14 CFR 399.62 - Target dates in hearing cases.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Target dates in hearing cases. 399.62... Target dates in hearing cases. (a) Applicability. This section applies to initial and recommended.... (b) Issuance of target dates. In cases to which this section applies, the Board or the administrative...

14 CFR 399.62 - Target dates in hearing cases.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Target dates in hearing cases. 399.62... Target dates in hearing cases. (a) Applicability. This section applies to initial and recommended.... (b) Issuance of target dates. In cases to which this section applies, the Board or the administrative...

14 CFR 399.62 - Target dates in hearing cases.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Target dates in hearing cases. 399.62... Target dates in hearing cases. (a) Applicability. This section applies to initial and recommended.... (b) Issuance of target dates. In cases to which this section applies, the Board or the administrative...

14 CFR 399.62 - Target dates in hearing cases.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Target dates in hearing cases. 399.62... Target dates in hearing cases. (a) Applicability. This section applies to initial and recommended.... (b) Issuance of target dates. In cases to which this section applies, the Board or the administrative...

14 CFR 399.62 - Target dates in hearing cases.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Target dates in hearing cases. 399.62... Target dates in hearing cases. (a) Applicability. This section applies to initial and recommended.... (b) Issuance of target dates. In cases to which this section applies, the Board or the administrative...

Series of JASMINE missions

NASA Astrophysics Data System (ADS)

Gouda, N.

We are planning three space astrometry missions as a series of JASMINE missions; Nano-JASMINE, Small-JASMINE and (Medium-sized)JASMINE. JASMINE is an abbreviation of Japan Astrometry Satellite Mission of INfrared Exploration. The JASMINE mission will measure in an infrared band annual parallaxes, positions on the celestial sphere, and proper motions of many stars in the bulge of the Milky Way (the Galaxy) with high accuracies. A target launch date is the first half of the 2020s. Before the launch of JASMINE, we are planning Nano-JASMINE and Small-JASMINE. Nano-JASMINE uses a very small nano-satellite and it is determined to be launched in 2011. Small-JASMINE is a downsized version of the JASMINE satellite, which observes toward restricted small regions of the Galactic bulge. A target launch date is around 2016. A completely new "map" of the Galactic bulge given by Small-JASMINE and JASMINE will bring us many exciting scientific results.

ATLANTIS ROLLS OUT TO PAD 39A FOLLOWING HURRICANE FRAN THREAT

NASA Technical Reports Server (NTRS)

1996-01-01

The Space Shuttle Atlantis completes the trip to Launch Pad 39A from the Vehicle Assembly Building for the third time in the STS- 79 mission flow. The Shuttle was rolled back from the pad in July due to the threat from Hurricane Bertha, then rolled back again earlier this week because of Hurricane Fran. The targeted launch date for Atlantis on Mission STS-79 -- the fourth docking between the U.S. Shuttle and Russian Space Station Mir -- is now Sept. 16 at 4:54 a.m. EDT. The three rollout dates for Atlantis to Pad 39A are: July 1, Aug. 20 and Sept. 5.

Use of target-date funds in 401(k) plans, 2007.

PubMed

Copeland, Craig

2009-03-01

WHAT THEY ARE: Target-date funds (also called "life-cycle" funds) are a type of mutual fund that automatically rebalances its asset allocation following a predetermined pattern over time. They typically rebalance to more conservative and income-producing assets as the participant's target date of retirement approaches. WHY THEY'RE IMPORTANT AND GROWING: Of the 401(k) plan participants in the EBRI/ICI 401(k) database who were found to be in plans that offeredtarget-date funds, 37 percent had at least some fraction of their account in target-date funds in 2007. Target-date funds held about 7 percent of total assets in 401(k) plans and the use of these funds is expected to increase in the future. The Pension Protection Act of 2006 made it easier for plan sponsors to automatically enroll new workers in a 401(k) plan, and target-date funds were one of the types of approved funds specified for a "default" investment if the participant does not elect a choice. BRI/ICI 401(K) DATABASE: This study uses the unique richness of the data in the EBRI/ICI Participant-Directed Retirement Plan Data Collection Project, which has almost 22 million participants, to examine the choices and characteristics of participants whose plans offer target-date funds. EFFECT OF AGE, SALARY, JOB TENURE, AND ACCOUNT BALANCE: Younger workers are significantly more likely to invest in target-date funds than are older workers: Almost 44 percent of participants under age 30 had assets in a target-date fund, compared with 27 percent of those 60 or older. Target-date funds appeal to those with lower incomes, little time on the job, and with few assets. On average, target-date fund investors are about 2.5 years younger than those who do not invest in target-date funds, have about 3.5 years less tenure, make about $11,000 less in salary, have $25,000 less in their account, and are in smaller plans. EFFECT OF AUTOMATIC ENROLLMENT: While the EBRI/ICI database does not contain specific information on whether a 401(k) plan had automatic enrollment, this analysis was able to proxy for those who could be identified as automatically enrolled. The data show that workers who were considered to be automatically enrolled in their employer's 401(k) plan are significantly more likely to invest all their assets in a target-date fund than those who voluntarily joined, and were also less likely to have extreme all-or-nothing asset allocations to equities. EQUITY ALLOCATIONS AND FUND FAMILIES: One of the major questions surrounding target-date funds is the equity allocations that these funds use over time (the so-called "glide path") as a participant's retirement target date approaches. The glide paths of different target-date funds have significantly different shapes and starting/ending equity allocations. As of 2007, the equity allocation ranges from about 80-90 percent for 2040 funds (for workers about 30 years away from retirement), and from 26-66 percent for 2010 funds (for workers one year away from retirement)--a 40 percentage-point difference. Moreover, the fund families change their relative rank in equity allocation within the different fund years. This analysis finds that the relative rank of the equity allocation within a target-date fund does not appear to affect the percentage of participants investing all their account into that fund. Nevertheless, investors in specific fund families are more likely to invest all their assets in a single target-date fund from that family.

Present and future of metastatic colorectal cancer treatment: A review of new candidate targets

PubMed Central

Martini, Giulia; Troiani, Teresa; Cardone, Claudia; Vitiello, Pietropaolo; Sforza, Vincenzo; Ciardiello, Davide; Napolitano, Stefania; Della Corte, Carminia Maria; Morgillo, Floriana; Raucci, Antonio; Cuomo, Antonio; Selvaggi, Francesco; Ciardiello, Fortunato; Martinelli, Erika

2017-01-01

In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer (mCRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with mCRC. In this review, we describe approved targeted therapies for the management of metastatic mCRC and discuss new candidate targets on the horizon. PMID:28765689

24 CFR 3286.117 - Completion of sale date.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Completion of sale date. 3286.117...-Administered States § 3286.117 Completion of sale date. (a) Date of sale defined. For purposes of determining... chapter, the sale of a manufactured home will not be considered complete until all the goods and services...

24 CFR 3286.117 - Completion of sale date.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Completion of sale date. 3286.117...-Administered States § 3286.117 Completion of sale date. (a) Date of sale defined. For purposes of determining... chapter, the sale of a manufactured home will not be considered complete until all the goods and services...

Assessing the effects of Families for Safe Dates, a family-based teen dating abuse prevention program.

PubMed

Foshee, Vangie A; McNaughton Reyes, Heath Luz; Ennett, Susan T; Cance, Jessica D; Bauman, Karl E; Bowling, J Michael

2012-10-01

To examine the effects of a family-based teen dating abuse prevention program, Families for Safe Dates, primarily on outcomes related to testing the conceptual underpinnings of the program including (1) factors motivating and facilitating caregiver engagement in teen dating abuse prevention activities, and 2) risk factors for teen dating abuse, and secondarily on dating abuse behaviors. Families were recruited nationwide using listed telephone numbers. Caregivers and teens completed baseline and 3-month follow-up telephone interviews (n = 324). Families randomly allocated to treatment condition received the Families for Safe Dates program including six mailed activity booklets followed-up by health educator telephone calls. There were significant (<.05) treatment effects in hypothesized directions on most of the factors motivating and facilitating caregiver engagement in teen dating abuse prevention activities including caregiver perceived severity of dating abuse, response efficacy for preventing dating abuse, self-efficacy for talking about dating abuse, knowledge of dating abuse, acceptance of dating abuse, communication skills with the teen, and belief in the importance of involvement in their male (but not female) teen's dating. The latter effect was the only one moderated by sex of the teen. The targeted risk factor affected by the program was teen acceptance of dating abuse. Treatment was also significantly associated with less physical dating abuse victimization. Modifications to the program are warranted, but overall, the findings are very favorable for the first family-based teen dating abuse prevention program to be evaluated. Copyright © 2012 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Multi-targeted priming for genome-wide gene expression assays.

PubMed

Adomas, Aleksandra B; Lopez-Giraldez, Francesc; Clark, Travis A; Wang, Zheng; Townsend, Jeffrey P

2010-08-17

Complementary approaches to assaying global gene expression are needed to assess gene expression in regions that are poorly assayed by current methodologies. A key component of nearly all gene expression assays is the reverse transcription of transcribed sequences that has traditionally been performed by priming the poly-A tails on many of the transcribed genes in eukaryotes with oligo-dT, or by priming RNA indiscriminately with random hexamers. We designed an algorithm to find common sequence motifs that were present within most protein-coding genes of Saccharomyces cerevisiae and of Neurospora crassa, but that were not present within their ribosomal RNA or transfer RNA genes. We then experimentally tested whether degenerately priming these motifs with multi-targeted primers improved the accuracy and completeness of transcriptomic assays. We discovered two multi-targeted primers that would prime a preponderance of genes in the genomes of Saccharomyces cerevisiae and Neurospora crassa while avoiding priming ribosomal RNA or transfer RNA. Examining the response of Saccharomyces cerevisiae to nitrogen deficiency and profiling Neurospora crassa early sexual development, we demonstrated that using multi-targeted primers in reverse transcription led to superior performance of microarray profiling and next-generation RNA tag sequencing. Priming with multi-targeted primers in addition to oligo-dT resulted in higher sensitivity, a larger number of well-measured genes and greater power to detect differences in gene expression. Our results provide the most complete and detailed expression profiles of the yeast nitrogen starvation response and N. crassa early sexual development to date. Furthermore, our multi-targeting priming methodology for genome-wide gene expression assays provides selective targeting of multiple sequences and counter-selection against undesirable sequences, facilitating a more complete and precise assay of the transcribed sequences within the genome.

Comparison of fragments created by low- and hyper-velocity impacts

NASA Astrophysics Data System (ADS)

Hanada, T.; Liou, J.-C.

This paper summarizes two new satellite impact experiments. The objective of the experiments was to investigate the outcome of low- and hyper-velocity impacts on two identical target satellites. The first experiment was performed at a low-velocity of 1.5 km/s using a 40-g aluminum alloy sphere. The second experiment was performed at a hyper-velocity of 4.4 km/s using a 4-g aluminum alloy sphere. The target satellites were 15 cm × 15 cm × 15 cm in size and 800 g in mass. The ratios of impact energy to target mass for the two experiments were approximately the same. The target satellites were completely fragmented in both experiments, although there were some differences in the characteristics of the fragments. The projectile of the low-velocity impact experiment was partially fragmented while the projectile of the hyper-velocity impact experiment was completely fragmented beyond recognition. To date, approximately 1500 fragments from each impact experiment have been collected for detailed analysis. Each piece has been weighed, measured, and analyzed based on the analytic method used in the NASA Standard Breakup Model (2000 revision). These fragments account for about 95% of the target mass for both impact experiments. Preliminary analysis results will be presented in this paper.

26 CFR 1.338-2 - Nomenclature and definitions; mechanics of the section 338 election.

Code of Federal Regulations, 2012 CFR

2012-04-01

... corporation is, with respect to a deemed purchase of stock under section 338(a)(2), a reference to new target... date. (17) Target; old target; new target. Target is the target corporation as defined in section 338(d... date. New target refers to target for subsequent periods. (18) Target affiliate. The term target...

26 CFR 1.338-2 - Nomenclature and definitions; mechanics of the section 338 election.

Code of Federal Regulations, 2014 CFR

2014-04-01

... corporation is, with respect to a deemed purchase of stock under section 338(a)(2), a reference to new target... date. (17) Target; old target; new target. Target is the target corporation as defined in section 338(d... date. New target refers to target for subsequent periods. (18) Target affiliate. The term target...

26 CFR 1.338-2 - Nomenclature and definitions; mechanics of the section 338 election.

Code of Federal Regulations, 2013 CFR

2013-04-01

... corporation is, with respect to a deemed purchase of stock under section 338(a)(2), a reference to new target... date. (17) Target; old target; new target. Target is the target corporation as defined in section 338(d... date. New target refers to target for subsequent periods. (18) Target affiliate. The term target...

Anti-EGFR Agents: Current Status, Forecasts and Future Directions.

PubMed

Kwapiszewski, Radoslaw; Pawlak, Sebastian D; Adamkiewicz, Karolina

2016-12-01

The epidermal growth factor receptor (EGFR) is one of the most important and attractive targets for specific anticancer therapies. It is a robust regulator of pathways involved in cancer pathogenesis and progression. Thus far, clinical trials have demonstrated the benefits of monoclonal antibodies and synthetic tyrosine kinase inhibitors in targeting this receptor; however, novel strategies are still being developed. This article reviews the current state of efforts in targeting the EGFR in cancer therapy. Following a brief characterization of EGFR, we will present a complete list of anti-EGFR agents that are already approved, and available in clinical practice. Aside from the indications, we will present the sales forecasts and expiry dates of product patents for the selected agents. Finally, we discuss the novel anti-EGFR strategies that are currently in preclinical development.

26 CFR 1.338-2 - Nomenclature and definitions; mechanics of the section 338 election.

Code of Federal Regulations, 2010 CFR

2010-04-01

... purchase of stock under section 338(a)(2), a reference to new target with respect to its own deemed... target is the common parent on the acquisition date. (17) Target; old target; new target. Target is the... before the close of target's acquisition date. New target refers to target for subsequent periods. (18...

26 CFR 1.338-2 - Nomenclature and definitions; mechanics of the section 338 election.

Code of Federal Regulations, 2011 CFR

2011-04-01

... purchase of stock under section 338(a)(2), a reference to new target with respect to its own deemed... target is the common parent on the acquisition date. (17) Target; old target; new target. Target is the... before the close of target's acquisition date. New target refers to target for subsequent periods. (18...

Validation Summary Report: Verdix Corporation, VADS Sun-4 Solaris 2.1, VAda-110-4040, Version 6.2, Sun SPARCstation LX 4/30 under Solaris 2.1 (Host & Target), 921004W1.11285

DTIC Science & Technology

1992-03-19

Sun SPARCstation LX 4/30 under Solaris 2.1 Customer Agreement Number: 92-06-23- VRX See section 3.1 for any additional information about the testing...mber: AVF-VSR-556-1092 Date VSR Complete: 18 November 1992 92-06-23- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 921004W1.11285

Validation Summary Report: Verdix Corporation, VADSself HP 9000 Series 700 VAda-110-7575, Version 6.2, HP 9000/720 Under HP/UX 8.0.7 (Host & Target), 930226W1.11311

DTIC Science & Technology

1993-02-26

2-89) Prescribed by ANSI Sid 239-128 AVF Control Number: AVF-VSR-561-0293 Date VSR Completed: 15 February 1993 93-01-25- VRX Ada COMPILER VALIDATION...Agreement Number: 93-01-2S- VRX See section 3.1 for any additional information about the testing environment. As a result of this validation effort

Joint Loads and Cartilage Stress in Intact Joints of Military Transtibial Amputees: Enhancing Quality of Life

DTIC Science & Technology

2017-04-01

crosstalk); analysis of tested subjects underway. 4) Developed analytical methods to obtain knee joint loads using EMG-driven inverse dynamics; analysis of...13/2018. Completion %: 40. Task 1.3: EMG-driven inverse dynamic (ID) analyses with OpenSim for amputee and control group subjects. Target date: 1...predicted by EMG-driven inverse dynamics. Two-three conference papers are being prepared for submission in February 2017. Other achievements. None

Preliminary Quantification of Image Color Gradient on Genesis Concentrator Silicon Carbine Target 60001

NASA Technical Reports Server (NTRS)

Allton, J. H.; Calaway, M. J.; Rodriquez, M. C.

2008-01-01

The Genesis spacecraft concentrator was a device to focus solar wind ions onto a 6-cm diameter target area, thus concentrating the solar wind by 20X [1]. The target area was comprised of 4 quadrants held in place by a gold-coated stainless steel "cross" (Fig. 1). To date, two SiC and one chemical vapor deposited (CVD) quadrants have been imaged at 5X using a Leica DM-6000M in autoscan mode. Complete imaging of SiC sample 60001 required 1036 images. The mosaic of images is shown in Fig. 2 and position of analyzed areas in Fig. 3. This mosaic imaging is part of the curatorial documentation of surface condition and mapping of contamination. Higher magnification (50X) images of selected areas of the target and individual contaminant particles are compiled into reports which may be requested from the Genesis Curator [2].

36 CFR 223.47 - Date of completion of permanent road construction.

Code of Federal Regulations, 2010 CFR

2010-07-01

... permanent road construction. 223.47 Section 223.47 Parks, Forests, and Public Property FOREST SERVICE... Conditions and Provisions § 223.47 Date of completion of permanent road construction. (a) The date of completion of permanent road construction obligations as set forth in the Notice of Sale shall be...

Army Needs to Improve the Reliability of the Spare Parts Forecasts It Submits to the Defense Logistics Agency

DTIC Science & Technology

2014-09-29

In response to this finding, AMC is initiating a Depot Material Requirements Planning ( MRP ) Integrated Process Team (IPT) from which one objective...methodologies for DOF reviews and corrective actions by AMC and its component organizations. The target completion date for the Depot MRP IPT is June...implemented a matrix for MRP SOW where the aviation programs were updated in Production LMP 1QFY14. Army Materiel Command (cont’d) Management

Sulforaphane Treatment of Children with Autism Spectrum Disorder

DTIC Science & Technology

2017-07-01

the course of the study . To date, the Pilot trial of 10 children has been completed, and 36 out of the target 50 children for the Main trial have... study will enroll 50 children with moderate to severe autism, between 3 and 12 years old, in a randomized, double-blind, placebo-controlled phase-2... children were unable to cooperate, and because in some cases study participants took the study drug in the morning and then went to school for the

Target development for 67Cu, 82Sr radionuclide production at the RIC-80 facility

NASA Astrophysics Data System (ADS)

Panteleev, V. N.; Barzakh, A. E.; Batist, L. Kh.; Fedorov, D. V.; Ivanov, V. S.; Krotov, S. A.; Molkanov, P. L.; Moroz, F. V.; Orlov, S. Yu.; Volkov, Yu. M.

2018-01-01

A high-current cyclotron C-80 capable of producing 40-80 MeV proton beams with a current of up to 200 μA has been constructed and commissioned at PNPI (Petersburg Nuclear Physics Institute). One of the main goals of cyclotron C-80 is the production of a wide spectrum of medical radionuclides for diagnostics and therapy. To date, the project development of a radioisotope facility RIC-80 (radioisotopes at cyclotron C-80) has been completed. The feature of the project is the use of a mass-separator combined with the ion-target device for obtaining ion beams of radioisotopes with a high purity of separation that is especially important for medical applications. The first results of a new high-temperature method for extracting 82Sr and 67Cu radioisotopes from irradiated targets have been presented.

The immune epitope database (IEDB) 3.0

PubMed Central

Vita, Randi; Overton, James A.; Greenbaum, Jason A.; Ponomarenko, Julia; Clark, Jason D.; Cantrell, Jason R.; Wheeler, Daniel K.; Gabbard, Joseph L.; Hix, Deborah; Sette, Alessandro; Peters, Bjoern

2015-01-01

The IEDB, www.iedb.org, contains information on immune epitopes—the molecular targets of adaptive immune responses—curated from the published literature and submitted by National Institutes of Health funded epitope discovery efforts. From 2004 to 2012 the IEDB curation of journal articles published since 1960 has caught up to the present day, with >95% of relevant published literature manually curated amounting to more than 15 000 journal articles and more than 704 000 experiments to date. The revised curation target since 2012 has been to make recent research findings quickly available in the IEDB and thereby ensure that it continues to be an up-to-date resource. Having gathered a comprehensive dataset in the IEDB, a complete redesign of the query and reporting interface has been performed in the IEDB 3.0 release to improve how end users can access this information in an intuitive and biologically accurate manner. We here present this most recent release of the IEDB and describe the user testing procedures as well as the use of external ontologies that have enabled it. PMID:25300482

75 FR 18236 - In the Matter of Certain Coaxial Cable Connectors and Components Thereof and Products Containing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... General Exclusion Order, a Limited Exclusion Order, and a Remand Order; Extension of Target Date AGENCY: U... Commission has determined to extend the target date by 60 days until May 26, 2010. FOR FURTHER INFORMATION... issuance. Finally, the Commission has determined to extend the target date from March 26, 2010, to May 26...

78 FR 29770 - Notice of Fund Availability (NOFA) for the Neighborhood Stabilization Program 2 (NSP2) Under the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-21

.... This data is now dated and in many cases it no longer reflects the foreclosure market in NSP2 target... needs index score in selecting geographic target areas. DATES: Effective Date: May 21, 2013. FOR FURTHER... NSP2 NOFA requires grantees to carry out NSP2 activities in a HUD-approved target area. HUD developed a...

49 CFR 381.510 - May the FMCSA end a pilot program before its scheduled completion date?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 5 2013-10-01 2013-10-01 false May the FMCSA end a pilot program before its scheduled completion date? 381.510 Section 381.510 Transportation Other Regulations Relating to... Pilot Programs § 381.510 May the FMCSA end a pilot program before its scheduled completion date? The...

49 CFR 381.510 - May the FMCSA end a pilot program before its scheduled completion date?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 5 2014-10-01 2014-10-01 false May the FMCSA end a pilot program before its scheduled completion date? 381.510 Section 381.510 Transportation Other Regulations Relating to... Pilot Programs § 381.510 May the FMCSA end a pilot program before its scheduled completion date? The...

Characterization of Near-Earth Asteroids Using KMTNET-SAAO

NASA Astrophysics Data System (ADS)

Erasmus, N.; Mommert, M.; Trilling, D. E.; Sickafoose, A. A.; van Gend, C.; Hora, J. L.

2017-10-01

We present here VRI spectrophotometry of 39 near-Earth asteroids (NEAs) observed with the Sutherland, South Africa, node of the Korea Microlensing Telescope Network (KMTNet). Of the 39 NEAs, 19 were targeted, but because of KMTNet’s large 2° × 2° field of view, 20 serendipitous NEAs were also captured in the observing fields. Targeted observations were performed within 44 days (median: 16 days, min: 4 days) of each NEA’s discovery date. Our broadband spectrophotometry is reliable enough to distinguish among four asteroid taxonomies and we were able to confidently categorize 31 of the 39 observed targets as either an S-, C-, X-, or D-type asteroid by means of a Machine Learning algorithm approach. Our data suggest that the ratio between “stony” S-type NEAs and “not-stony” (C+X+D)-type NEAs, with H magnitudes between 15 and 25, is roughly 1:1. Additionally, we report ∼1 hr light curve data for each NEA, and of the 39 targets, we were able to resolve the complete rotation period and amplitude for six targets and report lower limits for the remaining targets.

Targeting Ovarian Cancer with Porphysome Nanotechnology

DTIC Science & Technology

2016-10-01

ORGANIZATION: University Health Network Toronto, ON, Canada M5G 2C4 REPORT DATE : October 2016 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army...THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) October 2016 2. REPORT TYPE Annual 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Targeting...non-targeted Porphysomes for the detection of orthotopic ovarian lesions. Methods : Two ovarian tumour xenograft models are established with human SK

K2: Extending Kepler's Power to the Ecliptic-Ecliptic Plane Input Catalog

NASA Technical Reports Server (NTRS)

Huber, Daniel; Bryson, Stephen T.

2017-01-01

This document describes the Ecliptic Plane Input Catalog (EPIC) for the K2 mission (Howell et al. 2014). The primary purpose of this catalog is to provide positions and Kepler magnitudes for target management and aperture photometry. The Ecliptic Plane Input Catalog is hosted at MAST (http://archive.stsci.edu/k2/epic/search.php) and should be used for selecting targets when ever possible. The EPIC is updated for future K2 campaigns as their fields of view are finalized and the associated target management is completed. Table 0 summarizes the EPIC updates to date and the ID range for each. The main algorithms used to construct the EPIC are described in Sections 2 through 4. The details for individual campaigns are described in the subsequent sections, with the references listed in the last section. Further details can be found in Huber et al. (2016).

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

PubMed Central

Huang, Pengxiang; Chandra, Vikas; Rastinejad, Fraydoon

2013-01-01

As ligand-regulated transcription factors, the nuclear hormone receptors are nearly ideal drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well-characterized ligand-induced conformational changes that recruit transcriptional coregulators to promoter elements. Yet, due to the multitude of genes under the control of a single receptor, the major challenge has been the identification of ligands with gene-selective actions, impacting disease outcomes through a narrow subset of target genes and not across their entire gene-regulatory repertoire. Here, we summarize the concepts and work to date underlying the development of steroidal and nonsteroidal receptor ligands, including the use of crystal structures, high-throughput screens, and rational design approaches for finding useful therapeutic molecules. Difficulties in finding selective receptor modulators require a more complete understanding of receptor interdomain communications, posttranslational modifications, and receptor-protein interactions that could be exploited for target gene selectivity. PMID:20148675

Attentional capture in visual search: Capture and post-capture dynamics revealed by EEG.

PubMed

Liesefeld, Heinrich René; Liesefeld, Anna Marie; Töllner, Thomas; Müller, Hermann J

2017-08-01

Sometimes, salient-but-irrelevant objects (distractors) presented concurrently with a search target cannot be ignored and attention is involuntarily allocated towards the distractor first. Several studies have provided electrophysiological evidence for involuntary misallocations of attention towards a distractor, but much less is known about the mechanisms that are needed to overcome a misallocation and re-allocate attention towards the concurrently presented target. In our study, electrophysiological markers of attentional mechanisms indicate that (i) the distractor captures attention before the target is attended, (ii) a misallocation of attention is terminated actively (instead of attention fading passively), and (iii) the misallocation of attention towards a distractor delays the attention allocation towards the target (rather than just delaying some post-attentive process involved in response selection). This provides the most complete demonstration, to date, of the chain of attentional mechanisms that are evoked when attention is misguided and recovers from capture within a search display. Copyright © 2017 Elsevier Inc. All rights reserved.

Enhanced flyby science with onboard computer vision: Tracking and surface feature detection at small bodies

NASA Astrophysics Data System (ADS)

Fuchs, Thomas J.; Thompson, David R.; Bue, Brian D.; Castillo-Rogez, Julie; Chien, Steve A.; Gharibian, Dero; Wagstaff, Kiri L.

2015-10-01

Spacecraft autonomy is crucial to increase the science return of optical remote sensing observations at distant primitive bodies. To date, most small bodies exploration has involved short timescale flybys that execute prescripted data collection sequences. Light time delay means that the spacecraft must operate completely autonomously without direct control from the ground, but in most cases the physical properties and morphologies of prospective targets are unknown before the flyby. Surface features of interest are highly localized, and successful observations must account for geometry and illumination constraints. Under these circumstances onboard computer vision can improve science yield by responding immediately to collected imagery. It can reacquire bad data or identify features of opportunity for additional targeted measurements. We present a comprehensive framework for onboard computer vision for flyby missions at small bodies. We introduce novel algorithms for target tracking, target segmentation, surface feature detection, and anomaly detection. The performance and generalization power are evaluated in detail using expert annotations on data sets from previous encounters with primitive bodies.

Plan demographics, participants' saving behavior, and target-date fund investments.

PubMed

Park, Youngkyun

2009-05-01

This analysis explores (1) whether plan demographic characteristics would affect individual participant contribution rates and target-date fund investments and (2) equity glide paths for participants in relation to plan demographics by considering target replacement income and its success rate. PLAN DEMOGRAPHIC CHARACTERISTICS IN PARTICIPANT CONTRIBUTION RATES: This study finds empirical evidence that 401(k) plan participants' contribution rates differ by plan demographics based on participants' income and/or tenure. In particular, participants in 401(k) plans dominated by those with low income and short tenure tend to contribute less than those in plans dominated by participants with high income and long tenure. Future research will explore how participant contribution behavior may also be influenced by incentives provided by employers through matching formulae. PLAN DEMOGRAPHIC CHARACTERISTICS IN TARGET-DATE FUND INVESTMENTS: The study also finds empirical evidence that participants' investments in target-date funds with different equity allocations differ by plan demographics based on participants' income and/or tenure. In particular, target-date fund users with 90 percent or more of their account balances in target-date funds who are in 401(k) plans dominated by low-income and short-tenure participants tend to hold target-date funds with lower equity allocations, compared with their counterparts in plans dominated by high-income and long-tenure participants. Future research will focus on the extent to which these characteristics might influence the selection of target-date funds by plan sponsors. EQUITY GLIDE PATHS: Several stylized equity glide paths as well as alternative asset allocations are compared for participants at various starting ages to demonstrate the interaction between plan demographics and equity glide paths/asset allocations in terms of success rates in meeting various replacement income targets. The equity glide path/asset allocation providing the highest success rate at a particular replacement rate target will vary with the assumed starting date of the participant (see Figure 17). Given the highly stylized nature of the simulations in this Issue Brief it is important to note that the results are not intended to provide a single equity glide path solution in relation to plan demographics. Instead, they serve as a framework to be considered when plan sponsors make a selection concerning which target-date funds to include in their plan. IMPORTANCE OF PARTICIPANT CONTRIBUTION RATES: This analysis finds that although target-date funds with different equity glide paths affect the retirement income replacement success rate, participant contribution rates corresponding to different plan demographic characteristics have a stronger impact. AUTO FEATURES OF THE PPA: This Issue Brief provides a stylized study using observed contribution rates as of the 2007 plan year. However, with the passage of the Pension Protection Act of 2006 and its likely impact on plan design in the future (increased utilization of automatic enrollment and automatic contribution escalations), it is likely that contribution rates among the participants may become more homogenous. In such a scenario, it may be more likely that a single equity glide path would meet a wide range of demographic profiles.

Witnessing Interparental Violence and Acceptance of Dating Violence as Predictors for Teen Dating Violence Victimization.

PubMed

Karlsson, Marie E; Temple, Jeff R; Weston, Rebecca; Le, Vi Donna

2016-04-01

We examined the association between witnessing interparental violence, attitudes about dating violence, and physical and psychological teen dating violence (TDV) victimization. Participants were 918 teens with dating experience. Witnessing interparental violence and acceptance of dating violence were significant predictors of TDV victimization. Acceptance of dating violence was also a partial mediator between witnessing interparental violence and TDV victimization. Witnessing mother-to-father violence and acceptance of female-perpetrated violence were the most consistent predictors. TDV programs aiming to prevent victimization could benefit from targeting youth exposed to father-to-mother and mother-to-father violence, targeting attitudes about violence, and tailoring interventions to gender-specific risk factors. © The Author(s) 2015.

A prototype for automation of land-cover products from Landsat Surface Reflectance Data Records

NASA Astrophysics Data System (ADS)

Rover, J.; Goldhaber, M. B.; Steinwand, D.; Nelson, K.; Coan, M.; Wylie, B. K.; Dahal, D.; Wika, S.; Quenzer, R.

2014-12-01

Landsat data records of surface reflectance provide a three-decade history of land surface processes. Due to the vast number of these archived records, development of innovative approaches for automated data mining and information retrieval were necessary. Recently, we created a prototype utilizing open source software libraries for automatically generating annual Anderson Level 1 land cover maps and information products from data acquired by the Landsat Mission for the years 1984 to 2013. The automated prototype was applied to two target areas in northwestern and east-central North Dakota, USA. The approach required the National Land Cover Database (NLCD) and two user-input target acquisition year-days. The Landsat archive was mined for scenes acquired within a 100-day window surrounding these target dates, and then cloud-free pixels where chosen closest to the specified target acquisition dates. The selected pixels were then composited before completing an unsupervised classification using the NLCD. Pixels unchanged in pairs of the NLCD were used for training decision tree models in an iterative process refined with model confidence measures. The decision tree models were applied to the Landsat composites to generate a yearly land cover map and related information products. Results for the target areas captured changes associated with the recent expansion of oil shale production and agriculture driven by economics and policy, such as the increase in biofuel production and reduction in Conservation Reserve Program. Changes in agriculture, grasslands, and surface water reflect the local hydrological conditions that occurred during the 29-year span. Future enhancements considered for this prototype include a web-based client, ancillary spatial datasets, trends and clustering algorithms, and the forecasting of future land cover.

Characterization of Near-Earth Asteroids Using KMTNET-SAAO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erasmus, N.; Trilling, D. E.; Sickafoose, A. A.

We present here VRI spectrophotometry of 39 near-Earth asteroids (NEAs) observed with the Sutherland, South Africa, node of the Korea Microlensing Telescope Network (KMTNet). Of the 39 NEAs, 19 were targeted, but because of KMTNet’s large 2° × 2° field of view, 20 serendipitous NEAs were also captured in the observing fields. Targeted observations were performed within 44 days (median: 16 days, min: 4 days) of each NEA’s discovery date. Our broadband spectrophotometry is reliable enough to distinguish among four asteroid taxonomies and we were able to confidently categorize 31 of the 39 observed targets as either an S-, C-, X-, ormore » D-type asteroid by means of a Machine Learning algorithm approach. Our data suggest that the ratio between “stony” S-type NEAs and “not-stony” (C+X+D)-type NEAs, with H magnitudes between 15 and 25, is roughly 1:1. Additionally, we report ∼1 hr light curve data for each NEA, and of the 39 targets, we were able to resolve the complete rotation period and amplitude for six targets and report lower limits for the remaining targets.« less

24 CFR 3282.412 - Completion of remedial actions and report.

Code of Federal Regulations, 2010 CFR

2010-04-01

... files for five years from the date the notification campaign is completed a copy of the notice sent and a complete list of the people and their addresses. The files referred to in this section shall be... maintain in its files, for five years from the date the correction campaign is completed, one of the...

49 CFR 37.59 - Differences in accessibility completion dates.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Differences in accessibility completion dates. 37.59 Section 37.59 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Transportation Facilities § 37.59 Differences in accessibility completion...

ATLANTIS ROLLS OUT TO PAD 39A FOLLOWING HURRICANE FRAN THREAT

NASA Technical Reports Server (NTRS)

1996-01-01

A view from the flame trench looking up shows the Space Shuttle Atlantis, mounted on the Mobile Launcher Platform and Crawler- Transporter, as it arrives atop the hardstand at Launch Pad 39A. After the Shuttle and launch stand are in position, the crawler will be pulled back. This is the third time Atlantis has completed the journey to Launch Pad 39A in the STS-79 mission flow. The Shuttle was rolled back from the pad in July due to the threat from Hurricane Bertha, then rolled back again earlier this week because of Hurricane Fran. The targeted launch date for Atlantis on Mission STS-79 -- the fourth docking between the U.S. Shuttle and Russian Space Station Mir -- is now Sept. 16 at 4:54 a.m. EDT. The three rollout dates for Atlantis to Pad 39A are: July 1, Aug. 20 and Sept. 5.

Justice Delayed

PubMed Central

2017-01-01

Abstract Tens of thousands of women were coercively sterilized in Czechoslovakia and its successor states. Romani women were particularly targeted for these measures. These practices stopped only in 2004, as a result of international pressure. Although some measures have been taken to ensure that these practices are not repeated, to date neither the Czech Republic nor Slovakia have completed the work of providing effective remedy to victims, as is their right. This article focusses on efforts in the Czech Republic. It concludes that, inter alia, an administrative mechanism is needed to provide financial compensation to victims, since the road to remedy via courts is effectively blocked. PMID:29302159

Theranostics Targeting Metastatic Breast Cancer

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-1-0389 TITLE: Theranostics Targeting Metastatic Breast Cancer PRINCIPAL INVESTIGATOR: Kevin Burgess CONTRACTING...ADDRESS. 1. REPORT DATE October 2017 2. REPORT TYPE Annual 3. DATES COVERED 4. TITLE AND SUBTITLE Theranostics Targeting Metastatic Breast Cancer 5a...safe and effective interventions; (ii) elimination of mortality associated with metastatic breast cancer ; and, (iii) distinguishing aggressive breast

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs.

PubMed

Marks, Paul A

2010-09-01

Histone deacetylase (HDAC) inhibitors are being developed as a new, targeted class of anticancer drugs. This review focuses on the mechanisms of action of the HDAC inhibitors, which selectively induce cancer cell death. There are 11 zinc-dependent HDACs in humans and the biological roles of these lysine deacetylases are not completely understood. It is clear that these different HDACs are not redundant in their activity. This review focuses on the mechanisms by which HDAC inhibitors can induce transformed cell growth arrest and cell death, inhibit cell mobility and have antiangiogenesis activity. There are more than a dozen HDAC inhibitors, including hydroxamates, cyclic peptides, benzamides and fatty acids, in various stages of clinical trials and many more compounds in preclinical development. The chemically different HDAC inhibitors may target different HDACs. There are extensive preclinical studies with transformed cells in culture and tumor-bearing animal models, as well as limited clinical studies reported to date, which indicate that HDAC inhibitors will be most useful when used in combination with cytotoxic or other targeted anticancer agents.

The advanced linked extended reconnaissance and targeting technology demonstration project

NASA Astrophysics Data System (ADS)

Cruickshank, James; de Villers, Yves; Maheux, Jean; Edwards, Mark; Gains, David; Rea, Terry; Banbury, Simon; Gauthier, Michelle

2007-06-01

The Advanced Linked Extended Reconnaissance & Targeting (ALERT) Technology Demonstration (TD) project is addressing key operational needs of the future Canadian Army's Surveillance and Reconnaissance forces by fusing multi-sensor and tactical data, developing automated processes, and integrating beyond line-of-sight sensing. We discuss concepts for displaying and fusing multi-sensor and tactical data within an Enhanced Operator Control Station (EOCS). The sensor data can originate from the Coyote's own visible-band and IR cameras, laser rangefinder, and ground-surveillance radar, as well as beyond line-of-sight systems such as a mini-UAV and unattended ground sensors. The authors address technical issues associated with the use of fully digital IR and day video cameras and discuss video-rate image processing developed to assist the operator to recognize poorly visible targets. Automatic target detection and recognition algorithms processing both IR and visible-band images have been investigated to draw the operator's attention to possible targets. The machine generated information display requirements are presented with the human factors engineering aspects of the user interface in this complex environment, with a view to establishing user trust in the automation. The paper concludes with a summary of achievements to date and steps to project completion.

Ada Compiler Validation Summary Report: Certificate Number 891201S1. 10213 U.S. Navy Ada/M Version 2.0 (/NO Optimize Option) VAX 8550 and VAX 11/785 Hosts and AN/UYK-44 Target

DTIC Science & Technology

1989-12-01

T~IC F LE COK _"_ "NTATION PAGE I r070O18- AD-A223 693 M w-__wow_=ORT DATE ILREPORT TYP ND DATES CM RID I Dec 89 to I Dec 90 Final 4.1LE frMlTWLE...target), 891201.10213 LAVUTORS) National Institute of Standards and Technology Gaithersburg, MD USA 7 . PEWOOMWOPAA AT HW M S) L PEVodM ORGANIZATION 7 ...DATE VSR CCLPIETED BEFORE CN-SITE: 08-11-89 DATE VSR CPEIED AFE ON-SITE: 12-04-89 DATE VSR MODIFIED PER AVO CCMKENTS: 12-29-89 DATE VSR MODIFIED PER AVO

A feasibility study to assess the effectiveness of safe dates for teen mothers.

PubMed

Herrman, Judith W; Waterhouse, Julie K

2014-01-01

To determine the effectiveness of the adapted Safe Dates curriculum as an intervention for pregnant and/or parenting teens to prevent teen dating violence (TDV). This pre-/posttest, single-sample study provided a means to assess the effectiveness of an adapted Safe Dates curriculum for teen mothers. The adapted Safe Dates curriculum was implemented in three schools designed for the unique needs of teens who are pregnant and/or parenting. The final sample of 41 teen participants, with a mean age of 16.27, completed 80% of the curriculum and two of the three assessments. Most of the teens were pregnant during participation in the curriculum, and six had infants between age 1 and 3 months. The teen mothers completed the pretest, participated in the 10-session adapted Safe Dates curriculum, and completed the posttest at the end of the program and 1 month after program completion. The pre/posttest was adapted from the Safe Dates curriculum-specific evaluation instrument. Senior, undergraduate nursing students were trained in and implemented the curriculum. Participation in the adapted Safe Dates program yielded significant differences in the areas of responses to anger, gender stereotyping, awareness of resources for perpetrators and victims, and psychological violence perpetration. This adapted program may be effective in changing selected outcomes. The implementation of a larger scale, experimental/control group study may demonstrate the program's efficacy at reducing the incidence of TDV among teen mothers. © 2014 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses.

Up-Dating: Ratings of Perceived Dating Success Are Better Online than Offline.

PubMed

Fullwood, Chris; Attrill-Smith, Alison

2018-01-01

The primary aims of this study were to test whether perceived dating success would differ between offline and online zero-acquaintance dating contexts and to investigate the role that self-esteem might play in these evaluations. Participants were presented with the same photos of targets in either an offline or online dating scenario and rated their chances of dating success along with their perceptions of how attractive they thought the target would consider them. Higher self-esteem individuals believed they would be rated as more attractive. There was an overall perception that, irrespective of self-esteem level, meeting online would lead to better chances of dating success. These findings are considered in relation to an increased ability to more precisely manage impressions and develop an image of the self which would be evaluated more positively online.

Cancer and Stroma-Targeted Immunotherapy with a Genetically Modified DC Vaccine

DTIC Science & Technology

2013-05-01

of Medicine One Baylor Plaza Houston, TX 77030 REPORT DATE: May 2013 TYPE OF REPORT: Final PREPARED FOR: U.S. Army Medical...information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE May ...2013 2. REPORT TYPE Final report 3. DATES COVERED 01 May 2010 - 30 April 2013 4. TITLE AND SUBTITLE Cancer and Stroma-Targeted Immunotherapy

75 FR 5798 - National Institute on Drug Abuse; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Drug..., Targeted Library Synthesis and Screening at Novel Targets for Potential Drug Addiction (R21/R33). Date... Panel, Diversity-promoting Institutions' Drug Abuse Research Development Program. Date: February 25...

Kepler Planet Detection Metrics: Per-Target Flux-Level Transit Injection Tests of TPS for Data Release 25

NASA Technical Reports Server (NTRS)

Burke, Christopher J.; Catanzarite, Joseph

2017-01-01

Quantifying the ability of a transiting planet survey to recover transit signals has commonly been accomplished through Monte-Carlo injection of transit signals into the observed data and subsequent running of the signal search algorithm (Gilliland et al., 2000; Weldrake et al., 2005; Burke et al., 2006). In order to characterize the performance of the Kepler pipeline (Twicken et al., 2016; Jenkins et al., 2017) on a sample of over 200,000 stars, two complementary injection and recovery tests are utilized:1. Injection of a single transit signal per target into the image or pixel-level data, hereafter referred to as pixel-level transit injection (PLTI), with subsequent processing through the Photometric Analysis (PA), Presearch Data Conditioning (PDC), Transiting Planet Search (TPS), and Data Validation (DV) modules of the Kepler pipeline. The PLTI quantification of the Kepler pipeline's completeness has been described previously by Christiansen et al. (2015, 2016); the completeness of the final SOC 9.3 Kepler pipeline acting on the Data Release 25 (DR25) light curves is described by Christiansen (2017).2. Injection of multiple transit signals per target into the normalized flux time series data with a subsequent transit search using a stream-lined version of the Transiting Planet Search (TPS) module. This test, hereafter referred to as flux-level transit injection (FLTI), is the subject of this document. By running a heavily modified version of TPS, FLTI is able to perform many injections on selected targets and determine in some detail which injected signals are recoverable. Significant numerical efficiency gains are enabled by precomputing the data conditioning steps at the onset of TPS and limiting the search parameter space (i.e., orbital period, transit duration, and ephemeris zero-point) to a small region around each injected transit signal.The PLTI test has the advantage that it follows transit signals through all processing steps of the Kepler pipeline, and the recovered signals can be further classified as planet candidates or false positives in the exact same manner as detections from the nominal (i.e., observed) pipeline run (Twicken et al., 2016, Thompson et al., in preparation). To date, the PLTI test has been the standard means of measuring pipeline completeness averaged over large samples of targets (Christiansen et al., 2015, 2016; Christiansen, 2017). However, since the PLTI test uses only one injection per target, it does not elucidate individual-target variations in pipeline completeness due to differences in stellar properties or astrophysical variability. Thus, we developed the FLTI test to provide a numerically efficient way to fully map individual targets and explore the performance of the pipeline in greater detail. The FLTI tests thereby allow a thorough validation of the pipeline completeness models (such as window function (Burke and Catanzarite, 2017a), detection efficiency (Burke Catanzarite, 2017b), etc.) across the spectrum of Kepler targets (i.e., various astrophysical phenomena and differences in instrumental noise). Tests during development of the FLTI capability revealed that there are significant target-to-target variations in the detection efficiency.

The Impacts of Using Smartphone Dating Applications on Sexual Risk Behaviours in College Students in Hong Kong.

