifert, John G.; Wakeling, James M.

2011-01-01

During a day of skiing thousands of repeated contractions take place. Previous research on prolonged recreational alpine skiing show that physiological changes occur and hence some level of fatigue is inevitable. In the present paper the effect of prolonged skiing on the recruitment and coordination of the muscle activity was investigated. Six subjects performed 24 standardized runs. Muscle activity during the first two (PREskiing) and the last two (POSTskiing) runs was measured from the vastus lateralis (VL) and rectus femoris (RF) using EMG and quantified using wavelet and principal component analysis. The frequency content of the EMG signal shifted in seven out of eight cases significantly towards lower frequencies with highest effects observed for RF on outside leg. A significant pronounced outside leg loading occurred during POSTskiing and the timing of muscle activity peaks occurred more towards turn completion. Specific EMG frequency changes were observed at certain time points throughout the time windows and not over the whole double turn. It is suggested that general muscular fatigue, where additional specific muscle fibers have to be recruited due to the reduced power output of other fibers did not occur. The EMG frequency decrease and intensity changes for RF and VL are caused by altered timing (coordination) within the turn towards a most likely more uncontrolled skiing technique. Hence, these data provide evidence to suggest recreational skiers alter their skiing technique before a potential change in muscle fiber recruitment occurs. Key points The frequency content of the EMG signal shifted in seven out of eight cases significantly towards lower frequencies with highest effects observed for RF. General muscular fatigue, where additional specific fibers have to be recruited due to the reduced power output of other fibers, did not occur. A modified skiing style towards a less functional and hence more uncontrolled skiing technique seems to be a key

The glass-like thermal conductivity in ZrO2-Dy3TaO7 ceramic for promising thermal barrier coating application

NASA Astrophysics Data System (ADS)

Wu, Peng; Hu, Ming Yu; Chong, Xiao Yu; Feng, Jing

2018-03-01

Using the solid-state reaction method, the (ZrO2)x-(Dy3TaO7)1-x (x = 0, 0.02, 0.04, 0.06, 0.08, and 0.1) ceramics are synthesized in this work. The identification of the crystal structures indicates that the (ZrO2)x-(Dy3TaO7)1-x ceramics belong to the orthorhombic system, and the space group is C2221 in spite of the value of x increasing to 0.1. The thermal conductivities of the (ZrO2)x-(Dy3TaO7)1-x ceramics range from 1.3 W/(m K) to 1.8 W/(m K), and this value is much lower than that of 7-8 YSZ (yttria-stabilized zirconia). Besides, the (ZrO2)x-(Dy3TaO7)1-x ceramics possess the glass-like thermal conductivity caused by intrinsic oxygen vacancies existing in the lattice of Dy3TaO7. Moreover, the results of thermal expansion rates demonstrate that the (ZrO2)x-(Dy3TaO7)1-x ceramics possess excellent high temperature phase stability, and the thermal expansion coefficients [(9.7-11) × 10-6 K-1] are comparable to that of 7-8 YSZ.

SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta.

PubMed

Lin, Qiushi; Chen, Dahu; Timchenko, Nikolai A; Medrano, Estela E

2010-05-01

The transcriptional co-regulator SKI is a potent inhibitor of TGFbeta-growth inhibitory signals. SKI binds to receptor-activated Smads in the nucleus, forming repressor complexes containing HDACs, mSin3, NCoR, and other protein partners. Alternatively, SKI binds to activated Smads in the cytoplasm, preventing their nuclear translocation. SKI is necessary for anchorage-independent growth of melanoma cells in vitro, and most important, for human melanoma xenograft growth in vivo. We recently identified a novel role of SKI in TGFbeta signaling. SKI promotes the switch of Smad3 from repressor of proliferation to activator of oncogenesis by facilitating phosphorylations in the linker domain. High levels of endogenous SKI are required by the tumor promoting trait of TGFbeta to induce expression of the plasminogen-activator inhibitor-1 (PAI-1), sustained expression of C-Myc and for aborting upregulation of p21(Waf-1). Here we discuss how SKI diversifies and amplifies its functions by associating with multiple protein partners and by promoting Smad3 linker phosphorylation(s) in response to TGFbeta signaling in melanoma cells.

Long-Term Athletic Development in Youth Alpine Ski Racing: The Effect of Physical Fitness, Ski Racing Technique, Anthropometrics and Biological Maturity Status on Injuries

PubMed Central

Müller, Lisa; Hildebrandt, Carolin; Müller, Erich; Fink, Christian; Raschner, Christian

2017-01-01

Alpine ski racing is known to be a sport with a high risk of injuries. Because most studies have focused mainly on top-level athletes and on traumatic injuries, limited research exists about injury risk factors among youth ski racers. The aim of this study was to determine the intrinsic risk factors (anthropometrics, biological maturity, physical fitness, racing technique) for injury among youth alpine ski racers. Study participants were 81 youth ski racers attending a ski boarding school (50 males, 31 females; 9–14 years). A prospective longitudinal cohort design was used to monitor sports-related risk factors over two seasons and traumatic (TI) and overuse injuries (OI). At the beginning of the study, anthropometric characteristics (body height, body weight, sitting height, body mass index); biological maturity [status age at peak height velocity (APHV)]; physical performance parameters related to jump coordination, maximal leg and core strength, explosive and reactive strength, balance and endurance; and ski racing technique were assessed. Z score transformations normalized the age groups. Multivariate binary logistic regression (dependent variable: injury yes/no) and multivariate linear regression analyses (dependent variable: injury severity in total days of absence from training) were calculated. T-tests and multivariate analyses of variance were used to reveal differences between injured and non-injured athletes and between injury severity groups. The level of significance was set to p < 0.05. Relatively low rates of injuries were reported for both traumatic (0.63 TI/athlete) and overuse injuries (0.21 OI/athlete). Athletes with higher body weight, body height, and sitting height; lower APHV values; better core flexion strength; smaller core flexion:extension strength ratio; shorter drop jump contact time; and higher drop jump reactive strength index were at a lower injury risk or more vulnerable for fewer days of absence from training. However

Long-Term Athletic Development in Youth Alpine Ski Racing: The Effect of Physical Fitness, Ski Racing Technique, Anthropometrics and Biological Maturity Status on Injuries.

PubMed

Müller, Lisa; Hildebrandt, Carolin; Müller, Erich; Fink, Christian; Raschner, Christian

2017-01-01

Alpine ski racing is known to be a sport with a high risk of injuries. Because most studies have focused mainly on top-level athletes and on traumatic injuries, limited research exists about injury risk factors among youth ski racers. The aim of this study was to determine the intrinsic risk factors (anthropometrics, biological maturity, physical fitness, racing technique) for injury among youth alpine ski racers. Study participants were 81 youth ski racers attending a ski boarding school (50 males, 31 females; 9-14 years). A prospective longitudinal cohort design was used to monitor sports-related risk factors over two seasons and traumatic (TI) and overuse injuries (OI). At the beginning of the study, anthropometric characteristics (body height, body weight, sitting height, body mass index); biological maturity [status age at peak height velocity (APHV)]; physical performance parameters related to jump coordination, maximal leg and core strength, explosive and reactive strength, balance and endurance; and ski racing technique were assessed. Z score transformations normalized the age groups. Multivariate binary logistic regression (dependent variable: injury yes/no) and multivariate linear regression analyses (dependent variable: injury severity in total days of absence from training) were calculated. T -tests and multivariate analyses of variance were used to reveal differences between injured and non-injured athletes and between injury severity groups. The level of significance was set to p < 0.05. Relatively low rates of injuries were reported for both traumatic (0.63 TI/athlete) and overuse injuries (0.21 OI/athlete). Athletes with higher body weight, body height, and sitting height; lower APHV values; better core flexion strength; smaller core flexion:extension strength ratio; shorter drop jump contact time; and higher drop jump reactive strength index were at a lower injury risk or more vulnerable for fewer days of absence from training. However, significant

The influence of grip on oxygen consumption and leg forces when using classical style roller skis.

PubMed

Ainegren, M; Carlsson, P; Laaksonen, M S; Tinnsten, M

2014-04-01

The purpose of this study was to investigate the influence of classical style roller skis' grip (static friction coefficients, μS) on cross-country skiers' oxygen consumption and leg forces during treadmill roller skiing, when using the diagonal stride and kick double poling techniques. The study used ratcheted wheel roller skis from the open market and a uniquely designed roller ski with an adjustable camber and grip function. The results showed significantly (P ≤ 0.05) higher oxygen consumption (∼ 14%), heart rate (∼ 7%), and lower propulsive forces from the legs during submaximal exercise and a shorter time to exhaustion (∼ 30%) in incremental maximal tests when using roller skis with a μS similar to on-snow skiing, while there was no difference between tests when using different pairs of roller skis with a similar, higher μS. Thus, we concluded that oxygen consumption (skiing economy), propulsive leg forces, and performance time are highly changed for the worse when using roller skis with a lower μS, such as for on-snow skiing with grip-waxed cross-country skis, in comparison to ratcheted wheel roller skis with several times higher μS. © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A reappraisal of success factors for Olympic cross-country skiing.

PubMed

Sandbakk, Øyvind; Holmberg, Hans-Christer

2014-01-01

Cross-country (XC) skiing has been an Olympic event since the first Winter Games in Chamonix, France, in 1924. Due to more effective training and tremendous improvements in equipment and track preparation, the speed of Olympic XC-ski races has increased more than that of any other Olympic endurance sport. Moreover, pursuit, mass-start, and sprint races have been introduced. Indeed, 10 of the 12 current Olympic competitions in XC skiing involve mass starts, in which tactics play a major role and the outcome is often decided in the final sprint. Accordingly, reappraisal of the success factors for performance in this context is required. The very high aerobic capacity (VO2max) of many of today's world-class skiers is similar that of their predecessors. At the same time, the new events provide more opportunities to profit from anaerobic capacity, upper-body power, high-speed techniques, and "tactical flexibility." The wide range of speeds and slopes involved in XC skiing requires skiers to continuously alternate between and adapt different subtechniques during a race. This technical complexity places a premium on efficiency. The relative amounts of endurance training performed at different levels of intensity have remained essentially constant during the past 4 decades. However, in preparation for the Sochi Olympics in 2014, XC skiers are performing more endurance training on roller skis on competition-specific terrain, placing greater focus on upper-body power and more systematically performing strength training and skiing at high speeds than previously.

Impact of climate change on the operation of ski slopes in South Korea

NASA Astrophysics Data System (ADS)

Kim, S.; Park, J. H.; Lee, D. K.

2017-12-01

The purpose of this study is to predict changes in the operation of ski slopes due to climate change and offer meaningful implications that the ski industry can refer to when preparing to address climate change. All 17 ski resorts in South Korea were selected as study sites. To determine the weather and managerial conditions for the operation of ski slopes, interviews with operators and a review of past weather and operational conditions were conducted. To project future changes in the season of operation for ski slopes, future weather data for the 2030s, 2060s, and 2090s from RCP scenarios were adapted to the conditions for the operation of ski slopes.The study found that the artificial snowmaking begins when the temperature reaches -2 °C, the slope is opened 9 days after artificial snowmaking starts, and the slope is closed when the temperature reaches 0 °C. By applying future weather data to these conditions, it is estimated that the ski season will decrease in the future as follows: from around 130 days at present to around 120 days based on RCP 2.0 and RCP 6.0, around 130 days based on RCP 4.5, and 90 days based on RCP 8.5 in the areas where the average temperature of the ski season is below -2 °C; from around 120 days at present to around 120 days based on RCP 2.0 and 4.5, around 100-days based on RCP 6.0, and 60 days based on RCP 8.5 in the areas where the average temperature of the ski season is below 0 °C; from around 90 days at present to around 80 days based on RCP 2.0, around 90 days based on RCP 4.5, around 50 days based on RCP 6.0, and 10 days based on RCP 8.5 in the areas where the average temperature of the ski season is above 0 °C. In addition, it is also estimated that in the 2090s, 16 of 17 ski resorts can survive based on RCP 2.6 and RCP 4.5, 13 ski resorts can survive based on RCP 6.0, and none of the resorts can survive based on RCP 8.5, according to the 100-days rule, which is the minimum required duration of the operation of ski resorts

Cross-Country Skiing Injuries and Training Methods.

PubMed

Nagle, Kyle B

2015-01-01

Cross-country skiing is a low injury-risk sport that has many health benefits and few long-term health risks. Some concern exists that cross-country skiing may be associated with a higher incidence of atrial fibrillation; however, mortality rates among skiers are lower than those among the general population. While continuing to emphasize aerobic and anaerobic training, training methods also should promote ski-specific strength training to increase maximum force and its rate of delivery and to build muscular endurance to maintain that power through a race. Multiple tests are available to monitor training progress. Which tests are most appropriate depends on the specific events targeted. In addition to laboratory-based tests, there also are many simpler, more cost-effective tests, such as short time trials, that can be used to monitor training progress and predict performance particularly at the junior skier level where access and cost may be more prohibitive.

JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity.

PubMed

Kapfhamer, David; King, Ian; Zou, Mimi E; Lim, Jana P; Heberlein, Ulrike; Wolf, Fred W

2012-01-01

Neuronal signal transduction by the JNK MAP kinase pathway is altered by a broad array of stimuli including exposure to the widely abused drug ethanol, but the behavioral relevance and the regulation of JNK signaling is unclear. Here we demonstrate that JNK signaling functions downstream of the Sterile20 kinase family gene tao/Taok3 to regulate the behavioral effects of acute ethanol exposure in both the fruit fly Drosophila and mice. In flies tao is required in neurons to promote sensitivity to the locomotor stimulant effects of acute ethanol exposure and to establish specific brain structures. Reduced expression of key JNK pathway genes substantially rescued the structural and behavioral phenotypes of tao mutants. Decreasing and increasing JNK pathway activity resulted in increased and decreased sensitivity to the locomotor stimulant properties of acute ethanol exposure, respectively. Further, JNK expression in a limited pattern of neurons that included brain regions implicated in ethanol responses was sufficient to restore normal behavior. Mice heterozygous for a disrupted allele of the homologous Taok3 gene (Taok3Gt) were resistant to the acute sedative effects of ethanol. JNK activity was constitutively increased in brains of Taok3Gt/+ mice, and acute induction of phospho-JNK in brain tissue by ethanol was occluded in Taok3Gt/+ mice. Finally, acute administration of a JNK inhibitor conferred resistance to the sedative effects of ethanol in wild-type but not Taok3Gt/+ mice. Taken together, these data support a role of a TAO/TAOK3-JNK neuronal signaling pathway in regulating sensitivity to acute ethanol exposure in flies and in mice.

Ski jump takeoff performance predictions for a mixed-flow, remote-lift STOVL aircraft

NASA Technical Reports Server (NTRS)

Birckelbaw, Lourdes G.

1992-01-01

A ski jump model was developed to predict ski jump takeoff performance for a short takeoff and vertical landing (STOVL) aircraft. The objective was to verify the model with results from a piloted simulation of a mixed flow, remote lift STOVL aircraft. The prediction model is discussed. The predicted results are compared with the piloted simulation results. The ski jump model can be utilized for basic research of other thrust vectoring STOVL aircraft performing a ski jump takeoff.

[Comparison between ski and snowboarding accidents. Current overview from the ski area Arosa (Switzerland) (1988/89 to 1994/95)].

PubMed

Fischler, L; Röthlisberger, M

1996-06-11

The ski resort of Arosa (Switzerland) is geographically isolated and has recorded it winter sports accidents since 1969. Based on this reliable data, the ski (3877 in total) and snowboard (512 in total) accidents of the last seven years were statistically analyzed. The study showed that snowboarding isn't much more dangerous than skiing the number of accidents was about the same in both groups, whereas snowboarders were less likely to be admitted to a hospital or to get injured by collision. The average age of snowboarders was 21.6 years, almost 20 years lower than that of the skiers. Both sexes were about equally represented. Most snowboarders had injuries of the upper extremity (14% fractures of the radius, 9% distortions), particularly because of falling backward after losing balance. In both groups (skiers and snowboarders) 60% of all injuries were of low grade, which did not lead to long absence from work. The results are discussed and compared with already existing publications.

Ecological Impacts of Revegetation and Management Practices of Ski Slopes in Northern Finland

NASA Astrophysics Data System (ADS)

Kangas, Katja; Tolvanen, Anne; Kälkäjä, Tarja; Siikamäki, Pirkko

2009-09-01

Outdoor recreation and nature-based tourism represent an increasingly intensive form of land use that has considerable impacts on native ecosystems. The aim of this paper is to investigate how revegetation and management of ski runs influence soil nutrients, vegetation characteristics, and the possible invasion of nonnative plant species used in revegetation into native ecosystems. A soil and vegetation survey at ski runs and nearby forests, and a factorial experiment simulating ski run construction and management (factors: soil removal, fertilization, and seed sowing) were conducted at Ruka ski resort, in northern Finland, during 2003-2008. According to the survey, management practices had caused considerable changes in the vegetation structure and increased soil nutrient concentrations, pH, and conductivity on the ski runs relative to nearby forests. Seed mixture species sown during the revegetation of ski runs had not spread to adjacent forests. The experimental study showed that the germination of seed mixture species was favored by treatments simulating the management of ski runs, but none of them could eventually establish in the study forest. As nutrient leaching causes both environmental deterioration and changes in vegetation structure, it may eventually pose a greater environmental risk than the spread of seed mixture species alone. Machine grading and fertilization, which have the most drastic effects on soils and vegetation, should, therefore, be minimized when constructing and managing ski runs.

Ecological impacts of revegetation and management practices of ski slopes in northern Finland.

PubMed

Kangas, Katja; Tolvanen, Anne; Kälkäjä, Tarja; Siikamäki, Pirkko

2009-09-01

Outdoor recreation and nature-based tourism represent an increasingly intensive form of land use that has considerable impacts on native ecosystems. The aim of this paper is to investigate how revegetation and management of ski runs influence soil nutrients, vegetation characteristics, and the possible invasion of nonnative plant species used in revegetation into native ecosystems. A soil and vegetation survey at ski runs and nearby forests, and a factorial experiment simulating ski run construction and management (factors: soil removal, fertilization, and seed sowing) were conducted at Ruka ski resort, in northern Finland, during 2003-2008. According to the survey, management practices had caused considerable changes in the vegetation structure and increased soil nutrient concentrations, pH, and conductivity on the ski runs relative to nearby forests. Seed mixture species sown during the revegetation of ski runs had not spread to adjacent forests. The experimental study showed that the germination of seed mixture species was favored by treatments simulating the management of ski runs, but none of them could eventually establish in the study forest. As nutrient leaching causes both environmental deterioration and changes in vegetation structure, it may eventually pose a greater environmental risk than the spread of seed mixture species alone. Machine grading and fertilization, which have the most drastic effects on soils and vegetation, should, therefore, be minimized when constructing and managing ski runs.

Novel Regulation of Ski Protein Stability and Endosomal Sorting by Actin Cytoskeleton Dynamics in Hepatocytes*

PubMed Central

Vázquez-Victorio, Genaro; Caligaris, Cassandre; Del Valle-Espinosa, Eugenio; Sosa-Garrocho, Marcela; González-Arenas, Nelly R.; Reyes-Cruz, Guadalupe; Briones-Orta, Marco A.; Macías-Silva, Marina

2015-01-01

TGF-β-induced antimitotic signals are highly regulated during cell proliferation under normal and pathological conditions, such as liver regeneration and cancer. Up-regulation of the transcriptional cofactors Ski and SnoN during liver regeneration may favor hepatocyte proliferation by inhibiting TGF-β signals. In this study, we found a novel mechanism that regulates Ski protein stability through TGF-β and G protein-coupled receptor (GPCR) signaling. Ski protein is distributed between the nucleus and cytoplasm of normal hepatocytes, and the molecular mechanisms controlling Ski protein stability involve the participation of actin cytoskeleton dynamics. Cytoplasmic Ski is partially associated with actin and localized in cholesterol-rich vesicles. Ski protein stability is decreased by TGF-β/Smads, GPCR/Rho signals, and actin polymerization, whereas GPCR/cAMP signals and actin depolymerization promote Ski protein stability. In conclusion, TGF-β and GPCR signals differentially regulate Ski protein stability and sorting in hepatocytes, and this cross-talk may occur during liver regeneration. PMID:25561741

A shifting rift—Geophysical insights into the evolution of Rio Grande rift margins and the Embudo transfer zone near Taos, New Mexico

USGS Publications Warehouse

Grauch, V.J.S.; Bauer, Paul W.; Drenth, Benjamin J.; Kelson, Keith I.

2017-01-01

We present a detailed example of how a subbasin develops adjacent to a transfer zone in the Rio Grande rift. The Embudo transfer zone in the Rio Grande rift is considered one of the classic examples and has been used as the inspiration for several theoretical models. Despite this attention, the history of its development into a major rift structure is poorly known along its northern extent near Taos, New Mexico. Geologic evidence for all but its young rift history is concealed under Quaternary cover. We focus on understanding the pre-Quaternary evidence that is in the subsurface by integrating diverse pieces of geologic and geophysical information. As a result, we present a substantively new understanding of the tectonic configuration and evolution of the northern extent of the Embudo fault and its adjacent subbasin.We integrate geophysical, borehole, and geologic information to interpret the subsurface configuration of the rift margins formed by the Embudo and Sangre de Cristo faults and the geometry of the subbasin within the Taos embayment. Key features interpreted include (1) an imperfect D-shaped subbasin that slopes to the east and southeast, with the deepest point ∼2 km below the valley floor located northwest of Taos at ∼36° 26′N latitude and 105° 37′W longitude; (2) a concealed Embudo fault system that extends as much as 7 km wider than is mapped at the surface, wherein fault strands disrupt or truncate flows of Pliocene Servilleta Basalt and step down into the subbasin with a minimum of 1.8 km of vertical displacement; and (3) a similar, wider than expected (5–7 km) zone of stepped, west-down normal faults associated with the Sangre de Cristo range front fault.From the geophysical interpretations and subsurface models, we infer relations between faulting and flows of Pliocene Servilleta Basalt and older, buried basaltic rocks that, combined with geologic mapping, suggest a revised rift history involving shifts in the locus of fault activity as

Applied Biomechanics Research for the United States Ski Team.

ERIC Educational Resources Information Center

Dillman, Charles J.

1982-01-01

Assisted by a team of physicians and sports scientists, the United States Ski Team has developed its own sports medicine program, the purpose of which is to assist coaches and athletes in controlling and optimizing factors which influence skiing performance. A number of biomechanical research projects which have been undertaken as part of this…

Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yi; Pirisi, Lucia; Creek, Kim E., E-mail: creekk@sccp.sc.edu

2013-09-15

We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in HKc/HPV16 and even further in HKc/DR, compared to HKc. TGF-β treatment of HKc, HKc/HPV16, and HKc/DR dramatically decreased Ski. TGF-β-induced Ski degradation was delayed in HKc/DR. Ski and phospho-Ski protein levels are cell cycle dependent with maximal Ski expression and localization to centrosomes and mitotic spindles during G2/M. ShRNA knock down of Ski in HKc/DR inhibited cellmore » proliferation. More intense nuclear and cytoplasmic Ski staining and altered Ski localization were found in cervical cancer samples compared to adjacent normal tissue in a cervical cancer tissue array. Overall, these studies demonstrate altered Ski protein levels, degradation and localization in HPV16-transformed human keratinocytes and in cervical cancer. - Highlights: • Ski oncoprotein levels increase during progression of HPV16-transformed cells. • Ski and phospho-Ski protein levels are cell cycle dependent. • Ski knock-down in HPV16-transformed keratinocytes inhibited cell proliferation. • Cervical cancer samples overexpress Ski.« less

THE TAOS PROJECT: RESULTS FROM SEVEN YEARS OF SURVEY DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Z.-W.; Lehner, M. J.; Wang, J.-H.

2013-07-01

The Taiwanese-American Occultation Survey (TAOS) aims to detect serendipitous occultations of stars by small ({approx}1 km diameter) objects in the Kuiper Belt and beyond. Such events are very rare (<10{sup -3} events per star per year) and short in duration ({approx}200 ms), so many stars must be monitored at a high readout cadence. TAOS monitors typically {approx}500 stars simultaneously at a 5 Hz readout cadence with four telescopes located at Lulin Observatory in central Taiwan. In this paper, we report the results of the search for small Kuiper Belt objects (KBOs) in seven years of data. No occultation events weremore » found, resulting in a 95% c.l. upper limit on the slope of the faint end of the KBO size distribution of q = 3.34-3.82, depending on the surface density at the break in the size distribution at a diameter of about 90 km.« less

Physiological Responses of Elderly Recreational Alpine Skiers of Different Fitness and Skiing Abilities

PubMed Central

Krautgasser, Sabine; Scheiber, Peter; von Duvillard, Serge P.; Müller, Erich

2011-01-01

We measured physiological responses of elderly recreational skiers of different fitness and skiing abilities. Six subjects (mean age: 61.2 ± 4.6 yrs; Wt: 76.8 ± 15.6 kg; Ht: 1.69 ± 0.10 m; BMI: 26.9 ± 5.0) were tested in a laboratory and during 30 and 75 min of recreational downhill skiing. Oxygen uptake (VO2), heart rate (HR), blood lactate (LA) concentration, and diastolic (DBP) and systolic (SBP) blood pressure were used to estimate energy demands while skiing. During maximal testing in a laboratory, subjects achieved a mean maximal VO2max of 28.2 ± 7.5 ml.kg-1.min-1 and a mean HRpeak of 165 ± 4 bpm (98 ± 1% of HRmax). Mean maximal workload measured on a cycle ergometer was 2.2 ± 0.7 W.kg-1 with a mean LApeak of 7.4 ± 1 mmol.l-1. During field testing, mean VO2 during skiing was 12 ± 2 ml.kg-1.min-1 (45 ± 16% of VO2max). Skiing VO2peak was 19 ± 5 ml. kg-1.min-1 (72 ± 23% of VO2max) was lower than VO2max in the lab (p = 0.04). Mean HR during skiing was 126 ± 2 bpm (77 ± 1% of HRmax from lab tests). Skiing HRpeak was 162 ± 2 bpm. This was not different from HRmax in the lab (p = 0.68). Mean LA after 30 and 75 min of skiing was not different (2.2 ± 0.8 mmol.l-1 and 2.0 ± 0.8, respectively, p = 0.71). Both LA samples during skiing were lower than lab tests (p < 0.0001). There was no difference for DBP between field and laboratory tests; however, SBP increased after 30 min of skiing to 171 ± 20 (p < 0.009) and 165 ± 17 (p < 0.003) after 75 min. These remained below the mean peak SBP determined in lab tests (218+31). Mean oxygen demand during 30 and 75 min of recreational skiing is only 45% of VO2max while mean HR is 77% of HRmax. This departure from linearity not often seen in typical aerobic activities suggests that alpine skiing requires a combination of aerobic and anaerobic activity. Blood LA remained low during skiing suggesting that elderly skiers may govern their intensity via signals closer to VO2 and LA compared to HR or BP. Key points

Kick, Glide, Pole! Cross-Country Skiing Fun (Part II)

ERIC Educational Resources Information Center

Duoos, Bridget A.

2012-01-01

Part I of Kick, Glide, Pole! Cross-Country Skiing Fun, which was published in last issue, discussed how to select cross-country ski equipment, dress for the activity and the biomechanics of the diagonal stride. Part II focuses on teaching the diagonal stride technique and begins with a progression of indoor activities. Incorporating this fun,…

[Changes in skiing accidents during the last 20 years].

PubMed

Röthlisberger, M

1990-01-01

Since 23 years the skiing-accidents are statistically surveyed in the private practice of the author. The number of injured patients is continuously decreasing. Specially the injuries in years with little snow fall are analyzed. It is evident that leg fractures are quite rare but severe injuries of the knee are increasing. 50% of ski accidents are minor injuries.

Reducing the Odds: Backcountry Powder Skiing in Avalanche Terrain.

ERIC Educational Resources Information Center

Daffern, Tony

This paper provides information and strategies to reduce the risk of encountering an avalanche when skiing or climbing on steep slopes. Skiers must recognize that the risk exists, be aware of their own tolerance for risk, and not allow companions to pressure them into taking more risk than they can tolerate. Ideally, one should ski with a small…

Kick, Glide, Pole! Cross-Country Skiing Fun (Part I)

ERIC Educational Resources Information Center

Duoos, Bridget A.

2011-01-01

Cross-country skiing is a great activity for taking a physical education class outside during the cold winter months. It is also a diverse activity that appeals to students of all ages, and is an excellent cardio-respiratory activity to keep students active. This article has provided the first steps in preparing a cross-country skiing lesson in…

Tactical Action Officer Intelligent Tutoring System (TAO ITS)

DTIC Science & Technology

2006-01-01

scenario. As well as the intrinsic feedback that free - play simulations naturally provide a student, the TAO ITS provides detailed, useful extrinsic feedback...incorporate use of free - play simulators into their curriculum, affordably. This is a major shortcoming of conventional CBT as student manipulation of...tutoring systems are ideal for incorporating desktop free - play simulators into computer-based training since the software can stand in for a human

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.

PubMed

Takeda, Masafumi; Mizuide, Masafumi; Oka, Masako; Watabe, Tetsuro; Inoue, Hirofumi; Suzuki, Hiroyuki; Fujita, Toshiro; Imamura, Takeshi; Miyazono, Kohei; Miyazawa, Keiji

2004-03-01

c-Ski is a transcriptional corepressor that interacts strongly with Smad2, Smad3, and Smad4 but only weakly with Smad1 and Smad5. Through binding to Smad proteins, c-Ski suppresses signaling of transforming growth factor-beta (TGF-beta) as well as bone morphogenetic proteins (BMPs). In the present study, we found that a mutant of c-Ski, termed c-Ski (ARPG) inhibited TGF-beta/activin signaling but not BMP signaling. Selectivity was confirmed in luciferase reporter assays and by determination of cellular responses in mammalian cells (BMP-induced osteoblastic differentiation of C2C12 cells and TGF-beta-induced epithelial-to-mesenchymal transdifferentiation of NMuMG cells) and Xenopus embryos. The ARPG mutant recruited histone deacetylases 1 (HDAC1) to the Smad3-Smad4 complex but not to the Smad1/5-Smad4 complex. c-Ski (ARPG) was unable to interact with Smad4, and the selective loss of suppression of BMP signaling by c-Ski (ARPG) was attributed to the lack of Smad4 binding. We also found that c-Ski interacted with Smad3 or Smad4 without disrupting Smad3-Smad4 heteromer formation. c-Ski (ARPG) would be useful for selectively suppressing TGF-beta/activin signaling.

Interaction with Smad4 Is Indispensable for Suppression of BMP Signaling by c-Ski

PubMed Central

Takeda, Masafumi; Mizuide, Masafumi; Oka, Masako; Watabe, Tetsuro; Inoue, Hirofumi; Suzuki, Hiroyuki; Fujita, Toshiro; Imamura, Takeshi; Miyazono, Kohei; Miyazawa, Keiji

2004-01-01

c-Ski is a transcriptional corepressor that interacts strongly with Smad2, Smad3, and Smad4 but only weakly with Smad1 and Smad5. Through binding to Smad proteins, c-Ski suppresses signaling of transforming growth factor-β (TGF-β) as well as bone morphogenetic proteins (BMPs). In the present study, we found that a mutant of c-Ski, termed c-Ski (ARPG) inhibited TGF-β/activin signaling but not BMP signaling. Selectivity was confirmed in luciferase reporter assays and by determination of cellular responses in mammalian cells (BMP-induced osteoblastic differentiation of C2C12 cells and TGF-β–induced epithelial-to-mesenchymal transdifferentiation of NMuMG cells) and Xenopus embryos. The ARPG mutant recruited histone deacetylases 1 (HDAC1) to the Smad3-Smad4 complex but not to the Smad1/5-Smad4 complex. c-Ski (ARPG) was unable to interact with Smad4, and the selective loss of suppression of BMP signaling by c-Ski (ARPG) was attributed to the lack of Smad4 binding. We also found that c-Ski interacted with Smad3 or Smad4 without disrupting Smad3-Smad4 heteromer formation. c-Ski (ARPG) would be useful for selectively suppressing TGF-β/activin signaling. PMID:14699069

The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease.

PubMed

Wong, Wai-Man R; Stephens, Jeffrey W; Acharya, Jayshree; Hurel, Steven J; Humphries, Steve E; Talmud, Philippa J

2004-08-01

Apolipoprotein A-IV (apoA-IV) has been postulated to be antiatherogenic. Transgenic APOA4/Apoe-/- mice are protected against atherosclerosis, with plasma apoA-IV displaying antioxidant activity in vitro. In humans, there is an inverse relationship between apoA-IV levels and risk of coronary heart disease (CHD). Furthermore, the APOA4 T347S rare allele has been associated with increased risk of CHD and reduced apoA-IV levels. Reduced total antioxidant status (TAOS) due to increased oxidative stress is implicated in the process of atherogenesis. Thus, this study aimed to examine the association between the APOA4 T347S variant and TAOS in diabetic patients with (n = 196) or without (n = 509) cardiovascular disease (CVD). A higher percentage of CVD patients were present in the lowest quartile of TAOS, compared with the rest (P = 0.04). Overall, there was no association between genotype and TAOS. However, in patients with CVD, homozygotes for the S347 allele had significantly lower TAOS compared with TT and TS subjects (31.2 +/- 9.89% and 42.5 +/- 13.04% TAOS, respectively; P = 0.0024), an effect that was not seen in the patients without CVD. This study offers direct support for an antioxidant capacity of apoA-IV, thus providing some explanation for the antiatherogenic role of apoA-IV and the higher CVD risk in S347 homozygotes. Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.

Downhill ski injuries in children and adolescents.

PubMed

Meyers, Michael C; Laurent, C Matthew; Higgins, Robert W; Skelly, William A

2007-01-01

Downhill skiing is considered to be an enjoyable activity for children and adolescents, but it is not without its risks and injuries. Injury rates now range between 3.9 and 9.1 injuries per 1000 skier days, and there has been a well documented increase in the number of trauma cases and fatalities associated with this sport. Head and neck injuries are considered the primary cause of fatal injuries and constitute 11-20% of total injuries among children and adolescents. Cranial trauma is responsible for up to 54% of total hospital injuries and 67% of all fatalities, whereas thoracoabdominal and spine injuries comprise 4-10% of fatalities. Furthermore, there has been an increase in the proportion of upper extremity trauma with acromioclavicular dislocations, and clavicle and humeral fractures accounting for the majority (22-79%) of the injuries. However, the most common and potentially serious injuries in children and adolescents are those to the lower extremity, with knee sprains and anterior cruciate ligament tears accounting for up to 47.7% of total injuries. Knee sprains and grade III ligament trauma associated with lower leg fractures account for 39-77% of ski injuries in this young population. Approximately 15% of downhill skiing injuries among children and adolescents are caused by musculoskeletal immaturity. Other factors include excessive fatigue, age, level of experience, and inappropriate or improperly adjusted equipment. Collisions and falls constitute a significant portion (up to 76%) of trauma, and are commonly associated with excessive speed, adverse slope conditions, overconfidence leading to carelessness, and behavioural patterns within and among gender. The type and severity of injuries are typically functions of biomechanical efficiency, skiing velocity or slope conditions; however, a multiplicative array of intrinsic and extrinsic factors may simultaneously be involved. Despite extensive efforts to provide a comprehensive picture of the aetiology of

Stretch-shortening cycle in roller ski skating: effects of technique.

PubMed

Perrey, S; Millet, G Y; Candau, R; Rouillon, J D

1998-11-01

The purposes of this study were 1) to examine the occurrence of the stretch-shortening cycle (SSC) in the three principal techniques of ski skating and 2) to test the hypothesis that differences in SSC behaviour may explain the choice of a technique when the grade is altered. Ten highly skilled male cross-country skiers roller skied at 5.3+/-0.1 m x s(-1) using the V1 skate (V1), V2-alternate (V2A), and V2 skate (V2) techniques. Knee and ankle joint kinematics, EMG of the vastus lateralis (VL) and gastrocnemius lateralis (GL) muscles, and roller ski velocity were recorded during the last 40 s of each bout of roller skiing. The existence of an EMG signal during the eccentric phase prior to the thrust, as well as the lack of significant delay between the two phases, showed that SSC occurs in the three techniques of roller ski skating with the exception of 50% of the subjects at the weak side knee with V1. The VL stretching velocity over the eccentric phase was higher (p < 0.005) with V2 and V2A than V1, indicating that less elastic energy was stored in the lower limbs extensor muscles with V1. This could partly explain why this technique is not used on flat terrains during races. However, no differences of average EMG activity or IEMG existed between techniques for either GL or VL during the concentric phase, suggesting that the theoretical advantage due to the SSC behaviour is minor in roller ski skating.

Negative regulation of BMP signaling by the ski oncoprotein.

PubMed

Luo, Kunxin

2003-01-01

The bone morphogenetic proteins (BMPs) play important roles in the regulation of multiple aspects of vertebrate development. BMPs signal through the cell surface receptors and downstream Smad molecules. Upon stimulation with BMP, Smad1, Smad5, and Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocate into the nucleus, where they regulate the expression of BMP target genes. The activity of this signal pathway can be modulated both by extracellular factors that regulate the binding of BMPs to the receptor and by intracellular proteins that interact with the Smad proteins. We have shown that Ski is an important negative regulator of the Smad proteins. Ski can bind to the BMP-Smad protein complexes in response to BMP and repress their ability to activate BMP target genes through disruption of a functional Smad complex and through recruitment of transcriptional co-repressors. The antagonism of BMP signaling by Ski results in neural specification in Xenopus embryos and inhibition of osteoblast differentiation in mouse bone-marrow stromal progenitor cells. This ability to modulate BMP signaling by Ski may play an important role in the regulation of craniofacial, neuronal, and skeletal muscle development.

Ski Inhibits TGF-β/phospho-Smad3 Signaling and Accelerates Hypertrophic Differentiation in Chondrocytes

PubMed Central

Kim, Kyung-Ok; Sampson, Erik R.; Maynard, Robert D; O'Keefe, Regis J.; Chen, Di; Drissi, Hicham; Rosier, Randy N.; Hilton, Matthew J.; Zuscik, Michael J.

2012-01-01

Since TGF-β/Smad signaling inhibits chondrocyte maturation, endogenous negative regulators of TGF-β signaling are likely also important regulators of the chondrocyte differentiation process. One such negative regulator, Ski, is an oncoprotein that is known to inhibit TGF-β/Smad3 signaling via its interaction with phospho-Smad3 and recruitment of histone deacetylases (HDACs) to the DNA binding complex. Based on this, we hypothesized that Ski inhibits TGF-β signaling and accelerates maturation in chondrocytes via recruitment of HDACs to transcriptional complexes containing Smads. We tested this hypothesis in chick upper sternal chondrocytes (USCs), where gain and loss of Ski expression experiments were performed. Over-expression of Ski not only reversed the inhibitory effect of TGF-β on the expression of hypertrophic marker genes such as type × collagen (colX) and osteocalcin, it induced these genes basally as well. Conversely, knockdown of Ski by RNA interference led to a reduction of colX and osteocalcin expression under basal conditions. Furthermore, Ski blocked TGF-β induction of cyclinD1 and caused a basal up-regulation of Runx2, consistent with the observed acceleration of hypertrophy. Regarding mechanism, not only does Ski associate with phospho-Smad2 and 3, but its association with phospho-Smad3 is required for recruitment of HDAC4 and 5. Implicating this recruitment of HDACs in the phenotypic effects of Ski in chondrocytes, the HDAC inhibitor SAHA reversed the up-regulation of colX and osteocalcin in Ski over-expressing cells. These results suggest that inhibition of TGF-β signaling by Ski, which involves its association with phospho-Smad3 and recruitment of HDAC4 and 5, leads to accelerated chondrocyte differentiation. PMID:22461172

Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.

PubMed

Arndt, Stephanie; Poser, Ina; Moser, Markus; Bosserhoff, Anja-Katrin

2007-04-01

The Ski family of nuclear oncoproteins represses transforming growth factor-beta (TGF-beta) signaling through inhibition of transcriptional activity of Smad proteins. In this study, we identified a novel gene, fussel-15 (functional smad suppressing element on chromosome 15) with high homology to the recently discovered Fussel-18 protein. Both, Fussel-15 and Fussel-18, share important structural features, significant homology and similar genomic organization with the homolog Ski family members, Ski and SnoN. Unlike Ski and SnoN, which are ubiquitously expressed in human tissues, Fussel-15 expression, like Fussel-18, is much more restricted in its expression and is principally found in the nervous system of mouse and humans. Interestingly, Fussel-15 expression is even more restricted in adulthood to Purkinje cells of human cerebellum. In contrast to Fussel-18 that interacts with Smad 2, Smad3 and Smad4 and has an inhibitory activity on TGF-beta signaling, Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signaling pathway but has only minor effects on TGF-beta signaling. This new protein expands the family of Ski/Sno proto-oncoproteins and represents a novel molecular regulator of BMP signaling.

High Performance Skiing. How to Become a Better Alpine Skier.

ERIC Educational Resources Information Center

Yacenda, John

This book is intended for people who desire to improve their skiing by exploring high performance techniques leading to: (1) more consistent performance; (2) less fatigue and more endurance; (3) greater strength and flexibility; (4) greater versatility; (5) greater confidence in all skiing conditions; and (6) the knowledge to participate in…

Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer

PubMed Central

Chen, Yi; Pirisi, Lucia; Creek, Kim E.

2013-01-01

We compared the levels of the Ski oncoprotein, an inhibitor of transforming growth factor-beta (TGF-β) signaling, in normal human keratinocytes (HKc), HPV16 immortalized HKc (HKc/HPV16), and differentiation resistant HKc/HPV16 (HKc/DR) in the absence and presence of TGF-β. Steady-state Ski protein levels increased in HKc/HPV16 and even further in HKc/DR, compared to HKc. TGF-β treatment of HKc, HKc/HPV16, and HKc/DR dramatically decreased Ski. TGF-β-induced Ski degradation was delayed in HKc/DR. Ski and phospho-Ski protein levels are cell cycle dependent with maximal Ski expression and localization to centrosomes and mitotic spindles during G2/M. ShRNA knock down of Ski in HKc/DR inhibited cell proliferation. More intense nuclear and cytoplasmic Ski staining and altered Ski localization were found in cervical cancer samples compared to adjacent normal tissue in a cervical cancer tissue array. Overall, these studies demonstrate altered Ski protein levels, degradation and localization in HPV16-transformed human keratinocytes and in cervical cancer. PMID:23809940

Ski areas affect Pacific marten movement, habitat use, and density

Treesearch

Keith M. Slauson; William J. Zielinski; Michael K. Schwartz

2017-01-01

Alpine ski recreation is one of the most popular outdoor winter sports globally but often involves habitat modification and dense human activity, both of which can harm wildlife. We investigated the effects of ski area development and winter recreation activities on movement, occupancy, and density of Pacific martens (Martes caurina) in the Lake...

Taos Smart Growth Implementation Assistance: Concepts for the Paseo del Pueblo Sur Corridor

EPA Pesticide Factsheets

This report describes a technical assistance project with Taos, NM, to help make development along State Highway 68, the Paseo del Pueblo Sur commercial corridor, economically stronger and more attractive.

A microcomputer controlled snow ski binding system--I. Instrumentation and field evaluation.

PubMed

MacGregor, D; Hull, M L; Dorius, L K

1985-01-01

This paper presents the design and field evaluation of the first microcomputer controlled ski binding system. This system incorporates an Intel 8086 microcomputer controller and an integral binding/dynamometer. This instrumentation system not only undertakes real time control, but also it records dynamometer data via a miniature digital cassette tape recorder. The integral binding/dynamometer offers the same operational and mounting convenience of commercially available mechanical bindings. The binding may be released either manually or electrically via the controller. Comprised of four octagonal half strain rings, the strain gage dynamometer measures the three moment load components at the boot. To enable the user to conveniently operate the computer, extensive operating software was developed. The operating software is discussed in relation to both the acquisition and storage of data from the dynamometer and the control of the electro-mechanical snow ski binding. The binding system has been used successfully to both record boot moment components and control ski binding release during actual skiing maneuvers. Moment histories typical of three common recreational skiing maneuvers are presented.

Ergonomic analyses of downhill skiing.

PubMed

Clarys, J P; Publie, J; Zinzen, E

1994-06-01

The purpose of this study was to provide electromyographic feedback for (1) pedagogical advice in motor learning, (2) the ergonomics of materials choice and (3) competition. For these purposes: (1) EMG data were collected for the Stem Christie, the Stem Turn and the Parallel Christie (three basic ski initiation drills) and verified for the complexity of patterns; (2) integrated EMG (iEMG) and linear envelopes (LEs) were analysed from standardized positions, motions and slopes using compact, soft and competition skis; (3) in a simulated 'parallel special slalom', the muscular activity pattern and intensity of excavated and flat snow conditions were compared. The EMG data from the three studies were collected on location in the French Alps (Tignes). The analog raw EMG was recorded on the slopes with a portable seven-channel FM recorder (TEAC MR30) and with pre-amplified bipolar surface electrodes supplied with a precision instrumentation amplifier (AD 524, Analog Devices, Norwood, USA). The raw signal was full-wave rectified and enveloped using a moving average principle. This linear envelope was normalized according to the highest peak amplitude procedure per subject and was integrated in order to obtain a reference of muscular intensity. In the three studies and for all subjects (elite skiers: n = 25 in studies 1 and 2, n = 6 in study 3), we found a high level of co-contractions in the lower limb extensors and flexors, especially during the extension phase of the ski movement. The Stem Christie and the Parallel Christie showed higher levels of rhythmic movement (92 and 84%, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

The importance of being light: aerodynamic forces and weight in ski jumping.

PubMed

Schmölzer, B; Müller, W

2002-08-01

Many contemporary world class ski jumpers are alarmingly underweight and several cases of anorexia nervosa have come to light. Athletes strive for low body weight because it gives them a major competitive advantage. In order to stop this hazardous development, changes to the regulations are being discussed, and the International Ski Federation and the International Olympic Committee wish to be proactive in safe guarding the interest of the athletes and their health. This study of ski jumping uses field studies conducted during World Cup competitions, large-scale wind tunnel measurements with 1:1 models of ski jumpers in current equipment and highly accurate computer simulations of the flight phase that include the effects due to the athlete's position changes. Particular attention has been directed to the design of a reference jump that mirrors current flight style and equipment regulations (2001), and to the investigation of effects associated with variation in body mass, air density, and wind gusts during the simulated flight. The detailed analysis of the physics of ski jumping described here can be used for the investigation of all initial value and parameter variations that determine the flight path of a ski jumper and will form a reliable basis for setting regulations that will make it less attractive or even disadvantageous for the athlete to be extremely light.

Skiing economy and efficiency in recreational and elite cross-country skiers.

PubMed

Ainegren, Mats; Carlsson, Peter; Tinnsten, Mats; Laaksonen, Marko S

2013-05-01

The purpose of this study was to investigate and compare skiing economy and gross efficiency in cross-country skiers of different performance levels, ages and genders; male recreational skiers and elite senior and junior cross-country skiers of both genders. The skiers performed tests involving roller skiing on a treadmill using the gear 3 and diagonal stride techniques. The elite cross-country skiers were found to have better skiing economy and higher gross efficiency (5-18%) compared with the recreational skiers (p < 0.05) and the senior elite had better economy and higher efficiency (4-5%) than their junior counterparts (p < 0.05), whereas no differences could be found between the genders. Also, large ranges in economy and gross efficiency were found in all groups. It was concluded that, in addition to V[Combining Dot Above]O2peak, skiing economy and gross efficiency have a great influence on the differences in performance times between recreational and junior and senior elite cross-country skiers, as well as between individual skiers within the different categories. Thus, we recommend cross-country skiers at all performance levels to test not only V[Combining Dot Above]O2peak, but also skiing economy and efficiency.

Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation

PubMed Central

Zhang, Song; Takaku, Motoki; Zou, Liyun; Gu, Ai-di; Chou, Wei-chun; Zhang, Ge; Wu, Bing; Kong, Qing; Thomas, Seddon Y.; Serody, Jonathan S.; Chen, Xian; Xu, Xiaojiang; Wade, Paul A.; Cook, Donald N.; Ting, Jenny P.; Wan, Yisong Y.

2017-01-01

Th17 cells are critically involved in host defense, inflammation, and autoimmunity1–5. TGF-β is instrumental in Th17 differentiation by cooperating with IL-66,7. Yet, the mechanism of how TGF-β enables Th17 differentiation remains elusive. Here we reveal that TGF-β licenses Th17 differentiation by releasing Ski-Smad4-complex suppressed RORγt expression. We found serendipitously that, unlike wild-type T cells, Smad4-deficient T cells differentiated into Th17 cells in the absence of TGF-β signaling in a RORγt-dependent manner. Ectopic Smad4 expression suppressed the RORγt expression and Th17 differentiation of Smad4-deficient T cells. Unexpectedly however, TGF-β neutralized Smad4 mediated suppression without affecting Smad4 binding to Rorc locus. Proteomic analysis revealed that Smad4 interacted with Ski, a transcriptional repressor degraded upon TGF-β stimulation. Ski controlled the histone acetylation/de-acetylation of Rorc locus and Th17 differentiation via Smad4 because ectopic Ski expression inhibited H3K9Ac of Rorc locus, Rorc expression and Th17 differentiation in a Smad4-dependent manner. Therefore, TGF-β-induced disruption of Ski releases Ski-Smad4 complex imposed suppression of RORγt to license Th17 differentiation. This study reveals a critical mechanism by which TGF-β controls Th17 differentiation and uncovers Ski-Smad4 axis as a potential therapeutic target for treating Th17 related diseases. PMID:29072299

In-Frame Mutations in Exon 1 of SKI Cause Dominant Shprintzen-Goldberg Syndrome

PubMed Central

Carmignac, Virginie; Thevenon, Julien; Adès, Lesley; Callewaert, Bert; Julia, Sophie; Thauvin-Robinet, Christel; Gueneau, Lucie; Courcet, Jean-Benoit; Lopez, Estelle; Holman, Katherine; Renard, Marjolijn; Plauchu, Henri; Plessis, Ghislaine; De Backer, Julie; Child, Anne; Arno, Gavin; Duplomb, Laurence; Callier, Patrick; Aral, Bernard; Vabres, Pierre; Gigot, Nadège; Arbustini, Eloisa; Grasso, Maurizia; Robinson, Peter N.; Goizet, Cyril; Baumann, Clarisse; Di Rocco, Maja; Sanchez Del Pozo, Jaime; Huet, Frédéric; Jondeau, Guillaume; Collod-Beroud, Gwenaëlle; Beroud, Christophe; Amiel, Jeanne; Cormier-Daire, Valérie; Rivière, Jean-Baptiste; Boileau, Catherine; De Paepe, Anne; Faivre, Laurence

2012-01-01

Shprintzen-Goldberg syndrome (SGS) is characterized by severe marfanoid habitus, intellectual disability, camptodactyly, typical facial dysmorphism, and craniosynostosis. Using family-based exome sequencing, we identified a dominantly inherited heterozygous in-frame deletion in exon 1 of SKI. Direct sequencing of SKI further identified one overlapping heterozygous in-frame deletion and ten heterozygous missense mutations affecting recurrent residues in 18 of the 19 individuals screened for SGS; these individuals included one family affected by somatic mosaicism. All mutations were located in a restricted area of exon 1, within the R-SMAD binding domain of SKI. No mutation was found in a cohort of 11 individuals with other marfanoid-craniosynostosis phenotypes. The interaction between SKI and Smad2/3 and Smad 4 regulates TGF-β signaling, and the pattern of anomalies in Ski-deficient mice corresponds to the clinical manifestations of SGS. These findings define SGS as a member of the family of diseases associated with the TGF-β-signaling pathway. PMID:23103230

Audiomagnetotelluric data, Taos Plateau Volcanic Field, New Mexico

USGS Publications Warehouse

Ailes, Chad E.; Rodriguez, Brian D.

2011-01-01

The U.S. Geological Survey is conducting a series of multidisciplinary studies of the San Luis Basin as part of the Geologic framework of the Rio Grande Basins project. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, audiomagnetotelluric surveys, and hydrologic and lithologic data are being used to better understand the aquifers. This report describes a regional east-west audiomagnetotelluric sounding profile acquired in late July 2009 across the Taos Plateau Volcanic Field. No interpretation of the data is included.

