Diagnosing ion-beam targets, data acquisition, reactor conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendel, Jr., C. W.

1982-01-01

The final lecture will discuss diagnostics of the target. These are very difficult because of the short times, small spatial extent, and extreme values of temperature and pressure. Diagnostics for temperature, density profile, and neutron production will be discussed. A few minutes will be devoted to data acquisition needs. The lecture will end with a discussion of current areas where improvements are needed and future diagnostics that will be required for reactor conditions.

Deveopment of Liquid Hydrogen Target and Data Acquisition System for MUSE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Briscoe, William John

The product describes the results of an R and D grant to produce a conceptual design of a liquid hydrogen target and a data acquisition for the MUSE Proton Radius Measurement at the Paul Scherrer Institute in Villigen, Switzerland.

Automated Target Acquisition, Recognition and Tracking (ATTRACT). Phase 1

NASA Technical Reports Server (NTRS)

Abdallah, Mahmoud A.

1995-01-01

The primary objective of phase 1 of this research project is to conduct multidisciplinary research that will contribute to fundamental scientific knowledge in several of the USAF critical technology areas. Specifically, neural networks, signal processing techniques, and electro-optic capabilities are utilized to solve problems associated with automated target acquisition, recognition, and tracking. To accomplish the stated objective, several tasks have been identified and were executed.

COS FUV Target Acquisition Monitor

NASA Astrophysics Data System (ADS)

Penton, Steven V.

2017-08-01

Starting in Cycle 25, the COS Target Acquisition (TA) monitor has been divided into two pieces, NUV (15389) and FUV (15386). This program is the FUV portion and is designed specifically for FUV LP4. FUV LP4 uses NUM_POS > 1 PEAKXDs for cross-dispersion TA. All previous LPs used NUM_POS=1 PEAKXDs. The NUM_POS=1 PEAKXDs required the routine monitoring of the grating-dependent WCA-to-PSA offsets. The NUM_POS >1 PEAKXDs do not use these flight software (FSW) patchable constants as they use the LTAPKD FSW macro used in ACQ/PEAKD, but re-purposed for use in the cross-dispersion (XD).This program uses the HST standard star WD1657+343. This target was used previously in the COS TA Monitor programs, 13124 (C20), 13526 (C21), 13972 (C22), 14440 (C23) & 14857 (C24). In these programs, this target was used to co-align the PSA/MIRRORB and BOA/MIRRORA ACQ/IMAGE modes. We re-use this target here as it is safe with PSA/MIRRORA and visible almost year-round.Note that when presented to the mission office, the target 206W3 was listed as the target for this program. This target was a backup target in previous TA monitor programs and was the faintest of the 3 targets in the program. Switching to the next brighter target (WD1657+343) allows all the goals of this program to be accomplished in just 2 orbits. Also, as this target has been used for every generation of this program, the FUV monitoring can be bootstrapped to previous programs, if needed. See the observing description for more details.The LTAIMAGE that started the second orbit of Visit 26 had the TDF down and the shutter closed. This caused the ACQ/IMAGE to miscenter the target by about 1.3". Visit 90 was added as a partial repeat from HOPR 89665. This visit is as close to a repeat of the 2nd orbit of Visi t 25 as possible. Due to time lost doing a full acq instead of a RE-ACQ, the following changes were made:1) Changed Visit number to 902) Schedulability set to 90%3) Before date set to Feb-19-2018, but the earlier the better

Two-Camera Acquisition and Tracking of a Flying Target

NASA Technical Reports Server (NTRS)

Biswas, Abhijit; Assad, Christopher; Kovalik, Joseph M.; Pain, Bedabrata; Wrigley, Chris J.; Twiss, Peter

2008-01-01

A method and apparatus have been developed to solve the problem of automated acquisition and tracking, from a location on the ground, of a luminous moving target in the sky. The method involves the use of two electronic cameras: (1) a stationary camera having a wide field of view, positioned and oriented to image the entire sky; and (2) a camera that has a much narrower field of view (a few degrees wide) and is mounted on a two-axis gimbal. The wide-field-of-view stationary camera is used to initially identify the target against the background sky. So that the approximate position of the target can be determined, pixel locations on the image-detector plane in the stationary camera are calibrated with respect to azimuth and elevation. The approximate target position is used to initially aim the gimballed narrow-field-of-view camera in the approximate direction of the target. Next, the narrow-field-of view camera locks onto the target image, and thereafter the gimbals are actuated as needed to maintain lock and thereby track the target with precision greater than that attainable by use of the stationary camera.

Effects of Scene Modulation Image Blur and Noise Upon Human Target Acquisition Performance.

DTIC Science & Technology

1997-06-01

AFRL-HE-WP-TR-1998-0012 UNITED STATES AIR FORCE RESEARCH LABORATORY EFFECTS OF SCENE MODULATION IMAGE BLUR AND NOISE UPON HUMAN TARGET...COVERED INTERIM (July 1996 - August 1996) TITLE AND SUBTITLE Effects of Scene Modulation Image Blur and Noise Upon Human Target Acquisition...dilemma in image transmission and display is that we must compromise between die conflicting constraints of dynamic range and noise . Three target

Cosmic Origins Spectrograph: On-Orbit Performance of Target Acquisitions

NASA Astrophysics Data System (ADS)

Penton, Steven V.

2010-07-01

COS is a slit-less spectrograph with a very small aperture (R=1.2500). To achieve the desired wavelength accuracies, HST+COS must center the target to within 0.100 of the center of the aperture for the FUV channel, and 0.0400 for NUV. During SMOV and early Cycle 17 we fine-tuned the COS target acquisition (TA) procedures to exceed this accuracy for all three COS TA modes; NUV imaging, NUV spectroscopic, and FUV spectroscopic. In Cycle 17, we also adjusted the COSto- FGS offsets in the SIAF file. This allows us to recommend skipping the time consuming ACQ/SEARCH in cases where the target coordinates are well known. Here we will compare the on-orbit performance of all COS TA modes in terms of centering accuracy, efficiency, and required signal-to-noise (S/N).

Joint Test Project Report of Combat Air Support Target Acquisition Program. SEEKVAL. Project IA2. Direct Visual Imagery Experiments.

DTIC Science & Technology

1975-01-01

Mission Zero Briefing Information ... ....... 1-A-8 Mission Zero Preflight Taped Coiments . . . 1-A-lO Mission Zero Inflight Events and Commentary . l-A...acquisitions between MAR and the target and zero range for non-acquisitions. AA 1 ... , ; "~...,, X0 ..o", xix S w...target from 35,000 feet to zero feet at nadir. If the inter-target interval was less than 35,000 feet, the device started counting on the new target

Statistical analysis of target acquisition sensor modeling experiments

NASA Astrophysics Data System (ADS)

Deaver, Dawne M.; Moyer, Steve

2015-05-01

The U.S. Army RDECOM CERDEC NVESD Modeling and Simulation Division is charged with the development and advancement of military target acquisition models to estimate expected soldier performance when using all types of imaging sensors. Two elements of sensor modeling are (1) laboratory-based psychophysical experiments used to measure task performance and calibrate the various models and (2) field-based experiments used to verify the model estimates for specific sensors. In both types of experiments, it is common practice to control or measure environmental, sensor, and target physical parameters in order to minimize uncertainty of the physics based modeling. Predicting the minimum number of test subjects required to calibrate or validate the model should be, but is not always, done during test planning. The objective of this analysis is to develop guidelines for test planners which recommend the number and types of test samples required to yield a statistically significant result.

Cycle 24 HST+COS Target Acquisition Monitor Summary

NASA Astrophysics Data System (ADS)

Penton, Steven V.; White, James

2018-06-01

HST/COS calibration program 14847 (P14857) was designed to verify that all three COS Target Acquisition (TA) modes were performing nominally during Cycle 24. The program was designed not only to determine if any of the COS TA flight software (FSW) patchable constants need updating but also to determine the values of any required parameter updates. All TA modes were determined to be performing nominally during the Cycle 24 calendar period of October 1, 2016 - October 1, 2017. No COS SIAF, TA subarray, or FSW parameter updates were required as a result of this program.

Eye Choice for Acquisition of Targets in Alternating Strabismus

PubMed Central

Economides, John R.; Adams, Daniel L.

2014-01-01

In strabismus, potentially either eye can inform the brain about the location of a target so that an accurate saccade can be made. Sixteen human subjects with alternating exotropia were tested dichoptically while viewing stimuli on a tangent screen. Each trial began with a fixation cross visible to only one eye. After the subject fixated the cross, a peripheral target visible to only one eye flashed briefly. The subject's task was to look at it. As a rule, the eye to which the target was presented was the eye that acquired the target. However, when stimuli were presented in the far nasal visual field, subjects occasionally performed a “crossover” saccade by placing the other eye on the target. This strategy avoided the need to make a large adducting saccade. In such cases, information about target location was obtained by one eye and used to program a saccade for the other eye, with a corresponding latency increase. In 10/16 subjects, targets were presented on some trials to both eyes. Binocular sensory maps were also compiled to delineate the portions of the visual scene perceived with each eye. These maps were compared with subjects' pattern of eye choice for target acquisition. There was a correspondence between suppression scotoma maps and the eye used to acquire peripheral targets. In other words, targets were fixated by the eye used to perceive them. These studies reveal how patients with alternating strabismus, despite eye misalignment, manage to localize and capture visual targets in their environment. PMID:25355212

Modeling the effects of contrast enhancement on target acquisition performance

NASA Astrophysics Data System (ADS)

Du Bosq, Todd W.; Fanning, Jonathan D.

2008-04-01

Contrast enhancement and dynamic range compression are currently being used to improve the performance of infrared imagers by increasing the contrast between the target and the scene content, by better utilizing the available gray levels either globally or locally. This paper assesses the range-performance effects of various contrast enhancement algorithms for target identification with well contrasted vehicles. Human perception experiments were performed to determine field performance using contrast enhancement on the U.S. Army RDECOM CERDEC NVESD standard military eight target set using an un-cooled LWIR camera. The experiments compare the identification performance of observers viewing linearly scaled images and various contrast enhancement processed images. Contrast enhancement is modeled in the US Army thermal target acquisition model (NVThermIP) by changing the scene contrast temperature. The model predicts improved performance based on any improved target contrast, regardless of feature saturation or enhancement. To account for the equivalent blur associated with each contrast enhancement algorithm, an additional effective MTF was calculated and added to the model. The measured results are compared with the predicted performance based on the target task difficulty metric used in NVThermIP.

Obstacle Avoidance and Target Acquisition for Robot Navigation Using a Mixed Signal Analog/Digital Neuromorphic Processing System

PubMed Central

Milde, Moritz B.; Blum, Hermann; Dietmüller, Alexander; Sumislawska, Dora; Conradt, Jörg; Indiveri, Giacomo; Sandamirskaya, Yulia

2017-01-01

Neuromorphic hardware emulates dynamics of biological neural networks in electronic circuits offering an alternative to the von Neumann computing architecture that is low-power, inherently parallel, and event-driven. This hardware allows to implement neural-network based robotic controllers in an energy-efficient way with low latency, but requires solving the problem of device variability, characteristic for analog electronic circuits. In this work, we interfaced a mixed-signal analog-digital neuromorphic processor ROLLS to a neuromorphic dynamic vision sensor (DVS) mounted on a robotic vehicle and developed an autonomous neuromorphic agent that is able to perform neurally inspired obstacle-avoidance and target acquisition. We developed a neural network architecture that can cope with device variability and verified its robustness in different environmental situations, e.g., moving obstacles, moving target, clutter, and poor light conditions. We demonstrate how this network, combined with the properties of the DVS, allows the robot to avoid obstacles using a simple biologically-inspired dynamics. We also show how a Dynamic Neural Field for target acquisition can be implemented in spiking neuromorphic hardware. This work demonstrates an implementation of working obstacle avoidance and target acquisition using mixed signal analog/digital neuromorphic hardware. PMID:28747883

Obstacle Avoidance and Target Acquisition for Robot Navigation Using a Mixed Signal Analog/Digital Neuromorphic Processing System.

PubMed

Milde, Moritz B; Blum, Hermann; Dietmüller, Alexander; Sumislawska, Dora; Conradt, Jörg; Indiveri, Giacomo; Sandamirskaya, Yulia

2017-01-01

Neuromorphic hardware emulates dynamics of biological neural networks in electronic circuits offering an alternative to the von Neumann computing architecture that is low-power, inherently parallel, and event-driven. This hardware allows to implement neural-network based robotic controllers in an energy-efficient way with low latency, but requires solving the problem of device variability, characteristic for analog electronic circuits. In this work, we interfaced a mixed-signal analog-digital neuromorphic processor ROLLS to a neuromorphic dynamic vision sensor (DVS) mounted on a robotic vehicle and developed an autonomous neuromorphic agent that is able to perform neurally inspired obstacle-avoidance and target acquisition. We developed a neural network architecture that can cope with device variability and verified its robustness in different environmental situations, e.g., moving obstacles, moving target, clutter, and poor light conditions. We demonstrate how this network, combined with the properties of the DVS, allows the robot to avoid obstacles using a simple biologically-inspired dynamics. We also show how a Dynamic Neural Field for target acquisition can be implemented in spiking neuromorphic hardware. This work demonstrates an implementation of working obstacle avoidance and target acquisition using mixed signal analog/digital neuromorphic hardware.

Cosmic Origins Spectrograph : Target Acquisition Performance and Updated Guidelines

NASA Astrophysics Data System (ADS)

Penton, Steven V.; Keyes, C.; Osterman, S.; Sahnow, D.; Soderblom, D.; COS IDT Team; STScI COS Team

2010-01-01

The Cosmic Origins Spectrograph (COS) is a slit-less spectrograph with a very small aperture (radius = 1.25"). To achieve the desired wavelength accuracy of <15 km/s, HST+COS must center the target to within 0.1” of the center of the aperture. This is the angle subtended by a typical AAS poster when viewed from over 1400 miles away. During SMOV we have fine-tuned the COS target acquisition (TA) procedures to exceed this accuracy for all three COS TA modes; NUV imaging, NUV spectroscopic, and FUV spectroscopic. We will compare all COS TA modes in terms of centering accuracy, efficiency (elapsed time), and required signal-to-noise for all targets suitable for use with COS. We will also provide updated recommendations for the options of all TA modes (e.g., SCAN-SIZE and NUM-POS of ACQ/PEAKD). We have observed in SMOV that HST is providing an excellent initial 1-σ blind pointing accuracy of ±0.4” in both the along-dispersion and cross-dispersion directions. We will discuss the implications of this, and other lessons learned in SMOV, on Cycle 17 and 18 HST+COS TAs.

Target recognition and phase acquisition by using incoherent digital holographic imaging

NASA Astrophysics Data System (ADS)

Lee, Munseob; Lee, Byung-Tak

2017-05-01

In this study, we proposed the Incoherent Digital Holographic Imaging (IDHI) for recognition and phase information of dedicated target. Although recent development of a number of target recognition techniques such as LIDAR, there have limited success in target discrimination, in part due to low-resolution, low scanning speed, and computation power. In the paper, the proposed system consists of the incoherent light source, such as LED, Michelson interferometer, and digital CCD for acquisition of four phase shifting image. First of all, to compare with relative coherence, we used a source as laser and LED, respectively. Through numerical reconstruction by using the four phase shifting method and Fresnel diffraction method, we recovered the intensity and phase image of USAF resolution target apart from about 1.0m distance. In this experiment, we show 1.2 times improvement in resolution compared to conventional imaging. Finally, to confirm the recognition result of camouflaged targets with the same color from background, we carry out to test holographic imaging in incoherent light. In this result, we showed the possibility of a target detection and recognition that used three dimensional shape and size signatures, numerical distance from phase information of obtained holographic image.

COS Target Acquisition Guidelines, Recommendations, and Interpretation

NASA Astrophysics Data System (ADS)

Keyes, Charles (Tony) D.; Penton, Steven V.

2010-06-01

Based upon analysis of SMOV and Cycle 17 observations through April 2010, this ISR expands, updates, and supersedes recommendations and information provided about target acquisitions (TA) in the COS Instrument Handbook version 2. This ISR provides an overview of COS TA, presents general guidelines and recommendations for crafting COS TAs, establishes COS TA centering accuracy requirements to achieve COS photometric, velocity, and resolution objectives, and summarizes the performance of the COS on-board TA modes as compared to these centering requirements. Updated TA strategy recommendations are given where appropriate, a user-oriented table lists where to find important quantities for the analysis and interpretation of COS TAs, and a brief appendix with additional supporting information is included. An overview of COS TA strategies is provided in Section 2 and Table 1; important updates to ACQ/SEARCH requirements and SEARCH-SIZE recommendations as a function of target coordinate accuracy are given in Tables 2 and 3; COS TA performance by mode is described in Section 5; important header keywords that are useful for evaluating the quality of COS TAs are listed in Table 5 along with where to find them; Table 6 gives a summary of COS TA modes, options, and recommended values; Section 7 summarizes updated recommendations and guidelines for COS TA; and Appendix A provides additional useful COS TA information.

Improved Quantitative Plant Proteomics via the Combination of Targeted and Untargeted Data Acquisition

PubMed Central

Hart-Smith, Gene; Reis, Rodrigo S.; Waterhouse, Peter M.; Wilkins, Marc R.

2017-01-01

Quantitative proteomics strategies – which are playing important roles in the expanding field of plant molecular systems biology – are traditionally designated as either hypothesis driven or non-hypothesis driven. Many of these strategies aim to select individual peptide ions for tandem mass spectrometry (MS/MS), and to do this mixed hypothesis driven and non-hypothesis driven approaches are theoretically simple to implement. In-depth investigations into the efficacies of such approaches have, however, yet to be described. In this study, using combined samples of unlabeled and metabolically 15N-labeled Arabidopsis thaliana proteins, we investigate the mixed use of targeted data acquisition (TDA) and data dependent acquisition (DDA) – referred to as TDA/DDA – to facilitate both hypothesis driven and non-hypothesis driven quantitative data collection in individual LC-MS/MS experiments. To investigate TDA/DDA for hypothesis driven data collection, 7 miRNA target proteins of differing size and abundance were targeted using inclusion lists comprised of 1558 m/z values, using 3 different TDA/DDA experimental designs. In samples in which targeted peptide ions were of particularly low abundance (i.e., predominantly only marginally above mass analyser detection limits), TDA/DDA produced statistically significant increases in the number of targeted peptides identified (230 ± 8 versus 80 ± 3 for DDA; p = 1.1 × 10-3) and quantified (35 ± 3 versus 21 ± 2 for DDA; p = 0.038) per experiment relative to the use of DDA only. These expected improvements in hypothesis driven data collection were observed alongside unexpected improvements in non-hypothesis driven data collection. Untargeted peptide ions with m/z values matching those in inclusion lists were repeatedly identified and quantified across technical replicate TDA/DDA experiments, resulting in significant increases in the percentages of proteins repeatedly quantified in TDA/DDA experiments only relative to DDA

Modeling the target acquisition performance of active imaging systems

NASA Astrophysics Data System (ADS)

Espinola, Richard L.; Jacobs, Eddie L.; Halford, Carl E.; Vollmerhausen, Richard; Tofsted, David H.

2007-04-01

Recent development of active imaging system technology in the defense and security community have driven the need for a theoretical understanding of its operation and performance in military applications such as target acquisition. In this paper, the modeling of active imaging systems, developed at the U.S. Army RDECOM CERDEC Night Vision & Electronic Sensors Directorate, is presented with particular emphasis on the impact of coherent effects such as speckle and atmospheric scintillation. Experimental results from human perception tests are in good agreement with the model results, validating the modeling of coherent effects as additional noise sources. Example trade studies on the design of a conceptual active imaging system to mitigate deleterious coherent effects are shown.

Modeling the target acquisition performance of active imaging systems.

PubMed

Espinola, Richard L; Jacobs, Eddie L; Halford, Carl E; Vollmerhausen, Richard; Tofsted, David H

2007-04-02

Recent development of active imaging system technology in the defense and security community have driven the need for a theoretical understanding of its operation and performance in military applications such as target acquisition. In this paper, the modeling of active imaging systems, developed at the U.S. Army RDECOM CERDEC Night Vision & Electronic Sensors Directorate, is presented with particular emphasis on the impact of coherent effects such as speckle and atmospheric scintillation. Experimental results from human perception tests are in good agreement with the model results, validating the modeling of coherent effects as additional noise sources. Example trade studies on the design of a conceptual active imaging system to mitigate deleterious coherent effects are shown.

Role of quality of service metrics in visual target acquisition and tracking in resource constrained environments

NASA Astrophysics Data System (ADS)

Anderson, Monica; David, Phillip

2007-04-01

Implementation of an intelligent, automated target acquisition and tracking systems alleviates the need for operators to monitor video continuously. This system could identify situations that fatigued operators could easily miss. If an automated acquisition and tracking system plans motions to maximize a coverage metric, how does the performance of that system change when the user intervenes and manually moves the camera? How can the operator give input to the system about what is important and understand how that relates to the overall task balance between surveillance and coverage? In this paper, we address these issues by introducing a new formulation of the average linear uncovered length (ALUL) metric, specially designed for use in surveilling urban environments. This metric coordinates the often competing goals of acquiring new targets and tracking existing targets. In addition, it provides current system performance feedback to system users in terms of the system's theoretical maximum and minimum performance. We show the successful integration of the algorithm via simulation.

LWIR hyperspectral change detection for target acquisition and situation awareness in urban areas

NASA Astrophysics Data System (ADS)

Dekker, Rob J.; Schwering, Piet B. W.; Benoist, Koen W.; Pignatti, Stefano; Santini, Federico; Friman, Ola

2013-05-01

This paper studies change detection of LWIR (Long Wave Infrared) hyperspectral imagery. Goal is to improve target acquisition and situation awareness in urban areas with respect to conventional techniques. Hyperspectral and conventional broadband high-spatial-resolution data were collected during the DUCAS trials in Zeebrugge, Belgium, in June 2011. LWIR data were acquired using the ITRES Thermal Airborne Spectrographic Imager TASI-600 that operates in the spectral range of 8.0-11.5 μm (32 band configuration). Broadband data were acquired using two aeroplanemounted FLIR SC7000 MWIR cameras. Acquisition of the images was around noon. To limit the number of false alarms due to atmospheric changes, the time interval between the images is less than 2 hours. Local co-registration adjustment was applied to compensate for misregistration errors in the order of a few pixels. The targets in the data that will be analysed in this paper are different kinds of vehicles. Change detection algorithms that were applied and evaluated are Euclidean distance, Mahalanobis distance, Chronochrome (CC), Covariance Equalisation (CE), and Hyperbolic Anomalous Change Detection (HACD). Based on Receiver Operating Characteristics (ROC) we conclude that LWIR hyperspectral has an advantage over MWIR broadband change detection. The best hyperspectral detector is HACD because it is most robust to noise. MWIR high spatial-resolution broadband results show that it helps to apply a false alarm reduction strategy based on spatial processing.

The MROI fast tip-tilt correction and target acquisition system

NASA Astrophysics Data System (ADS)

Young, John; Buscher, David; Fisher, Martin; Haniff, Christopher; Rea, Alexander; Seneta, Eugene B.; Sun, Xiaowei; Wilson, Donald; Farris, Allen; Olivares, Andres; Selina, Robert

2012-07-01

The fast tip-tilt correction system for the Magdalena Ridge Observatory Interferometer (MROI) is being designed and fabricated by the University of Cambridge. The design of the system is currently at an advanced stage and the performance of its critical subsystems has been verified in the laboratory. The system has been designed to meet a demanding set of specifications including satisfying all performance requirements in ambient temperatures down to -5 °C, maintaining the stability of the tip-tilt fiducial over a 5 °C temperature change without recourse to an optical reference, and a target acquisition mode with a 60” field-of-view. We describe the important technical features of the system, which uses an Andor electron-multiplying CCD camera protected by a thermal enclosure, a transmissive optical system with mounts incorporating passive thermal compensation, and custom control software running under Xenomai real-time Linux. We also report results from laboratory tests that demonstrate (a) the high stability of the custom optic mounts and (b) the low readout and compute latencies that will allow us to achieve a 40 Hz closed-loop bandwidth on bright targets.

Using Data Independent Acquisition (DIA) to Model High-responding Peptides for Targeted Proteomics Experiments*

PubMed Central

Searle, Brian C.; Egertson, Jarrett D.; Bollinger, James G.; Stergachis, Andrew B.; MacCoss, Michael J.

2015-01-01

Targeted mass spectrometry is an essential tool for detecting quantitative changes in low abundant proteins throughout the proteome. Although selected reaction monitoring (SRM) is the preferred method for quantifying peptides in complex samples, the process of designing SRM assays is laborious. Peptides have widely varying signal responses dictated by sequence-specific physiochemical properties; one major challenge is in selecting representative peptides to target as a proxy for protein abundance. Here we present PREGO, a software tool that predicts high-responding peptides for SRM experiments. PREGO predicts peptide responses with an artificial neural network trained using 11 minimally redundant, maximally relevant properties. Crucial to its success, PREGO is trained using fragment ion intensities of equimolar synthetic peptides extracted from data independent acquisition experiments. Because of similarities in instrumentation and the nature of data collection, relative peptide responses from data independent acquisition experiments are a suitable substitute for SRM experiments because they both make quantitative measurements from integrated fragment ion chromatograms. Using an SRM experiment containing 12,973 peptides from 724 synthetic proteins, PREGO exhibits a 40–85% improvement over previously published approaches at selecting high-responding peptides. These results also represent a dramatic improvement over the rules-based peptide selection approaches commonly used in the literature. PMID:26100116

Second COS FUV Lifetime Position: FUV Target Acquisition Parameter Update {FENA4}

NASA Astrophysics Data System (ADS)

Penton, Steven

2011-10-01

Verify the ability of the Cycle 20 COS FSW to place an isolated point source at the center of the PSA, using FUV dispersed light target acquisition {TA} from the object and all three FUV gratings at the Second Lifetime Position {SLP}. This program is modeled from the activity summary of FENA4.This program should be executed after the new HV, XD spectral positions, and focus are determined and updated. In addition, the LIFETIME=ALTERNATE TA FSW parameters should be updated prior to execution of this program.NUV imaging TAs have previously been used to determine the correct locations for FUV spectra. We follow the same procedure here.

Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum

PubMed Central

Leal, Sixto M.; Roy, Sanhita; Vareechon, Chairut; Carrion, Steven deJesus; Clark, Heather; Lopez-Berges, Manuel S.; diPietro, Antonio; Schrettl, Marcus; Beckmann, Nicola; Redl, Bernhard; Haas, Hubertus; Pearlman, Eric

2013-01-01

Filamentous fungi are an important cause of pulmonary and systemic morbidity and mortality, and also cause corneal blindness and visual impairment worldwide. Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 production regulates expression of iron chelators, heme and siderophore binding proteins and hepcidin in infected mice. In addition, we show that human neutrophils synthesize lipocalin-1, which sequesters fungal siderophores, and that topical lipocalin-1 or lactoferrin restricts fungal growth in vivo. Conversely, we show that exogenous iron or the xenosiderophore deferroxamine enhances fungal growth in infected mice. By examining mutant Aspergillus and Fusarium strains, we found that fungal transcriptional responses to low iron levels and extracellular siderophores are essential for fungal growth during infection. Further, we showed that targeting fungal iron acquisition or siderophore biosynthesis by topical application of iron chelators or statins reduces fungal growth in the cornea by 60% and that dual therapy with the iron chelator deferiprone and statins further restricts fungal growth by 75%. Together, these studies identify specific host iron-chelating and fungal iron-acquisition mediators that regulate fungal growth, and demonstrate that therapeutic inhibition of fungal iron acquisition can be utilized to treat topical fungal infections. PMID:23853581

Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.

PubMed

Leal, Sixto M; Roy, Sanhita; Vareechon, Chairut; Carrion, Steven deJesus; Clark, Heather; Lopez-Berges, Manuel S; Di Pietro, Antonio; diPietro, Antonio; Schrettl, Marcus; Beckmann, Nicola; Redl, Bernhard; Haas, Hubertus; Pearlman, Eric

2013-01-01

Filamentous fungi are an important cause of pulmonary and systemic morbidity and mortality, and also cause corneal blindness and visual impairment worldwide. Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 production regulates expression of iron chelators, heme and siderophore binding proteins and hepcidin in infected mice. In addition, we show that human neutrophils synthesize lipocalin-1, which sequesters fungal siderophores, and that topical lipocalin-1 or lactoferrin restricts fungal growth in vivo. Conversely, we show that exogenous iron or the xenosiderophore deferroxamine enhances fungal growth in infected mice. By examining mutant Aspergillus and Fusarium strains, we found that fungal transcriptional responses to low iron levels and extracellular siderophores are essential for fungal growth during infection. Further, we showed that targeting fungal iron acquisition or siderophore biosynthesis by topical application of iron chelators or statins reduces fungal growth in the cornea by 60% and that dual therapy with the iron chelator deferiprone and statins further restricts fungal growth by 75%. Together, these studies identify specific host iron-chelating and fungal iron-acquisition mediators that regulate fungal growth, and demonstrate that therapeutic inhibition of fungal iron acquisition can be utilized to treat topical fungal infections.

Evaluation of target acquisition difficulty using recognition distance to measure required retinal area

NASA Astrophysics Data System (ADS)

Nilsson, Thomy H.

2001-09-01

The psychophysical method of limits was used to measure the distance at which observers could distinguish military vehicles photographed in natural landscapes. Obtained from the TNO-TM Search_2 dataset, these pictures either were rear-projected 35-mm slides or were presented on a computer monitor. Based on the rationale that more difficult vehicle targets would require more visual pathways for recognition, difficult of acquisition was defined in terms of the relative retinal area required for recognition. Relative retinal area was derived from the inverse square of the recognition distance of a particular vehicle relative to the distance of the vehicle that could be seen furthest away. Results are compared with data on the time required to find the vehicles in these pictures. These comparison indicate recognition distance thresholds can be a suitable means of defining standards for the effectiveness of vital graphic information; and the two methods are complementary with respect to distinguishing different degrees of acquisition difficulty, and together may provide a means to measure the total information processing required for recognition.

Assisting People with Multiple Disabilities by Improving Their Computer Pointing Efficiency with an Automatic Target Acquisition Program

ERIC Educational Resources Information Center

Shih, Ching-Hsiang; Shih, Ching-Tien; Peng, Chin-Ling

2011-01-01

This study evaluated whether two people with multiple disabilities would be able to improve their pointing performance through an Automatic Target Acquisition Program (ATAP) and a newly developed mouse driver (i.e. a new mouse driver replaces standard mouse driver, and is able to monitor mouse movement and intercept click action). Initially, both…

Targeting Alertness to Improve Cognition in Older Adults: A Preliminary Report of Benefits in Executive Function and Skill Acquisition

PubMed Central

Van Vleet, Thomas M.; DeGutis, Joseph M.; Merzenich, Michael M.; Simpson, Gregory V.; Zomet, Ativ; Dabit, Sawsan

2016-01-01

Efficient self-regulation of alertness declines with age exacerbating normal declines in performance across multiple cognitive domains, including learning and skill acquisition. Previous cognitive intervention studies have shown that it is possible to enhance alertness in patients with acquired brain injury and marked attention impairments, and that this benefit generalizes to improvements in more global cognitive functions. In the current preliminary studies, we sought to test whether this approach, that targets both tonic (over a period of minutes) and phasic (moment-to-moment) alertness, can improve key executive functioning declines in older adults, and enhance the rate of skill acquisition. The results of both experiments 1 and 2 demonstrate that, compared to active control training, alertness training significantly enhanced performance in several validated executive function measures. In experiment 2, alertness training significantly improved skill acquisition compared to active control training in a well-characterized speed of processing task, with the largest benefits shown in the most challenging speed of processing blocks. The results of the current study suggest that targeting intrinsic alertness in cognitive training provides a novel approach to improve executive functions in older adults and may be a useful adjunct treatment to enhance benefits gained in other clinically validated treatments. PMID:27372902

Evaluation of a modified Fitts law brain-computer interface target acquisition task in able and motor disabled individuals

NASA Astrophysics Data System (ADS)

Felton, E. A.; Radwin, R. G.; Wilson, J. A.; Williams, J. C.

2009-10-01

A brain-computer interface (BCI) is a communication system that takes recorded brain signals and translates them into real-time actions, in this case movement of a cursor on a computer screen. This work applied Fitts' law to the evaluation of performance on a target acquisition task during sensorimotor rhythm-based BCI training. Fitts' law, which has been used as a predictor of movement time in studies of human movement, was used here to determine the information transfer rate, which was based on target acquisition time and target difficulty. The information transfer rate was used to make comparisons between control modalities and subject groups on the same task. Data were analyzed from eight able-bodied and five motor disabled participants who wore an electrode cap that recorded and translated their electroencephalogram (EEG) signals into computer cursor movements. Direct comparisons were made between able-bodied and disabled subjects, and between EEG and joystick cursor control in able-bodied subjects. Fitts' law aptly described the relationship between movement time and index of difficulty for each task movement direction when evaluated separately and averaged together. This study showed that Fitts' law can be successfully applied to computer cursor movement controlled by neural signals.

Target acquisition modeling over the exact optical path: extending the EOSTAR TDA with the TOD sensor performance model

NASA Astrophysics Data System (ADS)

Dijk, J.; Bijl, P.; Oppeneer, M.; ten Hove, R. J. M.; van Iersel, M.

2017-10-01

The Electro-Optical Signal Transmission and Ranging (EOSTAR) model is an image-based Tactical Decision Aid (TDA) for thermal imaging systems (MWIR/LWIR) developed for a sea environment with an extensive atmosphere model. The Triangle Orientation Discrimination (TOD) Target Acquisition model calculates the sensor and signal processing effects on a set of input triangle test pattern images, judges their orientation using humans or a Human Visual System (HVS) model and derives the system image quality and operational field performance from the correctness of the responses. Combination of the TOD model and EOSTAR, basically provides the possibility to model Target Acquisition (TA) performance over the exact path from scene to observer. In this method ship representative TOD test patterns are placed at the position of the real target, subsequently the combined effects of the environment (atmosphere, background, etc.), sensor and signal processing on the image are calculated using EOSTAR and finally the results are judged by humans. The thresholds are converted into Detection-Recognition-Identification (DRI) ranges of the real target. In experiments is shown that combination of the TOD model and the EOSTAR model is indeed possible. The resulting images look natural and provide insight in the possibilities of combining the two models. The TOD observation task can be done well by humans, and the measured TOD is consistent with analytical TOD predictions for the same camera that was modeled in the ECOMOS project.

Generation of data acquisition requests for the ASTER satellite instrument for monitoring a globally distributed target: glaciers

USGS Publications Warehouse

Raup, B.H.; Kieffer, H.H.; Hare, T.M.; Kargel, J.S.

2000-01-01

The advanced spaceborne thermal emission and reflection radiometer (ASTER) instrument is scheduled to be launched on the EOS Terra platform in 1999. The Global Land Ice Measurements from Space project has planned to acquire ASTER images of most of the world's land ice annually during the six-year ASTER mission. This article describes the process of creating the data acquisition requests needed to cover approximately 170,000 glacier targets.

Networked sensors for the combat forces

NASA Astrophysics Data System (ADS)

Klager, Gene

2004-11-01

Real-time and detailed information is critical to the success of ground combat forces. Current manned reconnaissance, surveillance, and target acquisition (RSTA) capabilities are not sufficient to cover battlefield intelligence gaps, provide Beyond-Line-of-Sight (BLOS) targeting, and the ambush avoidance information necessary for combat forces operating in hostile situations, complex terrain, and conducting military operations in urban terrain. This paper describes a current US Army program developing advanced networked unmanned/unattended sensor systems to survey these gaps and provide the Commander with real-time, pertinent information. Networked Sensors for the Combat Forces plans to develop and demonstrate a new generation of low cost distributed unmanned sensor systems organic to the RSTA Element. Networked unmanned sensors will provide remote monitoring of gaps, will increase a unit"s area of coverage, and will provide the commander organic assets to complete his Battlefield Situational Awareness (BSA) picture for direct and indirect fire weapons, early warning, and threat avoidance. Current efforts include developing sensor packages for unmanned ground vehicles, small unmanned aerial vehicles, and unattended ground sensors using advanced sensor technologies. These sensors will be integrated with robust networked communications and Battle Command tools for mission planning, intelligence "reachback", and sensor data management. The network architecture design is based on a model that identifies a three-part modular design: 1) standardized sensor message protocols, 2) Sensor Data Management, and 3) Service Oriented Architecture. This simple model provides maximum flexibility for data exchange, information management and distribution. Products include: Sensor suites optimized for unmanned platforms, stationary and mobile versions of the Sensor Data Management Center, Battle Command planning tools, networked communications, and sensor management software. Details

Acoustic window planning for ultrasound acquisition.

PubMed

Göbl, Rüdiger; Virga, Salvatore; Rackerseder, Julia; Frisch, Benjamin; Navab, Nassir; Hennersperger, Christoph

2017-06-01

Autonomous robotic ultrasound has recently gained considerable interest, especially for collaborative applications. Existing methods for acquisition trajectory planning are solely based on geometrical considerations, such as the pose of the transducer with respect to the patient surface. This work aims at establishing acoustic window planning to enable autonomous ultrasound acquisitions of anatomies with restricted acoustic windows, such as the liver or the heart. We propose a fully automatic approach for the planning of acquisition trajectories, which only requires information about the target region as well as existing tomographic imaging data, such as X-ray computed tomography. The framework integrates both geometrical and physics-based constraints to estimate the best ultrasound acquisition trajectories with respect to the available acoustic windows. We evaluate the developed method using virtual planning scenarios based on real patient data as well as for real robotic ultrasound acquisitions on a tissue-mimicking phantom. The proposed method yields superior image quality in comparison with a naive planning approach, while maintaining the necessary coverage of the target. We demonstrate that by taking image formation properties into account acquisition planning methods can outperform naive plannings. Furthermore, we show the need for such planning techniques, since naive approaches are not sufficient as they do not take the expected image quality into account.

A robust close-range photogrammetric target extraction algorithm for size and type variant targets

NASA Astrophysics Data System (ADS)

Nyarko, Kofi; Thomas, Clayton; Torres, Gilbert

2016-05-01

The Photo-G program conducted by Naval Air Systems Command at the Atlantic Test Range in Patuxent River, Maryland, uses photogrammetric analysis of large amounts of real-world imagery to characterize the motion of objects in a 3-D scene. Current approaches involve several independent processes including target acquisition, target identification, 2-D tracking of image features, and 3-D kinematic state estimation. Each process has its own inherent complications and corresponding degrees of both human intervention and computational complexity. One approach being explored for automated target acquisition relies on exploiting the pixel intensity distributions of photogrammetric targets, which tend to be patterns with bimodal intensity distributions. The bimodal distribution partitioning algorithm utilizes this distribution to automatically deconstruct a video frame into regions of interest (ROI) that are merged and expanded to target boundaries, from which ROI centroids are extracted to mark target acquisition points. This process has proved to be scale, position and orientation invariant, as well as fairly insensitive to global uniform intensity disparities.

Feature long axis size and local luminance contrast determine ship target acquisition performance: strong evidence for the TOD case

NASA Astrophysics Data System (ADS)

Bijl, Piet; Toet, Alexander; Kooi, Frank L.

