Improving Global Access to New Vaccines: Intellectual Property, Technology Transfer, and Regulatory Pathways

PubMed Central

2014-01-01

The 2012 World Health Assembly Global Vaccine Action Plan called for global access to new vaccines within 5 years of licensure. Current approaches have proven insufficient to achieve sustainable vaccine pricing within such a timeline. Paralleling the successful strategy of generic competition to bring down drug prices, a clear consensus is emerging that market entry of multiple suppliers is a critical factor in expeditiously bringing down prices of new vaccines. In this context, key target objectives for improving access to new vaccines include overcoming intellectual property obstacles, streamlining regulatory pathways for biosimilar vaccines, and reducing market entry timelines for developing-country vaccine manufacturers by transfer of technology and know-how. I propose an intellectual property, technology, and know-how bank as a new approach to facilitate widespread access to new vaccines in low- and middle-income countries by efficient transfer of patented vaccine technologies to multiple developing-country vaccine manufacturers. PMID:25211753

Improving global access to new vaccines: intellectual property, technology transfer, and regulatory pathways.

PubMed

Crager, Sara Eve

2014-11-01

The 2012 World Health Assembly Global Vaccine Action Plan called for global access to new vaccines within 5 years of licensure. Current approaches have proven insufficient to achieve sustainable vaccine pricing within such a timeline. Paralleling the successful strategy of generic competition to bring down drug prices, a clear consensus is emerging that market entry of multiple suppliers is a critical factor in expeditiously bringing down prices of new vaccines. In this context, key target objectives for improving access to new vaccines include overcoming intellectual property obstacles, streamlining regulatory pathways for biosimilar vaccines, and reducing market entry timelines for developing-country vaccine manufacturers by transfer of technology and know-how. I propose an intellectual property, technology, and know-how bank as a new approach to facilitate widespread access to new vaccines in low- and middle-income countries by efficient transfer of patented vaccine technologies to multiple developing-country vaccine manufacturers.

[Improving global access to new vaccines: intellectual property, technology transfer, and regulatory pathways].

PubMed

Crager, Sara Eve

2015-01-01

The 2012 World Health Assembly Global Vaccine Action Plan called for global access to new vaccines within 5 years of licensure. Current approaches have proven insufficient to achieve sustainable vaccine pricing within such a timeline. Paralleling the successful strategy of generic competition to bring down drug prices, a clear consensus is emerging that market entry of multiple suppliers is a critical factor in expeditiously bringing down prices of new vaccines. In this context, key target objectives for improving access to new vaccines include overcoming intellectual property obstacles, streamlining regulatory pathways for biosimilar vaccines, and reducing market entry timelines for developing-country vaccine manufacturers by transfer of technology and know-how. I propose an intellectual property, technology, and know-how bank as a new approach to facilitate widespread access to new vaccines in low- and middle-income countries by efficient transfer of patented vaccine technologies to multiple developing-country vaccine manufacturers.

Mouse Xenograft Model for Mesothelioma | NCI Technology Transfer Center | TTC

Cancer.gov

The National Cancer Institute is seeking parties interested in collaborative research to co-develop, evaluate, or commercialize a new mouse model for monoclonal antibodies and immunoconjugates that target malignant mesotheliomas. Applications of the technology include models for screening compounds as potential therapeutics for mesothelioma and for studying the pathology of mesothelioma.

Breast imaging technology: Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects - applications to breast cancer

PubMed Central

Berger, Frank; Sam Gambhir, Sanjiv

2001-01-01

A variety of imaging technologies is being investigated as tools for studying gene expression in living subjects. Two technologies that use radiolabeled isotopes are single photon emission computed tomography (SPECT) and positron emission tomography (PET). A relatively high sensitivity, a full quantitative tomographic capability, and the ability to extend small animal imaging assays directly into human applications characterize radionuclide approaches. Various radiolabeled probes (tracers) can be synthesized to target specific molecules present in breast cancer cells. These include antibodies or ligands to target cell surface receptors, substrates for intracellular enzymes, antisense oligodeoxynucleotide probes for targeting mRNA, probes for targeting intracellular receptors, and probes for genes transferred into the cell. We briefly discuss each of these imaging approaches and focus in detail on imaging reporter genes. In a PET reporter gene system for in vivo reporter gene imaging, the protein products of the reporter genes sequester positron emitting reporter probes. PET subsequently measures the PET reporter gene dependent sequestration of the PET reporter probe in living animals. We describe and review reporter gene approaches using the herpes simplex type 1 virus thymidine kinase and the dopamine type 2 receptor genes. Application of the reporter gene approach to animal models for breast cancer is discussed. Prospects for future applications of the transgene imaging technology in human gene therapy are also discussed. Both SPECT and PET provide unique opportunities to study animal models of breast cancer with direct application to human imaging. Continued development of new technology, probes and assays should help in the better understanding of basic breast cancer biology and in the improved management of breast cancer patients. PMID:11250742

Exploration of new perspectives and limitations in Agrobacterium-mediated gene transfer technology. Final report, June 1, 1992--May 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marton, L.

1996-02-01

Genetic manipulation of plants often involves the introduction of homologous or partly homologous genes. Ectropic introduction of homologous sequences into plant genomes may trigger epigenetic changes, making expression of the genes unpredictable. The main project objective was to examine the feasibility of using Agrobacterium-mediated gene transfer for homologous gene targeting in plants.

Creating genetically modified pigs by using nuclear transfer

PubMed Central

Lai, Liangxue; Prather, Randall S

2003-01-01

Nuclear transfer (NT) is a procedure by which genetically identical individuals can be created. The technology of pig somatic NT, including in vitro maturation of oocytes, isolation and treatment of donor cells, artificial activation of reconstructed oocytes, embryo culture and embryo transfer, has been intensively studied in recent years, resulting in birth of cloned pigs in many labs. While it provides an efficient method for producing transgenic pigs, more importantly, it is the only way to produce gene-targeted pigs. So far pig cloning has been successfully used to produce transgenic pigs expressing the green fluorescence protein, expand transgenic pig groups and create gene targeted pigs which are deficient of alpha-1,3-galactosyltransferase. The production of pigs with genetic modification by NT is now in the transition from investigation to practical use. Although the efficiency of somatic cell NT in pig, when measured as development to term as a proportion of oocytes used, is not high, it is anticipated that the ability of making specific modifications to the swine genome will result in this technology having a large impact not only on medicine but also on agriculture. PMID:14613542

Strategies for Increasing IT Enrollment: Recruiting, Retaining and Encouraging the Transfer of Women and Underrepresented Groups to Four-Year Colleges

ERIC Educational Resources Information Center

Tupper, Donna Hiestand; Leitherer, Barbara; Sorkin, Sylvia; Gore, Mary Elizabeth

2010-01-01

Through the support of the National Science Foundation,, The Community College of Baltimore County has begun two separate initiatives to increase the number of women and underrepresented minorities enrolled in technological majors. Started in 2003, the Grace Hopper Scholars Program targets specifically women interested in careers in technology,…

AAV viral vector delivery to the brain by shape-conforming MR-guided infusions.

PubMed

Bankiewicz, Krystof S; Sudhakar, Vivek; Samaranch, Lluis; San Sebastian, Waldy; Bringas, John; Forsayeth, John

2016-10-28

Gene transfer technology offers great promise as a potential therapeutic approach to the brain but has to be viewed as a very complex technology. Success of ongoing clinical gene therapy trials depends on many factors such as selection of the correct genetic and anatomical target in the brain. In addition, selection of the viral vector capable of transfer of therapeutic gene into target cells, along with long-term expression that avoids immunotoxicity has to be established. As with any drug development strategy, delivery of gene therapy has to be consistent and predictable in each study subject. Failed drug and vector delivery will lead to failed clinical trials. In this article, we describe our experience with AAV viral vector delivery system, that allows us to optimize and monitor in real time viral vector administration into affected regions of the brain. In addition to discussing MRI-guided technology for administration of AAV vectors we have developed and now employ in current clinical trials, we also describe ways in which infusion cannula design and stereotactic trajectory may be used to maximize the anatomical coverage by using fluid backflow. This innovative approach enables more precise coverage by fitting the shape of the infusion to the shape of the anatomical target. Copyright © 2016 Elsevier B.V. All rights reserved.

Research utilization in the building industry: decision model and preliminary assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watts, R.L.; Johnson, D.R.; Smith, S.A.

1985-10-01

The Research Utilization Program was conceived as a far-reaching means for managing the interactions of the private sector and the federal research sector as they deal with energy conservation in buildings. The program emphasizes a private-public partnership in planning a research agenda and in applying the results of ongoing and completed research. The results of this task support the hypothesis that the transfer of R and D results to the buildings industry can be accomplished more efficiently and quickly by a systematic approach to technology transfer. This systematic approach involves targeting decision makers, assessing research and information needs, properly formatingmore » information, and then transmitting the information through trusted channels. The purpose of this report is to introduce elements of a market-oriented knowledge base, which would be useful to the Building Systems Division, the Office of Buildings and Community Systems and their associated laboratories in managing a private-public research partnership on a rational systematic basis. This report presents conceptual models and data bases that can be used in formulating a technology transfer strategy and in planning technology transfer programs.« less

Colon Cancer Biomarkers To Identify Patients Suitable For Therapeutic Intervention | NCI Technology Transfer Center | TTC

Cancer.gov

The National Cancer Institute's Laboratory of Human Carcinogenesis is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize cancer biomarkers and therapeutic targets.

Electronic Commerce Resource Centers. An Industry--University Partnership.

ERIC Educational Resources Information Center

Gulledge, Thomas R.; Sommer, Rainer; Tarimcilar, M. Murat

1999-01-01

Electronic Commerce Resource Centers focus on transferring emerging technologies to small businesses through university/industry partnerships. Successful implementation hinges on a strategic operating plan, creation of measurable value for customers, investment in customer-targeted training, and measurement of performance outputs. (SK)

Research on moving target defense based on SDN

NASA Astrophysics Data System (ADS)

Chen, Mingyong; Wu, Weimin

2017-08-01

An address mutation strategy was proposed. This strategy provided an unpredictable change in address, replacing the real address of the packet forwarding process and path mutation, thus hiding the real address of the host and path. a mobile object defense technology based on Spatio-temporal Mutation on this basis is proposed, Using the software Defined Network centralized control architecture advantage combines sFlow traffic monitoring technology and Moving Target Defense. A mutated time period which can be changed in real time according to the network traffic is changed, and the destination address is changed while the controller abruptly changes the address while the data packet is transferred between the switches to construct a moving target, confusing the host within the network, thereby protecting the host and network.

Fully Human Antibodies and Antibody Drug Conjugates Targeting CD276 (B7-H3) for the Treatment of Cancer | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at the National Cancer Institute (NCI) seek research collaborations or licensees for a monoclonal antibody targeting CD276, also known as B7-H3, and related conjugates. The antibody and antibody drug conjugates (ADC) containing the antibody of the current invention were tested in vivo and have potential for use in cancer immunotherapy.

Somatic Mosaicism for Cancer Predisposition Genes and Pancreatic Cancer

DTIC Science & Technology

2017-07-01

cancer or had a strong family history of cancer. Thus far all tissues from 21 of these patients have undergone targeted sequencing using a 468 gene...major accomplishments, innovations , successes, or any change in practice or behavior that has come about as a result of the project relative to...What was the impact on technology transfer? What was the impact on society beyond science and technology ? Nothing to

Introduction of Virtualization Technology to Multi-Process Model Checking

NASA Technical Reports Server (NTRS)

Leungwattanakit, Watcharin; Artho, Cyrille; Hagiya, Masami; Tanabe, Yoshinori; Yamamoto, Mitsuharu

2009-01-01

Model checkers find failures in software by exploring every possible execution schedule. Java PathFinder (JPF), a Java model checker, has been extended recently to cover networked applications by caching data transferred in a communication channel. A target process is executed by JPF, whereas its peer process runs on a regular virtual machine outside. However, non-deterministic target programs may produce different output data in each schedule, causing the cache to restart the peer process to handle the different set of data. Virtualization tools could help us restore previous states of peers, eliminating peer restart. This paper proposes the application of virtualization technology to networked model checking, concentrating on JPF.

Ice-assisted transfer of carbon nanotube arrays.

PubMed

Wei, Haoming; Wei, Yang; Lin, Xiaoyang; Liu, Peng; Fan, Shoushan; Jiang, Kaili

2015-03-11

Decoupling the growth and the application of nanomaterials by transfer is an important issue in nanotechnology. Here, we developed an efficient transfer technique for carbon nanotube (CNT) arrays by using ice as a binder to temporarily bond the CNT array and the target substrate. Ice makes it an ultraclean transfer because the evaporation of ice ensures that no contaminants are introduced. The transferred superaligned carbon nanotube (SACNT) arrays not only keep their original appearance and initial alignment but also inherit their spinnability, which is the most desirable feature. The transfer-then-spin strategy can be employed to fabricate patterned CNT arrays, which can act as 3-dimensional electrodes in CNT thermoacoustic chips. Besides, the flip-chipped CNTs are promising field electron emitters. Furthermore, the ice-assisted transfer technique provides a cost-effective solution for mass production of SACNTs, giving CNT technologies a competitive edge, and this method may inspire new ways to transfer other nanomaterials.

Highly Enhanced Electromechanical Stability of Large-Area Graphene with Increased Interfacial Adhesion Energy by Electrothermal-Direct Transfer for Transparent Electrodes.

PubMed

Kim, Jangheon; Kim, Gi Gyu; Kim, Soohyun; Jung, Wonsuk

2016-09-07

Graphene, a two-dimensional sheet of carbon atoms in a hexagonal lattice structure, has been extensively investigated for research and industrial applications as a promising material with outstanding electrical, mechanical, and chemical properties. To fabricate graphene-based devices, graphene transfer to the target substrate with a clean and minimally defective surface is the first step. However, graphene transfer technologies require improvement in terms of uniform transfer with a clean, nonfolded and nontorn area, amount of defects, and electromechanical reliability of the transferred graphene. More specifically, uniform transfer of a large area is a key challenge when graphene is repetitively transferred onto pretransferred layers because the adhesion energy between graphene layers is too low to ensure uniform transfer, although uniform multilayers of graphene have exhibited enhanced electrical and optical properties. In this work, we developed a newly suggested electrothermal-direct (ETD) transfer method for large-area high quality monolayer graphene with less defects and an absence of folding or tearing of the area at the surface. This method delivers uniform multilayer transfer of graphene by repetitive monolayer transfer steps based on high adhesion energy between graphene layers and the target substrate. To investigate the highly enhanced electromechanical stability, we conducted mechanical elastic bending experiments and reliability tests in a highly humid environment. This ETD-transferred graphene is expected to replace commercial transparent electrodes with ETD graphene-based transparent electrodes and devices such as a touch panels with outstanding electromechanical stability.

The Commtech Methodology: A Demand-Driven Approach to Efficient, Productive, and Measurable Technology Transfer and Commercialization

NASA Technical Reports Server (NTRS)

Horsham, Gary A. P.

1999-01-01

This paper presents a comprehensive review and assessment of a demonstration technology transfer and commercialization prouram called "CommTech". The pro-ram was conceived and initiated in early to mid-fiscal year 1995, and extended roughly three years into the future. Market research sources were used to initially gather primary technological problems and needs data from non-aerospace companies in three targeted industry sectors: environmental, surface transportation, and bioengineering. Company-supplied information served as input data to activate or start-up an internal, phased matchmaking process. This process was based on technical-level relationship exploration followed by business-level agreement negotiations. and culminated with project management and execution. Space Act Agreements represented near-term outputs. Company product or process commercialization derived from NASA Glenn support and measurable economic effects represented far-term outputs.

Virus-Like Particles That Can Deliver Proteins and RNA | NCI Technology Transfer Center | TTC

Cancer.gov

The present invention describes novel virus-like particles (VLPs) that are capable of binding to and replicating within a target mammalian cell, including human cells. The claimed VLPs are safer than viral delivery because they are incapable of re-infecting target cells. The National Cancer Institute's Protein Expression Laboratory seeks parties interested in licensing the novel delivery of RNA to mammalian cells using virus-like particles.

Human Monoclonal Antibodies Targeting Glypican-2 in Neuroblastoma | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at the National Cancer Institute’s Laboratory of Molecular Biology (NCI LMB) have developed and isolated several single domain monoclonal human antibodies against GPC2. NCI seeks parties interested in licensing or co-developing GPC2 antibodies and/or conjugates.

A range/depth modulation transfer function (RMTF) framework for characterizing 3D imaging LADAR performance

NASA Astrophysics Data System (ADS)

Staple, Bevan; Earhart, R. P.; Slaymaker, Philip A.; Drouillard, Thomas F., II; Mahony, Thomas

2005-05-01

3D imaging LADARs have emerged as the key technology for producing high-resolution imagery of targets in 3-dimensions (X and Y spatial, and Z in the range/depth dimension). Ball Aerospace & Technologies Corp. continues to make significant investments in this technology to enable critical NASA, Department of Defense, and national security missions. As a consequence of rapid technology developments, two issues have emerged that need resolution. First, the terminology used to rate LADAR performance (e.g., range resolution) is inconsistently defined, is improperly used, and thus has become misleading. Second, the terminology does not include a metric of the system"s ability to resolve the 3D depth features of targets. These two issues create confusion when translating customer requirements into hardware. This paper presents a candidate framework for addressing these issues. To address the consistency issue, the framework utilizes only those terminologies proposed and tested by leading LADAR research and standards institutions. We also provide suggestions for strengthening these definitions by linking them to the well-known Rayleigh criterion extended into the range dimension. To address the inadequate 3D image quality metrics, the framework introduces the concept of a Range/Depth Modulation Transfer Function (RMTF). The RMTF measures the impact of the spatial frequencies of a 3D target on its measured modulation in range/depth. It is determined using a new, Range-Based, Slanted Knife-Edge test. We present simulated results for two LADAR pulse detection techniques and compare them to a baseline centroid technique. Consistency in terminology plus a 3D image quality metric enable improved system standardization.

A Gene-Based Prognostic for Hepatocellular Carcinoma Patient Response to Adjuvant Transcatheter Arterial Chemoembolization | NCI Technology Transfer Center | TTC

Cancer.gov

The gold standard of care for hepatocellular carcinoma patients with intermediate- to locally advanced tumors is transcatheter arterial chemoembolization (TACE), a procedure whereby the tumor is targeted both with local chemotherapy and restriction of local blood supply. NCI scientists have identified a 14-gene signature predictive of response to TACE, and NCI seeks licensees or co-development partners to develop the technology toward commercialization.

Viral and Synthetic RNA Vector Technologies and Applications

PubMed Central

Schott, Juliane W; Morgan, Michael; Galla, Melanie; Schambach, Axel

2016-01-01

Use of RNA is an increasingly popular method to transiently deliver genetic information for cell manipulation in basic research and clinical therapy. In these settings, viral and nonviral RNA platforms are employed for delivery of small interfering RNA and protein-coding mRNA. Technological advances allowing RNA modification for increased stability, improved translation and reduced immunogenicity have led to increased use of nonviral synthetic RNA, which is delivered in naked form or upon formulation. Alternatively, highly efficient viral entry pathways are exploited to transfer genes of interest as RNA incorporated into viral particles. Current viral RNA transfer technologies are derived from Retroviruses, nonsegmented negative-strand RNA viruses or positive-stranded Alpha- and Flaviviruses. In retroviral particles, the genes of interest can either be incorporated directly into the viral RNA genome or as nonviral RNA. Nonsegmented negative-strand virus-, Alpha- and Flavivirus-derived vectors support prolonged expression windows through replication of viral RNA encoding genes of interest. Mixed technologies combining viral and nonviral components are also available. RNA transfer is ideal for all settings that do not require permanent transgene expression and excludes potentially detrimental DNA integration into the target cell genome. Thus, RNA-based technologies are successfully applied for reprogramming, transdifferentiation, gene editing, vaccination, tumor therapy, and gene therapy. PMID:27377044

Nanofabrication on unconventional substrates using transferred hard masks

DOE PAGES

Li, Luozhou; Bayn, Igal; Lu, Ming; ...

2015-01-15

Here, a major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silicon membrane hard masks, patterned using standard lithography and mature silicon processing technology. These masks, transferred precisely onto targeted regions, can be in the millimetre scale. They allow for fabrication on a wide range of substrates, including rough, soft, and non-conductive materials, enabling feature linewidths down to 10 nm. Plasma etching, lift-off, and ion implantationmore » are realized without the need for scanning electron/ion beam processing, UV exposure, or wet etching on target substrates.« less

Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at the National Cancer Institute (NCI) RNA Biology Laboratory have developed nanoparticles that can deliver an agent (i.e., therapeutic or imaging) and release the agent upon targeted photoactivation allowing for controlled temporal and localized release of the agent.

Novel Therapeutic for Inflammatory Disorders | NCI Technology Transfer Center | TTC

Cancer.gov

The National Cancer Institute's Frederick National Lab's Molecular Targets Laboratory is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a novel inhibitor of the NF-kappa B signal transduction pathway, which leads to many inflammatory disorders.

Analysis of the efficiency of recombinant Escherichia coli strain cultivation in a gas-vortex bioreactor.

PubMed

Savelyeva, Anna V; Nemudraya, Anna A; Podgornyi, Vladimir F; Laburkina, Nadezhda V; Ramazanov, Yuriy A; Repkov, Andrey P; Kuligina, Elena V; Richter, Vladimir A

2017-09-01

The levels of aeration and mass transfer are critical parameters required for an efficient aerobic bioprocess, and directly depend on the design features of exploited bioreactors. A novel apparatus, using gas vortex for aeration and mass transfer processes, was constructed in the Center of Vortex Technologies (Novosibirsk, Russia). In this paper, we compared the efficiency of recombinant Escherichia coli strain cultivation using novel gas-vortex technology with conventional bioprocess technologies such as shake flasks and bioreactors with mechanical stirrers. We demonstrated that the system of aeration and agitation used in gas-vortex bioreactors provides 3.6 times higher volumetric oxygen transfer coefficient in comparison with mechanical bioreactor. The use of gas-vortex bioreactor for recombinant E. coli strain cultivation allows to increase the efficiency of target protein expression at 2.2 times for BL21(DE3)/pFK2 strain and at 3.5 times for auxotrophic C600/pRT strain (in comparison with stirred bioreactor). © 2016 International Union of Biochemistry and Molecular Biology, Inc.

Additive and Photochemical Manufacturing of Copper

PubMed Central

Yung, Winco K. C.; Sun, Bo; Meng, Zhengong; Huang, Junfeng; Jin, Yingdi; Choy, Hang Shan; Cai, Zhixiang; Li, Guijun; Ho, Cheuk Lam; Yang, Jinlong; Wong, Wai Yeung

2016-01-01

In recent years, 3D printing technologies have been extensively developed, enabling rapid prototyping from a conceptual design to an actual product. However, additive manufacturing of metals in the existing technologies is still cost-intensive and time-consuming. Herein a novel platform for low-cost additive manufacturing is introduced by simultaneously combining the laser-induced forward transfer (LIFT) method with photochemical reaction. Using acrylonitrile butadiene styrene (ABS) polymer as the sacrificial layer, sufficient ejection momentum can be generated in the LIFT method. A low-cost continuous wave (CW) laser diode at 405 nm was utilized and proved to be able to transfer the photochemically synthesized copper onto the target substrate. The wavelength-dependent photochemical behaviour in the LIFT method was verified and characterized by both theoretical and experimental studies compared to 1064 nm fiber laser. The conductivity of the synthesized copper patterns could be enhanced using post electroless plating while retaining the designed pattern shapes. Prototypes of electronic circuits were accordingly built and demonstrated for powering up LEDs. Apart from pristine PDMS materials with low surface energies, the proposed method can simultaneously perform laser-induced forward transfer and photochemical synthesis of metals, starting from their metal oxide forms, onto various target substrates such as polyimide, glass and thermoplastics. PMID:28000733

Additive and Photochemical Manufacturing of Copper

NASA Astrophysics Data System (ADS)

Yung, Winco K. C.; Sun, Bo; Meng, Zhengong; Huang, Junfeng; Jin, Yingdi; Choy, Hang Shan; Cai, Zhixiang; Li, Guijun; Ho, Cheuk Lam; Yang, Jinlong; Wong, Wai Yeung

2016-12-01

In recent years, 3D printing technologies have been extensively developed, enabling rapid prototyping from a conceptual design to an actual product. However, additive manufacturing of metals in the existing technologies is still cost-intensive and time-consuming. Herein a novel platform for low-cost additive manufacturing is introduced by simultaneously combining the laser-induced forward transfer (LIFT) method with photochemical reaction. Using acrylonitrile butadiene styrene (ABS) polymer as the sacrificial layer, sufficient ejection momentum can be generated in the LIFT method. A low-cost continuous wave (CW) laser diode at 405 nm was utilized and proved to be able to transfer the photochemically synthesized copper onto the target substrate. The wavelength-dependent photochemical behaviour in the LIFT method was verified and characterized by both theoretical and experimental studies compared to 1064 nm fiber laser. The conductivity of the synthesized copper patterns could be enhanced using post electroless plating while retaining the designed pattern shapes. Prototypes of electronic circuits were accordingly built and demonstrated for powering up LEDs. Apart from pristine PDMS materials with low surface energies, the proposed method can simultaneously perform laser-induced forward transfer and photochemical synthesis of metals, starting from their metal oxide forms, onto various target substrates such as polyimide, glass and thermoplastics.

Development of a Technology Transfer Score for Evaluating Research Proposals: Case Study of Demand Response Technologies in the Pacific Northwest

NASA Astrophysics Data System (ADS)

Estep, Judith

Investment in Research and Development (R&D) is necessary for innovation, allowing an organization to maintain a competitive edge. The U.S. Federal Government invests billions of dollars, primarily in basic research technologies to help fill the pipeline for other organizations to take the technology into commercialization. However, it is not about just investing in innovation, it is about converting that research into application. A cursory review of the research proposal evaluation criteria suggests that there is little to no emphasis placed on the transfer of research results. This effort is motivated by a need to move research into application. One segment that is facing technology challenges is the energy sector. Historically, the electric grid has been stable and predictable; therefore, there were no immediate drivers to innovate. However, an aging infrastructure, integration of renewable energy, and aggressive energy efficiency targets are motivating the need for research and to put promising results into application. Many technologies exist or are in development but the rate at which they are being adopted is slow. The goal of this research is to develop a decision model that can be used to identify the technology transfer potential of a research proposal. An organization can use the model to select the proposals whose research outcomes are more likely to move into application. The model begins to close the chasm between research and application--otherwise known as the "valley of death". A comprehensive literature review was conducted to understand when the idea of technology application or transfer should begin. Next, the attributes that are necessary for successful technology transfer were identified. The emphasis of successful technology transfer occurs when there is a productive relationship between the researchers and the technology recipient. A hierarchical decision model, along with desirability curves, was used to understand the complexities of the researcher and recipient relationship, specific to technology transfer. In this research, the evaluation criteria of several research organizations were assessed to understand the extent to which the success attributes that were identified in literature were considered when reviewing research proposals. While some of the organizations included a few of the success attributes, none of the organizations considered all of the attributes. In addition, none of the organizations quantified the value of the success attributes. The effectiveness of the model relies extensively on expert judgments to complete the model validation and quantification. Subject matter experts ranging from senior executives with extensive experience in technology transfer to principal research investigators from national labs, universities, utilities, and non-profit research organizations were used to ensure a comprehensive and cross-functional validation and quantification of the decision model. The quantified model was validated using a case study involving demand response (DR) technology proposals in the Pacific Northwest. The DR technologies were selected based on their potential to solve some of the region's most prevalent issues. In addition, several sensitivity scenarios were developed to test the model's response to extreme case scenarios, impact of perturbations in expert responses, and if it can be applied to other than demand response technologies. In other words, is the model technology agnostic? In addition, the flexibility of the model to be used as a tool for communicating which success attributes in a research proposal are deficient and need strengthening and how improvements would increase the overall technology transfer score were assessed. The low scoring success attributes in the case study proposals (e.g. project meetings, etc.) were clearly identified as the areas to be improved for increasing the technology transfer score. As a communication tool, the model could help a research organization identify areas they could bolster to improve their overall technology transfer score. Similarly, the technology recipient could use the results to identify areas that need to be reinforced, as the research is ongoing. The research objective is to develop a decision model resulting in a technology transfer score that can be used to assess the technology transfer potential of a research proposal. The technology transfer score can be used by an organization in the development of a research portfolio. An organization's growth, in a highly competitive global market, hinges on superior R&D performance and the ability to apply the results. The energy sector is no different. While there is sufficient research being done to address the issues facing the utility industry, the rate at which technologies are adopted is lagging. The technology transfer score has the potential to increase the success of crossing the chasm to successful application by helping an organization make informed and deliberate decisions about their research portfolio.

Thermodynamic analysis and subscale modeling of space-based orbit transfer vehicle cryogenic propellant resupply

NASA Technical Reports Server (NTRS)

Defelice, David M.; Aydelott, John C.

1987-01-01

The resupply of the cryogenic propellants is an enabling technology for spacebased orbit transfer vehicles. As part of the NASA Lewis ongoing efforts in microgravity fluid management, thermodynamic analysis and subscale modeling techniques were developed to support an on-orbit test bed for cryogenic fluid management technologies. Analytical results have shown that subscale experimental modeling of liquid resupply can be used to validate analytical models when the appropriate target temperature is selected to relate the model to its prototype system. Further analyses were used to develop a thermodynamic model of the tank chilldown process which is required prior to the no-vent fill operation. These efforts were incorporated into two FORTRAN programs which were used to present preliminary analyticl results.

Airborne Remote Sensing (ARS) for Agricultural Research and Commercialization Applications

NASA Technical Reports Server (NTRS)

Narayanan, Ram; Bowen, Brent D.; Nickerson, Jocelyn S.

2002-01-01

Tremendous advances in remote sensing technology and computing power over the last few decades are now providing scientists with the opportunity to investigate, measure, and model environmental patterns and processes with increasing confidence. Such advances are being pursued by the Nebraska Remote Sensing Facility, which consists of approximately 30 faculty members and is very competitive with other institutions in the depth of the work that is accomplished. The development of this facility targeted at applications, commercialization, and education programs in the area of precision agriculture provides a unique opportunity. This critical area is within the scope of NASA goals and objectives of NASA s Applications, Technology Transfer, Commercialization, and Education Division and the Earth Science Enterprise. This innovative integration of Aerospace (Aeronautics) Technology Enterprise applications with other NASA enterprises serves as a model of cross-enterprise transfer of science with specific commercial applications.

Proceedings of the international workshop on the technology and thermal hydraulics of heavy liquid metals (Hg, Pb, Bi, and their eutectics)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Appleton, B.R.; Bauer, G.S.

1996-06-01

The International Workshop on the Technology and Thermal Hydraulics of Heavy Liquid Metals (Schruns Workshop) was organized to assess the R&D and technology problems associated with designing and building a heavy liquid metal target for a spallation neutron source. The European scientific community is completing a feasibility study for a future, accelerator-based, pulsed spallation neutron source that would deliver a beam power of 5 megawatts (MW) to a target. They have concluded that a liquid metal target is preferable to conventional solid targets for handling the extreme radiation environments, high heat loads, and pulsed power. Similarly, the ORNL has beenmore » funded by the DOE to design a high-power, pulsed spallation neutron source that would begin operation at about 1 MW but that could be upgraded to significantly higher powers in the future. Again, the most feasible target design appears to be a liquid metal target. Since the expertise needed to consider these problems resides in a number of disparate disciplines not normally covered by existing conferences, this workshop was organized to bring a small number of scientists and engineers together to assess the opportunities for building such a target. The objectives and goals of the Schruns Workshop were to: review and share existing information on the science and technology of heavy liquid metal systems. Evaluate the opportunities and limitations of materials compatibility, thermal hydraulics and heat transfer, chemical reactions, corrosion, radiation effects, liquid-gas mixtures, systems designs, and circuit components for a heavy liquid metal target. Establish the critical R & D and technology that is necessary to construct a liquid metal target. Explore opportunities for cooperative R & D among members of the international community that could expedite results, and share expertise and resources. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.« less

Determining Li+-Coupled Redox Targeting Reaction Kinetics of Battery Materials with Scanning Electrochemical Microscopy.

PubMed

Yan, Ruiting; Ghilane, Jalal; Phuah, Kia Chai; Pham Truong, Thuan Nguyen; Adams, Stefan; Randriamahazaka, Hyacinthe; Wang, Qing

2018-02-01

The redox targeting reaction of Li + -storage materials with redox mediators is the key process in redox flow lithium batteries, a promising technology for next-generation large-scale energy storage. The kinetics of the Li + -coupled heterogeneous charge transfer between the energy storage material and redox mediator dictates the performance of the device, while as a new type of charge transfer process it has been rarely studied. Here, scanning electrochemical microscopy (SECM) was employed for the first time to determine the interfacial charge transfer kinetics of LiFePO 4 /FePO 4 upon delithiation and lithiation by a pair of redox shuttle molecules FcBr 2 + and Fc. The effective rate constant k eff was determined to be around 3.70-6.57 × 10 -3 cm/s for the two-way pseudo-first-order reactions, which feature a linear dependence on the composition of LiFePO 4 , validating the kinetic process of interfacial charge transfer rather than bulk solid diffusion. In addition, in conjunction with chronoamperometry measurement, the SECM study disproves the conventional "shrinking-core" model for the delithiation of LiFePO 4 and presents an intriguing way of probing the phase boundary propagations induced by interfacial redox reactions. This study demonstrates a reliable method for the kinetics of redox targeting reactions, and the results provide useful guidance for the optimization of redox targeting systems for large-scale energy storage.

Monoclonal Antibody Fragments for Targeting Therapeutics to Growth Plate Cartilage | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at The Eunice Kennedy Shriver National Institute on Child Health and Human Development (NICHD) have discovered monoclonal antibodies that bind to matrilin-3, a protein specifically expressed in cartilage tissue, that could be used for treating or inhibiting growth plate disorders, such as a skeletal dysplasia or short stature. The monoclonal antibodies can also be used to target therapeutic agents, such as anti-arthritis agents, to cartilage tissue. NICHD seeks statements of capability or interest from parties interested in collaborative research to co-develop, evaluate, or commercialize treatment of skeletal disorders using targeting antibodies.

Target for Anti-Tumor Immune Responses | NCI Technology Transfer Center | TTC

Cancer.gov

The Surgery Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to carry out genotypic as well as phenotypic analysis of the 888 mel cell line in order to better understand the nature of tumor cells that respond to therapy.

A Rabbit Anti-pT1989 ATR Monoclonal Antibody for Use in Immunoassays | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at the National Cancer Institute (NCI) have developed a monoclonal antibody against ataxia telangiectasia-mutated and Rad3-related (ATR) kinase phosphorylated at threonine 1989. The antibody can be used for pharmacodynamic assays to quantify drug action on the ATR target.

Technology Transfer Issues and a New Technology Transfer Model

ERIC Educational Resources Information Center

Choi, Hee Jun

2009-01-01

The following are major issues that should be considered for efficient and effective technology transfer: conceptions of technology, technological activity and transfer, communication channels, factors affecting transfer, and models of transfer. In particular, a well-developed model of technology transfer could be used as a framework for…

Plasmonic nanobubbles for target cell-specific gene and drug delivery and multifunctional processing of heterogeneous cell systems

NASA Astrophysics Data System (ADS)

Lukianova-Hleb, Ekaterina Y.; Huye, Leslie E.; Brenner, Malcolm K.; Lapotko, Dmitri O.

2014-03-01

Cell and gene cancer therapies require ex vivo cell processing of human grafts. Such processing requires at least three steps - cell enrichment, cell separation (destruction), and gene transfer - each of which requires the use of a separate technology. While these technologies may be satisfactory for research use, they are of limited usefulness in the clinical treatment setting because they have a low processing rate, as well as a low transfection and separation efficacy and specificity in heterogeneous human grafts. Most problematic, because current technologies are administered in multiple steps - rather than in a single, multifunctional, and simultaneous procedure - they lengthen treatment process and introduce an unnecessary level of complexity, labor, and resources into clinical treatment; all these limitations result in high losses of valuable cells. We report a universal, high-throughput, and multifunctional technology that simultaneously (1) inject free external cargo in target cells, (2) destroys unwanted cells, and (3) preserve valuable non-target cells in heterogeneous grafts. Each of these functions has single target cell specificity in heterogeneous cell system, processing rate > 45 mln cell/min, injection efficacy 90% under 96% viability of the injected cells, target cell destruction efficacy > 99%, viability of not-target cells >99% The developed technology employs novel cellular agents, called plasmonic nanobubbles (PNBs). PNBs are not particles, but transient, intracellular events, a vapor nanobubbles that expand and collapse in mere nanoseconds under optical excitation of gold nanoparticles with short picosecond laser pulses. PNBs of different, cell-specific, size (1) inject free external cargo with small PNBs, (2) Destroy other target cells mechanically with large PNBs and (3) Preserve non-target cells. The multi-functionality, precision, and high throughput of all-in-one PNB technology will tremendously impact cell and gene therapies and other clinical applications that depend on ex vivo processing of heterogeneous cell systems.

Membrane bioreactors for the removal of anionic micropollutants from drinking water.

PubMed

Crespo, João G; Velizarov, Svetlozar; Reis, Maria A

2004-10-01

Biological treatment processes allow for the effective elimination of anionic micropollutants from drinking water. However, special technologies have to be implemented to eliminate the target pollutants without changing water quality, either by adding new pollutants or removing essential water components. Some innovative technologies that combine the use of membranes with the biological degradation of ionic micropollutants in order to minimize the secondary contamination of treated water include pressure-driven membrane bioreactors, gas-transfer membrane bioreactors and ion exchange membrane bioreactors.

Tape transfer atomization patterning of liquid alloys for microfluidic stretchable wireless power transfer.

PubMed

Jeong, Seung Hee; Hjort, Klas; Wu, Zhigang

2015-02-12

Stretchable electronics offers unsurpassed mechanical compliance on complex or soft surfaces like the human skin and organs. To fully exploit this great advantage, an autonomous system with a self-powered energy source has been sought for. Here, we present a new technology to pattern liquid alloys on soft substrates, targeting at fabrication of a hybrid-integrated power source in microfluidic stretchable electronics. By atomized spraying of a liquid alloy onto a soft surface with a tape transferred adhesive mask, a universal fabrication process is provided for high quality patterns of liquid conductors in a meter scale. With the developed multilayer fabrication technique, a microfluidic stretchable wireless power transfer device with an integrated LED was demonstrated, which could survive cycling between 0% and 25% strain over 1,000 times.

Tape Transfer Atomization Patterning of Liquid Alloys for Microfluidic Stretchable Wireless Power Transfer

PubMed Central

Jeong, Seung Hee; Hjort, Klas; Wu, Zhigang

2015-01-01

Stretchable electronics offers unsurpassed mechanical compliance on complex or soft surfaces like the human skin and organs. To fully exploit this great advantage, an autonomous system with a self-powered energy source has been sought for. Here, we present a new technology to pattern liquid alloys on soft substrates, targeting at fabrication of a hybrid-integrated power source in microfluidic stretchable electronics. By atomized spraying of a liquid alloy onto a soft surface with a tape transferred adhesive mask, a universal fabrication process is provided for high quality patterns of liquid conductors in a meter scale. With the developed multilayer fabrication technique, a microfluidic stretchable wireless power transfer device with an integrated LED was demonstrated, which could survive cycling between 0% and 25% strain over 1,000 times. PMID:25673261

Using bibliographic databases in technology transfer

NASA Technical Reports Server (NTRS)

Huffman, G. David

1987-01-01

When technology developed for a specific purpose is used in another application, the process is called technology transfer--the application of an existing technology to a new use or user for purposes other than those for which the technology was originally intended. Using Bibliographical Databases in Technology Transfer deals with demand-pull transfer, technology transfer that arises from need recognition, and is a guide for conducting demand-pull technology transfer studies. It can be used by a researcher as a self-teaching manual or by an instructor as a classroom text. A major problem of technology transfer is finding applicable technology to transfer. Described in detail is the solution to this problem, the use of computerized, bibliographic databases, which currently contain virtually all documented technology of the past 15 years. A general framework for locating technology is described. NASA technology organizations and private technology transfer firms are listed for consultation.

Robotic technology evolution and transfer

NASA Technical Reports Server (NTRS)

Marzwell, Neville I.

1992-01-01

A report concerning technology transfer in the area of robotics is presented in vugraph form. The following topics are discussed: definition of technology innovation and tech-transfer; concepts relevant for understanding tech-transfer; models advanced to portray tech-transfer process; factors identified as promoting tech-transfer; factors identified as impeding tech-transfer; what important roles do individuals fulfill in tech-transfer; federal infrastructure for promoting tech-transfer; federal infrastructure for promoting tech-transfer; robotic technology evolution; robotic technology transferred; and recommendations for successful robotics tech-transfer.

Current status and applications of somatic cell nuclear transfer in dogs.

PubMed

Jang, Goo; Kim, Min Kyu; Lee, Byeong Chun

2010-11-01

Although somatic cell nuclear transfer (SCNT) technology and applications are well developed in most domesticated and laboratory animals, their use in dogs has advanced only slowly. Many technical difficulties had to be overcome before preliminary experiments could be conducted. First, due to the very low efficiency of dog oocyte maturation in vitro, in vivo matured oocytes were generally used. The nucleus of an in vivo matured oocyte was removed and a donor cell (from fetal or adult fibroblasts) was injected into the oocyte. Secondly, fusion of the reconstructed oocytes was problematic, and it was found that a higher electrical voltage was necessary, in comparison to other mammalian species. By transferring the resulting fused oocytes into surrogate females, several cloned offspring were born. SCNT was also used for producing cloned wolves, validating reproductive technologies for aiding conservation of endangered or extinct breeds. Although examples of transgenesis in canine species are very sparse, SCNT studies are increasing, and together with the new field of gene targeting technology, they have been applied in many fields of veterinary or bio-medical science. This review summarizes the current status of SCNT in dogs and evaluates its potential future applications. Copyright © 2010 Elsevier Inc. All rights reserved.

Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites.