Effect of ski geometry and standing height on kinetic energy: equipment designed to reduce risk of severe traumatic injuries in alpine downhill ski racing

PubMed Central

Gilgien, Matthias; Spörri, Jörg; Kröll, Josef; Müller, Erich

2016-01-01

Background Injuries in downhill (DH) are often related to high speed and, therefore, to high energy and forces which are involved in injury situations. Yet to date, no study has investigated the effect of ski geometry and standing height on kinetic energy (EKIN) in DH. This knowledge would be essential to define appropriate equipment rules that have the potential to protect the athletes’ health. Methods During a field experiment on an official World Cup DH course, 2 recently retired world class skiers skied on 5 different pairs of skis varying in width, length and standing height. Course characteristics, terrain and the skiers’ centre of mass position were captured by a differential Global Navigational Satellite System-based methodology. EKIN, speed, ski–snow friction force (FF), ground reaction force (FGRF) and ski–snow friction coefficient (CoeffF) were calculated and analysed in dependency of the used skis. Results In the steep terrain, longer skis with reduced width and standing height significantly decreased average EKIN by ∼3%. Locally, even larger reductions of EKIN were observed (up to 7%). These local decreases in EKIN were mainly explainable by higher FF. Moreover, CoeffF differences seem of greater importance for explaining local FF differences than the differences in FGRF. Conclusions Knowing that increased speed and EKIN likely lead to increased forces in fall/crash situations, the observed equipment-induced reduction in EKIN can be considered a reasonable measure to improve athlete safety, even though the achieved preventative gains are rather small and limited to steep terrain. PMID:26702013

Overexpression of SKI Oncoprotein Leads to p53 Degradation through Regulation of MDM2 Protein Sumoylation*

PubMed Central

Ding, Boxiao; Sun, Yin; Huang, Jiaoti

2012-01-01

Protooncogene Ski was identified based on its ability to transform avian fibroblasts in vitro. In support of its oncogenic activity, SKI was found to be overexpressed in a variety of human cancers, although the exact molecular mechanism(s) responsible for its oncogenic activity is not fully understood. We found that SKI can negatively regulate p53 by decreasing its level through up-regulation of MDM2 activity, which is mediated by the ability of SKI to enhance sumoylation of MDM2. This stimulation of MDM2 sumoylation is accomplished through a direct interaction of SKI with SUMO-conjugating enzyme E2, Ubc9, resulting in enhanced thioester bond formation and mono-sumoylation of Ubc9. A mutant SKI defective in transformation fails to increase p53 ubiquitination and is unable to increase MDM2 levels and to increase mono-sumoylation of Ubc9, suggesting that the ability of SKI to enhance Ubc9 activity is essential for its transforming function. These results established a detailed molecular mechanism that underlies the ability of SKI to cause cellular transformation while unraveling a novel connection between sumoylation and tumorigenesis, providing potential new therapeutic targets for cancer. PMID:22411991

The effects of poling on physiological, kinematic and kinetic responses in roller ski skating.

PubMed

Grasaas, Erik; Hegge, Ann Magdalen; Ettema, Gertjan; Sandbakk, Øyvind

2014-09-01

We investigated the effects of poling on physiological, kinematic and kinetic responses in the G4 skating technique where the poling movement is synchronized with the leg push-off on one side (strong side) followed by a forward arm swing during the leg push-off on the other side (weak side). G4 skating with (G4-P) and without (G4-NP) poling was compared in 17 elite male cross-country skiers during 4-min submaximal tests on a 2% inclined roller ski treadmill at 10, 15 and 20 km h(-1). G4-P demonstrated less ventilatory stress and higher gross efficiency compared to G4-NP at all velocities, and the blood lactate concentration was lower at the high velocity (all P < 0.05). Furthermore, longer cycle lengths and lower cycle rates were found with G4-P at all velocities, with correspondingly lower peak ski forces, increased ski velocities and less angling and edging of the skis (all P < 0.05). The peak ski forces on the strong side were lower than on the weak side with G4-P at all velocities (all P < 0.05), but no differences between the sides were found with G4-NP. The reduced physiological cost, higher gross efficiency and longer cycle lengths together with the lower ski forces at a given work rate with G4-P demonstrate the effectiveness of poling in the G4 skating technique. Thus, poling provides possibilities to increase total propulsion, to reduce ski forces and to enhance skiing efficiency.

Anterior cruciate ligament injury/reinjury in alpine ski racing: a narrative review

PubMed Central

Jordan, Matthew J; Aagaard, Per; Herzog, Walter

2017-01-01

The purpose of the present review was to: 1) provide an overview of the current understanding on the epidemiology, etiology, risk factors, and prevention methods for anterior cruciate ligament (ACL) injury in alpine ski racing; and 2) provide an overview of what is known pertaining to ACL reinjury and return to sport after ACL injury in alpine ski racing. Given that most of the scientific studies on ACL injuries in alpine ski racing have been descriptive, and that very few studies contributed higher level scientific evidence, a nonsystematic narrative review was employed. Three scholarly databases were searched for articles on ACL injury or knee injury in alpine ski racing. Studies were classified according to their relevance in relation to epidemiology, etiology, risk factors, and return to sport/reinjury prevention. Alpine ski racers (skiers) were found to be at high risk for knee injuries, and ACL tears were the most frequent diagnosis. Three primary ACL injury mechanism were identified that involved tibial internal rotation and anteriorly directed shear forces from ski equipment and the environment. While trunk muscle strength imbalance and genetics were found to be predictive of ACL injuries in development-level skiers, there was limited scientific data on ACL injury risk factors among elite skiers. Based on expert opinion, research on injury risk factors should focus on equipment design, course settings/speed, and athlete factors (eg, fitness). While skiers seem to make a successful recovery following ACL injury, there may be persistent neuromuscular deficits. Future research efforts should be directed toward prospective studies on ACL injury/reinjury prevention in both male and female skiers and toward the effects of knee injury on long-term health outcomes, such as the early development of osteoarthritis. International collaborations may be necessary to generate sufficient statistical power for ACL injury/reinjury prevention research in alpine ski racing

Pt nanoparticle on La0.02Na0.98TaO3 catalyst for hydrogen evolution from glycerol aqueous solution

NASA Astrophysics Data System (ADS)

Husin, Husni; Adisalamun, Sy, Yuliana; Asnawi, Teku Muhammad; Hasfita, Fikri

2017-01-01

Pt nanoparticles on La-doped sodium tantalum oxide (La0.02Na0.98TaO3), which acts as an active co-catalyst for H2 evolution under UV light irradiation was successfully synthesized by photo-deposition method. The La0.02Na0.98TaO3 photocatalyst was obtained by the reaction of La(NO3)2.3H2O, TaCl5, and NaOH at ambient temperature. The catalyst produced was characterized by a scanning electron microscope (SEM) and a high-resolution transmission electron microscope (HRTEM). SEM images of the La0.02Na0.98TaO3 sample showing that its particles size is ranging between 50-150 nm. The Pt particles are detected from HRTEM images is around 2-4 nm. The Pt/La0.02Na0.98TaO3 samples prepared were applied for photocatalytic H2 production at 30°C. The photocatalyst performance was evaluated for hydrogen production from water combining with glycerol as an electron donor (sacrificial reagent). The reactions were carried out in a closed reactor with a gas circulation system, illuminated with mercury (Hg) lamp. The experimental results show that the presence of glycerol in the systems can not only improve the efficiency of photocatalytic hydrogen generation but can also be decomposed to hydrogen efficiently. The photocatalytic activity of La0.02Na0.98TaO3 is significantly enhanced when Pt was loaded onto its crystalline surface.

Grade influences blood lactate kinetics during cross-country skiing.

PubMed

LaRoche, Dain P; Amann, Markus; Rundell, Kenneth W

2010-01-01

The purpose of this study was to examine the effects of level vs. graded skate skiing on capillary blood lactate (B(La)), heart rate (HR), oxygen consumption (V(O2)), and training intensity prescriptions. Eleven Nordic skiers completed 2 submaximal skate roller skiing treadmill protocols during which intensity was increased either by grade (G(inc)) or by speed (S(inc)). The protocols were compared for prethreshold BLa, HR, and V(O2) at lactate threshold (LT) and the HR/V(O2) relationship. Additionally, double-pole (primarily upper body) and skating (arms and legs combined) protocols were used to measure peak V(O2) and peak HR. Heart rate and V(O2) at LT were lower during G(inc) compared with S(inc) (154.9 +/- 6.8 b.min(-1) vs. 162.0 +/- 9.1 b.min(-1) and 46.3 +/- 2.8 ml.kg(-1).min(-1) vs. 49.1 +/- 1.6 ml.kg(-1).min(-1), respectively, both p < 0.01). Pre-threshold B(La) and the HR/V(O2) relationship were not different between the submaximal protocols. V(O2) and HRpeak were higher in skating compared with double poling (64.6 +/- 1.8 ml.kg(-1).min(-1) vs. 60.3 +/- 2.8 ml.kg(-1).min(-1), 192.6 +/- 5.8 b.min(-1) vs. 187.8 +/- 6.7 b.min(-1), respectively, both p < 0.01). Greater reliance on upper-body musculature during graded skiing and its associated lower aerobic capacity increases B(La) when compared with level skiing. The leftward shift in the B(La) vs. intensity curve during uphill skiing should be recognized to properly prescribe training intensity as well as interpret laboratory results.

Vulnerability assessment of skiing-dependent businesses to the effects of climate change in Banff and Jasper National Parks, Canada

NASA Astrophysics Data System (ADS)

Reynolds, David Michael

This qualitative study examines the potential positive and negative socio-economic impacts that may emerge from the long-term effects of climate change on skiing-dependent businesses in Banff and Jasper National Parks, Canada. My goal was to determine whether or not skiing-related tourism in the parks in the 2020s and 2050s is more or less socio-economically vulnerable to the effects of climate change on snow cover, temperatures and ski season length at ski resorts in the parks. My study explored the level of awareness and personal perceptions of 60 skiing-dependent business managers about how the impact of climate change on ski resorts may influence future socio-economics of ski tourism businesses. I employed a vulnerability assessment approach and adopted some elements of grounded theory. My primary data sources are interviews with managers and the outcome of the geographical factors index (GFI). Supporting methods include: an analysis and interpretation of climate model data and an interpretation of the economic analysis of skiing in the parks. The interview data were sorted and coded to establish concepts and findings by interview questions, while the GFI model rated and ranked 24 regional ski resorts in the Canadian Cordillera. The findings answered the research questions and helped me conclude what the future socio-economic vulnerability may be of skiing-dependent businesses in the parks. The interviews revealed that managers are not informed about climate change and they have not seen any urgency to consider the effects on business. The GFI revealed that the ski resorts in the parks ranked in the top ten of 24 ski resorts in the Cordillera based on 14 common geographical factors. The economic reports suggest skiing is the foundation of the winter economy in the parks and any impact on skiing would directly impact other skiing-dependent businesses. Research indicates that the effects of climate change may have less economic impact on skiing

The Evolution of Oscillatory Behavior during Learning on a Ski Simulator

ERIC Educational Resources Information Center

Teulier, Caroline; Nourrit, Deborah; Delignieres, Didier

2006-01-01

Recent experiments on the ski simulator produced ambiguous results and raised unanswered questions concerning the true nature of "novice" behavior and the occurrence of behavioral changes during learning. The aim of the present experiment was to analyze the evolving behavior of three beginners during six practice sessions on a ski simulator. The…

In-frame mutations in exon 1 of SKI cause dominant Shprintzen-Goldberg syndrome.

PubMed

Carmignac, Virginie; Thevenon, Julien; Adès, Lesley; Callewaert, Bert; Julia, Sophie; Thauvin-Robinet, Christel; Gueneau, Lucie; Courcet, Jean-Benoit; Lopez, Estelle; Holman, Katherine; Renard, Marjolijn; Plauchu, Henri; Plessis, Ghislaine; De Backer, Julie; Child, Anne; Arno, Gavin; Duplomb, Laurence; Callier, Patrick; Aral, Bernard; Vabres, Pierre; Gigot, Nadège; Arbustini, Eloisa; Grasso, Maurizia; Robinson, Peter N; Goizet, Cyril; Baumann, Clarisse; Di Rocco, Maja; Sanchez Del Pozo, Jaime; Huet, Frédéric; Jondeau, Guillaume; Collod-Beroud, Gwenaëlle; Beroud, Christophe; Amiel, Jeanne; Cormier-Daire, Valérie; Rivière, Jean-Baptiste; Boileau, Catherine; De Paepe, Anne; Faivre, Laurence

2012-11-02

Shprintzen-Goldberg syndrome (SGS) is characterized by severe marfanoid habitus, intellectual disability, camptodactyly, typical facial dysmorphism, and craniosynostosis. Using family-based exome sequencing, we identified a dominantly inherited heterozygous in-frame deletion in exon 1 of SKI. Direct sequencing of SKI further identified one overlapping heterozygous in-frame deletion and ten heterozygous missense mutations affecting recurrent residues in 18 of the 19 individuals screened for SGS; these individuals included one family affected by somatic mosaicism. All mutations were located in a restricted area of exon 1, within the R-SMAD binding domain of SKI. No mutation was found in a cohort of 11 individuals with other marfanoid-craniosynostosis phenotypes. The interaction between SKI and Smad2/3 and Smad 4 regulates TGF-β signaling, and the pattern of anomalies in Ski-deficient mice corresponds to the clinical manifestations of SGS. These findings define SGS as a member of the family of diseases associated with the TGF-β-signaling pathway. Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

The physiological and biomechanical contributions of poling to roller ski skating.

PubMed

Sandbakk, Øyvind; Ettema, Gertjan; Holmberg, Hans-Christer

2013-08-01

Poling is considered to make a significant contribution to cross-country skiing with the skating technique. To better understand this contribution, the current investigation compared roller ski skating on a treadmill with the so-called G3 skating technique with (G3-P) and without poling (G3-NP). Seven male elite skiers performed 5-min submaximal tests at 8, 12, and 15 km h(-1), as well as an incremental test to exhaustion with both techniques on a 5 % incline. Ventilatory variables were assessed by open-circuit indirect calorimetry and three-dimensional kinematics analyzed using the Qualisys Pro Reflex system. G3-P was associated with approximately 15 % higher peak velocity and 10 % higher peak oxygen uptake than G3-NP in the incremental test (both P < 0.01). All ventilatory variables, as well as heart rate and blood lactate concentration were lower with G3-P as compared to G3-NP at 12 and 15 km h(-1) (all P < 0.01). Gross efficiency (i.e., the ratio of work rate to metabolic rate) at 12 km h(-1) was higher in G3-P (14.9 %) than G3-NP (13.5 %) (P < 0.01). Moreover, with G3-P cycle time and length were both 30 % longer, with correspondingly reduced cycle rates (all P < 0.01). In addition, the ski gliding and swing phases were longer and the angle between the skis smaller with G3-P (both P < 0.01), whereas the push-off time was independent of technique and velocity. Taken together, these results indicate that poling makes an important contribution to propulsion and velocity during ski skating, specifically by enhancing peak oxygen uptake, skiing efficiency and associated biomechanical variables.

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.

PubMed

Suzuki, Hiroyuki; Yagi, Ken; Kondo, Miki; Kato, Mitsuyasu; Miyazono, Kohei; Miyazawa, Keiji

2004-06-24

c-Ski inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. c-Ski represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. c-Ski also inhibits TGF-beta-induced downregulation of genes such as c-myc. However, mechanisms for transcriptional regulation of target genes by c-Ski have not been fully determined. In this study, we examined how c-Ski inhibits both TGF-beta-induced transcriptional activation and repression. DNA-affinity precipitation analysis revealed that c-Ski enhances the binding of Smad2 and 4, and to a lesser extent Smad3, to both CAGA and TGF-beta1 inhibitory element probes. A c-Ski mutant, which is unable to interact with Smad4, failed to enhance the binding of Smad complex on these probes and to inhibit the Smad-responsive promoter. These results suggest that stabilization of inactive Smad complexes on DNA is a critical event in c-Ski-mediated inhibition of TGF-beta signaling.

Tank Investigation of the Grumman JRF-5 Airplane Equipped with Twin Hydro-Skis TED No. NACA DE 357

NASA Technical Reports Server (NTRS)

Ramsen, John A.; Gray, George R.

1951-01-01

A tank investigation has been conducted on a 1/8-size powered dynamic model of the Grumman JRF-5 airplane equipped with twin hydro-skis. The results of tests using two types of skis are presented: one had vertical sides joining the top surface to the chine; the other had the top surface faired to the chine to eliminate the vertical sides. Both configurations had satisfactory longitudinal stability although the model had a slightly greater stable elevator range available when the skis without the vertical sides were attached. Free model tests indicated no instability present when one ski emerged before the other. Considerable excess thrust was available at all speeds with either type of skis. A hump gross load-resistance ratio of 3.37 was obtained with the skis with the vertical sides and 3.53 with the other skis. Landing behavior in smooth water with yaw up to 15deg and roll up to 15deg in opposite directions was satisfactory with either type of skis.

Enhanced UV exposure on a ski-field compared with exposures at sea level.

PubMed

Allen, Martin; McKenzie, Richard

2005-05-01

Personal erythemal UV monitoring badges, which were developed to monitor the UV exposure of school children, were used to measure UV exposures received by one of the authors (MA) at the Mt Hutt ski-field, in New Zealand. These were then compared with measurements taken at the same times from a nearby sea level site in Christchurch city. The badges were designed to give instantaneous readings of erythemally-weighted (i.e., "sun burning") UV radiation and were cross-calibrated against meteorological grade UV instruments maintained by the National Institute of Water & Atmospheric Research (NIWA). All skiing and calibration days were clear and almost exclusively cloud free. It was found that the UV maxima for horizontal surfaces at the ski-field (altitude approximately 2 km) were 20-30% greater than at the low altitude site. Larger differences between the sites were observed when the sensor was oriented perpendicular to the sun. The personal doses of UV received by a sensor on the skier's lapel during two days of skiing activity were less than those received by a stationary detector on a horizontal surface near sea level. The exposures depended strongly on the time of year, and in mid-October the maximum UV intensity on the ski-field was 60% greater than in mid-September. The UV exposure levels experienced during skiing were smaller than the summer maxima at low altitudes.

Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.

PubMed

Zhang, Song; Takaku, Motoki; Zou, Liyun; Gu, Ai-di; Chou, Wei-Chun; Zhang, Ge; Wu, Bing; Kong, Qing; Thomas, Seddon Y; Serody, Jonathan S; Chen, Xian; Xu, Xiaojiang; Wade, Paul A; Cook, Donald N; Ting, Jenny P Y; Wan, Yisong Y

2017-11-02

T helper 17 (T H 17) cells are critically involved in host defence, inflammation, and autoimmunity. Transforming growth factor β (TGFβ) is instrumental in T H 17 cell differentiation by cooperating with interleukin-6 (refs 6, 7). Yet, the mechanism by which TGFβ enables T H 17 cell differentiation remains elusive. Here we reveal that TGFβ enables T H 17 cell differentiation by reversing SKI-SMAD4-mediated suppression of the expression of the retinoic acid receptor (RAR)-related orphan receptor γt (RORγt). We found that, unlike wild-type T cells, SMAD4-deficient T cells differentiate into T H 17 cells in the absence of TGFβ signalling in a RORγt-dependent manner. Ectopic SMAD4 expression suppresses RORγt expression and T H 17 cell differentiation of SMAD4-deficient T cells. However, TGFβ neutralizes SMAD4-mediated suppression without affecting SMAD4 binding to the Rorc locus. Proteomic analysis revealed that SMAD4 interacts with SKI, a transcriptional repressor that is degraded upon TGFβ stimulation. SKI controls histone acetylation and deacetylation of the Rorc locus and T H 17 cell differentiation via SMAD4: ectopic SKI expression inhibits H3K9 acetylation of the Rorc locus, Rorc expression, and T H 17 cell differentiation in a SMAD4-dependent manner. Therefore, TGFβ-induced disruption of SKI reverses SKI-SMAD4-mediated suppression of RORγt to enable T H 17 cell differentiation. This study reveals a critical mechanism by which TGFβ controls T H 17 cell differentiation and uncovers the SKI-SMAD4 axis as a potential therapeutic target for treating T H 17-related diseases.

Effect of SKI2670, a novel, orally active, non-peptide GnRH antagonist, on hypothalamic-pituitary-gonadal axis.

PubMed

Kim, Seon Mi; Yoo, Taekyung; Lee, So Young; Kim, Eun Jeong; Lee, Soo Min; Lee, Min Hee; Han, Min Young; Jung, Seung-Hyun; Choi, Jung-Hye; Ryu, Keun Ho; Kim, Hun-Taek

2015-10-15

Suppression of the hypothalamic-pituitary-gonadal axis has been widely utilized for the management of gonadal-hormone-dependent diseases such as endometriosis. Efforts to develop orally available gonadotropin-releasing hormone (GnRH) antagonists for the treatment of gonadal-hormone-dependent diseases led to the discovery of SKI2670, a novel non-peptide GnRH antagonist. The present study was undertaken to pharmacologically characterize SKI2670 in vitro and in vivo. We measured binding affinity and antagonistic activity of SKI2670 for the GnRH receptors. Immediate suppression of gonadotropins by single dosing of SKI2670 was examined in castrated monkeys. Subsequently, influence on gonadal hormones by prolonged administration of SKI2670 was assessed in naive female monkeys. To investigate in vivo efficacy of SKI2670, regression of ectopic implants by repeated administration of SKI2670 was examined in a rat endometriosis model. SKI2670 is a potent functional antagonist for the human GnRH receptor, with subnanomolar binding affinity. In castrated monkeys, single administration of SKI2670 lowered serum luteinizing hormone (LH) levels stronger with longer duration when compared to elagolix at equivalent doses. Moreover, repeated dosing of SKI2670 suppressed serum levels of gonadotropins and gonadal hormones in intact female monkeys while elagolix suppressed serum LH levels only. Finally, it exhibited regressive effects on ectopic implants in a rat endometriosis model without bone loss. Our findings demonstrate robust GnRH antagonistic efficacy of SKI2670 in animal models, suggesting that SKI2670-induced suppression of the hypothalamic-pituitary-gonadal axis may be beneficial for the treatment of gonadal-hormone-dependent diseases such as endometriosis in humans. Copyright © 2015 Elsevier Inc. All rights reserved.

Multi-Axis Prosthetic Knee Resembles Alpine Skiing Movements of an Intact Leg

PubMed Central

Demšar, Ivan; Duhovnik, Jože; Lešnik, Blaž; Supej, Matej

2015-01-01

The purpose of the study was to analyse the flexion angles of the ski boot, ankle and knee joints of an above-knee prosthesis and to compare them with an intact leg and a control group of skiers. One subject with an above-knee amputation of the right leg and eight healthy subjects simulated the movement of a skiing turn by performing two-leg squats in laboratory conditions. By adding additional loads in proportion to body weight (BW; +1/3 BW, +2/3 BW, +3/3 BW), various skiing regimes were simulated. Change of Flexion Angle (CoFA) and Range of Motion (RoM) in the ski boot, ankle and knee joints were calculated and compared. An average RoM in the skiing boot on the side of prosthesis (4.4 ± 1.1°) was significantly lower compared to an intact leg (5.9 ± 1.8°) and the control group (6.5 ± 2.3°). In the ankle joint, the average RoM was determined to be 13.2±2.9° in the prosthesis, 12.7 ± 2.8° in an intact leg and 14.8±3.6 in the control group. However, the RoM of the knee joint in the prosthesis (42.2 ± 4.2°) was significantly larger than that of the intact leg (34.7 ± 4.4°). The average RoM of the knee joint in the control group was 47.8 ± 5.4°. The influences of additional loads on the kinematics of the lower extremities were different on the side of the prosthesis and on the intact leg. In contrast, additional loads did not produce any significant differences in the control group. Although different CoFAs in the ski boot, ankle and knee joints were used, an above-knee prosthesis with a built-in multi-axis prosthetic knee enables comparable leg kinematics in simulated alpine skiing. Key points The RoM in the ski boot on the side of the prosthetic leg was smaller than the RoM of the intact leg and the control group of healthy subjects. The RoM in the ankle joint of prosthetic leg was comparable to that of the intact leg and the control group of healthy subjects. The RoM in the prosthetic knee joint was greater than the RoM in the knee joint of the

The Tao of Microelectronics

NASA Astrophysics Data System (ADS)

Zhang, Yumin

2014-12-01

Microelectronics is a challenging course to many undergraduate students and is often described as very messy. Before taking this course, all the students have learned circuit analysis, where basically all the problems can be solved by applying Kirchhoff's laws. In addition, most engineering students have also learned engineering mechanics: statics and dynamics, where Newton's laws and related principles can be applied in solving all the problems. However, microelectronics is not as clean as these courses. There are hundreds of equations for different circuits, and it is impossible to remember which equation should be applied to which circuit. One of the common pitfalls in learning this course is over-focusing at the equation level and ignoring the ideas (Tao) behind it. Unfortunately, these ideas are not summarized and emphasized in most microelectronics textbooks, though they cover various electronic circuits comprehensively. Therefore, most undergraduate students feel at a loss when they start to learn this topic. This book tries to illustrate the major ideas and the basic analysis techniques, so that students can derive the right equations easily when facing an electronic circuit.

SphK1 inhibitor II (SKI-II) inhibits acute myelogenous leukemia cell growth in vitro and in vivo

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Li; Weng, Wei; Sun, Zhi-Xin

Previous studies have identified sphingosine kinase 1 (SphK1) as a potential drug target for treatment of acute myeloid leukemia (AML). In the current study, we investigated the potential anti-leukemic activity of a novel and specific SphK1 inhibitor, SKI-II. We demonstrated that SKI-II inhibited growth and survival of human AML cell lines (HL-60 and U937 cells). SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, andmore » concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells. Conversely, exogenously-added S1P protected against SKI-II-induced cytotoxicity, while cell permeable short-chain ceramide (C6) aggravated SKI-II's lethality against AML cells. Notably, SKI-II induced potent apoptotic death in primary human AML cells, but was generally safe to the human peripheral blood mononuclear cells (PBMCs) isolated from healthy donors. In vivo, SKI-II administration suppressed growth of U937 leukemic xenograft tumors in severe combined immunodeficient (SCID) mice. These results suggest that SKI-II might be further investigated as a promising anti-AML agent. - Highlights: • SKI-II inhibits proliferation and survival of primary and transformed AML cells. • SKI-II induces apoptotic death of AML cells, but is safe to normal PBMCs. • SKI-II is more efficient than two known SphK1 inhibitors in inhibiting AML cells. • SKI-II inhibits SphK1 activity, while increasing ceramide production in AML cells. • SKI-II dose-dependently inhibits U937 xenograft growth in SCID mice.« less

Automated classification of single airborne particles from two-dimensional angle-resolved optical scattering (TAOS) patterns by non-linear filtering

NASA Astrophysics Data System (ADS)

Crosta, Giovanni Franco; Pan, Yong-Le; Aptowicz, Kevin B.; Casati, Caterina; Pinnick, Ronald G.; Chang, Richard K.; Videen, Gorden W.

2013-12-01

Measurement of two-dimensional angle-resolved optical scattering (TAOS) patterns is an attractive technique for detecting and characterizing micron-sized airborne particles. In general, the interpretation of these patterns and the retrieval of the particle refractive index, shape or size alone, are difficult problems. By reformulating the problem in statistical learning terms, a solution is proposed herewith: rather than identifying airborne particles from their scattering patterns, TAOS patterns themselves are classified through a learning machine, where feature extraction interacts with multivariate statistical analysis. Feature extraction relies on spectrum enhancement, which includes the discrete cosine FOURIER transform and non-linear operations. Multivariate statistical analysis includes computation of the principal components and supervised training, based on the maximization of a suitable figure of merit. All algorithms have been combined together to analyze TAOS patterns, organize feature vectors, design classification experiments, carry out supervised training, assign unknown patterns to classes, and fuse information from different training and recognition experiments. The algorithms have been tested on a data set with more than 3000 TAOS patterns. The parameters that control the algorithms at different stages have been allowed to vary within suitable bounds and are optimized to some extent. Classification has been targeted at discriminating aerosolized Bacillus subtilis particles, a simulant of anthrax, from atmospheric aerosol particles and interfering particles, like diesel soot. By assuming that all training and recognition patterns come from the respective reference materials only, the most satisfactory classification result corresponds to 20% false negatives from B. subtilis particles and <11% false positives from all other aerosol particles. The most effective operations have consisted of thresholding TAOS patterns in order to reject defective ones

Case 3. "Jiang Tao v. Chengdu Branch, People's People's Bank of China": Opinion by the People's Court in Wuhou District, Chengdu, Sichuan Province

ERIC Educational Resources Information Center

Chinese Education and Society, 2006

2006-01-01

This article presents the decision of the People's Court in Wuhou District, Chengdu, Sichuan Province on the Jiang Tao v. Chengdu Branch, People's People's Bank of China case. Jiang Tao, the plaintiff, claimed that the defendant Chengdu Branch placed an announcement in the "Chengdu Business Daily" to "recruit tellers for Chengdu…

Thermal comfort of dual-chamber ski gloves

NASA Astrophysics Data System (ADS)

Dotti, F.; Colonna, M.; Ferri, A.

2017-10-01

In this work, the special design of a pair of ski gloves has been assessed in terms of thermal comfort. The glove 2in1 Gore-Tex has a dual-chamber construction, with two possible wearing configurations: one called “grip” to maximize finger flexibility and one called “warm” to maximize thermal insulation in extremely cold conditions. The dual-chamber gloves has been compared with two regular ski gloves produced by the same company. An intermittent test on a treadmill was carried out in a climatic chamber: it was made of four intense activity phases, during which the volunteer ran at 9 km/h on a 5% slope for 4 minutes, spaced out by 5-min resting phases. Finger temperature measurements were compared with the thermal sensations expressed by two volunteers during the test.

Ski represses BMP signaling in Xenopus and mammalian cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

kluo@lbl.gov

2001-05-16

The bone morphogenic proteins (BMPs) play important roles in vertebrate development. In Xenopus, BMPs act as epidermal inducers and also as negative regulators of neurogenesis. Antagonism of BMP signaling results in neuralization. BMPs signal through the cell-surface receptors and downstream Smad molecules. Upon stimulation with BMP, Smad1, Smad5, and Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocate into the nucleus, where they regulate the expression of BMP target genes. Here, we show that the Ski oncoprotein can block BMP signaling and the expression of BMP-responsive genes in both Xenopus and mammalian cells bymore » directly interacting with and repressing the activity of BMP-specific Smad complexes. This ability to antagonize BMP signaling results in neuralization by Ski in the Xenopus embryo and blocking of osteoblast differentiation of murine W-20-17 cells. Thus, Ski is able to repress the activity of all receptor-associated Smads and may regulate vertebrate development by modulating the signaling activity of transforming growth factor-{beta} family members.« less

Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive function.

PubMed

Wang, Peng; Chen, Zhen; Meng, Zhi-Qiang; Fan, Jie; Luo, Jian-Min; Liang, Wang; Lin, Jun-Hua; Zhou, Zhen-Hua; Chen, Hao; Wang, Kun; Shen, Ye-Hua; Xu, Zu-De; Liu, Lu-Ming

2009-09-01

Ski used to be defined as an oncogene that contributes to the resistance of tumor cells to transforming growth factor-beta (TGF-beta)-induced growth arrest. As TGF-beta has a dual effect on tumor growth with both tumor-suppressing and -promoting activity depending on the stage of carcinogenesis and the cell type, the precise role of Ski in carcinogenesis remains unclear. In this study, we show that downregulation of Ski through lentivirus-mediated RNA interference decreases tumor growth both in vitro and in vivo, yet promotes cell invasiveness in vitro, and lung metastasis in vivo in the pancreatic cancer cell line SW1990, which contain wild-type Smad4 expression, and the BxPC3 cell line, which is Smad4 deficient. We also show that the downregulation of Ski increases TGF-beta-induced transcriptional activity, which is associated with increased TGF-beta-dependent Smad2/3 phosphorylation, and results in an altered expression profile of TGF-beta-inducible genes involved in metastasis, angiogenesis and cell proliferation and epithelial-mesenchymal transition. Immunohistochemical analysis of specimens from 71 patients with pancreatic adenocarcinoma showed a significant association between overexpression of Ski and decreased patient survival time (P = 0.0024). Our results suggest that Ski may act as a tumor proliferation-promoting factor or as a metastatic suppressor in human pancreatic cancer.

The influence of increased distal loading on metabolic cost, efficiency, and kinematics of roller ski skating.

PubMed

Bolger, Conor M; Bessone, Veronica; Federolf, Peter; Ettema, Gertjan; Sandbakk, Øyvind

2018-01-01

The purpose of the present study was to examine the influence of increased loading of the roller ski on metabolic cost, gross efficiency, and kinematics of roller ski skating in steep and moderate terrain, while employing two incline-specific techniques. Ten nationally ranked male cross-country skiers were subjected to four 7-minute submaximal intervals, with 0, 0.5, 1.0, and 1.5 kg added beneath the roller-ski in a randomized order. This was done on two separate days, with the G2 skating at 12% incline and 7 km/h speed and G3 skating at 5% incline and 14 km/h speed, respectively. At 12% incline, there was a significant increase in metabolic rate and a decrease in gross efficiency with added weight (P<0.001 and P = 0.002). At 5% incline, no change in metabolic rate or gross efficiency was found (P = 0.89 and P = 0.11). Rating of perceived exertion (RPE) increased gradually with added weight at both inclines (P>0.05). No changes in cycle characteristics were observed between the different ski loadings at either incline, although the lateral and vertical displacements of the foot/skis were slightly altered at 12% incline with added weight. In conclusion, the present study demonstrates that increased loading of the ski increases the metabolic cost and reduces gross efficiency during steep uphill roller skiing in G2 skating, whereas no significant effect was revealed when skating on relatively flat terrain in G3. Cycle characteristics remained unchanged across conditions at both inclines, whereas small adjustments in the displacement of the foot coincided with the efficiency changes in uphill terrain. The increased RPE values with added ski-weight at both inclines indicates that other factors than those measured here could have influenced effort and/or fatigue when lifting a heavier ski.

Biomechanical pole and leg characteristics during uphill diagonal roller skiing.

PubMed

Lindinger, Stefan Josef; Göpfert, Caroline; Stöggl, Thomas; Müller, Erich; Holmberg, Hans-Christer

2009-11-01

Diagonal skiing as a major classical technique has hardly been investigated over the last two decades, although technique and racing velocities have developed substantially. The aims of the present study were to 1) analyse pole and leg kinetics and kinematics during submaximal uphill diagonal roller skiing and 2) identify biomechanical factors related to performance. Twelve elite skiers performed a time to exhaustion (performance) test on a treadmill. Joint kinematics and pole/plantar forces were recorded separately during diagonal roller skiing (9 degrees; 11 km/h). Performance was correlated to cycle length (r = 0.77; P < 0.05), relative leg swing (r = 0.71), and gliding time (r = 0.74), hip flexion range of motion (ROM) during swing (r = 0.73) and knee extension ROM during gliding (r = 0.71). Push-off demonstrated performance correlations for impulse of leg force (r = 0.84), relative duration (r= -0.76) and knee flexion (r = 0.73) and extension ROM (r = 0.74). Relative time to peak pole force was associated with performance (r = 0.73). In summary, diagonal roller skiing performance was linked to 1) longer cycle length, 2) greater impulse of force during a shorter push-off with larger flexion/extension ROMs in leg joints, 3) longer leg swing, and 4) later peak pole force, demonstrating the major key characteristics to be emphasised in training.

A simulation of cross-country skiing on varying terrain by using a mathematical power balance model

PubMed Central

Moxnes, John F; Sandbakk, Øyvind; Hausken, Kjell

2013-01-01

The current study simulated cross-country skiing on varying terrain by using a power balance model. By applying the hypothetical inductive deductive method, we compared the simulated position along the track with actual skiing on snow, and calculated the theoretical effect of friction and air drag on skiing performance. As input values in the model, air drag and friction were estimated from the literature, whereas the model included relationships between heart rate, metabolic rate, and work rate based on the treadmill roller-ski testing of an elite cross-country skier. We verified this procedure by testing four models of metabolic rate against experimental data on the treadmill. The experimental data corresponded well with the simulations, with the best fit when work rate was increased on uphill and decreased on downhill terrain. The simulations predicted that skiing time increases by 3%–4% when either friction or air drag increases by 10%. In conclusion, the power balance model was found to be a useful tool for predicting how various factors influence racing performance in cross-country skiing. PMID:24379718

A simulation of cross-country skiing on varying terrain by using a mathematical power balance model.

PubMed

Moxnes, John F; Sandbakk, Oyvind; Hausken, Kjell

2013-01-01

The current study simulated cross-country skiing on varying terrain by using a power balance model. By applying the hypothetical inductive deductive method, we compared the simulated position along the track with actual skiing on snow, and calculated the theoretical effect of friction and air drag on skiing performance. As input values in the model, air drag and friction were estimated from the literature, whereas the model included relationships between heart rate, metabolic rate, and work rate based on the treadmill roller-ski testing of an elite cross-country skier. We verified this procedure by testing four models of metabolic rate against experimental data on the treadmill. The experimental data corresponded well with the simulations, with the best fit when work rate was increased on uphill and decreased on downhill terrain. The simulations predicted that skiing time increases by 3%-4% when either friction or air drag increases by 10%. In conclusion, the power balance model was found to be a useful tool for predicting how various factors influence racing performance in cross-country skiing.

Kinematics and Kinetics of Squats, Drop Jumps and Imitation Jumps of Ski Jumpers

PubMed Central

Pauli, Carole A.; Keller, Melanie; Ammann, Fabian; Hübner, Klaus; Lindorfer, Julia; Taylor, William R.

2016-01-01

Abstract Pauli, CA, Keller, M, Ammann, F, Hübner, K, Lindorfer, J, Taylor, WR, and Lorenzetti, S. Kinematics and kinetics of squats, drop jumps and imitation jumps of ski jumpers. J Strength Cond Res 30(3): 643–652, 2016—Squats, drop jumps, and imitation jumps are commonly used training exercises in ski jumping to enhance maximum force, explosive force, and sport-specific skills. The purpose of this study was to evaluate the kinetics and kinematics of training exercises in ski jumping and to find objective parameters in training exercises that most correlate with the competition performance of ski jumpers. To this end, barbell squats, drop jumps, and imitation jumps were measured in a laboratory environment for 10 elite ski jumpers. Force and motion data were captured, and the influence of maximum vertical force, force difference, vertical take-off velocity, knee moments, knee joint power, and a knee valgus/varus index was evaluated and correlated with their season jump performance. The results indicate that, especially for the imitation jumps, a good correlation exists between the vertical take-off velocity and the personal jump performance on the hill (R = 0.718). Importantly, however, the more the athletes tended toward a valgus knee alignment during the measured movements, the worse their performance (R = 0.729 imitation jumps; R = 0.685 squats). Although an evaluation of the athletes' lower limb alignment during competitive jumping on the hill is still required, these preliminary data suggest that performance training should additionally concentrate on improving knee alignment to increase ski jumping performance. PMID:26418370

Whole-Body Vibrations Associated With Alpine Skiing: A Risk Factor for Low Back Pain?

PubMed Central

Supej, Matej; Ogrin, Jan; Holmberg, Hans-Christer

2018-01-01

Alpine skiing, both recreational and competitive, is associated with high rates of injury. Numerous studies have shown that occupational exposure to whole-body vibrations is strongly related to lower back pain and some suggest that, in particular, vibrations of lower frequencies could lead to overuse injuries of the back in connection with alpine ski racing. However, it is not yet known which forms of skiing involve stronger vibrations and whether these exceed safety thresholds set by existing standards and directives. Therefore, this study was designed to examine whole-body vibrations connected with different types of skiing and the associated potential risk of developing low back pain. Eight highly skilled ski instructors, all former competitive ski racers and equipped with five accelerometers and a Global Satellite Navigation System to measure vibrations and speed, respectively, performed six different forms of skiing: straight running, plowing, snow-plow swinging, basic swinging, short swinging, and carved turns. To estimate exposure to periodic, random and transient vibrations the power spectrum density (PSD) and standard ISO 2631-1:1997 parameters [i.e., the weighted root-mean-square acceleration (RMS), crest factor, maximum transient vibration value and the fourth-power vibration dose value (VDV)] were calculated. Ground reaction forces were estimated from data provided by accelerometers attached to the pelvis. The major novel findings were that all of the forms of skiing tested produced whole-body vibrations, with highest PSD values of 1.5–8 Hz. Intensified PSD between 8.5 and 35 Hz was observed only when skidding was involved. The RMS values for 10 min of short swinging or carved turns, as well as all 10-min equivalent VDV values exceeded the limits set by European Directive 2002/44/EC for health and safety. Thus, whole-body vibrations, particularly in connection with high ground reaction forces, contribute to a high risk for low back pain among active

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

PubMed

Singbrant, Sofie; Wall, Meaghan; Moody, Jennifer; Karlsson, Göran; Chalk, Alistair M; Liddicoat, Brian; Russell, Megan R; Walkley, Carl R; Karlsson, Stefan

2014-04-01

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a marked enhancement of myeloid differentiation at the expense of other lineages. Accordingly, enforced expression of SKI induced a gene signature associated with hematopoietic stem cells and myeloid differentiation, as well as hepatocyte growth factor signaling. Here we demonstrate that, in contrast to what has generally been assumed, the significant impact of SKI on hematopoiesis is independent of its ability to inhibit TGF-beta signaling. Instead, myeloid progenitors expressing SKI are partially dependent on functional hepatocyte growth factor signaling. Collectively our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease.

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease

PubMed Central

Singbrant, Sofie; Wall, Meaghan; Moody, Jennifer; Karlsson, Göran; Chalk, Alistair M.; Liddicoat, Brian; Russell, Megan R.; Walkley, Carl R.; Karlsson, Stefan

2014-01-01

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a marked enhancement of myeloid differentiation at the expense of other lineages. Accordingly, enforced expression of SKI induced a gene signature associated with hematopoietic stem cells and myeloid differentiation, as well as hepatocyte growth factor signaling. Here we demonstrate that, in contrast to what has generally been assumed, the significant impact of SKI on hematopoiesis is independent of its ability to inhibit TGF-beta signaling. Instead, myeloid progenitors expressing SKI are partially dependent on functional hepatocyte growth factor signaling. Collectively our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease. PMID:24415629

Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling.

PubMed

Chen, Weijun; Lam, Suvana S; Srinath, Hema; Schiffer, Celia A; Royer, William E; Lin, Kai

2007-04-13

The family of Smad proteins mediates transforming growth factor-beta (TGF-beta) signaling in cell growth and differentiation. Smads repress or activate TGF-beta signaling by interacting with corepressors (e.g. Ski) or coactivators (e.g. CREB-binding protein (CBP)), respectively. Specifically, Ski has been shown to interfere with the interaction between Smad3 and CBP. However, it is unclear whether Ski competes with CBP for binding to Smads and whether they can interact with Smad3 at the same binding surface on Smad3. We investigated the interactions among purified constructs of Smad, Ski, and CBP in vitro by size-exclusion chromatography, isothermal titration calorimetry, and mutational studies. Here, we show that Ski-(16-192) interacted directly with a homotrimer of receptor-regulated Smad protein (R-Smad), e.g. Smad2 or Smad3, to form a hexamer; Ski-(16-192) interacted with an R-Smad.Smad4 heterotrimer to form a pentamer. CBP-(1941-1992) was also found to interact directly with an R-Smad homotrimer to form a hexamer and with an R-Smad.Smad4 heterotrimer to form a pentamer. Moreover, these domains of Ski and CBP competed with each other for binding to Smad3. Our mutational studies revealed that domains of Ski and CBP interacted with Smad3 at a portion of the binding surface of the Smad anchor for receptor activation. Our results suggest that Ski negatively regulates TGF-beta signaling by replacing CBP in R-Smad complexes. Our working model suggests that Smad protein activity is delicately balanced by Ski and CBP in the TGF-beta pathway.

Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression

PubMed Central

2011-01-01

Background SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN protein levels co-exist with active autocrine TGF-β signaling in cancer cells is yet to be understood. Results In this study, we found elevated SKI and SnoN protein levels in a panel of melanoma cell lines, as compared to normal melanocytes. There was no correlation between SKI protein content and the capacity of melanoma cells to invade Matrigel™, to form subcutaneous tumors, or to metastasize to bone after intracardiac inoculation into nude mice. Nor did we find a correlation between SKI expression and histopathological staging of human melanoma. TGF-β induced a rapid and dose-dependent degradation of SKI protein, associated with SMAD3/4 specific transcriptional response and induction of pro-metastatic target genes, partially prevented by pharmacologic blockade of proteasome activity. SKI knockdown in 1205Lu melanoma cells did not alter their invasive capacity or transcriptional responses to TGF-β, and did not allow p21 expression in response to TGF-β or reveal any growth inhibitory activity of TGF-β. Conclusions Despite high expression in melanoma cells, the role of SKI in melanoma remains elusive: SKI does not efficiently interfere with the pro-oncogenic activities of TGF-β, unless stabilized by proteasome blockade. Its highly labile nature makes it an unlikely target for therapeutic intervention. PMID:21211030

An internet-based intervention for adjustment disorder (TAO): study protocol for a randomized controlled trial.

PubMed

Rachyla, Iryna; Pérez-Ara, Marian; Molés, Mar; Campos, Daniel; Mira, Adriana; Botella, Cristina; Quero, Soledad

2018-05-31

Adjustment Disorder (AjD) is a common and disabling mental health problem. The lack of research on this disorder has led to the absence of evidence-based interventions for its treatment. Moreover, because the available data indicate that a high percentage of people with mental illness are not treated, it is necessary to develop new ways to provide psychological assistance. The present study describes a Randomized Controlled Trial (RCT) aimed at assessing the effectiveness and acceptance of a linear internet-delivered cognitive-behavioral therapy (ICBT) intervention for AjD. A two-armed RCT was designed to compare an intervention group to a waiting list control group. Participants from the intervention group will receive TAO, an internet-based program for AjD composed of seven modules. TAO combines CBT and Positive Psychology strategies in order to provide patients with complete support, reducing their clinical symptoms and enhancing their capacity to overcome everyday adversity. Participants will also receive short weekly telephone support. Participants in the control group will be assessed before and after a seven-week waiting period, and then they will be offered the same intervention. Participants will be randomly assigned to one of the 2 groups. Measurements will be taken at five different moments: baseline, post-intervention, and three follow-up periods (3-, 6- and 12-month). BDI-II and BAI will be used as primary outcome measures. Secondary outcomes will be symptoms of AjD, posttraumatic growth, positive and negative affect, and quality of life. The development of ICBT programs like TAO responds to a need for evidence-based interventions that can reach most of the people who need them, reducing the burden and cost of mental disorders. More specifically, TAO targets AjD and will entail a step forward in the treatment of this prevalent but under-researched disorder. Finally, it should be noted that this is the first RCT focusing on an internet

Integrating an Intelligent Tutoring System for TAOs with Second Life

DTIC Science & Technology

2010-12-01

SL) and interacts with a number of computer -controlled objects that take on the roles of the TAO’s teammates. TAOs rely on the same mechanism to...projects that utilize both game and simulation technology for training. He joined Stottler Henke in the fall of 2000 and holds a Ph.D. in computer science...including implementing tutors in multiuser worlds. He has been at Stottler Henke since 2005 and has a MS in computer science from Stanford University

The Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Transforming Growth Factor-β Signaling by Destabilizing Ski and Inducing Smad7*

PubMed Central

Band, Arja M.; Björklund, Mia; Laiho, Marikki

2009-01-01

Ski is an oncoprotein that negatively regulates transforming growth factor (TGF)-β signaling. It acts as a transcriptional co-repressor by binding to TGF-β signaling molecules, Smads. Efficient TGF-β signaling is facilitated by rapid proteasome-mediated degradation of Ski by TGF-β. Here we report that Ski is phosphorylated by Akt/PKB kinase. Akt phosphorylates Ski on a highly conserved Akt motif at threonine 458 both in vitro and in vivo. The phosphorylation of Ski at threonine 458 is induced by Akt pathway activators including insulin, insulin-like growth factor-1, and hepatocyte growth factor. The phosphorylation of Ski causes its destabilization and reduces Ski-mediated inhibition of expression of another negative regulator of TGF-β, Smad7. Induction of Smad7 levels leads to inactivation of TGF-β receptors and TGF-β signaling cascade, as indicated by reduced induction of TGF-β target p15. Therefore, Akt modulates TGF-β signaling by temporarily adjusting the levels of two TGF-β pathway negative regulators, Ski and Smad7. These novel findings demonstrate that Akt pathway activation directly impacts TGF-β pathway. PMID:19875456

Involvement of the c-Ski oncoprotein in cell cycle arrest and transformation during nurse cell formation after Trichinella spiralis infection.

PubMed

Wu, Z; Nagano, I; Boonmars, T; Takahashi, Y

2006-09-01

The role of c-Ski, an oncoprotein encoded by the oncogene, c-ski, in Trichinella spiralis-infected muscle tissues during nurse cell formation, was investigated by following the expression kinetics and distribution of c-Ski (both protein and mRNA) in the infected muscle cell, as well as the expression kinetics of the transforming growth factor beta (TGF-beta) signaling pathway factor genes (TGF-beta, Smad2 and Smad4) which cooperate with c-Ski. Immunohistochemical analysis using an anti-c-Ski antibody indicated that in the early stages of infection (13 and 18 days post-infection (p.i.)) the increased expression of the c-Ski protein was limited to the eosinophilic cytoplasm and not the enlarged nuclei or basophilic cytoplasm. At a later stage of infection (23 and 28 days p.i.) the c-Ski protein was limited to the enlarged nuclei in the basophilic cytoplasm, rather than the eosinophilic cytoplasm. At 48 days p.i., the c-Ski protein was barely detectable. Real-time PCR analysis showed that expression of the c-ski gene increased from 13 days p.i., reached a peak at 23-28 days p.i. and then decreased to a low level by 48 days p.i. Expression kinetics for the TGF-beta signaling pathway factor genes (TGF-beta, Smad2 and Smad4) were similar to that of c-ski. These findings provide evidence that the c-Ski protein is involved in nurse cell formation through the TGF-beta signaling pathway process in the host cell nucleus.

A systematic video analysis of 69 injury cases in World Cup alpine skiing.

PubMed

Bere, T; Flørenes, T W; Krosshaug, T; Haugen, P; Svandal, I; Nordsletten, L; Bahr, R

2014-08-01

We have limited insight into how injuries occur in professional ski racing. The aim of this study was to describe the injury situations in World Cup alpine skiing. Injuries reported through the International Ski Federation Injury Surveillance System for three consecutive World Cup seasons (2006-2009) were obtained on video. In total, 69 injuries and 124 runs of matched controls were analysed by five experts to evaluate the skiing situation, skier behavior, as well as piste-related factors. A chi-square test (95% CI, P ≤ 0.05) was used to examine whether there was a difference between course sections regarding where the injury situation occurred. The skier was most frequently turning (n = 55) or landing from a jump (n = 13) at the time of injury. Most of the injuries to the head and upper body (96%) resulted from crashes, while the majority of knee injuries (83%) occurred while the skier was still skiing. Gate contact contributed to 30% of the injuries, while 9% occurred at contact with safety nets/material. Almost half of the injuries (46%) occurred in the final fourth of the course. A particular concern was the high contribution of inappropriate gate contact and the high-energy impacts to the body when crashing. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.

PubMed

Marcelain, Katherine; Armisen, Ricardo; Aguirre, Adam; Ueki, Nobuhide; Toro, Jessica; Colmenares, Clemencia; Hayman, Michael J

2012-01-01

Ski is a transcriptional regulator that has been considered an oncoprotein given its ability to induce oncogenic transformation in avian model systems. However, studies in mouse and in some human tumor cells have also indicated a tumor suppressor activity for this protein. We found that Ski-/- mouse embryo fibroblasts exhibit high levels of genome instability, namely aneuploidy, consistent with a tumor suppressor function for Ski. Time-lapse microscopy revealed lagging chromosomes and chromatin/chromosome bridges as the major cause of micronuclei (MN) formation and the subsequent aneuploidy. Although these cells arrested in mitosis after treatment with spindle disrupting drugs and exhibited a delayed metaphase/anaphase transition, spindle assembly checkpoint (SAC) was not sufficient to prevent chromosome missegregation, consistent with a weakened SAC. Our in vivo analysis also showed dynamic metaphase plate rearrangements with switches in polarity in cells arrested in metaphase. Importantly, after ectopic expression of Ski the cells that displayed this metaphase arrest died directly during metaphase or after aberrant cell division, relating SAC activation and mitotic cell death. This increased susceptibility to undergo mitosis-associated cell death reduced the number of MN-containing cells. The presented data support a new role for Ski in the mitotic process and in maintenance of genetic stability, providing insights into the mechanism of tumor suppression mediated by this protein. Copyright © 2011 Wiley Periodicals, Inc.