PubMed

Choi, Edmond Pui-Hang; Wong, Janet Yuen-Ha; Lo, Herman Hay-Ming; Wong, Wendy; Chio, Jasmine Hin-Man; Fong, Daniel Yee-Tak

2016-01-01

Dating applications (apps) on smartphones have become increasingly popular. The aim of this study was to explore the association between the use of dating apps and risky sexual behaviours. Data were collected in four university campuses in Hong Kong. Subjects completed a structured questionnaire asking about the use of dating apps, sexual behaviours, and sociodemographics. Multiple linear and logistics regressions were used to explore factors associated with sexual risk behaviours. Six hundred sixty-six subjects were included in the data analysis. Factors associated with having unprotected sexual intercourse with more lifetime sexual partners included use of dating apps (β = 0.93, p<0.01), having one's first sexual intercourse before 16 years of age (β = 1.74, p<0.01), being older (β = 0.4, p<0.01), currently being in a relationship (= 0.69, p<0.05), having a monthly income at least HKD$5,000 (β = 1.34, p<0.01), being a current smoker (β = 1.52, p<0.01), and being a current drinker (β = 0.7, p<0.01). The results of a multiple logistic regression analysis found that users of dating apps (adjust odds ratio: 0.52, p<0.05) and current drinkers (adjust odds ratio: 0.40, p<0.01) were less likely to have consistent condom use. Users of dating apps (adjust odds ratio: 1.93, p<0.05), bisexual/homosexual subjects (adjust odds ratio: 2.57, p<0.01) and female subjects (adjust odds ratio: 2.00, p<0.05) were more likely not to have used condoms the last time they had sexual intercourse. The present study found a robust association between using dating apps and sexual risk behaviours, suggesting that app users had greater sexual risks. Interventions that can target app users so that they can stay safe when seeking sexual partners through dating apps should be developed.

The Impacts of Using Smartphone Dating Applications on Sexual Risk Behaviours in College Students in Hong Kong

PubMed Central

2016-01-01

Dating applications (apps) on smartphones have become increasingly popular. The aim of this study was to explore the association between the use of dating apps and risky sexual behaviours. Data were collected in four university campuses in Hong Kong. Subjects completed a structured questionnaire asking about the use of dating apps, sexual behaviours, and sociodemographics. Multiple linear and logistics regressions were used to explore factors associated with sexual risk behaviours. Six hundred sixty-six subjects were included in the data analysis. Factors associated with having unprotected sexual intercourse with more lifetime sexual partners included use of dating apps (β = 0.93, p<0.01), having one’s first sexual intercourse before 16 years of age (β = 1.74, p<0.01), being older (β = 0.4, p<0.01), currently being in a relationship (= 0.69, p<0.05), having a monthly income at least HKD$5,000 (β = 1.34, p<0.01), being a current smoker (β = 1.52, p<0.01), and being a current drinker (β = 0.7, p<0.01). The results of a multiple logistic regression analysis found that users of dating apps (adjust odds ratio: 0.52, p<0.05) and current drinkers (adjust odds ratio: 0.40, p<0.01) were less likely to have consistent condom use. Users of dating apps (adjust odds ratio: 1.93, p<0.05), bisexual/homosexual subjects (adjust odds ratio: 2.57, p<0.01) and female subjects (adjust odds ratio: 2.00, p<0.05) were more likely not to have used condoms the last time they had sexual intercourse. The present study found a robust association between using dating apps and sexual risk behaviours, suggesting that app users had greater sexual risks. Interventions that can target app users so that they can stay safe when seeking sexual partners through dating apps should be developed. PMID:27828997

Environmental Assessment: 2005 Base Realignment and Closure Seymour Johnson Air Force Base Goldsboro, North Carolina

DTIC Science & Technology

2007-07-01

clearance criteria is being prepared. Expected completion date: __ _ A temporary waiver for construction activity in the airfield vacinity was approved on...space clearance criteria is being prepared. Expected completion date: __ _ A temporary waiver for construction activity in the airfield vacinity was...construction activity in the airfield vacinity was approved on ____ (date). A permanent waiver of airfield/airspace clearance criteria was obtained on

Targeting ESR1-Mutant Breast Cancer

DTIC Science & Technology

2015-09-01

Award Number: W81XWH-14-1-0360 TITLE: Targeting ESR1 -Mutant Breast Cancer PRINCIPAL INVESTIGATOR: Geoffrey L. Greene, Ph.D. CONTRACTING...ADDRESS. 1. REPORT DATE September 2015 2. REPORT TYPE Annual 3. DATES COVERED 1 Sep 2014 - 31 Aug 2015 4. TITLE AND SUBTITLE Targeting ESR1 -Mutant...Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The hypothesis of this proposal is that LBD mutations in ESR1 promote resistance to current FDA

Adaptive Filter Techniques for Optical Beam Jitter Control and Target Tracking

DTIC Science & Technology

2008-12-01

OPTICAL BEAM JITTER CONTROL AND TARGET TRACKING Michael J. Beerer Civilian, United States Air Force B.S., University of California Irvine, 2006...TECHNIQUES FOR OPTICAL BEAM JITTER CONTROL AND TARGET TRACKING by Michael J. Beerer December 2008 Thesis Advisor: Brij N. Agrawal Co...DATE December 2008 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Adaptive Filter Techniques for Optical Beam Jitter

One Bacterial Cell, One Complete Genome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woyke, Tanja; Tighe, Damon; Mavrommatis, Konstantinos

2010-04-26

While the bulk of the finished microbial genomes sequenced to date are derived from cultured bacterial and archaeal representatives, the vast majority of microorganisms elude current culturing attempts, severely limiting the ability to recover complete or even partial genomes from these environmental species. Single cell genomics is a novel culture-independent approach, which enables access to the genetic material of an individual cell. No single cell genome has to our knowledge been closed and finished to date. Here we report the completed genome from an uncultured single cell of Candidatus Sulcia muelleri DMIN. Digital PCR on single symbiont cells isolated frommore » the bacteriome of the green sharpshooter Draeculacephala minerva bacteriome allowed us to assess that this bacteria is polyploid with genome copies ranging from approximately 200?900 per cell, making it a most suitable target for single cell finishing efforts. For single cell shotgun sequencing, an individual Sulcia cell was isolated and whole genome amplified by multiple displacement amplification (MDA). Sanger-based finishing methods allowed us to close the genome. To verify the correctness of our single cell genome and exclude MDA-derived artifacts, we independently shotgun sequenced and assembled the Sulcia genome from pooled bacteriomes using a metagenomic approach, yielding a nearly identical genome. Four variations we detected appear to be genuine biological differences between the two samples. Comparison of the single cell genome with bacteriome metagenomic sequence data detected two single nucleotide polymorphisms (SNPs), indicating extremely low genetic diversity within a Sulcia population. This study demonstrates the power of single cell genomics to generate a complete, high quality, non-composite reference genome within an environmental sample, which can be used for population genetic analyzes.« less

A comparative study on generating simulated Landsat NDVI images using data fusion and regression method-the case of the Korean Peninsula.

PubMed

Lee, Mi Hee; Lee, Soo Bong; Eo, Yang Dam; Kim, Sun Woong; Woo, Jung-Hun; Han, Soo Hee

2017-07-01

Landsat optical images have enough spatial and spectral resolution to analyze vegetation growth characteristics. But, the clouds and water vapor degrade the image quality quite often, which limits the availability of usable images for the time series vegetation vitality measurement. To overcome this shortcoming, simulated images are used as an alternative. In this study, weighted average method, spatial and temporal adaptive reflectance fusion model (STARFM) method, and multilinear regression analysis method have been tested to produce simulated Landsat normalized difference vegetation index (NDVI) images of the Korean Peninsula. The test results showed that the weighted average method produced the images most similar to the actual images, provided that the images were available within 1 month before and after the target date. The STARFM method gives good results when the input image date is close to the target date. Careful regional and seasonal consideration is required in selecting input images. During summer season, due to clouds, it is very difficult to get the images close enough to the target date. Multilinear regression analysis gives meaningful results even when the input image date is not so close to the target date. Average R 2 values for weighted average method, STARFM, and multilinear regression analysis were 0.741, 0.70, and 0.61, respectively.

Infrared space astrometry project JASMINE

NASA Astrophysics Data System (ADS)

Gouda, N.; Kobayashi, Y.; Yamada, Y.; Yano, T.; Yano

2008-07-01

A Japanese plan of an infrared (z-band:0.9 μas or k-band:2.2 μas) space astrometry (JASMINE-project) is introduced. JASMINE (Japan Astrometry Satellite Mission for INfrared Exploration) will measure distances and tangential motions of stars in the bulge of the Milky Way. It will measure parallaxes, positions with an accuracy of 10 μas and proper motions with an accuracy of 10 μas/year for stars brighter than z=14 mag or k=11 mag. JASMINE will observe about ten million stars belonging to the bulge component of our Galaxy. With a completely new “map” of the Galactic bulge, it is expected that many new exciting scientific results will be obtained in various fields of astronomy. Presently, JASMINE is in a development phase, with a targeted launch date around 2016. Science targets, preliminary design of instruments, observing strategy, critical technical issues in JASMINE and also Nano-JASMINE project are described in this paper.

Co-occurrent use of cigarettes, alcohol, and caffeine in a retired military population.

PubMed

Talcott, G W; Poston, W S; Haddock, C K

1998-03-01

Previous studies have linked the use of caffeine, nicotine, and alcohol to health complications and have also found that the use of these substances significantly covary. Given the prevalence of health problems of older adults, it is surprising that no studies to date have examined the co-occurrent use of alcohol, caffeine, and nicotine in a senior population. This investigation evaluated the co-occurrent use of cigarettes, caffeine, and alcohol in a community sample of older Americans. Respondents (1,095 women and 1,371 men) completed a questionnaire examining their use of caffeine, nicotine, and alcohol. This study replicated earlier findings that tobacco, caffeine, and alcohol use co-occur and that there are consistent use patterns for these substances. The results suggest that health organizations could better target services by prescreening for smoking, alcohol, and caffeine use and possibly targeting smokers and ex-smokers for potentially problematic use patterns of caffeine and alcohol.

77 FR 20749 - Investment Company Advertising: Target Date Retirement Fund Names and Marketing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

... Names and Marketing AGENCY: Securities and Exchange Commission. ACTION: Proposed rule; reopening of... use of the fund's name in marketing materials; require marketing materials for target date retirement... a statement that would highlight the fund's final asset allocation; require a statement in marketing...

Army Base Realignment Methodology. Volume II.

DTIC Science & Technology

1981-08-01

deficien- cies because they were reconstructed after the fact. c. The Craig action was very similar to the Fort Wolters closure. It was completed ...7 / provided cross-checks on the Fort Wolters After Action Report and substantiated the completion of equipment shipments and proposed construction...DATES AND MILESTONES OF USAMPS RELOCATIONA / Event Date CSJF completed --USAMPS relocation to Fort Devens not justified 22 July 1971 Criminal

Mind-reading accuracy in intimate relationships: assessing the roles of the relationship, the target, and the judge.

PubMed

Thomas, Geoff; Fletcher, Garth J O

2003-12-01

Using a video-review procedure, multiple perceivers carried out mind-reading tasks of multiple targets at different levels of acquaintanceship (50 dating couples, friends of the dating partners, and strangers). As predicted, the authors found that mind-reading accuracy was (a). higher as a function of increased acquaintanceship, (b). relatively unaffected by target effects, (c). influenced by individual differences in perceivers' ability, and (d). higher for female than male perceivers. In addition, superior mind-reading accuracy (for dating couples and friends) was related to higher relationship satisfaction, closeness, and more prior disclosure about the problems discussed, but only under moderating conditions related to sex and relationship length. The authors conclude that the nature of the relationship between the perceiver and the target occupies a pivotal role in determining mind-reading accuracy.

Assessing Date Palm Genetic Diversity Using Different Molecular Markers.

PubMed

Atia, Mohamed A M; Sakr, Mahmoud M; Adawy, Sami S

2017-01-01

Molecular marker technologies which rely on DNA analysis provide powerful tools to assess biodiversity at different levels, i.e., among and within species. A range of different molecular marker techniques have been developed and extensively applied for detecting variability in date palm at the DNA level. Recently, the employment of gene-targeting molecular marker approaches to study biodiversity and genetic variations in many plant species has increased the attention of researchers interested in date palm to carry out phylogenetic studies using these novel marker systems. Molecular markers are good indicators of genetic distances among accessions, because DNA-based markers are neutral in the face of selection. Here we describe the employment of multidisciplinary molecular marker approaches: amplified fragment length polymorphism (AFLP), start codon targeted (SCoT) polymorphism, conserved DNA-derived polymorphism (CDDP), intron-targeted amplified polymorphism (ITAP), simple sequence repeats (SSR), and random amplified polymorphic DNA (RAPD) to assess genetic diversity in date palm.

Sex Role and Dating Orientation.

ERIC Educational Resources Information Center

McCabe, M. P.; Collins, J. K.

1979-01-01

Male and female subjects from three age groups completed questionnaires on sex roles and dating orientations. Males approached dating from both a psychoaffectional and psychobiological orientation, while females approached it from a psychoaffectional orientation. Significant differences were found in dating attitudes between male and female…

Dating conflicts: rethinking dating violence and youth conflict.

PubMed

Adelman, Madelaine; Kil, Sang Hea

2007-12-01

Dating couples are tied to each other's friends who have expectations about dating, such as who constitutes an acceptable date and how to balance friendship and dating. We explore the place of friends in dating conflicts (i.e., conflicts and violence associated with heterosexual teen dating) and ask: (a) How are friends implicated in teen dating/violence not only as targets or confidants, but also as participants in conflict that stems from their friends' relationships, and (b) in what ways do dating conflicts conserve or challenge the power of gender and sexual conformity that underlies heterosexual dating and dating violence?

40 CFR 75.4 - Compliance dates.

Code of Federal Regulations, 2014 CFR

2014-07-01

... relative accuracy test audit (RATA) of the high measurement scale of the monitor is successfully completed... tests required under § 75.20(c) and section 6 of appendix A to this part for the high measurement scale... that all certification tests are completed no later than the following dates (except as provided in...

40 CFR 75.4 - Compliance dates.

Code of Federal Regulations, 2012 CFR

2012-07-01

... relative accuracy test audit (RATA) of the high measurement scale of the monitor is successfully completed... tests required under § 75.20(c) and section 6 of appendix A to this part for the high measurement scale... that all certification tests are completed no later than the following dates (except as provided in...

40 CFR 75.4 - Compliance dates.

Code of Federal Regulations, 2013 CFR

2013-07-01

... relative accuracy test audit (RATA) of the high measurement scale of the monitor is successfully completed... tests required under § 75.20(c) and section 6 of appendix A to this part for the high measurement scale... that all certification tests are completed no later than the following dates (except as provided in...

37 CFR 1.53 - Application number, filing date, and completion of application.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Application number, filing date, and completion of application. 1.53 Section 1.53 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES...

37 CFR 1.53 - Application number, filing date, and completion of application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Application number, filing date, and completion of application. 1.53 Section 1.53 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES...

37 CFR 1.53 - Application number, filing date, and completion of application.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Application number, filing date, and completion of application. 1.53 Section 1.53 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES...

37 CFR 1.53 - Application number, filing date, and completion of application.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Application number, filing date, and completion of application. 1.53 Section 1.53 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES...

37 CFR 1.53 - Application number, filing date, and completion of application.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Application number, filing date, and completion of application. 1.53 Section 1.53 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES...

The effects of the evidence-based Safe Dates dating abuse prevention program on other youth violence outcomes.

PubMed

Foshee, Vangie A; Reyes, Luz McNaughton; Agnew-Brune, Christine B; Simon, Thomas R; Vagi, Kevin J; Lee, Rosalyn D; Suchindran, Chiravath

2014-12-01

In response to recent calls for programs that can prevent multiple types of youth violence, the current study examined whether Safe Dates, an evidence-based dating violence prevention program, was effective in preventing other forms of youth violence. Using data from the original Safe Dates randomized controlled trial, this study examined (1) the effectiveness of Safe Dates in preventing peer violence victimization and perpetration and school weapon carrying 1 year after the intervention phase was completed and (2) moderation of program effects by the sex or race/ethnicity of the adolescent. Ninety percent (n = 1,690) of the eighth and ninth graders who completed baseline questionnaires completed the 1-year follow-up assessment. The sample was 51 % female and 26 % minority (of whom 69 % was black and 31 % was of another minority race/ethnicity). There were no baseline treatment group differences in violence outcomes. Treatment condition was significantly associated with peer violence victimization and school weapon carrying at follow-up; there was 12 % less victimization and 31 % less weapon carrying among those exposed to Safe Dates than those among controls. Treatment condition was significantly associated with perpetration among the minority but not among white adolescents; there was 23 % less violence perpetration among minority adolescents exposed to Safe Dates than that among controls. The observed effect sizes were comparable with those of other universal school-based youth violence prevention programs. Implementing Safe Dates may be an efficient way of preventing multiple types of youth violence.

75 FR 79435 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... functionality by the end of December 2010, it will work with the Commission to set a new target date for... work with the Commission to set a new target date for implementation. The Exchange also has represented...-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate Effectiveness of...

THE PRISM MULTI-OBJECT SURVEY (PRIMUS). II. DATA REDUCTION AND REDSHIFT FITTING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cool, Richard J.; Moustakas, John; Blanton, Michael R.

2013-04-20

The PRIsm MUlti-object Survey (PRIMUS) is a spectroscopic galaxy redshift survey to z {approx} 1 completed with a low-dispersion prism and slitmasks allowing for simultaneous observations of {approx}2500 objects over 0.18 deg{sup 2}. The final PRIMUS catalog includes {approx}130,000 robust redshifts over 9.1 deg{sup 2}. In this paper, we summarize the PRIMUS observational strategy and present the data reduction details used to measure redshifts, redshift precision, and survey completeness. The survey motivation, observational techniques, fields, target selection, slitmask design, and observations are presented in Coil et al. Comparisons to existing higher-resolution spectroscopic measurements show a typical precision of {sigma}{sub z}/(1more » + z) = 0.005. PRIMUS, both in area and number of redshifts, is the largest faint galaxy redshift survey completed to date and is allowing for precise measurements of the relationship between active galactic nuclei and their hosts, the effects of environment on galaxy evolution, and the build up of galactic systems over the latter half of cosmic history.« less

A randomized controlled trial of a multicomponent, targeted, low-literacy educational intervention compared with a nontargeted intervention to boost colorectal cancer screening with fecal immunochemical testing in community clinics.

PubMed

Davis, Stacy N; Christy, Shannon M; Chavarria, Enmanuel A; Abdulla, Rania; Sutton, Steven K; Schmidt, Alyssa R; Vadaparampil, Susan T; Quinn, Gwendolyn P; Simmons, Vani N; Ufondu, Chukwudi B; Ravindra, Chitra; Schultz, Ida; Roetzheim, Richard G; Shibata, David; Meade, Cathy D; Gwede, Clement K

2017-04-15

The objective of the current study was to improve colorectal cancer (CRC) screening uptake with the fecal immunochemical test (FIT). The current study investigated the differential impact of a multicomponent, targeted, low-literacy educational intervention compared with a standard, nontargeted educational intervention. Patients aged 50 to 75 years who were of average CRC risk and not up-to-date with CRC screening were recruited from either a federally qualified health center or a primary care community health clinic. Patients were randomized to the intervention condition (targeted photonovella booklet/DVD plus FIT kit) or comparison condition (standard Centers for Disease Control and Prevention brochure plus FIT kit). The main outcome was screening with FIT within 180 days of delivery of the intervention. Of the 416 participants, 54% were female; the participants were racially and ethnically diverse (66% white, 10% Hispanic, and 28% African American), predominantly of low income, and insured (the majority had county health insurance). Overall, the FIT completion rate was 81%, with 78.1% of participants in the intervention versus 83.5% of those in the comparison condition completing FIT (P =  .17). In multivariate analysis, having health insurance was found to be the primary factor predicting a lack of FIT screening (adjusted odds ratio, 2.10; 95% confidence interval, 1.04-4.26 [P =  .04]). The multicomponent, targeted, low-literacy materials were not found to be significantly different or more effective in increasing FIT uptake compared with the nontargeted materials. Provision of a FIT test plus education may provide a key impetus to improve the completion of CRC screening. The type of educational material (targeted vs nontargeted) may matter less. The findings of the current study provide a unique opportunity for clinics to adopt FIT and to choose the type of patient education materials based on clinic, provider, and patient preferences. Cancer 2017;123:1390-1400. © 2016 American Cancer Society. © 2016 American Cancer Society.

Validation of reference materials for uranium radiochronometry in the frame of nuclear forensic investigations

DOE PAGES

Varga, Z.; Mayer, K.; Bonamici, C. E.; ...

2015-05-11

The results of a joint effort by expert nuclear forensic laboratories in the area of age dating of uranium, i.e. the elapsed time since the last chemical purification of the material are presented and discussed. Completely separated uranium materials of known production date were distributed among the laboratories, and the samples were dated according to routine laboratory procedures by the measurement of the ²²⁰Th/²³⁴U ratio. The measurement results were in good agreement with the known production date showing that the concept for preparing uranium age dating reference material based on complete separation is valid. Detailed knowledge of the laboratory proceduresmore » used for uranium age dating allows the identification of possible improvements in the current protocols and the development of improved practice in the future. The availability of age dating reference materials as well as the evolvement of the age dating best-practice protocol will increase the relevance and applicability of age dating as part of the tool-kit available for nuclear forensic investigations.« less

Validation of reference materials for uranium radiochronometry in the frame of nuclear forensic investigations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Varga, Z.; Mayer, K.; Bonamici, C. E.

The results of a joint effort by expert nuclear forensic laboratories in the area of age dating of uranium, i.e. the elapsed time since the last chemical purification of the material are presented and discussed. Completely separated uranium materials of known production date were distributed among the laboratories, and the samples were dated according to routine laboratory procedures by the measurement of the ²²⁰Th/²³⁴U ratio. The measurement results were in good agreement with the known production date showing that the concept for preparing uranium age dating reference material based on complete separation is valid. Detailed knowledge of the laboratory proceduresmore » used for uranium age dating allows the identification of possible improvements in the current protocols and the development of improved practice in the future. The availability of age dating reference materials as well as the evolvement of the age dating best-practice protocol will increase the relevance and applicability of age dating as part of the tool-kit available for nuclear forensic investigations.« less

Sparse Representation for Infrared Dim Target Detection via a Discriminative Over-Complete Dictionary Learned Online

PubMed Central

Li, Zheng-Zhou; Chen, Jing; Hou, Qian; Fu, Hong-Xia; Dai, Zhen; Jin, Gang; Li, Ru-Zhang; Liu, Chang-Ju

2014-01-01

It is difficult for structural over-complete dictionaries such as the Gabor function and discriminative over-complete dictionary, which are learned offline and classified manually, to represent natural images with the goal of ideal sparseness and to enhance the difference between background clutter and target signals. This paper proposes an infrared dim target detection approach based on sparse representation on a discriminative over-complete dictionary. An adaptive morphological over-complete dictionary is trained and constructed online according to the content of infrared image by K-singular value decomposition (K-SVD) algorithm. Then the adaptive morphological over-complete dictionary is divided automatically into a target over-complete dictionary describing target signals, and a background over-complete dictionary embedding background by the criteria that the atoms in the target over-complete dictionary could be decomposed more sparsely based on a Gaussian over-complete dictionary than the one in the background over-complete dictionary. This discriminative over-complete dictionary can not only capture significant features of background clutter and dim targets better than a structural over-complete dictionary, but also strengthens the sparse feature difference between background and target more efficiently than a discriminative over-complete dictionary learned offline and classified manually. The target and background clutter can be sparsely decomposed over their corresponding over-complete dictionaries, yet couldn't be sparsely decomposed based on their opposite over-complete dictionary, so their residuals after reconstruction by the prescribed number of target and background atoms differ very visibly. Some experiments are included and the results show that this proposed approach could not only improve the sparsity more efficiently, but also enhance the performance of small target detection more effectively. PMID:24871988

Sparse representation for infrared Dim target detection via a discriminative over-complete dictionary learned online.

PubMed

Li, Zheng-Zhou; Chen, Jing; Hou, Qian; Fu, Hong-Xia; Dai, Zhen; Jin, Gang; Li, Ru-Zhang; Liu, Chang-Ju

2014-05-27

It is difficult for structural over-complete dictionaries such as the Gabor function and discriminative over-complete dictionary, which are learned offline and classified manually, to represent natural images with the goal of ideal sparseness and to enhance the difference between background clutter and target signals. This paper proposes an infrared dim target detection approach based on sparse representation on a discriminative over-complete dictionary. An adaptive morphological over-complete dictionary is trained and constructed online according to the content of infrared image by K-singular value decomposition (K-SVD) algorithm. Then the adaptive morphological over-complete dictionary is divided automatically into a target over-complete dictionary describing target signals, and a background over-complete dictionary embedding background by the criteria that the atoms in the target over-complete dictionary could be decomposed more sparsely based on a Gaussian over-complete dictionary than the one in the background over-complete dictionary. This discriminative over-complete dictionary can not only capture significant features of background clutter and dim targets better than a structural over-complete dictionary, but also strengthens the sparse feature difference between background and target more efficiently than a discriminative over-complete dictionary learned offline and classified manually. The target and background clutter can be sparsely decomposed over their corresponding over-complete dictionaries, yet couldn't be sparsely decomposed based on their opposite over-complete dictionary, so their residuals after reconstruction by the prescribed number of target and background atoms differ very visibly. Some experiments are included and the results show that this proposed approach could not only improve the sparsity more efficiently, but also enhance the performance of small target detection more effectively.

20 CFR 655.533 - What should be submitted for locations in Alaska?

Code of Federal Regulations, 2010 CFR

2010-04-01

... locations in Alaska? (a) Form ETA 9033-A with accompanying documentation. A completed and dated original Form ETA 9033-A, or facsimile transmission thereof, containing the required attestation elements and... with two copies of the completed, signed, and dated Form ETA 9033-A shall be submitted to ETA. (If the...

40 CFR 68.170 - Prevention program/Program 2.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the process. (c) The name(s) of the chemical(s) covered. (d) The date of the most recent review or... (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.170 Prevention program/Program... of completion of the most recent hazard review or update. (1) The expected date of completion of any...

40 CFR 68.170 - Prevention program/Program 2.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the process. (c) The name(s) of the chemical(s) covered. (d) The date of the most recent review or... (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.170 Prevention program/Program... of completion of the most recent hazard review or update. (1) The expected date of completion of any...

40 CFR 68.170 - Prevention program/Program 2.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the process. (c) The name(s) of the chemical(s) covered. (d) The date of the most recent review or... (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.170 Prevention program/Program... of completion of the most recent hazard review or update. (1) The expected date of completion of any...

29 CFR 95.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... to make the property usable for the purpose for which it was acquired. Other charges, such as the... required work of the award have been completed by the recipient and DOL. (h) Commercial organization means... project or program costs not borne by DOL. (k) Date of completion means the date on which all work under...

20 CFR 404.630 - Use of date of written statement as filing date.

Code of Federal Regulations, 2014 CFR

2014-04-01

... contacts us through the Internet by completing and transmitting the Personal Identification Information data on the Internet Social Security Benefit Application to us, we will use the date of the... date. 404.630 Section 404.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE...

20 CFR 404.630 - Use of date of written statement as filing date.

Code of Federal Regulations, 2010 CFR

2010-04-01

... contacts us through the Internet by completing and transmitting the Personal Identification Information data on the Internet Social Security Benefit Application to us, we will use the date of the... date. 404.630 Section 404.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE...

20 CFR 404.630 - Use of date of written statement as filing date.

Code of Federal Regulations, 2012 CFR

2012-04-01

... contacts us through the Internet by completing and transmitting the Personal Identification Information data on the Internet Social Security Benefit Application to us, we will use the date of the... date. 404.630 Section 404.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE...

20 CFR 404.630 - Use of date of written statement as filing date.

Code of Federal Regulations, 2013 CFR

2013-04-01

... contacts us through the Internet by completing and transmitting the Personal Identification Information data on the Internet Social Security Benefit Application to us, we will use the date of the... date. 404.630 Section 404.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE...

Engineering and environmental remediation scenarios due to leakage from the Gulf War oil spill using 3-D numerical contaminant modellings

NASA Astrophysics Data System (ADS)

Yihdego, Yohannes; Al-Weshah, Radwan A.

2017-11-01

The transport groundwater modelling has been undertaken to assess potential remediation scenarios and provide an optimal remediation options for consideration. The purpose of the study was to allow 50 years of predictive remediation simulation time. The results depict the likely total petroleum hydrocarbon migration pattern in the area under the worst-case scenario. The remediation scenario simulations indicate that do nothing approach will likely not achieve the target water quality within 50 years. Similarly, complete source removal approach will also likely not achieve the target water quality within 50 years. Partial source removal could be expected to remove a significant portion of the contaminant mass, but would increase the rate of contaminant recharge in the short to medium term. The pump-treat-reinject simulation indicates that the option appears feasible and could achieve a reduction in the area of the 0.01 mg/L TPH contour area for both Raudhatain and Umm Al-Aish by 35 and 30%, respectively, within 50 years. The rate of improvement and the completion date would depend on a range of factors such as bore field arrangements, pumping rates, reinjection water quality and additional volumes being introduced and require further optimisation and field pilot trials.

Psychiatric and Cognitive Functioning in Adolescent Inpatients with Histories of Dating Violence Victimization

PubMed Central

Rizzo, Christie J.; Esposito-Smythers, Christianne; Spirito, Anthony; Thompson, Ariel

2010-01-01

The presence of dating violence victimization as well as its relation to psychiatric diagnosis and cognitive processes was examined in a sample of 155 adolescents hospitalized in a psychiatric facility. Participants and their parents completed semi-structured diagnostic interviews. Participants also completed self-report measures of dating violence victimization and cognitive functioning. Seventy-seven percent of adolescents who had initiated dating reported psychological, physical, and/or sexual abuse by a dating partner over the past year. Victims of psychological abuse alone as well as physical and/or sexual violence endorsed higher rates of major depressive disorder compared to non-victims. Physical/sexual dating violence victims also endorsed significantly higher rates of PTSD and alcohol use disorders, more frequent co-occurrence of externalizing and internalizing disorders, and more frequent negative cognitive biases, relative to non-victimized adolescents. Findings suggest that psychiatrically hospitalized adolescents with dating violence histories represent a subgroup of adolescent inpatients with a particularly serious clinical picture. PMID:20824193

Liver as a target for oligonucleotide therapeutics.

PubMed

Sehgal, Alfica; Vaishnaw, Akshay; Fitzgerald, Kevin

2013-12-01

Oligonucleotide-based therapeutics are an emerging class of drugs that hold the promise for silencing "un-druggable" targets,thus creating unique opportunities for innovative medicines. As opposed to gene therapy, oligonucleotides are considered to be more akin to small molecule therapeutics because they are small,completely synthetic in origin, do not integrate into the host genome,and have a defined duration of therapeutic activity after which effects recover to baseline. They offer a high degree of specificity at the genetic level, thereby reducing off-target effects.At the same time, they provide a strategy for targeting any gene in the genome, including transcripts that produce mutated proteins.Oligonucleotide-based therapeutics include short interfering RNA (siRNA), that degrade target mRNA through RISC mediated RNAi; anti-miRs, that target miRNAs; miRNA mimics, that regulate target mRNA; antisense oligonucleotides, that may be working through RNAseH mediated mRNA decay; mRNA upregulation,by targeting long non-coding RNAs; and oligonucleotides induced alternative splicing [1]. All these approaches require some minimal degree of homology at the nucleic acid sequence level for them to be functional. The different mechanisms of action and their relevant activity are outlined in Fig. 1. Besides homology,RNA secondary structure has also been exploited in the case of ribozymes and aptamers, which act by binding to nucleic acids or proteins, respectively. While there have been many reports of gene knockdown and gene modulation in cell lines and mice with all these methods, very few have advanced to clinical stages.The main obstacle to date has been the safe and effective intracellular delivery of these compounds in higher species, including humans. Indeed, their action requires direct interaction with DNA/RNA within the target cell so even when one solves the issues of tissue and cellular access, intracellular/intranuclear location represents yet another barrier to overcome. To date,hepatic delivery of oligonucleotides has been the area with greatest progress, and thus we have focused on liver-targeted therapeutics that have shown promise at the preclinical and/or clinical level.The liver is the largest internal organ in the body, playing a central role in metabolism, detoxification, synthesis, and secretion of major plasma proteins (carrier proteins, coagulation factors,complement components, hormones, and apolipoproteins),and iron homeostasis. It is therefore not surprising that a large number of disease targets reside in the liver where they are susceptible to modulation by oligonucleotide therapies.

An Evaluation of a Mixed-Gender Date Rape Prevention Workshop.

ERIC Educational Resources Information Center

Holcomb, Derek R.; And Others

1993-01-01

Compared date rape attitudes in college students who did and did not complete a mixed-gender date rape workshop. Survey results indicated men were more tolerant of date rape than women; control group students were more tolerant than treatment group students; and men exhibited a greater program effect than women. (SM)

20 CFR 418.3230 - When will we use your subsidy inquiry as your filing date?

Code of Federal Regulations, 2012 CFR

2012-04-01

... filing date? 418.3230 Section 418.3230 Employees' Benefits SOCIAL SECURITY ADMINISTRATION MEDICARE... oral or written inquiry about the subsidy, or partially complete an Internet subsidy application on our Web site, we will use the date of the inquiry or the date the partial Internet application was started...

20 CFR 418.3230 - When will we use your subsidy inquiry as your filing date?

Code of Federal Regulations, 2014 CFR

2014-04-01

... filing date? 418.3230 Section 418.3230 Employees' Benefits SOCIAL SECURITY ADMINISTRATION MEDICARE... oral or written inquiry about the subsidy, or partially complete an Internet subsidy application on our Web site, we will use the date of the inquiry or the date the partial Internet application was started...

20 CFR 418.3230 - When will we use your subsidy inquiry as your filing date?

Code of Federal Regulations, 2013 CFR

2013-04-01

... filing date? 418.3230 Section 418.3230 Employees' Benefits SOCIAL SECURITY ADMINISTRATION MEDICARE... oral or written inquiry about the subsidy, or partially complete an Internet subsidy application on our Web site, we will use the date of the inquiry or the date the partial Internet application was started...

Social Support as a Moderator between Dating Violence Victimization and Depression/Anxiety among African American and Caucasian Adolescents

ERIC Educational Resources Information Center

Holt, Melissa K.; Espelage, Dorothy L.

2005-01-01

Victimization in dating relationships was examined among 681 African American and Caucasian adolescents. Specifically, perceived social support was evaluated as a moderator between (a) physical dating violence victimization and anxiety/depression and (b) emotional abuse in dating relationships and anxiety/depression. Youth completed self-report…

75 FR 27643 - Prevention of Significant Deterioration (PSD) and Nonattainment New Source Review (NSR): Aggregation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... (APA) section 705 until the proceeding for judicial review of this rule is completed or EPA completes... section 705 of the APA, ``an agency * * * may postpone the effective date of [an] action taken by it... and Delay of Effective Date Pursuant to section 705 of the APA, the EPA hereby postpones the...

77 FR 39924 - Effective Date of Requirement for Premarket Approval for Cardiovascular Permanent Pacemaker...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

.... FDA-2011-N-0505] Effective Date of Requirement for Premarket Approval for Cardiovascular Permanent... application (PMA) or a notice of completion of a product development protocol (PDP) for the cardiovascular...) of the FD&C Act of a PMA or notice of completion of a PDP for the cardiovascular permanent pacemaker...

75 FR 79427 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... end of December 2010, it will work with the Commission to set a new target date for implementation as... new target date for implementation. The Exchange also has represented that it plans to file a proposed... made to the rules of New York Stock Exchange LLC. See SR-NYSE-2010- 79. \\6\\ See Securities Exchange Act...

The Associations between Substance Use, Sexual Behaviors, Bullying, Deviant Behaviors, Health, and Cyber Dating Abuse Perpetration

ERIC Educational Resources Information Center

Van Ouytsel, Joris; Torres, Elizabeth; Choi, Hye Jeong; Ponnet, Koen; Walrave, Michel; Temple, Jeff R.

2017-01-01

Dating violence is an important public health concern and is considered to be a form of school violence. While digital technologies have enabled perpetrators of dating violence to target their victims online (cyber dating abuse), little is known about how this form of perpetration relates to specific adolescent risk behaviors. This brief research…

26 CFR 1.336-1 - General principles, nomenclature, and definitions for a section 336(e) election.

Code of Federal Regulations, 2014 CFR

2014-04-01

... transferee and a distributee of target stock. (3) Target; S corporation target; old target; new target. The... before the close of target's disposition date and new target refers to target for subsequent periods. In... combination thereof, five percent or more, by value, of the stock of target in the qualified stock disposition...

Evidence-based treatments for low sexual desire in women.

PubMed

Brotto, Lori A

2017-04-01

Low sexual desire is the most common sexual complaint in women, with multinational studies finding that at least a third of women experience low sexual desire. No single etiology for the development of Female Sexual Interest/Arousal Disorder, the diagnosis laid out by the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders, has been established. There has been considerable interest in pharmacological approaches to improving low desire, and agents targeting a range of neurotransmitters have been examined. To date, only flibanserin, a centrally acting medication targeting the serotonin, dopamine, and norepinephrine systems, has been approved by the Food and Drug Administration (FDA). Despite statistically significant effects on sexual desire, sexual distress, and sexually satisfying events, side-effects are significant, and flibanserin is completely contraindicated with alcohol. As such, there has been renewed interest in advancing the science of psychological approaches to low desire, including cognitive behavioral and mindfulness therapies. Copyright © 2017 Elsevier Inc. All rights reserved.

Lower Limits on Aperture Size for an ExoEarth Detecting Coronagraphic Mission

NASA Technical Reports Server (NTRS)

Stark, Christopher C.; Roberge, Aki; Mandell, Avi; Clampin, Mark; Domagal-Goldman, Shawn D.; McElwain, Michael W.; Stapelfeldt, Karl R.

2015-01-01

The yield of Earth-like planets will likely be a primary science metric for future space-based missions that will drive telescope aperture size. Maximizing the exoEarth candidate yield is therefore critical to minimizing the required aperture. Here we describe a method for exoEarth candidate yield maximization that simultaneously optimizes, for the first time, the targets chosen for observation, the number of visits to each target, the delay time between visits, and the exposure time of every observation. This code calculates both the detection time and multiwavelength spectral characterization time required for planets. We also refine the astrophysical assumptions used as inputs to these calculations, relying on published estimates of planetary occurrence rates as well as theoretical and observational constraints on terrestrial planet sizes and classical habitable zones. Given these astrophysical assumptions, optimistic telescope and instrument assumptions, and our new completeness code that produces the highest yields to date, we suggest lower limits on the aperture size required to detect and characterize a statistically motivated sample of exoEarths.

Activity targets for nanostructured platinum-group-metal-free catalysts in hydroxide exchange membrane fuel cells.

PubMed

Setzler, Brian P; Zhuang, Zhongbin; Wittkopf, Jarrid A; Yan, Yushan

2016-12-06

Fuel cells are the zero-emission automotive power source that best preserves the advantages of gasoline automobiles: low upfront cost, long driving range and fast refuelling. To make fuel-cell cars a reality, the US Department of Energy has set a fuel cell system cost target of US$30 kW -1 in the long-term, which equates to US$2,400 per vehicle, excluding several major powertrain components (in comparison, a basic, but complete, internal combustion engine system costs approximately US$3,000). To date, most research for automotive applications has focused on proton exchange membrane fuel cells (PEMFCs), because these systems have demonstrated the highest power density. Recently, however, an alternative technology, hydroxide exchange membrane fuel cells (HEMFCs), has gained significant attention, because of the possibility to use stable platinum-group-metal-free catalysts, with inherent, long-term cost advantages. In this Perspective, we discuss the cost profile of PEMFCs and the advantages offered by HEMFCs. In particular, we discuss catalyst development needs for HEMFCs and set catalyst activity targets to achieve performance parity with state-of-the-art automotive PEMFCs. Meeting these targets requires careful optimization of nanostructures to pack high surface areas into a small volume, while maintaining high area-specific activity and favourable pore-transport properties.

Activity targets for nanostructured platinum-group-metal-free catalysts in hydroxide exchange membrane fuel cells

NASA Astrophysics Data System (ADS)

Setzler, Brian P.; Zhuang, Zhongbin; Wittkopf, Jarrid A.; Yan, Yushan

2016-12-01

Fuel cells are the zero-emission automotive power source that best preserves the advantages of gasoline automobiles: low upfront cost, long driving range and fast refuelling. To make fuel-cell cars a reality, the US Department of Energy has set a fuel cell system cost target of US$30 kW-1 in the long-term, which equates to US$2,400 per vehicle, excluding several major powertrain components (in comparison, a basic, but complete, internal combustion engine system costs approximately US$3,000). To date, most research for automotive applications has focused on proton exchange membrane fuel cells (PEMFCs), because these systems have demonstrated the highest power density. Recently, however, an alternative technology, hydroxide exchange membrane fuel cells (HEMFCs), has gained significant attention, because of the possibility to use stable platinum-group-metal-free catalysts, with inherent, long-term cost advantages. In this Perspective, we discuss the cost profile of PEMFCs and the advantages offered by HEMFCs. In particular, we discuss catalyst development needs for HEMFCs and set catalyst activity targets to achieve performance parity with state-of-the-art automotive PEMFCs. Meeting these targets requires careful optimization of nanostructures to pack high surface areas into a small volume, while maintaining high area-specific activity and favourable pore-transport properties.

Stability of alcohol use and teen dating violence for female youth: A latent transition analysis.

PubMed

Choi, Hye Jeong; Elmquist, JoAnna; Shorey, Ryan C; Rothman, Emily F; Stuart, Gregory L; Temple, Jeff R

2017-01-01

Alcohol use is one of the most widely accepted and studied risk factors for teen dating violence (TDV). Too little research has explored longitudinally if it is true that an adolescent's alcohol use and TDV involvement simultaneously occur. In the current study, we examined whether there were latent status based on past-year TDV and alcohol use and whether female adolescents changed their statuses of TDV and alcohol use over time. The sample consisted of 583 female youths in seven public high schools in Texas. Three waves of longitudinal data collected from 2011 to 2013 were utilised in this study. Participants completed self-report assessments of alcohol use (past-year alcohol use, number of drinks in the past month and episodic heavy drinking within the past month) and psychological and physical TDV victimisation and perpetration. Latent transition analysis was used to examine if the latent status based on TDV and alcohol use changed over time. Five separate latent statuses were identified: (i) no violence, no alcohol; (ii) alcohol; (iii) psychological violence, no alcohol; (iv) psychological violence, alcohol; and (v) physical and psychological violence, alcohol. Latent transition analysis indicated that adolescents generally remained in the same subgroup across time. This study provides evidence on the co-occurrence of alcohol use and teen dating violence, and whether teens' status based on dating violence and alcohol use are stable over time. Findings from the current study highlight the importance of targeting both TDV and substance use in intervention and prevention programs. [Choi HJ, Elmquist J, Shorey RC, Rothman EF, Stuart GL,Temple JR. Stability of alcohol use and teen dating violence for female youth: Alatent transition analysis. Drug Alcohol Rev 2017;36:80-87]. © 2017 Australasian Professional Society on Alcohol and other Drugs.

Charting the complete elastic properties of inorganic crystalline compounds

PubMed Central

de Jong, Maarten; Chen, Wei; Angsten, Thomas; Jain, Anubhav; Notestine, Randy; Gamst, Anthony; Sluiter, Marcel; Krishna Ande, Chaitanya; van der Zwaag, Sybrand; Plata, Jose J; Toher, Cormac; Curtarolo, Stefano; Ceder, Gerbrand; Persson, Kristin A.; Asta, Mark

2015-01-01

The elastic constant tensor of an inorganic compound provides a complete description of the response of the material to external stresses in the elastic limit. It thus provides fundamental insight into the nature of the bonding in the material, and it is known to correlate with many mechanical properties. Despite the importance of the elastic constant tensor, it has been measured for a very small fraction of all known inorganic compounds, a situation that limits the ability of materials scientists to develop new materials with targeted mechanical responses. To address this deficiency, we present here the largest database of calculated elastic properties for inorganic compounds to date. The database currently contains full elastic information for 1,181 inorganic compounds, and this number is growing steadily. The methods used to develop the database are described, as are results of tests that establish the accuracy of the data. In addition, we document the database format and describe the different ways it can be accessed and analyzed in efforts related to materials discovery and design. PMID:25984348

Safe Sex Messages Within Dating and Entertainment Smartphone Apps: A Review

PubMed Central

Williams, Henrietta; Hocking, Jane S; Lim, Megan SC

2016-01-01

Background Smartphone apps provide a new platform for entertainment, information distribution, and health promotion activities, as well as for dating and casual sexual encounters. Previous research has shown high acceptability of sexual health interventions via smartphone apps; however, sexual health promotion apps were infrequently downloaded and underused. Integrating sexual health promotion into established apps might be a more effective method. Objective The objective of our study was to critically review popular sex-related apps and dating apps, in order to ascertain whether they contain any sexual health content. Methods Part 1: In January 2015, we used the term “sexual” to search for free apps in the Apple iTunes store and Android Google Play store, and categorized the sexual health content of the 137 apps identified. Part 2: We used the term “dating” to search for free geosocial-networking apps in the Apple iTunes and Android Google Play stores. The apps were downloaded to test functionality and to determine whether they included sexual health content. Results Part 1: Of the 137 apps identified, 15 (11.0%) had sexual health content and 15 (11.0%) contained messages about sexual assault or violence. The majority of the apps did not contain any sexual health content. Part 2: We reviewed 60 dating apps: 44 (73%) targeting heterosexual users, 9 (15%) targeting men who have sex with men (MSM), 3 (5%) targeting lesbian women, and 4 (7%) for group dating. Only 9 dating apps contained sexual health content, of which 7 targeted MSM. Conclusions The majority of sex-related apps and dating apps contained no sexual health content that could educate users about and remind them of their sexual risks. Sexual health practitioners and public health departments will need to work with app developers to promote sexual health within existing popular apps. For those apps that already contain sexual health messages, further study to investigate the effectiveness of the content is needed. PMID:27826133

Artifacts in Radar Imaging of Moving Targets

DTIC Science & Technology

2012-09-01

CA, USA, 2007. [11] B. Borden, Radar imaging of airborne targets: A primer for Applied mathematicians and Physicists . New York, NY: Taylor and... Project (0704–0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE 21 September 2012 3. REPORT TYPE AND DATES COVERED...CW Continuous Wave DAC Digital to Analog Convertor DFT Discrete Fourier Transform FBP Filtered Back Projection FFT Fast Fourier Transform GPS

Getting right to the point: identifying Australian outpatients' priorities and preferences for patient-centred quality improvement in chronic disease care.