PubMed

Wang, Yanan; Song, Jiangning; Marquez-Lago, Tatiana T; Leier, André; Li, Chen; Lithgow, Trevor; Webb, Geoffrey I; Shen, Hong-Bin

2017-07-18

Matrix Metalloproteases (MMPs) are an important family of proteases that play crucial roles in key cellular and disease processes. Therefore, MMPs constitute important targets for drug design, development and delivery. Advanced proteomic technologies have identified type-specific target substrates; however, the complete repertoire of MMP substrates remains uncharacterized. Indeed, computational prediction of substrate-cleavage sites associated with MMPs is a challenging problem. This holds especially true when considering MMPs with few experimentally verified cleavage sites, such as for MMP-2, -3, -7, and -8. To fill this gap, we propose a new knowledge-transfer computational framework which effectively utilizes the hidden shared knowledge from some MMP types to enhance predictions of other, distinct target substrate-cleavage sites. Our computational framework uses support vector machines combined with transfer machine learning and feature selection. To demonstrate the value of the model, we extracted a variety of substrate sequence-derived features and compared the performance of our method using both 5-fold cross-validation and independent tests. The results show that our transfer-learning-based method provides a robust performance, which is at least comparable to traditional feature-selection methods for prediction of MMP-2, -3, -7, -8, -9 and -12 substrate-cleavage sites on independent tests. The results also demonstrate that our proposed computational framework provides a useful alternative for the characterization of sequence-level determinants of MMP-substrate specificity.

Gene and Cell Doping: The New Frontier - Beyond Myth or Reality.

PubMed

Neuberger, Elmo W I; Simon, Perikles

2017-01-01

The advent of gene transfer technologies in clinical studies aroused concerns that these technologies will be misused for performance-enhancing purposes in sports. However, during the last 2 decades, the field of gene therapy has taken a long and winding road with just a few gene therapeutic drugs demonstrating clinical benefits in humans. The current state of gene therapy is that viral vector-mediated gene transfer shows the now long-awaited initial success for safe, and in some cases efficient, gene transfer in clinical trials. Additionally, the use of small interfering RNA promises an efficient therapy through gene silencing, even though a number of safety concerns remain. More recently, the development of the molecular biological CRISPR/Cas9 system opened new possibilities for efficient and highly targeted genome editing. This chapter aims to define and consequently demystify the term "gene doping" and discuss the current reality concerning gene- and cell-based physical enhancement strategies. The technological progress in the field of gene therapy will be illustrated, and the recent clinical progress as well as technological difficulties will be highlighted. Comparing the attractiveness of these technologies with conventional doping practices reveals that current gene therapy technologies remain unattractive for doping purposes and unlikely to outperform conventional doping. However, future technological advances may raise the attractiveness of gene doping, thus making it easier to develop detection strategies. Currently available detection strategies are introduced in this chapter showing that many forms of genetic manipulation can already be detected in principle. © 2017 S. Karger AG, Basel.

Agonistic Human Monoclonal Antibodies against Death Receptor 4 (DR4) | NCI Technology Transfer Center | TTC

Cancer.gov

The National Cancer Institute is seeking parties interested in licensing human monoclonal antibodies (mAbs) that bind to death receptor 4 ("DR4"). The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its functional receptors, DR4 and DR5, have been recognized as promising targets for cancer treatment.

BioShuttle-mediated Plasmid Transfer

PubMed Central

Braun, Klaus; von Brasch, Leonie; Pipkorn, Ruediger; Ehemann, Volker; Jenne, Juergen; Spring, Herbert; Debus, Juergen; Didinger, Bernd; Rittgen, Werner; Waldeck, Waldemar

2007-01-01

An efficient gene transfer into target tissues and cells is needed for safe and effective treatment of genetic diseases like cancer. In this paper, we describe the development of a transport system and show its ability for transporting plasmids. This non-viral peptide-based BioShuttle-mediated transfer system consists of a nuclear localization address sequence realizing the delivery of the plasmid phNIS-IRES-EGFP coding for two independent reporter genes into nuclei of HeLa cells. The quantification of the transfer efficiency was achieved by measurements of the sodium iodide symporter activity. EGFP gene expression was measured with Confocal Laser Scanning Microscopy and quantified with biostatistical methods by analysis of the frequency of the amplitude distribution in the CLSM images. The results demonstrate that the “BioShuttle”-Technology is an appropriate tool for an effective transfer of genetic material carried by a plasmid. PMID:18026568

Technology transfer within the NASA Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Plotkin, Henry H.

1992-01-01

Viewgraphs on technology transfer within the NASA Goddard Space Flight Center presented to Civil Space Technology Development workshop on technology transfer and effectiveness are provided. Topics covered include: obstacles to technology transfer; technology transfer improvement program at GSFC: communication between technology developers and users; and user feedback to technologists.

Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer.

PubMed

Nande, Rounak; Greco, Adelaide; Gossman, Michael S; Lopez, Jeffrey P; Claudio, Luigi; Salvatore, Marco; Brunetti, Arturo; Denvir, James; Howard, Candace M; Claudio, Pier Paolo

2013-06-01

Combining radiation therapy and direct intratumoral (IT) injection of adenoviral vectors has been explored as a means to enhance the therapeutic potential of gene transfer. A major challenge for gene transfer is systemic delivery of nucleic acids directly into an affected tissue. Ultrasound (US) contrast agents (microbubbles) are viable candidates to enhance targeted delivery of systemically administered genes. Here we show that p53, pRB, and p130 gene transfer mediated by US cavitation of microbubbles at the tumor site resulted in targeted gene transduction and increased reduction in tumor growth compared to DU-145 prostate cancer cell xenografts treated intratumorally with adenovirus (Ad) or radiation alone. Microbubble-assisted/US-mediated Ad.p53 and Ad.RB treated tumors showed significant reduction in tumor volume compared to Ad.p130 treated tumors (p<0.05). Additionally, US mediated microbubble delivery of p53 and RB combined with external beam radiation resulted in the most profound tumor reduction in DU-145 xenografted nude mice (p<0.05) compared to radiation alone. These findings highlight the potential therapeutic applications of this novel image-guided gene transfer technology in combination with external beam radiation for prostate cancer patients with therapy resistant disease.

Tattoo-Paper Transfer as a Versatile Platform for All-Printed Organic Edible Electronics.

PubMed

Bonacchini, Giorgio E; Bossio, Caterina; Greco, Francesco; Mattoli, Virgilio; Kim, Yun-Hi; Lanzani, Guglielmo; Caironi, Mario

2018-04-01

The use of natural or bioinspired materials to develop edible electronic devices is a potentially disruptive technology that can boost point-of-care testing. The technology exploits devices that can be safely ingested, along with pills or even food, and operated from within the gastrointestinal tract. Ingestible electronics can potentially target a significant number of biomedical applications, both as therapeutic and diagnostic tool, and this technology may also impact the food industry, by providing ingestible or food-compatible electronic tags that can "smart" track goods and monitor their quality along the distribution chain. Temporary tattoo-paper is hereby proposed as a simple and versatile platform for the integration of electronics onto food and pharmaceutical capsules. In particular, the fabrication of all-printed organic field-effect transistors on untreated commercial tattoo-paper, and their subsequent transfer and operation on edible substrates with a complex nonplanar geometry is demonstrated. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Targeting the S1P Axis and Development of a Novel Therapy for Obesity Related Triple Negative Breast Cancer

DTIC Science & Technology

2017-09-01

neuropathic pain associated with chemotherapy. Moreover, our recent 7 work shows that targeting the S1P/S1PR1 axis by treatment with FTY720 greatly...reduces cancer-induced bone pain and neuroinflammation (Grenald et al., 2017) and supports potential fast-track clinical application of the FDA...approved drug, FTY720, as a therapeutic avenue for cancer-induced bone pain . 4.3. The Impact on Technology Transfer Nothing to report 4.4. The impact on

Solar Electric Propulsion Vehicle Design Study for Cargo Transfer to Earth-moon L1

NASA Technical Reports Server (NTRS)

Sarver-Verhey, Timothy R.; Kerslake, Thomas W.; Rawlin, Vincent K.; Falck, Robert D.; Dudzinski, Leonard J.; Oleson, Steven R.

2002-01-01

A design study for a cargo transfer vehicle using solar electric propulsion was performed for NASA's Revolutionary Aerospace Systems Concepts program. Targeted for 2016, the solar electric propulsion (SEP) transfer vehicle is required to deliver a propellant supply module with a mass of approximately 36 metric tons from Low Earth Orbit to the first Earth-Moon libration point (LL1) within 270 days. Following an examination of propulsion and power technology options, a SEP transfer vehicle design was selected that incorporated large-area (approx. 2700 sq m) thin film solar arrays and a clustered engine configuration of eight 50 kW gridded ion thrusters mounted on an articulated boom. Refinement of the SEP vehicle design was performed iteratively to properly estimate the required xenon propellant load for the out-bound orbit transfer. The SEP vehicle performance, including the xenon propellant estimation, was verified via the SNAP trajectory code. Further efforts are underway to extend this system model to other orbit transfer missions.

The 'CommTech' Methodology: A Demand-Driven Approach to Efficient, Productive and Measurable Technology Transfer

NASA Technical Reports Server (NTRS)

Horsham, Gray A. P.

1998-01-01

Market research sources were used to initially gather primary technological problems and needs data from non-aerospace companies in targeted industry sectors. The company-supplied information served as input data to activate or start-up an internal, phased match-making process. This process was based on technical-level relationship exploration followed by business-level agreement negotiations, and culminated with project management and execution. Space Act Agreements represented near-term outputs. Company product or process commercialization derived from Lewis support and measurable economic effects represented far-term outputs.

Technology transfer within the government

NASA Technical Reports Server (NTRS)

Christensen, Carissa Bryce

1992-01-01

The report of a workshop panel concerned with technology transfer within the government is presented. The suggested subtopics for the panel were as follows: (1) transfer from non-NASA U.S. government technology developers to NASA space missions/programs; and (2) transfer from NASA to other U.S. government civil space mission programs. Two presentations were made to the panel: Roles/Value of Early Strategic Planning Within the Space Exploration Initiative (SEI) to Facilitate Later Technology Transfer To and From Industry; and NOAA Satellite Programs and Technology Requirements. The panel discussion addresses the following major issues: DOD/NASA cooperation; alternative mechanisms for interagency communication and interactions; current technology transfer relationships among federal research agencies, and strategies for improving this transfer; technology transfer mechanisms appropriate to intragovernment transfer; the importance of industry as a technology transfer conduit; and measures of merit.

48 CFR 970.2770-3 - Technology transfer and patent rights.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Technology transfer and....2770-3 Technology transfer and patent rights. The National Competitiveness Technology Transfer Act of 1989 (NCTTA) established technology transfer as a mission for Government-owned, contractor-operated...

48 CFR 970.2770-3 - Technology transfer and patent rights.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Technology transfer and....2770-3 Technology transfer and patent rights. The National Competitiveness Technology Transfer Act of 1989 (NCTTA) established technology transfer as a mission for Government-owned, contractor-operated...

48 CFR 970.2770-3 - Technology transfer and patent rights.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Technology transfer and....2770-3 Technology transfer and patent rights. The National Competitiveness Technology Transfer Act of 1989 (NCTTA) established technology transfer as a mission for Government-owned, contractor-operated...

48 CFR 970.2770-3 - Technology transfer and patent rights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Technology transfer and....2770-3 Technology transfer and patent rights. The National Competitiveness Technology Transfer Act of 1989 (NCTTA) established technology transfer as a mission for Government-owned, contractor-operated...

48 CFR 970.2770-3 - Technology transfer and patent rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Technology transfer and....2770-3 Technology transfer and patent rights. The National Competitiveness Technology Transfer Act of 1989 (NCTTA) established technology transfer as a mission for Government-owned, contractor-operated...

DESTINY

DOE Office of Scientific and Technical Information (OSTI.GOV)

2015-03-10

DESTINY is a comprehensive tool for modeling 3D and 2D cache designs using SRAM,embedded DRAM (eDRAM), spin transfer torque RAM (STT-RAM), resistive RAM (ReRAM), and phase change RAM (PCN). In its purpose, it is similar to CACTI, CACTI-3DD or NVSim. DESTINY is very useful for performing design-space exploration across several dimensions, such as optimizing for a target (e.g. latency, area or energy-delay product) for agiven memory technology, choosing the suitable memory technology or fabrication method (i.e. 2D v/s 3D) for a given optimization target, etc. DESTINY has been validated against several cache prototypes. DESTINY is expected to boost studies ofmore » next-generation memory architectures used in systems ranging from mobile devices to extreme-scale supercomputers.« less

Software engineering technology transfer: Understanding the process

NASA Technical Reports Server (NTRS)

Zelkowitz, Marvin V.

1993-01-01

Technology transfer is of crucial concern to both government and industry today. In this report, the mechanisms developed by NASA to transfer technology are explored and the actual mechanisms used to transfer software development technologies are investigated. Time, cost, and effectiveness of software engineering technology transfer is reported.

Self-pacing direct memory access data transfer operations for compute nodes in a parallel computer

DOEpatents

Blocksome, Michael A

2015-02-17

Methods, apparatus, and products are disclosed for self-pacing DMA data transfer operations for nodes in a parallel computer that include: transferring, by an origin DMA on an origin node, a RTS message to a target node, the RTS message specifying an message on the origin node for transfer to the target node; receiving, in an origin injection FIFO for the origin DMA from a target DMA on the target node in response to transferring the RTS message, a target RGET descriptor followed by a DMA transfer operation descriptor, the DMA descriptor for transmitting a message portion to the target node, the target RGET descriptor specifying an origin RGET descriptor on the origin node that specifies an additional DMA descriptor for transmitting an additional message portion to the target node; processing, by the origin DMA, the target RGET descriptor; and processing, by the origin DMA, the DMA transfer operation descriptor.

Innovative technology transfer of nondestructive evaluation research

Treesearch

Brian Brashaw; Robert J. Ross; Xiping Wang

2008-01-01

Technology transfer is often an afterthought for many nondestructive evaluation (NDE) researchers. Effective technology transfer should be considered during the planning and execution of research projects. This paper outlines strategies for using technology transfer in NDE research and presents a wide variety of technology transfer methods used by a cooperative...

Residue-and-polymer-free graphene transfer: DNA-CTMA/graphene/GaN bio-hybrid photodiode for light-sensitive applications

NASA Astrophysics Data System (ADS)

Reddy, M. Siva Pratap; Park, Herie; Lee, Jung-Hee

2018-02-01

In this work, we present a residue-and-polymer-free graphene transfer method by using the adhesive force between graphene and a target substrate, the hydrophobic property of graphene, and the surface tension of the solutions. We used an n-type GaN substrate as the target substrate to make a photodiode (PD). Recently, the inclusion of biomolecules in photodetection technology has attracted considerable attention in the electronics and photonics research, particularly due to the rapid evolution of organic-inorganic bio-hybrid PDs (Bio-HPDs). This report presents a significant photoresponse of the bioinspired graphene-based PD fabricated with deoxyribonucleic acid-cetyltrimetylammonium chloride (DNA-CTMA) biomolecules on the n-type GaN substrate. Bio-HPDs respond to the infrared, visible, and ultraviolet wavelengths. Moreover, the Bio-HPDs show photosensitivities (Iphoto/Idark) of 21, 143, and 1194 for infrared, visible, and ultraviolet wavebands, respectively, which can be attributed to the integration of high-mobility graphene and photosensitive DNA-CTMA biomolecules. In addition, the corresponding charge transfer mechanisms in the PDs are explained by energy band diagrams.

Retrovirus-based vectors for transient and permanent cell modification.

PubMed

Schott, Juliane W; Hoffmann, Dirk; Schambach, Axel

2015-10-01

Retroviral vectors are commonly employed for long-term transgene expression via integrating vector technology. However, three alternative retrovirus-based platforms are currently available that allow transient cell modification. Gene expression can be mediated from either episomal DNA or RNA templates, or selected proteins can be directly transferred through retroviral nanoparticles. The different technologies are functionally graded with respect to safety, expression magnitude and expression duration. Improvement of the initial technologies, including modification of vector designs, targeted increase in expression strength and duration as well as improved safety characteristics, has allowed maturation of retroviral systems into efficient and promising tools that meet the technological demands of a wide variety of potential application areas. Copyright © 2015 Elsevier Ltd. All rights reserved.

Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field.

PubMed

He, Zhi-Yao; Men, Ke; Qin, Zhou; Yang, Yang; Xu, Ting; Wei, Yu-Quan

2017-05-01

The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR-Cas9) system provides a novel genome editing technology that can precisely target a genomic site to disrupt or repair a specific gene. Some CRISPR-Cas9 systems from different bacteria or artificial variants have been discovered or constructed by biologists, and Cas9 nucleases and single guide RNAs (sgRNA) are the major components of the CRISPR-Cas9 system. These Cas9 systems have been extensively applied for identifying therapeutic targets, identifying gene functions, generating animal models, and developing gene therapies. Moreover, CRISPR-Cas9 systems have been used to partially or completely alleviate disease symptoms by mutating or correcting related genes. However, the efficient transfer of CRISPR-Cas9 system into cells and target organs remains a challenge that affects the robust and precise genome editing activity. The current review focuses on delivery systems for Cas9 mRNA, Cas9 protein, or vectors encoding the Cas9 gene and corresponding sgRNA. Non-viral delivery of Cas9 appears to help Cas9 maintain its on-target effect and reduce off-target effects, and viral vectors for sgRNA and donor template can improve the efficacy of genome editing and homology-directed repair. Safe, efficient, and producible delivery systems will promote the application of CRISPR-Cas9 technology in human gene therapy.

Training transfer: scientific background and insights for practical application.

PubMed

Issurin, Vladimir B

2013-08-01

Training transfer as an enduring, multilateral, and practically important problem encompasses a large body of research findings and experience, which characterize the process by which improving performance in certain exercises/tasks can affect the performance in alternative exercises or motor tasks. This problem is of paramount importance for the theory of training and for all aspects of its application in practice. Ultimately, training transfer determines how useful or useless each given exercise is for the targeted athletic performance. The methodological background of training transfer encompasses basic concepts related to transfer modality, i.e., positive, neutral, and negative; the generalization of training responses and their persistence over time; factors affecting training transfer such as personality, motivation, social environment, etc. Training transfer in sport is clearly differentiated with regard to the enhancement of motor skills and the development of motor abilities. The studies of bilateral skill transfer have shown cross-transfer effects following one-limb training associated with neural adaptations at cortical, subcortical, spinal, and segmental levels. Implementation of advanced sport technologies such as motor imagery, biofeedback, and exercising in artificial environments can facilitate and reinforce training transfer from appropriate motor tasks to targeted athletic performance. Training transfer of motor abilities has been studied with regard to contralateral effects following one limb training, cross-transfer induced by arm or leg training, the impact of strength/power training on the preparedness of endurance athletes, and the impact of endurance workloads on strength/power performance. The extensive research findings characterizing the interactions of these workloads have shown positive transfer, or its absence, depending on whether the combinations conform to sport-specific demands and physiological adaptations. Finally, cross-training as a form of concurrent exercising in different athletic disciplines has been examined in reference to the enhancement of general fitness, the preparation of recreational athletes, and the preparation of athletes for multi-sport activities such as triathlon, duathlon, etc.

Small Molecule Anti-cancer Agents that Stabilize the MYC-G-Quadruplex | NCI Technology Transfer Center | TTC

Cancer.gov

The proto-oncogene c-Myc is deregulated and overexpressed in ~70% of all cancers. Thus, c-Myc is an attractive therapeutic target. Beyond cancer, Myc is also a positive effector of tissue inflammation, and its function has been implicated in the pathophysiology of heart failure. Researchers at the National Cancer Institute (NCI) developed novel small molecules that target c-Myc at the transcriptional level, thus enabling a potential pan-cancer therapeutic. Specifically, these compounds stabilize the transcription repressing quadruplex in the c-Myc gene promoter region. The National Cancer Institute seeks parties interested in licensing or collaborative research to co-develop these therapeutic targets.'

ICAT and the NASA technology transfer process

NASA Technical Reports Server (NTRS)

Rifkin, Noah; Tencate, Hans; Watkins, Alison

1993-01-01

This paper will address issues related to NASA's technology transfer process and will cite the example of using ICAT technologies in educational tools. The obstacles to effective technology transfer will be highlighted, viewing the difficulties in achieving successful transfers of ICAT technologies.

Technology transfer from the viewpoint of a NASA prime contractor

NASA Technical Reports Server (NTRS)

Dyer, Gordon

1992-01-01

Viewgraphs on technology transfer from the viewpoint of a NASA prime contractor are provided. Technology Transfer Program for Manned Space Systems and the Technology Transfer Program status are addressed.

Benchmarking study of corporate research management and planning practices

NASA Astrophysics Data System (ADS)

McIrvine, Edward C.

1992-05-01

During 1983-84, Xerox Corporation was undergoing a change in corporate style through a process of training and altered behavior known as Leadership Through Quality. One tenet of Leadership Through Quality was benchmarking, a procedure whereby all units of the corporation were asked to compare their operation with the outside world. As a part of the first wave of benchmark studies, Xerox Corporate Research Group studied the processes of research management, technology transfer, and research planning in twelve American and Japanese companies. The approach taken was to separate `research yield' and `research productivity' (as defined by Richard Foster) and to seek information about how these companies sought to achieve high- quality results in these two parameters. The most significant findings include the influence of company culture, two different possible research missions (an innovation resource and an information resource), and the importance of systematic personal interaction between sources and targets of technology transfer.

Carbon Nanotube Arrays for Intracellular Delivery and Biological Applications

NASA Astrophysics Data System (ADS)

Golshadi, Masoud

Introducing nucleic acids into mammalian cells is a crucial step to elucidate biochemical pathways, modify gene expression in immortalized cells, primary cells, and stem cells, and intoduces new approaches for clinical diagnostics and therapeutics. Current gene transfer technologies, including lipofection, electroporation, and viral delivery, have enabled break-through advances in basic and translational science to enable derivation and programming of embryonic stem cells, advanced gene editing using CRISPR (Clustered regularly interspaced short palindromic repeats), and development of targeted anti-tumor therapy using chimeric antigen receptors in T-cells (CAR-T). Despite these successes, current transfection technologies are time consuming and limited by the inefficient introduction of test molecules into large populations of target cells, and the cytotoxicity of the techniques. Moreover, many cell types cannot be consistently transfected by lipofection or electroporation (stem cells, T-cells) and viral delivery has limitations to the size of experimental DNA that can be packaged. In this dissertation, a novel coverslip-like platform consisting of an array of aligned hollow carbon nanotubes (CNTs) embedded in a sacrificial template is developed that enhances gene transfer capabilities, including high efficiency, low toxicity, in an expanded range of target cells, with the potential to transfer mixed combinations of protein and nucleic acids. The CNT array devices are fabricated by a scalable template-based manufacturing method using commercially available membranes, eliminating the need for nano-assembly. High efficient transfection has been demonstrated by delivering various cargos (nanoparticles, dye and plasmid DNA) into populations of cells, achieving 85% efficiency of plasmid DNA delivery into immortalized cells. Moreover, the CNT-mediated transfection of stem cells shows 3 times higher efficiency compared to current lipofection methods. Evaluating the cell-CNT interaction elucidates the importance of the geometrical properties of CNT arrays (CNT exposed length and surface morphology) on transfection efficiency. The results indicate that densely-packed and shortly-exposed CNT arrays with planar surface will enhance gene delivery using this new platform. This technology offers a significant increase in efficiency and cell viability, along with the ease of use compared to current standard methods, which demonstrates its potential to accelerate the development of new cell models to study intractable diseases, decoding the signaling pathways, and drug discovery.

Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases.

PubMed

Xitong, Dang; Xiaorong, Zeng

2016-01-10

Exosomes are 30-120 nm membrane bound vesicles secreted naturally by almost all cells and exist in all body fluids. Accumulating evidence has shown that exosomes contain proteins, lipids, DNA, mRNA, miRNA, and lncRNA that can be transferred from producer cells to recipient cells, facilitating cell-cell communication. As the natural carrier of these signal molecules, exosomes possess many other properties such as stability, biocompatibility, biological barrier permeability, low toxicity, and low immunogenicity, which make them an attractive vehicle for therapeutic delivery. How exosomes target recipient cells in vivo remains largely unknown, however, exosomes are selectively enriched in some transmembrane proteins that can be genetically engineered to display ligands/homing peptides on their surface, which confers exosome targeting capability to cells bearing cognate receptors. With the discovery of many peptides homing to diseased tissues or organs through phage display and in vivo biopanning technologies, there is ample opportunity to explore the potential use of exosome for targeted gene therapy. Here, we briefly review exosome biogenesis, mechanisms of exosome-mediated cell–cell communication, and exosome isolation and purification methods, and specifically focus on the emerging exosome targeting technologies.

Balancing cellular redox metabolism in microbial electrosynthesis and electro fermentation - A chance for metabolic engineering.

PubMed

Kracke, Frauke; Lai, Bin; Yu, Shiqin; Krömer, Jens O

2018-01-01

More and more microbes are discovered that are capable of extracellular electron transfer, a process in which they use external electrodes as electron donors or acceptors for metabolic reactions. This feature can be used to overcome cellular redox limitations and thus optimizing microbial production. The technologies, termed microbial electrosynthesis and electro-fermentation, have the potential to open novel bio-electro production platforms from sustainable energy and carbon sources. However, the performance of reported systems is currently limited by low electron transport rates between microbes and electrodes and our limited ability for targeted engineering of these systems due to remaining knowledge gaps about the underlying fundamental processes. Metabolic engineering offers many opportunities to optimize these processes, for instance by genetic engineering of pathways for electron transfer on the one hand and target product synthesis on the other hand. With this review, we summarize the status quo of knowledge and engineering attempts around chemical production in bio-electrochemical systems from a microbe perspective. Challenges associated with the introduction or enhancement of extracellular electron transfer capabilities into production hosts versus the engineering of target compound synthesis pathways in natural exoelectrogens are discussed. Recent advances of the research community in both directions are examined critically. Further, systems biology approaches, for instance using metabolic modelling, are examined for their potential to provide insight into fundamental processes and to identify targets for metabolic engineering. Copyright © 2017 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

Communication and Cultural Change in University Technology Transfer

ERIC Educational Resources Information Center

Wright, David

2013-01-01

Faculty culture and communication networks are pivotal components of technology transfer on university campuses. Universities are focused upon diffusing technology to external clients and upon building structure and support systems to enhance technology transfer. However, engaging faculty members in technology transfer requires an internal…

KSC Tech Transfer News, Volume 5, No. 1

NASA Technical Reports Server (NTRS)

Buckingham, Bruce (Editor)

2012-01-01

In October 2011, the White House released a presidential memorandum titled "Accelerating Technology Transfer and Commercialization of Federal Research in Support of High-Growth Businesses." It emphasized the importance of technology transfer as a driver of successful innovation to fuel economic growth, create jobs, and make U.S. industries more competitive in a global market. In response to this memorandum, NASA developed a 5-year plan for accelerating its own technology transfer activities. This plan outlines key objectives for enhancing NASA's ability to increase the rate, volume, and quality of technology transfers to industry, academia, and other Government agencies. By doing so, we are increasing the economic impact and public benefit of Federal technology investments. In addition, NASA established technology transfer as a key element of one of its Agency High Priority Performance Goals: "Enable bold new missions and make new technologies available to Government agencies and U.S. industry."What does this mean to you? In the broadest sense, NASA defines technology transfer as the utilization of NASA's technological assets- technologies, innovations, unique facilities and equipment, and technical expertise- by public and private sectors to benefit the Nation. So, if your job involves developing new technologies, writing new software, creating innovative ways to do business, performing research, or developing new technical capabilities, you could be contributing to Kennedy Space Center's (KSC) technology transfer activities by creating the technological assets that may one day be used by external partners. Furthermore, anytime you provide technical expertise to external partners, you're participating in technology transfer. The single most important step you can take to support the technology transfer process is to report new technologies and innovations ro the Technology Transfer Office. This is the critical first step in fueling the technology transfer pipeline. This is also a requirement for all Federal employees (see NPD 2091.1 B) and most NASA contractors. Detailed information on when, where, and how ro report new technology is provided on the following page. In addition, it's important that all detailed-oriented discussions about technology between NASA and external partners are documented or that they occur under formal agreements such as Space Act Agreements and Nondisclosure Agreements. Our office can assist you in putting these agreements into place, protecting NASA's interests, and providing the means to accurately measure the Agency's technology transfer activities. Technology transfer is everyone's responsibility. We need your help to ensure that NASA remains the leader in Federal technology transfer, and that the great work done at KSC provides the maximum economic and societal benefit to the Nation.

Supporting Knowledge Transfer in IS Deployment Projects

NASA Astrophysics Data System (ADS)

Schönström, Mikael

To deploy new information systems is an expensive and complex task, and does seldom result in successful usage where the system adds strategic value to the firm (e.g. Sharma et al. 2003). It has been argued that innovation diffusion is a knowledge integration problem (Newell et al. 2000). Knowledge about business processes, deployment processes, information systems and technology are needed in a large-scale deployment of a corporate IS. These deployments can therefore to a large extent be argued to be a knowledge management (KM) problem. An effective deployment requires that knowledge about the system is effectively transferred to the target organization (Ko et al. 2005).

Urban development applications project. Urban technology transfer study

NASA Technical Reports Server (NTRS)

1975-01-01

Technology transfer is defined along with reasons for attempting to transfer technology. Topics discussed include theoretical models, stages of the innovation model, communication process model, behavior of industrial organizations, problem identification, technology search and match, establishment of a market mechanism, applications engineering, commercialization, and management of technology transfer.

Vaccines for HIV | NCI Technology Transfer Center | TTC

Cancer.gov

The development of an effective HIV vaccine has been an ongoing area of research. The high variability in HIV-1 virus strains has represented a major challenge in successful development. Ideally, an effective candidate vaccine would provide protection against the majority of clades of HIV. Two major hurdles to overcome are immunodominance and sequence diversity. This vaccine utilizes a strategy for overcoming these two issues by identifying the conserved regions of the virus and exploiting them for use in a targeted therapy. NCI seeks licensees and/or research collaborators to commercialize this technology, which has been validated in macaque models.

Technology transfer

NASA Technical Reports Server (NTRS)

Handley, Thomas

1992-01-01

The requirements for a successful technology transfer program and what such a program would look like are discussed. In particular, the issues associated with technology transfer in general, and within the Jet Propulsion Laboratory (JPL) environment specifically are addressed. The section on background sets the stage, identifies the barriers to successful technology transfer, and suggests actions to address the barriers either generally or specifically. The section on technology transfer presents a process with its supporting management plan that is required to ensure a smooth transfer process. Viewgraphs are also included.

Improving NASA's technology transfer process through increased screening and evaluation in the information dissemination program

NASA Technical Reports Server (NTRS)

Laepple, H.

1979-01-01

The current status of NASA's technology transfer system can be improved if the technology transfer process is better understood. This understanding will only be gained if a detailed knowledge about factors generally influencing technology transfer is developed, and particularly those factors affecting technology transfer from government R and D agencies to industry. Secondary utilization of aerospace technology is made more difficult because it depends on a transfer process which crosses established organizational lines of authority and which is outside well understood patterns of technical applications. In the absence of a sound theory about technology transfer and because of the limited capability of government agencies to explore industry's needs, a team approach to screening and evaluation of NASA generated technologies is proposed which calls for NASA, and other organizations of the private and public sectors which influence the transfer of NASA generated technology, to participate in a screening and evaluation process to determine the commercial feasibility of a wide range of technical applications.

Identification and evaluation of fluvial-dominated deltaic (Class I oil) reservoirs in Oklahoma. Quarterly technical progress report, July 1--September 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankin, C.J.; Banken, M.K.

The Oklahoma Geological Survey (OGS), the Geo Information Systems department, and the School of Petroleum and Geological Engineering at the University of Oklahoma are engaged in a program to identify and address Oklahoma`s oil recovery opportunities in fluvial-dominated deltaic (FDD) reservoirs. This program includes the systematic and comprehensive collection and evaluation of information on all of Oklahoma`s FDD reservoirs and the recovery technologies that have been (or could be) applied to those reservoirs with commercial success. This data collection and evaluation effort will be the foundation for an aggressive, multifaceted technology transfer program that is designed to support all ofmore » Oklahoma`s oil industry, with particular emphasis on smaller companies and independent operators in their attempts to maximize the economic producibility of FDD reservoirs. Specifically, this project will identify all FDD oil reservoirs in the State; group those reservoirs into plays that have similar depositional origins; collect, organize and analyze all available data conduct characterization and simulation studies on selected reservoirs in each play; and implement a technology transfer program targeted to the operators of FDD reservoirs. Activities were focused primarily on technology transfer elements of the project. This included regional play analysis and mapping, geologic field studies, and reservoir modeling for secondary water flood simulations as used in publication folios and workshops. The computer laboratory was fully operational for operator use. Computer systems design and database development activities were ongoing.« less

Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts

PubMed Central

Cartellieri, M; Feldmann, A; Koristka, S; Arndt, C; Loff, S; Ehninger, A; von Bonin, M; Bejestani, E P; Ehninger, G; Bachmann, M P

2016-01-01

The adoptive transfer of CD19-specific chimeric antigen receptor engineered T cells (CAR T cells) resulted in encouraging clinical trials in indolent B-cell malignancies. However, they also show the limitations of this fascinating technology: CAR T cells can lead to even life-threatening off-tumor, on-target side effects if CAR T cells crossreact with healthy tissues. Here, we describe a novel modular universal CAR platform technology termed UniCAR that reduces the risk of on-target side effects by a rapid and reversible control of CAR T-cell reactivity. The UniCAR system consists of two components: (1) a CAR for an inert manipulation of T cells and (2) specific targeting modules (TMs) for redirecting UniCAR T cells in an individualized time- and target-dependent manner. UniCAR T cells can be armed against different tumor targets simply by replacement of the respective TM for (1) targeting more than one antigen simultaneously or subsequently to enhance efficacy and (2) reducing the risk for development of antigen-loss tumor variants under treatment. Here we provide ‘proof of concept' for retargeting of UniCAR T cells to CD33- and/or CD123-positive acute myeloid leukemia blasts in vitro and in vivo. PMID:27518241

Benchmarking the Economic Impact and Effectiveness of University Technology Transfer in Maryland.

ERIC Educational Resources Information Center

Clinch, Richard

This study examined university technology transfer in Maryland in terms of three issues: (1) the economic impact of university technology transfer; (2) a comparison of the technology transfer effort of University of Maryland System (UMS) institutions with other regional and "best practice" institutions; and (3) the technology transfer…

Technology Transfer: A Case Study of Programs and Practices at NASA, DOD, DOC, and Academia

ERIC Educational Resources Information Center

Blood, John R.

2009-01-01

Technology transfer is vital to humanity. It spurs innovation, promotes commerce, and provides technology-based goods and services. Technology transfer is also highly complex and interdependent in nature. This interdependence is exemplified principally by the various technology transfer interactions between government, industry, and academia. …

Optimize Use of Space Research and Technology for Medical Devices

NASA Technical Reports Server (NTRS)

Minnifield, Nona K.

2012-01-01

systems, and cutting-edge component technologies to conduct a wide range of scientific observations and measurements. These technologies are also considered for practical applications that benefit society in remarkable ways. At NASA Goddard, the technology transfer initiative promotes matching technologies from Earth and space science needs to targeted industry sectors. This requires clear knowledge of industry needs and priorities and social demands. The process entails matching mature technologies where there are known innovation challenges and good opportunities for matching technology needs. This requires creative thinking and takes commitment of time and resources. Additionally, we also look at applications for known hot industry or societal needs. Doing so has given us occasion to host discussions with representatives from industry, academia, government organizations, and societal special interest groups about the application of NASA Goddard technologies for devices used in medical monitoring and detection tools. As a result, partnerships have been established. Innovation transpired when new products were enabled because of NASA Goddard research and technology programs.

Federal Technology Transfer Act Success Stories

EPA Pesticide Factsheets

Successful Federal Technology Transfer Act (FTTA) partnerships demonstrate the many advantages of technology transfer and collaboration. EPA and partner organizations create valuable and applicable technologies for the marketplace.

Evaluating Technology Transfer and Diffusion.

ERIC Educational Resources Information Center

Bozeman, Barry; And Others

1988-01-01

Four articles discuss the evaluation of technology transfer and diffusion: (1) "Technology Transfer at the U.S. National Laboratories: A Framework for Evaluation"; (2) "Application of Social Psychological and Evaluation Research: Lessons from Energy Information Programs"; (3) "Technology and Knowledge Transfer in Energy R and D Laboratories: An…

Technology Transfer Network and Affiliations

NASA Technical Reports Server (NTRS)

2003-01-01

The NASA Technology Transfer Partnership program sponsors a number of organizations around the country that are designed to assist U.S. businesses in accessing, utilizing, and commercializing NASA-funded research and technology. These organizations work closely with the Technology Transfer Offices, located at each of the 10 NASA field centers, providing a full range of technology transfer and commercialization services and assistance.

An Analysis of NASA Technology Transfer. Degree awarded by Pennsylvania State Univ.

NASA Technical Reports Server (NTRS)

Bush, Lance B.

1996-01-01

A review of previous technology transfer metrics, recommendations, and measurements is presented within the paper. A quantitative and qualitative analysis of NASA's technology transfer efforts is performed. As a relative indicator, NASA's intellectual property performance is benchmarked against a database of over 100 universities. Successful technology transfer (commercial sales, production savings, etc.) cases were tracked backwards through their history to identify the key critical elements that lead to success. Results of this research indicate that although NASA's performance is not measured well by quantitative values (intellectual property stream data), it has a net positive impact on the private sector economy. Policy recommendations are made regarding technology transfer within the context of the documented technology transfer policies since the framing of the Constitution. In the second thrust of this study, researchers at NASA Langley Research Center were surveyed to determine their awareness of, attitude toward, and perception about technology transfer. Results indicate that although researchers believe technology transfer to be a mission of the Agency, they should not be held accountable or responsible for its performance. In addition, the researchers are not well educated about the mechanisms to perform, or policies regarding, technology transfer.

Software Engineering Technology Infusion Within NASA

NASA Technical Reports Server (NTRS)

Zelkowitz, Marvin V.

1996-01-01

Abstract technology transfer is of crucial concern to both government and industry today. In this paper, several software engineering technologies used within NASA are studied, and the mechanisms, schedules, and efforts at transferring these technologies are investigated. The goals of this study are: 1) to understand the difference between technology transfer (the adoption of a new method by large segments of an industry) as an industry-wide phenomenon and the adoption of a new technology by an individual organization (called technology infusion); and 2) to see if software engineering technology transfer differs from other engineering disciplines. While there is great interest today in developing technology transfer models for industry, it is the technology infusion process that actually causes changes in the current state of the practice.

CRISPRi-sRNA: Transcriptional-Translational Regulation of Extracellular Electron Transfer in Shewanella oneidensis.

PubMed

Cao, Yingxiu; Li, Xiaofei; Li, Feng; Song, Hao

2017-09-15

Extracellular electron transfer (EET) in Shewanella oneidensis MR-1, which is one of the most well-studied exoelectrogens, underlies many microbial electrocatalysis processes, including microbial fuel cells, microbial electrolysis cells, and microbial electrosynthesis. However, regulating the efficiency of EET remains challenging due to the lack of efficient genome regulation tools that regulate gene expression levels in S. oneidensis. Here, we systematically established a transcriptional regulation technology, i.e., clustered regularly interspaced short palindromic repeats interference (CRISPRi), in S. oneidensis MR-1 using green fluorescent protein (GFP) as a reporter. We used this CRISPRi technology to repress the expression levels of target genes, individually and in combination, in the EET pathways (e.g., the MtrCAB pathway and genes affecting the formation of electroactive biofilms in S. oneidensis), which in turn enabled the efficient regulation of EET efficiency. We then established a translational regulation technology, i.e., Hfq-dependent small regulatory RNA (sRNA), in S. oneidensis by repressing the GFP reporter and mtrA, which is a critical gene in the EET pathways in S. oneidensis. To achieve coordinated transcriptional and translational regulation at the genomic level, the CRISPRi and Hfq-dependent sRNA systems were incorporated into a single plasmid harbored in a recombinant S. oneidensis strain, which enabled an even higher efficiency of mtrA gene repression in the EET pathways than that achieved by the CRISPRi and Hfq-dependent sRNA system alone, as exhibited by the reduced electricity output. Overall, we developed a combined CRISPRi-sRNA method that enabled the synergistic transcriptional and translational regulation of target genes in S. oneidensis. This technology involving CRISPRi-sRNA transcriptional-translational regulation of gene expression at the genomic level could be applied to other microorganisms.

Optimizing Outcome in the University-Industry Technology Transfer Projects

NASA Astrophysics Data System (ADS)

Alavi, Hamed; Hąbek, Patrycja

2016-06-01

Transferring inventions of academic scientists to private enterprises for the purpose of commercialization is long known as University-Industry (firm) Technology Transfer While the importance of this phenomenon is simultaneously raising in public and private sector, only a part of patented academic inventions succeed in passing the process of commercialization. Despite the fact that formal Technology Transfer process and licencing of patented innovations to third party is the main legal tool for safeguarding rights of academic inventors in commercialization of their inventions, it is not sufficient for transmitting tacit knowledge which is necessary in exploitation of transferred technology. Existence of reciprocal and complementary relations between formal and informal technology transfer process has resulted in formation of different models for university-industry organizational collaboration or even integration where licensee firms keep contact with academic inventors after gaining legal right for commercialization of their patented invention. Current paper argues that despite necessity for patents to legally pass the right of commercialization of an invention, they are not sufficient for complete knowledge transmission in the process of technology transfer. Lack of efficiency of formal mechanism to end the Technology Transfer loop makes an opportunity to create innovative interpersonal and organizational connections among patentee and licensee company. With emphasize on need for further elaboration of informal mechanisms as critical and underappreciated aspect of technology transfer process, article will try to answer the questions of how to optimize knowledge transmission process in the framework of University-Industry Technology Transfer Projects? What is the theoretical basis for university-industry technology transfer process? What are organization collaborative models which can enhance overall performance by improving transmission of knowledge in University- Firm Technology Transfer process?

48 CFR 970.5227-3 - Technology transfer mission.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Technology transfer... for Management and Operating Contracts 970.5227-3 Technology transfer mission. As prescribed in 48 CFR 970.2770-4(a), insert the following clause: Technology Transfer Mission (AUG 2002) This clause has as...

48 CFR 970.5227-3 - Technology transfer mission.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Technology transfer... for Management and Operating Contracts 970.5227-3 Technology transfer mission. As prescribed in 48 CFR 970.2770-4(a), insert the following clause: Technology Transfer Mission (AUG 2002) This clause has as...

48 CFR 970.5227-3 - Technology transfer mission.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Technology transfer... for Management and Operating Contracts 970.5227-3 Technology transfer mission. As prescribed in 48 CFR 970.2770-4(a), insert the following clause: Technology Transfer Mission (AUG 2002) This clause has as...

48 CFR 970.5227-3 - Technology transfer mission.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Technology transfer... for Management and Operating Contracts 970.5227-3 Technology transfer mission. As prescribed in 48 CFR 970.2770-4(a), insert the following clause: Technology Transfer Mission (AUG 2002) This clause has as...