Kinematics and Kinetics of Squats, Drop Jumps and Imitation Jumps of Ski Jumpers.

PubMed

Pauli, Carole A; Keller, Melanie; Ammann, Fabian; Hübner, Klaus; Lindorfer, Julia; Taylor, William R; Lorenzetti, Silvio

2016-03-01

Squats, drop jumps, and imitation jumps are commonly used training exercises in ski jumping to enhance maximum force, explosive force, and sport-specific skills. The purpose of this study was to evaluate the kinetics and kinematics of training exercises in ski jumping and to find objective parameters in training exercises that most correlate with the competition performance of ski jumpers. To this end, barbell squats, drop jumps, and imitation jumps were measured in a laboratory environment for 10 elite ski jumpers. Force and motion data were captured, and the influence of maximum vertical force, force difference, vertical take-off velocity, knee moments, knee joint power, and a knee valgus/varus index was evaluated and correlated with their season jump performance. The results indicate that, especially for the imitation jumps, a good correlation exists between the vertical take-off velocity and the personal jump performance on the hill (R = 0.718). Importantly, however, the more the athletes tended toward a valgus knee alignment during the measured movements, the worse their performance (R = 0.729 imitation jumps; R = 0.685 squats). Although an evaluation of the athletes' lower limb alignment during competitive jumping on the hill is still required, these preliminary data suggest that performance training should additionally concentrate on improving knee alignment to increase ski jumping performance.

a Study on Mental Representations for Realistic Visualization the Particular Case of Ski Trail Mapping

NASA Astrophysics Data System (ADS)

Balzarini, R.; Dalmasso, A.; Murat, M.

2015-08-01

This article presents preliminary results from a research project in progress that brings together geographers, cognitive scientists, historians and computer scientists. The project investigates the evolution of a particular territorial model: ski trails maps. Ski resorts, tourist and sporting innovations for mountain economies since the 1930s, have needed cartographic representations corresponding to new practices of the space.Painter artists have been involved in producing ski maps with painting techniques and panoramic views, which are by far the most common type of map, because they allow the resorts to look impressive to potential visitors. These techniques have evolved throughout the mutations of the ski resorts. Paper ski maps no longer meet the needs of a large part of the customers; the question now arises of their adaptation to digital media. In a computerized process perspective, the early stage of the project aims to identify the artist-representations, based on conceptual and technical rules, which are handled by users-skiers to perform a task (location, wayfinding, decision-making) and can be transferred to a computer system. This article presents the experimental phase that analyzes artist and user mental representations that are at stake during the making and the reading of a paper ski map. It particularly focuses on how the invention of the artist influences map reading.

Does listening to music with an audio ski helmet impair reaction time to peripheral stimuli?

PubMed

Ruedl, G; Pocecco, E; Wolf, M; Schöpf, S; Burtscher, M; Kopp, M

2012-12-01

With the recent worldwide increase in ski helmet use, new market trends are developing, including audio helmets for listening to music while skiing or snowboarding. The aim of this study was to evaluate whether listening to music with an audio ski helmet impairs reaction time to peripheral stimuli. A within-subjects design study using the Compensatory-Tracking-Test was performed on 65 subjects (36 males and 29 females) who had a mean age of 23.3 ± 3.9 years. Using repeated measures analysis of variance, we found significant differences in reaction times between the 4 test conditions (p=0.039). The lowest mean reaction time (± SE) was measured for helmet use while listening to music (507.9 ± 13.2 ms), which was not different from helmet use alone (514.6 ± 12.5 ms) (p=0.528). However, compared to helmet use while listening to music, reaction time was significantly longer for helmet and ski goggles used together (535.8 ± 14.2 ms, p=0.005), with a similar trend for helmet and ski goggles used together while listening to music (526.9 ± 13.8 ms) (p=0.094). In conclusion, listening to music with an audio ski helmet did not increase mean reaction time to peripheral stimuli in a laboratory setting. © Georg Thieme Verlag KG Stuttgart · New York.

Take-off analysis of the Olympic ski jumping competition (HS-106m).

PubMed

Virmavirta, Mikko; Isolehto, Juha; Komi, Paavo; Schwameder, Hermann; Pigozzi, Fabio; Massazza, Giuseppe

2009-05-29

The take-off phase (approximately 6m) of the jumps of all athletes participating in the individual HS-106m hill ski jumping competition at the Torino Olympics was filmed with two high-speed cameras. The high altitude of the Pragelato ski jumping venue (1600m) and slight tail wind in the final jumping round were expected to affect the results of this competition. The most significant correlation with the length of the jump was found in the in-run velocity (r=0.628, p<0.001, n=50). This was a surprise in Olympic level ski jumping, and suggests that good jumpers simply had smaller friction between their skis and the in-run tracks and/or the aerodynamic quality of their in-run position was better. Angular velocity of the hip joint of the best jumpers was also correlated with jumping distance (r=0.651, p<0.05, n=10). The best jumpers in this competition exhibited very different take-off techniques, but still they jumped approximately the same distance. This certainly improves the interests in ski jumping among athletes and spectators. The comparison between the take-off techniques of the best jumpers showed that even though the more marked upper body movement creates higher air resistance, it does not necessarily result in shorter jumping distance if the exposure time to high air resistance is not too long. A comparison between the first and second round jumps of the same jumpers showed that the final results in this competition were at least partly affected by the wind conditions.

[Role of Ski/SnoN protein in the regulation of TGF-beta signal pathway].

PubMed

Lu, Zhao-hui; Chen, Jie

2003-04-01

TGF-beta signal pathway plays an important role in the cell growth, differentiation, formation of extracellular matrix, embryo development and carcinogenesis, etc. However, the regulation of TGF-beta pathway is not totally understood. In 1999, three independent research groups found that Ski/SnoN protein could inhibit the TGF-beta mediated transcription by recruiting N-CoR, a transcription co-repressor. Later studies suggested that TGF-beta and SMADs degraded the Ski/SnoN protein by mediating ubiquitin linkage, showing negative feedback regulation. The important findings in Ski/SnoN laid the theoretical foundation for demonstrating the function of TGF-beta signal pathway.

Three-Dimensional Lower Extremity Joint Loading in a Carved Ski and Snowboard Turn: A Pilot Study

PubMed Central

Müller, Erich

2014-01-01

A large number of injuries to the lower extremity occur in skiing and snowboarding. Due to the difficulty of collecting 3D kinematic and kinetic data with high accuracy, a possible relationship between injury statistic and joint loading has not been studied. Therefore, the purpose of the current study was to compare ankle and knee joint loading at the steering leg between carved ski and snowboard turns. Kinetic data were collected using mobile force plates mounted under the toe and heel part of the binding on skies or snowboard (KISTLER). Kinematic data were collected with five synchronized, panning, tilting, and zooming cameras. An extended version of the Yeadon model was applied to calculate inertial properties of the segments. Ankle and knee joint forces and moments were calculated using inverse dynamic analysis. Results showed higher forces along the longitudinal axis in skiing and similar forces for skiing and snowboarding in anterior-posterior and mediolateral direction. Joint moments were consistently greater during a snowboard turn, but more fluctuations were observed in skiing. Hence, when comparing joint loading between carved ski and snowboard turns, one should differentiate between forces and moments, including the direction of forces and moments and the turn phase. PMID:25317202

Economic Impacts of Climate Change on Winter Tourism: Challenges for Ski Area Operators

NASA Astrophysics Data System (ADS)

Damm, A.; Köberl, J.; Prettenthaler, F.; Töglhofer, C.

2012-04-01

Increasing temperatures and snow scarce winter seasons pose a big challenge for the winter tourism industry. Changing natural snow reliability influences tourism demand and ski area operators are faced with an enhanced need of technical snow production. The goal of the present research work is to analyze the economic effects of technical snow production under future climate conditions. Snowmaking as an adaptation strategy to climate change impacts on the ski tourism industry is already taken into consideration in several studies from a scientific perspective concerning snowmaking potentials under future climate conditions and the impacts on ski season length (e.g. Scott et al. 2003; Scott & McBoyle 2007; Hennessy et al. 2008; Steiger 2010). A few studies considered economic aspects of technical snowmaking (e.g. Teich et al. 2007; Gonseth 2008). However, a detailed analysis of the costs and benefits of snowmaking under future climate and snow conditions based on sophisticated climate and snow models has not been carried out yet. The present study addresses the gap of knowledge concerning the economic profitability of prospective snowmaking requirements under future climate scenarios. We carry out a detailed cost-revenue analysis of snowmaking under current and future climate conditions for a case study site in Styria (Austria) using dynamic investment models. The starting point of all economic calculations is the daily demand for artificial snow that determines the requirements for additional snowmaking investments and additional operating costs. The demand for artificial snow is delivered by the snow cover model AMUNDSEN (see Strasser et al. 2011) and is driven by four climate scenarios. Apart from future climate conditions the profitability of snowmaking depends on changes in costs and visitor numbers. The results of a ski tourism demand model analyzing daily visitor numbers and their dependencies of prevailing weather conditions enter the cost-revenue analysis of

A survey of Canadian Alpine ski racing coaches regarding spinal protective devices for their athletes

PubMed Central

Stainsby, Brynne; Law, Jeremy; Mackinnon, Amy

2014-01-01

Introduction: Spinal protective devices are a recent addition to the protective equipment worn by competitive and recreational alpine skiers and snowboarders. Their rate of use is not documented at the time of publication. The objective of this study was to examine the current attitudes and recommendations of Canadian alpine ski racing coaches towards spinal protective devices. Methods: A convenience sample of alpine ski racing coaches across Canada were contacted in each provincial sport governing body in the ski racing community. A ten question online survey was attached to the initial email. Descriptive statistical analysis was utilized. Results: A total of 29 Canadian alpine ski racing coaches completed the study survey. All participants were familiar with spinal protective devices and 51.7% of respondents reported that they do not actively enforce spinal protective device use with their ski racing athletes. 80% of respondents reported that their Canadian ski racing club did not have guidelines or policies regarding spinal protective device use. 86.2% of respondents were unaware if their provincial sport organization had a policy regarding their use. Discussion: The majority of coaches reporting training athletes aged 10–15, which may help to explain why only half of those surveyed enforce the use of spinal protective devices. This group of athletes may not participate in speed events as frequently as older athletes, where the use of spinal protective devices is more common. Conclusion: The majority of Canadian Alpine ski coaches report a belief that spinal protective device use is important, however, far fewer enforce their use, or work in an environment with a policy requiring it. Further research is required to determine the differences in beliefs and practice. PMID:25550668

Higher Education and Happiness: The Perspectives of the Bible and Tao Te Ching

ERIC Educational Resources Information Center

Lee, Jeong-Kyu

2017-01-01

The purpose of this paper is to discuss the concepts and principles of happiness shown in the Bible and Tao Te Ching for implications in higher education. To review the paper systematically, three research questions are addressed. First, what are happiness concepts and principles in the Bible? Second, what are happiness concepts and principles in…

The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins.

PubMed

He, Jun; Tegen, Sarah B; Krawitz, Ariel R; Martin, G Steven; Luo, Kunxin

2003-08-15

The regulation of cell growth and differentiation by transforming growth factor-beta (TGF-beta) is mediated by the Smad proteins. In the nucleus, the Smad proteins are negatively regulated by two closely related nuclear proto-oncoproteins, Ski and SnoN. When overexpressed, Ski and SnoN induce oncogenic transformation of chicken embryo fibroblasts. However, the mechanism of transformation by Ski and SnoN has not been defined. We have previously reported that Ski and SnoN interact directly with Smad2, Smad3, and Smad4 and repress their ability to activate TGF-beta target genes through multiple mechanisms. Because Smad proteins are tumor suppressors, we hypothesized that the ability of Ski and SnoN to inactivate Smad function may be responsible for their transforming activity. Here, we show that the receptor regulated Smad proteins (Smad2 and Smad3) and common mediator Smad (Smad4) bind to different regions in Ski and SnoN. Mutation of both regions, but not each region alone, markedly impaired the ability of Ski and SnoN to repress TGF-beta-induced transcriptional activation and cell cycle arrest. Moreover, when expressed in chicken embryo fibroblasts, mutant Ski or SnoN defective in binding to the Smad proteins failed to induce oncogenic transformation. These results suggest that the ability of Ski and SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity. This may account for the resistance to TGF-beta-induced growth arrest in some human cancer cell lines that express high levels of Ski or SnoN.

Modelling technical snow production for skiing areas in the Austrian Alps with the physically based snow model AMUNDSEN

NASA Astrophysics Data System (ADS)

Hanzer, F.; Marke, T.; Steiger, R.; Strasser, U.

2012-04-01

Tourism and particularly winter tourism is a key factor for the Austrian economy. Judging from currently available climate simulations, the Austrian Alps show a particularly high vulnerability to climatic changes. To reduce the exposure of ski areas towards changes in natural snow conditions as well as to generally enhance snow conditions at skiing sites, technical snowmaking is widely utilized across Austrian ski areas. While such measures result in better snow conditions at the skiing sites and are important for the local skiing industry, its economic efficiency has also to be taken into account. The current work emerges from the project CC-Snow II, where improved future climate scenario simulations are used to determine future natural and artificial snow conditions and their effects on tourism and economy in the Austrian Alps. In a first step, a simple technical snowmaking approach is incorporated into the process based snow model AMUNDSEN, which operates at a spatial resolution of 10-50 m and a temporal resolution of 1-3 hours. Locations of skiing slopes within a ski area in Styria, Austria, were digitized and imported into the model environment. During a predefined time frame in the beginning of the ski season, the model produces a maximum possible amount of technical snow and distributes the associated snow on the slopes, whereas afterwards, until to the end of the ski season, the model tries to maintain a certain snow depth threshold value on the slopes. Due to only few required input parameters, this approach is easily transferable to other ski areas. In our poster contribution, we present first results of this snowmaking approach and give an overview of the data and methodology applied. In a further step in CC-Snow, this simple bulk approach will be extended to consider actual snow cannon locations and technical specifications, which will allow a more detailed description of technical snow production as well as cannon-based recordings of water and energy

Visual Resource Analysis for Solar Energy Zones in the San Luis Valley

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sullivan, Robert; Abplanalp, Jennifer M.; Zvolanek, Emily

This report summarizes the results of a study conducted by Argonne National Laboratory’s (Argonne’s) Environmental Science Division for the U.S. Department of the Interior Bureau of Land Management (BLM). The study analyzed the regional effects of potential visual impacts of solar energy development on three BLM-designated solar energy zones (SEZs) in the San Luis Valley (SLV) in Colorado, and, based on the analysis, made recommendations for or against regional compensatory mitigation to compensate residents and other stakeholders for the potential visual impacts to the SEZs. The analysis was conducted as part of the solar regional mitigation strategy (SRMS) task conductedmore » by BLM Colorado with assistance from Argonne. Two separate analyses were performed. The first analysis, referred to as the VSA Analysis, analyzed the potential visual impacts of solar energy development in the SEZs on nearby visually sensitive areas (VSAs), and, based on the impact analyses, made recommendations for or against regional compensatory mitigation. VSAs are locations for which some type of visual sensitivity has been identified, either because the location is an area of high scenic value or because it is a location from which people view the surrounding landscape and attach some level of importance or sensitivity to what is seen from the location. The VSA analysis included both BLM-administered lands in Colorado and in the Taos FO in New Mexico. The second analysis, referred to as the SEZ Analysis, used BLM visual resource inventory (VRI) and other data on visual resources in the former Saguache and La Jara Field Offices (FOs), now contained within the San Luis Valley FO (SLFO), to determine whether the changes in scenic values that would result from the development of utility-scale solar energy facilities in the SEZs would affect the quality and quantity of valued scenic resources in the SLV region as a whole. If the regional effects were judged to be significant

Comprehensive outreach, prevention education, and skin cancer screening for Utah ski resorts.

PubMed

Varedi, Amir; Secrest, Aaron M; Harding, Garrett; Maness, Lori; Branson, Donna; Smith, Kristi; Hull, Christopher M

2018-02-15

Outdoor recreation can lead to substantial sun exposure. Employees of outdoor recreation establishments with extended time outdoors have amplified cumulative exposure to ultraviolet (UV) radiation and an increased risk of skin cancer. The "Sun Safe on the Slopes" program was created by Huntsman Cancer Institute at the University of Utah and the Utah Cancer Action Network to address increased UV exposure and skin cancer risk with free skin cancer screenings, outreach, and prevention education to local ski resorts. Herein, we describe the processes and barriers to implementation of a ski resort skin screening and education program and our 5-year report of the experience and screening data. Nine free skin cancer screenings were held at Utah ski resorts between 2011 and 2016, resulting in the presumptive diagnosis of 38 skin cancers (9.6%) in 394 participants. Behavioral data collected from participants indicates suboptimal sun safety practices, including underuse of sunscreen and protective clothing. Ski resort employees who experience sun exposure during peak hours at high altitudes and UV reflection from the snow are at an increased risk of skin cancer. These data indicate a need for emphasis on sun safety education and screening and can serve as a model for future endeavors.

Biomechanical and energetic determinants of technique selection in classical cross-country skiing.

PubMed

Pellegrini, Barbara; Zoppirolli, Chiara; Bortolan, Lorenzo; Holmberg, Hans-Christer; Zamparo, Paola; Schena, Federico

2013-12-01

Classical cross-country skiing can be performed using three main techniques: diagonal stride (DS), double poling (DP), and double poling with kick (DK). Similar to other forms of human and animal gait, it is currently unclear whether technique selection occurs to minimize metabolic cost or to keep some mechanical factors below a given threshold. The aim of this study was to find the determinants of technique selection. Ten male athletes roller skied on a treadmill at different slopes (from 0° to 7° at 10km/h) and speeds (from 6 to 18km/h at 2°). The technique preferred by skiers was gathered for every proposed condition. Biomechanical parameters and metabolic cost were then measured for each condition and technique. Skiers preferred DP for skiing on the flat and they transitioned to DK and then to DS with increasing slope steepness, when increasing speed all skiers preferred DP. Data suggested that selections mainly occur to remain below a threshold of poling force. Second, critically low values of leg thrust time may limit the use of leg-based techniques at high speeds. A small role has been identified for the metabolic cost of locomotion, which determined the selection of DP for flat skiing. Copyright © 2013 Elsevier B.V. All rights reserved.

Projected climate change impacts on skiing and snowmobiling: A case study of the United States

EPA Science Inventory

A physically-based water and energy balance model is used to simulate natural snow accumulation at 247 winter recreation locations across the continental United States. We combine this model with projections of snowmaking conditions to determine downhill skiing, cross-country ski...

Sidecut radius and the mechanics of turning—equipment designed to reduce risk of severe traumatic knee injuries in alpine giant slalom ski racing

PubMed Central

Spörri, Jörg; Kröll, Josef; Gilgien, Matthias; Müller, Erich

2016-01-01

Background There is limited empirical knowledge about the effect of ski geometry, particularly in the context of injury prevention in alpine ski racing. We investigated the effect of sidecut radius on biomechanical variables related to the mechanics of turning. Methods During a field experiment, six European Cup level athletes skied on three different pairs of giant slalom (GS) skis varying in sidecut radii (30 m, 35 m and 40 m). Using a video-based three-dimensional (3D) kinematic system, a 22-point body segment model of the athletes was reconstructed in 3D, and the variables ground reaction force, centre of mass (COM) speed, COM turn radius, ski turn radius, edge angle, fore/aft position and skid angle were calculated. Results While steering out of the fall line after gate passage, ground reaction force significantly differed between the 30 m and 40 m skis and between the 35 m and 40 m skis. These differences were mainly explainable by larger COM turn radii when skiing on the 40 m ski. During the same turn phase, significant differences in ski turn radius also were found, but there were no differences in edge angle, fore/aft position and skid angle. Summary The sidecut-induced reduction in ground reaction force and the sidecut-induced increase in centre of mass and ski turn radius observed in this study provides indirect evidence of reduced self-steering of the ski. Self-steering plays a central role in the mechanism of anterior cruciate ligament rupture in alpine ski racing. PMID:26702014

A simulation model for forecasting downhill ski participation

Treesearch

Daniel J. Stynes; Daniel M. Spotts

1980-01-01

The purpose of this paper is to describe progress in the development of a general computer simulation model to forecast future levels of outdoor recreation participation. The model is applied and tested for downhill skiing in Michigan.

Involvement of c-Ski oncoprotein in carcinogenesis of cholangiocacinoma induced by Opisthorchis viverrini and N-nitrosodimethylamine.

PubMed

Boonmars, Thidarut; Wu, Zhiliang; Boonjaruspinyo, Sirintip; Puapairoj, Anucha; Kaewsamut, Butsara; Nagano, Isao; Pinlaor, Somchai; Yongvanit, Puangrat; Wonkchalee, Orasa; Juasook, Amornrat; Sudsarn, Pakkayanee; Srisawangwong, Tuanchai

2011-06-01

Opisthorchiasis is the major public health problem in the endemic areas of Thailand and Laos because Opisthorchis viverrini infection causes serious hepatobiliary diseases including CCA. The molecular mechanism of the CCA carcinogenesis induced by the infection remains obscure. To reveal the potential genes and signaling pathways to involve in the carcinogenesis, the present study investigated the expression of c-Ski, an oncogene, and two TGF-β signaling pathway relative genes, TGF-β and Smad4, during the development of CCA induced by O. viverrini infection in hamster model, and in human opisthorchiasis associated CCA. The results showed that the expression of c-Ski gene was greatly up-regulated during the carcinogenesis of CCA in hamster model. The overexpression of c-Ski was confirmed by immunohistological staining result which showed the increased expression of c-Ski protein in cytoplasm of the epithelial lining of hepatic bile ducts. Moreover, the immunohistological staining of the specimens of human opisthorchiasis associated CCA revealed the up-regulated expression of c-Ski and Smad4 proteins in the cytoplasm of the epithelial lining of hepatic bile ducts and stomal fibrosis respectively. The expression of TGF-β and Smad4 were up-regulated, which expression kinetics was time-dependent of CCA development. These results suggest that c-Ski is likely involved in the carcinogenesis of CCA induced by O. viverrini infection through regulating TGF-β signaling pathway.

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

PubMed Central

Xu, Weidong; Angelis, Konstantina; Danielpour, David; Haddad, Maher M.; Bischof, Oliver; Campisi, Judith; Stavnezer, Ed; Medrano, Estela E.

2000-01-01

The c-ski protooncogene encodes a transcription factor that binds DNA only in association with other proteins. To identify co-binding proteins, we performed a yeast two-hybrid screen. The results of the screen and subsequent co-immunoprecipitation studies identified Smad2 and Smad3, two transcriptional activators that mediate the type β transforming growth factor (TGF-β) response, as Ski-interacting proteins. In Ski-transformed cells, all of the Ski protein was found in Smad3-containing complexes that accumulated in the nucleus in the absence of added TGF-β. DNA binding assays showed that Ski, Smad2, Smad3, and Smad4 form a complex with the Smad/Ski binding element GTCTAGAC (SBE). Ski repressed TGF-β-induced expression of 3TP-Lux, the natural plasminogen activator inhibitor 1 promoter and of reporter genes driven by the SBE and the related CAGA element. In addition, Ski repressed a TGF-β-inducible promoter containing AP-1 (TRE) elements activated by a combination of Smads, Fos, and/or Jun proteins. Ski also repressed synergistic activation of promoters by combinations of Smad proteins but failed to repress in the absence of Smad4. Thus, Ski acts in opposition to TGF-β-induced transcriptional activation by functioning as a Smad-dependent co-repressor. The biological relevance of this transcriptional repression was established by showing that overexpression of Ski abolished TGF-β-mediated growth inhibition in a prostate-derived epithelial cell line. PMID:10811875

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor.

PubMed

Xu, W; Angelis, K; Danielpour, D; Haddad, M M; Bischof, O; Campisi, J; Stavnezer, E; Medrano, E E

2000-05-23

The c-ski protooncogene encodes a transcription factor that binds DNA only in association with other proteins. To identify co-binding proteins, we performed a yeast two-hybrid screen. The results of the screen and subsequent co-immunoprecipitation studies identified Smad2 and Smad3, two transcriptional activators that mediate the type beta transforming growth factor (TGF-beta) response, as Ski-interacting proteins. In Ski-transformed cells, all of the Ski protein was found in Smad3-containing complexes that accumulated in the nucleus in the absence of added TGF-beta. DNA binding assays showed that Ski, Smad2, Smad3, and Smad4 form a complex with the Smad/Ski binding element GTCTAGAC (SBE). Ski repressed TGF-beta-induced expression of 3TP-Lux, the natural plasminogen activator inhibitor 1 promoter and of reporter genes driven by the SBE and the related CAGA element. In addition, Ski repressed a TGF-beta-inducible promoter containing AP-1 (TRE) elements activated by a combination of Smads, Fos, and/or Jun proteins. Ski also repressed synergistic activation of promoters by combinations of Smad proteins but failed to repress in the absence of Smad4. Thus, Ski acts in opposition to TGF-beta-induced transcriptional activation by functioning as a Smad-dependent co-repressor. The biological relevance of this transcriptional repression was established by showing that overexpression of Ski abolished TGF-beta-mediated growth inhibition in a prostate-derived epithelial cell line.

Migration, Knowledge Transfer, and the Emergence of Australian Post-War Skiing: The Story of Charles William Anton

PubMed Central

Strobl, Philipp

2016-01-01

Abstract Skiing underwent substantial changes during the post-war years when the sport turned into a multi-billion dollar industry and a leisure activity for the masses. Despite its global nature and popularity, skiing in academic writing has not gained much recognition. This paper explores the role of knowledge transfer during the pioneering phase of post-war skiing in Australia. It describes the life of Charles William Anton, an Austrian refugee from the Anschluss who migrated to Sydney and subsequently became one of the founding fathers of Australian post-war skiing. The following pages show the multi-layered nature of skiing as a global sport by exemplifying how ideas spread from pre-war Europe to post-war Australia. The paper will also provide a case study about refugee knowledge transfer and the ‘productive process of absorption, adoption or rejection of knowledge’ that takes place once an idea has been introduced into a new environment. PMID:29170603

Migration, Knowledge Transfer, and the Emergence of Australian Post-War Skiing: The Story of Charles William Anton.

PubMed

Strobl, Philipp

2016-11-01

Skiing underwent substantial changes during the post-war years when the sport turned into a multi-billion dollar industry and a leisure activity for the masses. Despite its global nature and popularity, skiing in academic writing has not gained much recognition. This paper explores the role of knowledge transfer during the pioneering phase of post-war skiing in Australia. It describes the life of Charles William Anton, an Austrian refugee from the Anschluss who migrated to Sydney and subsequently became one of the founding fathers of Australian post-war skiing. The following pages show the multi-layered nature of skiing as a global sport by exemplifying how ideas spread from pre-war Europe to post-war Australia. The paper will also provide a case study about refugee knowledge transfer and the 'productive process of absorption, adoption or rejection of knowledge' that takes place once an idea has been introduced into a new environment.

ENERGY MANAGEMENT INNOVATION IN THE US SKI INDUSTRY

EPA Science Inventory

Ski areas represent a unique opportunity to develop innovative energy management practices in an industrial setting. Through a unique synergy of onsite generation, preferably by renewable sources and innovative technologies, and the energy storage potential of exis...

Soil nitrogen dynamics in high-altitude ski runs during the winter season (Monterosaski - Vallée d

NASA Astrophysics Data System (ADS)

Freppaz, M.; Icardi, M.; Filippa, G.; Zanini, E.

2009-04-01

In many Alpine catchments, the development of winter tourism determined a widespread change in land use, shifting from forested and cultivated lands to ski slopes. The construction of a ski slope implies a strong impact on the landscape, with potential consequences on the soil quality. In most cases, the construction procedures include the total or partial removal of the soil body, the reallocation of the fine hearth fraction, the subsequent seeding of plants and the use of organic fertilizers. This work aims to evaluate soil physical and chemical properties and nitrogen (N) dynamics in anthropogenic soils from ski slopes of different age. Study sites were located in Champoluc (AO)- NW Italy between 2400 and 2700 m ASL. Topsoils (0-10 cm depth) were sampled in 4 ski slopes hydroseeded with commercial mixtures 4, 6, 10 and 12 years earlier, and in 4 control plots at the same exposure and altitude as the ski slopes. Soil samples were characterized, N dynamics in winter was evaluated with the buried bag technique and snowpack was analyzed for chemical and physical properties. Total nitrogen (TN) content in topsoil ranged 0.75-1.06 g kg-1 and was not correlated with the ski slope age. In all but one site, the TN content was significantly lower in the ski slope than in the control plot. A positive net ammonification and nitrification throughout the winter were found in all but one ski runs. These results suggest a high variability in the evolution degree of these anthropogenic soils. The net overwinter N mineralization that we report demonstrates that these soils are biologically active during the winter season. Such activity results in a pool of labile inorganic nitrogen potentially available for plant demand at the spring snowmelt.

c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.

PubMed

Kiyono, Kunihiko; Suzuki, Hiroshi I; Morishita, Yasuyuki; Komuro, Akiyoshi; Iwata, Caname; Yashiro, Masakazu; Hirakawa, Kosei; Kano, Mitsunobu R; Miyazono, Kohei

2009-10-01

c-Ski, originally identified as a proto-oncogene product, is an important negative regulator of transforming growth factor (TGF)-beta family signaling through interaction with Smad2, Smad3, and Smad4. High expression of c-Ski has been found in some cancers, including gastric cancer. We previously showed that disruption of TGF-beta signaling by dominant-negative TGF-beta type II receptor in a diffuse-type gastric carcinoma model accelerated tumor growth through induction of tumor angiogenesis by decreased expression of the anti-angiogenic factor thrombospondin (TSP)-1. Here, we examined the function of c-Ski in human diffuse-type gastric carcinoma OCUM-2MLN cells. Overexpression of c-Ski inhibited TGF-beta signaling in OCUM-2MLN cells. Interestingly, c-Ski overexpression resulted in extensive acceleration of the growth of subcutaneous xenografts in BALB/c nu/nu female mice (6 weeks of age). Similar to tumors expressing dominant-negative TGF-beta type II receptor, histochemical studies revealed less fibrosis and increased angiogenesis in xenografted tumors expressing c-Ski compared to control tumors. Induction of TSP-1 mRNA by TGF-beta was attenuated by c-Ski in vitro, and expression of TSP-1 mRNA was decreased in tumors expressing c-Ski in vivo. These findings suggest that c-Ski overexpression promotes the growth of diffuse-type gastric carcinoma through induction of angiogenesis.

Impact of the initial classic section during a simulated cross-country skiing skiathlon on the cardiopulmonary responses during the subsequent period of skate skiing.

PubMed

Mourot, Laurent; Fabre, Nicolas; Andersson, Erik; Willis, Sarah J; Hébert-Losier, Kim; Holmberg, Hans-Christer

2014-08-01

The aim of this study was to assess potential changes in the performance and cardiorespiratory responses of elite cross-country skiers following transition from the classic (CL) to the skating (SK) technique during a simulated skiathlon. Eight elite male skiers performed two 6 km (2 × 3 km) roller-skiing time trials on a treadmill at racing speed: one starting with the classic and switching to the skating technique (CL1-SK2) and another employing the skating technique throughout (SK1-SK2), with continuous monitoring of gas exchanges, heart rates, and kinematics (video). The overall performance times in the CL1-SK2 (21:12 ± 1:24) and SK1-SK2 (20:48 ± 2:00) trials were similar, and during the second section of each performance times and overall cardiopulmonary responses were also comparable. However, in comparison with SK1-SK2, the CL1-SK2 trial involved significantly higher increases in minute ventilation (V̇E, 89.8 ± 26.8 vs. 106.8 ± 17.6 L·min(-1)) and oxygen uptake (V̇O2; 3.1 ± 0.8 vs 3.5 ± 0.5 L·min(-1)) 2 min after the transition as well as longer time constants for V̇E, V̇O2, and heart rate during the first 3 min after the transition. This higher cardiopulmonary exertion was associated with ∼3% faster cycle rates. In conclusion, overall performance during the 2 time trials did not differ. The similar performance times during the second sections were achieved with comparable mean cardiopulmonary responses. However, the observation that during the initial 3-min post-transition following classic skiing cardiopulmonary responses and cycle rates were slightly higher supports the conclusion that an initial section of classic skiing exerts an impact on performance during a subsequent section of skate skiing.

The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor.

PubMed

Ferrand, Nathalie; Atfi, Azeddine; Prunier, Céline

2010-11-01

The oncoprotein c-Ski has been implicated in the negative regulation of transforming growth factor-β (TGF-β) signaling owing to its ability to repress Smad transcriptional activity via recruitment of a transcriptional corepressor complex containing histone deacetylases. However, c-Ski has also been shown to localize to the cytoplasm, raising the interesting possibility that it might disable TGF-β signaling through alternative mechanisms. Here, we provide evidence that c-Ski can restrict TGF-β signaling by interacting directly with the activated TGF-β type I receptor (TβRI). We explored the physiologic relevance of the c-Ski/TβRI interaction and found that it can culminate in a constitutive association of TβRI with a nonfunctional R-Smad/Smad4 complex. Based on these findings, we hypothesize that the interaction between c-Ski and TβRI might interfere with nuclear translocation of the R-Smad/Smad4 complex, thereby attenuating TGF-β signaling. Such a mechanism may play a crucial role in tumor progression, because many tumors that express high levels of c-Ski also display impaired nuclear accumulation of Smads. ©2010 AACR.

Supervision of School and Youth Groups on Lift-Served Ski Slopes: A Research Perspective

ERIC Educational Resources Information Center

Brookes, Andrew; Holmes, Peter

2014-01-01

Supervised practice is a common feature of many snow sports excursions to downhill ski resorts by school or youth groups, often in combination with lessons from a ski school. What is the role of supervision in preventing mishaps, injury, or fatalities? This article presents results of a search of published snow sports safety research for evidence…

Alpine ski and snowboarding traumatic injuries: incidence, injury patterns, and risk factors for 10 years.

PubMed

McBeth, Paul B; Ball, Chad G; Mulloy, Robert H; Kirkpatrick, Andrew W

2009-05-01

Alpine skiing and snowboarding are popular winter sports in Canada. Every year participation in these activities results in traumatic injury. The purpose of this study was to identify the incidence and injury patterns, as well as risk factors associated with ski and snowboarding injuries. A comprehensive 10-year retrospective review of Alpine ski and snowboarding injuries from 1996 to 2006 was conducted. The Alberta Trauma Registry was used as the primary source of data. A total of 196 patients (56.6% skiers, 43.4% snowboarders) were identified as having major traumatic injuries (Injury Severity Score, >or=12). Forty-three patients required intensive care unit support. The majority of injuries were related to falls and collisions with natural objects. Head injuries were most common, followed by chest, spinal, and extremity trauma. Seventy-nine patients required emergency surgery. Skiing and snowboarding represent activities with high potential for traumatic injury. Safety initiatives should be developed to target this population.

The Winter Park Amputee Ski Teaching System.

ERIC Educational Resources Information Center

O'Leary, Hal

The three track method of teaching amputees to ski is presented in the illustrated manual. Problems unique to amputee skiers--care of hands, conditioning, care of stump, fatigue, excessive standing, wind, and balance--are discussed in terms of their implications to the amputee skier and practical solutions in attempting to solve them. Specific…

A local scale assessment of the climate change sensitivity of snow in Pyrenean ski resorts

NASA Astrophysics Data System (ADS)

Pesado, Cristina; Pons, Marc; Vilella, Marc; López-Moreno, Juan Ignacio

2016-04-01

The Pyrenees host one of the largest ski area in Europe after the Alps that encompasses the mountain area of the south of France, the north of Spain and the small country of Andorra. In this region, winter tourism is one of the main source of income and driving force of local development on these mountain communities. However, this activity was identified as one of the most vulnerable to a future climate change due to the projected decrease of natural snow and snowmaking capacity. However, within the same ski resorts different areas showed to have a very different vulnerability within the same resort based on the geographic features of the area and the technical management of the slopes. Different areas inside a same ski resort could have very different vulnerability to future climate change based on aspect, steepness or elevation. Furthermore, the technical management of ski resorts, such as snowmaking and grooming were identified to have a significant impact on the response of the snowpack in a warmer climate. In this line, two different ski resorts were deeply analyzed taken into account both local geographical features as well as the effect of the technical management of the runs. Principal Component Analysis was used to classify the main areas of the resort based on the geographic features (elevation, aspect and steepness) and identify the main representative areas with different local features. Snow energy and mass balance was simulated in the different representative areas using the Cold Regions Hydrological Model (CRHM) assuming different magnitudes of climate warming (increases of 2°C and 4°C in the mean winter temperature) both in natural conditions and assuming technical management of the slopes. Theses first results showed the different sensitivity and vulnerability to climate changes based on the local geography of the resort and the management of the ski runs, showing the importance to include these variables when analyzing the local vulnerability

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells

PubMed Central

Wang, Wei; Mariani, Francesca V.; Harland, Richard M.; Luo, Kunxin

2000-01-01

The bone morphogenic proteins (BMPs) play important roles in vertebrate development. In Xenopus, BMPs act as epidermal inducers and also as negative regulators of neurogenesis. Antagonism of BMP signaling results in neuralization. BMPs signal through the cell-surface receptors and downstream Smad molecules. Upon stimulation with BMP, Smad1, Smad5, and Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocate into the nucleus, where they regulate the expression of BMP target genes. Here, we show that the Ski oncoprotein can block BMP signaling and the expression of BMP-responsive genes in both Xenopus and mammalian cells by directly interacting with and repressing the activity of BMP-specific Smad complexes. This ability to antagonize BMP signaling results in neuralization by Ski in the Xenopus embryo and blocking of osteoblast differentiation of murine W-20-17 cells. Thus, Ski is able to repress the activity of all receptor-associated Smads and may regulate vertebrate development by modulating the signaling activity of transforming growth factor-β family members. PMID:11121043

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.

PubMed

Wang, W; Mariani, F V; Harland, R M; Luo, K

2000-12-19

The bone morphogenic proteins (BMPs) play important roles in vertebrate development. In Xenopus, BMPs act as epidermal inducers and also as negative regulators of neurogenesis. Antagonism of BMP signaling results in neuralization. BMPs signal through the cell-surface receptors and downstream Smad molecules. Upon stimulation with BMP, Smad1, Smad5, and Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocate into the nucleus, where they regulate the expression of BMP target genes. Here, we show that the Ski oncoprotein can block BMP signaling and the expression of BMP-responsive genes in both Xenopus and mammalian cells by directly interacting with and repressing the activity of BMP-specific Smad complexes. This ability to antagonize BMP signaling results in neuralization by Ski in the Xenopus embryo and blocking of osteoblast differentiation of murine W-20-17 cells. Thus, Ski is able to repress the activity of all receptor-associated Smads and may regulate vertebrate development by modulating the signaling activity of transforming growth factor-beta family members.

Killing-Yano tensor and supersymmetry of the self-dual Plebański-Demiański solution

NASA Astrophysics Data System (ADS)

Nozawa, Masato; Houri, Tsuyoshi

2016-06-01

We explore various aspects of the self-dual Plebański-Demiański (PD) family in the Euclidean Einstein-Maxwell-Λ system. The Killing-Yano tensor which was recently found by Yasui and one of the present authors allows us to prove that the self-dual PD metric can be brought into the self-dual Carter metric by an orientation-reversing coordinate transformation. We show that the self-dual PD solution admits two independent Killing spinors in the framework of N = 2 minimal gauged supergravity, whereas the non-self-dual solution admits only a single Killing spinor. This can be demonstrated by casting the self-dual PD metric into two distinct Przanowski-Tod forms. As a by-product, a new example of the three-dimensional Einstein-Weyl space is presented. We also prove that the self-dual PD metric falls into two different Calderbank-Pedersen families, which are determined by a single function subjected to a linear equation on the two-dimensional hyperbolic space. Furthermore, we consider the hyper-Kähler case for which the metric falls into the Gibbons-Hawking class. We find that the condition for the nonexistence of the Dirac-Misner string enforces the solution with a nonvanishing acceleration parameter to the Eguchi-Hanson space.

Are Ski and SnoN Involved in the Tumorigenesis of Oral Squamous Cell Carcinoma Through Smad4?

PubMed

Alaeddini, Mojgan; Etemad-Moghadam, Shahroo

2018-05-04

Transforming growth factor-β has been implicated in the tumorigenesis of oral squamous cell carcinoma (OSCC). Ski and SnoN are negative regulators of transforming growth factor-β/Smad pathway with both prooncogenic and antioncogenic functions in different cancers. The aim of this study was to assess the expression of Ski and SnoN in OSCC for the first time. Smad4 was also evaluated in these tumors. Clinical data on 61 primary OSCCs were gathered, and the specimens were subjected to immunohistochemical staining with monoclonal antibodies against SKI, SnoN, and Smad4 and scored semiquantitatively. Spearman rank, Fisher exact, and χ tests were used for statistical analysis, and P-value <0.05 was considered significant. Ski positivity and SnoN positivity were mostly cytoplasmic and found in 96.7% and 100% of the cases, respectively. Smad4 staining was low to negative in 65% of the specimens. No significant relationship was found either among the markers or between each of the proteins and the clinicopathologic data (P>0.05). According to our findings, Ski, SnoN, and Smad4 seem to play a role in OSCC oncogenesis, and we suggest that Ski and SnoN functions may take place independent of Smad4. Considering the dual and complex role of these proteins in tumorigenesis, further investigation to clarify the molecular pathways involved in their mode of action is suggested.

Wind and fairness in ski jumping: A computer modelling analysis.

PubMed

Jung, Alexander; Müller, Wolfram; Staat, Manfred

2018-06-25

Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping. Copyright © 2018 Elsevier Ltd. All rights reserved.

Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5.

PubMed

Tabata, Takanori; Kokura, Kenji; Ten Dijke, Peter; Ishii, Shunsuke

2009-01-01

The products encoded by ski and its related gene, sno, (Ski and Sno) act as transcriptional co-repressors and interact with other co-repressors such as N-CoR/SMRT and mSin3A. Ski and Sno mediate transcriptional repression by various repressors, including Mad, Rb and Gli3. Ski/Sno also suppress transcription induced by multiple activators, such as Smads and c-Myb. In particular, the inhibition of TGF-beta-induced transcription by binding to Smads is correlated with the oncogenic activity of Ski and Sno. However, the molecular mechanism by which Ski and Sno mediate transcriptional repression remains unknown. In this study, we report the purification and characterization of Ski complexes. The Ski complexes purified from HeLa cells contained histone deacetylase 3 (HDAC3) and protein arginine methyltransferase 5 (PRMT5), in addition to multiple Smad proteins (Smad2, Smad3 and Smad4). Chromatin immunoprecipitation assays indicated that these components of the Ski complexes were localized on the SMAD7 gene promoter, which is the TGF-beta target gene, in TGF-beta-untreated HepG2 cells. Knockdown of these components using siRNA led to up-regulation of SMAD7 mRNA. These results indicate that Ski complexes serve to maintain a TGF-beta-responsive promoter at a repressed basal level via the activities of histone deacetylase and histone arginine methyltransferase.

The Effect of 12 Weeks of Ski Training on Some Biometric Features of Girls

ERIC Educational Resources Information Center

Tas, Murat; Kiyici, Elif; Kiyci, Fatih

2018-01-01

The aim of this study was to investigate the effect of skiing on the biomotoric characteristics of children with evaluating tests of girls between the ages of eight and 14 before and after the season. The experimental group of this study was 15 girls who had just started skiing and the control group of 30 girls. In total, 45 volunteers joined the…

A biomechanical model for actively controlled snow ski bindings.

PubMed

Hull, M L; Ramming, J E

1980-11-01

Active control of snow ski bindings is a new design concept which potentially offers improved protection from lower extremity injury. Implementation of this concept entails measuring physical variables and calculating loading and/or deformation in injury prone musculoskeletal components. The subject of this paper is definition of a biomechanical model for calculating tibia torsion based on measurements of torsion loading between the boot and ski. Previous control schemes have used leg displacement only to indicate tibia torsion. The contributions of both inertial and velocity-dependent torques to tibia loading are explored and it is shown that both these moments must be included in addition to displacement-dependent moments. A new analog controller design which includes inertia, damping, and stiffness terms in the tibia load calculation is also presented.

78 FR 60816 - Proposed Directive for Additional Seasonal or Year-Round Recreation Activities at Ski Areas

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... Authorized Officers to ensure that ski area operations comply with Forest Service regulations and permit... significant modifications to topography to facilitate construction or operations. The Agency is also proposing... in the ski area's master development plan; (2) Not compromise snow sports operations or functions...

Automatic Identification of Subtechniques in Skating-Style Roller Skiing Using Inertial Sensors

PubMed Central

Sakurai, Yoshihisa; Fujita, Zenya; Ishige, Yusuke

2016-01-01

This study aims to develop and validate an automated system for identifying skating-style cross-country subtechniques using inertial sensors. In the first experiment, the performance of a male cross-country skier was used to develop an automated identification system. In the second, eight male and seven female college cross-country skiers participated to validate the developed identification system. Each subject wore inertial sensors on both wrists and both roller skis, and a small video camera on a backpack. All subjects skied through a 3450 m roller ski course using a skating style at their maximum speed. The adopted subtechniques were identified by the automated method based on the data obtained from the sensors, as well as by visual observations from a video recording of the same ski run. The system correctly identified 6418 subtechniques from a total of 6768 cycles, which indicates an accuracy of 94.8%. The precisions of the automatic system for identifying the V1R, V1L, V2R, V2L, V2AR, and V2AL subtechniques were 87.6%, 87.0%, 97.5%, 97.8%, 92.1%, and 92.0%, respectively. Most incorrect identification cases occurred during a subtechnique identification that included a transition and turn event. Identification accuracy can be improved by separately identifying transition and turn events. This system could be used to evaluate each skier’s subtechniques in course conditions. PMID:27049388

Confronting the demand and supply of snow seasonal forecasts for ski resorts : the case of French Alps

NASA Astrophysics Data System (ADS)

Dubois, Ghislain

2017-04-01

Alpine ski resorts are highly dependent on snow, which availability is characterized by a both a high inter-annual variability and a gradual diminution due to climate change. Due to this dependency to climatic resources, the ski industry is increasingly affected by climate change: higher temperatures limit snow falls, increase melting and limit the possibilities of technical snow making. Therefore, since the seventies, managers drastically improved their practices, both to adapt to climate change and to this inter-annual variability of snow conditions. Through slope preparation and maintenance, snow stock management, artificial snow making, a typical resort can approximately keep the same season duration with 30% less snow. The ski industry became an activity of high technicity The EUPORIAS FP7 (www.euporias.eu) project developed between 2012 and 2016 a deep understanding of the supply and demand conditions for the provision of climate services disseminating seasonal forecasts. In particular, we developed a case study, which allowed conducting several activities for a better understanding of the demand and of the business model of future services applied to the ski industry. The investigations conducted in France inventoried the existing tools and databases, assessed the decision making process and data needs of ski operators, and provided evidences that some discernable skill of seasonal forecasts exist. This case study formed the basis of the recently funded PROSNOW H2020 project. We will present the main results of EUPORIAS project for the ski industry.

Adaptive downhill skiing in children with cerebral palsy: effect on gross motor function.

PubMed

Sterba, John A

2006-01-01

The study was designed to examine the effect of adaptive downhill skiing (ADS) on gross motor function in children with spastic cerebral palsy. One girl and four boys participated (mean age = eight years, five months). All were ambulatory. Participants' Gross Motor Function Measure (GMFM) classifications were: Level I (n = 2); Level II (n = 2); Level III (n = 1). ADS was conducted for a 10-week period at one ski resort. Each participant had the same ski instructor. GMFM was obtained every five weeks: beginning five weeks before ADS instruction and continuing to 10 weeks after ADS instruction. After 10 weeks of ADS GMFM-D, and GMFM-Total Score increased 5.4% (p = 0.022) and 3.2% (p = 0.035), respectively, and remained increased 10 weeks after ADS. ADS could be recommended by clinicians as a recreational activity for the gross motor rehabilitation of ambulatory children with spastic cerebral palsy.

Analysis of a severe head injury in World Cup alpine skiing.

PubMed

Yamazaki, Junya; Gilgien, Matthias; Kleiven, Svein; McIntosh, Andrew S; Nachbauer, Werner; Müller, Erich; Bere, Tone; Bahr, Roald; Krosshaug, Tron

2015-06-01

Traumatic brain injury (TBI) is the leading cause of death in alpine skiing. It has been found that helmet use can reduce the incidence of head injuries between 15% and 60%. However, knowledge on optimal helmet performance criteria in World Cup alpine skiing is currently limited owing to the lack of biomechanical data from real crash situations. This study aimed to estimate impact velocities in a severe TBI case in World Cup alpine skiing. Video sequences from a TBI case in World Cup alpine skiing were analyzed using a model-based image matching technique. Video sequences from four camera views were obtained in full high-definition (1080p) format. A three-dimensional model of the course was built based on accurate measurements of piste landmarks and matched to the background video footage using the animation software Poser 4. A trunk-neck-head model was used for tracking the skier's trajectory. Immediately before head impact, the downward velocity component was estimated to be 8 m·s⁻¹. After impact, the upward velocity was 3 m·s⁻¹, whereas the velocity parallel to the slope surface was reduced from 33 m·s⁻¹ to 22 m·s⁻¹. The frontal plane angular velocity of the head changed from 80 rad·s⁻¹ left tilt immediately before impact to 20 rad·s⁻¹ right tilt immediately after impact. A unique combination of high-definition video footage and accurate measurements of landmarks in the slope made possible a high-quality analysis of head impact velocity in a severe TBI case. The estimates can provide crucial information on how to prevent TBI through helmet performance criteria and design.

Curanderismo in Taos County, New Mexico--a possible case of anthropological romanticism?

PubMed

Scheper-Hughes, N; Stewart, D

1983-12-01

Interviews with 25 Spanish-Americans of Taos County, New Mexico, indicate that time and acculturation have greatly eroded the belief in and practice of curanderismo, the traditional folk medical system of the Southwest. Curanderismo in northern New Mexico today has moved from being a primary and important source of medical care to one used alternatively and very occasionally in cases of pediatric disorders, chronic illnesses and pain, and for those maladies still classified according to the traditional folk beliefs.

A comparison of wakeboard-, water skiing-, and tubing-related injuries in the United States, 2000-2007.

PubMed

Baker, John I; Griffin, Russell; Brauneis, Paul F; Rue, Loring W; McGwin, Gerald

2010-01-01

The purpose of the study was to compare tubing-related injuries to wakeboarding- and water skiing-related injuries. Data was collected from the 2000-2007 National Electronic Injury Surveillance Survey for 1,761 individuals seeking care at an emergency department due to a tubing-, wakeboarding, or water skiing-related injury. Data included patient age and sex, as well as injury characteristics including body region injured (i.e., head and neck, trunk, shoulder and upper extremity, and hip and lower extremity) and diagnosis of injury (e.g., contusion, laceration, or fracture). Case narratives were reviewed to ensure that a tubing-, wakeboarding-, or water skiing-related injury occurred while the individual was being towed behind a boat. Severe injury (defined as an injury resulting in the individual being hospitalized, transferred, held for observation) was compared among the groups using logistic regression. Wakeboard- and tubing-related injuries more commonly involved the head and neck, while water skiing- related injuries were likely to involve the hip and lower extremity. Tubing-related injuries, compared to water skiing-related injuries, were more likely to be severe (OR 2.31, 95% CI 1.23-4. 33). Like wakeboarding and water skiing, tubing has inherent risks that must be understood by the participant. While tubing is generally considered a safer alternative to wakeboarding and water skiing, the results of the current study suggest otherwise. Both the number and severity of tubing- related injuries could be prevented through means such as advocating the use of protective wear such as helmets while riding a tube or having recommended safe towing speeds prominently placed on inner tubes. Key pointsIncrease annual injury rate trend in wakeboard injuries.Wakeboard- and tubing-related injuries more often to head and neck, waterskiing-related injuries more often to hip and lower extremity.Tubing-related injuries over 2-times as likely to be severe compared to

Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis.