PubMed

Fradgley, Elizabeth A; Paul, Christine L; Bryant, Jamie; Oldmeadow, Christopher

2016-09-01

To identify specific actions for patient-centred quality improvement in chronic disease outpatient settings, this study identified patients' general and specific preferences among a comprehensive suite of initiatives for change. A cross-sectional survey was conducted in three hospital-based clinics specializing in oncology, neurology and cardiology care located in New South Wales, Australia. Adult English-speaking outpatients completed the touch-screen Consumer Preferences Survey in waiting rooms or treatment areas. Participants selected up to 23 general initiatives that would improve their experience. Using adaptive branching, participants could select an additional 110 detailed initiatives and complete a relative prioritization exercise. A total of 541 individuals completed the survey (71.1% consent, 73.1% completion). Commonly selected general initiatives, presented in order of decreasing priority (along with sample proportion), included: improved parking (60.3%), up-to-date information provision (15.0%), ease of clinic contact (12.9%), access to information at home (12.8%), convenient appointment scheduling (14.2%), reduced wait-times (19.8%) and information on medical emergencies (11.1%). To address these general initiatives, 40 detailed initiatives were selected by respondents. Initiatives targeting service accessibility and information provision, such as parking and up-to-date information on patient prognoses and progress, were commonly selected and perceived to be of relatively greater priority. Specific preferences included the need for clinics to provide patient-designated parking in close proximity to the clinic, information on treatment progress and test results (potentially in the form of designated brief appointments or via telehealth) and comprehensive and trustworthy lists of information sources to access at home. © The Author 2016. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Drinking and Dating: Examining the Link among Relationship Satisfaction, Hazardous Drinking, and Readiness-to-Change in College Dating Relationships

ERIC Educational Resources Information Center

Khaddouma, Alexander; Shorey, Ryan C.; Brasfield, Hope; Febres, Jeniimarie; Zapor, Heather; Elmquist, Joanna; Stuart, Gregory L.

2016-01-01

For this study we examined the association between relationship satisfaction and readiness-to-change alcohol use, as well as the associations between hazardous drinking and readiness-to-change relationship issues in college dating relationships. A sample of 219 college students in a current dating relationship (aged 18-25) completed self-report…

Effect of date seeds on oxidative damage and antioxidant status in vivo.

PubMed

Habib, Hosam M; Ibrahim, Wissam H

2011-07-01

Date seeds have been shown to contain high amounts of antioxidants. However, in vivo studies on date seeds are lacking. Therefore the purpose of this study was to determine the effect of date seeds on oxidative damage and antioxidant status in vivo. Male Wistar rats were fed a basal diet containing 0, 70 or 140 g kg(-1) date seeds for 30 days. All three diets were isonitrogenous and isocaloric. Indication of oxidative damage was assessed in the liver and serum, and antioxidant status was assessed in the liver. Serum biochemical parameters, including indicators of tissue cellular damage and complete blood count with differential, were also determined. The results showed that date seeds significantly (P<0.05) reduced liver and serum malondialdehyde (a lipid peroxidative damage product) and serum lactate dehydrogenase and creatine kinase. Liver antioxidants (vitamin E, vitamin C, glutathione, superoxide dismutase, glutathione peroxidase and catalase), complete blood count with differential and other serum biochemical parameters assessed were not significantly altered by date seeds. The results obtained suggest a protective effect of date seeds against in vivo oxidative damage, possibly through the action of their bioactive antioxidants. Copyright © 2011 Society of Chemical Industry.

Quantitative spectroscopic analyses in the IACOB+OWN project: Massive O-type stars in the Galaxy with the current Gaia information

NASA Astrophysics Data System (ADS)

Holgado, Gonzalo; Simón-Díaz, Sergio; Barbá, Rodolfo

2017-11-01

We present the results from the quantitative spectroscopic analysis of ~280 likely single O stars targeted by the IACOB and OWN surveys. This implies the largest sample of Galactic O-type stars analyzed homogeneously to date. We used the iacob-broad and iacob-gbat tools (see Simón-Díaz et al. 2011,2015) to obtain the complete set of spectroscopic parameters which can be determined from the optical spectrum of O-type stars: projected rotational velocity (v sin i), macroturbulence velocity (v mac), effective temperature (T eff), gravity (logg), wind-strength (logQ), helium abundance (Y He), microturbulence (ξt), and the exponent of the wind-law (β).

Supersonics--Airport Noise

NASA Technical Reports Server (NTRS)

Bridges, James

2007-01-01

At this, the first year-end meeting of the Fundamental Aeronautics Program, an overview of the Airport Noise discipline of the Supersonics Project leads the presentation of technical plans and achievements in this area of the Project. The overview starts by defining the Technical Challenges targeted by Airport Noise efforts, and the Approaches planned to meet these challenges. These are fleshed out in Elements, namely Prediction, Diagnostics, and Engineering, and broken down into Tasks. The Tasks level is where individual researchers' work is defined and from whence the technical presentations to follow this presentation come. This overview also presents the Milestones accomplished to date and to be completed in the next year. Finally, the NASA Research Announcement cooperative agreement activities are covered and tied to the Tasks and Milestones.

KSC-08pd0074

NASA Image and Video Library

2008-01-17

KENNEDY SPACE CENTER, FLA. -- On Launch Pad 39A at NASA's Kennedy Space Center, a technician completes installing the cover over the engine cutoff, or ECO, sensor system connector and wiring on space shuttle Atlantis' external tank. The feed-through connector passes the wires from the inside of the tank to the outside. Results of a tanking test on Dec. 18 pointed to an open circuit in the feed-through connector wiring, which is located at the base of the tank. The pins in the replacement connector were precisely soldered to create a connection that allows sensors inside the tank to send signals to the computers onboard Atlantis. The launch date for the shuttle's STS-122 mission has now been targeted for Feb. 7. Photo credit: NASA/Kim Shiflett

12 CFR Appendix A to Part 203 - Form and Instructions for Completion of HMDA Loan/Application Register

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 2 2011-01-01 2011-01-01 false Form and Instructions for Completion of HMDA..., numerals, or a combination of both. 2. Date Application Received a. Enter the date the loan application was... (any loan other than FHA, VA, FSA, or RHS loans) Code 2—FHA-insured (Federal Housing Administration...

76 FR 50663 - Effective Date of Requirement for Premarket Approval for Three Class III Preamendments Devices

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-16

... completion of a PDP is not filed by the latter of the two dates, and no IDE is in effect, the device is... availability of a preamendments class III devices strategy document. The strategy document set forth FDA's... approved PMA or a declared completed PDP is required to be in effect for any such devices on or before 180...

49 CFR 381.510 - May the FMCSA end a pilot program before its scheduled completion date?

Code of Federal Regulations, 2010 CFR

2010-10-01

... achieving a level of safety that is at least equivalent to the level of safety that would be achieved by... 49 Transportation 5 2010-10-01 2010-10-01 false May the FMCSA end a pilot program before its... Pilot Programs § 381.510 May the FMCSA end a pilot program before its scheduled completion date? The...

Apoptosis Induction by Targeting Interferon Gamma Receptor 2 (IFNgammaR2) in Prostate Cancer: Ligand (IFNgamma) Independent Novel Function of IFNgammaR2 as a Bax Inhibitor

DTIC Science & Technology

2016-10-01

DATE October 2016 2. REPORT TYPE Final report 3 . DATES COVERED 1 Aug 2012 - 31 Jul 2016 4. TITLE AND SUBTITLE Apoptosis Induction by Targeting...identify the subtype of prostate cancer that can be effectively treated by IFNγR2-targeting technologies (Months 13-36) Task 3 : Determination of the...N-terminal 53 amino acids is known to be auto-inhibitory domain that keeps Bax in the cytosol[ 3 ]. If this domain is cleaved, Bax is known to be

77 FR 25010 - Hawaii Disaster # HI-00026

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-26

.../18/2012. Incident: Severe Storms, Flooding, and Landslides. Incident Period: 03/03/2012 through 03/11/2012. Effective Date: 04/18/2012. Physical Loan Application Deadline Date: 06/18/2012. Economic Injury (EIDL) Loan Application Deadline Date: 01/18/2013. ADDRESSES: Submit completed loan applications to: U.S...

Safe Sex Messages Within Dating and Entertainment Smartphone Apps: A Review.

PubMed

Huang, Evelyn Tzu-Yen; Williams, Henrietta; Hocking, Jane S; Lim, Megan Sc

2016-11-08

Smartphone apps provide a new platform for entertainment, information distribution, and health promotion activities, as well as for dating and casual sexual encounters. Previous research has shown high acceptability of sexual health interventions via smartphone apps; however, sexual health promotion apps were infrequently downloaded and underused. Integrating sexual health promotion into established apps might be a more effective method. The objective of our study was to critically review popular sex-related apps and dating apps, in order to ascertain whether they contain any sexual health content. Part 1: In January 2015, we used the term "sexual" to search for free apps in the Apple iTunes store and Android Google Play store, and categorized the sexual health content of the 137 apps identified. Part 2: We used the term "dating" to search for free geosocial-networking apps in the Apple iTunes and Android Google Play stores. The apps were downloaded to test functionality and to determine whether they included sexual health content. Part 1: Of the 137 apps identified, 15 (11.0%) had sexual health content and 15 (11.0%) contained messages about sexual assault or violence. The majority of the apps did not contain any sexual health content. Part 2: We reviewed 60 dating apps: 44 (73%) targeting heterosexual users, 9 (15%) targeting men who have sex with men (MSM), 3 (5%) targeting lesbian women, and 4 (7%) for group dating. Only 9 dating apps contained sexual health content, of which 7 targeted MSM. The majority of sex-related apps and dating apps contained no sexual health content that could educate users about and remind them of their sexual risks. Sexual health practitioners and public health departments will need to work with app developers to promote sexual health within existing popular apps. For those apps that already contain sexual health messages, further study to investigate the effectiveness of the content is needed. ©Evelyn Tzu-Yen Huang, Henrietta Williams, Jane S Hocking, Megan SC Lim. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 08.11.2016.

Magdalena Ridge Observatory Interferometer - New Path to First Light

NASA Astrophysics Data System (ADS)

Creech-Eakman, Michelle J.; Payne, Ifan; Haniff, Chris; Buscher, David; Young, John; Romero, Van; Magdalena Ridge Observatory Interferometer Team

2016-01-01

The Magdalena Ridge Observatory Interferometer (MROI), a 10-telescope optical/near-IR interferometer with baselines ranging from 7.8 to 343 meters, has been conceived to be the most ambitious optical/NIR interferometric array under construction to date. U.S. Congressional, N.M. State and university funding (from NM Tech and partner funding at the University of Cambridge) attained from 2000-13 provided for a nearly complete system design, installation of a large portion of the physical infrastructure at the Magdalena Ridge, the first telescope, delay line, fringe tracker and many other necessary sub-systems. New funding has recently been obtained under a cooperative agreement between NM Tech and the Air Force Research Lab (AFRL) to bring the facility to three fully operational telescopes and associated hardware such that first fringes and closure phase will be realized within 5 years. The completed facility will be able to provide support for observing geosynchronous satellites as well as many exciting observations of astronomical targets. An update on the MROI status, plans moving forward for the next 5 years, and some examples of observational applications feasible at different phases of the array's completion will be presented.

Students with No-Contact Orders against Abusive Classmates: Recommendations for Educators

ERIC Educational Resources Information Center

Mayes, Thomas A.

2008-01-01

Teen dating violence is a common and often overlooked problem in schools. The consequences of teen dating violence often include decreased academic achievement and increased risk for school failure. The law may provide relief for targets of teen dating violence, including granting orders of protection (no-contact orders) against their…

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2014 CFR

2014-04-01

... target election for retroactive application—(i) Availability of election. New target may make an... 10, 2006 for which a section 338 election is made, provided that new target's first taxable year and... section 338(h)(10) election is made (or a section 338 election for a foreign target), new target may make...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2012 CFR

2012-04-01

... target election for retroactive application—(i) Availability of election. New target may make an... 10, 2006 for which a section 338 election is made, provided that new target's first taxable year and... section 338(h)(10) election is made (or a section 338 election for a foreign target), new target may make...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2013 CFR

2013-04-01

... target election for retroactive application—(i) Availability of election. New target may make an... 10, 2006 for which a section 338 election is made, provided that new target's first taxable year and... section 338(h)(10) election is made (or a section 338 election for a foreign target), new target may make...

Jealousy during Dating among Female College Students

ERIC Educational Resources Information Center

Khanchandani, Laveena; Durham, Thomas W.

2009-01-01

This study examined the relationship between several situational and personality variables and jealousy in dating relationships among 100 college women volunteers who completed a series of questionnaires about themselves and their dating situations. Six research questions were examined. Results showed that jealousy was lower for women in a steady…

48 CFR 22.805 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... National Preaward Registry via the Internet at http://www.dol-esa.gov/preaward/; (ii) The projected award date is within 24 months of the proposed contractor's Notice of Compliance completion date in the... the OFCCP regional office at least 30 days before the proposed award date. (7) Within 15 days of the...

76 FR 11553 - New York Disaster #NY-00102

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

.../18/2011. Incident: Severe Winter Storm and Snowstorm. Incident Period: 12/26/2010 through 12/27/2010. Effective Date: 02/18/2011. Physical Loan Application Deadline Date: 04/19/2011. Economic Injury (EIDL) Loan Application Deadline Date: 11/18/2011. ADDRESSES: Submit completed loan applications to: U.S. Small Business...

The Effects of the Moms and Teens for Safe Dates Program on Dating Abuse: a Conditional Process Analysis.

PubMed

Foshee, Vangie A; Benefield, Thad; Chen, May S; Reyes, Luz McNaughton; Dixon, Kimberly S; Ennett, Susan T; Moracco, Kathryn E; Bowling, J Michael

2016-04-01

Moms and Teens for Safe Dates (MTSD) is a dating abuse (DA) prevention program for teens exposed to domestic violence. In a randomized controlled trial (RCT), MTSD prevented certain types of DA victimization (psychological and physical) and perpetration (psychological and cyber) among teens with higher, but not lower, exposure to domestic violence. We built on these findings by using moderated mediation analysis to examine whether level of teen exposure to domestic violence conditioned the indirect effects of MTSD on these types of DA through targeted mediators. MTSD consisted of six mailed activity booklets. Mothers who had been former victims of domestic violence delivered the program to their teens. Mother and teen pairs were recruited into the RCT through community advertising and completed baseline and 6-month follow-up interviews (N = 277 pairs). As expected, MTSD had significant favorable effects for teens with higher but not lower exposure to domestic violence on several mediators that guided program content, including teen conflict management skills and mother-perceived severity of DA, self-efficacy for enacting DA prevention efforts, and comfort in communicating with her teen. MTSD had significant main effects on other mediators including teen feeling of family closeness and cohesion and mother-perceived susceptibility of her teen to DA. As expected, all significant indirect effects of MTSD on DA outcomes through mediators were for teens with higher exposure to domestic violence. Findings have implications for developing DA victimization and perpetration prevention programs for teens with high exposure to domestic violence.

78 FR 73580 - Illinois Disaster #IL-00043

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

.... Physical Loan Application Deadline Date: 01/27/2014. Economic Injury (EIDL) Loan Application Deadline Date: 08/26/2014. ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration...

The Influence of Dating Anxiety on Normative Experiences of Dating, Sexual Interactions, and Alcohol Consumption among Canadian Middle Adolescents

ERIC Educational Resources Information Center

Boyle, Andrea M.; O'Sullivan, Lucia F.

2013-01-01

Adolescents tend to consume alcohol and find romantic and sexual partners in mixed-group settings that are unmonitored by adults. Relatively little is known about the influence that dating anxiety may have with these social interactions. A sample of 163 high school students (aged 14-17 years) completed online surveys assessing dating, sex, and…

15 CFR 971.210 - Determination whether application is complete for further processing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... COMMERCIAL RECOVERY PERMITS Applications Procedures § 971.210 Determination whether application is complete... it complete, why the additional information is necessary, and a reasonable date by which the...

Evaluation of a Pharmacist and Nurse Practitioner Smoking Cessation Program.

PubMed

Afzal, Zubair; Pogge, Elizabeth; Boomershine, Virginia

2017-08-01

To evaluate the efficacy of a smoking cessation program led by a pharmacist and a nurse practitioner. During a 6-month period, patients attended 7 one-on-one face-to-face smoking cessation counseling sessions with a pharmacist and 1 to 2 one-on-one face-to-face smoking cessation counseling sessions with a nurse practitioner. The primary outcome was smoking cessation point prevalence rates at months 1, 3, and 5 post-quit date. Secondary outcomes included medication adherence rates at months 1, 3, and 5 post-quit date, nicotine dependence at baseline versus program end, and patient satisfaction. Nine (47%) of 19 total participants completed the program. Seven of the 9 patients who completed the program were smoke-free upon study completion. Point prevalence rates at months 1, 3, and 5 post-quit date were 66%, 77%, and 77%, respectively, based on patients who completed the program. Medication adherence rates were 88.6%, 54.6%, and 75% at months 1, 3, and 5 post-quit date, respectively. Based on the Fagerstrom test, nicotine dependence decreased from baseline to the end of the study, 4.89 to 0.33 ( P < .001). Overall, participants rated the program highly. A joint pharmacist and nurse practitioner smoking cessation program can assist patients in becoming smoke-free.

23 CFR 230.415 - Consolidated compliance reviews.

Code of Federal Regulations, 2011 CFR

2011-04-01

... target area. In identifying the target area of a consolidated compliance review (e.g. SMSA, hometown or...) Present or potential problem areas; (iv) The number of highway projects in the target area; and (v... review period. After the target area has been selected, the dates for the actual onsite reviews shall be...

Rapid-Response Characterization of Near-Earth Asteroids Using KMTNet-SAAO

NASA Astrophysics Data System (ADS)

Erasmus, Nicolas; Mommert, Michael; Trilling, David E.; Sickafoose, Amanda A.; van Gend, Carel; Hora, Joseph L.; Worters, Hannah L.

2017-10-01

We present here VRI spectrophotometry of 39 near-Earth asteroids (NEAs) observed with the Sutherland, South Africa, node of the Korea Microlensing Telescope Network (KMTNet). Of the 39 NEAs, 19 were targeted, but because of KMTNet’s large 2 deg × 2 deg field of view, 20 serendipitous NEAs were also captured in the observing fields. Our rapid-response approach meant targeted observations were performed within 44 days (median: 16 days, min: 4 days) of each NEA’s discovery date. Our broadband spectrophotometry is reliable enough to distinguish among four asteroid taxonomies and we were able to confidently categorize 31 of the 39 observed targets as either a S-, C-, X- or D-type asteroid. Our data suggest that the ratio between “stony” S-type NEAs and “not- stony” (C+X+D)-type NEAs, with H magnitudes between 15 and 25, is roughly 1:1. Additionally, we report ~1-hour light curve data for each NEA. Of the 39 targets, we were able to resolve the complete rotation period and amplitude for six and place lower limits for the remaining targets.Based on the success of this pilot study we plan to continue KMTNet observations but also make use of Lesedi, a new 1-meter remotely-operable telescope also situated in Sutherland, to perform similar spectrophotometric observations in the future. As before, we plan to target newly discovered NEAs in order to continue the rapid-response approach. With Lesedi, observations will take place throughout the year and we plan to include smaller NEAs (larger H magnitudes) in our sample. We will also increase the observed duration of each NEA to 2-3 hours so we are more likely to observe a complete rotation period for our observed NEAs.This study was facilitated by observations made at the South African Astronomical Observatory (SAAO) and this work is partially supported by the South African National Research Foundation (NRF). This work is supported in part by the National Aeronautics and Space Administration (NASA) under grant number NNX15AE90G issued through the SSO Near Earth Object Observations Program and in part by a grant from NASA’s Office of the Chief Technologist.

24 CFR 954.507 - Submission of project completion reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... request for the project. If a satisfactory Project Completion Report is not submitted by the due date, HUD... approvals will remain suspended until a satisfactory Project Completion Report is received. (Approved by the...

Dating Violence and Substance Use as Longitudinal Predictors of Adolescents’ Risky Sexual Behavior

PubMed Central

Shorey, Ryan C.; Fite, Paula J.; Choi, HyeJeong; Cohen, Joseph R.; Stuart, Gregory L.; Temple, Jeff R.

2015-01-01

Objective To examine dating violence perpetration and victimization (physical, psychological, and sexual) and lifetime substance use (alcohol, marijuana, and hard drugs) as longitudinal predictors of adolescents’ risky sexual behavior across one year, and to determine whether predictors varied across adolescents’ gender and ethnicity. Methods A sample of Caucasian, African American, and Hispanic male and female adolescents from 7 public high schools in Texas (N = 882) participated. Adolescents completed self-report measures of dating violence, lifetime substance use, and risky sexual behavior at baseline and, 1-year later, completed a second assessment of their risky sexual behavior. Results Path analysis demonstrated that greater physical dating violence victimization, lifetime alcohol use, lifetime marijuana use, and age (being older) were all significant predictors of risky sexual behavior at the 1-year follow-up. These results did not vary across gender or the three ethnic groups (Caucasian, African American, and Hispanic). Conclusions Overall, substance use was a longitudinal predictor of risky sexual behavior across the three ethnic groups, with physical dating violence victimization being the only type of dating violence longitudinally predicting risky sexual behavior. Prevention efforts should consider the roles of physical dating violence and substance use in preventing risky sexual behavior. PMID:25797949

Depression and Self-Rated Health Among Rural Women Who Experienced Adolescent Dating Abuse: A Mixed Methods Study.

PubMed

Burton, Candace W; Halpern-Felsher, Bonnie; Rehm, Roberta S; Rankin, Sally H; Humphreys, Janice C

2016-03-01

This study used mixed methods to examine the experiences and health of rural, young adult women (N = 100) who self-reported past experience of physical, emotional and verbal, sexual, and relational abuse in adolescent dating relationships. Few studies have examined the lasting health ramifications of adolescent dating abuse adolescent dating abuse in rural populations, and almost no mixed methods studies have explored adolescent dating abuse. Participants completed questionnaires on demographics, relationship behaviors, and mental health symptoms. A subsample (n = 10) of participants also completed semi-structured, in-depth interviews with the primary investigator. Results suggest that depressive symptoms and self-rating of health in these women are associated with particular kinds and severity of abusive experiences, and that adolescent dating abuse has ramifications for health and development beyond the duration of the original relationship. Self-rated health (SRH) was inversely associated with abusive behaviors in the relationship, whereas depressive symptoms were positively correlated with such behaviors. Self-rated health was also negatively correlated with depressive symptoms. The results of this study represent an important step toward establishing lifetime health risks posed by adolescent dating abuse. © The Author(s) 2014.

Dating Violence and Substance Use as Longitudinal Predictors of Adolescents' Risky Sexual Behavior.

PubMed

Shorey, Ryan C; Fite, Paula J; Choi, HyeJeong; Cohen, Joseph R; Stuart, Gregory L; Temple, Jeff R

2015-08-01

The objectives of this study is to examine dating violence perpetration and victimization (physical, psychological, and sexual) and lifetime substance use (alcohol, marijuana, and hard drugs) as longitudinal predictors of adolescents' risky sexual behavior across 1 year and to determine whether predictors varied across adolescents' gender and ethnicity. A sample of Caucasian, African American, and Hispanic male and female adolescents from seven public high schools in Texas (N = 882) participated. Adolescents completed self-report measures of dating violence, lifetime substance use, and risky sexual behavior at baseline and, 1-year later, completed a second assessment of their risky sexual behavior. Path analysis demonstrated that greater physical dating violence victimization, lifetime alcohol use, lifetime marijuana use, and age (being older) were all significant predictors of risky sexual behavior at the 1-year follow-up. These results did not vary across gender or the three ethnic groups (Caucasian, African American, and Hispanic). Overall, substance use was a longitudinal predictor of risky sexual behavior across the three ethnic groups, with physical dating violence victimization being the only type of dating violence longitudinally predicting risky sexual behavior. Prevention efforts should consider the roles of physical dating violence and substance use in preventing risky sexual behavior.

Dating Violence and Self-Injury among Undergraduate College Students: Attitudes and Experiences

ERIC Educational Resources Information Center

Murray, Christine E.; Wester, Kelly L.; Paladino, Derrick A.

2008-01-01

An Internet-based survey about dating violence and self-injury was completed by 1,777 undergraduates. A regression analysis tested if recent dating violence victimization and perpetration experiences predicted whether participants self-injured in the past 90 days, after controlling for demographic variables and attitudes toward self-injury and…

San Bernardino Valley College Strategic Enrollment Management Plan: Recruitment and Retention, 2000-2002.

ERIC Educational Resources Information Center

Romero, David T., Ed.

The San Bernardino Valley College (California) Strategic Enrollment Management (SEM) Plan was developed to specifically increase student enrollment and to improve retention over 2000-2002, and thereafter. Presents the SEM plan in two parts: recruitment and retention. The date, description, action, person responsible, date needed, date completed,…

33 CFR 156.150 - Declaration of inspection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... operation if not at a facility; (3) The date and time the transfer operation is started; (4) A list of the... transfer operations on the transferring vessel or facility and a space for the date, time of signing... transferring product; and (6) The date and time the transfer operation is completed. (d) The form for the...

33 CFR 156.150 - Declaration of inspection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... operation if not at a facility; (3) The date and time the transfer operation is started; (4) A list of the... transfer operations on the transferring vessel or facility and a space for the date, time of signing... transferring product; and (6) The date and time the transfer operation is completed. (d) The form for the...

33 CFR 156.150 - Declaration of inspection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... operation if not at a facility; (3) The date and time the transfer operation is started; (4) A list of the... transfer operations on the transferring vessel or facility and a space for the date, time of signing... transferring product; and (6) The date and time the transfer operation is completed. (d) The form for the...

33 CFR 156.150 - Declaration of inspection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... operation if not at a facility; (3) The date and time the transfer operation is started; (4) A list of the... transfer operations on the transferring vessel or facility and a space for the date, time of signing... transferring product; and (6) The date and time the transfer operation is completed. (d) The form for the...

33 CFR 156.150 - Declaration of inspection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... operation if not at a facility; (3) The date and time the transfer operation is started; (4) A list of the... transfer operations on the transferring vessel or facility and a space for the date, time of signing... transferring product; and (6) The date and time the transfer operation is completed. (d) The form for the...

SIM PlanetQuest Key Project Precursor Observations to Detect Gas Giant Planets Around Young Stars

NASA Technical Reports Server (NTRS)

Tanner, Angelle; Beichman, Charles; Akeson, Rachel; Ghez, Andrea; Grankin, Konstantin N.; Herbst, William; Hillenbrand, Lynne; Huerta, Marcos; Konopacky, Quinn; Metchev, Stanimir;

Detecting cold, wide orbit planets in the solar neighbourhood

NASA Astrophysics Data System (ADS)

Deacon, Niall; Kraus, Adam

2018-05-01

Direct imaging exoplanet studies have recently unveiled a previously unexpected population of massive planets in wide orbits (>100AU). Although most of these discoveries have been around younger stars and have been of similar temperatures to field brown dwarfs, one object (WD 0806-661B), is the coldest planet known outside our solar system. In Spitzer Cycle 11 we surveyed stars and brown dwarfs within 8pc to identify massive planetary companions in the 150-1500AU separation range. Only 56 of our 196 stars were observed with two epochs of observation. We propose second epoch observations for 80 targets with first, but little or no second epoch observations. We will 1) Measure the fraction of wide planetary mass companions to stars in the Solar neighbourhood. 2) Identify approximately 5 planets, three of which will have temperatures below 300K making them ideal targets to study water clouds in cold atmospheres with both JWST and the next generation of ground-based extremely large telescopes. 3) Identify all planets around our target stars with masses above 8 Jupiter masses in our chosen projected separation range with lower mass limits for closer and younger stars. Our survey will be the most complete survey for wide planets to-date and will provide both a measurement of the wide planet population and a legacy of cold, well-constrained targets for future observations with JWST and Extremely Large Telescopes.

Pathway Profiling and Rational Trial Design for Studies in Advanced Stage Cervical Carcinoma: A Review and a Perspective

PubMed Central

Scholl, Susy M. E.; Kenter, Gemma; Kurzeder, Christian; Beuzeboc, Philippe

2011-01-01

Multiple genetic abnormalities will have occurred in advanced cervical cancer and multiple targeting is likely to be needed to control tumor growth. To date, dominant therapeutic targets under scrutiny for cervical cancer treatment have been EGFR pathway and angiogenesis inhibition as well as anti-HPV vaccines. The potentially most effective targets to be blocked may be downstream from the membrane receptor or at the level of the nucleus. Alterations of the pathways involved in DNA repair and in checkpoint activations, as well as the specific site of HPV genome integration, appear worth assessing. For genetic mutational analysis, complete exon sequencing may become the norm in the future but at this stage frequent mutations (that matter) can be verified by PCR analysis. A precise documentation of relevant alterations of a large spectrum of protein biomarkers can be carried out by reverse phase protein array (RPPA) or by multiplex analysis. Clinical decision-making on the drug(s) of choice as a function of the biological alteration will need input from bio-informatics platforms as well as novel statistical designs. Endpoints are yet to be defined such as the loss (or reappearance) of a predictive biomarker. Single or dual targeting needs to be explored first in relevant preclinical animal and in xenograft models prior to clinical deployment. PMID:22091418

I'm hot, so i'd say you're not: the influence of objective physical attractiveness on mate selection.

PubMed

Montoya, R Matthew

2008-10-01

Four studies investigated the importance of objective and subjective attributes to mate selection. This research tested whether perceivers' objective physical attractiveness influenced how they evaluated the physical attractiveness of others and, if considered, may provide a parsimonious account for matching in mate selection. Study 1 (N = 102) demonstrated that ratings of targets' attractiveness decreased as perceivers' objective physical attractiveness increased. Studies 2 (N = 89) and 3 (N = 68) revealed that as perceivers' objective physical attractiveness increased, reductions in expected satisfaction and rejection were mediated by perceivers' reduced assessments of targets' attractiveness. Study 4 (N = 114) produced patterns of matching by finding that attractive perceivers expected to date more attractive targets while unattractive perceivers expected to date less attractive targets. This research emphasizes the importance of objective physical attractiveness to target evaluations and describes how matching results from the combined influence of objective and subjective attributes.

77 FR 2081 - Notice of Inventory Completion: Minnesota Indian Affairs Council, Bemidji, MN

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

... requestors come forward. DATES: Representatives of any Indian tribe that believes it has a cultural... Minnesota Chippewa Tribe, Minnesota may proceed after that date if no additional requestors come forward...

Listing of awardee names: Active awards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-07-01

This catalog/directory presents DOE`s procurement and assistance data system, arranged according to awardee name, bin, completion date, description of work, division, vendor ID, city, state, congressional district, contract value, obligations to date, P/S.

VizieR Online Data Catalog: C IV BAL troughs properties in quasars (Filiz+, 2014)

NASA Astrophysics Data System (ADS)

Filiz, Ak N.; Brandt, W. N.; Hall, P. B.; Schneider, D. P.; Trump, J. R.; Anderson, S. F.; Hamann, F.; Myers, A. D.; Paris, I.; Petitjean, P.; Ross, N. P.; Shen, Y.; York, D.

2017-03-01

We utilize spectroscopic observations from the Sloan Digital Sky Survey-I/II (hereafter SDSS, York et al. 2000AJ....120.1579Y) and the Baryon Oscillation Spectroscopic Survey of SDSS-III (hereafter BOSS; Eisenstein et al. 2011AJ....142...72E; Dawson et al. 2013AJ....145...10D). We select a sample of quasars for this study from these 2005 targets that were observed by SDSS between MJD 51,602 (2000 February 28) and 54,557 (2008 January 4) and by BOSS between MJD 55,176 (2009 December 11) and 56,455 (2013 June 12). Observation start dates correspond to completion of hardware commissioning for both SDSS and BOSS; post-commissioning observations have the most reliable spectral calibration. (7 data files).

Dating Violence and Girls in the Juvenile Justice System

ERIC Educational Resources Information Center

Kelly, Patricia J.; Cheng, An-Lin; Peralez-Dieckmann, Esther; Martinez, Elisabeth

2009-01-01

The purpose of this study is to explore the prevalence and associated behaviors of dating violence among a population of girls in the juvenile justice system. A sample of 590 girls from an urban juvenile justice system completed a questionnaire assessing attitudes and self-efficacy about and occurrence of dating violence. The analysis developed a…

The Dating Anxiety Scale for Adolescents: Scale Development and Associations with Adolescent Functioning

ERIC Educational Resources Information Center

Glickman, Alissa R.; La Greca, Annette M.

2004-01-01

Given the importance of romantic and dating relationships during adolescence, the purpose of the study was to develop and evaluate the psychometric properties of the Dating Anxiety Scale for Adolescents (DAS-A). Participants were 757 high school students (56% girls, ages 15 to 18 years). Adolescents completed the DAS-A, the Social Anxiety Scale…

Adolescent Dating Experiences Described by Latino College Students

ERIC Educational Resources Information Center

Raffaelli, M.

2005-01-01

Latino college students (M age=21.4 years) completed self-report surveys assessing adolescent dating experiences. Compared to young men (n=69), young women (n=97) had more limitations placed on them by parents as adolescents and began dating later. No gender difference in timing of the first serious relationship emerged. More young women had their…

21 CFR 60.22 - Regulatory review period determinations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... drugs: (1) The testing phase begins on the date an exemption under section 505(i) of the Act becomes... Act and ends on the date the protocol is declared to be completed. (d) For animal drugs: (1) The... animal drug, whichever is earlier, and ends on the date a marketing application under section 512 of the...

21 CFR 60.22 - Regulatory review period determinations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... drugs: (1) The testing phase begins on the date an exemption under section 505(i) of the Act becomes... Act and ends on the date the protocol is declared to be completed. (d) For animal drugs: (1) The... animal drug, whichever is earlier, and ends on the date a marketing application under section 512 of the...

21 CFR 60.22 - Regulatory review period determinations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... drugs: (1) The testing phase begins on the date an exemption under section 505(i) of the Act becomes... Act and ends on the date the protocol is declared to be completed. (d) For animal drugs: (1) The... animal drug, whichever is earlier, and ends on the date a marketing application under section 512 of the...

21 CFR 60.22 - Regulatory review period determinations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... drugs: (1) The testing phase begins on the date an exemption under section 505(i) of the Act becomes... Act and ends on the date the protocol is declared to be completed. (d) For animal drugs: (1) The... animal drug, whichever is earlier, and ends on the date a marketing application under section 512 of the...

21 CFR 60.22 - Regulatory review period determinations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... drugs: (1) The testing phase begins on the date an exemption under section 505(i) of the Act becomes... Act and ends on the date the protocol is declared to be completed. (d) For animal drugs: (1) The... animal drug, whichever is earlier, and ends on the date a marketing application under section 512 of the...

Patients with schizophrenia activate behavioural intentions facilitated by counterfactual reasoning

PubMed Central

Tebé, Cristian; Benejam, Bessy; Caño, Agnes; Menchón, José Manuel

2017-01-01

Previous research has associated schizophrenia with an inability to activate behavioural intentions facilitated by counterfactual thinking (CFT) as a step to improving performance. Consequently, these findings suggest that rehabilitation strategies will be entirely ineffective. To extend previous research, we evaluated the influence of CFT in the activation of behavioural intentions using a novel sequential priming paradigm in the largest sample of subjects explored to date. Method The main variables assessed were: answer to complete a target task (wrong or correctly), and percentage gain in the reaction time (RT) to complete a target task correctly depending on whether the prime was a counterfactual or a neutral-control cue. These variables were assessed in 37 patients with schizophrenia and 37 healthy controls. Potential associations with clinical status and socio-demographic characteristics were also explored. Results When a counterfactual prime was presented, the probability of giving an incorrect answer was lower for the entire sample than when a neutral prime was presented (OR 0.58; CI 95% 0.42 to 0.79), but the schizophrenia patients showed a higher probability than the controls of giving an incorrect answer (OR 3.89; CI 95% 2.0 to 7.6). Both the schizophrenia patients and the controls showed a similar percentage gain in RT to a correct answer of 8%. Conclusions Challenging the results of previous research, our findings suggest a normal activation of behavioural intentions facilitated by CFT in schizophrenia. Nevertheless, the patients showed more difficulty than the controls with the task, adding support to the concept of CFT as a potential new target for consideration in future therapeutic approaches for this illness. PMID:28586400

Identification and qualification of 500 nuclear, single-copy, orthologous genes for the Eupulmonata (Gastropoda) using transcriptome sequencing and exon capture.

PubMed

Teasdale, Luisa C; Köhler, Frank; Murray, Kevin D; O'Hara, Tim; Moussalli, Adnan

2016-09-01

The qualification of orthology is a significant challenge when developing large, multiloci phylogenetic data sets from assembled transcripts. Transcriptome assemblies have various attributes, such as fragmentation, frameshifts and mis-indexing, which pose problems to automated methods of orthology assessment. Here, we identify a set of orthologous single-copy genes from transcriptome assemblies for the land snails and slugs (Eupulmonata) using a thorough approach to orthology determination involving manual alignment curation, gene tree assessment and sequencing from genomic DNA. We qualified the orthology of 500 nuclear, protein-coding genes from the transcriptome assemblies of 21 eupulmonate species to produce the most complete phylogenetic data matrix for a major molluscan lineage to date, both in terms of taxon and character completeness. Exon capture targeting 490 of the 500 genes (those with at least one exon >120 bp) from 22 species of Australian Camaenidae successfully captured sequences of 2825 exons (representing all targeted genes), with only a 3.7% reduction in the data matrix due to the presence of putative paralogs or pseudogenes. The automated pipeline Agalma retrieved the majority of the manually qualified 500 single-copy gene set and identified a further 375 putative single-copy genes, although it failed to account for fragmented transcripts resulting in lower data matrix completeness when considering the original 500 genes. This could potentially explain the minor inconsistencies we observed in the supported topologies for the 21 eupulmonate species between the manually curated and 'Agalma-equivalent' data set (sharing 458 genes). Overall, our study confirms the utility of the 500 gene set to resolve phylogenetic relationships at a range of evolutionary depths and highlights the importance of addressing fragmentation at the homolog alignment stage for probe design. © 2016 John Wiley & Sons Ltd.

Glucocorticoid Receptor Interacting Co-regulators: Putative Candidates for Future Drug Targeting Therapy.

PubMed

Di Silvestre, Alessia; Lucafo, Marianna; De Iudicibus, Sara; Ventura, Alessandro; Martelossi, Stefano; Stocco, Gabriele; Decorti, Giuliana

2017-01-01

Glucocorticoids (GCs) are largely used in different inflammatory, autoimmune and proliferative diseases. To date their mechanism of action is not completely clear and more studies are necessary, in particular to explain the great interindividual variability in clinical response. In this panorama the glucocorticoid receptor (GR) has an important role: in fact it regulates the pharmacological response thanks to the capability to interact with different molecules (DNA, RNA, ncRNA and proteins) that are known to influence its activity. In this review our aim is to highlight the knowledge about the role of protein-protein, RNAprotein interactions and epigenetic modifications on the GR and the consequent response to GCs. The characteristics of these interactions with the GR and their effects on the pharmacological activity of GCs will be examined. This information could contribute to the prediction of individual sensitivity to steroids through the identification of new markers of GC resistance. In addition this knowledge may be used in developing new strategies for targeted therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Apatinib in gastric carcinoma: A case report of partial response for first-line treatment in advanced disease.

PubMed

Wang, Yaping; Bi, Minghong; Zhang, Haoran; Gao, Zhenyuan; Zhou, Hairong; Chang, Shu

2017-10-01

Gastric cancer (GC) is the most common gastrointestinal malignant tumor, with a gradual increasing incidence throughout the world. Mostly GC is diagnosed in its late stage. To date, there is no usable standardized treatment regimen for patients with advanced GC. Apatinib mesylate, small-molecule vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor (TKI), has been approved as third-line treatment for patients with advanced gastric adenocarcinoma in China, October, 2014. Till now, there is no case report about apatinib as first-line treatment for patients with advanced GC in literature. We present an 83-year-old Chinese man with advanced gastric adenocarcinoma, who received apatinib as first-line option and obtained clinical benefit within 2 weeks. The lung metastases disappeared completely and the liver metastases shrank significantly. The patient's progression-free survival was 163 days and overall survival was 201 days. This paper reviews and discusses apatinib as a new targeted drug for patients with advanced GC by comparison with other effective molecular-targeted therapy. © 2016 John Wiley & Sons Australia, Ltd.

Mitochondrial genomes reveal the extinct Hippidion as an outgroup to all living equids.

PubMed

Der Sarkissian, Clio; Vilstrup, Julia T; Schubert, Mikkel; Seguin-Orlando, Andaine; Eme, David; Weinstock, Jacobo; Alberdi, Maria Teresa; Martin, Fabiana; Lopez, Patricio M; Prado, Jose L; Prieto, Alfredo; Douady, Christophe J; Stafford, Tom W; Willerslev, Eske; Orlando, Ludovic

2015-03-01

Hippidions were equids with very distinctive anatomical features. They lived in South America 2.5 million years ago (Ma) until their extinction approximately 10 000 years ago. The evolutionary origin of the three known Hippidion morphospecies is still disputed. Based on palaeontological data, Hippidion could have diverged from the lineage leading to modern equids before 10 Ma. In contrast, a much later divergence date, with Hippidion nesting within modern equids, was indicated by partial ancient mitochondrial DNA sequences. Here, we characterized eight Hippidion complete mitochondrial genomes at 3.4-386.3-fold coverage using target-enrichment capture and next-generation sequencing. Our dataset reveals that the two morphospecies sequenced (H. saldiasi and H. principale) formed a monophyletic clade, basal to extant and extinct Equus lineages. This contrasts with previous genetic analyses and supports Hippidion as a distinct genus, in agreement with palaeontological models. We date the Hippidion split from Equus at 5.6-6.5 Ma, suggesting an early divergence in North America prior to the colonization of South America, after the formation of the Panamanian Isthmus 3.5 Ma and the Great American Biotic Interchange. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Mitochondrial genomes reveal the extinct Hippidion as an outgroup to all living equids

PubMed Central

Der Sarkissian, Clio; Vilstrup, Julia T.; Schubert, Mikkel; Seguin-Orlando, Andaine; Eme, David; Weinstock, Jacobo; Alberdi, Maria Teresa; Martin, Fabiana; Lopez, Patricio M.; Prado, Jose L.; Prieto, Alfredo; Douady, Christophe J.; Stafford, Tom W.; Willerslev, Eske; Orlando, Ludovic

2015-01-01

Hippidions were equids with very distinctive anatomical features. They lived in South America 2.5 million years ago (Ma) until their extinction approximately 10 000 years ago. The evolutionary origin of the three known Hippidion morphospecies is still disputed. Based on palaeontological data, Hippidion could have diverged from the lineage leading to modern equids before 10 Ma. In contrast, a much later divergence date, with Hippidion nesting within modern equids, was indicated by partial ancient mitochondrial DNA sequences. Here, we characterized eight Hippidion complete mitochondrial genomes at 3.4–386.3-fold coverage using target-enrichment capture and next-generation sequencing. Our dataset reveals that the two morphospecies sequenced (H. saldiasi and H. principale) formed a monophyletic clade, basal to extant and extinct Equus lineages. This contrasts with previous genetic analyses and supports Hippidion as a distinct genus, in agreement with palaeontological models. We date the Hippidion split from Equus at 5.6–6.5 Ma, suggesting an early divergence in North America prior to the colonization of South America, after the formation of the Panamanian Isthmus 3.5 Ma and the Great American Biotic Interchange. PMID:25762573

Channeling Nanoparticles for Detection and Targeted Treatment of Breast Cancerous Lesions

DTIC Science & Technology

2011-10-01

µmoles, or 16.5mg) of PEG 2000. Dimethylaminopyridine (DMAP, 0.5 molar equivalents) and 1 -Ethyl- 3 - [ 3 - dimethylaminopropyl ]carbodiimide (EDC...control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1 . REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3 . DATES COVERED (From - To) 4. TITLE...OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1 . REPORT DATE (DD-MM-YYYY) 14-10-2011 2. REPORT TYPE Final 3 . DATES

Monitoring and evaluating surgical care: defining perioperative mortality rate and standardising data collection.