2016-10-01

Visual images of a civilian target ship on a sea background were produced using a CAD model. The total set consisted of 264 images and included 3 different color schemes, 2 ship viewing aspects, 5 sun illumination conditions, 2 sea reflection values, 2 ship positions with respect to the horizon and 3 values of atmospheric contrast reduction. In a perception experiment, the images were presented on a display in a long darkened corridor. Observers were asked to indicate the range at which they were able to detect the ship and classify the following 5 ship elements: accommodation, funnel, hull, mast, and hat above the bridge. This resulted in a total of 1584 Target Acquisition (TA) range estimates for two observers. Next, the ship contour, ship elements and corresponding TA ranges were analyzed applying several feature size and contrast measures. Most data coincide on a contrast versus angular size plot using (1) the long axis as characteristic ship/ship feature size and (2) local Weber contrast as characteristic ship/ship feature contrast. Finally, the data were compared with a variety of visual performance functions assumed to be representative for Target Acquisition: the TOD (Triangle Orientation Discrimination), MRC (Minimum Resolvable Contrast), CTF (Contrast Threshold Function), TTP (Targeting Task Performance) metric and circular disc detection data for the unaided eye (Blackwell). The results provide strong evidence for the TOD case: both position and slope of the TOD curve match the ship detection and classification data without any free parameter. In contrast, the MRC and CTF are too steep, the TTP and disc detection curves are too shallow and all these curves need an overall scaling factor in order to coincide with the ship and ship feature recognition data.

78 FR 55241 - Corrosion-Resistant Carbon Steel Flat Products From the Republic of Korea: Preliminary Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-10

... for Parts and Materials B. Restriction of Special Taxation Act (``RSTA'') Article 26 C. Asset... A. Tax Credits Received Under the Restriction of Special Taxation Act (``RSTA'') 9. Conclusion [FR...

Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics.

PubMed

Peckner, Ryan; Myers, Samuel A; Jacome, Alvaro Sebastian Vaca; Egertson, Jarrett D; Abelin, Jennifer G; MacCoss, Michael J; Carr, Steven A; Jaffe, Jacob D

2018-05-01

Mass spectrometry with data-independent acquisition (DIA) is a promising method to improve the comprehensiveness and reproducibility of targeted and discovery proteomics, in theory by systematically measuring all peptide precursors in a biological sample. However, the analytical challenges involved in discriminating between peptides with similar sequences in convoluted spectra have limited its applicability in important cases, such as the detection of single-nucleotide polymorphisms (SNPs) and alternative site localizations in phosphoproteomics data. We report Specter (https://github.com/rpeckner-broad/Specter), an open-source software tool that uses linear algebra to deconvolute DIA mixture spectra directly through comparison to a spectral library, thus circumventing the problems associated with typical fragment-correlation-based approaches. We validate the sensitivity of Specter and its performance relative to that of other methods, and show that Specter is able to successfully analyze cases involving highly similar peptides that are typically challenging for DIA analysis methods.

Development and Validation of a Qualitative Method for Target Screening of 448 Pesticide Residues in Fruits and Vegetables Using UHPLC/ESI Q-Orbitrap Based on Data-Independent Acquisition and Compound Database.

PubMed

Wang, Jian; Chow, Willis; Chang, James; Wong, Jon W

2017-01-18

A semiautomated qualitative method for target screening of 448 pesticide residues in fruits and vegetables was developed and validated using ultrahigh-performance liquid chromatography coupled with electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC/ESI Q-Orbitrap). The Q-Orbitrap Full MS/dd-MS 2 (data dependent acquisition) was used to acquire product-ion spectra of individual pesticides to build a compound database or an MS library, while its Full MS/DIA (data independent acquisition) was utilized for sample data acquisition from fruit and vegetable matrices fortified with pesticides at 10 and 100 μg/kg for target screening purpose. Accurate mass, retention time and response threshold were three key parameters in a compound database that were used to detect incurred pesticide residues in samples. The concepts and practical aspects of in-spectrum mass correction or solvent background lock-mass correction, retention time alignment and response threshold adjustment are discussed while building a functional and working compound database for target screening. The validated target screening method is capable of screening at least 94% and 99% of 448 pesticides at 10 and 100 μg/kg, respectively, in fruits and vegetables without having to evaluate every compound manually during data processing, which significantly reduced the workload in routine practice.

On the acquisition and representation of procedural knowledge

NASA Technical Reports Server (NTRS)

Saito, T.; Ortiz, C.; Loftin, R. B.

1992-01-01

Historically knowledge acquisition has proven to be one of the greatest barriers to the development of intelligent systems. Current practice generally requires lengthy interactions between the expert whose knowledge is to be captured and the knowledge engineer whose responsibility is to acquire and represent knowledge in a useful form. Although much research has been devoted to the development of methodologies and computer software to aid in the capture and representation of some of some types of knowledge, little attention has been devoted to procedural knowledge. NASA personnel frequently perform tasks that are primarily procedural in nature. Previous work is reviewed in the field of knowledge acquisition and then focus on knowledge acquisition for procedural tasks with special attention devoted to the Navy's VISTA tool. The design and development is described of a system for the acquisition and representation of procedural knowledge-TARGET (Task Analysis and Rule Generation Tool). TARGET is intended as a tool that permits experts to visually describe procedural tasks and as a common medium for knowledge refinement by the expert and knowledge engineer. The system is designed to represent the acquired knowledge in the form of production rules. Systems such as TARGET have the potential to profoundly reduce the time, difficulties, and costs of developing knowledge-based systems for the performance of procedural tasks.

DART -- Data acquisition for the next generation of Fermilab fixed target experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oleynik, G.; Anderson, J.; Appleton, L.

1994-02-01

DART is the name of the data acquisition effort for Fermilab experiments taking data in the '94--'95 time frame and beyond. Its charge is to provide a common system of hardware and software, which can be easily configured and extended to meet the wide range of data acquisition requirements of the experiments. Its strategy is to provide incrementally functional data acquisition systems to the experiments at frequent intervals to support the ongoing DA activities of the experiments. DART is a collaborative development effort between the experimenters and the Fermilab Computing Division. Experiments collaborating in DART cover a range of requirementsmore » from 400 Kbytes/sec event readout using a single DA processor, to 200 Mbytes/sec event readout involving 10 parallel readout streams, 10 VME event building planes and greater than 1,000 MIPs of event filter processing. The authors describe the requirements, architecture, and plans for the project and report on its current status.« less

48 CFR 52.216-17 - Incentive Price Revision-Successive Targets.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-Successive Targets. 52.216-17 Section 52.216-17 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.216-17 Incentive Price Revision—Successive Targets. As prescribed in 16.406(b), insert the following clause: Incentive Price Revision—Successive Targets (OCT 1997) (a) General. The supplies or...

48 CFR 52.216-17 - Incentive Price Revision-Successive Targets.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-Successive Targets. 52.216-17 Section 52.216-17 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.216-17 Incentive Price Revision—Successive Targets. As prescribed in 16.406(b), insert the following clause: Incentive Price Revision—Successive Targets (OCT 1997) (a) General. The supplies or...

48 CFR 52.216-16 - Incentive Price Revision-Firm Target.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-Firm Target. 52.216-16 Section 52.216-16 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.216-16 Incentive Price Revision—Firm Target. As prescribed in 16.406(a), insert the following clause: Incentive Price Revision—Firm Target (OCT 1997) (a) General. The supplies or services identified...

48 CFR 52.216-16 - Incentive Price Revision-Firm Target.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-Firm Target. 52.216-16 Section 52.216-16 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.216-16 Incentive Price Revision—Firm Target. As prescribed in 16.406(a), insert the following clause: Incentive Price Revision—Firm Target (OCT 1997) (a) General. The supplies or services identified...

48 CFR 216.403-1 - Fixed-price incentive (firm target) contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... (firm target) contracts. 216.403-1 Section 216.403-1 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-1 Fixed-price incentive (firm target) contracts. (b) Application. (1... target) contracts, especially for acquisitions moving from development to production. (2) The contracting...

Third COS FUV Lifetime Position: FUV Target Acquisition Parameter Update {LENA3}

NASA Astrophysics Data System (ADS)

Penton, Steven

2013-10-01

Verify the ability of the Cycle 22 COS FSW to place an isolated point source at the center of the PSA, using FUV dispersed light target acquisition (TA) from the object and all three FUV gratings at the Third Lifetime Position (LP3). This program is modeled from the activity summary of LENA3.This program should be executed after the LP3 HV, XD spectral positions, aperture mechanism position, and focus are determined and updated. In addition, initial estimates of the LIFETIME=ALTERNATE TA FSW parameters and subarrays should be updated prior to execution of this program. After Visit 01, the subarrays will be updated. After Visit 2, the FUV WCA-to-PSA offsets will be updateded. Prior to Visit 6, LV56 will be installed will include new values for the LP3 FUV plate scales. VISIT 6 exposures use the default lifetime position (LP3).NUV imaging TAs have previously been used to determine the correct locations for FUV spectra. We follow the same procedure here.Note that the ETC runs here were made using ETC22.2 and are therefore valid for Mach 2014. Some TDS drop will likely have occured before these visits execute, but we have plenty of count to go what we need to do in this program.

Autonomous Surface Sample Acquisition for Planetary and Lunar Exploration

NASA Astrophysics Data System (ADS)

Barnes, D. P.

2007-08-01

Surface science sample acquisition is a critical activity within any planetary and lunar exploration mission, and our research is focused upon the design, implementation, experimentation and demonstration of an onboard autonomous surface sample acquisition capability for a rover equipped with a robotic arm upon which are mounted appropriate science instruments. Images captured by a rover stereo camera system can be processed using shape from stereo methods and a digital elevation model (DEM) generated. We have developed a terrain feature identification algorithm that can determine autonomously from DEM data suitable regions for instrument placement and/or surface sample acquisition. Once identified, surface normal data can be generated autonomously which are then used to calculate an arm trajectory for instrument placement and sample acquisition. Once an instrument placement and sample acquisition trajectory has been calculated, a collision detection algorithm is required to ensure the safe operation of the arm during sample acquisition.We have developed a novel adaptive 'bounding spheres' approach to this problem. Once potential science targets have been identified, and these are within the reach of the arm and will not cause any undesired collision, then the 'cost' of executing the sample acquisition activity is required. Such information which includes power expenditure and duration can be used to select the 'best' target from a set of potential targets. We have developed a science sample acquisition resource requirements calculation that utilises differential inverse kinematics methods to yield a high fidelity result, thus improving upon simple 1st order approximations. To test our algorithms a new Planetary Analogue Terrain (PAT) Laboratory has been created that has a terrain region composed of Mars Soil Simulant-D from DLR Germany, and rocks that have been fully characterised in the laboratory. These have been donated by the UK Planetary Analogue Field Study

Meta-tools for software development and knowledge acquisition

NASA Technical Reports Server (NTRS)

Eriksson, Henrik; Musen, Mark A.

1992-01-01

The effectiveness of tools that provide support for software development is highly dependent on the match between the tools and their task. Knowledge-acquisition (KA) tools constitute a class of development tools targeted at knowledge-based systems. Generally, KA tools that are custom-tailored for particular application domains are more effective than are general KA tools that cover a large class of domains. The high cost of custom-tailoring KA tools manually has encouraged researchers to develop meta-tools for KA tools. Current research issues in meta-tools for knowledge acquisition are the specification styles, or meta-views, for target KA tools used, and the relationships between the specification entered in the meta-tool and other specifications for the target program under development. We examine different types of meta-views and meta-tools. Our current project is to provide meta-tools that produce KA tools from multiple specification sources--for instance, from a task analysis of the target application.

Acquisition of speech rhythm in first language.

PubMed

Polyanskaya, Leona; Ordin, Mikhail

2015-09-01

Analysis of English rhythm in speech produced by children and adults revealed that speech rhythm becomes increasingly more stress-timed as language acquisition progresses. Children reach the adult-like target by 11 to 12 years. The employed speech elicitation paradigm ensured that the sentences produced by adults and children at different ages were comparable in terms of lexical content, segmental composition, and phonotactic complexity. Detected differences between child and adult rhythm and between rhythm in child speech at various ages cannot be attributed to acquisition of phonotactic language features or vocabulary, and indicate the development of language-specific phonetic timing in the course of acquisition.

Reflector automatic acquisition and pointing based on auto-collimation theodolite.

PubMed

Luo, Jun; Wang, Zhiqian; Wen, Zhuoman; Li, Mingzhu; Liu, Shaojin; Shen, Chengwu

2018-01-01

An auto-collimation theodolite (ACT) for reflector automatic acquisition and pointing is designed based on the principle of autocollimators and theodolites. First, the principle of auto-collimation and theodolites is reviewed, and then the coaxial ACT structure is developed. Subsequently, the acquisition and pointing strategies for reflector measurements are presented, which first quickly acquires the target over a wide range and then points the laser spot to the charge coupled device zero position. Finally, experiments are conducted to verify the acquisition and pointing performance, including the calibration of the ACT, the comparison of the acquisition mode and pointing mode, and the accuracy measurement in horizontal and vertical directions. In both directions, a measurement accuracy of ±3″ is achieved. The presented ACT is suitable for automatic pointing and monitoring the reflector over a small scanning area and can be used in a wide range of applications such as bridge structure monitoring and cooperative target aiming.

Reflector automatic acquisition and pointing based on auto-collimation theodolite

NASA Astrophysics Data System (ADS)

Luo, Jun; Wang, Zhiqian; Wen, Zhuoman; Li, Mingzhu; Liu, Shaojin; Shen, Chengwu

2018-01-01

An auto-collimation theodolite (ACT) for reflector automatic acquisition and pointing is designed based on the principle of autocollimators and theodolites. First, the principle of auto-collimation and theodolites is reviewed, and then the coaxial ACT structure is developed. Subsequently, the acquisition and pointing strategies for reflector measurements are presented, which first quickly acquires the target over a wide range and then points the laser spot to the charge coupled device zero position. Finally, experiments are conducted to verify the acquisition and pointing performance, including the calibration of the ACT, the comparison of the acquisition mode and pointing mode, and the accuracy measurement in horizontal and vertical directions. In both directions, a measurement accuracy of ±3″ is achieved. The presented ACT is suitable for automatic pointing and monitoring the reflector over a small scanning area and can be used in a wide range of applications such as bridge structure monitoring and cooperative target aiming.

A comparison of foveated acquisition and tracking performance relative to uniform resolution approaches

NASA Astrophysics Data System (ADS)

Dubuque, Shaun; Coffman, Thayne; McCarley, Paul; Bovik, A. C.; Thomas, C. William

2009-05-01

Foveated imaging has been explored for compression and tele-presence, but gaps exist in the study of foveated imaging applied to acquisition and tracking systems. Results are presented from two sets of experiments comparing simple foveated and uniform resolution targeting (acquisition and tracking) algorithms. The first experiments measure acquisition performance when locating Gabor wavelet targets in noise, with fovea placement driven by a mutual information measure. The foveated approach is shown to have lower detection delay than a notional uniform resolution approach when using video that consumes equivalent bandwidth. The second experiments compare the accuracy of target position estimates from foveated and uniform resolution tracking algorithms. A technique is developed to select foveation parameters that minimize error in Kalman filter state estimates. Foveated tracking is shown to consistently outperform uniform resolution tracking on an abstract multiple target task when using video that consumes equivalent bandwidth. Performance is also compared to uniform resolution processing without bandwidth limitations. In both experiments, superior performance is achieved at a given bandwidth by foveated processing because limited resources are allocated intelligently to maximize operational performance. These findings indicate the potential for operational performance improvements over uniform resolution systems in both acquisition and tracking tasks.

COS LP4 FUV Target Acquisition Enabling and Verification

NASA Astrophysics Data System (ADS)

Penton, Steven V.

2016-10-01

This LP4 program is designed to verify the ability of the LV0058/LV0059 COS FSW to place an isolated point source at the center of the PSA, using FUV dispersed light target acquisition (TA) for COS (LP4-TA-COS). Tests will be performed for all 3 FUV TA modes (ACQ/SEARCH, ACQ/PEAKD, and ACQ/PEAKXD). It is sufficient to test ACQ/SEARCH and ACQ/PEAKD with only one grating, but all three FUV gratings need to be tested for the new (as of LV0054) ACQ/PEAKXD with NUM_POS>1 (also known internally, and in the spt files, as OPMODE=ACQ/PEAKD(XD) at the Fourth Lifetime Position (LP4). This program is modeled after the LP2 and LP3 versions of this program; 12797 and 13636.This program has specific visits to test each portion of the FUV spectroscopic TA process. Visits 01-05 will use the target AV18, while Visit 06 will observe (WD1657+343). Both targets are visible year round. For the LP4 enabling, several improvements to APT, the ground system, and the flight software (FSW) have greatly simplified the enabling process. There are now no non-standard exposures, or special commanding, in this program.Specifically; 1) We now use the LIFETIME-POS = LP4 functionality in APT & FSW to specify the LP. The old procedure of using LIFETIME-POS ="ALTERNATE" has been removed. FUV LPs are now called out by number (e.g., LP4). 2) We will be using the new NUM_POS > 1 PEAKXD algorithm at LP4 due to large geometric distortions (GD) at the "Y" detector positions of LP4. FUVA is particularly affected by GD rendering the old PEAKXD algorithm unable to center a target to the required XD accuracy at LP4. 3) Numerous FSW Patchable constants that were essential for PEAKXD operations at previous LPs are no longer required. These are the WCA-to-PSA offsets and XD plate-scales. Like PEAKD, the NUM_POS > 1 PEAKXD requires no patchable constant updates. At previous LPs, numerous updates to the patchable constants were required, this is not necessary for LP4 TA enabling.Prior to the submission of this

Signatures of Higgs dilaton and critical Higgs inflation

NASA Astrophysics Data System (ADS)

García-Bellido, Juan

2018-01-01

We test the Higgs dilaton inflation model (HDM) using the latest cosmological datasets, including the cosmic microwave background temperature, polarization and lensing data from the Planck satellite (2015), the BICEP and Keck Array experiments, the type Ia supernovae from the JLA catalogue, the baryon acoustic oscillations from CMASS, LOWZ and 6dF, the weak lensing data from the CFHTLenS survey and the matter power spectrum measurements from the latest SDSS data release. We find that the values of all cosmological parameters allowed by the HDM are well within the Planck satellite (2015) constraints. In particular, we determine RSTA20170119IM1"/>, RSTA20170119IM2"/>, RSTA20170119IM3"/>, RSTA20170119IM4"/> and RSTA20170119IM5"/> (at 95.5% c.l.). We also place new stringent constraints on the couplings of the HDM, ξχ<0.00328 and RSTA20170119IM6"/> (at 95.5% c.l.). We find that the HDM is only slightly better than the w0waCDM model, with RSTA20170119IM7"/>. Given that the HDM has two fewer parameters, we find Bayesian evidence favouring the HDM over the w0waCDM model. We also study the critical Higgs inflation model, taking into account the running of both the self-coupling λ(μ) and the non-minimal coupling to gravity ξ(μ). We find peaks in the curvature power spectrum at scales corresponding to the critical value μ that re-enter during the radiation era and collapse to form a broad distribution of clustered primordial black holes, which could constitute today the main

Mergers and acquisitions: a most strategic decision.

PubMed

Laine, Mike; Tyler, David

2007-11-01

Five steps are basic to successfully concluding (or deciding not to conclude) a merger or acquisition: Identify targets. Begin with the end in mind. Choose a transaction team. Perform due diligence. Commit to the deal--or to no deal.

Dynamic Target Acquisition: Empirical Models of Operator Performance.

DTIC Science & Technology

1980-08-01

for 30,000 Ft Initial Slant Range VARIABLES MEAN Signature X Scene Complexity Low Medium High Active Target FLIR 22794 20162 20449 Inactive Target...Interactions for 30,000 Ft Initial Slant Range I Signature X Scene Complexity V * ORDERED MEANS 14867 18076 18079 18315 19105 19643 20162 20449 22794...14867 18076 1 183159 19105* 1 19643 20162* 20449 * 1 22794Signature X Speed I ORDERED MEANS 13429 15226 16604 17344 19033 20586 22641 24033 24491 1

Final Report: Non-Visible, Automated Target Acquisition and Tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziock, Klaus-Peter; Fabris, Lorenzo; Goddard, James K.

The Roadside Tracker (RST) represents a new approach to radiation portal monitors. It uses a combination of gamma-ray and visible-light imaging to localize gamma-ray radiation sources to individual vehicles in free-flowing, multi-lane traffic. Deployed as two trailers that are parked on either side of the roadway (Fig. 1); the RST scans passing traffic with two large gamma-ray imagers, one mounted in each trailer. The system compensates for vehicle motion through the imager’s fields of view by using automated target acquisition and tracking (TAT) software applied to a stream of video images. Once a vehicle has left the field of view,more » the radiation image of that vehicle is analyzed for the presence of a source, and if one is found, an alarm is sounded. The gamma-ray image is presented to the operator together with the video image of the traffic stream when the vehicle was approximately closest to the system (Fig. 2). The offending vehicle is identified with a bounding box to distinguish it from other vehicles that might be present at the same time. The system was developed under a previous grant from the Department of Homeland Security’s (DHS’s) Domestic Nuclear Detection Office (DNDO). This report documents work performed with follow-on funding from DNDO to further advance the development of the RST. Specifically, the primary thrust was to extend the performance envelope of the system by replacing the visible-light video cameras used by the TAT software with sensors that would allow operation at night and during inclement weather. In particular, it was desired to allow operation after dark without requiring external lighting. As part of this work, the system software was also upgraded to allow the use of 64-bit computers, the current generation operating system (OS), software development environment (Windows 7 vs. Windows XP, and current Visual Studio.Net), and improved software version controls (GIT vs. Source Safe.) With the upgraded performance

Dynamic FLIR Target Acquisition. Phase I.

DTIC Science & Technology

1978-08-02

The execution of the experimental plan developed and outlined in this report will make up the bulk of our second year effort. The third year will be...outlined in this report will make up the bulk of our second year effort. The third year will be devoted to further experimentation and analysis of...established. 2.1 TARGET SELECTION In an analysis of the success or failure of past air strike campaigns from WW II through the Six Day War (see Figure 2

Improving Vocabulary Acquisition with Multisensory Instruction

ERIC Educational Resources Information Center

D'Alesio, Rosemary; Scalia, Maureen T.; Zabel, Renee M.

2007-01-01

The purpose of this action research project was to improve student vocabulary acquisition through a multisensory, direct instructional approach. The study involved three teachers and a target population of 73 students in second and seventh grade classrooms. The intervention was implemented from September through December of 2006 and analyzed in…

Analytical performance of the various acquisition modes in Orbitrap MS and MS/MS.

PubMed

Kaufmann, Anton

2018-04-30

Quadrupole Orbitrap instruments (Q Orbitrap) permit high-resolution mass spectrometry (HRMS)-based full scan acquisitions and have a number of acquisition modes where the quadrupole isolates a particular mass range prior to a possible fragmentation and HRMS-based acquisition. Selecting the proper acquisition mode(s) is essential if trace analytes are to be quantified in complex matrix extracts. Depending on the particular requirements, such as sensitivity, selectivity of detection, linear dynamic range, and speed of analysis, different acquisition modes may have to be chosen. This is particularly important in the field of multi-residue analysis (e.g., pesticides or veterinary drugs in food samples) where a large number of analytes within a complex matrix have to be detected and reliably quantified. Meeting the specific detection and quantification performance criteria for every targeted compound may be challenging. It is the aim of this paper to describe the strengths and the limitations of the currently available Q Orbitrap acquisition modes. In addition, the incorporation of targeted acquisitions between full scan experiments is discussed. This approach is intended to integrate compounds that require an additional degree of sensitivity or selectivity into multi-residue methods. This article is protected by copyright. All rights reserved.

Acquisition of Nominal Morphophonological Alternations in Russian

ERIC Educational Resources Information Center

Tomas, Ekaterina; van de Vijver, Ruben; Demuth, Katherine; Petocz, Peter

2017-01-01

Morphophonological alternations can make target-like production of grammatical morphemes challenging due to changes in form depending on the phonological environment. This article explores the acquisition of morphophonological alternations involving the interacting patterns of vowel deletion and stress shift in Russian-speaking children (aged…

Naturalistic acquisition in an early language classroom.

PubMed

Dahl, Anne; Vulchanova, Mila D

2014-01-01

This study investigated whether it is possible to provide naturalistic second language acquisition (SLA) of vocabulary for young learners in a classroom situation without resorting to a classical immersion approach. Participants were 60 first-grade pupils in two Norwegian elementary schools in their first year. The control group followed regular instruction as prescribed by the school curriculum, while the experimental group received increased naturalistic target language input. This entailed extensive use of English by the teacher during English classes, and also during morning meetings and for simple instructions and classroom management throughout the day. Our hypothesis was that it is possible to facilitate naturalistic acquisition through better quality target language exposure within a normal curriculum. The students' English vocabulary knowledge was measured using the Peabody Picture Vocabulary Test, version 4 (PPVT-IV, Dunn and Dunn, 2007a), at the beginning and the end of the first year of school. Findings are that (1) early-start second-language (L2) programs in school do not in themselves guarantee vocabulary development in the first year, (2) a focus on increased exposure to the L2 can lead to a significant increase in receptive vocabulary comprehension in the course of only 8 months, and (3) even with relatively modest input, learners in such an early-start L2 program can display vocabulary acquisition comparable in some respects to that of younger native children matched on vocabulary size. The overall conclusion is that naturalistic vocabulary acquisition is in fact possible in a classroom setting.

Naturalistic acquisition in an early language classroom

PubMed Central

Dahl, Anne; Vulchanova, Mila D.

2014-01-01

This study investigated whether it is possible to provide naturalistic second language acquisition (SLA) of vocabulary for young learners in a classroom situation without resorting to a classical immersion approach. Participants were 60 first-grade pupils in two Norwegian elementary schools in their first year. The control group followed regular instruction as prescribed by the school curriculum, while the experimental group received increased naturalistic target language input. This entailed extensive use of English by the teacher during English classes, and also during morning meetings and for simple instructions and classroom management throughout the day. Our hypothesis was that it is possible to facilitate naturalistic acquisition through better quality target language exposure within a normal curriculum. The students' English vocabulary knowledge was measured using the Peabody Picture Vocabulary Test, version 4 (PPVT-IV, Dunn and Dunn, 2007a), at the beginning and the end of the first year of school. Findings are that (1) early-start second-language (L2) programs in school do not in themselves guarantee vocabulary development in the first year, (2) a focus on increased exposure to the L2 can lead to a significant increase in receptive vocabulary comprehension in the course of only 8 months, and (3) even with relatively modest input, learners in such an early-start L2 program can display vocabulary acquisition comparable in some respects to that of younger native children matched on vocabulary size. The overall conclusion is that naturalistic vocabulary acquisition is in fact possible in a classroom setting. PMID:24860518

Nike Facility Diagnostics and Data Acquisition System

NASA Astrophysics Data System (ADS)

Chan, Yung; Aglitskiy, Yefim; Karasik, Max; Kehne, David; Obenschain, Steve; Oh, Jaechul; Serlin, Victor; Weaver, Jim

2013-10-01

The Nike laser-target facility is a 56-beam krypton fluoride system that can deliver 2 to 3 kJ of laser energy at 248 nm onto targets inside a two meter diameter vacuum chamber. Nike is used to study physics and technology issues related to laser direct-drive ICF fusion, including hydrodynamic and laser-plasma instabilities, material behavior at extreme pressures, and optical and x-ray diagnostics for laser-heated targets. A suite of laser and target diagnostics are fielded on the Nike facility, including high-speed, high-resolution x-ray and visible imaging cameras, spectrometers and photo-detectors. A centrally-controlled, distributed computerized data acquisition system provides robust data management and near real-time analysis feedback capability during target shots. Work supported by DOE/NNSA.

The proper treatment of language acquisition and change in a population setting.

PubMed

Niyogi, Partha; Berwick, Robert C

2009-06-23

Language acquisition maps linguistic experience, primary linguistic data (PLD), onto linguistic knowledge, a grammar. Classically, computational models of language acquisition assume a single target grammar and one PLD source, the central question being whether the target grammar can be acquired from the PLD. However, real-world learners confront populations with variation, i.e., multiple target grammars and PLDs. Removing this idealization has inspired a new class of population-based language acquisition models. This paper contrasts 2 such models. In the first, iterated learning (IL), each learner receives PLD from one target grammar but different learners can have different targets. In the second, social learning (SL), each learner receives PLD from possibly multiple targets, e.g., from 2 parents. We demonstrate that these 2 models have radically different evolutionary consequences. The IL model is dynamically deficient in 2 key respects. First, the IL model admits only linear dynamics and so cannot describe phase transitions, attested rapid changes in languages over time. Second, the IL model cannot properly describe the stability of languages over time. In contrast, the SL model leads to nonlinear dynamics, bifurcations, and possibly multiple equilibria and so suffices to model both the case of stable language populations, mixtures of more than 1 language, as well as rapid language change. The 2 models also make distinct, empirically testable predictions about language change. Using historical data, we show that the SL model more faithfully replicates the dynamics of the evolution of Middle English.

Complexity in language acquisition.

PubMed

Clark, Alexander; Lappin, Shalom

2013-01-01

Learning theory has frequently been applied to language acquisition, but discussion has largely focused on information theoretic problems-in particular on the absence of direct negative evidence. Such arguments typically neglect the probabilistic nature of cognition and learning in general. We argue first that these arguments, and analyses based on them, suffer from a major flaw: they systematically conflate the hypothesis class and the learnable concept class. As a result, they do not allow one to draw significant conclusions about the learner. Second, we claim that the real problem for language learning is the computational complexity of constructing a hypothesis from input data. Studying this problem allows for a more direct approach to the object of study--the language acquisition device-rather than the learnable class of languages, which is epiphenomenal and possibly hard to characterize. The learnability results informed by complexity studies are much more insightful. They strongly suggest that target grammars need to be objective, in the sense that the primitive elements of these grammars are based on objectively definable properties of the language itself. These considerations support the view that language acquisition proceeds primarily through data-driven learning of some form. Copyright © 2013 Cognitive Science Society, Inc.

Generation of and Retraction from Cross-Linguistically Motivated Structures in Bilingual First Language Acquisition.

ERIC Educational Resources Information Center

Dopke, Susanne

2000-01-01

Focuses on unusual developmental structures during the simultaneous acquisition of German and English in early childhood, which were evident parallel to a majority of target structures. Explains the cognitive motivation for unusual acquisition structures as well as the eventual retraction from them. (Author/VWL)

Lingua Franca English, Multilingual Communities, and Language Acquisition

ERIC Educational Resources Information Center

Canagarajah, Suresh

2007-01-01

Firth and Wagner (1997) questioned the dichotomies nonnative versus native speaker, learner versus user, and interlanguage versus target language, which reflect a bias toward innateness, cognition, and form in language acquisition. Research on lingua franca English (LFE) not only affirms this questioning, but reveals what multilingual communities…

Target Acquisition: Human Observer Performance Studies and TARGAC Model Validation

DTIC Science & Technology

1994-06-01

complete Scenario I run were displayed on a monitor. A transparent sheet was attached to the face of the monitor, the approach route was sketched on...track, passed a mark on the monitor face , the target was at a stop-sign location. The IRIG-B time of that instance was noted, and, since the distance of...route right 100- 80- 60 - 40 C.) 20 [- ion, A20 recognitio 0 0 . identification,C.) . 1I . I - - -• , 4) 1000 2000 3000 4000 SP Target G Q Target I0

Defense Acquisition Research Journal. Volume 20, Number 2, Issue 66, July 2013

DTIC Science & Technology

2013-07-01

Wirthlin Air Force Institute of Technology Dr. Roy Wood Defense Acquisition University The Defense Acquisition Research Journal, formerly the Defense...of an Economic Price Adjustment Clause to the Government Scot Arnold, Bruce Harmon, Susan Rose, and John Whitley An Economic Price Adjustment (EPA...Adjustment (EPA) Clauses, Risk, Target Fee Valuing the Cost of an Economic Price Adjustment Clause to the Government Scot Arnold, Bruce Harmon, Susan

Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study.

PubMed

Byrne, Elizabeth H; Anahtar, Melis N; Cohen, Kathleen E; Moodley, Amber; Padavattan, Nikita; Ismail, Nasreen; Bowman, Brittany A; Olson, Gregory S; Mabhula, Amanda; Leslie, Alasdair; Ndung'u, Thumbi; Walker, Bruce D; Ghebremichael, Musie S; Dong, Krista L; Kwon, Douglas S

2016-04-01

The use of injectable progestin-only contraceptives has been associated with increased risk of HIV acquisition in observational studies, but the biological mechanisms of this risk remain poorly understood. We aimed to assess the effects of progestins on HIV acquisition risk and the immune environment in the female genital tract. In this prospective cohort, we enrolled HIV-negative South African women aged 18-23 years who were not pregnant and were living in Umlazi, South Africa from the Females Rising through Education, Support, and Health (FRESH) study. We tested for HIV-1 twice per week to monitor incident infection. Every 3 months, we collected demographic and behavioural data in addition to blood and cervical samples. The study objective was to characterise host immune determinants of HIV acquisition risk, including those associated with injectable progestin-only contraceptive use. Hazard ratios (HRs) were estimated using Cox proportional hazards methods. Between Nov 19, 2012, and May 31, 2015, we characterised 432 HIV-uninfected South African women from the FRESH study. In this cohort, 152 women used injectable progestin-only contraceptives, 43 used other forms of contraception, and 222 women used no method of long-term contraception. Women using injectable progestin-only contraceptives were at substantially higher risk of acquiring HIV (12·06 per 100 person-years, 95% CI 6·41-20·63) than women using no long-term contraception (3·71 per 100 person-years, 1·36-8·07; adjusted hazard ratio [aHR] 2·93, 95% CI 1·09-7·868, p=0·0326). HIV-negative injectable progestin-only contraceptive users had 3·92 times the frequency of cervical HIV target cells (CCR5+ CD4 T cells) compared with women using no long-term contraceptive (p=0·0241). Women using no long-term contraceptive in the luteal phase of the menstrual cycle also had a 3·25 times higher frequency of cervical target cells compared with those in the follicular phase (p=0·0488), suggesting that a

Sparsity based target detection for compressive spectral imagery

NASA Astrophysics Data System (ADS)

Boada, David Alberto; Arguello Fuentes, Henry

2016-09-01

Hyperspectral imagery provides significant information about the spectral characteristics of objects and materials present in a scene. It enables object and feature detection, classification, or identification based on the acquired spectral characteristics. However, it relies on sophisticated acquisition and data processing systems able to acquire, process, store, and transmit hundreds or thousands of image bands from a given area of interest which demands enormous computational resources in terms of storage, computationm, and I/O throughputs. Specialized optical architectures have been developed for the compressed acquisition of spectral images using a reduced set of coded measurements contrary to traditional architectures that need a complete set of measurements of the data cube for image acquisition, dealing with the storage and acquisition limitations. Despite this improvement, if any processing is desired, the image has to be reconstructed by an inverse algorithm in order to be processed, which is also an expensive task. In this paper, a sparsity-based algorithm for target detection in compressed spectral images is presented. Specifically, the target detection model adapts a sparsity-based target detector to work in a compressive domain, modifying the sparse representation basis in the compressive sensing problem by means of over-complete training dictionaries and a wavelet basis representation. Simulations show that the presented method can achieve even better detection results than the state of the art methods.

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis*

PubMed Central

Gillet, Ludovic C.; Navarro, Pedro; Tate, Stephen; Röst, Hannes; Selevsek, Nathalie; Reiter, Lukas; Bonner, Ron; Aebersold, Ruedi

2012-01-01

Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to identify and quantify the peptides generated by the proteolysis of a biological sample. However, with the current methods it remains challenging to rapidly, consistently, reproducibly, accurately, and sensitively detect and quantify large fractions of proteomes across multiple samples. Here we present a new strategy that systematically queries sample sets for the presence and quantity of essentially any protein of interest. It consists of using the information available in fragment ion spectral libraries to mine the complete fragment ion maps generated using a data-independent acquisition method. For this study, the data were acquired on a fast, high resolution quadrupole-quadrupole time-of-flight (TOF) instrument by repeatedly cycling through 32 consecutive 25-Da precursor isolation windows (swaths). This SWATH MS acquisition setup generates, in a single sample injection, time-resolved fragment ion spectra for all the analytes detectable within the 400–1200 m/z precursor range and the user-defined retention time window. We show that suitable combinations of fragment ions extracted from these data sets are sufficiently specific to confidently identify query peptides over a dynamic range of 4 orders of magnitude, even if the precursors of the queried peptides are not detectable in the survey scans. We also show that queried peptides are quantified with a consistency and accuracy comparable with that of selected reaction monitoring, the gold standard proteomic quantification method. Moreover, targeted data extraction enables ad libitum quantification refinement and dynamic extension of protein probing by iterative re-mining of the once-and-forever acquired data sets. This combination of unbiased, broad range precursor ion fragmentation and targeted data extraction alleviates most constraints of present proteomic methods and should be equally applicable to the comprehensive

Target Language Variation and Second-Language Acquisition: Learning English in New York City.

ERIC Educational Resources Information Center

Eisenstein, Miriam R.

1986-01-01

Investigates the role of dialect variation in the acquisition of American English by adult second language learners. The study revealed that dialect differences present problems for learners and cause variable intelligibility and negative learner attitude toward some varieties of English and its speakers. This attitude could negatively affect a…

48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (firm target) contracts. 16.403-1 Section 16.403-1 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor), and...

48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... (firm target) contracts. 16.403-1 Section 16.403-1 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor), and...

Distributed Pheromone-Based Swarming Control of Unmanned Air and Ground Vehicles for RSTA

DTIC Science & Technology

2008-03-20

Forthcoming in Proceedings of SPIE Defense & Security Conference, March 2008, Orlando, FL Distributed Pheromone -Based Swarming Control of Unmanned...describes recent advances in a fully distributed digital pheromone algorithm that has demonstrated its effectiveness in managing the complexity of...onboard digital pheromone responding to the needs of the automatic target recognition algorithms. UAVs and UGVs controlled by the same pheromone algorithm

Intragenomic spread of plastid-targeting presequences in the coccolithophore Emiliania huxleyi.

PubMed

Burki, Fabien; Hirakawa, Yoshihisa; Keeling, Patrick J

2012-09-01

Nucleus-encoded plastid-targeted proteins of photosynthetic organisms are generally equipped with an N-terminal presequence required for crossing the plastid membranes. The acquisition of these presequences played a fundamental role in the establishment of plastids. Here, we report a unique case of two non-homologous proteins possessing completely identical presequences consisting of a bipartite plastid-targeting signal in the coccolithophore Emiliania huxleyi. We further show that this presequence is highly conserved in five additional proteins that did not originally function in plastids, representing de novo plastid acquisitions. These are among the most recent cases of presequence spreading from gene to gene and shed light on important evolutionary processes that have been usually erased by the ancient history of plastid evolution. We propose a mechanism of acquisition involving genomic duplications and gene replacement through non-homologous recombination that may have played a more general role for equipping proteins with targeting information.

Identification of Soldier Behaviors Associated with Search and Target Acquisition (STA)

DTIC Science & Technology

2010-05-01

specifically concentrated on representing Soldier and small unit behavior engaging "non-acquired" targets and "non-standard" entities, such as: muzzle ...Forces Are Targeting (e.g., weapon orientation, bullet impacts) Area Where Fire Coming From (e.g., muzzle Flash) Target Handoff...Surveys Cue Average Sum* Participants Muzzle Flash 7.51 34 Hostile Behaviors 7.35 40 Outgoing Fire 7.22 18 Suspicious Behaviors/Activities 6.91

A Novel Regulator Controls Clostridium difficile Sporulation, Motility and Toxin Production

PubMed Central

Edwards, Adrianne N.; Tamayo, Rita; McBride, Shonna M.

2016-01-01

SUMMARY Clostridium difficile, is an anaerobic pathogen that forms spores which promote survival in the environment and transmission to new hosts. The regulatory pathways by which C. difficile initiates spore formation are poorly understood. We identified two factors with limited similarity to the Rap sporulation proteins of other spore-forming bacteria. In this study, we show that disruption of the gene CD3668 reduces sporulation and increases toxin production and motility. This mutant was more virulent and exhibited increased toxin gene expression in the hamster model of infection. Based on these phenotypes, we have renamed this locus rstA, for regulator of sporulation and toxins. Our data demonstrate that RstA is a bifunctional protein that upregulates sporulation through an unidentified pathway and represses motility and toxin production by influencing sigD transcription. Conserved RstA orthologs are present in other pathogenic and industrial Clostridium species and may represent a key regulatory protein controlling clostridial sporulation. PMID:26915493

A novel regulator controls Clostridium difficile sporulation, motility and toxin production.