PubMed

Medrano, Estela E

2003-05-19

Transforming growth factor-beta (TGF-beta ) has dual and paradoxical functions as a tumor suppressor and promoter of tumor progression and metastasis. TGF-Ji-mediated growth inhibition is gradually lost during melanoma tumor progression, but there are no measurable defects at the receptor level. Furthermore, melanoma cells release high levels of TGF-beta to the microenvironment, which upon activation induces matrix deposition, angiogenesis, survival, and transition to more aggressive phenotypes. The SKI and SnoN protein family associate with and repress the activity of Smad2, Smad3, and Smad4, three members of the TGF-fl signaling pathway. SKI also facilitates cell-cycle progression by targeting the RB pathway by at least two ways: it directly associates with RB and represses its activity when expressed at high levels, and indirectly, it represses Smad-mediated induction of p21(Waf-1) This results in increased CDK2 activity, RB phosphorylation,and inactivation. Therefore, high levels of SKI result in lesions to the RB pathway in a manner similar to p16 (INK4a) loss. SKI mRNA and protein levels dramatically increase during human melanoma tumor progression. In addition,the SKI protein shifts from nuclear localization in intraepidermal melanoma cells to nuclear and cytoplasmic in invasive and metastatic melanomas. Here, I discuss the basis for repression of intracellular TGF-beta signaling by SKI, some additional activities of this protein, and propose that by disrupting multiple tumor suppressor pathways, SKI functions as a melanoma oncogene.

The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation.

PubMed

Prunier, Celine; Pessah, Marcia; Ferrand, Nathalie; Seo, Su Ryeon; Howe, Philip; Atfi, Azeddine

2003-07-11

The phosphorylation of Smad2 and Smad3 by the transforming growth factor (TGF)-beta-activated receptor kinases and their subsequent heterodimerization with Smad4 and translocation to the nucleus form the basis for a model how Smad proteins work to transmit TGF-beta signals. The transcriptional activity of Smad2-Smad4 or Smad3-Smad4 complexes can be limited by the corepressor Ski, which is believed to interact with Smad complexes on TGF-beta-responsive promoters and represses their ability to activate TGF-beta target genes by assembling on DNA a repressor complex containing histone deacetylase. Here we show that Ski can block TGF-beta signaling by interfering with the phosphorylation of Smad2 and Smad3 by the activated TGF-beta type I receptor. Furthermore, we demonstrate that overexpression of Ski induces the assembly of Smad2-Smad4 and Smad3-Smad4 complexes independent of TGF-beta signaling. The ability of Ski to engage Smad proteins in nonproductive complexes provides new insights into the molecular mechanism used by Ski for disabling TGF-beta signaling.

Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski

PubMed Central

Marcelain, Katherine; Armisen, Ricardo; Aguirre, Adam; Ueki, Nobuhide; Toro, Jessica; Colmenares, Clemencia; Hayman, Michael J

2011-01-01

Ski is a transcriptional regulator that has been considered an oncoprotein, given its ability to induce oncogenic transformation in avian model systems. However, studies in mouse and in some human tumor cells have also indicated a tumor suppressor activity for this protein. We found that Ski−/− mouse embryo fibroblasts exhibit high levels of genome instability, namely aneuploidy, consistent with a tumor suppressor function for Ski. Time-lapse microscopy revealed lagging chromosomes and chromatin/chromosome bridges as the major cause of micronuclei formation and the subsequent aneuploidy. Although these cells arrested in mitosis after treatment with spindle disrupting drugs and exhibited a delayed metaphase/anaphase transition, Spindle Assembly Checkpoint (SAC) was not sufficient to prevent chromosome missegregation, consistent with a weakened SAC. Our in vivo analysis also showed dynamic metaphase plate rearrangements with switches in polarity in cells arrested in metaphase. Importantly, after ectopic expression of Ski the cells that displayed this metaphase arrest died directly during metaphase or after aberrant cell division, relating SAC activation and mitotic cell death. This increased susceptibility to undergo mitosis-associated cell death reduced the number of micronuclei-containing cells. The presented data support a new role for Ski in the mitotic process and in maintenance of genetic stability, providing insights into the mechanism of tumor suppression mediated by this protein. PMID:21412778

[Doctor's degree thesis of Tomasz Adolf Wołkowiński "Carditidis rheumaticae historia"].

PubMed

Stembrowicz, W

2001-01-01

In 1817 on the University of Vilnius Faculty of Medicine, T. A. Wołkowiński, a student of the eminent clinician Józef Frank, defended his doctor's degree thesis about a direct relation between rheumatic disease and cardiomegaly. It was probably the first paper in Poland describing with details the rheumatic heart disease. Unfortunately we don't know much about T. A. Wołkowiński's life.

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.

PubMed

Luo, K; Stroschein, S L; Wang, W; Chen, D; Martens, E; Zhou, S; Zhou, Q

1999-09-01

Smad proteins are critical signal transducers downstream of the receptors of the transforming growth factor-beta (TGFbeta) superfamily. On phosphorylation and activation by the active TGFbeta receptor complex, Smad2 and Smad3 form hetero-oligomers with Smad4 and translocate into the nucleus, where they interact with different cellular partners, bind to DNA, regulate transcription of various downstream response genes, and cross-talk with other signaling pathways. Here we show that a nuclear oncoprotein, Ski, can interact directly with Smad2, Smad3, and Smad4 on a TGFbeta-responsive promoter element and repress their abilities to activate transcription through recruitment of the nuclear transcriptional corepressor N-CoR and possibly its associated histone deacetylase complex. Overexpression of Ski in a TGFbeta-responsive cell line renders it resistant to TGFbeta-induced growth inhibition and defective in activation of JunB expression. This ability to overcome TGFbeta-induced growth arrest may be responsible for the transforming activity of Ski in human and avian cancer cells. Our studies suggest a new paradigm for inactivation of the Smad proteins by an oncoprotein through transcriptional repression.

The SKI-HI Program: A Descriptive Update, 1986.

ERIC Educational Resources Information Center

Bruce, Sandy; And Others

This document provides updated information on the SKI-HI program model which presently serves over 2000 young hearing impaired children in 35 states and Canada. The program focuses on training parents in the skills needed to maximize language stimulation and minimize language deprivation. Among 14 educational and philosophical underpinnings of the…

Curanderismo in Taos County, New Mexico—A Possible Case of Anthropological Romanticism?

PubMed Central

Scheper-Hughes, Nancy; Stewart, David

1983-01-01

Interviews with 25 Spanish-Americans of Taos County, New Mexico, indicate that time and acculturation have greatly eroded the belief in and practice of curanderismo, the traditional folk medical system of the Southwest. Curanderismo in northern New Mexico today has moved from being a primary and important source of medical care to one used alternatively and very occasionally in cases of pediatric disorders, chronic illnesses and pain, and for those maladies still classified according to the traditional folk beliefs. PMID:6666104

Gait models and mechanical energy in three cross-country skiing techniques.

PubMed

Pellegrini, Barbara; Zoppirolli, Chiara; Bortolan, Lorenzo; Zamparo, Paola; Schena, Federico

2014-11-01

Fluctuations in mechanical energy of the body center of mass (COM) have been widely analyzed when investigating different gaits in human and animal locomotion. We applied this approach to estimate the mechanical work in cross-country skiing and to identify the fundamental mechanisms of this particular form of locomotion. We acquired movements of body segments, skis, poles and plantar pressures for eight skiers while they roller skied on a treadmill at 14 km h(-1) and a 2 deg slope using three different techniques (diagonal stride, DS; double poling, DP; double poling with kick, DK). The work associated with kinetic energy (KE) changes of COM was not different between techniques; the work against gravity associated with potential energy (PE) changes was higher for DP than for DK and was lowest for DS. Mechanical work against the external environment was 0.87 J m(-1) kg(-1) for DS, 0.70 J m(-1) kg(-1) for DP and 0.79 J m(-1) kg(-1) for DK. The work done to overcome frictional forces, which is negligible in walking and running, was 17.8%, 32.3% and 24.8% of external mechanical work for DS, DP and DK, respectively. The pendulum-like recovery (R%) between PE and KE was ~45%, ~26% and ~9% for DP, DK and DS, respectively, but energy losses by friction are not accounted for in this computation. The pattern of fluctuations of PE and KE indicates that DS can be described as a 'grounded running', where aerial phases are substituted by ski gliding phases, DP can be described as a pendular gait, whereas DK is a combination of both. © 2014. Published by The Company of Biologists Ltd.

Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition.

PubMed

Tessé, Sophie; Storlazzi, Aurora; Kleckner, Nancy; Gargano, Silvana; Zickler, Denise

2003-10-28

Ski8p is implicated in degradation of non-poly(A) and double-stranded RNA, and in meiotic DNA recombination. We have identified the Sordaria macrospora SKI8 gene. Ski8p is cytoplasmically localized in all vegetative and sexual cycle cells, and is nuclear localized, specifically in early-mid-meiotic prophase, in temporal correlation with Spo11p, the meiotic double-strand break (DSB) transesterase. Localizations of Ski8p and Spo11p are mutually interdependent. ski8 mutants exhibit defects in vegetative growth, entry into the sexual program, and sporulation. Diverse meiotic defects, also seen in spo11 mutants, are diagnostic of DSB absence, and they are restored by exogenous DSBs. These results suggest that Ski8p promotes meiotic DSB formation by acting directly within meiotic prophase chromosomes. Mutant phenotypes also divide meiotic homolog juxtaposition into three successive, mechanistically distinct steps; recognition, presynaptic alignment, and synapsis, which are distinguished by their differential dependence on DSBs.

Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition

PubMed Central

Tessé, Sophie; Storlazzi, Aurora; Kleckner, Nancy; Gargano, Silvana; Zickler, Denise

2003-01-01

Ski8p is implicated in degradation of non-poly(A) and double-stranded RNA, and in meiotic DNA recombination. We have identified the Sordaria macrospora SKI8 gene. Ski8p is cytoplasmically localized in all vegetative and sexual cycle cells, and is nuclear localized, specifically in early-mid-meiotic prophase, in temporal correlation with Spo11p, the meiotic double-strand break (DSB) transesterase. Localizations of Ski8p and Spo11p are mutually interdependent. ski8 mutants exhibit defects in vegetative growth, entry into the sexual program, and sporulation. Diverse meiotic defects, also seen in spo11 mutants, are diagnostic of DSB absence, and they are restored by exogenous DSBs. These results suggest that Ski8p promotes meiotic DSB formation by acting directly within meiotic prophase chromosomes. Mutant phenotypes also divide meiotic homolog juxtaposition into three successive, mechanistically distinct steps; recognition, presynaptic alignment, and synapsis, which are distinguished by their differential dependence on DSBs. PMID:14563920

Phase relationships in the BaO-Ga2O3-Ta2O5 system and the structure of Ba6Ga21TaO40.

PubMed

Cao, Jiang; Yu, Xiaodi; Kuang, Xiaojun; Su, Qiang

2012-07-16

Phase relationships in the BaO-Ga(2)O(3)-Ta(2)O(5) ternary system at 1200 °C were determined. The A(6)B(10)O(30) tetragonal tungsten bronze (TTB) related solution in the BaO-Ta(2)O(5) subsystem dissolved up to ~11 mol % Ga(2)O(3), forming a ternary trapezoid-shaped TTB-related solid solution region defined by the BaTa(2)O(6), Ba(1.1)Ta(5)O(13.6), Ba(1.58)Ga(0.92)Ta(4.08)O(13.16), and Ba(6)GaTa(9)O(30) compositions in the BaO-Ga(2)O(3)-Ta(2)O(5) system. Two ternary phases Ba(6)Ga(21)TaO(40) and eight-layer twinned hexagonal perovskite solid solution Ba(8)Ga(4-x)Ta(4+0.6x)O(24) were confirmed in the BaO-Ga(2)O(3)-Ta(2)O(5) system. Ba(6)Ga(21)TaO(40) crystallized in a monoclinic cell of a = 15.9130(2) Å, b = 11.7309(1) Å, c = 5.13593(6) Å, β = 107.7893(9)°, and Z = 1 in space group C2/m. The structure of Ba(6)Ga(21)TaO(40) was solved by the charge flipping method, and it represents a three-dimensional (3D) mixed GaO(4) tetrahedral and GaO(6)/TaO(6) octahedral framework, forming mixed 1D 5/6-fold tunnels that accommodate the Ba cations along the c axis. The electrical property of Ba(6)Ga(21)TaO(40) was characterized by using ac impedance spectroscopy.

Natural hazards in the Alps triggered by ski slope engineering and artificial snow production

NASA Astrophysics Data System (ADS)

de Jong, C.

2012-04-01

In the Alps there is increasing concern of man-made triggering of natural hazards in association with ski slope engineering and pressures from climate change. However literature on the topic is rare. Ski run development has been intensified in the past decade to accommodate a higher density of skiers. In order to absorb the increased flux of skiers promoted by continually increasing lift capacity, ski runs are subject to more and more enlargement, straightening and leveling. This has required large-scale re-leveling of slopes with the removal of soil and protective vegetation using heavy machinery during the summer season. Slope-ward incision on steep slopes, creation of artificial embankments by leeward deposition and development of straight ski runs perpendicular to steep slopes have resulted in both shallow and deep erosion, gullying, triggering of small landslides and even bedload transport in marginal channels. Other natural hazards have been triggered directly or indirectly due to intensification of artificial snow production. This has increased exponentially in the last decade in order to secure the skiing season under increasingly warm temperatures and erratic snowfall and decreasing snow depth and snow duration in association with climate change. The consequences are multiple. Firstly, in order to economize both costs and quantity of artificial snow production, ski runs are leveled as far as possible in order to avoid topographical irregularities, protruding vegetation or rocks. The combination of topsoil removal and prolonged duration of artificial snow cover results in a decreased vegetation cover and period as well as species alteration. Together with greatly decreased permeability of the underground, snowmelt and intensive summer precipitation trigger surface runoff, erosion and even small landslides. After more than a decade of intensive cover by artificial snow, most such steep ski runs at altitudes above 1400 m are reduced into highly erosive

Sidecut radius and kinetic energy: equipment designed to reduce risk of severe traumatic knee injuries in alpine giant slalom ski racing

PubMed Central

Kröll, Josef; Spörri, Jörg; Gilgien, Matthias; Schwameder, Hermann; Müller, Erich

2016-01-01

Background Kinetic energy (Ekin) increases with speed by the power of 2 and is considered a major risk factor for injuries in alpine ski racing. There is no empirical knowledge about the effect of ski geometry on Ekin. Consequently, the aim of this study was to investigate the influence of sidecut radius on the progress of Ekin while skiing through a multigate section in giant slalom (GS). Methods 5 European-Cup level athletes skied on three different pairs of GS skis varying in sidecut radii (30, 35 and 40 m). Each athlete's position over time within a six gate section (including flat and steep terrain) was captured by the use of a differential Global Navigational Satellite System. Ekin, speed, time and path length were analysed for each pair of skis used. Results When using skis with greater sidecut radius, average Ekin was significantly lower over the entire six gate section, but not locally at every turn cycle. Particular decreases of Ekin were observed for both turns on the flat terrain, as well as for the turn at the terrain transition and the first turn on the steep terrain. The observed decreases in Ekin were found to be primarily explainable by increases in turn time. Conclusions With respect to typical sport mechanisms that cause severe knee injuries, using skis with greater sidecut radius potentially provides additional injury preventative gain, particularly in specific areas within a run. However, this injury preventative gain during falls in GS should not be overestimated. PMID:26702015

Perceived key injury risk factors in World Cup alpine ski racing—an explorative qualitative study with expert stakeholders

PubMed Central

Spörri, Jörg; Kröll, Josef; Amesberger, Günter; Blake, Ollie M; Müller, Erich

2012-01-01

Background There is limited knowledge about key injury risk factors in alpine ski racing, particularly for World Cup (WC) athletes. Objective This study was undertaken to compile and explore perceived intrinsic and extrinsic risk factors for severe injuries in WC alpine ski racing. Methods Qualitative study. Interviews were conducted with 61 expert stakeholders of the WC ski racing community. Experts’ statements were collected, paraphrased and loaded into a database with inductively derived risk factor categories (Risk Factor Analysis). At the end of the interviews, experts were asked to name those risk factors they believed to have a high potential impact on injury risk and to rank them according to their priority of impact (Risk Factor Rating). Results In total, 32 perceived risk factors categories were derived from the interviews within the basic categories Athlete, Course, Equipment and Snow. Regarding their perceived impact on injury risk, the experts’ top five categories were: system ski, binding, plate and boot; changing snow conditions; physical aspects of the athletes; speed and course setting aspects and speed in general. Conclusions Severe injuries in WC alpine ski racing can have various causes. This study compiled a list of perceived intrinsic and extrinsic risk factors and explored those factors with the highest believed impact on injury risk. Hence, by using more detailed hypotheses derived from this explorative study, further studies should verify the plausibility of these factors as true risk factors for severe injuries in WC alpine ski racing. PMID:22872684

Forces and mechanical energy fluctuations during diagonal stride roller skiing; running on wheels?

PubMed

Kehler, Alyse L; Hajkova, Eliska; Holmberg, Hans-Christer; Kram, Rodger

2014-11-01

Mechanical energy can be conserved during terrestrial locomotion in two ways: the inverted pendulum mechanism for walking and the spring-mass mechanism for running. Here, we investigated whether diagonal stride cross-country roller skiing (DIA) utilizes similar mechanisms. Based on previous studies, we hypothesized that running and DIA would share similar phase relationships and magnitudes of kinetic energy (KE), and gravitational potential energy (GPE) fluctuations, indicating elastic energy storage and return, as if roller skiing is like 'running on wheels'. Experienced skiers (N=9) walked and ran at 1.25 and 3 m s(-1), respectively, and roller skied with DIA at both speeds on a level dual-belt treadmill that recorded perpendicular and parallel forces. We calculated the KE and GPE of the center of mass from the force recordings. As expected, the KE and GPE fluctuated with an out-of-phase pattern during walking and an in-phase pattern during running. Unlike walking, during DIA, the KE and GPE fluctuations were in phase, as they are in running. However, during the glide phase, KE was dissipated as frictional heat and could not be stored elastically in the tendons, as in running. Elastic energy storage and return epitomize running and thus we reject our hypothesis. Diagonal stride cross-country skiing is a biomechanically unique movement that only superficially resembles walking or running. © 2014. Published by The Company of Biologists Ltd.

The use of computer graphics in the visual analysis of the proposed Sunshine Ski Area expansion

Treesearch

Mark Angelo

1979-01-01

This paper describes the use of computer graphics in designing part of the Sunshine Ski Area in Banff National Park. The program used was capable of generating perspective landscape drawings from a number of different viewpoints. This allowed managers to predict, and subsequently reduce, the adverse visual impacts of ski-run development. Computer graphics have proven,...

The Effects of Short-Term Ski Trainings on Dynamic Balance Performance and Vertical Jump in Adolescents

ERIC Educational Resources Information Center

Camliguney, Asiye Filiz

2013-01-01

Skiing is a sport where balance and strength are critical and which can be practiced actively especially from early years to old age. The purpose of this study is to examine the effect of a 5-day training of skiing skills on dynamic balance performance and development of vertical jump strength in adolescents. Sixteen adolescent volunteers who do…

NFI-Ski interactions mediate transforming growth factor beta modulation of human papillomavirus type 16 early gene expression.

PubMed

Baldwin, Amy; Pirisi, Lucia; Creek, Kim E

2004-04-01

Human papillomaviruses (HPVs) are present in virtually all cervical cancers. An important step in the development of malignant disease, including cervical cancer, involves a loss of sensitivity to transforming growth factor beta (TGF-beta). HPV type 16 (HPV16) early gene expression, including that of the E6 and E7 oncoprotein genes, is under the control of the upstream regulatory region (URR), and E6 and E7 expression in HPV16-immortalized human epithelial cells is inhibited at the transcriptional level by TGF-beta. While the URR contains a myriad of transcription factor binding sites, including seven binding sites for nuclear factor I (NFI), the specific sequences within the URR or the transcription factors responsible for TGF-beta modulation of the URR remain unknown. To identify potential transcription factors and binding sites involved in TGF-beta modulation of the URR, we performed DNase I footprint analysis on the HPV16 URR using nuclear extracts from TGF-beta-sensitive HPV16-immortalized human keratinocytes (HKc/HPV16) treated with and without TGF-beta. Differentially protected regions were found to be located around NFI binding sites. Electrophoretic mobility shift assays, using the NFI binding sites as probes, showed decreased binding upon TGF-beta treatment. This decrease in binding was not due to reduced NFI protein or NFI mRNA levels. Mutational analysis of individual and multiple NFI binding sites in the URR defined their role in TGF-beta sensitivity of the promoter. Overexpression of the NFI family members in HKc/HPV16 decreased the ability of TGF-beta to inhibit the URR. Since the oncoprotein Ski has been shown to interact with and increase the transcriptional activity of NFI and since cellular Ski levels are decreased by TGF-beta treatment, we explored the possibility that Ski may provide a link between TGF-beta signaling and NFI activity. Anti-NFI antibodies coimmunoprecipitated endogenous Ski in nuclear extracts from HKc/HPV16, confirming that NFI

PROSNOW - Provision of a prediction system allowing for management and optimization of snow in Alpine ski resorts

NASA Astrophysics Data System (ADS)

Morin, Samuel; Ghislain, Dubois

2017-04-01

Snow on the ground is a critical resource for mountain regions to sustain river flow, to provide freshwater input to ecosystems and to support winter tourism, in particular in ski resorts. The level of activity, employment, turnover and profit of hundreds of ski resorts in the European Alps primarily depends on meteorological conditions, in particular natural snowfall but also increasingly conditions favourable for snowmaking (production of machine made snow, also referred to as technical snow). Ski resorts highly depend on appropriate conditions for snowmaking (mainly the availability of cold water, as well as sub-freezing temperature with sufficiently low humidity conditions). However, beyond the time scale of weather forecasts (a few days), managers of ski resorts have to rely on various and scattered sources of information, hampering their ability to cope with highly variable meteorological conditions. Improved anticipation capabilities at all time scales, spanning from "weather forecast" (up to 5 days typically) to "climate prediction" at the seasonal scale (up to several months) holds significant potential to increase the resilience of socio-economic stakeholders and supports their real-time adaptation potential. To address this issue, the recently funded (2017-2020) H2020 PROSNOW project will build a demonstrator of a meteorological and climate prediction and snow management system from one week to several months ahead, specifically tailored to the needs of the ski industry. PROSNOW will apply state-of-the-art knowledge relevant to the predictability of atmospheric and snow conditions, and investigate and document the added value of such services. The project proposes an Alpine-wide system (including ski resorts located in France, Switzerland, Germany, Austria and Italy). It will join and link providers of weather forecasts and climate predictions at the seasonal scale, research institutions specializing in snowpack modelling, a relevant ensemble of at least

Effects of frequency on gross efficiency and performance in roller ski skating.

PubMed

Leirdal, S; Sandbakk, O; Ettema, G

2013-06-01

The purpose of the present study was to examine the effect of frequency on efficiency and performance during G3 roller ski skating. Eight well-trained male cross-country skiers performed three submaximal 5-min speeds (10, 13, and 16 km/h) and a time-to-exhaustion (TTE) performance (at 20 km/h) using the G3 skating technique using freely chosen, high, and low frequency at all four speeds. All tests were done using roller skis on a large treadmill at 5% incline. Gross efficiency (GE) was calculated as power divided by metabolic rate. Power was calculated as the sum of power against frictional forces and power against gravity. Metabolic rate was calculated from oxygen consumption and blood lactate concentration. Freely chosen frequency increased from 60 to 70 strokes/min as speed increased from 10 to 20 km/h. GE increased with power. At high power (20 km/h performance test), both efficiency and performance were significantly reduced by high frequency. In regard to choice of frequency during G3 roller ski skating, cross-country skiers seems to be self-optimized both in relation to energy saving (efficiency) and performance (TTE). © 2011 John Wiley & Sons A/S.

The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling

PubMed Central

Luo, Kunxin; Stroschein, Shannon L.; Wang, Wei; Chen, Dan; Martens, Eric; Zhou, Sharleen; Zhou, Qiang

1999-01-01

Smad proteins are critical signal transducers downstream of the receptors of the transforming growth factor-β (TGFβ) superfamily. On phosphorylation and activation by the active TGFβ receptor complex, Smad2 and Smad3 form hetero-oligomers with Smad4 and translocate into the nucleus, where they interact with different cellular partners, bind to DNA, regulate transcription of various downstream response genes, and cross-talk with other signaling pathways. Here we show that a nuclear oncoprotein, Ski, can interact directly with Smad2, Smad3, and Smad4 on a TGFβ-responsive promoter element and repress their abilities to activate transcription through recruitment of the nuclear transcriptional corepressor N-CoR and possibly its associated histone deacetylase complex. Overexpression of Ski in a TGFβ-responsive cell line renders it resistant to TGFβ-induced growth inhibition and defective in activation of JunB expression. This ability to overcome TGFβ-induced growth arrest may be responsible for the transforming activity of Ski in human and avian cancer cells. Our studies suggest a new paradigm for inactivation of the Smad proteins by an oncoprotein through transcriptional repression. PMID:10485843

Differential role of Sloan–Kettering Institute (Ski) protein in Nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells

PubMed Central

Khan, Shafiq A.

2012-01-01

Transforming growth factor-beta (TGF-β) signaling pathways contain both tumor suppressor and tumor promoting activities. We have demonstrated that Nodal, another member of the TGF-β superfamily, and its receptors are expressed in prostate cancer cells. Nodal and TGF-β exerted similar biological effects on prostate cells; both inhibited proliferation in WPE, RWPE1 and DU145 cells, whereas neither had any effect on the proliferation of LNCaP or PC3 cells. Interestingly, Nodal and TGF-β induced migration in PC3 cells, but not in DU145 cells. TGF-β induced predominantly phosphorylation of Smad3, whereas Nodal induced phosphorylation of only Smad2. We also determined the expression and differential role of Ski, a corepressor of Smad2/3, in Nodal and TGF-β signaling in prostate cancer cells. Similar levels of Ski mRNA were found in several established prostate cell lines; however, high levels of Ski protein were only detected in prostate cancer cells and prostate cancer tissue samples. Exogenous Nodal and TGF-β had no effects on Ski mRNA levels. On the other hand, TGF-β induced a rapid degradation of Ski protein mediated by the proteasomal pathway, whereas Nodal had no effect on Ski protein. Reduced Ski levels correlated with increased basal and TGF-β-induced Smad2/3 phosphorylation. Knockdown of endogenous Ski reduced proliferation in DU145 cells and enhanced migration of PC3 cells. We conclude that high levels of Ski expression in prostate cancer cells may be responsible for repression of TGF-β and Smad3 signaling, but Ski protein levels do not influence Nodal and Smad2 signaling. PMID:22843506

Dissemination of go sun smart in outdoor recreation: effect of program exposure on sun protection of guests at high-altitude ski areas.

PubMed

Walkosz, Barbara J; Buller, David B; Andersen, Peter A; Scott, Michael D; Dignan, Mark B; Cutter, Gary R; Liu, Xia; Maloy, Julie A

2014-09-01

Go Sun Smart is a theory-based health communication program designed to influence sun-protection behaviors of employees and guests at high-altitude ski areas to reduce skin cancer risk. The effects of Go Sun Smart, in a Phase IV dissemination randomized posttest-only trial, on sun-protection behaviors of ski area guests are reported. Program use was assessed by on-site observation and guest message exposure, and sun protection was measured in intercept surveys at ski areas. Dissemination strategy-enhanced versus basic-was not significantly related to sun safety practices. Additional analyses examined the relation between message exposure and guests' sun safety practices. Ski areas displaying at least 6 Go Sun Smart materials in guest-only areas and 9 Go Sun Smart materials throughout the area increased guests' message exposure. Higher message exposure within the high-use ski areas was associated with improved sun protection by guests but not within the low-use ski areas. The authors underscore the importance of program implementation and message exposure on the success of evidence-based health communication efforts applied industrywide.

Using the power balance model to simulate cross-country skiing on varying terrain.

PubMed

Moxnes, John F; Sandbakk, Oyvind; Hausken, Kjell

2014-01-01

The current study adapts the power balance model to simulate cross-country skiing on varying terrain. We assumed that the skier's locomotive power at a self-chosen pace is a function of speed, which is impacted by friction, incline, air drag, and mass. An elite male skier's position along the track during ski skating was simulated and compared with his experimental data. As input values in the model, air drag and friction were estimated from the literature based on the skier's mass, snow conditions, and speed. We regard the fit as good, since the difference in racing time between simulations and measurements was 2 seconds of the 815 seconds racing time, with acceptable fit both in uphill and downhill terrain. Using this model, we estimated the influence of changes in various factors such as air drag, friction, and body mass on performance. In conclusion, the power balance model with locomotive power as a function of speed was found to be a valid tool for analyzing performance in cross-country skiing.

Effect of a skiing intervention on the psycho-physiological reactivity and recovery in the elderly.

PubMed

Finkenzeller, T; Müller, E; Amesberger, G

2011-08-01

This study determined the effects of a skiing intervention lasting 12 weeks on the psycho-physiological reactivity to and recovery from mental stressors in individuals who are 60+ years of age. In accordance with the cross-stressor hypothesis, it was assumed that a skiing intervention optimizes psycho-physiological pre-conditions for coping with stress. A cognitive task was used to investigate stress-induced changes (reactivity) in the high-frequency (HF) component of the heart rate variability (HRV) and in the skin conductance level (SCL) as well as recovery from this stressor. The intervention group demonstrated a significant increase in maximal oxygen consumption that was not accompanied by alterations in HRV at rest. In comparison with the control group, there was no difference in the alteration of the reactivity and recovery in the HF component and in the SCL after completing the training. The findings indicate that neither the psycho-physiological reactivity nor the recovery was influenced by the skiing intervention. It may be speculated that the intensity of the skiing intervention was too low to induce such adaptations. Therefore, further studies are encouraged to enhance the duration and intensity of the exercises to achieve adaptations of the autonomous nervous system of elderly individuals. © 2011 John Wiley & Sons A/S.

Alpine Skiing With total knee ArthroPlasty (ASWAP): metabolism, inflammation, and skeletal muscle fiber characteristics.

PubMed

Kristensen, M; Pötzelsberger, B; Scheiber, P; Bergdahl, A; Hansen, C N; Andersen, J L; Narici, M; Salvioli, S; Conte, M; Müller, E; Dela, F

2015-08-01

We investigated the effect of alpine skiing for 12 weeks on skeletal muscle characteristics and biomarkers of glucose homeostasis and cardiovascular risk factors. Twenty-three patients with a total knee arthroplasty (TKA) were studied 2.9 ± 0.9 years (mean ± SD) after the operation. Fourteen patients participated in the intervention group (IG) and nine in the control group (CG). Blood samples and muscle biopsies were obtained before (PRE) and 7.3 ± 0.8 days after (POST) the intervention, and blood samples again after a retention (RET) phase of 8 weeks. With skiing, glucose homeostasis improved in IG (decrease in fasting insulin, increase in muscle glycogen) but not in CG. Fiber type distribution and size, as well as capillary density and number of capillaries around the fibers (CAF), were not different between the operated and the non-operated leg in either group. The relative number of type I fibers increased with skiing in IG with no change in CG. Inflammatory biomarkers, plasma lipids, and mitochondrial proteins and activity did not change. Alpine skiing is metabolically beneficial and can be used as a training modality by elderly people with TKA. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Effects of an Alpine Ski Resort on Hydrology and Water Quality in the Northeastern U.S.: Preliminary Findings from a Field Study

NASA Astrophysics Data System (ADS)

Wemple, B.; Shanley, J.; Denner, J.

2002-12-01

High elevation, forested watersheds are particularly vulnerable to stresses from development. Steep slopes and thin soils rapidly transmit water, nutrients and sediment when disturbed by logging, road construction or other activities associated with development. The effects of forest harvesting practices on streamflow and water quality in high-elevation, forested watersheds have been well studied and provide relevant information about the susceptibility of these ecosystems to anthropogenic disturbance. Few studies have directly addressed the hydrologic or water quality effects of ski resort development on mountain streams, and these studies draw almost entirely from western U.S. examples. Ski resorts in the eastern U.S. face particular development pressures. Transient and unpredictable snow conditions generate extensive need for snowmaking. Competitive economic pressure has motivated plans for slope-side village development and summer recreation facilities at many eastern U.S. ski resorts. Here, we report preliminary findings of a recently initiated paired-watershed study to examine the effects of alpine ski area development on water quantity and quality. Our study area is located on the eastern slope of Mt. Mansfield, Vermont, and includes the basins of Ranch Brook (9.6 sq km) and West Branch (11.7 sq km). Ranch Brook is undeveloped, except for a network of cross-country ski trails and unsurfaced access roads, and serves as our control watershed. West Branch encompasses nearly an entire major ski resort, with an extensive network of alpine ski lifts and trails, day lodges, snowmaking facilities, and vacation homes. A major expansion of resort facilities and ski trails has recently received state approval. Our preliminary analysis indicates distinct differences in runoff and water quality between the two basins. Differences in basin hydrographs suggest that ski trails alter the timing and magnitude of runoff, particularly during spring snowmelt. Elevated

Bridging East and West--Or, a Bridge Too Far? Paulo Freire and the "Tao Te Ching"

ERIC Educational Resources Information Center

Roberts, Peter

2012-01-01

This article considers key differences and similarities between Freirean and Taoist ideals. I limit my focus to the "Tao Te Ching" (attributed to Lao Tzu), paying brief attention to the origins of this classic work of Chinese philosophy before concentrating on several themes of relevance to Freire's work. An essay by James Fraser (1997), who makes…

[Head injuries in childhood caused by skiing and their optimal prevention].

PubMed

Oh, S; Schmid, U D

1983-04-01

During the last three skiing seasons we have treated a total of 105 children in our clinical wards for skull-brain injuries caused by skiing accidents. 25 of these cases (25.2%) were operated on, mostly because of a depressed fracture (92%) with or without brain lesion/bleeding, which the children incurred by colliding with various obstacles. Uncontrolled excessive speed and careless skiing methods are the main reasons for these injuries. However, the responsibility for the increasing number of skisport-connected skull-brain injuries does not lie with the children alone, but more so with us grown-ups, i.e. the parents, teachers and physicians, as long as we do not preach and emphatically insist on the implementation of indirect and direct specific measures of accident prevention. Based on an analysis of typical injuries and their many causes we come to the conclusion that, aside from the usual precautions, only one simple, sensible and effective prevention of skull-brain injuries is feasible, namely the "protection helmet". Similar to the existing crash-helmet law for motorcylists and just like for the professional skiracers, whom the children try to imitate more and more with regard to style and speed, we earnestly urge legislation to make the wearing of a protective helmet compulsory for all skiers up to 17 years of age.

Erosion Processes, Sediment Transport and Hydrological Responses Due to Land Use Changes in Serbian Ski Resorts

NASA Astrophysics Data System (ADS)

Ristic, R.; Radic, B.; Vasiljevic, N.; Nikic, Z.; Malusevic, I.

2012-04-01

The construction or improvement of Serbian ski resorts provoked intensive erosion processes, sediment transport and hydrological responses due to land use changes, affecting the surrounding environment and even endangering the functionality of the built objects. The dominant disturbing activities (clear cuttings, trunk transport, machine grading of slopes, huge excavations, and access road construction) were followed by the activities during skiing and non skiing periods (skiing, usage of snow groomers, moving of vehicles and tourists, forestry activities and overgrazing). These activities put a lot of pressure on the environment, including the removal or compaction of the surface soil layer, the reduction of the infiltration capacity, the destruction or degradation of the vegetation cover, the intensifying of the surface runoff and the development of erosion processes. The most affected ski runs were surveyed (scale 1:1000) and all damages were mapped and classified during the summers of 2007-2010. The development of rills and gullies was measured at experimental plots (100x60 m), and the survey data were entered into a GIS application. The area sediment yield and the intensity of erosion processes were estimated on the basis of the "Erosion Potential Method"(EPM). The changes in hydrological conditions were estimated by comparing the computed values of maximal discharges in the conditions before and after massive activities in the ski resorts, as well as by using the local hydrological records. The determination of maximal discharges was achieved using a combined method: the synthetic unit hydrograph (maximum ordinate of unit runoff, qmax) and the Soil Conservation Service (SCS, 1979) methodology (deriving effective rainfall, Pe, from total precipitation, Pb). The determination was performed for AMC III (Antecedent Moisture Conditions III: high water content in the soil and significantly reduced infiltration capacity). The computations of maximal discharges were

Paleomagnetism and Tectonic Interpretations of the Taos Plateau Volcanic Field, Rio Grande Rift, New Mexico

NASA Technical Reports Server (NTRS)

Brown, Laurie L.; Caffall, Nancy M.; Golombek, Matthew P.

1993-01-01

The tectonic response of the Taos Plateau volcanic field in the southern San Luis basin to the late stage extensional environment of the Rio Grande rift was investigated using paleomagnetic techniques. Sixty-two sites (533 samples) of Pliocene volcanic units were collected covering four major rock types with ages of 4.7 to 1.8 Ma. Twenty-two of these sites were from stratigraphic sections of the lower, middle and upper Servilleta Basalt collected in the Rio Grande gorge at two locations 19 km apart. Flows from the lower and middle members in the southern gorge record reversed polarities, while those in Garapata Canyon are normal with an excursion event in the middle of the sequence. The uppermost flows of the upper member at both sites display normal directions. Although these sections correlate chemically, they seem to represent different magnetic time periods during the Gilbert Reversed-Polarity Chiron. Alternating field demagnetization, aided by principal component analysis, yields 55 sites with stable directions representing both normal and reversed polarities, and five sites indicating transitional fields. Mean direction of the normal and inverted reversed sites is I=49.3 deg. and D=356.7 deg. (alpha(sub 95)=3.6 deg). Angular dispersion of the virtual geomagnetic poles is 16.3 deg, which is consistent with paleosecular variation model G, fit to data from the past 5 m.y. Comparison with the expected direction indicates no azimuthal rotation of the Taos Plateau volcanic field; inclination flattening for the southern part of the plateau is 8.3 deg +/- 5.3 deg. Previous paleomagnelic data indicate 10 deg- 15 deg counterclockwise rotation of die Espanola block to the south over the past 5 m.y. The data suggest the Taos Plateau volcanic field, showing no rotation and some flattening in the south and east, has acted as a stable buttress and has been downwarped by overriding of the southeastern end of the plateau by the Picuris Mountains, which make up the northern

Technical snow production in skiing areas: conditions, practice, monitoring and modelling. A case study in Mayrhofen/Austria

NASA Astrophysics Data System (ADS)

Strasser, Ulrich; Hanzer, Florian; Marke, Thomas; Rothleitner, Michael

2017-04-01

The production of technical snow today is a self-evident feature of modern alpine skiing resort management. Millions of Euros are invested every year for the technical infrastructure and its operation to produce a homogeneous and continuing snow cover on the skiing slopes for the winter season in almost every larger destination in the Alps. In Austria, skiing tourism is a significant factor of the national economic structure. We present the framing conditions of technical snow production in the mid-size skiing resort of Mayrhofen (Zillertal Alps/Austria, 136 km slopes, elevation range 630 - 2.500 m a.s.l.). Production conditions are defined by the availability of water, the planned date for the season opening, and the climatic conditions in the weeks before. By means of an adapted snow production strategy an attempt is made to ecologically and economically optimize the use of water and energy resources. Monitoring of the snow cover is supported by a network of low-cost sensors and mobile snow depth recordings. Finally, technical snow production is simulated with the spatially distributed, physically based hydroclimatological model AMUNDSEN. The model explicitly considers individual snow guns and distributes the produced snow along the slopes. The amount of simulated snow produced by each device is a function of its type, of actual wet-bulb temperature at the location, of ski area infrastructure (in terms of water supply and pumping capacity), and of snow demand.

HSP-70 mitigates LPS/SKI-induced cell damage by increasing sphingosine kinase 1 (SK1).

PubMed

Ding, Xuan Z; Feng, Xiao R; Borschel, Richard H; Nikolich, Mikeljon P; Feng, Jie; Li, Yan S; Hoover, David L

2010-06-01

Heat shock proteins (HSPs) are potent protectors of cellular integrity against environmental stresses, including toxic microbial products. To investigate the mechanism of HSP-70 cell protection against bacterial lipopolysaccharide (LPS), we established a stable HSP-70 gene-transfected RAW 264.7 murine macrophage model of LPS-induced cell death. Bacterial LPS increases the activity of sphingosine kinase 1 (SK1), which catalyzes formation of sphingosine-1-phosphate (S1P). S1P functions as a critical signal for initiation and maintenance of diverse aspects of immune cell activation and function. When mouse macrophages were incubated with Escherichia coli LPS (1 microg/ml) and sphingosine kinase inhibitor (SKI, 5 microM), 90% of cells died. Neither LPS nor SKI alone at these doses damaged the cells. The LPS/SKI-induced cell death was partially reversed by overexpression of HSP-70 in gene-transfected macrophages. The specificity of HSP-70 in this reversal was demonstrated by transfection of HSP-70-specific siRNA. Down-regulation of HSP-70 expression after transfection of siRNA specific for HSP-70 was associated with increased LPS/SKI-induced cell damage. Overexpression of human or murine HSP-70 (HSPA1A and Hspa1a, respectively) increased both cellular SK1 mRNA and protein levels. Cellular heat shock also increased SK1 protein. These studies confirm the importance of SK1 as a protective moiety in LPS-induced cell injury and demonstrate that HSP-70-mediated protection from cells treated with LPS/SKI is accompanied by upregulating expression of SK1. HSP-70-mediated increases in SK1 and consequent increased levels of S1P may also play a role in protection of cells from other processes that lead to programmed cell death. Published by Elsevier Inc.

How Do World-Class Nordic Combined Athletes Differ From Specialized Cross-Country Skiers and Ski Jumpers in Sport-Specific Capacity and Training Characteristics?

PubMed

Sandbakk, Øyvind; Rasdal, Vegard; Bråten, Steinar; Moen, Frode; Ettema, Gertjan

2016-10-01

To compare sport-specific laboratory capacities and the annual training of world-class Nordic combined (NC) athletes with specialized ski jumpers (SJ) and cross-country (XC) skiers. Five world-class athletes from each sports discipline were compared. Ski jump imitations were performed on a 3-dimensional force plate in NC athletes and SJ, whereas XC skiing characteristics were obtained from submaximal and maximal roller ski skating on a treadmill in NC athletes and XC skiers. In addition, anthropometrics and annual training characteristics were determined. NC athletes demonstrated 9% higher body mass and showed 17% lower vertical speed in the ski jump imitation than SJ (all P < .05). NC athletes had 12% lower body mass and showed 10% lower peak treadmill speed and 12% lower body-mass-normalized peak oxygen uptake than XC skiers (all P < .05). NC athletes performed half the number of ski-jumping-specific sessions and outdoor ski jumps compared with SJ. NC athletes performed 31% less endurance training, mainly caused by lower amounts of low- and moderate-intensity training in the classical technique, whereas high-intensity strength and speed training and endurance training in the skating technique did not differ substantially from XC skiers. To simultaneously optimize endurance, explosive, and technical capacities in 2 different disciplines, world-class NC athletes train approximately two-thirds of the XC skier's endurance training volume and perform one-half of the ski-jump-specific training compared with SJ. Still, the various laboratory capacities differed only 10-17% compared with SJ and XC skiers.

[Analysis on professor WANG Juyi's crevice theory from Tao Teh King].

PubMed

Luo, Lu; Wang, Juyi

2015-10-01

The crevice theory proposed by professor WANG Juyi is analyzed in this article. In the crevice theory, it is believed that the meridians are located among "skin, pulse, flesh, tendon and bone", and the crevice is the path for the transportation of qi-blood and body fluid in the body, which is the essential condition for vital movement. This is in agreement with the idea of "action through inaction" from Tao Teh King. Based on crevice theory, the abnormalities of meridians can reflex the deficiency and excess of diseases, and regulating meridians is a significant way to treat diseases, and maintaining smooth meridian is important for healthcare.

The effects of the arm swing on biomechanical and physiological aspects of roller ski skating.

PubMed

Hegge, Ann Magdalen; Ettema, Gertjan; de Koning, Jos J; Rognstad, Asgeir Bakken; Hoset, Martin; Sandbakk, Øyvind

2014-08-01

This study analyzed the biomechanical and physiological effects of the arm swing in roller ski skating, and compared leg-skating (i.e. ski skating without poles) using a pronounced arm swing (SWING) with leg-skating using locked arms (LOCKED). Sixteen elite male cross-country skiers performed submaximal stages at 10, 15 and 20kmh(-1) on a 2% inclined treadmill in the two techniques. SWING demonstrated higher peak push-off forces and a higher force impulse at all speeds, but a longer cycle length only at the highest speed (all P<.05), indicating a lower force effectiveness with SWING at the two lowest speeds. Additionally, the flexion-extension movement in the lower limbs was more pronounced for SWING. Oxygen uptake was higher for SWING at the two lowest speeds (both P<.05) without any differences in blood lactate. At the highest speed, oxygen uptake did not differ between SWING and LOCKED, but the RER, blood lactate and ventilation were lower with SWING (all P<.05). Taken together, these results demonstrate that utilizing the arm swing in roller ski skating increases the ski forces and aerobic energy cost at low and moderate speeds, whereas the greater forces at high speed lead to a longer cycle length and smaller anaerobic contribution. Copyright © 2014 Elsevier B.V. All rights reserved.

A Validation of the Ski Hi Language Development Scale.

ERIC Educational Resources Information Center

Tonelson, Stephen W.

The purpose of the study was to assess the reliability and the validity of the Ski Hi Language Development Scale which was designed to determine the receptive and the expressive language levels of hearing impaired children from birth to age 5. The reliability of the instrument was estimated through: (1) internal consistency, (2) inter-rater…

Skier and Snowboarder Motivations and Knowledge Related to Voluntary Environmental Programs at an Alpine Ski Area

NASA Astrophysics Data System (ADS)

Little, Christopher M.; Needham, Mark D.

2011-11-01

Many alpine ski areas have recently adopted voluntary environmental programs (VEPs) such as using recycling, renewable energy, and biofuels to help reduce their environmental impacts. Studies have addressed the performance of these VEPs in mitigating environmental impacts of this industry, but little is known about visitor awareness and perceptions of these programs. This article addresses this knowledge gap by exploring skier and snowboarder knowledge of VEPs at a ski area and the influence of these programs on their motivations to visit this area currently and behavioral intentions to visit again in the future. Data were obtained from an onsite survey at the Mt. Bachelor ski area in Oregon, USA ( n = 429, 89.7% response rate). Few skiers and snowboarders were knowledgeable of VEPs at this area and fewer than 20% were motivated to visit on their current trip because of these programs. Other attributes such as scenery, snow conditions, and access were more important for influencing visitation. Up to 38% of skiers and snowboarders, however, intend to visit this ski area more often if it adopts and promotes more VEPs. Managers can use these results to inform communication and marketing of their environmental programs and performance to visitors. Additional implications for management and future research are discussed.

Skier and snowboarder motivations and knowledge related to voluntary environmental programs at an alpine ski area.

PubMed

Little, Christopher M; Needham, Mark D

2011-11-01

Many alpine ski areas have recently adopted voluntary environmental programs (VEPs) such as using recycling, renewable energy, and biofuels to help reduce their environmental impacts. Studies have addressed the performance of these VEPs in mitigating environmental impacts of this industry, but little is known about visitor awareness and perceptions of these programs. This article addresses this knowledge gap by exploring skier and snowboarder knowledge of VEPs at a ski area and the influence of these programs on their motivations to visit this area currently and behavioral intentions to visit again in the future. Data were obtained from an onsite survey at the Mt. Bachelor ski area in Oregon, USA (n = 429, 89.7% response rate). Few skiers and snowboarders were knowledgeable of VEPs at this area and fewer than 20% were motivated to visit on their current trip because of these programs. Other attributes such as scenery, snow conditions, and access were more important for influencing visitation. Up to 38% of skiers and snowboarders, however, intend to visit this ski area more often if it adopts and promotes more VEPs. Managers can use these results to inform communication and marketing of their environmental programs and performance to visitors. Additional implications for management and future research are discussed.

Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma.

PubMed

Fukuchi, Minoru; Nakajima, Masanobu; Fukai, Yasuyuki; Miyazaki, Tatsuya; Masuda, Norihiro; Sohda, Makoto; Manda, Ryokuhei; Tsukada, Katsuhiko; Kato, Hiroyuki; Kuwano, Hiroyuki

2004-03-01

Transforming growth factor-beta (TGF-beta) regulates cell growth inhibition, and inactivation of the TGF-beta signaling pathway contributes to tumor development. In our previous study, altered expression of TGF-beta, TGF-beta-specific receptors and Smad4 was shown to correlate with tumor progression in esophageal squamous cell carcinoma (SCC). These components, however, were maintained normally in some patients with esophageal SCC. In our study, the mechanism by which aggressive esophageal SCC maintains these components was investigated, with particular emphasis on the participation of c-Ski and SnoN as transcriptional co-repressors in TGF-beta signaling. Immunohistochemistry for c-Ski and SnoN was carried out on surgical specimens obtained from 80 patients with esophageal SCC. The expression of c-Ski and SnoN was also studied in 6 established cell lines derived from esophageal SCC and compared to an immortalized human esophageal cell line by Western blotting. High levels of expression of c-Ski, detected immunohistologically, were found to correlate with depth of invasion (p = 0.0080) and pathologic stage (p = 0.0447). There was, however, no significant correlation between expression of SnoN and clinicopathologic characteristics. A significant correlation between c-Ski and TGF-beta expression was observed. Moreover, in patients with TGF-beta negative expression, the survival rates of patients with c-Ski positive expression were significantly lower than those of patients with c-Ski negative expression (p = 0.0486). c-Ski was expressed at a high level in 5 of 6 cell lines derived from esophageal SCC compared to immortalized esophageal keratinocytes. Furthermore, the cyclin-dependent kinase (CDK) inhibitor, p21 that was up-regulated by TGF-beta signaling was expressed at a low level in the 5 cell lines. The expression of c-Ski protein as a transcriptional co-repressor in TGF-beta signaling seems to be correlated with tumor progression of esophageal SCC. Copyright 2003

Paleomagnetism and tectonic interpretations of the Taos Plateau volcanic field, Rio Grande rift, New Mexico

NASA Technical Reports Server (NTRS)

Brown, Laurie L.; Caffall, Nancy M.; Golombek, Matthew P.

1993-01-01

The tectonic response of the Taos Plateau volcanic field in the southern San Luis basin to late stage extensional environment of the Rio Grande rift was investigate using paleomagnetic techniques. Sixty-two sites (533 samples) of Pliocene volcanic units were collected covering four major rock types with ages of 4.7 to 1.8 Ma. Twenty-two of these sites were from stratigraphic sections of the lower, middle and upper Servilleta Basalt collected in the Rio Grande gorge at two locations 19 km apart. Flows from the lower and middle members in the southern gorge record reversed polarities, while those in Garapata Canyon are normal with an excursion event in the middle of the sequence. The uppermost flows of the upper member at both sites display normal directions. Although these sections correlate chemically, they seem to represent different magnetic time periods during the Gilbert Reversed-Polarity Chron. The data suggest the Taos Plateau volcanic field, showing no rotation and some flattening in the south and east, has acted as a stable buttress and has been downwarped by overriding of the southeastern end of the plateau by the Picuris Mountains, which make up the northern corner of the counter-clockwise rotating Espanola block.

Paleomagnetism and tectonic interpretations of the Taos Plateau volcanic field, Rio Grande rift, New Mexico

NASA Astrophysics Data System (ADS)

Brown, Laurie L.; Caffall, Nancy M.; Golombek, Matthew P.