Three CCR accomplishments receive Excellence in Technology Transfer Awards | Center for Cancer Research

Cancer.gov

The Federal Laboratory Consortium for Technology Transfer has recognized three CCR accomplishments with Excellence in Technology Transfer Awards. This award category honors employees of FLC member laboratories and non-laboratory staff who have accomplished outstanding work in the process of transferring federally developed technology. Read more…

TTC Fellowship Program | NCI Technology Transfer Center | TTC

Cancer.gov

The TTC has fellowship opportunities available to qualified candidates in the field of technology transfer. This Fellowship starts with your science, legal, and/or business background to create a new competency in technology transfer, preparing you for technology transfer positions within academia, industry, or the federal government.

The Change Book: A Blueprint for Technology Transfer.

ERIC Educational Resources Information Center

Addiction Technology Transfer Centers.

This document was developed by the Addiction Technology Transfer Center (ATTC) National Network to improve understanding about how valuable effective technology transfer is to the fields of substance abuse treatment and prevention. Technology transfer involves creating a mechanism by which a desired change is accepted, incorporated, and reinforced…

76 FR 71048 - Sixth Annual Philip S. Chen, Jr. Distinguished Lecture on Innovation and Technology Transfer

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

..., Jr. Distinguished Lecture on Innovation and Technology Transfer AGENCY: National Institutes of Health... sixth annual Philip S. Chen, Jr., Ph.D. Distinguished Lecture on Innovation and Technology Transfer... present ``Treatment of Cancer with Recombinant Immunotoxins: From Technology Transfer to the Patient.'' Dr...

48 CFR 970.5227-3 - Technology transfer mission.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Technology transfer... for Management and Operating Contracts 970.5227-3 Technology transfer mission. As prescribed in 48 CFR 970.2770-4(a), insert the following clause: Technology Transfer Mission (AUG 2002) This clause has as...

Welcome to Ames Research Center (1987 forum on Federal technology transfer)

NASA Technical Reports Server (NTRS)

Ballhaus, William F., Jr.

1988-01-01

NASA Ames Research Center has a long and distinguished history of technology development and transfer. Recently, in a welcoming speech to the Forum on Federal Technology Transfer, Director Ballhouse of Ames described significant technologies which have been transferred from Ames to the private sector and identifies future opportunities.

LEO to GEO (and Beyond) Transfers Using High Power Solar Electric Propulsion (HP-SEP)

NASA Technical Reports Server (NTRS)

Loghry, Christopher S.; Oleson, Steven R.; Woytach, Jeffrey M.; Martini, Michael C.; Smith, David A.; Fittje, James E.; Gyekenyesi, John Z.; Colozza, Anthony J.; Fincannon, James; Bogner, Aimee;

The role of the University Licensing Office in transferring intellectual property to industry

NASA Technical Reports Server (NTRS)

Preston, John T.

1992-01-01

Universities in the US have a significant impact on business through the transfer of technology. This transfer of technology takes various forms, including faculty communications, faculty consulting activities, and the direct transfer of technology through the licensing of patents, copyrights, and other intellectual property to industry. The topics discussed include the following: background of the MIT Technology Licensing Office (TLO), goals of the MIT TLO, MIT's technology transfer philosophy, and important factors for success in new company formation.

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles.

PubMed

Yu, Kyung-Rok; Natanson, Hannah; Dunbar, Cynthia E

2016-10-01

Hematopoietic stem and progenitor cells (HSPCs) have great therapeutic potential because of their ability to both self-renew and differentiate. It has been proposed that, given their unique properties, a small number of genetically modified HSPCs could accomplish lifelong, corrective reconstitution of the entire hematopoietic system in patients with various hematologic disorders. Scientists have demonstrated that gene addition therapies-targeted to HSPCs and using integrating retroviral vectors-possess clear clinical benefits in multiple diseases, among them immunodeficiencies, storage disorders, and hemoglobinopathies. Scientists attempting to develop clinically relevant gene therapy protocols have, however, encountered a number of unexpected hurdles because of their incomplete knowledge of target cells, genomic control, and gene transfer technologies. Targeted gene-editing technologies using engineered nucleases such as ZFN, TALEN, and/or CRISPR/Cas9 RGEN show great clinical promise, allowing for the site-specific correction of disease-causing mutations-a process with important applications in autosomal dominant or dominant-negative genetic disorders. The relative simplicity of the CRISPR/Cas9 system, in particular, has sparked an exponential increase in the scientific community's interest in and use of these gene-editing technologies. In this minireview, we discuss the specific applications of gene-editing technologies in human HSPCs, as informed by prior experience with gene addition strategies. HSPCs are desirable but challenging targets; the specific mechanisms these cells evolved to protect themselves from DNA damage render them potentially more susceptible to oncogenesis, especially given their ability to self-renew and their long-term proliferative potential. We further review scientists' experience with gene-editing technologies to date, focusing on strategies to move these techniques toward implementation in safe and effective clinical trials.

Controlling data transfers from an origin compute node to a target compute node

DOEpatents

Archer, Charles J [Rochester, MN; Blocksome, Michael A [Rochester, MN; Ratterman, Joseph D [Rochester, MN; Smith, Brian E [Rochester, MN

2011-06-21

Methods, apparatus, and products are disclosed for controlling data transfers from an origin compute node to a target compute node that include: receiving, by an application messaging module on the target compute node, an indication of a data transfer from an origin compute node to the target compute node; and administering, by the application messaging module on the target compute node, the data transfer using one or more messaging primitives of a system messaging module in dependence upon the indication.

External Heat Transfer Coefficient Measurements on a Surrogate Indirect Inertial Confinement Fusion Target

DOE PAGES

Miles, Robin; Havstad, Mark; LeBlanc, Mary; ...

2015-09-15

External heat transfer coefficients were measured around a surrogate Indirect inertial confinement fusion (ICF) based on the Laser Inertial Fusion Energy (LIFE) design target to validate thermal models of the LIFE target during flight through a fusion chamber. Results indicate that heat transfer coefficients for this target 25-50 W/m 2∙K are consistent with theoretically derived heat transfer coefficients and valid for use in calculation of target heating during flight through a fusion chamber.

Strategic directions and mechanisms in technology transfer

NASA Technical Reports Server (NTRS)

Mackin, Robert

1992-01-01

An outline summarizing the Working Panel discussion related to strategic directions for technology transfer is presented. Specific topics addressed include measuring success, management of technology, innovation and experimentation in the tech transfer process, integration of tech transfer into R&D planning, institutionalization of tech transfer, and policy/legislative resources.

23 CFR 420.205 - What is the FHWA's policy for research, development, and technology transfer funding?

Code of Federal Regulations, 2012 CFR

2012-04-01

... technology transfer funding? 420.205 Section 420.205 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Technology Transfer Program Management § 420.205 What is the FHWA's policy for research, development, and technology transfer funding? (a) It is the FHWA's policy to administer the RD&T program activities utilizing...

23 CFR 420.205 - What is the FHWA's policy for research, development, and technology transfer funding?

Code of Federal Regulations, 2013 CFR

2013-04-01

... technology transfer funding? 420.205 Section 420.205 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Technology Transfer Program Management § 420.205 What is the FHWA's policy for research, development, and technology transfer funding? (a) It is the FHWA's policy to administer the RD&T program activities utilizing...

23 CFR 420.205 - What is the FHWA's policy for research, development, and technology transfer funding?

Code of Federal Regulations, 2010 CFR

2010-04-01

... technology transfer funding? 420.205 Section 420.205 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Technology Transfer Program Management § 420.205 What is the FHWA's policy for research, development, and technology transfer funding? (a) It is the FHWA's policy to administer the RD&T program activities utilizing...

23 CFR 420.205 - What is the FHWA's policy for research, development, and technology transfer funding?

Code of Federal Regulations, 2014 CFR

2014-04-01

... technology transfer funding? 420.205 Section 420.205 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Technology Transfer Program Management § 420.205 What is the FHWA's policy for research, development, and technology transfer funding? (a) It is the FHWA's policy to administer the RD&T program activities utilizing...

23 CFR 420.205 - What is the FHWA's policy for research, development, and technology transfer funding?

Code of Federal Regulations, 2011 CFR

2011-04-01

... technology transfer funding? 420.205 Section 420.205 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Technology Transfer Program Management § 420.205 What is the FHWA's policy for research, development, and technology transfer funding? (a) It is the FHWA's policy to administer the RD&T program activities utilizing...

Dissemination of CERN's Technology Transfer: Added Value from Regional Transfer Agents

ERIC Educational Resources Information Center

Hofer, Franz

2005-01-01

Technologies developed at CERN, the European Organization for Nuclear Research, are disseminated via a network of external technology transfer officers. Each of CERN's 20 member states has appointed at least one technology transfer officer to help establish links with CERN. This network has been in place since 2001 and early experiences indicate…

TARGET/CRYOCHIL - THERMODYNAMIC ANALYSIS AND SUBSCALE MODELING OF SPACE-BASED ORBIT TRANSFER VEHICLE CRYOGENIC PROPELLANT RESUPPLY

NASA Technical Reports Server (NTRS)

Defelice, D. M.

1994-01-01

The resupply of the cryogenic propellants is an enabling technology for space-based transfer vehicles. As part of NASA Lewis's ongoing efforts in micro-gravity fluid management, thermodynamic analysis and subscale modeling techniques have been developed to support an on-orbit test bed for cryogenic fluid management technologies. These efforts have been incorporated into two FORTRAN programs, TARGET and CRYOCHIL. The TARGET code is used to determine the maximum temperature at which the filling of a given tank can be initiated and subsequently filled to a specified pressure and fill level without venting. The main process is the transfer of the energy stored in the thermal mass of the tank walls into the inflowing liquid. This process is modeled by examining the end state of the no-vent fill process. This state is assumed to be at thermal equilibrium between the tank and the fluid which is well mixed and saturated at the tank pressure. No specific assumptions are made as to the processes or the intermediate thermodynamic states during the filling. It is only assumed that the maximum tank pressure occurs at the final state. This assumption implies that, during the initial phases of the filling, the injected liquid must pass through the bulk vapor in such a way that it absorbs a sufficient amount of its superheat so that moderate tank pressures can be maintained. It is believed that this is an achievable design goal for liquid injection systems. TARGET can be run with any fluid for which the user has a properties data base. Currently it will only run for hydrogen, oxygen, and nitrogen since pressure-enthalpy data sets have been included for these fluids only. CRYOCHIL's primary function is to predict the optimum liquid charge to be injected for each of a series of charge-hold-vent chilldown cycles. This information can then be used with specified mass flow rates and valve response times to control a liquid injection system for tank chilldown operations. This will insure that the operations proceed quickly and efficiently. These programs are written in FORTRAN for batch execution on IBM 370 class mainframe computers. It requires 360K of RAM for execution. The standard distribution medium for this program is a 1600 BPI 9track magnetic tape in EBCDIC format. TARGET/CRYOCHIL was developed in 1988.

SmallSats, Iodine Propulsion Technology, Applications to Low-Cost Lunar Missions, and the Iodine Satellite (iSAT) Project

NASA Technical Reports Server (NTRS)

Dankanich, John W.

2014-01-01

Closing Remarks: ?(1) SmallSats hold significant potential for future low cost high value missions; (2) Propulsion remains a key limiting capability for SmallSats that Iodine can address: High ISP * Density for volume constrained spacecraft; Indefinite quiescence, unpressurized and non-hazardous as a secondary payload; (3) Iodine enables MicroSat and SmallSat maneuverability: Enables transfer into high value orbits, constellation deployment and deorbit; (4) Iodine may enable a new class of planetary and exploration class missions: Enables GTO launched secondary spacecraft to transit to the moon, asteroids, and other interplanetary destinations for approximately 150 million dollars full life cycle cost including the launch; (5) ESPA based OTVs are also volume constrained and a shift from xenon to iodine can significantly increase the transfer vehicle change in volume capability including transfers from GTO to a range of Lunar Orbits; (6) The iSAT project is a fast pace high value iodine Hall technology demonstration mission: Partnership with NASA GRC and NASA MSFC with industry partner - Busek; (7) The iSAT mission is an approved project with PDR in November of 2014 and is targeting a flight opportunity in FY17.

Technology transfer needs and experiences: The NASA Research Center perspective

NASA Technical Reports Server (NTRS)

Gross, Anthony R.

1992-01-01

Viewgraphs on technology transfer needs and experiences - the NASA Research Center perspective are provided. Topics covered include: functions of NASA, incentives and benefits, technology transfer mechanisms, economics of technology commercialization, examples, and conclusions.

Technology transfer

NASA Technical Reports Server (NTRS)

Penaranda, Frank E.

1992-01-01

The topics are presented in viewgraph form and include the following: international comparison of R&D expenditures in 1989; NASA Technology Transfer Program; NASA Technology Utilization Program thrusts for FY 1992 and FY 1993; National Technology Transfer Network; and NTTC roles.

A continuing program for technology transfer to the apparel industry

NASA Technical Reports Server (NTRS)

Clingman, W. H.

1971-01-01

A six month program has been carried out to investigate various mechanisms for transferring technology to industry. This program has focused on transfer to the apparel industry through the Apparel Research Foundation. The procedure was to analyze the problem, obtain potentially relevant aerospace technology, and then transfer this technology to the industry organization. This was done in a specific case. Technology was identified relevant to stitchless joining, and this technology was transferred to the Apparel Research Foundation. The feasibility and ground rules for carrying out such activities on a broader scale were established. A specific objective was to transfer new technology from the industry organization to the industry itself. This required the establishment of an application engineering program. Another transfer mechanism tested was publication of solutions to industry problems in a format familiar to the industry. This is to be distinguished from circulating descriptions of new technology. Focus is on the industry problem and the manager is given a formula for solving it that he can follow. It was concluded that this mechanism can complement the problem statement approach to technology transfer. It is useful in achieving transfer when a large amount of application engineering is not necessary. A wide audience is immediately exposed to the technology. On the other hand, the major manufacturing problems which require a sophisticated technical solution integrating many innovations are less likely to be helped.

Magnetic nanoparticles: Applications in gene delivery and gene therapy.

PubMed

Majidi, Sima; Zeinali Sehrig, Fatemeh; Samiei, Mohammad; Milani, Morteza; Abbasi, Elham; Dadashzadeh, Kianoosh; Akbarzadeh, Abolfazl

2016-06-01

Gene therapy is defined as the direct transfer of genetic material to tissues or cells for the treatment of inherited disorders and acquired diseases. For gene delivery, magnetic nanoparticles (MNPs) are typically combined with a delivery platform to encapsulate the gene, and promote cell uptake. Delivery technologies that have been used with MNPs contain polymeric, viral, as well as non-viral platforms. In this review, we focus on targeted gene delivery using MNPs.

Technology Transfer/A Case Study: Target Strength

DTIC Science & Technology

1974-03-01

Computer, 1 972] are both correct . The first man, a former newspaper writer, credits the intense rate of change now being experienced in society to a...inasmuch as it fails to account for certain diffrac- L tion phenomena; and it will give correct results only for cases where these diffraction...mentioned above, the Luneburg -iline result of Eq. (2,2-49) should be correct as the paraboloid represents an infinite body which does not support

Abstract to Action: Targeted Learning System Theory Applied to Adaptive Flight Training

DTIC Science & Technology

2018-04-18

complete the VRLE trained task in the real world confirming a good transfer of spatial knowledge from VR to reality.39 A VRLE was also used in a...opportunities if the technology was customized to produce the necessary datasets for the required education or training outcomes. The TLST maximizes...the simulator staging area to confirm your Virtual Reality training times. Good Luck! ` 92 Pre-Virtual Reality (VR) Instructions You are

Immunogenic Antigen Selective Cancer Immunotherapy | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at the National Institute on Aging working on cancer immunotherapy and detection report the use of SPANX-B polypeptides in the treatment and identification of cancer. Specific human malignancies targeted for the treatments disclosed include melanoma and lung, colon, renal, ovarian and breast carcinomas. The NIA seeks parties interested in licensing or collaborative research to further develop, evaluate, or commercialize SPANX-B polypeptides in the treatment and identification of cancer.

TECHNOLOGY TRANSFER TO U.S. INDEPENDENT OIL AND NATURAL GAS PRODUCERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donald Duttlinger

2001-11-01

The Petroleum Technology Transfer Council (PTTC) continued pursuing its mission of helping U.S. independent oil and gas producers make timely, informed technology decisions during Fiscal Year 2001 (FY01). Functioning as a cohesive national organization, PTTC has active grassroots programs through its ten Regional Lead Organizations (RLOs). They bring research and academia to the table via their association with geological surveys and engineering departments. The regional directors interact with independent oil and gas producers through technology workshops, resource centers, websites, newsletters, various technical publications and other outreach efforts. These are guided by regional Producer Advisory Groups (PAGs), who are area operatorsmore » and service companies working with the regional networks. The role of the national Headquarters (HQ) staff includes planning and managing the PTTC program, conducting nation wide technology transfer activities, and implementing a comprehensive communications effort. The organization effectively combines federal funding through the Department of Energy's (DOE) Office of Fossil Energy, state, and industry funding to achieve important goals for all of these sectors. This integrated funding base, combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff, are achieving notable results. PTTC is increasingly recognized as a critical resource for information and access to technologies, especially for smaller companies without direct contact to R&D efforts. This technical progress report summarizes PTTC's accomplishments during FY01, which lays the groundwork for further growth in the future. At a time of many industry changes and wide market movements, the organization itself is adapting to change. PTTC has built a reputation and expectation among producers and other industry participants to quickly distribute information addressing technical needs. The organization efficiently has an impact on business economics as the focus remains on proven applicable technologies, which target cost reduction and efficiency gains.« less

Technology transfer for adaptation

NASA Astrophysics Data System (ADS)

Biagini, Bonizella; Kuhl, Laura; Gallagher, Kelly Sims; Ortiz, Claudia

2014-09-01

Technology alone will not be able to solve adaptation challenges, but it is likely to play an important role. As a result of the role of technology in adaptation and the importance of international collaboration for climate change, technology transfer for adaptation is a critical but understudied issue. Through an analysis of Global Environment Facility-managed adaptation projects, we find there is significantly more technology transfer occurring in adaptation projects than might be expected given the pessimistic rhetoric surrounding technology transfer for adaptation. Most projects focused on demonstration and early deployment/niche formation for existing technologies rather than earlier stages of innovation, which is understandable considering the pilot nature of the projects. Key challenges for the transfer process, including technology selection and appropriateness under climate change, markets and access to technology, and diffusion strategies are discussed in more detail.

The application of the high throughput sequencing technology in the transposable elements.

PubMed

Liu, Zhen; Xu, Jian-hong

2015-09-01

High throughput sequencing technology has dramatically improved the efficiency of DNA sequencing, and decreased the costs to a great extent. Meanwhile, this technology usually has advantages of better specificity, higher sensitivity and accuracy. Therefore, it has been applied to the research on genetic variations, transcriptomics and epigenomics. Recently, this technology has been widely employed in the studies of transposable elements and has achieved fruitful results. In this review, we summarize the application of high throughput sequencing technology in the fields of transposable elements, including the estimation of transposon content, preference of target sites and distribution, insertion polymorphism and population frequency, identification of rare copies, transposon horizontal transfers as well as transposon tagging. We also briefly introduce the major common sequencing strategies and algorithms, their advantages and disadvantages, and the corresponding solutions. Finally, we envision the developing trends of high throughput sequencing technology, especially the third generation sequencing technology, and its application in transposon studies in the future, hopefully providing a comprehensive understanding and reference for related scientific researchers.

15 CFR 740.15 - Aircraft and vessels (AVS).

Code of Federal Regulations, 2011 CFR

2011-01-01

... transfer of technology. No technology is transferred to a national of a destination in Country Group E:1... destination in Country Group E:1 (see supplement No. 1 to this part); (vi) Technology is not transferred to a... destination in Country Group E:1 (see supplement No. 1 to this part); (vi) Technology is not transferred to a...

NREL Solar Cell Wins Federal Technology Transfer Prize | News | NREL

Science.gov Websites

Solar Cell Wins Federal Technology Transfer Prize News Release: NREL Solar Cell Wins Federal ) Solar Cell was named a winner of the 2009 Award for Excellence in Technology Transfer by the Federal Laboratory Consortium for Technology Transfer. The original IMM cell was invented by Mark Wanlass of NREL's

48 CFR 970.3102-05-30-70 - Patent costs and technology transfer costs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... technology transfer costs. 970.3102-05-30-70 Section 970.3102-05-30-70 Federal Acquisition Regulations System... Principles and Procedures 970.3102-05-30-70 Patent costs and technology transfer costs. (a) For management and operating contracts that do not include the clause at 970.5227-3, Technology Transfer Mission, the...

48 CFR 970.3102-05-30-70 - Patent costs and technology transfer costs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... technology transfer costs. 970.3102-05-30-70 Section 970.3102-05-30-70 Federal Acquisition Regulations System... Principles and Procedures 970.3102-05-30-70 Patent costs and technology transfer costs. (a) For management and operating contracts that do not include the clause at 970.5227-3, Technology Transfer Mission, the...

48 CFR 970.3102-05-30-70 - Patent costs and technology transfer costs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... technology transfer costs. 970.3102-05-30-70 Section 970.3102-05-30-70 Federal Acquisition Regulations System... Principles and Procedures 970.3102-05-30-70 Patent costs and technology transfer costs. (a) For management and operating contracts that do not include the clause at 970.5227-3, Technology Transfer Mission, the...

48 CFR 970.3102-05-30-70 - Patent costs and technology transfer costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technology transfer costs. 970.3102-05-30-70 Section 970.3102-05-30-70 Federal Acquisition Regulations System... Principles and Procedures 970.3102-05-30-70 Patent costs and technology transfer costs. (a) For management and operating contracts that do not include the clause at 970.5227-3, Technology Transfer Mission, the...

Environmentally Conscious Manufacturing Technology Transfer and Training Initiative (ECMT3I) Technology Transfer Model Report.

ERIC Educational Resources Information Center

Sandia National Labs., Albuquerque, NM.

The Environmentally Conscious Manufacturing Technology Transfer and Training Initiative (ECMT3I) is a cooperative effort among education and research institutions in New Mexico to analyze problems in transferring environmental technologies from Department of Energy laboratories to small and medium enterprises (SME's). The goal of the ECMT3I is to…

48 CFR 970.3102-05-30-70 - Patent costs and technology transfer costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technology transfer costs. 970.3102-05-30-70 Section 970.3102-05-30-70 Federal Acquisition Regulations System... Principles and Procedures 970.3102-05-30-70 Patent costs and technology transfer costs. (a) For management and operating contracts that do not include the clause at 970.5227-3, Technology Transfer Mission, the...

Tech Transfer News. Volume 6, No. 1

NASA Technical Reports Server (NTRS)

Victor, Megan E.

2014-01-01

On October 28, 2011, the White House released a Presidential Memorandum entitled: Accelerating Technology Transfer and Commercialization of Federal Research in Support of High-Growth Businesses. With this memo, the President challenged all federal agencies conducting R&D to accelerate technology transfer and commercialization of federally developed technology to help stimulate the national economy. The NASA Technology Transfer Program responded by asking the center technology transfer offices to reach out to - and work more closely with - their regional economic development organizations to promote the transfer of NASA technologies to the local private sector for use in the marketplace. Toward that effort, the KSC Technology Transfer Office teamed with the Florida Space Coast Economic Development Commission (EDC) to host a technology transfer forum designed to increase our business community's awareness of available KSC technologies for transfer. In addition, the forum provided opportunities for commercial businesses to collaborate with KSC in technology development. (see article on page 12) The forum, held on September 12, 2013, focused on KSC technology transfer and partnership opportunities within the Robotics, Sustainability, Information Technology and Environmental Remediation technology areas. The event was well attended with over 120 business leaders from the community. KSC Center Director Robert Cabana and the Center Chief Technologist Karen Thompson provided remarks, and several KSC lead researchers presented technical information and answered questions, which were not in short supply. Florida Today and the Orlando Sentinel ran news stories on the forum and both NASA TV and Channel 6 News filmed portions of the event. Given the reaction by the media and local business to the forum, it is evident the community is recognizing the opportunities that NASA-developed technologies can provide to aspiring entrepreneurs and existing companies to bring new technologies to market, as well as the positive impact KSC technology transfer can have on the local economy. We see even more evidence of this in the efforts by several other organizations to develop programs that provide aspiring entrepreneurs with the opportunity and training needed to identify the commercial potential of specific NASA technologies and develop business plans to exploit that potential. Several initiatives include Florida Startup Quest, CareerSource Brevard Energy Launch, Rollins College Entrepreneurial Scholar of Distinction Program, and a new effort led by the University of Central Florida Office of Research and Commercialization to stimulate new business growth in Florida based on NASA technologies. The KSC Technology Transfer Office has stepped up to support each of these programs and is providing them with the NASA technologies they need to help move the economy forward.

Identification and evaluation of fluvial-dominated deltaic (Class 1 oil) reservoirs in Oklahoma. Quarterly technical progress report, January 1, 1995--March 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankin, C.J.; Banken, M.K.

The Oklahoma Geological Survey (OGS), the Geological Information Systems department, and the School of Petroleum and Geological Engineering at the University of Oklahoma are engaging in a program to identify and address Oklahoma`s oil recovery opportunities in fluvial-dominated deltaic (FDD) reservoirs. This program includes the systematic and comprehensive collection and evaluation of information on all of Oklahoma`s FDD reservoirs and the recovery technologies that have been (or could be) applied to those reservoirs with commercial success. This data collection and evaluation effort will be the foundation for an aggressive, multifaceted technology transfer program that is designed to support all ofmore » Oklahoma`s oil industry, with particular emphasis on smaller companies and independent operators in their attempts to maximize the economic producibility of FDD reservoirs. Specifically, this project will identify all FDD oil reservoirs in the State; group those reservoirs into plays that have similar depositional and subsequent geologic histories; collect, organize and analyze all available data; conduct characterization and simulation studies on selected reservoirs in each play; and implement a technology transfer program targeted to the operators of FDD reservoirs to sustain the life expectancy of existing wells with the ultimate objective of increasing oil recovery. The elements of the technology transfer program include developing and publishing play portfolios, holding workshops to release play analyses and identify opportunities in each of the plays, and establishing a computer laboratory that is available for industry users.« less

Technology transfer: Imaging tracker to robotic controller

NASA Technical Reports Server (NTRS)

Otaguro, M. S.; Kesler, L. O.; Land, Ken; Erwin, Harry; Rhoades, Don

1988-01-01

The transformation of an imaging tracker to a robotic controller is described. A multimode tracker was developed for fire and forget missile systems. The tracker locks on to target images within an acquisition window using multiple image tracking algorithms to provide guidance commands to missile control systems. This basic tracker technology is used with the addition of a ranging algorithm based on sizing a cooperative target to perform autonomous guidance and control of a platform for an Advanced Development Project on automation and robotics. A ranging tracker is required to provide the positioning necessary for robotic control. A simple functional demonstration of the feasibility of this approach was performed and described. More realistic demonstrations are under way at NASA-JSC. In particular, this modified tracker, or robotic controller, will be used to autonomously guide the Man Maneuvering Unit (MMU) to targets such as disabled astronauts or tools as part of the EVA Retriever efforts. It will also be used to control the orbiter's Remote Manipulator Systems (RMS) in autonomous approach and positioning demonstrations. These efforts will also be discussed.

Incomplete Multisource Transfer Learning.

PubMed

Ding, Zhengming; Shao, Ming; Fu, Yun

2018-02-01

Transfer learning is generally exploited to adapt well-established source knowledge for learning tasks in weakly labeled or unlabeled target domain. Nowadays, it is common to see multiple sources available for knowledge transfer, each of which, however, may not include complete classes information of the target domain. Naively merging multiple sources together would lead to inferior results due to the large divergence among multiple sources. In this paper, we attempt to utilize incomplete multiple sources for effective knowledge transfer to facilitate the learning task in target domain. To this end, we propose an incomplete multisource transfer learning through two directional knowledge transfer, i.e., cross-domain transfer from each source to target, and cross-source transfer. In particular, in cross-domain direction, we deploy latent low-rank transfer learning guided by iterative structure learning to transfer knowledge from each single source to target domain. This practice reinforces to compensate for any missing data in each source by the complete target data. While in cross-source direction, unsupervised manifold regularizer and effective multisource alignment are explored to jointly compensate for missing data from one portion of source to another. In this way, both marginal and conditional distribution discrepancy in two directions would be mitigated. Experimental results on standard cross-domain benchmarks and synthetic data sets demonstrate the effectiveness of our proposed model in knowledge transfer from incomplete multiple sources.

ChemTrove: enabling a generic ELN to support chemistry through the use of transferable plug-ins and online data sources.

PubMed

Day, Aileen E; Coles, Simon J; Bird, Colin L; Frey, Jeremy G; Whitby, Richard J; Tkachenko, Valery E; Williams, Antony J

2015-03-23

In designing an Electronic Lab Notebook (ELN), there is a balance to be struck between keeping it as general and multidisciplinary as possible for simplicity of use and maintenance and introducing more domain-specific functionality to increase its appeal to target research areas. Here, we describe the results of a collaboration between the Royal Society of Chemistry (RSC) and the University of Southampton, guided by the aims of the Dial-a-Molecule Grand Challenge, intended to achieve the best of both worlds and augment a discipline-agnostic ELN, LabTrove, with chemistry-specific functionality and using data provided by the ChemSpider platform. This has been done using plug-in technology to ensure maximum transferability with minimal effort of the chemistry functionality to other ELNs and equally other subject-specific functionality to LabTrove. The resulting product, ChemTrove, has undergone a usability trial by selected academics, and the resulting feedback will guide the future development of the underlying ELN technology.

Project for the analysis of technology transfer

NASA Technical Reports Server (NTRS)

Kottenstette, J. P.; Freeman, J. E.; Staskin, E. R.

1971-01-01

The special task of preparing technology transfer profiles during the first six months of 1971 produced two major results: refining a new method for identifying and describing technology transfer activities, and generating practical insights into a number of issues associated with transfer programs.

HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications.

PubMed

Degorce, François; Card, Amy; Soh, Sharon; Trinquet, Eric; Knapik, Glenn P; Xie, Bing

2009-05-28

HTRF (Homogeneous Time Resolved Fluorescence) is the most frequently used generic assay technology to measure analytes in a homogenous format, which is the ideal platform used for drug target studies in high-throughput screening (HTS). This technology combines fluorescence resonance energy transfer technology (FRET) with time-resolved measurement (TR). In TR-FRET assays, a signal is generated through fluorescent resonance energy transfer between a donor and an acceptor molecule when in close proximity to each other. Buffer and media interference is dramatically reduced by dual-wavelength detection, and the final signal is proportional to the extent of product formation. The HTRF assay is usually sensitive and robust that can be miniaturized into the 384 and 1536-well plate formats. This assay technology has been applied to many antibody-based assays including GPCR signaling (cAMP and IP-One), kinases, cytokines and biomarkers, bioprocess (antibody and protein production), as well as the assays for protein-protein, proteinpeptide, and protein-DNA/RNA interactions.Since its introduction to the drug-screening world over ten years ago, researchers have used HTRF to expedite the study of GPCRs, kinases, new biomarkers, protein-protein interactions, and other targets of interest. HTRF has also been utilized as an alternative method for bioprocess monitoring. The first-generation HTRF technology, which uses Europium cryptate as a fluorescence donor to monitor reactions between biomolecules, was extended in 2008 through the introduction of a second-generation donor, Terbium cryptate (Tb), enhancing screening performance. Terbium cryptate possesses different photophysical properties compared to Europium, including increased quantum yield and a higher molar extinction coefficient. In addition to being compatible with the same acceptor fluorophors used with Europium, it can serve as a donor fluorophore to green-emitting fluors because it has multiple emission peaks including one at 490 nm. Moreover, all Terbium HTRF assays can be read on the same HTRF-compatible instruments as Europium HTRF assays.Overall, HTRF is a highly sensitive, robust technology for the detection of molecular interactions in vitro and is widely used for primary and secondary screening phases of drug development. This review addresses the general principles of HTRF and its current applications in drug discovery.

Technology transfer within the government

NASA Technical Reports Server (NTRS)

Russell, John

1992-01-01

The report of a workshop panel concerned with technology transfer within the government is presented. The presentation is made in vugraph form. The assigned subtopic for this panel are as follows: (1) transfer from non-NASA US government technology developers to NASA space missions/programs; and (2) transfer from NASA to other US government space mission programs. A specific area of inquiry was Technology Maturation Milestones. Three areas were investigated: technology development; advanced development; and flight hardware development.

The human element in technology transfer

NASA Technical Reports Server (NTRS)

Peake, H. J.

1978-01-01

A transfer model composed of three roles and their linkages was considered. This model and a growing body of experience was analyzed to provide guidance in the human elements of technology transfer. For example, criteria for selection of technology transfer agents was described, and some needed working climate factors were known. These concepts were successfully applied to transfer activities.

Technology transfer: the key to fusion commercialization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burnett, S.C.

1981-01-01

The paper brings to light some of the reasons why technology transfer is difficult in fusion, examines some of the impediments to the process, and finally looks at a successful example of technology transfer. The paper considers some subjective features of fusion - one might call them the sociology of fusion - that are none the less real and that serve as impediments to technology transfer.

Dual-Use Space Technology Transfer Conference and Exhibition. Volume 2

NASA Technical Reports Server (NTRS)

Krishen, Kumar (Compiler)

1994-01-01

This is the second volume of papers presented at the Dual-Use Space Technology Transfer Conference and Exhibition held at the Johnson Space Center February 1-3, 1994. Possible technology transfers covered during the conference were in the areas of information access; innovative microwave and optical applications; materials and structures; marketing and barriers; intelligent systems; human factors and habitation; communications and data systems; business process and technology transfer; software engineering; biotechnology and advanced bioinstrumentation; communications signal processing and analysis; medical care; applications derived from control center data systems; human performance evaluation; technology transfer methods; mathematics, modeling, and simulation; propulsion; software analysis and decision tools; systems/processes in human support technology; networks, control centers, and distributed systems; power; rapid development; perception and vision technologies; integrated vehicle health management; automation technologies; advanced avionics; and robotics technologies.

National Technology Transfer Center

NASA Technical Reports Server (NTRS)

Rivers, Lee W.

1992-01-01

Viewgraphs on the National Technology Transfer Center (NTTC) are provided. The NTTC mission is to serve as a hub for the nationwide technology-transfer network to expedite the movement of federally developed technology into the stream of commerce. A description of the Center is provided.

Technology transfer to a developing nation, Korea

NASA Technical Reports Server (NTRS)

Stone, C. A.; Uccetta, S. J.

1973-01-01

An experimental project is reported which was undertaken. to determine if selected types of technology developed for the aerospace program during the past decade are relevant to specific industrial problems of a developing nation and to test whether a structured program could facilitate the transfer of relevant technologies. The Korea Institute of Science and Technology and the IIT Research Institute were selected as the active transfer agents to participate in the program. The pilot project was based upon the approach to the transfer of domestic technology developed by the NASA Technology Utilization Division and utilized the extensive data and technical resources available through the Space Agency and its contractors. This pilot project has helped to clarify some aspects of the international technology transfer process and to upgrade Korean technological capabilities.

EPA Reports to Congress on Technology Transfer

EPA Pesticide Factsheets

Agencies are required to report to the Congress annually on their technology transfer activities. These reports summarize technology transfer activities of the EPA’s federal laboratories, by fiscal year.

A hypertext-based Internet-assessable database for the MSFC Technology Transfer Office

NASA Technical Reports Server (NTRS)

Jackson, Jeff

1994-01-01

There exists a continuing need to disseminate technical information and facilities capabilities from NASA field centers in an effort to promote the successful transfer of technologies developed with public funds to the private sector. As technology transfer is a stated NASA mission, there exists a critical need for NASA centers to document technology capabilities and disseminate this information on as wide a basis as possible. Certainly local and regional dissemination is critical, but global dissemination of scientific and engineering facilities and capabilities gives NASA centers the ability to contribute to technology transfer on a much broader scale. Additionally, information should be disseminated in a complete and rapidly available form. To accomplish this information dissemination, the unique capabilities of the Internet are being exploited. The Internet allows widescale information distribution in a rapid fashion to aid in the accomplishment of technology transfer goals established by the NASA/MSFC Technology Transfer Office. Rapid information retrieval coupled with appropriate electronic feedback, allows the scientific and technical capabilities of Marshall Space Flight Center, often unique in the world, to be explored by a large number of potential benefactors of NASA (or NASA-derived) technologies. Electronic feedback, coupled with personal contact with the MSFC Technology Transfer Office personnel, allows rapid responses to technical requests from industry and academic personnel as well as private citizens. The remainder of this report gives a brief overview of the Mosaic software and a discussion of technology transfer office and laboratory facilities data that have been made available on the Internet to promote technology transfer.

Video performance for high security applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Connell, Jack C.; Norman, Bradley C.

2010-06-01

The complexity of physical protection systems has increased to address modern threats to national security and emerging commercial technologies. A key element of modern physical protection systems is the data presented to the human operator used for rapid determination of the cause of an alarm, whether false (e.g., caused by an animal, debris, etc.) or real (e.g., a human adversary). Alarm assessment, the human validation of a sensor alarm, primarily relies on imaging technologies and video systems. Developing measures of effectiveness (MOE) that drive the design or evaluation of a video system or technology becomes a challenge, given the subjectivitymore » of the application (e.g., alarm assessment). Sandia National Laboratories has conducted empirical analysis using field test data and mathematical models such as binomial distribution and Johnson target transfer functions to develop MOEs for video system technologies. Depending on the technology, the task of the security operator and the distance to the target, the Probability of Assessment (PAs) can be determined as a function of a variety of conditions or assumptions. PAs used as an MOE allows the systems engineer to conduct trade studies, make informed design decisions, or evaluate new higher-risk technologies. This paper outlines general video system design trade-offs, discusses ways video can be used to increase system performance and lists MOEs for video systems used in subjective applications such as alarm assessment.« less

Study of Federal technology transfer activities in areas of interest to NASA Office of Space and Terrestrial Applications

NASA Technical Reports Server (NTRS)

Madigan, J. A.; Earhart, R. W.

1978-01-01

Forty-three ongoing technology transfer programs in Federal agencies other than NASA were selected from over 200 current Federal technology transfer activities. Selection was made and specific technology transfer mechanisms utilized. Detailed information was obtained on the selected programs by reviewing published literature, and conducting telephone interviews with each program manager. Specific information collected on each program includes technology areas; user groups, mechanisms employed, duration of program, and level of effort. Twenty-four distinct mechanisms are currently employed in Federal technology transfer activities totaling $260 million per year. Typical applications of each mechanism were reviewed, and caveats on evaluating program effectiveness were discussed. A review of recent federally funded research in technology transfer to state and local governments was made utilizing the Smithsonian Science Information Exchange, and abstracts of interest to NASA were selected for further reference.

Fuel Reforming Technologies (BRIEFING SLIDES)

DTIC Science & Technology

2009-09-01

Heat and Mass Transfer , Catalysis...Gallons Of Fuel/Day/1100men Deployment  To Reduce Noise/Thermal Signature And 4 Environmental Emissions Advanced Heat and Mass Transfer 5 Advanced... Heat and Mass & Transfer Technologies Objective Identify And Develop New Technologies To Enhance Heat And Mass Transfer In Deployed Energy

TARGETED TECHNOLOGY TRANSFER TO US INDEPENDENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donald F. Duttlinger; E. Lance Cole

2005-01-01

The Petroleum Technology Transfer Council (PTTC) continued pursuing its mission of assisting U.S. independent oil and gas producers with timely, informed technology decisions during Fiscal Year 2004 (FY04). PTTC has active grassroots programs through its 10 Regional Lead Organizations (RLOs) and 2 satellite offices. They bring research and academia to the table via their association with geological surveys and engineering departments. The regional directors interact with independent oil and gas producers through technology workshops, resource centers, websites, newsletters, technical publications and other cooperative outreach efforts. PTTC's Headquarters (HQ) staff receives direction from a National Board of Directors predominantly comprised ofmore » American natural gas and oil producers to plan and manage the overall technology transfer program. PTTC HQ implements a comprehensive communications program by interconnecting the talents of the National Board, 10 Regional Producer Advisory Groups (PAG) and the RLOs with industry across the U.S. PTTC effectively combines federal funding through the Department of Energy's (DOE) Office of Fossil Energy, namely the Strategic Center for Natural Gas and Oil with state and industry contributions to share application of upstream technologies. Ultimately, these efforts factor in to provide a safe, secure and reliable energy supply for American consumers. This integrated resource base, combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff, are achieving notable results regarding domestic production figures. PTTC is increasingly recognized as a critical resource for information and access to technologies by providing direct contact with research, development and demonstration (RD&D) results. A key to the program is demonstrating proven technologies that can be applied broadly and rapidly. This technical progress report summarizes PTTC's accomplishments during FY04. Activities remained at high levels. Board and staff interaction has defined strategic thrusts to further outreach. Networking, involvement in technical activities and an active exhibit schedule are increasing PTTC's sphere of influence with both producers and the service sector. PTTC's reputation for unbiased bottom line information stimulates cooperative ventures with other organizations. Efforts to build the contact database and a growing E-mail Technology Alert service are expanding PTTC's audience.« less

Transferability of economic evaluations of medical technologies: a new technology for orthopedic surgery.

PubMed

Steuten, Lotte; Vallejo-Torres, Laura; Young, Terry; Buxton, Martin

2008-05-01

Transferring results of economic evaluations across countries or jurisdictions can potentially save scarce evaluation resources while helping to make market access and reimbursement decisions in a timely fashion. This article points out why transferring results of economic evaluations is particularly important in the field of medical technologies. It then provides an overview of factors that are previously identified in the literature as affecting transferability of economic evaluations, as well as methods for transferring results in a scientifically sound way. As the current literature almost exclusively relates to transferability of pharmacoeconomic evaluations, this article highlights those factors and methodologies that are of particular relevance to transferring medical technology assessments. Considering the state-of-the-art literature and a worked, real life, example of transferring an economic evaluation of a product used in orthopedic surgery, we provide recommendations for future work in this important area of medical technology assessment.

AAC technology transfer: an AAC-RERC report.

PubMed

Higginbotham, D Jeffery; Beukelman, David; Blackstone, Sarah; Bryen, Diane; Caves, Kevin; Deruyter, Frank; Jakobs, Thomas; Light, Janice; McNaughton, David; Moulton, Bryan; Shane, Howard; Williams, Michael B

2009-03-01

Transferring innovative technologies from the university to the manufacturing sector can often be an elusive and problematic process. The Rehabilitation and Engineering Research Center on Communication Enhancement (AAC-RERC) has worked with the manufacturing community for the last 10 years. The purpose of this article is to discuss barriers to technology transfer, to outline some technology transfer strategies, and to illustrate these strategies with AAC-RERC related activities.