PubMed

Edwards, Adrianne N; Tamayo, Rita; McBride, Shonna M

2016-06-01

Clostridium difficile is an anaerobic pathogen that forms spores which promote survival in the environment and transmission to new hosts. The regulatory pathways by which C. difficile initiates spore formation are poorly understood. We identified two factors with limited similarity to the Rap sporulation proteins of other spore-forming bacteria. In this study, we show that disruption of the gene CD3668 reduces sporulation and increases toxin production and motility. This mutant was more virulent and exhibited increased toxin gene expression in the hamster model of infection. Based on these phenotypes, we have renamed this locus rstA, for regulator of sporulation and toxins. Our data demonstrate that RstA is a bifunctional protein that upregulates sporulation through an unidentified pathway and represses motility and toxin production by influencing sigD transcription. Conserved RstA orthologs are present in other pathogenic and industrial Clostridium species and may represent a key regulatory protein controlling clostridial sporulation. © 2016 John Wiley & Sons Ltd.

Early Acquisition of Basic Word Order in Japanese

ERIC Educational Resources Information Center

Sugisaki, Koji

2008-01-01

The acquisition of word order has been one of the central issues in the study of child language. One striking finding from the detailed investigation of various child languages is that from the earliest observable stages, children are highly sensitive to the basic word order of their target language. However, the evidence so far comes mainly from…

Are you paying too much for that acquisition?

PubMed

Eccles, R G; Lanes, K L; Wilson, T C

1999-01-01

Despite 30 years of evidence demonstrating that most acquisitions don't create value for the acquiring company, executives continue to make more deals, and bigger deals, every year. There are plenty of reasons why value isn't created, but many times it's simply because the acquiring company paid too much. It's not, however, that acquirers pay too high a price in an absolute sense. Rather, they pay more than the acquisition is worth to them. What is that optimum price? The authors present a systematic way to arrive at it, involving several distinct concepts of value. In today's market, the purchase price of an acquisition will nearly always be higher than the intrinsic value of the company--the price of its stock before any acquisition intentions are announced. The key is to determine how much of that difference is "synergy value"--the value that will result from improvements made when the companies are combined. This value will accrue to the acquirer's shareholders rather than to the target's shareholders. The more synergy value a particular acquisition can generate, the higher the maximum price an acquirer is justified in paying. Just as important as correctly calculating the synergy value is having the discipline to walk away from a deal when the numbers don't add up. If returns to shareholders from acquisitions are no better in the next ten years than they've been in the past 30, the authors warn, it will be because companies have failed to create systematic corporate governance processes that put their simple lessons into practice.

Merger mania: mergers and acquisitions in the generic drug sector from 1995 to 2016.

PubMed

Gagnon, Marc-André; Volesky, Karena D

2017-08-22

Drug shortages and increasing generic drug prices are associated with low levels of competition. Mergers and acquisitions impact the level of competition. Record merger and acquisition activity was reported for the pharmaceutical sector in 2014/15, yet information on mergers and acquisitions in the generic drug sector are absent from the literature. This information is necessary to understand if and how such mergers and acquisitions can be a factor in drug shortages and increasing prices. Data on completed merger and acquisition deals that had a generic drug company being taken over (i.e. 'target') were extracted from Bloomberg Finance L.P. The number and announced value of deals are presented globally, for the United States, and globally excluding the United States annually from 1995 to 2016 in United States dollars. Generic drug companies comprised 9.3% of the value of all deals with pharmaceutical targets occurring from 1995 to 2016. Globally, in 1995 there were no deals, in 2014 there were 22 deals worth $1.86 billion, in 2015 there were 34 deals totalling $33.56 billion, and in 2016 there were 42 deals worth in excess of $44 billion. This substantial increase was partially attributed to Teva's 2016 acquisition of Allergan's generic drug business. The surge in mergers and acquisitions for 2015/16 was driven by deals in the United States, where they represented 89.7% of the dollar value of deals in those years. The recent blitz in mergers and acquisitions signals that the generic drug industry is undergoing a transformation, especially in the United States. This restructuring can negatively affect the level of competition that might impact prices and shortages for some products, emphasizing the importance of updating regulations and procurement policies.

Sentence Reading and Writing for Second Language Vocabulary Acquisition

ERIC Educational Resources Information Center

Pichette, Francois; de Serres, Linda; Lafontaine, Marc

2012-01-01

This study compares the relative effectiveness of reading and writing sentences for the incidental acquisition of new vocabulary in a second language. It also examines if recall varies according to the concreteness of target words. Participants were 203 French-speaking intermediate and advanced English as second language (ESL) learners, tested for…

Acquisition of Skill Proficiency Over Multiple Sessions of a Novel Rover Simulation

NASA Technical Reports Server (NTRS)

Dean, S. L.; DeDios,Y. E.; MacDougall, H. G.; Moore, S. T.; Wood, S. J.

2011-01-01

Following long-duration exploration transits, adaptive changes in sensorimotor function may impair the crew's ability to safely perform manual control tasks such as operating pressurized rovers. Postflight performance will also be influenced by the level of preflight skill proficiency they have attained. The purpose of this study was to characterize the acquisition of skills in a motion-based rover simulation over multiple sessions, and to investigate the effects of varying the simulation scenarios. METHODS: Twenty healthy subjects were tested in 5 sessions, with 1-3 days between sessions. Each session consisted of a serial presentation of 8 discrete tasks to be completed as quickly and accurately as possible. Each task consisted of 1) perspective-taking, using a map that defined a docking target, 2) navigation toward the target around a Martian outpost, and 3) docking a side hatch of the rover to a visually guided target. The simulator utilized a Stewart-type motion base (CKAS, Australia), single-seat cabin with triple scene projection covering 150 deg horizontal by 50 deg vertical, and joystick controller. Subjects were randomly assigned to a control group (tasks identical in the first 4 sessions) or a varied-practice group. The dependent variables for each task included accuracy toward the target and time to completion. RESULTS: The greatest improvements in time to completion occurred during the docking phase. The varied-practice group showed more improvement in perspective-taking accuracy. Perspective-taking accuracy was also affected by the relative orientation of the rover to the docking target. Skill acquisition was correlated with self-ratings of previous gaming experience. DISCUSSION: Varying task selection and difficulty will optimize the preflight acquisition of skills when performing novel operational tasks. Simulation of operational manual control will provide functionally relevant evidence regarding the impact of sensorimotor adaptation on early

48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (successive targets) contracts. 16.403-2 Section 16.403-2 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (successive targets) contracts. (a) Description. (1) A fixed-price incentive (successive targets) contract specifies the following elements, all of which are negotiated at the outset: (i...

48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... (successive targets) contracts. 16.403-2 Section 16.403-2 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (successive targets) contracts. (a) Description. (1) A fixed-price incentive (successive targets) contract specifies the following elements, all of which are negotiated at the outset: (i...

Liquid Hydrogen Target Experience at SLAC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weisend, J.G.; Boyce, R.; Candia, A.

2005-08-29

Liquid hydrogen targets have played a vital role in the physics program at SLAC for the past 40 years. These targets have ranged from small ''beer can'' targets to the 1.5 m long E158 target that was capable of absorbing up to 800 W without any significant density changes. Successful use of these targets has required the development of thin wall designs, liquid hydrogen pumps, remote positioning and alignment systems, safety systems, control and data acquisition systems, cryogenic cooling circuits and heat exchangers. Detailed operating procedures have been created to ensure safety and operational reliability. This paper surveys the evolutionmore » of liquid hydrogen targets at SLAC and discusses advances in several of the enabling technologies that made these targets possible.« less

48 CFR 216.403-2 - Fixed-price incentive (successive targets) contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (successive targets) contracts. 216.403-2 Section 216.403-2 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-2 Fixed-price incentive (successive targets) contracts. See PGI 216.403-2 for guidance on the use of fixed-price incentive (successive targets) contracts. [71 FR 39007...

48 CFR 216.403-2 - Fixed-price incentive (successive targets) contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... (successive targets) contracts. 216.403-2 Section 216.403-2 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-2 Fixed-price incentive (successive targets) contracts. See PGI 216.403-2 for guidance on the use of fixed-price incentive (successive targets) contracts. [71 FR 39007...

76 FR 44280 - Defense Federal Acquisition Regulation Supplement; Simplified Acquisition Threshold for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

...-AH29 Defense Federal Acquisition Regulation Supplement; Simplified Acquisition Threshold for.... 2302(7) to invoke a simplified acquisition threshold that is two times the amount specified at 41 U.S.C... acquisition threshold is $150,000 as specified in Federal Acquisition Regulation 2.101. DATES: Effective Date...

Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring (MRM) and SWATH MS2 data-independent acquisition

PubMed Central

Zawadzka, Anna M.; Schilling, Birgit; Held, Jason M.; Sahu, Alexandria K.; Cusack, Michael P.; Drake, Penelope M.; Fisher, Susan J.; Gibson, Bradford W.

2015-01-01

Human plasma contains proteins that reflect overall health and represents a rich source of proteins for identifying and understanding disease pathophysiology. However, few studies have investigated changes in plasma phosphoproteins. In addition, little is known about the normal variations in these phosphoproteins, especially with respect to specific sites of modification. To address these questions, we evaluated variability in plasma protein phosphorylation in healthy individuals using multiple reaction monitoring (MRM) and SWATH MS2 data-independent acquisition. First, we developed a discovery workflow for phosphopeptide enrichment from plasma and identified targets for MRM assays. Next, we analyzed plasma from healthy donors using an analytical workflow consisting of MRM and SWATH MS2 that targeted phosphopeptides from 58 and 68 phosphoproteins, respectively. These two methods produced similar results showing low variability in 13 phosphosites from 10 phosphoproteins (CVinter <30%) and high interpersonal variation of 16 phosphosites from 14 phosphoproteins (CVinter >30%). Moreover, these phosphopeptides originate from phosphoproteins involved in cellular processes governing homeostasis, immune response, cell-extracellular matrix interactions, lipid and sugar metabolism, and cell signaling. This limited assessment of technical and biological variability in phosphopeptides generated from plasma phosphoproteins among healthy volunteers constitutes a reference for future studies that target protein phosphorylation as biomarkers. PMID:24853916

Language Acquisition without an Acquisition Device

ERIC Educational Resources Information Center

O'Grady, William

2012-01-01

Most explanatory work on first and second language learning assumes the primacy of the acquisition phenomenon itself, and a good deal of work has been devoted to the search for an "acquisition device" that is specific to humans, and perhaps even to language. I will consider the possibility that this strategy is misguided and that language…

What We Don't Learn in the Classroom: The Acquisition of Sociolinguistic Competence during Study Abroad

ERIC Educational Resources Information Center

Kennedy, Kristen M.

2012-01-01

This study examines the acquisition of target-like patterns of variation by 22 American learners of French during study abroad (SA) in France and correlates such acquisition with the creation of dense, multiplex, exchange-based social networks (Milroy 1980) with native speakers (NSs) during the SA period. In this longitudinal study, naturalistic…

Large scale land acquisitions and REDD+: a synthesis of conflicts and opportunities

NASA Astrophysics Data System (ADS)

Carter, Sarah; Manceur, Ameur M.; Seppelt, Ralf; Hermans-Neumann, Kathleen; Herold, Martin; Verchot, Lou

2017-03-01

Large scale land acquisitions (LSLA), and Reducing Emissions from Deforestation and forest Degradation (REDD+) are both land based phenomena which when occurring in the same area, can compete with each other for land. A quantitative analysis of country characteristics revealed that land available for agriculture, accessibility, and political stability are key explanatory factors for a country being targeted for LSLA. Surprisingly LSLA occur in countries with lower accessibility. Countries with good land availability, poor accessibility and political stability may become future targets if they do not already have LSLA. Countries which high levels of agriculture-driven deforestation and LSLA, should develop interventions which reduce forest loss driven either directly or indirectly by LSLA as part of their REDD+ strategies. Both host country and investor-side policies have been identified which could be used more widely to reduce conflicts between LSLA and REDD+. Findings from this research highlight the need for and can inform the development of national and international policies on land acquisitions including green acquisitions such as REDD+. Land management must be considered with all its objectives—including food security, biodiversity conservation, and climate change mitigation—in a coherent strategy which engages relevant stakeholders. This is not currently occurring and might be a key ingredient to achieve the targets under the Sustainable Development Goals 2 and 15 and 16 (related to food security and sustainable agriculture and the protection of forests) among others.

Robust Depth Image Acquisition Using Modulated Pattern Projection and Probabilistic Graphical Models

PubMed Central

Kravanja, Jaka; Žganec, Mario; Žganec-Gros, Jerneja; Dobrišek, Simon; Štruc, Vitomir

2016-01-01

Depth image acquisition with structured light approaches in outdoor environments is a challenging problem due to external factors, such as ambient sunlight, which commonly affect the acquisition procedure. This paper presents a novel structured light sensor designed specifically for operation in outdoor environments. The sensor exploits a modulated sequence of structured light projected onto the target scene to counteract environmental factors and estimate a spatial distortion map in a robust manner. The correspondence between the projected pattern and the estimated distortion map is then established using a probabilistic framework based on graphical models. Finally, the depth image of the target scene is reconstructed using a number of reference frames recorded during the calibration process. We evaluate the proposed sensor on experimental data in indoor and outdoor environments and present comparative experiments with other existing methods, as well as commercial sensors. PMID:27775570

Acquisition of speech rhythm in a second language by learners with rhythmically different native languages.

PubMed

Ordin, Mikhail; Polyanskaya, Leona

2015-08-01

The development of speech rhythm in second language (L2) acquisition was investigated. Speech rhythm was defined as durational variability that can be captured by the interval-based rhythm metrics. These metrics were used to examine the differences in durational variability between proficiency levels in L2 English spoken by French and German learners. The results reveal that durational variability increased as L2 acquisition progressed in both groups of learners. This indicates that speech rhythm in L2 English develops from more syllable-timed toward more stress-timed patterns irrespective of whether the native language of the learner is rhythmically similar to or different from the target language. Although both groups showed similar development of speech rhythm in L2 acquisition, there were also differences: German learners achieved a degree of durational variability typical of the target language, while French learners exhibited lower variability than native British speakers, even at an advanced proficiency level.

Patient-specific optimisation of administered activity and acquisition times for 18F-FDG PET imaging.

PubMed

Wickham, Fred; McMeekin, Helena; Burniston, Maria; McCool, Daniel; Pencharz, Deborah; Skillen, Annah; Wagner, Thomas

2017-12-01

The purpose of this study is to identify a method for optimising the administered activity and acquisition time for 18 F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes and compositions, while limiting radiation doses to patients and staff. Patients referred for FDG scans had bioimpedance measurements. They were injected with 3 MBq/kg of 18 F up to 370 MBq and scanned on a Siemens Biograph mCT at 3 or 4 min per bed position. Data were rebinned to simulate 2- and 1-min acquisitions. Subjective assessments of image quality made by an experienced physician were compared with objective measurements based on signal-to-noise ratio and noise equivalent counts (NEC). A target objective measure of image quality was identified. The activity and acquisition time required to achieve this were calculated for each subject. Multiple regression analysis was used to identify expressions for the activity and acquisition time required in terms of easily measurable patient characteristics. One hundred and eleven patients were recruited, and subjective and objective assessments of image quality were compared for 321 full and reduced time scans. NEC-per-metre was identified as the objective measure which best correlated with the subjective assessment (Spearman rank correlation coefficient 0.77) and the best discriminator for images with a subjective assessment of "definitely adequate" (area under the ROC curve 0.94). A target of 37 Mcount/m was identified. Expressions were identified in terms of patient sex, height and weight for the activity and acquisition time required to achieve this target. Including measurements of body composition in these expressions was not useful. Using these expressions would reduce the mean activity administered to this patient group by 66 MBq compared to the current protocol. Expressions have been identified for the activity and acquisition times required to achieve consistent image quality in FDG imaging

Parallel Spectral Acquisition with an Ion Cyclotron Resonance Cell Array.

PubMed

Park, Sung-Gun; Anderson, Gordon A; Navare, Arti T; Bruce, James E

2016-01-19

Mass measurement accuracy is a critical analytical figure-of-merit in most areas of mass spectrometry application. However, the time required for acquisition of high-resolution, high mass accuracy data limits many applications and is an aspect under continual pressure for development. Current efforts target implementation of higher electrostatic and magnetic fields because ion oscillatory frequencies increase linearly with field strength. As such, the time required for spectral acquisition of a given resolving power and mass accuracy decreases linearly with increasing fields. Mass spectrometer developments to include multiple high-resolution detectors that can be operated in parallel could further decrease the acquisition time by a factor of n, the number of detectors. Efforts described here resulted in development of an instrument with a set of Fourier transform ion cyclotron resonance (ICR) cells as detectors that constitute the first MS array capable of parallel high-resolution spectral acquisition. ICR cell array systems consisting of three or five cells were constructed with printed circuit boards and installed within a single superconducting magnet and vacuum system. Independent ion populations were injected and trapped within each cell in the array. Upon filling the array, all ions in all cells were simultaneously excited and ICR signals from each cell were independently amplified and recorded in parallel. Presented here are the initial results of successful parallel spectral acquisition, parallel mass spectrometry (MS) and MS/MS measurements, and parallel high-resolution acquisition with the MS array system.

75 FR 51416 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... be used for the acquisition of commercial items, and revised the language to address the conditions... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 202, 212, and 234 [DFARS Case 2008-D011] Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items...

76 FR 71833 - Defense Federal Acquisition Regulation Supplement: Simplified Acquisition Threshold for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

...-AH29 Defense Federal Acquisition Regulation Supplement: Simplified Acquisition Threshold for... statutory authority to invoke a simplified acquisition threshold that is two times the normal amount to...) to invoke a simplified acquisition threshold that is two times the amount specified at 41 U.S.C 134...

TARGET - TASK ANALYSIS REPORT GENERATION TOOL, VERSION 1.0

NASA Technical Reports Server (NTRS)

Ortiz, C. J.

1994-01-01

The Task Analysis Report Generation Tool, TARGET, is a graphical interface tool used to capture procedural knowledge and translate that knowledge into a hierarchical report. TARGET is based on VISTA, a knowledge acquisition tool developed by the Naval Systems Training Center. TARGET assists a programmer and/or task expert organize and understand the steps involved in accomplishing a task. The user can label individual steps in the task through a dialogue-box and get immediate graphical feedback for analysis. TARGET users can decompose tasks into basic action kernels or minimal steps to provide a clear picture of all basic actions needed to accomplish a job. This method allows the user to go back and critically examine the overall flow and makeup of the process. The user can switch between graphics (box flow diagrams) and text (task hierarchy) versions to more easily study the process being documented. As the practice of decomposition continues, tasks and their subtasks can be continually modified to more accurately reflect the user's procedures and rationale. This program is designed to help a programmer document an expert's task thus allowing the programmer to build an expert system which can help others perform the task. Flexibility is a key element of the system design and of the knowledge acquisition session. If the expert is not able to find time to work on the knowledge acquisition process with the program developer, the developer and subject matter expert may work in iterative sessions. TARGET is easy to use and is tailored to accommodate users ranging from the novice to the experienced expert systems builder. TARGET is written in C-language for IBM PC series and compatible computers running MS-DOS and Microsoft Windows version 3.0 or 3.1. No source code is supplied. The executable also requires 2Mb of RAM, a Microsoft compatible mouse, a VGA display and an 80286, 386 or 486 processor machine. The standard distribution medium for TARGET is one 5.25 inch 360K

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.

PubMed

McCallum, Fiona J; Persson, Kristina E M; Fowkes, Freya J I; Reiling, Linda; Mugyenyi, Cleopatra K; Richards, Jack S; Simpson, Julie A; Williams, Thomas N; Gilson, Paul R; Hodder, Anthony N; Sanders, Paul R; Anders, Robin F; Narum, David L; Chitnis, Chetan; Crabb, Brendan S; Marsh, Kevin; Beeson, James G

2017-04-01

Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf) malaria and target merozoites to reduce or prevent blood-stage replication and the development of disease. Merozoites present a complex array of antigens to the immune system, and currently, there is only a partial understanding of the targets of protective antibodies and how responses to different antigens are acquired and boosted. We hypothesized that there would be differences in the rate of acquisition of antibodies to different antigens and how well they are boosted by infection, which impacts the acquisition of immunity. We examined responses to a range of merozoite antigens in 2 different cohorts of children and adults with different age structures and levels of malaria exposure. Overall, antibodies were associated with age, exposure, and active infection, and the repertoire of responses increased with age and active infection. However, rates of antibody acquisition varied between antigens and different regions within an antigen following exposure to malaria, supporting our hypothesis. Antigen-specific responses could be broadly classified into early response types in which antibodies were acquired early in childhood exposure and late response types that appear to require substantially more exposure for the development of substantial levels. We identified antigen-specific responses that were effectively boosted after recent infection, whereas other responses were not. These findings advance our understanding of the acquisition of human immunity to malaria and are relevant to the development of malaria vaccines targeting merozoite antigens and the selection of antigens for use in malaria surveillance. © Society for Leukocyte Biology.

An Acquisition Guide for Executives

EPA Pesticide Factsheets

This guide covers the following subjects; What is Acquisition?, Purpose and Primary Functions of the Agency’s Acquisition System, Key Organizations in Acquisitions, Legal Framework, Key Players in Acquisitions, Acquisition Process, Acquisition Thresholds

33. Perimeter acquisition radar building room #320, perimeter acquisition radar ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. Perimeter acquisition radar building room #320, perimeter acquisition radar operations center (PAROC), contains the tactical command and control group equipment required to control the par site. Showing spacetrack monitor console - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... Energy Policy Act target groups, as used in this provision means— (1) An institution of higher education... Policy Act target entities. 952.226-71 Section 952.226-71 Federal Acquisition Regulations System... Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b), insert...

COS NUV Target Acquisition Monitor

NASA Astrophysics Data System (ADS)

Penton, Steven V.

2017-08-01

Visits PA, BA, & BB of this program verify all ACQ/IMAGE mode co-alignments by bootstrapping from PSA+MIRRORA. The assumption, which should be tested at some point, is that the PSA+MIRRORA WCA-to-PSA FSW offsets are still as accurate in defining the center of the PSA relative to the WCA as there were in SMOV. The details of the observations are given is the observing section.Visit PB was an on-hold contingency visit in case, for whatever reason, visit 2A of 14452, did not execute as planned in the fall of 2017. This program was replaced with a better program for aligning the FGGs so we needed to activate this visit to obtain the PSA/MIRRORA to PSA/MIRRORB ACQ/IMAGE alignment. Visit BA of this program takes back-to-back PSA/MIRRORB & BOA/MIRRORA ACQ/Images and images (with flashes) and also takes G230L, G285M as well as FUV LP3 G130M and G140L spectra to test the WCA-to-PSA offsets.Visit BB of this program takes back-to-back BOA/MIRRORA & BOA/MIRRORB ACQ/Images and images (with flashes) and also takes G225M, G185M, and FUV LP3 G160M spectra to test the WCA-to-PSA offsets. Visit BA of this program bootstraps off VIsit PB to co-align the PSA+MIRRORB ACQ/IMAGE mode to the BOA+MIRRORA. Visit BB of this program follows the style of Visit BA and bootstraps from the BOA+MIRRORA mode to the BOA+MIRRORB TA imaging mode. In all visits, lamp+target images are taken before and after the TA imaging mode that is being co-aligned (the second ACQ/IMAGE of the program.)All visits in this program are single orbit visits. This program is very similar to the NUV portion of the C24 version (14857). This program differs from the Cycle 23 version in that Visit PB (the old Visit 03) has been permanently upgraded from contingency to operational status. NOTE: Beginning with Cycle 25. ALL FUV exposures in this program have been moved to a separate monitoring program. This program will sequentially test the XD accuracy of FUV LP4 spectra. As needed, NUV ACQ/IMAGEs will reset the centering

Microcomputer-Based Acquisitions.

ERIC Educational Resources Information Center

Desmarais, Norman

1986-01-01

This discussion of three automated acquisitions systems--Bib-Base/Acq, The Book Trak Ordering System, and Card Datalog Acquisitions Module--covers searching and updating, editing, acquisitions functions and statistics, purchase orders and order file, budgeting and accounts maintenance, defining parameters, documentation, security, printing, and…

Relevant factors to consider prior to an investor-owned acquisition of a nonprofit healthcare entity.

PubMed

Ault, Kelvin; Childs, Brad; Wainright, Charles F; Young, Marilyn

2011-01-01

The purpose of this article is to explore the factors that affect the negotiations for an acquisition of a nonprofit system by an investor-owned entity. The recent economic downturn, accompanying credit crisis, and healthcare reform legislation will likely encourage and accelerate the pace of merger and acquisition (M&A) transactions between investor-owned entities and nonprofit hospitals. As many nonprofits are smaller, more financially vulnerable, and more limited in their access to capital than their investor-owned counterparts, nonprofits could be prime targets for investor-owned acquirers during the healthcare reform implementation period. In M&A transactions of this type, the investor-owned acquirer typically is motivated to pursue an acquisition when the deal promises an acceptable return on investment and decreased operating costs from economies of scale. Alternatively, the nonprofit target is typically seeking funding for upgrades to facilities and information technology systems as well as a continued commitment to charity care and managed-care contracting leverage. A successful acquisition of a nonprofit hospital by an investor-owned company requires a careful analysis of relevant tax, economic, and strategic factors prior to closing the deal. This article lists the most significant factors to consider in these deals and explains how these factors should influence the purchase price and postacquisition cash flow.

A Mixed-Methods Approach to Investigating First- and Second-Language Incidental Vocabulary Acquisition through the Reading of Fiction

ERIC Educational Resources Information Center

Reynolds, Barry Lee

2015-01-01

Adult English-L1 (n = 20) and English-L2 (n = 32) experimental groups were given a novel containing nonce words to read within two weeks to investigate whether the reading of fiction can induce a state of incidental vocabulary acquisition. After reading, an unexpected meaning recall translation assessment measuring acquisition of 49 target nonce…

Capturing the real value in high-tech acquisitions.

PubMed

Chaudhuri, S; Tabrizi, B

1999-01-01

Eager to stay ahead of fast-changing markets, more and more high-tech companies are going outside for competitive advantage. Last year in the United States alone, there were 5,000 high-tech acquisitions, but many of them yielded disappointing results. The reason, the authors contend, is that most managers have a shortsighted view of strategic acquisitions--they focus on the specific products or market share. That focus might make sense in some industries, where those assets can confer substantial advantages, but in high tech, full-fledged technological capabilities--tied to skilled people--are the key to long-term success. Instead of simply following the "buzz," successful acquires systematically assess their own capability needs. They create product road maps to identify holes in their product line. While the business group determines if it can do the work in-house, the business development office scouts for opportunities to buy it. Once business development locates a candidate, it conducts an expanded due diligence, which goes beyond strategic, financial, and legal checks. Successful acquires are focused on long-term capabilities, so they make sure that the target's products reflect a real expertise. They also look to see if key people would be comfortable in the new environment and if they have incentives to stay on board. The final stage of a successful acquisition focuses on retaining the new people--making sure their transition goes smoothly and their energies stay focused. Acquisitions can cause great uncertainty, and skilled people can always go elsewhere. In short, the authors argue, high-tech acquisitions need a new orientation around people, not products.

77 FR 10665 - General Services Administration Acquisition Regulation; Acquisition-Related Thresholds

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-23

... GENERAL SERVICES ADMINISTRATION 48 CFR Parts 519 and 552 [GSAR Amendment 2012-02; GSAR Case 2011-G502; (Change 54) Docket 2012- 0003, Sequence 1] RIN 3090-AJ24 General Services Administration Acquisition Regulation; Acquisition-Related Thresholds AGENCIES: Office of Acquisition Policy, General...

Validating models of target acquisition performance in the dismounted soldier context

NASA Astrophysics Data System (ADS)

Glaholt, Mackenzie G.; Wong, Rachel K.; Hollands, Justin G.

2018-04-01

The problem of predicting real-world operator performance with digital imaging devices is of great interest within the military and commercial domains. There are several approaches to this problem, including: field trials with imaging devices, laboratory experiments using imagery captured from these devices, and models that predict human performance based on imaging device parameters. The modeling approach is desirable, as both field trials and laboratory experiments are costly and time-consuming. However, the data from these experiments is required for model validation. Here we considered this problem in the context of dismounted soldiering, for which detection and identification of human targets are essential tasks. Human performance data were obtained for two-alternative detection and identification decisions in a laboratory experiment in which photographs of human targets were presented on a computer monitor and the images were digitally magnified to simulate range-to-target. We then compared the predictions of different performance models within the NV-IPM software package: Targeting Task Performance (TTP) metric model and the Johnson model. We also introduced a modification to the TTP metric computation that incorporates an additional correction for target angular size. We examined model predictions using NV-IPM default values for a critical model constant, V50, and we also considered predictions when this value was optimized to fit the behavioral data. When using default values, certain model versions produced a reasonably close fit to the human performance data in the detection task, while for the identification task all models substantially overestimated performance. When using fitted V50 values the models produced improved predictions, though the slopes of the performance functions were still shallow compared to the behavioral data. These findings are discussed in relation to the models' designs and parameters, and the characteristics of the behavioral

High levels of postmigration HIV acquisition within nine European countries.

PubMed

Alvarez-Del Arco, Debora; Fakoya, Ibidun; Thomadakis, Christos; Pantazis, Nikos; Touloumi, Giota; Gennotte, Anne-Francoise; Zuure, Freke; Barros, Henrique; Staehelin, Cornelia; Göpel, Siri; Boesecke, Christoph; Prestileo, Tullio; Volny-Anne, Alain; Burns, Fiona; Del Amo, Julia

2017-09-10

We aimed to estimate the proportion of postmigration HIV acquisition among HIV-positive migrants in Europe. To reach HIV-positive migrants, we designed a cross-sectional study performed in HIV clinics. The study was conducted from July 2013 to July 2015 in 57 clinics (nine European countries), targeting individuals over 18 years diagnosed in the preceding 5 years and born abroad. Electronic questionnaires supplemented with clinical data were completed in any of 15 languages. Postmigration HIV acquisition was estimated through Bayesian approaches combining extensive information on migration and patients' characteristics. CD4 cell counts and HIV-RNA trajectories from seroconversion were estimated by bivariate linear mixed models fitted to natural history data. Postmigration acquisition risk factors were investigated with weighted logistic regression. Of 2009 participants, 46% were MSM and a third originated from sub-Saharan Africa and Latin America & Caribbean, respectively. Median time in host countries was 8 years. Postmigration HIV acquisition was 63% (95% confidence interval: 57-67%); 72% among MSM, 58 and 51% in heterosexual men and women, respectively. Postmigration HIV acquisition was 71% for Latin America and Caribbean migrants and 45% for people from sub-Saharan Africa. Factors associated with postmigration HIV acquisition among heterosexual women and MSM were age at migration, length of stay in host country and HIV diagnosis year and among heterosexual men, length of stay in host country and HIV diagnosis year. A substantial proportion of HIV-positive migrants living in Europe acquired HIV postmigration. This has important implications for European public health policies.

Learning (Not) to Predict: Grammatical Gender Processing in Second Language Acquisition

ERIC Educational Resources Information Center

Hopp, Holger

2016-01-01

In two experiments, this article investigates the predictive processing of gender agreement in adult second language (L2) acquisition. We test (1) whether instruction on lexical gender can lead to target predictive agreement processing and (2) how variability in lexical gender representations moderates L2 gender agreement processing. In a…

Investigating Second Language Acquisition.

ERIC Educational Resources Information Center

Jordens, Peter, Ed.; Lalleman, Josine, Ed.

Essays in second language acquisition include: "The State of the Art in Second Language Acquisition Research" (Josine Lalleman); "Crosslinguistic Influence with Special Reference to the Acquisition of Grammar" (Michael Sharwood Smith); "Second Language Acquisition by Adult Immigrants: A Multiple Case Study of Turkish and…

75 FR 5241 - General Services Administration Acquisition Regulation; Rewrite of Part 512, Acquisition of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-02

... Acquisition Regulation; Rewrite of Part 512, Acquisition of Commercial Items AGENCIES: Office of Acquisition... Administration (GSA) is amending the General Services Administration Acquisition Regulation (GSAR) to update the text addressing the acquisition of commercial items. This rule is a result of the GSAM Rewrite...

77 FR 69720 - Federal Acquisition Regulation; Interagency Acquisitions: Compliance by Nondefense Agencies With...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

... 9000-AM36 Federal Acquisition Regulation; Interagency Acquisitions: Compliance by Nondefense Agencies...D, GSA, and NASA are issuing an interim rule amending the Federal Acquisition Regulation (FAR) to add new requirements specific to the acquisition of supplies and services by nondefense agencies on...

31 CFR 30.14 - Q-14: How does section 111 of EESA operate in connection with an acquisition, merger, or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... recipient (target) is acquired by an entity that is not an affiliate of the target (acquirer) in an acquisition of any form, including a purchase of substantially all of the assets of the target, such that the acquirer after the transaction would have been treated as a TARP recipient if the target had received the...

Extending DART to meet the data acquisition needs of future experiments at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oleynik, G.; Pordes, R.; Barsotti, E.

1995-10-01

The DART project at Fermilab is a major collaboration to develop a data acquisition system for multiple experiments. The initial implementation of DART has concentrated on providing working data acquisition systems for the (now eight) collaborating experiments in the next Fixed Target Run. In this paper we discuss aspects of the architecture of DART and how these will allow it to be extended to meet the expected needs of future experiments at Fermilab. We also discuss some ongoing developments within the Fermilab Computing Division towards these new implementations.

Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies

PubMed Central

Tyrrell, Jean

2016-01-01

Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition has the potential to unveil new avenues for therapeutic intervention to treat both acute and chronic CF infections. Here, we examine the range of strategies utilized by the primary CF pathogens to acquire iron and discuss the different approaches to targeting iron acquisition systems as an antimicrobial strategy. PMID:26643057

48 CFR 952.226-73 - Energy Policy Act target group certification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert the...

48 CFR 952.226-73 - Energy Policy Act target group certification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert the...

48 CFR 952.226-73 - Energy Policy Act target group certification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert the...

48 CFR 952.226-73 - Energy Policy Act target group certification.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Energy Policy Act target... ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert the...

The role of mirror neurons in language acquisition and evolution.

PubMed

Behme, Christina

2014-04-01

I argue that Cook et al.'s attack of the genetic hypothesis of mirror neurons misses its target because the authors miss the point that genetics may specify how neurons may learn, not what they learn. Paying more attention to recent work linking mirror neurons to language acquisition and evolution would strengthen Cook et al.'s arguments against a rigid genetic hypothesis.

Review Article: Recent Publications on Research Methods in Second Language Acquisition

ERIC Educational Resources Information Center

Ionin, Tania

2013-01-01

The central goal of the field of second language acquisition (SLA) is to describe and explain how second language learners acquire the target language. In order to achieve this goal, SLA researchers work with second language data, which can take a variety of forms, including (but not limited to) such commonly used methods as naturalistic…

Nominal and functional task difficulty in skill acquisition: Effects on performance in two tests of transfer.

PubMed

Sanli, Elizabeth A; Lee, Timothy D

2015-06-01

The influence of nominal and functional task difficulty during the acquisition of a motor skill was examined in two tests of transfer of learning. The task involved a ballistic, target-directed, finger action. Nominal task difficulty was defined as the distance of the target from the home position. Functional task difficulty was created by manipulating the progression of target distances during practice. Based on the challenge point framework (Guadagnoli & Lee, 2004), we predicted that practice with a set of targets farther away from the performer would benefit from less functional task difficulty, while practice with a closer set of targets would benefit from more functional task difficulty. In single-task transfer tests, learners who practiced using the high nominal task difficulty targets benefitted in terms of persistence of performance over time. In dual-task transfer tests, groups with an intermediate combined (nominal and functional) task difficulty performed with greater persistence over time on tests of transfer than those who practiced with the highest or lowest combined difficulty. Together these findings suggest that the influences of nominal and functional task difficulty during acquisition are weighted differentially depending upon the transfer test context. The challenge point framework does not accurately capture this complex relationship in its current form. Copyright © 2015 Elsevier B.V. All rights reserved.

The Impact of Topic Interest, L2 Proficiency, and Gender on EFL Incidental Vocabulary Acquisition through Reading

ERIC Educational Resources Information Center

Lee, Sunjung; Pulido, Diana

2017-01-01

This study investigated the impact of topic interest, alongside L2 proficiency and gender, on L2 vocabulary acquisition through reading. A repeated-measures design was used with 135 Korean EFL students. Control variables included topic familiarity, prior target-word knowledge, and target-word difficulty (word length, class, and concreteness).…

26 CFR 1.338-6 - Allocation of ADSP and AGUB among target assets.

Code of Federal Regulations, 2010 CFR

2010-04-01

... allocated among Class II acquisition date assets of target in proportion to the fair market values of such... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Allocation of ADSP and AGUB among target assets... among target assets. (a) Scope—(1) In general. This section prescribes rules for allocating ADSP and...

77 FR 56737 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-61; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

... Administration National Aeronautics and Space Administration 48 CFR Chapter 1 Federal Acquisition Regulations... AND SPACE ADMINISTRATION 48 CFR Chapter 1 [Docket FAR 2012-0080, Sequence 6] Federal Acquisition Regulation; Federal Acquisition Circular 2005-61; Introduction AGENCY: Department of Defense (DoD), General...

76 FR 39231 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-53; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... National Aeronautics and Space Administration 48 CFR Chapter 1 Federal Acquisition Regulation; Final Rules... ADMINISTRATION 48 CFR Chapter 1 [Docket FAR 2011-0076, Sequence 5] Federal Acquisition Regulation; Federal Acquisition Circular 2005-53; Introduction AGENCIES: Department of Defense (DoD), General Services...

77 FR 2653 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 212 and 252 RIN 0750-AH27 Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military-Purpose Nondevelopmental Items (DFARS Case 2011-D034) AGENCY: Defense Acquisition Regulations System...

78 FR 60167 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-70; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

...)(3), contracting officers are encouraged to include the changes in these rules in major modifications.... William Clark, Acting Director, Office of Government-wide Acquisition Policy, Office of Acquisition Policy, Office of Government-wide Policy. Federal Acquisition Circular (FAC) 2005-70 is issued under the...

Cas9 specifies functional viral targets during CRISPR-Cas adaptation.

PubMed

Heler, Robert; Samai, Poulami; Modell, Joshua W; Weiner, Catherine; Goldberg, Gregory W; Bikard, David; Marraffini, Luciano A

2015-03-12

Clustered regularly interspaced short palindromic repeat (CRISPR) loci and their associated (Cas) proteins provide adaptive immunity against viral infection in prokaryotes. Upon infection, short phage sequences known as spacers integrate between CRISPR repeats and are transcribed into small RNA molecules that guide the Cas9 nuclease to the viral targets (protospacers). Streptococcus pyogenes Cas9 cleavage of the viral genome requires the presence of a 5'-NGG-3' protospacer adjacent motif (PAM) sequence immediately downstream of the viral target. It is not known whether and how viral sequences flanked by the correct PAM are chosen as new spacers. Here we show that Cas9 selects functional spacers by recognizing their PAM during spacer acquisition. The replacement of cas9 with alleles that lack the PAM recognition motif or recognize an NGGNG PAM eliminated or changed PAM specificity during spacer acquisition, respectively. Cas9 associates with other proteins of the acquisition machinery (Cas1, Cas2 and Csn2), presumably to provide PAM-specificity to this process. These results establish a new function for Cas9 in the genesis of prokaryotic immunological memory.