1993-12-01

The tectonic response of the Taos Plateau volcanic field in the southern San Luis basin to late stage extensional environment of the Rio Grande rift was investigate using paleomagnetic techniques. Sixty-two sites (533 samples) of Pliocene volcanic units were collected covering four major rock types with ages of 4.7 to 1.8 Ma. Twenty-two of these sites were from stratigraphic sections of the lower, middle and upper Servilleta Basalt collected in the Rio Grande gorge at two locations 19 km apart. Flows from the lower and middle members in the southern gorge record reversed polarities, while those in Garapata Canyon are normal with an excursion event in the middle of the sequence. The uppermost flows of the upper member at both sites display normal directions. Although these sections correlate chemically, they seem to represent different magnetic time periods during the Gilbert Reversed-Polarity Chron. The data suggest the Taos Plateau volcanic field, showing no rotation and some flattening in the south and east, has acted as a stable buttress and has been downwarped by overriding of the southeastern end of the plateau by the Picuris Mountains, which make up the northern corner of the counter-clockwise rotating Espanola block.

Effects of electroacupuncture and electroacupuncture plus Tao Hong Si Wu Wan in treating primary dysmenorrhea.

PubMed

Miao, Edwin Yong; Miao, Miranda Yi-mo; Kildea, Daniel George; Lao, Yi-Wen

2014-02-01

This study investigated the efficacies of electroacupuncture and electroacupuncture combined with Tao Hong Si Wu Wan in treating primary dysmenorrhea and compared the results with those obtained using conventional medical treatment. One treatment group, group 1, was administered Tao Hong Si Wu Wan (2625 mg) while the other, group 2, was administered a placebo (2625 mg) twice daily for 3 months. Electroacupuncture was used in both treatment groups: two sessions per menstrual cycle for three menstrual cycles. The reference group, group 3, was administered ibuprofen, 600 mg, twice daily, for five menstrual cycles. Uses of the herb, placebo and ibuprofen were blinded. A ridit analysis was used for testing and interpreting the effects of treatment. Pain intensity was determined using a qualitative grading method in a blinded manner. The ridit scores in groups 1 and 2 were significantly higher than those in reference group immediately after treatment and three months later. Twelve months after the treatment, group 1 had a higher ridit score than group 2. In comparison to the reference group, groups 1 and 2 achieved better menstrual pain relief both immediately and 3 months after treatment. In addition, group 1 had better long-term pain relief than group 2. Copyright © 2014. Published by Elsevier B.V.

How Hinge Positioning in Cross-Country Ski Bindings Affect Exercise Efficiency, Cycle Characteristics and Muscle Coordination during Submaximal Roller Skiing

PubMed Central

Bolger, Conor M.; Sandbakk, Øyvind; Ettema, Gertjan; Federolf, Peter

2016-01-01

The purposes of the current study were to 1) test if the hinge position in the binding of skating skis has an effect on gross efficiency or cycle characteristics and 2) investigate whether hinge positioning affects synergistic components of the muscle activation in six lower leg muscles. Eleven male skiers performed three 4-min sessions at moderate intensity while cross-country ski-skating and using a klapskate binding. Three different positions were tested for the binding’s hinge, ranging from the front of the first distal phalange to the metatarsal-phalangeal joint. Gross efficiency and cycle characteristics were determined, and the electromyographic (EMG) signals of six lower limb muscles were collected. EMG signals were wavelet transformed, normalized, joined into a multi-dimensional vector, and submitted to a principle component analysis (PCA). Our results did not reveal any changes to gross efficiency or cycle characteristics when altering the hinge position. However, our EMG analysis found small but significant effects of hinge positioning on muscle coordinative patterns (P < 0.05). The changed patterns in muscle activation are in alignment with previously described mechanisms that explain the effects of hinge positioning in speed-skating klapskates. Finally, the within-subject results of the EMG analysis suggested that in addition to the between-subject effects, further forms of muscle coordination patterns appear to be employed by some, but not all participants. PMID:27203597

Expert - Non-expert differences in visual behaviour during alpine slalom skiing.

PubMed

Decroix, Marjolein; Wazir, Mohd Rozilee Wazir Norjali; Zeuwts, Linus; Deconinck, Frederik F J A; Lenoir, Matthieu; Vansteenkiste, Pieter

2017-10-01

The aim of this study was to investigate visual behaviour of expert and non-expert ski athletes during an alpine slalom. Fourteen non-experts and five expert slalom skiers completed an alpine slalom course in an indoor ski slope while wearing a head-mounted eye tracking device. Experts completed the slalom clearly faster than non-experts, but no significant difference was found in timing and position of the turn initiation. Although both groups already looked at future obstacles approximately 0,5s before passing the upcoming pole, the higher speed of experts implied that they shifted gaze spatially earlier in the bend than non-experts. Furthermore, experts focussed more on the second next pole while non-expert slalom skiers looked more to the snow surface immediately in front of their body. No difference was found in the fixation frequency, average fixation duration, and quiet eye duration between both groups. These results suggest that experts focus on the timing of their actions while non-experts still need to pay attention to the execution of these actions. These results also might suggest that ski trainers should instruct non-experts and experts to focus on the next pole and, shift their gaze to the second next pole shortly before reaching it. Based on the current study it seems unadvisable to instruct slalom skiers to look several poles ahead during the actual slalom. However, future research should test if these results still hold on a real outdoor slope, including multiple vertical gates. Copyright © 2017 Elsevier B.V. All rights reserved.

No Snow? No Problem! Ski Statutes Still Provide Legal Protection

ERIC Educational Resources Information Center

Buckmaster, Melanie E.; Young, Sarah J.

2018-01-01

In August 2012, Barbara Fakhouri visited Ober Gatlinburg, a ski resort located in eastern Tennessee to vacation with her family. Ms. Fakhouri used a wheelchair to ambulate. Despite the absence of snow on the ground, the resort operated year-round with many amenities such as an amusement park, restaurant, lounge, and shopping center to captivate…

Arsenic Removal from Drinking Water by Adsorptive Media - U.S. EPA Demonstration Project at Taos, NM, Final Performance Evaluation Report

EPA Science Inventory

This report documents the activities performed and the results obtained for the EPA arsenic removal technology demonstration project at the Town of Taos in New Mexico. The main objective of the project was to evaluate the effectiveness of Severn Trent Services’ (STS) SORB 33™ ad...

Spatial Analysis of the Effects of the Anomalous Winter of 2014/15 on 157 Ski Resorts Located in Western North America

NASA Astrophysics Data System (ADS)

Bahbahani, K. M.; Pidwirny, M. J.

2017-12-01

The winter of 2014/2015 was one of the warmest in recent history for many locations in western North America. The cause of this climate irregularity was the development of extremely warm ocean surface waters (The Blob) over much of the eastern North Pacific Ocean. During this winter season, many ski resorts in western Canada and the United States either did not open or were forced to close their ski season early. Here, we examine climate data from 157 ski resorts to develop a picture of where the effected locations were in western North America. Using the climate database software ClimateBC and ClimateNA, high quality downscaled historical data was generated for the winter season (December, January, and February) for the variables mean temperature, snowfall, and rainfall. Values for winter of 2014/15 were statistically compared to the 30-year normal period from 1981-2010. Z-scores were calculated for 2014/15 relative to the selected 30-year normal period. These Z-score values were then mapped using ArcGIS. From the mean winter temperature map, it is apparent that abnormally warm temperatures influenced many ski resorts in California, Nevada, western Oregon, Washington, Arizona, Utah, southern Idaho, and parts of southern British Columbia. The winter snowfall map shows anomalous below normal conditions only at two resorts in south-central British Columbia and a single above normal situation at one site in central Colorado. The winter rainfall map displays that many ski resorts in New Mexico, Arizona, southern Utah, Colorado, Wyoming, Montana, Idaho, western Washington, and southwestern British Columbia experienced exceptional above normal winter season rainfalls. It is highly likely that the next Blob will be forecasted many months in advance of its occurrence. The results of this study have identified which ski resorts could be climatically influenced by such an event. This information may help reduce potential financial losses to ski resorts and their associated

Demographics of alpine skiing and snowboarding injury: lessons for prevention programs.

PubMed Central

Macnab, A. J.; Cadman, R.

1996-01-01

OBJECTIVE: To establish the demographics of ski injury in relation to age, gender, and perceived cause during a representative season to identify potential injury prevention strategies. SETTING: Blackcomb Mountain, a world class ski resort in British Columbia, Canada. METHODS: Data were collected from the lift ticket records and from ski patrol injury reports for one season, November to May 1991-2. RESULTS: There were 720,066 skier and snowboarder day visits counted by the mountain's lift ticket records, with a total of 2,092 injury reports (incidence 2.91 per 1,000 day visits). Of those with significant injuries (those requiring physician care), 1,210 (58%) were male. The highest injury rate was among children (age 7-12) and teens (age 13-17) with incidences of 3.18 and 3.34 significant injuries per 1,000 skier days, respectively. Head and face injuries constituted 17% and 22% of injuries, respectively in these groups. Overall 22% of head and face injuries were severe enough to cause loss of consciousness or clinical signs of concussion. This was the body region injured most frequently in males. For females over 7 years of age, the knee was the most common site of injury. For youths, the incidence of injuries during school organized activities was 25% higher than during other outings. CONCLUSIONS: The vulnerability of school group participants suggests special education is warranted. The high incidence of head injuries, particularly among young males, needs to be addressed. In light of the high proportion of this group who already wear helmets, the role of helmets in both protection and possible causation of head injury needs objective research. Images PMID:9346110

Effect of ski simulator training on kinematic and muscle activation of the lower extremities

PubMed Central

Moon, Jeheon; Koo, Dohoon; Kim, Kitae; Shin, Insik; Kim, Hyeyoung; Kim, Jinhae

2015-01-01

[Purpose] This study aimed to verify the effectiveness of an augmented reality-based ski simulator through analyzing the changes in movement patterns as well as the engagement of major muscles of the lower body. [Subjects] Seven subjects participated in the study. All were national team-level athletes studying at “K” Sports University in Korea who exhibited comparable performance levels and had no record of injuries in the preceding 6 months (Age 23.4 ± 3.8 years; Height 172.6 ± 12.1 cm; Weight 72.3 ± 16.2 kg; Experience 12.3 ± 4.8 years). [Methods] A reality-based ski simulator developed by a Korean manufacturer was used for the study. Three digital video cameras and a wireless electromyography system were used to perform 3-dimensional motion analysis and measure muscle activation level. [Results] Left hip angulation was found to increase as the frequency of the turns increased. Electromyography data revealed that the activation level of the quadriceps group’s extension muscles and the biceps femoris group’s flexing muscles had a crossing pattern. [Conclusion] Sustained training using an augmented reality-based ski simulator resulted in movements that extended the lower body joints, which is thought to contribute to increasing muscle fatigue. PMID:26357449

Anaerobic threshold assessment through the ventilatory method during roller-ski skating testing: right or wrong?

PubMed

Fabre, Nicolas; Bortolan, Lorenzo; Pellegrini, Barbara; Zerbini, Livio; Mourot, Laurent; Schena, Federico

2012-02-01

This study aimed at questioning the validity of the ventilatory method to determine the anaerobic threshold (respiratory compensation point [RCP]) during an incremental roller-ski skating test to exhaustion. Nine elite crosscountry skiers were evaluated. The skiers carried out an incremental roller-ski test on a treadmill with the V2 skating technique. Ventilatory parameters were continuously collected breath by breath, thanks to a portable gas exchange measurement system. Poling signal was obtained using instrumented ski poles. For each stage, ventilatory and poling signals were synchronized and averaged. The poor coefficient of interobserver reliability for the time at RCP confirmed the great difficulty felt by the 3 blinded reviewers for the RCP determination. Moreover, the reviewer agreed with the impossibility of determining RCP in 4 of the 9 skiers. There was no significant difference between breathing frequency (Bf) and poling frequency (Pf) during the last 8 stages. However, it seems that the differences observed during the first stages arose from the use of either a strictly 1:1 or a 1:2 Bf to Pf ratio when the exercise intensity was still moderate. So, even if there were significant differences between the frequencies, the Bf was strictly subordinate to the Pf during the entire test. In the same way, the normalized tidal volume and peak poling forces curves were superposable. These findings showed that when the upper body is mainly involved in the propulsion, the determinants of the ventilation are strictly dependent on the poling pattern during an incremental test to exhaustion. Thus, during roller-ski skating, the determination of RCP must be used cautiously because too much depending on mechanical factors.

Hydrological Responses of Climate and Land Use/Cover Changes in Tao'er River Basin Based on the SWAT Model

NASA Astrophysics Data System (ADS)

Liu, J.; Kou, L.

2015-12-01

Abstract: The changes of both climate and land use/cover have some impact on the water resources. For Tao'er River Basin, these changes have a direct impact on the land use pattern adjustment, wetland protection, connection project between rivers and reservoirs, local social and economic development, etc. Therefore, studying the impact of climate and land use/cover changes is of great practical significance. The Soil and Water Assessment Tool (SWAT) is used as the research method. With historical actual measured runoff data and the yearly land use classification caught by satellite remote sensing maps, analyze the impact of climate change on the runoff of Tao'er River. And according to the land use/cover classification of 1990, 2000 and 2010, analyze the land use/cover change in the recent 30 years, the impact of the land use/cover change on the river runoff and the contribution coefficient of farmland, woodland, grassland and other major land-use types to the runoff. These studies can provide some references to the rational allocation of water resource and adjustment of land use structure in this area.

Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN.

PubMed

Mizuide, Masafumi; Hara, Takane; Furuya, Toshio; Takeda, Masafumi; Kusanagi, Kiyoshi; Inada, Yuri; Mori, Masatomo; Imamura, Takeshi; Miyazawa, Keiji; Miyazono, Kohei

2003-01-03

c-Ski and SnoN are transcriptional co-repressors that inhibit transforming growth factor-beta signaling through interaction with Smad proteins. Among receptor-regulated Smads, c-Ski and SnoN bind more strongly to Smad2 and Smad3 than to Smad1. Here, we show that c-Ski and SnoN bind to the "SE" sequence in the C-terminal MH2 domain of Smad3, which is exposed on the N-terminal upper side of the toroidal structure of the MH2 oligomer. The "QPSMT" sequence, located in the vicinity of SE, supports the interaction with c-Ski and SnoN. Sequences similar to SE and QPSMT are found in Smad2, but not in Smad1. The N-terminal MH1 domain and linker region of Smad3 protrude from the N-terminal upper side of the MH2 oligomer toroid. Smurf2 induces ubiquitin-dependent degradation of SnoN, since it appears to be located close to SnoN through binding to the linker region of Smad2. In contrast, transcription factors Mixer and FoxH3 (FAST1) bind to the bottom side of the Smad3 MH2 toroid; therefore, c-Ski does not affect the interaction of Smads with these transcription factors. Our findings thus demonstrate the stoichiometry of how multiple molecules can associate with the Smad oligomers and how the Smad-interacting proteins functionally interact with each other.

Electronic Properties of Cyclacenes from TAO-DFT

PubMed Central

Wu, Chun-Shian; Lee, Pei-Yin; Chai, Jeng-Da

2016-01-01

Owing to the presence of strong static correlation effects, accurate prediction of the electronic properties (e.g., the singlet-triplet energy gaps, vertical ionization potentials, vertical electron affinities, fundamental gaps, symmetrized von Neumann entropy, active orbital occupation numbers, and real-space representation of active orbitals) of cyclacenes with n fused benzene rings (n = 4–100) has posed a great challenge to traditional electronic structure methods. To meet the challenge, we study these properties using our newly developed thermally-assisted-occupation density functional theory (TAO-DFT), a very efficient method for the study of large systems with strong static correlation effects. Besides, to examine the role of cyclic topology, the electronic properties of cyclacenes are also compared with those of acenes. Similar to acenes, the ground states of cyclacenes are singlets for all the cases studied. In contrast to acenes, the electronic properties of cyclacenes, however, exhibit oscillatory behavior (for n ≤ 30) in the approach to the corresponding properties of acenes with increasing number of benzene rings. On the basis of the calculated orbitals and their occupation numbers, the larger cyclacenes are shown to exhibit increasing polyradical character in their ground states, with the active orbitals being mainly localized at the peripheral carbon atoms. PMID:27853249

SKI2 mediates degradation of RISC 5'-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis.

PubMed

Branscheid, Anja; Marchais, Antonin; Schott, Gregory; Lange, Heike; Gagliardi, Dominique; Andersen, Stig Uggerhøj; Voinnet, Olivier; Brodersen, Peter

2015-12-15

Small regulatory RNAs are fundamental in eukaryotic and prokaryotic gene regulation. In plants, an important element of post-transcriptional control is effected by 20-24 nt microRNAs (miRNAs) and short interfering RNAs (siRNAs) bound to the ARGONAUTE1 (AGO1) protein in an RNA induced silencing complex (RISC). AGO1 may cleave target mRNAs with small RNA complementarity, but the fate of the resulting cleavage fragments remains incompletely understood. Here, we show that SKI2, SKI3 and SKI8, subunits of a cytoplasmic cofactor of the RNA exosome, are required for degradation of RISC 5', but not 3'-cleavage fragments in Arabidopsis. In the absence of SKI2 activity, many miRNA targets produce siRNAs via the RNA-dependent RNA polymerase 6 (RDR6) pathway. These siRNAs are low-abundant, and map close to the cleavage site. In most cases, siRNAs were produced 5' to the cleavage site, but several examples of 3'-spreading were also identified. These observations suggest that siRNAs do not simply derive from RDR6 action on stable 5'-cleavage fragments and hence that SKI2 has a direct role in limiting secondary siRNA production in addition to its function in mediating degradation of 5'-cleavage fragments. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Keeping an Uphill Edge: Managing Cleaning Behaviors at a Ski Shop

ERIC Educational Resources Information Center

Doll, Jessica; Livesey, Josh; McHaffie, Elizabeth; Ludwig, Timothy D.

2007-01-01

Several behaviors in a ski shop were identified as being deficient using Austin's Performance Diagnostic Checklist (2000) and Daniels and Daniels' PIC/NIC Analysis (2004). During a 4-week baseline, 7 cleaning behaviors were monitored and 5 were subsequently targeted in an intervention package using an ABC design. The intervention included: a task…

Intra-articular temperatures of the knee in sports – An in-vivo study of jogging and alpine skiing

PubMed Central

Becher, Christoph; Springer, Jan; Feil, Sven; Cerulli, Guiliano; Paessler, Hans H

2008-01-01

Background Up to date, no information exists about the intra-articular temperature changes of the knee related to activity and ambient temperature. Methods In 6 healthy males, a probe for intra-articular measurement was inserted into the notch of the right knee. Each subject was jogging on a treadmill in a closed room at 19°C room temperature and skiing in a ski resort at -3°C outside temperature for 60 minutes. In both conditions, temperatures were measured every fifteen minutes intra-articulary and at the skin surface of the knee. A possible influence on joint function and laxity was evaluated before and after activity. Statistical analysis of intra-articular and skin temperatures was done using nonparametric Wilcoxon's sign rank sum test and Mann-Whitney's-U-Test. Results Median intra-articular temperatures increased from 31.4°C before activity by 2.1°C, 4°C, 5.8°C and 6.1°C after 15, 30, 45 and 60 min of jogging (all p ≤ 0.05). Median intra-articular temperatures dropped from 32.2°C before activity by 0.5°C, 1.9°C, 3.6°C and 1.1°C after 15, 30, 45 and 60 min of skiing (all n.s.). After 60 minutes of skiing (jogging), the median intra-articular temperature was 19.6% (8.7%) higher than the skin surface temperature at the knee. Joint function and laxity appeared not to be different before and after activity within both groups. Conclusion This study demonstrates different changes of intra-articular and skin temperatures during sports in jogging and alpine skiing and suggests that changes are related to activity and ambient temperature. PMID:18405365

Safer Ski Jumps: Design of Landing Surfaces and Clothoidal In-Run Transitions

DTIC Science & Technology

2010-06-01

MINIMIZATION ......................................................................................... 9 B. DETERMINATION OF SKIER VELOCITY AT TAKEOFF...Spiral Flatness, Clothoid Length, and Angle From Horizontal ..................... 68 c. Free Body Diagram of a Skier in Clothoidal Transition...1 Figure 2. Ski jump in Einsiedeln, Switzerland, from [5] ................................................ 2 Figure 3. A skier performing

The effect of different oxygen exchange layers on TaO x based RRAM devices

NASA Astrophysics Data System (ADS)

Alamgir, Zahiruddin; Holt, Joshua; Beckmann, Karsten; Cady, Nathaniel C.

2018-01-01

In this work, we investigated the effect of the oxygen exchange layer (OEL) on the resistive switching properties of TaO x based memory cells. It was found that the forming voltage, SET-RESET voltage, R off, R on and retention properties are strongly correlated with the oxygen scavenging ability of the OEL, and the resulting oxygen vacancy formation ability of this layer. Higher forming voltage was observed for OELs having lower electronegativity/lower Gibbs free energy for oxide formation, and devices fabricated with these OELs exhibited an increased memory window, when using similar SET-RESET voltage range.

A power function profile of a ski jumping in-run hill.

PubMed

Zanevskyy, Ihor

2011-01-01

The aim of the research was to find a function of the curvilinear segment profile which could make possible to avoid an instantaneous increasing of a curvature and to replace a circle arc segment on the in-run of a ski jump without any correction of the angles of inclination and the length of the straight-line segments. The methods of analytical geometry and trigonometry were used to calculate an optimal in-run hill profile. There were two fundamental conditions of the model: smooth borders between a curvilinear segment and straight-line segments of an in-run hill and concave of the curvilinear segment. Within the framework of this model, the problem has been solved with a reasonable precision. Four functions of a curvilinear segment profile of the in-run hill were investigated: circle arc, inclined quadratic parabola, inclined cubic parabola, and power function. The application of a power function to the in-run profile satisfies equal conditions for replacing a circle arc segment. Geometrical parameters of 38 modern ski jumps were investigated using the methods proposed.

Demand-supply dynamics in tourism systems: A spatio-temporal GIS analysis. The Alberta ski industry case study

NASA Astrophysics Data System (ADS)

Bertazzon, Stefania

The present research focuses on the interaction of supply and demand of down-hill ski tourism in the province of Alberta. The main hypothesis is that the demand for skiing depends on the socio-economic and demographic characteristics of the population living in the province and outside it. A second, consequent hypothesis is that the development of ski resorts (supply) is a response to the demand for skiing. From the latter derives the hypothesis of a dynamic interaction between supply (ski resorts) and demand (skiers). Such interaction occurs in space, within a range determined by physical distance and the means available to overcome it. The above hypotheses implicitly define interactions that take place in space and evolve over time. The hypotheses are tested by temporal, spatial, and spatio-temporal regression models, using the best available data and the latest commercially available software. The main purpose of this research is to explore analytical techniques to model spatial, temporal, and spatio-temporal dynamics in the context of regional science. The completion of the present research has produced more significant contributions than was originally expected. Many of the unexpected contributions resulted from theoretical and applied needs arising from the application of spatial regression models. Spatial regression models are a new and largely under-applied technique. The models are fairly complex and a considerable amount of preparatory work is needed, prior to their specification and estimation. Most of this work is specific to the field of application. The originality of the solutions devised is increased by the lack of applications in the field of tourism. The scarcity of applications in other fields adds to their value for other applications. The estimation of spatio-temporal models has been only partially attained in the present research. This apparent limitation is due to the novelty and complexity of the analytical methods applied. This opens new

A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease

PubMed Central

Moncayo, Roy; Moncayo, Helga

2007-01-01

Background Low level connective tissue inflammation has been proposed to play a role in thyroid associated ophthalmopathy (TAO). The aim of this study was to investigate this postulate by a musculoskeletal approach together with biochemical parameters. Methods 13 patients with TAO and 16 controls were examined. Erythrocyte levels of Zn, Cu, Ca2+, Mg, and Fe were determined. The musculoskeletal evaluation included observational data on body posture with emphasis on the orbit-head region. The angular foot position in the frontal plane was quantified following gait observation. The axial orientation of the legs and feet was evaluated in an unloaded supine position. Functional propioceptive tests based on stretch stimuli were done by using foot inversion and foot rotation. Results Alterations in the control group included neck tilt in 3 cases, asymmetrical foot angle during gait in 2, and a reaction to foot inversion in 5 cases. TAO patients presented facial asymmetry with displaced eye fissure inclination (mean 9.1°) as well as tilted head-on-neck position (mean 5.7°). A further asymmetry feature was external rotation of the legs and feet (mean 27°). Both foot inversion as well as foot rotation induced a condition of neuromuscular deficit. This condition could be regulated by gentle acupressure either on the lateral abdomen or the lateral ankle at the acupuncture points gall bladder 26 or bladder 62, respectively. In 5 patients, foot rotation produced a phenomenon of moving toes in the contra lateral foot. In addition foot rotation was accompanied by an audible tendon snapping. Lower erythrocyte Zn levels and altered correlations between Ca2+, Mg, and Fe were found in TAO. Conclusion This whole body observational study has revealed axial deviations and body asymmetry as well as the phenomenon of moving toes in TAO. The most common finding was an arch-like displacement of the body, i.e. eccentric position, with foot inversion and head tilt to the contra lateral side

SKI2 mediates degradation of RISC 5′-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis

PubMed Central

Branscheid, Anja; Marchais, Antonin; Schott, Gregory; Lange, Heike; Gagliardi, Dominique; Andersen, Stig Uggerhøj; Voinnet, Olivier; Brodersen, Peter

2015-01-01

Small regulatory RNAs are fundamental in eukaryotic and prokaryotic gene regulation. In plants, an important element of post-transcriptional control is effected by 20–24 nt microRNAs (miRNAs) and short interfering RNAs (siRNAs) bound to the ARGONAUTE1 (AGO1) protein in an RNA induced silencing complex (RISC). AGO1 may cleave target mRNAs with small RNA complementarity, but the fate of the resulting cleavage fragments remains incompletely understood. Here, we show that SKI2, SKI3 and SKI8, subunits of a cytoplasmic cofactor of the RNA exosome, are required for degradation of RISC 5′, but not 3′-cleavage fragments in Arabidopsis. In the absence of SKI2 activity, many miRNA targets produce siRNAs via the RNA-dependent RNA polymerase 6 (RDR6) pathway. These siRNAs are low-abundant, and map close to the cleavage site. In most cases, siRNAs were produced 5′ to the cleavage site, but several examples of 3′-spreading were also identified. These observations suggest that siRNAs do not simply derive from RDR6 action on stable 5′-cleavage fragments and hence that SKI2 has a direct role in limiting secondary siRNA production in addition to its function in mediating degradation of 5′-cleavage fragments. PMID:26464441

The ERK/CREB pathway is involved in the c-Ski expression induced by low TGF-β1 concentrations during primary fibroblast proliferation.

PubMed

Li, Ping; Liu, Ping; Peng, Yan; Zhang, Zhuo-Hang; Li, Xiao-Ming; Xiong, Ren-Ping; Chen, Xing; Zhao, Yan; Ning, Ya-Lei; Yang, Nan; Zhang, Bo; Zhou, Yuan-Guo

2018-06-27

Increasing evidence has suggested that bidirectional regulation of cell proliferation is one important effect of TGF-β1 in wound healing. Increased c-Ski expression plays a role in promoting fibroblast proliferation at low TGF-β1 concentrations, but the mechanism by which low TGF-β1 concentrations regulate c-Ski levels remains unclear. In this study, the proliferation of rat primary fibroblasts was assessed with an ELISA BrdU kit. The mRNA and protein expression and phosphorylation levels of corresponding factors were measured by RT-qPCR, immunohistochemistry or Western blotting. We first found that low TGF-β1 concentrations not only promoted c-Ski mRNA and protein expression in rat primary fibroblasts but also increased the phosphorylation levels of Extracellular Signal-Regulated Kinases (ERK) and cAMP response element binding (CREB) protein. An ERK kinase (mitogen-activated protein kinase kinase, MEK) inhibitor significantly inhibited ERK1/2 phosphorylation levels, markedly reducing c-Ski expression and CREB phosphorylation levels and abrogating the growth-promoting effect of low TGF-β1 concentrations. At the same time, Smad2/3 phosphorylation levels were not significantly changed. Taken together, these results suggest that the increased cell proliferation induced by low TGF-β1 concentrations mediates c-Ski expression potentially through the ERK/CREB pathway rather than through the classic TGF-β1/Smad pathway.

The Relationship among Leg Strength, Leg Power and Alpine Skiing Success.

ERIC Educational Resources Information Center

Gettman, Larry R.; Huckel, Jack R.

The purpose of this study was to relate leg strength and power to alpine skiing success as measured by FIS points. Isometric leg strength was represented by the knee extension test described by Clarke. Leg power was measured by the vertical jump test and the Margaria-Kalamen stair run. Results in the strength and power tests were correlated with…

[S100A7 promotes the metastasis and epithelial-mesenchymal transition on HeLa and CaSki cells].

PubMed

Tian, T; Hua, Z; Wang, L Z; Wang, X Y; Chen, H Y; Liu, Z H; Cui, Z M

2018-02-25

Objective: To elucidate the impact of over-expression of S100A7 on migration, invasion, proliferation, cell cycle, and epithelial-mesenchymal transition (EMT) in human cervical cancer HeLa and CaSki cells. Methods: (1) Immunohistochemistry of SP was used to examine the expression of S100A7 in 40 cases of squamous cervical cancer tissues and 20 cases of normal cervical tissues. (2) The vectors of pLVX-IRES-Neo-S100A7 and pLVX-IRES-Neo were used to transfect human cervical cancer HeLa and CaSki cells, and the positive clones were screened and identified. Next, transwell migration assay, cell counting kit-8 (CCK-8) assay and fluorescence activating cell sorter (FACS) were used to detect the effect of S100A7-overexpression on the migration, invasion, proliferation and cell cycle of cervical cancer cells. Furthermore, western blot was performed to observe the expression of epithelial marker (E-cadherin) and mesenchymal markers (N-cadherin, vimentin, and fibronectin) of EMT. Results: (1) S100A7 expression was significantly higher in cervical squamous cancer tissues (median 91.6) than that in normal cervical tissues (median 52.1; Z=- 2.948, P= 0.003) . (2) Stable S100A7-overexpressed cells were established using lentiviral-mediated gene delivery in HeLa and CaSki cells. S100A7 was detected by real-time quantitative reverse transcription PCR, S100A7 mRNA of S100A7-overexpressed cells were 119±3 and 177±16, increased significantly compared with control groups of median ( P< 0.01) . Compared with the control cells, the number of S100A7-overexpressed HeLa and CaSki cells that passed the transwell membrane assay were increased significanatly (572±51 vs 337±25, P< 0.01; 100±8 vs 41±4, P< 0.01) .Matrigel invasion assay showed that the number of S100A7-overexpressed HeLa and CaSki cells that passed the transwell membrane were respectively 441±15 and 110±14, elevated significantly compared with control cells (156±21 and 59±7; P< 0.05) . However, S100A7 overexpression

MiR-34a/miR-93 target c-Ski to modulate the proliferaton of rat cardiac fibroblasts and extracellular matrix deposition in vivo and in vitro.

PubMed

Zhang, Chengliang; Zhang, Yanfeng; Zhu, Hong; Hu, Jiajia; Xie, Zhongshang

2018-06-01

Cardiac fibrosis is associated with diverse heart diseases. In response to different pathological irritants, cardiac fibroblasts may be induced to proliferate and differentiate into cardiac myofibroblasts, thus contributing to cardiac fibrosis. TGF-β signaling is implicated in the development of heart failure through the induction of cardiac fibrosis. C-Ski, an inhibitory regulator of TGF-β signaling, has been reported to suppress TGF-β1-induced human cardiac fibroblasts' proliferation and ECM protein increase; however, the underlying molecular mechanism needs further investigation. In the present study, we demonstrated that c-Ski could ameliorate isoproterenol (ISO)-induced rat myocardial fibrosis model and TGF-β1-induced primary rat cardiac fibroblasts' proliferation, as well as extracellular matrix (ECM) deposition. The protein level of c-Ski was dramatically decreased in cardiac fibrosis and TGF-β1-stimulated primary rat cardiac fibroblasts. In recent decades, a family of small non-coding RNA, namely miRNAs, has been reported to regulate gene expression by interacting with diverse mRNAs and inducing either translational suppression or mRNA degradation. Herein, we selected miR-34a and miR-93 as candidate miRNAs that might target to regulate c-Ski expression. After confirming that miR-34a/miR-93 targeted c-Ski to inhibit its expression, we also revealed that miR-34a/miR-93 affected TGF-β1-induced fibroblasts' proliferation and ECM deposition through c-Ski. Taken together, we demonstrated a miR-34a/miR-93-c-Ski axis which modulates TGF-β1- and ISO-induced cardiac fibrosis in vitro and in vivo; targeting the inhibitory factors of c-Ski to rescue its expression may be a promising strategy for the treatment of cardiac fibrosis. Copyright © 2018 Elsevier Inc. All rights reserved.

36 CFR 3.12 - May I use a vessel to tow a person for water skiing or other similar activities?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false May I use a vessel to tow a person for water skiing or other similar activities? 3.12 Section 3.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.12 May I use a vessel to tow a person for water skiing o...

36 CFR 3.12 - May I use a vessel to tow a person for water skiing or other similar activities?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false May I use a vessel to tow a person for water skiing or other similar activities? 3.12 Section 3.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.12 May I use a vessel to tow a person for water skiing o...

Groundwater Flow Model for Taos, New Mexico

NASA Astrophysics Data System (ADS)

Burck, P. W.; Barroll, P. W.; Core, A. B.; Rappuhn, D.

2003-12-01

The New Mexico Office of the State Engineer - Hydrology Bureau (OSE) has developed a regional groundwater flow model for Taos, New Mexico. The MODFLOW 2000 model will serve as a tool to evaluate alternatives in settlement negotiations in an on-going water rights adjudication. If current settlement negotiations fail, it is conceivable that the model might be used in support of litigation. OSE produced the model in cooperation with technical representatives of the various parties to the adjudication. Regional hydrogeologic data including well records, aquifer test results, stream flow measurements and seepage studies have been shared relatively freely among the parties. A recent deep drilling program conducted in conjunction with the negotiation effort has added substantially to the hydrogeologic data set. Among the hydrologic processes simulated by the model are mountain front recharge; areal recharge from precipitation; evapotranspiration; discharge from springs; river and stream flow; accretions to groundwater from irrigation return flow, seepage from acequias, canals, and ditches, and deep percolation; and pumping by municipal entities and mutual domestic water users associations. The resulting model files are available for all parties to review and evaluate. Comments are assessed and many have resulted in significant improvements to the model. At this stage, however, it is unclear whether adopting this cooperative approach will increase the likelihood of model acceptance by the parties.

Cardiorespiratory endurance evaluation using heart rate analysis during ski simulator exercise and the Harvard step test in elementary school students.

PubMed

Lee, Hyo Taek; Roh, Hyo Lyun; Kim, Yoon Sang

2016-01-01

[Purpose] Efficient management using exercise programs with various benefits should be provided by educational institutions for children in their growth phase. We analyzed the heart rates of children during ski simulator exercise and the Harvard step test to evaluate the cardiopulmonary endurance by calculating their post-exercise recovery rate. [Subjects and Methods] The subjects (n = 77) were categorized into a normal weight and an overweight/obesity group by body mass index. They performed each exercise for 3 minutes. The cardiorespiratory endurance was calculated using the Physical Efficiency Index formula. [Results] The ski simulator and Harvard step test showed that there was a significant difference in the heart rates of the 2 body mass index-based groups at each minute. The normal weight and the ski-simulator group had higher Physical Efficiency Index levels. [Conclusion] This study showed that a simulator exercise can produce a cumulative load even when performed at low intensity, and can be effectively utilized as exercise equipment since it resulted in higher Physical Efficiency Index levels than the Harvard step test. If schools can increase sport durability by stimulating students' interests, the ski simulator exercise can be used in programs designed to improve and strengthen students' physical fitness.

Annual trauma load of the world's largest indoor skiing center.

PubMed

Van Laarhoven, S N; Latten, G; de Loos, E; van Hemert, W; Vles, G F

2017-04-01

There is limited data on the trauma load caused by indoor skiing centers. Therefore, all patients treated at the accident and emergency department of our level I trauma center who sustained injuries at the world's largest indoor skiing center were analyzed during a 3-year period. Business intelligence was used to identify all patients who sustained injury at SnowWorld, Landgraaf, The Netherlands, and were seen at the accident and emergency department of the Zuyderland Medical Center from January 1, 2012 till December 31, 2014. Data were collected on patient characteristics, trauma mechanism, transportation, admission, diagnostics, injury and its severity, and treatment. Of the 732 patients seen, 305 had a fracture and 80 a dislocation. Most patients were male snowboarders and most injuries were sustained during winter. More than 2000 X-rays and 100 CT scans were required. Seventy-two patients were admitted and immediate surgery was performed in 21 patients. Ten patients had Injury Severity Scores of 10 or higher. Snowboarders differed significantly from skiers on several parameters, e.g., 1 in 4 snowboarders seen had sustained a distal radius fracture compared to 1 in 100 skiers. Acquiring more insight into the characteristics of this specific patient population could benefit clinical care and help clinicians identify and target preventive strategies. IV.

[Artur Wołyński--A forgotten Polish historian in Italy in the second half of the 19th century].

PubMed

Piskurewicz, Jan

2011-01-01

Artur Wołyński (1844-1893) was, undoubtedly, one of the most interesting personages of Polish émigrés after January Uprising. He belonged to these circles of Polish émigrés, who were able to reconcile their patriotic aspirations with realities and interest of the countries that entertained them. As far as Wołyński is concerned, it found its expression in the efforts that were made in order to assimilate two nations--Polish and Italian people--appealing to the common history and familiar cultural traditions. An important element of integrating all the above-discussed actions was his scientific activity. The mentioned activity included, first of all, his studies on Nicolaus Copernicus and Galileo Galilei. In the article were analyzed more comprehensive scientific descriptions dedicated to Copernicus and Galileo prepared by Wołyński, and their significance and opinions on them of the learned, whose works treated on Copernicus and Galileo as well. Secondly, in the field of scientific activity of Wołyńiski, one can also observe his researches and the process of elaborating sources for Polish and Italian his tory, particularly concerning the 17th century. However, most of his attention Wołyński paid to collecting and working out the materials concerning January Uprising. Speaking a modern language, one can say that Wołyński in a way polled the insurgents of January Uprising sending to them an appropriate list of questions, additionally allowing for their biographies. In the paper was also included a detailed description of this broad initiative together with its results. Up till now, not much attention has been paid to this significant scientific activity and its contexts. So, the present article is to remind of meritorious personage of Wołyński, and particularly of his output within the realm of history of science, history of Polish and Italian relationships, and of the role he played in bequeathing memory of January Uprising.

Birds of the St. Croix River valley: Minnesota and Wisconsin

USGS Publications Warehouse

Faanes, Craig A.

1981-01-01

continuing expansion of the nearby Minneapolis-St. Paul metropolitan region has degraded or destroyed many woodlots, upland fields, and wetlands. In numerous instances, degradation of natural habitats has influenced the abundance and distribution of bird species. Because of these changes, both the Federal government and State Departments of Natural Resources have listed several species in various categories based on their current status. In the St. Croix River Valley, seven species are endangered, eight are threatened, and 29 are watch or priority status in either or both states. Data presented in this report are of value to land managers, land use specialists, and ornithologists, in assessing current and projected habitat alterations on the avifauna of this valley. The St. Croix River bisects a large region of western Wisconsin and east central Minnesota that exhibits a wide range of habitat types. This region supports not only birds, but many mammals, fishes, reptiles and amphibians, and several thousand species of vascular and nonvascular plants. The river itself is relatively clean through most of its course, and its natural flow is interrupted by only two small dams. Because the river lies within a 1-day drive of nearly 10 million people (Waters 1977), use of the area for recreational purposes is extremely heavy. Recreational pursuits include sunbathing, boating, and wild river kayaking in the summer, and ice fishing and cross-country skiing in the winter. The large number of unique and highly fragile habitats that exist there may never be compatible with the uses and abuses of the land that go with expanding human populations. Through the efforts of a number of citizens concerned with the quality of their environment and the foresightedness of several local, State, and Federal legislators, a portion of the upper St. Croix River Valley (hereafter termed 'the Valley') was established as a National Wild and Scenic River. Through establishment of t

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

PubMed Central

ORBAN, TAMAS I.; IZAURRALDE, ELISA

2005-01-01

RNA interference (RNAi) is a conserved RNA silencing pathway that leads to sequence-specific mRNA decay in response to the presence of double-stranded RNA (dsRNA). Long dsRNA molecules are first processed by Dicer into 21–22-nucleotide small interfering RNAs (siRNAs). The siRNAs are incorporated into a multimeric RNA-induced silencing complex (RISC) that cleaves mRNAs at a site determined by complementarity with the siRNAs. Following this initial endonucleolytic cleavage, the mRNA is degraded by a mechanism that is not completely understood. We investigated the decay pathway of mRNAs targeted by RISC in Drosophila cells. We show that 5′ mRNA fragments generated by RISC cleavage are rapidly degraded from their 3′ ends by the exosome, whereas the 3′ fragments are degraded from their 5′ ends by XRN1. Exosome-mediated decay of the 5′ fragments requires the Drosophila homologs of yeast Ski2p, Ski3p, and Ski8p, suggesting that their role as regulators of exosome activity is conserved. Our findings indicate that mRNAs targeted by siRNAs are degraded from the ends generated by RISC cleavage, without undergoing decapping or deadenylation. PMID:15703439

Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling

PubMed Central

Yin, Yizhi; Donlevy, Sean; Smolikove, Sarit

2016-01-01

Meiosis is a tightly regulated process requiring coordination of diverse events. A conserved ERK/MAPK-signaling cascade plays an essential role in the regulation of meiotic progression. The Thousand And One kinase (TAO) kinase is a MAPK kinase kinase, the meiotic role of which is unknown. We have analyzed the meiotic functions of KIN-18, the homolog of mammalian TAO kinases, in Caenorhabditis elegans. We found that KIN-18 is essential for normal meiotic progression; mutants exhibit accelerated meiotic recombination as detected both by analysis of recombination intermediates and by crossover outcome. In addition, ectopic germ-cell differentiation and enhanced levels of apoptosis were observed in kin-18 mutants. These defects correlate with ectopic activation of MPK-1 that includes premature, missing, and reoccurring MPK-1 activation. Late progression defects in kin-18 mutants are suppressed by inhibiting an upstream activator of MPK-1 signaling, KSR-2. However, the acceleration of recombination events observed in kin-18 mutants is largely MPK-1-independent. Our data suggest that KIN-18 coordinates meiotic progression by modulating the timing of MPK-1 activation and the progression of recombination events. The regulation of the timing of MPK-1 activation ensures the proper timing of apoptosis and is required for the formation of functional oocytes. Meiosis is a conserved process; thus, revealing that KIN-18 is a novel regulator of meiotic progression in C. elegans would help to elucidate TAO kinase’s role in germline development in higher eukaryotes. PMID:26510792

Valley-dependent band structure and valley polarization in periodically modulated graphene

NASA Astrophysics Data System (ADS)

Lu, Wei-Tao

2016-08-01

The valley-dependent energy band and transport property of graphene under a periodic magnetic-strained field are studied, where the time-reversal symmetry is broken and the valley degeneracy is lifted. The considered superlattice is composed of two different barriers, providing more degrees of freedom for engineering the electronic structure. The electrons near the K and K' valleys are dominated by different effective superlattices. It is found that the energy bands for both valleys are symmetric with respect to ky=-(AM+ξ AS) /4 under the symmetric superlattices. More finite-energy Dirac points, more prominent collimation behavior, and new crossing points are found for K' valley. The degenerate miniband near the K valley splits into two subminibands and produces a new band gap under the asymmetric superlattices. The velocity for the K' valley is greatly renormalized compared with the K valley, and so we can achieve a finite velocity for the K valley while the velocity for the K' valley is zero. Especially, the miniband and band gap could be manipulated independently, leading to an increase of the conductance. The characteristics of the band structure are reflected in the transmission spectra. The Dirac points and the crossing points appear as pronounced peaks in transmission. A remarkable valley polarization is obtained which is robust to the disorder and can be controlled by the strain, the period, and the voltage.

INJURY PATTERNS IN ADOLESCENT ELITE ENDURANCE ATHLETES PARTICIPATING IN RUNNING, ORIENTEERING, AND CROSS-COUNTRY SKIING.

PubMed

von Rosen, Philip; Floström, Frida; Frohm, Anna; Heijne, Annette

2017-10-01

Prospective injury registration studies, monitoring adolescent elite athletes, are sparse in running, orienteering and cross-country skiing, yet essential for developing prevention programs. The aims of this study were to describe the injury prevalence/incidence, severity grade, injury location, risk factors and the prevalence of illness in running (RU), orienteering (OR) and cross-country skiing athletes (CR). Prospective cohort study. One hundred fifty adolescent elite athletes (age range 16-19), participating in orienteering (25 females, 20 males), running (13 females, 18 males), cross-country skiing (38 females, 36 males), from 12 National Sports High Schools in Sweden, were prospectively followed over one calendar year using a reliable and validated web-based questionnaire. The main finding was that the average weekly injury prevalence was higher during the pre-season compared to the competitive season in all three sports. RU reported the significantly (p<0.05) highest average weekly injury prevalence (32.4%) and substantial injury prevalence (17.0%), compared to OR (26.0, 8.2%) and CR (21.1%, 8.9%). Most injuries occurred in the lower extremity (RU 94.4%; OR 91.9%; CR 49.9%) and foot and knee injuries had the highest severity grade in all three sports. History of serious injury (p=0.002, OR 4.0, 95% CI 1.6-9.7) and current injury at study start (p=0.004, OR 4.0, 95% CI 1.5-11.2) were identified as the strongest risk factors for substantial injury. Younger athletes aged 16 (p=0.019, OR 2.6, 95% CI 1.2-5.8) and 17 (p=0.045, OR 2.4, 95% CI 1.0-5.9), had a significantly higher injury risk for substantial injury compared to older athletes aged 18-19. Practitioners should be aware of the increased injury risk during pre-season and in younger athletes. By focus on prevention of foot and knee injuries, the injuries with the highest severity grade will be targeted in adolescent elite athletes participating in running, orienteering and cross-country skiing. 2b.

Golden eagle indifference to heli-skiing and military helicopters in northern Utah

Treesearch

Teryl G. Grubb; David K. Delaney; William W. Bowerman; Michael R. Wierda

2010-01-01

In 2006-2007, during Wasatch Powderbird Guides (WPG) permit renewal for heli-skiing in the Tri-Canyon Area (TCA) of the Wasatch Mountains, Utah, USA, we recorded 303 helicopter passes between 0 m and 3,000 m (horizontal distance) near >30 individual golden eagles (Aquila chrysaetos) in 22 nesting territories, through passive observation and active experimentation...

Underwater noise of small personal watercraft (jet skis).

PubMed

Erbe, Christine

2013-04-01

Personal watercraft (water scooters, jet skis) were recorded under water in Bramble Bay, Queensland, Australia. Underwater noise emissions consisted of broadband energy between 100 Hz and 10 kHz due to the vibrating bubble cloud generated by the jet stream, overlain with frequency-modulated tonals corresponding to impeller blade rates and harmonics. Broadband monopole source levels were 149, 137, and 122 dB re 1 μPa @ 1 m (5th, 50th, and 95th percentiles). Even though these are lower than those of small propeller-driven boats, it is not necessarily the broadband source level that correlates with the bioacoustic impact on marine fauna.

The role of incline, performance level, and gender on the gross mechanical efficiency of roller ski skating

PubMed Central

Sandbakk, Øyvind; Hegge, Ann Magdalen; Ettema, Gertjan

2013-01-01

The ability to efficiently utilize metabolic energy to produce work is a key factor for endurance performance. The present study investigated the effects of incline, performance level, and gender on the gross mechanical efficiency during roller ski skating. Thirty-one male and nineteen female elite cross-country skiers performed a 5-min submaximal session at approximately 75% of VO2peak on a 5% inclined treadmill using the G3 skating technique. Thereafter, a 5-min session on a 12% incline using the G2 skating technique was performed at a similar work rate. Gross efficiency was calculated as the external work rate against rolling friction and gravity divided by the metabolic rate using gas exchange. Performance level was determined by the amount of skating FIS points [the Federation of International Skiing (FIS) approved scoring system for ski racing] where fewer points indicate a higher performance level. Strong significant correlations between work rate and metabolic rate within both inclines and gender were revealed (r = −0.89 to 0.98 and P < 0.05 in all cases). Gross efficiency was higher at the steeper incline, both for men (17.1 ± 0.4 vs. 15.8 ± 0.5%, P < 0.05) and women (16.9 ± 0.5 vs. 15.7 ± 0.4%, P < 0.05), but without any gender differences being apparent. Significant correlations between gross efficiency and performance level were found for both inclines and genders (r = −0.65 to 0.81 and P < 0.05 in all cases). The current study demonstrated that cross-country skiers of both genders used less metabolic energy to perform the same amount of work at steeper inclines, and that the better ranked elite male and female skiers skied more efficiently. PMID:24155722

Professional ski waxers' exposure to PFAS and aerosol concentrations in gas phase and different particle size fractions.

PubMed

Nilsson, Helena; Kärrman, Anna; Rotander, Anna; van Bavel, Bert; Lindström, Gunilla; Westberg, Håkan

2013-04-01

Previous reports show that professional ski waxers have elevated blood levels of perfluorinated substances (PFAS) such as perfluorooctanoate (PFOA) and are exposed to very high concentrations of PFAS in air during ski waxing. Aerosol exposure increases the risk of cardiovascular disease, and PFOA is a potential hormonal disruptor and carcinogen, and can affect the fatty acid metabolism. Animal studies have shown that 8:2 FTOH can undergo biotransformation to PFOA. For the first time, this study presents an occupational scenario of professional ski waxers who are exposed to extremely high dust levels as well as per- and polyfluorinated compounds. Personal and fixed measurements of total aerosol, inhalable and respirable fractions were performed during World Cup events 2007-2010. The occupational exposure limit (OEL) is exceeded in 37% of the personal measurements with concentrations up to 15 mg m(-3) in air. There are differences between personal and area total aerosol concentrations with levels from personal measurements twice as high as those from the area measurements. The personal levels for FTOH ranged up to 996 μg m(-3) (mean = 114 μg m(-3)) and for PFOA up to 4.89 μg m(-3) (mean = 0.53 μg m(-3)) in ENV+ sorbent samples as compared to the general exposure levels from air reaching only low ng m(-3) (<30 ng m(-3)) levels. FTOHs were not detected in aerosols but PFOA showed an average level of 12 μg m(-3) (range = 1.2-47 μg m(-3)). The ski waxers' exposure to paraffin fumes and PFAS is not in compliance with the occupational exposure standards and by far exceed the general populations' exposure. Preventive measures must be taken to minimize the exposure in this occupational group.

The role of incline, performance level, and gender on the gross mechanical efficiency of roller ski skating.

PubMed

Sandbakk, Oyvind; Hegge, Ann Magdalen; Ettema, Gertjan

2013-01-01

The ability to efficiently utilize metabolic energy to produce work is a key factor for endurance performance. The present study investigated the effects of incline, performance level, and gender on the gross mechanical efficiency during roller ski skating. Thirty-one male and nineteen female elite cross-country skiers performed a 5-min submaximal session at approximately 75% of VO2peak on a 5% inclined treadmill using the G3 skating technique. Thereafter, a 5-min session on a 12% incline using the G2 skating technique was performed at a similar work rate. Gross efficiency was calculated as the external work rate against rolling friction and gravity divided by the metabolic rate using gas exchange. Performance level was determined by the amount of skating FIS points [the Federation of International Skiing (FIS) approved scoring system for ski racing] where fewer points indicate a higher performance level. Strong significant correlations between work rate and metabolic rate within both inclines and gender were revealed (r = -0.89 to 0.98 and P < 0.05 in all cases). Gross efficiency was higher at the steeper incline, both for men (17.1 ± 0.4 vs. 15.8 ± 0.5%, P < 0.05) and women (16.9 ± 0.5 vs. 15.7 ± 0.4%, P < 0.05), but without any gender differences being apparent. Significant correlations between gross efficiency and performance level were found for both inclines and genders (r = -0.65 to 0.81 and P < 0.05 in all cases). The current study demonstrated that cross-country skiers of both genders used less metabolic energy to perform the same amount of work at steeper inclines, and that the better ranked elite male and female skiers skied more efficiently.

[The role of Wacława Moszyński in the development of the Polish School of Machine and Mechanism Theory].