Technology transfer methodology

NASA Technical Reports Server (NTRS)

Labotz, Rich

1991-01-01

Information on technology transfer methodology is given in viewgraph form. Topics covered include problems in economics, technology drivers, inhibitors to using improved technology in development, technology application opportunities, and co-sponsorship of technology.

Information to Change the World--Fulfilling the Information Needs of Technology Transfer.

ERIC Educational Resources Information Center

Duberman, Josh; Zeller, Martin

1996-01-01

Provides an introduction to fulfilling the information needs of technology transfer. Highlights include a definition of technology transfer; government and university involvement; industry's role; publishers; an annotated list of information sources and contacts; technology assessment, including patent searching, competitive intelligence, and…

Search Technologies | NCI Technology Transfer Center | TTC

Cancer.gov

Our team of technology transfer specialists has specialized training in invention reporting, patenting, patent strategy, executing technology transfer agreements and marketing. TTC is comprised of professionals with diverse legal, scientific, and business/marketing expertise. Most of our staff hold doctorate-level technical and/or legal training.

Available Technologies | NCI Technology Transfer Center | TTC

Cancer.gov

Our team of technology transfer specialists has specialized training in invention reporting, patenting, patent strategy, executing technology transfer agreements and marketing. TTC is comprised of professionals with diverse legal, scientific, and business/marketing expertise. Most of our staff hold doctorate-level technical and/or legal training.

Australian University Technology Transfer Managers: Backgrounds, Work Roles, Specialist Skills and Perceptions

ERIC Educational Resources Information Center

Harman, Grant; Stone, Christopher

2006-01-01

Technology transfer managers are a new group of specialist professionals engaged in facilitating transfer of university research discoveries and inventions to business firms and other research users. With relatively high academic qualifications and enjoying higher salaries than many other comparable university staff, technology transfer managers…

Dual-Use Space Technology Transfer Conference and Exhibition. Volume 1

NASA Technical Reports Server (NTRS)

Krishen, Kumar (Compiler)

1994-01-01

This document contains papers presented at the Dual-Use Space Technology Transfer Conference and Exhibition held at the Johnson Space Center February 1-3, 1994. Possible technology transfers covered during the conference were in the areas of information access; innovative microwave and optical applications; materials and structures; marketing and barriers; intelligent systems; human factors and habitation; communications and data systems; business process and technology transfer; software engineering; biotechnology and advanced bioinstrumentation; communications signal processing and analysis; new ways of doing business; medical care; applications derived from control center data systems; human performance evaluation; technology transfer methods; mathematics, modeling, and simulation; propulsion; software analysis and decision tools systems/processes in human support technology; networks, control centers, and distributed systems; power; rapid development perception and vision technologies; integrated vehicle health management; automation technologies; advanced avionics; ans robotics technologies. More than 77 papers, 20 presentations, and 20 exhibits covering various disciplines were presented b experts from NASA, universities, and industry.

Applications of aerospace technology in industry: A technology transfer profile, nondestructive testing

NASA Technical Reports Server (NTRS)

1972-01-01

The development of nondestructive testing procedures by NASA and the transfer of nondestructive testing to technology to civilian industry are discussed. The subjects presented are: (1) an overview of the nondestructive testing field, (2) NASA contributions to the field of nondestructive testing, (3) dissemination of NASA contributions, and (4) a transfer profile. Attachments are included which provide a brief description of common nondestructive testing methods and summarize the technology transfer reports involving NASA generated nondestructive testing technology.

Program for transfer research and impact studies

NASA Technical Reports Server (NTRS)

Rusnak, J. J.; Freeman, J. E.; Hartley, J. M.; Kottenstette, J. P.; Staskin, E. R.

1973-01-01

Research activities conducted under the Program for Transfer Research and Impact Studies (TRIS) during 1972 included: (1) preparation of 10,196 TSP requests for TRIS application analysis; (2) interviews with over 500 individuals concerning the technical, economic, and social impacts of NASA-generated technology; (3) preparation of 38 new technology transfer example files and 101 new transfer cases; and (4) maintenance of a technology transfer library containing more than 2,900 titles. Six different modes of technology utilization are used to illustrate the pervasiveness of the transfer and diffusion of aerospace innovations. These modes also provide a basis for distinguishing the unique characteristics of the NASA Technology Utilization Program. An examination is reported of the ways in which NASA-generated technology is contributing to beneficial social change in five major areas of human concern: health, environment, safety, transportation, and communication.

NASA Technology Transfer System

NASA Technical Reports Server (NTRS)

Tran, Peter B.; Okimura, Takeshi

2017-01-01

NTTS is the IT infrastructure for the Agency's Technology Transfer (T2) program containing 60,000+ technology portfolio supporting all ten NASA field centers and HQ. It is the enterprise IT system for facilitating the Agency's technology transfer process, which includes reporting of new technologies (e.g., technology invention disclosures NF1679), protecting intellectual properties (e.g., patents), and commercializing technologies through various technology licenses, software releases, spinoffs, and success stories using custom built workflow, reporting, data consolidation, integration, and search engines.

Technology transfer of remote sensing technology

NASA Technical Reports Server (NTRS)

Smith, A. D.

1980-01-01

The basic philosophy and some current activities of MSFC Technology Transfer with regard to remote sensing technology are briefly reviewed. Among the problems that may be alleviated through such technology transfer are the scarcity of energy and mineral resources, the alteration of the environment by man, unpredictable natural disasters, and the effect of unanticipated climatic change on agricultural productivity.

NASA programs in technology transfer and their relation to remote sensing education

NASA Technical Reports Server (NTRS)

Weinstein, R. H.

1980-01-01

Technology transfer to users is a central feature of NASA programs. In each major area of responsibility, a variety of mechanisms was established to provide for this transfer of operational capability to the proper end user, be it a Federal agency, industry, or other public sector users. In addition, the Technology Utilization program was established to cut across all program areas and to make available a wealth of 'spinoff' technology (i.e., secondary applications of space technology to ground-based use). The transfer of remote sensing technology, particularly to state and local users, presents some real challenges in application and education for NASA and the university community. The agency's approach to the transfer of remote sensing technology and the current and potential role of universities in the process are considered.

Technology transfer metrics: Measurement and verification of data/reusable launch vehicle business analysis

NASA Technical Reports Server (NTRS)

Trivoli, George W.

1996-01-01

Congress and the Executive Branch have mandated that all branches of the Federal Government exert a concentrated effort to transfer appropriate government and government contractor-developed technology to the industrial use in the U.S. economy. For many years, NASA has had a formal technology transfer program to transmit information about new technologies developed for space applications into the industrial or commercial sector. Marshall Space Flight Center (MSFC) has been in the forefront of the development of U.S. industrial assistance programs using technologies developed at the Center. During 1992-93, MSFC initiated a technology transfer metrics study. The MSFC study was the first of its kind among the various NASA centers. The metrics study is a continuing process, with periodic updates that reflect on-going technology transfer activities.

77 FR 46909 - Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... Technology Transfer (STTR) Program Policy Directives AGENCY: U.S. Small Business Administration. ACTION...) and Small Business Technology Transfer Program (STTR) Policy Directives. These amendments implement... to Edsel Brown, Assistant Director, Office of Technology, U.S. Small Business Administrator, 409...

Development and Technology Transfer of the Syncro Blue Tube (Gabriel) Magnetically Guided Feeding Tube

DTIC Science & Technology

2017-06-01

other documentation. TITLE: Development and Technology Transfer of the Syncro Blue Tube (Gabriel) Magnetically Guided Feeding Tube REPORT DOCUMENTATION...TITLE AND SUBTITLE Development and Technology Transfer of the Syncro Blue Tube (Gabriel) Magnetically Guided Feeding Tube 5a. CONTRACT NUMBER W81XWH-09-2...Technical Abstract: Further Development and Technology Transfer of the Syncro BLUETUBE™ (Gabriel) Magnetically Guided Feeding Tube. New Primary

Chaining direct memory access data transfer operations for compute nodes in a parallel computer

DOEpatents

Archer, Charles J.; Blocksome, Michael A.

2010-09-28

Methods, systems, and products are disclosed for chaining DMA data transfer operations for compute nodes in a parallel computer that include: receiving, by an origin DMA engine on an origin node in an origin injection FIFO buffer for the origin DMA engine, a RGET data descriptor specifying a DMA transfer operation data descriptor on the origin node and a second RGET data descriptor on the origin node, the second RGET data descriptor specifying a target RGET data descriptor on the target node, the target RGET data descriptor specifying an additional DMA transfer operation data descriptor on the origin node; creating, by the origin DMA engine, an RGET packet in dependence upon the RGET data descriptor, the RGET packet containing the DMA transfer operation data descriptor and the second RGET data descriptor; and transferring, by the origin DMA engine to a target DMA engine on the target node, the RGET packet.

Low latency, high bandwidth data communications between compute nodes in a parallel computer

DOEpatents

Blocksome, Michael A

2014-04-01

Methods, systems, and products are disclosed for data transfers between nodes in a parallel computer that include: receiving, by an origin DMA on an origin node, a buffer identifier for a buffer containing data for transfer to a target node; sending, by the origin DMA to the target node, a RTS message; transferring, by the origin DMA, a data portion to the target node using a memory FIFO operation that specifies one end of the buffer from which to begin transferring the data; receiving, by the origin DMA, an acknowledgement of the RTS message from the target node; and transferring, by the origin DMA in response to receiving the acknowledgement, any remaining data portion to the target node using a direct put operation that specifies the other end of the buffer from which to begin transferring the data, including initiating the direct put operation without invoking an origin processing core.

Low latency, high bandwidth data communications between compute nodes in a parallel computer

DOEpatents

Blocksome, Michael A

2014-04-22

Methods, systems, and products are disclosed for data transfers between nodes in a parallel computer that include: receiving, by an origin DMA on an origin node, a buffer identifier for a buffer containing data for transfer to a target node; sending, by the origin DMA to the target node, a RTS message; transferring, by the origin DMA, a data portion to the target node using a memory FIFO operation that specifies one end of the buffer from which to begin transferring the data; receiving, by the origin DMA, an acknowledgement of the RTS message from the target node; and transferring, by the origin DMA in response to receiving the acknowledgement, any remaining data portion to the target node using a direct put operation that specifies the other end of the buffer from which to begin transferring the data, including initiating the direct put operation without invoking an origin processing core.

Low latency, high bandwidth data communications between compute nodes in a parallel computer

DOEpatents

Blocksome, Michael A

2013-07-02

Methods, systems, and products are disclosed for data transfers between nodes in a parallel computer that include: receiving, by an origin DMA on an origin node, a buffer identifier for a buffer containing data for transfer to a target node; sending, by the origin DMA to the target node, a RTS message; transferring, by the origin DMA, a data portion to the target node using a memory FIFO operation that specifies one end of the buffer from which to begin transferring the data; receiving, by the origin DMA, an acknowledgement of the RTS message from the target node; and transferring, by the origin DMA in response to receiving the acknowledgement, any remaining data portion to the target node using a direct put operation that specifies the other end of the buffer from which to begin transferring the data, including initiating the direct put operation without invoking an origin processing core.

Fluidized-Bed Heat Transfer Modeling for the Development of Particle/Supercritical-CO2 Heat Exchanger

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Zhiwen; Martinek, Janna G

Concentrating solar power (CSP) technology is moving toward high-temperature and high-performance design. One technology approach is to explore high-temperature heat-transfer fluids and storage, integrated with a high-efficiency power cycle such as the supercritical carbon dioxide (s-CO2) Brayton power cycle. The s-CO2 Brayton power system has great potential to enable the future CSP system to achieve high solar-to-electricity conversion efficiency and to reduce the cost of power generation. Solid particles have been proposed as a possible high-temperature heat-transfer medium that is inexpensive and stable at high temperatures above 1,000 degrees C. The particle/heat exchanger provides a connection between the particles andmore » s-CO2 fluid in the emerging s-CO2 power cycles in order to meet CSP power-cycle performance targets of 50% thermal-to-electric efficiency, and dry cooling at an ambient temperature of 40 degrees C. The development goals for a particle/s-CO2 heat exchanger are to heat s-CO2 to =720 degrees C and to use direct thermal storage with low-cost, stable solid particles. This paper presents heat-transfer modeling to inform the particle/s-CO2 heat-exchanger design and assess design tradeoffs. The heat-transfer process was modeled based on a particle/s-CO2 counterflow configuration. Empirical heat-transfer correlations for the fluidized bed and s-CO2 were used in calculating the heat-transfer area and optimizing the tube layout. A 2-D computational fluid-dynamics simulation was applied for particle distribution and fluidization characterization. The operating conditions were studied from the heat-transfer analysis, and cost was estimated from the sizing of the heat exchanger. The paper shows the path in achieving the cost and performance objectives for a heat-exchanger design.« less

University Technology Transfer Information Processing from the Attention Based View

ERIC Educational Resources Information Center

Hamilton, Clovia

2015-01-01

Between 2005 and 2011, there was no substantial growth in licenses executed by university technology transfer offices. Since the passage of the Bayh Dole Act of 1980, universities have owned technological inventions afforded by federal research funding. There are still university technology transfer offices that struggle with increasing their…

Effetive methods in educating extension agents and farmers on conservation farming technology

USDA-ARS?s Scientific Manuscript database

Adoption of new technologies requires transfer of information from developers to end users. Efficiency of the transfer process influences the rate of adoption and ultimate impact of the technology. Various channels are used to transfer technology from researchers to farmers. Two commonly used ones ...

Technology Transfer through Training: Emerging Roles for the University.

ERIC Educational Resources Information Center

Bergsma, Harold M.

The importance of training in the technology transfer process is discussed, with special consideration to conditions in developing countries. Also considered is the role universities can play in training to promote technology transfer. Advisors on training and curriculum development are needed to introduce a new technology. Training farmers to…

KSC-2013-3575

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Lewis Parrish, senior Technology Transfer specialist for Qinetiq at NASA's Kennedy Space Center in Florida, discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

What Is Technology Transfer? | Poster

Cancer.gov

The NCI Technology Transfer Center (TTC) facilitates partnerships between NIH research laboratories and external partners. With a team of technology transfer specialists, NCI TTC guides interactions from discovery to patenting, as well as from collaboration and invention development to licensing.

Technology Transfer: A Think Tank Approach to Managing Innovation in the Public Sector

DTIC Science & Technology

1985-01-01

TECHNOLOGY TRANSFER: A THINK TANK APPROACH TO MANAGING INNOVATION IN THE PUBLIC SECTOR CISIRIBUTIOtl STATEMENT A Approved for Public Release...NAVAL FACILITIES ENGINEERING COMMAND TECHNOLOGY TRANSFER: A THINK TANK APPROACH TO MANAGING INNOVATION IN THE PUBLIC SECTOR Edited by J. W. Creighton...Publication of this book, Technology Transfer: A Think Tank Approach to Managing Innovation in the Public Sector, was in part supported by funds from the U.S

Auto-disable syringes for immunization: issues in technology transfer.

PubMed Central

Lloyd, J. S.; Milstien, J. B.

1999-01-01

WHO and its partners recommend the use of auto-disable syringes, "bundled" with the supply of vaccines when donor dollars are used, in all mass immunization campaigns, and also strongly advocate their use in routine immunization programmes. Because of the relatively high price of auto-disable syringes, WHO's Technical Network for Logistics in Health recommends that activities be initiated to encourage the transfer of production technology for these syringes as a means of promoting their use and enhancing access to the technology. The present article examines factors influencing technology transfer, including feasibility, corporate interest, cost, quality assurance, intellectual property considerations, and probable time frames for implementation. Technology transfer activities are likely to be complex and difficult, and may not result in lower prices for syringes. Guidelines are offered on technology transfer initiatives for auto-disable syringes to ensure the quality of the product, the reliability of the supply, and the feasibility of the technology transfer activity itself. PMID:10680248

Transfer of motor learning engages specific neural substrates during motor memory consolidation dependent on the practice structure.

PubMed

Kantak, Shailesh S; Sullivan, Katherine J; Fisher, Beth E; Knowlton, Barbara J; Winstein, Carolee J

2011-01-01

The authors investigated how brain activity during motor-memory consolidation contributes to transfer of learning to novel versions of a motor skill following distinct practice structures. They used 1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) immediately after constant or variable practice of an arm movement skill to interfere with primary motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC). The effect of interference was assessed through skill performance on two transfer targets: one within and one outside the range of practiced movement parameters for the variable practice group. For the control (no rTMS) group, variable practice benefited delayed transfer performance more than constant practice. The rTMS effect on delayed transfer performance differed for the two transfer targets. For the within-range target, rTMS interference had no significant affect on the delayed transfer after either practice structure. However, for the outside-range target, rTMS interference to DLPFC but not M1 attenuated delayed transfer benefit following variable practice. Additionally, for the outside-range target, rTMS interference to M1 but not DLPFC attenuated delayed transfer following constant practice. This suggests that variable practice may promote reliance on DLPFC for memory consolidation associated with outside-range transfer of learning, whereas constant practice may promote reliance on M1 for consolidation and long-term transfer.

Evaluating disparities in the U.S. technology transfer ecosystem to improve bench to business translation.

PubMed

Weis, James; Bashyam, Ashvin; Ekchian, Gregory J; Paisner, Kathryn; Vanderford, Nathan L

2018-01-01

Background: A large number of highly impactful technologies originated from academic research, and the transfer of inventions from academic institutions to private industry is a major driver of economic growth, and a catalyst for further discovery. However, there are significant inefficiencies in academic technology transfer. In this work, we conducted a data-driven assessment of translational activity across United States (U.S.) institutions to better understand how effective universities are in facilitating the transfer of new technologies into the marketplace. From this analysis, we provide recommendations to guide technology transfer policy making at both the university and national level. Methods: Using data from the Association of University Technology Managers U.S. Licensing Activity Survey, we defined a commercialization pipeline that reflects the typical path intellectual property takes; from initial research funding to startup formation and gross income. We use this pipeline to quantify the performance of academic institutions at each step of the process, as well as overall, and identify the top performing institutions via mean reciprocal rank. The corresponding distributions were visualized and disparities quantified using the Gini coefficient. Results: We found significant discrepancies in commercialization activity between institutions; a small number of institutions contribute to the vast majority of total commercialization activity. By examining select top performing institutions, we suggest improvements universities and technology transfer offices could implement to emulate the environment at these high-performing institutions. Conclusion: Significant disparities in technology transfer performance exist in which a select set of institutions produce a majority share of the total technology transfer activity. This disparity points to missed commercialization opportunities, and thus, further investigation into the distribution of technology transfer effectiveness across institutions and studies of policy changes that would improve the effectiveness of the commercialization pipeline is warranted.

Evaluating disparities in the U.S. technology transfer ecosystem to improve bench to business translation

PubMed Central

Paisner, Kathryn; Vanderford, Nathan L.

2018-01-01

Background: A large number of highly impactful technologies originated from academic research, and the transfer of inventions from academic institutions to private industry is a major driver of economic growth, and a catalyst for further discovery. However, there are significant inefficiencies in academic technology transfer. In this work, we conducted a data-driven assessment of translational activity across United States (U.S.) institutions to better understand how effective universities are in facilitating the transfer of new technologies into the marketplace. From this analysis, we provide recommendations to guide technology transfer policy making at both the university and national level. Methods: Using data from the Association of University Technology Managers U.S. Licensing Activity Survey, we defined a commercialization pipeline that reflects the typical path intellectual property takes; from initial research funding to startup formation and gross income. We use this pipeline to quantify the performance of academic institutions at each step of the process, as well as overall, and identify the top performing institutions via mean reciprocal rank. The corresponding distributions were visualized and disparities quantified using the Gini coefficient. Results: We found significant discrepancies in commercialization activity between institutions; a small number of institutions contribute to the vast majority of total commercialization activity. By examining select top performing institutions, we suggest improvements universities and technology transfer offices could implement to emulate the environment at these high-performing institutions. Conclusion: Significant disparities in technology transfer performance exist in which a select set of institutions produce a majority share of the total technology transfer activity. This disparity points to missed commercialization opportunities, and thus, further investigation into the distribution of technology transfer effectiveness across institutions and studies of policy changes that would improve the effectiveness of the commercialization pipeline is warranted. PMID:29721313

48 CFR 970.5227-11 - Patent rights-management and operating contracts, for-profit contractor, non-technology transfer.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and operating contracts, for-profit contractor, non-technology transfer. 970.5227-11 Section 970.5227...-technology transfer. Insert the following clause in solicitations and contracts in accordance with 970.2703-1(b)(4): Patent Rights—Management and Operating Contracts, for-Profit Contractor, Non-Technology...

48 CFR 970.5227-2 - Rights in data-technology transfer.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Rights in data-technology... for Management and Operating Contracts 970.5227-2 Rights in data-technology transfer. As prescribed in 48 CFR 970.2704-3(b), insert the following clause: Rights in Data—Technology Transfer (DEC 2000) (a...

Key Findings and Recommendations for Technology Transfer at the ITS JPO

DOT National Transportation Integrated Search

2011-03-18

This report provides key findings and recommendations for technology transfer at the Intelligent Transportation Systems Joint Program Office (ITS JPO) based upon an assessment of best practices in technology transfer in other industries, such as nati...

On transferring the grid technology to the biomedical community.

PubMed

Mohammed, Yassene; Sax, Ulrich; Dickmann, Frank; Lippert, Joerg; Solodenko, Juri; von Voigt, Gabriele; Smith, Matthew; Rienhoff, Otto

2010-01-01

Natural scientists such as physicists pioneered the sharing of computing resources, which resulted in the Grid. The inter domain transfer process of this technology has been an intuitive process. Some difficulties facing the life science community can be understood using the Bozeman's "Effectiveness Model of Technology Transfer". Bozeman's and classical technology transfer approaches deal with technologies that have achieved certain stability. Grid and Cloud solutions are technologies that are still in flux. We illustrate how Grid computing creates new difficulties for the technology transfer process that are not considered in Bozeman's model. We show why the success of health Grids should be measured by the qualified scientific human capital and opportunities created, and not primarily by the market impact. With two examples we show how the Grid technology transfer theory corresponds to the reality. We conclude with recommendations that can help improve the adoption of Grid solutions into the biomedical community. These results give a more concise explanation of the difficulties most life science IT projects are facing in the late funding periods, and show some leveraging steps which can help to overcome the "vale of tears".

Signaling completion of a message transfer from an origin compute node to a target compute node

DOEpatents

Blocksome, Michael A [Rochester, MN; Parker, Jeffrey J [Rochester, MN

2011-05-24

Signaling completion of a message transfer from an origin node to a target node includes: sending, by an origin DMA engine, an RTS message, the RTS message specifying an application message for transfer to the target node from the origin node; receiving, by the origin DMA engine, a remote get message containing a data descriptor for the message and a completion notification descriptor, the completion notification descriptor specifying a local direct put transfer operation for transferring data locally on the origin node; inserting, by the origin DMA engine in an injection FIFO buffer, the data descriptor followed by the completion notification descriptor; transferring, by the origin DMA engine to the target node, the message in dependence upon the data descriptor; and notifying, by the origin DMA engine, the application that transfer of the message is complete in dependence upon the completion notification descriptor.

Signaling completion of a message transfer from an origin compute node to a target compute node

DOEpatents

Blocksome, Michael A [Rochester, MN

2011-02-15

Signaling completion of a message transfer from an origin node to a target node includes: sending, by an origin DMA engine, an RTS message, the RTS message specifying an application message for transfer to the target node from the origin node; receiving, by the origin DMA engine, a remote get message containing a data descriptor for the message and a completion notification descriptor, the completion notification descriptor specifying a local memory FIFO data transfer operation for transferring data locally on the origin node; inserting, by the origin DMA engine in an injection FIFO buffer, the data descriptor followed by the completion notification descriptor; transferring, by the origin DMA engine to the target node, the message in dependence upon the data descriptor; and notifying, by the origin DMA engine, the application that transfer of the message is complete in dependence upon the completion notification descriptor.

Risk Management in Biologics Technology Transfer.

PubMed

Toso, Robert; Tsang, Jonathan; Xie, Jasmina; Hohwald, Stephen; Bain, David; Willison-Parry, Derek

Technology transfer of biological products is a complex process that is important for product commercialization. To achieve a successful technology transfer, the risks that arise from changes throughout the project must be managed. Iterative risk analysis and mitigation tools can be used to both evaluate and reduce risk. The technology transfer stage gate model is used as an example tool to help manage risks derived from both designed process change and unplanned changes that arise due to unforeseen circumstances. The strategy of risk assessment for a change can be tailored to the type of change. In addition, a cross-functional team and centralized documentation helps maximize risk management efficiency to achieve a successful technology transfer. © PDA, Inc. 2016.

Transfer research and impact studies program

NASA Technical Reports Server (NTRS)

Freeman, J. E. (Editor)

1975-01-01

Methods developed for stimulating interest in the transfer of NASA-originated technology are described. These include: new information packaging concepts; technology transfer via people transfer; information management systems; data bank operations; and professional communication activities.

Biomedical technology transfer applications of NASA science and technology

NASA Technical Reports Server (NTRS)

1972-01-01

The identification and solution of research and clinical problems in cardiovascular medicine which were investigated by means of biomedical data transfer are reported. The following are sample areas that were focused upon by the Stanford University Biomedical Technology Transfer Team: electrodes for hemiplegia research; vectorcardiogram computer analysis; respiration and phonation electrodes; radiotelemetry of intracranial pressure; and audiotransformation of the electrocardiographic signal. It is concluded that this biomedical technology transfer is significantly aiding present research in cardiovascular medicine.

Fully-Implicit Navier-Stokes (FIN-S)

NASA Technical Reports Server (NTRS)

Kirk, Benjamin S.

2010-01-01

FIN-S is a SUPG finite element code for flow problems under active development at NASA Lyndon B. Johnson Space Center and within PECOS: a) The code is built on top of the libMesh parallel, adaptive finite element library. b) The initial implementation of the code targeted supersonic/hypersonic laminar calorically perfect gas flows & conjugate heat transfer. c) Initial extension to thermochemical nonequilibrium about 9 months ago. d) The technologies in FIN-S have been enhanced through a strongly collaborative research effort with Sandia National Labs.

Quarterly Technical Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mary K. Banken

This project has identified all FDD oil reservoirs in Oklahoma; grouped those reservoirs into plays that have similar depositional origins; collected, organized, and analyzed all available data; conducted characterization and simulation studies on selected reservoirs in each plays; and implemented a technology transfer program targeted to the operators of FDD reservoirs. By fulfilling these objectives, the FDD project has had the goal of helping to sustain the life expectancy of existing wells and provide incentive for development and exploratory wells with the ultimate objective of increasing oil recovery.

Benefits briefing notebook: The secondary application of aerospace technology in other sectors of the economy

NASA Technical Reports Server (NTRS)

1976-01-01

Resource information on the transfer of aerospace technology to other sectors of the U.S. economy is presented. The contents of this notebook are divided into three sections: (1) benefit cases, (2) transfer overview, and (3) indexes. Transfer examples relevant to each subject area are presented. Pertinent transfer data are given. The Transfer Overview section provides a general perspective for technology transfer from NASA to other organizations. In addition to a description of the basic transfer modes, the selection criteria for notebook examples and the kinds of benefit data they contain are also presented.

Spinoff, 1992

NASA Technical Reports Server (NTRS)

Haggerty, James J.

1992-01-01

This publication is intended to foster the aim of the NASA Technology Transfer Program by heightening awareness of the NASA technology available for reapplication and its potential for public benefit. The publication is organized in three main sections. Section 1 outlines NASA's mainline effort, the major programs that generate new technology and therefore replenish and expand the bank of knowledge available for transfer. Section 2 contains a representative sampling of spinoff products that resulted from secondary application of technology originally developed to meet mainline goals. Section 3 describes the various mechanisms NASA employs to stimulate technology transfer and lists, in an appendix, contact sources for further information about the Technology Transfer Program.

Spinoff 1993

NASA Technical Reports Server (NTRS)

Haggerty, James J.

1993-01-01

This publication is intended to foster the aim of the NASA Technology Transfer Program by heightening awareness of the NASA technology available for reapplication and its potential for public benefit. The publication is organized in three main sections. Section 1 outlines NASA's mainline effort, the major programs that generate new technology and therefore replenish and expand the bank of knowledge available for transfer. Section 2 contains a representative sampling of spinoff products that resulted from secondary application of technology originally developed to meet mainline goals. Section 3 describes the various mechanisms NASA employs to stimulate technology transfer and lists, in an appendix, contact sources for further information about the Technology Transfer Program.

Technology transfer to the broader economy

NASA Technical Reports Server (NTRS)

Dyer, Gordon; Clark, Robert

1992-01-01

Approaches to the transfer of government-funded civil space technology to the broader commercial economy were addressed by Working Panel no. 4. Some of the problems related to current strategies for technology transfer and recommendations for new approaches are described in outline form.

Technology Transfer: Technocultures, Power and Communication--The Australian Experience.

ERIC Educational Resources Information Center

More, Elizabeth; Irwin, Harry

1995-01-01

Discusses issues of communication and power in the organizational dimensions of international technology transfer, including technoculture differences and strategic political alliances. Theoretical discussion is supplemented by analysis of international technology transfer activities involving Australian participation in the aerospace and…

48 CFR 970.2770 - Technology Transfer.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Technology Transfer. 970.2770 Section 970.2770 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2770 Technology Transfer. ...

48 CFR 970.2770 - Technology Transfer.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Technology Transfer. 970.2770 Section 970.2770 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2770 Technology Transfer. ...

48 CFR 970.2770 - Technology Transfer.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Technology Transfer. 970.2770 Section 970.2770 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2770 Technology Transfer. ...

48 CFR 970.2770 - Technology Transfer.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Technology Transfer. 970.2770 Section 970.2770 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2770 Technology Transfer. ...

48 CFR 970.2770 - Technology Transfer.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Technology Transfer. 970.2770 Section 970.2770 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Patents, Data, and Copyrights 970.2770 Technology Transfer. ...

United States Department of Agriculture-Agricultural Research Service: advances in the molecular genetic analysis of insects and their application to pest management.

PubMed

Handler, Alfred M; Beeman, Richard W

2003-01-01

USDA-ARS scientists have made important contributions to the molecular genetic analysis of agriculturally important insects, and have been in the forefront of using this information for the development of new pest management strategies. Advances have been made in the identification and analysis of genetic systems involved in insect development, reproduction and behavior which enable the identification of new targets for control, as well as the development of highly specific insecticidal products. Other studies have been on the leading edge of developing gene transfer technology to better elucidate these biological processes though functional genomics and to develop new transgenic strains for biological control. Important contributions have also been made to the development and use of molecular markers and methodologies to identify and track insect populations. The use of molecular genetic technology and strategies will become increasingly important to pest management as genomic sequencing information becomes available from important pest insects, their targets and other associated organisms.

Applications of aerospace technology in industry. A technology transfer profile: Food technology

NASA Technical Reports Server (NTRS)

Murray, D. M.

1971-01-01

Food processing and preservation technologies are reviewed, expected technological advances are considered including processing and market factors. NASA contributions to food technology and nutrition are presented with examples of transfer from NASA to industry.

[Conceptual foundations of creation of branch database of technology and intellectual property rights owned by scientific institutions, organizations, higher medical educational institutions and enterprises of healthcare sphere of Ukraine].

PubMed

Horban', A Ie

2013-09-01

The question of implementation of the state policy in the field of technology transfer in the medical branch to implement the law of Ukraine of 02.10.2012 No 5407-VI "On Amendments to the law of Ukraine" "On state regulation of activity in the field of technology transfers", namely to ensure the formation of branch database on technology and intellectual property rights owned by scientific institutions, organizations, higher medical education institutions and enterprises of healthcare sphere of Ukraine and established by budget are considered. Analysis of international and domestic experience in the processing of information about intellectual property rights and systems implementation support transfer of new technologies are made. The main conceptual principles of creation of this branch database of technology transfer and branch technology transfer network are defined.

Ames Lab 101: Technology Transfer

ScienceCinema

Covey, Debra

2017-12-13

Ames Laboratory Associate Laboratory Director, Sponsored Research Administration, Debra Covey discusses technology transfer. Covey also discusses Ames Laboratory's most successful transfer, lead-free solder.

Aerospace technology transfer to the public sector; Proceedings of the Conference, Crystal City, Va., November 9-11, 1977

NASA Technical Reports Server (NTRS)

Grey, J. (Editor); Newman, M.

1978-01-01

The dynamics of aerospace technology transfer is discussed with reference to the agencies which facilitate the transfer to both the public and private sectors. Attention is given to NASA's Technology Utilization Program, and to specific applications of aerospace technology spinoff in the daily life of Americans.

14 CFR 1274.915 - Restrictions on sale or transfer of technology to foreign firms or institutions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... technology to foreign firms or institutions. 1274.915 Section 1274.915 Aeronautics and Space NATIONAL... Conditions § 1274.915 Restrictions on sale or transfer of technology to foreign firms or institutions. Restrictions on Sale or Transfer of Technology to Foreign Firms or Institutions July 2002 (a) The parties agree...

75 FR 80830 - Proposed Collection; Comment Request; Technology Transfer Center External Customer Satisfaction...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

... Request; Technology Transfer Center External Customer Satisfaction Survey (NCI) SUMMARY: In compliance...: Technology Transfer Center External Customer Satisfaction Survey (NCI). Type of Information Collection...: Obtain information on the satisfaction of TTC's external customers with TTC customer services; collect...

Technology Transfer and Technology Transfer Intermediaries

ERIC Educational Resources Information Center

Bauer, Stephen M.; Flagg, Jennifer L.

2010-01-01

A standard and comprehensive model is needed to evaluate and compare technology transfer systems and the stakeholders within these systems. The principle systems considered include federal laboratories, U.S. universities, the rehabilitation engineering research centers (RERCs), and large small business innovation research programs. An earlier…

Summary Report on Federal Laboratory Technology Transfer: FY 2003 Activity Metrics and Outcomes. 2004 Report to the President and the Congress under the Technology Transfer and Commercialization Act

DTIC Science & Technology

2004-12-01

Agency, FY 1999-2003 Table 1.1 – Overview of the Types of Information on Federal lab Technology Transfer Collected in the...invention disclosure, patenting, and licensing. Table 1.1 – Overview of the Types of Information on Federal Lab Technology Transfer Collected in...results. In addition, ARS hosts a Textile Manufacturing Symposium and a Cotton Ginning Symposium at gin and textile labs to benefit county extension

Training Technology Transfer Act of 1984. Hearing before the Subcommittee on Education, Arts and Humanities of the Committee on Labor and Human Resources, United States Senate, Ninety-Eighth Congress, Second Session on S. 2561. Entitled the "Training Technology Transfer Act of 1984."

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

This is a congressional hearing on the Training Technology Transfer Act of 1984, which would establish a mechanism for transferring the Federal Government's investment in computer programming for training systems to those organizations and groups that can use such technology in training the civilian work force. Focus is on refining this bill,…

Photovoltaic power - An important new energy option

NASA Technical Reports Server (NTRS)

Ferber, R. R.

1983-01-01

A review of photovoltaic (PV) power technology is presented with an emphasis of PV as an economical and technically feasible alternative source of energy. The successful completion of the development and transfer of emerging low-cost technologies into a fully commercialized status are identified as the means to the realization of this option's full potential. The DOE National Photovoltaics Program, a significant sponsor of PV R&D, expects both flat-plate and concentrator collectors to meet established cost targets. Citing the DOE large flat-plate grid-connected system project of the Sacramento Municipal Utility District, current technology modules priced at near $5/Wp (1983 dollars) are steadily reducing costs. A recent DOE study suggests that PV-generated electricity produced at a 30-year levelized cost of 15 cents per kWh would represent a viable energy supply alternative for the nation.

Photovoltaic power - An important new energy option

NASA Astrophysics Data System (ADS)

Ferber, R. R.

1983-12-01

A review of photovoltaic (PV) power technology is presented with an emphasis of PV as an economical and technically feasible alternative source of energy. The successful completion of the development and transfer of emerging low-cost technologies into a fully commercialized status are identified as the means to the realization of this option's full potential. The DOE National Photovoltaics Program, a significant sponsor of PV R&D, expects both flat-plate and concentrator collectors to meet established cost targets. Citing the DOE large flat-plate grid-connected system project of the Sacramento Municipal Utility District, current technology modules priced at near $5/Wp (1983 dollars) are steadily reducing costs. A recent DOE study suggests that PV-generated electricity produced at a 30-year levelized cost of 15 cents per kWh would represent a viable energy supply alternative for the nation.

The ESA TTP and Recent Spin-off Successes

NASA Astrophysics Data System (ADS)

Raitt, D.; Brisson, P.

2002-01-01

In the framework of its research and development activities, the European Space Agency (ESA) spends some 250m each year and, recognizing the enormous potential of the know-how developed within its R&D activities, set up a Technology Transfer Programme (TTP) some twelve years ago. Over the years, the Programme has achieved some remarkable results with 120 successful transfers of space technologies to the non-space sector; over 120m received by companies making the technologies available; some 15 new companies established as a direct result of exploiting technologies; nearly 2500 jobs created or saved in Europe; and a portfolio of some 300 (out of over 600) active space technologies available for transfer and licencing. Some of the more recent technologies which have been successfully transferred to the non-space sector include the Mamagoose baby safety pyjamas; a spectrographic system being used to compare colours in fabrics and textiles; Earth observation technology employed to assess remotely how much agrochemicals are being used by farmers; and the Dutch solar car, Nuna, which, using European space technologies, finished first in the 2001 World Solar Challenge breaking all records. The paper will give a brief overview of the ESA Technology Transfer Programme and describe some of its recent successful technology transfers.

Short-term perceptual learning in visual conjunction search.

PubMed

Su, Yuling; Lai, Yunpeng; Huang, Wanyi; Tan, Wei; Qu, Zhe; Ding, Yulong

2014-08-01

Although some studies showed that training can improve the ability of cross-dimension conjunction search, less is known about the underlying mechanism. Specifically, it remains unclear whether training of visual conjunction search can successfully bind different features of separated dimensions into a new function unit at early stages of visual processing. In the present study, we utilized stimulus specificity and generalization to provide a new approach to investigate the mechanisms underlying perceptual learning (PL) in visual conjunction search. Five experiments consistently showed that after 40 to 50 min of training of color-shape/orientation conjunction search, the ability to search for a certain conjunction target improved significantly and the learning effects did not transfer to a new target that differed from the trained target in both color and shape/orientation features. However, the learning effects were not strictly specific. In color-shape conjunction search, although the learning effect could not transfer to a same-shape different-color target, it almost completely transferred to a same-color different-shape target. In color-orientation conjunction search, the learning effect partly transferred to a new target that shared same color or same orientation with the trained target. Moreover, the sum of transfer effects for the same color target and the same orientation target in color-orientation conjunction search was algebraically equivalent to the learning effect for trained target, showing an additive transfer effect. The different transfer patterns in color-shape and color-orientation conjunction search learning might reflect the different complexity and discriminability between feature dimensions. These results suggested a feature-based attention enhancement mechanism rather than a unitization mechanism underlying the short-term PL of color-shape/orientation conjunction search.

Space benefits: The secondary application of aerospace technology in other sectors of the economy

NASA Technical Reports Server (NTRS)

1976-01-01

A 'Benefit Briefing Notebook' was prepared for the NASA Technology Utilization Office to provide accurate, convenient, and integrated resource information on the transfer of aerospace technology to other sectors of the U.S. economy. The contents are divided into three sections: (1) transfer overview, (2) benefit cases, and (3) indexes. The transfer overview section provides a general perspective for technology transfer from NASA to other organizations. In addition to a description of the basic transfer modes, the selection criteria for notebook examples and the kinds of benefit data they contain are also presented. The benefits section is subdivided into nineteen subject areas. Each subsection presents one or more key issues of current interest, with discrete transfer cases related to each key issue. Additional transfer examples relevant to each subject area are then presented. Pertinent transfer data are given at the end of each example.

Commercial non-aerospace technology transfer program for the 2000s: Strategic analysis and implementation

NASA Technical Reports Server (NTRS)

Horsham, Gary A. P.

1992-01-01

This report presents a strategic analysis and implementation plan for NASA's Office of Commercial Programs (OCP), Technology Transfer Division's (TTD), Technology Transfer Program. The main objectives of this study are to: (1) characterize the NASA TTD's environment and past organizational structure; (2) clearly identify current and prospective programmatic efforts; (3) determine an evolutionary view of an organizational structure which could lead to the accomplishment of NASA's future technology transfer aims; and (4) formulate a strategy and plan to improve NASA's (and other federal agencies) ability to transfer technology to the non-aerospace sectors of the U.S. economy. The planning horizon for this study extends through the remainder of the 1990s to the year 2000.

Biomedical applications of aerospace technology

NASA Technical Reports Server (NTRS)

Castles, T. R.

1971-01-01

Aerospace technology transfer to biomedical research problems is discussed, including transfer innovations and potential applications. Statistical analysis of the transfer activities and impact is also presented.

"Trojan Horse" strategy for deconstruction of biomass for biofuels production.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinclair, Michael B.; Hadi, Masood Z.; Timlin, Jerilyn Ann

2008-08-01

Production of renewable biofuels to displace fossil fuels currently consumed in the transportation sector is a pressing multi-agency national priority. Currently, nearly all fuel ethanol is produced from corn-derived starch. Dedicated 'energy crops' and agricultural waste are preferred long-term solutions for renewable, cheap, and globally available biofuels as they avoid some of the market pressures and secondary greenhouse gas emission challenges currently facing corn ethanol. These sources of lignocellulosic biomass are converted to fermentable sugars using a variety of chemical and thermochemical pretreatments, which disrupt cellulose and lignin cross-links, allowing exogenously added recombinant microbial enzymes to more efficiently hydrolyze themore » cellulose for 'deconstruction' into glucose. This process is plagued with inefficiencies, primarily due to the recalcitrance of cellulosic biomass, mass transfer issues during deconstruction, and low activity of recombinant deconstruction enzymes. Costs are also high due to the requirement for enzymes and reagents, and energy-intensive and cumbersome pretreatment steps. One potential solution to these problems is found in synthetic biology; they propose to engineer plants that self-produce a suite of cellulase enzymes targeted to the apoplast for cleaving the linkages between lignin and cellulosic fibers; the genes encoding the degradation enzymes, also known as cellulases, are obtained from extremophilic organisms that grow at high temperatures (60-100 C) and acidic pH levels (<5). These enzymes will remain inactive during the life cycle of the plant but become active during hydrothermal pretreatment i.e., elevated temperatures. Deconstruction can be integrated into a one-step process, thereby increasing efficiency (cellulose-cellulase mass-transfer rates) and reducing costs. The proposed disruptive technologies address biomass deconstruction processes by developing transgenic plants encoding a suite of enzymes used in cellulosic deconstruction. The unique aspects of this technology are the rationally engineered, highly productive extremophilic enzymes, targeted to specific cellular locations (apoplast) and their dormancy during normal plant proliferation, which become Trojan horses during pretreatment conditions. They have been leveraging established Sandia's enzyme-engineering and imaging capabilities. Their technical approach not only targets the recalcitrance and mass-transfer problem during biomass degradation but also eliminates the costs associated with industrial-scale production of microbial enzymes added during processing.« less

Partnering Events | NCI Technology Transfer Center | TTC

Cancer.gov

Our team of technology transfer specialists has specialized training in invention reporting, patenting, patent strategy, executing technology transfer agreements and marketing. TTC is comprised of professionals with diverse legal, scientific, and business/marketing expertise. Most of our staff hold doctorate-level technical and/or legal training.