48 CFR 952.226-73 - Energy Policy Act target group certification.

Code of Federal Regulations, 2014 CFR

2014-10-01

... is: (1) __ An institution of higher education that meets the requirements of 34 CFR 600.4(a), and has... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Energy Policy Act target....226-73 Energy Policy Act target group certification. As prescribed in 926.7007(d), insert the...

75 FR 39413 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-44; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

... Acquisition Council and the Defense Acquisition Regulations Council in this Federal Acquisition Circular (FAC) 2005-44. A companion document, the Small Entity Compliance Guide (SECG), follows this FAC. The FAC.... Please cite FAC 2005-44 and the FAR case number. Interested parties may also visit our Web site at http...

The Role of Hypercorrection in the Acquisition of L2 Phonemic Contrasts

ERIC Educational Resources Information Center

Eckman, Fred R.; Iverson, Gregory K.; Song, Jae Yung

2013-01-01

This article reports empirical findings from an ongoing investigation into the acquisition of second-language (L2) phonemic contrasts. Specifically, we consider the status and role of the phenomenon of hypercorrection in the various stages through which L2 learners develop and internalize a target language (TL) contrast. We adopt the prevailing…

PECAN: Library Free Peptide Detection for Data-Independent Acquisition Tandem Mass Spectrometry Data

PubMed Central

Ting, Ying S.; Egertson, Jarrett D.; Bollinger, James G.; Searle, Brian C.; Payne, Samuel H.; Noble, William Stafford; MacCoss, Michael J.

2017-01-01

In mass spectrometry-based shogun proteomics, data-independent acquisition (DIA) is an emerging technique for unbiased and reproducible measurement of protein mixtures. Without targeting a specific precursor ion, DIA MS/MS spectra are often highly multiplexed, containing product ions from multiple co-fragmenting precursors. Thus, detecting peptides directly from DIA data is challenging; most DIA data analyses require spectral libraries. Here we present a new library-free, peptide-centric tool PECAN that detects peptides directly from DIA data. PECAN reports evidence of detection based on product ion scoring, enabling detection of low abundance analytes with poor precursor ion signal. We benchmarked PECAN with chromatographic peak picking accuracy and peptide detection capability. We further validated PECAN detection with data-dependent acquisition and targeted analyses. Last, we used PECAN to build a library from DIA data and to query sequence variants. Together, these results show that PECAN detects peptides robustly and accurately from DIA data without using a library. PMID:28783153

High rates of antimicrobial drug resistance gene acquisition after international travel, The Netherlands.

PubMed

von Wintersdorff, Christian J H; Penders, John; Stobberingh, Ellen E; Oude Lashof, Astrid M L; Hoebe, Christian J P A; Savelkoul, Paul H M; Wolffs, Petra F G

2014-04-01

We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p<0.001). The prevalence of quinolone resistance encoding genes qnrB and qnrS increased from 6.6% and 8.2% before travel to 36.9% and 55.7% after travel, respectively (both p<0.001). Travel to Southeast Asia and the Indian subcontinent was associated with the highest acquisition rates of qnrS and both blaCTX-M and qnrS, respectively. Investigation of the associations between the acquisitions of the blaCTX-M and qnr genes showed that acquisition of a blaCTX-M gene was not associated with that of a qnrB (p = 0.305) or qnrS (p = 0.080) gene. These findings support the increasing evidence that travelers contribute to the spread of antimicrobial drug resistance.

High Rates of Antimicrobial Drug Resistance Gene Acquisition after International Travel, the Netherlands

PubMed Central

von Wintersdorff, Christian J.H.; Penders, John; Stobberingh, Ellen E.; Lashof, Astrid M.L. Oude; Hoebe, Christian J.P.A.; Savelkoul, Paul H.M.

2014-01-01

We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p<0.001). The prevalence of quinolone resistance encoding genes qnrB and qnrS increased from 6.6% and 8.2% before travel to 36.9% and 55.7% after travel, respectively (both p<0.001). Travel to Southeast Asia and the Indian subcontinent was associated with the highest acquisition rates of qnrS and both blaCTX-M and qnrS, respectively. Investigation of the associations between the acquisitions of the blaCTX-M and qnr genes showed that acquisition of a blaCTX-M gene was not associated with that of a qnrB (p = 0.305) or qnrS (p = 0.080) gene. These findings support the increasing evidence that travelers contribute to the spread of antimicrobial drug resistance. PMID:24655888

Acquisition of /S/ Clusters in Croatian Speaking Children with Phonological Disorders

ERIC Educational Resources Information Center

Mildner, Vesna; Tomic, Diana

2010-01-01

The authors studied the acquisition of nine #sC clusters in 30 Croatian-speaking phonologically disordered children, aged between 3;8-7;0 years, by analysing their renditions of target words elicited in response to visual stimuli presented on a computer screen. Results did not support the idea that a greater jump in sonority from C1 to C2 would…

Helmet-mounted acoustic array for hostile fire detection and localization in an urban environment

NASA Astrophysics Data System (ADS)

Scanlon, Michael V.

2008-04-01

The detection and localization of hostile weapons firing has been demonstrated successfully with acoustic sensor arrays on unattended ground sensors (UGS), ground-vehicles, and unmanned aerial vehicles (UAVs). Some of the more mature systems have demonstrated significant capabilities and provide direct support to ongoing counter-sniper operations. The Army Research Laboratory (ARL) is conducting research and development for a helmet-mounted system to acoustically detect and localize small arms firing, or other events such as RPG, mortars, and explosions, as well as other non-transient signatures. Since today's soldier is quickly being asked to take on more and more reconnaissance, surveillance, & target acquisition (RSTA) functions, sensor augmentation enables him to become a mobile and networked sensor node on the complex and dynamic battlefield. Having a body-worn threat detection and localization capability for events that pose an immediate danger to the soldiers around him can significantly enhance their survivability and lethality, as well as enable him to provide and use situational awareness clues on the networked battlefield. This paper addresses some of the difficulties encountered by an acoustic system in an urban environment. Complex reverberation, multipath, diffraction, and signature masking by building structures makes this a very harsh environment for robust detection and classification of shockwaves and muzzle blasts. Multifunctional acoustic detection arrays can provide persistent surveillance and enhanced situational awareness for every soldier.

75 FR 48872 - General Services Administration Acquisition Regulation; Rewrite of GSAR Part 541, Acquisition of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-12

... Acquisition Regulation; Rewrite of GSAR Part 541, Acquisition of Utility Services AGENCIES: Office of Acquisition Policy, General Services Administration (GSA). ACTION: Final rule. SUMMARY: The General Services Administration (GSA) is amending the General Services Administration Acquisition Regulation (GSAR) to improve the...

Excessive Acquisition in Hoarding

PubMed Central

Frost, Randy O.; Tolin, David F.; Steketee, Gail; Fitch, Kristin E.; Selbo-Bruns, Alexandra

2009-01-01

Compulsive hoarding (the acquisition of and failure to discard large numbers of possessions) is associated with substantial health risk, impairment, and economic burden. However, little research has examined separate components of this definition, particularly excessive acquisition. The present study examined acquisition in hoarding. Participants, 878 self-identified with hoarding and 665 family informants (not matched to hoarding participants), completed an internet survey. Among hoarding participants who met criteria for clinically significant hoarding, 61% met criteria for a diagnosis of compulsive buying and approximately 85% reported excessive acquisition. Family informants indicated that nearly 95% exhibited excessive acquisition. Those who acquired excessively had more severe hoarding; their hoarding had an earlier onset and resulted in more psychiatric work impairment days; and they experienced more symptoms of obsessive-compulsive disorder, depression, and anxiety. Two forms of excessive acquisition (buying and free things) each contributed independent variance in the prediction of hoarding severity and related symptoms. PMID:19261435

Active imaging system performance model for target acquisition

NASA Astrophysics Data System (ADS)

Espinola, Richard L.; Teaney, Brian; Nguyen, Quang; Jacobs, Eddie L.; Halford, Carl E.; Tofsted, David H.

2007-04-01

The U.S. Army RDECOM CERDEC Night Vision & Electronic Sensors Directorate has developed a laser-range-gated imaging system performance model for the detection, recognition, and identification of vehicle targets. The model is based on the established US Army RDECOM CERDEC NVESD sensor performance models of the human system response through an imaging system. The Java-based model, called NVLRG, accounts for the effect of active illumination, atmospheric attenuation, and turbulence effects relevant to LRG imagers, such as speckle and scintillation, and for the critical sensor and display components. This model can be used to assess the performance of recently proposed active SWIR systems through various trade studies. This paper will describe the NVLRG model in detail, discuss the validation of recent model components, present initial trade study results, and outline plans to validate and calibrate the end-to-end model with field data through human perception testing.

Location of planar targets in three space from monocular images

NASA Technical Reports Server (NTRS)

Cornils, Karin; Goode, Plesent W.

1987-01-01

Many pieces of existing and proposed space hardware that would be targets of interest for a telerobot can be represented as planar or near-planar surfaces. Examples include the biostack modules on the Long Duration Exposure Facility, the panels on Solar Max, large diameter struts, and refueling receptacles. Robust and temporally efficient methods for locating such objects with sufficient accuracy are therefore worth developing. Two techniques that derive the orientation and location of an object from its monocular image are discussed and the results of experiments performed to determine translational and rotational accuracy are presented. Both the quadrangle projection and elastic matching techniques extract three-space information using a minimum of four identifiable target points and the principles of the perspective transformation. The selected points must describe a convex polygon whose geometric characteristics are prespecified in a data base. The rotational and translational accuracy of both techniques was tested at various ranges. This experiment is representative of the sensing requirements involved in a typical telerobot target acquisition task. Both techniques determined target location to an accuracy sufficient for consistent and efficient acquisition by the telerobot.

48 CFR 246.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 246.404 Section 246.404 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE...

48 CFR 246.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 246.404 Section 246.404 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE...

48 CFR 246.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 246.404 Section 246.404 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE...

48 CFR 46.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 46.404 Section 46.404 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance...

48 CFR 46.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 46.404 Section 46.404 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance...

48 CFR 46.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 46.404 Section 46.404 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance...

48 CFR 46.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 46.404 Section 46.404 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance...

48 CFR 246.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 246.404 Section 246.404 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE...

48 CFR 246.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 246.404 Section 246.404 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE...

48 CFR 46.404 - Government contract quality assurance for acquisitions at or below the simplified acquisition...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Government contract quality assurance for acquisitions at or below the simplified acquisition threshold. 46.404 Section 46.404 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance...

Development of a data independent acquisition mass spectrometry workflow to enable glycopeptide analysis without predefined glycan compositional knowledge.

PubMed

Lin, Chi-Hung; Krisp, Christoph; Packer, Nicolle H; Molloy, Mark P

2018-02-10

Glycoproteomics investigates glycan moieties in a site specific manner to reveal the functional roles of protein glycosylation. Identification of glycopeptides from data-dependent acquisition (DDA) relies on high quality MS/MS spectra of glycopeptide precursors and often requires manual validation to ensure confident assignments. In this study, we investigated pseudo-MRM (MRM-HR) and data-independent acquisition (DIA) as alternative acquisition strategies for glycopeptide analysis. These approaches allow data acquisition over the full MS/MS scan range allowing data re-analysis post-acquisition, without data re-acquisition. The advantage of MRM-HR over DDA for N-glycopeptide detection was demonstrated from targeted analysis of bovine fetuin where all three N-glycosylation sites were detected, which was not the case with DDA. To overcome the duty cycle limitation of MRM-HR acquisition needed for analysis of complex samples such as plasma we trialed DIA. This allowed development of a targeted DIA method to identify N-glycopeptides without pre-defined knowledge of the glycan composition, thus providing the potential to identify N-glycopeptides with unexpected structures. This workflow was demonstrated by detection of 59 N-glycosylation sites from 41 glycoproteins from a HILIC enriched human plasma tryptic digest. 21 glycoforms of IgG1 glycopeptides were identified including two truncated structures that are rarely reported. We developed a data-independent mass spectrometry workflow to identify specific glycopeptides from complex biological mixtures. The novelty is that this approach does not require glycan composition to be pre-defined, thereby allowing glycopeptides carrying unexpected glycans to be identified. This is demonstrated through the analysis of immunoglobulins in human plasma where we detected two IgG1 glycoforms that are rarely observed. Copyright © 2017 Elsevier B.V. All rights reserved.

Dissociation of polycyclic aromatic hydrocarbons: molecular dynamics studies

NASA Astrophysics Data System (ADS)

Simon, A.; Rapacioli, M.; Rouaut, G.; Trinquier, G.; Gadéa, F. X.

2017-03-01

We present dynamical studies of the dissociation of polycyclic aromatic hydrocarbon (PAH) radical cations in their ground electronic states with significant internal energy. Molecular dynamics simulations are performed, the electronic structure being described on-the-fly at the self-consistent-charge density functional-based tight binding (SCC-DFTB) level of theory. The SCC-DFTB approach is first benchmarked against DFT results. Extensive simulations are achieved for naphthalene RSTA20160195IM1"/>, pyrene RSTA20160195IM2"/> and coronene RSTA20160195IM3"/> at several energies. Such studies enable one to derive significant trends on branching ratios, kinetics, structures and hints on the formation mechanism of the ejected neutral fragments. In particular, dependence of branching ratios on PAH size and energy were retrieved. The losses of H and C2H2 (recognized as the ethyne molecule) were identified as major dissociation channels. The H/C2H2 ratio was found to increase with PAH size and to decrease with energy. For RSTA20160195IM4"/>, which is the most interesting PAH from the astrophysical point of view, the loss of H was found as the quasi-only channel for an internal energy of 30 eV. Overall, in line with experimental trends, decreasing the internal energy or increasing the PAH size will favour the hydrogen loss channels with respect to carbonaceous fragments. This article is part of the themed issue 'Theoretical and computational studies of non-equilibrium and non-statistical dynamics in the gas phase, in the condensed phase and at interfaces'.

76 FR 39243 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-53; Small Entity Compliance Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... ADMINISTRATION 48 CFR Chapter 1 [Docket FAR 2011-0077, Sequence 5] Federal Acquisition Regulation; Federal Acquisition Circular 2005-53; Small Entity Compliance Guide AGENCY: Department of Defense (DoD), General... Federal Acquisition Circular (FAC) 2005-53, which amend the Federal Acquisition Regulation (FAR). An...

Coordinating Council. Seventh Meeting: Acquisitions

NASA Technical Reports Server (NTRS)

1992-01-01

The theme for this NASA Scientific and Technical Information Program Coordinating Council meeting was Acquisitions. In addition to NASA and the NASA Center for AeroSpace Information (CASI) presentations, the report contains fairly lengthy visuals about acquisitions at the Defense Technical Information Center. CASI's acquisitions program and CASI's proactive acquisitions activity were described. There was a presentation on the document evaluation process at CASI. A talk about open literature scope and coverage at the American Institute of Aeronautics and Astronautics was also given. An overview of the STI Program's Acquisitions Experts Committee was given next. Finally acquisitions initiatives of the NASA STI program were presented.

48 CFR 304.7001 - Numbering acquisitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Numbering acquisitions. 304.7001 Section 304.7001 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE MATTERS Acquisition Instrument Identification Numbering System 304.7001 Numbering acquisitions. (a...

48 CFR 3034.004 - Acquisition strategy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Acquisition strategy. 3034.004 Section 3034.004 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND... Acquisition strategy. See (HSAR) 48 CFR 3009.570 for policy applicable to acquisition strategies that consider...

48 CFR 34.004 - Acquisition strategy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition strategy. 34... CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 34.004 Acquisition strategy. The program manager, as specified in agency procedures, shall develop an acquisition strategy tailored to the particular...

Feature Acquisition with Imbalanced Training Data

NASA Technical Reports Server (NTRS)

Thompson, David R.; Wagstaff, Kiri L.; Majid, Walid A.; Jones, Dayton L.

2011-01-01

This work considers cost-sensitive feature acquisition that attempts to classify a candidate datapoint from incomplete information. In this task, an agent acquires features of the datapoint using one or more costly diagnostic tests, and eventually ascribes a classification label. A cost function describes both the penalties for feature acquisition, as well as misclassification errors. A common solution is a Cost Sensitive Decision Tree (CSDT), a branching sequence of tests with features acquired at interior decision points and class assignment at the leaves. CSDT's can incorporate a wide range of diagnostic tests and can reflect arbitrary cost structures. They are particularly useful for online applications due to their low computational overhead. In this innovation, CSDT's are applied to cost-sensitive feature acquisition where the goal is to recognize very rare or unique phenomena in real time. Example applications from this domain include four areas. In stream processing, one seeks unique events in a real time data stream that is too large to store. In fault protection, a system must adapt quickly to react to anticipated errors by triggering repair activities or follow- up diagnostics. With real-time sensor networks, one seeks to classify unique, new events as they occur. With observational sciences, a new generation of instrumentation seeks unique events through online analysis of large observational datasets. This work presents a solution based on transfer learning principles that permits principled CSDT learning while exploiting any prior knowledge of the designer to correct both between-class and withinclass imbalance. Training examples are adaptively reweighted based on a decomposition of the data attributes. The result is a new, nonparametric representation that matches the anticipated attribute distribution for the target events.

Eye-Head Coordination in 31 Space Shuttle Astronauts during Visual Target Acquisition.

PubMed

Reschke, Millard F; Kolev, Ognyan I; Clément, Gilles

2017-10-27

Between 1989 and 1995, NASA evaluated how increases in flight duration of up to 17 days affected the health and performance of Space Shuttle astronauts. Thirty-one Space Shuttle pilots participating in 17 space missions were tested at 3 different times before flight and 3 different times after flight, starting within a few hours of return to Earth. The astronauts moved their head and eyes as quickly as possible from the central fixation point to a specified target located 20°, 30°, or 60° off center. Eye movements were measured with electro-oculography (EOG). Head movements were measured with a triaxial rate sensor system mounted on a headband. The mean time to visually acquire the targets immediately after landing was 7-10% (30-34 ms) slower than mean preflight values, but results returned to baseline after 48 hours. This increase in gaze latency was due to a decrease in velocity and amplitude of both the eye saccade and head movement toward the target. Results were similar after all space missions, regardless of length.

Performance-Based Services Acquisition

DTIC Science & Technology

2011-02-01

47  DoD’s acquisition workforce lacks training and experience in services contracting ... 47  Selecting correct metrics...services more effectively; vii (2) the DoD’s acquisition workforce lacks training and experience in services contracting; (3) selecting correct...private sector; (2) improve the training of government services acquisition personnel; and (3) the USD(AT&L) should incentivize the existing workforce

76 FR 21849 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 213 RIN 0750-AH07 Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card[supreg] and Aircraft Ground Services (DFARS Case 2009-D019) AGENCY: Defense Acquisition Regulations System, Department of...

76 FR 58149 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 213 RIN 0750-AH07 Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card[supreg] and Aircraft Ground Services (DFARS Case 2009-D019) AGENCY: Defense Acquisition Regulations System, Department of...

Frequency Diverse Tracking/Guidance Millimeter Radar Adapted to Target Acquisition,

DTIC Science & Technology

1980-06-01

resolution offered by electro- optical and infrared systems and the adverse environment (fog, battle- field smokes) penetrability which is characteristic of...Reflectors (&1 > 2). 63 ALEXANDER whereAis the transmitted wavelength. It shall also be assumed for this analysis that 2*a4 ’ ( optical region), and that the...and J. L. Brown, "A Preliminary Assessment of Target Classification using Noncoherent Radar Waveforms," US Army Missile Command, Technical Report T-79

Image and Sensor Data Processing for Target Acquisition and Recognition.

DTIC Science & Technology

1980-11-01

technological, cost, size and weight constraints. The critical problem seems to be detecting the target with an acceptable false alarm rate, rather than...for its operation, loss of detail can result from adjacent differing pixels being forced into the same displayed grey-level. This may be detected in...a) Enhanced (b) Fig.1 High contrast scene demonstrating loss of detail in a local area of low contrast Luminance T V Black Peak white wavelength 1

Introduction to Defense Acquisition Management

DTIC Science & Technology

1989-03-01

the system after Most new systems follow the same formatted and its usefullness in the weapon inventory predictable life cycle, and fit the model...natives for system concept development Statement (MNS) setting forth requirements need- -An acquisition strategy is developed to guide ed to meet the...6 BUSINESS, FINANCIAL AND TECHNICAL ASPECTS OF SYSTEMS ACQUISITION Management of the systems acquisition process The acquisition planning phase of the

High dynamic range image acquisition based on multiplex cameras

NASA Astrophysics Data System (ADS)

Zeng, Hairui; Sun, Huayan; Zhang, Tinghua

2018-03-01

High dynamic image is an important technology of photoelectric information acquisition, providing higher dynamic range and more image details, and it can better reflect the real environment, light and color information. Currently, the method of high dynamic range image synthesis based on different exposure image sequences cannot adapt to the dynamic scene. It fails to overcome the effects of moving targets, resulting in the phenomenon of ghost. Therefore, a new high dynamic range image acquisition method based on multiplex cameras system was proposed. Firstly, different exposure images sequences were captured with the camera array, using the method of derivative optical flow based on color gradient to get the deviation between images, and aligned the images. Then, the high dynamic range image fusion weighting function was established by combination of inverse camera response function and deviation between images, and was applied to generated a high dynamic range image. The experiments show that the proposed method can effectively obtain high dynamic images in dynamic scene, and achieves good results.

Grammar and Frequency Effects in the Acquisition of Prosodic Words in European Portuguese

ERIC Educational Resources Information Center

Vigario, Marina; Freitas, Maria Joao; Frota, Sonia

2006-01-01

This paper investigates the acquisition of prosodic words in European Portuguese (EP) through analysis of grammatical and statistical properties of the target language and child speech. The analysis of grammatical properties shows that there are solid cues to the prosodic word (PW) in EP, and the presence of early word-based phonology in child…

Comprehensible Output, From Occurrence to Acquisition: An Agenda for Acquisitional Research.

ERIC Educational Resources Information Center

Shehadeh, Ali

2002-01-01

Proposes a research agenda that makes acquisitional research central to the study of comprehensible output (CO). Looks at the context in which the CO hypothesis was proposed--that of looking beyond comprehensible input as a condition for second language acquisition. (Author/VWL)

48 CFR 2419.804-370 - SBA acceptance under partnership agreements for acquisitions exceeding the simplified acquisition...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false SBA acceptance under partnership agreements for acquisitions exceeding the simplified acquisition threshold. 2419.804-370 Section 2419.804-370 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS...

48 CFR 2419.804-370 - SBA acceptance under partnership agreements for acquisitions exceeding the simplified acquisition...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false SBA acceptance under partnership agreements for acquisitions exceeding the simplified acquisition threshold. 2419.804-370 Section 2419.804-370 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS...

Siderophore-Based Iron Acquisition and Pathogen Control

PubMed Central

Miethke, Marcus; Marahiel, Mohamed A.

2007-01-01

Summary: High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been made in characterizing and understanding mechanisms of siderophore synthesis, secretion, iron scavenging, and siderophore-delivered iron uptake and its release. The regulation of siderophore pathways reveals multilayer networks at the transcriptional and posttranscriptional levels. Due to the key role of many siderophores during virulence, coevolution led to sophisticated strategies of siderophore neutralization by mammals and (re)utilization by bacterial pathogens. Surprisingly, hosts also developed essential siderophore-based iron delivery and cell conversion pathways, which are of interest for diagnostic and therapeutic studies. In the last decades, natural and synthetic compounds have gained attention as potential therapeutics for iron-dependent treatment of infections and further diseases. Promising results for pathogen inhibition were obtained with various siderophore-antibiotic conjugates acting as “Trojan horse” toxins and siderophore pathway inhibitors. In this article, general aspects of siderophore-mediated iron acquisition, recent findings regarding iron-related pathogen-host interactions, and current strategies for iron-dependent pathogen control will be reviewed. Further concepts including the inhibition of novel siderophore pathway targets are discussed. PMID:17804665

Image Acquisition Context

PubMed Central

Bidgood, W. Dean; Bray, Bruce; Brown, Nicolas; Mori, Angelo Rossi; Spackman, Kent A.; Golichowski, Alan; Jones, Robert H.; Korman, Louis; Dove, Brent; Hildebrand, Lloyd; Berg, Michael

1999-01-01

Objective: To support clinically relevant indexing of biomedical images and image-related information based on the attributes of image acquisition procedures and the judgments (observations) expressed by observers in the process of image interpretation. Design: The authors introduce the notion of “image acquisition context,” the set of attributes that describe image acquisition procedures, and present a standards-based strategy for utilizing the attributes of image acquisition context as indexing and retrieval keys for digital image libraries. Methods: The authors' indexing strategy is based on an interdependent message/terminology architecture that combines the Digital Imaging and Communication in Medicine (DICOM) standard, the SNOMED (Systematized Nomenclature of Human and Veterinary Medicine) vocabulary, and the SNOMED DICOM microglossary. The SNOMED DICOM microglossary provides context-dependent mapping of terminology to DICOM data elements. Results: The capability of embedding standard coded descriptors in DICOM image headers and image-interpretation reports improves the potential for selective retrieval of image-related information. This favorably affects information management in digital libraries. PMID:9925229

Data acquisition system

DOEpatents

Shapiro, Stephen L.; Mani, Sudhindra; Atlas, Eugene L.; Cords, Dieter H. W.; Holbrook, Britt

1997-01-01

A data acquisition circuit for a particle detection system that allows for time tagging of particles detected by the system. The particle detection system screens out background noise and discriminate between hits from scattered and unscattered particles. The detection system can also be adapted to detect a wide variety of particle types. The detection system utilizes a particle detection pixel array, each pixel containing a back-biased PIN diode, and a data acquisition pixel array. Each pixel in the particle detection pixel array is in electrical contact with a pixel in the data acquisition pixel array. In response to a particle hit, the affected PIN diodes generate a current, which is detected by the corresponding data acquisition pixels. This current is integrated to produce a voltage across a capacitor, the voltage being related to the amount of energy deposited in the pixel by the particle. The current is also used to trigger a read of the pixel hit by the particle.

[First language acquisition research and theories of language acquisition].

PubMed

Miller, S; Jungheim, M; Ptok, M

2014-04-01

In principle, a child can seemingly easily acquire any given language. First language acquisition follows a certain pattern which to some extent is found to be language independent. Since time immemorial, it has been of interest why children are able to acquire language so easily. Different disciplinary and methodological orientations addressing this question can be identified. A selective literature search in PubMed and Scopus was carried out and relevant monographies were considered. Different, partially overlapping phases can be distinguished in language acquisition research: whereas in ancient times, deprivation experiments were carried out to discover the "original human language", the era of diary studies began in the mid-19th century. From the mid-1920s onwards, behaviouristic paradigms dominated this field of research; interests were focussed on the determination of normal, average language acquisition. The subsequent linguistic period was strongly influenced by the nativist view of Chomsky and the constructivist concepts of Piaget. Speech comprehension, the role of speech input and the relevance of genetic disposition became the centre of attention. The interactionist concept led to a revival of the convergence theory according to Stern. Each of these four major theories--behaviourism, cognitivism, interactionism and nativism--have given valuable and unique impulses, but no single theory is universally accepted to provide an explanation of all aspects of language acquisition. Moreover, it can be critically questioned whether clinicians consciously refer to one of these theories in daily routine work and whether therapies are then based on this concept. It remains to be seen whether or not new theories of grammar, such as the so-called construction grammar (CxG), will eventually change the general concept of language acquisition.

Target detection cycle criteria when using the targeting task performance metric

NASA Astrophysics Data System (ADS)

Hixson, Jonathan G.; Jacobs, Eddie L.; Vollmerhausen, Richard H.

2004-12-01

The US Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate of the US Army (NVESD) has developed a new target acquisition metric to better predict the performance of modern electro-optical imagers. The TTP metric replaces the Johnson criteria. One problem with transitioning to the new model is that the difficulty of searching in a terrain has traditionally been quantified by an "N50." The N50 is the number of Johnson criteria cycles needed for the observer to detect the target half the time, assuming that the observer is not time limited. In order to make use of this empirical data base, a conversion must be found relating Johnson cycles for detection to TTP cycles for detection. This paper describes how that relationship is established. We have found that the relationship between Johnson and TTP is 1:2.7 for the recognition and identification tasks.

Using Machine Learning and Data Analysis to Improve Customer Acquisition and Marketing in Residential Solar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sigrin, Benjamin O

High customer acquisition costs remain a persistent challenge in the U.S. residential solar industry. Effective customer acquisition in the residential solar market is increasingly achieved with the help of data analysis and machine learning, whether that means more targeted advertising, understanding customer motivations, or responding to competitors. New research by the National Renewable Energy Laboratory, Sandia National Laboratories, Vanderbilt University, University of Pennsylvania, and the California Center for Sustainable Energy and funded through the U.S. Department of Energy's Solar Energy Evolution and Diffusion (SEEDS) program demonstrates novel computational methods that can help drive down costs in the residential solar industry.

Evaluation of the Utility of the Theory of Signal Detection for Target Acquisition Studies

DTIC Science & Technology

1979-10-01

also somewhat comparable to what can be expected in the real world when seeking a target. The number of stimuli will be kept at 60 treatments per...the three-dimensional world . This is due to the fact that beyond 300 to 500 feet, binocular cues are lost, and only nonocular cues dominate for depth...to real world .4- viewing (Fowler, 1972) Briefed or Unbriefed Targets. In an operational setting, targets can be briefed or unbriefed. While

Helmet-mounted displays in long-range-target visual acquisition

NASA Astrophysics Data System (ADS)

Wilkins, Donald F.

1999-07-01

Aircrews have always sought a tactical advantage within the visual range (WVR) arena -- usually defined as 'see the opponent first.' Even with radar and interrogation foe/friend (IFF) systems, the pilot who visually acquires his opponent first has a significant advantage. The Helmet Mounted Cueing System (HMCS) equipped with a camera offers an opportunity to correct the problems with the previous approaches. By utilizing real-time image enhancement technique and feeding the image to the pilot on the HMD, the target can be visually acquired well beyond the range provided by the unaided eye. This paper will explore the camera and display requirements for such a system and place those requirements within the context of other requirements, such as weight.

Multimode electromagnetic target discriminator: preliminary data results

NASA Astrophysics Data System (ADS)

Black, Christopher J.; McMichael, Ian T.; Nelson, Carl V.

2004-09-01

This paper describes the Multi-mode Electromagnetic Target Discriminator (METD) sensor and presents preliminary results from recent field experiments. The METD sensor was developed for the US Army RDECOM NVESD by The Johns Hopkins University Applied Physics Laboratory. The METD, based on the technology of the previously developed Electromagnetic Target Discriminator (ETD), is a spatial scanning electromagnetic induction (EMI) sensor that uses both the time-domain (TD) and the frequency-domain (FD) for target detection and classification. Data is collected with a custom data acquisition system and wirelessly transmitted to a base computer. We show that the METD has a high signal-to-noise ratio (SNR), the ability to detect voids created by plastic anti-tank (AT) mines, and is practical for near real-time data processing.

Research on the underwater target imaging based on the streak tube laser lidar

NASA Astrophysics Data System (ADS)

Cui, Zihao; Tian, Zhaoshuo; Zhang, Yanchao; Bi, Zongjie; Yang, Gang; Gu, Erdan

2018-03-01

A high frame rate streak tube imaging lidar (STIL) for real-time 3D imaging of underwater targets is presented in this paper. The system uses 532nm pulse laser as the light source, the maximum repetition rate is 120Hz, and the pulse width is 8ns. LabVIEW platform is used in the system, the system control, synchronous image acquisition, 3D data processing and display are realized through PC. 3D imaging experiment of underwater target is carried out in a flume with attenuation coefficient of 0.2, and the images of different depth and different material targets are obtained, the imaging frame rate is 100Hz, and the maximum detection depth is 31m. For an underwater target with a distance of 22m, the high resolution 3D image real-time acquisition is realized with range resolution of 1cm and space resolution of 0.3cm, the spatial relationship of the targets can be clearly identified by the image. The experimental results show that STIL has a good application prospect in underwater terrain detection, underwater search and rescue, and other fields.

TU-AB-BRA-09: A Novel Method of Generating Ultrafast Volumetric Cine MRI (VC-MRI) Using Prior 4D-MRI and On-Board Phase-Skipped Encoding Acquisition for Radiotherapy Target Localization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, C; Yin, F; Harris, W

Purpose: To develop a technique generating ultrafast on-board VC-MRI using prior 4D-MRI and on-board phase-skipped encoding k-space acquisition for real-time 3D target tracking of liver and lung radiotherapy. Methods: The end-of-expiration (EOE) volume in 4D-MRI acquired during the simulation was selected as the prior volume. 3 major respiratory deformation patterns were extracted through the principal component analysis of the deformation field maps (DFMs) generated between EOE and all other phases. The on-board VC-MRI at each instant was considered as a deformation of the prior volume, and the deformation was modeled as a linear combination of the extracted 3 major deformationmore » patterns. To solve the weighting coefficients of the 3 major patterns, a 2D slice was extracted from VC-MRI volume to match with the 2D on-board sampling data, which was generated by 8-fold phase skipped-encoding k-space acquisition (i.e., sample 1 phase-encoding line out of every 8 lines) to achieve an ultrafast 16–24 volumes/s frame rate. The method was evaluated using XCAT digital phantom to simulate lung cancer patients. The 3D volume of end-ofinhalation (EOI) phase at the treatment day was used as ground-truth onboard VC-MRI with simulated changes in 1) breathing amplitude and 2) breathing amplitude/phase change from the simulation day. A liver cancer patient case was evaluated for in-vivo feasibility demonstration. Results: The comparison between ground truth and estimated on-board VC-MRI shows good agreements. In XCAT study with changed breathing amplitude, the volume-percent-difference(VPD) between ground-truth and estimated tumor volumes at EOI was 6.28% and the Center-of-Mass-Shift(COMS) was 0.82mm; with changed breathing amplitude and phase, the VPD was 8.50% and the COMS was 0.54mm. The study of liver patient case also demonstrated a promising in vivo feasibility of the proposed method Conclusion: Preliminary results suggest the feasibility to estimate ultrafast VC

48 CFR 307.7106 - Acquisition milestones.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Acquisition milestones. 307.7106 Section 307.7106 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES COMPETITION... to track progress of the acquisition. The milestone schedule signatories (see the Requirements and...

48 CFR 307.7106 - Acquisition milestones.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition milestones. 307.7106 Section 307.7106 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES COMPETITION... to track progress of the acquisition. The milestone schedule signatories (see the Requirements and...

23 CFR 710.501 - Early acquisition.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Early acquisition. 710.501 Section 710.501 Highways... REAL ESTATE Property Acquisition Alternatives § 710.501 Early acquisition. (a) Real property... so based on program or project considerations. The State may undertake early acquisition for corridor...

23 CFR 710.501 - Early acquisition.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Early acquisition. 710.501 Section 710.501 Highways... REAL ESTATE Property Acquisition Alternatives § 710.501 Early acquisition. (a) Real property... so based on program or project considerations. The State may undertake early acquisition for corridor...

48 CFR 7.402 - Acquisition methods.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Acquisition methods. 7.402... ACQUISITION PLANNING Equipment Lease or Purchase 7.402 Acquisition methods. (a) Purchase method. (1) Generally, the purchase method is appropriate if the equipment will be used beyond the point in time when...

48 CFR 7.402 - Acquisition methods.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Acquisition methods. 7.402... ACQUISITION PLANNING Equipment Lease or Purchase 7.402 Acquisition methods. (a) Purchase method. (1) Generally, the purchase method is appropriate if the equipment will be used beyond the point in time when...

48 CFR 7.402 - Acquisition methods.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Acquisition methods. 7.402... ACQUISITION PLANNING Equipment Lease or Purchase 7.402 Acquisition methods. (a) Purchase method. (1) Generally, the purchase method is appropriate if the equipment will be used beyond the point in time when...

48 CFR 7.402 - Acquisition methods.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Acquisition methods. 7.402... ACQUISITION PLANNING Equipment Lease or Purchase 7.402 Acquisition methods. (a) Purchase method. (1) Generally, the purchase method is appropriate if the equipment will be used beyond the point in time when...

48 CFR 7.402 - Acquisition methods.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition methods. 7.402... ACQUISITION PLANNING Equipment Lease or Purchase 7.402 Acquisition methods. (a) Purchase method. (1) Generally, the purchase method is appropriate if the equipment will be used beyond the point in time when...

An Attenuated CRISPR-Cas System in Enterococcus faecalis Permits DNA Acquisition

PubMed Central

Hullahalli, Karthik; Rodrigues, Marinelle; Nguyen, Uyen Thy

2018-01-01

ABSTRACT Antibiotic-resistant bacteria are critical public health concerns. Among the prime causative factors for the spread of antibiotic resistance is horizontal gene transfer (HGT). A useful model organism for investigating the relationship between HGT and antibiotic resistance is the opportunistic pathogen Enterococcus faecalis, since the species possesses highly conjugative plasmids that readily disseminate antibiotic resistance genes and virulence factors in nature. Unlike many commensal E. faecalis strains, the genomes of multidrug-resistant (MDR) E. faecalis clinical isolates are enriched for mobile genetic elements (MGEs) and lack clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) genome defense systems. CRISPR-Cas systems cleave foreign DNA in a programmable, sequence-specific manner and are disadvantageous for MGE-derived genome expansion. An unexplored facet of CRISPR biology in E. faecalis is that MGEs that are targeted by native CRISPR-Cas systems can be maintained transiently. Here, we investigate the basis for this “CRISPR tolerance.” We observe that E. faecalis can maintain self-targeting constructs that direct Cas9 to cleave the chromosome, but at a fitness cost. Interestingly, DNA repair genes were not upregulated during self-targeting, but integrated prophages were strongly induced. We determined that low cas9 expression contributes to this transient nonlethality and used this knowledge to develop a robust CRISPR-assisted genome-editing scheme. Our results suggest that E. faecalis has maximized the potential for DNA acquisition by attenuating its CRISPR machinery, thereby facilitating the acquisition of potentially beneficial MGEs that may otherwise be restricted by genome defense. PMID:29717009

77 FR 73515 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-63; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

... Administration National Aeronautics and Space Administration 48 CFR Chapter 1 Federal Acquisition Regulations... AND SPACE ADMINISTRATION 48 CFR Chapter 1 [Docket FAR 2012-0080, Sequence 6] Federal Acquisition... Services Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION: Summary...

First Language Acquisition and Teaching

ERIC Educational Resources Information Center

Cruz-Ferreira, Madalena

2011-01-01

"First language acquisition" commonly means the acquisition of a single language in childhood, regardless of the number of languages in a child's natural environment. Language acquisition is variously viewed as predetermined, wondrous, a source of concern, and as developing through formal processes. "First language teaching" concerns schooling in…

Making Acquisition Measurable

DTIC Science & Technology

2011-04-30

Corporation. All rights reserved End Users Administrator/ Maintainer (A/M) Subject Matter Expert ( SME ) Trainer/ Instructor Manager, Evaluator, Supervisor... CMMI ) - Acquisition (AQ) © 2011 The MITRE Corporation. All rights reserved 13 CMMI -Development Incremental iterative development (planning & execution...objectives Constructing games highlighting particular aspects of proposed CCOD® acquisition, and conducting exercises with Subject Matter Experts ( SMEs

The Influence of Foreign Scripts on the Acquisition of a Second Language Phonological Contrast

ERIC Educational Resources Information Center

Mathieu, Lionel

2016-01-01

Recent studies in the acquisition of a second language (L2) phonology have revealed that orthography can influence the way in which L2 learners come to establish target-like lexical representations (Escudero et al., 2008, 2014; Escudero and Wanrooij, 2010; Showalter, 2012; Showalter and Hayes-Harb, 2013). Most of these studies, however, involve…

25 CFR 700.115 - Preliminary acquisition notice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Acquisition and Disposal of Habitations and/or Improvements § 700.115 Preliminary acquisition notice. As soon as feasible in the acquisition process, the Commission shall issue a preliminary acquisition notice.../her habitations and/or improvements. (b) Explain that such preliminary acquisition notice is not a...