PubMed

Kisiel, Janusz; Pylak, Konrad; Schabowska, Krystyna

2005-01-01

The end of the 19th and the first half of the 20th centuries saw the emergence and intensive development of many disciplines in the technical sciences, and the laying of a groundwork for those disciplines in their current form. In Poland, a country deprived of independent statehood until 1918, this was additionally a period when native research centres and scientific schools came into being, and when Polish-language specialist literatures emerged as well. Many of the eminent personages whose activities contributed to those trends have already been described in biographical notes and articles. There are still, however, not enough studies dealing with the substance of their scientific and professional achievements. One of the personages in question was Wacława Moszyński, professor of the Warsaw Technical University, a pioneer of machine construction and mechanism theory, author of the first academic textbook in the field to be published in Poland. The current article discusses Moszyński's contribution to the development of mechanism and machine theory. The first part of the article gives an outline of the history of the discipline until 1945, presents the context of the after-war activities of the author, and evaluates his influence on the development of machine and mechanism theory in Poland; it also carries a short biography of Moszyński. The rest of the article is devoted to Moszyński's scientific achievements, and describes his approach to matters of structure, kinematics and dynamics, with special focus on those of his formulations and solution to problems that appear particularly innovative and original. The article also points out those proposals by Moszyński which made him a precursor of other disciplines, such as vibroacoustics, biomechanics and ergonomics. The paper also presents the role of Moszyński's work as a foundation for the development of the Warsaw research-and-teching centre in the field. The achievements and methods of the Warsaw school

Analysis and Comparison of the Temperature and Snowfall Conditions for the Winters of 2014/15 and 2015/16 at Three Ski Resorts in British Columbia, Canada

NASA Astrophysics Data System (ADS)

Pidwirny, M. J.; Pedersen, S.

2016-12-01

Most ski resorts located close to the west coast of Canada experienced extremely poor weather conditions during the winter of 2014/15. During this year, a persistent area of high pressure created "the Blob" in the North Pacific Ocean, which influenced weather patterns on the west coast of North America producing very mild temperatures inland. Further, for many ski resorts winter precipitation that normally arrives in the form of snow, instead fell as rain on many occasions. In Western Canada, ski resorts saw an 18% decrease in skier visits in 2014/15 relative to the average of the previous 8 years. NOAA forecasts for the winter of 2015/16 suggested another mild winter because of a strong El Nino event. Despite this forecast, ski resorts in Western Canada experienced a very good ski season. This research examines the climate characteristics of the winters of 2014/15 and 2015/16 in detail for three ski resorts in British Columbia, Canada: Whistler-Blackcomb, Cypress Mountain, and Big White. The climatic characteristics of these 2 years were also compared to the winter of 2012/13, the most recent banner ski year in the last decade. Data for this study came from Snow-Forecast.com, a web-based company that creates tailor-made weather forecasts for ski resorts around the world using climate model output from NOAA. From Snow-Forecast.com, we mined archived hindcast data that was available at the daily level to analyze and compare mean air temperature and snowfall patterns from November 1 to March 31. Daily temperature data was plotted in a line graph for each year. To better clarify trends, we also graphed an 11-year running mean for the temperature data. Snowfall data was plotted in a cumulative line graph. The winter of 2014/15 was on average warmer by 3.9°C for Cypress, 5.4°C for Whistler, and 4.4°C for Big White than the winter of 2012/13. The winter of 2015/16 was on average 2.5°C, 3.6°C, and 3.6°C warmer than the winter of 2012/13, respectively. Snowfall

Determination of the centre of mass kinematics in alpine skiing using differential global navigation satellite systems.

PubMed

Gilgien, Matthias; Spörri, Jörg; Chardonnens, Julien; Kröll, Josef; Limpach, Philippe; Müller, Erich

2015-01-01

In the sport of alpine skiing, knowledge about the centre of mass (CoM) kinematics (i.e. position, velocity and acceleration) is essential to better understand both performance and injury. This study proposes a global navigation satellite system (GNSS)-based method to measure CoM kinematics without restriction of capture volume and with reasonable set-up and processing requirements. It combines the GNSS antenna position, terrain data and the accelerations acting on the skier in order to approximate the CoM location, velocity and acceleration. The validity of the method was assessed against a reference system (video-based 3D kinematics) over 12 turn cycles on a giant slalom skiing course. The mean (± s) position, velocity and acceleration differences between the CoM obtained from the GNSS and the reference system were 9 ± 12 cm, 0.08 ± 0.19 m · s(-1) and 0.22 ± 1.28 m · s(-2), respectively. The velocity and acceleration differences obtained were smaller than typical differences between the measures of several skiers on the same course observed in the literature, while the position differences were slightly larger than its discriminative meaningful change. The proposed method can therefore be interpreted to be technically valid and adequate for a variety of biomechanical research questions in the field of alpine skiing with certain limitations regarding position.

Simulating the potential effects of climate change in two Colorado basins and at two Colorado ski areas

USGS Publications Warehouse

Battaglin, William; Hay, Lauren E.; Markstrom, Steve

2011-01-01

The mountainous areas of Colorado are used for tourism and recreation, and they provide water storage and supply for municipalities, industries, and agriculture. Recent studies suggest that water supply and tourist industries such as skiing are at risk from climate change. In this study, a distributed-parameter watershed model, the Precipitation-Runoff Modeling System (PRMS), is used to identify the potential effects of future climate on hydrologic conditions for two Colorado basins, the East River at Almont and the Yampa River at Steamboat Springs, and at the subbasin scale for two ski areas within those basins.Climate-change input files for PRMS were generated by modifying daily PRMS precipitation and temperature inputs with mean monthly climate-change fields of precipitation and temperature derived from five general circulation model (GCM) simulations using one current and three future carbon emission scenarios. All GCM simulations of mean daily minimum and maximum air temperature for the East and Yampa River basins indicate a relatively steady increase of up to several degrees Celsius from baseline conditions by 2094. GCM simulations of precipitation in the two basins indicate little change or trend in precipitation, but there is a large range associated with these projections. PRMS projections of basin mean daily streamflow vary by scenario but indicate a central tendency toward slight decreases, with a large range associated with these projections.Decreases in water content or changes in the spatial extent of snowpack in the East and Yampa River basins are important because of potential adverse effects on water supply and recreational activities. PRMS projections of each future scenario indicate a central tendency for decreases in basin mean snow-covered area and snowpack water equivalent, with the range in the projected decreases increasing with time. However, when examined on a monthly basis, the projected decreases are most dramatic during fall and spring

78 FR 45061 - Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... involved in the ski show. C. Discussion of the Final Rule With the aforementioned hazards in mind, the... on the human environment. This rule involves the establishment of a safety zone and, therefore it is...

INJURY PATTERNS IN ADOLESCENT ELITE ENDURANCE ATHLETES PARTICIPATING IN RUNNING, ORIENTEERING, AND CROSS-COUNTRY SKIING

PubMed Central

Floström, Frida; Frohm, Anna; Heijne, Annette

2017-01-01

Background Prospective injury registration studies, monitoring adolescent elite athletes, are sparse in running, orienteering and cross-country skiing, yet essential for developing prevention programs. Purpose The aims of this study were to describe the injury prevalence/incidence, severity grade, injury location, risk factors and the prevalence of illness in running (RU), orienteering (OR) and cross-country skiing athletes (CR). Study Design Prospective cohort study. Methods One hundred fifty adolescent elite athletes (age range 16-19), participating in orienteering (25 females, 20 males), running (13 females, 18 males), cross-country skiing (38 females, 36 males), from 12 National Sports High Schools in Sweden, were prospectively followed over one calendar year using a reliable and validated web-based questionnaire. Results The main finding was that the average weekly injury prevalence was higher during the pre-season compared to the competitive season in all three sports. RU reported the significantly (p<0.05) highest average weekly injury prevalence (32.4%) and substantial injury prevalence (17.0%), compared to OR (26.0, 8.2%) and CR (21.1%, 8.9%). Most injuries occurred in the lower extremity (RU 94.4%; OR 91.9%; CR 49.9%) and foot and knee injuries had the highest severity grade in all three sports. History of serious injury (p=0.002, OR 4.0, 95% CI 1.6-9.7) and current injury at study start (p=0.004, OR 4.0, 95% CI 1.5-11.2) were identified as the strongest risk factors for substantial injury. Younger athletes aged 16 (p=0.019, OR 2.6, 95% CI 1.2-5.8) and 17 (p=0.045, OR 2.4, 95% CI 1.0-5.9), had a significantly higher injury risk for substantial injury compared to older athletes aged 18-19. Conclusion Practitioners should be aware of the increased injury risk during pre-season and in younger athletes. By focus on prevention of foot and knee injuries, the injuries with the highest severity grade will be targeted in adolescent elite athletes participating in

77 FR 33237 - Saline Valley Warm Springs Management Plan/Environmental Impact Statement, Death Valley National...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... Valley Warm Springs Management Plan/Environmental Impact Statement, Death Valley National Park, Inyo... an Environmental Impact Statement for the Saline Valley Warm Springs Management Plan, Death Valley... analysis process for the Saline Valley Warm Springs Management Plan for Death Valley [[Page 33238...

Water demand for ski resort development in the Austrian Alps: an Overview

NASA Astrophysics Data System (ADS)

Breiling, M.; Sokratov, S.

2012-04-01

Austria has the highest national added value from winter tourism in Europe, as well as worldwide. 15.7 million arrivals were counted in Austrian accommodation establishments in the 2010/11 winter season. There were more than 62 million overnight stays and 51.2 million skier-days were consumed. 588 million transports were carried out by more than 3000 lifts (cable cars, chair lifts and T-bars). Including indirect and induced effects, this resulted in more than 10 billion euros in added value being generated. The lack of snow in many Austrian skiing areas during the 2006/2007 winter season demonstrated the extent to which meteorological conditions influence operations. Declines in the number of skiers transported and total skier days were the result. The cable-car operators also had to struggle with little snow in the 2010/2011 winter. The Austrian Cable Car Operators' Association stated that the opening of 70-80% of all skiing areas outside of the peak season could only be assured through the use of snowmaking equipment. The central criterion for winter sports enthusiasts to make a trip is the guarantee that they will find snow at their destination and Austria's cable-car operators invest more than 100 million euros in the erection and improvement of snowmaking complexes every year to satisfy this deand. In the 2010/2011 season, this provided for 17,800 jobs. Cable car operators set up snowmaking equipment to become independent from meteorological conditions and improve the capacity utilisation of their expensive investments in transport systems in the early winter. Austria has a skiing area of around 25,400 hectares - around 17,000 hectares at altitudes between 600m and 3200m are currently suitable for snowmaking. As much as 70% of the snow is produced immediately before the start of the season. This recent trend is responsible that the irrigation pattern of Austrian land use changed significantly in the last decade. Previously maize fields and low lands in summer

Comparison of tibial shaft ski fractures in children and adults.

PubMed

Hamada, Tomo; Matsumoto, Kazu; Ishimaru, Daichi; Sumi, Hiroshi; Shimizu, Katsuji

2014-09-01

To examine whether child and adult skiers have different risk factors or mechanisms of injury for tibial shaft fractures. Descriptive epidemiological study. Prospectively analyzed the epidemiologic factors, injury types, and injury mechanisms at Sumi Memorial Hospital. This study analyzed information obtained from 276 patients with tibial fractures sustained during skiing between 2004 and 2012. We focused on 174 ski-related tibial shaft fractures with respect to the following factors: age, gender, laterality of fracture, skill level, mechanism of fracture (fall vs collision), scene of injury (steepness of slope), snow condition, and weather. Fracture pattern was graded according to Arbeitsgemeinschaft für Osteosynthesefragen (AO) classification and mechanical direction [external (ER) or internal rotation (IR)]. Tibial shaft fractures were the most common in both children (89.3%) and adults (47.4%). There were no significant differences in gender, side of fracture, mechanism of fracture, snow condition, or weather between children and adults. Skill levels were significantly lower in children than in adults (P < 0.0001). Type A fractures were more dominant in children (73 cases, 72.3%) than in adults (39 cases, 53.4%). There was significantly more ER in children than in adults (P < 0.0001). Among children, female patients had significantly more IR than ER; in contrast, among adults, women were injured by ER. We found significant differences in some of these parameters, suggesting that child and adult skiers have different risk factors or mechanisms of injury for tibial shaft fractures.

27 CFR 9.57 - Green Valley of Russian River Valley.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Green Valley of Russian River Valley. 9.57 Section 9.57 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.57 Green Valley of Russian River...

27 CFR 9.57 - Green Valley of Russian River Valley.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Green Valley of Russian River Valley. 9.57 Section 9.57 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.57 Green Valley of Russian River...

27 CFR 9.57 - Green Valley of Russian River Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Green Valley of Russian River Valley. 9.57 Section 9.57 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.57 Green Valley of Russian River...

27 CFR 9.57 - Green Valley of Russian River Valley.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Green Valley of Russian River Valley. 9.57 Section 9.57 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.57 Green Valley of Russian River...

27 CFR 9.57 - Green Valley of Russian River Valley.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Green Valley of Russian River Valley. 9.57 Section 9.57 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.57 Green Valley of Russian River...

Collecting Kinematic Data on a Ski Track with Optoelectronic Stereophotogrammetry: A Methodological Study Assessing the Feasibility of Bringing the Biomechanics Lab to the Field

PubMed Central

Müller, Erich

2016-01-01

In the laboratory, optoelectronic stereophotogrammetry is one of the most commonly used motion capture systems; particularly, when position- or orientation-related analyses of human movements are intended. However, for many applied research questions, field experiments are indispensable, and it is not a priori clear whether optoelectronic stereophotogrammetric systems can be expected to perform similarly to in-lab experiments. This study aimed to assess the instrumental errors of kinematic data collected on a ski track using optoelectronic stereophotogrammetry, and to investigate the magnitudes of additional skiing-specific errors and soft tissue/suit artifacts. During a field experiment, the kinematic data of different static and dynamic tasks were captured by the use of 24 infrared-cameras. The distances between three passive markers attached to a rigid bar were stereophotogrammetrically reconstructed and, subsequently, were compared to the manufacturer-specified exact values. While at rest or skiing at low speed, the optoelectronic stereophotogrammetric system’s accuracy and precision for determining inter-marker distances were found to be comparable to those known for in-lab experiments (< 1 mm). However, when measuring a skier’s kinematics under “typical” skiing conditions (i.e., high speeds, inclined/angulated postures and moderate snow spraying), additional errors were found to occur for distances between equipment-fixed markers (total measurement errors: 2.3 ± 2.2 mm). Moreover, for distances between skin-fixed markers, such as the anterior hip markers, additional artifacts were observed (total measurement errors: 8.3 ± 7.1 mm). In summary, these values can be considered sufficient for the detection of meaningful position- or orientation-related differences in alpine skiing. However, it must be emphasized that the use of optoelectronic stereophotogrammetry on a ski track is seriously constrained by limited practical usability, small-sized capture

Standing Height as a Prevention Measure for Overuse Injuries of the Back in Alpine Ski Racing: A Kinematic and Kinetic Study of Giant Slalom

PubMed Central

Spörri, Jörg; Kröll, Josef; Fasel, Benedikt; Aminian, Kamiar; Müller, Erich

2018-01-01

Background: In alpine ski racing, typical loading patterns of the back include a combined occurrence of spinal bending, torsion, and high peak loads. These factors are known to be associated with high spinal disc loading and have been suggested to be attributable to different types of spine deterioration. However, little is known about the effect of standing height (ie, the distance between the bottom of the running surface of the ski and the ski boot sole) on the aforementioned back loading patterns. Purpose: To investigate the effect of reduced standing height on the skier’s overall trunk kinematics and the acting ground-reaction forces in giant slalom (GS) from an overuse injury prevention perspective. Study Design: Controlled laboratory study. Methods: Seven European Cup–level athletes skied a total of 224 GS turns with 2 different pairs of skis varying in standing height. Their overall trunk movement (frontal bending, lateral bending, and torsion angles) was measured based on 2 inertial measurement units located at the sacrum and sternum. Pressure insoles were used to determine the total ground-reaction force. Results: During the turn phase in which the greatest spinal disc loading is expected to occur, significantly lower total ground-reaction forces were observed for skis with a decreased standing height. Simultaneously, the skier’s overall trunk movement (ie, frontal bending, lateral bending, and torsion angles) remained unwaveringly high. Conclusion: Standing height is a reasonable measure to reduce the skier’s overall back loading in GS. Yet, when compared with the effects achievable by increased gate offsets in slalom, for instance, the preventative benefits of decreased standing height seem to be rather small. Clinical Relevance: To reduce the magnitude of overall back loading in GS and to prevent overuse injuries of the back, decreasing standing height might be an efficient approach. Nevertheless, the clinical relevance of the current findings

Collecting Kinematic Data on a Ski Track with Optoelectronic Stereophotogrammetry: A Methodological Study Assessing the Feasibility of Bringing the Biomechanics Lab to the Field.

PubMed

Spörri, Jörg; Schiefermüller, Christian; Müller, Erich

2016-01-01

In the laboratory, optoelectronic stereophotogrammetry is one of the most commonly used motion capture systems; particularly, when position- or orientation-related analyses of human movements are intended. However, for many applied research questions, field experiments are indispensable, and it is not a priori clear whether optoelectronic stereophotogrammetric systems can be expected to perform similarly to in-lab experiments. This study aimed to assess the instrumental errors of kinematic data collected on a ski track using optoelectronic stereophotogrammetry, and to investigate the magnitudes of additional skiing-specific errors and soft tissue/suit artifacts. During a field experiment, the kinematic data of different static and dynamic tasks were captured by the use of 24 infrared-cameras. The distances between three passive markers attached to a rigid bar were stereophotogrammetrically reconstructed and, subsequently, were compared to the manufacturer-specified exact values. While at rest or skiing at low speed, the optoelectronic stereophotogrammetric system's accuracy and precision for determining inter-marker distances were found to be comparable to those known for in-lab experiments (< 1 mm). However, when measuring a skier's kinematics under "typical" skiing conditions (i.e., high speeds, inclined/angulated postures and moderate snow spraying), additional errors were found to occur for distances between equipment-fixed markers (total measurement errors: 2.3 ± 2.2 mm). Moreover, for distances between skin-fixed markers, such as the anterior hip markers, additional artifacts were observed (total measurement errors: 8.3 ± 7.1 mm). In summary, these values can be considered sufficient for the detection of meaningful position- or orientation-related differences in alpine skiing. However, it must be emphasized that the use of optoelectronic stereophotogrammetry on a ski track is seriously constrained by limited practical usability, small-sized capture volumes

Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration.

PubMed

Macias-Silva, Marina; Li, Wei; Leu, Julia I; Crissey, Mary Ann S; Taub, Rebecca

2002-08-09

Transforming growth factor-beta (TGF-beta) functions as an antiproliferative factor for hepatocytes. However, for unexplained reasons, hepatocytes become resistant to TGF-beta signals and can proliferate despite the presence of TGF-beta during liver regeneration. TGF-beta is up-regulated during liver regeneration, although it is not known whether it is active or latent. TGF-beta activity may be examined by assessing Smad activation, a downstream signaling pathway. Smad pathway activation during liver regeneration induced by partial hepatectomy or CC4 injury was examined by assessing the levels of phospho-Smad2 and Smad2-Smad4 complexes. We found that Smad proteins were slightly activated in quiescent liver, but that their activation was further enhanced in regenerating liver. Interestingly, TGF-beta/Smad pathway inhibitors (SnoN and Ski) were up-regulated during regeneration, and notably, SnoN was induced mainly in hepatocytes. SnoN and Ski are transcriptional repressors that may render some cells resistant to TGF-beta via binding Smad proteins. Complexes between SnoN, Ski, and the activated Smad proteins were detected from 2 to 120 h during the major proliferative phase in regenerating liver. Inhibitory complexes decreased after liver mass restitution (5-15 days), suggesting that persistently activated Smad proteins might participate in returning the liver to a quiescent state. Our data show that active TGF-beta/Smad signals are present during regeneration and suggest that SnoN/Ski induction might explain hepatocyte resistance to TGF-beta during the proliferative phase.

Skill Acquisition in Ski Instruction and the Skill Model's Application to Treating Anorexia Nervosa

ERIC Educational Resources Information Center

Duesund, Liv; Jespersen, Ejgil

2004-01-01

The Dreyfus skill model has a wide range of applications to various domains, including sport, nursing, engineering, flying, and so forth. In this article, the authors discuss the skill model in connection with two different research projects concerning ski instruction and treating anorexia nervosa. The latter project has been published but not in…

Morphology of large valleys on Hawaii - Evidence for groundwater sapping and comparisons with Martian valleys

NASA Technical Reports Server (NTRS)

Kochel, R. Craig; Piper, Jonathan F.

1986-01-01

Morphometric data on the runoff and sapping valleys on the slopes of Hawaii and Molokai in Hawaii are analyzed. The analysis reveals a clear distinction between the runoff valleys and sapping valleys. The Hawaiian sapping valleys are characterized by: (1) steep valley walls and flat floors, (2) amphitheater heads, (3) low drainage density, (4) paucity of downstream tributaries, (5) low frequency of up-dip tributaries, and (6) structural and stratigraphic control on valley patterns. The characteristics of the Hawaiian sapping valleys are compared to Martian valleys and experimental systems, and good correlation between the data is detected. Flume experiments were also conducted to study the evolution of sapping valleys in response to variable structure and stratigraphy.

Jumping for recognition: Women's ski jumping viewed as a struggle for rights.

PubMed

Andersen, W; Loland, S

2017-03-01

With the campaign for women's participation in international and Olympic ski jumping as a practical case, sport's potential for recognition of individual rights is explored. In line with Honneth's influential ethical theory, recognition of rights refers to a mutual recognition between persons of each other as rational and responsible agents with an equal right to take part in the public formation and development of their community or practice. The argument is that women ski jumpers were entitled to compete as they had actual and/or potential capabilities and skills to contribute in the public formation and development of their sport. Their exclusion was a violation of individual rights. At a more general level, sport is discussed as a sphere for recognition of rights. It is argued that the basic principles of equal opportunity to take part and to perform make sport a particularly clear and potent sphere for such recognition, and also for the identification of rights violations. In sport, rights, or the violation of rights, are demonstrated in concrete and embodied ways. It is concluded that struggles for recognition and individual rights are a continuous process in sport as in most other human institutions and practices. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Magnetotelluric data, Taos Plateau Volcanic Field, New Mexico

USGS Publications Warehouse

Ailes, Chad E.; Rodriguez, Brian D.

2010-01-01

The population of the San Luis Basin region of northern New Mexico is growing. Water shortfalls could have serious consequences. Future growth and land management in the region depend on accurate assessment and protection of the region's groundwater resources. An important issue in managing the groundwater resources is a better understanding of the hydrogeology of the Santa Fe Group and the nature of the sedimentary deposits that fill the Rio Grande rift, which contain the principal groundwater aquifers. The shallow unconfined aquifer and the deeper confined Santa Fe Group aquifer in the San Luis Basin are the main sources of municipal water for the region. The U.S. Geological Survey (USGS) is conducting a series of multidisciplinary studies of the San Luis Basin. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, an electromagnetic survey called magnetotellurics (MT), and hydrologic and lithologic data are being used to better understand the aquifers. This report describes a regional east-west MT sounding profile acquired in late July 2009 across the Taos Plateau Volcanic Field where drillhole data are sparse. Resistivity modeling of the MT data can be used to help map changes in electrical resistivity with depths that are related to differences in rock types. These various rock types help control the properties of aquifers. The purpose of this report is to release the MT sounding data collected along the east-west profile. No interpretation of the data is included.

Accelerations induced by body motions during snow skiing

NASA Astrophysics Data System (ADS)

Mote, C. D.; Louie, J. K.

1983-05-01

Work done by the snow skier during pumping and rocking the center of mass can result in significant accelerations. Pumping and rocking strategies maximizing the velocity of a particle over undulating snow surfaces have been investigated in this paper. The prescribed motions included translation of the particle mass radially from a point contact with the snow surface and rocking of the point contact forward and backward in the vertical plane. The mechanics of the induced velocity variations and the expected magnitude of the velocity variation were of primary interest. The equations of motion were integrated numerically to determine skier-ski model velocity. Positive and negative variations in velocity from 10% to 100% were predicted with pumping strategies over distances of 10-15 m.

Mutations in the TGF-β Repressor SKI Cause Shprintzen-Goldberg Syndrome with Aortic Aneurysm

PubMed Central

Doyle, Alexander J.; Doyle, Jefferson J.; Bessling, Seneca L.; Maragh, Samantha; Lindsay, Mark E.; Schepers, Dorien; Gillis, Elisabeth; Mortier, Geert; Homfray, Tessa; Sauls, Kimberly; Norris, Russell A.; Huso, Nicholas D.; Leahy, Dan; Mohr, David W.; Caulfield, Mark J.; Scott, Alan F.; Destrée, Anne; Hennekam, Raoul C.; Arn, Pamela H.; Curry, Cynthia J.; Van Laer, Lut; McCallion, Andrew S.; Loeys, Bart L.; Dietz, Harry C.

2012-01-01

Increased transforming growth factor beta (TGF-β) signaling has been implicated in the pathogenesis of syndromic presentations of aortic aneurysm, including Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS)1-4. However, the location and character of many of the causal mutations in LDS would intuitively infer diminished TGF-β signaling5. Taken together, these data have engendered controversy regarding the specific role of TGF-β in disease pathogenesis. Shprintzen-Goldberg syndrome (SGS) has considerable phenotypic overlap with MFS and LDS, including aortic aneurysm6-8. We identified causative variation in 10 patients with SGS in the proto-oncogene SKI, a known repressor of TGF-β activity9,10. Cultured patient dermal fibroblasts showed enhanced activation of TGF-β signaling cascades and increased expression of TGF-β responsive genes. Morpholino-induced silencing of SKI paralogs in zebrafish recapitulated abnormalities seen in SGS patients. These data support the conclusion that increased TGF-β signaling is the mechanism underlying SGS and contributes to multiple syndromic presentations of aortic aneurysm. PMID:23023332

78 FR 33047 - Humboldt-Toiyabe National Forest, Carson Ranger District Mt. Rose Ski Tahoe-Atoma Area...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... the effects of a proposal from Mt. Rose Ski Tahoe (Mt. Rose) to expand its lift and terrain network... to create the Atoma lift and trail ``Pod'' to the north of the Mt. Rose Highway. The proposed Atoma... facilitate construction and [[Page 33048

Investigating potential effects of heli-skiing on golden eagles in the Wasatch Mountains, Utah

Treesearch

Teryl G. Grubb; David K. Delaney; William W. Bowerman

2007-01-01

Implementing further research was beyond the scope of the U.S. Forest Service's 2004 Final Environmental Impact Statement (FEIS) and 2005 Wasatch Powderbird Guides (WPG) Special Use Permit Renewal process for heli-skiing in the Tri-Canyon Area in the Wasatch Mountains, just east of Salt Lake City, Utah. However, in their Record of Decision the Wasaatch-Cache (WCNF...

Motivational Factors Affecting Athletes in Selecting the Sport Branches of Athletics, Ski and Tennis

ERIC Educational Resources Information Center

Akyüz, Murat; Agar, Muharrem; Akyüz, Öznur; Dogru, Yeliz

2016-01-01

The aim of this study is to research the motivational factors affecting athletes to select the branches of athletics, ski and tennis. Within the scope of the research, the survey developed by H. Sunay in 1996 was implemented and solution for the problem of the research was searched through the findings that were obtained from the survey. SPSS…

Automatic Classification of Sub-Techniques in Classical Cross-Country Skiing Using a Machine Learning Algorithm on Micro-Sensor Data

PubMed Central

Seeberg, Trine M.; Tjønnås, Johannes; Haugnes, Pål; Sandbakk, Øyvind

2017-01-01

The automatic classification of sub-techniques in classical cross-country skiing provides unique possibilities for analyzing the biomechanical aspects of outdoor skiing. This is currently possible due to the miniaturization and flexibility of wearable inertial measurement units (IMUs) that allow researchers to bring the laboratory to the field. In this study, we aimed to optimize the accuracy of the automatic classification of classical cross-country skiing sub-techniques by using two IMUs attached to the skier’s arm and chest together with a machine learning algorithm. The novelty of our approach is the reliable detection of individual cycles using a gyroscope on the skier’s arm, while a neural network machine learning algorithm robustly classifies each cycle to a sub-technique using sensor data from an accelerometer on the chest. In this study, 24 datasets from 10 different participants were separated into the categories training-, validation- and test-data. Overall, we achieved a classification accuracy of 93.9% on the test-data. Furthermore, we illustrate how an accurate classification of sub-techniques can be combined with data from standard sports equipment including position, altitude, speed and heart rate measuring systems. Combining this information has the potential to provide novel insight into physiological and biomechanical aspects valuable to coaches, athletes and researchers. PMID:29283421

Development status of the mid-infrared two-field camera and spectrograph MIMIZUKU for the TAO 6.5-m Telescope

NASA Astrophysics Data System (ADS)

Kamizuka, Takafumi; Miyata, Takashi; Sako, Shigeyuki; Ohsawa, Ryou; Okada, Kazushi; Uchiyama, Masahito S.; Mori, Kiyoshi; Yamaguchi, Jumpei; Asano, Kentaro; Uchiyama, Mizuho; Sakon, Itsuki; Onaka, Takashi; Kataza, Hirokazu; Hasegawa, Sunao; Usui, Fumihiko; Takato, Naruhisa; Aoki, Tsutomu; Doi, Mamoru; Kato, Natsuko M.; Kitagawa, Yutaro; Kobayakawa, Yutaka; Kohno, Kotaro; Konishi, Masahiro; Minezaki, Takeo; Morokuma, Tomoki; Motohara, Kentaro; Ohashi, Hirofumi; Soyano, Takao; Takahashi, Hidenori; Tamura, Yoichi; Tanabé, Toshihiko; Tanaka, Masuo; Tarusawa, Ken'ichi; Terao, Yasunori; Yoshii, Yuzuru

2016-08-01

MIMIZUKU is the first-generation mid-infrared instrument for the university of Tokyo Atacama Observatory (TAO) 6.5-m telescope. MIMIZUKU provides imaging and spectroscopic monitoring capabilities in a wide wavelength range from 2 to 38 μm, including unique bands like 2.7-μm and 30-μm band. Recently, we decided to add spectroscopic functions, KL-band mode (λ= 2.1-4.0 μm R =λ/Δλ 210) and 2.7-μm band mode ( λ= 2.4-2.95 μm R 620), and continuous spectroscopic coverage from 2.1 to 26 μm is realized by this update. Their optical designing is completed, and fabrications of optical elements are ongoing. As recent progress, we also report the completion of the cryogenic system and optics. The cryogenic system has been updated by changing materials and structures of thermal links, and the temperatures of the optical bench and detector mounting stages finally achieved required temperatures. Their stability against instrument attitude is also confirmed through an inclination test. As for the optics, its gold-plated mirrors have been recovered from galvanic corrosion by refabrication and reconstruction. Enough image quality and stability are confirmed by room-temperature tests. MIMIZUKU is intended to be completed in this autumn, and commissioning at the Subaru telescope and scientific operations on the TAO telescope are planned in 2017 and around 2019, respectively. In this paper, these development activities and future prospects of MIMIZUKU are reported.

Valley Fever (Coccidioidomycosis) Statistics

MedlinePlus

... Valley fever may be under-recognized. 2 , 3 Public health surveillance for Valley fever Valley fever is reportable ... MMWR) . Check with your local, state, or territorial public health department for more information about disease reporting requirements ...

Projections for Changes in Natural and Technical Snow Reliability of a Major Turkish Ski Resort by Using RegCM4.3.5

NASA Astrophysics Data System (ADS)

Ozturk, Tugba; Cenk Demiroglu, O.; Tufan Turp, M.; Türkeş, Murat; Kurnaz, M. Levent

2014-05-01

Climate change has been and increasingly will be a major threat to the ski tourism industry whose survival is highly dependent on existence of snow cover of sufficient depth and duration. The common knowledge requires that in order for a ski resort to be viable, it has to perform operations for at least 100 days in seven out of ten winters. For this matter, it is now even more usual for the ski resorts to adapt to this issue by technical snowmaking. In this study, projected future changes for the period of 2010-2040, 2040-2070, and 2070-2100 in air temperature, relative humidity, and snow depth climatology and variability with respect to the control period of 1970-2000 were assessed for the domain of a major ski resort in Turkey. Regional Climate Model (RegCM4.3.5) of ICTP (International Centre for Theoretical Physics) was used for projections of future and present climate conditions. HadGEM2 global climate model of the Met Office Hadley Centre, MPI-ESM-MR of the Max Planck Institute for Meteorology, GFDL-ESM2M of the National Oceanic and Atmospheric Administration Geophysical Fluid Dynamics Laboratory were downscaled to 10 km for the resort and its surrounding region. Both the projections and the downscaling were realized according to the RCP4.5 and the RCP8.5 emission scenarios of the IPCC. The outputs on snow depth were used for a count of the changes on snow cover duration sufficient for skiing actitivies, signaling natural snow-reliability, whereas the outputs on air temperature and relative humidity were utilized for determination of wet-bulb temperatures. The latter measure was used to interpret the changes in the snowmaking capacity, in other words; technical snow-reliability, of the resort. This work was supported by the BU Reasearch Fund under the project number 7362. One of the authors (MLK) was partially supported by Mercator-IPC Fellowship Program.

The susceptibility of TaO x-based memristors to high dose rate ionizing radiation and total ionizing dose

DOE PAGES

McLain, Michael Lee; Sheridan, Timothy J.; Hjalmarson, Harold Paul; ...

2014-11-11

This paper investigates the effects of high dose rate ionizing radiation and total ionizing dose (TID) on tantalum oxide (TaO x) memristors. Transient data were obtained during the pulsed exposures for dose rates ranging from approximately 5.0 ×10 7 rad(Si)/s to 4.7 ×10 8 rad(Si)/s and for pulse widths ranging from 50 ns to 50 μs. The cumulative dose in these tests did not appear to impact the observed dose rate response. Static dose rate upset tests were also performed at a dose rate of ~3.0 ×10 8 rad(Si)/s. This is the first dose rate study on any type ofmore » memristive memory technology. In addition to assessing the tolerance of TaO x memristors to high dose rate ionizing radiation, we also evaluated their susceptibility to TID. The data indicate that it is possible for the devices to switch from a high resistance off-state to a low resistance on-state in both dose rate and TID environments. The observed radiation-induced switching is dependent on the irradiation conditions and bias configuration. Furthermore, the dose rate or ionizing dose level at which a device switches resistance states varies from device to device; the enhanced susceptibility observed in some devices is still under investigation. As a result, numerical simulations are used to qualitatively capture the observed transient radiation response and provide insight into the physics of the induced current/voltages.« less

Injuries and illnesses in a cohort of elite youth alpine ski racers and the influence of biological maturity and relative age: a two-season prospective study

PubMed Central

Müller, Lisa; Hildebrandt, Carolin; Müller, Erich; Oberhoffer, Renate; Raschner, Christian

2017-01-01

Background Studies on injuries and illnesses involving youth ski racers younger than 15 years are lacking in the literature. The aim of this study was prospectively to assess the incidence, prevalence, and severity of traumatic and overuse injuries, as well as illnesses of elite youth ski racers with regard to sex, biological maturity status, and relative age. Subjects and methods A prospective, longitudinal cohort design was used to monitor the anthropometrics, training characteristics, traumatic and overuse injuries, and illnesses of 82 elite youth ski racers (51 males, 31 females, age 9–14 years) over 2 consecutive years. The exact training exposure (skiing and athletic) was recorded. Relative age and estimated biological maturity status were assessed. Results Relatively low injury incidence or prevalence (traumatic, 0.86/1,000 hours of training; overuse, 0.28/1,000 hours) and comparably high illness prevalence (2.4/athlete) were reported. The knee was the most commonly affected body part (traumatic injuries 36.5%, overuse injuries 82%). A high number of bone fractures were revealed (46%), while no stress fractures occurred; 66% of the illnesses were respiratory tract infections. No differences were found between males and females, the differing maturity groups, or relative age quartiles. Early-maturing athletes had comparably low traumatic and overuse-injury rates. Relatively younger athletes had low traumatic injury rates. Conclusion The injury-prevention measures implemented in the training process of youth ski racers seem to contribute to a low incidence of injury. Biological maturity status should be considered in the training process to prevent injuries in late-maturing athletes. PMID:28546774

Line focus concentrating collector for Copper Mountain Ski Resort, Colorado (Engineering Materials)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1983-06-02

The present invention is a device which develops an accurate line focus concentrating collector by flexural bending of thin reflective materials. This method avoids the need for expensive tooling and support frame fabrication. The technical work conducted during this quarter included completion of designs for the prototype system for the Copper Mountain Ski Resort in Colorado. Evaluation of alternate tracking and drive systems and final design of the support system. These drawings accompany DOE/CS/15072--T4.

Valley polarization in bismuth

NASA Astrophysics Data System (ADS)

Fauque, Benoit

2013-03-01

The electronic structure of certain crystal lattices can contain multiple degenerate valleys for their charge carriers to occupy. The principal challenge in the development of valleytronics is to lift the valley degeneracy of charge carriers in a controlled way. In bulk semi-metallic bismuth, the Fermi surface includes three cigar-shaped electron valleys lying almost perpendicular to the high symmetry axis known as the trigonal axis. The in-plane mass anisotropy of each valley exceeds 200 as a consequence of Dirac dispersion, which drastically reduces the effective mass along two out of the three orientations. According to our recent study of angle-dependent magnetoresistance in bismuth, a flow of Dirac electrons along the trigonal axis is extremely sensitive to the orientation of in-plane magnetic field. Thus, a rotatable magnetic field can be used as a valley valve to tune the contribution of each valley to the total conductivity. As a consequence of a unique combination of high mobility and extreme mass anisotropy in bismuth, the effect is visible even at room temperature in a magnetic field of 1 T. Thus, a modest magnetic field can be used as a valley valve in bismuth. The results of our recent investigation of angle-dependent magnetoresistance in other semi-metals and doped semiconductors suggest that a rotating magnetic field can behave as a valley valve in a multi-valley system with sizeable mass anisotropy.

75 FR 11511 - Rogue River-Siskiyou National Forest; Mt. Ashland Ski Area Expansion, Jackson County, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

.... Ashland Ski Area (MASA) expansion, selecting Alternative 2 with some modifications adopted from... declaratory and injunctive relief on the grounds that the MASA expansion project violated both the NEPA and... instructed it to promptly enjoin the MASA expansion project contemplated in the 2004 ROD until the Forest...

SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet.

PubMed

Potì, Francesco; Ceglarek, Uta; Burkhardt, Ralph; Simoni, Manuela; Nofer, Jerzy-Roch

2015-05-01

Sphingosine 1-phosphate (S1P) is a lysosphingolipid associated with high-density lipoproteins (HDL) that contributes to their anti-atherogenic potential. We investigated whether a reduction in S1P plasma levels affects atherosclerosis in low-density lipoprotein receptor deficient (LDL-R-/-) mice. LDL-R-/- mice on Western diet containing low (0.25% w/w) or high (1.25% w/w) cholesterol were treated for 16 weeks with SKI-II, a sphingosine kinase 1 inhibitor that significantly reduced plasma S1P levels. SKI-II treatment increased atherosclerotic lesions in the thoracic aorta in mice on high but not low cholesterol diet. This compound did not affect body weight, blood cell counts and plasma total and HDL cholesterol, but decreased triglycerides. In addition, mice on high cholesterol diet receiving SKI-II showed elevated levels of tumor necrosis factor-α and endothelial adhesion molecules (sICAM-1, sVCAM-1). Prolonged lowering of plasma S1P produces pro-atherogenic effects in LDL-R-/- mice that are evident under condition of pronounced hypercholesterolemia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

What Crested Butte Mountain Resort Feels the Ski Industry Is, In General, Looking for in College Graduates.

ERIC Educational Resources Information Center

Jernigan, Rick

This paper describes general employment requirements for employment candidates in the skiing industry, as seen by Crested Butte Mountain Resort personnel. General educational requirements are primarily business skills, including: communications, computers, math, finance, accounting, economics, personnel administration, and psychology. Other…

Changes of chromium concentration in alluvial sediments of the Obra river valley

NASA Astrophysics Data System (ADS)

Młynarczyk, Z.; Sobczyński, T.; Słowik, M.

2006-06-01

In this research work, changes in concentration of the chosen chemical element in alluvial sediments have been used to estimate the relative age of floodplain deposits. The research concerning changes of chromium concentration in alluvial deposits was done in the Obra river valley near Międzyrzecz (Western Poland). Chromium was chosen because of its low ability to migrate in groundwater environment. Moreover, this chemical element was used in the process of dyeing textures in Międzyrzecz between the sixteenth and the nineteenth century. Confrontation of changes in chromium concentration and age of alluvial sediments (age estimated in years BP using radiocarbon method) have shown that the sediments with higher chromium contents are much older than the period of development of the weaving industry in Międzyrzecz. Therefore, it is not possible to use changes in chromium concentration to estimate relative age of floodplain sediments. Despite information in the literature about low migration ability of this chemical component (Macioszczyk and Dobrzyński in Hydrogeochemia: strefy aktywnej wymiany wód podziemnych. PWN, Warszawa, 2002; Ball and Izbicki in Appl Geochem 19:1123 1135, 2004) migration of chromium is so intensive that distinct changes in its concentration are observed even before the period of increased human activity.

What are the exercise-based injury prevention recommendations for recreational alpine skiing and snowboarding? A systematic review.

PubMed

Hébert-Losier, Kim; Holmberg, Hans-Christer

2013-05-01

Skiing and snowboarding are two activities that significantly contribute to the total number of sports-related injuries reported per year. Strength, endurance and cardiovascular fitness are central components in sports injury prevention. Providing exercises and training recommendations specific to recreational skiers and snowboarders is important in both injury prevention and reducing the prevalence and cost associated with alpine winter sports injuries. The aim of this paper was to systematically review the literature for injury prevention recommendations specific to recreational alpine skiers and snowboarders. The focus was to discern recommendations that targeted physical fitness, exercise and/or training in the prevention of musculoskeletal injuries in these two sports. Fourteen electronic databases were searched in October 2011 using relevant MeSH terms and key words. Articles were included if they addressed injury prevention, recreational alpine skiing or snowboarding and musculoskeletal injuries. Only original research articles published in peer-reviewed journals, and in the English-language, were reviewed. Articles on elite athletes were excluded. Two independent reviewers quality assessed articles meeting inclusion criteria using a modified version of the Downs and Black Quality Assessment Checklist. Data on study population, study design, study location and injury prevention recommendation(s) were extracted from articles using a standard form and subsequently categorized to facilitate data synthesis. A total of 30 articles met the inclusion criteria and were reviewed, having an average ± standard deviation quality score of 72% ± 17% (range: 23-100 %). Overall, 80 recommendations for the prevention of musculoskeletal injuries in recreational alpine skiers and snowboarders were identified and classified into five main groups: equipment (n = 24), education and knowledge (n = 11), awareness and behaviour (n = 15), experience (n = 10) and third

Tao-Rusyr Caldera, Onekotan Island, Kuril Islands

NASA Image and Video Library

2017-12-08

More than 9,000 years ago, a catastrophic volcanic eruption created a huge caldera on the southern end of Onekotan Island, one of the Kuril Islands, located off the southern tip of Russia’s Kamchatka Peninsula. Today, the ancient Tao-Rusyr Caldera is filled by the deep blue waters of Kal’tsevoe Lake. The Advanced Land Imager (ALI) on NASA’s Earth Observing-1 (EO-1) satellite acquired this true-color image of southern Onekotan on June 10, 2009. In this late-spring shot, snow or ice lingers on the land, forming white streaks on a brown-and-green land surface. In the northwest quadrant of the caldera is Krenitzyn Peak, which rises to a height of 1,325 meters (4,347 feet). Like the other Kuril Islands, Onekotan lies along the Pacific “Ring of Fire.” The Kuril Island volcanoes are fueled by magma generated by the subduction of the Pacific Plate under the Eurasian Plate, which takes place along a deep trench about 200 kilometers (120 miles) to the islands’ east. The only historical eruption at Krenitzyn Peak occurred in 1952, a week after a magnitude 9.0 earthquake along the subduction fault. NASA Earth Observatory image created by Robert Simmon, using EO-1 ALI data provided courtesy of the NASA EO-1 team. Caption by Michon Scott and Rebecca Lindsey. NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Air and wet bulb temperature lapse rates and their impact on snowmaking in a Pyrenean ski resort

NASA Astrophysics Data System (ADS)

López-Moreno, Juan Ignacio; Navarro-Serrano, F.; Azorín-Molina, C.; Sánchez-Navarrete, P.; Alonso-González, E.; Rico, I.; Morán-Tejeda, E.; Buisan, S.; Revuelto, J.; Pons, M.; Vicente-Serrano, S. M.

2018-03-01

A set of 17 air temperature and relative humidity sensors were used to analyze the temporal variability of surface air temperature (Tair), wet bulb temperature (Twb), and daily snowmaking hours (SM, number of hours per day with Twb < - 2 °C), lapse rates, and the occurrence of thermal inversions at the Formigal ski resort (Spanish Pyrenees) from December to March during three consecutive ski seasons (2012-2013, 2013-2014, and 2014-2015). The Tair and Twb lapse rates showed strong hourly and daily variability, with both exhibiting almost identical temporal fluctuations. The Twb exhibited average lapse rates that were slightly steeper (- 5.2 °C/km) than those observed for Tair (- 4.9 °C/km). The less steep lapse rates and most thermal inversions were observed in December. Days having less (more) steep Tair and Twb lapse rates were observed under low (high) wind speeds and high (low) relative humidity and air pressure. The temporal dynamics of the SM lapse rates was more complex, as this involved consideration of the average Tair in the ski resort, in addition to the driving factors of the spatio-temporal variability of Twb. Thus, on a number of cold (warm) days, snowmaking was feasible at all elevations at the ski resort, independently of the slopes of the lapse rates. The SM exhibited an average daily lapse rate of 8.2 h/km, with a progressive trend of increase from December to March. Weather types over the Iberian Peninsula tightly control the driving factors of the Tair, Twb, and SM lapse rates (wind speed, relative humidity, and Tair), so the slopes of the lapse rates and the frequency of inversions in relation to elevation for the three variables are very dependent on the occurrence of specific weather types. The less steep lapse rates occurred associated with advections from the southeast, although low lapse rates also occurred during advections from the east and south, and under anticyclonic conditions. The steepest Tair and Twb lapse rates were observed

Optical manipulation of valley pseudospin

DOE PAGES

Ye, Ziliang; Sun, Dezheng; Heinz, Tony F.

2016-09-19

The coherent manipulation of spin and pseudospin underlies existing and emerging quantum technologies, including quantum communication and quantum computation. Valley polarization, associated with the occupancy of degenerate, but quantum mechanically distinct valleys in momentum space, closely resembles spin polarization and has been proposed as a pseudospin carrier for the future quantum electronics. Valley exciton polarization has been created in the transition metal dichalcogenide monolayers using excitation by circularly polarized light and has been detected both optically and electrically. In addition, the existence of coherence in the valley pseudospin has been identified experimentally. The manipulation of such valley coherence has, however,more » remained out of reach. In this paper, we demonstrate all-optical control of the valley coherence by means of the pseudomagnetic field associated with the optical Stark effect. Using below-bandgap circularly polarized light, we rotate the valley exciton pseudospin in monolayer WSe 2 on the femtosecond timescale. Both the direction and speed of the rotation can be manipulated optically by tuning the dynamic phase of excitons in opposite valleys. Finally, this study unveils the possibility of generation, manipulation, and detection of the valley pseudospin by coupling to photons.« less

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.

PubMed

Ebiloma, Godwin U; Ayuga, Teresa Díaz; Balogun, Emmanuel O; Gil, Lucía Abad; Donachie, Anne; Kaiser, Marcel; Herraiz, Tomás; Inaoka, Daniel K; Shiba, Tomoo; Harada, Shigeharu; Kita, Kiyoshi; de Koning, Harry P; Dardonville, Christophe

2018-04-25

African trypanosomiasis is a neglected parasitic disease that is still of great public health relevance, and a severe impediment to agriculture in endemic areas. The pathogens possess certain unique metabolic features that can be exploited for the development of new drugs. Notably, they rely on an essential, mitochondrially-localized enzyme, Trypanosome Alternative Oxidase (TAO) for their energy metabolism, which is absent in the mammalian hosts and therefore an attractive target for the design of safe drugs. In this study, we cloned, expressed and purified the physiologically relevant form of TAO, which lacks the N-terminal 25 amino acid mitochondrial targeting sequence (ΔMTS-TAO). A new class of 32 cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde inhibitors was designed and synthesized, enabling the first structure-activity relationship studies on ΔMTS-TAO. Remarkably, we obtained compounds with enzyme inhibition values (IC 50 ) as low as 2 nM, which were efficacious against wild type and multidrug-resistant strains of T. brucei and T. congolense. The inhibitors 13, 15, 16, 19, and 30, designed with a mitochondrion-targeting lipophilic cation tail, displayed trypanocidal potencies comparable to the reference drugs pentamidine and diminazene, and showed no cross-resistance with the critical diamidine and melaminophenyl arsenical classes of trypanocides. The cationic inhibitors 15, 16, 19, 20, and 30 were also much more selective (900 - 344,000) over human cells than the non-targeted neutral derivatives (selectivity >8-fold). A preliminary in vivo study showed that modest doses of 15 and 16 reduced parasitaemia of mice infected with T. b. rhodesiense (STIB900). These compounds represent a promising new class of potent and selective hits against African trypanosomes. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

The Use of Body Worn Sensors for Detecting the Vibrations Acting on the Lower Back in Alpine Ski Racing.

PubMed

Spörri, Jörg; Kröll, Josef; Fasel, Benedikt; Aminian, Kamiar; Müller, Erich

2017-01-01

This study explored the use of body worn sensors to evaluate the vibrations that act on the human body in alpine ski racing from a general and a back overuse injury prevention perspective. In the course of a biomechanical field experiment, six male European Cup-level athletes each performed two runs on a typical giant slalom (GS) and slalom (SL) course, resulting in a total of 192 analyzed turns. Three-dimensional accelerations were measured by six inertial measurement units placed on the right and left shanks, right and left thighs, sacrum, and sternum. Based on these data, power spectral density (PSD; i.e., the signal's power distribution over frequency) was determined for all segments analyzed. Additionally, as a measure expressing the severity of vibration exposure, root-mean-square (RMS) acceleration acting on the lower back was calculated based on the inertial acceleration along the sacrum's longitudinal axis. In both GS and SL skiing, the PSD values of the vibrations acting at the shank were found to be largest for frequencies below 30 Hz. While being transmitted through the body, these vibrations were successively attenuated by the knee and hip joint. At the lower back (i.e., sacrum sensor), PSD values were especially pronounced for frequencies between 4 and 10 Hz, whereas a corresponding comparison between GS and SL revealed higher PSD values and larger RMS values for GS. Because vibrations in this particular range (i.e., 4 to 10 Hz) include the spine's resonant frequency and are known to increase the risk of structural deteriorations/abnormalities of the spine, they may be considered potential components of mechanisms leading to overuse injuries of the back in alpine ski racing. Accordingly, any measure to control and/or reduce such skiing-related vibrations to a minimum should be recognized and applied. In this connection, wearable sensor technologies might help to better monitor and manage the overall back overuse-relevant vibration exposure of athletes

Chuckwalla Valley multiple-well monitoring site, Chuckwalla Valley, Riverside County

USGS Publications Warehouse

Everett, Rhett

2013-01-01

The U.S. Geological Survey (USGS), in cooperation with the Bureau of Land Management, is evaluating the geohydrology and water availability of the Chuckwalla Valley, California. As part of this evaluation, the USGS installed the Chuckwalla Valley multiple-well monitoring site (CWV1) in the southeastern portion of the Chuckwalla Basin. Data collected at this site provide information about the geology, hydrology, geophysics, and geochemistry of the local aquifer system, thus enhancing the understanding of the geohydrologic framework of the Chuckwalla Valley. This report presents construction information for the CWV1 multiple-well monitoring site and initial geohydrologic data collected from the site.

Sacramento Valley, CA, USA

NASA Technical Reports Server (NTRS)

1973-01-01

The Sacramento Valley (40.5N, 121.5W) of California is the northern extension of the Central Valley, main agriculture region of the state. Hundreds of truck farms, vineyards and orchards can be seen throughout the length and breadth of the valley which was reclaimed from the desert by means of intensive and extensive irrigation projects.