PubMed

Palmqvist, Charlotta L; Ariyaratnam, Roshan; Watters, David A; Laing, Grant L; Stupart, Douglas; Hider, Phil; Ng-Kamstra, Joshua S; Wilson, Leona; Clarke, Damian L; Hagander, Lars; Greenberg, Sarah L M; Gruen, Russell L

2015-04-27

Case volume per 100 000 population and perioperative mortality rate (POMR) are key indicators to monitor and strengthen surgical services. However, comparisons of POMR have been restricted by absence of standardised approaches to when it is measured, the ideal denominator, need for risk adjustment, and whether data are available. We aimed to address these issues and recommend a minimum dataset by analysing four large mixed surgical datasets, two from well-resourced settings with sophisticated electronic patient information systems and two from resource-limited settings where clinicians maintain locally developed databases. We obtained data from the New Zealand (NZ) National Minimum Dataset, the Geelong Hospital patient management system in Australia, and purpose-built surgical databases in Pietermaritzburg, South Africa (PMZ) and Port Moresby, Papua New Guinea (PNG). Information was sought on inclusion and exclusion criteria, coding criteria, and completeness of patient identifiers, admission, procedure, discharge and death dates, operation details, urgency of admission, and American Society of Anesthesiologists (ASA) score. Date-related errors were defined as missing dates and impossible discrepancies. For every site, we then calculated the POMR, the effect of admission episodes or procedures as denominator, and the difference between in-hospital POMR and 30-day POMR. To determine the need for risk adjustment, we used univariate and multivariate logistic regression to assess the effect on relative POMR for each site of age, admission urgency, ASA score, and procedure type. 1 365 773 patient admissions involving 1 514 242 procedures were included, among which 8655 deaths were recorded within 30 days. Database inclusion and exclusion criteria differed substantially. NZ and Geelong records had less than 0·1% date-related errors and greater than 99·9% completeness. PMZ databases had 99·9% or greater completeness of all data except date-related items (94·0%). PNG had 99·9% or greater completeness for date of birth or age and admission date and operative procedure, but 80-83% completeness of patient identifiers and date related items. Coding of procedures was not standardised, and only NZ recorded ASA status and complete post-discharge mortality. In-hospital POMR range was 0·38% in NZ to 3·44% in PMZ, and in NZ it underestimated 30-day POMR by roughly a third. The difference in POMR by procedures instead of admission episodes as denominator ranged from 10% to 70%. Age older than 65 years and emergency admission had large independent effects on POMR, but relatively little effect in multivariate analysis on the relative odds of in-hospital death at each site. Hospitals can collect and provide data for case volume and POMR without sophisticated electronic information systems. POMR should initially be defined by in-hospital mortality because post-discharge deaths are not usually recorded, and with procedures as denominator because details allowing linkage of several operations within one patient's admission are not always present. Although age and admission urgency are independently associated with POMR, and ASA and case mix were not included, risk adjustment might not be essential because the relative odds between sites persisted. Standardisation of inclusion criteria and definitions is needed, as is attention to accuracy and completeness of dates of procedures, discharge and death. A one-page, paper-based form, or alternatively a simple electronic data collection form, containing a minimum dataset commenced in the operating theatre could facilitate this process. None. Copyright © 2015 Elsevier Ltd. All rights reserved.

Publication status of contemporary oncology randomised controlled trials worldwide.

PubMed

Chen, Yu-Pei; Liu, Xu; Lv, Jia-Wei; Li, Wen-Fei; Zhang, Yuan; Guo, Ying; Lin, Ai-Hua; Sun, Ying; Mao, Yan-Ping; Ma, Jun

2016-10-01

Little is known about the extent of selective publication in contemporary oncology randomised controlled trials (RCTs) worldwide. This study aimed to evaluate the rates of publication and timely publication (within 24 months) for contemporary oncology RCTs from all over the world. We also investigated the trial characteristics associated with publication and timely publication. We identified all phase III oncology RCTs registered on ClinicalTrials.gov with a primary completion date between January 2008 and December 2012. We searched PubMed and EMBASE to identify publications. The final search date was 31 December 2015. Our primary outcome measure was the time to publication from the primary completion date to the date of primary publication in a peer-reviewed journal. We identified 598 completed oncology RCTs; overall, 398 (66.6%) had been published. For published trials, the median time to publication was 25 months (interquartile range, 16-37 months). Only 192 trials (32.1%) were published within 24 months. Timely publication was independently associated with trials completed late in 2012. Trials conducted in Asia and other regions were less likely to have timely publication, but trials conducted in different locations were all equally likely to be published. Industry- and NIH-funded trials were equally likely to be published timely or at any time after trial completion. Among 391 published trials with clear primary outcomes, there was a trend for timely publication of positive trials compared with negative trials. Despite the ethical obligations and societal expectations of disclosing findings promptly, oncology RCTs performed poorly. Copyright © 2016 Elsevier Ltd. All rights reserved.

The US National Tuberculosis Surveillance System: A Descriptive Assessment of the Completeness and Consistency of Data Reported from 2008 to 2012.

PubMed

Yelk Woodruff, Rachel S; Pratt, Robert H; Armstrong, Lori R

2015-01-01

In 2009, the Tuberculosis (TB) Information Management System transitioned into the National TB Surveillance System to allow use of 4 different types of electronic reporting schemes: state-built, commercial, and 2 schemes developed by the Centers for Disease Control and Prevention. Simultaneously, the reporting form was revised to include additional data fields. Describe data completeness for the years 2008-2012 and determine the impact of surveillance changes. Data were categorized into subgroups and assessed for completeness (eg, the percentage of patients dead at diagnosis who had a date of death reported) and consistency (eg, the percentage of patients alive at diagnosis who erroneously had a date of death reported). Reporting jurisdictions were grouped to examine differences by reporting scheme. Each year less than 1% of reported cases had missing information for country of origin, race, or ethnicity. Patients reported as dead at diagnosis had death date (a new data field) missing for 3.6% in 2009 and 4.4% in 2012. From 2010 to 2012, 313 cases (1%) reported as alive at diagnosis had a death date and all of these were reported through state-built or commercial systems. The completeness of reporting for guardian country of birth for pediatric patients (a new data field) ranged from 84% in 2009 to 88.2% in 2011. Despite major changes, completeness has remained high for most data elements in TB surveillance. However, some data fields introduced in 2009 remain incomplete; continued training is needed to improve national TB surveillance data.

77 FR 23504 - Notice of Inventory Completion: Illinois State Museum, Springfield, IL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-19

... remains to the Indian tribes stated below may occur if no additional claimants come forward. DATES... Keetoowah Band of Cherokee Indians in Oklahoma may proceed after that date if no additional claimants come...

26 CFR 1.338-6 - Allocation of ADSP and AGUB among target assets.

Code of Federal Regulations, 2010 CFR

2010-04-01

... allocated among Class II acquisition date assets of target in proportion to the fair market values of such... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Allocation of ADSP and AGUB among target assets... among target assets. (a) Scope—(1) In general. This section prescribes rules for allocating ADSP and...

Delivering quality of care while managing the interests of all stakeholders.

PubMed

Stopper, Andrea; Raddatz, Agnieszka; Grassmann, Aileen; Stuard, Stefano; Menzer, Marcus; Possnien, Gernot; Scatizzi, Laura; Marcelli, Daniele

2011-01-01

National healthcare systems worldwide face growing challenges to reconcile interests of patients for high-quality medical care and of payers for sustainable and affordable funding. Advances in the provision of renal replacement therapy can only be made by developing and implementing appropriate sophisticated and state-of-the-art business models that include reimbursement schemes for comprehensive care packages. Such business models must succeed in integrating and reconciling the interests of all stakeholders. NephroCare as dialysis provider has adopted and tailored recognized management techniques, i.e. Balanced Scorecard and Kaizen, to achieve these goals. Success of the complete business model package is tangible - strategies initiated to improve treatment quality even at the cost of providers have been translated into win-win scenarios for the complete stakeholder community. Room for improvement exists: the possibility to extend the portfolio of service offerings within the comprehensive care frame, as well as the challenge for achieving a balance between the stability of targets while keeping these up to date concerning new insights. Copyright © 2011 S. Karger AG, Basel.

Lower Methow tributaries intensive effectiveness monitoring study. Interim report

USGS Publications Warehouse

Martens, Kyle D.; Connolly, Patrick J.

2008-01-01

Actions have been taken to replace diversion dams in lower Beaver Creek with a series of rock vortex weirs. Some of these diversion dams have been in place for over 100 years, and they have impaired or completely blocked upstream migration of fish. Three diversion dams were replaced in 2003 (Lower Stokes, Thurlow Transfer, and Upper Stokes), and a forth diversion dam was replaced in 2004 (Fort-Thurlow). These vortex weirs were designed and installed under the supervision of U.S. Bureau of Reclamation (BOR) engineers and completed in accordance to National Marine Fisheries Service (NMFS) and Washington Department of Fisheries and Wildlife (WDFW) fish passage criteria. The projects were designed to meet fish species recovery needs described by the Endangered Species Act (ESA) and the “BiOp” issued by NMFS (2000a). Since no specific guidelines have been identified to date specifically addressing diversion dams, WDFW and NMFS guidelines are being considered as the target design and performance criteria for the sites monitored as part of this project. Where used, the vortex weirs were designed to maintain irrigation diversion capabilities while improving fish passage.

77 FR 25743 - Notice of Inventory Completion: Fowler Museum at UCLA, Los Angeles, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... no additional claimants come forward. DATES: Representatives of any Indian tribe that believes it has... after that date if no additional claimants come forward. The Fowler Museum at UCLA is responsible for...

32 CFR 37.1370 - Termination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... cancellation of a TIA, in whole or in part, at any time prior to either: (a) The date on which all work under the TIA is completed; or (b) The date on which Federal sponsorship ends, as given in the award...

10 CFR 603.1335 - Termination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Used in this Part § 603.1335 Termination. The cancellation of a TIA, in whole or in part, at any time prior to either: (a) The date on which all work under the TIA is completed; or (b) The date on which...

76 FR 33728 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-09

... measures, types of orders, accomplishments, skills and competencies, career preferences, contract.... Education and training: Graduation dates and locations, highest level of education, other education, training and school information including courses and training completion dates. Pay Entitlement and...

40 CFR 60.1650 - Who must complete the operator training course? By when?

Code of Federal Regulations, 2011 CFR

2011-07-01

... American Society of Mechanical Engineers on or before the effective date of State plan approval. (d) You... certification from the American Society of Mechanical Engineers on or before the effective date of State plan...

40 CFR 60.1650 - Who must complete the operator training course? By when?

Code of Federal Regulations, 2010 CFR

2010-07-01

... American Society of Mechanical Engineers on or before the effective date of State plan approval. (d) You... certification from the American Society of Mechanical Engineers on or before the effective date of State plan...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2010 CFR

2010-04-01

....338-11 apply to qualified stock purchases occurring on or after April 10, 2006. (2) New target election for retroactive application—(i) Availability of election. New target may make an irrevocable..., 2006 for which a section 338 election is made, provided that new target's first taxable year and all...

26 CFR 1.338(i)-1 - Effective/applicability date.

Code of Federal Regulations, 2011 CFR

2011-04-01

....338-11 apply to qualified stock purchases occurring on or after April 10, 2006. (2) New target election for retroactive application—(i) Availability of election. New target may make an irrevocable..., 2006 for which a section 338 election is made, provided that new target's first taxable year and all...

75 FR 18545 - MMS Information Collection Activity: 1010-0067, Oil and Gas Well-Completion Operations, Extension...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... Information Collection Activity: 1010-0067, Oil and Gas Well- Completion Operations, Extension of a Collection... requirements in the regulations under 30 CFR 250, Subpart E, ``Oil and Gas Well-Completion Operations.'' DATES... address. SUPPLEMENTARY INFORMATION: Title: 30 CFR part 250, subpart E, Oil and Gas Well-Completion...

Safety Testing of Lithium (Sulfur Dioxide) Battery for Expendable, Mobile, ASW Training Target (EMATT)

DTIC Science & Technology

1988-12-01

Projict (0704.0115), YlissiengtOn, DC ;(1503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE 3. REOTTYPE AN) DATES COVERED 4. TITLE AND SUBTITLE 1...EXPENDABLE, MOBILE, ASW TRAINING TARGET (EMATT) 1-1 NSWC TR 88-254 The EMATT unit was first designed to use a lithium/sulfuryl chloride (Li/SO2 CI 2 ) "DD...in Table 3-1. Short Circuit Test The battery was shorted by the use of a remotely controlled relay. The relay, rated at 100 amp 250V, was employed

KSC-08pd3253

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lowers the Flight Support System carrier onto a stand in the PHSF. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

KSC-08pd3257

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lowers the Multi-Use Lightweight Equipment, or MULE, carrier toward a stand. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

KSC-08pd3258

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lowers the Multi-Use Lightweight Equipment, or MULE, carrier toward a stand. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

KSC-08pd3256

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane moves the Multi-Use Lightweight Equipment, or MULE, carrier toward a stand. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

KSC-08pd3259

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lowers the Multi-Use Lightweight Equipment, or MULE, carrier onto a stand. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

Co-Targeting HER2 and EphB4 Pathways

DTIC Science & Technology

2013-07-01

progress has been made toward the clinic. An IND has been obtained for sEphbB4- HSA, an albumin stabilized soluble EphB4 decoy receptor that efficiently...for activated HER2/HER family receptors , angiogenic markers (EphrinB2, EphB1,2,3,4,6, VEGF, VEGFR-1, 2, 3 and PDGFR), vessel density, signal...ABOVE ADDRESS. 1. REPORT DATE 2. REPORT TYPE 3 . DATES COVERED 4. TITLE AND SUBTITLE Co-Targeting HER2 and EphB4 Pathways 5a. CONTRACT NUMBER 5b

Structured data quality reports to improve EHR data quality.

PubMed

Taggart, Jane; Liaw, Siaw-Teng; Yu, Hairong

2015-12-01

To examine whether a structured data quality report (SDQR) and feedback sessions with practice principals and managers improve the quality of routinely collected data in EHRs. The intervention was conducted in four general practices participating in the Fairfield neighborhood electronic Practice Based Research Network (ePBRN). Data were extracted from their clinical information systems and summarised as a SDQR to guide feedback to practice principals and managers at 0, 4, 8 and 12 months. Data quality (DQ) metrics included completeness, correctness, consistency and duplication of patient records. Information on data recording practices, data quality improvement, and utility of SDQRs was collected at the feedback sessions at the practices. The main outcome measure was change in the recording of clinical information and level of meeting Royal Australian College of General Practice (RACGP) targets. Birth date was 100% and gender 99% complete at baseline and maintained. DQ of all variables measured improved significantly (p<0.01) over 12 months, but was not sufficient to comply with RACGP standards. Improvement was greatest with allergies. There was no significant change in duplicate records. SDQRs and feedback sessions support general practitioners and practice managers to focus on improving the recording of patient information. However, improved practice DQ, was not sufficient to meet RACGP targets. Randomised controlled studies are required to evaluate strategies to improve data quality and any associated improved safety and quality of care. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors.

PubMed

Mahalingam, Sakkarapalayam M; Dudkin, Vadim Y; Goldberg, Shalom; Klein, Donna; Yi, Fang; Singhal, Sunil; O'Neil, Karyn T; Low, Philip S

2017-11-15

Tumor-targeted near-infrared fluorescent dyes have the potential to improve cancer surgery by enabling surgeons to locate and resect more malignant lesions where good visualization tools are required to ensure complete removal of malignant tissue. Although the tumor-targeted fluorescent dyes used in humans to date have been either small organic molecules or high molecular weight antibodies, low molecular weight protein scaffolds have attracted significant attention because they penetrate solid tumors almost as efficiently as small molecules, but can be infinitely mutated to bind almost any antigen. Here we describe the use of a 10 kDa protein scaffold, a Centyrin, to target a near-infrared fluorescent dye to tumors that overexpress the epidermal growth factor receptor (EGFR) for fluorescence-guided surgery (FGS). We have developed and optimized the dose and time required for imaging small tumor burdens with minimal background fluorescence in real-time fluorescence-guided surgery of EGFR-expressing tumor xenografts in murine models. We demonstrate that the Centyrin-near-infrared dye conjugate (CNDC) binds selectively to human EGFR + cancer cells with an EC 50 of 2 nM, localizes to EGFR + tumor xenografts in athymic nude mice and that uptake of the dye in xenografts is significantly reduced when EGFR are blocked by preinjection of excess unlabeled Centyrin. Taken together, these data suggest that CNDCs can be used for intraoperative identification and surgical removal of EGFR-expressing lesions and that Centyrins targeted to other tumor-specific antigens should prove similarly useful in fluorescence guided surgery of cancer. In addition, we demonstrate that the CNDC is detected in the NIR region of the spectrum and can be utilized for fluorescence-guided surgery (FGS). In addition, we propose that with its eventual complete clearance from EGFR-negative tissues and its quantitative retention in the tumor mass for >24 h, a Centyrin-targeted NIR dye should provide excellent tumor contrast when injected at least 6-8 h before initiation of cancer surgery in human patients.

Identifying social factors amongst older individuals in linked electronic health records: An assessment in a population based study

PubMed Central

van Hoek, Albert J.; Walker, Jemma L.; Mathur, Rohini; Smeeth, Liam; Thomas, Sara L.

2017-01-01

Identification and quantification of health inequities amongst specific social groups is a pre-requisite for designing targeted healthcare interventions. This study investigated the recording of social factors in linked electronic health records (EHR) of individuals aged ≥65 years, to assess the potential of these data to identify the social determinants of disease burden and uptake of healthcare interventions. Methodology was developed for ascertaining social factors recorded on or before a pre-specified index date (01/01/2013) using primary care data from Clinical Practice Research Datalink (CPRD) linked to hospitalisation and deprivation data in a cross-sectional study. Social factors included: religion, ethnicity, immigration status, small area-level deprivation, place of residence (including communal establishments such as care homes), marital status and living arrangements (e.g. living alone, cohabitation). Each social factor was examined for: completeness of recording including improvements in completeness by using other linked EHR, timeliness of recording for factors that might change over time and their representativeness (compared with English 2011 Census data when available). Data for 591,037 individuals from 389 practices from England were analysed. The completeness of recording varied from 1.6% for immigration status to ~80% for ethnicity. Linkages provided the deprivation data (available for 82% individuals) and improved completeness of ethnicity recording from 55% to 79% (when hospitalisation data were added). Data for ethnicity, deprivation, living arrangements and care home residence were comparable to the Census data. For time-varying variables such as residence and living alone, ~60% and ~35% respectively of those with available data, had this information recorded within the last 5 years of the index date. This work provides methods to identify social factors in EHR relevant to older individuals and shows that factors such as ethnicity, deprivation, not living alone, cohabitation and care home residence can be ascertained using these data. Applying these methodologies to routinely collected data could improve surveillance programmes and allow assessment of health equity in specific healthcare studies. PMID:29190680

2WHSP: A multi-frequency selected catalogue of high energy and very high energy γ-ray blazars and blazar candidates

NASA Astrophysics Data System (ADS)

Chang, Y.-L.; Arsioli, B.; Giommi, P.; Padovani, P.

2017-02-01

Aims: High synchrotron peaked blazars (HSPs) dominate the γ-ray sky at energies higher than a few GeV; however, only a few hundred blazars of this type have been cataloged so far. In this paper we present the 2WHSP sample, the largest and most complete list of HSP blazars available to date, which is an expansion of the 1WHSP catalogue of γ-ray source candidates off the Galactic plane. Methods: We cross-matched a number of multi-wavelength surveys (in the radio, infrared and X-ray bands) and applied selection criteria based on the radio to IR and IR to X-ray spectral slopes. To ensure the selection of genuine HSPs, we examined the SED of each candidate and estimated the peak frequency of its synchrotron emission (νpeak) using the ASDC SED tool, including only sources with νpeak > 1015 Hz (equivalent to νpeak > 4 eV). Results: We have assembled the largest and most complete catalogue of HSP blazars to date, which includes 1691 sources. A number of population properties, such as infrared colours, synchrotron peak, redshift distributions, and γ-ray spectral properties have been used to characterise the sample and maximize completeness. We also derived the radio log N-log S distribution. This catalogue has already been used to provide seeds to discover new very high energy objects within Fermi-LAT data and to look for the counterparts of neutrino and ultra high energy cosmic ray sources, showing its potential for the identification of promising high-energy γ-ray sources and multi-messenger targets. Table 4 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/598/A17

Predicting Perceptions of Date Rape: An Examination of Perpetrator Motivation, Relationship Length, and Gender Role Beliefs

ERIC Educational Resources Information Center

Angelone, David J.; Mitchell, Damon; Lucente, Lauren

2012-01-01

The purpose of the current study is to examine the influence of multiple offender motivations (including no indication of a motivation), relationship length, and gender role beliefs on perceptions of a male-on-female date rape. A sample of 348 U.S. college students read a brief vignette depicting a date rape and completed a questionnaire regarding…

Targeted neonatal echocardiography services: need for standardized training and quality assurance.

PubMed

Finan, Emer; Sehgal, Arvind; Khuffash, Afif El; McNamara, Patrick J

2014-10-01

Targeted neonatal echocardiography refers to a focused assessment of myocardial performance and hemodynamics directed by a specific clinical question. It has become the standard of care in many parts of the world, but practice is variable, and there has been a lack of standardized training and evaluation to date. Targeted neonatal echocardiography was first introduced to Canada in 2006. The purpose of this study was to examine the characteristics of targeted neonatal echocardiography practice and training methods in Canadian neonatal intensive care units (NICUs). A total of 142 Canadian neonatologists were invited to participate in an online survey, which was conducted in September 2010. The survey consisted of questions related to the availability of targeted neonatal echocardiography, clinical indications, benefits and risks, and training methods. The overall survey response rate was 65%. Forty-eight respondents (34%) indicated that targeted neonatal echocardiography was available in their units, and the program was introduced within the preceding 1 to 5 years. In centers where it was unavailable, lack of on-site echocardiography expertise was cited as the major barrier to implementation. The most common indications for targeted neonatal echocardiography included evaluation of a hemodynamically significant ductus arteriosus, systemic or pulmonary blood flow, and response to cardiovascular treatments. Only 27% of respondents, working in centers where targeted neonatal echocardiography existed, actually performed the studies themselves; most individuals completed 11 to 20 studies per month. Almost half of the respondents said that training was available in their institutions, but methods of training and evaluation were inconsistent. Eighty-seven percent of respondents reported no formalized process for assessment of ongoing competency after the initial training period. Targeted neonatal echocardiography is becoming more widely available and is gaining acceptance in Canadian NICUs. Although training is provided in many institutions, the process is not well established, and formal evaluation is rarely performed. This study emphasizes the need for development of standards for formalized training, evaluation, and quality assurance. © 2014 by the American Institute of Ultrasound in Medicine.

Are All Interventions Created Equal? A Multi-Threat Approach to Tailoring Stereotype Threat Interventions

PubMed Central

Shapiro, Jenessa R.; Williams, Amy M.; Hambarchyan, Mariam

2013-01-01

To date, stereotype threat interventions have been considered interchangeable. Across 4 experiments, the present research demonstrates that stereotype threat interventions need to be tailored to the specific form of experienced stereotype threat to be effective. The Multi-Threat Framework (Shapiro & Neuberg, 2007) distinguishes between group-as-target stereotype threats—concerns that a stereotype-relevant performance will reflect poorly on the abilities of one’s group—and self-as-target stereotype threats—concerns that a stereotype-relevant performance will reflect poorly on one’s own abilities. The present experiments explored Black college students’ performance on diagnostic intelligence tests (Experiments 1 and 3) and women’s interest (Experiment 2) and performance (Experiment 4) in science, technology, engineering, and math (STEM). Across the 4 experiments, participants were randomly assigned to experience either a group-as-target or self-as-target stereotype threat. Experiments 1 and 2 revealed that role model interventions were successful at protecting only against group-as-target stereotype threats, and Experiments 3 and 4 revealed that self-affirmation interventions were successful at protecting only against self-as-target stereotype threats. The present research provides an experimental test of the Multi-Threat Framework across different negatively stereotyped groups (Black students, female students), different negatively stereotyped domains (general intelligence, STEM), and different outcomes (test performance, career interest). This research suggests that interventions should address the range of possible stereotype threats to effectively protect individuals against these threats. Through an appreciation of the distinct forms of stereotype threats and the ways in which interventions work to reduce them, this research aims to facilitate a more complete understanding of stereotype threat. PMID:23088232

Are all interventions created equal? A multi-threat approach to tailoring stereotype threat interventions.

PubMed

Shapiro, Jenessa R; Williams, Amy M; Hambarchyan, Mariam

2013-02-01

To date, stereotype threat interventions have been considered interchangeable. Across 4 experiments, the present research demonstrates that stereotype threat interventions need to be tailored to the specific form of experienced stereotype threat to be effective. The Multi-Threat Framework (Shapiro & Neuberg, 2007) distinguishes between group-as-target stereotype threats-concerns that a stereotype-relevant performance will reflect poorly on the abilities of one's group-and self-as-target stereotype threats-concerns that a stereotype-relevant performance will reflect poorly on one's own abilities. The present experiments explored Black college students' performance on diagnostic intelligence tests (Experiments 1 and 3) and women's interest (Experiment 2) and performance (Experiment 4) in science, technology, engineering, and math (STEM). Across the 4 experiments, participants were randomly assigned to experience either a group-as-target or self-as-target stereotype threat. Experiments 1 and 2 revealed that role model interventions were successful at protecting only against group-as-target stereotype threats, and Experiments 3 and 4 revealed that self-affirmation interventions were successful at protecting only against self-as-target stereotype threats. The present research provides an experimental test of the Multi-Threat Framework across different negatively stereotyped groups (Black students, female students), different negatively stereotyped domains (general intelligence, STEM), and different outcomes (test performance, career interest). This research suggests that interventions should address the range of possible stereotype threats to effectively protect individuals against these threats. Through an appreciation of the distinct forms of stereotype threats and the ways in which interventions work to reduce them, this research aims to facilitate a more complete understanding of stereotype threat. (c) 2013 APA, all rights reserved.

77 FR 13656 - Call for Papers: National Symposium on Moving Target Research

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... of moving target. There will be an accompanying poster session open for researchers and companies... dates/time 18:00 EDT): Draft Papers due April 2, 2012 Notification April 20, 2012 Poster abstracts due...

Effects of incubation temperatures on embryonic and larval survival in rainbow trout, Oncorhynchus mykiss

USDA-ARS?s Scientific Manuscript database

Incubation temperature is commonly used by hatcheries to manipulate hatch date in salmonids including rainbow trout (Oncorhynchus mykiss). Target dates for hatching often change during the incubation period and require a sudden adjustment in temperature. Although there are many studies charac...

PROGRAMMES IN PRINT 1966.

ERIC Educational Resources Information Center

CAVANAGH, PETER, COMP., ED.; JONES, CLIVE, COMP., ED.

APPROXIMATELY 1200 PROGRAMS ARE LISTED WITH TITLE, AUTHOR, DATE OF PUBLICATION, PUBLISHER, PRICE, COUNTRY OF ORIGIN, DATE OF LATEST EDITION IF REVISED, MONTHLY RENTAL PRICE, TYPE OF PROGRAM, NUMBER OF FRAMES, NUMBER OF PAGES IF A BOOK PROGRAM, TARGET POPULATION, STUDY TIME, AVAILABILITY FOR MACHINE USE, AND SUPPLEMENTARY MATERIALS WITH THEIR…

77 FR 65044 - Pennsylvania Disaster #PA-00054

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 10/18/2012. Incident: Cheltenham Township Condominium Complex Fire. Incident Period: 10/05/2012. Effective Date: 10/18/2012...: 07/18/2013. ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration...

Perceptions of adolescents, parents, and school personnel from a predominantly Cuban American community regarding dating and teen dating violence prevention.

PubMed

Gonzalez-Guarda, Rosa M; Cummings, Amanda M; Pino, Karen; Malhotra, Krithika; Becerra, Maria M; Lopez, Jessica E

2014-04-01

The purpose of this study was to explore perceptions of dating relationships and teen dating violence prevention within a predominantly Cuban American community in Miami-Dade County. Eight focus groups (n = 74 participants) with adolescents of Hispanic origin (n = 29), their parents (n = 29), and school personnel (n = 16) were conducted and analyzed using content analysis. Four themes characterized the nature and context of dating relationships among adolescents of Hispanic origin: YOLO -You Only Live Once, cultural unity but social division, dating is not going out, and the social environment challenges healthy relationships. The information generated from this study can be used to develop culturally tailored teen dating violence prevention programs targeting youth of Hispanic origin. © 2014 Wiley Periodicals, Inc.

50 CFR 660.40 - Overfished species rebuilding plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... biennial OYs, specifically the target date for rebuilding the stock to its MSY level and the harvest... Potential Ratio” or “SPR” harvest rate. (a) Bocaccio. The target year for rebuilding the southern bocaccio... annual SPR harvest rate of 77.7 percent. (b) Canary rockfish. The target year for rebuilding the canary...

75 FR 53952 - Gulf of Mexico Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-02

.../Annual Catch Target Control Rule Working Group. DATES: The first meeting will convene at 9 a.m. on Monday.... SUPPLEMENTARY INFORMATION: The Annual Catch Limit/Annual Catch Target Control Rule Working Group will review and... limit and annual catch target. For fisheries that have the annual catch limit allocated into sectors...

50 CFR 660.365 - Overfished species rebuilding plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... biennial OYs, specifically the target date for rebuilding the stock to its MSY level and the harvest... Potential Ratio” or “SPR” harvest rate. (a) Bocaccio. The target year for rebuilding the southern bocaccio... annual SPR harvest rate of 77.7 percent. (b) Canary rockfish. The target year for rebuilding the canary...

50 CFR 660.40 - Overfished species rebuilding plans.

Code of Federal Regulations, 2011 CFR

2011-10-01

... biennial ACLs, specifically the target date for rebuilding the stock to its MSY level and the harvest... Potential Ratio” or “SPR” harvest rate. (a) Bocaccio. The target year for rebuilding the bocaccio stock... bocaccio stock is an annual SPR harvest rate of 77.7 percent. (b) Canary rockfish. The target year for...

75 FR 1704 - Modification to Consolidated Return Regulation Permitting an Election To Treat a Liquidation of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... Modification to Consolidated Return Regulation Permitting an Election To Treat a Liquidation of a Target, Followed by a Recontribution to a New Target, as a Cross-Chain Reorganization AGENCY: Internal Revenue... a target, followed by a recontribution to a new reorganization. DATES: The correction is effective...

The pharmacology of second-generation chimeric antigen receptors.

PubMed

van der Stegen, Sjoukje J C; Hamieh, Mohamad; Sadelain, Michel

2015-07-01

Second-generation chimeric antigen receptors (CARs) retarget and reprogramme T cells to augment their antitumour efficacy. The combined activating and co-stimulatory domains incorporated in these CARs critically determine the function, differentiation, metabolism and persistence of engineered T cells. CD19-targeted CARs that incorporate CD28 or 4-1BB signalling domains are the best known to date. Both have shown remarkable complete remission rates in patients with refractory B cell malignancies. Recent data indicate that CD28-based CARs direct a brisk proliferative response and boost effector functions, whereas 4-1BB-based CARs induce a more progressive T cell accumulation that may compensate for less immediate potency. These distinct kinetic features can be exploited to further develop CAR-based T cell therapies for a variety of cancers. A new field of immunopharmacology is emerging.

Detection and Immunolabeling of Peroxisomal Proteins.

PubMed

Schrader, Tina A; Islinger, Markus; Schrader, Michael

2017-01-01

Peroxisomes are essential organelles in mammals which contribute to cellular lipid metabolism and redox homeostasis. The spectrum of their functions in human health and disease is far from being complete, and unexpected and novel roles of peroxisomes are being discovered. To date, those include novel biological roles in antiviral defence, as intracellular signaling platforms and as protective organelles in sensory cells. Furthermore, peroxisomes are part of a complex network of interacting subcellular compartments which involves metabolic cooperation, cross-talk and membrane contacts. As potentially novel peroxisomal proteins are continuously discovered, there is great interest in the verification of their peroxisomal localization. Here, we present protocols used successfully in our laboratory for the detection and immunolabeling of peroxisomal proteins in cultured mammalian cells. We present immunofluorescence and fluorescence-based techniques as well as reagents to determine peroxisome-specific targeting and localization of candidate proteins.

Capturing the benefits of complete streets.

DOT National Transportation Integrated Search

2015-12-01

Anecdotal information indicates that private investment and property value increases are associated : with featured Complete Streets projects. However, to date, little research has been done to confirm : these benefits. Much of the relevant literatur...

Tobacco industry targeting youth in Argentina.

PubMed

Braun, S; Mejia, R; Ling, P M; Pérez-Stable, E J

2008-04-01

Argentina has one of the highest cigarette smoking rates among both men and women in the Americas and no legislated restrictions on tobacco industry advertising. The tobacco industry has traditionally expanded markets by targeting adolescents and young adults. The objective of this study was to determine whether and how the tobacco industry promotes cigarettes to adolescents in Argentina. We conducted a systematic search of tobacco industry documents available through the internet dated between 1995 and 2004 using standard search terms to identify marketing strategies in Argentina. A selected review of the four leading newspapers and nine magazines with reported high readership among adolescents was completed. The selected print media were searched for tobacco images and these were classified as advertisements if associated with a commercial product or as a story if not. The tobacco industry used market segmentation as a strategy to target Argentinean consumers. British American Tobacco (BAT) undertook a young adult psychographic study and classified them as "progressives", "Jurassics" or "conservatives" and "crudos" or "spoiled brats". BAT marketed Lucky Strike to the "progressives" using Hollywood movies as a vehicle. The tobacco industry also targeted their national brands to the conservatives and linked these brands with "nationalistic values" in advertising campaigns. Philip Morris promoted Marlboro by sponsoring activities directed at young people and they launched the 10 cigarettes packet as a starter vehicle. The tobacco industry used psychographic segmentation of the population and developed advertising strategies focused on youth. Tobacco control researchers and advocates must be able to address these strategies in counter-marketing interventions.

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

PubMed Central

Eyquem, Justin; Mansilla-Soto, Jorge; Giavridis, Theodoros; van der Stegen, Sjoukje J. C.; Hamieh, Mohamad; Cunanan, Kristen M.; Odak, Ashlesha; Gönen, Mithat; Sadelain, Michel

2017-01-01

Chimeric antigen receptors (CARs) are synthetic receptors that redirect and reprogram T cells to mediate tumour rejection1. The most successful CARs used to date are those targeting CD19 (ref. 2), which offer the prospect of complete remission in patients with chemorefractory or relapsed B-cell malignancies3. CARs are typically transduced into the T cells of a patient using γ-retroviral4 vectors or other randomly integrating vectors5, which may result in clonal expansion, oncogenic transformation, variegated transgene expression and transcriptional silencing6–8. Recent advances in genome editing enable efficient sequence-specific interventions in human cells9,10, including targeted gene delivery to the CCR5 and AAVS1 loci11,12. Here we show that directing a CD19-specific CAR to the T-cell receptor α constant (TRAC) locus not only results in uniform CAR expression in human peripheral blood T cells, but also enhances T-cell potency, with edited cells vastly outperforming conventionally generated CAR T cells in a mouse model of acute lymphoblastic leukaemia. We further demonstrate that targeting the CAR to the TRAC locus averts tonic CAR signalling and establishes effective internalization and re-expression of the CAR following single or repeated exposure to antigen, delaying effector T-cell differentiation and exhaustion. These findings uncover facets of CAR immunobiology and underscore the potential of CRISPR/Cas9 genome editing to advance immunotherapies. PMID:28225754

Test Operations Procedure (TOP) 03-2-827 Test Procedures for Video Target Scoring Using Calibration Lights

DTIC Science & Technology

2016-04-04

Final 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Test Operations Procedure (TOP) 03-2-827 Test Procedures for Video Target Scoring Using...ABSTRACT This Test Operations Procedure (TOP) describes typical equipment and procedures to setup and operate a Video Target Scoring System (VTSS) to...lights. 15. SUBJECT TERMS Video Target Scoring System, VTSS, witness screens, camera, target screen, light pole 16. SECURITY

Signaling completion of a message transfer from an origin compute node to a target compute node

DOEpatents

Blocksome, Michael A [Rochester, MN; Parker, Jeffrey J [Rochester, MN

2011-05-24

Signaling completion of a message transfer from an origin node to a target node includes: sending, by an origin DMA engine, an RTS message, the RTS message specifying an application message for transfer to the target node from the origin node; receiving, by the origin DMA engine, a remote get message containing a data descriptor for the message and a completion notification descriptor, the completion notification descriptor specifying a local direct put transfer operation for transferring data locally on the origin node; inserting, by the origin DMA engine in an injection FIFO buffer, the data descriptor followed by the completion notification descriptor; transferring, by the origin DMA engine to the target node, the message in dependence upon the data descriptor; and notifying, by the origin DMA engine, the application that transfer of the message is complete in dependence upon the completion notification descriptor.

Signaling completion of a message transfer from an origin compute node to a target compute node

DOEpatents

Blocksome, Michael A [Rochester, MN

2011-02-15

Signaling completion of a message transfer from an origin node to a target node includes: sending, by an origin DMA engine, an RTS message, the RTS message specifying an application message for transfer to the target node from the origin node; receiving, by the origin DMA engine, a remote get message containing a data descriptor for the message and a completion notification descriptor, the completion notification descriptor specifying a local memory FIFO data transfer operation for transferring data locally on the origin node; inserting, by the origin DMA engine in an injection FIFO buffer, the data descriptor followed by the completion notification descriptor; transferring, by the origin DMA engine to the target node, the message in dependence upon the data descriptor; and notifying, by the origin DMA engine, the application that transfer of the message is complete in dependence upon the completion notification descriptor.

Visualizing Energy on Target: Molecular Dynamics Simulations

DTIC Science & Technology

2017-12-01

ARL-TR-8234 ● DEC 2017 US Army Research Laboratory Visualizing Energy on Target: Molecular Dynamics Simulations by DeCarlos E...return it to the originator. ARL-TR-8234● DEC 2017 US Army Research Laboratory Visualizing Energy on Target: Molecular Dynamics...REPORT TYPE Technical Report 3. DATES COVERED (From - To) 1 October 2015–30 September 2016 4. TITLE AND SUBTITLE Visualizing Energy on Target

VizieR Online Data Catalog: 280 one-opposition near Earth asteroids (Vaduvescu+, 2018)

NASA Astrophysics Data System (ADS)

Vaduvescu, O.; Hudin, L.; Mocnik, T.; Char, F.; Sonka, A.; Tudor, V.; Ordonez-Etxeberria, I.; Diaz Alfaro, M.; Ashley, R.; Errmann, R.; Short, P.; Moloceniuc, A.; Cornea, R.; Inceu, V.; Zavoianu, D.; Popescu, M.; Curelaru, L.; Mihalea, S.; Stoian, A.-M.; Boldea, A.; Toma, R.; Fields, L.; Grigore, V.; Stoev, H.; Lopez-Martinez, F.; Humphries, N.; Sowicka, P.; Ramanjooloo, Y.; Manilla-Robles, A.; Riddick, F. C.; Jimenez-Lujan, F.; Mendez, J.; Aceituno, F.; Sota, A.; Jones, D.; Hidalgo, S.; Murabito, S.; Oteo, I.; Bongiovanni, A.; Zamora, O.; Pyrzas, S.; Tanausu, R.; Font, J.; Bereciartua, A.; Perez-Fournon, I.; Martinez-Vazquez, C. E.; Monelli, M.; Cicuendez, L.; Monteagudo, L.; Agulli, I.; Bouy, H.; Huelamo, N.; Monguio, M.; Gaensicke, B. T.; Steeghs, D.; Gentile-Fusillo, N. P.; Hollands, M. A.; Toloza, O.; Manser, C. J.; Dhillon, V.; Sahman, D.; Fitzsimmons, A.; McNeill, A.; Thompson, A.; Tabor, M.; Murphy, D. N. A.; Davies, J.; Snodgrass, C.; Triaud, A. H. M. J.; Groot, P. J.; Macfarlane, S.; Peletier, R.; Sen, S.; Ikiz, T.; Hoekstra, H.; Herbonnet, R.; Koehlinger, F.; Greimel, R.; Afonso, A.; Parker, Q. A.; Kong, A. K. H.; Bassa, C.; Pleunis, Z.

2017-10-01

Table 2 lists the observing log of the EURONEAR 2013-2016 one-opposition near Earth asteroids (NEAs) recovery project. The Tables includes 457 observed fields (437 using the INT, 12 using the WHT and 4 using the OGS). We ordered the table based on the asteroid designation (first column) then the observing date (start night), listing the apparent magnitude V (according to MPC ephemerides), the proper motion miu and the positional uncertainty of the targets (as shown on the observing date by MPC at 3σ level), the number of acquired images (including nearby fields), and the exposure time (in seconds). In the last three columns we list the current status of the targets (as classified in the paper by Aug 2017), the MPS publication that includes our recovery, and some comments that can include the PHA classification, other used telescopes (WHT or OGS), the track-and-stack technique (TS, whenever used), other possible external stations (MPC observatory code) and the date of later recovery (given only for later recoveries when we were unable to find the targets or for joined simultaneous recoveries). (1 data file).

Targeting Chemerin Receptor CMKLR1 in Multiple Sclerosis

DTIC Science & Technology

2012-09-01

CONTRACTING ORGANIZATION: Palo Alto Institute for Research & Education, Inc. Palo Alto, CA 94304-1290 REPORT DATE : September 2012 TYPE OF...if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY...September 2012 2. REPORT TYPE Annual 3. DATES COVERED (From - To) 29-August-2011-28-August-2012 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER

A Partnership Training Program: Studying Targeted Drug Delivery Using Nanoparticles In Breast Cancer Diagnosis and Therapy

DTIC Science & Technology

2011-10-01

REPORT DATE : TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command...DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE 5a...We have also developed transferrin attached protein nanospheres with silicon coating, doped with rare earth oxide and rhodamine B isothiocyanate

Programmable Logic Controller Modification Attacks for use in Detection Analysis

DTIC Science & Technology

2014-03-27

and J. Lowe, “The Myths and Facts Behind Cyber Security Risks for Industrial Control Systems ,” in Proceedings of the VDE Kongress, vol. 116, 2004. [13...Feb 2014 Date 20 Feb 2014 Date 20 Feb 2014 Date AFIT-ENG-14-M-66 Abstract Unprotected Supervisory Control and Data Acquisition (SCADA) systems offer...control and monitor physical industrial processes. Although attacks targeting SCADA systems have increased, there has been little work exploring the

The influence of HIV disease events/stages on smoking attitudes and behaviors: project STATE (Study of Tobacco Attitudes and Teachable Events).

PubMed

Vidrine, Damon J; Fletcher, Faith E; Buchberg, Meredith K; Li, Yisheng; Arduino, Roberto C; Gritz, Ellen R

2014-02-11

Given the increase in life expectancy among HIV-positive individuals attributable to antiretroviral therapies, cigarette smoking now represents one of the most salient health risks confronting the HIV-positive population. Despite this risk, very few efforts to date have been made to target persons living with HIV for smoking cessation treatment, and no efforts have been made to explore the role of cognitions and HIV disease events/stages on smoking outcomes. The purpose of the study, Project STATE (Study of Tobacco Attitudes and Teachable Events), is to prospectively examine the relationship between HIV events/stages, perceived impact of HIV disease, attitudes about cigarette smoking, and smoking behaviors. This study employs a prospective design. Patients are recruited at the time of their first physician visit at a large inner city HIV-clinic--Thomas Street Health Center (TSHC). Consenting participants then complete a baseline assessment. All participants are offered standard care smoking cessation treatment. Follow-up assessments are completed on four subsequent occasions: 3, 6, 9, and 12 months post-baseline. These follow-up assessments are scheduled to coincide with routine clinic appointments with their TSHC physicians. In addition, each participant is given a prepaid cell phone at the time of enrollment and asked to complete brief phone assessments weekly for the first three months of the study period. By evaluating events/stages of HIV disease as potential teaching moments for smoking cessation, findings from this study could be used to develop treatments tailored to an individual's stage of HIV disease. This study design will enable us to carefully track changes in smoking behavior over time, and to link these changes to both the course of HIV disease and/or to the participant's' perceived impact of HIV. By identifying optimal time points for intervention, the findings from this study will have the potential to maximize the efficiency and efficacy of cessation treatments delivered in resource-limited settings. In addition, the findings will be instrumental in identifying specific constructs that should be targeted for intervention and will provide a strong foundation for the development of future cessation interventions targeting smokers living with HIV/AIDS.