Camouflage target detection via hyperspectral imaging plus information divergence measurement

NASA Astrophysics Data System (ADS)

Chen, Yuheng; Chen, Xinhua; Zhou, Jiankang; Ji, Yiqun; Shen, Weimin

2016-01-01

Target detection is one of most important applications in remote sensing. Nowadays accurate camouflage target distinction is often resorted to spectral imaging technique due to its high-resolution spectral/spatial information acquisition ability as well as plenty of data processing methods. In this paper, hyper-spectral imaging technique together with spectral information divergence measure method is used to solve camouflage target detection problem. A self-developed visual-band hyper-spectral imaging device is adopted to collect data cubes of certain experimental scene before spectral information divergences are worked out so as to discriminate target camouflage and anomaly. Full-band information divergences are measured to evaluate target detection effect visually and quantitatively. Information divergence measurement is proved to be a low-cost and effective tool for target detection task and can be further developed to other target detection applications beyond spectral imaging technique.

Is the Inherent Potential of Maize Roots Efficient for Soil Phosphorus Acquisition?

PubMed Central

Deng, Yan; Chen, Keru; Teng, Wan; Zhan, Ai; Tong, Yiping; Feng, Gu; Cui, Zhenling; Zhang, Fusuo; Chen, Xinping

2014-01-01

Sustainable agriculture requires improved phosphorus (P) management to reduce the overreliance on P fertilization. Despite intensive research of root adaptive mechanisms for improving P acquisition, the inherent potential of roots for efficient P acquisition remains unfulfilled, especially in intensive agriculture, while current P management generally focuses on agronomic and environmental concerns. Here, we investigated how levels of soil P affect the inherent potential of maize (Zea mays L.) roots to obtain P from soil. Responses of root morphology, arbuscular mycorrhizal colonization, and phosphate transporters were characterized and related to agronomic traits in pot and field experiments with soil P supply from deficiency to excess. Critical soil Olsen-P level for maize growth approximated 3.2 mg kg−1, and the threshold indicating a significant environmental risk was about 15 mg kg−1, which represented the lower and upper levels of soil P recommended in current P management. However, most root adaptations involved with P acquisition were triggered when soil Olsen-P was below 10 mg kg−1, indicating a threshold for maximum root inherent potential. Therefore, to maintain efficient inherent potential of roots for P acquisition, we suggest that the target upper level of soil P in intensive agriculture should be reduced from the environmental risk threshold to the point maximizing the inherent potential of roots. PMID:24594677

Is the inherent potential of maize roots efficient for soil phosphorus acquisition?

PubMed

Deng, Yan; Chen, Keru; Teng, Wan; Zhan, Ai; Tong, Yiping; Feng, Gu; Cui, Zhenling; Zhang, Fusuo; Chen, Xinping

2014-01-01

Sustainable agriculture requires improved phosphorus (P) management to reduce the overreliance on P fertilization. Despite intensive research of root adaptive mechanisms for improving P acquisition, the inherent potential of roots for efficient P acquisition remains unfulfilled, especially in intensive agriculture, while current P management generally focuses on agronomic and environmental concerns. Here, we investigated how levels of soil P affect the inherent potential of maize (Zea mays L.) roots to obtain P from soil. Responses of root morphology, arbuscular mycorrhizal colonization, and phosphate transporters were characterized and related to agronomic traits in pot and field experiments with soil P supply from deficiency to excess. Critical soil Olsen-P level for maize growth approximated 3.2 mg kg(-1), and the threshold indicating a significant environmental risk was about 15 mg kg(-1), which represented the lower and upper levels of soil P recommended in current P management. However, most root adaptations involved with P acquisition were triggered when soil Olsen-P was below 10 mg kg(-1), indicating a threshold for maximum root inherent potential. Therefore, to maintain efficient inherent potential of roots for P acquisition, we suggest that the target upper level of soil P in intensive agriculture should be reduced from the environmental risk threshold to the point maximizing the inherent potential of roots.

The Road to Language Learning Is Not Entirely Iconic: Iconicity, Neighborhood Density, and Frequency Facilitate Acquisition of Sign Language.

PubMed

Caselli, Naomi K; Pyers, Jennie E

2017-07-01

Iconic mappings between words and their meanings are far more prevalent than once estimated and seem to support children's acquisition of new words, spoken or signed. We asked whether iconicity's prevalence in sign language overshadows two other factors known to support the acquisition of spoken vocabulary: neighborhood density (the number of lexical items phonologically similar to the target) and lexical frequency. Using mixed-effects logistic regressions, we reanalyzed 58 parental reports of native-signing deaf children's productive acquisition of 332 signs in American Sign Language (ASL; Anderson & Reilly, 2002) and found that iconicity, neighborhood density, and lexical frequency independently facilitated vocabulary acquisition. Despite differences in iconicity and phonological structure between signed and spoken language, signing children, like children learning a spoken language, track statistical information about lexical items and their phonological properties and leverage this information to expand their vocabulary.

48 CFR 908.7101-3 - Direct acquisition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Direct acquisition. 908.7101-3 Section 908.7101-3 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Special Items 908.7101-3 Direct...

2 CFR 200.88 - Simplified acquisition threshold.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Simplified acquisition threshold. 200.88... acquisition threshold. Simplified acquisition threshold means the dollar amount below which a non-Federal... threshold. The simplified acquisition threshold is set by the Federal Acquisition Regulation at 48 CFR...

Unmanned Maritime Systems Incremental Acquisition Approach

DTIC Science & Technology

2016-12-01

We find that current UMS acquisitions are utilizing previous acquisition reforms, but could benefit from additional contractor peer competition and...peer review. Additional cost and schedule benefits could result from contractor competition during build processes in each incremental process. We...acquisitions are utilizing previous acquisition reforms, but could benefit from additional contractor peer competition and peer review. Additional

48 CFR 1.102-3 - Acquisition team.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Acquisition team. 1.102-3... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.102-3 Acquisition team. The purpose of defining the Federal Acquisition Team (Team) in the Guiding Principles is to ensure that participants in the...

48 CFR 1.102-3 - Acquisition team.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Acquisition team. 1.102-3... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.102-3 Acquisition team. The purpose of defining the Federal Acquisition Team (Team) in the Guiding Principles is to ensure that participants in the...

48 CFR 1.102-3 - Acquisition team.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Acquisition team. 1.102-3... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.102-3 Acquisition team. The purpose of defining the Federal Acquisition Team (Team) in the Guiding Principles is to ensure that participants in the...

48 CFR 1.102-3 - Acquisition team.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Acquisition team. 1.102-3... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.102-3 Acquisition team. The purpose of defining the Federal Acquisition Team (Team) in the Guiding Principles is to ensure that participants in the...

48 CFR 1.102-3 - Acquisition team.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition team. 1.102-3... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.102-3 Acquisition team. The purpose of defining the Federal Acquisition Team (Team) in the Guiding Principles is to ensure that participants in the...

Multi-echo acquisition

PubMed Central

Posse, Stefan

2011-01-01

The rapid development of fMRI was paralleled early on by the adaptation of MR spectroscopic imaging (MRSI) methods to quantify water relaxation changes during brain activation. This review describes the evolution of multi-echo acquisition from high-speed MRSI to multi-echo EPI and beyond. It highlights milestones in the development of multi-echo acquisition methods, such as the discovery of considerable gains in fMRI sensitivity when combining echo images, advances in quantification of the BOLD effect using analytical biophysical modeling and interleaved multi-region shimming. The review conveys the insight gained from combining fMRI and MRSI methods and concludes with recent trends in ultra-fast fMRI, which will significantly increase temporal resolution of multi-echo acquisition. PMID:22056458

75 FR 54524 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Life Cycle of Major Defense Acquisition Programs (DFARS Case 2009-D014) AGENCY: Defense Acquisition... competition at both the prime contract and subcontract level of the MDAP throughout its life cycle as a means...

Comparative analysis of sterol acquisition in the oomycetes Saprolegnia parasitica and Phytophthora infestans.

PubMed

Dahlin, Paul; Srivastava, Vaibhav; Ekengren, Sophia; McKee, Lauren S; Bulone, Vincent

2017-01-01

The oomycete class includes pathogens of animals and plants which are responsible for some of the most significant global losses in agriculture and aquaculture. There is a need to replace traditional chemical means of controlling oomycete growth with more targeted approaches, and the inhibition of sterol synthesis is one promising area. To better direct these efforts, we have studied sterol acquisition in two model organisms: the sterol-autotrophic Saprolegnia parasitica, and the sterol-heterotrophic Phytophthora infestans. We first present a comprehensive reconstruction of a likely sterol synthesis pathway for S. parasitica, causative agent of the disease saprolegniasis in fish. This pathway shows multiple potential routes of sterol synthesis, and draws on several avenues of new evidence: bioinformatic mining for genes with sterol-related functions, expression analysis of these genes, and analysis of the sterol profiles in mycelium grown in different media. Additionally, we explore the extent to which P. infestans, which causes the late blight in potato, can modify exogenously provided sterols. We consider whether the two very different approaches to sterol acquisition taken by these pathogens represent any specific survival advantages or potential drug targets.

Comparative analysis of sterol acquisition in the oomycetes Saprolegnia parasitica and Phytophthora infestans

PubMed Central

Dahlin, Paul; Srivastava, Vaibhav; Ekengren, Sophia; McKee, Lauren S.; Bulone, Vincent

2017-01-01

The oomycete class includes pathogens of animals and plants which are responsible for some of the most significant global losses in agriculture and aquaculture. There is a need to replace traditional chemical means of controlling oomycete growth with more targeted approaches, and the inhibition of sterol synthesis is one promising area. To better direct these efforts, we have studied sterol acquisition in two model organisms: the sterol-autotrophic Saprolegnia parasitica, and the sterol-heterotrophic Phytophthora infestans. We first present a comprehensive reconstruction of a likely sterol synthesis pathway for S. parasitica, causative agent of the disease saprolegniasis in fish. This pathway shows multiple potential routes of sterol synthesis, and draws on several avenues of new evidence: bioinformatic mining for genes with sterol-related functions, expression analysis of these genes, and analysis of the sterol profiles in mycelium grown in different media. Additionally, we explore the extent to which P. infestans, which causes the late blight in potato, can modify exogenously provided sterols. We consider whether the two very different approaches to sterol acquisition taken by these pathogens represent any specific survival advantages or potential drug targets. PMID:28152045

48 CFR 52.219-21 - Small Business Size Representation for Targeted Industry Categories Under the Small Business...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Small Business Size Representation for Targeted Industry Categories Under the Small Business Competitiveness Demonstration Program....219-21 Small Business Size Representation for Targeted Industry Categories Under the Small Business...

Depth versus Breadth of Lexical Repertoire: Assessing Their Roles in EFL Students' Incidental Vocabulary Acquisition

ERIC Educational Resources Information Center

Ehsanzadeh, Seyed Jafar

2012-01-01

This study explores the roles of depth and breadth of lexical repertoire in L2 lexical inferencing success and incidental vocabulary acquisition through reading. Students read a graded reader containing 13 pseudo-words and attempted to infer the meanings of underlined target words. The Word Associates Test (WAT, Read, 2004) and the Vocabulary…

Building high-quality assay libraries for targeted analysis of SWATH MS data.

PubMed

Schubert, Olga T; Gillet, Ludovic C; Collins, Ben C; Navarro, Pedro; Rosenberger, George; Wolski, Witold E; Lam, Henry; Amodei, Dario; Mallick, Parag; MacLean, Brendan; Aebersold, Ruedi

2015-03-01

Targeted proteomics by selected/multiple reaction monitoring (S/MRM) or, on a larger scale, by SWATH (sequential window acquisition of all theoretical spectra) MS (mass spectrometry) typically relies on spectral reference libraries for peptide identification. Quality and coverage of these libraries are therefore of crucial importance for the performance of the methods. Here we present a detailed protocol that has been successfully used to build high-quality, extensive reference libraries supporting targeted proteomics by SWATH MS. We describe each step of the process, including data acquisition by discovery proteomics, assertion of peptide-spectrum matches (PSMs), generation of consensus spectra and compilation of MS coordinates that uniquely define each targeted peptide. Crucial steps such as false discovery rate (FDR) control, retention time normalization and handling of post-translationally modified peptides are detailed. Finally, we show how to use the library to extract SWATH data with the open-source software Skyline. The protocol takes 2-3 d to complete, depending on the extent of the library and the computational resources available.

Pushing typists back on the learning curve: contributions of multiple linguistic units in the acquisition of typing skill.

PubMed

Yamaguchi, Motonori; Logan, Gordon D

2014-11-01

The present study investigated the way people acquire and control skilled performance in the context of typewriting. Typing skill was degraded by changing the location of a key (target key) while retaining the locations of other keys to disable an association between the letter and the key. We conducted 4 experiments: Experiment 1 demonstrated that disabling a letter-key association affected not only the execution of the target keystroke but also the planning of other keystrokes for words involving the target key. In Experiments 2-4, typists practiced with a new target location and then transferred to a condition in which they typed the practiced words with the original key location (Experiment 2) or typed new words with the practiced key location (Experiments 3 and 4). Experiment 2 showed that the newly acquired letter-key association interfered with the execution of the original keystroke but not planning. Experiments 3 and 4 demonstrated that acquisition of the new letter-key association depended on multiple levels of linguistic units. Experiment 4 demonstrated that acquisition of the new association depended on sequences both before and after the target keystroke. We discuss implications of the results for 2 prominent approaches to modeling sequential behavior: hierarchical control and recurrent network models. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Automated Validation of Results and Removal of Fragment Ion Interferences in Targeted Analysis of Data-independent Acquisition Mass Spectrometry (MS) using SWATHProphet*

PubMed Central

Keller, Andrew; Bader, Samuel L.; Shteynberg, David; Hood, Leroy; Moritz, Robert L.

2015-01-01

Proteomics by mass spectrometry technology is widely used for identifying and quantifying peptides and proteins. The breadth and sensitivity of peptide detection have been advanced by the advent of data-independent acquisition mass spectrometry. Analysis of such data, however, is challenging due to the complexity of fragment ion spectra that have contributions from multiple co-eluting precursor ions. We present SWATHProphet software that identifies and quantifies peptide fragment ion traces in data-independent acquisition data, provides accurate probabilities to ensure results are correct, and automatically detects and removes contributions to quantitation originating from interfering precursor ions. Integration in the widely used open source Trans-Proteomic Pipeline facilitates subsequent analyses such as combining results of multiple data sets together for improved discrimination using iProphet and inferring sample proteins using ProteinProphet. This novel development should greatly help make data-independent acquisition mass spectrometry accessible to large numbers of users. PMID:25713123

Kilo-sequencing: an ordered strategy for rapid DNA sequence data acquisition.

PubMed Central

Barnes, W M; Bevan, M

1983-01-01

A strategy for rapid DNA sequence acquisition in an ordered, nonrandom manner, while retaining all of the conveniences of the dideoxy method with M13 transducing phage DNA template, is described. Target DNA 3 to 14 kb in size can be stably carried by our M13 vectors. Suitable targets are stretches of DNA which lack an enzyme recognition site which is unique on our cloning vectors and adjacent to the sequencing primer; current sites that are so useful when lacking are Pst, Xba, HindIII, BglII, EcoRI. By an in vitro procedure, we cut RF DNA once randomly and once specifically, to create thousands of deletions which start at the unique restriction site adjacent to the dideoxy sequencing primer and extend various distances across the target DNA. Phage carrying a desired size of deletions, whose DNA as template will give rise to DNA sequence data in a desired location along the target DNA, may be purified by electrophoresis alive on agarose gels. Phage running in the same location on the agarose gel thus conveniently give rise to nucleotide sequence data from the same kilobase of target DNA. Images PMID:6298723

TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection.

PubMed

Namba-Fukuyo, Hiroe; Funata, Sayaka; Matsusaka, Keisuke; Fukuyo, Masaki; Rahmutulla, Bahityar; Mano, Yasunobu; Fukayama, Masashi; Aburatani, Hiroyuki; Kaneda, Atsushi

2016-12-06

Extensive DNA methylation is observed in gastric cancer with Epstein-Barr virus (EBV) infection, and EBV infection is the cause to induce this extensive hypermethylaton phenotype in gastric epithelial cells. However, some 5' regions of genes do not undergo de novo methylation, despite the induction of methylation in surrounding regions, suggesting the existence of a resistance factor against DNA methylation acquisition. We conducted an RNA-seq analysis of gastric epithelial cells with and without EBV infection and found that TET family genes, especially TET2, were repressed by EBV infection at both mRNA and protein levels. TET2 was found to be downregulated by EBV transcripts, e.g. BARF0 and LMP2A, and also by seven human miRNAs targeting TET2, e.g., miR-93 and miR-29a, which were upregulated by EBV infection, and transfection of which into gastric cells repressed TET2. Hydroxymethylation target genes by TET2 were detected by hydroxymethylated DNA immunoprecipitation sequencing (hMeDIP-seq) with and without TET2 overexpression, and overlapped significantly with methylation target genes in EBV-infected cells. When TET2 was knocked down by shRNA, EBV infection induced de novo methylation more severely, including even higher methylation in methylation-acquired promoters or de novo methylation acquisition in methylation-protected promoters, leading to gene repression. TET2 knockdown alone without EBV infection did not induce de novo DNA methylation. These data suggested that TET2 functions as a resistance factor against DNA methylation in gastric epithelial cells and repression of TET2 contributes to DNA methylation acquisition during EBV infection.

Acquisition Strategy Guide,

DTIC Science & Technology

1984-07-01

acquisition stategy for his program. Well informed, educated, and innovative applications and judgments are necessary to structure a successful...program but part of’the Con- operating forces. gress is opposed to it. A case in point is thle MIX missile development. In other instances the Ad...hierarchical format, can be applied to help in The market factors element includes both industrial organizing and structuring an acquisition strategy

Transcriptome-wide Analysis of Exosome Targets

PubMed Central

Schneider, Claudia; Kudla, Grzegorz; Wlotzka, Wiebke; Tuck, Alex; Tollervey, David

2012-01-01

Summary The exosome plays major roles in RNA processing and surveillance but the in vivo target range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA crosslinking (CRAC) to the nucleases (Rrp44, Rrp6), two structural subunits (Rrp41, Csl4) and a cofactor (Trf4) of the yeast exosome. Analysis of wild-type Rrp44 and catalytic mutants showed that both the CUT and SUT classes of non-coding RNA, snoRNAs and, most prominently, pre-tRNAs and other Pol III transcripts are targeted for oligoadenylation and exosome degradation. Unspliced pre-mRNAs were also identified as targets for Rrp44 and Rrp6. CRAC performed using cleavable proteins (split-CRAC) revealed that Rrp44 endonuclease and exonuclease activities cooperate on most substrates. Mapping oligoadenylated reads suggests that the endonuclease activity may release stalled exosome substrates. Rrp6 was preferentially associated with structured targets, which frequently did not associate with the core exosome indicating that substrates follow multiple pathways to the nucleases. PMID:23000172

Mother ship and physical agents collaboration

NASA Astrophysics Data System (ADS)

Young, Stuart H.; Budulas, Peter P.; Emmerman, Philip J.

1999-07-01

This paper discusses ongoing research at the U.S. Army Research Laboratory that investigates the feasibility of developing a collaboration architecture between small physical agents and a mother ship. This incudes the distribution of planning, perception, mobility, processing and communications requirements between the mother ship and the agents. Small physical agents of the future will be virtually everywhere on the battlefield of the 21st century. A mother ship that is coupled to a team of small collaborating physical agents (conducting tasks such as Reconnaissance, Surveillance, and Target Acquisition (RSTA); logistics; sentry; and communications relay) will be used to build a completely effective and mission capable intelligent system. The mother ship must have long-range mobility to deploy the small, highly maneuverable agents that will operate in urban environments and more localized areas, and act as a logistics base for the smaller agents. The mother ship also establishes a robust communications network between the agents and is the primary information disseminating and receiving point to the external world. Because of its global knowledge and processing power, the mother ship does the high-level control and planning for the collaborative physical agents. This high level control and interaction between the mother ship and its agents (including inter agent collaboration) will be software agent architecture based. The mother ship incorporates multi-resolution battlefield visualization and analysis technology, which aids in mission planning and sensor fusion.

ISS Efforts to Fully Utilize its Target Acquisition Capability Serves as an Analog for Future Laser Pointing Communications Systems

NASA Technical Reports Server (NTRS)

Jackson, Dan

2017-01-01

The ISS is an outstanding platform for developing, testing and refining laser communications systems for future exploration. A recent ISS project which improved ISS communications satellite acquisition performance proves the platform’s utility as a laser communications systems testbed.

Root Cortical Aerenchyma Enhances Nitrogen Acquisition from Low-Nitrogen Soils in Maize1[W][OPEN

PubMed Central

Saengwilai, Patompong; Nord, Eric A.; Chimungu, Joseph G.; Brown, Kathleen M.; Lynch, Jonathan Paul

2014-01-01

Suboptimal nitrogen (N) availability is a primary constraint for crop production in developing nations, while in rich nations, intensive N fertilization carries substantial environmental and economic costs. Therefore, understanding root phenes that enhance N acquisition is of considerable importance. Structural-functional modeling predicts that root cortical aerenchyma (RCA) could improve N acquisition in maize (Zea mays). We evaluated the utility of RCA for N acquisition by physiological comparison of maize recombinant inbred lines contrasting in RCA grown under suboptimal and adequate N availability in greenhouse mesocosms and in the field in the United States and South Africa. N stress increased RCA formation by 200% in mesocosms and by 90% to 100% in the field. RCA formation substantially reduced root respiration and root N content. Under low-N conditions, RCA formation increased rooting depth by 15% to 31%, increased leaf N content by 28% to 81%, increased leaf chlorophyll content by 22%, increased leaf CO2 assimilation by 22%, increased vegetative biomass by 31% to 66%, and increased grain yield by 58%. Our results are consistent with the hypothesis that RCA improves plant growth under N-limiting conditions by decreasing root metabolic costs, thereby enhancing soil exploration and N acquisition in deep soil strata. Although potential fitness tradeoffs of RCA formation are poorly understood, increased RCA formation appears be a promising breeding target for enhancing crop N acquisition. PMID:24891611

48 CFR 434.004 - Acquisition strategy.

Code of Federal Regulations, 2010 CFR

2010-10-01

....004 Section 434.004 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL... manager will develop, in coordination with the Acquisition Executive or Major Information Technology... approval of the Acquisition Executive or Major Information Technology Systems Executive, a project control...

Spatial frequency dependence of target signature for infrared performance modeling

NASA Astrophysics Data System (ADS)

Du Bosq, Todd; Olson, Jeffrey

2011-05-01

The standard model used to describe the performance of infrared imagers is the U.S. Army imaging system target acquisition model, based on the targeting task performance metric. The model is characterized by the resolution and sensitivity of the sensor as well as the contrast and task difficulty of the target set. The contrast of the target is defined as a spatial average contrast. The model treats the contrast of the target set as spatially white, or constant, over the bandlimit of the sensor. Previous experiments have shown that this assumption is valid under normal conditions and typical target sets. However, outside of these conditions, the treatment of target signature can become the limiting factor affecting model performance accuracy. This paper examines target signature more carefully. The spatial frequency dependence of the standard U.S. Army RDECOM CERDEC Night Vision 12 and 8 tracked vehicle target sets is described. The results of human perception experiments are modeled and evaluated using both frequency dependent and independent target signature definitions. Finally the function of task difficulty and its relationship to a target set is discussed.

48 CFR 252.211-7000 - Acquisition streamlining.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition streamlining. 252.211-7000 Section 252.211-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text...

Blueprint for Acquisition Reform, Version 3.0

DTIC Science & Technology

2008-07-01

represents a substantial and immediate step forward in establishing the Coast Guard as a model mid-sized federal agency for acquisition processes...Blueprint for Acquisition Reform in the U. S. Coast Guard “The Coast Guard must become the model for mid-sized Federal agency acquisition in process...acquisition (DoD 5000 model >CG Major Systems Acquisition Manual) • Deepwater Program Executive Officer (PEO): System of Systems performance-based

48 CFR 237.7001 - Method of acquisition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Method of acquisition. 237.7001 Section 237.7001 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... contract exists, use DD Form 1155, Order for Supplies or Services, to obtain mortuary services. ...

The roles of word-form frequency and phonological neighbourhood density in the acquisition of Lithuanian noun morphology.

PubMed

Savičiūtė, Eglė; Ambridge, Ben; Pine, Julian M

2018-05-01

Four- and five-year-old children took part in an elicited familiar and novel Lithuanian noun production task to test predictions of input-based accounts of the acquisition of inflectional morphology. Two major findings emerged. First, as predicted by input-based accounts, correct production rates were correlated with the input frequency of the target form, and with the phonological neighbourhood density of the noun. Second, the error patterns were not compatible with the systematic substitution of target forms by either (a) the most frequent form of that noun or (b) a single morphosyntactic default form, as might be predicted by naive versions of a constructivist and generativist account, respectively. Rather, most errors reflected near-miss substitutions of singular for plural, masculine for feminine, or nominative/accusative for a less frequent case. Together, these findings provide support for an input-based approach to morphological acquisition, but are not adequately explained by any single account in its current form.

75 FR 8272 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... Competition Throughout the Life Cycle of Major Defense Acquisition Programs AGENCY: Defense Acquisition... subcontract level of the MDAP throughout its life cycle as a means to improve contractor performance; and (2...) throughout the program life cycle as a means to improve contractor performance; and (ii) Document the...

The Effects of Repetition and L1 Lexicalization on Incidental Vocabulary Acquisition by Iranian EFL Learners

ERIC Educational Resources Information Center

Heidari-Shahreza, Mohammad Ali; Tavakoli, Mansoor

2016-01-01

Based on a prior study by Chen and Truscott, the present study investigated the possible effects of repetition (repeated exposure) and L1 lexicalization on the incidental acquisition and retention of 10 English target words by 90 Persian-speaking EFL learners at an Iranian university. Seven aspects of vocabulary knowledge were measured, including…

Data Acquisition for Modular Biometric Monitoring System

NASA Technical Reports Server (NTRS)

Grodsinsky, Carlos M. (Inventor); Chmiel, Alan J. (Inventor); Humphreys, Bradley T. (Inventor)

2014-01-01

A modular system for acquiring biometric data includes a plurality of data acquisition modules configured to sample biometric data from at least one respective input channel at a data acquisition rate. A representation of the sampled biometric data is stored in memory of each of the plurality of data acquisition modules. A central control system is in communication with each of the plurality of data acquisition modules through a bus. The central control system is configured to collect data asynchronously, via the bus, from the memory of the plurality of data acquisition modules according to a relative fullness of the memory of the plurality of data acquisition modules.

14 CFR 151.73 - Land acquisition.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Land acquisition. 151.73 Section 151.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of...

14 CFR 151.73 - Land acquisition.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Land acquisition. 151.73 Section 151.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of...

14 CFR 151.73 - Land acquisition.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Land acquisition. 151.73 Section 151.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of...

14 CFR 151.73 - Land acquisition.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Land acquisition. 151.73 Section 151.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of...

14 CFR 151.73 - Land acquisition.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Land acquisition. 151.73 Section 151.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Project Programming Standards § 151.73 Land acquisition. (a) The acquisition of...

76 FR 10476 - (General Provisions) Contract Appeals and the Acquisition Regulation: General, Acquisition...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... DEPARTMENT OF ENERGY 10 CFR Part 1023 48 CFR Parts 901, 902, 903, 904, 906, 907, 908, 909, 911, 914, 915, 916, 917, and 952 RIN 1991-AB81 (General Provisions) Contract Appeals and the Acquisition Regulation: General, Acquisition Planning, and Contracting Methods and Contract Types Correction In rule...

7 CFR 1735.20 - Acquisitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... GENERAL POLICIES, TYPES OF LOANS, LOAN REQUIREMENTS-TELECOMMUNICATIONS PROGRAM Loan Purposes and Basic Policies § 1735.20 Acquisitions. (a) RUS finances the acquisition by a borrower of another system, lines...

32 CFR 644.7 - Acquisition lines.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Acquisition lines. 644.7 Section 644.7 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Project Planning Civil Works § 644.7 Acquisition lines. (a) Tentative acquisition lines. As...

LATIST: A Performance Support Tool for Integrating Technologies into Defense Acquisition University Learning Assets

DTIC Science & Technology

2011-07-01

TECHNOLOGIES INTO DEFENSE ACqUISITION UNIVERSITY LEARNING ASSETS Nada Dabbagh, Kevin Clark, Susan Dass , Salim Al Waaili, Sally Byrd, Susan...demographic data, four Likert- scale questions that targeted respondents’ familiarity with ALT, and one Likert- scale question addressing the...use of technology in learning with under- served populations. (E-mail address: kclark6@gmu.edu) Ms. Susan Dass has over 20 years’ experi- ence in

75 FR 43090 - Federal Acquisition Regulation; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-23

... Acquisition Regulation; Correction AGENCY: Department of Defense (DoD), General Services Administration (GSA... Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council are issuing a...

2 CFR 200.2 - Acquisition cost.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Acquisition cost. 200.2 Section 200.2 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.2 Acquisition cost. Acquisition cost...

7 CFR 1735.72 - Acquisition agreements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 11 2014-01-01 2014-01-01 false Acquisition agreements. 1735.72 Section 1735.72... Involving Loan Funds § 1735.72 Acquisition agreements. When borrowers are seeking RUS financing, acquisition agreements between the borrower and the seller must be in form and substance satisfactory to RUS and shall be...

The Impact of One-to-One Technology Programs on Student Acquisition of 21st-Century Skills

ERIC Educational Resources Information Center

McDowell, Joshua A.

2017-01-01

This qualitative phenomenological study was designed to gain an in-depth understanding of the perceptions of secondary public-school teachers of the impact that one-to-one technology programs have on student acquisition of 21st-century skills. 20 certified public school teachers were targeted using a purposeful sampling method, in 4 public school…

An Attenuated CRISPR-Cas System in Enterococcus faecalis Permits DNA Acquisition.

PubMed

Hullahalli, Karthik; Rodrigues, Marinelle; Nguyen, Uyen Thy; Palmer, Kelli

2018-05-01

Antibiotic-resistant bacteria are critical public health concerns. Among the prime causative factors for the spread of antibiotic resistance is horizontal gene transfer (HGT). A useful model organism for investigating the relationship between HGT and antibiotic resistance is the opportunistic pathogen Enterococcus faecalis , since the species possesses highly conjugative plasmids that readily disseminate antibiotic resistance genes and virulence factors in nature. Unlike many commensal E. faecalis strains, the genomes of multidrug-resistant (MDR) E. faecalis clinical isolates are enriched for mobile genetic elements (MGEs) and lack c lustered r egularly i nterspaced s hort p alindromic r epeats (CRISPR) and C RISPR- as sociated protein (Cas) genome defense systems. CRISPR-Cas systems cleave foreign DNA in a programmable, sequence-specific manner and are disadvantageous for MGE-derived genome expansion. An unexplored facet of CRISPR biology in E. faecalis is that MGEs that are targeted by native CRISPR-Cas systems can be maintained transiently. Here, we investigate the basis for this "CRISPR tolerance." We observe that E. faecalis can maintain self-targeting constructs that direct Cas9 to cleave the chromosome, but at a fitness cost. Interestingly, DNA repair genes were not upregulated during self-targeting, but integrated prophages were strongly induced. We determined that low cas9 expression contributes to this transient nonlethality and used this knowledge to develop a robust CRISPR-assisted genome-editing scheme. Our results suggest that E. faecalis has maximized the potential for DNA acquisition by attenuating its CRISPR machinery, thereby facilitating the acquisition of potentially beneficial MGEs that may otherwise be restricted by genome defense. IMPORTANCE CRISPR-Cas has provided a powerful toolkit to manipulate bacteria, resulting in improved genetic manipulations and novel antimicrobials. These powerful applications rely on the premise that CRISPR

Microcomputer data acquisition and control.

PubMed

East, T D

1986-01-01

In medicine and biology there are many tasks that involve routine well defined procedures. These tasks are ideal candidates for computerized data acquisition and control. As the performance of microcomputers rapidly increases and cost continues to go down the temptation to automate the laboratory becomes great. To the novice computer user the choices of hardware and software are overwhelming and sadly most of the computer sales persons are not at all familiar with real-time applications. If you want to bill your patients you have hundreds of packaged systems to choose from; however, if you want to do real-time data acquisition the choices are very limited and confusing. The purpose of this chapter is to provide the novice computer user with the basics needed to set up a real-time data acquisition system with the common microcomputers. This chapter will cover the following issues necessary to establish a real time data acquisition and control system: Analysis of the research problem: Definition of the problem; Description of data and sampling requirements; Cost/benefit analysis. Choice of Microcomputer hardware and software: Choice of microprocessor and bus structure; Choice of operating system; Choice of layered software. Digital Data Acquisition: Parallel Data Transmission; Serial Data Transmission; Hardware and software available. Analog Data Acquisition: Description of amplitude and frequency characteristics of the input signals; Sampling theorem; Specification of the analog to digital converter; Hardware and software available; Interface to the microcomputer. Microcomputer Control: Analog output; Digital output; Closed-Loop Control. Microcomputer data acquisition and control in the 21st Century--What is in the future? High speed digital medical equipment networks; Medical decision making and artificial intelligence.

Issues With Access to Acquisition Data and Information in the Department of Defense: Doing Data Right in Weapon System Acquisition

DTIC Science & Technology

2016-04-30

Defense: Doing Data Right in Weapon System Acquisition Nancy Moore, Senior Management Scientist, RAND Megan McKernan, Defense Research Analyst...Access to Acquisition Data & Information in the Department of Defense: Doing Data Right in Weapon System Acquisition Nancy Moore, Senior Management...With Access to Acquisition Data and Information in the Department of Defense: Doing Data Right in Weapon System Acquisition Nancy Y. Moore—is a

Detection and Tracking of Moving Targets Behind Cluttered Environments Using Compressive Sensing

NASA Astrophysics Data System (ADS)

Dang, Vinh Quang

Detection and tracking of moving targets (target's motion, vibration, etc.) in cluttered environments have been receiving much attention in numerous applications, such as disaster search-and-rescue, law enforcement, urban warfare, etc. One of the popular techniques is the use of stepped frequency continuous wave radar due to its low cost and complexity. However, the stepped frequency radar suffers from long data acquisition time. This dissertation focuses on detection and tracking of moving targets and vibration rates of stationary targets behind cluttered medium such as wall using stepped frequency radar enhanced by compressive sensing. The application of compressive sensing enables the reconstruction of the target space using fewer random frequencies, which decreases the acquisition time. Hardware-accelerated parallelization on GPU is investigated for the Orthogonal Matching Pursuit reconstruction algorithm. For simulation purpose, two hybrid methods have been developed to calculate the scattered fields from the targets through the wall approaching the antenna system, and to convert the incoming fields into voltage signals at terminals of the receive antenna. The first method is developed based on the plane wave spectrum approach for calculating the scattered fields of targets behind the wall. The method uses Fast Multiple Method (FMM) to calculate scattered fields on a particular source plane, decomposes them into plane wave components, and propagates the plane wave spectrum through the wall by integrating wall transmission coefficients before constructing the fields on a desired observation plane. The second method allows one to calculate the complex output voltage at terminals of a receiving antenna which fully takes into account the antenna effects. This method adopts the concept of complex antenna factor in Electromagnetic Compatibility (EMC) community for its calculation.

Private capital investments in health care provision through mergers and acquisitions: from long-term to acute care.

PubMed

Angeli, Federica; Maarse, Hans

2016-10-01

This work aims to test whether different segments of healthcare provision differentially attract private capital and thus offer heterogeneous opportunities for private investors' diversification strategies. Thomson Reuter's SDC Platinum database provided data on 2563 merger and acquisition (M&A) deals targeting healthcare providers in Western Europe between 1990 and 2010. Longitudinal trends of industrial and geographical characteristics of M&As' targets and acquirers are examined. Our analyses highlight: (i) a relative decrease of long-term care facilities as targets of M&As, replaced by an increasing prominence of general hospitals, (ii) a shrinking share of long-term care facilities as targets of financial service organizations' acquisitions, in favor of general hospitals, and (iii) an absolute and relative decrease of long-term care facilities' role as target of cross-border M&As. We explain the decreasing interest of private investors towards long-term care facilities along three lines of reasoning, which take into account the saturation of the long-term care market and the liberalization of acute care provision across Western European countries, regulatory interventions aimed at reducing private ownership to ensure resident outcomes and new cultural developments in favor of small-sized facilities, which strengthen the fragmentation of the sector. These findings advance the literature investigating the effect of private ownership on health outcomes in long-term facilities. Market, policy and cultural forces have emerged over two decades to jointly regulate the presence of privately owned, large-sized long-term care providers, seemingly contributing to safeguard residents' well-being. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Coring Sample Acquisition Tool

NASA Technical Reports Server (NTRS)

Haddad, Nicolas E.; Murray, Saben D.; Walkemeyer, Phillip E.; Badescu, Mircea; Sherrit, Stewart; Bao, Xiaoqi; Kriechbaum, Kristopher L.; Richardson, Megan; Klein, Kerry J.

2012-01-01

A sample acquisition tool (SAT) has been developed that can be used autonomously to sample drill and capture rock cores. The tool is designed to accommodate core transfer using a sample tube to the IMSAH (integrated Mars sample acquisition and handling) SHEC (sample handling, encapsulation, and containerization) without ever touching the pristine core sample in the transfer process.

Concepts for fast acquisition in optical communications systems

NASA Astrophysics Data System (ADS)

Wilkerson, Brandon L.; Giggenbach, Dirk; Epple, Bernhard

2006-09-01

As free-space laser communications systems proliferate due to improved technology and transmission techniques, optical communication networks comprised of ground stations, aircraft, high altitude platforms, and satellites become an attainable goal. An important consideration for optical networks is the ability of optical communication terminals (OCT) to quickly locate one another and align their laser beams to initiate the acquisition sequence. This paper investigates promising low-cost technologies and novel approaches that will facilitate the targeting and acquisition tasks between counter terminals. Specifically, two critical technology areas are investigated: position determination (which includes location and attitude determination) and inter-terminal communications. A feasibility study identified multiple-antenna global navigation satellite system (GNSS) systems and GNSS-aided inertial systems as possible position determination solutions. Personal satellite communication systems (e.g. Iridium or Inmarsat), third generation cellular technology (IMT-2000/UMTS), and a relatively new air traffic surveillance technology called Autonomous Dependent Surveillance-Broadcast (ADS-B) were identified as possible inter-terminal communication solutions. A GNSS-aided inertial system and an ADS-B system were integrated into an OCT to demonstrate their utility in a typical optical communication scenario. Testing showed that these technologies have high potential in future OCTs, although improvements can be made to both to increase tracking accuracy.

Developmental Asynchrony in the Acquisition of Subject Properties in Child L2 English and Spanish

ERIC Educational Resources Information Center

Pladevall-Ballester, Elisabet

2016-01-01

Given that L1A of subject properties in non-null subject languages emerges later than that of null subject languages, this study aims at determining to what extent the same pattern of acquisition is observed in early child L2A in bilingual immersion settings where English and Spanish are both source and target languages. Using an elicited oral…

SPRAT: Spectrograph for the Rapid Acquisition of Transients

NASA Astrophysics Data System (ADS)

Piascik, A. S.; Steele, Iain A.; Bates, Stuart D.; Mottram, Christopher J.; Smith, R. J.; Barnsley, R. M.; Bolton, B.