40 CFR 63.126 - Transfer operations provisions-reference control technology.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 9 2011-07-01 2011-07-01 false Transfer operations provisions-reference control technology. 63.126 Section 63.126 Protection of Environment ENVIRONMENTAL PROTECTION... Wastewater § 63.126 Transfer operations provisions—reference control technology. (a) For each Group 1...

40 CFR 63.126 - Transfer operations provisions-reference control technology.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 10 2012-07-01 2012-07-01 false Transfer operations provisions-reference control technology. 63.126 Section 63.126 Protection of Environment ENVIRONMENTAL PROTECTION... Wastewater § 63.126 Transfer operations provisions—reference control technology. (a) For each Group 1...

40 CFR 63.126 - Transfer operations provisions-reference control technology.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 10 2013-07-01 2013-07-01 false Transfer operations provisions-reference control technology. 63.126 Section 63.126 Protection of Environment ENVIRONMENTAL PROTECTION... Wastewater § 63.126 Transfer operations provisions—reference control technology. (a) For each Group 1...

40 CFR 63.126 - Transfer operations provisions-reference control technology.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Transfer operations provisions-reference control technology. 63.126 Section 63.126 Protection of Environment ENVIRONMENTAL PROTECTION... Wastewater § 63.126 Transfer operations provisions—reference control technology. (a) For each Group 1...

Standards Development Activities at White Sands Test Facility

NASA Technical Reports Server (NTRS)

Baker, D. L.; Beeson, H. D.; Saulsberry, R. L.; Julien, H. L.; Woods, S. S.

2003-01-01

The development of standards and standard activities at the JSC White Sands Test Facility (WSTF) has been expanded to include the transfer of technology and standards to voluntary consensus organizations in five technical areas of importance to NASA. This effort is in direct response to the National Technology Transfer Act designed to accelerate transfer of technology to industry and promote government-industry partnerships. Technology transfer is especially important for WSTF, whose longterm mission has been to develop and provide vital propellant safety and hazards information to aerospace designers, operations personnel, and safety personnel. Meeting this mission is being accomplished through the preparation of consensus guidelines and standards, propellant hazards analysis protocols, and safety courses for the propellant use of hydrogen, oxygen, and hypergols, as well as the design and inspection of spacecraft pressure vessels and the use of pyrovalves in spacecraft propulsion systems. The overall WSTF technology transfer program is described and the current status of technology transfer activities are summarized.

NASA's Chemical Transfer Propulsion Program for Pathfinder

NASA Technical Reports Server (NTRS)

Hannum, Ned P.; Berkopec, Frank D.; Zurawski, Robert L.

1989-01-01

Pathfinder is a research and technology project, with specific deliverables, initiated by the National Aeronautics and Space Administration (NASA) which will strengthen the technology base of the United States civil space program in preparation for future space exploration missions. Pathfinder begins in Fiscal Year 1989, and is to advance a collection of critical technologies for these missions and ensure technology readiness for future national decisions regarding exploration of the solar system. The four major thrusts of Pathfinder are: surface exploration, in-space operations, humans-in-space, and space transfer. The space transfer thrust will provide the critical technologies needed for transportation to, and return from, the Moon, Mars, and other planets in the solar system, as well as for reliable and cost-effective Earth-orbit operations. A key element of this thrust is the Chemical Transfer Propulsion program which will provide the propulsion technology for high performance, liquid oxygen/liquid hydrogen expander cycle engines which may be operated and maintained in space. Described here are the program overview including the goals and objectives, management, technical plan, and technology transfer for the Chemical Transfer Propulsion element of Pathfinder.

Strategies for Maximizing Successful Drug Substance Technology Transfer Using Engineering, Shake-Down, and Wet Test Runs.

PubMed

Abraham, Sushil; Bain, David; Bowers, John; Larivee, Victor; Leira, Francisco; Xie, Jasmina

2015-01-01

The technology transfer of biological products is a complex process requiring control of multiple unit operations and parameters to ensure product quality and process performance. To achieve product commercialization, the technology transfer sending unit must successfully transfer knowledge about both the product and the process to the receiving unit. A key strategy for maximizing successful scale-up and transfer efforts is the effective use of engineering and shake-down runs to confirm operational performance and product quality prior to embarking on good manufacturing practice runs such as process performance qualification runs. We consider key factors to consider in making the decision to perform shake-down or engineering runs. We also present industry benchmarking results of how engineering runs are used in drug substance technology transfers alongside the main themes and best practices that have emerged. Our goal is to provide companies with a framework for ensuring the "right first time" technology transfers with effective deployment of resources within increasingly aggressive timeline constraints. © PDA, Inc. 2015.

Conceptual and empirical themes regarding the design of technology transfer programs : a review of wood utilization research in the United States

Treesearch

Paul V. Ellefson; Michael A. Kilgore; Kenneth E. Skog; Christopher D. Risbrudt

2011-01-01

Transfer of technologies produced by research is critical to innovation within all organizations. The intent of this paper is to take stock of the conceptual underpinnings of technology transfer processes as they relate to wood utilization research and to identify conditions that promote the successful transfer of research results. Conceptually, research utilization...

How to tap NASA-developed technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruzic, N.

The National Aeronautics and Space Administration (NASA) space program's contribution to technology and the transfer of its achievements to industrial and consumer products is unprecedented. The process of transferring new technology suffers, however, partly because managers tend to ignore new technological markets unless new products solve their specific problems and partly because managers may not know the technology is available. NASA's Technology Utilization Branch has learned to initiate transfer, using a network of centers to dispense information on applications. NASA also has a large software library and computer programs, as well as teams to make person-to-person contacts. Examples of successfulmore » transfers have affected energy sources, building contruction, health, and safety. (DCK)« less

FY 2004 Technology Transfer Network and Affiliations

NASA Technical Reports Server (NTRS)

2004-01-01

The NASA Innovative Partnerships Program sponsors a number of organizations around the country that are designed to assist U.S. businesses in accessing, utilizing, and commercializing NASA-funded research and technology. These organizations work closely with the Technology Transfer Offices, located at each of the 10 NASA field centers, providing a full range of technology transfer and commercialization services and assistance.

T-DNA transfer and integration in the ectomycorrhizal fungus Suillus bovinus using hygromycin B as a selectable marker.

PubMed

Hanif, Mubashir; Pardo, Alejandro Guillermo; Gorfer, Markus; Raudaskoski, Marjatta

2002-06-01

The T-DNA of Agrobacterium tumefaciens can be transferred to plants, yeasts, fungi and human cells. Using this system, dikaryotic mycelium of the ectomycorrhizal fungus Suillus bovinus was transformed with recombinant hygromycin B phosphotransferase (hph)and enhanced green fluorescent protein (EGFP) genes fused with a heterologous fungal promoter and CaMV35S terminator. Transformation resulted in hygromycin B-resistant clones, which were mitotically stable. Putative transformants were analysed for the presence of hph and EGFP genes by PCR and Southern analysis. The latter analysis proved both multiple- and single-copy integrations of the genes in the S. bovinus genome. A. tumeficiens transformation should make possible the development of tagged mutagenesis and targeted gene disruption technology for S. bovinus.

Identifying research needs for wheelchair transfers in the built environment.

PubMed

Crytzer, Theresa Marie; Cooper, Rory; Jerome, Genevieve; Koontz, Alicia

2017-02-01

The purpose of this study is to describe the results of focus groups held during the Independent Wheelchair Transfer (IWT) Workgroup. The aims were to facilitate exchange of ideas on (1) the impact of the built environment on the wheelchair transfer process within the community (i.e. moving from wheelchair to and from other surfaces (e.g. furniture, toilet seat, bath bench, car seat) to participate in daily activities), (2) wheelchair users' needs during transfers in the built environment, and (3) future research directions. Live web-based conferencing using Adobe Connect technology (Clarix Technologies, Inc., Pittsford, NY) was utilized to conduct three focus groups composed of experts in the field of assistive technology. Investigators independently reviewed focus group meeting transcripts and used qualitative methods to identify main themes. Thirty-one experts in assistive technology and related fields participated in focus groups. Nine main themes were found including the effect of transfer skills training, space considerations in the built environment, wheelchair configuration, and the interaction between the built environment, user preferences, and transfer techniques. All groups raised issues about the transfer process in areas of the built environment with limited access, the effect of wheelchair users' transfer techniques, and user preferences during transfers. The area of independent transfers is multi-faceted and several factors require consideration when contemplating environmental changes to improve accessibility for wheelchair users. Obvious opportunity exists for research which could lead to advances in transfer technology, environments, and techniques for wheelchair users. Implications for Rehabilitation Tremendous opportunities for research collaborations in the field of assistive technology: To develop new terminology to describe wheelchair transfers. To improve the design of the built environment for wheelchair users. To investigate wheelchair transfer training techniques.

Cancer vaccine development: Designing tumor cells for greater immunogenicity

PubMed Central

Bozeman, Erica N.; Shashidharamurthy, Rangaiah; Paulos, Simon A.; Palaniappan, Ravi; D’Souza, Martin; Selvaraj, Periasamy

2014-01-01

Cancer vaccine development is one of the most hopeful and exhilarating areas in cancer research. For this reason, there has been a growing interest in the development and application of novel immunotherapies for the treatment of cancer with the focus being on stimulating the immune system to target tumor cells specifically while leaving normal cells unharmed. From such research has emerged a host of promising immunotherapies such as dendritic cell-based vaccines, cytokine therapies and gene transfer technology. These therapies seek to counteract the poor immunogenicity of tumors by augmenting the host’s immune system with a variety of immunostimulatory proteins such as cytokines and costimulatory molecules. While such therapies have proven effective in the induction of anti-tumor immunity in animal models, they are less than optimal and pose a high risk of clinical infeasibility. Herein, we further discuss these immunotherapies as well as a feasible and efficient alternative that, in pre-clinical animal models, allows for the expression of specific immunostimulatory molecules on the surface of tumor cells by a novel protein transfer technology. PMID:20036822

International trade in live molluscs: perspective from the Americas.

PubMed

Elston, R A

1996-06-01

There is an active world trade in seed and edible molluscs, including such species as oysters, abalones, clams, scallops, and mussels. The supply of new and effectively-produced products, such as triploid oyster seed, is likely to increase due to greater world-wide demand for these high-value products, together with improved technology. Transfer to live molluscs is driven by need an availability, with concern over infectious disease risks often playing subordinate role or serving to support economic trade barriers. Experience shows that serious risks from infectious disease transfer exist. Technology and balanced management, however, can limit such risks. Separation of biological risks from trade control objectives is a necessary first step. A systematic method of risk analysis is urgently needed, along with predefined actions which can be adapted to the various risk levels. Critical to the effective development and implementation of this risk analysis is the participation of the shellfish industry in defining risks and actions. Organization and infrastructure to improve recognition of infectious diseases and decrease response time are necessary improvements, together with appropriately-targeted research on impacts, diagnosis, epidemiology, carrier status, and geographical distribution of diseases.

Strategic Planning of Technology Transfer.

ERIC Educational Resources Information Center

Groff, Warren H.

Using the Ohio Technology Transfer Organization (OTTO) as its primary example, this paper offers a strategic planning perspective on technology transfer and human resources development. First, a brief overview is provided of the maturation of mission priorities and planning processes in higher education in the United States, followed by a…

Teacher Candidate Technology Integration: For Student Learning or Instruction?

ERIC Educational Resources Information Center

Clark, Cynthia; Zhang, Shaoan; Strudler, Neal

2015-01-01

Transfer of instructional technology knowledge for student-centered learning by teacher candidates is investigated in this study. Using the transfer of learning theoretical framework, a mixed methods research design was employed to investigate whether secondary teacher candidates were able to transfer the instructional technology knowledge for…

76 FR 8371 - Notice Correction; Generic Submission of Technology Transfer Center (TTC) External Customer...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

... Submission of Technology Transfer Center (TTC) External Customer Satisfaction Surveys (NCI) The Federal... project titled, ``Technology Transfer Center (TTC) External Customer Satisfaction Survey (NCI)'' was... will include multiple customer satisfaction surveys over the course of three years. At this time, only...

Proceedings: international conference on transfer of forest science knowledge and technology.

Treesearch

Cynthia Miner; Ruth Jacobs; Dennis Dykstra; Becky Bittner

2007-01-01

This proceedings compiles papers presented by extensionists, natural resource specialists, scientists, technology transfer specialists, and others at an international conference that examined knowledge and technology transfer theories, methods, and case studies. Theory topics included adult education, applied science, extension, diffusion of innovations, social...

Pacing a data transfer operation between compute nodes on a parallel computer

DOEpatents

Blocksome, Michael A [Rochester, MN

2011-09-13

Methods, systems, and products are disclosed for pacing a data transfer between compute nodes on a parallel computer that include: transferring, by an origin compute node, a chunk of an application message to a target compute node; sending, by the origin compute node, a pacing request to a target direct memory access (`DMA`) engine on the target compute node using a remote get DMA operation; determining, by the origin compute node, whether a pacing response to the pacing request has been received from the target DMA engine; and transferring, by the origin compute node, a next chunk of the application message if the pacing response to the pacing request has been received from the target DMA engine.

Treating Cancer with Genetically Engineered T Cells

PubMed Central

Park, Tristen S.; Rosenberg, Steven A.; Morgan, Richard A.

2011-01-01

Administration of ex-vivo cultured, naturally occurring tumor-infiltrating lymphocytes (TILs) have been shown to mediate durable regression of melanoma tumors. However, the generation of TIL is not possible in all patients and there has been limited success in generating TIL in other cancers. Advances in genetic engineering have overcome these limitations by introducing tumor-antigen-targeting receptors into human T lymphocytes. Physicians can now genetically engineer lymphocytes to express highly active T-cell receptors (TCRs) or chimeric antigen receptors (CARs) targeting a variety of tumor antigens expressed in cancer patients. In this review we discuss the development of TCR and CAR gene transfer technology and the expansion of these therapies into different cancers with the recent demonstration of the clinical efficacy of these treatments. PMID:21663987

Identification and evaluation of fluvial-dominated deltaic (Class I oil) reservoirs in Oklahoma. Quarterly technical progress report, January 1, 1993--March 31, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankin, C.J.; Grasmick, M.K.

The Oklahoma Geological Survey (OGS), the Geological Information Systems department, and the School of Petroleum and Geological Engineering at the University of Oklahoma have engaged in a program to identify and address Oklahoma`s oil recovery opportunities in fluvial-dominated deltaic (FDD) reservoirs. This program includes the systematic and comprehensive collection and evaluation of information on all of Oklahoma`s FDD reservoirs and the recovery technologies that have been (or could be) applied to those reservoirs with commercial success. This data collection and evaluation effort will be the foundation for an aggressive, multifaceted technology transfer program that is designed to support all ofmore » Oklahoma`s oil industry, with particular emphasis on smaller companies and independent operators in their attempts to maximize the economic producibility of FDD reservoirs. Specifically, this project will identify all FDD oil reservoirs in the State; group those reservoirs into plays that have similar depositional and subsequent geologic histories; collect, organize and analyze all available data; conduct characterization and simulation studies on selected reservoirs in each play; and implement a technology transfer program targeted to the operators of FDD reservoirs to sustain the life expectancy of existing wells with the ultimate objective of increasing oil recovery.« less

Identification and evaluation of fluvial-dominated deltaic (Class I Oil). Quarterly technical progress report, April 1, 1995--June 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankin, C.J.; Banken, M.K.

The Oklahoma Geological Survey (OGS), the Geo Information Systems department, and the School of Petroleum and Geological Engineering at the University of Oklahoma are engaged in a program to identify and address Oklahoma`s oil recovery opportunities in fluvial-dominated deltaic (FDD) reservoirs. This program includes the systematic and comprehensive collection and evaluation of information on all of Oklahoma`s FDD reservoirs and the recovery technologies that have been (or could be) applied to those reservoirs with commercial success. This data collection and evaluation effort will be the foundation for an aggressive, multifaceted technology transfer program that is designed to support all ofmore » Oklahoma`s oil industry, with particular emphasis on smaller companies and independent operators in their attempts to maximize the economic producibility of FDD reservoirs. Specifically, this project will identify all FDD oil reservoirs in the State; group those reservoirs into plays that have similar depositional and subsequent geologic histories; collect, organize and analyze all available data; conduct characterization and simulation studies on selected reservoirs in each play; and implement a technology transfer program targeted to the operators of FDD reservoirs to sustain the life expectancy of existing wells with the ultimate objective of increasing oil recovery.« less

Identification and evaluation of fluvial-dominated deltaic (Class 1 oil) reservoirs in Oklahoma. Quarterly technical progress report, October 1, 1994--December 31, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankin, C.J.; Banken, M.K.

The Oklahoma Geological Survey (OGS), the Geological Information Systems department, and the School of Petroleum and Geological Engineering at the University of Oklahoma are engaging in a program to identify and address Oklahoma`s oil recovery opportunities in fluvial-dominated deltaic (FDD) reservoirs. This program includes the systematic and comprehensive collection and evaluation of information on all of Oklahoma`s FDD reservoirs and the recovery technologies that have been (or could be) applied to those reservoirs with commercial success. This data collection and evaluation effort will be the foundation for an aggressive, multifaceted technology transfer program that is designed to support all ofmore » Oklahoma`s oil industry, with particular emphasis on smaller companies and independent operators in their attempts to maximize the economic producibility of FDD reservoirs. Specifically, this project will identify all FDD oil reservoirs in the State; group those reservoirs into plays that have similar depositional and subsequent geologic histories; collect, organize and analyze all available data; conduct characterization and simulation studies on selected reservoirs in each play; and implement a technology transfer program targeted to the operators of FDD reservoirs to sustain the life expectancy of existing wells with the ultimate objective of increasing oil recovery.« less

Identification and evaluation of fluvial-dominated deltaic (class 1 oil) reservoirs in Oklahoma. Quarterly technical progress report, July 1, 1993--September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankin, C.J.; Banken, M.K.

The Oklahoma Geological Survey (OGS), the Geological Information Systems department, and the School of Petroleum and Geological Engineering at the University of Oklahoma are engaging in a program to identify and address Oklahoma`s oil recovery opportunities in fluvial-dominated deltaic (FDD) reservoirs. This program includes the systematic and comprehensive collection and evaluation of information on all of Oklahoma`s FDD reservoirs and the recovery technologies that have been (or could be) applied to those reservoirs with commercial success. This data collection and evaluation effort will be the foundation for an aggressive, multifaceted technology transfer program that is designed to support all ofmore » Oklahoma`s oil industry, with particular emphasis on smaller companies and independent operators in their attempts to maximize the economic producibility of FDD reservoirs. Specifically, this project will identify all FDD oil reservoirs in the State; group those reservoirs into plays that have similar depositional and subsequent geologic histories; collect, organize and analyze all available data; conduct characterization and simulation studies on selected reservoirs in each play; and implement a technology transfer program targeted to the operators of FDD reservoirs to sustain the life expectancy of existing wells with the ultimate objective of increasing oil recovery.« less

Identification and evaluation of fluvial-dominated deltaic (Class I oil) reservoirs in Oklahoma. Quarterly technical progress report, April 1, 1993--June 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mankin, G.J.; Banken, M.K.

The Oklahoma Geological Survey (OGS), the Geological Information Systems department, and the School of Petroleum and Geological Engineering at the University of Oklahoma are engaging in a program to identify and address Oklahoma`s oil recovery opportunities in fluvial-dominated deltaic (FDD) reservoirs. This program includes the systematic and comprehensive collection and evaluation of information on all of Oklahoma`s FDD reservoirs and the recovery-technologies that have been (or could be) applied to those reservoirs with commercial success. This data collection and evaluation effort will be the foundation for an aggressive, multifaceted technology transfer program that is designed to support all of Oklahoma`smore » oil industry, with particular emphasis on smaller companies and independent operators in their attempts to maximize the economic producibility of FDD reservoirs. Specifically, this project will identify all FDD oil reservoirs in the State; group those reservoirs into plays that have similar depositional and subsequent geologic histories; collect, organize and analyze all available data; conduct characterization and simulation studies on selected reservoirs in each play; and implement a technology transfer program targeted to the operators of FDD reservoirs to sustain the life expectancy of existing wells with the ultimate objective of increasing oil recovery.« less

Object recognition using deep convolutional neural networks with complete transfer and partial frozen layers

NASA Astrophysics Data System (ADS)

Kruithof, Maarten C.; Bouma, Henri; Fischer, Noëlle M.; Schutte, Klamer

2016-10-01

Object recognition is important to understand the content of video and allow flexible querying in a large number of cameras, especially for security applications. Recent benchmarks show that deep convolutional neural networks are excellent approaches for object recognition. This paper describes an approach of domain transfer, where features learned from a large annotated dataset are transferred to a target domain where less annotated examples are available as is typical for the security and defense domain. Many of these networks trained on natural images appear to learn features similar to Gabor filters and color blobs in the first layer. These first-layer features appear to be generic for many datasets and tasks while the last layer is specific. In this paper, we study the effect of copying all layers and fine-tuning a variable number. We performed an experiment with a Caffe-based network on 1000 ImageNet classes that are randomly divided in two equal subgroups for the transfer from one to the other. We copy all layers and vary the number of layers that is fine-tuned and the size of the target dataset. We performed additional experiments with the Keras platform on CIFAR-10 dataset to validate general applicability. We show with both platforms and both datasets that the accuracy on the target dataset improves when more target data is used. When the target dataset is large, it is beneficial to freeze only a few layers. For a large target dataset, the network without transfer learning performs better than the transfer network, especially if many layers are frozen. When the target dataset is small, it is beneficial to transfer (and freeze) many layers. For a small target dataset, the transfer network boosts generalization and it performs much better than the network without transfer learning. Learning time can be reduced by freezing many layers in a network.

77 FR 14324 - National Volatile Organic Compound Emission Standards for Aerosol Coatings-Addition of Dimethyl...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

.... National Technology Transfer and Advancement Act Section 12(d) of the National Technology Transfer and... information claimed to be confidential business information (CBI) or other information whose disclosure is... That Significantly Affect Energy Supply, Distribution, or Use I. National Technology Transfer and...

Technology Transfer Educational Curriculum Plan for the State of Colorado.

ERIC Educational Resources Information Center

Dakin, Karl J.

A recommended plan for an educational curriculum on the topic of technology transfer is outlined. A survey was conducted to determine the current levels of ability and knowledge of technology users and of transfer intermediaries. Information was collected from three sources: individuals and organizations currently presenting educational programs…

Technology Transfer: A Selected Bibliography.

ERIC Educational Resources Information Center

Sovel, M. Terry

This bibliography of 428 items, a product of the NASA-sponsored Project for the Analysis of Technology Transfer (PATT) at the University of Denver's Research Institute (DRI), is the initial attempt at compiling a comprehensive listing on the subject of technology transfer. The bibliography is further concerned with information which leads to a…

Food irradiation: Technology transfer in Asia, practical experiences

NASA Astrophysics Data System (ADS)

Kunstadt, Peter; Eng, P.

1993-10-01

Nordion International Inc., in cooperation with the Thai Office of Atomic Energy for Peace (OAEP) and the Canadian International Development Agency (CIDA) recently completed a unique food irradiation technology transfer project in Thailand. This complete food irradiation technology transfer project included the design and construction of an automatic multipurpose irradiation facility as well as the services of construction and installation management and experts in facility operation, maintenance and training. This paper provides an insight into the many events that led to the succesful conclusion of the world's first complete food irradiation technology transfer project.

Societal and economic valuation of technology-transfer deals

NASA Astrophysics Data System (ADS)

Holmes, Joseph S., Jr.

2009-09-01

The industrial adoption of concepts such as open innovation brings new legitimacy to activities technology-transfer professionals have conducted for over 20 years. This movement highlights the need for an increased understanding of the valuation of intellectual property (IP) and technology-transfer deals. Valuation, though a centerpiece of corporate finance, is more challenging when applied to the inherent uncertainty surrounding innovation. Technology-transfer professionals are often overwhelmed by the complexity and data requirements of valuation techniques and skeptical of their applicability to and utility for technology transfer. The market longs for an approach which bridges the gap between valuation fundamentals and technology-transfer realities. This paper presents the foundations of a simple, flexible, precise/accurate, and useful framework for considering the valuation of technology-transfer deals. The approach is predicated on a 12-factor model—a 3×4 value matrix predicated on categories of economic, societal, and strategic value. Each of these three categories consists of three core subcategories followed by a fourth "other" category to facilitate inevitable special considerations. This 12-factor value matrix provides a framework for harvesting data during deals and for the application of best-of-breed valuation techniques which can be employed on a per-factor basis. Future work will include framework implementation within a database platform.

The Diffusion of Military Technologies to Foreign Nations: Arms Transfers Can Preserve the Defense Technological and Industrial Base

DTIC Science & Technology

1995-06-01

required, the Defense Technology Security Administration ( DTSA ) will make a determination on whether or not advanced technologies are being risked by the...sale or transfer of that product. DTSA has this role whether it is a commercial or government-to-government transfer. The Joint Chiefs of Staff also...Office of Defense Relations Security Assistance DSAA Defense Security Assistance Agency DTIB Defense Technological and Industrial Base DTSA Defense

NASA'S Changing Role in Technology Development and Transfer

NASA Technical Reports Server (NTRS)

Griner, Carolyn S.; Craft, Harry G., Jr.

1997-01-01

National Aeronautics and Space Administration NASA has historically had to develop new technology to meet its mission objectives. The newly developed technologies have then been transferred to the private sector to assist US industry's worldwide competitiveness and thereby spur the US economy. The renewed emphasis by the US Government on a proactive technology transfer approach has produced a number of contractual vehicles that assist technology transfer to industrial, aerospace and research firms. NASA's focus has also been on leveraging the shrinking space budget to accomplish "more with less." NASA's cooperative agreements and resource sharing agreements are measures taken to achieve this goal, and typify the changing role of government technology development and transfer with industry. Large commercial partnerships with aerospace firms, as typified by the X-33 and X-34 Programs, are evolving. A new emphasis on commercialization in the Small Business Innovative Research and Dual Use programs paves the way for more rapid commercial application of new technologies developed for NASA.

Streaming support for data intensive cloud-based sequence analysis.

PubMed

Issa, Shadi A; Kienzler, Romeo; El-Kalioby, Mohamed; Tonellato, Peter J; Wall, Dennis; Bruggmann, Rémy; Abouelhoda, Mohamed

2013-01-01

Cloud computing provides a promising solution to the genomics data deluge problem resulting from the advent of next-generation sequencing (NGS) technology. Based on the concepts of "resources-on-demand" and "pay-as-you-go", scientists with no or limited infrastructure can have access to scalable and cost-effective computational resources. However, the large size of NGS data causes a significant data transfer latency from the client's site to the cloud, which presents a bottleneck for using cloud computing services. In this paper, we provide a streaming-based scheme to overcome this problem, where the NGS data is processed while being transferred to the cloud. Our scheme targets the wide class of NGS data analysis tasks, where the NGS sequences can be processed independently from one another. We also provide the elastream package that supports the use of this scheme with individual analysis programs or with workflow systems. Experiments presented in this paper show that our solution mitigates the effect of data transfer latency and saves both time and cost of computation.

[New advances in animal transgenic technology].

PubMed

Sun, Zhen-Hong; Miao, Xiang-Yang; Zhu, Rui-Liang

2010-06-01

Animal transgenic technology is one of the fastest growing biotechnology in the 21st century. It is used to integrate foreign genes into the animal genome by genetic engineering technology so that foreign genes can be expressed and inherited to the offspring. The transgenic efficiency and precise control of gene expression are the key limiting factors on preparation of transgenic animals. A variety of transgenic techniques are available, each of which has its own advantages and disadvantages and still needs further study because of unresolved technical and safety issues. With the in-depth research, the transgenic technology will have broad application prospects in the fields of exploration of gene function, animal genetic improvement, bioreactor, animal disease models, organ transplantation and so on. This article reviews the recently developed animal gene transfer techniques, including germline stem cell mediated method to improve the efficiency, gene targeting to improve the accuracy, RNA interference (RNAi)-mediated gene silencing technology, and the induced pluripotent stem cells (iPS) transgenic technology. The new transgenic techniques can provide a better platform for the study of trans-genic animals and promote the development of medical sciences, livestock production, and other fields.

Assessment of RFID Read Accuracy for ISS Water Kit

NASA Technical Reports Server (NTRS)

Chu, Andrew

2011-01-01

The Space Life Sciences Directorate/Medical Informatics and Health Care Systems Branch (SD4) is assessing the benefits Radio Frequency Identification (RFID) technology for tracking items flown onboard the International Space Station (ISS). As an initial study, the Avionic Systems Division Electromagnetic Systems Branch (EV4) is collaborating with SD4 to affix RFID tags to a water kit supplied by SD4 and studying the read success rate of the tagged items. The tagged water kit inside a Cargo Transfer Bag (CTB) was inventoried using three different RFID technologies, including the Johnson Space Center Building 14 Wireless Habitat Test Bed RFID portal, an RFID hand-held reader being targeted for use on board the ISS, and an RFID enclosure designed and prototyped by EV4.

Silver nanoparticle ink technology: state of the art

PubMed Central

Rajan, Krishna; Roppolo, Ignazio; Chiappone, Annalisa; Bocchini, Sergio; Perrone, Denis; Chiolerio, Alessandro

2016-01-01

Printed electronics will bring to the consumer level great breakthroughs and unique products in the near future, shifting the usual paradigm of electronic devices and circuit boards from hard boxes and rigid sheets into flexible thin layers and bringing disposable electronics, smart tags, and so on. The most promising tool to achieve the target depends upon the availability of nanotechnology-based functional inks. A certain delay in the innovation-transfer process to the market is now being observed. Nevertheless, the most widely diffused product, settled technology, and the highest sales volumes are related to the silver nanoparticle-based ink market, representing the best example of commercial nanotechnology today. This is a compact review on synthesis routes, main properties, and practical applications. PMID:26811673

Silver nanoparticle ink technology: state of the art.

PubMed

Rajan, Krishna; Roppolo, Ignazio; Chiappone, Annalisa; Bocchini, Sergio; Perrone, Denis; Chiolerio, Alessandro

2016-01-01

Printed electronics will bring to the consumer level great breakthroughs and unique products in the near future, shifting the usual paradigm of electronic devices and circuit boards from hard boxes and rigid sheets into flexible thin layers and bringing disposable electronics, smart tags, and so on. The most promising tool to achieve the target depends upon the availability of nanotechnology-based functional inks. A certain delay in the innovation-transfer process to the market is now being observed. Nevertheless, the most widely diffused product, settled technology, and the highest sales volumes are related to the silver nanoparticle-based ink market, representing the best example of commercial nanotechnology today. This is a compact review on synthesis routes, main properties, and practical applications.

Field-programmable gate array implementation of an all-digital IEEE 802.15.4-compliant transceiver

NASA Astrophysics Data System (ADS)

Cornetta, Gianluca; Touhafi, Abdellah; Santos, David J.; Vázquez, José M.

2010-12-01

An architecture for a low-cost, low-complexity digital transceiver is presented in this article. The proposed architecture targets the IEEE 802.15.4 standard for short-range wireless personal area networks and has been implemented as a synthesisable VHDL register transfer level description. The system has been evaluated and tested using a Xilinx 90 nm Virtex-4 field-programmable gate array as the target technology. Bit error rate (BER) and error vector magnitude (EVM) have been used as the figures of merit for modem performance. Simulations show that the recommended minimum BER is achieved at E b/N 0 = 8.7 dB, whereas the EVM is 19.5%. The implemented device occupies 10% of the target FPGA and has a normalised maximum power consumption of 44 mW in transmit mode and 53 mW in receiver mode.

Spinoff, 1991

NASA Technical Reports Server (NTRS)

Haggerty, James J.

1991-01-01

This is an instrument of the Technology Utilization Program and is designed to heighten awareness of the technology available for transfer and its potential for public benefit. NASA's mainline programs, whose objectives require development of new technology and therefore expand the bank of technology available for transfer in future years, are summarized. Focus is on the representative sampling of spinoffs (spinoff, in this context, means products and processes developed as secondary applications of existing NASA technology) that resulted from NASA's mainline programs. The various mechanisms NASA employs to stimulate technology transfer are described and contact sources are listed in the appendix for further information about the Technology Utilization Program.

Commercial application of thermal protection system technology

NASA Technical Reports Server (NTRS)

Dyer, Gordon L.

1991-01-01

The thermal protection system process technology is examined which is used in the manufacture of the External Tank for the Space Shuttle system and how that technology is applied by private business to create new products, new markets, and new American jobs. The term 'technology transfer' means different things to different people and has become one of the buzz words of the 1980s and 1990s. Herein, technology transfer is defined as a means of transferring technology developed by NASA's prime contractors to public and private sector industries.

Tech Transfer News. Volume 9, No. 1

NASA Technical Reports Server (NTRS)

Victor, Megan E. (Compiler)

2017-01-01

Kennedy Tech Transfer News is the magazine of the Technology Transfer Office at NASA's Kennedy Space Center, Florida. This magazine seeks to inform and educate civil servant and contractor personnel at Kennedy Space Center about actively participating in achieving NASA's technology transfer and partnership goals.

An improved Red/ET recombineering system and mouse ES cells culture conditions for the generation of targeted mutant mice.

PubMed

Kumagai, Katsuyoshi; Takanashi, Masakatsu; Ohno, Shin-Ichiro; Kuroda, Masahiko; Sudo, Katsuko

2017-05-03

Targeted mutant mice generated on a C57BL/6 background are powerful tools for analysis of the biological functions of genes, and gene targeting technologies using mouse embryonic stem (ES) cells have been used to generate such mice. Recently, a bacterial artificial chromosome (BAC) recombineering system was established for the construction of targeting vectors. However, gene retrieval from BACs for the generation of gene targeting vectors using this system remains difficult. Even when construction of a gene targeting vector is successful, the efficiency of production of targeted mutant mice from ES cells derived from C57BL/6 mice are poor. Therefore, in this study, we first improved the strategy for the retrieval of genes from BACs and their transfer into a DT-A plasmid, for the generation of gene targeting vectors using the BAC recombineering system. Then, we attempted to generate targeted mutant mice from ES cell lines derived from C57BL/6 mice, by culturing in serum-free medium. In conclusion, we established an improved strategy for the efficient generation of targeted mutant mice on a C57BL/6 background, which are useful for the in vivo analysis of gene functions and regulation.

Technology Transfer: Marketing Tomorrow's Technology

NASA Technical Reports Server (NTRS)

Tcheng, Erene

1995-01-01

The globalization of the economy and the end of the Cold War have triggered many changes in the traditional practices of U.S. industry. To effectively apply the resources available to the United States, the federal government has firmly advocated a policy of technology transfer between private industry and government labs, in this case the National Aeronautics and Space Administration (NASA). NASA Administrator Daniel Goldin is a strong proponent of this policy and has organized technology transfer or commercialization programs at each of the NASA field centers. Here at Langley Research Center, the Technology Applications Group (TAG) is responsible for facilitating the transfer of Langley developed research and technology to U.S. industry. Entering the program, I had many objectives for my summer research with TAG. Certainly, I wanted to gain a more thorough understanding of the concept of technology transfer and Langley's implementation of a system to promote it to both the Langley community and the community at large. Also, I hoped to become more familiar with Langley's research capabilities and technology inventory available to the public. More specifically, I wanted to learn about the technology transfer process at Langley. Because my mentor is a member of Materials and Manufacturing marketing sector of the Technology Transfer Team, another overriding objective for my research was to take advantage of his work and experience in materials research to learn about the Advanced Materials Research agency wide and help market these developments to private industry. Through the various projects I have been assigned to work on in TAG, I have successfully satisfied the majority of these objectives. Work on the Problem Statement Process for TAG as well as the development of the Advanced Materials Research Brochure have provided me with the opportunity to learn about the technology transfer process from the outside looking in and the inside looking out. Because TAG covers all of the research efforts conducted at Langley, my studies with TAG were ab!e to provide me an excellent overview of Langley's contribution to the aeronautics industry.

Assessment of research and technology transfer needs for wood-frame housing

Treesearch

Kevin Powell; David Tilotta; Karen Martinson

2008-01-01

Improvements to housing will require both research and the transfer of that research to homebuilders, homebuyers, and others in need of technology. This report summarizes results of a national survey on research and technology transfer needs for housing and prioritizes those needs. Survey participants included academicians, builders, code officials, government...

Successful Technology Transfer in Colorado: A Portfolio of Technology Transfer "Success Stories."

ERIC Educational Resources Information Center

Colorado Advanced Tech. Inst., Denver.

The examples in this portfolio demonstrate how technology transfer among universities, businesses, and federal laboratories solve real-world problems, and create new goods and services. They reveal how, through strengthening the infrastructure joining private and public sectors, Colorado can better compete in the global marketplace. All of the…

Love and Hate in University Technology Transfer: Examining Faculty and Staff Conflicts and Ethical Issues

ERIC Educational Resources Information Center

Hamilton, Clovia; Schumann, David

2016-01-01

With respect to university technology transfer, the purpose of this paper is to examine the literature focused on the relationship between university research faculty and technology transfer office staff. We attempt to provide greater understanding of how research faculty's personal values and research universities' organization values may differ…

A southern region conference on technology transfer and extension

Treesearch

Sarah F. Ashton; William G. Hubbard; H. Michael Rauscher

2009-01-01

Forest landowners and managers have different education and technology transfer needs and preferences. To be effective it is important to use a multi-faceted science delivery/technology transfer program to reach them. Multi-faceted science delivery programs can provide similar content over a wide range of mechanisms including printed publications, face-to-face...

Magnetic field-assisted gene delivery: achievements and therapeutic potential.

PubMed

Schwerdt, Jose I; Goya, Gerardo F; Calatayud, M Pilar; Hereñú, Claudia B; Reggiani, Paula C; Goya, Rodolfo G

2012-04-01

The discovery in the early 2000's that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field, greatly enhance gene transfer into cells has raised much interest. This technique, called magnetofection, was initially developed mainly to improve gene transfer in cell cultures, a simpler and more easily controllable scenario than in vivo models. These studies provided evidence for some unique capabilities of magnetofection. Progressively, the interest in magnetofection expanded to its application in animal models and led to the association of this technique with another technology, magnetic drug targeting (MDT). This combination offers the possibility to develop more efficient and less invasive gene therapy strategies for a number of major pathologies like cancer, neurodegeneration and myocardial infarction. The goal of MDT is to concentrate MNPs functionalized with therapeutic drugs, in target areas of the body by means of properly focused external magnetic fields. The availability of stable, nontoxic MNP-gene vector complexes now offers the opportunity to develop magnetic gene targeting (MGT), a variant of MDT in which the gene coding for a therapeutic molecule, rather than the molecule itself, is delivered to a therapeutic target area in the body. This article will first outline the principle of magnetofection, subsequently describing the properties of the magnetic fields and MNPs used in this technique. Next, it will review the results achieved by magnetofection in cell cultures. Last, the potential of MGT for implementing minimally invasive gene therapy will be discussed.

Applications of aerospace technology in industry. A technology transfer profile: Cryogenics

NASA Technical Reports Server (NTRS)

1971-01-01

Cryogenics is especially interesting when viewed from the perspective of technology transfer. Its recent rapid growth has been due to demands of both industry and aerospace. This environment provides an unusual opportunity to identify some of the forces active during a period of broad technological change and at the same time further the understanding of the technology transfer process. That process is specifically defined here as the ways in which technology, generated in NASA programs, contributes to technological change. In addition to presenting a brief overview of the cryogenics field and describing certain representative examples of the transfer of NASA-generated technology to the private sector, this presentation explores a singular relationship between NASA and another federal agency, the National Bureau of Standards. The relationship has operated both to generate and disseminate information fundamental to the broad growth of the cryogenics field.

Argonne National Laboratory technology transfer report, FY 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-11-01

In 1985 Argonne established the Technology Transfer Center (TTC). As of the end of FY 1987, the TTC has a staff equivalent to four full-time professionals, two secretaries, and two student aides; FY 1987 ORTA funding was $220K. A network of technology transfer representatives provides windows into and out of Argonne's technical divisions on technology transfer matters. The TTC works very closely with the ARCH Develoment Corporation, a not-for-profit corporation set up to commercialize selected Argonne and University of Chicago patents. The goal of the Technology Transfer Center at Argonne is to transfer technology developed at Argonne to the domesticmore » private sector by whatever means is most effective. The strategies by which this is accomplished are numerous and the TTC is, in effect, conducting a number of experiments to determine the most effective strategies. These include cooperative RandD agreements, work-for-others contracts, subcontracting to industry, formation of joint ventures via ARCH, residencies by industry staff at Argonne and vice versa, patent licensing and, of course, conferences, workshops and visits by industry and to industry.« less

Technology Transfer Program (TTP). Quality Assurance System. Volume 2. Appendices

DTIC Science & Technology

1980-03-03

LSCo Report No. - 2X23-5.1-4-I TECHNOLOGY TRANSFER PROGRAM (TTP) FINAL REPORT QUALITY ASSURANCE SYSTEM Appendix A Accuracy Control System QUALITY...4-1 TECHNOLOGY TRANSFER PROGRAM (TTP) FINAL REPORT QUALITY ASSURANCE SYSTEM Appendix A Accuracy Control System QUALITY ASSURANCE VOLUME 2 APPENDICES...prepared by: Livingston Shipbuilding Company Orange, Texas March 3, 1980 APPENDIX A ACCURACY CONTROL SYSTEM . IIII MARINE TECHNOLOGY. INC. HP-121

Computers and terminals as an aid to international technology transfer

NASA Technical Reports Server (NTRS)

Sweeney, W. T.