Clinical Investigation Program RCS-MED-300 (R1)

DTIC Science & Technology

1988-09-30

34, pluse one letter to the editor, and one article published (1986 and 1987). . .. ..... .......... .. . • m mmm il lm9 DETAIL SUMMARY SHEET DATE: 1 ...SUMMARY SHEET DATE: 1 October 1988 PROTOCOL #: 87/08 STATUS: Completed TITLE: A Pilot Study on Effect of Nicotine and Cigarette Smoking on...Clinical Immunology, Anaheim, California in March 1988. 29 DETAIL SUMMARY SHEET DATE: 1 October 1988 PROTOCOL #: 87/12 STATUS: Terminated TITLE: Effect

75 FR 35919 - Investment Company Advertising: Target Date Retirement Fund Names and Marketing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... be misleading. The amendments are intended to provide enhanced information to investors concerning... intended as the approximate year of an investor's retirement, and an investor may use the date contained in... manner reasonably calculated to draw investor attention to the information is the same presentation...

29 CFR 4010.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., earliest retirement age at valuation date, ERISA, expected retirement age (XRA), fair market value, IRS...). Fair market value of the plan's assets means the fair market value of the plan's assets at the end of... not adopted a closing date, the calendar year. Funding target means, with respect to a plan for a plan...

28 CFR 42.521 - Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... in existing facilities where other methods are effective in achieving compliance with paragraph (a... this section within ninety days of the effective date of this subpart. However, where structural... completed no later than three years from the effective date of this subpart. If structural changes to...

28 CFR 42.521 - Existing facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... in existing facilities where other methods are effective in achieving compliance with paragraph (a... this section within ninety days of the effective date of this subpart. However, where structural... completed no later than three years from the effective date of this subpart. If structural changes to...

28 CFR 42.521 - Existing facilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... in existing facilities where other methods are effective in achieving compliance with paragraph (a... this section within ninety days of the effective date of this subpart. However, where structural... completed no later than three years from the effective date of this subpart. If structural changes to...

28 CFR 42.521 - Existing facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... in existing facilities where other methods are effective in achieving compliance with paragraph (a... this section within ninety days of the effective date of this subpart. However, where structural... completed no later than three years from the effective date of this subpart. If structural changes to...

28 CFR 42.521 - Existing facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... in existing facilities where other methods are effective in achieving compliance with paragraph (a... this section within ninety days of the effective date of this subpart. However, where structural... completed no later than three years from the effective date of this subpart. If structural changes to...

Predictors of Substance Abuse Assessment and Treatment Completion for Parents Involved with Child Welfare: One State's Experience in Matching across Systems.

PubMed

Traube, Dorian E; He, Amy S; Zhu, Limei; Scalise, Christine; Richardson, Tyrone

2015-01-01

To date, few studies have examined the effect of interagency collaboration on substance abuse assessment ity of Southern California and treatment completion for parents who are involved in child welfare. The purpose of this paper is to: (1) describe a statewide, interagency collaborative program aimed at providing targeted substance abuse assessment and treatment to parents engaged in the child welfare system; (2) document the specialized assessment and treatment outcomes for parents engaged through this collaborative program; and (3) determine factors related to successful treatment completion for parents involved in the child welfare system. This is a retrospective study of an open cohort of 13,829 individuals admitted to the New Jersey Child Protection Substance Abuse Initiative (CPSAI) program from October 1, 2009, through September 30, 2010. Data were drawn from two unique administrative data sources. Multivariate Cox regression models were used to explore factors related to successfil treatment completion for parents involved in the child welfare system. Trend analysis for the total sample in the CPSAI program revealed that, of the 10,909 individuals who received a CPSAI assessment, 59% were referred to treatment. Of those referred to treatment, 40% enrolled in a treatment program. Once enrolled in a treatment program, 55% completed or were in the process of completing substance abuse treatment. These findings suggest that when adequate screening and treatment is available through a streamlined process, many of the ethnic and gender disparities present among other populations of individuals seeking treatment are minimized. Utilizing inherent child welfare case factors appears to be an important motivating element that aids parents during the assessment and treatment process.

Dating violence and girls in the juvenile justice system.

PubMed

Kelly, Patricia J; Cheng, An-Lin; Peralez-Dieckmann, Esther; Martinez, Elisabeth

2009-09-01

The purpose of this study is to explore the prevalence and associated behaviors of dating violence among a population of girls in the juvenile justice system. A sample of 590 girls from an urban juvenile justice system completed a questionnaire assessing attitudes and self-efficacy about and occurrence of dating violence. The analysis developed a random effect model to determine a risk profile for dating violence. The strongest predictors of dating violence were (a) initial sexual experience at age 13 or earlier, (b) unwillingness of initial sexual experience, (c) drug use, and (d) low self-efficacy about preventing dating violence. The high prevalence of dating violence and associated behaviors among participants suggests the importance of implementing primary prevention programs to assist preteen girls in delaying initial sexual intercourse and in learning techniques to prevent dating violence.

KSC-08pd3252

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lifts the Flight Support System carrier from the payload canister toward a stand in the PHSF. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

KSC-08pd3251

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lifts the Flight Support System carrier from the payload canister. It will be moved to a stand in the PHSF. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

KSC-08pd3185

NASA Image and Video Library

2008-10-14

CAPE CANAVERAL, Fla. – The deep-red sunset sky puts Launch pad 39A in silhouette. Space shuttle Atlantis is on the pad. Atlantis’ October target launch date for the STS-125 Hubble Space Telescope servicing mission was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. In the interim, Atlantis will be rolled back to the Vehicle Assembly Building until a new target launch date can be set for the mission in 2009. Photo credit: NASA/Troy Cryder

Examining the association between bullying and adolescent concerns about teen dating violence.

PubMed

Debnam, Katrina J; Johnson, Sarah L; Bradshaw, Catherine P

2014-07-01

The school environment is an important context for understanding risk factors for teen dating violence. This study seeks to add to the growing literature base linking adolescent experiences with bullying and involvement with teen dating violence. Data were collected from 27,074 adolescents at 58 high schools via a Web-based survey. Three-level hierarchical linear models indicated that adolescents who had been bullied were more concerned about both physical and emotional dating violence among students at their school. Schools that were perceived by students as safer were rated as having lower levels of teen dating violence. Older students and male students consistently reported greater concerns about dating violence. These results suggest that adolescents who experience bullying may also have concerns about violence in teen dating relationships. Findings also indicate that schools perceived as being unsafe may be an important context for targeting dating violence prevention efforts. © 2014, American School Health Association.

Prediction of accrual closure date in multi-center clinical trials with discrete-time Poisson process models.

PubMed

Tang, Gong; Kong, Yuan; Chang, Chung-Chou Ho; Kong, Lan; Costantino, Joseph P

2012-01-01

In a phase III multi-center cancer clinical trial or a large public health study, sample size is predetermined to achieve desired power, and study participants are enrolled from tens or hundreds of participating institutions. As the accrual is closing to the target size, the coordinating data center needs to project the accrual closure date on the basis of the observed accrual pattern and notify the participating sites several weeks in advance. In the past, projections were simply based on some crude assessment, and conservative measures were incorporated in order to achieve the target accrual size. This approach often resulted in excessive accrual size and subsequently unnecessary financial burden on the study sponsors. Here we proposed a discrete-time Poisson process-based method to estimate the accrual rate at time of projection and subsequently the trial closure date. To ensure that target size would be reached with high confidence, we also proposed a conservative method for the closure date projection. The proposed method was illustrated through the analysis of the accrual data of the National Surgical Adjuvant Breast and Bowel Project trial B-38. The results showed that application of the proposed method could help to save considerable amount of expenditure in patient management without compromising the accrual goal in multi-center clinical trials. Copyright © 2012 John Wiley & Sons, Ltd.

50 CFR 15.25 - Permits for personal pets.

Code of Federal Regulations, 2013 CFR

2013-10-01

... the origin of the exotic bird, including; (i) Country of origin; and (ii) A description and... seller with name and address of seller, date of sale, species, and other identifying information on the... transfer, species and hatch date. (b) Issuance criteria. Upon receiving an application completed in...

50 CFR 15.25 - Permits for personal pets.

Code of Federal Regulations, 2012 CFR

2012-10-01

... the origin of the exotic bird, including; (i) Country of origin; and (ii) A description and... seller with name and address of seller, date of sale, species, and other identifying information on the... transfer, species and hatch date. (b) Issuance criteria. Upon receiving an application completed in...

50 CFR 15.25 - Permits for personal pets.

Code of Federal Regulations, 2014 CFR

2014-10-01

... the origin of the exotic bird, including; (i) Country of origin; and (ii) A description and... seller with name and address of seller, date of sale, species, and other identifying information on the... transfer, species and hatch date. (b) Issuance criteria. Upon receiving an application completed in...

Targeting Palmitoyl Acyltransferases in Mutant NRAS-Driven Melanoma

DTIC Science & Technology

2014-08-01

Ph.D. CONTRACTING ORGANIZATION: Massachusetts General Hospital Boston, MA 02114 REPORT DATE: August 2014 TYPE OF REPORT: Annual PREPARED...RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE August 2014 2. REPORT TYPE Annual 3. DATES COVERED 1 Aug 2013 - 31 Jul 2014 4. TITLE AND...lysophosphatidylcholine acyltransferase 2 0 25 2 4 COMT catechol O-methyltransferase 2 24 16 8 HEATR3 HEAT repeat-containing protein 3 0 21 6 1 ZDHHC20 probable

Targeted Magnetic Hyperthermia for Lung Cancer

DTIC Science & Technology

2013-09-01

REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE 2. REPORT TYPE...3. DATES COVERED 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...been reported to date . Using various in vitro and in vivo assays, we evaluated the ability of SPIO NP-mediated magnetic hyperthermia to effectively

77 FR 25889 - Drawbridge Operation Regulations; Niantic River, Niantic, CT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... 20 nights to facilitate completion of work on machinery and the lift span. DATES: This deviation is... completion of machinery installation and lift span work at the new Niantic River RR Bridge. To facilitate...

40 CFR 60.1160 - Who must complete the operator training course? By when?

Code of Federal Regulations, 2012 CFR

2012-07-01

... types of employees must complete the EPA or State-approved operator training course: (1) Chief facility... initial startup. (2) December 6, 2001. (3) The date before an employee assumes responsibilities that...

40 CFR 60.1160 - Who must complete the operator training course? By when?

Code of Federal Regulations, 2010 CFR

2010-07-01

... types of employees must complete the EPA or State-approved operator training course: (1) Chief facility... initial startup. (2) December 6, 2001. (3) The date before an employee assumes responsibilities that...

40 CFR 60.1160 - Who must complete the operator training course? By when?

Code of Federal Regulations, 2014 CFR

2014-07-01

... types of employees must complete the EPA or State-approved operator training course: (1) Chief facility... initial startup. (2) December 6, 2001. (3) The date before an employee assumes responsibilities that...

40 CFR 60.1160 - Who must complete the operator training course? By when?

Code of Federal Regulations, 2011 CFR

2011-07-01

... types of employees must complete the EPA or State-approved operator training course: (1) Chief facility... initial startup. (2) December 6, 2001. (3) The date before an employee assumes responsibilities that...

40 CFR 60.1160 - Who must complete the operator training course? By when?

Code of Federal Regulations, 2013 CFR

2013-07-01

... types of employees must complete the EPA or State-approved operator training course: (1) Chief facility... initial startup. (2) December 6, 2001. (3) The date before an employee assumes responsibilities that...

WFIRST: Exoplanet Target Selection and Scheduling with Greedy Optimization

NASA Astrophysics Data System (ADS)

Keithly, Dean; Garrett, Daniel; Delacroix, Christian; Savransky, Dmitry

2018-01-01

We present target selection and scheduling algorithms for missions with direct imaging of exoplanets, and the Wide Field Infrared Survey Telescope (WFIRST) in particular, which will be equipped with a coronagraphic instrument (CGI). Optimal scheduling of CGI targets can maximize the expected value of directly imaged exoplanets (completeness). Using target completeness as a reward metric and integration time plus overhead time as a cost metric, we can maximize the sum completeness for a mission with a fixed duration. We optimize over these metrics to create a list of target stars using a greedy optimization algorithm based off altruistic yield optimization (AYO) under ideal conditions. We simulate full missions using EXOSIMS by observing targets in this list for their predetermined integration times. In this poster, we report the theoretical maximum sum completeness, mean number of detected exoplanets from Monte Carlo simulations, and the ideal expected value of the simulated missions.

Shifting white pox aetiologies affecting Acropora palmata in the Florida Keys, 1994–2014

PubMed Central

Berry, Brett; Park, Andrew; Kemp, Dustin W.; Kemp, Keri M.; Lipp, Erin K.; Porter, James W.

2016-01-01

We propose ‘the moving target hypothesis’ to describe the aetiology of a contemporary coral disease that differs from that of its historical disease state. Hitting the target with coral disease aetiology is a complex pursuit that requires understanding of host and environment, and may lack a single pathogen solution. White pox disease (WPX) affects the Caribbean coral Acropora palmata. Acroporid serratiosis is a form of WPX for which the bacterial pathogen (Serratia marcescens) has been established. We used long-term (1994–2014) photographic monitoring to evaluate historical and contemporary epizootiology and aetiology of WPX affecting A. palmata at eight reefs in the Florida Keys. Ranges of WPX prevalence over time (0–71.4%) were comparable for the duration of the 20-year study. Whole colony mortality and disease severity were high in historical (1994–2004), and low in contemporary (2008–2014), outbreaks of WPX. Acroporid serratiosis was diagnosed for some historical (1999, 2003) and contemporary (2012, 2013) outbreaks, but this form of WPX was not confirmed for all WPX cases. Our results serve as a context for considering aetiology as a moving target for WPX and other coral diseases for which pathogens are established and/or candidate pathogens are identified. Coral aetiology investigations completed to date suggest that changes in pathogen, host and/or environment alter the disease state and complicate diagnosis. PMID:26880837

Shifting white pox aetiologies affecting Acropora palmata in the Florida Keys, 1994-2014.

PubMed

Sutherland, Kathryn P; Berry, Brett; Park, Andrew; Kemp, Dustin W; Kemp, Keri M; Lipp, Erin K; Porter, James W

2016-03-05

We propose 'the moving target hypothesis' to describe the aetiology of a contemporary coral disease that differs from that of its historical disease state. Hitting the target with coral disease aetiology is a complex pursuit that requires understanding of host and environment, and may lack a single pathogen solution. White pox disease (WPX) affects the Caribbean coral Acropora palmata. Acroporid serratiosis is a form of WPX for which the bacterial pathogen (Serratia marcescens) has been established. We used long-term (1994-2014) photographic monitoring to evaluate historical and contemporary epizootiology and aetiology of WPX affecting A. palmata at eight reefs in the Florida Keys. Ranges of WPX prevalence over time (0-71.4%) were comparable for the duration of the 20-year study. Whole colony mortality and disease severity were high in historical (1994-2004), and low in contemporary (2008-2014), outbreaks of WPX. Acroporid serratiosis was diagnosed for some historical (1999, 2003) and contemporary (2012, 2013) outbreaks, but this form of WPX was not confirmed for all WPX cases. Our results serve as a context for considering aetiology as a moving target for WPX and other coral diseases for which pathogens are established and/or candidate pathogens are identified. Coral aetiology investigations completed to date suggest that changes in pathogen, host and/or environment alter the disease state and complicate diagnosis. © 2016 The Author(s).

Substance Use as a Longitudinal Predictor of the Perpetration of Teen Dating Violence

ERIC Educational Resources Information Center

Temple, Jeff R.; Shorey, Ryan C.; Fite, Paula; Stuart, Gregory L.; Le, Vi Donna

2013-01-01

The prevention of teen dating violence is a major public health priority. However, the dearth of longitudinal studies makes it difficult to develop programs that effectively target salient risk factors. Using a school-based sample of ethnically diverse adolescents, this longitudinal study examined whether substance use (alcohol, marijuana, and…

7 CFR 275.17 - State corrective action plan.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 4 2011-01-01 2011-01-01 false State corrective action plan. 275.17 Section 275.17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... be taken, the expected outcome of each action, the target date for each action, and the date by which...

7 CFR 275.17 - State corrective action plan.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false State corrective action plan. 275.17 Section 275.17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... be taken, the expected outcome of each action, the target date for each action, and the date by which...

Targeted, On-Demand Charge Conversional Nanotherapeutics for Advanced Prostate Cancer

DTIC Science & Technology

2015-09-01

Figure 3 . The fluorescent activated cell sorting (FACS) analysis of cellular uptake of Cy5.5 loaded Pep -PEG-PTMC nanoparticles after incubation with...PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE September 2015 2. REPORT TYPE Annual 3 . DATES COVERED 29 Aug 2014 – 28 Aug...

78 FR 26383 - Environmental Assessment of the Proposed Increase in Operation, Maintenance and Replacement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

... regulating ponds to accommodate the changing pattern of water demand and increased urbanization. DATES: Date... Water Efficiency Project AGENCY: Central Utah Project Completion Act Office, Interior. ACTION: Notice of... amended, the Department of the Interior, the Central Utah Water Conservancy District, and the Utah...

48 CFR 50.103-4 - Facts and evidence.

Code of Federal Regulations, 2010 CFR

2010-10-01

... before Federal income taxes. (5) A statement of the contractor's understanding of why the request's... certified by a certified public accountant, as necessary to support the request's monetary elements. (8) A... completion date of the last contract involved. (7) A statement of the amount of any tax refunds to date, and...

40 CFR 63.345 - Provisions for new and reconstructed sources.

Code of Federal Regulations, 2014 CFR

2014-07-01

... completion dates of the construction or reconstruction; (vi) The anticipated date of (initial) startup of the affected source; (vii) The type of process operation to be performed (hard or decorative chromium... startup had not occurred before January 25, 1995, the notification shall be submitted as soon as...

40 CFR 63.345 - Provisions for new and reconstructed sources.

Code of Federal Regulations, 2012 CFR

2012-07-01

... completion dates of the construction or reconstruction; (vi) The anticipated date of (initial) startup of the affected source; (vii) The type of process operation to be performed (hard or decorative chromium... startup had not occurred before January 25, 1995, the notification shall be submitted as soon as...

40 CFR 63.345 - Provisions for new and reconstructed sources.

Code of Federal Regulations, 2013 CFR

2013-07-01

... completion dates of the construction or reconstruction; (vi) The anticipated date of (initial) startup of the affected source; (vii) The type of process operation to be performed (hard or decorative chromium... startup had not occurred before January 25, 1995, the notification shall be submitted as soon as...

40 CFR 75.4 - Compliance dates.

Code of Federal Regulations, 2011 CFR

2011-07-01

....e., SO2 or NOX, as applicable): (A) Only if the relative accuracy test audit (RATA) of the high... that all certification tests are completed no later than the following dates (except as provided in... an oil-fired Phase II unit, January 1, 1995, except that installation and certification tests for...

76 FR 66768 - Puerto Rico Disaster #PR-00016

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... declaration of a major disaster for the Commonwealth of Puerto Rico (FEMA-4040-DR), dated 10/ 18/2011. Incident: Tropical Storm Maria. Incident Period: 09/08/2011 through 09/14/2011. Effective Date: 10/18/2011...: 07/18/2012. ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration...

26 CFR 1.381(c)(2)-1 - Earnings and profits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(2)-1 Earnings and profits. (a) In... profits, after the date of distribution or transfer and before the completion of the reorganization or... maintaining two separate earnings and profits accounts after the date of distribution or transfer. The first...

Randomized Comparison of Mobile and Web-Tools to Provide Dementia Risk Reduction Education: Use, Engagement and Participant Satisfaction

PubMed Central

O'Connor, Elodie; Hatherly, Chris

2014-01-01

Background Encouraging middle-aged adults to maintain their physical and cognitive health may have a significant impact on reducing the prevalence of dementia in the future. Mobile phone apps and interactive websites may be one effective way to target this age group. However, to date there has been little research investigating the user experience of dementia risk reduction tools delivered in this way. Objective The aim of this study was to explore participant engagement and evaluations of three different targeted smartphone and Web-based dementia risk reduction tools following a four-week intervention. Methods Participants completed a Web-based screening questionnaire to collect eligibility information. Eligible participants were asked to complete a Web-based baseline questionnaire and were then randomly assigned to use one of the three dementia risk reduction tools for a period of four weeks: (1) a mobile phone application; (2) an information-based website; and (3) an interactive website. User evaluations were obtained via a Web-based follow-up questionnaire after completion of the intervention. Results Of 415 eligible participants, 370 (89.16%) completed the baseline questionnaire and were assigned to an intervention group; 200 (54.05%) completed the post-intervention questionnaire. The average age of participants was 52 years, and 149 (75%) were female. Findings indicated that participants from all three intervention groups reported a generally positive impression of the tools across a range of domains. Participants using the information-based website reported higher ratings of their overall impression of the tool, F2,191=4.12, P=.02; how interesting the information was, F2,189=3.53, P=.03; how helpful the information was, F2,192=4.15, P=.02; and how much they learned, F2,188=3.86, P=.02. Group differences were significant between the mobile phone app and information-based website users, but not between the interactive website users and the other two groups. Additionally, participants using the information-based website reported significantly higher scores on their ratings of the ease of navigation, F2,190=4.20, P=.02, than those using the mobile phone app and the interactive website. There were no significant differences between groups on ratings of ease of understanding the information, F2,188=0.27, P=.76. Most participants from each of the three intervention groups indicated that they intended to keep using the dementia risk reduction eHealth tool. Conclusions Overall, results indicated that while participants across all three intervention groups reported a generally positive experience with the targeted dementia risk reduction tools, participants using the information-based website provided a more favorable evaluation across a range of areas than participants using the mobile phone app. Further research is required to investigate whether targeted dementia risk reduction tools, in the form of interactive websites and mobile apps, can be improved to provide benefits above those gained by providing static information alone. PMID:26543904

Randomized Comparison of Mobile and Web-Tools to Provide Dementia Risk Reduction Education: Use, Engagement and Participant Satisfaction.

PubMed

O'Connor, Elodie; Farrow, Maree; Hatherly, Chris

2014-01-01

Encouraging middle-aged adults to maintain their physical and cognitive health may have a significant impact on reducing the prevalence of dementia in the future. Mobile phone apps and interactive websites may be one effective way to target this age group. However, to date there has been little research investigating the user experience of dementia risk reduction tools delivered in this way. The aim of this study was to explore participant engagement and evaluations of three different targeted smartphone and Web-based dementia risk reduction tools following a four-week intervention. Participants completed a Web-based screening questionnaire to collect eligibility information. Eligible participants were asked to complete a Web-based baseline questionnaire and were then randomly assigned to use one of the three dementia risk reduction tools for a period of four weeks: (1) a mobile phone application; (2) an information-based website; and (3) an interactive website. User evaluations were obtained via a Web-based follow-up questionnaire after completion of the intervention. Of 415 eligible participants, 370 (89.16%) completed the baseline questionnaire and were assigned to an intervention group; 200 (54.05%) completed the post-intervention questionnaire. The average age of participants was 52 years, and 149 (75%) were female. Findings indicated that participants from all three intervention groups reported a generally positive impression of the tools across a range of domains. Participants using the information-based website reported higher ratings of their overall impression of the tool, F2,191=4.12, P=.02; how interesting the information was, F2,189=3.53, P=.03; how helpful the information was, F2,192=4.15, P=.02; and how much they learned, F2,188=3.86, P=.02. Group differences were significant between the mobile phone app and information-based website users, but not between the interactive website users and the other two groups. Additionally, participants using the information-based website reported significantly higher scores on their ratings of the ease of navigation, F2,190=4.20, P=.02, than those using the mobile phone app and the interactive website. There were no significant differences between groups on ratings of ease of understanding the information, F2,188=0.27, P=.76. Most participants from each of the three intervention groups indicated that they intended to keep using the dementia risk reduction eHealth tool. Overall, results indicated that while participants across all three intervention groups reported a generally positive experience with the targeted dementia risk reduction tools, participants using the information-based website provided a more favorable evaluation across a range of areas than participants using the mobile phone app. Further research is required to investigate whether targeted dementia risk reduction tools, in the form of interactive websites and mobile apps, can be improved to provide benefits above those gained by providing static information alone.

76 FR 24081 - Notice of Commission Determination

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... affect any other gas well development projects targeting the Marcellus or Utica shale formations that the... regarding the requirement for review and approval of natural gas well development projects targeting the Antes, Burket, Geneseo, Mandata, Middlesex, Needmore, or Rhinestreet shale formations. DATES: April 21...

Enhancing Targeted Therapy for Myeloproliferative Neoplasms

DTIC Science & Technology

2013-10-01

Myeloproliferative Neoplasms PRINCIPAL INVESTIGATOR: Gary W. Reuther CONTRACTING...2. REPORT TYPE Annual 3. DATES COVERED 30 2012-2 2013 4. TITLE AND SUBTITLE Enhancing Targeted Therapy for Myeloproliferative Neoplasms ...AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Myeloproliferative neoplasms

Early Results from the Qweak Experiment

NASA Astrophysics Data System (ADS)

Androic, D.; Armstrong, D. S.; Asaturyan, A.; Averett, T.; Balewski, J.; Beaufait, J.; Beminiwattha, R. S.; Benesch, J.; Benmokhtar, F.; Birchall, J.; Carlini, R. D.; Cates, G. D.; Cornejo, J. C.; Covrig, S.; Dalton, M. M.; Davis, C. A.; Deconinck, W.; Diefenbach, J.; Dowd, J. F.; Dunne, J. A.; Dutta, D.; Duvall, W. S.; Elaasar, M.; Falk, W. R.; Finn, J. M.; Forest, T.; Gaskell, D.; Gericke, M. T. W.; Grames, J.; Gray, V. M.; Grimm, K.; Guo, F.; Hoskins, J. R.; Johnston, K.; Jones, D.; Jones, M.; Jones, R.; Kargiantoulakis, M.; King, P. M.; Korkmaz, E.; Kowalski, S.; Leacock, J.; Leckey, J.; Lee, A. R.; Lee, J. H.; Lee, L.; MacEwan, S.; Mack, D.; Magee, J. A.; Mahurin, R.; Mammei, J.; Martin, J.; McHugh, M. J.; Meekins, D.; Mei, J.; Michaels, R.; Micherdzinska, A.; Mkrtchyan, A.; Mkrtchyan, H.; Morgan, N.; Myers, K. E.; Narayan, A.; Ndukum, L. Z.; Nelyubin, V.; Nuruzzaman; van Oers, W. T. H.; Opper, A. K.; Page, S. A.; Pan, J.; Paschke, K.; Phillips, S. K.; Pitt, M. L.; Poelker, M.; Rajotte, J. F.; Ramsay, W. D.; Roche, J.; Sawatzky, B.; Seva, T.; Shabestari, M. H.; Silwal, R.; Simicevic, N.; Smith, G. R.; Solvignon, P.; Spayde, D. T.; Subedi, A.; Subedi, R.; Suleiman, R.; Tadevosyan, V.; Tobias, W. A.; Tvaskis, V.; Waidyawansa, B.; Wang, P.; Wells, S. P.; Wood, S. A.; Yang, S.; Young, R. D.; Zhamkochyan, S.

2014-03-01

A subset of results from the recently completed Jefferson Lab Qweak experiment are reported. This experiment, sensitive to physics beyond the Standard Model, exploits the small parity-violating asymmetry in elastic e{{p}} scattering to provide the first determination of the proton's weak charge Q_w^p. The experiment employed a 180 μA longitudinally polarized 1.16 GeV electron beam on a 35 cm long liquid hydrogen target. Scattered electrons in the angular range 6° < θ < 12° corresponding to Q2 = 0.025 GeV2 were detected in eight Cerenkov detectors arrayed symmetrically around the beam axis. The goals of the experiment were to provide a measure of e{{p}} to 4.2% (combined statisstatistical and systematic error), which implies a measure of sin2(θw) at the level of 0.3%, and to help constrain the vector weak quark charges C1u and C1d. The experimental method is described, with particular focus on the challenges associated with the world's highest power LH2 target. The new constraints on C1u and C1d provided by the subset of the experiment's data analyzed to date will also be shown, together with the extracted weak charge of the neutron.

Peptide receptor targeting in cancer: the somatostatin paradigm.

PubMed

Barbieri, Federica; Bajetto, Adriana; Pattarozzi, Alessandra; Gatti, Monica; Würth, Roberto; Thellung, Stefano; Corsaro, Alessandro; Villa, Valentina; Nizzari, Mario; Florio, Tullio

2013-01-01

Peptide receptors involved in pathophysiological processes represent promising therapeutic targets. Neuropeptide somatostatin (SST) is produced by specialized cells in a large number of human organs and tissues. SST primarily acts as inhibitor of endocrine and exocrine secretion via the activation of five G-protein-coupled receptors, named sst1-5, while in central nervous system, SST acts as a neurotransmitter/neuromodulator, regulating locomotory and cognitive functions. Critical points of SST/SST receptor biology, such as signaling pathways of individual receptor subtypes, homo- and heterodimerization, trafficking, and cross-talk with growth factor receptors, have been extensively studied, although functions associated with several pathological conditions, including cancer, are still not completely unraveled. Importantly, SST exerts antiproliferative and antiangiogenic effects on cancer cells in vitro, and on experimental tumors in vivo. Moreover, SST agonists are clinically effective as antitumor agents for pituitary adenomas and gastro-pancreatic neuroendocrine tumors. However, SST receptors being expressed by tumor cells of various tumor histotypes, their pharmacological use is potentially extendible to other cancer types, although to date no significant results have been obtained. In this paper the most recent findings on the expression and functional roles of SST and SST receptors in tumor cells are discussed.

A novel method for detecting neutralizing antibodies against therapeutic proteins by measuring gene expression.

PubMed

Yu, Yanbin; Piddington, Christopher; Fitzpatrick, Dan; Twomey, Brian; Xu, Ren; Swanson, Steven J; Jing, Shuqian

2006-10-20

The presence of neutralizing antibodies against protein therapeutics is a concern in the biomedical field. Such antibodies not only reduce the efficacy of protein therapeutics, but also impose potential dangers to the patients receiving them. To date, a small number of in vitro cell-based bioassays for detecting neutralizing antibodies against therapeutic proteins have been developed. Most of the existing assays, however, either involve the use of radioactive materials or have limited sensitivities and/or poor specificities. With advances in mRNA profiling and detection techniques, we have established a novel and non-radioactive bioassay system using branched DNA (bDNA) technology for detecting protein-therapeutic neutralizing antibodies in patient serum. Our assay measures the variations of target gene expression that reflect the biologic effect of the therapeutic agent and the capability of the antibodies, if present, to neutralize the therapeutics. Compared with most existing assays, the new assay is more sensitive and specific, and completely eliminates the use of radioactive materials. Application of the new assay system can be widely expanded if new target genes and responding cell lines for other therapeutics are identified or engineered.

Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates.

PubMed

Ntege, Edward H; Takashima, Eizo; Morita, Masayuki; Nagaoka, Hikaru; Ishino, Tomoko; Tsuboi, Takafumi

2017-08-01

An efficacious malaria vaccine is necessary to advance the current control measures towards malaria elimination. To-date, only RTS,S/AS01, a leading pre-erythrocytic stage vaccine completed phase 3 trials, but with an efficacy of 28-36% in children, and 18-26% in infants, that waned over time. Blood-stage malaria vaccines protect against disease, and are considered effective targets for the logical design of next generation vaccines to improve the RTS,S field efficacy. Therefore, novel blood-stage vaccine candidate discovery efforts are critical, albeit with several challenges including, high polymorphisms in vaccine antigens, poor understanding of targets of naturally protective immunity, and difficulties in the expression of high AT-rich plasmodial proteins. Areas covered: PubMed ( www.ncbi.nlm.nih.gov/pubmed ) was searched to review the progress and future prospects of malaria vaccine research and development. We focused on post-genome vaccine candidate discovery, malaria vaccine development, sequence diversity, pre-clinical and clinical trials. Expert commentary: Post-genome high-throughput technologies using wheat germ cell-free protein synthesis technology and immuno-profiling with sera from malaria patients with clearly defined outcomes are highlighted to overcome current challenges of malaria vaccine candidate discovery.

Identifying wide, cold planets within 8pc

NASA Astrophysics Data System (ADS)

Deacon, Niall; Kraus, Adam; Crossfield, Ian

2014-12-01

Direct imaging exoplanet studies have recently unveiled a previously-unexpected population of massive planets (up to 15 M_Jup) in wide orbits (>100AU). Although most of these discoveries have been around younger stars and have been of similar temperatures to field brown dwarfs, one object (WD 0806-661B), is the coldest planet known outside our solar system. We propose a survey of all stars and brown dwarfs within 8pc to identify massive planetary companions in the 150-1500AU separation range. We will 1) Measure the fraction of wide planetary mass companions to stars in the Solar neighbourhood. 2) Identify all planets within 8 parsecs with masses above 8 Jupiter masses in our chosen projected separation range with lower mass limits for closer and younger stars. 3) Identify approximately 8 planets, four of which will have temperatures below 300K making them ideal targets to study water clouds in cold atmospheres with both JWST and the next generation of ground-based extremely large telescopes. Our survey will be the most complete survey for wide planets to-date and will provide both a measurement of the wide planet population and a legacy of cold, well constrained targets for future observatories.

Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life.

PubMed

Lynnerup, Niels; Kjeldsen, Henrik; Heegaard, Steffen; Jacobsen, Christina; Heinemeier, Jan

2008-01-30

Lens crystallines are special proteins in the eye lens. Because the epithelial basement membrane (lens capsule) completely encloses the lens, desquamation of aging cells is impossible, and due to the complete absence of blood vessels or transport of metabolites in this area, there is no subsequent remodelling of these fibers, nor removal of degraded lens fibers. Human tissue ultimately derives its (14)C content from the atmospheric carbon dioxide. The (14)C content of the lens proteins thus reflects the atmospheric content of (14)C when the lens crystallines were formed. Precise radiocarbon dating is made possible by comparing the (14)C content of the lens crystallines to the so-called bomb pulse, i.e. a plot of the atmospheric (14)C content since the Second World War, when there was a significant increase due to nuclear-bomb testing. Since the change in concentration is significant even on a yearly basis this allows very accurate dating. Our results allow us to conclude that the crystalline formation in the lens nucleus almost entirely takes place around the time of birth, with a very small, and decreasing, continuous formation throughout life. The close relationship may be further expressed as a mathematical model, which takes into account the timing of the crystalline formation. Such a life-long permanence of human tissue has hitherto only been described for dental enamel. In confront to dental enamel it must be held in mind that the eye lens is a soft structure, subjected to almost continuous deformation, due to lens accommodation, yet its most important constituent, the lens crystalline, is never subject to turnover or remodelling once formed. The determination of the (14)C content of various tissues may be used to assess turnover rates and degree of substitution (for example for brain cell DNA). Potential targets may be nervous tissues in terms of senile or pre-senile degradation, as well as other highly specialised structures of the eyes. The precision with which the year of birth may be calculated points to forensic uses of this technique.

Radiocarbon Dating of the Human Eye Lens Crystallines Reveal Proteins without Carbon Turnover throughout Life

PubMed Central

Lynnerup, Niels; Kjeldsen, Henrik; Heegaard, Steffen; Jacobsen, Christina; Heinemeier, Jan

2008-01-01

Background Lens crystallines are special proteins in the eye lens. Because the epithelial basement membrane (lens capsule) completely encloses the lens, desquamation of aging cells is impossible, and due to the complete absence of blood vessels or transport of metabolites in this area, there is no subsequent remodelling of these fibers, nor removal of degraded lens fibers. Human tissue ultimately derives its 14C content from the atmospheric carbon dioxide. The 14C content of the lens proteins thus reflects the atmospheric content of 14C when the lens crystallines were formed. Precise radiocarbon dating is made possible by comparing the 14C content of the lens crystallines to the so-called bomb pulse, i.e. a plot of the atmospheric 14C content since the Second World War, when there was a significant increase due to nuclear-bomb testing. Since the change in concentration is significant even on a yearly basis this allows very accurate dating. Methodology/Principal Findings Our results allow us to conclude that the crystalline formation in the lens nucleus almost entirely takes place around the time of birth, with a very small, and decreasing, continuous formation throughout life. The close relationship may be further expressed as a mathematical model, which takes into account the timing of the crystalline formation. Conclusions/Significance Such a life-long permanence of human tissue has hitherto only been described for dental enamel. In confront to dental enamel it must be held in mind that the eye lens is a soft structure, subjected to almost continuous deformation, due to lens accommodation, yet its most important constituent, the lens crystalline, is never subject to turnover or remodelling once formed. The determination of the 14C content of various tissues may be used to assess turnover rates and degree of substitution (for example for brain cell DNA). Potential targets may be nervous tissues in terms of senile or pre-senile degradation, as well as other highly specialised structures of the eyes. The precision with which the year of birth may be calculated points to forensic uses of this technique. PMID:18231610

47 CFR 101.63 - Period of construction; certification of completion of construction.

Code of Federal Regulations, 2013 CFR

2013-10-01

... completion of construction. (a) Each Station, except in Multichannel Video Distribution and Data Service... this part must be in operation within 18 months from the initial date of grant. (b) For the 70 GHz, 80...

47 CFR 101.63 - Period of construction; certification of completion of construction.

Code of Federal Regulations, 2010 CFR

2010-10-01

... completion of construction. (a) Each Station, except in Multichannel Video Distribution and Data Service... this part must be in operation within 18 months from the initial date of grant. (b) For the 70 GHz, 80...

47 CFR 101.63 - Period of construction; certification of completion of construction.

Code of Federal Regulations, 2011 CFR

2011-10-01

... completion of construction. (a) Each Station, except in Multichannel Video Distribution and Data Service... this part must be in operation within 18 months from the initial date of grant. (b) For the 70 GHz, 80...

47 CFR 101.63 - Period of construction; certification of completion of construction.

Code of Federal Regulations, 2014 CFR

2014-10-01

... completion of construction. (a) Each Station, except in Multichannel Video Distribution and Data Service... this part must be in operation within 18 months from the initial date of grant. (b) For the 70 GHz, 80...

47 CFR 101.63 - Period of construction; certification of completion of construction.

Code of Federal Regulations, 2012 CFR

2012-10-01

... completion of construction. (a) Each Station, except in Multichannel Video Distribution and Data Service... this part must be in operation within 18 months from the initial date of grant. (b) For the 70 GHz, 80...

Energy Horizons: A Science and Technology Vision for Air Force Energy

DTIC Science & Technology

2012-04-01

target energy as a center of gravity. To date , more than 3,000 American Sol- diers and contractors have been killed or wounded protecting supply...failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE APR 2012 2. REPORT TYPE...3. DATES COVERED 00-00-2012 to 00-00-2012 4. TITLE AND SUBTITLE Energy Horizons: A Science and Technology Vision for Air Force Energy 5a

Air & Space Power Journal. Volume 26, Number 2, March-April 2012

DTIC Science & Technology

2012-03-01

subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE ...MAR 2012 2. REPORT TYPE 3. DATES COVERED 00-03-2012 to 00-04-2012 4. TITLE AND SUBTITLE Air & Space Power Journal. Volume 26, Number 2, March...Adversaries increasingly target energy as a center of gravity. To date , more than 3,000 American Sol- diers and contractors have been killed or

Health for All Targets: The Health Policy for Europe. Updated Edition, September 1991.

ERIC Educational Resources Information Center

World Health Organization, Copenhagen (Denmark). Regional Office for Europe.

In 1985, the 32 European Member States of the World Health Organization (WHO) Regional Office published 38 "targets of health for all." The new (1991) and revised targets incorporated in this book reflect changes that have taken place in the region since 1984 and provide an up-to-date understanding of the problems involved in target…

Endocannabinoids as a Target for the Treatment of Traumatic Brain Injury

DTIC Science & Technology

2012-11-01

DATES COVERED 4 October 2011- 3 October 2012 4. TITLE AND SUBTITLE Endocannabinoids as a Target for the Treatment of Traumatic Brain Injury 5a...interventions aimed at modulation of the endocannabinoid (EC) system targeting degradation of 20arachidonoyl glycerlol (2- AG) and N-arachidonoyl...percussion, traumatic brain injury, blood brain barrier, neuroinflammination, neurological dysfunction, endocannabinoids . 16. SECURITY CLASSIFICATION

Complete Columbian mammoth mitogenome suggests interbreeding with woolly mammoths

PubMed Central

2011-01-01

Background Late Pleistocene North America hosted at least two divergent and ecologically distinct species of mammoth: the periglacial woolly mammoth (Mammuthus primigenius) and the subglacial Columbian mammoth (Mammuthus columbi). To date, mammoth genetic research has been entirely restricted to woolly mammoths, rendering their genetic evolution difficult to contextualize within broader Pleistocene paleoecology and biogeography. Here, we take an interspecific approach to clarifying mammoth phylogeny by targeting Columbian mammoth remains for mitogenomic sequencing. Results We sequenced the first complete mitochondrial genome of a classic Columbian mammoth, as well as the first complete mitochondrial genome of a North American woolly mammoth. Somewhat contrary to conventional paleontological models, which posit that the two species were highly divergent, the M. columbi mitogenome we obtained falls securely within a subclade of endemic North American M. primigenius. Conclusions Though limited, our data suggest that the two species interbred at some point in their evolutionary histories. One potential explanation is that woolly mammoth haplotypes entered Columbian mammoth populations via introgression at subglacial ecotones, a scenario with compelling parallels in extant elephants and consistent with certain regional paleontological observations. This highlights the need for multi-genomic data to sufficiently characterize mammoth evolutionary history. Our results demonstrate that the use of next-generation sequencing technologies holds promise in obtaining such data, even from non-cave, non-permafrost Pleistocene depositional contexts. PMID:21627792

Randomized Trial of Reducing Ambulatory Malpractice and Safety Risk: Results of the Massachusetts PROMISES Project.

PubMed

Schiff, Gordon D; Reyes Nieva, Harry; Griswold, Paula; Leydon, Nicholas; Ling, Judy; Federico, Frank; Keohane, Carol; Ellis, Bonnie R; Foskett, Cathy; Orav, E John; Yoon, Catherine; Goldmann, Don; Weissman, Joel S; Bates, David W; Biondolillo, Madeleine; Singer, Sara J

2017-08-01

Evaluate application of quality improvement approaches to key ambulatory malpractice risk and safety areas. In total, 25 small-to-medium-sized primary care practices (16 intervention; 9 control) in Massachusetts. Controlled trial of a 15-month intervention including exposure to a learning network, webinars, face-to-face meetings, and coaching by improvement advisors targeting "3+1" high-risk domains: test result, referral, and medication management plus culture/communication issues evaluated by survey and chart review tools. Chart reviews conducted at baseline and postintervention for intervention sites. Staff and patient survey data collected at baseline and postintervention for intervention and control sites. Chart reviews demonstrated significant improvements in documentation of abnormal results, patient notification, documentation of an action or treatment plan, and evidence of a completed plan (all P<0.001). Mean days between laboratory test date and evidence of completed action/treatment plan decreased by 19.4 days (P<0.001). Staff surveys showed modest but nonsignificant improvement for intervention practices relative to controls overall and for the 3 high-risk domains that were the focus of PROMISES. A consortium of stakeholders, quality improvement tools, coaches, and learning network decreased selected ambulatory safety risks often seen in malpractice claims.

A web-based screening and accrual strategy for a cancer prevention clinical trial in healthy smokers.

PubMed

Mohebati, Arash; Knutson, Allison; Zhou, Xi Kathy; Smith, Judith J; Brown, Powel H; Dannenberg, Andrew J; Szabo, Eva

2012-09-01

Screening and recruitment of qualified subjects for clinical trials is an essential component of translational research, and it can be quite challenging if the most efficient recruitment method is not utilized. In this report, we describe a successful web-based screening and accrual method used in a randomized prospective chemoprevention clinical trial with urinary biomarker endpoints. The targeted study population was a group of at-risk healthy current smokers with no evidence of lung disease. Craigslist was used as the sole recruitment modality for this study. All interested subjects were directed to a pre-screening website, in which subject questionnaire responses were linked to the study coordinator's secure e-mail account. Of the 429 initial inquiries, 189 individuals were initially eligible based on the questionnaire response. One hundred twenty-two people were telephone-screened, of whom 98 subjects were consented, 84 were randomized and 77 subjects completed the study successfully. Utilizing this single web-based advertising strategy, accrual for the trial was completed 7 months prior to the projected date. Craigslist is a cost effective and efficient web-based resource that can be utilized in accruing subjects to some chemoprevention trials. Published by Elsevier Inc.

A web-based screening and accrual strategy for a cancer prevention clinical trial in healthy smokers

PubMed Central

Mohebati, Arash; Knutson, Allison; Zhou, Xi Kathy; Smith, Judith J.; Brown, Powel H.; Dannenberg, Andrew J.; Szabo, Eva

2012-01-01

Screening and recruitment of qualified subjects for clinical trials is an essential component of translational research, and it can be quite challenging if the most efficient recruitment method is not utilized. In this report, we describe a successful web-based screening and accrual method used in a randomized prospective chemoprevention clinical trial with urinary biomarker endpoints. The targeted study population was a group of at-risk healthy current smokers with no evidence of lung disease. Craigslist was used as the sole recruitment modality for this study. All interested subjects were directed to a pre-screening website, in which subject questionnaire responses were linked to the study coordinator's secure e-mail account. Of the 429 initial inquiries, 189 individuals were initially eligible based on the questionnaire response. One hundred twenty-two people were telephone-screened, of whom 98 subjects were consented, 84 were randomized and 77 subjects completed the study successfully. Utilizing this single web-based advertising strategy, accrual for the trial was completed 7 months prior to the projected date. Craigslist is a cost effective and efficient web-based resource that can be utilized in accruing subjects to some chemoprevention trials. PMID:22771576

PBO Facility Construction: Basin and Range and Rocky Mountain Regions Status

NASA Astrophysics Data System (ADS)

Friesen, B.; Jenkins, F.; Kasmer, D.; Feaux, K.