2014-07-01

We describe the development of a low cost, low resolution (R ~ 350), high throughput, long slit spectrograph covering visible (4000-8000) wavelengths. The spectrograph has been developed for fully robotic operation with the Liverpool Telescope (La Palma). The primary aim is to provide rapid spectral classification of faint (V ˜ 20) transient objects detected by projects such as Gaia, iPTF (intermediate Palomar Transient Factory), LOFAR, and a variety of high energy satellites. The design employs a volume phase holographic (VPH) transmission grating as the dispersive element combined with a prism pair (grism) in a linear optical path. One of two peak spectral sensitivities are selectable by rotating the grism. The VPH and prism combination and entrance slit are deployable, and when removed from the beam allow the collimator/camera pair to re-image the target field onto the detector. This mode of operation provides automatic acquisition of the target onto the slit prior to spectrographic observation through World Coordinate System fitting. The selection and characterisation of optical components to maximise photon throughput is described together with performance predictions.

Native sound category formation in simultaneous bilingual acquisition

NASA Astrophysics Data System (ADS)

Bosch, Laura

2004-05-01

The consequences of early bilingual exposure on the perceptual reorganization processes that occur by the end of the first year of life were analyzed in a series of experiments on the capacity to discriminate vowel and consonant contrasts, comparing monolingual and bilingual infants (Catalan/Spanish) at different age levels. For bilingual infants, the discrimination of target vowel contrasts, which reflect different amount of overlapping and acoustic distance between the two languages of exposure, suggested a U-shaped developmental pattern. A similar trend was observed in the bilingual infants discrimination of a fricative voicing contrast, present in only one of the languages in their environment. The temporary decline in sensitivity found at 8 months for vowel targets and at 12 months for the voicing contrast reveals the specific perceptual processes that bilingual infants develop in order to deal with their complex linguistic input. Data from adult bilingual subjects on a lexical decision task involving these contrasts add to this developmental picture and suggest the existence of a dominant language even in simultaneous bilingual acquisition. [Work supported by JSMF 10001079BMB.

The face of AIDS: Effects of physical attractiveness and target gender on inferred mode of HIV infection.

PubMed

Boehm, L; Wambaugh, M; Riney, T; Kunzelman, C

1996-04-01

We examined the effects of physical attractiveness on the assumed mode of HIV acquisition. 176 students read a description of an HIV-positive target whose photograph was placed above the description. A 2 (target gender) by 2 (attractive or unattractive target) factorial design was used. Unattractive targets were perceived as more likely to have acquired HIV through homosexual relationships. Further, men were perceived as more likely than women to have acquired HIV homosexually. Attractiveness did not bias health-care allocations regarding the infected target.

OPS MCC level B/C formulation requirements: Area targets and space volumes processor

NASA Technical Reports Server (NTRS)

Bishop, M. J., Jr.

1979-01-01

The level B/C mathematical specifications for the area targets and space volumes processor (ATSVP) are described. The processor is designed to compute the acquisition-of-signal (AOS) and loss-of-signal (LOS) times for area targets and space volumes. The characteristics of the area targets and space volumes are given. The mathematical equations necessary to determine whether the spacecraft lies within the area target or space volume are given. These equations provide a detailed model of the target geometry. A semianalytical technique for predicting the AOS and LOS time periods is disucssed. This technique was designed to bound the actual visibility period using a simplified target geometry model and unperturbed orbital motion. Functional overview of the ATSVP is presented and it's detailed logic flow is described.

Automated Acquisition Systems: Keynote Address.

ERIC Educational Resources Information Center

Boss, Richard D.

1980-01-01

The 1980s offer libraries numerous automated acquisitions alternatives, including turnkey systems from circulation system vendors and the acquisition subsystems of the bibliographic utilities. Integration of systems from several sources poses the principal problem. (Author/RAA)

MR 201104: Evaluation of Discrimination Technologies and Classification Results and MR 201157: Demonstration of MetalMapper Static Data Acquisition and Data Analysis

DTIC Science & Technology

2016-09-23

Acquisition and Data Analysis). EMI sensors, MetalMapper, man-portable Time-domain Electromagnetic Multi-sensor Towed Array Detection System (TEMTADS...California Department of Toxic Substances Control EM61 EM61-MK2 EMI electromagnetic induction ESTCP Environmental Security Technology Certification...SOP Standard Operating Procedure v TEMTADS Time-domain Electromagnetic Multi-sensor Towed Array Detection System man-portable 2x2 TOI target(s

Cooperative Robots to Observe Moving Targets: Review.

PubMed

Khan, Asif; Rinner, Bernhard; Cavallaro, Andrea

2018-01-01

The deployment of multiple robots for achieving a common goal helps to improve the performance, efficiency, and/or robustness in a variety of tasks. In particular, the observation of moving targets is an important multirobot application that still exhibits numerous open challenges, including the effective coordination of the robots. This paper reviews control techniques for cooperative mobile robots monitoring multiple targets. The simultaneous movement of robots and targets makes this problem particularly interesting, and our review systematically addresses this cooperative multirobot problem for the first time. We classify and critically discuss the control techniques: cooperative multirobot observation of multiple moving targets, cooperative search, acquisition, and track, cooperative tracking, and multirobot pursuit evasion. We also identify the five major elements that characterize this problem, namely, the coordination method, the environment, the target, the robot and its sensor(s). These elements are used to systematically analyze the control techniques. The majority of the studied work is based on simulation and laboratory studies, which may not accurately reflect real-world operational conditions. Importantly, while our systematic analysis is focused on multitarget observation, our proposed classification is useful also for related multirobot applications.

A preliminary experiment definition for video landmark acquisition and tracking

NASA Technical Reports Server (NTRS)

Schappell, R. T.; Tietz, J. C.; Hulstrom, R. L.; Cunningham, R. A.; Reel, G. M.

1976-01-01

Six scientific objectives/experiments were derived which consisted of agriculture/forestry/range resources, land use, geology/mineral resources, water resources, marine resources and environmental surveys. Computer calculations were then made of the spectral radiance signature of each of 25 candidate targets as seen by a satellite sensor system. An imaging system capable of recognizing, acquiring and tracking specific generic type surface features was defined. A preliminary experiment definition and design of a video Landmark Acquisition and Tracking system is given. This device will search a 10-mile swath while orbiting the earth, looking for land/water interfaces such as coastlines and rivers.

Detection of unknown targets from aerial camera and extraction of simple object fingerprints for the purpose of target reacquisition

NASA Astrophysics Data System (ADS)

Mundhenk, T. Nathan; Ni, Kang-Yu; Chen, Yang; Kim, Kyungnam; Owechko, Yuri

2012-01-01

with the null hypothesis of <20%. Additionally, the performance for fingerprints stays well above the null hypothesis for as much as 800 frames. Thus, a simple and highly compact single Gaussian model is useful for target reacquisition. Since the model is agnostic to view point and object size, it is expected to perform as well on a test of target handoff. Since some of the performance degradation is due to problems with the initial target acquisition and tracking, the simple Gaussian model may perform even better with an improved initial acquisition technique. Also, since the model makes no assumption about the object to be tracked, it should be possible to use it to fingerprint a multitude of objects, not just cars. Further accuracy may be obtained by creating manifolds of objects from multiple samples.

Effects of TEL Confusers on Operator Target Acquisition Performance with SAR Imagery

DTIC Science & Technology

1998-12-01

processing known as the theory of signal detection (TSD) (Gescheider, 1985; Green & Swets, 1966; Macmillan & Creelman , 1991; Wilson, 1992). A TSD...localizations (Hacker & Ratcliff, 1979; Macmillan & Creelman , 1991). The index of bias in a target localization task provides a measure of the operator’s...of correct localizations substituted for hits (Macmillan & Creelman , 1991). Receiver Operating Characteristic Curves. In addition to the calculation

78 FR 13544 - Defense Federal Acquisition Regulation Supplement: Acquisition of Tents and Other Temporary...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... acquisition of domestic tents to include the structural components of tents, applicable to acquisitions that... rule. A. Tents and Structural Components of Tents Question: Does the term ``structural components... 225.7002-1(a)(3) and 252.225-7012(b)(3) ensures clarity that the phrase ``structural components'' only...

48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Interagency Fleet Management System...

Learning the manifold of quality ultrasound acquisition.

PubMed

El-Zehiry, Noha; Yan, Michelle; Good, Sara; Fang, Tong; Zhou, S Kevin; Grady, Leo

2013-01-01

Ultrasound acquisition is a challenging task that requires simultaneous adjustment of several acquisition parameters (the depth, the focus, the frequency and its operation mode). If the acquisition parameters are not properly chosen, the resulting image will have a poor quality and will degrade the patient diagnosis and treatment workflow. Several hardware-based systems for autotuning the acquisition parameters have been previously proposed, but these solutions were largely abandoned because they failed to properly account for tissue inhomogeneity and other patient-specific characteristics. Consequently, in routine practice the clinician either uses population-based parameter presets or manually adjusts the acquisition parameters for each patient during the scan. In this paper, we revisit the problem of autotuning the acquisition parameters by taking a completely novel approach and producing a solution based on image analytics. Our solution is inspired by the autofocus capability of conventional digital cameras, but is significantly more challenging because the number of acquisition parameters is large and the determination of "good quality" images is more difficult to assess. Surprisingly, we show that the set of acquisition parameters which produce images that are favored by clinicians comprise a 1D manifold, allowing for a real-time optimization to maximize image quality. We demonstrate our method for acquisition parameter autotuning on several live patients, showing that our system can start with a poor initial set of parameters and automatically optimize the parameters to produce high quality images.

EXPECT: Explicit Representations for Flexible Acquisition

NASA Technical Reports Server (NTRS)

Swartout, BIll; Gil, Yolanda

1995-01-01

To create more powerful knowledge acquisition systems, we not only need better acquisition tools, but we need to change the architecture of the knowledge based systems we create so that their structure will provide better support for acquisition. Current acquisition tools permit users to modify factual knowledge but they provide limited support for modifying problem solving knowledge. In this paper, the authors argue that this limitation (and others) stem from the use of incomplete models of problem-solving knowledge and inflexible specification of the interdependencies between problem-solving and factual knowledge. We describe the EXPECT architecture which addresses these problems by providing an explicit representation for problem-solving knowledge and intent. Using this more explicit representation, EXPECT can automatically derive the interdependencies between problem-solving and factual knowledge. By deriving these interdependencies from the structure of the knowledge-based system itself EXPECT supports more flexible and powerful knowledge acquisition.

48 CFR 5.405 - Exchange of acquisition information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Exchange of acquisition... ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Release of Information 5.405 Exchange of acquisition... than one contracting activity within an agency, the exchange and coordination of pertinent information...

48 CFR 3032.003 - Simplified acquisition procedures financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Simplified acquisition procedures financing. 3032.003 Section 3032.003 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND... FINANCING Scope of Part 3032.003 Simplified acquisition procedures financing. Contract financing may be...

The role of contextual associations in producing the partial reinforcement acquisition deficit.

PubMed

Miguez, Gonzalo; Witnauer, James E; Miller, Ralph R

2012-01-01

Three conditioned suppression experiments with rats as subjects assessed the contributions of the conditioned stimulus (CS)-context and context-unconditioned stimulus (US) associations to the degraded stimulus control by the CS that is observed following partial reinforcement relative to continuous reinforcement training. In Experiment 1, posttraining associative deflation (i.e., extinction) of the training context after partial reinforcement restored responding to a level comparable to the one produced by continuous reinforcement. In Experiment 2, posttraining associative inflation of the context (achieved by administering unsignaled outcome presentations in the context) enhanced the detrimental effect of partial reinforcement. Experiment 3 found that the training context must be an effective competitor to produce the partial reinforcement acquisition deficit. When the context was down-modulated, the target regained behavioral control thereby demonstrating higher-order retrospective revaluation. The results are discussed in terms of retrospective revaluation, and are used to contrast the predictions of a performance-focused model with those of an acquisition-focused model. (c) 2012 APA, all rights reserved.

Evaluating the Return in Ecosystem Services from Investment in Public Land Acquisitions

PubMed Central

Kovacs, Kent; Polasky, Stephen; Nelson, Erik; Keeler, Bonnie L.; Pennington, Derric; Plantinga, Andrew J.; Taff, Steven J.

2013-01-01

We evaluate the return on investment (ROI) from public land conservation in the state of Minnesota, USA. We use a spatially-explicit modeling tool, the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST), to estimate how changes in land use and land cover (LULC), including public land acquisitions for conservation, influence the joint provision and value of multiple ecosystem services. We calculate the ROI of a public conservation acquisition as the ratio of the present value of ecosystem services generated by the conservation to the cost of the conservation. For the land scenarios analyzed, carbon sequestration services generated the greatest benefits followed by water quality improvements and recreation opportunities. We found ROI values ranged from 0.21 to 5.28 depending on assumptions about future land use change, service values, and discount rate. Our study suggests conservation is a good investment as long as investments are targeted to areas with low land costs and high service values. PMID:23776429

48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Utilization of Energy... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b), insert...

48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Utilization of Energy... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b), insert...

48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Utilization of Energy... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b), insert...

48 CFR 952.226-71 - Utilization of Energy Policy Act target entities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Utilization of Energy... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.226-71 Utilization of Energy Policy Act target entities. As prescribed in 926.7007(b), insert...

Schizophrenia and second language acquisition.

PubMed

Bersudsky, Yuly; Fine, Jonathan; Gorjaltsan, Igor; Chen, Osnat; Walters, Joel

2005-05-01

Language acquisition involves brain processes that can be affected by lesions or dysfunctions in several brain systems and second language acquisition may depend on different brain substrates than first language acquisition in childhood. A total of 16 Russian immigrants to Israel, 8 diagnosed schizophrenics and 8 healthy immigrants, were compared. The primary data for this study were collected via sociolinguistic interviews. The two groups use language and learn language in very much the same way. Only exophoric reference and blocking revealed meaningful differences between the schizophrenics and healthy counterparts. This does not mean of course that schizophrenia does not induce language abnormalities. Our study focuses on those aspects of language that are typically difficult to acquire in second language acquisition. Despite the cognitive compromises in schizophrenia and the manifest atypicalities in language of speakers with schizophrenia, the process of acquiring a second language seems relatively unaffected by schizophrenia.

26 CFR 1.279-3 - Corporate acquisition indebtedness.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Corporate acquisition indebtedness. 1.279-3... TAX (CONTINUED) INCOME TAXES Items Not Deductible § 1.279-3 Corporate acquisition indebtedness. (a) Corporate acquisition indebtedness. For purposes of section 279, the term corporate acquisition indebtedness...

48 CFR 218.170 - Additional acquisition flexibilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available... circumstances. See PGI 206.302-2. (b) Use of advance Military Interdepartmental Purchase Request (MIPR). For...

48 CFR 218.170 - Additional acquisition flexibilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available... circumstances. See PGI 206.302-2. (b) Use of advance Military Interdepartmental Purchase Request (MIPR). For...

48 CFR 218.170 - Additional acquisition flexibilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available... circumstances. See PGI 206.302-2. (b) Use of advance Military Interdepartmental Purchase Request (MIPR). For...

48 CFR 218.170 - Additional acquisition flexibilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... flexibilities. 218.170 Section 218.170 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available... circumstances. See PGI 206.302-2. (b) Use of advance Military Interdepartmental Purchase Request (MIPR). For...

48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Interagency Fleet Management System (IFMS) Contract clause. FAR Index Federal...

48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Interagency Fleet Management System (IFMS) Contract clause. FAR Index Federal...

48 CFR 1519.501 - Review of acquisitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Review of acquisitions. 1519.501 Section 1519.501 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... (SBS) shall initiate recommendations to the Contracting Officer for small business set-asides with...

PECAN: library-free peptide detection for data-independent acquisition tandem mass spectrometry data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ting, Ying S.; Egertson, Jarrett D.; Bollinger, James G.

Data-independent acquisition (DIA) is an emerging mass spectrometry (MS)-based technique for unbiased and reproducible measurement of protein mixtures. DIA tandem mass spectrometry spectra are often highly multiplexed, containing product ions from multiple cofragmenting precursors. Detecting peptides directly from DIA data is therefore challenging; most DIA data analyses require spectral libraries. Here we present PECECAN (http://pecan.maccosslab.org), a library-free, peptide-centric tool that robustly and accurately detects peptides directly from DIA data. PECECAN reports evidence of detection based on product ion scoring, which enables detection of low-abundance analytes with poor precursor ion signal. We demonstrate the chromatographic peak picking accuracy and peptide detectionmore » capability of PECECAN, and we further validate its detection with data-dependent acquisition and targeted analyses. Lastly, we used PECECAN to build a plasma proteome library from DIA data and to query known sequence variants.« less

77 FR 30365 - Defense Federal Acquisition Regulation Supplement: Report on Waiver of Prohibition on Acquisition...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... Chinese Military Companies (DFARS Case 2012-D023) AGENCY: Defense Acquisition Regulations System... of the prohibition on acquisition of United States Munitions List items from Communist Chinese... List items from Communist Chinese military companies. The prior requirement was for a report within 30...

Pose measurement method and experiments for high-speed rolling targets in a wind tunnel.

PubMed

Jia, Zhenyuan; Ma, Xin; Liu, Wei; Lu, Wenbo; Li, Xiao; Chen, Ling; Wang, Zhengqu; Cui, Xiaochun

2014-12-12

High-precision wind tunnel simulation tests play an important role in aircraft design and manufacture. In this study, a high-speed pose vision measurement method is proposed for high-speed and rolling targets in a supersonic wind tunnel. To obtain images with high signal-to-noise ratio and avoid impacts on the aerodynamic shape of the rolling targets, a high-speed image acquisition method based on ultrathin retro-reflection markers is presented. Since markers are small-sized and some of them may be lost when the target is rolling, a novel markers layout with which markers are distributed evenly on the surface is proposed based on a spatial coding method to achieve highly accurate pose information. Additionally, a pose acquisition is carried out according to the mentioned markers layout after removing mismatching points by Case Deletion Diagnostics. Finally, experiments on measuring the pose parameters of high-speed targets in the laboratory and in a supersonic wind tunnel are conducted to verify the feasibility and effectiveness of the proposed method. Experimental results indicate that the position measurement precision is less than 0.16 mm, the pitching and yaw angle precision less than 0.132° and the roll angle precision 0.712°.

Pose Measurement Method and Experiments for High-Speed Rolling Targets in a Wind Tunnel

PubMed Central

Jia, Zhenyuan; Ma, Xin; Liu, Wei; Lu, Wenbo; Li, Xiao; Chen, Ling; Wang, Zhengqu; Cui, Xiaochun

2014-01-01

High-precision wind tunnel simulation tests play an important role in aircraft design and manufacture. In this study, a high-speed pose vision measurement method is proposed for high-speed and rolling targets in a supersonic wind tunnel. To obtain images with high signal-to-noise ratio and avoid impacts on the aerodynamic shape of the rolling targets, a high-speed image acquisition method based on ultrathin retro-reflection markers is presented. Since markers are small-sized and some of them may be lost when the target is rolling, a novel markers layout with which markers are distributed evenly on the surface is proposed based on a spatial coding method to achieve highly accurate pose information. Additionally, a pose acquisition is carried out according to the mentioned markers layout after removing mismatching points by Case Deletion Diagnostics. Finally, experiments on measuring the pose parameters of high-speed targets in the laboratory and in a supersonic wind tunnel are conducted to verify the feasibility and effectiveness of the proposed method. Experimental results indicate that the position measurement precision is less than 0.16 mm, the pitching and yaw angle precision less than 0.132° and the roll angle precision 0.712°. PMID:25615732

Acquisition, representation and rule generation for procedural knowledge

NASA Technical Reports Server (NTRS)

Ortiz, Chris; Saito, Tim; Mithal, Sachin; Loftin, R. Bowen

1991-01-01

Current research into the design and continuing development of a system for the acquisition of procedural knowledge, its representation in useful forms, and proposed methods for automated C Language Integrated Production System (CLIPS) rule generation is discussed. The Task Analysis and Rule Generation Tool (TARGET) is intended to permit experts, individually or collectively, to visually describe and refine procedural tasks. The system is designed to represent the acquired knowledge in the form of graphical objects with the capacity for generating production rules in CLIPS. The generated rules can then be integrated into applications such as NASA's Intelligent Computer Aided Training (ICAT) architecture. Also described are proposed methods for use in translating the graphical and intermediate knowledge representations into CLIPS rules.

32 CFR 644.102 - Examples of involuntary acquisitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Examples of involuntary acquisitions. 644.102... PROPERTY REAL ESTATE HANDBOOK Acquisition Involuntary Acquisition by the United States § 644.102 Examples... property, as prescribed by Pub. L. 91-646. Examples of involuntary acquisition are: (a) Damage to real...

Business Acquisition and Implementation

DTIC Science & Technology

2006-01-01

I am proposing that this technical paper be broken down into two phases. Phase one will consist of business and land acquisition. Phase two will...consist of business implementation. The business acquisition phase will document the process of forming a limited liability company (LLC) from a sole...proprietorship with the intention of real estate development and personal asset protection. I do not require a business license but I will need to

48 CFR 18.113 - Interagency acquisitions under the Economy Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Interagency acquisitions under the Economy Act. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities 18.113 Interagency acquisitions under...

75 FR 10567 - Commerce Acquisition Regulation (CAR)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... acquisitions, contract financing, protests, disputes, and appeals, major system acquisitions, research and... appeals. SUBCHAPTER F--SPECIAL CATEGORIES OF CONTRACTING 1334 Major system acquisition. 1335 Research and....603-2, selection of contracting officers shall be based upon Section 4 of CAM 1301.6. 1301.603-3...

Air-to-Ground Target Acquisition Source Book: A Review of the Literature

DTIC Science & Technology

1974-09-30

Verbal Countdown and No- Countdown Conditions . . . ’ 5-50 S-27 The Effects on Target Recognitio Proficiency ofVarying ’ Scn’ Time and of Display Aids...Dad(D)d4Wat4ao~tt Inter’ J194 ttre’tlo vsvisbleo (1) tsit.n logo proaraiti to olulsto fixed IOv thrl"i.,l. cloture ’A tarpato at 4C1slre4 rtes (I

23 CFR 710.309 - Acquisition.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Acquisition. 710.309 Section 710.309 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT RIGHT-OF-WAY AND REAL ESTATE Project Development § 710.309 Acquisition. The process of acquiring real property includes...

Acquisition Policies. SPEC Kit 12.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC. Office of Management Studies.

This collection of acquisition materials from member libraries of the Association of Research Libraries (ARL) contains: (1) acquisition policies from Brigham Young University, Iowa State University, and the University of Cincinnati; (2) book selection policies from the University of Nebraska Undergraduate Library and Georgetown University; (3) an…

Use of commercial off-the-shelf digital cameras for scientific data acquisition and scene-specific color calibration

PubMed Central

Akkaynak, Derya; Treibitz, Tali; Xiao, Bei; Gürkan, Umut A.; Allen, Justine J.; Demirci, Utkan; Hanlon, Roger T.

2014-01-01

Commercial off-the-shelf digital cameras are inexpensive and easy-to-use instruments that can be used for quantitative scientific data acquisition if images are captured in raw format and processed so that they maintain a linear relationship with scene radiance. Here we describe the image-processing steps required for consistent data acquisition with color cameras. In addition, we present a method for scene-specific color calibration that increases the accuracy of color capture when a scene contains colors that are not well represented in the gamut of a standard color-calibration target. We demonstrate applications of the proposed methodology in the fields of biomedical engineering, artwork photography, perception science, marine biology, and underwater imaging. PMID:24562030

Improving quality of laser scanning data acquisition through calibrated amplitude and pulse deviation measurement

NASA Astrophysics Data System (ADS)

Pfennigbauer, Martin; Ullrich, Andreas

2010-04-01

Newest developments in laser scanner technologies put surveyors in the position to comply with the ever increasing demand of high-speed, high-accuracy, and highly reliable data acquisition from terrestrial, mobile, and airborne platforms. Echo digitization in pulsed time-of-flight laser ranging has demonstrated its superior performance in the field of bathymetry and airborne laser scanning for more than a decade, however at the cost of somewhat time consuming off line post processing. State-of-the-art online waveform processing as implemented in RIEGL's V-Line not only saves users post-processing time to obtain true 3D point clouds, it also adds the assets of calibrated amplitude and reflectance measurement for data classification and pulse deviation determination for effective and reliable data validation. We present results from data acquisitions in different complex target situations.

Fast data transmission in dynamic data acquisition system for plasma diagnostics

NASA Astrophysics Data System (ADS)

Byszuk, Adrian; Poźniak, Krzysztof; Zabołotny, Wojciech M.; Kasprowicz, Grzegorz; Wojeński, Andrzej; Cieszewski, Radosław; Juszczyk, Bartłomiej; Kolasiński, Piotr; Zienkiewicz, Paweł; Chernyshova, Maryna; Czarski, Tomasz

2014-11-01

This paper describes architecture of a new data acquisition system (DAQ) targeted mainly at plasma diagnostic experiments. Modular architecture, in combination with selected hardware components, allows for straightforward reconfiguration of the whole system, both offline and online. Main emphasis will be put into the implementation of data transmission subsystem in said system. One of the biggest advantages of described system is modular architecture with well defined boundaries between main components: analog frontend (AFE), digital backplane and acquisition/control software. Usage of a FPGA chips allows for a high flexibility in design of analog frontends, including ADC <--> FPGA interface. Data transmission between backplane boards and user software was accomplished with the use of industry-standard PCI Express (PCIe) technology. PCIe implementation includes both FPGA firmware and Linux device driver. High flexibility of PCIe connections was accomplished due to use of configurable PCIe switch. Whenever it's possible, described DAQ system tries to make use of standard off-the-shelf (OTF) components, including typical x86 CPU & motherboard (acting as PCIe controller) and cabling.

The Acquisition of Neg-V and V-Neg Order in Embedded Clauses in Swedish: A Microparametric Approach

ERIC Educational Resources Information Center

Waldmann, Christian

2014-01-01

This article examines the acquisition of embedded verb placement in Swedish children, focusing on Neg-V and V-Neg order. It is proposed that a principle of economy of movement creates an overuse of V-Neg order in embedded clauses and that the low frequency of the target-consistent Neg-V order in child-directed speech obstructs children from…

A technique for thick polymer coating of inertial-confinement-fusion targets

NASA Technical Reports Server (NTRS)

Lee, M. C.; Feng, I.-A.; Wang, T. G.; Kim, H.-G.

1983-01-01

A technique to coat a stalk-mounted inertial-confinement fusion (ICF) target with a thick polymer layer has been successfully demonstrated. The polymer solution is first atomized, allowed to coalesce into a droplet, and positioned in a stable acoustic levitating field. The stalk-mounted ICF target is then moved into the acoustic field by manipulating a 3-D positioner to penetrate the surface membrane of the droplet, thus immersing the target in the levitated coating solution. The target inside the droplet is maintained at the center of the levitated liquid using the 3-D positional information provided by two orthogonally placed TV cameras until the drying process is completed. The basic components of the experimental apparatus, including an acoustic levitator, liquid sample deployment device, image acquisition instrumentation, and 3-D positioner, are briefly described.

75 FR 39420 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-44; Small Entity Compliance Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

... Federal Acquisition Circular (FAC) 2005-44 which amends the Federal Acquisition Regulation (FAR). Interested parties may obtain further information regarding this rule by referring to FAC 2005-44 which... . FOR FURTHER INFORMATION CONTACT: The analyst whose name appears in the table below. Please cite FAC...

48 CFR 1480.102 - Buy Indian Act acquisition regulations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Buy Indian Act acquisition... INDIAN AFFAIRS SUPPLEMENT ACQUISITIONS UNDER THE BUY INDIAN ACT Subpart 1480.1 General 1480.102 Buy Indian Act acquisition regulations. (a) This part supplements Federal Acquisition Regulation (FAR) and...

The acquisition of contextual cueing effects by persons with and without intellectual disability.

PubMed

Merrill, Edward C; Conners, Frances A; Yang, Yingying; Weathington, Dana

2014-10-01

Two experiments were conducted to compare the acquisition of contextual cueing effects of adolescents and young adults with intellectual disabilities (ID) relative to typically developing children and young adults. Contextual cueing reflects an implicit, memory based attention guidance mechanism that results in faster search for target locations that have been previously experienced in a predictable context. In the study, participants located a target stimulus embedded in a context of numerous distracter stimuli. During a learning phase, the location of the target was predictable from the location of the distracters in the search displays. We then compared response times to locating predictable relative to unpredictable targets presented in a test phase. In Experiment 1, all of the distracters predicted the location of the target. In Experiment 2, half of the distracters predicted the location of the target while the other half varied randomly. The participants with ID exhibited significant contextual facilitation in both experiments, with the magnitude of facilitation being similar to that of the typically developing (TD) children and adults. We concluded that deficiencies in contextual cueing are not necessarily associated with low measured intelligence that results in a classification of ID. Copyright © 2014 Elsevier Ltd. All rights reserved.

Centaur propellant acquisition system

NASA Technical Reports Server (NTRS)

Blatt, M. H.; Aydelott, J. C.

1975-01-01

The desirability of replacing the hydrogen peroxide settling system of the Centaur D-1S with a capillary acquisition system was evaluated. A comprehensive screening was performed to select the most promising capillary device fluid acquisition, thermal conditioning, and fabrication techniques. Refillable start baskets and bypass feed start tanks were selected for detailed design. Critical analysis areas were settling and refilling, start sequence development with an initially dry boost pump, and cooling the fluid delivered to the boost pump to provide the necessary net positive suction head (NPSH). Design drawings were prepared for start basket and start tank concepts for both the liquid oxygen and liquid hydrogen tanks. System comparisons indicated that the start baskets using wicking flow for thermal conditioning, and thermal subcooling for providing boost pump NPSH, are the most desirable systems for future Centaur acquisition system development.

Developing capital investment guidelines for acquisitions.

PubMed

Bergman, J T; Gordon, D C

1988-05-01

Financial managers are now being asked to evaluate new investment opportunities, such as acquisitions. To do a thorough evaluation, however, it is important to have a plan of action to follow. Strategies such as establishing a framework for evaluating acquisitions based on strategic compatibility with the existing organization, establishing suitable risk-adjusted discount rates for assessing investments, and selecting the proper type of capital allocation method are all necessary steps to ensure a successful acquisition.

A Production System Model of Capturing Reactive Moving Targets. M.S. Thesis

NASA Technical Reports Server (NTRS)

Jagacinski, R. J.; Plamondon, B. D.; Miller, R. A.

1984-01-01

Subjects manipulated a control stick to position a cursor over a moving target that reacted with a computer-generated escape strategy. The cursor movements were described at two levels of abstraction. At the upper level, a production system described transitions among four modes of activity; rapid acquisition, close following, a predictive mode, and herding. Within each mode, differential equations described trajectory-generating mechanisms. A simulation of this two-level model captures the targets in a manner resembling the episodic time histories of human subjects.

48 CFR 207.401 - Acquisition considerations.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF DEFENSE ACQUISITION PLANNING ACQUISITION PLANNING Equipment Lease or Purchase 207.401... prepare and provide the contracting officer with the justification supporting the decision to lease or purchase. ...

7 CFR 982.16 - Inshell trade acquisitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Inshell trade acquisitions. 982.16 Section 982.16... WASHINGTON Order Regulating Handling Definitions § 982.16 Inshell trade acquisitions. Inshell trade acquisitions means the quantity of inshell hazelnuts acquired by the trade from all handlers during a marketing...

7 CFR 982.16 - Inshell trade acquisitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Inshell trade acquisitions. 982.16 Section 982.16... WASHINGTON Order Regulating Handling Definitions § 982.16 Inshell trade acquisitions. Inshell trade acquisitions means the quantity of inshell hazelnuts acquired by the trade from all handlers during a marketing...

7 CFR 982.16 - Inshell trade acquisitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 8 2014-01-01 2014-01-01 false Inshell trade acquisitions. 982.16 Section 982.16... WASHINGTON Order Regulating Handling Definitions § 982.16 Inshell trade acquisitions. Inshell trade acquisitions means the quantity of inshell hazelnuts acquired by the trade from all handlers during a marketing...

7 CFR 982.16 - Inshell trade acquisitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Inshell trade acquisitions. 982.16 Section 982.16... WASHINGTON Order Regulating Handling Definitions § 982.16 Inshell trade acquisitions. Inshell trade acquisitions means the quantity of inshell hazelnuts acquired by the trade from all handlers during a marketing...

Identification of ground targets from airborne platforms

NASA Astrophysics Data System (ADS)

Doe, Josh; Boettcher, Evelyn; Miller, Brian

2009-05-01

The US Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD) sensor performance models predict the ability of soldiers to perform a specified military discrimination task using an EO/IR sensor system. Increasingly EO/IR systems are being used on manned and un-manned aircraft for surveillance and target acquisition tasks. In response to this emerging requirement, the NVESD Modeling and Simulation division has been tasked to compare target identification performance between ground-to-ground and air-to-ground platforms for both IR and visible spectra for a set of wheeled utility vehicles. To measure performance, several forced choice experiments were designed and administered and the results analyzed. This paper describes these experiments and reports the results as well as the NVTherm model calibration factors derived for the infrared imagery.

Space storable propellant acquisition system

NASA Technical Reports Server (NTRS)

Tegart, J. R.; Uney, P. E.; Anderson, J. E.; Fester, D. A.

1972-01-01

Surface tension propellant acquisition concepts for an advanced spacecraft propulsion system having a 10-year mission capability were investigated. Surface tension systems were specified because they were shown to be the best propellant acquisition technique for various interplanetery spacecraft in a prior study. A variety of surface tension concepts for accomplishing propellant acquisition were formulated for the baseline space storable propulsion module and Jupiter Orbiter mission. Analyses and evaluations were then conducted on each candidate concept to assess fabricability, performance capability, and spacecraft compatibility. A comparative evaluation of the results showed the Fruhof-class of low-g surface tension systems to be preferred for these interplanetary applications.

War-gaming application for future space systems acquisition: MATLAB implementation of war-gaming acquisition models and simulation results

NASA Astrophysics Data System (ADS)

Vienhage, Paul; Barcomb, Heather; Marshall, Karel; Black, William A.; Coons, Amanda; Tran, Hien T.; Nguyen, Tien M.; Guillen, Andy T.; Yoh, James; Kizer, Justin; Rogers, Blake A.

2017-05-01

The paper describes the MATLAB (MathWorks) programs that were developed during the REU workshop1 to implement The Aerospace Corporation developed Unified Game-based Acquisition Framework and Advanced Game - based Mathematical Framework (UGAF-AGMF) and its associated War-Gaming Engine (WGE) models. Each game can be played from the perspectives of the Department of Defense Acquisition Authority (DAA) or of an individual contractor (KTR). The programs also implement Aerospace's optimum "Program and Technical Baseline (PTB) and associated acquisition" strategy that combines low Total Ownership Cost (TOC) with innovative designs while still meeting warfighter needs. The paper also describes the Bayesian Acquisition War-Gaming approach using Monte Carlo simulations, a numerical analysis technique to account for uncertainty in decision making, which simulate the PTB development and acquisition processes and will detail the procedure of the implementation and the interactions between the games.

32 CFR 644.7 - Acquisition lines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... HANDBOOK Project Planning Civil Works § 644.7 Acquisition lines. (a) Tentative acquisition lines. As..., in accordance with sound real estate practices. Accordingly, fringe tracts will not be acquired until...

Syntactic Markedness and Language Acquisition.

ERIC Educational Resources Information Center

Mazurkewich, Irene

1985-01-01

Argues that Chomsky's theory of generative grammar provides a model for second language acquisition that meets the criteria of descriptive and exploratory adequacy in accounting for the language learning process. Illustrates this by presenting data on the acquisition of dative complements and dative questions in a passive context by second…

Reducing acquisition time in clinical MRI by data undersampling and compressed sensing reconstruction

NASA Astrophysics Data System (ADS)

Hollingsworth, Kieren Grant

2015-11-01

MRI is often the most sensitive or appropriate technique for important measurements in clinical diagnosis and research, but lengthy acquisition times limit its use due to cost and considerations of patient comfort and compliance. Once an image field of view and resolution is chosen, the minimum scan acquisition time is normally fixed by the amount of raw data that must be acquired to meet the Nyquist criteria. Recently, there has been research interest in using the theory of compressed sensing (CS) in MR imaging to reduce scan acquisition times. The theory argues that if our target MR image is sparse, having signal information in only a small proportion of pixels (like an angiogram), or if the image can be mathematically transformed to be sparse then it is possible to use that sparsity to recover a high definition image from substantially less acquired data. This review starts by considering methods of k-space undersampling which have already been incorporated into routine clinical imaging (partial Fourier imaging and parallel imaging), and then explains the basis of using compressed sensing in MRI. The practical considerations of applying CS to MRI acquisitions are discussed, such as designing k-space undersampling schemes, optimizing adjustable parameters in reconstructions and exploiting the power of combined compressed sensing and parallel imaging (CS-PI). A selection of clinical applications that have used CS and CS-PI prospectively are considered. The review concludes by signposting other imaging acceleration techniques under present development before concluding with a consideration of the potential impact and obstacles to bringing compressed sensing into routine use in clinical MRI.

16 CFR 801.32 - Conversion and acquisition.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Conversion and acquisition. 801.32 Section... INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.32 Conversion and acquisition. A conversion is an acquisition within the meaning of the act. Example: Assume that...

16 CFR 801.32 - Conversion and acquisition.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Conversion and acquisition. 801.32 Section... INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 COVERAGE RULES § 801.32 Conversion and acquisition. A conversion is an acquisition within the meaning of the act. Example: Assume that...

Hierarchical acquisition of visual specificity in spatial contextual cueing.

PubMed

Lie, Kin-Pou

2015-01-01

Spatial contextual cueing refers to visual search performance's being improved when invariant associations between target locations and distractor spatial configurations are learned incidentally. Using the instance theory of automatization and the reverse hierarchy theory of visual perceptual learning, this study explores the acquisition of visual specificity in spatial contextual cueing. Two experiments in which detailed visual features were irrelevant for distinguishing between spatial contexts found that spatial contextual cueing was visually generic in difficult trials when the trials were not preceded by easy trials (Experiment 1) but that spatial contextual cueing progressed to visual specificity when difficult trials were preceded by easy trials (Experiment 2). These findings support reverse hierarchy theory, which predicts that even when detailed visual features are irrelevant for distinguishing between spatial contexts, spatial contextual cueing can progress to visual specificity if the stimuli remain constant, the task is difficult, and difficult trials are preceded by easy trials. However, these findings are inconsistent with instance theory, which predicts that when detailed visual features are irrelevant for distinguishing between spatial contexts, spatial contextual cueing will not progress to visual specificity. This study concludes that the acquisition of visual specificity in spatial contextual cueing is more plausibly hierarchical, rather than instance-based.

77 FR 23371 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-58; Small Entity Compliance Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Federal Acquisition Circular (FAC) 2005-58, which amends the Federal Acquisition Regulation (FAR). An... parties may obtain further information regarding this rule by referring to FAC 2005-58, which precedes... analyst whose name appears in the table below. Please cite FAC 2005-58 and the FAR case number. For...

78 FR 13769 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-66; Small Entity Compliance Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... Federal Acquisition Circular (FAC) 2005-66, which amends the Federal Acquisition Regulation (FAR). An... parties may obtain further information regarding this rule by referring to FAC 2005-66, which precedes... analyst whose name appears in the table below. Please cite FAC 2005-66 and the FAR case number. For...

76 FR 4191 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-49; Small Entity Compliance Guide

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... Federal Acquisition Circular (FAC) 2005-49, which amend the Federal Acquisition Regulation (FAR). Interested parties may obtain further information regarding these rules by referring to FAC 2005-49, which... analyst whose name appears in the table below. Please cite FAC 2005-49 and the specific FAR case number...

Intelligence, mapping, and geospatial exploitation system (IMAGES)

NASA Astrophysics Data System (ADS)

Moellman, Dennis E.; Cain, Joel M.