Nutrient status in soil of Ski runs in the sub-alpine belt of Uludag Mountain, Bursa, Turkey.

PubMed

Guleryuz, Gurcan; Kirmizi, Serap; Arslan, Hulya

2010-01-01

Large areas of land are disturbed in sensitive bio-diverse mountain environments by Skiruns. Restoration of vegetation on such disturbed mountain sites may be hampered by soil degradation but the severity and nature of the constraints is not well understood. This study was designed to compare the water holding and nutritional status of soil in three Ski runs which had different construction dates and disturbance levels, and the adjacent undisturbed site in the Abies bommuelleriana forest community in the sub-alpine belt of Uludag Mountain (Bithynian Olympus). The values of soil parameters were depressed in proportion to the disturbance level. Water holding capacity (WHC), total nitrogen (N), organic carbon (C) and calcium (Ca2+), magnesium (Mg2+) and potassium (K+) contents (mg kg(-1) dry weight) of soils in the Ski run which had the highest disturbance level were lower than that of the undisturbed adjacent sites. However the results indicated that the soil parameters were less degraded when secondary vegetation was growing on the disturbed areas.

The environmental conditionings of the location of primeval settlements in the Wieprz River valley

NASA Astrophysics Data System (ADS)

Kozieł, Marcin; Kozieł, Wojciech

2012-01-01

The Wieprz River along the section currently occupied by the Nadwieprzański Landscape Park (NLP) constituted a convenient place of human settlement from the moment of retreat of the last ice sheet. Depending on the types of economy preferred by representatives of individual archaeological cultures, the river valley from Spiczyn to Dorohucza offered continuous access to water. This obviously gained additional importance from the moment of appearance of Neolithic cultures, particularly the Globular Amphora culture and Corded Ware culture with semi-nomadic style of life, dealing with breeding. Neolithic hunters-gatherers exploited the animal resources available in the river and its vicinity. The further role of fishing, i.e. providing a diet element or supplementation already in the conditions of agricultural-breeding economy, seems to be evidenced by findings of fishing hooks at Lusatian and Wielbark sites. Another factor affecting the location of settlements in NLP was also its close vicinity to the crops of the Rejowiec flint. According to archaeologists, this is particularly obvious in the case of the Late Palaeolithic and the turn of the Neolithic and Bronze Age. The communication function of the river could also be of importance: in the case of seasonal animal migrations of animals and hunters (Late Palaeolithic); livestock and shepherds (Globular Amphora culture and Corded Ware culture); or people alone (migration of the population of the Wielbark culture to the Red Sea). The fact that a commercial trail fragment was located along the Wieprz River is probably evidenced by the abundance of import from various parts of Europe at site 53 in Spiczyn. Fertile soils (black soils, silt-peat soils) prevailing in the valley also favoured the settlement of cultures with an agricultural-breeding model of economy, providing good conditions for horticulture. Meadows near the river could be used as pastures.

Heart rate profiles and energy cost of locomotion during cross-country skiing races.

PubMed

Mognoni, P; Rossi, G; Gastaldelli, F; Canclini, A; Cotelli, F

2001-07-01

The purpose of this study was to compare heart rate responses and speed in two cross-country skiing races, which were run by seven male and seven female subjects by using classic and free style. Heart rates and skiing velocities were analyzed over flat, uphill and downhill sections, which were run from one to three times. Heart rates were higher in uphill sections than in flat sections; a steady-state heart rate was never reached in the downhill section. When the same uphill section was repeated, the heart rate tended to increase but the speed to decrease. Oxygen uptake (VO2) was calculated from heart rate:VO2 ratio, measured during uphill walking with the aid of poles. The mean (SD) energy cost of locomotion (i.e., the ratio between net VO2 and speed) was 162.1 (9.4) ml.km(-1).kg(-1) and 147.7 (7.1) ml.km(-1).kg(-1) when male subjects ran the flat section after first downhill by using classic and free style, respectively. Females had lower values for VO2 and speed, but similar energy costs. In general, the variability of the energy cost of locomotion in skiers of a similar competitive level is of the same order as that found in uphill walking on a treadmill.

Sierra Nevada, California

NASA Image and Video Library

1994-09-30

STS068-267-097 (30 September-11 October 1994) --- An extensive view eastward from the irrigated San Joaquin Valley in the foreground, across the Sierra Nevada (living up to its name in early October), into the desert of eastern California and Nevada (which has no snow, despite the name). Mono Lake is just visible at the left edge of the frame; Owens Valley extends southward to Owens Lake, the next valley is Panamint Valley, and then Death Valley. Las Vegas and Lake Mead are visible at the upper right of the frame. The Space Radar Laboratory 2 (SRL-2) obtained extensive, multiple-pass data from many test sites within the region displayed, including Mammoth Mountain ski area south of Mono Lake, and in Death Valley.

Maturity status influences the relative age effect in national top level youth alpine ski racing and soccer

PubMed Central

Müller, Lisa; Gonaus, Christoph; Perner, Christoph; Müller, Erich; Raschner, Christian

2017-01-01

Since the relative age effect (RAE) characterizes a problem in all age categories of alpine ski racing and soccer and the fact that, yet, to date the underlying factors have not been well investigated, the aim of the present study was to assess the influence of the biological maturity status on the RAE among youth alpine ski racers (YSR) and soccer players (SP). In total, 183 male and female YSR selected for national final races and 423 male SP selected for Elite Youth Development Centres were investigated. Additionally, a comparison group of 413 non-athletes was evaluated. The birth months were split into four relative age quarters. The biological maturity status was assessed by the age at peak height velocity (APHV) method; according to the M±SD of the comparison group, the athletes were divided into normal, early and late maturing. Chi2-tests indicated a significant RAE among YSR (χ2(3,N = 183) = 18.0; p<0.001; ω = 0.31) and SP (χ2(3,N = 423) = 33.1; p<0.001; ω = 0.28). In total, only a small number of late maturing athletes were present (0.5–2.3%). Among relatively younger athletes, high percentages of early maturing athletes were found (43.1–43.3%). The findings indicate that relatively younger and less mature athletes are marginalized or totally excluded in alpine ski racing and soccer. Thus, selection criteria in both sports are effectively based on early biological development and relatively older age, both of which should be considered in future in the talent selection process. In this context, the easy feasible method of assessing the APHV can be used. PMID:28759890

Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.

PubMed

Reyes-Gordillo, Karina; Shah, Ruchi; Arellanes-Robledo, Jaime; Hernández-Nazara, Zamira; Rincón-Sánchez, Ana Rosa; Inagaki, Yutaka; Rojkind, Marcos; Lakshman, M Raj

2014-05-01

Alcohol-induced liver fibrosis and eventually cirrhosis is a leading cause of death. Acetaldehyde, the first metabolite of ethanol, up-regulates expression of the human α2(I) collagen gene (COL1A2). Early acetaldehyde-mediated effects involve phosphorylation and nuclear translocation of SMAD3/4-containing complexes that bind to COL1A2 promoter to induce fibrogenesis. We used human and mouse hepatic stellate cells to elucidate the mechanisms whereby acetaldehyde up-regulates COL1A2 by modulating the role of Ski and the expression of SMADs 3, 4, and 7. Acetaldehyde induced up-regulation of COL1A2 by 3.5-fold, with concomitant increases in the mRNA (threefold) and protein (4.2- and 3.5-fold) levels of SMAD3 and SMAD4, respectively. It also caused a 60% decrease in SMAD7 expression. Ski, a member of the Ski/Sno oncogene family, is colocalized in the nucleus with SMAD4. Acetaldehyde induces translocation of Ski and SMAD4 to the cytoplasm, where Ski undergoes proteasomal degradation, as confirmed by the ability of the proteasomal inhibitor lactacystin to blunt up-regulation of acetaldehyde-dependent COL1A2, but not of the nonspecific fibronectin gene (FN1). We conclude that acetaldehyde up-regulates COL1A2 by enhancing expression of the transactivators SMAD3 and SMAD4 while inhibiting the repressor SMAD7, along with promoting Ski translocation from the nucleus to cytoplasm. We speculate that drugs that prevent proteasomal degradation of repressors targeting COL1A2 may have antifibrogenic properties. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Sacramento Valley, CA, USA

NASA Image and Video Library

1973-06-22

SL2-04-179 (22 June 1973) --- The Sacramento Valley (40.5N, 121.5W) of California is the northern extension of the Central Valley, main agriculture region of the state. Hundreds of truck farms, vineyards and orchards can be seen throughout the length and breadth of the valley which was reclaimed from the desert by means of intensive and extensive irrigation projects. Photo credit: NASA

Observation of acoustic valley vortex states and valley-chirality locked beam splitting

NASA Astrophysics Data System (ADS)

Ye, Liping; Qiu, Chunyin; Lu, Jiuyang; Wen, Xinhua; Shen, Yuanyuan; Ke, Manzhu; Zhang, Fan; Liu, Zhengyou

2017-05-01

We report an experimental observation of the classical version of valley polarized states in a two-dimensional hexagonal sonic crystal. The acoustic valley states, which carry specific linear momenta and orbital angular momenta, were selectively excited by external Gaussian beams and conveniently confirmed by the pressure distribution outside the crystal, according to the criterion of momentum conservation. The vortex nature of such intriguing bulk crystal states was directly characterized by scanning the phase profile inside the crystal. In addition, we observed a peculiar beam-splitting phenomenon, in which the separated beams are constructed by different valleys and locked to the opposite vortex chirality. The exceptional sound transport, encoded with valley-chirality locked information, may serve as the basis of designing conceptually interesting acoustic devices with unconventional functions.

The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors.

PubMed

Pasquato, Antonella; Pullikotil, Philomena; Asselin, Marie-Claude; Vacatello, Manuela; Paolillo, Livio; Ghezzo, Francesca; Basso, Federica; Di Bello, Carlo; Dettin, Monica; Seidah, Nabil G

2006-08-18

Herein we designed, synthesized, tested, and validated fluorogenic methylcoumarinamide (MCA) and chloromethylketone-peptides spanning the Lassa virus GPC cleavage site as substrates and inhibitors for the proprotein convertase SKI-1/S1P. The 7-mer MCA (YISRRLL-MCA) and 8-mer MCA (IYISRRLL-MCA) are very efficiently cleaved with respect to both the 6-mer MCA (ISRRLL-MCA) and point mutated fluorogenic analogues, except for the 7-mer mutant Y253F. The importance of the P7 phenylic residue was confirmed by digestions of two 16-mer non-fluorogenic peptidyl substrates that differ by a single point mutation (Y253A). Because NMR analysis of these 16-mer peptides did not reveal significant structural differences at recognition motif RRLL, the P7 Tyr residue is likely important in establishing key interactions within the catalytic pocket of SKI-1. Based on these data, we established through analysis of pro-ATF6 and pro-SREBP-2 cellular processing that decanoylated chloromethylketone 7-mer, 6-mer, and 4-mer peptides containing the core RRLL sequence are irreversible and potent ex vivo SKI-1 inhibitors. Although caution must be exercised in using these inhibitors in in vitro reactions, as they can also inhibit the basic amino acid-specific convertase furin, within cells and when used at concentrations < or = 100 microM these inhibitors are relatively specific for inhibition of SKI-1 processing events, as opposed to those performed by furin-like convertases.

Dry Valleys, Antarctica

NASA Image and Video Library

2009-11-02

The McMurdo Dry Valleys are a row of valleys west of McMurdo Sound, Antarctica. They are so named because of their extremely low humidity and lack of snow and ice cover. This image was acquired December 8, 2002 by NASA Terra spacecraft.

Ground-water conditions in southern Utah Valley and Goshen Valley, Utah

USGS Publications Warehouse

Cordova, R.M.

1970-01-01

The investigation of ground-water conditions in southern Utah Valley and Goshen Valley, Utah, was made by the U. S. Geological Survey as part of a cooperative program with the Utah Department of Natural Resources, Division of Water Rights, to investigate the water resources of the State. The purposes of the investigation were to (1) determine the occurrence, recharge, discharge, movement, storage, chemical quality, and availability of ground water; (2) appraise the effects of increased withdrawal of water from wells; and (3) evaluate the effect of the Central Utah Project on the ground-water reservoir and the water supply of Utah Lake.This report presents a description of the aquifer system in the two valleys, a detailed description of the ground-water resources, and conclusions about potential development and its effect on the hydrologic conditions in the valleys. Two supplementary reports are products of the investigation. A basic-data release (Cordova, 1969) contains most of the basic data collected for the investigation, including well characteristics, drillers' logs, water levels, pumpage from wells, chemical analyses of ground and surface waters, and discharge of selected springs, drains, and streams. An interpretive report (Cordova and Mower, 1967) contains the results of a large-scale aquifer test in southern Utah Valley.

The SKI*HI Model: Programming for Hearing Impaired Infants through Home Intervention, Home Visit Curriculum. Fourth Edition.

ERIC Educational Resources Information Center

Clark, Thomas C.; Watkins, Susan

The manual describes the SKI*HI Model, a comprehensive approach to identification and home intervention treatment of hearing impaired children and their families. The model features home programing in four basic areas: the home hearing aid program (nine lessons which facilitate the proper fit and acceptance of amplification by the child), home…

Analysis of Mining-induced Valley Closure Movements

NASA Astrophysics Data System (ADS)

Zhang, C.; Mitra, R.; Oh, J.; Hebblewhite, B.

2016-05-01

Valley closure movements have been observed for decades in Australia and overseas when underground mining occurred beneath or in close proximity to valleys and other forms of irregular topographies. Valley closure is defined as the inward movements of the valley sides towards the valley centreline. Due to the complexity of the local geology and the interplay between several geological, topographical and mining factors, the underlying mechanisms that actually cause this behaviour are not completely understood. A comprehensive programme of numerical modelling investigations has been carried out to further evaluate and quantify the influence of a number of these mining and geological factors and their inter-relationships. The factors investigated in this paper include longwall positional factors, horizontal stress, panel width, depth of cover and geological structures around the valley. It is found that mining in a series passing beneath the valley dramatically increases valley closure, and mining parallel to valley induces much more closure than other mining orientations. The redistribution of horizontal stress and influence of mining activity have also been recognised as important factors promoting valley closure, and the effect of geological structure around the valley is found to be relatively small. This paper provides further insight into both the valley closure mechanisms and how these mechanisms should be considered in valley closure prediction models.

The Inter-Valley Soil Comparative Survey: the ecology of Dry Valley edaphic microbial communities

PubMed Central

Lee, Charles K; Barbier, Béatrice A; Bottos, Eric M; McDonald, Ian R; Cary, Stephen Craig

2012-01-01

Recent applications of molecular genetics to edaphic microbial communities of the McMurdo Dry Valleys and elsewhere have rejected a long-held belief that Antarctic soils contain extremely limited microbial diversity. The Inter-Valley Soil Comparative Survey aims to elucidate the factors shaping these unique microbial communities and their biogeography by integrating molecular genetic approaches with biogeochemical analyses. Although the microbial communities of Dry Valley soils may be complex, there is little doubt that the ecosystem's food web is relatively simple, and evidence suggests that physicochemical conditions may have the dominant role in shaping microbial communities. To examine this hypothesis, bacterial communities from representative soil samples collected in four geographically disparate Dry Valleys were analyzed using molecular genetic tools, including pyrosequencing of 16S rRNA gene PCR amplicons. Results show that the four communities are structurally and phylogenetically distinct, and possess significantly different levels of diversity. Strikingly, only 2 of 214 phylotypes were found in all four valleys, challenging a widespread assumption that the microbiota of the Dry Valleys is composed of a few cosmopolitan species. Analysis of soil geochemical properties indicated that salt content, alongside altitude and Cu2+, was significantly correlated with differences in microbial communities. Our results indicate that the microbial ecology of Dry Valley soils is highly localized and that physicochemical factors potentially have major roles in shaping the microbiology of ice-free areas of Antarctica. These findings hint at links between Dry Valley glacial geomorphology and microbial ecology, and raise previously unrecognized issues related to environmental management of this unique ecosystem. PMID:22170424

27 CFR 9.132 - Rogue Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Rogue Valley. 9.132... Rogue Valley. (a) Name. The name of the viticultural area described in this section is “Rouge Valley.” (b) Approved map. The appropriate map for determining the boundaries of the Rogue Valley viticultural...

Individual flight styles in ski jumping: results obtained during Olympic Games competitions.

PubMed

Schmölzer, B; Müller, W

2005-05-01

From the physics point of view, the jump length in ski jumping depends on: the in-run velocity v(0), the velocity perpendicular to the ramp v(p0) due to the athlete's jumping force, the lift and drag forces acting during take-off and during the flight, and the weight of the athlete and his equipment. The aerodynamic forces are a function of the flight position and of the equipment features. They are a predominant performance factor and can largely be influenced by the athlete. The field study conducted during the Olympic Games competitions 2002 at Park City (elevation: 2000 m) showed an impressive ability of the Olympic medallists to reproduce their flight style and remarkable differences between different athletes have been found. The aerodynamic forces are proportional to the air density. Elite athletes are able to adapt their flight style to thin air conditions in order to maximise jump length and to keep the flight stable. The effects of flight position variations on the performance have been analysed by means of a computer model which is based on the equations of motion and on wind tunnel data corresponding to the flight positions found in the field. Athletes have to solve extremely difficult optimisation problems within fractions of a second. The computer simulation can be used as a reliable starting point for the improvement of training methods and gives an insight into the "implicit" knowledge of physics that the ski jumping athlete must have available for a good performance.

Characterization of Course and Terrain and Their Effect on Skier Speed in World Cup Alpine Ski Racing

PubMed Central

Gilgien, Matthias; Crivelli, Philip; Spörri, Jörg; Kröll, Josef; Müller, Erich

2015-01-01

World Cup (WC) alpine ski racing consists of four main competition disciplines (slalom, giant slalom, super-G and downhill), each with specific course and terrain characteristics. The International Ski Federation (FIS) has regulated course length, altitude drop from start to finish and course setting in order to specify the characteristics of the respective competition disciplines and to control performance and injury-related aspects. However to date, no detailed data on course setting and its adaptation to terrain is available. It is also unknown how course and terrain characteristics influence skier speed. Therefore, the aim of the study was to characterize course setting, terrain geomorphology and their relationship to speed in male WC giant slalom, super-G and downhill. The study revealed that terrain was flatter in downhill compared to the other disciplines. In all disciplines, variability in horizontal gate distance (gate offset) was larger than in gate distance (linear distance from gate to gate). In giant slalom the horizontal gate distance increased with terrain inclination, while super-G and downhill did not show such a connection. In giant slalom and super-G, there was a slight trend towards shorter gate distances as the steepness of the terrain increased. Gates were usually set close to terrain transitions in all three disciplines. Downhill had a larger proportion of extreme terrain inclination changes along the skier trajectory per unit time skiing than the other disciplines. Skier speed decreased with increasing steepness of terrain in all disciplines except for downhill. In steep terrain, speed was found to be controllable by increased horizontal gate distances in giant slalom and by shorter gate distances in giant slalom and super-G. Across the disciplines skier speed was largely explained by course setting and terrain inclination in a multiple linear model. PMID:25760039

Questa Baseline and Pre-Mining Ground-Water Quality Investigation. 25. Summary of Results and Baseline and Pre-Mining Ground-Water Geochemistry, Red River Valley, Taos County, New Mexico, 2001-2005

USGS Publications Warehouse

Nordstrom, D. Kirk

2008-01-01

Active and inactive mine sites are challenging to remediate because of their complexity and scale. Regulations meant to achieve environmental restoration at mine sites are equally challenging to apply for the same reasons. The goal of environmental restoration should be to restore contaminated mine sites, as closely as possible, to pre-mining conditions. Metalliferous mine sites in the Western United States are commonly located in hydrothermally altered and mineralized terrain in which pre-mining concentrations of metals were already anomalously high. Typically, those pre-mining concentrations were not measured, but sometimes they can be reconstructed using scientific inference. Molycorp?s Questa molybdenum mine in the Red River Valley, northern New Mexico, is located near the margin of the Questa caldera in a highly mineralized region. The State of New Mexico requires that ground-water quality standards be met on closure unless it can be shown that potential contaminant concentrations were higher than the standards before mining. No ground water at the mine site had been chemically analyzed before mining. The aim of this investigation, in cooperation with the New Mexico Environment Department (NMED), is to infer the pre-mining ground-water quality by an examination of the geologic, hydrologic, and geochemical controls on ground-water quality in a nearby, or proximal, analog site in the Straight Creek drainage basin. Twenty-seven reports contain details of investigations on the geological, hydrological, and geochemical characteristics of the Red River Valley that are summarized in this report. These studies include mapping of surface mineralogy by Airborne Visible-Infrared Imaging Spectrometry (AVIRIS); compilations of historical surface- and ground- water quality data; synoptic/tracer studies with mass loading and temporal water-quality trends of the Red River; reaction-transport modeling of the Red River; environmental geology of the Red River Valley; lake

Differences in food intake and nutritional habits between Spanish adolescents who engage in ski activity and those who do not.

PubMed

Mariscal-Arcas, Miguel; Monteagudo, Celia; Hernandez-Elizondo, Jessenia; Benhammou, Samira; Lorenzo, M Luisa; Olea-Serrano, Fatima

2014-10-31

Increasing obesity among adolescents in the industrialized world may result from poor nutritional habits and inadequate exercise. To determine differences in food intake, nutritional habits, and body mass index between Spanish adolescents who engage in ski activity and those who do not. A socio-demographic survey, food frequency questionnaire, 24-hr dietary recall, and physical activity questionnaire were completed by 300 Spanish schoolchildren aged 10 to 18 yrs. RESULTS were compared (Student's t, chi-square and Fisher's exact test) between adolescents engaged (SP) and not engaged (N-SP) in skiing according to their sex. SP adolescents devoted > 4 h/day to physical activity versus < 1 h for N-SP adolescents. No significant differences were found in nutrient intake or nutritional habits between SP and N-SP adolescents. Protein and fat intakes of both groups were above recommended levels. A higher proportion of N-SP than SP males were overweight. Logistic regression analysis showed that the maintenance of a normal weight was favored by the practice of skiing, the consumption of sugar-free drinks, and supplementation with vitamins/mineral salts and was negatively associated with body weight dissatisfaction, intake of nutritional supplements other than vitamins or minerals, and the consumption of snacks. The diet of this adolescent population was poorly balanced. Engagement in physical activity appears to be a key factor in maintaining a healthy body mass index. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Comparing the impacts of hiking, skiing and horse riding on trail and vegetation in different types of forest.

PubMed

Törn, A; Tolvanen, A; Norokorpi, Y; Tervo, R; Siikamäki, P

2009-03-01

Nature-based tourism in protected areas has increased and diversified dramatically during the last decades. Different recreational activities have a range of impacts on natural environments. This paper reports results from a comparison of the impacts of hiking, cross-country skiing and horse riding on trail characteristics and vegetation in northern Finland. Widths and depths of existing trails, and vegetation on trails and in the neighbouring forests were monitored in two research sites during 2001 and 2002. Trail characteristics and vegetation were clearly related to the recreational activity, research site and forest type. Horse trails were as deep as hiking trails, even though the annual number of users was 150-fold higher on the hiking trails. Simultaneously, cross-country skiing had the least effect on trails due to the protective snow cover during winter. Hiking trail plots had little or no vegetation cover, horse riding trail plots had lower vegetation cover than forest plots, while skiing had no impact on total vegetation cover. On the other hand, on horse riding trails there were more forbs and grasses, many of which did not grow naturally in the forest. These species that were limited to riding trails may change the structure of adjacent plant communities in the long run. Therefore, the type of activities undertaken and the sensitivity of habitats to these activities should be a major consideration in the planning and management of nature-based tourism. Establishment of artificial structures, such as stairs, duckboards and trail cover, or complete closure of the site, may be the only way to protect the most sensitive or deteriorated sites.

Hydrogeologic framework and estimates of groundwater storage for the Hualapai Valley, Detrital Valley, and Sacramento Valley basins, Mohave County, Arizona

USGS Publications Warehouse

Truini, Margot; Beard, L. Sue; Kennedy, Jeffrey; Anning, Dave W.

2013-01-01

We have investigated the hydrogeology of the Hualapai Valley, Detrital Valley, and Sacramento Valley basins of Mohave County in northwestern Arizona to develop a better understanding of groundwater storage within the basin fill aquifers. In our investigation we used geologic maps, well-log data, and geophysical surveys to delineate the sedimentary textures and lithology of the basin fill. We used gravity data to construct a basin geometry model that defines smaller subbasins within the larger basins, and airborne transient-electromagnetic modeled results along with well-log lithology data to infer the subsurface distribution of basin fill within the subbasins. Hydrogeologic units (HGUs) are delineated within the subbasins on the basis of the inferred lithology of saturated basin fill. We used the extent and size of HGUs to estimate groundwater storage to depths of 400 meters (m) below land surface (bls). The basin geometry model for the Hualapai Valley basin consists of three subbasins: the Kingman, Hualapai, and southern Gregg subbasins. In the Kingman subbasin, which is estimated to be 1,200 m deep, saturated basin fill consists of a mixture of fine- to coarse-grained sedimentary deposits. The Hualapai subbasin, which is the largest of the subbasins, contains a thick halite body from about 400 m to about 4,300 m bls. Saturated basin fill overlying the salt body consists predominately of fine-grained older playa deposits. In the southern Gregg subbasin, which is estimated to be 1,400 m deep, saturated basin fill is interpreted to consist primarily of fine- to coarse-grained sedimentary deposits. Groundwater storage to 400 m bls in the Hualapai Valley basin is estimated to be 14.1 cubic kilometers (km3). The basin geometry model for the Detrital Valley basin consists of three subbasins: northern Detrital, central Detrital, and southern Detrital subbasins. The northern and central Detrital subbasins are characterized by a predominance of playa evaporite and fine

Enhancer‐promoter Activity of Human Papillomavirus Type 16 Long Control Regions Isolated from Cell Lines SiHa and CaSki and Cervical Cancer Biopsies

PubMed Central

Kozuka, Takuyo; Aoki, Yukimasa; Nakagawa, Keiichi; Ohtomo, Kuni; Yoshikawa, Hiroyuki; Matsumoto, Koji; Yoshiike, Kunito

2000-01-01

Expression of human papillomavirus 16 (HPV‐16) oncogenes is markedly higher in cervical cancer cells than in precancerous cells, and the elevated expression is believed to be required for the malignant phenotypes. We compared cancer cell lines CaSki (with 200 to 400 copies of HPV‐16 DNA per cell) and SiHa (with one to two copies of HPV‐16 DNA per cell) for the E7 expression in cells and the enhancer‐promoter activity of the isolated viral long control region (LCR). Although these parameters per cell were 10‐fold higher in CaSki than in SiHa, the levels of the E7 mRNA and protein per HPV DNA copy were 10‐ to 20‐fold higher in SiHa than in CaSki. Characterization of the isolated LCRs showed that, whereas the LCR from CaSki resembled the prototype in structure and activity, the LCR from SiHa, with a deletion of 38 base pairs, enhanced transcription from P97 as assayed by using a plasmid capable of expressing luciferase. The upregulation appeared to be due to removal of one of the silencer YY1‐binding sites. Furthermore, we isolated and characterized LCRs from 51 cervical cancer patients’ biopsies. Among them, one with a deletion including YY1‐binding sites and the other with a substitution in a YY1‐motif were found to enhance the transcription. These findings suggest that mutation affecting YY1‐motifs in the LCR is one of the mechanisms enhancing the viral oncogene expression in the course of progression of cancer cells. PMID:10760685

Fretted Terrain Valleys

NASA Technical Reports Server (NTRS)

2004-01-01

30 October 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows shallow tributary valleys in the Ismenius Lacus fretted terrain region of northern Arabia Terra. These valleys exhibit a variety of typical fretted terrain valley wall and floor textures, including a lineated, pitted material somewhat reminiscent of the surface of a brain. Origins for these features are still being debated within the Mars science community; there are no clear analogs to these landforms on Earth. This image is located near 39.9oN, 332.1oW. The picture covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the lower left.

78 FR 39608 - Safety Zone; Summer in the City Water Ski Show; Fox River, Green Bay, WI

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

...-AA00 Safety Zone; Summer in the City Water Ski Show; Fox River, Green Bay, WI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the Fox River in Green Bay, WI. This safety zone is intended to restrict vessels from a portion of the Fox River...

SKI*HI Home-Based Programming for Children with Hearing Impairments: Demographics, Child Identification, and Program Effectiveness, 1979-1991.

ERIC Educational Resources Information Center

Strong, Carol J.; And Others

SKI*HI is a program designed to identify children with hearing impairments as early as possible and to provide them and their families with complete home programming that will facilitate development. The delivery model includes identification/screening services, home visit services, support services, and program management. A parent advisor makes…

Preliminary geologic map of the Big Costilla Peak area, Taos County, New Mexico, and Costilla County, Colorado

USGS Publications Warehouse

Fridrich, Christopher J.; Shroba, Ralph R.; Hudson, Adam M.

2012-01-01

This map covers the Big Costilla Peak, New Mex.&nash;Colo. quadrangle and adjacent parts of three other 7.5 minute quadrangles: Amalia, New Mex.–Colo., Latir Peak, New Mex., and Comanche Point, New Mex. The study area is in the southwesternmost part of that segment of the Sangre de Cristo Mountains known as the Culebra Range; the Taos Range segment lies to the southwest of Costilla Creek and its tributary, Comanche Creek. The map area extends over all but the northernmost part of the Big Costilla horst, a late Cenozoic uplift of Proterozoic (1.7-Ga and less than 1.4-Ga) rocks that is largely surrounded by down-faulted middle to late Cenozoic (about 40 Ma to about 1 Ma) rocks exposed at significantly lower elevations. This horst is bounded on the northwest side by the San Pedro horst and Culebra graben, on the northeast and east sides by the Devils Park graben, and on the southwest side by the (about 30 Ma to about 25 Ma) Latir volcanic field. The area of this volcanic field, at the north end of the Taos Range, has undergone significantly greater extension than the area to the north of Costilla Creek. The horsts and grabens discussed above are all peripheral structures on the eastern flank of the San Luis basin, which is the axial part of the (about 26 Ma to present) Rio Grande rift at the latitude of the map. The Raton Basin lies to the east of the Culebra segment of the Sangre de Cristo Mountains. This foreland basin formed during, and is related to, the original uplift of the Sangre de Cristo Mountains which was driven by tectonic contraction of the Laramide (about 70 Ma to about 40 Ma) orogeny. Renewed uplift and structural modification of these mountains has occurred during formation of the Rio Grande rift. Surficial deposits in the study area include alluvial, mass-movement, and glacial deposits of middle Pleistocene to Holocene age.

Geologic history of the Yosemite Valley

USGS Publications Warehouse

Matthes, Francois E.

1930-01-01

Projection of the longitudinal profiles of these hanging valleys forward to the axis of the Merced Canyon shows that they are closely accordant in height. Their profiles indicate a series of points on a former profile of the Merced with respect to which the side streams had graded their courses prior to the last uplift. This old profile can be extended upward into the glaciated part of the Merced Canyon above El Portal and even into the profoundly glaciated Yosemite Valley, accordant points being furnished by a number of hanging side valleys (due allowance being made for glacial erosion suffered by those valleys). However, not all the hanging valleys of the Yosemite region are accordant with this set. Several of them, including the upland valley of Yosemite Creek, constitute a separate set indicating another old profile of the Merced at a level 600 to 1,000 feet higher than the first. Others, including the hanging gulch of lower Bridalveil Creek, point to an old profile of the Merced about 1,200 feet lower than the first. There are thus three distinct sets of hanging valleys produced in three cycles of stream erosion. The valleys of the upper set, like those of the middle set, were left hanging as a result of rapid trenching by the Merced induced by an uplift of the range, there having been two such uplifts. Only the valleys of the lower set hang because of glacial deepening and widening of the Yosemite Valley, the cycle in which they were cut having been interrupted by the advent of the Pleistocene glaciers. They consequently indicate the preglacial depth of the Yosemite Valley. That depth, measured from the brow of El Capitan, was about 2,400 feet; measured from the rim at Glacier Point it was about 2,000 feet.

76 FR 22746 - Conecuh Valley Railway, LLC-Acquisition and Operation Exemption-Conecuh Valley Railroad Co., Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-22

... Railway, LLC--Acquisition and Operation Exemption--Conecuh Valley Railroad Co., Inc. Conecuh Valley Railway, LLC (CVR), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 to acquire from Conecuh Valley Railroad Co., Inc. (COEH), and to operate [[Page 22747

Conundrums in the legal protection of migrant workers' health rights and relative resolutions: implications from the case of Tseng Hei-tao.

PubMed

Liu, Kai

2013-08-01

The deteriorating situation of migrant workers' health rights protection was once again highlighted in the case of Tseng Hei-tao. This case explicitly and implicitly showed that four conundrums--the Employment Restriction Conundrum, the Occupational Safety and Health (OSH) Legal Conundrum, the Morality Conundrum and the Identity Conundrum--are barriers to migrant workers' right protection. The health rights of migrant workers could be safeguarded by abolishing the outdated household registration system designed in the planned economy era, improving the rule of law, and strengthening administrative supervisions. This would fundamentally remove these barriers and thus contribute to migrant workers' health rights protection.

Grizzly Valley fault system, Sierra Valley, CA

USGS Publications Warehouse

Gold, Ryan; Stephenson, William; Odum, Jack; Briggs, Rich; Crone, Anthony; Angster, Steve

2012-01-01

The Grizzly Valley fault system (GVFS) strikes northwestward across Sierra Valley, California and is part of a network of active, dextral strike-slip faults in the northern Walker Lane (Figure 1). To investigate Quaternary motion across the GVFS, we analyzed high-resolution (0.25 m) airborne LiDAR data (Figure 2) in combination with six, high-resolution, P-wave, seismic-reflection profiles [Gold and others, 2012]. The 0.5- to 2.0-km-long seismic-reflection profiles were sited orthogonal to suspected tectonic lineaments identified from previous mapping and our analysis of airborne LiDAR data. To image the upper 400–700 m of subsurface stratigraphy of Sierra Valley (Figure 3), we used a 230-kg accelerated weight drop source. Geophone spacing ranged from 2 to 5 m and shots were co-located with the geophones. The profiles reveal a highly reflective, deformed basal marker that we interpret to be the top of Tertiary volcanic rocks, overlain by a 120- to 300-m-thick suite of subhorizontal reflectors we interpret as Plio-Pleistocene lacustrine deposits. Three profiles image the principle active trace of the GVFS, which is a steeply dipping fault zone that offsets the volcanic rocks and the basin fill (Figures 4 & 5).

Topological Valley Currents in Gapped Dirac Materials

NASA Astrophysics Data System (ADS)

Lensky, Yuri D.; Song, Justin C. W.; Samutpraphoot, Polnop; Levitov, Leonid S.

2015-06-01

Gapped 2D Dirac materials, in which inversion symmetry is broken by a gap-opening perturbation, feature a unique valley transport regime. Topological valley currents in such materials are dominated by bulk currents produced by electronic states just beneath the gap rather than by edge modes. The system ground state hosts dissipationless persistent valley currents existing even when topologically protected edge modes are absent. Valley currents induced by an external bias are characterized by a quantized half-integer valley Hall conductivity. The undergap currents dominate magnetization and the charge Hall effect in a light-induced valley-polarized state.

Field Surveys, IOC Valleys. Volume III, Part II. Cultural Resources Survey, Pine and Wah Wah Valleys, Utah.

DTIC Science & Technology

1981-08-01

valleys are typical of the Basin and Range Province, characterized by parallel, north-south trending mountain ranges, separated by hydrologically closed... basins . Pine and Wah Wah valleys each have hardpan-playas in their lowest areas. State Highway 21 runs roughly northwest-southeast through both val...have been important for prehis- toric and historic use of the area. Pine Valley: Pine and Wah Wah valleys are closed alluvial basins . The central part

A landscape scale valley confinement algorithm: Delineating unconfined valley bottoms for geomorphic, aquatic, and riparian applications

Treesearch

David E. Nagel; John M. Buffington; Sharon L. Parkes; Seth Wenger; Jaime R. Goode

2014-01-01

Valley confinement is an important landscape characteristic linked to aquatic habitat, riparian diversity, and geomorphic processes. This report describes a GIS program called the Valley Confinement Algorithm (VCA), which identifies unconfined valleys in montane landscapes. The algorithm uses nationally available digital elevation models (DEMs) at 10-30 m resolution to...

Graphene Nanobubbles as Valley Filters and Beam Splitters

NASA Astrophysics Data System (ADS)

Settnes, Mikkel; Power, Stephen R.; Brandbyge, Mads; Jauho, Antti-Pekka

2016-12-01

The energy band structure of graphene has two inequivalent valleys at the K and K' points of the Brillouin zone. The possibility to manipulate this valley degree of freedom defines the field of valleytronics, the valley analogue of spintronics. A key requirement for valleytronic devices is the ability to break the valley degeneracy by filtering and spatially splitting valleys to generate valley polarized currents. Here, we suggest a way to obtain valley polarization using strain-induced inhomogeneous pseudomagnetic fields (PMFs) that act oppositely on the two valleys. Notably, the suggested method does not involve external magnetic fields, or magnetic materials, unlike previous proposals. In our proposal the strain is due to experimentally feasible nanobubbles, whose associated PMFs lead to different real space trajectories for K and K' electrons, thus allowing the two valleys to be addressed individually. In this way, graphene nanobubbles can be exploited in both valley filtering and valley splitting devices, and our simulations reveal that a number of different functionalities are possible depending on the deformation field.

Effect of a 20-day ski trek on fuel selection during prolonged exercise at low workload with ingestion of 13C-glucose.

PubMed

Péronnet, F; Abdelaoui, M; Lavoie, C; Marrao, C; Kerr, S; Massicotte, D; Giesbrecht, G

2009-05-01

Fuel selection was measured in five subjects (36.0 +/- 10.5 years old; 87.3 +/- 12.5 kg; mean +/- SD) during a 120-min tethered walking with ski poles (1.12 l O(2) min(-1)) with ingestion of (13)C-glucose (1.5 g kg(-1)), before and after a 20-day 415-km ski trek [physical activity level (PAL) approximately 3], using respiratory calorimetry, urea excretion, and (13)C/(12)C in expired CO(2) and in plasma glucose. Before the ski trek, protein oxidation contributed 9.7 +/- 1.6% to the energy yield (%En) while fat and carbohydrate (CHO) oxidation provided 73.5 +/- 5.5 and 16.7 +/- 6.5%En. Plasma glucose was the main source of CHO (52.9 +/- 9.5%En) with similar contributions from exogenous glucose (27.2 +/- 3.1%En), glucose from the liver (25.6 +/- 8.3%En) and muscle glycogen (20.9 +/- 4.0%En). Endogenous CHO contributed 46.6 +/- 3.9%En. Following the ski trek %En from protein, fat, CHO, exogenous glucose and endogenous CHO were not significantly modified (10.1 +/- 1.3, 15.8 +/- 6.7, 74.1 +/- 6.5, 28.7 +/- 3.0 and 45.5 +/- 7.5%En, respectively) but the %En from plasma glucose and glucose from the liver (41.1 +/- 3.6 and 12.4 +/- 4.0%En) were reduced, while that from muscle glycogen increased (33.0 +/- 4.5%En). These results show that in subjects in the fed state with glucose ingestion during exercise, CHO is the main substrate oxidized, with major contributions from both exogenous and endogenous CHO. Following a ~3-week period of prolonged low intensity exercise, the %En from protein, fat, CHO, exogenous glucose and endogenous CHO were not modified. However, the %En from glucose released from the liver was reduced (possibly due to an increased insulin sensitivity of the liver) while that from muscle glycogen was increased.

Occupational dermatoses from exposure to epoxy resin compounds in a ski factory.

PubMed

Jolanki, R; Tarvainen, K; Tatar, T; Estlander, T; Henriks-Eckerman, M L; Mustakallio, K K; Kanerva, L

1996-06-01

Of 22 workers in a ski factory, occupational allergic contact dermatitis was found in 8. 6 were sensitive to epoxy resin compounds, i.e., epoxy resins, hardeners or diluents, 1 to cobalt in glass-fiber reinforcements, and 1 to formaldehyde in a urea-formaldehyde glue and a lacquer. 4 workers had irritant contact dermatitis from epoxy resin compounds, lacquers, sanding dust, or glass-fiber dust. 3 had contact allergy from a new sensitizer, diethyleneglycol diglycidyl ether, in a reactive diluent. Immediate transfer of workers sensitized to epoxy resin from epoxy exposure prevents aggravation of their dermatitis and broadening of the sensitization to epoxy hardeners, diluents and other compounds.

BOUNDARY VALUE PROBLEM INVOLVING THE p-LAPLACIAN ON THE SIERPIŃSKI GASKET

NASA Astrophysics Data System (ADS)

Priyadarshi, Amit; Sahu, Abhilash

In this paper, we study the following boundary value problem involving the weak p-Laplacian. -Δpu=λa(x)|u|q-1u + b(x)|u|l-1uin 𝒮∖𝒮 0; u=0on 𝒮0, where 𝒮 is the Sierpiński gasket in ℝ2, 𝒮0 is its boundary, λ > 0, p > 1, 0 < q < p - 1 < l and a,b : 𝒮→ ℝ are bounded nonnegative functions. We will show the existence of at least two nontrivial weak solutions to the above problem for a certain range of λ using the analysis of fibering maps on suitable subsets.

The Long Valley Caldera GIS database

USGS Publications Warehouse

Battaglia, Maurizio; Williams, M.J.; Venezky, D.Y.; Hill, D.P.; Langbein, J.O.; Farrar, C.D.; Howle, J.F.; Sneed, M.; Segall, P.

2003-01-01

This database provides an overview of the studies being conducted by the Long Valley Observatory in eastern California from 1975 to 2001. The database includes geologic, monitoring, and topographic datasets related to Long Valley caldera. The CD-ROM contains a scan of the original geologic map of the Long Valley region by R. Bailey. Real-time data of the current activity of the caldera (including earthquakes, ground deformation and the release of volcanic gas), information about volcanic hazards and the USGS response plan are available online at the Long Valley observatory web page (http://lvo.wr.usgs.gov). If you have any comments or questions about this database, please contact the Scientist in Charge of the Long Valley observatory.

27 CFR 9.78 - Ohio River Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Ohio River Valley. 9.78... River Valley. (a) Name. The name of the viticultural area described in this section is “Ohio River Valley.” (b) Approved maps. The approved maps for determining the boundary of the Ohio River Valley...

Biomechanical characteristics and speed adaptation during kick double poling on roller skis in elite cross-country skiers.

PubMed

Göpfert, Caroline; Holmberg, Hans-Christer; Stöggl, Thomas; Müller, Erich; Lindinger, Stefan Josef

2013-06-01

Recent developments in cross-country ski racing should promote the use of kick double poling. This technique, however, has not been the focus in athletes' training and has barely been investigated. The aims of the present study were to develop a function-based phase definition and to analyse speed adaptation mechanisms for kick double poling in elite cross-country skiers. Joint kinematics and pole/plantar forces were recorded in 10 athletes while performing kick double poling at three submaximal roller skiing speeds. A speed increase was associated with increases in cycle length and rate, while absolute poling and leg push-off durations shortened. Despite maintained impulses of force, the peak and average pole/leg forces increased. During double poling and leg push-off, ranges of motion of elbow flexion and extension increased (p < 0.05) and were maintained for hip/knee flexion and extension. Cycle length increase was correlated to increases in average poling force (r = 0.71) and arm swing time (r = 0.88; both p < 0.05). The main speed adaptation was achieved by changes in double poling technique; however, leg push-off showed high variability among elite skiers, thus illustrating important aspects for technique training.

Valley dependent transport in graphene L junction

NASA Astrophysics Data System (ADS)

Chan, K. S.

2018-05-01

We studied the valley dependent transport in graphene L junctions connecting an armchair lead and a zigzag lead. The junction can be used in valleytronic devices and circuits. Electrons injected from the armchair lead into the junction is not valley polarized, but they can become valley polarized in the zigzag lead. There are Fermi energies, where the current in the zigzag lead is highly valley polarized and the junction is an efficient generator of valley polarized current. The features of the valley polarized current depend sensitively on the widths of the two leads, as well as the number of dimers in the armchair lead, because this number has a sensitive effect on the band structure of the armchair lead. When an external potential is applied to the junction, the energy range with high valley polarization is enlarged enhancing its function as a generator of highly valley polarized current. The scaling behavior found in other graphene devices is also found in L junctions, which means that the results presented here can be extended to junctions with larger dimensions after appropriate scaling of the energy.

Down in the Valley.

ERIC Educational Resources Information Center

Salter, Linda Graef

1999-01-01

Describes the partnerships formed by West Valley Mission Community College District (California) with its surrounding Silicon Valley business community in an effort to benefit workforce development. Asserts that community colleges are uniquely positioned to provide a lifelong education that will yield a skilled workforce to meet the needs of…

Hazardous Waste Cleanup: West Valley Demonstration Project USDOE in West Valley, New York

EPA Pesticide Factsheets

The U.S. Department of Energy's West Valley Demonstration Project is located at 10282 Rock Spring Road in West Valley, New York. This is a 167 acre, Department of Energy (DOE)-operated portion of a 3,300-acre site owned by the New York State Energy

Rift Valley Fever Virus

USDA-ARS?s Scientific Manuscript database

Rift Valley fever virus (RVFV) is a mosquito-transmitted virus or arbovirus that is endemic in sub-Saharan Africa. In the last decade, Rift Valley fever (RVF) outbreaks have resulted in loss of human and animal life, as well as had significant economic impact. The disease in livestock is primarily a...

Double-push skating versus V2 and V1 skating on uphill terrain in cross-country skiing.

PubMed

Stöggl, Thomas; Kampel, Wolfgang; Müller, Erich; Lindinger, Stefan

2010-01-01

The aims of the study were a) to compare the double-push skating technique with the V2 and the V1 skating techniques on an uphill terrain by a kinematic and kinetic analysis, b) to provide kinetic and kinematic data of the V1 technique at maximal skiing speeds, and c) to test the hypotheses that the double-push skating technique is faster compared with the V2 and the V1 skating techniques. Six elite skiers performed maximum speed sprints over a 60-m uphill section (7 degrees -10 degrees) using the double-push, the V2, and the V1 techniques. Pole and plantar forces and cycle characteristics were analyzed. The double-push skating technique was approximately 4.3% faster (P < 0.05) compared with the V2 skating technique and equally fast compared with the V1 skating technique. The double-push and the V2 techniques demonstrated longer cycle lengths, lower cycle rates (both P < 0.05), and equal poling frequencies and pole forces compared with the V1 technique. Cycle length, peak foot force, and knee extension ranges of motion and velocities were higher in the double-push technique compared with the V2 technique (all P values <0.05). Center of pressure was located more laterally in the double-push technique compared with the other two techniques (P < 0.05). All measured skiing speeds were drastically higher compared with former studies. The higher skiing speeds of the V1 and the double-push techniques compared with the V2 technique stress the mechanical advantage of those techniques on uphill terrain. Because of larger cycle lengths, lower cycle rate, longer recovery times, and equal poling frequency, the double-push technique might be seen as more economic on steep uphills compared with the V1 technique. From a tactical point of view compared with the V1 technique, the double-push technique needs less space due to less lateral displacement, and no technique transitions are necessary when entering and leaving an uphill section.

An evaluation of Skylab (EREP) remote sensing techniques applied to investigation of crustal structure. [Death Valley and Greenwater Valley (CA)

NASA Technical Reports Server (NTRS)

Bechtold, I. C. (Principal Investigator)

1974-01-01

The author has identified the following significant results. A study of Greenwater Valley indicates that the valley is bounded on the north and east by faults, on the south by a basement high, and on the west by the dip slope of the black mountains, movement of ground water from the valley is thus Movement of ground water from the valley is thus restricted, indicating the valley is a potential water reservoir.

Study of the slope of the linear relationship between retention and mobile phase composition (Snyder-Soczewiñski model) in normal phase liquid chromatography with bonded and charge-transfer phases.

PubMed

Wu, Di; Lucy, Charles A

2016-12-02

The Snyder model and the Soczewiñski model are compared on classic NPLC bonded phases using literature data, and on the charge transfer 2, 4-dinitroanilinopropyl (DNAP) column using experimentally collected data. Overall, the Snyder model slightly better predicts the n-slope than the Soczewiñski model. However, both models give comparable uncertainty in predicting n-slope for a given compound. The number of aromatic double bonds was the most suitable descriptor for estimating the relative n-slope of PAHs, as it correlated with behavior better than the number of aromatic rings and is simpler to calculate than the solute adsorption area. On the DNAP phase, a modified Soczewiñski model is suggested to allow for the significant contribution of the aromatic rings to the n-slope. For classic NPLC bonded phases and DNAP columns, the contribution of polar group to the n-slope parallels the adsorption energy of each polar group. Copyright © 2016 Elsevier B.V. All rights reserved.

Hydrology and water quality in two mountain basins of the northeastern US: Assessing baseline conditions and effects of ski area development

USGS Publications Warehouse

Wemple, B.; Shanley, J.; Denner, J.; Ross, D.; Mills, K.

2007-01-01

Mountain regions throughout the world face intense development pressures associated with recreational and tourism uses. Despite these pressures, much of the research on bio-geophysical impacts of humans in mountain regions has focused on the effects of natural resource extraction. This paper describes findings from the first 3 years of a study examining high elevation watershed processes in a region undergoing alpine resort development. Our study is designed as a paired-watershed experiment. The Ranch Brook watershed (9.6 km2) is a relatively pristine, forested watershed and serves as the undeveloped 'control' basin. West Branch (11.7 km2) encompasses an existing alpine ski resort, with approximately 17% of the basin occupied by ski trails and impervious surfaces, and an additional 7% slated for clearing and development. Here, we report results for water years 2001-2003 of streamflow and water quality dynamics for these watersheds. Precipitation increases significantly with elevation in the watersheds, and winter precipitation represents 36-46% of annual precipitation. Artificial snowmaking from water within West Branch watershed currently augments annual precipitation by only 3-4%. Water yield in the developed basin exceeded that in the control by 18-36%. Suspended sediment yield was more than two and a half times greater and fluxes of all major solutes were higher in the developed basin. Our study is the first to document the effects of existing ski area development on hydrology and water quality in the northeastern US and will serve as an important baseline for evaluating the effects of planned resort expansion activities in this area.

Influence of slope steepness, foot position and turn phase on plantar pressure distribution during giant slalom alpine ski racing.

PubMed

Falda-Buscaiot, Thomas; Hintzy, Frédérique; Rougier, Patrice; Lacouture, Patrick; Coulmy, Nicolas

2017-01-01

The purpose of this study was to investigate the evolution of ground reaction force during alpine skiing turns. Specifically, this study investigated how turn phases and slope steepness affected the whole foot normal GRF pattern while performing giant slalom turns in a race-like setting. Moreover, the outside foot was divided into different plantar regions to see whether those parameters affected the plantar pressure distribution. Eleven skiers performed one giant slalom course at race intensity. Runs were recorded synchronously using a video camera in the frontal plane and pressure insoles under both feet's plantar surface. Turns were divided according to kinematic criteria into four consecutive phases: initiation, steering1, steering2 and completion; both steering phases being separated by the gate passage. Component of the averaged Ground Reaction Force normal to the ski's surface([Formula: see text], /BW), and Pressure Time Integral relative to the entire foot surface (relPTI, %) parameters were calculated for each turn phases based on plantar pressure data. Results indicated that [Formula: see text] under the total foot surface differed significantly depending on the slope (higher in steep sections vs. flat sections), and the turn phase (higher during steering2 vs. three other phases), although such modifications were observable only on the outside foot. Moreover, [Formula: see text] under the outside foot was significantly greater than under the inside foot.RelPTI under different foot regions of the outside foot revealed a global shift from forefoot loading during initiation phase, toward heel loading during steering2 phase, but this was dependent on the slope studied. These results suggest a differentiated role played by each foot in alpine skiing turns: the outside foot has an active role in the turning process, while the inside foot may only play a role in stability.

27 CFR 9.154 - Chiles Valley.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Chiles Valley. (a) Name. The name of the viticultural area described in this section is “Chiles Valley... viticultural area are four 1:24,000 Scale U.S.G.S. topography maps. They are titled: (1) St. Helena, CA 1960 photorevised 1980; (2) Rutherford, CA 1951 photorevised 1968; (3) Chiles Valley, CA 1958 photorevised 1980; (4...