2007-12-01

The Plate Boundary Observatory (PBO), part of the larger NSF-funded EarthScope project, will study the three- dimensional strain field resulting from active plate boundary deformation across the western United States. PBO is a large construction project involving the reconnaissance, permitting, installation, documentation, and maintenance of 875 permanent GPS stations in five years. 163 of these stations lie within the Basin and Range and Rocky Mountain Regions consisting of the states of Montana, Idaho, Nevada, Utah, Wyoming, Colorado, New Mexico, and Arizona. During the fourth year of the project, the Basin and Range and Rocky Mountain regions of PBO completed reconnaissance and nearly all permitting activities, and maintained a fast pace of station installations. The fall of 2006 and spring of 2007 were devoted to the construction of a large push of 50 stations, most located on Bureau of Land Management controlled public lands in Nevada. This transect is located along Highway 50 and will profile the extension of the Basin and Range province. The Yellowstone area, including surrounding National Parks and Forests was the target of summer 2007, during which time 10 remote stations with difficult logistics were installed. To date, construction is complete for 135 of 163 GPS stations.

Climate Change and Phenology: Empoasca fabae (Hemiptera: Cicadellidae) Migration and Severity of Impact

PubMed Central

Lamp, William O.

2015-01-01

Climate change can benefit individual species, but when pest species are enhanced by warmer temperatures agricultural productivity may be placed at greater risk. We analyzed the effects of temperature anomaly on arrival date and infestation severity of potato leafhopper, Empoasca fabae Harris, a classic new world long distance migrant, and a significant pest in several agricultural crops. We compiled E. fabae arrival dates and infestation severity data at different states in USA from existing literature reviews and agricultural extension records from 1951–2012, and examined the influence of temperature anomalies at each target state or overwintering range on the date of arrival and severity of infestation. Average E. fabae arrival date at different states reveal a clear trend along the south-north axis, with earliest arrival closest to the overwintering range. E. fabae arrival has advanced by 10 days over the last 62 years. E. fabae arrived earlier in warmer years in relation to each target state level temperature anomaly (3.0 days / °C increase in temperature anomaly). Increased temperature had a significant and positive effect on the severity of infestation, and arrival date had a marginal negative effect on severity. These relationships suggest that continued warming could advance the time of E. fabae colonization and increase their impact on affected crops. PMID:25970705

Development and evaluation of a mobile intervention for heavy drinking and smoking among college students.

PubMed

Witkiewitz, Katie; Desai, Sruti A; Bowen, Sarah; Leigh, Barbara C; Kirouac, Megan; Larimer, Mary E

2014-09-01

Nearly all college student smokers also drink alcohol, and smoking and heavy episodic drinking (HED) commonly co-occur. However, few studies have examined the factors that concurrently influence smoking and HED among college students and, to date, no interventions have been developed that target both HED and smoking in this population. The objective of the current study was to develop and evaluate a mobile feedback intervention that targets HED and smoking. Participants (N = 94) were non-treatment-seeking college students (M(age) = 20.5 years, SD = 1.7) who engaged in at least a single HED episode in the past 2 weeks and reported concurrent smoking and drinking at least once a week. Participants were randomized to receive either the mobile intervention for 14 days, complete mobile assessments (without intervention) for 14 days, or complete minimal assessments (without intervention or mobile assessments). At a 1-month follow-up, compared with the minimal assessment condition, we observed significant reductions in the number of cigarettes per smoking day in both the mobile intervention (d = 0.55) and mobile assessment (d = 0.45) conditions. Among those randomized to the mobile intervention, receiving more modules of the intervention was significantly associated with a lower likelihood of any drinking during the 14-day assessment period and significant reductions in smoking at 1-month follow-up. The mobile intervention did not result in significant reductions in HED or concurrent smoking and drinking. Future research should continue to examine ways of using technology and the real-time environment to improve interventions for HED and smoking.

Sexual relationship power as a mediator between dating violence and sexually transmitted infections among college women.

PubMed

Buelna, Christina; Ulloa, Emilio C; Ulibarri, Monica D

2009-08-01

This study examined relationship power as a possible mediator of the relationship between dating violence and sexually transmitted infections (STIs). The proposed mediation model was based on the theory of gender and power as well as previous research on intimate partner violence and STI risk. Survey results from a sample of 290 single, undergraduate women indicated that 85% experienced at least one form of dating violence victimization in the past year, 5.9% tested positive for an STI, and 5.2% received treatment for an STI. Results revealed that women with lower levels of sexual relationship power had higher rates of dating violence victimization and STIs; also, sexual relationship power partially mediated the relationship between dating violence victimization and STIs. Future dating violence and STI-prevention interventions targeting young women may want to use an empowerment approach to decrease their likelihood of dating violence victimization and STI risk.

The Associations Between Substance Use, Sexual Behaviors, Bullying, Deviant Behaviors, Health, and Cyber Dating Abuse Perpetration.

PubMed

Van Ouytsel, Joris; Torres, Elizabeth; Choi, Hye Jeong; Ponnet, Koen; Walrave, Michel; Temple, Jeff R

2017-04-01

Dating violence is an important public health concern and is considered to be a form of school violence. While digital technologies have enabled perpetrators of dating violence to target their victims online (cyber dating abuse), little is known about how this form of perpetration relates to specific adolescent risk behaviors. This brief research report focuses on the associations between substance use, sexual behaviors, deviant behaviors, self-reported health, and cyber dating abuse perpetration. Participants included 705 ethnically diverse adolescents ( n = 408; 57.9% female) in Southeast Texas. Having had sexual intercourse or using alcohol or drugs before having sex was significantly linked with cyber dating abuse perpetration, as was poor physical health, and substance use. Consistent with limited research, we found a link between cyber dating abuse and engagement in bullying behaviors. The discussion section includes suggestions for school nurse practice and further research.

(De)coupled zircon metamictization, radiation damage, and He diffusivity

NASA Astrophysics Data System (ADS)

Ault, A. K.; Guenthner, W.; Reiners, P. W.; Moser, A. C.; Miller, G. H.; Refsnider, K. A.

2017-12-01

We develop and apply a new protocol for targeting crystals for the zircon (U-Th)/He (He) thermochronometry to maximize effective U (eU) and corresponding closure temperature variability to develop zircon He date-eU correlations observed in some datasets. Our approach exploits visual proxies for radiation damage accumulation (metamictization) during zircon selection. We show that by purposefully targeting a spectrum of zircon textures from pristine to metamict grains, it is possible to generate broad eU variation in suites of zircon from a single sample and zircon He date-eU-metamictization trends that can be exploited to resolve increasingly complex thermal histories. We present plane light photographs, eU concentration, and zircon He results from 59 individual zircons from nine crystalline rock samples. Six of the nine samples come from exposed Proterozoic granitoids on SE Baffin Island, Canada; Boulder Creek, CO; Sandia Mountains, NM; and Mecca Hills, CA. We report data from three Archean Baffin samples to compare with the Proterozoic Baffin sample date-eU-metamictization trend. In each Proterozoic sample, target zircons display a spectrum of metamictization from pristine, transparent crystals to purple-brown, translucent grains. Progressive loss of transparency and increase in discoloration consistently corresponds to an increase in eU in all samples. Individual zircon eU varies from 89-1885 ppm and, within each sample, the total eU spread is 538 ppm to 1374 ppm. For any given eU value, the Archean zircon appear comparatively more metamict than the Proterozoic Baffin grains and samples collectively define a 1681 ppm range in eU, with more restrictive intrasample eU spreads (199-1120 ppm). Proterozoic samples from Baffin, Sandia, and Front Range yield negative zircon He date-eU correlations with intrasample date ranges of 90-783 Ma. Increasing eU and younger dates correspond with increasing metamictization. In contrast, all three Proterozoic Mecca Hills samples yield uniform 25 Ma zircon He dates over 1800 ppm eU. We apply simple thermal history models that account for the coevolution of zircon radiation damage and He-diffusivity to demonstrate that visible zircon metamictization and He diffusivity can be either coupled or decoupled depending on a sample's thermal history.

The process of adapting a universal dating abuse prevention program to adolescents exposed to domestic violence.

PubMed

Foshee, Vangie A; Dixon, Kimberly S; Ennett, Susan T; Moracco, Kathryn E; Bowling, J Michael; Chang, Ling-Yin; Moss, Jennifer L

2015-07-01

Adolescents exposed to domestic violence are at increased risk of dating abuse, yet no evaluated dating abuse prevention programs have been designed specifically for this high-risk population. This article describes the process of adapting Families for Safe Dates (FSD), an evidenced-based universal dating abuse prevention program, to this high-risk population, including conducting 12 focus groups and 107 interviews with the target audience. FSD includes six booklets of dating abuse prevention information, and activities for parents and adolescents to do together at home. We adapted FSD for mothers who were victims of domestic violence, but who no longer lived with the abuser, to do with their adolescents who had been exposed to the violence. Through the adaptation process, we learned that families liked the program structure and valued being offered the program and that some of our initial assumptions about this population were incorrect. We identified practices and beliefs of mother victims and attributes of these adolescents that might increase their risk of dating abuse that we had not previously considered. In addition, we learned that some of the content of the original program generated negative family interactions for some. The findings demonstrate the utility of using a careful process to adapt evidence-based interventions (EBIs) to cultural sub-groups, particularly the importance of obtaining feedback on the program from the target audience. Others can follow this process to adapt EBIs to groups other than the ones for which the original EBI was designed. © The Author(s) 2014.

Sphingolipids from the human fungal pathogen Aspergillus fumigatus.

PubMed

Fontaine, Thierry

2017-10-01

Sphingolipids (SPLs) are key components of the plasma membrane in yeast and filamentous fungi. These molecules are involved in a number of cellular processes, and particularly, SGLs are essential components of the highly polarized fungal growth where they are required for the formation of the polarisome organization at the hyphal apex. Aspergillus fumigatus, a human fungal pathogen, produce SGLs that are discriminated into neutral cerebrosides, glycosylinositolphosphoceramides (GIPCs) and glycosylphosphatidylinositol (GPI) anchors. In addition to complex hydrophilic head groups of GIPCs, A. fumigatus is, to date, the sole fungus that produces a GPI-anchored polysaccharide. These SPLs follow three different biosynthetic pathways. Genetics blockage leading to the inhibition of any SPL biosynthesis or to the alteration of the structure of SPL induces growth and virulence defects. The complete lipid moiety of SPLs is essential for the lipid microdomain organization and their biosynthetic pathways are potential antifungal targets but remains understudied. Copyright © 2017. Published by Elsevier B.V.

Global priorities for conserving the evolutionary history of sharks, rays and chimaeras.

PubMed

Stein, R William; Mull, Christopher G; Kuhn, Tyler S; Aschliman, Neil C; Davidson, Lindsay N K; Joy, Jeffrey B; Smith, Gordon J; Dulvy, Nicholas K; Mooers, Arne O

2018-02-01

In an era of accelerated biodiversity loss and limited conservation resources, systematic prioritization of species and places is essential. In terrestrial vertebrates, evolutionary distinctness has been used to identify species and locations that embody the greatest share of evolutionary history. We estimate evolutionary distinctness for a large marine vertebrate radiation on a dated taxon-complete tree for all 1,192 chondrichthyan fishes (sharks, rays and chimaeras) by augmenting a new 610-species molecular phylogeny using taxonomic constraints. Chondrichthyans are by far the most evolutionarily distinct of all major radiations of jawed vertebrates-the average species embodies 26 million years of unique evolutionary history. With this metric, we identify 21 countries with the highest richness, endemism and evolutionary distinctness of threatened species as targets for conservation prioritization. On average, threatened chondrichthyans are more evolutionarily distinct-further motivating improved conservation, fisheries management and trade regulation to avoid significant pruning of the chondrichthyan tree of life.

Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

PubMed

Kusuzaki, Katsuyuki; Matsubara, Takao; Murata, Hiroaki; Logozzi, Mariantonia; Iessi, Elisabetta; Di Raimo, Rossella; Carta, Fabrizio; Supuran, Claudiu T; Fais, Stefano

2017-12-01

Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotoxic activity against tumour cells. However, to date their clinical use is limited by the side effects elicited by systemic administration. Extracellular vesicles are endogenous nanosized-carriers that have been recently introduced as a natural delivery system for therapeutic molecules. We have recently shown the ability of human exosomes to deliver photodynamic molecules. Therefore, this review focussed on extracellular vesicles as a novel strategy for the delivery of photodynamic molecules at cancer sites. This completely new approach may enhance the delivery and decrease the toxicity of photodynamic molecules, therefore, represent the future for photodynamic therapy for cancer treatment.

Quantifying the decisional satisfaction to accept or reject the Human Papillomavirus (HPV) vaccine: a preference for cervical cancer prevention.

PubMed

Harper, Diane M; Irons, Billy B; Alexander, Natalie M; Comes, Johanna C; Smith, Melissa S; Heutinck, Melinda A; Handley, Sandra M; Ahern, Debra A

2014-01-01

Only a portion of the US population is willing to consider HPV vaccination to date. The primary aim of this study is to determine the decisional satisfaction associated with HPV vaccination. This is a prospective survey conducted at an urban college where women 18-26 years old completed a decisional satisfaction survey about their HPV vaccine experience. Regardless of the decision to accept or reject HPV vaccination, the decisional satisfaction was very high (mean 5-item score = 21.2 (SD 3.8)). Women without HPV vaccination were decisionally neutral significantly more often than those already vaccinated; 22% were decisionally neutral for the option to accept HPV vaccination at that visit. Cervical cancer prevention was preferred significantly more often than genital wart prevention in all analyses. Targeting those who are decisionally neutral about HPV vaccination may result in a higher uptake of HPV vaccination.

First measurement of the muon neutrino charged current quasielastic double differential cross section

NASA Astrophysics Data System (ADS)

Aguilar-Arevalo, A. A.; Anderson, C. E.; Bazarko, A. O.; Brice, S. J.; Brown, B. C.; Bugel, L.; Cao, J.; Coney, L.; Conrad, J. M.; Cox, D. C.; Curioni, A.; Djurcic, Z.; Finley, D. A.; Fleming, B. T.; Ford, R.; Garcia, F. G.; Garvey, G. T.; Grange, J.; Green, C.; Green, J. A.; Hart, T. L.; Hawker, E.; Imlay, R.; Johnson, R. A.; Karagiorgi, G.; Kasper, P.; Katori, T.; Kobilarcik, T.; Kourbanis, I.; Koutsoliotas, S.; Laird, E. M.; Linden, S. K.; Link, J. M.; Liu, Y.; Liu, Y.; Louis, W. C.; Mahn, K. B. M.; Marsh, W.; Mauger, C.; McGary, V. T.; McGregor, G.; Metcalf, W.; Meyers, P. D.; Mills, F.; Mills, G. B.; Monroe, J.; Moore, C. D.; Mousseau, J.; Nelson, R. H.; Nienaber, P.; Nowak, J. A.; Osmanov, B.; Ouedraogo, S.; Patterson, R. B.; Pavlovic, Z.; Perevalov, D.; Polly, C. C.; Prebys, E.; Raaf, J. L.; Ray, H.; Roe, B. P.; Russell, A. D.; Sandberg, V.; Schirato, R.; Schmitz, D.; Shaevitz, M. H.; Shoemaker, F. C.; Smith, D.; Soderberg, M.; Sorel, M.; Spentzouris, P.; Spitz, J.; Stancu, I.; Stefanski, R. J.; Sung, M.; Tanaka, H. A.; Tayloe, R.; Tzanov, M.; van de Water, R. G.; Wascko, M. O.; White, D. H.; Wilking, M. J.; Yang, H. J.; Zeller, G. P.; Zimmerman, E. D.; MiniBooNE Collaboration

2010-05-01

A high-statistics sample of charged-current muon neutrino scattering events collected with the MiniBooNE experiment is analyzed to extract the first measurement of the double differential cross section ((d2σ)/(dTμdcos⁡θμ)) for charged-current quasielastic (CCQE) scattering on carbon. This result features minimal model dependence and provides the most complete information on this process to date. With the assumption of CCQE scattering, the absolute cross section as a function of neutrino energy (σ[Eν]) and the single differential cross section ((dσ)/(dQ2)) are extracted to facilitate comparison with previous measurements. These quantities may be used to characterize an effective axial-vector form factor of the nucleon and to improve the modeling of low-energy neutrino interactions on nuclear targets. The results are relevant for experiments searching for neutrino oscillations.

Production Facility Prototype Blower 1000 Hour Test Results II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wass, Alexander Joseph; Woloshun, Keith Albert; Dale, Gregory E.

Long duration tests of the Aerzen GM 12.4 roots style blower in a closed loop configuration provides valuable data and lessons learned for long-term operation at the Mo-99 production facility. The blower was operated in a closed loop configuration with the flow conditions anticipated in plant operation with a Mo-100 target inline. The additional thermal energy generated from beam heating of the Mo-100 disks were not included in these tests. Five 1000 hour tests have been completed since the first test was performed in January of 2016. All five 1000 hour tests have proven successful in exposing preventable issues relatedmore » to oil and helium leaks. All blower tests to this date have resulted in stable blower performance and consistency. A summary of the results for each test, including a review of the first and second tests, are included in this report.« less

KSC-08pd3255

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lifts the Multi-Use Lightweight Equipment, or MULE, carrier from the payload canister. It will be moved to a stand in the PHSF. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

KSC-08pd3254

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, a crane lifts the Multi-Use Lightweight Equipment, or MULE, carrier from the payload canister. It will be moved to a stand in the PHSF. The carrier contains hardware for the STS-125 Hubble Space Telescope servicing mission that has been returned to the PHSF to await a new launch date for the mission. Atlantis' targeted launch on Oct. 14 was delayed when a system that transfers science data from the orbiting observatory to Earth malfunctioned on Sept. 27. The new target launch date is under review. Photo credit: NASA/Kim Shiflett

Developmental Associations Between Adolescent Alcohol Use and Dating Aggression

PubMed Central

Reyes, H. Luz McNaughton; Foshee, Vangie A.; Bauer, Daniel J.; Ennett, Susan T.

2012-01-01

While numerous studies have established a link between alcohol use and partner violence in adulthood, little research has examined this relation during adolescence. The current study used multivariate growth models to examine relations between alcohol use and dating aggression across grades 8 through 12 controlling for shared risk factors (common causes) that predict both behaviors. Associations between trajectories of alcohol use and dating aggression were reduced substantially when common causes were controlled. Concurrent associations between the two behaviors were significant across nearly all grades but no evidence was found for prospective connections from prior alcohol use to subsequent dating aggression or vice versa. Findings suggest that prevention efforts should target common causes of alcohol use and dating aggression. PMID:23589667

45 CFR 96.49 - Due date for receipt of all information required for completion of tribal applications for the...

Code of Federal Regulations, 2010 CFR

2010-10-01

... for completion of tribal applications for the low-income home energy assistance block grants. 96.49 Section 96.49 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS... required for completion of tribal applications for the low-income home energy assistance block grants...

76 FR 28211 - Proposed Information Collection; Comment Request; Survey of Housing Starts, Sales, and Completions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-16

... Housing Starts, Sales, and Completions AGENCY: U.S. Census Bureau, Commerce. ACTION: Notice. SUMMARY: The... and Budget (OMB) clearance of the Survey of Housing Starts, Sales and Completions, also known as the... system, etc.), and if applicable, date of sale, sales price, and type of financing. The SOC provides...

FNAS CRRES program completion

NASA Technical Reports Server (NTRS)

Miller, George P.

1992-01-01

An agenda and the list of attendees at the Combined Release and Radiation Effects Satellite (CRRES) IWG meeting, held on 14-15 Dec. 1992, are presented. Short summaries of the work that has been completed to date, in support of the contract, are presented.

Aerial view of entire LTA base after completion of both ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Aerial view of entire LTA base after completion of both LTA ship hangars. Date unknown but probably circa 1945. - Marine Corps Air Station Tustin, Northern Lighter Than Air Ship Hangar, Meffett Avenue & Maxfield Street, Tustin, Orange County, CA

Gender Role Attitudes and Male Adolescent Dating Violence Perpetration: Normative Beliefs as Moderators.

PubMed

Reyes, H Luz McNaughton; Foshee, Vangie A; Niolon, Phyllis Holditch; Reidy, Dennis E; Hall, Jeffrey E

2016-02-01

Commonly used dating violence prevention programs assume that promotion of more egalitarian gender role attitudes will prevent dating violence perpetration. Empirical research examining this assumption, however, is limited and inconsistent. The current study examined the longitudinal association between gender role attitudes and physical dating violence perpetration among adolescent boys (n = 577; 14 % Black, 5 % other race/ethnicity) and examined whether injunctive (i.e., acceptance of dating violence) and descriptive (i.e., beliefs about dating violence prevalence) normative beliefs moderated the association. As expected, the findings suggest that traditional gender role attitudes at T1 were associated with increased risk for dating violence perpetration 18 months later (T2) among boys who reported high, but not low, acceptance of dating violence (injunctive normative beliefs) at T1. Descriptive norms did not moderate the effect of gender role attitudes on dating violence perpetration. The results suggest that injunctive norms and gender role attitudes work synergistically to increase risk for dating violence perpetration among boys; as such, simultaneously targeting both of these constructs may be an effective prevention approach.

Gender Role Attitudes and Male Adolescent Dating Violence Perpetration: Normative Beliefs as Moderators

PubMed Central

Reyes, H. Luz McNaughton; Foshee, Vangie A.; Niolon, Phyllis Holditch; Reidy, Dennis E.; Hall, Jeffrey E.

2015-01-01

Commonly used dating violence prevention programs assume that promotion of more egalitarian gender role attitudes will prevent dating violence perpetration. Empirical research examining this assumption, however, is limited and inconsistent. The current study examined the longitudinal association between gender role attitudes and physical dating violence perpetration among adolescent boys (n=577; 14% Black, 5% other race/ethnicity) and examined whether injunctive (i.e., acceptance of dating violence) and descriptive (i.e., beliefs about dating violence prevalence) normative beliefs moderated the association. As expected, the findings suggest that traditional gender role attitudes at T1 were associated with increased risk for dating violence perpetration 18 months later (T2) among boys who reported high, but not low, acceptance of dating violence (injunctive normative beliefs) at T1. Descriptive norms did not moderate the effect of gender role attitudes on dating violence perpetration. The results suggest that injunctive norms and gender role attitudes work synergistically to increase risk for dating violence perpetration among boys; as such, simultaneously targeting both of these constructs may be an effective prevention approach. PMID:25831994

26 CFR 1.368-3 - Records to be kept and information to be filed with returns.

Code of Federal Regulations, 2010 CFR

2010-04-01

... such parties; (2) The date of the reorganization; (3) The aggregate fair market value and basis, determined immediately before the exchange, of the assets, stock or securities of the target corporation... all of the parties to the reorganization; (2) The date of the reorganization; and (3) The fair market...

Microprojectile Bombardment Transformation of Date Palm Using the Insecticidal Cholesterol Oxidase (ChoA) Gene.

PubMed

Allam, Mai A; Saker, Mahmoud M

2017-01-01

The overall objective of this work is to optimize the transformation system for date palm as a first step toward production of date palm clones resistant to noxious pests. A construct harboring the cholesterol oxidase (ChoA) gene, which renders plant resistance against insect attack, is introduced into embryogenic date palm callus using the PDS-1000/He particle bombardment system. The process involves the establishment of embryogenic callus cultures as well as immature embryo-derived microcalli that are used as target tissues for shooting and optimization of transformation conditions. This chapter in addition explains molecular and histochemical assays conducted to confirm gene integration and expression.

Randomized clinical trials in orthodontics are rarely registered a priori and often published late or not at all.

PubMed

Papageorgiou, Spyridon N; Antonoglou, Georgios N; Sándor, George K; Eliades, Theodore

2017-01-01

A priori registration of randomized clinical trials is crucial to the transparency and credibility of their findings. Aim of this study was to assess the frequency with which registered and completed randomized trials in orthodontics are published. We searched ClinicalTrials.gov and ISRCTN for registered randomized clinical trials in orthodontics that had been completed up to January 2017 and judged the publication status and date of registered trials using a systematic protocol. Statistical analysis included descriptive statistics, chi-square or Fisher exact tests, and Kaplan-Meier survival estimates. From the 266 orthodontic trials registered up to January 2017, 80 trials had been completed and included in the present study. Among these 80 included trials, the majority (76%) were registered retrospectively, while only 33 (41%) were published at the time. The median time from completion to publication was 20.1 months (interquartile range: 9.1 to 31.6 months), while survival analysis indicated that less than 10% of the trials were published after 5 years from their completion. Finally, 22 (28%) of completed trials remain unpublished even after 5 years from their completion. Publication rates of registered randomized trials in orthodontics remained low, even 5 years after their completion date.

Randomized clinical trials in orthodontics are rarely registered a priori and often published late or not at all

PubMed Central

Antonoglou, Georgios N.; Sándor, George K.; Eliades, Theodore

2017-01-01

A priori registration of randomized clinical trials is crucial to the transparency and credibility of their findings. Aim of this study was to assess the frequency with which registered and completed randomized trials in orthodontics are published. We searched ClinicalTrials.gov and ISRCTN for registered randomized clinical trials in orthodontics that had been completed up to January 2017 and judged the publication status and date of registered trials using a systematic protocol. Statistical analysis included descriptive statistics, chi-square or Fisher exact tests, and Kaplan-Meier survival estimates. From the 266 orthodontic trials registered up to January 2017, 80 trials had been completed and included in the present study. Among these 80 included trials, the majority (76%) were registered retrospectively, while only 33 (41%) were published at the time. The median time from completion to publication was 20.1 months (interquartile range: 9.1 to 31.6 months), while survival analysis indicated that less than 10% of the trials were published after 5 years from their completion. Finally, 22 (28%) of completed trials remain unpublished even after 5 years from their completion. Publication rates of registered randomized trials in orthodontics remained low, even 5 years after their completion date. PMID:28777820

36 CFR 223.47 - Date of completion of permanent road construction.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL PRODUCTS Timber Sale Contracts Contract Conditions and Provisions § 223.47 Date of... obligations as set forth in the Notice of Sale shall be incorporated into the timber sale contract. (b) This...

40 CFR 60.2740 - What records must I keep?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (b)(1) through (6) of this section: (1) The CISWI unit charge dates, times, weights, and hourly... showing the names of the CISWI operators who have completed the operator training requirements under § 60... under § 60.2650 or § 60.2655. Records must include documentation of training, the dates of the initial...

13 CFR 120.465 - Civil penalty for late submission of required reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

13 CFR 120.465 - Civil penalty for late submission of required reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

13 CFR 120.465 - Civil penalty for late submission of required reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

13 CFR 120.465 - Civil penalty for late submission of required reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

40 CFR 63.454 - Recordkeeping requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... defect or leak is not repaired within 15 days after discovery; (9) The expected date of successful repair of the defect or leak if the repair is not completed within 15 days; (10) The date of successful... 15 minutes. (f) The owner or operator of an open biological treatment system complying with § 63.453...

40 CFR 63.454 - Recordkeeping requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... defect or leak is not repaired within 15 days after discovery; (9) The expected date of successful repair of the defect or leak if the repair is not completed within 15 days; (10) The date of successful... 15 minutes. (f) The owner or operator of an open biological treatment system complying with § 63.453...

The Impact of External Resources on Conflict and Violence in Dating Relationships.

ERIC Educational Resources Information Center

Johnson, Katherine I.

Eighty-six college-aged, heterosexual couples completed questionnaires and subsequently were interviewed separately in order to test the hypothesis derived from social exchange theory that higher levels of conflict or violence will be reported in dating relationships in which one partner has fewer external resources. External resources were…

26 CFR 1.332-2 - Requirements for nonrecognition of gain or loss.

Code of Federal Regulations, 2011 CFR

2011-04-01

... liquidation may be completed prior to the actual dissolution of the liquidating corporation. However, legal dissolution of the corporation is not required. Nor will the mere retention of a nominal amount of assets for.... On that date, and thereafter until the date of dissolution of the M Corporation, the O Corporation...

Adolescents' Anxiety in Dating Situations: The Potential Role of Friends and Romantic Partners

ERIC Educational Resources Information Center

La Greca, Annette M.; Mackey, Eleanor Race

2007-01-01

This study examined adolescents' interpersonal functioning, including the qualities of their closest friendships and romantic relationships, as predictors of dating/heterosocial anxiety. An ethnically diverse sample of 781 adolescents (57% girls; ages 15-19 years) completed measures that assessed the number and type of close friends, the presence…

7 CFR 774.18 - Interest rate, terms and security requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS EMERGENCY LOAN FOR SEED PRODUCERS PROGRAM § 774.18 Interest rate... percent for 36 months or until the date of settlement of, completion of, or final distribution of assets... bankruptcy claim or 36 months from the date of the note. (2) However, any principal remaining thereafter will...

7 CFR 774.18 - Interest rate, terms and security requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS EMERGENCY LOAN FOR SEED PRODUCERS PROGRAM § 774.18 Interest rate... percent for 36 months or until the date of settlement of, completion of, or final distribution of assets... bankruptcy claim or 36 months from the date of the note. (2) However, any principal remaining thereafter will...

7 CFR 774.18 - Interest rate, terms and security requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS EMERGENCY LOAN FOR SEED PRODUCERS PROGRAM § 774.18 Interest rate... percent for 36 months or until the date of settlement of, completion of, or final distribution of assets... bankruptcy claim or 36 months from the date of the note. (2) However, any principal remaining thereafter will...

7 CFR 774.18 - Interest rate, terms and security requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS EMERGENCY LOAN FOR SEED PRODUCERS PROGRAM § 774.18 Interest rate... percent for 36 months or until the date of settlement of, completion of, or final distribution of assets... bankruptcy claim or 36 months from the date of the note. (2) However, any principal remaining thereafter will...

Individual and Situational Influences on Men's Responses to Dating and Social Situations

ERIC Educational Resources Information Center

Hoyt, Tim; Yeater, Elizabeth A.

2011-01-01

This study employed multilevel modeling to evaluate individual and situational influences on men's responses to hypothetical dating and social situations. Three hundred and fifty college men completed measures assessing their propensity for sexual aggression and provided written responses to 10 written vignettes, each of which was followed by four…

33 CFR 127.317 - Declaration of inspection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... handling LNG; (2) The date and time that transfer operations begin; (3) A list of the requirements in § 127... operations and the date and time of signing, indicating that he or she is ready to begin transfer operations... inspection. (a) After the preliminary transfer inspection under § 127.315 has been satisfactorily completed...

33 CFR 127.317 - Declaration of inspection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... handling LNG; (2) The date and time that transfer operations begin; (3) A list of the requirements in § 127... operations and the date and time of signing, indicating that he or she is ready to begin transfer operations... inspection. (a) After the preliminary transfer inspection under § 127.315 has been satisfactorily completed...

33 CFR 127.317 - Declaration of inspection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... handling LNG; (2) The date and time that transfer operations begin; (3) A list of the requirements in § 127... operations and the date and time of signing, indicating that he or she is ready to begin transfer operations... inspection. (a) After the preliminary transfer inspection under § 127.315 has been satisfactorily completed...

33 CFR 127.317 - Declaration of inspection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... handling LNG; (2) The date and time that transfer operations begin; (3) A list of the requirements in § 127... operations and the date and time of signing, indicating that he or she is ready to begin transfer operations... inspection. (a) After the preliminary transfer inspection under § 127.315 has been satisfactorily completed...

33 CFR 127.317 - Declaration of inspection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... handling LNG; (2) The date and time that transfer operations begin; (3) A list of the requirements in § 127... operations and the date and time of signing, indicating that he or she is ready to begin transfer operations... inspection. (a) After the preliminary transfer inspection under § 127.315 has been satisfactorily completed...

Completeness and accuracy of the wisconsin immunization registry: an evaluation coinciding with the beginning of meaningful use.

PubMed

Koepke, Ruth; Petit, Ashley B; Ayele, Roman A; Eickhoff, Jens C; Schauer, Stephanie L; Verdon, Matthew J; Hopfensperger, Daniel J; Conway, James H; Davis, Jeffrey P

2015-01-01

Vaccination coverage rates can be improved through the application of complete and accurate immunization information systems (IISs). Evaluate the completeness and accuracy of Wisconsin's IIS, the Wisconsin Immunization Registry (WIR). Cross-sectional evaluation, comparing vaccination medical records (MRs) from provider clinics with WIR records. Medical records of patients born during 2009 were randomly selected from 251 Wisconsin clinics associated with the Vaccines for Children Program. Completeness: percentage of patients with client records in the WIR, percentage of patients up-to-date (%UTD) with the 4:3:1:3:3:1:4 vaccination series, and percentage of patients' MR vaccinations matched by administration date (±10 days) and type to vaccinations documented in the WIR. Accuracy: percentages of matched vaccinations with the same administration date, same trade name (TN), and same lot number. Of the 1863 selected patient MRs, 98% (n = 1833) had WIR client records and 97% of their 30 899 vaccinations were documented in the WIR. The %UTD was 49.3% using the MR only, 76.5% using the WIR only, and 75.2% as estimated by the National Immunization Survey. Among matched vaccinations, 99% had the same administration date, 96% had the same TN, and 95% had the same lot number. Compared with patients from clinics that entered data into the WIR using data exchange from electronic health records, patients from clinics that entered data using the Web-based user interface were less likely to have client records in the WIR (odds ratio: 0.3; 95% confidence interval: 0.1-0.9) and less likely to have accurate TNs (odds ratio: 0.3; 95% confidence interval: 0.1-0.5). The WIR was complete and accurate among this sample of children born during 2009 and provided a vaccination coverage assessment similar to the National Immunization Survey. Our results provide support for the expectation that meaningful use and other initiatives that increase data exchange from electronic health records to IISs will improve IIS data quality.

Integrated Genomic Biomarkers to Identify Aggressive Disease in African Americans with Prostate Cancer

DTIC Science & Technology

2016-09-01

300 of these men; have completed pathology review of 70 of the discovery sample tumors; macrodissected and performed DNA extraction from 50 tumors...block, and sections cut and tumor areas marked by histopathologist. Target completion September 1st 2017; Discovery sample 35% completed Pathology ...African American population. Target completion March 2017; 50% completed. What was accomplished under these goals? In the current reporting

Tobacco industry targeting youth in Argentina

PubMed Central

Braun, S; Mejia, R; Ling, P M; Pérez-Stable, E J

2013-01-01

Background/aim Argentina has one of the highest cigarette smoking rates among both men and women in the Americas and no legislated restrictions on tobacco industry advertising. The tobacco industry has traditionally expanded markets by targeting adolescents and young adults. The objective of this study was to determine whether and how the tobacco industry promotes cigarettes to adolescents in Argentina. Methods We conducted a systematic search of tobacco industry documents available through the internet dated between 1995 and 2004 using standard search terms to identify marketing strategies in Argentina. A selected review of the four leading newspapers and nine magazines with reported high readership among adolescents was completed. The selected print media were searched for tobacco images and these were classified as advertisements if associated with a commercial product or as a story if not. Results The tobacco industry used market segmentation as a strategy to target Argentinean consumers. British American Tobacco (BAT) undertook a young adult psychographic study and classified them as “progressives”, “Jurassics” or “conservatives” and “crudos” or “spoiled brats”. BAT marketed Lucky Strike to the “progressives” using Hollywood movies as a vehicle. The tobacco industry also targeted their national brands to the conservatives and linked these brands with “nationalistic values” in advertising campaigns. Philip Morris promoted Marlboro by sponsoring activities directed at young people and they launched the 10 cigarettes packet as a starter vehicle. Conclusions The tobacco industry used psychographic segmentation of the population and developed advertising strategies focused on youth. Tobacco control researchers and advocates must be able to address these strategies in counter-marketing interventions. PMID:18299308

Targeted Therapies for Autosomal Dominant Polycystic Kidney Disease.

PubMed

Stayner, Cherie; Brooke, Darby G; Bates, Michael; Eccles, Michael R

2018-05-07

Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease in humans, affecting approximately 1 in 500 people. ADPKD is characterized by cyst growth in the kidney leading to progressive parenchymal damage and is the underlying pathology in approximately 10% of patients requiring hemodialysis or transplantation for end-stage kidney disease. The two proteins that are mutated in ADPKD, polycystin-1 and polycystin-2, form a complex located on the primary cilium and the plasma membrane to facilitate calcium ion release in the cell. There is currently no Food and Drug Administration (FDA)-approved therapy to cure or slow the progression of the disease. Rodent ADPKD models do not completely mimic the human disease, and therefore preclinical results have not always successfully translated to the clinic. Moreover, the toxicity of many of these potential therapies has led to patient withdrawals from clinical trials. Here, we review compounds in a clinical trial for treating ADPKD, and we examine the feasibility of using a kidney-targeted approach, with potential for broadening the therapeutic window, decreasing treatment-associated toxicity and increasing the efficacy of agents that have demonstrated activity in animal models. We make recommendations for integrating kidney-targeted therapies with current treatment regimes, to achieve a combined approach to treating ADPKD. Many compounds are currently in clinical trial for ADPKD, yet to date, none are FDA-approved for treating this disease. Patients could benefit from efficacious pharmacotherapy, especially if it can be kidney-targeted, and intensive efforts continue to be focused on this goal. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Signaling communication events in a computer network

DOEpatents

Bender, Carl A.; DiNicola, Paul D.; Gildea, Kevin J.; Govindaraju, Rama K.; Kim, Chulho; Mirza, Jamshed H.; Shah, Gautam H.; Nieplocha, Jaroslaw

2000-01-01

A method, apparatus and program product for detecting a communication event in a distributed parallel data processing system in which a message is sent from an origin to a target. A low-level application programming interface (LAPI) is provided which has an operation for associating a counter with a communication event to be detected. The LAPI increments the counter upon the occurrence of the communication event. The number in the counter is monitored, and when the number increases, the event is detected. A completion counter in the origin is associated with the completion of a message being sent from the origin to the target. When the message is completed, LAPI increments the completion counter such that monitoring the completion counter detects the completion of the message. The completion counter may be used to insure that a first message has been sent from the origin to the target and completed before a second message is sent.

401(k) plan asset allocation, account balances, and loan activity in 2011.

PubMed

VanDerhei, Jack; Holden, Sarah; Alonso, Luis; Bass, Steven

2012-12-01

THE BULK OF 401(K) ASSETS CONTINUED TO BE INVESTED IN STOCKS: On average, at year-end 2011, 61 percent of 401(k) participants' assets was invested in equity securities through equity funds, the equity portion of balanced funds, and company stock. Thirty-four percent was in fixed-income securities such as stable-value investments and bond and money funds. SEVENTY-TWO PERCENT OF 401(K) PLANS INCLUDED TARGET-DATE FUNDS IN THEIR INVESTMENT LINEUP AT YEAR-END 2011: At year-end 2011, 13 percent of the assets in the EBRI/ICI 401(k) database was invested in target-date funds and 39 percent of 401(k) participants held target-date funds. Also known as lifecycle funds, these funds are designed to offer a diversified portfolio that automatically rebalances to be more focused on income over time. MORE NEW OR RECENT HIRES INVESTED THEIR 401(K) ASSETS IN BALANCED FUNDS, INCLUDING TARGET-DATE FUNDS: For example, at year-end 2011, 51 percent of the account balances of recently hired participants in their 20s was invested in balanced funds, compared with 44 percent in 2010, and about 7 percent in 1998. A significant subset of that balanced fund category is target-date funds. At year-end 2011, 40 percent of the account balances of recently hired participants in their 20s was invested in target-date funds, compared with 35 percent at year-end 2010. 401(K) PARTICIPANTS CONTINUED TO SEEK DIVERSIFICATION OF THEIR INVESTMENTS: The share of 401(k) accounts invested in company stock remained at 8 percent in 2011. This share has fallen by more than half since 1999. Recently hired 401(k) participants contributed to this trend: They tended to be less likely to hold employer stock. PARTICIPANTS' 401(K) LOAN ACTIVITY REMAINED STEADY, ALTHOUGH LOAN BALANCES INCREASED SLIGHTLY IN 2011: At year-end 2011, 21 percent of all 401(k) participants who were eligible for loans had loans outstanding against their 401(k) accounts, unchanged from year-end 2009 and year-end 2010, and up from 18 percent at year-end 2008. Loans outstanding amounted to 14 percent of the remaining account balance, on average, at year-end 2011, unchanged from year-end 2010. Loan amounts outstanding increased slightly from those at year-end 2010. THE YEAR-END 2011 AVERAGE ACCOUNT BALANCE IN THE DATABASE WAS 2.2 PERCENT LOWER THAN THE YEAR BEFORE, BUT MAY NOT ACCURATELY REFLECT THE EXPERIENCE OF TYPICAL 401(K) PARTICIPANTS IN 2011: To understand changes in 401(k) participants' average account balances, it is important to analyze a sample of consistent participants. As with previous EBRI/ICI updates, analysis of a sample of consistent 401(k) participants (those that have been in the same plan since 2003) is expected to be published in 2013.

401(k) plan asset allocation, account balances, and loan activity in 2010.

PubMed

VanDerhei, Jack; Holden, Sarah; Alonso, Luis; Bass, Steven

2011-12-01

THE BULK OF 401(K) ASSETS CONTINUED TO BE INVESTED IN STOCKS: On average, at year-end 2010, 62 percent of 401(k) participants' assets were invested in equity securities through equity funds, the equity portion of balanced funds, and company stock. Thirty-three percent were in fixed-income securities such as stable value investments and bond and money funds. SEVENTY PERCENT OF 401(K) PLANS INCLUDED TARGET-DATE FUNDS IN THEIR INVESTMENT LINEUP AT YEAR-END 2010: At year-end 2010, 11 percent of the assets in the EBRI/ICI 401(k) database were invested in target-date funds and 36 percent of 401(k) participants held target-date funds. Also known as lifecycle funds, they are designed to offer a diversified portfolio that automatically rebalances to be more focused on income over time. MORE NEW OR RECENT HIRES INVESTED THEIR 401(K) ASSETS IN BALANCED FUNDS, INCLUDING TARGET-DATE FUNDS: For example, at year-end 2010, 44 percent of the account balances of recently hired participants in their 20s were invested in balanced funds, compared with 42 percent in 2009, and about 7 percent in 1998. A significant subset of that balanced fund category is target-date funds. At year-end 2010, 35 percent of the account balances of recently hired participants in their 20s were invested in target-date funds, compared with 31 percent at year-end 2009. 401(K) PARTICIPANTS CONTINUED TO SEEK DIVERSIFICATION OF THEIR INVESTMENTS: The share of 401(k) accounts invested in company stock continued to shrink, falling by more than a percentage point (to 8 percent) in 2010, continuing a steady decline that started in 1999. Recently hired 401(k) participants contributed to this trend: They tended to be less likely to hold employer stock. PARTICIPANTS' 401(K) LOAN BALANCES DECLINED SLIGHTLY IN 2010: In 2010, 21 percent of all 401(k) participants who were eligible for loans had loans outstanding against their 401(k) accounts, unchanged from year-end 2009, and up from 18 percent at year-end 2008. Loans outstanding amounted to 14 percent of the remaining account balance, on average, at year-end 2010, compared with 15 percent at year-end 2009. Loan amounts outstanding declined slightly from those in the past few years. THE YEAR-END 2010 AVERAGE ACCOUNT BALANCE IN THE DATABASE WAS 3.4 PERCENT HIGHER THAN THE YEAR BEFORE, BUT MAY NOT ACCURATELY REFLECT THE EXPERIENCE OF TYPICAL 401(K) PARTICIPANTS IN 2010: To understand changes in 401(k) participants' average account balances, it is important to analyze a sample of consistent participants. As with previous EBRI/ICI updates, analysis of a sample of consistent 401(k) participants (those that have been in the same plan since 2003) is expected to be published in 2012.

Economic analysis of threatened species conservation: The case of woodland caribou and oilsands development in Alberta, Canada.

PubMed

Hauer, Grant; Vic Adamowicz, W L; Boutin, Stan

2018-07-15

Tradeoffs between cost and recovery targets for boreal caribou herds, threatened species in Alberta, Canada, are examined using a dynamic cost minimization model. Unlike most approaches used for minimizing costs of achieving threatened species targets, we incorporate opportunity costs of surface (forests) and subsurface resources (energy) as well as direct costs of conservation (habitat restoration and direct predator control), into a forward looking model of species protection. Opportunity costs of conservation over time are minimized with an explicit target date for meeting species recovery targets; defined as the number of self-sustaining caribou herds, which requires that both habitat and population targets are met by a set date. The model was run under various scenarios including three species recovery criteria, two oil and gas price regimes, and targets for the number of herds to recover from 1 to 12. The derived cost curve follows a typical pattern as costs of recovery per herd increase as the number of herds targeted for recovery increases. The results also show that the opportunity costs for direct predator control are small compared to habitat restoration and protection costs. However, direct predator control is essential for meeting caribou population targets and reducing the risk of extirpation while habitat is recovered over time. Copyright © 2018 Elsevier Ltd. All rights reserved.

The effects of moms and teens for safe dates: a dating abuse prevention program for adolescents exposed to domestic violence.