1998-08-01

This paper provides further detail to one facet of the battlespace visualization concept described in last year's paper Battlespace Situation Awareness for Force XXI. It focuses on the National Imagery and Mapping Agency (NIMA) goal to 'provide customers seamless access to tailorable imagery, imagery intelligence, and geospatial information.' This paper describes Intelligence, Mapping, and Geospatial Exploitation System (IMAGES), an exploitation element capable of CONUS baseplant operations or field deployment to provide NIMA geospatial information collaboratively into a reconnaissance, surveillance, and target acquisition (RSTA) environment through the United States Imagery and Geospatial Information System (USIGS). In a baseplant CONUS setting IMAGES could be used to produce foundation data to support mission planning. In the field it could be directly associated with a tactical sensor receiver or ground station (e.g. UAV or UGV) to provide near real-time and mission specific RSTA to support mission execution. This paper provides IMAGES functional level design; describes the technologies, their interactions and interdependencies; and presents a notional operational scenario to illustrate the system flexibility. Using as a system backbone an intelligent software agent technology, called Open Agent ArchitectureTM (OAATM), IMAGES combines multimodal data entry, natural language understanding, and perceptual and evidential reasoning for system management. Configured to be DII COE compliant, it would utilize, to the extent possible, COTS applications software for data management, processing, fusion, exploitation, and reporting. It would also be modular, scaleable, and reconfigurable. This paper describes how the OAATM achieves data synchronization and enables the necessary level of information to be rapidly available to various command echelons for making informed decisions. The reasoning component will provide for the best information to be developed in the timeline

Cybersecurity:The Road Ahead for Defense Acquisition

DTIC Science & Technology

2016-06-01

tion programs. A key challenge for DoD acquisition addressing the cyber threat is how do we “ bake in” cybersecurity for our DoD ac- quisition programs...cybersecurity must be “ baked in” the design of our warfighting systems. Supporting policy and best practices for effective cyberse- curity in acquisition...contacted at steve.mills@dau.mil and steve.monks@ dau.mil. A key challenge for DoD acquisition addressing the cyber threat is how do we “ bake in” cybersecurity for our DoD acquisition programs vs. “bolting it on.”

48 CFR 873.105 - Acquisition planning.

Code of Federal Regulations, 2012 CFR

2012-10-01

... procedures, the contracting officer or the acquisition team, as appropriate, must conduct market research to..., briefing materials shall be presented to address the acquisition plan topics and structure in FAR 7.105...

48 CFR 873.105 - Acquisition planning.

Code of Federal Regulations, 2011 CFR

2011-10-01

... procedures, the contracting officer or the acquisition team, as appropriate, must conduct market research to..., briefing materials shall be presented to address the acquisition plan topics and structure in FAR 7.105...

48 CFR 873.105 - Acquisition planning.

Code of Federal Regulations, 2014 CFR

2014-10-01

... procedures, the contracting officer or the acquisition team, as appropriate, must conduct market research to..., briefing materials shall be presented to address the acquisition plan topics and structure in FAR 7.105...

48 CFR 873.105 - Acquisition planning.

Code of Federal Regulations, 2013 CFR

2013-10-01

... procedures, the contracting officer or the acquisition team, as appropriate, must conduct market research to..., briefing materials shall be presented to address the acquisition plan topics and structure in FAR 7.105...

48 CFR 873.105 - Acquisition planning.

Code of Federal Regulations, 2010 CFR

2010-10-01

... procedures, the contracting officer or the acquisition team, as appropriate, must conduct market research to..., briefing materials shall be presented to address the acquisition plan topics and structure in FAR 7.105...

Three-dimensional calibration targets for optical coherence tomography

NASA Astrophysics Data System (ADS)

Gabriele Sandrian, Michelle; Tomlins, Pete; Woolliams, Peter; Rasakanthan, Janarthanan; Lee, Graham C.; Yang, Anna; Považay, Boris; Alex, Aneesh; Sugden, Kate; Drexler, Wolfgang

2012-03-01

The recent expansion of clinical applications for optical coherence tomography (OCT) is driving the development of approaches for consistent image acquisition. There is a simultaneous need for time-stable, easy-to-use imaging targets for calibration and standardization of OCT devices. We present calibration targets consisting of three-dimensional structures etched into nanoparticle-embedded resin. Spherical iron oxide nanoparticles with a predominant particle diameter of 400 nm were homogeneously dispersed in a two part polyurethane resin and allowed to harden overnight. These samples were then etched using a precision micromachining femtosecond laser with a center wavelength of 1026 nm, 100kHz repetition rate and 450 fs pulse duration. A series of lines in depth were etched, varying the percentage of inscription energy and speed of the translation stage moving the target with respect to the laser. Samples were imaged with a dual wavelength spectral-domain OCT system (λ=800nm, ▵λ~180nm, and λ=1325nm, ▵λ~100nm) and point-spread function of nanoparticles within the target was measured.

School Libraries Addressing the Needs of ELL Students: Enhancing Language Acquisition, Confidence, and Cultural Fluency in ELL Students by Developing a Targeted Collection and Enriching Your Makerspace

ERIC Educational Resources Information Center

Murphy, Peggy Henderson

2018-01-01

English Language Learner (ELL) students are sometimes a small constituency. Many resources already in the library can be used to enhance their language acquisition, confidence, and cultural fluency--resources such as graphic novels, hi-lo books, and makerspace materials. This article discusses enhancing language acquisition, confidence, and…

Knowledge Acquisition in Observational Astronomy.

ERIC Educational Resources Information Center

Vosniadou, Stella

This paper presents findings from research on knowledge acquisition in observational astronomy to demonstrate the kinds of intuitive models children form and to show how these models influence the acquisition of science knowledge. Sixty children of approximate ages 6, 9, and 12 were given a questionnaire to investigate their knowledge of the size,…

Image acquisition device of inspection robot based on adaptive rotation regulation of polarizer

NASA Astrophysics Data System (ADS)

Dong, Maoqi; Wang, Xingguang; Liang, Tao; Yang, Guoqing; Zhang, Chuangyou; Gao, Faqin

2017-12-01

An image processing device of inspection robot with adaptive polarization adjustment is proposed, that the device includes the inspection robot body, the image collecting mechanism, the polarizer and the polarizer automatic actuating device. Where, the image acquisition mechanism is arranged at the front of the inspection robot body for collecting equipment image data in the substation. Polarizer is fixed on the automatic actuating device of polarizer, and installed in front of the image acquisition mechanism, and that the optical axis of the camera vertically goes through the polarizer and the polarizer rotates with the optical axis of the visible camera as the central axis. The simulation results show that the system solves the fuzzy problems of the equipment that are caused by glare, reflection of light and shadow, and the robot can observe details of the running status of electrical equipment. And the full coverage of the substation equipment inspection robot observation target is achieved, which ensures the safe operation of the substation equipment.

Acquisition of Crosswell Seismic Monitoring Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daley, T.M.; Niu, F.; Silver, P.G.

2008-02-15

Crosswell seismic acquisition provides an ideal geometry for monitoring travel time changes in the subsurface. Analysis of delay time in terms of a characteristic frequency allows us to estimate optimal acquisition parameters (frequency and distance). We have deployed standard data acquisition equipment for continuous monitoring of crosswell travel time in two separate field experiments, with well spacing of 3 and 30 m. The acquisition hardware used for the field experiments is described, along with environmental effects (such as temperature) that influence the measurements. Two field experiments are described that correlate changes in travel time (and therefore velocity) with changes inmore » barometric pressure. The results from the two field sites show a pressure sensitivity for velocity of 10{sup -6}/Pa to 10{sup -8}/Pa.« less

Handbook of Child Language Acquisition.

ERIC Educational Resources Information Center

Ritchie, William C., Ed.; Bhatia, Tej K., Ed.

This volume provides a comprehensive overview of the major areas of research in the field of child language acquisition. It is divided into seven parts and 19 chapters. Part I is an introduction and overview. Part II covers central issues in the study of child language acquisition, focusing on syntax, including those of innateness, maturation, and…

Complex System Governance for Acquisition

DTIC Science & Technology

2016-04-30

2014, September–October). Cybersecurity challenges for program managers . Defense AT&L. Naphade, M., Banavar, G., Harrison, C., Paraszczak, J...the Acquisition Research Program of the Graduate School of Business & Public Policy at the Naval Postgraduate School. To request defense...Dickmann, Vice President, Sonalysts Inc. A Complex Systems Perspective of Risk Mitigation and Modeling in Development and Acquisition Programs Roshanak

Managing Uncertainty during a Corporate Acquisition: A Longitudinal Study of Communication During an Airline Acquisition

ERIC Educational Resources Information Center

Kramer, Michael W.; Dougherty, Debbie S.; Pierce, Tamyra A.

2004-01-01

This study examined pilots' (N at T1 = 140; N at T2 = 126; N at T3 = 104) reactions to communication and uncertainty during the acquisition of their airline by another airline. Quantitative results indicate that communication helped to reduce uncertainty and was predictive of affective responses to the acquisition. However, contrary to…

Advances in targeted proteomics and applications to biomedical research

PubMed Central

Shi, Tujin; Song, Ehwang; Nie, Song; Rodland, Karin D.; Liu, Tao; Qian, Wei-Jun; Smith, Richard D.

2016-01-01

Targeted proteomics technique has emerged as a powerful protein quantification tool in systems biology, biomedical research, and increasing for clinical applications. The most widely used targeted proteomics approach, selected reaction monitoring (SRM), also known as multiple reaction monitoring (MRM), can be used for quantification of cellular signaling networks and preclinical verification of candidate protein biomarkers. As an extension to our previous review on advances in SRM sensitivity herein we review recent advances in the method and technology for further enhancing SRM sensitivity (from 2012 to present), and highlighting its broad biomedical applications in human bodily fluids, tissue and cell lines. Furthermore, we also review two recently introduced targeted proteomics approaches, parallel reaction monitoring (PRM) and data-independent acquisition (DIA) with targeted data extraction on fast scanning high-resolution accurate-mass (HR/AM) instruments. Such HR/AM targeted quantification with monitoring all target product ions addresses SRM limitations effectively in specificity and multiplexing; whereas when compared to SRM, PRM and DIA are still in the infancy with a limited number of applications. Thus, for HR/AM targeted quantification we focus our discussion on method development, data processing and analysis, and its advantages and limitations in targeted proteomics. Finally, general perspectives on the potential of achieving both high sensitivity and high sample throughput for large-scale quantification of hundreds of target proteins are discussed. PMID:27302376

77 FR 189 - Federal Acquisition Regulation; Brand-Name Specifications

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-03

... 2006-0020, Sequence 26] RIN 9000-AK55 Federal Acquisition Regulation; Brand-Name Specifications... changes, the interim rule amending the Federal Acquisition Regulation (FAR) to implement the Office of... for Acquisitions Pursuant to Multiple-Award Contracts, enabled the Civilian Agency Acquisition Council...

48 CFR 32.003 - Simplified acquisition procedures financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... procedures financing. 32.003 Section 32.003 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 32.003 Simplified acquisition procedures financing. Unless agency regulations otherwise permit, contract financing shall not be provided for...

48 CFR 23.103 - Sustainable acquisitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Sustainable Acquisition Policy 23.103 Sustainable acquisitions. (a... the products are— (1) Energy-efficient (ENERGY STAR® or Federal Energy Management Program (FEMP...

48 CFR 1552.232-74 - Payments-simplified acquisition procedures financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... acquisition procedures financing. 1552.232-74 Section 1552.232-74 Federal Acquisition Regulations System... Provisions and Clauses 1552.232-74 Payments—simplified acquisition procedures financing. As prescribed in... acquisition procedures financing. Payments—Simplified Acquisition Procedures Financing (JUN 2006) Simplified...

Reliable Acquisition of RAM Dumps from Intel-Based Apple Mac Computers over FireWire

NASA Astrophysics Data System (ADS)

Gladyshev, Pavel; Almansoori, Afrah

RAM content acquisition is an important step in live forensic analysis of computer systems. FireWire offers an attractive way to acquire RAM content of Apple Mac computers equipped with a FireWire connection. However, the existing techniques for doing so require substantial knowledge of the target computer configuration and cannot be used reliably on a previously unknown computer in a crime scene. This paper proposes a novel method for acquiring RAM content of Apple Mac computers over FireWire, which automatically discovers necessary information about the target computer and can be used in the crime scene setting. As an application of the developed method, the techniques for recovery of AOL Instant Messenger (AIM) conversation fragments from RAM dumps are also discussed in this paper.

Mergers + acquisitions.

PubMed

Hoppszallern, Suzanna

2002-05-01

The hospital sector in 2001 led the health care field in mergers and acquisitions. Most deals involved a network augmenting its presence within a specific region or in a market adjacent to its primary service area. Analysts expect M&A activity to increase in 2002.

48 CFR 1532.003 - Simplified acquisition procedures financing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Simplified acquisition procedures financing. 1532.003 Section 1532.003 Federal Acquisition Regulations System ENVIRONMENTAL.... (c) Procedures for purchases exceeding micropurchase threshold. Contracting officers must secure...

48 CFR 1532.003 - Simplified acquisition procedures financing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Simplified acquisition procedures financing. 1532.003 Section 1532.003 Federal Acquisition Regulations System ENVIRONMENTAL.... (c) Procedures for purchases exceeding micropurchase threshold. Contracting officers must secure...

48 CFR 1532.003 - Simplified acquisition procedures financing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Simplified acquisition procedures financing. 1532.003 Section 1532.003 Federal Acquisition Regulations System ENVIRONMENTAL.... (c) Procedures for purchases exceeding micropurchase threshold. Contracting officers must secure...

48 CFR 1532.003 - Simplified acquisition procedures financing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Simplified acquisition procedures financing. 1532.003 Section 1532.003 Federal Acquisition Regulations System ENVIRONMENTAL.... (c) Procedures for purchases exceeding micropurchase threshold. Contracting officers must secure...

Combined Acquisition/Processing For Data Reduction

NASA Astrophysics Data System (ADS)

Kruger, Robert A.

1982-01-01

Digital image processing systems necessarily consist of three components: acquisition, storage/retrieval and processing. The acquisition component requires the greatest data handling rates. By coupling together the acquisition witn some online hardwired processing, data rates and capacities for short term storage can be reduced. Furthermore, long term storage requirements can be reduced further by appropriate processing and editing of image data contained in short term memory. The net result could be reduced performance requirements for mass storage, processing and communication systems. Reduced amounts of data also snouid speed later data analysis and diagnostic decision making.

48 CFR 970.2301 - Sustainable acquisition.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition...

48 CFR 970.2301 - Sustainable acquisition.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition. ...

48 CFR 23.103 - Sustainable acquisitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Sustainable Acquisition Policy 23.103 Sustainable acquisitions. (a... the products are— (1) Energy-efficient (ENERGY STAR ® or Federal Energy Management Program (FEMP...

48 CFR 970.2301 - Sustainable acquisition.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition. ...

48 CFR 970.2301 - Sustainable acquisition.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition. ...

48 CFR 970.2301 - Sustainable acquisition.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition. ...

48 CFR 208.7403 - Acquisition procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SYSTEM, DEPARTMENT OF DEFENSE ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Enterprise Software Agreements 208.7403 Acquisition procedures. Follow the procedures at PGI 208.7403 when acquiring commercial software and related services. [71 FR 39005, July 11, 2006] ...

Review of Current Aided/Automatic Target Acquisition Technology for Military Target Acquisition Tasks

DTIC Science & Technology

2011-07-01

radar [e.g., synthetic aperture radar (SAR)]. EO/IR includes multi- and hyperspectral imaging. Signal processing of data from nonimaging sensors, such...enhanced recognition ability. Other nonimage -based techniques, such as category theory,45 hierarchical systems,46 and gradient index flow,47 are possible...the battle- field. There is a plethora of imaging and nonimaging sensors on the battlefield that are being networked together for trans- mission of

48 CFR 1480.102 - Buy Indian Act acquisition regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Buy Indian Act acquisition... INDIAN AFFAIRS SUPPLEMENT ACQUISITIONS UNDER THE BUY INDIAN ACT General 1480.102 Buy Indian Act... Interior Acquisition Regulation (DIAR) requirements to satisfy the needs of Indian Affairs in implementing...

Limitations of contrast enhancement for infrared target identification

NASA Astrophysics Data System (ADS)

Du Bosq, Todd W.; Fanning, Jonathan D.

2009-05-01

Contrast enhancement and dynamic range compression are currently being used to improve the performance of infrared imagers by increasing the contrast between the target and the scene content. Automatic contrast enhancement techniques do not always achieve this improvement. In some cases, the contrast can increase to a level of target saturation. This paper assesses the range-performance effects of contrast enhancement for target identification as a function of image saturation. Human perception experiments were performed to determine field performance using contrast enhancement on the U.S. Army RDECOM CERDEC NVESD standard military eight target set using an un-cooled LWIR camera. The experiments compare the identification performance of observers viewing contrast enhancement processed images at various levels of saturation. Contrast enhancement is modeled in the U.S. Army thermal target acquisition model (NVThermIP) by changing the scene contrast temperature. The model predicts improved performance based on any improved target contrast, regardless of specific feature saturation or enhancement. The measured results follow the predicted performance based on the target task difficulty metric used in NVThermIP for the non-saturated cases. The saturated images reduce the information contained in the target and performance suffers. The model treats the contrast of the target as uniform over spatial frequency. As the contrast is enhanced, the model assumes that the contrast is enhanced uniformly over the spatial frequencies. After saturation, the spatial cues that differentiate one tank from another are located in a limited band of spatial frequencies. A frequency dependent treatment of target contrast is needed to predict performance of over-processed images.

The Defense Systems Acquisition and Review Council

DTIC Science & Technology

1976-09-15

THE DEFENSE SYSTEMS ACQUISITION AND REVIEW COUNCIL.. A Study of Areas of Consideration Affecting the Functions and Process of Defense Major...COUNfIL: 4 Study of Areas of Considerationi Affecting/he Functions and Process of Defense _- 1 Major Systems Acquisition. , ; O,. v AUTHOR(e) I. C...Studies DSARC -- Functions and Process OSDCAIG *, Army Systems . A - =A -- he Defense Systems Acquisition Review Council (DSARC) was created to assume

10 CFR 490.302 - Vehicle acquisition mandate schedule.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Vehicle acquisition mandate schedule. 490.302 Section 490.302 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.302 Vehicle acquisition mandate schedule. (a...

10 CFR 490.305 - Acquisitions satisfying the mandate.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Acquisitions satisfying the mandate. 490.305 Section 490.305 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.305 Acquisitions satisfying the mandate. The...

10 CFR 490.302 - Vehicle acquisition mandate schedule.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Vehicle acquisition mandate schedule. 490.302 Section 490.302 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.302 Vehicle acquisition mandate schedule. (a...

10 CFR 490.305 - Acquisitions satisfying the mandate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Acquisitions satisfying the mandate. 490.305 Section 490.305 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.305 Acquisitions satisfying the mandate. The...

10 CFR 490.305 - Acquisitions satisfying the mandate.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Acquisitions satisfying the mandate. 490.305 Section 490.305 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.305 Acquisitions satisfying the mandate. The...

10 CFR 490.305 - Acquisitions satisfying the mandate.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Acquisitions satisfying the mandate. 490.305 Section 490.305 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.305 Acquisitions satisfying the mandate. The...

10 CFR 490.302 - Vehicle acquisition mandate schedule.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Vehicle acquisition mandate schedule. 490.302 Section 490.302 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.302 Vehicle acquisition mandate schedule. (a...

10 CFR 490.302 - Vehicle acquisition mandate schedule.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Vehicle acquisition mandate schedule. 490.302 Section 490.302 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.302 Vehicle acquisition mandate schedule. (a...

10 CFR 490.302 - Vehicle acquisition mandate schedule.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Vehicle acquisition mandate schedule. 490.302 Section 490.302 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fuel Provider Vehicle Acquisition Mandate § 490.302 Vehicle acquisition mandate schedule. (a...

Alternatives to an extended Kalman Filter for target image tracking

NASA Astrophysics Data System (ADS)

Leuthauser, P. R.

1981-12-01

Four alternative filters are compared to an extended Kalman filter (EKF) algorithm for tracking a distributed (elliptical) source target in a closed loop tracking problem, using outputs from a forward looking (FLIR) sensor as measurements. These were (1) an EKF with (second order) bias correction term, (2) a constant gain EKF, (3) a constant gain EKF with bias correction term, and (4) a statistically linearized filter. Estimates are made of both actual target motion and of apparent motion due to atmospheric jitter. These alternative designs are considered specifically to address some of the significant biases exhibited by an EKF due to initial acquisition difficulties, unmodelled maneuvering by the target, low signal-to-noise ratio, and real world conditions varying significantly from those assumed in the filter design (robustness). Filter performance was determined with a Monte Carlo study under both ideal and non ideal conditions for tracking targets on a constant velocity cross range path, and during constant acceleration turns of 5G, 10G, and 20G.

Using Simultaneous Prompting to Teach Restaurant Words and Classifications as Non-Target Information to Secondary Students with Moderate to Severe Disabilities

ERIC Educational Resources Information Center

Smith, Bethany R.; Schuster, John W.; Collins, Belva; Kleinert, Harold

2011-01-01

This paper reviews selected literature pertaining to simultaneous prompting and the acquisition of non-target information for individuals with moderate to severe disabilities. The purpose of this review was to discuss the definition of non-target information (NTI) and the various places it can be embedded within an instructional trial. The…

48 CFR 952.217-70 - Acquisition of real property.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Acquisition of real... Acquisition of real property. Insert the following clause when required by 917.7403: Acquisition of Real... proposes to acquire use of real property by: (1) Purchase, on the Government's behalf or in the Contractor...

48 CFR 952.217-70 - Acquisition of real property.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Acquisition of real... Acquisition of real property. Insert the following clause when required by 917.7403: Acquisition of Real... proposes to acquire use of real property by: (1) Purchase, on the Government's behalf or in the Contractor...

48 CFR 952.217-70 - Acquisition of real property.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Acquisition of real... Acquisition of real property. Insert the following clause when required by 917.7403: Acquisition of Real... proposes to acquire use of real property by: (1) Purchase, on the Government's behalf or in the Contractor...

48 CFR 952.217-70 - Acquisition of real property.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Acquisition of real... Acquisition of real property. Insert the following clause when required by 917.7403: Acquisition of Real... proposes to acquire use of real property by: (1) Purchase, on the Government's behalf or in the Contractor...

48 CFR 952.217-70 - Acquisition of real property.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition of real... Acquisition of real property. Insert the following clause when required by 917.7403: Acquisition of Real... proposes to acquire use of real property by: (1) Purchase, on the Government's behalf or in the Contractor...

Infrared variation reduction by simultaneous background suppression and target contrast enhancement for deep convolutional neural network-based automatic target recognition

NASA Astrophysics Data System (ADS)

Kim, Sungho

2017-06-01

Automatic target recognition (ATR) is a traditionally challenging problem in military applications because of the wide range of infrared (IR) image variations and the limited number of training images. IR variations are caused by various three-dimensional target poses, noncooperative weather conditions (fog and rain), and difficult target acquisition environments. Recently, deep convolutional neural network-based approaches for RGB images (RGB-CNN) showed breakthrough performance in computer vision problems, such as object detection and classification. The direct use of RGB-CNN to the IR ATR problem fails to work because of the IR database problems (limited database size and IR image variations). An IR variation-reduced deep CNN (IVR-CNN) to cope with the problems is presented. The problem of limited IR database size is solved by a commercial thermal simulator (OKTAL-SE). The second problem of IR variations is mitigated by the proposed shifted ramp function-based intensity transformation. This can suppress the background and enhance the target contrast simultaneously. The experimental results on the synthesized IR images generated by the thermal simulator (OKTAL-SE) validated the feasibility of IVR-CNN for military ATR applications.

Processes Asunder: Acquisition & Planning Misfits

DTIC Science & Technology

2009-03-26

Establishing six Business Enterprise Priorities ( BEPs ) to focus the Department’s business transformation efforts, which now guide DoD investment decisions...three phases which look very much like Milestone A, B, and C of the previously existing Life Cycle Management Framework . With this obvious redundancy...February 2002). 30 6 Defense Acquisition University, “Integrated Defense Acquisition, Technology, & Logistics Life Cycle Management Framework , version 5.2

48 CFR 1845.7101-3 - Unit acquisition cost.

Code of Federal Regulations, 2010 CFR

2010-10-01

... services for designs, plans, specifications, and surveys. (6) Acquisition and preparation costs of... acquisition cost is under $100,000, it shall be reported as under $100,000. (g) Software acquisition costs include software costs incurred up through acceptance testing and material internal costs incurred to...

TARGET: Rapid Capture of Process Knowledge

NASA Technical Reports Server (NTRS)

Ortiz, C. J.; Ly, H. V.; Saito, T.; Loftin, R. B.

1993-01-01

TARGET (Task Analysis/Rule Generation Tool) represents a new breed of tool that blends graphical process flow modeling capabilities with the function of a top-down reporting facility. Since NASA personnel frequently perform tasks that are primarily procedural in nature, TARGET models mission or task procedures and generates hierarchical reports as part of the process capture and analysis effort. Historically, capturing knowledge has proven to be one of the greatest barriers to the development of intelligent systems. Current practice generally requires lengthy interactions between the expert whose knowledge is to be captured and the knowledge engineer whose responsibility is to acquire and represent the expert's knowledge in a useful form. Although much research has been devoted to the development of methodologies and computer software to aid in the capture and representation of some types of knowledge, procedural knowledge has received relatively little attention. In essence, TARGET is one of the first tools of its kind, commercial or institutional, that is designed to support this type of knowledge capture undertaking. This paper will describe the design and development of TARGET for the acquisition and representation of procedural knowledge. The strategies employed by TARGET to support use by knowledge engineers, subject matter experts, programmers and managers will be discussed. This discussion includes the method by which the tool employs its graphical user interface to generate a task hierarchy report. Next, the approach to generate production rules for incorporation in and development of a CLIPS based expert system will be elaborated. TARGET also permits experts to visually describe procedural tasks as a common medium for knowledge refinement by the expert community and knowledge engineer making knowledge consensus possible. The paper briefly touches on the verification and validation issues facing the CLIPS rule generation aspects of TARGET. A description of

Positron Emission Mammography with Multiple Angle Acquisition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mark F. Smith; Stan Majewski; Raymond R. Raylman

2002-11-01

Positron emission mammography (PEM) of F-18 fluorodeoxyglucose (FbG) uptake in breast tumors with dedicated detectors typically has been accomplished with two planar detectors in a fixed position with the breast under compression. The potential use of PEM imaging at two detector positions to guide stereotactic breast biopsy has motivated us to use PEM coincidence data acquired at two or more detector positions together in a single image reconstruction. Multiple angle PEM acquisition and iterative image reconstruction were investigated using point source and compressed breast phantom acquisitions with 5, 9, 12 and 15 mm diameter spheres and a simulated tumor:background activitymore » concentration ratio of 6:1. Image reconstruction was performed with an iterative MLEM algorithm that used coincidence events between any two detector pixels on opposed detector heads at each detector position. This present study compared two acquisition protocols: 2 angle acquisition with detector angular positions of -15 and +15 degrees and 11 angle acquisition with detector positions spaced at 3 degree increments over the range -15 to +15 degrees. Three-dimensional image resolution was assessed for the point source acquisitions, and contrast and signal-to-noise metrics were evaluated for the compressed breast phantom with different simulated tumor sizes. Radial and tangential resolutions were similar for the two protocols, while normal resolution was better for the 2 angle acquisition. Analysis is complicated by the asymmetric point spread functions. Signal- to-noise vs. contrast tradeoffs were better for 11 angle acquisition for the smallest visible 9 mm sphere, while tradeoff results were mixed for the larger and more easily visible 12 mm and 15 mm diameter spheres. Additional study is needed to better understand the performance of limited angle tomography for PEM. PEM tomography experiments with complete angular sampling are planned.« less

Predictors of chain acquisition among independent dialysis facilities.

PubMed

Pozniak, Alyssa S; Hirth, Richard A; Banaszak-Holl, Jane; Wheeler, John R C

2010-04-01

To determine the predictors of chain acquisition among independent dialysis providers. Retrospective facility-level data combined from CMS Cost Reports, Medical Evidence Forms, Annual Facility Surveys, and claims for 1996-2003. Independent dialysis facilities' probability of acquisition by a dialysis chain (overall and by chain size) was estimated using a discrete time hazard rate model, controlling for financial and clinical performance, practice patterns, market factors, and other facility characteristics. The sample includes all U.S. freestanding dialysis facilities that report not being chain affiliated for at least 1 year between 1997 and 2003. Above-average costs and better quality outcomes are significant determinants of dialysis chain acquisition. Facilities in larger markets were more likely to be acquired by a chain. Furthermore, small dialysis chains have different acquisition strategies than large chains. Dialysis chains appear to employ a mix of turn-around and cream-skimming strategies. Poor financial health is a predictor of chain acquisition as in other health care sectors, but the increased likelihood of chain acquisition among higher quality facilities is unique to the dialysis industry. Significant differences among predictors of acquisition by small and large chains reinforce the importance of using a richer classification for chain status.

48 CFR 1034.004 - Acquisition strategy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Order, Task Order, or Interagency Agreement) to the overall investment requirements and management... investment; (3) A description of the effort, by acquisition, and the plans to include required clauses in the... requirements to manage the acquisition processes through the investment lifecycle; (7) Consideration of optimal...

Survey identifies trends in equipment acquisitions.

PubMed

Anderson, H J

1990-09-20

Automated laboratory equipment, medical imaging equipment, and patient monitors top the list of hospitals' priorities for equipment acquisition during the next year. This is according to an exclusive survey sponsored by the Linc Group, Inc., Chicago, and Hospitals magazine. The new survey also found that equipment acquisitions are most often financed with internal funds and gifts; that equipment purchasing budgets are on the rise; and that executives believe that most equipment makes money for their hospitals. Find out what your peers have to say about anticipated trends in equipment acquisition and financing during the next year.

Societal Responses to Adult Difficulties in L2 Acquisition: Toward an Evolutionary Perspective on Language Acquisition

ERIC Educational Resources Information Center

Schumann, John H.

2013-01-01

It is generally accepted that second language (L2) acquisition becomes more difficult as one grows older and that success in adult L2 acquisition is highly variable. Nevertheless, humans in language contact situations have to cope with intergroup communication. This article examines the ways society has responded to this challenge. It describes…

Child Language Acquisition: Contrasting Theoretical Approaches

ERIC Educational Resources Information Center

Ambridge, Ben; Lieven, Elena V. M.

2011-01-01

Is children's language acquisition based on innate linguistic structures or built from cognitive and communicative skills? This book summarises the major theoretical debates in all of the core domains of child language acquisition research (phonology, word-learning, inflectional morphology, syntax and binding) and includes a complete introduction…

Motion prediction of a non-cooperative space target

NASA Astrophysics Data System (ADS)

Zhou, Bang-Zhao; Cai, Guo-Ping; Liu, Yun-Meng; Liu, Pan

2018-01-01

Capturing a non-cooperative space target is a tremendously challenging research topic. Effective acquisition of motion information of the space target is the premise to realize target capture. In this paper, motion prediction of a free-floating non-cooperative target in space is studied and a motion prediction algorithm is proposed. In order to predict the motion of the free-floating non-cooperative target, dynamic parameters of the target must be firstly identified (estimated), such as inertia, angular momentum and kinetic energy and so on; then the predicted motion of the target can be acquired by substituting these identified parameters into the Euler's equations of the target. Accurate prediction needs precise identification. This paper presents an effective method to identify these dynamic parameters of a free-floating non-cooperative target. This method is based on two steps, (1) the rough estimation of the parameters is computed using the motion observation data to the target, and (2) the best estimation of the parameters is found by an optimization method. In the optimization problem, the objective function is based on the difference between the observed and the predicted motion, and the interior-point method (IPM) is chosen as the optimization algorithm, which starts at the rough estimate obtained in the first step and finds a global minimum to the objective function with the guidance of objective function's gradient. So the speed of IPM searching for the global minimum is fast, and an accurate identification can be obtained in time. The numerical results show that the proposed motion prediction algorithm is able to predict the motion of the target.

Acquisition by Processing Theory: A Theory of Everything?

ERIC Educational Resources Information Center

Carroll, Susanne E.

2004-01-01

Truscott and Sharwood Smith (henceforth T&SS) propose a novel theory of language acquisition, "Acquisition by Processing Theory" (APT), designed to account for both first and second language acquisition, monolingual and bilingual speech perception and parsing, and speech production. This is a tall order. Like any theoretically ambitious…

75 FR 82576 - Federal Acquisition Regulation; Terminating Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... Acquisition Council (Councils) agree. The language at FAR 49.501, pertaining to the applicability of FAR part...-AL56 Federal Acquisition Regulation; Terminating Contracts AGENCY: Department of Defense (DoD), General.... SUMMARY: DoD, GSA, and NASA are issuing a final rule amending the Federal Acquisition Regulation (FAR) to...

48 CFR 225.7303 - Pricing acquisitions for FMS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing acquisitions for... Military Sales 225.7303 Pricing acquisitions for FMS. (a) Price FMS contracts using the same principles used in pricing other defense contracts. However, application of the pricing principles in FAR parts 15...

48 CFR 53.212 - Acquisition of commercial items.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Acquisition of commercial... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.212 Acquisition of commercial items. SF 1449 (Rev. 3/2005), Solicitation/Contract/Order for Commercial Items. SF 1449 is prescribed for use in...

Pricise Target Geolocation and Tracking Based on Uav Video Imagery

NASA Astrophysics Data System (ADS)

Hosseinpoor, H. R.; Samadzadegan, F.; Dadrasjavan, F.

2016-06-01

There is an increasingly large number of applications for Unmanned Aerial Vehicles (UAVs) from monitoring, mapping and target geolocation. However, most of commercial UAVs are equipped with low-cost navigation sensors such as C/A code GPS and a low-cost IMU on board, allowing a positioning accuracy of 5 to 10 meters. This low accuracy cannot be used in applications that require high precision data on cm-level. This paper presents a precise process for geolocation of ground targets based on thermal video imagery acquired by small UAV equipped with RTK GPS. The geolocation data is filtered using an extended Kalman filter, which provides a smoothed estimate of target location and target velocity. The accurate geo-locating of targets during image acquisition is conducted via traditional photogrammetric bundle adjustment equations using accurate exterior parameters achieved by on board IMU and RTK GPS sensors, Kalman filtering and interior orientation parameters of thermal camera from pre-flight laboratory calibration process. The results of this study compared with code-based ordinary GPS, indicate that RTK observation with proposed method shows more than 10 times improvement of accuracy in target geolocation.

Peruvian Weapon System Acquisition Process

DTIC Science & Technology

1990-12-01

East bloc nations such as Rumania, Bulgaria, Poland, and Yugoslavia essentially retained all or much of their command economies. As these nations foray...The level of technology transfer is an absolut* essential determent for dictating the rate and complexity of Peruvian technologia advancement in the...cases greater than the acquisition cost, it is essential that such costs be considered in development and acquisition decisions in order that proper

Acquisition and tracking for underwater optical communications

NASA Astrophysics Data System (ADS)

Williams, Andrew J.; Laycock, Leslie L.; Griffith, Michael S.; McCarthy, Andrew G.; Rowe, Duncan P.

2017-10-01

There is a growing requirement to transfer large volumes of data between underwater platforms. As seawater is transmissive in the visible band, underwater optical communications is an active area of interest since it offers the potential for power efficient, covert and high bandwidth datalinks at short to medium ranges. Short range systems have been successfully demonstrated using sources with low directionality. To realise higher data rates and/or longer ranges, the use of more efficient directional beams is required; by necessity, these must be sufficiently aligned to achieve the required link margin. For mobile platforms, the acquisition and tracking of each node is therefore critical in order to establish and maintain an optical datalink. This paper describes work undertaken to demonstrate acquisition and tracking in a 3D underwater environment. A range of optical sources, beam steering technologies, and tracking sensors have been assessed for suitability. A novel scanning strategy exploiting variable beam divergence was developed to provide robust acquisition whilst minimising acquisition time. A prototype system was assembled and demonstrated in a large water tank. This utilised custom quadrant detectors based on Silicon PhotoMultiplier (SiPM) arrays for fine tracking, and a Wide Field of View (WFoV) sCMOS camera for link acquisition. Fluidic lenses provided dynamic control of beam divergence, and AC modulation/filtering enabled background rejection. The system successfully demonstrated robust optical acquisition and tracking between two nodes with only nanowatt received optical powers. The acquisition time was shown to be dependent on the initial conditions and the transmitted optical power.

Soldier-in-the-Loop Target Acquisition Performance Prediction Through 2001: Integration of Perceptual and Cognitive Models

DTIC Science & Technology

2006-07-01

parameters such as motion (e.g., Meitzler, Kistner et al ., 1998), multiple observers (Rotman, 1989), scene obscurants (Rotman, Gordan, & Kowalczyk...1989), clutter (Tidhar et al ., 1994), and multiple targets (Rotman, Gordan, & Kowalczyk, 1989) and selective visual attention2. As such, it is...resolvable cycles, N, of a bar pattern (i.e., a square wave) on a target (Johnson, 1958), or complexity (e.g., Tidhar et al ., 1994). Such metrics

Two Demonstrations with a New Data-Acquisition System

ERIC Educational Resources Information Center

Kraftmakher, Yaakov

2014-01-01

Nowadays, the use of data-acquisition systems in undergraduate laboratories is routine. Many computer-assisted experiments became possible with the PASCO scientific data-acquisition system based on the 750 Interface and DataStudio software. A new data-acquisition system developed by PASCO includes the 850 Universal Interface and Capstone software.…

16 CFR 802.35 - Acquisitions by employee trusts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Acquisitions by employee trusts. 802.35... Acquisitions by employee trusts. An acquisition of voting securities shall be exempt from the notification requirements of the act if: (a) The securities are acquired by a trust that meets the qualifications of section...

Gallium-based anti-infectives: targeting microbial iron-uptake mechanisms.

PubMed

Kelson, Andrew B; Carnevali, Maia; Truong-Le, Vu

2013-10-01

Microbes have evolved elaborate iron-acquisition systems to sequester iron from the host environment using siderophores and heme uptake systems. Gallium(III) is structurally similar to iron(III), except that it cannot be reduced under physiological conditions, therefore gallium has the potential to serve as an iron analog, and thus an anti-microbial. Because Ga(III) can bind to virtually any complex that binds Fe(III), simple gallium salts as well as more complex siderophores and hemes are potential carriers to deliver Ga(III) to the microbes. These gallium complexes represent a new class of anti-infectives that is different in mechanism of action from conventional antibiotics. Simple gallium salts such as gallium nitrate, maltolate, and simple gallium siderophore complexes such as gallium citrate have shown good antibacterial activities. The most studied complex has been gallium citrate, which exhibits broad activity against many Gram negative bacteria at ∼1-5μg/ml MICs, strong biofilm activity, low drug resistance, and efficacy in vivo. Using the structural features of specific siderophore and heme made by pathogenic bacteria and fungi, researchers have begun to evaluate new gallium complexes to target key pathogens. This review will summarize potential iron-acquisition system targets and recent research on gallium-based anti-infectives. Copyright © 2013 Elsevier Ltd. All rights reserved.

Multiplexed, quantitative, and targeted metabolite profiling by LC-MS/MRM.

PubMed

Wei, Ru; Li, Guodong; Seymour, Albert B

2014-01-01

Targeted metabolomics, which focuses on a subset of known metabolites representative of biologically relevant metabolic pathways, is a valuable tool to discover biomarkers and link disease phenotypes to underlying mechanisms or therapeutic modes of action. A key advantage of targeted metabolomics, compared to discovery metabolomics, is its immediate readiness for extracting biological information derived from known metabolites and quantitative measurements. However, simultaneously analyzing hundreds of endogenous metabolites presents a challenge due to their diverse chemical structures and properties. Here we report a method which combines different chromatographic separation conditions, optimal ionization polarities, and the most sensitive triple-quadrupole MS-based data acquisition mode, multiple reaction monitoring (MRM), to quantitatively profile 205 endogenous metabolites in 10 min.