Meter-Scale Characteristics of Martian Channels and Valleys

USGS Publications Warehouse

Carr, M.H.; Malin, M.C.

2000-01-01

Mars Global Surveyor images, with resolutions as high as 1.5 m pixel, enable characterization of martian channels and valleys at resolutions one to two orders of magnitude better than was previously possible. A major surprise is the near-absence of valleys a few hundred meters wide and narrower. The almost complete absence of fine-scale valleys could be due to lack of precipitation, destruction of small valleys by erosion, or dominance of infiltration over surface runoff. V-shaped valleys with a central channel, such as Nanedi Vallis, provide compelling evidence for sustained or episodic flow of water across the surface. Larger valleys appear to have formed not by headward erosion as a consequence of groundwater sapping but by erosion from water sources upstream of the observed sections. The freshest appearing valleys have triangular cross sections, with talus from opposing walls meeting at the center of the valley. The relations suggest that the width of the valleys is controlled by the depth of incision and the angle of repose of the walls. The flat floors of less fresh-appearing valleys result primarily from later eolian fill. Several discontinuous valleys and lines of craters suggest massive subsurface solution or erosion. The climatic implications of the new images will remain obscure until the cause for the scarcity of fine-scale dissection is better understood. ?? 2000 Academic Press.

An Analysis of US Emergency Department Visits From Falls From Skiing, Snowboarding, Skateboarding, Roller-Skating, and Using Nonmotorized Scooters.

PubMed

Nathanson, Brian H; Ribeiro, Kara; Henneman, Philip L

2016-07-01

We analyzed the US incidence of emergency department (ED) visits and hospitalizations for falls from skiing, snowboarding, skateboarding, roller-skating, and nonmotorized scooters in 2011. The outcome was hospital admission from the ED. The primary analysis compared pediatric patients aged 1 to 17 years to adults aged 18 to 44 years. The analysis used ICD-9 E-codes E885.0 to E885.4 using discharge data from the Nationwide Emergency Department Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality. Approximately 214 000 ED visits met study criteria. Skiing injuries had the highest percentage of hospitalizations (3.30% in pediatric patients and 6.65% in adults 18-44 years old). Skateboard and snowboard injuries were more likely to require hospitalization than roller skating injuries in pediatric patients (odds ratio = 2.42; 95% CI = 2.14-2.75 and odds ratio = 1.83; 95% CI =1.55-2.15, respectively). In contrast, skateboard and snowboard injuries were less severe than roller-skating injuries in adults. © The Author(s) 2015.

(K, Na, Li)(Nb, Ta)O3:Mn lead-free single crystal with high piezoelectric properties

PubMed Central

Huo, Xiaoqing; Zhang, Rui; Zheng, Limei; Zhang, Shujun; Wang, Rui; Wang, Junjun; Sang, Shijing; Yang, Bin; Cao, Wenwu

2016-01-01

Lead-free single crystal, (K, Na, Li)(Nb, Ta)O3:Mn, was successfully grown using top-seeded solution growth method. Complete matrix of dielectric, piezoelectric and elastic constants for [001]C poled single crystal was determined. The piezoelectric coefficient d33 measured by the resonance method was 545 pC/N, which is almost three times that of its ceramic counterpart. The values measured by the Berlincourt meter ( d33∗=630pC/N) and strain-field curve ( d33∗∗=870pm/V) were even higher. The differences were assumed to relate with the different extrinsic contributions of domain wall vibration and domain wall translation during the measurements by different approaches, where the intrinsic contribution (on the order of 539 pm/V) was supposed to be the same. The crystal has ultrahigh electromechanical coupling factor (k33 ~ 95%) and high ultrasound velocity, which make it promising for high frequency medical transducer applications. PMID:27594704

Microscopic Identification of Prokaryotes in Modern and Ancient Halite, Saline Valley and Death Valley, California

NASA Astrophysics Data System (ADS)

Schubert, Brian A.; Lowenstein, Tim K.; Timofeeff, Michael N.

2009-06-01

Primary fluid inclusions in halite crystallized in Saline Valley, California, in 1980, 2004-2005, and 2007, contain rod- and coccoid-shaped microparticles the same size and morphology as archaea and bacteria living in modern brines. Primary fluid inclusions from a well-dated (0-100,000 years), 90 m long salt core from Badwater Basin, Death Valley, California, also contain microparticles, here interpreted as halophilic and halotolerant prokaryotes. Prokaryotes are distinguished from crystals on the basis of morphology, optical properties (birefringence), and uniformity of size. Electron micrographs of microparticles from filtered modern brine (Saline Valley), dissolved modern halite crystals (Saline Valley), and dissolved ancient halite crystals (Death Valley) support in situ microscopic observations that prokaryotes are present in fluid inclusions in ancient halite. In the Death Valley salt core, prokaryotes in fluid inclusions occur almost exclusively in halite precipitated in perennial saline lakes 10,000 to 35,000 years ago. This suggests that trapping and preservation of prokaryotes in fluid inclusions is influenced by the surface environment in which the halite originally precipitated. In all cases, prokaryotes in fluid inclusions in halite from the Death Valley salt core are miniaturized (<1 μm diameter cocci, <2.5 μm long, very rare rod shapes), which supports interpretations that the prokaryotes are indigenous to the halite and starvation survival may be the normal response of some prokaryotes to entrapment in fluid inclusions for millennia. These results reinforce the view that fluid inclusions in halite and possibly other evaporites are important repositories of microbial life and should be carefully examined in the search for ancient microorganisms on Earth, Mars, and elsewhere in the Solar System.

Valley Vortex States in Sonic Crystals

NASA Astrophysics Data System (ADS)

Lu, Jiuyang; Qiu, Chunyin; Ke, Manzhu; Liu, Zhengyou

2016-03-01

Valleytronics is quickly emerging as an exciting field in fundamental and applied research. In this Letter, we study the acoustic version of valley states in sonic crystals and reveal a vortex nature of such states. In addition to the selection rules established for exciting valley polarized states, a mimicked valley Hall effect of sound is proposed further. The extraordinary chirality of valley vortex states, detectable in experiments, may open a new possibility in sound manipulations. This is appealing to scalar acoustics that lacks a spin degree of freedom inherently. In addition, the valley selection enables a handy way to create vortex matter in acoustics, in which the vortex chirality can be controlled flexibly. Potential applications can be anticipated with the exotic interaction of acoustic vortices with matter, such as to trigger the rotation of the trapped microparticles without contact.

Topological Valley Transport in Two-dimensional Honeycomb Photonic Crystals.

PubMed

Yang, Yuting; Jiang, Hua; Hang, Zhi Hong

2018-01-25

Two-dimensional photonic crystals, in analogy to AB/BA stacking bilayer graphene in electronic system, are studied. Inequivalent valleys in the momentum space for photons can be manipulated by simply engineering diameters of cylinders in a honeycomb lattice. The inequivalent valleys in photonic crystal are selectively excited by a designed optical chiral source and bulk valley polarizations are visualized. Unidirectional valley interface states are proved to exist on a domain wall connecting two photonic crystals with different valley Chern numbers. With the similar optical vortex index, interface states can couple with bulk valley polarizations and thus valley filter and valley coupler can be designed. Our simple dielectric PC scheme can help to exploit the valley degree of freedom for future optical devices.

Optical tuning of electronic valleys (Conference Presentation)

NASA Astrophysics Data System (ADS)

Sie, Edbert J.; Gedik, Nuh

2017-02-01

Monolayer transition-metal dichalcogenides such as MoS2 and WS2 are prime examples of atomically thin semiconducting crystals that exhibit remarkable electronic and optical properties. They have a pair of valleys that can serve as a new electronic degree of freedom, and these valleys obey optical selection rules with circularly polarized light. Here, we discuss how ultrafast laser pulses can be used to tune their energy levels in a controllable valley-selective manner. The energy tunability is extremely large, comparable to what would be obtained using a hundred Tesla of magnetic field. We will also show that such valley tunability can be performed while we effectively manipulate the valley selection rules. Finally, we will explore the prospect of using this technique through photoemission spectroscopy to create a new phase of matter called a valley Floquet topological insulator.

Martian oceans, valleys and climate

USGS Publications Warehouse

Carr, M.H.

2000-01-01

The new Mars Global Surveyor altimetry shows that the heavily cratered southern hemisphere of Mars is 5 km higher that the sparely cratered plains of the northern hemisphere. Previous suggestions that oceans formerly occupied that northern plains as evidenced by shorelines are partly supported by the new data. A previously identified outer boundary has a wide range of elevations and is unlikely to be a shoreline but an inner contact with a narrow range of elevations is a more likely candidate. No shorelines are visible in the newly acquired, 2.5 metre/pixel imaging. Newly imaged valleys provide strong support for sustained or episodic flow of water across the Martian surface. A major surprise, however, is the near absence of valleys less than 100 m across. Martian valleys seemingly do not divide into ever smaller valleys as terrestrial valleys commonly do. This could be due to lack of precipitation or lack of surface runoff because of high infiltration rates. High erosion rates and supports warm climates and presence of large bodies of water during heavy bombardment. The climate history and fate of the water after heavy bombardment remain cotroversial.

Knickpoints and Hanging Valleys of Licus Vallis, Mars

NASA Astrophysics Data System (ADS)

Goudge, T. A.; Fassett, C.

2016-12-01

Licus Vallis is a 350 km long valley system located along the dichotomy boundary on Mars. The main trunk of the valley is incised 200-700 m into the surrounding terrain. The valley heads at an outlet breach of a shallow, 30 km diameter impact crater, and is also fed by a system of tributaries incised into the plateau surrounding Licus Vallis. Many of the tributary valleys, as well as the main stem of the valley fed by the paleolake outlet, have profiles that are not smoothly graded, but rather have distinct reaches with concave downward topography. These sections are either knickpoints or hanging valleys that develop in response to changes in the effective local base level, changes in climate conditions during incision of the valley, or lithologic boundaries in the substrate. Here we present remote sensing observations from images and topography to test these competing hypotheses and further characterize the evolution of this large valley system. Slope-watershed area relationships for the tributaries and main trunk valley are used to distinguish between knickpoints and hanging valleys. Analysis of orbital images does not reveal any distinct layer above which knickpoints develop, and the elevation of knickpoints show no systematic trends that might be expected of a regional lithologic unit(s). Our preliminary results suggest that the distance of knickpoint retreat is correlated with the position of the tributary valley and not the watershed area. Downstream valleys have retreated the most, suggesting they have had the most time to adjust to lowering of the local base level associated with incision of the main valley. These results are most consistent with a wave of incision sweeping up the valley system as it adjusts to a low base level in the northern plains. This conclusion is also consistent with observations of the incision depth of Licus Vallis, which increases approximately linearly downstream. Understanding this signature of base level control on the incision

Exercise economy in skiing and running

PubMed Central

Losnegard, Thomas; Schäfer, Daniela; Hallén, Jostein

2014-01-01

Substantial inter-individual variations in exercise economy exist even in highly trained endurance athletes. The variation is believed to be determined partly by intrinsic factors. Therefore, in the present study, we compared exercise economy in V2-skating, double poling, and uphill running. Ten highly trained male cross-country skiers (23 ± 3 years, 180 ± 6 cm, 75 ± 8 kg, VO2peak running: 76.3 ± 5.6 mL·kg−1·min−1) participated in the study. Exercise economy and VO2peak during treadmill running, ski skating (V2 technique) and double poling were compared based on correlation analysis. There was a very large correlation in exercise economy between V2-skating and double poling (r = 0.81) and large correlations between V2-skating and running (r = 0.53) and double poling and running (r = 0.58). There were trivial to moderate correlations between exercise economy and the intrinsic factors VO2peak (r = 0.00–0.23), cycle rate (r = 0.03–0.46), body mass (r = −0.09–0.46) and body height (r = 0.11–0.36). In conclusion, the inter-individual variation in exercise economy could be explained only moderately by differences in VO2peak, body mass and body height. Apparently other intrinsic factors contribute to the variation in exercise economy between highly trained subjects. PMID:24478718

An Inertial Sensor-Based Method for Estimating the Athlete's Relative Joint Center Positions and Center of Mass Kinematics in Alpine Ski Racing

PubMed Central

Fasel, Benedikt; Spörri, Jörg; Schütz, Pascal; Lorenzetti, Silvio; Aminian, Kamiar

2017-01-01

For the purpose of gaining a deeper understanding of the relationship between external training load and health in competitive alpine skiing, an accurate and precise estimation of the athlete's kinematics is an essential methodological prerequisite. This study proposes an inertial sensor-based method to estimate the athlete's relative joint center positions and center of mass (CoM) kinematics in alpine skiing. Eleven inertial sensors were fixed to the lower and upper limbs, trunk, and head. The relative positions of the ankle, knee, hip, shoulder, elbow, and wrist joint centers, as well as the athlete's CoM kinematics were validated against a marker-based optoelectronic motion capture system during indoor carpet skiing. For all joints centers analyzed, position accuracy (mean error) was below 110 mm and precision (error standard deviation) was below 30 mm. CoM position accuracy and precision were 25.7 and 6.7 mm, respectively. Both the accuracy and precision of the system to estimate the distance between the ankle of the outside leg and CoM (measure quantifying the skier's overall vertical motion) were found to be below 11 mm. Some poorer accuracy and precision values (below 77 mm) were observed for the athlete's fore-aft position (i.e., the projection of the outer ankle-CoM vector onto the line corresponding to the projection of ski's longitudinal axis on the snow surface). In addition, the system was found to be sensitive enough to distinguish between different types of turns (wide/narrow). Thus, the method proposed in this paper may also provide a useful, pervasive way to monitor and control adverse external loading patterns that occur during regular on-snow training. Moreover, as demonstrated earlier, such an approach might have a certain potential to quantify competition time, movement repetitions and/or the accelerations acting on the different segments of the human body. However, prior to getting feasible for applications in daily training, future studies

An Inertial Sensor-Based Method for Estimating the Athlete's Relative Joint Center Positions and Center of Mass Kinematics in Alpine Ski Racing.

PubMed

Fasel, Benedikt; Spörri, Jörg; Schütz, Pascal; Lorenzetti, Silvio; Aminian, Kamiar

2017-01-01

For the purpose of gaining a deeper understanding of the relationship between external training load and health in competitive alpine skiing, an accurate and precise estimation of the athlete's kinematics is an essential methodological prerequisite. This study proposes an inertial sensor-based method to estimate the athlete's relative joint center positions and center of mass (CoM) kinematics in alpine skiing. Eleven inertial sensors were fixed to the lower and upper limbs, trunk, and head. The relative positions of the ankle, knee, hip, shoulder, elbow, and wrist joint centers, as well as the athlete's CoM kinematics were validated against a marker-based optoelectronic motion capture system during indoor carpet skiing. For all joints centers analyzed, position accuracy (mean error) was below 110 mm and precision (error standard deviation) was below 30 mm. CoM position accuracy and precision were 25.7 and 6.7 mm, respectively. Both the accuracy and precision of the system to estimate the distance between the ankle of the outside leg and CoM (measure quantifying the skier's overall vertical motion) were found to be below 11 mm. Some poorer accuracy and precision values (below 77 mm) were observed for the athlete's fore-aft position (i.e., the projection of the outer ankle-CoM vector onto the line corresponding to the projection of ski's longitudinal axis on the snow surface). In addition, the system was found to be sensitive enough to distinguish between different types of turns (wide/narrow). Thus, the method proposed in this paper may also provide a useful, pervasive way to monitor and control adverse external loading patterns that occur during regular on-snow training. Moreover, as demonstrated earlier, such an approach might have a certain potential to quantify competition time, movement repetitions and/or the accelerations acting on the different segments of the human body. However, prior to getting feasible for applications in daily training, future studies

c-Ski, Smurf2, and Arkadia as regulators of TGF-beta signaling: new targets for managing myofibroblast function and cardiac fibrosis.

PubMed

Cunnington, Ryan H; Nazari, Mansoreh; Dixon, Ian M C

2009-10-01

Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production by cardiac myofibroblasts is essential. Transforming growth factor beta (TGF-beta) signaling is transduced through the canonical Smad pathway, and the involvement of this pathway in matrix synthesis and other processes requires precise control. Inhibition of Smad signaling may be achieved at the receptor level through the targeting of the TGF-beta type I receptors with an inhibitory Smad7/Smurf2 complex, or at the transcriptional level through c-Ski/receptor-Smad/co-mediator Smad4 interactions. Conversely, Arkadia protein intensifies TGF-beta-induced effects by marking c-Ski and inhibitory Smad7 for destruction. The study of these TGF-beta mediators is essential for future treatment of fibrotic disease, and this review highlights recent relevant findings that may impact our understanding of cardiac fibrosis.

Magnetic control of valley pseudospin in monolayer WSe 2

DOE PAGES

Aivazian, G.; Gong, Zhirui; Jones, Aaron M.; ...

2015-01-26

Local energy extrema of the bands in momentum space, or valleys, can endow electrons in solids with pseudo-spin in addition to real spin 1-5. In transition metal dichalcogenides this valley pseudo-spin, like real spin, is associated with a magnetic moment1,6 which underlies the valley-dependent circular dichroism 6 that allows optical generation of valley polarization 7-9, intervalley quantum coherence 10, and the valley Hall effect 11. However, magnetic manipulation of valley pseudospin via this magnetic moment 12-13, analogous to what is possible with real spin, has not been shown before. Here we report observation of the valley Zeeman splitting and magneticmore » tuning of polarization and coherence of the excitonic valley pseudospin, by performing polarization-resolved magneto-photoluminescence on monolayer WSe 2. Our measurements reveal both the atomic orbital and lattice contributions to the valley orbital magnetic moment; demonstrate the deviation of the band edges in the valleys from an exact massive Dirac fermion model; and reveal a striking difference between the magnetic responses of neutral and charged valley excitons which is explained by renormalization of the excitonic spectrum due to strong exchange interactions.« less

Spin and valley filter across line defect in silicene

NASA Astrophysics Data System (ADS)

Wang, Sake; Ren, Chongdan; Li, Yunfang; Tian, Hongyu; Lu, Weitao; Sun, Minglei

2018-05-01

We propose a new scheme to achieve an effective spin/valley filter in silicene with extended line defect on the basis of spin–valley coupling due to the intrinsic spin-orbit coupling (SOC). The transmission coefficient of the spin/valley states is seriously affected by the SOC. When a perpendicular magnetic field is applied on one side of the line defect, one valley state will experience backscattering, but the other valley will not; this leads to high valley polarization in all transmission directions. Moreover, the spin/valley polarization can be enhanced to 96% with the aid of a perpendicular electric field.

Epidemiology of Snow Skiing- Versus Snowboarding-Related Concussions Presenting to the Emergency Department in the United States from 2010 to 2014.

PubMed

Gil, Joseph A; DeFroda, Steven F; Kriz, Peter; Owens, Brett D

2017-09-01

To examine the trend of concussions in skiers and snowboarders from 2010 to 2014; and to quantify and compare the incidence of concussions injuries in skiers and snowboarders who presented to emergency departments in the United States in 2014. Cross-sectional study of concussions in skiers and snowboarders who were evaluated in emergency departments in the United States. Incidence of concussions. The trend of the annual incidence of concussions for skiers and snowboarders remained stable from 2010 to 2014. An estimated total of 5388 skiing-related concussions and 5558 snowboarding-related concussions presented to emergency departments in the United States between January 1st, 2014, and December 31st, 2014. This represented an incidence of 16.9 concussions per 1 000 000 person-years for skiers and 17.4 concussions per 1 000 000 person-years for snowboarders. The incidence of concussions in the pediatric and young adult population of skiers was significantly higher than the incidence in the adult population. Similarly, the incidence of concussions in the pediatric and young adult population of snowboarders was significantly higher than the incidence in the adult population. The incidence of concussions was significantly higher in males compared with females in both skiing and snowboarding. The incidence of concussions from 2010 to 2014 plateaued in both skiers and snowboarders. Pediatric and young adult skiers and snowboarders had significantly higher incidences of concussion than the adult population. In contrast to the higher incidence of concussions in females in several sports including ice hockey, soccer, and basketball, the incidence of concussions was higher in males compared with females in both skiing and snowboarding.

27 CFR 9.36 - McDowell Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

....” (b) Approved maps. The appropriate map for determining the boundaries of the McDowell Valley... and the ridge line (highest elevation line) between the McDowell Creek Valley and the Dooley Creek Valley. (3) Then southeasterly along the ridge line (highest elevation line) to the intersection of the...

27 CFR 9.36 - McDowell Valley.

Code of Federal Regulations, 2011 CFR

2011-04-01

....” (b) Approved maps. The appropriate map for determining the boundaries of the McDowell Valley... and the ridge line (highest elevation line) between the McDowell Creek Valley and the Dooley Creek Valley. (3) Then southeasterly along the ridge line (highest elevation line) to the intersection of the...

The Impact of Coenzyme Q[subscript10] Supplement on the Indicators of Muscle Damage in Young Male Skiing Athletes

ERIC Educational Resources Information Center

Demirci, Nevzat

2015-01-01

This study was conducted in order to know the impact of coenzyme Q[subscript 10] (CoQ[subscript 10]) supplement on the muscle damage and total oxidant (TOS) enzyme levels of young skiing athletes during exercise. 15 male athletes were used for two weeks in the study. The athletes were divided into three groups: the control group and two subject…

Methods for acquiring data on terrain geomorphology, course geometry and kinematics of competitors' runs in alpine skiing: a historical review.

PubMed

Erdmann, Włodzimierz S; Giovanis, Vassilis; Aschenbrenner, Piotr; Kiriakis, Vaios; Suchanowski, Andrzej

2017-01-01

This paper aims at the description and comparison of methods of topographic analysis of racing courses at all disciplines of alpine skiing sports for the purposes of obtaining: terrain geomorphology (snowless and with snow), course geometry, and competitors' runs. The review presents specific methods and instruments according to the order of their historical appearance as follows: (1) azimuth method with the use of a compass, tape and goniometer instruments; (2) optical method with geodetic theodolite, laser and photocells; (3) triangulation method with the aid of a tape and goniometer; (4) image method with the use of video cameras; (5) differential global positioning system and carrier phase global positioning system methods. Described methods were used at homologation procedure, at training sessions, during competitions of local level and during International Ski Federation World Championships or World Cups. Some methods were used together. In order to provide detailed data on course setting and skiers' running it is recommended to analyse course geometry and kinematics data of competitors' running for all important competitions.

Valley Near Nilus Chaos

NASA Technical Reports Server (NTRS)

2003-01-01

MGS MOC Release No. MOC2-504, 5 October 2003

This August 2003 Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a valley near Nilus Chaos, around 25.2oN, 80.3oW. The scene has a uniform albedo, indicating that all of the landforms are probably mantled by fine, bright dust. Dark streaks on the valley walls indicate places where recent dust avalanches have occurred. The ripple-like dune features on the valley floor were formed by wind, but today they are inactive and covered with dust. A few craters, created by impacting debris, have formed on the dunes, again attesting to their inactivity in the modern martian environment. The image covers an area 3 km (1.9 mi) wide; it is illuminated by sunlight from the lower left.

27 CFR 9.194 - San Antonio Valley.

Code of Federal Regulations, 2011 CFR

2011-04-01

... significance. (b) Approved Maps. The appropriate maps for determining the boundary of the San Antonio Valley...) Hames Valley, California, 1949, photorevised 1978; (2) Tierra Redonda Mountain, California, 1949... southeast corner of section 14, T23S, R9E, on the Hames Valley map; (2) From the beginning point, proceed...

Morning Transition Tracer Experiments in a Deep Narrow Valley.

NASA Astrophysics Data System (ADS)

Whiteman, C. David

1989-07-01

Three sulfur hexafluoride atmospheric tracer experiments were conducted during the post-sunrise temperature inversion breakup period in the deep, narrow Brush Creek Valley of Colorado. Experiments were conducted under clear, undisturbed weather conditions.A continuous elevated tracer plume was produced along the axis of the valley before sunrise and the behavior of the plume during the inversion breakup period was detected down-valley from the release point using an array of radio-controlled sequential bag samplers, a vertical SF6 profiling system carried on a tethered balloon, two portable gas chromatographs operated on a sidewall of the valley, and a continuous real-time SF6 monitor operated from a research aircraft. Supporting meteorological data came primarily from tethered balloon profilers. The nocturnal elevated plume was carried and diffused in down-valley flows. After sunrise, convective boundary layers grew upward from the sunlit valley surfaces, fumigating the elevated plume onto the valley floor and sidewalls. Upslope flow developed in the growing convective boundary layers, carrying fumigated SF6 up the sidewalls and causing a compensating subsidence over the valley center. High post-sunrise SF6 concentrations were experienced on the northeast-facing sidewall of the northwest-southeast oriented valley as a result of cross-valley flow, which developed due to differential solar heating of the sidewalls. Reversal of the down-valley wind system brought air with lower SF6 concentrations into the lower valley.

The Central Valley Hydrologic Model

NASA Astrophysics Data System (ADS)

Faunt, C.; Belitz, K.; Hanson, R. T.

2009-12-01

Historically, California’s Central Valley has been one of the most productive agricultural regions in the world. The Central Valley also is rapidly becoming an important area for California’s expanding urban population. In response to this competition for water, a number of water-related issues have gained prominence: conjunctive use, artificial recharge, hydrologic implications of land-use change, subsidence, and effects of climate variability. To provide information to stakeholders addressing these issues, the USGS made a detailed assessment of the Central Valley aquifer system that includes the present status of water resources and how these resources have changed over time. The principal product of this assessment is a tool, referred to as the Central Valley Hydrologic Model (CVHM), that simulates surface-water flows, groundwater flows, and land subsidence in response to stresses from human uses and from climate variability throughout the entire Central Valley. The CVHM utilizes MODFLOW combined with a new tool called “Farm Process” to simulate groundwater and surface-water flow, irrigated agriculture, land subsidence, and other key processes in the Central Valley on a monthly basis. This model was discretized horizontally into 20,000 1-mi2 cells and vertically into 10 layers ranging in thickness from 50 feet at the land surface to 750 feet at depth. A texture model constructed by using data from more than 8,500 drillers’ logs was used to estimate hydraulic properties. Unmetered pumpage and surface-water deliveries for 21 water-balance regions were simulated with the Farm Process. Model results indicate that human activities, predominately surface-water deliveries and groundwater pumping for irrigated agriculture, have dramatically influenced the hydrology of the Central Valley. These human activities have increased flow though the aquifer system by about a factor of six compared to pre-development conditions. The simulated hydrology reflects spatial

NV PFA - Steptoe Valley

DOE Data Explorer

Jim Faulds

2015-10-29

All datasets and products specific to the Steptoe Valley model area. Includes a packed ArcMap project (.mpk), individually zipped shapefiles, and a file geodatabase for the northern Steptoe Valley area; a GeoSoft Oasis montaj project containing GM-SYS 2D gravity profiles along the trace of our seismic reflection lines; a 3D model in EarthVision; spreadsheet of links to published maps; and spreadsheets of well data.

27 CFR 9.27 - Lime Kiln Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Lime Kiln Valley. 9.27... OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.27 Lime Kiln Valley. (a) Name. The name of the viticultural area described in this section is “Lime Kiln Valley...

‘Valley Pearl’ table grape

USDA-ARS?s Scientific Manuscript database

‘Valley Pearl’ is an early to mid-season, white seedless table grape (Vitis vinifera L.) suitable for commercial table grape production where V. vinifera can be grown. Significant characteristics of ‘Valley Pearl’ are its high and consistent fruit production on spur pruned vines and large round berr...

Extraction of Martian valley networks from digital topography

NASA Technical Reports Server (NTRS)

Stepinski, T. F.; Collier, M. L.

2004-01-01

We have developed a novel method for delineating valley networks on Mars. The valleys are inferred from digital topography by an autonomous computer algorithm as drainage networks, instead of being manually mapped from images. Individual drainage basins are precisely defined and reconstructed to restore flow continuity disrupted by craters. Drainage networks are extracted from their underlying basins using the contributing area threshold method. We demonstrate that such drainage networks coincide with mapped valley networks verifying that valley networks are indeed drainage systems. Our procedure is capable of delineating and analyzing valley networks with unparalleled speed and consistency. We have applied this method to 28 Noachian locations on Mars exhibiting prominent valley networks. All extracted networks have a planar morphology similar to that of terrestrial river networks. They are characterized by a drainage density of approx.0.1/km, low in comparison to the drainage density of terrestrial river networks. Slopes of "streams" in Martian valley networks decrease downstream at a slower rate than slopes of streams in terrestrial river networks. This analysis, based on a sizable data set of valley networks, reveals that although valley networks have some features pointing to their origin by precipitation-fed runoff erosion, their quantitative characteristics suggest that precipitation intensity and/or longevity of past pluvial climate were inadequate to develop mature drainage basins on Mars.

Dynamics of Katabatic Winds in Colorado' Brush Creek Valley.

NASA Astrophysics Data System (ADS)

Vergeiner, I.; Dreiseitl, E.; Whiteman, C. David

1987-01-01

A method is proposed to evaluate the coupled mass, momentum and thermal energy budget equations for a deep valley under two-dimensional, steady-state flow conditions. The method requires the temperature, down- valley wind and valley width fields to be approximated by simple analytical functions. The vertical velocity field is calculated using the mass continuity equation. Advection terms in the momentum and energy equations are then calculated using finite differences computed on a vertical two-dimensional grid that runs down the valley's axis. The pressure gradient term in the momentum equation is calculated from the temperature field by means of the hydrostatic equation. The friction term is then calculated as a residual in the xmomentum equation, and the diabatic cooling term is calculated as a residual in the thermal energy budget equation.The method is applied to data from an 8-km-long segment of Colorado's; Brush Creek Valley on the night of 30-31 July 1982. Pressure decreased with distance down the peak on horizontal surfaces, with peak horizontal pressure gradients of 0.04 hPa km1. The valley mass budget indicated that subsidence was required in the valley to support calculated mean along-valley mass flux divergence. Peak subsidence rates on the order of 0.10 m s1 were calculated. Subsiding motions in the valley produced negative vertical down-valley momentum fluxes in the upper valley atmosphere, but produced positive down-valley momentum fluxes below the level of the jet. Friction, calculated as a residual in the x momentum equation, was negative, as expected on physical grounds. and attained reasonable quantitative values.The strong subsidence field in the stable valley atmosphere produced subsidence warming that was only partly counteracted by down-valley cold air advection. Strong diabatic cooling was therefore required in order to account for the weak net cooling of the valley atmosphere during the nighttime period when tethered balloon observations

Late winter home range and habitat use of the Virginia northern flying squirrel (Glaucomys sabrinus fuscus)

Treesearch

W. Mark Ford; Kely N. Mertz; Jennifer M. Menzel; Kenneth K. Sturm

2007-01-01

We radio-tracked two male and one female Virginia northern flying squirrels (Glaucomys sabrinus fuscus) in the Allegheny Mountains of West Virginia at Snowshoe Mountain Resort, in winter 2003 and Canaan Valley National Wildlife Refuge in winter 2004, respectively, to document winter home range and habitat use in or near ski areas. Male home range...

Fretted Terrain Valley in Coloe Fossae Region

NASA Technical Reports Server (NTRS)

2006-01-01

[figure removed for brevity, see original site] Figure 1 Click on image for larger version

The image in figure 1 shows lineated valley fill in one of a series of enclosed, intersecting troughs known as Coloe (Choloe) Fossae. Lineated valley fill consists of rows of material in valley centers that are parallel to the valley walls. It is probably made of ice-rich material and boulders that are left behind when the ice-rich material sublimates. Very distinct rows can be seen near the south (bottom) wall of the valley. Lineated valley fill is thought to result from mass wasting (downslope movement) of ice-rich material from valley walls towards their centers. It is commonly found in valleys near the crustal dichotomy that separates the two hemispheres of Mars. The valley shown here joins four other valleys with lineated fill near the top left corner of this image. Their juncture is a topographic low, suggesting that the lineated valley fill from the different valleys may be flowing or creeping towards the low area (movement towards the upper left of the image). The valley walls appear smooth at first glance but are seen to be speckled with small craters several meters in diameter at HiRISE resolution (see contrast-enhanced subimage). This indicates that at least some of the wall material has been stable to mass wasting for some period of time. Also seen on the valley wall are elongated features shaped like teardrops. These are most likely slightly older craters that have been degraded due to potentially recent downhill creep. It is unknown whether the valley walls are shedding material today. The subimage is approximately 140 x 400 m (450 x 1280 ft).

Image PSP_001372_2160 was taken by the High Resolution Imaging Science Experiment (HiRISE) camera onboard the Mars Reconnaissance Orbiter spacecraft on November 11, 2006. The complete image is centered at 35.5 degrees latitude, 56.8 degrees East longitude. The range to the target site was 290.3 km (181

Victor Valley College Agreement between the Victor Valley Community College District and the Victor Valley College California Teachers Association Chapter 1170. July 1989 - June 1992.

ERIC Educational Resources Information Center

Victor Valley Community Coll. District, Victorville, CA.

The collective bargaining agreement between the Victor Valley College Board of Trustees and the Victor Valley College California Teachers Association/National Education Association is presented. This contract, covering the period from July 1989 through June 1992, deals with the following topics: bargaining agent recognition; district and…

Valley spin polarization of Tl/Si(111)

NASA Astrophysics Data System (ADS)

Stolwijk, Sebastian D.; Schmidt, Anke B.; Sakamoto, Kazuyuki; Krüger, Peter; Donath, Markus

2017-11-01

The metal/semiconductor hybrid system Tl/Si(111)-(1 ×1 ) exhibits a unique Tl-derived surface state with remarkable properties. It lies within the silicon band gap and forms spin-momentum-locked valleys close to the Fermi energy at the K ¯ and K¯' points. These valleys are completely spin polarized with opposite spin orientation at K ¯ and K¯' and show a giant spin splitting of more than 0.5 eV. We present a detailed preparation study of the surface system and demonstrate that the electronic valleys are extremely robust, surviving exposure to 100 L hydrogen and 500 L oxygen. We investigate the influence of additional Tl atoms on the spin-polarized valleys. By combining photoemission and inverse photoemission, we prove the existence of fully spin-polarized valleys crossing the Fermi level. Moreover, these metallic valleys carry opposite Berry curvature at K ¯ and K¯', very similar to WSe2, promising a large spin Hall effect. Thus, Tl/Si(111)-(1 ×1 ) possesses all necessary key properties for spintronic applications.

Electrical valley filtering in transition metal dichalcogenides

NASA Astrophysics Data System (ADS)

Hsieh, Tzu-Chi; Chou, Mei-Yin; Wu, Yu-Shu

2018-03-01

This work investigates the feasibility of electrical valley filtering for holes in transition metal dichalcogenides. We look specifically into the scheme that utilizes a potential barrier to produce valley-dependent tunneling rates, and perform the study with both a k .p -based analytic method and a recursive Green's function-based numerical method. The study yields the transmission coefficient as a function of incident energy and transverse wave vector, for holes going through lateral quantum barriers oriented in either armchair or zigzag directions, in both homogeneous and heterogeneous systems. The main findings are the following: (1) The tunneling current valley polarization increases with increasing barrier width or height; (2) both the valley-orbit interaction and band structure warping contribute to valley-dependent tunneling, with the former contribution being manifest in structures with asymmetric potential barriers, and the latter being orientation dependent and reaching maximum for transmission in the armchair direction; and (3) for transmission ˜0.1 , a tunneling current valley polarization of the order of 10 % can be achieved.

Observation of valley-dependent beams in photonic graphene.

PubMed

Deng, Fusheng; Sun, Yong; Wang, Xiao; Xue, Rui; Li, Yuan; Jiang, Haitao; Shi, Yunlong; Chang, Kai; Chen, Hong

2014-09-22

Valley-dependent propagation of light in an artificial photonic hexagonal lattice, akin to electrons in graphene, is investigated in microwave regime. Both numerical and experimental results show that the valley degeneracy in the photonic graphene is broken when the frequency is away from the Dirac point. The peculiar anisotropic wave transport property due to distinct valleys is analyzed using the equifrequency contours. More interestingly, the valley-dependent self-collimation and beam splitting phenomena are experimentally demonstrated with the armchair and zigzag interfaces, respectively. Our results confirm that there are two inequivalent Dirac points that lead to two distinct valleys in photonic graphene, which could be used to control the flow of light and might be used to carry information in valley polarized beam splitter, collimator or guiding device.

27 CFR 9.58 - Carmel Valley.

Code of Federal Regulations, 2011 CFR

2011-04-01

....” (b) Approved maps. The approved maps for determining the boundary of the Carmel Valley viticultural... Ridge, Calif., dated 1956; and (5) Rana Creek, Calif., dated 1956. (c) Boundary. The Carmel Valley...

27 CFR 9.58 - Carmel Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

....” (b) Approved maps. The approved maps for determining the boundary of the Carmel Valley viticultural... Ridge, Calif., dated 1956; and (5) Rana Creek, Calif., dated 1956. (c) Boundary. The Carmel Valley...

Water resources of Parowan Valley, Iron County, Utah

USGS Publications Warehouse

Marston, Thomas M.

2017-08-29

Parowan Valley, in Iron County, Utah, covers about 160 square miles west of the Red Cliffs and includes the towns of Parowan, Paragonah, and Summit. The valley is a structural depression formed by northwest-trending faults and is, essentially, a closed surface-water basin although a small part of the valley at the southwestern end drains into the adjacent Cedar Valley. Groundwater occurs in and has been developed mainly from the unconsolidated basin-fill aquifer. Long-term downward trends in groundwater levels have been documented by the U.S. Geological Survey (USGS) since the mid-1950s. The water resources of Parowan Valley were assessed during 2012 to 2014 with an emphasis on refining the understanding of the groundwater and surface-water systems and updating the groundwater budget.Surface-water discharge of five perennial mountain streams that enter Parowan Valley was measured from 2013 to 2014. The total annual surface-water discharge of the five streams during 2013 to 2014 was about 18,000 acre-feet (acre-ft) compared to the average annual streamflow of about 22,000 acre-ft from USGS streamgages operated on the three largest of these streams from the 1940s to the 1980s. The largest stream, Parowan Creek, contributes more than 50 percent of the annual surface-water discharge to the valley, with smaller amounts contributed by Red, Summit, Little, and Cottonwood Creeks.Average annual recharge to the Parowan Valley groundwater system was estimated to be about 25,000 acre-ft from 1994 to 2013. Nearly all recharge occurs as direct infiltration of snowmelt and rainfall on the Markagunt Plateau east of the valley. Smaller amounts of recharge occur as infiltration of streamflow and unconsumed irrigation water near the east side of the valley on alluvial fans associated with mountain streams at the foot of the Red Cliffs. Subsurface flow from the mountain block to the east of the valley is a significant source of groundwater recharge to the basin-fill aquifer

Optical manipulation of valley pseduospin in 2D semiconductors

NASA Astrophysics Data System (ADS)

Ye, Ziliang

Valley polarization associated with the occupancy in the energy degenerate but quantum mechanically distinct valleys in the momentum space closely resembles spin polarization and has been proposed as a pseudospin carrier for future quantum information technologies. Monolayers of transition metal dichalcogenide (TMDC) crystals, with broken inversion symmetry and large spin-orbital coupling, support robust valley polarization and therefore provide an important platform for studying valley-dependent physics. Besides optical excitation and photoluminescence detection, valley polarization has been electrically measured through the valley Hall effect and created through spin injection from ferromagnetic semiconductor contacts. Moreover, the energy degeneracy of the valley degree of freedom has been lifted by the optical Stark effect. Recently, we have demonstrated optical manipulation of valley coherence, i.e., of the valley pseudospin, by the optical Stark effect in monolayer WSe2. Using below-bandgap circularly polarized light, we rotated the valley pseudospin on the femtosecond time scale. Both the direction and speed of the rotation can be optically controlled by tuning the dynamic phase of excitons in opposite valleys. The pseudospin rotation was identified by changes in the polarization of the photoluminescence. In addition, by varying the time delay between the excitation and control pulses, we directly probed the lifetime of the intervalley coherence. Similar rotation levels have also been observed in static magneto-optic experiments. Our work presents an important step towards the full control of the valley degree of freedom in 2D semiconductors. The work was done in collaboration with Dr. Dezheng Sun and Prof. Tony F. Heinz.

Origin of the Valley Networks On Mars: A Hydrological Perspective

NASA Technical Reports Server (NTRS)

Gulick, Virginia C.

2000-01-01

The geomorphology of the Martian valley networks is examined from a hydrological perspective for their compatibility with an origin by rainfall, globally higher heat flow, and localized hydrothermal systems. Comparison of morphology and spatial distribution of valleys on geologic surfaces with terrestrial fluvial valleys suggests that most Martian valleys are probably not indicative of a rainfall origin, nor are they indicative of formation by an early global uniformly higher heat flow. In general, valleys are not uniformly distributed within geologic surface units as are terrestrial fluvial valleys. Valleys tend to form either as isolated systems or in clusters on a geologic surface unit leaving large expanses of the unit virtually untouched by erosion. With the exception of fluvial valleys on some volcanoes, most Martian valleys exhibit a sapping morphology and do not appear to have formed along with those that exhibit a runoff morphology. In contrast, terrestrial sapping valleys form from and along with runoff valleys. The isolated or clustered distribution of valleys suggests localized water sources were important in drainage development. Persistent ground-water outflow driven by localized, but vigorous hydrothermal circulation associated with magmatism, volcanism, impacts, or tectonism is, however, consistent with valley morphology and distribution. Snowfall from sublimating ice-covered lakes or seas may have provided an atmospheric water source for the formation of some valleys in regions where the surface is easily eroded and where localized geothermal/hydrothermal activity is sufficient to melt accumulated snowpacks.

EPA Region 1 - Valley Depth in Meters

EPA Pesticide Factsheets

Raster of the Depth in meters of EPA-delimited Valleys in Region 1.Valleys (areas that are lower than their neighbors) were extracted from a Digital Elevation Model (USGS, 30m) by finding the local average elevation, subtracting the actual elevation from the average, and selecting areas where the actual elevation was below the average. The landscape was sampled at seven scales (circles of 1, 2, 4, 7, 11, 16, and 22 km radius) to take into account the diversity of valley shapes and sizes. Areas selected in at least four scales were designated as valleys.

Preliminary hydrogeologic assessment near the boundary of the Antelope Valley and El Mirage Valley groundwater basins, California

USGS Publications Warehouse

Stamos, Christina L.; Christensen, Allen H.; Langenheim, Victoria

2017-07-19

The increasing demands on groundwater for water supply in desert areas in California and the western United States have resulted in the need to better understand groundwater sources, availability, and sustainability. This is true for a 650-square-mile area that encompasses the Antelope Valley, El Mirage Valley, and Upper Mojave River Valley groundwater basins, about 50 miles northeast of Los Angeles, California, in the western part of the Mojave Desert. These basins have been adjudicated to ensure that groundwater rights are allocated according to legal judgments. In an effort to assess if the boundary between the Antelope Valley and El Mirage Valley groundwater basins could be better defined, the U.S. Geological Survey began a cooperative study in 2014 with the Mojave Water Agency to better understand the hydrogeology in the area and investigate potential controls on groundwater flow and availability, including basement topography.Recharge is sporadic and primarily from small ephemeral washes and streams that originate in the San Gabriel Mountains to the south; estimates range from about 400 to 1,940 acre-feet per year. Lateral underflow from adjacent basins has been considered minor in previous studies; underflow from the Antelope Valley to the El Mirage Valley groundwater basin has been estimated to be between 100 and 1,900 acre-feet per year. Groundwater discharge is primarily from pumping, mostly by municipal supply wells. Between October 2013 and September 2014, the municipal pumpage in the Antelope Valley and El Mirage Valley groundwater basins was reported to be about 800 and 2,080 acre-feet, respectively.This study was motivated by the results from a previously completed regional gravity study, which suggested a northeast-trending subsurface basement ridge and saddle approximately 3.5 miles west of the boundary between the Antelope Valley and El Mirage Valley groundwater basins that might influence groundwater flow. To better define potential basement

Virtual reality balance training for elderly: Similar skiing games elicit different challenges in balance training.

PubMed

de Vries, Aijse W; Faber, Gert; Jonkers, Ilse; Van Dieen, Jaap H; Verschueren, Sabine M P

2018-01-01

Virtual Reality (VR) balance training may have advantages over regular exercise training in older adults. However, results so far are conflicting potentially due to the lack of challenge imposed by the movements in those games. Therefore, the aim of this study was to assess to which extent two similar skiing games challenge balance, as reflected in center of mass (COM) movements relative to their Functional Limits of Stability (FLOS). Thirty young and elderly participants performed two skiing games, one on the Wii Balance board (Wiiski), which uses a force plate, and one with the Kinect sensor (Kinski), which performs motion tracking. During gameplay, kinematics were captured using seven opto-electronical cameras. FLOS were obtained for eight directions. The influence of games and trials on COM displacement in each of the eight directions, and maximal COM speed, were tested with Generalized Estimated Equations. In all directions with anterior and medio-lateral, but not with a posterior component, subjects showed significantly larger maximal %FLOS displacements during the Kinski game than during the Wiiski game. Furthermore, maximal COM displacement, and COM speed in Kinski remained similar or increased over trials, whereas for Wiiski it decreased. Our results show the importance of assessing the movement challenge in games used for balance training. Similar games impose different challenges, with the control sensors and their gain settings playing an important role. Furthermore, adaptations led to a decrease in challenge in Wiiski, which might limit the effectiveness of the game as a balance-training tool. Copyright © 2017 Elsevier B.V. All rights reserved.

Impact of Communication Barriers on Urban Development of Nowogród Bobrzański

NASA Astrophysics Data System (ADS)

Laskowski, Janusz; Juszczyk, Artur

2016-09-01

Network communication links is an indispensable element of development shaping. Any change in the way of using area should be preceded by an analysis of future impact taking into account the transport capacity. The development of buildings without adequate communication links leads to restrictions on object access, consequently it may lead to dangerous mishaps. Avoiding this type of situation is possible by carrying out sustainable development. The paper describes the relationship between the road system and urban layout on the example of Nowogród Bobrzański part of the city. One presented existing changes in the transportation system and its impact on local residents.

Control of Exciton Valley Coherence in Transition Metal Dichalcogenide Monolayers

NASA Astrophysics Data System (ADS)

Wang, Gang

Current research on Transition Metal Dichalcogenide (TMD) Monolayers is stimulated by their strong light-matter interaction and the possibility to use the valley index in addition to spin as an information carrier. The direct gap interband transitions in TMD monolayers are governed by chiral optical selection rules. Determined by laser helicity, optical transitions in either the K+ or K- valley in momentum space are induced. Very recently the optical generation of valley polarization and valley coherence (coherent superposition of valley states) have been reported. In this work we go a step further by discussing the coherent manipulation of valley states. Linearly polarized laser excitation prepares a coherent superposition of valley states. We demonstrate the control of the exciton valley coherence in monolayer WSe2 by tuning the applied magnetic field perpendicular to the monolayer plane. The induced valley Zeeman splitting between K+ and K- results in a change of the oscillation frequency of the superposition of the valley states, which corresponds to a rotation of the exciton valley pseudo-spin. We show rotation of this coherent superposition of valley states by angles as large as 30 degrees in applied fields up to 9T and discuss valley coherence in other TMD monolayer materials. This exciton valley coherence control on ps time scale could be an important step towards complete control of qubits based on the valley degree of freedom. In collaboration with X. Marie, T. Amand, C. Robert, F. Cadiz, P. Renucci, B. Urbaszek (Université de Toulouse, INSA-CNRS-UPS, LPCNO, France), B. L. Liu (Institute of Physics, Chinese Academy of Sciences, China) and we acknowledge ERC Grant No. 306719.

Geology and water resources of Owens Valley, California

USGS Publications Warehouse

Hollett, Kenneth J.; Danskin, Wesley R.; McCaffrey, William F.; Walti, Caryl L.

1991-01-01

Owens Valley, a long, narrow valley located along the east flank of the Sierra Nevada in east-central California, is the main source of water for the city of Los Angeles. The city diverts most of the surface water in the valley into the Owens River-Los Angeles Aqueduct system, which transports the water more than 200 miles south to areas of distribution and use. Additionally, ground water is pumped or flows from wells to supplement the surface-water diversions to the river-aqueduct system. Pumpage from wells needed to supplement water export has increased since 1970, when a second aqueduct was put into service, and local concerns have been expressed that the increased pumpage may have had a detrimental effect on the environment and the indigenous alkaline scrub and meadow plant communities in the valley. The scrub and meadow communities depend on soil moisture derived from precipitation and the unconfined part of a multilayered aquifer system. This report, which describes the hydrogeology of the aquifer system and the water resources of the valley, is one in a series designed to (1) evaluate the effects that groundwater pumping has on scrub and meadow communities and (2) appraise alternative strategies to mitigate any adverse effects caused by, pumping. Two principal topographic features are the surface expression of the geologic framework--the high, prominent mountains on the east and west sides of the valley and the long, narrow intermountain valley floor. The mountains are composed of sedimentary, granitic, and metamorphic rocks, mantled in part by volcanic rocks as well as by glacial, talus, and fluvial deposits. The valley floor is underlain by valley fill that consists of unconsolidated to moderately consolidated alluvial fan, transition-zone, glacial and talus, and fluvial and lacustrine deposits. The valley fill also includes interlayered recent volcanic flows and pyroclastic rocks. The bedrock surface beneath the valley fill is a narrow, steep-sided graben

Geohydrology of the Unconsolidated Valley-Fill Aquifer in the Meads Creek Valley, Schuyler and Steuben Counties, New York

USGS Publications Warehouse

Miller, Todd S.; Bugliosi, Edward F.; Reddy, James E.

2008-01-01

The Meads Creek valley encompasses 70 square miles of predominantly forested uplands in the upper Susquehanna River drainage basin. The valley, which was listed as a Priority Waterbody by the New York State Department of Environmental Conservation in 2004, is prone to periodic flooding, mostly in its downstream end, where development is occurring most rapidly. Hydraulic characteristics of the unconsolidated valley-fill aquifer were evaluated, and seepage rates in losing and gaining tributaries were calculated or estimated, in an effort to delineate the aquifer geometry and identify the factors that contribute to flooding. Results indicated that (1) Meads Creek gained about 61 cubic feet of flow per second (about 6.0 cubic feet per second per mile of stream channel) from ground-water discharge and inflow from tributaries in its 10.2-mile reach between the northernmost and southernmost measurement sites; (2) major tributaries in the northern part of the valley are not significant sources of recharge to the aquifer; and (3) major tributaries in the central and southern part of the valley provide recharge to the aquifer. The ground-water portion of streamflow in Meads Creek (excluding tributary inflow) was 11.3 cubic feet per second (ft3/s) in the central part of the valley and 17.2 ft3/s in the southern part - a total of 28.5 ft3/s. Ground-water levels were measured in 29 wells finished in unconfined deposits for construction of a potentiometric-surface map to depict directions of ground-water flow within the valley. In general, ground water flows from the edges of the valley toward Meads Creek and ultimately discharges to it. The horizontal hydraulic gradient for the entire 12-mile-long aquifer averages about 30 feet per mile, whereas the gradient in the southern fourth of the valley averages about half that - about 17 feet per mile. A water budget for the aquifer indicated that 28 percent of recharge was derived from precipitation that falls on the aquifer, 32

[Skiing and snowboarding trauma in children: epidemiology, physiopathology, prevention and main injuries].

PubMed

Dohin, B; Kohler, R

2008-11-01

Skiing and snowboarding are leading to a risk of injuries in children. Beginners and experienced have higher risk of injuries, however, the first have less severe injuries than the latest. Risk factors of injury are: ability and experience, binding adjustment, slope characteristics, speed, collisions with objects or jumping and risky behavior of the young skiers and snowboarders. Lower limb injuries are most common in skier, especially knee sprains, conversely snowboarders present more upper limb injuries, especially wrist fractures. The frequency of head injuries does not decrease while helmet use increases but severity decreases. Despite prevention and wearing protections, the frequency of trauma does not decrease significantly, which could be in relation with higher speed and increased risky behavior. Main prevention factors are safety knowledge and safety behavior, correct binding adjustment, and use of protections.

36 CFR 3.12 - May I use a vessel to tow a person for water skiing or other similar activities?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR BOATING AND WATER USE ACTIVITIES § 3.12 May I use a vessel to tow a person for water skiing or other similar activities? (a) The towing of a person... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false May I use a vessel to tow a...