PubMed

Foshee, Vangie A; Benefield, Thad; Dixon, Kimberly S; Chang, Ling-Yin; Senkomago, Virginia; Ennett, Susan T; Moracco, Kathryn E; Michael Bowling, J

2015-05-01

Adolescents exposed to domestic violence are at high risk for dating abuse. This randomized controlled trial evaluated a dating abuse prevention program designed specifically for this risk group. Moms and Teens for Safe Dates consisted of six mailed booklets of dating abuse prevention information and interactive activities. Mothers who had been victims of domestic violence but no longer lived with the abuser delivered the program to their adolescents who had been exposed to the abuse. Mother and adolescent pairs (N = 409) were recruited through community advertising; the adolescents ranged from 12 to 16 years old and 64 % were female. Mothers and adolescents completed baseline and 6-month follow-up telephone interviews. Booklet completion in the treatment group ranged from 80 % for the first to 62 % for the last booklet. The analyses first tested whether program effects on dating abuse varied by four a priori identified moderators (mother's psychological health, the amount of adolescent exposure to domestic violence, and adolescent sex and race/ethnicity). Main effects of the program were examined when there were no differential program effects. Program effects on psychological and physical victimization and psychological and cyber perpetration were moderated by the amount of adolescent exposure to domestic violence; there were significant favorable program effects for adolescents with higher, but not lower levels of exposure to domestic violence. There were no moderated or main effects on sexual violence victimization and perpetration or cyber victimization. The findings suggest that a dating abuse prevention program designed for adolescents exposed to domestic violence can have important positive effects.

Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions

DTIC Science & Technology

2013-08-01

AD_________________ Award Number: W81XWH-12-1-0284 TITLE: Development of Targeted Nanobubbles for...REPORT TYPE Annual 3. DATES COVERED 15 July 2012 - 14 July 2013 4. TITLE AND SUBTITLE Development of Targeted Nanobubbles for Ultrasound...be able to formulate nanodroplets contrast agents with tunable size, PFP content, and shell flexibility to obtain stable and echogenic nanobubbles

Exposure to family violence and attachment styles as predictors of dating violence perpetration among men and women: a mediational model.

PubMed

Lee, Mary; Reese-Weber, Marla; Kahn, Jeffrey H

2014-01-01

This study examined a multiple mediator model explaining how sibling perpetration and one's attachment style mediate the relation between parent-to-child victimization and dating violence perpetration. A sample of undergraduate students (n = 392 women, n = 89 men) completed measures of the aforementioned variables on an Internet survey. For men, path analyses found no mediation; parent-to-child victimization had a direct association with dating violence perpetration, no association was found between sibling perpetration and dating violence perpetration, and attachment anxiety, but not attachment avoidance, was positively associated with dating violence perpetration for men. For women, the hypothesized mediation model was supported; parent-to-child victimization had a direct association with dating violence perpetration, and sibling perpetration and attachment anxiety served as mediating variables. Attachment avoidance was not associated with dating violence perpetration for women. Implications for future research and clinical practice are discussed.

Patterns of Change in Adolescent Dating Victimization and Aggression During Middle School.

PubMed

Goncy, Elizabeth A; Farrell, Albert D; Sullivan, Terri N

2018-03-01

Although mounting evidence suggests dating victimization and aggression begin in early adolescence, little work has examined the pattern of these behaviors across this age. This longitudinal study examined trajectories of dating victimization and aggression across middle school using 12 waves of data. A sample of early adolescents (N = 1369, 52.3% girls; 83% African American; 15% Hispanic or Latino) residing in an urban, economically disadvantaged area participated in this study. Youth completed measures of dating victimization and aggression quarterly across the 3 years of middle school. Although results indicated a general trend of increasing dating victimization and aggression across middle school, variation existed for boys and girls. Specifically, girls showed increasing patterns of both, whereas boys remained relatively stable across time. Dating victimization and aggression were also highly correlated across time. These findings support the implementation and refinement of prevention programming aimed at preventing and reducing dating aggression and victimization in middle school.

[Eccentricity-dependent influence of amodal completion on visual search].

PubMed

Shirama, Aya; Ishiguchi, Akira

2009-06-01

Does amodal completion occur homogeneously across the visual field? Rensink and Enns (1998) found that visual search for efficiently-detected fragments became inefficient when observers perceived the fragments as a partially-occluded version of a distractor due to a rapid completion process. We examined the effect of target eccentricity in Rensink and Enns's tasks and a few additional tasks by magnifying the stimuli in the peripheral visual field to compensate for the loss of spatial resolution (M-scaling; Rovamo & Virsu, 1979). We found that amodal completion disrupted the efficient search for the salient fragments (i.e., target) even when the target was presented at high eccentricity (within 17 deg). In addition, the configuration effect of the fragments, which produced amodal completion, increased with eccentricity while the same target was detected efficiently at the lowest eccentricity. This eccentricity effect is different from a previously-reported eccentricity effect where M-scaling was effective (Carrasco & Frieder, 1997). These findings indicate that the visual system has a basis for rapid completion across the visual field, but the stimulus representations constructed through amodal completion have eccentricity-dependent properties.

Prevalence of primary outcome changes in clinical trials registered on ClinicalTrials.gov: a cross-sectional study.

PubMed

Ramagopalan, Sreeram; Skingsley, Andrew P; Handunnetthi, Lahiru; Klingel, Michelle; Magnus, Daniel; Pakpoor, Julia; Goldacre, Ben

2014-01-01

An important principle in the good conduct of clinical trials is that a summary of the trial protocol, with a pre-defined primary outcome, should be freely available before the study commences. The clinical trials registry ClinicalTrials.gov provides one method of doing this, and once the trial is registered, any changes made to the primary outcome are documented. The objectives of this study were: to assess the proportion of registered trials on ClinicalTrials.gov that had the primary outcome changed; to assess when the primary outcome was changed in relation to the listed study start and end dates and to assess whether the primary outcome change had any relation to the study sponsor. A cross-sectional analysis of all interventional clinical trials registered on ClinicalTrials.gov as of 25 October 2012 was performed. The main outcome was any change made to the initially listed primary outcome and the time of the change in relation to the trial start and end date. Our analysis showed that 28229 of 89204 (31.7%) registered studies had their primary outcome changed.  Industry funding was associated with all primary outcome changes, odds ratio (OR)= 1.36, 95% confidence interval (CI)=1.31-1.41, p<0.001; with primary outcome changes after study start date OR=1.37, 95% CI=1.32-1.42, p<0.001; with primary outcome changes after primary completion date OR=1.84, 95% CI=1.75-1.94, p<0.001 and with primary outcome changes after study completion date OR=1.82, 95% CI=1.73-1.91, p<0.001.  Conclusions A significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates. These changes are associated with funding source.

Procedures for Completion and Use of FAA Form 8130-3, Airworthiness Approval Tag

DOT National Transportation Integrated Search

1994-01-03

This order revises the procedures contained in Order 8130.21, Completion and Use of Federal Aviation Administration (FAA) Form 8130-3, Airworthiness Approval Tag (herein referred to as "the form") dated June 21, 1991. : Specifically, this revision co...

Research notes : ensuring project performance and adherence to completion dates.

DOT National Transportation Integrated Search

2009-04-01

A recently completed ODOT research project, led by David Sillars at Oregon State University, sought to identify alternative methods to liquidated damages for ODOT to encourage on-time project delivery and to develop a model to aid in selecting among ...

34 CFR 263.9 - When does payback begin?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF EDUCATION INDIAN EDUCATION DISCRETIONARY GRANT PROGRAMS Professional Development Program § 263... Professional Development program, payback shall begin within six months from the date of completion of the training. (b) For participants who do not complete their training under the Professional Development...

Removing Barriers to High School Completion--Technical Report. System Improvement and Reporting.

ERIC Educational Resources Information Center

Alberta Learning, Edmonton.

The ability of every student to successfully complete high school is fundamental to continued success and quality of life. As such, Alberta Learning's 2000-2003 Business Plan has set a target for improving high school completion by 19-year-old students from 70% to 75%. A key step to achieving this target has involved completing a study of barriers…

Mitogenome Phylogenetics: The Impact of Using Single Regions and Partitioning Schemes on Topology, Substitution Rate and Divergence Time Estimation

PubMed Central

Duchêne, Sebastián; Archer, Frederick I.; Vilstrup, Julia; Caballero, Susana; Morin, Phillip A.

2011-01-01

The availability of mitochondrial genome sequences is growing as a result of recent technological advances in molecular biology. In phylogenetic analyses, the complete mitogenome is increasingly becoming the marker of choice, usually providing better phylogenetic resolution and precision relative to traditional markers such as cytochrome b (CYTB) and the control region (CR). In some cases, the differences in phylogenetic estimates between mitogenomic and single-gene markers have yielded incongruent conclusions. By comparing phylogenetic estimates made from different genes, we identified the most informative mitochondrial regions and evaluated the minimum amount of data necessary to reproduce the same results as the mitogenome. We compared results among individual genes and the mitogenome for recently published complete mitogenome datasets of selected delphinids (Delphinidae) and killer whales (genus Orcinus). Using Bayesian phylogenetic methods, we investigated differences in estimation of topologies, divergence dates, and clock-like behavior among genes for both datasets. Although the most informative regions were not the same for each taxonomic group (COX1, CYTB, ND3 and ATP6 for Orcinus, and ND1, COX1 and ND4 for Delphinidae), in both cases they were equivalent to less than a quarter of the complete mitogenome. This suggests that gene information content can vary among groups, but can be adequately represented by a portion of the complete sequence. Although our results indicate that complete mitogenomes provide the highest phylogenetic resolution and most precise date estimates, a minimum amount of data can be selected using our approach when the complete sequence is unavailable. Studies based on single genes can benefit from the addition of a few more mitochondrial markers, producing topologies and date estimates similar to those obtained using the entire mitogenome. PMID:22073275

Impact of Patient Reminders on Papanicolaou Test Completion for High-Risk Patients Identified by a Clinical Decision Support System.

PubMed

MacLaughlin, Kathy L; Kessler, Maya E; Komandur Elayavilli, Ravikumar; Hickey, Branden C; Scheitel, Marianne R; Wagholikar, Kavishwar B; Liu, Hongfang; Kremers, Walter K; Chaudhry, Rajeev

2018-05-01

A clinical decision support system (CDSS) for cervical cancer screening identifies patients due for routine cervical cancer screening. Yet, high-risk patients who require more frequent screening or earlier follow-up to address past abnormal results are not identified. We aimed to assess the effect of a complex CDSS, incorporating national guidelines for high-risk patient screening and abnormal result management, its implementation to identify patients overdue for testing, and the outcome of sending a targeted recommendation for follow-up. At three primary care clinics affiliated with an academic medical center, a reminder recommending an appointment for Papanicolaou (Pap) testing or Pap and human papillomavirus cotesting was sent to high-risk women aged 18 through 65 years (intervention group) identified by CDSS as overdue for testing. Historical control patients, who did not receive a reminder, were identified by CDSS 1 year before the date when reminders were sent to the intervention group. Test completion rates were compared between the intervention and control groups through a generalized estimating equation extension. Across the three sites, the average completion rate of recommended follow-up testing was significantly higher in the intervention group at 23.7% (61/257) than the completion rate at 3.3% (17/516) in the control group (p < 0.001). A CDSS with enhanced capabilities to identify high-risk women due for cervical cancer testing beyond routine screening intervals, with subsequent patient notification, has the potential to decrease cervical precancer and cancer by improving adherence to guideline-compliant follow-up and needed treatment.

A survey of silage management practices on California dairies.

PubMed

Heguy, J M; Meyer, D; Silva-Del-Río, N

2016-02-01

The aim of the present study was to gather baseline information on corn silage-management practices to develop an outreach curriculum for dairy producers and growers. In spring 2013, dairy producers in the San Joaquin Valley (California) were surveyed on their silage-management practices. Response rate was 14.5% (n=160) and herd size averaged 1,512 milking cows. Harvest date was set solely by the dairy producer (53.4%) or with the assistance of the crop manager, custom chopper, or nutritionist (23.3%). On some dairies (23.3%), the dairy producer delegated the harvest date decision. Most dairies (75.0%) estimated crop dry matter before harvest, and the preferred method was milk line evaluation. Dairy producers were mostly unfamiliar with harvest rate but the number [1 (35.9%), 2 (50.3%), or 3 to 5 (13.8%)] and size [6-row (17.7%), 8-row (67.3%), or 10-row (15.0%)] of choppers working simultaneously was reported. Most dairies used a single packing tractor (68.8%) and weighed every load of fresh chopped corn delivered to the silage pit (62%). During harvest, dry matter (66.9%), particle length (80.4%), and kernel processing (92.5%) were monitored. Most dairies completed filling their largest silage structure in less than 3 d (48.5%) or in 4 to 7 d (30.9%). Silage covering was completed no later than 7 2h after structure completion in all dairies, and was often completed within 24 h (68.8%). Packed forage was covered as filled in 19.6% of dairies. Temporary covers were used on some dairies (51.0%), with filling durations of 1 to 60 d. When temporary covers were not used, structures were filled in no more than 15 d. After structure closure, silage feedout started in 1 to 3 wk (44.4%), 4 to 5 wk (31.4%), or 8 or more wk (24.2%). Future considerations included increasing the silage storage area (55.9%), increasing the number of packing tractors (37.0%), planting brown mid-rib varieties (34.4%), buying a defacer to remove silage (33.1%), and creating drive-over piles (32.6%). Survey results will serve to develop and disseminate targeted information on silage management practices at harvest, packing, covering, and feedout on California's San Joaquin Valley dairies. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Depressive Symptoms Moderate Dating Violence Prevention Outcomes Among Adolescent Girls.

PubMed

Collibee, Charlene; Rizzo, Christie J; Kemp, Kathleen; Hood, Erik; Doucette, Hannah; Gittins Stone, Daniel I; DeJesus, Brett

2018-04-01

Few dating violence prevention programs assess how variations in initial violence risk affects responsiveness. This study examines the efficacy of Date SMART, a dating violence and sexual risk prevention program designed to target high-risk adolescent girls, in preventing dating violence in the context of varying initial levels of depressive symptoms. A diverse sample of N = 109 female adolescents with a history of physical dating violence participated in a randomized controlled trial of the Date SMART program and a knowledge only (KO) comparison. Using baseline depression level as a primary risk factor, a series of multilevel models revealed significant main effects of baseline depression such that higher baseline depression was associated with greater physical dating violence perpetration and victimization. Results also showed a three-way interaction for assessment point, depressive symptoms, and condition for physical dating violence perpetration. Specifically, those with higher baseline depression in Date SMART showed significantly less physical dating violence perpetration at follow-ups compared with those with higher baseline depression in the KO group. This difference in violence reduction between conditions was not observed for those with lower baseline depression. Date SMART appears to effectively reduce physical dating violence perpetration in those with higher levels of initial risk. Current findings support that adolescents with different risk profiles respond differently to violence prevention programs.

ESR dating of barite in sulphide deposits formed by the sea-floor hydrothermal activities.

PubMed

Toyoda, Shin; Fujiwara, Taisei; Uchida, Ai; Ishibashi, Jun-ichiro; Nakai, Shun'ichi; Takamasa, Asako

2014-06-01

Barite is a mineral newly found to be practically useful for electron spin resonance (ESR) dating of sulphide deposits formed by the sea-floor hydrothermal activities. The recent studies for the properties of the ESR dating signal in barite are summarised in the present paper as well as the formulas for corrections for accurate dose-rate estimation are developed including the dose-rate conversion factors, shape correction for gamma-ray dose and decay of (226)Ra. Although development of the techniques for ESR dating of barite has been completed, further comparative studies with other dating techniques such as U-Th and (226)Ra-(210)Pb dating are necessary for the technique to be widely used. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

The Role of Acceptance of Violence Beliefs and Social Information Processing on Dating Violence Perpetration.

PubMed

Fernández-González, Liria; Calvete, Esther; Orue, Izaskun

2018-06-13

This study's main objective was to explore whether beliefs legitimizing dating violence predict dysfunctional social information processing (SIP) when adolescents deal with ambiguous dating situations, and whether this more proximal cognitive processing acts as a mediator between acceptance of violence beliefs and dating violence perpetration. Participants were 855 high school students who completed self-report measures at three time points, with a 1-year interval between them. SIP did not act as a mediator, but the emergence of anger emotions in dating conflict situations, along with aggression-justifying beliefs, were revealed as essential in explaining dating violence. Previous aggression also explained a subsequent higher anticipation of positive consequences for aggressive acts. We discuss the implications for prevention and treatment strategies with adolescents. © 2018 Society for Research on Adolescence.

Trajectories of dating violence: Differences by sexual minority status and gender.

PubMed

Martin-Storey, Alexa; Fromme, Kim

2016-06-01

The purpose of this study was to examine how sexual minority status (as assessed using both identity and behavior) was associated with trajectories of dating violence. University students from a large Southwestern university completed questions on their sexual minority identity, the gender of their sexual partners, and about experiences of dating violence for six consecutive semesters (N = 1942). Latent growth curve modeling indicated that generally, trajectories of dating violence were stable across study participation. Sexual minority identity was associated with higher initial levels of dating violence at baseline, but also with greater decreases in dating violence across time. These differences were mediated by number of sexual partners. Having same and other-sex sexual partners was associated with higher levels of dating violence at baseline, and persisted in being associated with higher levels over time. No significant gender difference was observed regarding trajectories of dating violence. Copyright © 2016 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

The Acceptance of Dating Violence scale (ADV): Psychometric properties of the Spanish version.

PubMed

Fernández-González, Liria; Calvete, Esther; Orue, Izaskun

2017-05-01

The main aim of this study was to analyse the psychometric properties of the Spanish version of the Acceptance of Dating Violence (ADV) scale, which assesses attitudes that justify the use of aggression in adolescents’ dating relationships. A total of 1,579 high school students (49% girls) from Bizkaia (Spain), aged between 14 and 18 years (M = 15.79, SD = 1.16), completed this questionnaire along with the Irrational Beliefs Scale for Adolescents and the Conflict in Adolescent Dating Relationships Inventory. The factor analyses suggested a one-factor structure, which fits data well for both girls and boys. Moreover, the ADV showed good internal consistency (α = .83) and was related to general justification of violence and dating violence (perpetration and victimization). Boys (compared to girls) and adolescents who had had a dating relationship in the past year (compared to those who had not) displayed a higher acceptance of dating violence. The ADV is a useful, brief and easily applicable instrument for the assessment of attitudes toward dating violence.

48 CFR 3015.606-2 - Evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Evaluation. 3015.606-2... Unsolicited Proposals 3015.606-2 Evaluation. (a) Comprehensive evaluations should be completed within sixty... contact point shall advise the offeror accordingly and provide a new evaluation completion date. The...

Radiocarbon dating of terrestrial carbonates

USGS Publications Warehouse

Pigati, Jeffrey S.; Rink, W. Jack; Thompson, Jeroen

2014-01-01

Terrestrial carbonates encompass a wide range of materials that potentially could be used for radiocarbon (14C) dating. Biogenic carbonates, including shells and tests of terrestrial and aquatic gastropods, bivalves, ostracodes, and foraminifera, are preserved in a variety of late Quaternary deposits and may be suitable for 14C dating. Primary calcareous deposits (marls, tufa, speleothems) and secondary carbonates (rhizoliths, fracture fill, soil carbonate) may also be targeted for dating when conditions are favorable. This chapter discusses issues that are commonly encountered in 14C dating of terrestrial carbonates, including isotopic disequilibrium and open-system behavior, as well as methods used to determine the reliability of ages derived from these materials. Recent methodological advancements that may improve the accuracy and precision of 14C ages of terrestrial carbonates are also highlighted.

Dating Violence and Sexual Risk Behaviors in a Sample of At-Risk Israeli Youth

ERIC Educational Resources Information Center

Schiff, Miriam; Zeira, Anat

2005-01-01

Objective: This exploratory study examines the reported dating violence and its association with sexual risk behavior among Israeli adolescents, who are at risk for dropping out of school. Methodology: A convenience sample of 105 at-risk youth (51 boys and 54 girls) completed self-administered anonymous, questionnaires in small same-gender groups.…

76 FR 44872 - Effective Date of Requirement for Premarket Approval for an Implantable Pacemaker Pulse Generator

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

... triggered, inhibited, and asynchronous devices implanted in the human body. B. Summary of Data The... human body. * * * * * (c) Date PMA or notice of completion of PDP is required. A PMA or notice of... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 870 [Docket No...

31 CFR 321.8 - Redemption-exchange of Series E and EE savings bonds and savings notes.

Code of Federal Regulations, 2012 CFR

2012-07-01

... eligible for exchange are: (1) Series EE bonds bearing issue dates of January 1, 2003, or earlier... February 1, 2003, or thereafter, presented no earlier than 12 months from their issue dates; and (3) Series... securities on exchange unless: (1) The securities are accompanied by a completed exchange subscription signed...

48 CFR Appendix B to Part 1232 - Instructions for Completing the SF 1035

Code of Federal Regulations, 2010 CFR

2010-10-01

... generally entered below the line with Number and Date of Order; Date of Delivery or Service; Articles or... of data to be inserted as it applies to the contract or order number. a. Show, as applicable, the... Government's interest. b. Show the following costs and supporting data (as applicable) to the contract or...

New High Gain Target Design for a Laser Fusion Power Plant

DTIC Science & Technology

2000-06-07

target with a minimum energy gain, about 100. Demonstration of ignition or low gain is only important for fusion energy if it leads into a target concept...nonlinear saturation of these instabilities. Our approach is to try to avoid them. 4. A Development Path to Fusion Energy The laser and target concept...on the exact date required to develop fusion energy , it would be worthwhile for a power plant development program to provide enough time and funds

The invisible stereotypes of bisexual men.

PubMed

Zivony, Alon; Lobel, Thalma

2014-08-01

Bisexual men have little public visibility, yet previous reports indicate that heterosexuals have specific prejudicial attitudes towards them. This article reports on two studies that examined the stereotypical beliefs of heterosexual men and women regarding bisexual men. In Study 1 (n = 88), we examined awareness of social stereotypes (stereotype knowledge). Most of the participants were unable to describe the various stereotypes of bisexual men. Contrary to previous studies, low-prejudiced participants had more stereotype knowledge than high-prejudiced participants. In Study 2 (n = 232), we examined prejudice in a contextual evaluation task that required no stereotype knowledge. Participants evaluated a single target character on a first date: a bisexual man dating a heterosexual woman, a bisexual man dating a gay man, a heterosexual man dating a heterosexual woman, or a gay man dating a gay man. The findings indicated that participants implemented stereotypical beliefs in their evaluation of bisexual men: compared to heterosexual and gay men, bisexual men were evaluated as more confused, untrustworthy, open to new experiences, as well as less inclined towards monogamous relationships and not as able to maintain a long-term relationship. Overall, the two studies suggest that the stereotypical beliefs regarding bisexual men are prevalent, but often not acknowledged as stereotypes. In addition, the implementation of stereotypes in the evaluations was shown to be dependent on the potential romantic partner of the target. Possible theoretical explanations and implications are discussed.

Men Who Compliment a Woman's Appearance Using Metaphorical Language: Associations with Creativity, Masculinity, Intelligence and Attractiveness

PubMed Central

Gao, Zhao; Yang, Qi; Ma, Xiaole; Becker, Benjamin; Li, Keshuang; Zhou, Feng; Kendrick, Keith M.

2017-01-01

Language may have evolved as a signal of mental fitness. However, it remains unclear what language form and topic men use to covertly signal mate quality. In this study 69 men created compliments to impress unfamiliar women they chose to either date or work with and provided hand scans to compute 2D4D ratio as a proxy for prenatal testosterone exposure and masculinity indicator. Compliments were coded in terms of form (literal vs. metaphorical) and topic (women's appearance vs. non-appearance), with metaphorical ones being subsequently rated by 114 women for psycholinguistic features, indices of intelligence and willingness to have a romantic relationship with the author. Results showed that in a dating context, men produced more metaphorical form compliments targeting appearance compared to the working context and they were associated with men's art creativity and negatively with 2D4D ratio (i.e., positively with masculinity). Women preferred establishing a romantic relationship with a higher proportion of the men producing metaphorical compliments in a dating than a working context. Furthermore, in the dating but not the working context, women perceived men producing such compliments as being more intelligent, and importantly this correlated with the men's actual verbal intelligence. Overall, findings suggest that men may use metaphorical language compliments targeting women's appearance in a dating context to signal covertly their mate quality. PMID:29312054

Men Who Compliment a Woman's Appearance Using Metaphorical Language: Associations with Creativity, Masculinity, Intelligence and Attractiveness.

PubMed

Gao, Zhao; Yang, Qi; Ma, Xiaole; Becker, Benjamin; Li, Keshuang; Zhou, Feng; Kendrick, Keith M

2017-01-01

Language may have evolved as a signal of mental fitness. However, it remains unclear what language form and topic men use to covertly signal mate quality. In this study 69 men created compliments to impress unfamiliar women they chose to either date or work with and provided hand scans to compute 2D4D ratio as a proxy for prenatal testosterone exposure and masculinity indicator. Compliments were coded in terms of form (literal vs. metaphorical) and topic (women's appearance vs. non-appearance), with metaphorical ones being subsequently rated by 114 women for psycholinguistic features, indices of intelligence and willingness to have a romantic relationship with the author. Results showed that in a dating context, men produced more metaphorical form compliments targeting appearance compared to the working context and they were associated with men's art creativity and negatively with 2D4D ratio (i.e., positively with masculinity). Women preferred establishing a romantic relationship with a higher proportion of the men producing metaphorical compliments in a dating than a working context. Furthermore, in the dating but not the working context, women perceived men producing such compliments as being more intelligent, and importantly this correlated with the men's actual verbal intelligence. Overall, findings suggest that men may use metaphorical language compliments targeting women's appearance in a dating context to signal covertly their mate quality.

KSC-08pd3188

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the payload canister with the Hubble Space Telescope equipment moves into the Payload Hazardous Servicing Facility, or PHSF. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3192

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the payload canister with the Hubble Space Telescope equipment is in a clean room inside the Payload Hazardous Servicing Facility, or PHSF. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3190

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the payload canister with the Hubble Space Telescope equipment moves inside the Payload Hazardous Servicing Facility, or PHSF. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3191

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the payload canister with the Hubble Space Telescope equipment is inside the Payload Hazardous Servicing Facility, or PHSF. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3193

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the payload canister with the Hubble Space Telescope equipment is in a clean room inside the Payload Hazardous Servicing Facility, or PHSF. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3189

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the payload canister with the Hubble Space Telescope equipment moves into the Payload Hazardous Servicing Facility, or PHSF. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3131

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ HST payload inside rolls past the Vehicle Assembly Building, behind it. The payload comprises four carriers holding various equipment for the mission. The hardware will be transported back to Kennedy’s Payload Hazardous Servicing Facility where it will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Tim Jacobs

Targeting Stromal Recruitment by Prostate Cancer Cells

DTIC Science & Technology

2006-03-01

Ensinger, C., Tumer , Z., Tommerup, N. et al.: Hedgehog signaling in small-cell lung cancer : frequent in vivo but a rare event in vitro. Lung Cancer , 52...W81XWH-04-1-0157 TITLE: Targeting Stromal Recruitment by Prostate Cancer Cells PRINCIPAL INVESTIGATOR: Jingxian Zhang, Ph.D...DATES COVERED (From - To) 15 Feb 2004 – 14 Feb 2006 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Targeting Stromal Recruitment by Prostate Cancer

Genomic Alterations in Advanced Esophageal Cancer May Lead to Subtype-Specific Therapies

PubMed Central

Forde, Patrick M.

2013-01-01

The development of targeted agents for metastatic esophageal or gastroesophageal junction (GEJ) tumors has been limited when compared with that for other common tumors. To date, the anti-human epidermal growth factor receptor-2 (HER-2) antibody, trastuzumab, in combination with chemotherapy, is the only approved novel agent for these cancers, and its use is limited to the small population of patients whose tumors overexpress HER-2. Despite recent progress in the field, median overall survival remains only 8–12 months for patients with stage IV esophageal or GEJ cancer. In this article, we examine the molecular aberrations thought to drive the development and spread of esophageal cancer and identify promising targets for specific tumor inhibition. Data from clinical studies of targeted agents are reviewed, including epidermal growth factor receptor antibodies, tyrosine kinase inhibitors, HER-2, and vascular endothelial growth factor-directed therapy. Current and future targets include MET, fibroblast growth factor receptor, and immune-based therapies. Evidence from trials to date suggests that molecularly unselected patient cohorts derive minimal benefit from most target-specific agents, suggesting that future collaborative investigation should focus on preselected molecular subgroups of patients with this challenging heterogeneous disease. PMID:23853247

Longitudinal Mediators of Relations Between Family Violence and Adolescent Dating Aggression Perpetration

PubMed Central

Reyes, H. Luz McNaughton; Foshee, Vangie A.; Fortson, Beverly L.; Valle, Linda A.; Breiding, Matthew J.; Merrick, Melissa T.

2015-01-01

Few longitudinal studies have examined the pathways through which family violence leads to dating aggression. In the current study the authors used 3 waves of data obtained from 8th- and 9th-grade adolescents (N = 1,965) to examine the hypotheses that the prospective relationship between witnessing family violence and directly experiencing violence and physical dating aggression perpetration is mediated by 3 constructs: (a) normative beliefs about dating aggression (norms), (b) anger dysregulation, and (c) depression. Results from cross-lagged regression models suggest that the relationship between having been hit by an adult and dating aggression is mediated by changes in norms and anger dysregulation, but not depression. No evidence of indirect effects from witnessing family violence to dating aggression was found through any of the proposed mediators. Taken together, the findings suggest that anger dysregulation and normative beliefs are potential targets for dating abuse prevention efforts aimed at youth who have directly experienced violence. PMID:26719602

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2012 CFR

2012-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2014 CFR

2014-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2011 CFR

2011-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

25 CFR 163.42 - Obligated service and breach of contract.

Code of Federal Regulations, 2013 CFR

2013-04-01

... REGULATIONS Forestry Education, Education Assistance, Recruitment and Training § 163.42 Obligated service and breach of contract. (a) Obligated service. (1) Individuals completing forestry education programs with an... 90 days of the date all program education requirements have been completed. If such employment is not...

Preparing for the Millennium.

ERIC Educational Resources Information Center

Scaglione, Chris

1998-01-01

In 2000, any automated system that processes dates may stop working completely or produce unexpected or unwanted results. School administrators should obtain a complete listing of all currently used systems, prioritize them, contact hardware and software providers to verify Y2K compliance, develop resolution plans with vendors, develop assessment…

49 CFR 1540.203 - Security threat assessment.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... (3) Date and place of birth. (4) Social security number (submission is voluntary, although failure to provide it may delay or prevent completion of the threat assessment). (5) Gender. (6) Country of... Border Protection. (i) If asserting completion of a comparable threat assessment listed in paragraph (h...

49 CFR 1540.203 - Security threat assessment.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... (3) Date and place of birth. (4) Social security number (submission is voluntary, although failure to provide it may delay or prevent completion of the threat assessment). (5) Gender. (6) Country of... Border Protection. (i) If asserting completion of a comparable threat assessment listed in paragraph (h...

1995 feels so close yet so far: the effect of event markers on subjective feelings of elapsed time.

PubMed

Zauberman, Gal; Levav, Jonathan; Diehl, Kristin; Bhargave, Rajesh

2010-01-01

Why does an event feel more or less distant than another event that occurred around the same time? Prior research suggests that characteristics of an event itself can affect the estimated date of its occurrence. Our work differs in that we focused on how characteristics of the time interval following an event affect people's feelings of elapsed time (i.e., their feelings of how distant an event seems). We argue that a time interval that is punctuated by a greater number of accessible intervening events related to the target event (event markers) will make the target event feel more distant, but that unrelated intervening events will not have this effect. In three studies, we found support for the systematic effect of event markers. The effect of markers was independent of other characteristics of the event, such as its memorability, emotionality, importance, and estimated date, a result suggesting that this effect is distinct from established dating biases.

A Review of Teen Dating Violence Prevention Research: What About Hispanic Youth?

PubMed

Malhotra, Krithika; Gonzalez-Guarda, Rosa M; Mitchell, Emma M

2015-10-01

The purpose of this article is to provide a critical review of the literature on evidence-based teen dating violence (TDV) prevention programs with a particular focus on highlighting gaps in the literature with regard to prevention efforts targeting Hispanic teens. The target populations, characteristics, designs, and results of TDV prevention studies reported in the scientific literature for the last 20 years were reviewed and analyzed according to cultural and contextual factors associated with TDV among Hispanic teens. To date, three studies have focused on a predominantly Hispanic population with only one study looking at the long-term effects of a TDV intervention. There is a growing need to develop and evaluate immediate and long-term effects of TDV prevention programs that address ethnic pride, acculturation and acculturative stress, familism, and gender norms within the context of Hispanic communities (e.g., machismo and marianismo). The authors discuss the implications for research, prevention practice, and policy regarding TDV prevention for Hispanic teens. © The Author(s) 2014.

Effects of Cognitive Distortions on the Link Between Dating Violence Exposure and Substance Problems in Clinically Hospitalized Youth.

PubMed

Miller, Adam Bryant; Williams, Caitlin; Day, Catherine; Esposito-Smythers, Christianne

2017-06-01

The purpose of the present study was to examine whether cognitive distortions (e.g., cognitive errors; negative views of self, world, and future) influence the association between dating violence and problematic substance use behaviors in a sample of psychiatrically hospitalized adolescents. Participants included 155 adolescents, aged 13-17 years, who had initiated dating. Adolescents completed measures of dating violence, substance-related problems (alcohol and marijuana), and cognitive distortions. Logistic regressions were conducted to examine the direct and interactive effects of dating violence exposure and cognitive distortions on likelihood of recent problematic substance use. Results suggested a main effect of dating violence on problematic alcohol and other drug use as well as an interactive effect of dating violence and cognitive distortions. Specifically, the relationship between dating violence and odds of substance-related problems was higher among those with greater (vs. fewer) cognitive distortions. Study results suggest the need for careful screening of cognitive distortions among adolescent dating violence victims, particularly those in mental health treatment. © 2016 Wiley Periodicals, Inc.

Effects of Cognitive Distortions on the Link Between Dating Violence Exposure and Substance Problems in Clinically Hospitalized Youth

PubMed Central

Miller, Adam Bryant; Williams, Caitlin; Esposito-Smythers, Christianne

2016-01-01

Purpose The purpose of the present study was to examine whether cognitive distortions (e.g., cognitive errors; negative views of self, world, and future) influence the association between dating violence and problematic substance use behaviors in a sample of psychiatrically hospitalized adolescents. Methods Participants included 155 adolescents, ages 13 to 17, who had initiated dating. Adolescents completed measures of dating violence, substance related problems, (alcohol and marijuana), and cognitive distortions. Results Logistic regressions were conducted to examine the direct and interactive effects of dating violence exposure and cognitive distortions on likelihood of recent problematic substance use. Results suggested a main effect of dating violence on problematic alcohol and other drug use as well as an interactive effect of dating violence and cognitive distortions. Specifically, the relationship between dating violence and odds of substance related problems were higher among those with greater (vs. fewer) cognitive distortions. Conclusions Study results suggest the need for careful screening of cognitive distortions among adolescent dating violence victims, particularly those in mental health treatment. PMID:27552530

Lexical Retrieval of Nouns and Verbs in a Sentence Completion Task

ERIC Educational Resources Information Center

Abel, Alyson D.; Maguire, Mandy J.; Naqvi, Fizza M.; Kim, Angela Y.

2015-01-01

This study explored noun and verb retrieval using a sentence completion task to expand upon previous findings from picture naming tasks. Participants completed sentences missing either a target noun or verb in the final position. Non-target responses were coded for substitution type, imageability and frequency. Like picture naming, nouns and verbs…

Trial publication after registration in ClinicalTrials.Gov: a cross-sectional analysis.

PubMed

Ross, Joseph S; Mulvey, Gregory K; Hines, Elizabeth M; Nissen, Steven E; Krumholz, Harlan M

2009-09-01

ClinicalTrials.gov is a publicly accessible, Internet-based registry of clinical trials managed by the US National Library of Medicine that has the potential to address selective trial publication. Our objectives were to examine completeness of registration within ClinicalTrials.gov and to determine the extent and correlates of selective publication. We examined reporting of registration information among a cross-section of trials that had been registered at ClinicalTrials.gov after December 31, 1999 and updated as having been completed by June 8, 2007, excluding phase I trials. We then determined publication status among a random 10% subsample by searching MEDLINE using a systematic protocol, after excluding trials completed after December 31, 2005 to allow at least 2 y for publication following completion. Among the full sample of completed trials (n = 7,515), nearly 100% reported all data elements mandated by ClinicalTrials.gov, such as intervention and sponsorship. Optional data element reporting varied, with 53% reporting trial end date, 66% reporting primary outcome, and 87% reporting trial start date. Among the 10% subsample, less than half (311 of 677, 46%) of trials were published, among which 96 (31%) provided a citation within ClinicalTrials.gov of a publication describing trial results. Trials primarily sponsored by industry (40%, 144 of 357) were less likely to be published when compared with nonindustry/nongovernment sponsored trials (56%, 110 of 198; p<0.001), but there was no significant difference when compared with government sponsored trials (47%, 57 of 122; p = 0.22). Among trials that reported an end date, 75 of 123 (61%) completed prior to 2004, 50 of 96 (52%) completed during 2004, and 62 of 149 (42%) completed during 2005 were published (p = 0.006). Reporting of optional data elements varied and publication rates among completed trials registered within ClinicalTrials.gov were low. Without greater attention to reporting of all data elements, the potential for ClinicalTrials.gov to address selective publication of clinical trials will be limited. Please see later in the article for the Editors' Summary.

GEO Optical Data Association with Concurrent Metric and Photometric Information

NASA Astrophysics Data System (ADS)

Dao, P.; Monet, D.

Data association in a congested area of the GEO belt with occasional visits by non-resident objects can be treated as a Multi-Target-Tracking (MTT) problem. For a stationary sensor surveilling the GEO belt, geosynchronous and near GEO objects are not completely motionless in the earth-fixed frame and can be observed as moving targets. In some clusters, metric or positional information is insufficiently accurate or up-to-date to associate the measurements. In the presence of measurements with uncertain origin, star tracks (residuals) and other sensor artifacts, heuristic techniques based on hard decision assignment do not perform adequately. In the MMT community, Bar-Shalom [2009 Bar-Shalom] was first in introducing the use of measurements to update the state of the target of interest in the tracking filter, e.g. Kalman filter. Following Bar-Shalom’s idea, we use the Probabilistic Data Association Filter (PDAF) but to make use of all information obtainable in the measurement of three-axis-stabilized GEO satellites, we combine photometric with metric measurements to update the filter. Therefore, our technique Concurrent Spatio- Temporal and Brightness (COSTB) has the stand-alone ability of associating a track with its identity –for resident objects. That is possible because the light curve of a stabilized GEO satellite changes minimally from night to night. We exercised COSTB on camera cadence data to associate measurements, correct mistags and detect non-residents in a simulated near real time cadence. Data on GEO clusters were used.

The influence of HIV disease events/stages on smoking attitudes and behaviors: project STATE (Study of Tobacco Attitudes and Teachable Events)

PubMed Central

2014-01-01

Background Given the increase in life expectancy among HIV-positive individuals attributable to antiretroviral therapies, cigarette smoking now represents one of the most salient health risks confronting the HIV-positive population. Despite this risk, very few efforts to date have been made to target persons living with HIV for smoking cessation treatment, and no efforts have been made to explore the role of cognitions and HIV disease events/stages on smoking outcomes. The purpose of the study, Project STATE (Study of Tobacco Attitudes and Teachable Events), is to prospectively examine the relationship between HIV events/stages, perceived impact of HIV disease, attitudes about cigarette smoking, and smoking behaviors. Methods/Design This study employs a prospective design. Patients are recruited at the time of their first physician visit at a large inner city HIV-clinic – Thomas Street Health Center (TSHC). Consenting participants then complete a baseline assessment. All participants are offered standard care smoking cessation treatment. Follow-up assessments are completed on four subsequent occasions: 3, 6, 9, and 12 months post-baseline. These follow-up assessments are scheduled to coincide with routine clinic appointments with their TSHC physicians. In addition, each participant is given a prepaid cell phone at the time of enrollment and asked to complete brief phone assessments weekly for the first three months of the study period. Discussion By evaluating events/stages of HIV disease as potential teaching moments for smoking cessation, findings from this study could be used to develop treatments tailored to an individual’s stage of HIV disease. This study design will enable us to carefully track changes in smoking behavior over time, and to link these changes to both the course of HIV disease and/or to the participant’s’ perceived impact of HIV. By identifying optimal time points for intervention, the findings from this study will have the potential to maximize the efficiency and efficacy of cessation treatments delivered in resource-limited settings. In addition, the findings will be instrumental in identifying specific constructs that should be targeted for intervention and will provide a strong foundation for the development of future cessation interventions targeting smokers living with HIV/AIDS. PMID:24517853

76 FR 81009 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... assessment, planning, forecasting, cost/benefit analysis, and to target areas for research. DATES: Written..., forecasting, cost/benefit analysis, and to target areas for research. Respondents: Approximately 83,500 owners... invites public comments about our intention to request the Office of Management and Budget (OMB) approval...

Nice Thinking! an Educational Intervention That Teaches Children to Think Gratefully

ERIC Educational Resources Information Center

Froh, Jeffrey J.; Bono, Giacomo; Fan, Jinyan; Emmons, Robert A.; Henderson, Katherine; Harris, Cheray; Leggio, Heather; Wood, Alex M.

2014-01-01

Gratitude is essential to social life and well-being. Although research with youth populations has gained momentum recently, only two gratitude interventions have been conducted in youth, targeting mostly adolescents. In the current research, we tested a new intervention for promoting gratitude among the youngest children targeted to date.…

77 FR 45381 - Cash Account Trust, et al.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

..., DWS Market Trust, DWS Money Funds, DWS Money Market Trust, DWS Municipal Trust, DWS Portfolio Trust, DWS Securities Trust, DWS State Tax-Free Income Series, DWS Target Date Series, DWS Target Fund, DWS Tax Free Trust, DWS Value Series, Inc., DWS Variable Series I, DWS Variable Series II, Investors Cash...

76 FR 19173 - Self-Regulatory Organizations; the Options Clearing Corporation; Order Granting Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Lawson, Senior Special Counsel, Division of Trading and Markets (``Division''), Commission, dated May 20... return--of two index components (the target component and the benchmark component). The index is calculated by measuring the total return of the target component relative to the total return of the...

Enhanced Polar System (EPS)

DTIC Science & Technology

2015-12-01

Aug 2014 Aug 2014 Feb 2015 Jul 2014 DT&E Completion for Single String May 2017 May 2017 Nov 2017 May 2017 RAA Jun 2018 Jun 2018 Jun 2019 Jun 2018 Change...as defined by Section 12.0 of the EPS CDD dated September 15, 2011 in support of IOC. RAA is the date two hosted payloads, T&C-T, CAPS, and the Gateway...system with the three NMTs are available for operational use per Section 12.3 of the EPS CDD dated September 15, 2011, in support of FOC. The RAA

Integration of Behavioral Threat Management into Fusion Center Operations to Prevent Mass or Targeted Violence

DTIC Science & Technology

2016-12-01

On Killing: The Psychological Cost of Learning to Kill in War and Society (New York: Integrated Media Incorporated, 2014), Kindle location 2618...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release. Distribution is unlimited. INTEGRATION OF...REPORT DATE December 2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE INTEGRATION OF BEHAVIORAL THREAT MANAGEMENT INTO

Tensor Invariant Processing for Munitions/Clutter Classification

DTIC Science & Technology

2013-11-01

Report," U.S. Naval Research Laboratory Report NRL/MR/ 6110 --12-9401, April 2012. 5. ESTCP Live Site Demonstrations, Former Camp Beale, Marysville, CA ...currently valid OMB control number. 1. REPORT DATE NOV 2013 2 . REPORT TYPE 3. DATES COVERED 00-00-2013 to 00-00-2013 4. TITLE AND SUBTITLE...inversion............................................................. 4 Figure 2 . Multi-coil arrays exciting target with different primary field directions

Prevalence and Correlates of the Perpetration of Cyber Dating Abuse among Early Adolescents.

PubMed

Peskin, Melissa F; Markham, Christine M; Shegog, Ross; Temple, Jeff R; Baumler, Elizabeth R; Addy, Robert C; Hernandez, Belinda; Cuccaro, Paula; Gabay, Efrat K; Thiel, Melanie; Emery, Susan Tortolero

2017-02-01

Much is known about the prevalence and correlates of dating violence, especially the perpetration of physical dating violence, among older adolescents. However, relatively little is known about the prevalence and correlates of the perpetration of cyber dating abuse, particularly among early adolescents. In this study, using a predominantly ethnic-minority sample of sixth graders who reported ever having had a boyfriend/girlfriend (n = 424, 44.2 % female), almost 15 % reported perpetrating cyber dating abuse at least once during their lifetime. Furthermore, using a cross-sectional design, across multiple levels of the socio-ecological model, the individual-level factors of (a) norms for violence for boys against girls, (b) having a current boyfriend/girlfriend, and (c) participation in bullying perpetration were correlates of the perpetration of cyber dating abuse. Collectively, the findings suggest that dating violence interventions targeting these particular correlates in early adolescents are warranted. Future studies are needed to establish causation and to further investigate the relative importance of correlates of the perpetration of cyber dating abuse among early adolescents that have been reported among older adolescents.