1974-01-01

As technology transfer becomes more popular and proves to be an economical method for companies of all sizes to take advantage of a tremendous amount of new and available technology from sources all over the world, the introduction of computers and terminals into the international technology transfer process is proving to be a successful method for companies to take part in this beneficial approach to new business opportunities.

Manufacturing process applications team (MATEAM). [technology transfer in the areas of machine tools and robots

NASA Technical Reports Server (NTRS)

1979-01-01

The transfer of NASA technology to the industrial sector is reported. Presentations to the machine tool and robot industries and direct technology transfers of the Adams Manipulator arm, a-c motor control, and the bolt tension monitor are discussed. A listing of proposed RTOP programs with strong potential is included. A detailed description of the rotor technology available to industry is given.

Data communications in a parallel active messaging interface of a parallel computer

DOEpatents

Archer, Charles J; Blocksome, Michael A; Ratterman, Joseph D; Smith, Brian E

2015-02-03

Data communications in a parallel active messaging interface (`PAMI`) of a parallel computer, the PAMI composed of data communications endpoints, each endpoint including a specification of data communications parameters for a thread of execution on a compute node, including specifications of a client, a context, and a task, endpoints coupled for data communications through the PAMI and through data communications resources, including receiving in an origin endpoint of the PAMI a SEND instruction, the SEND instruction specifying a transmission of transfer data from the origin endpoint to a first target endpoint; transmitting from the origin endpoint to the first target endpoint a Request-To-Send (`RTS`) message advising the first target endpoint of the location and size of the transfer data; assigning by the first target endpoint to each of a plurality of target endpoints separate portions of the transfer data; and receiving by the plurality of target endpoints the transfer data.

Data communications in a parallel active messaging interface of a parallel computer

DOEpatents

Archer, Charles J; Blocksome, Michael A; Ratterman, Joseph D; Smith, Brian E

2014-11-18

Data communications in a parallel active messaging interface (`PAMI`) of a parallel computer, the PAMI composed of data communications endpoints, each endpoint including a specification of data communications parameters for a thread of execution on a compute node, including specifications of a client, a context, and a task, endpoints coupled for data communications through the PAMI and through data communications resources, including receiving in an origin endpoint of the PAMI a SEND instruction, the SEND instruction specifying a transmission of transfer data from the origin endpoint to a first target endpoint; transmitting from the origin endpoint to the first target endpoint a Request-To-Send (`RTS`) message advising the first target endpoint of the location and size of the transfer data; assigning by the first target endpoint to each of a plurality of target endpoints separate portions of the transfer data; and receiving by the plurality of target endpoints the transfer data.

NASA's southeast technology transfer alliance: A cooperative technology assistance initiative

NASA Astrophysics Data System (ADS)

Craft, Harry G.; Sheehan, William; Johnson, Anne

1996-03-01

Since 1958, NASA has been charged with actively assisting in the transfer of technologies derived from the United States space program into the industrial sector of the U.S. economy. This has historically been accomplished through technology transfer offices working independently at each NASA field center. NASA recently restructured the program to provide regional coordination, maximize efficiencies, eliminate redundancies, and capitalize on each center's fundamental technology strengths. The nation is divided into six NASA technology transfer geographical regions with each region containing one or more NASA field centers and a regional technology transfer center. The southeast region includes the states of Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, and Tennessee. The NASA field centers in this region are: the Marshall Space Flight Center in Huntsville, Alabama; the Kennedy Space Center in Florida; and the Stennis Space Center in Bay St. Louis, Mississippi. The centers have teamed to focus primarily on regional industries and businesses, to provide a wide range of resources for U.S. industries, including access to unique government facilities, regional workshops, and technical problem solving. Hundreds of American businesses have benefited from this new regional initiative, as evidenced by reports of over 10,500 added or saved jobs and over 988 million worth of economic impacts as a result of their technology transfer activities.

Lessons learned during the development and transfer of technology related to a new Hib conjugate vaccine to emerging vaccine manufacturers.

PubMed

Hamidi, A; Boog, C; Jadhav, S; Kreeftenberg, H

2014-07-16

The incidence of Haemophilus Influenzae type b (Hib) disease in developed countries has decreased since the introduction of Hib conjugate vaccines in their National Immunization Programs (NIP). In countries where Hib vaccination is not applied routinely, due to limited availability and high cost of the vaccines, invasive Hib disease is still a cause of mortality. Through the development of a production process for a Hib conjugate vaccine and related quality control tests and the transfer of this technology to emerging vaccine manufacturers in developing countries, a substantial contribution was made to the availability and affordability of Hib conjugate vaccines in these countries. Technology transfer is considered to be one of the fastest ways to get access to the technology needed for the production of vaccines. The first Hib conjugate vaccine based on the transferred technology was licensed in 2007, since then more Hib vaccines based on this technology were licensed. This paper describes the successful development and transfer of Hib conjugate vaccine technology to vaccine manufacturers in India, China and Indonesia. By describing the lessons learned in this process, it is hoped that other technology transfer projects can benefit from the knowledge and experience gained. Copyright © 2014 Elsevier Ltd. All rights reserved.

Intracellular, genetic or congenital immunisation--transgenic approaches to increase disease resistance of farm animals.

PubMed

Müller, M; Brem, G

1996-01-26

Novel approaches to modify disease resistance or susceptibility in livestock are justified not only by economical reasons and with respect to animal welfare but also by recent advancements in molecular genetics. The control or elimination of infectious pathogens in farm animals is historically achieved by the use of vaccines and drugs and by quarantine safeguards and eradication. Currently, research on the improvement of disease resistance based on nucleic acid technology focuses on two main issues: additive gene transfer and the development of nucleic acid vaccines. The strategies aim at the stable or transient expression of components known to influence non-specific or specific host defence mechanisms against infectious pathogens. Thus, candidates for gene transfer experiments include all genes inducing or conferring innate and acquired immunity as well as specific disease resistance genes. Referring to the site and mode of action and the source of the effective agent the strategies are termed 'intracellular', 'genetic' and 'congenital' immunisation. The targeted disruption (deletive gene transfer) of disease susceptibility genes awaits the establishment of totipotential embryonic cell lineages in farm animals. The cytokine network regulates cellular viability, growth and differentiation in physiological and pathophysiological states. The identification of the JAK-STAT pathway used by many cytokines for their intracellular signal propagation has provided not only new target molecules for modulating the immune response but will also permit the further elucidation of host-pathogen interactions and resistance mechanisms.

International Agreement on Planetary Protection

NASA Technical Reports Server (NTRS)

2000-01-01

The maintenance of a NASA policy, is consistent with international agreements. The planetary protection policy management in OSS, with Field Center support. The advice from internal and external advisory groups (NRC, NAC/Planetary Protection Task Force). The technology research and standards development in bioload characterization. The technology research and development in bioload reduction/sterilization. This presentation focuses on: forward contamination - research on the potential for Earth life to exist on other bodies, improved strategies for planetary navigation and collision avoidance, and improved procedures for sterile spacecraft assembly, cleaning and/or sterilization; and backward contamination - development of sample transfer and container sealing technologies for Earth return, improvement in sample return landing target assessment and navigation strategy, planning for sample hazard determination requirements and procedures, safety certification, (liaison to NEO Program Office for compositional data on small bodies), facility planning for sample recovery system, quarantine, and long-term curation of 4 returned samples.

Adaptation and adaptation transfer characteristics of five different saccade types in the monkey

PubMed Central

Fuchs, Albert F.; Soetedjo, Robijanto

2015-01-01

Shifts in the direction of gaze are accomplished by different kinds of saccades, which are elicited under different circumstances. Saccade types include targeting saccades to simple jumping targets, delayed saccades to visible targets after a waiting period, memory-guided (MG) saccades to remembered target locations, scanning saccades to stationary target arrays, and express saccades after very short latencies. Studies of human cases and neurophysiological experiments in monkeys suggest that separate pathways, which converge on a common locus that provides the motor command, generate these different types of saccade. When behavioral manipulations in humans cause targeting saccades to have persistent dysmetrias as might occur naturally from growth, aging, and injury, they gradually adapt to reduce the dysmetria. Although results differ slightly between laboratories, this adaptation generalizes or transfers to all the other saccade types mentioned above. Also, when one of the other types of saccade undergoes adaptation, it often transfers to another saccade type. Similar adaptation and transfer experiments, which allow inferences to be drawn about the site(s) of adaptation for different saccade types, have yet to be done in monkeys. Here we show that simian targeting and MG saccades adapt more than express, scanning, and delayed saccades. Adaptation of targeting saccades transfers to all the other saccade types. However, the adaptation of MG saccades transfers only to delayed saccades. These data suggest that adaptation of simian targeting saccades occurs on the pathway common to all saccade types. In contrast, only the delayed saccade command passes through the adaptation site of the MG saccade. PMID:25855693

Manufacturing process applications team (MATeam)

NASA Technical Reports Server (NTRS)

Bangs, E. R.; Meyer, J. D.

1978-01-01

Activities of the manufacturing applications team (MATeam) in effecting widespread transfer of NASA technology to aid in the solution of manufacturing problems in the industrial sector are described. During the program's first year of operation, 450 companies, industry associations, and government agencies were contacted, 150 manufacturing problems were documented, and 20 potential technology transfers were identified. Although none of the technology transfers has been commercialized and put in use, several are in the applications engineering phase, and others are in the early stages of implementation. The technology transfer process is described and guidelines used for the preparation of problems statements are included.

Social issues and implications of remote sensing applications: Paradigms of technology transfer

NASA Technical Reports Server (NTRS)

Hoos, I. R.

1980-01-01

The transfer of technology from one federal agency to another was observed in the case of the move of LANDSAT to NOAA. An array of unanticipated consequences was found that have important impacts on both the process and outcome of the transfer. When the process was studied from viewpoint of the ultimate recipient, a set of expectations and perceptions were found that figure more in a final assessment than do the attributes of the technology being transfered. The question of how to link a technology with a community of potential users was studed in detail.

Molecular profiling of childhood cancer: Biomarkers and novel therapies.

PubMed

Saletta, Federica; Wadham, Carol; Ziegler, David S; Marshall, Glenn M; Haber, Michelle; McCowage, Geoffrey; Norris, Murray D; Byrne, Jennifer A

2014-06-01

Technological advances including high-throughput sequencing have identified numerous tumor-specific genetic changes in pediatric and adolescent cancers that can be exploited as targets for novel therapies. This review provides a detailed overview of recent advances in the application of target-specific therapies for childhood cancers, either as single agents or in combination with other therapies. The review summarizes preclinical evidence on which clinical trials are based, early phase clinical trial results, and the incorporation of predictive biomarkers into clinical practice, according to cancer type. There is growing evidence that molecularly targeted therapies can valuably add to the arsenal available for treating childhood cancers, particularly when used in combination with other therapies. Nonetheless the introduction of molecularly targeted agents into practice remains challenging, due to the use of unselected populations in some clinical trials, inadequate methods to evaluate efficacy, and the need for improved preclinical models to both evaluate dosing and safety of combination therapies. The increasing recognition of the heterogeneity of molecular causes of cancer favors the continued development of molecularly targeted agents, and their transfer to pediatric and adolescent populations.

Study on portable optical 3D coordinate measuring system

NASA Astrophysics Data System (ADS)

Ren, Tongqun; Zhu, Jigui; Guo, Yinbiao

2009-05-01

A portable optical 3D coordinate measuring system based on digital Close Range Photogrammetry (CRP) technology and binocular stereo vision theory is researched. Three ultra-red LED with high stability is set on a hand-hold target to provide measuring feature and establish target coordinate system. Ray intersection based field directional calibrating is done for the intersectant binocular measurement system composed of two cameras by a reference ruler. The hand-hold target controlled by Bluetooth wireless communication is free moved to implement contact measurement. The position of ceramic contact ball is pre-calibrated accurately. The coordinates of target feature points are obtained by binocular stereo vision model from the stereo images pair taken by cameras. Combining radius compensation for contact ball and residual error correction, object point can be resolved by transfer of axes using target coordinate system as intermediary. This system is suitable for on-field large-scale measurement because of its excellent portability, high precision, wide measuring volume, great adaptability and satisfying automatization. It is tested that the measuring precision is near to +/-0.1mm/m.

Influenza vaccine production for Brazil: a classic example of successful North-South bilateral technology transfer.

PubMed

Miyaki, Cosue; Meros, Mauricio; Precioso, Alexander R; Raw, Isaias

2011-07-01

Technology transfer is a promising approach to increase vaccine production at an affordable price in developing countries. In the case of influenza, it is imperative that developing countries acquire the technology to produce pandemic vaccines through the transfer of know-how, as this will be the only way for the majority of these countries to face the huge demand for vaccine created by influenza pandemics. Access to domestically produced influenza vaccine in such health crises is thus an important national defence strategy. However, technology transfer is not a simple undertaking. It requires a committed provider who is willing to transfer a complete production process, and not just the formulation and fill-finish parts of the process. It requires a recipient with established experience in vaccine production for human use and the ability to conduct research into new developments. In addition, the country of the recipient should preferably have sufficient financial resources to support the undertaking, and an internal market for the new vaccine. Technology transfer should create a solid partnership that results in the joint development of new competency, improvements to the product, and to further innovation. The Instituto Butantan-sanofi pasteur partnership can be seen as a model for successful technology transfer and has led to the technological independence of the Instituto Butantan in the use a strategic public health tool. Copyright © 2011 Elsevier Ltd. All rights reserved.

WLCG Transfers Dashboard: a Unified Monitoring Tool for Heterogeneous Data Transfers

NASA Astrophysics Data System (ADS)

Andreeva, J.; Beche, A.; Belov, S.; Kadochnikov, I.; Saiz, P.; Tuckett, D.

2014-06-01

The Worldwide LHC Computing Grid provides resources for the four main virtual organizations. Along with data processing, data distribution is the key computing activity on the WLCG infrastructure. The scale of this activity is very large, the ATLAS virtual organization (VO) alone generates and distributes more than 40 PB of data in 100 million files per year. Another challenge is the heterogeneity of data transfer technologies. Currently there are two main alternatives for data transfers on the WLCG: File Transfer Service and XRootD protocol. Each LHC VO has its own monitoring system which is limited to the scope of that particular VO. There is a need for a global system which would provide a complete cross-VO and cross-technology picture of all WLCG data transfers. We present a unified monitoring tool - WLCG Transfers Dashboard - where all the VOs and technologies coexist and are monitored together. The scale of the activity and the heterogeneity of the system raise a number of technical challenges. Each technology comes with its own monitoring specificities and some of the VOs use several of these technologies. This paper describes the implementation of the system with particular focus on the design principles applied to ensure the necessary scalability and performance, and to easily integrate any new technology providing additional functionality which might be specific to that technology.

Applications of aerospace technology in biology and medicine

NASA Technical Reports Server (NTRS)

Beall, H. C.; Brown, J. N.; Rouse, D. J.; Ruddle, J. C.; Scearce, R. W.

1978-01-01

A bipolar, donor-recipient model of medical technology transfer is introduced to provide a basis for the team's methodology. That methodology is designed (1) to identify medical problems and NASA technology that in combination constitute opportunities for successful medical products, (2) to obtain the early participation of industry in the transfer proces, and (3) to obtain acceptance by the medical community of new medical products based on NASA technology. Two commercial technology transfers and five institutional technology transfers were completed in 1977. A new, commercially available teaching manikin system uses NASA-developed concepts and techniques for effective visual presentation of information and data. Drugs shipped by the National Cancer Institute to locations throughout the world are maintained at low temperatures in shipping containers that incorporate recommendations made by NASA.

Technology Transfer and the Civil Space Program. Volume 2: Workshop proceedings

NASA Technical Reports Server (NTRS)

1992-01-01

The objectives were to (1) provide a top-level review of the Integrated Technology Plan (ITP) and current civil space technology plans, including planning processes and technologies; (2) discuss and assess technology transfer (TT) experiences across a wide range of participants; (3) identify alternate categories/strategies for TT and define the objectives of transfer processes in each case; (4) identify the roles of various government 'stakeholders', aerospace industry, industries at large, and universities in civil space technology research, development, demonstration, and transfer; (5) identify potential barriers and/or opportunities to successful civil space TT; (6) identify specific needs for innovations in policy, programs, and/or procedures to facilitate TT; and (7) develop a plan of attack for the development of a workshop report. Papers from the workshop are presented.

Nominal and functional task difficulty in skill acquisition: Effects on performance in two tests of transfer.

PubMed

Sanli, Elizabeth A; Lee, Timothy D

2015-06-01

The influence of nominal and functional task difficulty during the acquisition of a motor skill was examined in two tests of transfer of learning. The task involved a ballistic, target-directed, finger action. Nominal task difficulty was defined as the distance of the target from the home position. Functional task difficulty was created by manipulating the progression of target distances during practice. Based on the challenge point framework (Guadagnoli & Lee, 2004), we predicted that practice with a set of targets farther away from the performer would benefit from less functional task difficulty, while practice with a closer set of targets would benefit from more functional task difficulty. In single-task transfer tests, learners who practiced using the high nominal task difficulty targets benefitted in terms of persistence of performance over time. In dual-task transfer tests, groups with an intermediate combined (nominal and functional) task difficulty performed with greater persistence over time on tests of transfer than those who practiced with the highest or lowest combined difficulty. Together these findings suggest that the influences of nominal and functional task difficulty during acquisition are weighted differentially depending upon the transfer test context. The challenge point framework does not accurately capture this complex relationship in its current form. Copyright © 2015 Elsevier B.V. All rights reserved.

Diagnostic Marker for Improving Treatment Outcomes of Hepatitis C | NCI Technology Transfer Center | TTC

Cancer.gov

NCI Researchers have discovered Interferon-lambda 4 (IFNL4), a protein found through analysis of genomic data. Preliminary studies indicate that this protein may play a role in the clearance of HCV and may be a new target for diagnosing and treating HCV infection. The National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics (DCEG) Immunoepidemiology Branch is seeking statements of capability or interest from parties interested in in-licensing or collaborative research to further co-develop a gene-based diagnostic for Hepatitis C virus (HepC, HCV).

75 FR 42030 - Amendments to National Emission Standards for Hazardous Air Pollutants: Area Source Standards for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

.... National Technology Transfer Advancement Act J. Executive Order 12898: Federal Actions to Address..., or use of energy. I. National Technology Transfer and Advancement Act Section 12(d) of the National Technology Transfer and Advancement Act of 1995 (``NTTAA''), Public Law 104-113 (15 U.S.C. 272 note) directs...

76 FR 35806 - Amendments to National Emission Standards for Hazardous Air Pollutants for Area Sources: Plating...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

..., or Use I. National Technology Transfer Advancement Act J. Executive Order 12898: Federal Actions To... action under Executive Order 12866. I. National Technology Transfer Advancement Act Section 12(d) of the National Technology Transfer and Advancement Act (NTTAA) of 1995 (Pub. L. 104-113, section 12(d), 15 U.S.C...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2013 CFR

2013-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2013-04-01 2013-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2010 CFR

2010-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2010-04-01 2010-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2014 CFR

2014-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2014-04-01 2014-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2012 CFR

2012-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2012-04-01 2012-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2011 CFR

2011-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2011-04-01 2011-04-01 false What are the requirements for research, development, and...

Measuring the Impact of University Technology Transfer: A Guide to Methodologies, Data Needs, and Sources

ERIC Educational Resources Information Center

Lowe, Robert A.; Quick, Suzanne K.

2005-01-01

This paper discusses measures that capture the impact of university technology transfer activities on a university?s local and regional economies (economic impact). Such assessments are of increasing interest to policy makers, researchers and technology transfer professionals, yet there have been few published discussions of the merits of various…

Technology Transfer as an Entrepreneurial Practice in Higher Education. CELCEE Digest No. 98-9.

ERIC Educational Resources Information Center

Faris, Shannon K.

This digest examines some of the literature on technology transfer in the context of higher education, noting that the practice of capitalizing on academic research for commercial purposes has the potential to generate financial resources for the participating institutions of higher education. Several examples of technology transfer are cited,…

Academic Technology Transfer: Tracking, Measuring and Enhancing Its Impact

ERIC Educational Resources Information Center

Fraser, John

2010-01-01

Since the 1980 passage of the US Bayh-Dole Act, academic technology transfer has gained profile globally as a key component of knowledge-driven economic development. Research universities are seen as key contributors. In this article, focusing on the USA and drawing on over twenty years of experience in the field of academic technology transfer in…

A New Technology Transfer Paradigm: How State Universities Can Collaborate with Industry in the USA

ERIC Educational Resources Information Center

Renault, Catherine S.; Cope, Jeff; Dix, Molly; Hersey, Karen

2008-01-01

In some US states, policy makers, pressed by local and regional industrial interests, are debating how to "reform" technology transfer at public universities. "Reform" in this context is generally understood to mean redirecting university technology transfer activities to increase the benefits of state-funded research to local industries.…

Report of a Planning Conference for Solar Technology Information Transfer. Austin, Texas, 12-13 June 1979).

ERIC Educational Resources Information Center

Southwestern Library Association, Stillwater, OK.

Charged with the responsibility of determining the best way to plan for solar technology information transfer within the state of Texas, participants in the Planning Conference for Solar Technology Information Transfer met to discuss the many ongoing activities related to energy information dissemination, to analyze the resources available in…

Summary of the National Technology Transfer and Advancement Act

EPA Pesticide Factsheets

Provides a summary of the National Technology Transfer and Advancement Act which pomote economic, environmental, and social well-being by bringing technology and industrial innovation to the marketplace

License Agreements | NCI Technology Transfer Center | TTC

Cancer.gov

NCI Technology Transfer Center (TTC) licenses the discoveries of NCI and nine other NIH Institutes so new technologies can be developed and commercialized, to convert them into public health benefits.

Technology transfer and Rockwell International

NASA Technical Reports Server (NTRS)

Gernand, Joseph

1992-01-01

Two technology partnership models are presented for consideration. The first model posits a government buyer of technology, and the second model posits that the customer is the consumer of the technology. These two models are concerned with methods of and impediments to technology transfer and information dissemination in government/contractor relationships.

Sandia National Laboratories: Working with Sandia

Science.gov Websites

Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios Report Economic Impact Environmental Reports Fact Sheets Search Sandia Publications Labs Accomplishments /Technology Transfer Technology Partnerships Economic Impact Facebook Twitter YouTube Flickr RSS Working with

Sandia National Laboratories: News: Economic Impact

Science.gov Websites

Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios Report Economic Impact Environmental Reports Fact Sheets Search Sandia Publications Labs Accomplishments /Technology Transfer Technology Partnerships Economic Impact Facebook Twitter YouTube Flickr RSS Working with

SITE TECHNOLOGY CAPSULE: BIOGENESIS SOIL WASHING TECHNOLOGY

EPA Science Inventory

Soil washing technologies are designed to transfer contaminants from soil to a liquid phase. The BloGenesis™ soil washing technology uses a proprietary surfactant solution to transfer organic contaminants from soil to wastewater. The surfactant used in the soil washing process wa...

Transferring Technology to Industry

NASA Technical Reports Server (NTRS)

Wolfenbarger, J. Ken

2006-01-01

This slide presentation reviews the technology transfer processes in which JPL has been involved to assist in transferring the technology derived from aerospace research and development to industry. California Institute of Technology (CalTech), the organization that runs JPL, is the leading institute in patents for all U.S. universities. There are several mechanisms that are available to JPL to inform industry of these technological advances: (1) a dedicated organization at JPL, National Space Technology Applications (NSTA), (2) Tech Brief Magazine, (3) Spinoff magazine, and (4) JPL publications. There have also been many start-up organizations and businesses from CalTech.

Developing strategies for detection of gene doping.

PubMed

Baoutina, Anna; Alexander, Ian E; Rasko, John E J; Emslie, Kerry R

2008-01-01

It is feared that the use of gene transfer technology to enhance athletic performance, the practice that has received the term 'gene doping', may soon become a real threat to the world of sport. As recognised by the anti-doping community, gene doping, like doping in any form, undermines principles of fair play in sport and most importantly, involves major health risks to athletes who partake in gene doping. One attraction of gene doping for such athletes and their entourage lies in the apparent difficulty of detecting its use. Since the realisation of the threat of gene doping to sport in 2001, the anti-doping community and scientists from different disciplines concerned with potential misuse of gene therapy technologies for performance enhancement have focused extensive efforts on developing robust methods for gene doping detection which could be used by the World Anti-Doping Agency to monitor athletes and would meet the requirements of a legally defensible test. Here we review the approaches and technologies which are being evaluated for the detection of gene doping, as well as for monitoring the efficacy of legitimate gene therapy, in relation to the detection target, the type of sample required for analysis and detection methods. We examine the accumulated knowledge on responses of the body, at both cellular and systemic levels, to gene transfer and evaluate strategies for gene doping detection based on current knowledge of gene technology, immunology, transcriptomics, proteomics, biochemistry and physiology. (c) 2008 John Wiley & Sons, Ltd.

Rational engineering of Geobacter sulfurreducens electron transfer components: A foundation for building improved Geobacter-based bioelectrochemical technologies

DOE PAGES

Dantas, Joana M.; Morgado, Leonor; Aklujkar, Muktak; ...

2015-07-30

Multiheme cytochromes have been implicated in Geobacter sulfurreducens extracellular electron transfer (EET). These proteins are potential targets to improve EET and enhance bioremediation and electrical current production by G. sulfurreducens. However, the functional characterization of multiheme cytochromes is particularly complex due to the co-existence of several microstates in solution, connecting the fully reduced and fully oxidized states. Throughout the last decade, new strategies have been developed to characterize multiheme redox proteins functionally and structurally. These strategies were used to reveal the functional mechanism of G. sulfurreducens multiheme cytochromes and also to identify key residues in these proteins for EET. Inmore » previous studies, we set the foundations for enhancement of the EET abilities of G. sulfurreducens by characterizing a family of five triheme cytochromes (PpcA-E). These periplasmic cytochromes are implicated in electron transfer between the oxidative reactions of metabolism in the cytoplasm and the reduction of extracellular terminal electron acceptors at the cell's outer surface. The results obtained suggested that PpcA can couple e -/H + transfer, a property that might contribute to the proton electrochemical gradient across the cytoplasmic membrane for metabolic energy production. The structural and functional properties of PpcA were characterized in detail and used for rational design of a family of 23 single site PpcA mutants. In this review, we summarize the functional characterization of the native and mutant proteins. Mutants that retain the mechanistic features of PpcA and adopt preferential e -/H + transfer pathways at lower reduction potential values compared to the wild-type protein were selected for in vivo studies as the best candidates to increase the electron transfer rate of G. sulfurreducens. For the first time G. sulfurreducens strains have been manipulated by the introduction of mutant forms of essential proteins with the aim to develop and improve bioelectrochemical technologies.« less

SMART-1: key technologies and autonomy implementations

NASA Astrophysics Data System (ADS)

Elfving, A.; Stagnaro, L.; Winton, A.

2003-01-01

SMART-1 is the first of the Small Missions for Advanced Research in Technology of the ESA Horizons 2000 Science Plan. The main mission objective of SMART-1 is to demonstrate innovative and key technologies for scientific deep-space missions. One of the key technologies is the solar electric propulsion used as primary propulsion. The electric propulsion will be using 1400 W to transfer the 350 kg spacecraft from an Ariane 5 standard GTO to an elliptic Moon polar orbit, 10000×300 km. The total mission time is 24 months including a maximum of 18 months transfer time. The spacecraft development entered the detailed design and implementation phase in October 1999, under the responsibility of the Swedish Space Cooperation as prime contractor, and the flight acceptance is targeted for the 3rd quarter of 2002. The committed total life cost budget is 84 million Euro. Apart from the in-orbit demonstration of electric propulsion as primary propulsion, SMART-1 is implementing many other enabling technologies for deep-space missions such as deep-space transponder with communication in X-band for uplink and in X- and Ka-band for downlink, highly integrated and radiation tolerant microprocessors, FPGAs and memories, high on-board autonomy driven by ground communication only once per 4 days, maximum available power to electric propulsion by centralised and software-controlled power management, minimum propellant consumption through innovative angular momentum management. In addition, the spacecraft avionics design is tailored to the low-cost philosophy by enabling flexible integration of commercial off the shelf (COTS) equipment. The scientific instruments, five in total, support characterisation of the electric propulsion thrust environment during the long transfer phase and detailed imaging and spectroscopy of the lunar surface in visible, infrared and X-ray during the Moon orbiting phase. Several of the instruments implement new enabling technologies, e.g. swept charge devices for the X-ray spectrometer and quarts gratings for the near-infrared reflectance spectrometer. The paper summarises the baseline mission design, the projected scientific and technology output, and describe the spacecraft bus design. The main part of the paper highlights and elaborate on a number of spacecraft bus technologies; the on-board autonomy, the avionics design, and the X/Ka-band transponder.

Transfer of technology for production of rabies vaccine: Memorandum from a WHO Meeting*

PubMed Central

1985-01-01

The important challenge of prevention and control of rabies in the world will require international efforts to increase the availability and use of high quality cell-culture rabies vaccines for use in man and animals. An important aspect of activities to ensure such availability is transfer of technologies to developing countries for production of these vaccines. This article, which is based on the report of a WHO Consultation, outlines the technical options for vaccine production. The principles and economic aspects of technology transfer are considered, and a WHO assistance programme is outlined. It is concluded that technology transfer should be mediated through a framework of national institutes, expert panels, WHO collaborating centres, production and control laboratories, and other relevant institutions. On this basis, recommendations are made concerning the mechanisms of technology transfer for production of cell-culture rabies vaccines. PMID:3878738

Transferring experience labs for production engineering students to universities in newly industrialized countries

NASA Astrophysics Data System (ADS)

Leiden, A.; Posselt, G.; Bhakar, V.; Singh, R.; Sangwan, K. S.; Herrmann, C.

2018-01-01

The Indian economy is one of the fastest growing economies in the world and the demand for the skilled engineers is increasing. Subsequently the Indian education sector is growing to provide the necessary number of skilled engineers. Current Indian engineering graduates have broad theoretical background but lack in methodological, soft and practical skills. To bridge this gap, the experience lab ideas from the engineering education at “Die Lernfabrik” (learning factory) of the Technische Universität Braunschweig (TU Braunschweig) is transferred to the Birla Institute of Technology and Science in Pilani (BITS Pilani), India. This Lernfabrik successfully strengthened the methodological, soft and practical skills of the TU Braunschweig production-engineering graduates. The target group is discrete manufacturing education with focusing on energy and resource efficiency as well as cyber physical production systems. As the requirements of industry and academia in India differs from Germany, the transfer of the experience lab to the Indian education system needs special attention to realize a successful transfer project. This publication provides a unique approach to systematically transfer the educational concept in Learning Factory from a specific university environment to a different environment in a newly industrialized country. The help of a bilateral university driven practice partnership between the two universities creates a lighthouse for the Indian university environment.

Exploring the limits of optical microscopy: live cell and superresolution fluorescence microscopy of HIV-1 Transfer Between T lymphocytes Across the Virological Synapse

NASA Astrophysics Data System (ADS)

McNerney, Gregory Paul

Human immunodeficiency virus 1 (HIV-1) is a human retrovirus that efficiently, albeit gradually, overruns the immune system. An already infected T lymphocyte can latch onto another T lymphocyte whereby creating a virological synapse (VS); this junction drives viral assembly and transfer to the target cell in batches in an efficient, protective manor. My Ph.D. doctoral thesis focused on studying this transmission mechanism using advanced optical imaging modalities and the fully infectious fluorescent clone HIV Gag-iGFP. T lymphocytes are non-adherent cells (˜10 um thick) and the viral transmission process is fairly dynamic, hence we employed a custom spinning disk confocal microscope that revealed many interesting characteristics of this cooperative event. This methodology has low throughput as cell contact and transfer is at random. Optical tweezers was then added to the microscope to directly initiate cell contact at will. To assess when viral maturation occurs post-transfer, an optical assay based off of Forster resonance energy transfer was developed to monitor maturation. Structured illumination microscopy was further used to image the process at higher resolution and it showed that viral particles are not entering existing degradative compartments. Non-HIV-1 applications of the optical technologies are also reviewed.

Rural hospital information technology implementation for safety and quality improvement: lessons learned.

PubMed

Tietze, Mari F; Williams, Josie; Galimbertti, Marisa

2009-01-01

This grant involved a hospital collaborative for excellence using information technology over 3-year period. The project activities focused on the improvement of patient care safety and quality in Southern rural and small community hospitals through the use of technology and education. The technology component of the design involved the implementation of a Web-based business analytic tool that allows hospitals to view data, create reports, and analyze their safety and quality data. Through a preimplementation and postimplementation comparative design, the focus of the implementation team was twofold: to recruit participant hospitals and to implement the technology at each of the 66 hospital sites. Rural hospitals were defined as acute care hospitals located in a county with a population of less than 100 000 or a state-administered Critical Access Hospital, making the total study population target 188 hospitals. Lessons learned during the information technology implementation of these hospitals are reflective of the unique culture, financial characteristics, organizational structure, and technology architecture of rural hospitals. Specific steps such as recruitment, information technology assessment, conference calls for project planning, data file extraction and transfer, technology training, use of e-mail, use of telephones, personnel management, and engaging information technology vendors were found to vary greatly among hospitals.

Affordable Launch Services using the Sport Orbit Transfer System

NASA Astrophysics Data System (ADS)

Goldstein, D. J.

2002-01-01

Despite many advances in small satellite technology, a low-cost, reliable method is needed to place spacecraft in their de- sired orbits. AeroAstro has developed the Small Payload ORbit Transfer (SPORTTM) system to provide a flexible low-cost orbit transfer capability, enabling small payloads to use low-cost secondary launch opportunities and still reach their desired final orbits. This capability allows small payloads to effectively use a wider variety of launch opportunities, including nu- merous under-utilized GTO slots. Its use, in conjunction with growing opportunities for secondary launches, enable in- creased access to space using proven technologies and highly reliable launch vehicles such as the Ariane family and the Starsem launcher. SPORT uses a suite of innovative technologies that are packaged in a simple, reliable, modular system. The command, control and data handling of SPORT is provided by the AeroAstro BitsyTM core electronics module. The Bitsy module also provides power regulation for the batteries and optional solar arrays. The primary orbital maneuvering capability is provided by a nitrous oxide monopropellant propulsion system. This system exploits the unique features of nitrous oxide, which in- clude self-pressurization, good performance, and safe handling, to provide a light-weight, low-cost and reliable propulsion capability. When transferring from a higher energy orbit to a lower energy orbit (i.e. GTO to LEO), SPORT uses aerobraking technol- ogy. After using the propulsion system to lower the orbit perigee, the aerobrake gradually slows SPORT via atmospheric drag. After the orbit apogee is reduced to the target level, an apogee burn raises the perigee and ends the aerobraking. At the conclusion of the orbit transfer maneuver, either the aerobrake or SPORT can be shed, as desired by the payload. SPORT uses a simple design for high reliability and a modular architecture for maximum mission flexibility. This paper will discuss the launch system and its application to small satellite launch without increasing risk. It will also discuss relevant issues such as aerobraking operations and radiation issues, as well as existing partnerships and patents for the system.

Sandia National Laboratories: Working with Sandia: Current Suppliers

Science.gov Websites

Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios Report Economic Impact Environmental Reports Fact Sheets Search Sandia Publications Labs Accomplishments /Technology Transfer Technology Partnerships Economic Impact Facebook Twitter YouTube Flickr RSS Top Current

Sandia National Laboratories: Working with Sandia: Prospective Suppliers

Science.gov Websites

Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios Report Economic Impact Environmental Reports Fact Sheets Search Sandia Publications Labs Accomplishments /Technology Transfer Technology Partnerships Economic Impact Facebook Twitter YouTube Flickr RSS Working with

Technology Transfer Center to Assume Patenting and Licensing Responsibilities | Poster

Cancer.gov

The NCI Technology Transfer Center (TTC) is undergoing a reorganization that will bring patenting and licensing responsibilities to the Shady Grove and Frederick offices by October 2015. The reorganization is a result of an effort begun in 2014 by NIH to improve the organizational structure of technology transfer at NIH to meet the rapid rate of change within science, technology, and industry, and to better align the science and laboratory goals with the licensing and patenting process.

[Nasal submicron emulsion of Scutellariae Radix extract preparation technology research based on phase transfer of solute technology].

PubMed

Shi, Ya-jun; Shi, Jun-hui; Chen, Shi-bin; Yang, Ming

2015-07-01

Based on the demand of nasal drug delivery high drug loadings, using the unique phase transfer of solute, integrating the phospholipid complex preparation and submicron emulsion molding process of Scutellariae Radix extract, the study obtained the preparation of the high drug loadings submicron emulsion of Scutellariae Radix extract. In the study of drug solution dispersion method, the uniformity of drug dispersed as the evaluation index, the traditional mixing method, grinding, homogenate and solute phase transfer technology were investigated, and the solute phase transfer technology was adopted in the last. With the adoption of new technology, the drug loading capacity reached 1.33% (phospholipid complex was 4%). The drug loading capacity was improved significantly. The transfer of solute method and timing were studied as follows,join the oil phase when the volume of phospholipid complex anhydrous ethanol solution remaining 30%, the solute phase transfer was completed with the continued recycling of anhydrous ethanol. After drug dissolved away to oil phase, the preparation technology of colostrum was determined with the evaluation index of emulsion droplet form. The particle size of submicron emulsion, PDI and stability parameters were used as evaluation index, orthogonal methodology were adopted to optimize the submicron emulsion ingredient and main influential factors of high pressure homogenization technology. The optimized preparation technology of Scutellariae Radix extract nasal submicron emulsion is practical and stable.

Technology transfer for women entrepreneurs: issues for consideration.

PubMed

Everts, S I

1998-01-01

This article discusses the effectiveness of technology transfers to women entrepreneurs in developing countries. Most women's enterprises share common characteristics: very small businesses, employment of women owners and maybe some family members, limited working capital, low profit margins, and flexible or part-time work. Many enterprises do not plan for growth. Women tend to diversify and use risk-avoidance strategies. Support for women's enterprises ignores the characteristics of women's enterprises. Support mechanisms could be offered that would perfect risk-spreading strategies and dynamic enterprise management through other means than growth. Many initiatives, since the 1970s, have transferred technologies to women. Technologies were applied to only a few domains and were viewed as appropriate based on their small size, low level of complexity, low cost, and environmental friendliness. Technology transfers may not be viewed by beneficiaries as the appropriate answer to needs. The bottleneck in transfers to women is not in the development of prototypes, but in the dissemination of technology that is sustainable, appropriate, and accessible. Key features for determining appropriateness include baseline studies, consumer linkages, and a repetitive process. Institutional factors may limit appropriateness. There is a need for long-term outputs, better links with users, training in use of the technology, grouping of women into larger units, and technology availability in quantities large enough to meet demand. Guidelines need to be developed that include appropriate content and training that ensures transfer of knowledge to practice.

Surface patterning by pulsed-laser-induced transfer of metals and compounds

NASA Astrophysics Data System (ADS)

Toth, Zsolt; Mogyorosi, Peter; Szoerenyi, Tamas

1990-08-01

Besults of a systematic study on Q-switched nthy laser induced rrrn2 area transfer of supported titanium and chranium thin films and Ge/Se multilayer structures are reported. The appearance of the prints is governed by film-support adhesion and source-target spacing. Best quality prints are produced by ablating well adhering ntal films in close proximity ( spacing < 15 pm) to the target to be patterned. Transfer fran stacked elenntaxy layers as a source offers a unique possibility of depositing acinpound films by mixing the constituents and transferring the material onto the target substrate in a single step.

Benchmark Report on Key Outage Attributes: An Analysis of Outage Improvement Opportunities and Priorities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Germain, Shawn St.; Farris, Ronald

2014-09-01

Advanced Outage Control Center (AOCC), is a multi-year pilot project targeted at Nuclear Power Plant (NPP) outage improvement. The purpose of this pilot project is to improve management of NPP outages through the development of an AOCC that is specifically designed to maximize the usefulness of communication and collaboration technologies for outage coordination and problem resolution activities. This report documents the results of a benchmarking effort to evaluate the transferability of technologies demonstrated at Idaho National Laboratory and the primary pilot project partner, Palo Verde Nuclear Generating Station. The initial assumption for this pilot project was that NPPs generally domore » not take advantage of advanced technology to support outage management activities. Several researchers involved in this pilot project have commercial NPP experience and believed that very little technology has been applied towards outage communication and collaboration. To verify that the technology options researched and demonstrated through this pilot project would in fact have broad application for the US commercial nuclear fleet, and to look for additional outage management best practices, LWRS program researchers visited several additional nuclear facilities.« less

76 FR 2860 - National Emission Standards for Hazardous Air Pollutants From the Portland Cement Manufacturing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-18

... action under Executive Order 12866. I. National Technology Transfer and Advancement Act Section 12(d) of the National Technology Transfer and Advancement Act of 1995 (``NTTAA''), Public Law 104-113 (15 U.S.C... of section 12(d) of the National Technology Transfer and Advancement Act of 1995 (15 U.S.C. 272) do...

Describing an Environment for a Self-Sustaining Technology Transfer Service in a Small Research Budget University: A Case Study

ERIC Educational Resources Information Center

Nieb, Sharon Lynn

2014-01-01

This single-site qualitative study sought to identify the characteristics that contribute to the self sustainability of technology transfer services at universities with small research budgets through a case study analysis of a small research budget university that has been operating a financially self-sustainable technology transfer service for…

Technology Transfer Center to Assume Patenting and Licensing Responsibilities | Poster

Cancer.gov

The NCI Technology Transfer Center (TTC) is undergoing a reorganization that will bring patenting and licensing responsibilities to the Shady Grove and Frederick offices by October 2015. The reorganization is a result of an effort begun in 2014 by NIH to improve the organizational structure of technology transfer at NIH to meet the rapid rate of change within science,

Technological inductive power transfer systems

NASA Astrophysics Data System (ADS)

Madzharov, Nikolay D.; Nemkov, Valentin S.

2017-05-01

Inductive power transfer is a very fast expanding technology with multiple design principles and practical implementations ranging from charging phones and computers to bionic systems, car chargers and continuous power transfer in technological lines. Only a group of devices working in near magnetic field is considered. This article is devoted to overview of different inductive power transfer (IPT) devices. The review of literature in this area showed that industrial IPT are not much discussed and examined. The authors have experience in design and implementation of several types of IPTs belonging to wireless automotive chargers and to industrial application group. Main attention in the article is paid to principles and design of technological IPTs

Reaching for the cloud: on the lessons learned from grid computing technology transfer process to the biomedical community.