Input and Intake in Language Acquisition

ERIC Educational Resources Information Center

Gagliardi, Ann C.

2012-01-01

This dissertation presents an approach for a productive way forward in the study of language acquisition, sealing the rift between claims of an innate linguistic hypothesis space and powerful domain general statistical inference. This approach breaks language acquisition into its component parts, distinguishing the input in the environment from…

Second Language Acquisition and Universal Grammar.

ERIC Educational Resources Information Center

White, Lydia

1990-01-01

Discusses the motivation for Universal Grammar (UG), as assumed in the principles and parameters framework of generative grammar (Chomsky, 1981), focusing on the logical problem of first-language acquisition and the potential role of UG in second-language acquisition. Recent experimental research regarding the second-language status of the…

48 CFR 225.7003 - Restrictions on acquisition of specialty metals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Restrictions on acquisition of specialty metals. 225.7003 Section 225.7003 Federal Acquisition Regulations System DEFENSE... Restrictions on acquisition of specialty metals. ...

48 CFR 225.7003 - Restrictions on acquisition of specialty metals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions on acquisition of specialty metals. 225.7003 Section 225.7003 Federal Acquisition Regulations System DEFENSE... Restrictions on acquisition of specialty metals. ...

76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System... Federal Acquisition Regulation Supplement (DFARS) to direct contracting officers to additional guidance on...

Advances in targeted proteomics and applications to biomedical research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, Tujin; Song, Ehwang; Nie, Song

Targeted proteomics technique has emerged as a powerful protein quantification tool in systems biology, biomedical research, and increasing for clinical applications. The most widely used targeted proteomics approach, selected reaction monitoring (SRM), also known as multiple reaction monitoring (MRM), can be used for quantification of cellular signaling networks and preclinical verification of candidate protein biomarkers. As an extension to our previous review on advances in SRM sensitivity (Shi et al., Proteomics, 12, 1074–1092, 2012) herein we review recent advances in the method and technology for further enhancing SRM sensitivity (from 2012 to present), and highlighting its broad biomedical applications inmore » human bodily fluids, tissue and cell lines. Furthermore, we also review two recently introduced targeted proteomics approaches, parallel reaction monitoring (PRM) and data-independent acquisition (DIA) with targeted data extraction on fast scanning high-resolution accurate-mass (HR/AM) instruments. Such HR/AM targeted quantification with monitoring all target product ions addresses SRM limitations effectively in specificity and multiplexing; whereas when compared to SRM, PRM and DIA are still in the infancy with a limited number of applications. Thus, for HR/AM targeted quantification we focus our discussion on method development, data processing and analysis, and its advantages and limitations in targeted proteomics. Finally, general perspectives on the potential of achieving both high sensitivity and high sample throughput for large-scale quantification of hundreds of target proteins are discussed.« less

77 FR 13093 - Corrosion-Resistant Carbon Steel Flat Products From the Republic of Korea: Final Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

...-resistant metals such as zinc, aluminum, or zinc-, aluminum-, nickel- or iron-based alloys, whether or not... Special Taxation Act (RSTA) Article 26 II. Programs That Provided No Benefits During the POR A. Research and Development Grants Under the Industrial Development Act (IDA) B. Research and Development Grants...

Predictors of Chain Acquisition among Independent Dialysis Facilities

PubMed Central

Pozniak, Alyssa S; Hirth, Richard A; Banaszak-Holl, Jane; Wheeler, John R C

2010-01-01

Objective To determine the predictors of chain acquisition among independent dialysis providers. Data Sources Retrospective facility-level data combined from CMS Cost Reports, Medical Evidence Forms, Annual Facility Surveys, and claims for 1996–2003. Study Design Independent dialysis facilities' probability of acquisition by a dialysis chain (overall and by chain size) was estimated using a discrete time hazard rate model, controlling for financial and clinical performance, practice patterns, market factors, and other facility characteristics. Data Collection The sample includes all U.S. freestanding dialysis facilities that report not being chain affiliated for at least 1 year between 1997 and 2003. Principal Findings Above-average costs and better quality outcomes are significant determinants of dialysis chain acquisition. Facilities in larger markets were more likely to be acquired by a chain. Furthermore, small dialysis chains have different acquisition strategies than large chains. Conclusions Dialysis chains appear to employ a mix of turn-around and cream-skimming strategies. Poor financial health is a predictor of chain acquisition as in other health care sectors, but the increased likelihood of chain acquisition among higher quality facilities is unique to the dialysis industry. Significant differences among predictors of acquisition by small and large chains reinforce the importance of using a richer classification for chain status. PMID:20148985

Drug spend and acquisitive offending by substance misusers.

PubMed

Hayhurst, Karen P; Jones, Andrew; Millar, Tim; Pierce, Matthias; Davies, Linda; Weston, Samantha; Donmall, Michael

2013-06-01

The need to generate income to fund drug misuse is assumed to be a driver of involvement in acquisitive crime. We examined the influence of drug misuse expenditure, and other factors, on acquisitive offending. Clients (N=1380) seeking drug treatment within 94 of 149 Drug Action Teams (DATs) across England completed a comprehensive survey, incorporating validated scales and self-report measures, such as levels of drug and alcohol use and offending. Forty per cent (N=554) had committed acquisitive crime in the previous month. Regression analysis showed that acquisitive offending was associated with the presence of problematic use of crack cocaine, poly-drug use, sharing injecting equipment, unsafe sex, overdose risk, higher drug spend, unemployment, reduced mental wellbeing, and younger age. Rates of acquisitive crime among drug users are high. Drug using offenders can be distinguished from drug using non-offenders by problematic crack cocaine use, younger age, income-related factors, and indicators of a chaotic life style and complex needs. Behavioural and demographic factors were associated more strongly with acquisitive crime than drug use expenditure, suggesting that the need to finance drug use is not necessarily the main factor driving acquisitive offending by drug users. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

48 CFR 225.7702 - Acquisition of small arms.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Acquisition of small arms... Operations in Iraq or Afghanistan 225.7702 Acquisition of small arms. (a) Except as provided in paragraph (b) of this section, when acquiring small arms for assistance to the Army of Iraq, the Army of...

48 CFR 225.7702 - Acquisition of small arms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of small arms... Operations in Iraq or Afghanistan 225.7702 Acquisition of small arms. (a) Except as provided in paragraph (b) of this section, when acquiring small arms for assistance to the Army of Iraq, the Army of...

48 CFR 225.7702 - Acquisition of small arms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Acquisition of small arms... Operations in Iraq or Afghanistan 225.7702 Acquisition of small arms. (a) Except as provided in paragraph (b) of this section, when acquiring small arms for assistance to the Army of Iraq, the Army of...

75 FR 78619 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 216 and 237 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations... the Defense Federal Acquisition Regulation Supplement (DFARS) to set forth references to supplementary...

Effects of different practice conditions on acquisition, retention, and transfer of soccer skills by 9-year-old schoolchildren.

PubMed

Vera, Juan Granda; Alvarez, José Carlos Barbero; Medina, Mariano Montilla

2008-04-01

This study was designed to examine effects of three practice models, blocked, variable, and combined, on the acquisition, retention, and transfer of new motor skills. 67 subjects (M age = 9.5 yr., SD = .3) from the fourth year of primary school (31 boys and 26 girls) were assigned at random to three different practice groups (Blocked = 22, Variable = 23, Combined = 22) to study acquisition of two skills, dribbling a soccer ball and kicking a soccer ball at a stationary target using the dominant foot. All participants received a pretest and posttest, a transfer test, and a retention test 2 wk. later. Analysis showed significant improvement after practice of kicking skills by the three groups but not in the dribbling skills, for which only the combined practice group showed any notable improvement. At the end of acquisition, the combined practice group had significantly better performance on the dribbling task than the other two groups. However, the only differences noted in performance of kicking the ball with the dominant foot were by combined practice and blocked groups.

A high speed buffer for LV data acquisition

NASA Technical Reports Server (NTRS)

Cavone, Angelo A.; Sterlina, Patrick S.; Clemmons, James I., Jr.; Meyers, James F.

1987-01-01

The laser velocimeter (autocovariance) buffer interface is a data acquisition subsystem designed specifically for the acquisition of data from a laser velocimeter. The subsystem acquires data from up to six laser velocimeter components in parallel, measures the times between successive data points for each of the components, establishes and maintains a coincident condition between any two or three components, and acquires data from other instrumentation systems simultaneously with the laser velocimeter data points. The subsystem is designed to control the entire data acquisition process based on initial setup parameters obtained from a host computer and to be independent of the computer during the acquisition. On completion of the acquisition cycle, the interface transfers the contents of its memory to the host under direction of the host via a single 16-bit parallel DMA channel.

76 FR 39234 - Federal Acquisition Regulation; Unique Procurement Instrument Identifier

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

...-AL70 Federal Acquisition Regulation; Unique Procurement Instrument Identifier AGENCIES: Department of... Acquisition Regulation (FAR) to standardize use of unique Procurement Instrument Identifiers (PIID) throughout... Acquisition Council and the Defense Acquisition Regulations Council (the Councils) reviewed the public...

48 CFR 1401.370 - Acquisition Managers' Partnership.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Acquisition Managers' Partnership. (a) The Acquisition Managers' Partnership (AMP) is a forum for DOI's senior... and effectiveness of its procurement services in support of DOI's mission. (b) The AMP consists of the...

Targeted Delivery of Amoxicillin to C. trachomatis by the Transferrin Iron Acquisition Pathway

PubMed Central

Hai, Jun; Serradji, Nawal; Mouton, Ludovic; Redeker, Virginie; Cornu, David; El Hage Chahine, Jean-Michel

2016-01-01

Weak intracellular penetration of antibiotics makes some infections difficult to treat. The Trojan horse strategy for targeted drug delivery is among the interesting routes being explored to overcome this therapeutic difficulty. Chlamydia trachomatis, as an obligate intracellular human pathogen, is responsible for both trachoma and sexually transmitted diseases. Chlamydia develops in a vacuole and is therefore protected by four membranes (plasma membrane, bacterial inclusion membrane, and bacterial membranes). In this work, the iron-transport protein, human serum-transferrin, was used as a Trojan horse for antibiotic delivery into the bacterial vacuole. Amoxicillin was grafted onto transferrin. The transferrin-amoxicillin construct was characterized by mass spectrometry and absorption spectroscopy. Its affinity for transferrin receptor 1, determined by fluorescence emission titration [KaffTf-amox = (1.3 ± 1.0) x 108], is very close to that of transferrin [4.3 x 108]. Transmission electron and confocal microscopies showed a co-localization of transferrin with the bacteria in the vacuole and were also used to evaluate the antibiotic capability of the construct. It is significantly more effective than amoxicillin alone. These promising results demonstrate targeted delivery of amoxicillin to suppress Chlamydia and are of interest for Chlamydiaceae and maybe other intracellular bacteria therapies. PMID:26919720

Targeted Delivery of Amoxicillin to C. trachomatis by the Transferrin Iron Acquisition Pathway.

PubMed

Hai, Jun; Serradji, Nawal; Mouton, Ludovic; Redeker, Virginie; Cornu, David; El Hage Chahine, Jean-Michel; Verbeke, Philippe; Hémadi, Miryana

2016-01-01

Weak intracellular penetration of antibiotics makes some infections difficult to treat. The Trojan horse strategy for targeted drug delivery is among the interesting routes being explored to overcome this therapeutic difficulty. Chlamydia trachomatis, as an obligate intracellular human pathogen, is responsible for both trachoma and sexually transmitted diseases. Chlamydia develops in a vacuole and is therefore protected by four membranes (plasma membrane, bacterial inclusion membrane, and bacterial membranes). In this work, the iron-transport protein, human serum-transferrin, was used as a Trojan horse for antibiotic delivery into the bacterial vacuole. Amoxicillin was grafted onto transferrin. The transferrin-amoxicillin construct was characterized by mass spectrometry and absorption spectroscopy. Its affinity for transferrin receptor 1, determined by fluorescence emission titration [KaffTf-amox = (1.3 ± 1.0) x 108], is very close to that of transferrin [4.3 x 108]. Transmission electron and confocal microscopies showed a co-localization of transferrin with the bacteria in the vacuole and were also used to evaluate the antibiotic capability of the construct. It is significantly more effective than amoxicillin alone. These promising results demonstrate targeted delivery of amoxicillin to suppress Chlamydia and are of interest for Chlamydiaceae and maybe other intracellular bacteria therapies.

Modulation of phase durations, phase variations, and temporal coordination of the four limbs during quadrupedal split-belt locomotion in intact adult cats

PubMed Central

D'Angelo, Giuseppe; Thibaudier, Yann; Telonio, Alessandro; Hurteau, Marie-France; Kuczynski, Victoria; Dambreville, Charline

2014-01-01

Stepping along curvilinear paths produces speed differences between the inner and outer limb(s). This can be reproduced experimentally by independently controlling left and right speeds with split-belt locomotion. Here we provide additional details on the pattern of the four limbs during quadrupedal split-belt locomotion in intact cats. Six cats performed tied-belt locomotion (same speed bilaterally) and split-belt locomotion where one side (constant side) stepped at constant treadmill speed while the other side (varying side) stepped at several speeds. Cycle, stance, and swing durations changed in parallel in homolateral limbs with shorter and longer stance and swing durations on the fast side, respectively, compared with the slow side. Phase variations were quantified in all four limbs by measuring the slopes of the regressions between stance and cycle durations (rSTA) and between swing and cycle durations (rSW). For a given limb, rSTA and rSW were not significantly different from one another on the constant side whereas on the varying side rSTA increased relative to tied-belt locomotion while rSW became more negative. Phase variations were similar for homolateral limbs. Increasing left-right speed differences produced a large increase in homolateral double support on the slow side, while triple-support periods decreased. Increasing left-right speed differences altered homologous coupling, homolateral coupling on the fast side, and coupling between the fast hindlimb and slow forelimb. Results indicate that homolateral limbs share similar control strategies, only certain features of the interlimb pattern adjust, and spinal locomotor networks of the left and right sides are organized symmetrically. PMID:25031257

7 CFR 1710.107 - Amount lent for acquisitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Amount lent for acquisitions. 1710.107 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.107 Amount lent for acquisitions. The maximum amount that will be lent for an acquisition is limited to the value of the property, as determined by RUS. If the...

Cross-linguistic patterns in the acquisition of quantifiers.

PubMed

Katsos, Napoleon; Cummins, Chris; Ezeizabarrena, Maria-José; Gavarró, Anna; Kuvač Kraljević, Jelena; Hrzica, Gordana; Grohmann, Kleanthes K; Skordi, Athina; Jensen de López, Kristine; Sundahl, Lone; van Hout, Angeliek; Hollebrandse, Bart; Overweg, Jessica; Faber, Myrthe; van Koert, Margreet; Smith, Nafsika; Vija, Maigi; Zupping, Sirli; Kunnari, Sari; Morisseau, Tiffany; Rusieshvili, Manana; Yatsushiro, Kazuko; Fengler, Anja; Varlokosta, Spyridoula; Konstantzou, Katerina; Farby, Shira; Guasti, Maria Teresa; Vernice, Mirta; Okabe, Reiko; Isobe, Miwa; Crosthwaite, Peter; Hong, Yoonjee; Balčiūnienė, Ingrida; Ahmad Nizar, Yanti Marina; Grech, Helen; Gatt, Daniela; Cheong, Win Nee; Asbjørnsen, Arve; Torkildsen, Janne von Koss; Haman, Ewa; Miękisz, Aneta; Gagarina, Natalia; Puzanova, Julia; Anđelković, Darinka; Savić, Maja; Jošić, Smiljana; Slančová, Daniela; Kapalková, Svetlana; Barberán, Tania; Özge, Duygu; Hassan, Saima; Chan, Cecilia Yuet Hung; Okubo, Tomoya; van der Lely, Heather; Sauerland, Uli; Noveck, Ira

2016-08-16

Learners of most languages are faced with the task of acquiring words to talk about number and quantity. Much is known about the order of acquisition of number words as well as the cognitive and perceptual systems and cultural practices that shape it. Substantially less is known about the acquisition of quantifiers. Here, we consider the extent to which systems and practices that support number word acquisition can be applied to quantifier acquisition and conclude that the two domains are largely distinct in this respect. Consequently, we hypothesize that the acquisition of quantifiers is constrained by a set of factors related to each quantifier's specific meaning. We investigate competence with the expressions for "all," "none," "some," "some…not," and "most" in 31 languages, representing 11 language types, by testing 768 5-y-old children and 536 adults. We found a cross-linguistically similar order of acquisition of quantifiers, explicable in terms of four factors relating to their meaning and use. In addition, exploratory analyses reveal that language- and learner-specific factors, such as negative concord and gender, are significant predictors of variation.

An Experiment Quantifying The Effect Of Clutter On Target Detection

NASA Astrophysics Data System (ADS)

Weathersby, Marshall R.; Schmieder, David E.

1985-01-01

Experiments were conducted to determine the influence of background clutter on target detection criteria. The experiment consisted of placing observers in front of displayed images on a TV monitor. Observer ability to detect military targets embedded in simulated natural and manmade background clutter was measured when there was unlimited viewing time. Results were described in terms of detection probability versus target resolution for various signal to clutter ratios (SCR). The experiments were preceded by a search for a meaningful clutter definition. The selected definition was a statistical measure computed by averaging the standard deviation of contiguous scene cells over the whole scene. The cell size was comparable to the target size. Observer test results confirmed the expectation that the resolution required for a given detection probability was a continuum function of the clutter level. At the lower SCRs the resolution required for a high probability of detection was near 6 lines pairs per target (LP/TGT), while at the higher SCRs it was found that a resolution of less than 0.25 LP/TGT would yield a high probability of detection. These results are expected to aid in target acquisition performance modeling and to lead to improved specifications for imaging automatic target screeners.

75 FR 48873 - Acquisition Regulation Rewrite

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-12

... Acquisition Regulation (DIAR). This action revises the DIAR, 48 CFR chapter 14, but does not impose any new..., 2010. No public comments were received. DOI has concluded that the interim rule should be adopted as a... DEPARTMENT OF THE INTERIOR Office of the Secretary 48 CFR Chapter 14 RIN 1093-AA11 Acquisition...

75 FR 60261 - Federal Acquisition Regulation; Award-Fee Language Revision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-29

...-AL42 Federal Acquisition Regulation; Award-Fee Language Revision AGENCIES: Department of Defense (DoD...: Final rule. SUMMARY: The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) have adopted as final, with changes, the interim rule amending the Federal Acquisition...

Post-image acquisition processing approaches for coherent backscatter validation

NASA Astrophysics Data System (ADS)

Smith, Christopher A.; Belichki, Sara B.; Coffaro, Joseph T.; Panich, Michael G.; Andrews, Larry C.; Phillips, Ronald L.

2014-10-01

Utilizing a retro-reflector from a target point, the reflected irradiance of a laser beam traveling back toward the transmitting point contains a peak point of intensity known as the enhanced backscatter (EBS) phenomenon. EBS is dependent on the strength regime of turbulence currently occurring within the atmosphere as the beam propagates across and back. In order to capture and analyze this phenomenon so that it may be compared to theory, an imaging system is integrated into the optical set up. With proper imaging established, we are able to implement various post-image acquisition techniques to help determine detection and positioning of EBS which can then be validated with theory by inspection of certain dependent meteorological parameters such as the refractive index structure parameter, Cn2 and wind speed.

75 FR 14057 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-40; Introduction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-23

...: Introduction, Small Entity Compliance Guide, Federal Awardee Performance and Integrity, Information System...; Federal Acquisition Circular 2005-40; Introduction AGENCIES: Department of Defense (DoD), General Services...

US-Cut: interactive algorithm for rapid detection and segmentation of liver tumors in ultrasound acquisitions

NASA Astrophysics Data System (ADS)

Egger, Jan; Voglreiter, Philip; Dokter, Mark; Hofmann, Michael; Chen, Xiaojun; Zoller, Wolfram G.; Schmalstieg, Dieter; Hann, Alexander

2016-04-01

Ultrasound (US) is the most commonly used liver imaging modality worldwide. It plays an important role in follow-up of cancer patients with liver metastases. We present an interactive segmentation approach for liver tumors in US acquisitions. Due to the low image quality and the low contrast between the tumors and the surrounding tissue in US images, the segmentation is very challenging. Thus, the clinical practice still relies on manual measurement and outlining of the tumors in the US images. We target this problem by applying an interactive segmentation algorithm to the US data, allowing the user to get real-time feedback of the segmentation results. The algorithm has been developed and tested hand-in-hand by physicians and computer scientists to make sure a future practical usage in a clinical setting is feasible. To cover typical acquisitions from the clinical routine, the approach has been evaluated with dozens of datasets where the tumors are hyperechoic (brighter), hypoechoic (darker) or isoechoic (similar) in comparison to the surrounding liver tissue. Due to the interactive real-time behavior of the approach, it was possible even in difficult cases to find satisfying segmentations of the tumors within seconds and without parameter settings, and the average tumor deviation was only 1.4mm compared with manual measurements. However, the long term goal is to ease the volumetric acquisition of liver tumors in order to evaluate for treatment response. Additional aim is the registration of intraoperative US images via the interactive segmentations to the patient's pre-interventional CT acquisitions.

48 CFR 352.215-1 - Instructions to offerors-competitive acquisition.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-competitive acquisition. 352.215-1 Section 352.215-1 Federal Acquisition Regulations System HEALTH AND HUMAN....215-1 Instructions to offerors—competitive acquisition. As prescribed in 315.209, the Contracting... Offerors—Competitive Acquisition: (e) Restriction on disclosure and use of data. (1) The proposal submitted...

Defense Acquisition Workforce: The Air Force Needs to Evaluate Changes in Funding for Civilians Engaged in Space Acquisition

DTIC Science & Technology

2013-07-01

1) revitalize the acquisition workforce; (2) improve the requirements generation process; (3) instill budget and financial DOD Acquisition...with our four recommended actions (see app . I). In concurring with our recommendations, DOD stated that the Air Force will evaluate the pilot program

Buffer Gas Acquisition and Storage

NASA Technical Reports Server (NTRS)

Parrish, Clyde F.; Lueck, Dale E.; Jennings, Paul A.; Callahan, Richard A.; Delgado, H. (Technical Monitor)

2001-01-01

The acquisition and storage of buffer gases (primarily argon and nitrogen) from the Mars atmosphere provides a valuable resource for blanketing and pressurizing fuel tanks and as a buffer gas for breathing air for manned missions. During the acquisition of carbon dioxide (CO2), whether by sorption bed or cryo-freezer, the accompanying buffer gases build up in the carbon dioxide acquisition system, reduce the flow of CO2 to the bed, and lower system efficiency. It is this build up of buffer gases that provide a convenient source, which must be removed, for efficient capture Of CO2 Removal of this buffer gas barrier greatly improves the charging rate of the CO2 acquisition bed and, thereby, maintains the fuel production rates required for a successful mission. Consequently, the acquisition, purification, and storage of these buffer gases are important goals of ISRU plans. Purity of the buffer gases is a concern e.g., if the CO, freezer operates at 140 K, the composition of the inert gas would be approximately 21 percent CO2, 50 percent nitrogen, and 29 percent argon. Although there are several approaches that could be used, this effort focused on a hollow-fiber membrane (HFM) separation method. This study measured the permeation rates of CO2, nitrogen (ND, and argon (Ar) through a multiple-membrane system and the individual membranes from room temperature to 193K and 10 kpa to 300 kPa. Concentrations were measured with a gas chromatograph that used a thermoconductivity (TCD) detector with helium (He) as the carrier gas. The general trend as the temperature was lowered was for the membranes to become more selective, In addition, the relative permeation rates between the three gases changed with temperature. The end result was to provide design parameters that could be used to separate CO2 from N2 and Ar.

Heuristic-based information acquisition and decision making among pilots.

PubMed

Wiggins, Mark W; Bollwerk, Sandra

2006-01-01

This research was designed to examine the impact of heuristic-based approaches to the acquisition of task-related information on the selection of an optimal alternative during simulated in-flight decision making. The work integrated features of naturalistic and normative decision making and strategies of information acquisition within a computer-based, decision support framework. The study comprised two phases, the first of which involved familiarizing pilots with three different heuristic-based strategies of information acquisition: frequency, elimination by aspects, and majority of confirming decisions. The second stage enabled participants to choose one of the three strategies of information acquisition to resolve a fourth (choice) scenario. The results indicated that task-oriented experience, rather than the information acquisition strategies, predicted the selection of the optimal alternative. It was also evident that of the three strategies available, the elimination by aspects information acquisition strategy was preferred by most participants. It was concluded that task-oriented experience, rather than the process of information acquisition, predicted task accuracy during the decision-making task. It was also concluded that pilots have a preference for one particular approach to information acquisition. Applications of outcomes of this research include the development of decision support systems that adapt to the information-processing capabilities and preferences of users.

The Effects of Target Word Properties on the Incidental Acquisition of Vocabulary through Reading

ERIC Educational Resources Information Center

Reynolds, Barry Lee

2016-01-01

The primary aim of this investigation was to determine what combination of target word variables (frequency, patternedness, length, cognateness, lexicalization) could best predict the difficulty of incidentally acquiring vocabulary through reading. A group of adult English First Language (EL1) (n = 20) and adult English as a Foreign Language (EFL)…

Data Acquisition and Real-Time Systems.

ERIC Educational Resources Information Center

Lawrence, D. E., Ed.; Fenwick, P. M., Ed.

The first group of papers starts with a tutorial paper which surveys the methods used in data acquisition systems. Other papers in this group describe: (1) some problems involved in the computer acquisition of high-speed randomly-occurring data and the protection of this data from accidental corruption, (2) an input/output bus to allow an IBM…

Hospital Acquisitions Before Healthcare Reform.

PubMed

McCue, Michael J; Thompson, Jon M; Kim, Tae Hyun

2015-01-01

The hospital industry has experienced increased consolidation in the past 20 years. Since 2010, in particular, there has been a large rise in the number of hospital acquisitions, and observers have suggested this is due in part to the expected impact of federal healthcare reform legislation. This article reports on a study undertaken to identify the market, management, and financial factors affecting acute care, community hospitals acquired between 2010 and 2012. We identified 77 such hospitals and compared them to other acute care facilities. To assess how different factors were associated with acquisitions, the study used multiple logistic regressions whereby market factors were included first, followed by management and financial factors. Study findings show that acquired hospitals were located in markets with lower rates of preferred provider organization (PPO) penetration compared with nonacquired hospitals. Occupancy rate was found to be inversely related to acquisition rate; however, case-mix index was significantly and positively related to a hospital's being acquired. Financial factors negatively associated with a hospital's being acquired included age of plant and cash flow margin. In contrast to the findings from earlier studies of hospital acquisitions, our results showed that acquired hospitals possessed newer assets. However, similar to the findings of other studies, the cash flow margin of acquired hospitals was lower than that of nonacquired facilities.

48 CFR 939.7002 - Contractor acquisition of information technology.

Code of Federal Regulations, 2013 CFR

2013-10-01

... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating (M&O...

48 CFR 939.7002 - Contractor acquisition of information technology.

Code of Federal Regulations, 2014 CFR

2014-10-01

... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating (M&O...

48 CFR 939.7002 - Contractor acquisition of information technology.

Code of Federal Regulations, 2011 CFR

2011-10-01

... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating (M&O...

48 CFR 939.7002 - Contractor acquisition of information technology.

Code of Federal Regulations, 2012 CFR

2012-10-01

... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating (M&O...

48 CFR 939.7002 - Contractor acquisition of information technology.

Code of Federal Regulations, 2010 CFR

2010-10-01

... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating (M&O...

48 CFR 1.102-4 - Role of the acquisition team.

Code of Federal Regulations, 2011 CFR

2011-10-01

... team. 1.102-4 Section 1.102-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... acquisition team. (a) Government members of the Team must be empowered to make acquisition decisions within...) The Team must be prepared to perform the functions and duties assigned. The Government is committed to...

48 CFR 1.102-4 - Role of the acquisition team.

Code of Federal Regulations, 2012 CFR

2012-10-01

... team. 1.102-4 Section 1.102-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... acquisition team. (a) Government members of the Team must be empowered to make acquisition decisions within...) The Team must be prepared to perform the functions and duties assigned. The Government is committed to...

48 CFR 1.102-4 - Role of the acquisition team.

Code of Federal Regulations, 2013 CFR

2013-10-01

... team. 1.102-4 Section 1.102-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... acquisition team. (a) Government members of the Team must be empowered to make acquisition decisions within...) The Team must be prepared to perform the functions and duties assigned. The Government is committed to...

48 CFR 1.102-4 - Role of the acquisition team.

Code of Federal Regulations, 2010 CFR

2010-10-01

... team. 1.102-4 Section 1.102-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... acquisition team. (a) Government members of the Team must be empowered to make acquisition decisions within...) The Team must be prepared to perform the functions and duties assigned. The Government is committed to...

48 CFR 1.102-4 - Role of the acquisition team.

Code of Federal Regulations, 2014 CFR

2014-10-01

... team. 1.102-4 Section 1.102-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... acquisition team. (a) Government members of the Team must be empowered to make acquisition decisions within...) The Team must be prepared to perform the functions and duties assigned. The Government is committed to...

Handgun Acquisitions in California After Two Mass Shootings.

PubMed

Studdert, David M; Zhang, Yifan; Rodden, Jonathan A; Hyndman, Rob J; Wintemute, Garen J

2017-05-16

Mass shootings are common in the United States. They are the most visible form of firearm violence. Their effect on personal decisions to purchase firearms is not well-understood. To determine changes in handgun acquisition patterns after the mass shootings in Newtown, Connecticut, in 2012 and San Bernardino, California, in 2015. Time-series analysis using seasonal autoregressive integrated moving-average (SARIMA) models. California. Adults who acquired handguns between 2007 and 2016. Excess handgun acquisitions (defined as the difference between actual and expected acquisitions) in the 6-week and 12-week periods after each shooting, overall and within subgroups of acquirers. In the 6 weeks after the Newtown and San Bernardino shootings, there were 25 705 (95% prediction interval, 17 411 to 32 788) and 27 413 (prediction interval, 15 188 to 37 734) excess acquisitions, respectively, representing increases of 53% (95% CI, 30% to 80%) and 41% (CI, 19% to 68%) over expected volume. Large increases in acquisitions occurred among white and Hispanic persons, but not among black persons, and among persons with no record of having previously acquired a handgun. After the San Bernardino shootings, acquisition rates increased by 85% among residents of that city and adjacent neighborhoods, compared with 35% elsewhere in California. The data relate to handguns in 1 state. The statistical analysis cannot establish causality. Large increases in handgun acquisitions occurred after these 2 mass shootings. The spikes were short-lived and accounted for less than 10% of annual handgun acquisitions statewide. Further research should examine whether repeated shocks of this kind lead to substantial increases in the prevalence of firearm ownership. None.

Acquisition management of the Global Transportation Network

DOT National Transportation Integrated Search

2001-08-02

This report discusses the acquisition management of the Global transportation Network by the U.S. Transportation Command. This report is one in a series of audit reports addressing DoD acquisition management of information technology systems. The Glo...

AZ-101 Mixer Pump Demonstration Data Acquisition System and Gamma Cart Data Acquisition Control System Software Configuration Management Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

WHITE, D.A.

1999-12-29

This Software Configuration Management Plan (SCMP) provides the instructions for change control of the AZ1101 Mixer Pump Demonstration Data Acquisition System (DAS) and the Sludge Mobilization Cart (Gamma Cart) Data Acquisition and Control System (DACS).

Cross-linguistic patterns in the acquisition of quantifiers

PubMed Central

Cummins, Chris; Gavarró, Anna; Kuvač Kraljević, Jelena; Hrzica, Gordana; Grohmann, Kleanthes K.; Skordi, Athina; Jensen de López, Kristine; Sundahl, Lone; van Hout, Angeliek; Hollebrandse, Bart; Overweg, Jessica; Faber, Myrthe; van Koert, Margreet; Smith, Nafsika; Vija, Maigi; Zupping, Sirli; Kunnari, Sari; Morisseau, Tiffany; Rusieshvili, Manana; Yatsushiro, Kazuko; Fengler, Anja; Varlokosta, Spyridoula; Konstantzou, Katerina; Farby, Shira; Guasti, Maria Teresa; Vernice, Mirta; Okabe, Reiko; Isobe, Miwa; Crosthwaite, Peter; Hong, Yoonjee; Balčiūnienė, Ingrida; Ahmad Nizar, Yanti Marina; Grech, Helen; Gatt, Daniela; Cheong, Win Nee; Asbjørnsen, Arve; Torkildsen, Janne von Koss; Haman, Ewa; Miękisz, Aneta; Gagarina, Natalia; Puzanova, Julia; Anđelković, Darinka; Savić, Maja; Jošić, Smiljana; Slančová, Daniela; Kapalková, Svetlana; Barberán, Tania; Özge, Duygu; Hassan, Saima; Chan, Cecilia Yuet Hung; Okubo, Tomoya; van der Lely, Heather; Sauerland, Uli; Noveck, Ira

2016-01-01

Learners of most languages are faced with the task of acquiring words to talk about number and quantity. Much is known about the order of acquisition of number words as well as the cognitive and perceptual systems and cultural practices that shape it. Substantially less is known about the acquisition of quantifiers. Here, we consider the extent to which systems and practices that support number word acquisition can be applied to quantifier acquisition and conclude that the two domains are largely distinct in this respect. Consequently, we hypothesize that the acquisition of quantifiers is constrained by a set of factors related to each quantifier’s specific meaning. We investigate competence with the expressions for “all,” “none,” “some,” “some…not,” and “most” in 31 languages, representing 11 language types, by testing 768 5-y-old children and 536 adults. We found a cross-linguistically similar order of acquisition of quantifiers, explicable in terms of four factors relating to their meaning and use. In addition, exploratory analyses reveal that language- and learner-specific factors, such as negative concord and gender, are significant predictors of variation. PMID:27482119

Two-dimensional hidden semantic information model for target saliency detection and eyetracking identification

NASA Astrophysics Data System (ADS)

Wan, Weibing; Yuan, Lingfeng; Zhao, Qunfei; Fang, Tao

2018-01-01

Saliency detection has been applied to the target acquisition case. This paper proposes a two-dimensional hidden Markov model (2D-HMM) that exploits the hidden semantic information of an image to detect its salient regions. A spatial pyramid histogram of oriented gradient descriptors is used to extract features. After encoding the image by a learned dictionary, the 2D-Viterbi algorithm is applied to infer the saliency map. This model can predict fixation of the targets and further creates robust and effective depictions of the targets' change in posture and viewpoint. To validate the model with a human visual search mechanism, two eyetrack experiments are employed to train our model directly from eye movement data. The results show that our model achieves better performance than visual attention. Moreover, it indicates the plausibility of utilizing visual track data to identify targets.

Developing Program Management Leadership for Acquisition Reform

DTIC Science & Technology

2011-04-30

mêçÅÉÉÇáåÖë= çÑ=íÜÉ= bfdeqe=^kkr^i=^`nrfpfqflk== obpb^o`e=pvjmlpfrj== qeropa^v=pbppflkp== slirjb ff Developing Program Management Leadership for...4. TITLE AND SUBTITLE Developing Program Management Leadership for Acquisition Reform 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...Developing Program  Management   Leadership   for Acquisition Reform    The 8th Annual Acquisition Research Symposium Panel #20: Investing in People

Reading Acquisition and Beyond: Decoding Includes Cognition.

ERIC Educational Resources Information Center

Perfetti, Charles A.

1984-01-01

Focuses on (1) the acquisition and use of word representations and (2) the acquisition of the alphabetic code. Urges that instruction provide conditions to promote the learning of three types of representation--word forms, letter patterns, and mapping. (RDN)

Defense Acquisition Review Journal. Volume 14, Number 2

DTIC Science & Technology

2007-09-01

2007 Vol. 14 No. 2 Learn. Perform. Succeed. Professionalism in the Acquisition Contracting Workforce Have We Gone too Far? John Krieger Contracting...acQuiSition contractinG WorKforce: HAVE WE GONE TOO FAR? John Krieger To professionalize the acquisition contracting workforce, the Department of Defense...featured author for this edition is Professor John Krieger , the Director of the Contracting Center of the Defense Acquisition University’s

Experiment research on infrared targets signature in mid and long IR spectral bands

NASA Astrophysics Data System (ADS)

Wang, Chensheng; Hong, Pu; Lei, Bo; Yue, Song; Zhang, Zhijie; Ren, Tingting

2013-09-01

Since the infrared imaging system has played a significant role in the military self-defense system and fire control system, the radiation signature of IR target becomes an important topic in IR imaging application technology. IR target signature can be applied in target identification, especially for small and dim targets, as well as the target IR thermal design. To research and analyze the targets IR signature systematically, a practical and experimental project is processed under different backgrounds and conditions. An infrared radiation acquisition system based on a MWIR cooled thermal imager and a LWIR cooled thermal imager is developed to capture the digital infrared images. Furthermore, some instruments are introduced to provide other parameters. According to the original image data and the related parameters in a certain scene, the IR signature of interested target scene can be calculated. Different background and targets are measured with this approach, and a comparison experiment analysis shall be presented in this paper as an example. This practical experiment has proved the validation of this research work, and it is useful in detection performance evaluation and further target identification research.

Acquisitions and Collection Development Automation: Future Directions.

ERIC Educational Resources Information Center

Aveney, Brian; Heinemann, Luba

1983-01-01

This paper explores features of automated acquisitions systems now implemented and discusses features that might be implemented in the next few years. Distributed acquisitions, ordering, receiving, reconciliation, management reporting, and collection development (selection of current materials, retrospective purchasing, and comparative…

12 CFR 574.3 - Acquisition of control of savings associations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... authorize such an acquisition by language to that effect and not merely by implication. [54 FR 49690, Nov... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Acquisition of control of savings associations... ACQUISITION OF CONTROL OF SAVINGS ASSOCIATIONS § 574.3 Acquisition of control of savings associations. (a...

Contrasting Predictions of the Extended Comparator Hypothesis and Acquisition-Focused Models of Learning Concerning Retrospective Revaluation

PubMed Central

McConnell, Bridget L.; Urushihara, Kouji; Miller, Ralph R.

2009-01-01

Three conditioned suppression experiments with rats investigated contrasting predictions made by the extended comparator hypothesis and acquisition-focused models of learning, specifically, modified SOP and the revised Rescorla-Wagner model, concerning retrospective revaluation. Two target cues (X and Y) were partially reinforced using a stimulus relative validity design (i.e., AX-Outcome/ BX-No outcome/ CY-Outcome/ DY-No outcome), and subsequently one of the companion cues for each target was extinguished in compound (BC-No outcome). In Experiment 1, which used spaced trials for relative validity training, greater suppression was observed to target cue Y for which the excitatory companion cue had been extinguished relative to target cue X for which the nonexcitatory companion cue had been extinguished. Experiment 2 replicated these results in a sensory preconditioning preparation. Experiment 3 massed the trials during relative validity training, and the opposite pattern of data was observed. The results are consistent with the predictions of the extended comparator hypothesis. Furthermore, this set of experiments is unique in being able to differentiate between these models without invoking higher-order comparator processes. PMID:20141324

76 FR 14566 - Federal Acquisition Regulation; Socioeconomic Program Parity

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

... 9000-AL88 Federal Acquisition Regulation; Socioeconomic Program Parity AGENCY: Department of Defense... Acquisition Regulation (FAR) to implement section 1347 of the ``Small Business Jobs Act of 2010.'' Section... acquisition will be restricted to small businesses participating in the 8(a), HUBZone, or service-disabled...

48 CFR 4.705-3 - Acquisition and supply records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition and supply... GENERAL ADMINISTRATIVE MATTERS Contractor Records Retention 4.705-3 Acquisition and supply records. (a) Store requisitions for materials, supplies, equipment, and services: Retain 2 years. (b) Work orders for...

Acquisition of Scientific Literature in Developing Countries. 2: Malaysia.