76 FR 11681 - Improving Public Safety Communications in the 800 MHz Band; New 800 MHz Band Plan for Puerto Rico...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... Bureau adopted a single 90-day mandatory negotiation period for the remaining incumbent licensees that... the date for completion of mandatory negotiations. However, the freeze does not apply to applications... negotiations. Thirty days before the start date for each NPSPAC region other than Region 47 and Region 48, the...

26. Photocopy of photograph dated 1930; photographer unknown; original filed ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. Photocopy of photograph dated 1930; photographer unknown; original filed as MR2.9/SP8/p343 in Audio-Visual Collection of Minnesota Historical Society, St. Paul; THREE-QUARTER VIEW SHOWING WEST SIDE AND SOUTH FRONT SHORTLY AFTER COMPLETION; LOOKING NORTHEAST - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

Bystander Interventions for Sexual Assault and Dating Violence on College Campuses: Are We Putting Bystanders in Harm's Way?

ERIC Educational Resources Information Center

Witte, Tricia H.; Casper, Deborah M.; Hackman, Christine L.; Mulla, Mazheruddin M.

2017-01-01

Objective: The present study investigated the well-being of bystanders who witness and intervene in sexual assault and dating violence situations on campus. Participants: Participants were 321 young men and women from a large university in the southeastern United States. Methods: Participants completed a survey at the end of the Spring semester of…

17 CFR 240.14a-101 - Schedule 14A. Information required in proxy statement.

Code of Federal Regulations, 2013 CFR

2013-04-01

... regard to any person who held any of the specified positions or relationship at any time during the... General Instruction I.C. of Form S-3 is met. Item 1. Date, time and place information. (a) State the date, time and place of the meeting of security holders, and the complete mailing address, including ZIP Code...

17 CFR 240.14a-101 - Schedule 14A. Information required in proxy statement.

Code of Federal Regulations, 2014 CFR

2014-04-01

... regard to any person who held any of the specified positions or relationship at any time during the... General Instruction I.C. of Form S-3 is met. Item 1. Date, time and place information. (a) State the date, time and place of the meeting of security holders, and the complete mailing address, including ZIP Code...

17 CFR 240.14a-101 - Schedule 14A. Information required in proxy statement.

Code of Federal Regulations, 2012 CFR

2012-04-01

... regard to any person who held any of the specified positions or relationship at any time during the... General Instruction I.C. of Form S-3 is met. Item 1. Date, time and place information. (a) State the date, time and place of the meeting of security holders, and the complete mailing address, including ZIP Code...

12 CFR 225.82 - How does a bank holding company elect to become a financial holding company?

Code of Federal Regulations, 2010 CFR

2010-01-01

... holding company to become a financial holding company shall not be effective if, during the period...) Effective date of election—(1) In general. An election filed by a bank holding company under paragraph (a... financial holding company is effective prior to the 31st day after the date that a complete declaration was...

When the Due Date Is Not the "Do" Date!

ERIC Educational Resources Information Center

Mastrianni, Theresa M.

2015-01-01

Our students consistently hand in assignments late, or complete them at the last minute. Why is it that they know about assignments all term long yet only begin them the night before the assignment is due? Based on a career-focused learning community at Kingsborough Community College of the City University of New York, this article looks at ways…

40 CFR 35.937-9 - Required solicitation and subagreement provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

...; (2) The time for performance and completion of the contract work, including where appropriate, dates for completion of significant project tasks; (3) Personnel and facilities necessary to accomplish the... for later tasks or steps at the time of contract execution, the contract should not include the...

29 CFR 35.31 - Complaints.

Code of Federal Regulations, 2010 CFR

2010-07-01

... behalf of others, may file a complaint with CRC alleging discrimination in violation of the Act or these... complaint is considered to be complete on the date CRC receives all the information necessary to process it, as provided in paragraph (c)(1) of this section. CRC will: (1) Accept as a complete complaint any...

24 CFR 213.256 - Premiums; insurance upon completion.

Code of Federal Regulations, 2010 CFR

2010-04-01

...; insurance upon completion. (a) Management and Sales Types and Investor Sponsored Projects. (1) Where the..., the mortgagee on the date of the first principal payment shall pay a second premium equal to one-half of one percent of the average outstanding principal obligation of the mortgage for the year following...

Targeting MEK5 Enhances Radiosensitivity of Human Prostate Cancer and Impairs Tumor-Associated Angiogenesis

DTIC Science & Technology

2016-09-01

AWARD NUMBER: W81XWH-15-1-0296 TITLE: Targeting MEK5 Enhances Radiosensitivity of Human Prostate Cancer and Impairs Tumor- Associated...3. DATES COVERED 31 Aug 2015 - 30 Aug 2016 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Targeting MEK5 Enhances Radiosensitivity of Human Prostate...therapeutic modality for the treatment of human prostate cancer. However, tumors often demonstrate resistance to ionizing radiation and continue to

Stress and PTSD Mechanisms as Targets for Pharmacotherapy of Alcohol Abuse, Addiction, and Relapse

DTIC Science & Technology

2015-10-01

AWARD NUMBER: W81XWH-13-1-0126 TITLE: Stress and PTSD Mechanisms as Targets for Pharmacotherapy of Alcohol Abuse, Addiction, and Relapse...DATES COVERED 30 Sep 2014 - 29 Sep 2015 4. TITLE AND SUBTITLE Stress and PTSD Mechanisms as Targets for Pharmacotherapy of Alcohol Abuse, Addiction...demonstrated that alcohol -na"ive rats exhibiting high acoustic startle response (which is associated with increased anxiety-like behavior) develop

Global analysis of bacterial transcription factors to predict cellular target processes.

PubMed

Doerks, Tobias; Andrade, Miguel A; Lathe, Warren; von Mering, Christian; Bork, Peer

2004-03-01

Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to comparative genomics approaches. We have applied genome-context methods to predict target processes that are regulated by transcription factors (TFs). Of 128 orthologous groups of proteins annotated as TFs, to date, 36 are functionally uncharacterized; in our analysis we predict a probable cellular target process or biochemical pathway for half of these functionally uncharacterized TFs.

Bullying Predicts Reported Dating Violence and Observed Qualities in Adolescent Dating Relationships.

PubMed

Ellis, Wendy E; Wolfe, David A

2015-10-01

The relationship between reported bullying, reported dating violence, and dating relationship quality measured through couple observations was examined. Given past research demonstrating similarity between peer and dating contexts, we expected that bullying would predict negative dating experiences. Participants with dating experience (n = 585; 238 males, M(age) = 15.06) completed self-report assessments of bullying and dating violence perpetration and victimization. One month later, 44 opposite-sex dyads (M(age) = 15.19) participated in behavioral observations. In 10-min sessions, couples were asked to rank and discuss areas of relationship conflict while being video-recorded. Qualities of the relationship were later coded by trained observers. Regression analysis revealed that bullying positively predicted dating violence perpetration and victimization. Self-reported bullying also predicted observations of lower relationship support and higher withdrawal. Age and gender interactions further qualified these findings. The bullying of boys, but not girls, was significantly related to dating violence perpetration. Age interactions showed that bullying was positively predictive of dating violence perpetration and victimization for older, but not younger adolescents. Positive affect was also negatively predicted by bullying, but only for girls. These findings add to the growing body of evidence that adolescents carry forward strategies learned in the peer context to their dating relationships. © The Author(s) 2014.

Prevalence of teen dating victimization among a representative sample of high school students in Quebec.

PubMed

Hébert, Martine; Blais, Martin; Lavoie, Francine

2017-01-01

The present study aimed to (1) examine prevalence rates and frequency of dating violence victimization among a representative sample of Quebec high school adolescents and (2) explore possible gender differences in these rates as well as in perceived impact of victimization. A sample of 8,194 students completed questionnaires evaluating dating victimization in the past 12 months as well as perceived impacts. Results show that psychological violence is the most frequent form of dating victimization reported. Girls are more likely to report experiences of psychological, physical, threatening behaviors as well as sexual dating victimization than boys. Analyses on different indicators of the impact of victimization (i.e. feelings of fear, distress and post-traumatic stress symptoms) reveal that teenage girls are more vulnerable to sustaining more pervasive impacts than boys. The findings underscore dating violence as a prevalent public health problem. A significant number of teens report dating victimization with girls more likely than boys to perceive negative impacts associated with the coercive behaviors experienced.

Consequences of Dating for Post-Divorce Maternal Well-Being

PubMed Central

Langlais, Michael R.; Anderson, Edward R.; Greene, Shannon M.

2016-01-01

Repartnering has been linked to health benefits for mothers, yet few studies have examined relationship quality in this context. According to the divorce-stress-adaptation perspective, relationship quality may influence the relationship between maternal well-being and dating after divorce. The current study examines the consequences of dating, relationship quality, and dating transitions (breaking up and dating new partners) on maternal well-being (negative affect and life satisfaction). Using monthly surveys completed by mothers over a two-year period after filing for divorce, we examined changes in intercepts and slopes of dating status and transitions for maternal well-being while also testing the effects of relationship quality. Mothers entering high-quality relationships were likely to report boosts in well-being at relationship initiation compared to single mothers and mothers entering low-quality relationships. Mothers entering lower-quality relationships were likely to report lower levels of well-being than single mothers. Dating transitions were associated with increases in well-being. Implications for maternal adjustment are discussed. PMID:27746511

Calpains: Potential Targets for Alternative Chemotherapeutic Intervention Against Human Pathogenic Trypanosomatids

PubMed Central

M.H, Branquinha; F.A, Marinho; L.S, Sangenito; S.S.C, Oliveira; K.C, Gonçalves; V, Ennes-Vidal; C.M, d’Avila-Levy; A.L.S, Santos

2013-01-01

The treatment for both leishmaniasis and trypanosomiasis, which are severe human infections caused by trypanosomatids belonging to Leishmania and Trypanosoma genera, respectively, is extremely limited because of concerns of toxicity and efficacy with the available anti-protozoan drugs, as well as the emergence of drug resistance. Consequently, the urgency for the discovery of new trypanosomatid targets and novel bioactive compounds is particularly necessary. In this context, the investigation of changes in parasite gene expression between drug resistant/sensitive strains and in the up-regulation of virulence-related genes in infective forms has brought to the fore the involvement of calpain-like proteins in several crucial pathophysiological processes performed by trypanosomatids. These studies were encouraged by the publication of the complete genome sequences of three human pathogenic trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, which allowed in silico analyses that in turn directed the identification of numerous genes with interesting chemotherapeutic characteristics, including a large family of calpain-related proteins, in which to date 23 genes were assigned as calpains in T. brucei, 40 in T. cruzi and 33 in L. braziliensis. In the present review, we intend to add to these biochemical/biological reports the investigations performed upon the inhibitory capability of calpain inhibitors against human pathogenic trypanosomatids. PMID:23899207

A genetic method for sex determination in Ovis spp. by interruption of the zinc finger protein, Y-linked (ZFY) gene on the Y chromosome.

PubMed

Zhang, Yong Sheng; Du, Ying Chun; Sun, Li Rong; Wang, Xu Hai; Liu, Shuai Bing; Xi, Ji Feng; Li, Chao Cheng; Ying, Rui Wen; Jiang, Song; Wang, Xiang Zu; Shen, Hong; Jia, Bin

2018-03-06

The mammalian Y chromosome plays a critical role in spermatogenesis. However, the exact functions of each gene on the Y chromosome have not been completely elucidated, due, in part, to difficulties in gene targeting analysis of the Y chromosome. The zinc finger protein, Y-linked (ZFY) gene was first proposed to be a sex determination factor, although its function in spermatogenesis has recently been elucidated. Nevertheless, ZFY gene targeting analysis has not been performed to date. In the present study, RNA interference (RNAi) was used to generate ZFY-interrupted Hu sheep by injecting short hairpin RNA (shRNA) into round spermatids. The resulting spermatozoa exhibited abnormal sperm morphology, including spermatozoa without tails and others with head and tail abnormalities. Quantitative real-time polymerase chain reaction analysis showed that ZFY mRNA expression was decreased significantly in Hu sheep with interrupted ZFY compared with wild-type Hu sheep. The sex ratio of lambs also exhibited a bias towards females. Together, the experimental strategy and findings of the present study reveal that ZFY also functions in spermatogenesis in Hu sheep and facilitate the use of RNAi in the control of sex in Hu sheep.

JASMINE: constructor of the dynamical structure of the Galactic bulge

NASA Astrophysics Data System (ADS)

Gouda, N.; Kobayashi, Y.; Yamada, Y.; Yano, T.; Tsujimoto, T.; Suganuma, M.; Niwa, Y.; Yamauchi, M.

2008-07-01

We introduce a Japanese space astrometry project which is called JASMINE. JASMINE (Japan Astrometry Satellite Mission for INfrared Exploration) will measure distances and tangential motions of stars in the Galactic bulge with yet unprecedented precision. JASMINE will operate in z-band whose central wavelength is 0.9 micron. It will measure parallaxes, positions with accuracy of about 10 micro-arcsec and proper motions with accuracy of about 10 micro- arcsec/year for the stars brighter than z=14 mag. The number of stars observed by JASMINE with high accuracy of parallaxes in the Galactic bulge is much larger than that observed in other space astrometry projects operating in optical bands. With the completely new “map of the Galactic bulge” including motions of bulge stars, we expect that many new exciting scientific results will be obtained in studies of the Galactic bulge. One of them is the construction of the dynamical structure of the Galactic bulge. Kinematics and distance data given by JASMINE are the closest approach to a view of the exact dynamical structure of the Galactic bulge. Presently, JASMINE is in a development phase, with a target launch date around 2016. We comment on the outline of JASMINE mission, scientific targets and a preliminary design of JASMINE in this paper.

Brain communication in the locked-in state.

PubMed

De Massari, Daniele; Ruf, Carolin A; Furdea, Adrian; Matuz, Tamara; van der Heiden, Linda; Halder, Sebastian; Silvoni, Stefano; Birbaumer, Niels

2013-06-01

Patients in the completely locked-in state have no means of communication and they represent the target population for brain-computer interface research in the last 15 years. Although different paradigms have been tested and different physiological signals used, to date no sufficiently documented completely locked-in state patient was able to control a brain-computer interface over an extended time period. We introduce Pavlovian semantic conditioning to enable basic communication in completely locked-in state. This novel paradigm is based on semantic conditioning for online classification of neuroelectric or any other physiological signals to discriminate between covert (cognitive) 'yes' and 'no' responses. The paradigm comprised the presentation of affirmative and negative statements used as conditioned stimuli, while the unconditioned stimulus consisted of electrical stimulation of the skin paired with affirmative statements. Three patients with advanced amyotrophic lateral sclerosis participated over an extended time period, one of which was in a completely locked-in state, the other two in the locked-in state. The patients' level of vigilance was assessed through auditory oddball procedures to study the correlation between vigilance level and the classifier's performance. The average online classification accuracies of slow cortical components of electroencephalographic signals were around chance level for all the patients. The use of a non-linear classifier in the offline classification procedure resulted in a substantial improvement of the accuracy in one locked-in state patient achieving 70% correct classification. A reliable level of performance in the completely locked-in state patient was not achieved uniformly throughout the 37 sessions despite intact cognitive processing capacity, but in some sessions communication accuracies up to 70% were achieved. Paradigm modifications are proposed. Rapid drop of vigilance was detected suggesting attentional variations or variations of circadian period as important factors in brain-computer interface communication with locked-in state and completely locked-in state.

Quick Reaction Report on DoD Procurements Through the Tennessee Valley Authority

DTIC Science & Technology

1992-04-03

from non-DoD agencies that includes sections to be completed and signed by a contracting officer. Recommendations for Corrective Actions We recommend...in the DD 350 Individual Contract Action Reporting System. The Assistant Secretary did not provide planned dates for completing the corrective actions ...will be reprocured. Tentative milestones for completion of the corrective actions were not identified. Defense Logistics Agency comments. The Deputy

Pupillometry and Saccades as Objective mTBI Biomarker

DTIC Science & Technology

2016-10-01

INTRODUCTION: The DOD reported that 333,169 cases of traumatic brain injury (TBI) were confirmed since 2000, with mild TBI (mTBI) accounting for 82.4...Complete final report: NO INITIATED (A 6-month No Cost Extension was approved to complete data analysis and manuscript writing.) KEY RESEARCH...Staff hiring issues delayed study completion; however a 6-month No Cost extension was approved Budget Expenditure to Date Projected Expenditure

Novel strategy for a bispecific antibody: induction of dual target internalization and degradation.

PubMed

Lee, J M; Lee, S H; Hwang, J-W; Oh, S J; Kim, B; Jung, S; Shim, S-H; Lin, P W; Lee, S B; Cho, M-Y; Koh, Y J; Kim, S Y; Ahn, S; Lee, J; Kim, K-M; Cheong, K H; Choi, J; Kim, K-A

2016-08-25

Activation of the extensive cross-talk among the receptor tyrosine kinases (RTKs), particularly ErbB family-Met cross-talk, has emerged as a likely source of drug resistance. Notwithstanding brilliant successes were attained while using small-molecule inhibitors or antibody therapeutics against specific RTKs in multiple cancers over recent decades, a high recurrence rate remains unsolved in patients treated with these targeted inhibitors. It is well aligned with multifaceted properties of cancer and cross-talk and convergence of signaling pathways of RTKs. Thereby many therapeutic interventions have been actively developed to overcome inherent or acquired resistance. To date, no bispecific antibody (BsAb) showed complete depletion of dual RTKs from the plasma membrane and efficient dual degradation. In this manuscript, we report the first findings of a target-specific dual internalization and degradation of membrane RTKs induced by designed BsAbs based on the internalizing monoclonal antibodies and the therapeutic values of these BsAbs. Leveraging the anti-Met mAb able to internalize and degrade by a unique mechanism, we generated the BsAbs for Met/epidermal growth factor receptor (EGFR) and Met/HER2 to induce an efficient EGFR or HER2 internalization and degradation in the presence of Met that is frequently overexpressed in the invasive tumors and involved in the resistance against EGFR- or HER2-targeted therapies. We found that Met/EGFR BsAb ME22S induces dissociation of the Met-EGFR complex from Hsp90, followed by significant degradation of Met and EGFR. By employing patient-derived tumor models we demonstrate therapeutic potential of the BsAb-mediated dual degradation in various cancers.

Ada Compiler Validation Summary Report: Certificate Number 891201S1. 10214 U.S. Navy Ada/M, Version 2.0 (/OPTIMIZE Option) VAX 8550 and VAX 11/785 Hosts AN/UYK-44 Target

DTIC Science & Technology

1989-12-01

s -M-COM ST-1815A, Ada Joint Program Office 17.gbJftYCLSSF~ATW4 Is. SECURITY CLASSFAT04 OAS. TRUmVACAT M. LUITAf WCOF ABSTRACT Xi LLASSIFIED I CM ...Department of Defense Dist Specla Washington DC 20301 AVF Control Number: NIST89USN5556_1. 10 DATE VSR CPIEM BEFORE ON-SITE: 08-11-89 DATE VSR C34PLETED AFTER...ON-SITE: 12-04-89 DATE VSR MODIFIED PER AVO C31ME : 12-29-89 DATE VSR MODIFIED PER AVO CMtEN: 04-27-90 Ada O4PIIER VALIDATION SUM4M REPORT

KSC-08pd3156

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ Hubble Space Telescope payload inside heads for the open doors of the Canister Rotation Facility. The payload comprises four carriers holding various equipment for the mission. After rotation to horizontal, the canister will be transported back to Kennedy’s Payload Hazardous Servicing Facility where the hardware will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope Photo credit: NASA/Tim Jacobs

KSC-08pd3196

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the doors of the payload canister are opened inside a clean room of the Payload Hazardous Servicing Facility, or PHSF. The canister contains the Hubble Space Telescope equipment. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3195

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the doors of the payload canister are opened inside a clean room of the Payload Hazardous Servicing Facility, or PHSF. The canister contains the Hubble Space Telescope equipment. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3157

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ Hubble Space Telescope payload inside roll through the open doors of the Canister Rotation Facility. The payload comprises four carriers holding various equipment for the mission. After rotation to horizontal, the canister will be transported back to Kennedy’s Payload Hazardous Servicing Facility where the hardware will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope Photo credit: NASA/Tim Jacobs

KSC-08pd3186

NASA Image and Video Library

2008-10-14

CAPE CANAVERAL, Fla. – As the sunset faces behind Launch Pad 39A at NASA's Kennedy Space Center in Florida, lights on the rotating and fixed service structures take over the luminescence in the night. Space shuttle Atlantis is on the pad. Atlantis’ October target launch date for the STS-125 Hubble Space Telescope servicing mission was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. In the interim, Atlantis will be rolled back to the Vehicle Assembly Building until a new target launch date can be set for the mission in 2009. Photo credit: NASA/Troy Cryder

KSC-08pd3155

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ Hubble Space Telescope payload inside heads toward the Canister Rotation Facility. The payload comprises four carriers holding various equipment for the mission. After rotation to horizontal, the canister will be transported back to Kennedy’s Payload Hazardous Servicing Facility where the hardware will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope Photo credit: NASA/Tim Jacobs

KSC-08pd3153

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ Hubble Space Telescope payload inside makes its way to the Canister Rotation Facility. The payload comprises four carriers holding various equipment for the mission. After rotation to horizontal, the canister will be transported back to Kennedy’s Payload Hazardous Servicing Facility where the hardware will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope Photo credit: NASA/Tim Jacobs

KSC-08pd3132

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ HST payload inside makes the turn past the Vehicle Assembly Building onto Kennedy Parkway. The payload comprises four carriers holding various equipment for the mission. The hardware will be transported back to Kennedy’s Payload Hazardous Servicing Facility where it will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Tim Jacobs

KSC-08pd3158

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ Hubble Space Telescope payload arrives inside the Canister Rotation Facility. The payload comprises four carriers holding various equipment for the mission. After rotation to horizontal, the canister will be transported back to Kennedy’s Payload Hazardous Servicing Facility where the hardware will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope Photo credit: NASA/Tim Jacobs

KSC-08pd3182

NASA Image and Video Library

2008-10-14

CAPE CANAVERAL, Fla. – On Launch Pad 39A at NASA's Kennedy Space Center in Florida, the rising moon stands out alongside the rotating and fixed service structures around space shuttle Atlantis. At left is the 300,000-gallon water tower used for sound suppression during liftoffs. Atlantis’ October target launch date for the STS-125 Hubble Space Telescope servicing mission was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. In the interim, Atlantis will be rolled back to the Vehicle Assembly Building until a new target launch date can be set for the mission in 2009. Photo credit: NASA/Troy Cryder

KSC-08pd3129

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ HST payload inside rolls past the Vehicle Assembly Building and Launch Control Center, at left. The payload comprises four carriers holding various equipment for the mission. The hardware will be transported back to Kennedy’s Payload Hazardous Servicing Facility where it will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Jim Grossmann

KSC-08pd3194

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, workers in a clean room of the Payload Hazardous Servicing Facility, or PHSF, check the controls on the payload canister with the Hubble Space Telescope equipment inside. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

KSC-08pd3130

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ HST payload inside rolls past the Vehicle Assembly Building and Launch Control Center, behind it. The payload comprises four carriers holding various equipment for the mission. The hardware will be transported back to Kennedy’s Payload Hazardous Servicing Facility where it will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Jim Grossmann

KSC-08pd3154

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ Hubble Space Telescope payload inside heads toward the Canister Rotation Facility. The payload comprises four carriers holding various equipment for the mission. After rotation to horizontal, the canister will be transported back to Kennedy’s Payload Hazardous Servicing Facility where the hardware will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope Photo credit: NASA/Tim Jacobs

KSC-08pd3152

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – On NASA's Kennedy Space Center in Florida, the canister with space shuttle Atlantis’ Hubble Space Telescope payload inside makes its way to the Canister Rotation Facility. The payload comprises four carriers holding various equipment for the mission. After rotation to horizontal, the canister will be transported back to Kennedy’s Payload Hazardous Servicing Facility where the hardware will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope Photo credit: NASA/Tim Jacobs

KSC-08pd3237

NASA Image and Video Library

2008-10-16

CAPE CANAVERAL, Fla. - In the Payload Hazardous Servicing Facility, or PHSF, at NASA's Kennedy Space Center in Florida, the Super Lightweight Interchangeable Carrier, or SLIC, is placed on a work platform after its return to the clean room from Launch Pad 39A. The payload for Hubble servicing mission 4 comprises four carriers holding various equipment for the mission. In the PHSF, the carriers will be stored until a new target launch date in 2009 can be set for Atlantis’ STS-125 mission. Atlantis’ October target launch date was delayed after a device on board Hubble, used in the storage and transmission of science data to Earth, shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Jim Grossmann

KSC-08pd3187

NASA Image and Video Library

2008-10-15

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center in Florida, the payload canister with the Hubble Space Telescope equipment leaves the Canister Rotation Facility to head for the Payload Hazardous Servicing Facility, or PHSF. The payload comprises four carriers holding various equipment for the mission. The canister maintains a controlled environment. In the PHSF, the carriers will be stored until a new target launch date can be set for Atlantis’ STS-125 mission in 2009. Atlantis’ October target launch date was delayed after a device on board Hubble used in the storage and transmission of science data to Earth shut down on Sept. 27. Replacing the broken device will be added to Atlantis’ servicing mission to the telescope. Photo credit: NASA/Troy Cryder

The 6dF Galaxy Survey: First Data Release

NASA Astrophysics Data System (ADS)

Jones, H.; Saunders, W.; Colless, M.; Read, M.; Parker, Q.; Watson, F.; Campbell, L.

2005-06-01

The 6dF Galaxy Survey (6dFGS) is currently measuring the redshifts of around 170 000 galaxies and the peculiar velocities of a 15 000-member sub-sample. It will be the largest redshift survey of the local universe and more than an order of magnitude larger than any peculiar velocity survey to date. When complete, it will cover essentially the entire southern sky around a mean redshift of z = 0.05. Central to the survey is the Six-Degree Field (6dF) multi-fibre spectrograph, an instrument able to record 150 simultaneous spectra over the 5.7°-field of the UK Schmidt Telescope. Targets have been drawn from the 2MASS Extended Source Catalog (XSC) to include all galaxies brighter than Ktot = 12.75, supplemented by 2MASS and SuperCOSMOS galaxies that complete the sample to limits of (H, J, rF, bJ) = (13.05, 13.75, 15.6, 16.75). Here we describe the implementation of the survey and the procedures used to select sources and determine redshifts. We also describe early results utilising the First Data Release of ˜ 45 000 redshifts. There is an online database of 6dFGS data accessible from the 6dFGS web site (http://www.mso.anu.edu.au/6dFGS).

Metabolome based volatiles profiling in 13 date palm fruit varieties from Egypt via SPME GC-MS and chemometrics.

PubMed

Khalil, Mohammed N A; Fekry, Mostafa I; Farag, Mohamed A

2017-02-15

Dates (Phoenix dactylifera L.) are distributed worldwide as major food complement providing a source of sugars and dietary fiber as well as macro- and micronutrients. Although phytochemical analyses of date fruit non-volatile metabolites have been reported, much less is known about the aroma given off by the fruit, which is critical for dissecting sensory properties and quality traits. Volatile constituents from 13 date varieties grown in Egypt were profiled using SPME-GCMS coupled to multivariate data analysis to explore date fruit aroma composition and investigate potential future uses by food industry. A total of 89 volatiles were identified where lipid-derived volatiles and phenylpropanoid derivatives were the major components of date fruit aroma. Multivariate data analyses revealed that 2,3-butanediol, hexanal, hexanol and cinnamaldehyde contributed the most to classification of different varieties. This study provides the most complete map of volatiles in Egyptian date fruit, with Siwi and Sheshi varieties exhibiting the most distinct aroma among studied date varieties. Copyright © 2016 Elsevier Ltd. All rights reserved.

Reporting bias in completed epilepsy intervention trials: A cross-sectional analysis.

PubMed

Rayi, Appaji; Thompson, Stephanie; Gloss, David; Malhotra, Konark

2018-03-30

To explore the evidence of reporting bias among completed epilepsy intervention trials (EITs) and compliance of applicable EITs to Food and Drug Administration Amendments Act (FDAAA). We included consecutive EITs registered as completed on ClinicalTrials.gov from 2008 to 2015. Descriptive data was collected including study type, study phase, funding source, primary completion date, and result reporting date. Time to result reporting was analyzed using Kaplan-Meier estimates for two time periods (2008-2011 and 2012-2015). PubMed, Web of Science, and Google scholar databases were manually searched for publication details. Overall, 95/126 EITs (75%) reported, while remaining 31/126 (25%) did not report their results. Time to reporting was significantly lower for trials completed during 2012-2015 (16.5 months; 95% CI: 13.60-19.40; p = .002; Cohen's d = 0.68) as compared to the trials completed during 2008-2011 (25.9 months; 95% CI: 21.56-30.22). 72/126 trials were conducted in at least one U.S. center. 56/72 (78%) of the trials met the FDAAA criteria, while only 19/56 (34%) reported within the mandated one-year time frame. The lack of reporting of nearly one-quarter of completed epilepsy intervention trials suggests existence of reporting bias. As such, it should be considered an important criterion for determining risk of bias in epilepsy systematic reviews. Copyright © 2018 Elsevier B.V. All rights reserved.

77 FR 38347 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... Component of the Alpha Pair. To calculate the daily total return today of a Target Component or a Benchmark... Benchmark Component, respectively, would be subtracted from today's closing market price for the Target...''). The Price Difference would be added to any declared dividend, if today were an ``ex-dividend'' date...

Intern Programs | Key Dates

Science.gov Websites

Application Deadline Program Dates CCI October 16, 2017 January 12, 2018 June 4–August 10, 2018 GEM –August 31, 2018 Lee Teng November 2017 January 22, 2018 May 29–August 10, 2018 QuarkNet March 19, 2018 –August 10, 2018 SULI October 16, 2017 January 12, 2018 June 4–August 10, 2018 TARGET December 18, 2017

SWIR Sky Glow Imaging for Detection of Turbulence in the Upper Atmosphere: Postprint

DTIC Science & Technology

2010-01-01

TP-2010-1015 SWIR SKY GLOW IMAGING FOR DETECTION OF TURBULENCE IN THE UPPER... the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this...number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 01-01-2010 2. REPORT TYPE Technical Paper 3. DATES COVERED

Listing of awardee names: Active awards as of October 5, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-10-05

This is a listing of awarded active contracts for all US DOE facilities and projects. The information contained in the list includes the awardee name and division responsible for the work, BIN, completion date, a one line description of the work, the vendor ID, city, state, congressional district, the value of the contract and the amount of funds expended to date.

Report of the Military Compensation and Retirement Modernization Commission

DTIC Science & Technology

2015-01-29

instructions , searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information ...collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 29 JAN 2015 2. REPORT TYPE Final 3. DATES...42  Recommendation 3: Promote Service members’ financial literacy by implementing a more robust financial and health benefit training program

Roswell Park Cancer Institute/ Howard University Prostate Cancer Scholars Program

DTIC Science & Technology

2016-10-01

INVESTIGATOR: Wendy Huss, PhD CONTRACTING ORGANIZATION : Health Research , Inc. Buffalo, NY 14263-0001 REPORT DATE: October 2016 TYPE OF REPORT: Annual...RHPCS Program to encourage interns to enter graduate training and careers in prostate cancer research . Completion dates for activities and progress on... interns to enter graduate training and careers in prostate cancer research . SOW-Major Task 4: Track Prostate Cancer Scholar professional activities

District Awards for Teacher Excellence (D.A.T.E.) Program: Year One Evaluation Report. Policy Evaluation Report. [Executive Summary

ERIC Educational Resources Information Center

Springer, Matthew G.; Lewis, Jessica L.; Podgursky, Michael J.; Ehlert, Mark W.; Taylor, Lori L.; Lopez, Omar S.; Ghoshdastidar, Bonnie; Peng, Art

2010-01-01

The District Awards for Teacher Excellence's (D.A.T.E.'s) first year of implementation in 2008-09 occurred at a time when Texas was operating several state-funded performance pay programs. The three-year Governor's Educator Excellence Grant (G.E.E.G.) program was coming to its expected completion, while the Texas Educator Excellence Grant…

Therapeutic Targeting of TRPV1 for the Treatment of Chronic Pain Associated with Prostate Cancer Bone Metastasis

DTIC Science & Technology

2012-07-01

1 AD_________________ Award Number: W81XWH-11-1-0333 TITLE: Therapeutic Targeting of TRPV1 for the...01-07-2012 2. REPORT TYPE Annual 3. DATES COVERED 1 July 2011 to 30 June 2012 4. TITLE AND SUBTITLE Therapeutic Targeting of TRPV1 for the...specific inflammatory factors, IL-6 and TNF-α, PTHrP and ET-1 on upregulation of TRPV1 channel function/expression, and nociceptor sensitization

Invasive Species Science Update (No. 6)

Treesearch

Paula Fornwalt

2013-01-01

The sixth issue of the Rocky Mountain Research Station's (RMRS) Invasive Species Science Update is now complete. Published approximately once per year, this newsletter keeps managers and other users up-to-date with recently completed and ongoing research by RMRS scientists, and covers breaking news related to invasive species issues. The newsletter is produced by...

26 CFR 1.410(a)-3 - Minimum age and service conditions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... age and service conditions. (a) General rule. Except as provided by paragraph (b) or (c) of this... which the employee completes 1 year of service. (b) Special rule for plan with 3-year 100 percent... of service. The date on which the employee completes 3 years of service. (c) Special rule for...

78 FR 26382 - Advisory Committee on Commercial Operations of Customs and Border Protection (COAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

... Completed by the Export Mapping Working Group (EMWG) to date. 3. Review and Discuss the Global Supply Chain Subcommittee's Air Cargo Advance Screening (ACAS) Working Group and address Next Steps regarding Land Border... the Trusted Trader Subcommittee and the Work Completed by the Industry Standards Working Group (ISWG...

76 FR 75907 - Notice of Inventory Completion: Minnesota Indian Affairs Council, Bemidji, MN

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

...''). History and Description of the Remains At an unknown date, human remains representing, at minimum, two.... SUMMARY: The Minnesota Indian Affairs Council has completed an inventory of human remains and associated... tribe that believes itself to be culturally affiliated with the human remains may contact the Minnesota...

ADM. Change House (TAN606) as completed. Camera facing northerly. Note ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ADM. Change House (TAN-606) as completed. Camera facing northerly. Note proximity to shielding berm. Part of hot shop (A&M Building, TAN-607) at left of view beyond berm. Date: October 29, 1954. INEEL negative no. 12705 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

75 FR 8724 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... complete the Completion Survey. Therefore, over three years we will recruit 1800 students (300 per year... Dating Violence among At-Risk Middle and High School Students--New--National Center for Injury Prevention... middle and high school students supported by ERSG, compared to at-risk students in control schools who do...

7 CFR 654.14 - Duration of sponsor(s)' responsibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... performed by force account, division of work, or performance of work methods, the sponsor(s)' O&M responsibilities begin on the date the work or portion thereof is completed as determined by NRCS, except for completed work located on Federal lands which are subject to special-use permits. The O&M agreement shall...

Perpetration of Adolescent Dating Relationship Abuse: The Role of Conditional Tolerance for Violence and Friendship Factors.

PubMed

Mumford, Elizabeth A; Taylor, Bruce G; Giordano, Peggy C

2017-02-01

Research has pointed to the salience of friendships in predicting abuse in adolescent dating relationships. The current study investigates the perpetration of physical and sexual dating abuse as predicted by individual conditional tolerance for dating abuse within the context of friendship behaviors and group characteristics. Using two waves of the National Survey of Teen Relationships and Intimate Violence (STRiV; N = 511 daters aged 12-18 years), we investigated the effects of baseline individual tolerance for hitting dating partners and friendship factors on perpetration of physical and sexual adolescent dating abuse (ADA) approximately 1 year later. Conditional tolerance for hitting boyfriends was associated with ADA perpetration in the absence of friendship characteristics. Daters who reported recent discussion of a problem with friends and female daters who named all-girl friendship groups were more likely to report ADA perpetration. Close friendships are an avenue for preventing ADA perpetration. Furthermore, ADA perpetration may be reduced by targeting conditional tolerance for violence particularly against male partners within female friendship groups.

Comprehensive Molecular Characterization of Urothelial Bladder Carcinoma

PubMed Central

2014-01-01

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. To date, no molecularly targeted agents have been approved for the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 urothelial carcinomas to provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved in cell cycle regulation, chromatin regulation, and kinase signaling pathways, as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes, two of which (papillary-like and basal/squamous-like) were also evident in miRNA sequencing and protein data. Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation. Our analyses identified potential therapeutic targets in 69% of the tumours, including 42% with targets in the PI3K/AKT/mTOR pathway and 45% with targets (including ERBB2) in the RTK/MAPK pathway. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any common cancer studied to date, suggesting the future possibility of targeted therapy for chromatin abnormalities. PMID:24476821

Extracting Date/Time Expressions in Super-Function Based Japanese-English Machine Translation

NASA Astrophysics Data System (ADS)

Sasayama, Manabu; Kuroiwa, Shingo; Ren, Fuji

Super-Function Based Machine Translation(SFBMT) which is a type of Example-Based Machine Translation has a feature which makes it possible to expand the coverage of examples by changing nouns into variables, however, there were problems extracting entire date/time expressions containing parts-of-speech other than nouns, because only nouns/numbers were changed into variables. We describe a method for extracting date/time expressions for SFBMT. SFBMT uses noun determination rules to extract nouns and a bilingual dictionary to obtain correspondence of the extracted nouns between the source and the target languages. In this method, we add a rule to extract date/time expressions and then extract date/time expressions from a Japanese-English bilingual corpus. The evaluation results shows that the precision of this method for Japanese sentences is 96.7%, with a recall of 98.2% and the precision for English sentences is 94.7%, with a recall of 92.7%.

Developing Zircon as a Probe of Planetary Impact History

NASA Astrophysics Data System (ADS)

Wielicki, Matthew

2014-12-01

The identification of Meteor Crater in Arizona as an extraterrestrial impact by Eugene Shoemaker provided the first evidence of this geologic phenomenon and opened the door to a new field of research that has eventually lead to the identification of over ~150 terrestrial impact structures. Subsequently impacts have been evoked in the formation of the moon, delivery of volatiles and bio-precursors to early Earth, creation of habitats for the earliest life and, in more recent times, major mass extinction events. However, understanding the impact flux to the Earth-Moon system has been complicated by the constant weathering and erosion at Earth's surface and the complex nature of impactite samples such that only a hand full of terrestrial craters have been accurately and precisely dated. Currently 40Ar/39Ar step-heating analysis of impactite samples is commonly used to infer impact ages but can be problematic due to the presence of relic clasts, incomplete 40Ar outgassing or excess 40Ar, and recoil and shock effects. The work presented here attempts to develop zircon geochronology to probe planetary impact histories as an alternative to current methods and provides another tool by which to constrain the bolide flux to the Earth-Moon system. Zircon has become the premier geo-chronometer in earth science and geochemical investigation of Hadean zircon from Western Australia has challenged the long-standing, popular conception that the near-surface Hadean Earth was an uninhabitable and hellish world; Zircons may preserve environmental information regarding their formation and thus provide a rare window into conditions on early Earth. Isotopic and petrologic analyses of these ancient grains have been interpreted to suggest that early Earth was more habitable than previously envisioned, with water oceans, continental crust, and possibly even plate tectonics. The Hadean is also suspected to be a time of major planetary bombardment however identifying impact signatures within the Hadean population remains difficult and this study hopes to develop criteria to recognize impact zircon and possibly provide constraints on the early impactor flux. Five large terrestrial craters, Vredefort and Morokweng, South Africa, Sudbury and Manicouagan, Canada, and Popigai, Russia, are the focus of this study as smaller craters do not have the energy to produce thick melt sheets, which persist over time-scales sufficient for crystallization of zircon, permitting geochemical and geochronological analysis. Geochemical analysis of these impact-produced zircons yields similar chemical signatures to endogenic igneous zircon from crustal melts and highlights the need for well-developed criteria for discriminating impact and endogenic grains for impact geochronology. One such criterion is modeling of impact zircon crystallization temperature spectra for simulated impact events on targets of varying composition. Provided some assumptions the zircon crystallization spectra can be estimated from well established Zr systematics in crustal melts. Results for impacts into an Archean terrestrial surface (used as a proxy for the Hadean as little to no rock record exists >4.0 Ga) yields a crystallization spectra significantly higher than that reported for the Hadean zircon population and appears to rule out impacts as a dominant source for these ancient grains. When no dateable impact melt sheet exists, either due to the lack of energy of the impact itself or from subsequent erosion at Earth's surface, loss of radiogenic lead, Pb*, has been suggested as an alternative method to date the event. Pb*-loss was investigated from target rocks from Vredefort and Morokweng and suggests that Pb* diffusion, even in zircon isolated from shocked and brecciated target rocks, is remarkably slow. This may explain the seeming lack of 'reset' zircon in terrestrial impactites. Little is known about Pb* diffusion pathways associated with shock microstructures introduced during impact cratering and future diffusion studies may provide better constraints on this problem. Although little disturbance was identified in Pb* of target zircon, other low temperature geochronometers, zircon (U-Th)/He dating in this case, have been shown to be completely 'reset' and accurately date impacts. Zircon (U-Th)/He ages isolated from the target rock below ~850 m of well-dated impact melt at Morokweng yield ages consistent with the impact melt sheet and provide an alternative tool to dating events where such melts no longer exists. This geochronometer was also applied to impactites from Popigai, Russia and results in an age that is significantly younger than that reported in the literature and coincident with the Eocene-Oligocene boundary mass extinction event however the lack of any impact signatures at this boundary is puzzling. Constraining the impact flux to the Earth-Moon system not only allows for a better understanding into early Earth evolution and the formation of a habitable planet but also provides constraints on the modern impactor flux, important criteria for estimating the likelihood of future impact events. Zircon geochronology offers an exciting new tool by which to date impact events and has the potential to assist understanding of complex impactite samples from terrestrial craters and future sample return missions.

Elemental analysis using ED-XRF and 14C dating of Cuman wall paintings samples

NASA Astrophysics Data System (ADS)

Brocchieri, J.; Sabbarese, C.; Marzaioli, F.; Passariello, I.; Terrasi, F.; De Maio, C.; Ferrara, L.

2018-04-01

The aim of the present research was to analyse pigments and mortars of fresco fragments located at Cuma (Naples, Italy). The ED-XRF technique and 14C dating were used to establish the nature of the pigments and the age of mortars, respectively. ED-XRF results allowed to determine the elemental composition of the pigments that identified the colours and, hence, the historical period of completion. The 14C dating, applied to mortars using a particular preparation, provided results that are in accordance with the archaeological information within the 2σ interval range.

A Gas-Actuated Projectile Launcher for High-Energy Impact Testing of Structures

NASA Technical Reports Server (NTRS)

Ambur, Damodar R.; Jaunky, Navin; Lawson, Robin E.; Knight, Norman F., Jr.; Lyle, Karen H.

1999-01-01

A gas-act,uated penetration device has been developed for high-energy impact testing of structures. The high-energy impact. t,estiiig is for experimental simulation of uncontained engine failures. The non-linear transient finite element, code LS-DYNA3D has been used in the numerical simula.tions of a titanium rectangular blade with a.n aluminum target, plate. Threshold velocities for different combinations of pitch and yaw angles of the impactor were obtained for the impactor-target, t8est configuration in the numerica.1 simulations. Complet,e penet,ration of the target plate was also simulat,ed numerically. Finally, limited comparison of analytical and experimental results is presented for complete penetration of the target by the impactor.

Systematic Review of Cyberbullying Interventions for Youth and Parents With Implications for Evidence-Based Practice.

PubMed

Hutson, Elizabeth; Kelly, Stephanie; Militello, Lisa K

2018-02-01

Cyberbullying is a new risk factor for the well-being of pediatric populations. Consequences of cyberbullying include both physical and mental health concerns such as depression, anxiety, and somatic concerns. Adolescents who have been victims of cyberbullying and developed secondary symptoms are often recommended to visit a healthcare provider to obtain effective, evidence-based treatment. To date, no interventions exist in the healthcare setting for adolescents who are victims of cyberbullying. The purpose of this project is to review interventional studies on cyberbullying that have components for adolescents who have been involved with cyberbullying and their parents and to provide recommendations on effective intervention components with the goal of guiding clinical practice. A systematic review was conducted using the Institute of Medicine guidelines. A comprehensive electronic literature search was completed targeting interventions of cyberbullying in any setting. No date limits were used. Literature was searched in MEDLINE, Cumulative Index of Nursing and Allied Health Literature (CINAHL), PubMed, Communication and Mass Media Complete, Education Information Resource Center (ERIC), and PsycINFO databases. The following search terms were applied "cyberbullying" + "intervention" or "treatment" or "therapy" or "program." Only articles with a pediatric population were selected for review. Seventeen cyberbullying intervention programs in 23 articles were found to meet the search criteria. The most frequently used intervention components included education on cyberbullying for the adolescent, coping skills, empathy training, communication and social skills, and digital citizenship. Parent education on cyberbullying was also found to be important and was included in programs with significant outcomes. As youth present to healthcare providers with symptoms related to cyberbullying, effective interventions are needed to guide evidence-based practice. This review supports educating the individual youth and parent on cyberbullying and teaching the youth skills in communication and social, empathy, coping with cyberbullying, and digital citizenship. © 2017 Sigma Theta Tau International.