PubMed

Mohammed, Yassene; Dickmann, Frank; Sax, Ulrich; von Voigt, Gabriele; Smith, Matthew; Rienhoff, Otto

2010-01-01

Natural scientists such as physicists pioneered the sharing of computing resources, which led to the creation of the Grid. The inter domain transfer process of this technology has hitherto been an intuitive process without in depth analysis. Some difficulties facing the life science community in this transfer can be understood using the Bozeman's "Effectiveness Model of Technology Transfer". Bozeman's and classical technology transfer approaches deal with technologies which have achieved certain stability. Grid and Cloud solutions are technologies, which are still in flux. We show how Grid computing creates new difficulties in the transfer process that are not considered in Bozeman's model. We show why the success of healthgrids should be measured by the qualified scientific human capital and the opportunities created, and not primarily by the market impact. We conclude with recommendations that can help improve the adoption of Grid and Cloud solutions into the biomedical community. These results give a more concise explanation of the difficulties many life science IT projects are facing in the late funding periods, and show leveraging steps that can help overcoming the "vale of tears".

Federal Technology Transfer Act (FTTA)

EPA Pesticide Factsheets

EPA's Federal Technology Transfer Act (FTTA) is a mechanism with which EPA can patent its inventions and license them to companies, through which innovative technologies can enter the marketplace to improve the environment and human health.

Fully-human Heavy-chain-only Anti-B-cell Maturation Antigen (BCMA) Chimeric Antigen Receptors (CARs) | NCI Technology Transfer Center | TTC

Cancer.gov

Chimeric Antigen Receptor T cell (CAR-T) therapies that specifically target B-cell maturation antigen (BCMA) are strong therapeutic candidates for patients with plasma cell malignancy diseases such as, multiple myeloma (MM), as well as for patients with Hodgkin’s lymphoma. BCMA is a cell surface protein preferentially expressed on a subset of B cells and mature plasma cells, but not on other cells in the body. The limited expression of BCMA on B and plasma cells makes BCMA an attractive therapeutic target for B cell and plasma cell malignancy diseases. The 12 anti-BCMA CARs described are fully human CARS and have the potential to treat patients with various plasma cell and B cell malignancy diseases.

Miniaturization of High-Throughput Epigenetic Methyltransferase Assays with Acoustic Liquid Handling.

PubMed

Edwards, Bonnie; Lesnick, John; Wang, Jing; Tang, Nga; Peters, Carl

2016-02-01

Epigenetics continues to emerge as an important target class for drug discovery and cancer research. As programs scale to evaluate many new targets related to epigenetic expression, new tools and techniques are required to enable efficient and reproducible high-throughput epigenetic screening. Assay miniaturization increases screening throughput and reduces operating costs. Echo liquid handlers can transfer compounds, samples, reagents, and beads in submicroliter volumes to high-density assay formats using only acoustic energy-no contact or tips required. This eliminates tip costs and reduces the risk of reagent carryover. In this study, we demonstrate the miniaturization of a methyltransferase assay using Echo liquid handlers and two different assay technologies: AlphaLISA from PerkinElmer and EPIgeneous HTRF from Cisbio. © 2015 Society for Laboratory Automation and Screening.

Technology Transfer Report

NASA Technical Reports Server (NTRS)

2000-01-01

Since its inception, Goddard has pursued a commitment to technology transfer and commercialization. For every space technology developed, Goddard strives to identify secondary applications. Goddard then provides the technologies, as well as NASA expertise and facilities, to U.S. companies, universities, and government agencies. These efforts are based in Goddard's Technology Commercialization Office. This report presents new technologies, commercialization success stories, and other Technology Commercialization Office activities in 1999.

Quantum Dot-Fullerene Based Molecular Beacon Nanosensors for Rapid, Highly Sensitive Nucleic Acid Detection.

PubMed

Liu, Ye; Kannegulla, Akash; Wu, Bo; Cheng, Li-Jing

2018-05-15

Spherical fullerene (C 60 ) can quench the fluorescence of a quantum dot (QD) through energy transfer and charge transfer processes, with the quenching efficiency regulated by the number of proximate C 60 on each QD. With the quenching property and its small size compared with other nanoparticle-based quenchers, it is advantageous to group a QD reporter and multiple C 60 -labeled oligonucleotide probes to construct a molecular beacon (MB) probe for sensitive, robust nucleic acid detection. We demonstrated a rapid, high-sensitivity DNA detection method using the nanosensors composed of QD-C 60 based MBs carried by magnetic nanoparticles (MNPs). The assay was accelerated by first dispersing the nanosensors in analytes for highly efficient DNA capture resulting from short-distance 3-dimensional diffusion of targets to the sensor surface and then concentrating the nanosensors to a substrate by magnetic force to amplify the fluorescence signal for target quantification. The enhanced mass transport enabled a rapid detection (< 10 min) with a small sample volume (1-10 µl). The high signal-to-noise ratio produced by the QD-C 60 pairs and magnetic concentration yielded a detection limit of 100 fM (~106 target DNA copies for a 10 µl analyte). The rapid, sensitive, label-free detection method will benefit the applications in point-of-care molecular diagnostic technologies.

Photoacoustic-based detector for infrared laser spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scholz, L.; Palzer, S., E-mail: stefan.palzer@imtek.uni-freiburg.de

In this contribution, we present an alternative detector technology for use in direct absorption spectroscopy setups. Instead of a semiconductor based detector, we use the photoacoustic effect to gauge the light intensity. To this end, the target gas species is hermetically sealed under excess pressure inside a miniature cell along with a MEMS microphone. Optical access to the cell is provided by a quartz window. The approach is particularly suitable for tunable diode laser spectroscopy in the mid-infrared range, where numerous molecules exhibit large absorption cross sections. Moreover, a frequency standard is integrated into the method since the number densitymore » and pressure inside the cell are constant. We demonstrate that the information extracted by our method is at least equivalent to that achieved using a semiconductor-based photon detector. As exemplary and highly relevant target gas, we have performed direct spectroscopy of methane at the R3-line of the 2v{sub 3} band at 6046.95 cm{sup −1} using both detector technologies in parallel. The results may be transferred to other infrared-active transitions without loss of generality.« less

Technology utilization office data base analysis and design

NASA Technical Reports Server (NTRS)

Floyd, Stephen A.

1993-01-01

NASA Headquarters is placing a high priority on the transfer of NASA and NASA contractor developed technologies and expertise to the private sector and to other federal, state and local government organizations. The ultimate objective of these efforts is positive economic impact, an improved quality of life, and a more competitive U.S. posture in international markets. The Technology Utilization Office (TUO) currently serves seven states with its technology transfer efforts. Since 1989, the TUO has handled over one-thousand formal requests for NASA related technologies assistance. The technology transfer process requires promoting public awareness of NASA related soliciting requests for assistance, matching technologies to specific needs, assuring appropriate technology transfer, and monitoring and evaluating the process. Each of these activities have one very important aspect in common: the success of each is dissemination of appropriate high quality information. The purpose of the research was to establish the requirements and develop a preliminary design for a database system to increase the effectiveness and efficiency of the TUO's technology transfer function. The research was conducted following the traditional systems development life cycle methodology and was supported through the use of modern structured analysis techniques. The next section will describe the research and findings as conducted under the life cycle approach.

Space technology: A study of the significance of recognition for innovators of spinoff technologies. 1993 activities/1994, 1995 plans

NASA Technical Reports Server (NTRS)

1994-01-01

During the past 30 years as NASA has conducted technology transfer programs, it has gained considerable experience - particularly pertaining to the processes. However, three areas have not had much scrutiny: the examination of the contributions of the individuals who have developed successful spinoffs, the commercial success of the spinoffs themselves, and the degree to which they are understood by the public. In short, there has been limited evaluation to measure the success of technology transfer efforts mandated by Congress. Research conducted during the first year of a three-year NASA grant to the United States Space Foundation has taken the initial steps toward measuring the success of methodologies to accomplish that Congressionally-mandated technology transfer. In particular, the US Space Foundation, in cooperation with ARAC, technology transfer experts; JKA, a nationally recognized themed entertainment design company; and top evaluation consultants, inaugurated and evaluated a fresh approach including commercial practices to encourage, motivate, and energize technology transfer by: recognizing already successful efforts (Space Technology Hall of Fame Award), drawing potential business and industrial players into the process (Space Commerce Expo), and informing and motivating the general public (Space Technology Hall of Fame public venues). The first year's efforts are documented and directions for the future are outlined.

Multidimensional Targeting: Identifying Beneficiaries of Conditional Cash Transfer Programs

ERIC Educational Resources Information Center

Azevedo, Viviane; Robles, Marcos

2013-01-01

Conditional cash transfer programs (CCTs) have two main objectives: reducing poverty and increasing the human capital of children. To reach these objectives, transfers are given to poor households conditioned on investments in their children's education, health, and nutrition. Targeting mechanisms used by CCTs have been generally successful in…

Review and Evaluation of Wireless Power Transfer (WPT) for Electric Transit Applications

DOT National Transportation Integrated Search

2014-08-01

This research report provides a status review of emerging and existing Wireless Power Transfer (WPT) technologies applicable to electric bus (EB) and rail transit. The WPT technology options discussed, especially Inductive Power Transfer (IPT), enabl...

14 CFR 1274.915 - Restrictions on sale or transfer of technology to foreign firms or institutions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... licensing of the technology. Transfers include: (1) Sales of products or components, (2) Licenses of software or documentation related to sales of products or components, or (3) Transfers to foreign...

14 CFR § 1274.915 - Restrictions on sale or transfer of technology to foreign firms or institutions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... licensing of the technology. Transfers include: (1) Sales of products or components, (2) Licenses of software or documentation related to sales of products or components, or (3) Transfers to foreign...

14 CFR 1274.915 - Restrictions on sale or transfer of technology to foreign firms or institutions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... licensing of the technology. Transfers include: (1) Sales of products or components, (2) Licenses of software or documentation related to sales of products or components, or (3) Transfers to foreign...

Applications of aerospace technology in industry, a technology transfer profile: Lubrication

NASA Technical Reports Server (NTRS)

Kottenstette, J. P.; Freeman, J. E.; Heins, C. R.; Hildred, W. M.; Johnson, F. D.; Staskin, E. R.

1971-01-01

Technology transfer in the lubrication field is discussed in terms of the movement of NASA-generated lubrication technology into the private sector as affected by evolving industrial requirements. An overview of the field is presented, and NASA technical contributions to lubrication technology are described. Specific examples in which these technologies have been used in the private sector are summarized.

Generation of TALE nickase-mediated gene-targeted cows expressing human serum albumin in mammary glands.

PubMed

Luo, Yan; Wang, Yongsheng; Liu, Jun; Cui, Chenchen; Wu, Yongyan; Lan, Hui; Chen, Qi; Liu, Xu; Quan, Fusheng; Guo, Zekun; Zhang, Yong

2016-02-08

Targeting exogenous genes at milk protein loci via gene-targeting technology is an ideal strategy for producing large quantities of pharmaceutical proteins. Transcription-activator-like effector (TALE) nucleases (TALENs) are an efficient genome-editing tool. However, the off-target effects may lead to unintended gene mutations. In this study, we constructed TALENs and TALE nickases directed against exon 2 of the bovine β-lactoglobulin (BLG) locus. The nickases can induce a site-specific DNA single-strand break, without inducing double-strand break and nonhomologous end joining mediated gene mutation, and lower cell apoptosis rate than TALENs. After co-transfecting the bovine fetal fibroblasts with human serum albumin (HSA) gene-targeting vector and TALE nickase expression vectors, approximately 4.8% (40/835) of the cell clones contained HSA at BLG locus. Unexpectedly, one homozygous gene-targeted cell clone (1/835, 0.1%) was obtained by targeting both alleles of BLG in a single round of transfection. The recombinant protein mimicking the endogenous BLG was highly expressed and correctly folded in the mammary glands of the targeted cows, and the expression level of HSA was significantly increased in the homozygous targeted cows. Results suggested that the combination of TALE nickase-mediated gene targeting and somatic cell nuclear transfer is a feasible and safe approach in producing gene-targeted livestock.

Spinoff, 1990

NASA Technical Reports Server (NTRS)

Haggerty, James J.

1990-01-01

This publication is intended to foster the aim of the NASA Technology Utilization Program by heightening awareness of the NASA technology available for transfer and its potential for benefits realized by secondary applications. Spinoff 1990 is organized in three main sections. Section 1 outlines NASA's mainline effort, the major programs that generate new technology and therefore replenish and expand the bank of knowledge available for transfer. Section 2 contains a representative sampling of spinoff products that resulted from secondary application of technology originally developed to meet mainline goals. Section 3 describes the various mechanisms NASA employs to stimulate technology transfer and lists, in an appendix, contact sources for further information about the Technology Utilization Program.

Applications of aerospace technology in the electric power industry

NASA Technical Reports Server (NTRS)

1973-01-01

An overview of the electric power industry, selected NASA contributions to progress in the industry, linkages affecting the transfer and diffusion of technology, and, finally, a perspective on technology transfer issues are presented.

The ARC organizational and community intervention strategy for implementing evidence-based children's mental health treatments.

PubMed

Glisson, Charles; Schoenwald, Sonja K

2005-12-01

This paper reviews the implications of organizational and community intervention research for the implementation of effective mental health treatments in usual community practice settings. The paper describes an organizational and community intervention model named ARC for Availability, Responsiveness and Continuity, that was designed to support the improvement of social and mental health services for children. The ARC model incorporates intervention components from organizational development, interorganizational domain development, the diffusion of innovation, and technology transfer that target social, strategic, and technological factors in effective children's services. This paper also describes a current NIMH-funded study that is using the ARC intervention model to support the implementation of an evidence-based treatment, Multisystemic Therapy (MST), for delinquent youth in extremely rural, impoverished communities in the Appalachian Mountains of East Tennessee.

Application of Sensor Technology for the Efficient Positioningand Assembling of Ship Blocks

NASA Astrophysics Data System (ADS)

Lee, Sangdon; SeongbaeEun; Jung, Jai Jin; Song, Hacheol

2010-09-01

This paper proposes the application of sensor technology to assemble ship blocks efficiently. A sensor-based monitoring system is designed and implemented to improve shipbuilding productivity by reducing the labor cost for the adjustment of adequate positioning between ship blocks during pre-erection or erection stage. For the real-time remote monitoring of relative distances between two ship blocks, sensor nodes are applied to measure the distances between corresponding target points on the blocks. Highly precise positioning data can be transferred to a monitoring server via wireless network, and analyzed to support the decision making which needs to determine the next construction process; further adjustment or seam welding between the ship blocks. The developed system is expected to put to practical use, and increase the productivity during ship blocks assembly.

Bioprocess development workflow: Transferable physiological knowledge instead of technological correlations.

PubMed

Reichelt, Wieland N; Haas, Florian; Sagmeister, Patrick; Herwig, Christoph

2017-01-01

Microbial bioprocesses need to be designed to be transferable from lab scale to production scale as well as between setups. Although substantial effort is invested to control technological parameters, usually the only true constant parameter is the actual producer of the product: the cell. Hence, instead of solely controlling technological process parameters, the focus should be increasingly laid on physiological parameters. This contribution aims at illustrating a workflow of data life cycle management with special focus on physiology. Information processing condenses the data into physiological variables, while information mining condenses the variables further into physiological descriptors. This basis facilitates data analysis for a physiological explanation for observed phenomena in productivity. Targeting transferability, we demonstrate this workflow using an industrially relevant Escherichia coli process for recombinant protein production and substantiate the following three points: (1) The postinduction phase is independent in terms of productivity and physiology from the preinduction variables specific growth rate and biomass at induction. (2) The specific substrate uptake rate during induction phase was found to significantly impact the maximum specific product titer. (3) The time point of maximum specific titer can be predicted by an easy accessible physiological variable: while the maximum specific titers were reached at different time points (19.8 ± 7.6 h), those maxima were reached all within a very narrow window of cumulatively consumed substrate dSn (3.1 ± 0.3 g/g). Concluding, this contribution provides a workflow on how to gain a physiological view on the process and illustrates potential benefits. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 33:261-270, 2017. © 2016 American Institute of Chemical Engineers.

Promoting interdomain analogical transfer: When creating a problem helps to solve a problem.

PubMed

Minervino, Ricardo A; Olguín, Valeria; Trench, Máximo

2017-02-01

Research on analogical thinking has devised several ways of promoting an abstract encoding of base analogs, thus rendering them more retrievable during later encounters with similar situations lacking surface similarities. Recent studies have begun to explore ways of facilitating transfer at retrieval time, which could facilitate the retrieval of distant analogs learned within contexts that were not specially directed to emphasize their abstract structure. Such studies demonstrate that comparing a target problem to an analogous problem helps students retrieve base analogs that lack surface similarities. To devise more portable ways of enhancing analogical transfer, Experiment 1 replicated Kurtz and Loewenstein's (Memory & Cognition, 35, 334-341, 2007) target-comparison procedure with an additional condition in which participants compared the target to a nonanalogous problem before attempting to reach its solution. Although comparing two analogous targets outperformed the standard transfer condition in promoting analogical transfer, comparing nonanalogous problems did not yield a transfer advantage. Based on prior studies that showed that the activity of creating analogous problems during their initial encoding elicits a more abstract representation of base analogs, in Experiment 2 we assessed whether constructing a second analogous target problem at retrieval time helps participants retrieve superficially dissimilar base analogs. As predicted, target invention increased the retrieval of distant sources. In both experiments we found an association between the quality of the generated schemas and the probability of retrieving a distant base analog from memory.

The role of technology in critical care nursing.

PubMed

Crocker, Cheryl; Timmons, Stephen

2009-01-01

This paper is a report of a study to identify the meaning for critical care nurses of technology related to weaning from mechanical ventilation and to explore how that technology was used in practice. The literature concerned with the development of critical care (intensive care and high dependency units) focuses mainly on innovative medical technology. Although this use of technology in critical care is portrayed as new, it actually represents a transfer of technology from operating theatres. An ethnographic study was conducted and data were collected on one critical care unit in a large teaching hospital over a 6-month period in 2004. The methods included participant observation, interviews and the collection of field notes. The overall theme 'The nursing-technology relation' was identified. This comprised three sub-themes: definition of technology, technology transferred and technology transformed. Novice nurses took a task-focussed approach to weaning, treating it as a 'medical' technology transferred to them from doctors. Expert nurses used technology differently and saw its potential to become a 'nursing technology'. Nurses need to examine how they can adapt and to 'reconfigure' technology so that it can be transformed into a nursing technology. Those technologies that do not fit with nursing may have no place there. Rather than simply extending and expanding their roles through technology transfer, nurses should transform those technologies that preserve the essence of nursing and can contribute to a positive outcome for patients.

Technology transfer for DOE's office of buildings and community systems: assessment and strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, M.A.; Jones, D.W.; Kolb, J.O.

1986-07-01

The uninterrupted availability of oil supplies over the past several years and the moderation of energy price increases has sent signals to consumers and decision-makers in the buildings industry that the ''energy crisis'' is over. As a result, efforts to promote energy-conserving technologies must emphasize benefits other than BTU savings. The improved ambience of daylit spaces and the lower first costs associated with installing down-sized HVAC systems in ''tight'' buildings are examples of benefits which are likely to more influential than estimates of energy saved. Successful technology transfer requires that an R and D product have intrinsic value and thatmore » these values be effectively communicated to potential users. Active technology transfer programs are more effective than passive ones. Transfer activities should involve more than simply making information available to those who seek it. Information should be tailored to meet the needs of specific user groups and disseminated through those channels which users normally employ. In addition to information dissemination, successful technology transfer involves the management of intellectual property, including patented inventions, copyrights, technical data, and rights to future inventions. When the public can best benefit from an invention through commercialization of a new product, the exclusivity necessary to protect the investment from copiers should be provided. Most federal technology transfer programs concentrate on information exchange and largely avoid intellectual property transfers.« less

Context transfer in reinforcement learning using action-value functions.

PubMed

Mousavi, Amin; Nadjar Araabi, Babak; Nili Ahmadabadi, Majid

2014-01-01

This paper discusses the notion of context transfer in reinforcement learning tasks. Context transfer, as defined in this paper, implies knowledge transfer between source and target tasks that share the same environment dynamics and reward function but have different states or action spaces. In other words, the agents learn the same task while using different sensors and actuators. This requires the existence of an underlying common Markov decision process (MDP) to which all the agents' MDPs can be mapped. This is formulated in terms of the notion of MDP homomorphism. The learning framework is Q-learning. To transfer the knowledge between these tasks, the feature space is used as a translator and is expressed as a partial mapping between the state-action spaces of different tasks. The Q-values learned during the learning process of the source tasks are mapped to the sets of Q-values for the target task. These transferred Q-values are merged together and used to initialize the learning process of the target task. An interval-based approach is used to represent and merge the knowledge of the source tasks. Empirical results show that the transferred initialization can be beneficial to the learning process of the target task.

Context Transfer in Reinforcement Learning Using Action-Value Functions

PubMed Central

Mousavi, Amin; Nadjar Araabi, Babak; Nili Ahmadabadi, Majid

2014-01-01

This paper discusses the notion of context transfer in reinforcement learning tasks. Context transfer, as defined in this paper, implies knowledge transfer between source and target tasks that share the same environment dynamics and reward function but have different states or action spaces. In other words, the agents learn the same task while using different sensors and actuators. This requires the existence of an underlying common Markov decision process (MDP) to which all the agents' MDPs can be mapped. This is formulated in terms of the notion of MDP homomorphism. The learning framework is Q-learning. To transfer the knowledge between these tasks, the feature space is used as a translator and is expressed as a partial mapping between the state-action spaces of different tasks. The Q-values learned during the learning process of the source tasks are mapped to the sets of Q-values for the target task. These transferred Q-values are merged together and used to initialize the learning process of the target task. An interval-based approach is used to represent and merge the knowledge of the source tasks. Empirical results show that the transferred initialization can be beneficial to the learning process of the target task. PMID:25610457

KSC-2013-3578

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Carol Craig, founder and CEO of Craig Technologies, discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

Joining Together for a Common Cause – Interagency Collaboration to Fight disease

USDA-ARS?s Scientific Manuscript database

In addition to the economic and technical benefits of technology transfer, there is the human element-how technology development and technology transfer can make a difference in people’s lives. We will share compelling stories of how individuals have directly benefited from technology development an...

Seeing the Forest and the Trees: Western Forestry Systems and Soviet Engineers, 1955-1964.

PubMed

Kochetkova, Elena

This article examines the transfer of technology from Finnish enterprises to Soviet industry during the USSR's period of technological modernization between 1955 and 1964. It centers on the forestry sector, which was a particular focus of modernization programs and a key area for the transfer of foreign techniques and expertise. The aim of the article is to investigate the role of trips made by Soviet specialists to foreign (primarily Finnish) enterprises in order to illustrate the nontechnological influences that occurred during the transfer of technologies across the cold war border. To do so, the article is divided into two parts: the first presents a general analysis of technology transfer from a micro-level perspective, while the second investigates the cultural influences behind technological transfer in the Soviet-Finnish case. This study contends that although the Soviet government expected its specialists to import advanced foreign technical experience, they brought not only the technologies and expertise needed for modernizing the industry, but also a changed view on Soviet workplace management and everyday practices.

The Role of Empirical Evidence for Transferring a New Technology to Industry

NASA Astrophysics Data System (ADS)

Baldassarre, Maria Teresa; Bruno, Giovanni; Caivano, Danilo; Visaggio, Giuseppe

Technology transfer and innovation diffusion are key success factors for an enterprise. The shift to a new software technology involves, on one hand, inevitable changes to ingrained and familiar processes and, on the other, requires training, changes in practices and commitment on behalf of technical staff and management. Nevertheless, industry is often reluctant to innovation due to the changes it determines. The process of innovation diffusion is easier if the new technology is supported by empirical evidence. In this sense our conjecture is that Empirical Software Engineering (ESE) serves as means for validating and transferring a new technology within production processes. In this paper, the authors report their experience of a method, Multiview Framework, defined in the SERLAB research laboratory as support for designing and managing a goal oriented measurement program that has been validated through various empirical studies before being transferred to an Italian SME. Our discussion points out the important role of empirical evidence for obtaining management commitment and buy-in on behalf of technical staff, and for making technological transfer possible.

Laser profilometer module based on a low-temperature cofired ceramic substrate

NASA Astrophysics Data System (ADS)

Heikkinen, Veli; Heikkinen, Mikko; Keranen, Kimmo; Mitikka, Risto S.; Putila, Veli-Pekka; Tukkiniemi, Kari

2005-09-01

We realized a laser profilometer module using low temperature cofired ceramics technology. The device consists of a vertical-cavity surface-emitting laser as the light source and a complementary metal oxide semiconductor image sensor as the detector. The laser transmitter produces a thin light stripe on the measurable object, and the receiver calculates the distance profile using triangulation. Because the design of optoelectronic modules, such as the laser profilometer, is usually carried out using specialized software, its electronic compatibility is very important. We developed a data transmission network using commercial optical, electrical, and mechanical design software, which enabled us to electronically transfer data between the designers. The module electronics were realized with multilayer ceramics technology that eases component assembly by providing precision alignment features in the substrate. The housing was manufactured from aluminum using electronic data transfer from the mechanical design software to the five-axis milling workstation. Target distance profiles were obtained from 100 points with an accuracy varying from 0.1 mm at a 5-cm distance to 2 cm at 1.5 m. The module has potential for distance measurement in portable devices where small size, light weight, and low power consumption are important.

Missing Modality Transfer Learning via Latent Low-Rank Constraint.

PubMed

Ding, Zhengming; Shao, Ming; Fu, Yun

2015-11-01

Transfer learning is usually exploited to leverage previously well-learned source domain for evaluating the unknown target domain; however, it may fail if no target data are available in the training stage. This problem arises when the data are multi-modal. For example, the target domain is in one modality, while the source domain is in another. To overcome this, we first borrow an auxiliary database with complete modalities, then consider knowledge transfer across databases and across modalities within databases simultaneously in a unified framework. The contributions are threefold: 1) a latent factor is introduced to uncover the underlying structure of the missing modality from the known data; 2) transfer learning in two directions allows the data alignment between both modalities and databases, giving rise to a very promising recovery; and 3) an efficient solution with theoretical guarantees to the proposed latent low-rank transfer learning algorithm. Comprehensive experiments on multi-modal knowledge transfer with missing target modality verify that our method can successfully inherit knowledge from both auxiliary database and source modality, and therefore significantly improve the recognition performance even when test modality is inaccessible in the training stage.

Program for transfer research and impact studies

NASA Technical Reports Server (NTRS)

Kottenstette, J. P.; Rusnak, J. J.; Staskin, E. R.

1972-01-01

The progress made in achieving TRIS research objectives during the first six months of 1972 is reviewed. The Tech Brief-Technical Support Package Program and technology transfer profiles are presented along with summaries of technology transfer in nondestructive testing, and visual display systems.

Tools and technologies for expert systems: A human factors perspective

NASA Technical Reports Server (NTRS)

Rajaram, Navaratna S.

1987-01-01

It is widely recognized that technologies based on artificial intelligence (AI), especially expert systems, can make significant contributions to the productivity and effectiveness of operations of information and knowledge intensive organizations such as NASA. At the same time, these being relatively new technologies, there is the problem of transfering technology to key personnel of such organizations. The problems of examining the potential of expert systems and of technology transfer is addressed in the context of human factors applications. One of the topics of interest was the investigation of the potential use of expert system building tools, particularly NEXPERT as a technology transfer medium. Two basic conclusions were reached in this regard. First, NEXPERT is an excellent tool for rapid prototyping of experimental expert systems, but not ideal as a delivery vehicle. Therefore, it is not a substitute for general purpose system implementation languages such a LISP or C. This assertion probably holds for nearly all such tools on the market today. Second, an effective technology transfer mechanism is to formulate and implement expert systems for problems which members of the organization in question can relate to. For this purpose, the LIghting EnGineering Expert (LIEGE) was implemented using NEXPERT as the tool for technology transfer and to illustrate the value of expert systems to the activities of the Man-System Division.

Proton-deuteron double scattering

NASA Technical Reports Server (NTRS)

Wilson, J. W.

1974-01-01

A simple but accurate form for the proton-deuteron elastic double scattering amplitude, which includes both projectile and target recoil motion and is applicable at all momentum transfer, is derived by taking advantage of the restricted range of Fermi momentum allowed by the deuteron wave function. This amplitude can be directly compared to approximations which have neglected target recoil or are limited to small momentum transfer; the target recoil and large momentum transfer effects are evaluated explicitly within the context of a Gaussian model.

Solar sail trajectory design in the Earth-Moon circular restricted three body problem

NASA Astrophysics Data System (ADS)

Das, Ashwati

The quest to explore the Moon has helped resolve scientific questions, has spurred leaps in technology development, and has revealed Earth's celestial companion to be a gateway to other destinations. With a renewed focus on returning to the Moon in this decade, alternatives to chemical propulsion systems are becoming attractive methods to efficiently use scarce resources and support extended mission durations. Thus, an investigation is conducted to develop a general framework, that facilitates propellant-free Earth-Moon transfers by exploiting sail dynamics in combination with advantageous transfer options offered in the Earth-Moon circular restricted multi-body dynamical model. Both periodic orbits in the vicinity of the Earth-Moon libration points, and lunar-centric long-term capture orbits are incorporated as target destinations to demonstrate the applicability of the general framework to varied design scanarios, each incorporating a variety of complexities and challenges. The transfers are comprised of three phases - a spiral Earth escape, a transit period, and, finally, the capture into a desirable orbit in the vicinity of the Moon. The Earth-escape phase consists of spiral trajectories constructed using three different sail steering strategies - locally optimal, on/off and velocity tangent. In the case of the Earth-libration point transfers, naturally occurring flow structures (e.g., invariant manifolds) arising from the mutual gravitational interaction of the Earth and Moon are exploited to link an Earth departure spiral with a destination orbit. In contrast, sail steering alone is employed to establish a link between the Earth-escape phase and capture orbits about the Moon due to a lack of applicable natural structures for the required connection. Metrics associated with the transfers including flight-time and the influence of operational constraints, such as occultation events, are investigated to determine the available capabilities for Earth-Moon transfers given current sail technology levels. Although the implemented steering laws suffice to generate baseline paths, infeasible turn rate demands placed on the sail are also investigated to explore the technical hurdles in designing Earth-Moon transfers. The methodologies are suitable for a variety of mission scenarios and sail configurations, rendering the resulting trajectories valuable for a diverse range of applications.

Applications of aerospace technology in biology and medicine

NASA Technical Reports Server (NTRS)

Rouse, D. J.

1983-01-01

Utilization of NASA technology and its application to medicine is discussed. The introduction of new or improved commercially available medical products and incorporation of aerospace technology is outlined. A biopolar donor-recipient model of medical technology transfer is presented to provide a basis for the methodology. The methodology is designed to: (1) identify medical problems and NASA technology that, in combination, constitute opportunities for successful medical products; (2) obtain the early participation of industry in the transfer process; and (3) obtain acceptance by the medical community of new medical products based on NASA technology. Two commercial transfers were completed: the ocular screening device, a system for quick detection of vision problems in preschool children, and Porta-Fib III, a hospital monitoring unit. Two institutional transfers were completed: implant materials testing, the application of NASA fracture control technology to improve reliability of metallic prostheses, and incinerator monitoring, a quadrupole mass spectrometer to monitor combustion products of municipal incinerators. Mobility aids for the blind and ultrasound diagnosis of burn depth are also studied.

Research to practice in addiction treatment: key terms and a field-driven model of technology transfer.

PubMed

2011-09-01

The transfer of new technologies (e.g., evidence-based practices) into substance abuse treatment organizations often occurs long after they have been developed and shown to be effective. Transfer is slowed, in part, due to a lack of clear understanding about all that is needed to achieve full implementation of these technologies. Such misunderstanding is exacerbated by inconsistent terminology and overlapping models of an innovation, including its development and validation, dissemination to the public, and implementation or use in the field. For this reason, a workgroup of the Addiction Technology Transfer Center (ATTC) Network developed a field-driven conceptual model of the innovation process that more precisely defines relevant terms and concepts and integrates them into a comprehensive taxonomy. The proposed definitions and conceptual framework will allow for improved understanding and consensus regarding the distinct meaning and conceptual relationships between dimensions of the technology transfer process and accelerate the use of evidence-based practices. Copyright © 2011 Elsevier Inc. All rights reserved.

Biosensor technology: technology push versus market pull.

PubMed

Luong, John H T; Male, Keith B; Glennon, Jeremy D

2008-01-01

Biosensor technology is based on a specific biological recognition element in combination with a transducer for signal processing. Since its inception, biosensors have been expected to play a significant analytical role in medicine, agriculture, food safety, homeland security, environmental and industrial monitoring. However, the commercialization of biosensor technology has significantly lagged behind the research output as reflected by a plethora of publications and patenting activities. The rationale behind the slow and limited technology transfer could be attributed to cost considerations and some key technical barriers. Analytical chemistry has changed considerably, driven by automation, miniaturization, and system integration with high throughput for multiple tasks. Such requirements pose a great challenge in biosensor technology which is often designed to detect one single or a few target analytes. Successful biosensors must be versatile to support interchangeable biorecognition elements, and in addition miniaturization must be feasible to allow automation for parallel sensing with ease of operation at a competitive cost. A significant upfront investment in research and development is a prerequisite in the commercialization of biosensors. The progress in such endeavors is incremental with limited success, thus, the market entry for a new venture is very difficult unless a niche product can be developed with a considerable market volume.

NASA technology transfer network communications and information system: TUNS user survey

NASA Technical Reports Server (NTRS)

1992-01-01

Applied Expertise surveyed the users of the deployed Technology Utilization Network System (TUNS) and surveyed prospective new users in order to gather background information for developing the Concept Document of the system that will upgrade and replace TUNS. Survey participants broadly agree that automated mechanisms for acquiring, managing, and disseminating new technology and spinoff benefits information can and should play an important role in meeting NASA technology utilization goals. However, TUNS does not meet this need for most users. The survey describes a number of systematic improvements that will make it easier to use the technology transfer mechanism, and thus expedite the collection and dissemination of technology information. The survey identified 26 suggestions for enhancing the technology transfer system and related processes.

The process for technology transfer in Baltimore

NASA Technical Reports Server (NTRS)

Golden, T. S.

1978-01-01

Ingredients essential for a successful decision process relative to proper technological choices for a large city were determined during four years of experience in the NASA/Baltimore Applications Project. The general approach, rationale, and process of technology transfer are discussed.

Transfer Learning of Classification Rules for Biomarker Discovery and Verification from Molecular Profiling Studies

PubMed Central

Ganchev, Philip; Malehorn, David; Bigbee, William L.; Gopalakrishnan, Vanathi

2013-01-01

We present a novel framework for integrative biomarker discovery from related but separate data sets created in biomarker profiling studies. The framework takes prior knowledge in the form of interpretable, modular rules, and uses them during the learning of rules on a new data set. The framework consists of two methods of transfer of knowledge from source to target data: transfer of whole rules and transfer of rule structures. We evaluated the methods on three pairs of data sets: one genomic and two proteomic. We used standard measures of classification performance and three novel measures of amount of transfer. Preliminary evaluation shows that whole-rule transfer improves classification performance over using the target data alone, especially when there is more source data than target data. It also improves performance over using the union of the data sets. PMID:21571094

Deep transfer learning for automatic target classification: MWIR to LWIR

NASA Astrophysics Data System (ADS)

Ding, Zhengming; Nasrabadi, Nasser; Fu, Yun

2016-05-01

Publisher's Note: This paper, originally published on 5/12/2016, was replaced with a corrected/revised version on 5/18/2016. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Library Customer Service for assistance. When dealing with sparse or no labeled data in the target domain, transfer learning shows its appealing performance by borrowing the supervised knowledge from external domains. Recently deep structure learning has been exploited in transfer learning due to its attractive power in extracting effective knowledge through multi-layer strategy, so that deep transfer learning is promising to address the cross-domain mismatch. In general, cross-domain disparity can be resulted from the difference between source and target distributions or different modalities, e.g., Midwave IR (MWIR) and Longwave IR (LWIR). In this paper, we propose a Weighted Deep Transfer Learning framework for automatic target classification through a task-driven fashion. Specifically, deep features and classifier parameters are obtained simultaneously for optimal classification performance. In this way, the proposed deep structures can extract more effective features with the guidance of the classifier performance; on the other hand, the classifier performance is further improved since it is optimized on more discriminative features. Furthermore, we build a weighted scheme to couple source and target output by assigning pseudo labels to target data, therefore we can transfer knowledge from source (i.e., MWIR) to target (i.e., LWIR). Experimental results on real databases demonstrate the superiority of the proposed algorithm by comparing with others.

The simultaneous isolation of multiple high and low frequent T-cell populations from donor peripheral blood mononuclear cells using the major histocompatibility complex I-Streptamer isolation technology.

PubMed

Roex, Marthe C J; Hageman, Lois; Heemskerk, Matthias T; Veld, Sabrina A J; van Liempt, Ellis; Kester, Michel G D; Germeroth, Lothar; Stemberger, Christian; Falkenburg, J H Frederik; Jedema, Inge

2018-04-01

Adoptive transfer of donor-derived T cells can be applied to improve immune reconstitution in immune-compromised patients after allogeneic stem cell transplantation. The separation of beneficial T cells from potentially harmful T cells can be achieved by using the major histocompatibility complex (MHC) I-Streptamer isolation technology, which has proven its feasibility for the fast and pure isolation of T-cell populations with a single specificity. We have analyzed the feasibility of the simultaneous isolation of multiple antigen-specific T-cell populations in one procedure by combining different MHC I-Streptamers. First, the effect of combining different amounts of MHC I-Streptamers used in the isolation procedure on the isolation efficacy of target antigen-specific T cells and on the number of off-target co-isolated contaminating cells was assessed. The feasibility of this approach was demonstrated in large-scale validation procedures targeting both high and low frequent T-cell populations using the Good Manufacturing Practice (GMP)-compliant CliniMACS Plus device. T-cell products targeting up to 24 different T-cell populations could be isolated in one, simultaneous MHC I-Streptamer procedure, by adjusting the amount of MHC I- Streptamers per target antigen-specific T-cell population. Concurrently, the co-isolation of potentially harmful contaminating T cells remained below our safety limit. This technology allows the reproducible isolation of high and low frequent T-cell populations. However, the expected therapeutic relevance of direct clinical application without in vitro expansion of these low frequent T-cell populations is questionable. This study provides a feasible, fast and safe method for the generation of highly personalized MHC I-Streptamer isolated T-cell products for adoptive immunotherapy. Copyright © 2018 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

KSC-2013-3572

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Mike Lester, Research and Technology Partnership manager at NASA's Kennedy Space Center in Florida, discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

KSC-2013-3573

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Joni Richards, Technology Infusion specialist at NASA's Kennedy Space Center in Florida, discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

Implementing the millennium development food security goals Challenges of the southern African context

NASA Astrophysics Data System (ADS)

Love, David; Twomlow, Steve; Mupangwa, Walter; van der Zaag, Pieter; Gumbo, Bekithemba

The Millennium Development Goals’ target to halve the proportion of people who suffer from hunger is extremely important in southern Africa, where food security has become increasingly problematic over the last 20 years. One “quick-win” proposal is replenishment of soil nutrients for smallholder farmers, through free or subsidised chemical fertilisers. Other proposals include appropriate irrigation technology, improved inputs and interventions targeted at women. Analysis of over 10 years of agro-hydrological and agro-economic studies from southern African show that a different approach is required to interventions proposed. There are sustainability problems with free chemical fertiliser due to transport costs and ancillary costs. Furthermore, recent studies in Zimbabwe and Mozambique show that significant increases in yield can only be obtained when soil fertility management is combined with good crop husbandry, e.g. timely planting and weeding. Ongoing replenishment of fertility would be dependent on a continued free or subsidised fertiliser supply, and transport system. Increasing access to irrigation will help, but is not the only solution and cannot reach even a majority of farmers. It has been determined that short dryspells are often the major cause of low yields in sub-Saharan Africa. Soil-water conservation approaches, e.g. winter weeding and conservation tillage, can reduce risk and increase yield. The following specific recommendations are made for urgent interventions to contribute sustainably to food security in southern Africa: (i) To increases access to fertiliser, consider development of strong input markets at end-user level. (ii) Intensification of technology transfer, focusing on capacity building for transfer of existing technologies and much closer collaboration between state and NGO sectors, agronomists and water engineers. (iii) Increasing the uptake of soil-water conservation methods, including conservation tillage and weeding, and supplementary irrigation to minimise adverse effects of dryspells, through investments in farmer training. (iv) Linking crop development strategies to livestock development practices and strategies. (v) Developing non-agro-based livelihood strategies in marginal lands.

A case history of technology transfer

NASA Technical Reports Server (NTRS)

1981-01-01

A sequence of events, occurring over the last 25 years, are described that chronicle the evolution of ion-bombardment electric propulsion technology. Emphasis is placed on the latter phases of this evolution, where special efforts were made to pave the way toward the use of this technology in operational space flight systems. These efforts consisted of a planned program to focus the technology toward its end applications and an organized process that was followed to transfer the technology from the research-technology NASA Center to the user-development NASA Center and its industry team. Major milestones in this evolution, which are described, include the development of thruster technology across a large size range, the successful completion of two space electric rocket tests, SERT I and SERT II, development of power-processing technology for electric propulsion, completion of a program to make the technology ready for flight system development, and finally the technology transfer events.

NASA's Technology Transfer Program for the Early Detection of Breast Cancer

NASA Technical Reports Server (NTRS)

Schmidt, Gregory; Frey, Mary Anne; Vernikos, Joan; Winfield, Daniel; Dalton, Bonnie P. (Technical Monitor)

1996-01-01

The National Aeronautics and Space Administration (NASA) has led the development of advanced imaging sensors and image processing technologies for space science and Earth science missions. NASA considers the transfer and commercialization of such technologies a fundamental mission of the agency. Over the last two years, efforts have been focused on the application of aerospace imaging and computing to the field of diagnostic imaging, specifically to breast cancer imaging. These technology transfer efforts offer significant promise in helping in the national public health priority of the early detection of breast cancer.

NASA Intellectual Property Negotiation Practices and their Relationship to Quantitative Measures of Technology Transfer

NASA Technical Reports Server (NTRS)

Bush, Lance B.

1997-01-01

In the current political climate NASA must be able to show reliable measures demonstrating successful technology transfer. The currently available quantitative data of intellectual property technology transfer efforts portray a less than successful performance. In this paper, the use of only quantitative values for measurement of technology transfer is shown to undervalue the effort. In addition, NASA's current policy in negotiating intellectual property rights results in undervalued royalty rates. NASA has maintained that it's position of providing public good precludes it from negotiating fair market value for its technology and instead has negotiated for reasonable cost in order to recover processing fees. This measurement issue is examined and recommendations made which include a new policy regarding the intellectual property rights negotiation, and two measures to supplement the intellectual property measures.

Multifunctional cell-culture platform for aligned cell sheet monitoring, transfer printing, and therapy.

PubMed

Kim, Seok Joo; Cho, Hye Rim; Cho, Kyoung Won; Qiao, Shutao; Rhim, Jung Soo; Soh, Min; Kim, Taeho; Choi, Moon Kee; Choi, Changsoon; Park, Inhyuk; Hwang, Nathaniel S; Hyeon, Taeghwan; Choi, Seung Hong; Lu, Nanshu; Kim, Dae-Hyeong

2015-03-24

While several functional platforms for cell culturing have been proposed for cell sheet engineering, a soft integrated system enabling in vitro physiological monitoring of aligned cells prior to their in vivo applications in tissue regeneration has not been reported. Here, we present a multifunctional, soft cell-culture platform equipped with ultrathin stretchable nanomembrane sensors and graphene-nanoribbon cell aligners, whose system modulus is matched with target tissues. This multifunctional platform is capable of aligning plated cells and in situ monitoring of cellular physiological characteristics during proliferation and differentiation. In addition, it is successfully applied as an in vitro muscle-on-a-chip testing platform. Finally, a simple but high-yield transfer printing mechanism is proposed to deliver cell sheets for scaffold-free, localized cell therapy in vivo. The muscle-mimicking stiffness of the platform allows the high-yield transfer printing of multiple cell sheets and results in successful therapies in diseased animal models. Expansion of current results to stem cells will provide unique opportunities for emerging classes of tissue engineering and cell therapy technologies.

A SiC MOSFET Based Inverter for Wireless Power Transfer Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Onar, Omer C; Chinthavali, Madhu Sudhan; Campbell, Steven L

2014-01-01

In a wireless power transfer (WPT) system, efficiency of the power conversion stages is crucial so that the WPT technology can compete with the conventional conductive charging systems. Since there are 5 or 6 power conversion stages, each stage needs to be as efficient as possible. SiC inverters are crucial in this case; they can handle high frequency operation and they can operate at relatively higher temperatures resulting in reduces cost and size for the cooling components. This study presents the detailed power module design, development, and fabrication of a SiC inverter. The proposed inverter has been tested at threemore » center frequencies that are considered for the WPT standardization. Performance of the inverter at the same target power transfer level is analyzed along with the other system components. In addition, another SiC inverter has been built in authors laboratory by using the ORNL designed and developed SiC modules. It is shown that the inverter with ORNL packaged SiC modules performs simular to that of the inverter having commercially available SiC modules.« less

Streaming Support for Data Intensive Cloud-Based Sequence Analysis

PubMed Central

Issa, Shadi A.; Kienzler, Romeo; El-Kalioby, Mohamed; Tonellato, Peter J.; Wall, Dennis; Bruggmann, Rémy; Abouelhoda, Mohamed

2013-01-01

Cloud computing provides a promising solution to the genomics data deluge problem resulting from the advent of next-generation sequencing (NGS) technology. Based on the concepts of “resources-on-demand” and “pay-as-you-go”, scientists with no or limited infrastructure can have access to scalable and cost-effective computational resources. However, the large size of NGS data causes a significant data transfer latency from the client's site to the cloud, which presents a bottleneck for using cloud computing services. In this paper, we provide a streaming-based scheme to overcome this problem, where the NGS data is processed while being transferred to the cloud. Our scheme targets the wide class of NGS data analysis tasks, where the NGS sequences can be processed independently from one another. We also provide the elastream package that supports the use of this scheme with individual analysis programs or with workflow systems. Experiments presented in this paper show that our solution mitigates the effect of data transfer latency and saves both time and cost of computation. PMID:23710461

KSC-2013-3577

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Percy Luney of Space Florida discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

TECHNOLOGY TRANSFER ENVIRONMENTAL REGULATIONS AND TECHNOLOGY : CONTROL OF PATHOGENS IN MUNICIPAL WASTEWATER SLUDGE

EPA Science Inventory

This 71 - page Technology Transfer Environmental Regulations and echnology publication describes the Federal requirements promulgated in 1979 for reducing pathogens n wastewater sludge and provides guidance in determining whether individual sludge treatment andated or particular ...

Bead mediated separation of microparticles in droplets.

PubMed

Wang, Sida; Sung, Ki-Joo; Lin, Xiaoxia Nina; Burns, Mark A

2017-01-01

Exchange of components such as particles and cells in droplets is important and highly desired in droplet microfluidic assays, and many current technologies use electrical or magnetic fields to accomplish this process. Bead-based microfluidic techniques offer an alternative approach that uses the bead's solid surface to immobilize targets like particles or biological material. In this paper, we demonstrate a bead-based technique for exchanging droplet content by separating fluorescent microparticles in a microfluidic device. The device uses posts to filter surface-functionalized beads from a droplet and re-capture the filtered beads in a new droplet. With post spacing of 7 μm, beads above 10 μm had 100% capture efficiency. We demonstrate the efficacy of this system using targeted particles that bind onto the functionalized beads and are, therefore, transferred from one solution to another in the device. Binding capacity tests performed in the bulk phase showed an average binding capacity of 5 particles to each bead. The microfluidic device successfully separated the targeted particles from the non-targeted particles with up to 98% purity and 100% yield.

Bead mediated separation of microparticles in droplets

PubMed Central

Sung, Ki-Joo; Lin, Xiaoxia Nina; Burns, Mark A.

2017-01-01

Exchange of components such as particles and cells in droplets is important and highly desired in droplet microfluidic assays, and many current technologies use electrical or magnetic fields to accomplish this process. Bead-based microfluidic techniques offer an alternative approach that uses the bead’s solid surface to immobilize targets like particles or biological material. In this paper, we demonstrate a bead-based technique for exchanging droplet content by separating fluorescent microparticles in a microfluidic device. The device uses posts to filter surface-functionalized beads from a droplet and re-capture the filtered beads in a new droplet. With post spacing of 7 μm, beads above 10 μm had 100% capture efficiency. We demonstrate the efficacy of this system using targeted particles that bind onto the functionalized beads and are, therefore, transferred from one solution to another in the device. Binding capacity tests performed in the bulk phase showed an average binding capacity of 5 particles to each bead. The microfluidic device successfully separated the targeted particles from the non-targeted particles with up to 98% purity and 100% yield. PMID:28282412

Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haselhorst, Thomas; Muenster-Kuehnel, Anja K.; Oschlies, Melanie

2007-08-10

We report an easy and direct application of 'Saturation Transfer Double Difference' (STDD) NMR spectroscopy to identify ligands that bind to a Sepharose-immobilised target protein. The model protein, cytidine 5'-monophosphate sialic acid (CMP-Sia) synthetase, was expressed as a Strep-Tag II fusion protein and immobilised on Strep-Tactin Sepharose. STD NMR experiments of the protein-enriched Sepharose matrix in the presence of a binding ligand (cytidine 5'-triphosphate, CTP) and a non-binding ligand ({alpha}/{beta}-glucose) clearly show that CTP binds to the immobilised enzyme, whereas glucose has no affinity. This approach has three major advantages: (a) only low quantities of protein are required, (b) nomore » specialised NMR technology or the application of additional data analysis by non-routine methods is required, and (c) easy multiple use of the immobilised protein is available.« less

Lentiviral Protein Transfer Vectors Are an Efficient Vaccine Platform and Induce a Strong Antigen-Specific Cytotoxic T Cell Response

PubMed Central

Uhlig, Katharina M.; Schülke, Stefan; Scheuplein, Vivian A. M.; Malczyk, Anna H.; Reusch, Johannes; Kugelmann, Stefanie; Muth, Anke; Koch, Vivian; Hutzler, Stefan; Bodmer, Bianca S.; Schambach, Axel; Buchholz, Christian J.; Waibler, Zoe; Scheurer, Stephan

2015-01-01

ABSTRACT To induce and trigger innate and adaptive immune responses, antigen-presenting cells (APCs) take up and process antigens. Retroviral particles are capable of transferring not only genetic information but also foreign cargo proteins when they are genetically fused to viral structural proteins. Here, we demonstrate the capacity of lentiviral protein transfer vectors (PTVs) for targeted antigen transfer directly into APCs and thereby induction of cytotoxic T cell responses. Targeting of lentiviral PTVs to APCs can be achieved analogously to gene transfer vectors by pseudotyping the particles with truncated wild-type measles virus (MV) glycoproteins (GPs), which use human SLAM (signaling lymphocyte activation molecule) as a main entry receptor. SLAM is expressed on stimulated lymphocytes and APCs, including dendritic cells. SLAM-targeted PTVs transferred the reporter protein green fluorescent protein (GFP) or Cre recombinase with strict receptor specificity into SLAM-expressing CHO and B cell lines, in contrast to broadly transducing vesicular stomatitis virus G protein (VSV-G) pseudotyped PTVs. Primary myeloid dendritic cells (mDCs) incubated with targeted or nontargeted ovalbumin (Ova)-transferring PTVs stimulated Ova-specific T lymphocytes, especially CD8+ T cells. Administration of Ova-PTVs into SLAM-transgenic and control mice confirmed the observed predominant induction of antigen-specific CD8+ T cells and demonstrated the capacity of protein transfer vectors as suitable vaccines for the induction of antigen-specific immune responses. IMPORTANCE This study demonstrates the specificity and efficacy of antigen transfer by SLAM-targeted and nontargeted lentiviral protein transfer vectors into antigen-presenting cells to trigger antigen-specific immune responses in vitro and in vivo. The observed predominant activation of antigen-specific CD8+ T cells indicates the suitability of SLAM-targeted and also nontargeted PTVs as a vaccine for the induction of cytotoxic immune responses. Since cytotoxic CD8+ T lymphocytes are a mainstay of antitumoral immune responses, PTVs could be engineered for the transfer of specific tumor antigens provoking tailored antitumoral immunity. Therefore, PTVs can be used as safe and efficient alternatives to gene transfer vectors or live attenuated replicating vector platforms, avoiding genotoxicity or general toxicity in highly immunocompromised patients, respectively. Thereby, the potential for easy envelope exchange allows the circumventing of neutralizing antibodies, e.g., during repeated boost immunizations. PMID:26085166

The challenge of technology transfer: Buying in without selling out

PubMed Central

Pennypacker, H. S.

1986-01-01

Highly effective technologies flowing from the discipline of behavior analysis have not been widely adopted, thus threatening the survival of the discipline itself. An analysis of the contingencies underlying successful technology transfer suggests the need for direct, empirical involvement in the marketplace in order to insure that the maximum demonstrable benefits reach the ultimate users. A successful example of this strategy of technology transfer is provided. Three areas of intense national concern—urban violence, illiteracy, and declining industrial productivity—provide immediate opportunities for the technologies of behavior analysis to secure the place of the discipline in the intellectual mosaic of the 21st century. PMID:22478656

MORE THAN MONEY: THE EXPONENTIAL IMPACT OF ACADEMIC TECHNOLOGY TRANSFER.

PubMed

McDevitt, Valerie Landrio; Mendez-Hinds, Joelle; Winwood, David; Nijhawan, Vinit; Sherer, Todd; Ritter, John F; Sanberg, Paul R

2014-11-01

Academic technology transfer in its current form began with the passage of the Bayh-Dole Act in 1980, which allowed universities to retain ownership of federally funded intellectual property. Since that time, a profession has evolved that has transformed how inventions arising in universities are treated, resulting in significant impact to US society. While there have been a number of articles highlighting benefits of technology transfer, now, more than at any other time since the Bayh-Dole Act was passed, the profession and the impacts of this groundbreaking legislation have come under intense scrutiny. This article serves as an examination of the many positive benefits and evolution, both financial and intrinsic, provided by academic invention and technology transfer, summarized in Table 1.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McAchran, G.E.

The author first addresses the impediments to successful technology transfer, e.g., tax programs, planning horizons, and capital availability. He emphasizes that written information emanating from universities and national laboratories, in and of itself, is usually insufficient to insure technology transfer. He notes that most information is transferred through informal channels and, most effectively, through personal contacts. Noting that Monsanto was a founding member and remains active in they Council on Chemical Research and Technology Transfer Conferences, Inc., he cites examples of their activities in the past 15 years. While geographic proximity is an important factor, usually, Monsanto's 5-year program withmore » Oxford Univ., UK, is funded at approximately $2 million; Monsanto scientists are located at Oxford to facilitate the work and bring the technology back home. 7 references« less

MORE THAN MONEY: THE EXPONENTIAL IMPACT OF ACADEMIC TECHNOLOGY TRANSFER

PubMed Central

McDevitt, Valerie Landrio; Mendez-Hinds, Joelle; Winwood, David; Nijhawan, Vinit; Sherer, Todd; Ritter, John F.; Sanberg, Paul R.

2014-01-01

Academic technology transfer in its current form began with the passage of the Bayh–Dole Act in 1980, which allowed universities to retain ownership of federally funded intellectual property. Since that time, a profession has evolved that has transformed how inventions arising in universities are treated, resulting in significant impact to US society. While there have been a number of articles highlighting benefits of technology transfer, now, more than at any other time since the Bayh–Dole Act was passed, the profession and the impacts of this groundbreaking legislation have come under intense scrutiny. This article serves as an examination of the many positive benefits and evolution, both financial and intrinsic, provided by academic invention and technology transfer, summarized in Table 1. PMID:25061505

Formal methods technology transfer: Some lessons learned

NASA Technical Reports Server (NTRS)

Hamilton, David

1992-01-01

IBM has a long history in the application of formal methods to software development and verification. There have been many successes in the development of methods, tools and training to support formal methods. And formal methods have been very successful on several projects. However, the use of formal methods has not been as widespread as hoped. This presentation summarizes several approaches that have been taken to encourage more widespread use of formal methods, and discusses the results so far. The basic problem is one of technology transfer, which is a very difficult problem. It is even more difficult for formal methods. General problems of technology transfer, especially the transfer of formal methods technology, are also discussed. Finally, some prospects for the future are mentioned.

Reproductive Medicine in Amphibians.

PubMed

Chai, Norin

2017-05-01

Reproduction of amphibians includes ovulation, spermiation, fertilization, oviposition, larval stage and development, and metamorphosis. A problem at any stage could lead to reproductive failure. To stimulate reproduction, environmental conditions must be arranged to simulate changes in natural habits. Reproductive life history is well documented in amphibians; a thorough knowledge of this subject will aid the practitioner in diagnosis and treatment. Technologies for artificial reproduction are developing rapidly, and some protocols may be transferable to privately kept or endangered species. Reproductive tract disorders are rarely described; no bacterial or viral diseases are known that specifically target the amphibian reproductive system. Copyright © 2016 Elsevier Inc. All rights reserved.

Molecular mechanisms and therapeutic targets in neuroblastoma.

PubMed

Johnsen, John Inge; Dyberg, Cecilia; Fransson, Susanne; Wickström, Malin

2018-05-01

Neuroblastoma is the most common extracranical tumor of childhood and the most deadly tumor of infancy. It is characterized by early age onset and high frequencies of metastatic disease but also the capacity to spontaneously regress. Despite intensive therapy, the survival for patients with high-risk neuroblastoma and those with recurrent or relapsed disease is low. Hence, there is an urgent need to develop new therapies for these patient groups. The molecular pathogenesis based on high-throughput omics technologies of neuroblastoma is beginning to be resolved which have given the opportunity to develop personalized therapies for high-risk patients. Here we discuss the potential of developing targeted therapies against aberrantly expressed molecules detected in sub-populations of neuroblastoma patients and how these selected targets can be drugged in order to overcome treatment resistance, improve survival and quality of life for these patients and also the possibilities to transfer preclinical research into clinical testing. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Low latency, high bandwidth data communications between compute nodes in a parallel computer

DOEpatents

Archer, Charles J.; Blocksome, Michael A.; Ratterman, Joseph D.; Smith, Brian E.

2010-11-02

Methods, parallel computers, and computer program products are disclosed for low latency, high bandwidth data communications between compute nodes in a parallel computer. Embodiments include receiving, by an origin direct memory access (`DMA`) engine of an origin compute node, data for transfer to a target compute node; sending, by the origin DMA engine of the origin compute node to a target DMA engine on the target compute node, a request to send (`RTS`) message; transferring, by the origin DMA engine, a predetermined portion of the data to the target compute node using memory FIFO operation; determining, by the origin DMA engine whether an acknowledgement of the RTS message has been received from the target DMA engine; if the an acknowledgement of the RTS message has not been received, transferring, by the origin DMA engine, another predetermined portion of the data to the target compute node using a memory FIFO operation; and if the acknowledgement of the RTS message has been received by the origin DMA engine, transferring, by the origin DMA engine, any remaining portion of the data to the target compute node using a direct put operation.

Technology Transfer: A Third World Perspective.

ERIC Educational Resources Information Center

Akubue, Anthony I.

2002-01-01

Technology transfer models are based on assumptions that do not reflect Third-World realities. Obstacles to building indigenous technology capacity include multinational corporations' control of innovations, strings attached to foreign aid, and indigenous reluctance to undertake research. Four areas of development include foreign direct…

Definition of technology development missions for early space station, orbit transfer vehicle servicing, volume 2

NASA Technical Reports Server (NTRS)

1983-01-01

Propellant transfer, storage, and reliquefaction TDM; docking and berthing technology development mission; maintenance technology development mission; OTV/payload integration, space station interface/accommodations; combined TDM conceptual design; programmatic analysis; and TDM equipment usage are discussed.

Ethical Considerations in Technology Transfer.

ERIC Educational Resources Information Center

Froehlich, Thomas J.

1991-01-01

Examines ethical considerations involved in the transfer of appropriate information technology to less developed countries. Approaches to technology are considered; two philosophical frameworks for studying ethical considerations are discussed, i.e., the Kantian approach and the utilitarian perspective by John Stuart Mill; and integration of the…

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2011 CFR

2011-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.3 Program description. (a) The Secretary, acting through the... for the Transfer of Manufacturing Technology. Each Center shall be affiliated with a U.S.-based...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.3 Program description. (a) The Secretary, acting through the... for the Transfer of Manufacturing Technology. Each Center shall be affiliated with a U.S.-based...

Commercial technologies from the SP-100 program

NASA Astrophysics Data System (ADS)

Truscello, Vincent C.; Fujita, Toshio; Mondt, Jack F.

1995-01-01

For more than a decade, the Jet Propulsion Labortory (JPL) and Los Alamos National Laboratory (LANL) have managed a multi-agency funded effort to develop a space reactor power system. This SP-100 Program has developed technologies required for space power systems that can be implemented in the industrial and commercial sectors to improve our competitiveness in the global economy. Initial steps taken to transfer this technology from the laboratories to industrial and commercial entities within the United States include: (1) identifying specific technologies having commercial potential; (2) distributing information describing the identified technologies and interacting with interested commercial and industrial entities to develop application-specific details and requirements; and (3) providing a technological data base that leads to transfer of technology or the forming of teaming arrangements to accomplish the transfer by tailoring the technology to meet application-specific requirements. SP-100 technologies having commercial potential encompass fabrication processes, devices, and components. Examples are a process for bonding refractory metals to graphite, a device to sense the position of an actuator and a component to enable rotating machines to operate without supplying lubrication ( a self-lubricating ball bearing). Shortly after the National Aeronautics and Space Administration (NASA) Regional Technology Transfer Centers widely disseminated information covering SP-100 technologies, over one hundred expressions of interest were received. These early responses indicate that there is a large potential benefit in transferring SP-100 technology. Interactions with industrial and commercial entities have identified a substantial need for creating teaming arrangements involving the interested entity and personnel from laboratories and their contractors, who have the knowledge and ability to tailor the technology to meet application-specific requirements.

Applications of aerospace technology

NASA Technical Reports Server (NTRS)

Rouse, Doris J.

1984-01-01

The objective of the Research Triangle Institute Technology Transfer Team is to assist NASA in achieving widespread utilization of aerospace technology in terrestrial applications. Widespread utilization implies that the application of NASA technology is to benefit a significant sector of the economy and population of the Nation. This objective is best attained by stimulating the introduction of new or improved commercially available devices incorporating aerospace technology. A methodology is presented for the team's activities as an active transfer agent linking NASA Field Centers, industry associations, user groups, and the medical community. This methodology is designed to: (1) identify priority technology requirements in industry and medicine, (2) identify applicable NASA technology that represents an opportunity for a successful solution and commercial product, (3) obtain the early participation of industry in the transfer process, and (4) successfully develop a new product based on NASA technology.

Secondary natural gas recovery: Targeted applications for infield reserve growth in midcontinent reservoirs, Boonsville Field, Fort Worth Basin, Texas. Topical report, May 1993--June 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardage, B.A.; Carr, D.L.; Finley, R.J.

1995-07-01

The objectives of this project are to define undrained or incompletely drained reservoir compartments controlled primarily by depositional heterogeneity in a low-accommodation, cratonic Midcontinent depositional setting, and, afterwards, to develop and transfer to producers strategies for infield reserve growth of natural gas. Integrated geologic, geophysical, reservoir engineering, and petrophysical evaluations are described in complex difficult-to-characterize fluvial and deltaic reservoirs in Boonsville (Bend Conglomerate Gas) field, a large, mature gas field located in the Fort Worth Basin of North Texas. The purpose of this project is to demonstrate approaches to overcoming the reservoir complexity, targeting the gas resource, and doing somore » using state-of-the-art technologies being applied by a large cross section of Midcontinent operators.« less

The evolution of signalling from ISDN to B-ISDN

NASA Astrophysics Data System (ADS)

Niemegeers, I. G.; Heijenk, G. J.

1992-04-01

Issues in B-ISDN (Broadband-Integrated Services Digital Network) signaling are clarified and directions for solutions are discussed. Signaling is one of the key elements in the provision of services by modern telecommunication systems. Where the introduction of ISDN can still be regarded as a straightforward evolution from the world of telephony, B-ISDN, represents a radical departure. The scope of the services to be offered in the target B-ISDN is much wider, and the underlying technology, such as ATM (Asynchronous Transfer Mode), is vastly different. This results in requirements for signaling which cannot be met by the present systems such as SS7 (common channel Signaling System) and DSS1 (Digital Subscriber Signaling). The new requirements are examined and some of the directions presently being investigated for supporting the target B-ISDN are analyzed.

Technology Transfer: Creating the Right Environment.

ERIC Educational Resources Information Center

McCullough, John M.

2003-01-01

Small and medium-sized enterprises are considered to be the backbone of many European economies and a catalyst for economic growth. Universities are key players in encouraging and supporting economic growth through technology and knowledge-related transfer. The right environment to foster transfer is a proactive culture. (Contains 22 references.)…

40 CFR 63.126 - Transfer operations provisions-reference control technology.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Wastewater § 63.126 Transfer operations provisions—reference control technology. (a) For each Group 1... control device. (1) Each vapor collection system shall be designed and operated to collect the organic... process, fuel gas system, or control device shall be operating. (b) For each Group 1 transfer rack the...

Definition of technology development missions for early space station, orbit transfer vehicle servicing. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1983-01-01

Orbital Transfer Vehicle (OTV) servicing study scope, propellant transfer, storage and reliquefaction technology development missions (TDM), docking and berthing TDM, maintenance TDM, OTV/payload integration TDM, combined TDMS design, summary space station accomodations, programmatic analysis, and TDM equipment operational usage are discussed.

76 FR 11498 - Submission for OMB Review; Comment Request; Generic Submission of Technology Transfer Center (TTC...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

...; Comment Request; Generic Submission of Technology Transfer Center (TTC) External Customer Satisfaction... Transfer Center (TTC) External Customer Satisfaction Surveys (NCI). Type of Information Collection Request... information on the satisfaction of TTC's external customers with TTC customer services; collect information of...

76 FR 67153 - Federal Acquisition Regulation; Submission for OMB Review; Payment by Electronic Fund Transfer

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-31

...; Submission for OMB Review; Payment by Electronic Fund Transfer AGENCY: Department of Defense (DOD), General... collection requirement concerning payment by electronic fund transfer. A notice was published in the Federal... technological collection techniques or other forms of information technology. DATES: Submit comments on or...

Spinoff 1995

NASA Technical Reports Server (NTRS)

Haggerty, James J.

1995-01-01

Recognizing the great potential of the technology bank, Congress charged NASA with stimulating the widest possible use of this valuable resource in the national interest. NASA's instrument of that purpose is the Technology Transfer Program, which seeks to broaden and accelerate the spinoff process. Its intent is to spur expanded national benefit, in terms of new products and new jobs, by facilitating the commercial application of the technology; it encourages greater use of the storehouse of knowledge by providing a channel linking the technology and those who might be able to put it to advantageous use. In July 1994, NASA implemented an Agenda for Change - a new way of doing business in partnership with the private sector. This Agenda marks the beginning of a new focus to further improve our contributions to America's economic security through the pursuit of aeronautics and space missions. This publication is an implement of the Technology Transfer Program intended to heighten awareness among potential users of the technology available for transfer and the economic and social benefits that might be realized by applications of NASA technology to US commercial interests. Spinoff 1995 is organized in three sections. Section 1 outlines NASA's mainline effort, the major programs that generate new technology and therefore replenish and expand the bank of technical knowledge available for application. Section 2, the focal point of this volume, contains a representative sampling of spinoff products and processes that resulted from applications of technology originally developed to meet NASA aerospace goals. Section 3, describes the various mechanisms NASA employs to stimulate technology transfer and lists, in an appendix, contact sources for further information about the Technology Transfer Program.

Double-layered cell transfer technology for bone regeneration

PubMed Central

Akazawa, Keiko; Iwasaki, Kengo; Nagata, Mizuki; Yokoyama, Naoki; Ayame, Hirohito; Yamaki, Kazumasa; Tanaka, Yuichi; Honda, Izumi; Morioka, Chikako; Kimura, Tsuyoshi; Komaki, Motohiro; Kishida, Akio; Izumi, Yuichi; Morita, Ikuo

2016-01-01

For cell-based medicine, to mimic in vivo cellular localization, various tissue engineering approaches have been studied to obtain a desirable arrangement of cells on scaffold materials. We have developed a novel method of cell manipulation called “cell transfer technology”, enabling the transfer of cultured cells onto scaffold materials, and controlling cell topology. Here we show that using this technique, two different cell types can be transferred onto a scaffold surface as stable double layers or in patterned arrangements. Various combinations of adherent cells were transferred to a scaffold, amniotic membrane, in overlapping bilayers (double-layered cell transfer), and transferred cells showed stability upon deformations of the material including folding and trimming. Transplantation of mesenchymal stem cells from periodontal ligaments (PDLSC) and osteoblasts, using double-layered cell transfer significantly enhanced bone formation, when compared to single cell type transplantation. Our findings suggest that this double-layer cell transfer is useful to produce a cell transplantation material that can bear two cell layers. Moreover, the transplantation of an amniotic membrane with PDLSCs/osteoblasts by cell transfer technology has therapeutic potential for bone defects. We conclude that cell transfer technology provides a novel and unique cell transplantation method for bone regeneration. PMID:27624174

KSC-2013-3576

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Bob Cabana, director of NASA's Kennedy Space Center in Florida, discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

KSC-2013-3571

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Bob Cabana, director of NASA's Kennedy Space Center in Florida, discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

KSC-2013-3568

NASA Image and Video Library

2013-09-12

CAPE CANAVERAL, Fla. – Karen Thompson, chief technologist at NASA's Kennedy Space Center in Florida, discusses technology transfer with attendees at the Technology Transfer Forum of the Economic Development Commission of Florida's Space Coast. A goal of the session was to showcase ways commercial businesses can work with NASA to develop technology and apply existing technology to commercial uses. Photo credit: NASA/Glenn Benson

EPA's Technology Transfer: Now Geared to Industry

ERIC Educational Resources Information Center

Environmental Science and Technology, 1973

1973-01-01

Through capsule reports, seminars, and design manuals, Environmental Protection Agency has activated its industrial technology transfer program for marketing the products of federal research, development, and demonstration activities. Its purpose is to disseminate information to industry on available technology for control and treatment of air,…

Facilitation of University Technology Transfer Through a Cooperative Service-University-Industry Program.

DTIC Science & Technology

1997-02-01

through technology transfer centers for applied engineering training and consulting, and second, in assisting and expanding university technology...both the services and industry with an applied engineering program and the training for new engineers and researchers, (2) serve as an information

University Technology Transfer Factors as Predictors of Entrepreneurial Orientation

ERIC Educational Resources Information Center

Kirkman, Dorothy M.

2011-01-01

University technology transfer is a collaborative effort between academia and industry involving knowledge sharing and learning. Working closely with their university partners affords biotechnology firms the opportunity to successfully develop licensed inventions and gain access to novel scientific and technological discoveries. These factors may…

15 CFR 290.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER... efficiency. (b) The term Center or Regional Center means a NIST-established Regional Center for the Transfer... Standards and Technology. (e) The term NIST means the National Institute of Standards and Technology, U.S...

15 CFR 290.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER... efficiency. (b) The term Center or Regional Center means a NIST-established Regional Center for the Transfer... Standards and Technology. (e) The term NIST means the National Institute of Standards and Technology, U.S...

15 CFR 290.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER... efficiency. (b) The term Center or Regional Center means a NIST-established Regional Center for the Transfer... Standards and Technology. (e) The term NIST means the National Institute of Standards and Technology, U.S...

15 CFR 290.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER... efficiency. (b) The term Center or Regional Center means a NIST-established Regional Center for the Transfer... Standards and Technology. (e) The term NIST means the National Institute of Standards and Technology, U.S...

15 CFR 290.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER... efficiency. (b) The term Center or Regional Center means a NIST-established Regional Center for the Transfer... Standards and Technology. (e) The term NIST means the National Institute of Standards and Technology, U.S...

Smart systems and personalized health: the real challenge of bridging the innovation gap.

PubMed

Lymberis, Andreas

2014-01-01

Smart miniaturized systems, emerging from the integration of heterogeneous technologies like micro- and nano electronics, photonics, biotechnology, materials and information & communication technologies are considered today, after two decades of intensive public support, proven concepts and functional prototypes, as key enablers opening up new opportunities for healthcare and in particular personalized health. They offer an enhanced ability to sense, detect, analyze, communicate, respond, and monitor phenomena from macro (e.g. body, tissues) to nano scale (e.g. molecules, genes). For the majority of these projects, planning for the next phase of prototype validation, product design, supply chain, user targeting, clinical validation and commercial roll-out are now taking full attention. The new EU Framework Program for Research and Innovation, Horizon 2020, is focusing on technology transfer support and building ecosystems and value chains to ensure better time to market and higher impact of knowledge-based technologies. The state-of-the-art and upcoming challenges for the implementation of H2020 and new opportunities in smart systems for pHealth are discussed in the paper.

The uses of cognitive training technologies in the treatment of autism spectrum disorders.

PubMed

Wass, Sam V; Porayska-Pomsta, Kaska

2014-11-01

In this review, we focus on research that has used technology to provide cognitive training - i.e. to improve performance on some measurable aspect of behaviour - in individuals with autism spectrum disorders. We review technology-enhanced interventions that target three different cognitive domains: (a) emotion and face recognition, (b) language and literacy, and (c) social skills. The interventions reviewed allow for interaction through different modes, including point-and-click and eye-gaze contingent software, and are delivered through diverse implementations, including virtual reality and robotics. In each case, we examine the evidence of the degree of post-training improvement observed following the intervention, including evidence of transfer to altered behaviour in ecologically valid contexts. We conclude that a number of technological interventions have found that observed improvements within the computerised training paradigm fail to generalise to altered behaviour in more naturalistic settings, which may result from problems that people with autism spectrum disorders experience in generalising and extrapolating knowledge. However, we also point to several promising findings in this area. We discuss possible directions for future work. © The Author(s) 2013.

Technology transfer and evaluation for Space Station telerobotics

NASA Technical Reports Server (NTRS)

Price, Charles R.; Stokes, Lebarian; Diftler, Myron A.

1994-01-01

The international space station (SS) must take advantage of advanced telerobotics in order to maximize productivity and safety and to reduce maintenance costs. The Automation and Robotics Division at the NASA Lyndon B. Johnson Space Center (JSC) has designed, developed, and constructed the Automated Robotics Maintenance of Space Station (ARMSS) facility for the purpose of transferring and evaluating robotic technology that will reduce SS operation costs. Additionally, JSC had developed a process for expediting the transfer of technology from NASA research centers and evaluating these technologies in SS applications. Software and hardware system developed at the research centers and NASA sponsored universities are currently being transferred to JSC and integrated into the ARMSS for flight crew personnel testing. These technologies will be assessed relative to the SS baseline, and, after refinements, those technologies that provide significant performance improvements will be recommended as upgrades to the SS. Proximity sensors, vision algorithms, and manipulator controllers are among the systems scheduled for evaluation.

Development of Technology Transfer Economic Growth Metrics

NASA Technical Reports Server (NTRS)

Mastrangelo, Christina M.

1998-01-01

The primary objective of this project is to determine the feasibility of producing technology transfer metrics that answer the question: Do NASA/MSFC technical assistance activities impact economic growth? The data for this project resides in a 7800-record database maintained by Tec-Masters, Incorporated. The technology assistance data results from survey responses from companies and individuals who have interacted with NASA via a Technology Transfer Agreement, or TTA. The goal of this project was to determine if the existing data could provide indications of increased wealth. This work demonstrates that there is evidence that companies that used NASA technology transfer have a higher job growth rate than the rest of the economy. It also shows that the jobs being supported are jobs in higher wage SIC codes, and this indicates improvements in personal wealth. Finally, this work suggests that with correct data, the wealth issue may be addressed.

Cost benefit assessment of NASA remote sensing technology transferred to the State of Georgia

NASA Technical Reports Server (NTRS)

Kelly, D. L.; Zimmer, R. P.; Wilkins, R. D.

1978-01-01

The benefits involved in the transfer of NASA remote sensing technology to eight Georgia state agencies are identified in quantifiable and qualitative terms, and a value for these benefits is computed by means of an effectiveness analysis. The benefits of the transfer are evaluated by contrasting a baseline scenario without Landsat and an alternative scenario with Landsat. The net present value of the Landsat technology being transferred is estimated at 9.5 million dollars. The estimated value of the transfer is most sensitive to discount rate, the cost of photo acquisition, and the cost of data digitalization. It is estimated that, if the budget is constrained, Landsat could provide data products roughly seven times more frequently than would otherwise be possible.

Incorporating the Delphi Technique to investigate renewable energy technology transfer in Saudi Arabia

NASA Astrophysics Data System (ADS)

Al-Otaibi, Nasir K.

Saudi Arabia is a major oil-producing nation facing a rapidly-growing population, high unemployment, climate change, and the depletion of its natural resources, potentially including its oil supply. Technology transfer is regarded as a means to diversify countries' economies beyond their natural resources. This dissertation examined the opportunities and barriers to utilizing technology transfer successfully to build renewable energy resources in Saudi Arabia to diversify the economy beyond oil production. Examples of other developing countries that have successfully used technology transfer to transform their economies are explored, including Japan, Malayasia, and the United Arab Emirates. Brazil is presented as a detailed case study to illustrate its transition to an economy based to a much greater degree than before on renewable energy. Following a pilot study, the Delphi Method was used in this research to gather the opinions of a panel of technology transfer experts consisting of 10 heterogeneous members of different institutions in the Kingdom of Saudi Arabia, including aviation, telecommunication, oil industry, education, health systems, and military and governmental organizations. In three rounds of questioning, the experts identified Education, Dependence on Oil, and Manpower as the 3 most significant factors influencing the potential for success of renewable energy technology transfer for Saudi Arabia. Political factors were also rated toward the "Very Important" end of a Likert scale and were discussed as they impact Education, Oil Dependence, and Manpower. The experts' opinions are presented and interpreted. They form the basis for recommended future research and discussion of how in light of its political system and its dependence on oil, Saudi Arabia can realistically move forward on renewable energy technology transfer and secure its economic future.

Using virtual reality to improve walking post-stroke: translation to individuals with diabetes.

PubMed

Deutsch, Judith E

2011-03-01

Use of virtual reality (VR) technology to improve walking for people post-stroke has been studied for its clinical application since 2004. The hardware and software used to create these systems has varied but has predominantly been constituted by projected environments with users walking on treadmills. Transfer of training from the virtual environment to real-world walking has modest but positive research support. Translation of the research findings to clinical practice has been hampered by commercial availability and costs of the VR systems. Suggestions for how the work for individuals post-stroke might be applied and adapted for individuals with diabetes and other impaired ambulatory conditions include involvement of the target user groups (both practitioners and clients) early in the design and integration of activity and education into the systems. © 2011 Diabetes Technology Society.

Guidance and control strategies for aerospace vehicles

NASA Technical Reports Server (NTRS)

Naidu, Desineni S.; Hibey, Joseph L.

1989-01-01

The optimal control problem arising in coplanar orbital transfer employing aeroassist technology and the fuel-optimal control problem arising in orbital transfer vehicles employing aeroassist technology are addressed.

Bitsy Thinks Big

NASA Technical Reports Server (NTRS)

2001-01-01

AeroAstro, of Herndon, Virginia, developed a nanospacecraft core module capable of developing recyclable spacecraft designs using standard interfaces. From this core module, known as the Bitsy(TM) kernel, custom spacecraft are able to connect mission-specific instruments and subsystems for variation in mission usage. The nanospacecraft core module may be used in conjunction with an existing microsatellite bus or customized to meet specific requirements. Building on this premise, AeroAstro has developed a line of satellite communications equipment, sun sensors, and Lithium-Ion batteries which are all incorporated in its complete line of mission-specific nanospacecraft. The Bitsy technology is also a key component in AeroAstro#s satellite inspection products and orbital transfer services. In the future, AeroAstro plans to market an even less expensive version of the Bitsy technology. The plan, which is targeted to universities, markets a sort of "satellite in a kit," for less than $1 million. This technology would allow universities to build true space hardware for a fraction of the cost of launching a regular satellite.

Precision and manufacturing at the Lawrence Livermore National Laboratory

NASA Technical Reports Server (NTRS)

Saito, Theodore T.; Wasley, Richard J.; Stowers, Irving F.; Donaldson, Robert R.; Thompson, Daniel C.

1994-01-01

Precision Engineering is one of the Lawrence Livermore National Laboratory's core strengths. This paper discusses the past and present current technology transfer efforts of LLNL's Precision Engineering program and the Livermore Center for Advanced Manufacturing and Productivity (LCAMP). More than a year ago the Precision Machine Commercialization project embodied several successful methods of transferring high technology from the National Laboratories to industry. Currently, LCAMP has already demonstrated successful technology transfer and is involved in a broad spectrum of current programs. In addition, this paper discusses other technologies ripe for future transition including the Large Optics Diamond Turning Machine.

Applications of aerospace technology in industry, a technology transfer profile: Contamination control

NASA Technical Reports Server (NTRS)

1971-01-01

The strong influence NASA-sponsored research has had on the development of solutions to difficult contamination problems is considered. The contamination control field is comprised of an industrial base, supplying the tools of control; a user base, adopting control techniques; and a technical base, expanding the concepts of control. Both formal and informal mechanisms used by NASA to communicate a variety of technical advances are reviewed and certain examples of the expansion of the user base through technology transfer are given. Issues related to transfer of NASA-generated contamination control technology are emphasized.

Precision and manufacturing at the Lawrence Livermore National Laboratory

NASA Astrophysics Data System (ADS)

Saito, Theodore T.; Wasley, Richard J.; Stowers, Irving F.; Donaldson, Robert R.; Thompson, Daniel C.

1994-02-01

Precision Engineering is one of the Lawrence Livermore National Laboratory's core strengths. This paper discusses the past and present current technology transfer efforts of LLNL's Precision Engineering program and the Livermore Center for Advanced Manufacturing and Productivity (LCAMP). More than a year ago the Precision Machine Commercialization project embodied several successful methods of transferring high technology from the National Laboratories to industry. Currently, LCAMP has already demonstrated successful technology transfer and is involved in a broad spectrum of current programs. In addition, this paper discusses other technologies ripe for future transition including the Large Optics Diamond Turning Machine.

Technology transfer in the NASA Ames Advanced Life Support Division

NASA Technical Reports Server (NTRS)

Connell, Kathleen; Schlater, Nelson; Bilardo, Vincent; Masson, Paul

1992-01-01

This paper summarizes a representative set of technology transfer activities which are currently underway in the Advanced Life Support Division of the Ames Research Center. Five specific NASA-funded research or technology development projects are synopsized that are resulting in transfer of technology in one or more of four main 'arenas:' (1) intra-NASA, (2) intra-Federal, (3) NASA - aerospace industry, and (4) aerospace industry - broader economy. Each project is summarized as a case history, specific issues are identified, and recommendations are formulated based on the lessons learned as a result of each project.

Enhancing SERS by Means of Supramolecular Charge Transfer

NASA Technical Reports Server (NTRS)

Wong, Eric; Flood, Amar; Morales, Alfredo

2009-01-01

In a proposed method of sensing small quantities of molecules of interest, surface enhanced Raman scattering (SERS) spectroscopy would be further enhanced by means of intermolecular or supramolecular charge transfer. There is a very large potential market for sensors based on this method for rapid detection of chemical and biological hazards. In SERS, the Raman signals (vibrational spectra) of target molecules become enhanced by factors of the order of 108 when those molecules are in the vicinities of nanostructured substrate surfaces that have been engineered to have plasmon resonances that enhance local electric fields. SERS, as reported in several prior NASA Tech Briefs articles and elsewhere, has remained a research tool and has not yet been developed into a practical technique for sensing of target molecules: this is because the short range (5 to 20 nm) of the field enhancement necessitates engineering of receptor molecules to attract target molecules to the nanostructured substrate surfaces and to enable reliable identification of the target molecules in the presence of interferants. Intermolecular charge-transfer complexes have been used in fluorescence-, photoluminescence-, and electrochemistry-based techniques for sensing target molecules, but, until now, have not been considered for use in SERS-based sensing. The basic idea of the proposed method is to engineer receptor molecules that would be attached to nanostructured SERS substrates and that would interact with the target molecules to form receptor-target supramolecular charge-transfer complexes wherein the charge transfer could be photoexcited.

a Comparison of Two Strategies for Avoiding Negative Transfer in Domain Adaptation Based on Logistic Regression

NASA Astrophysics Data System (ADS)

Paul, A.; Vogt, K.; Rottensteiner, F.; Ostermann, J.; Heipke, C.

2018-05-01

In this paper we deal with the problem of measuring the similarity between training and tests datasets in the context of transfer learning (TL) for image classification. TL tries to transfer knowledge from a source domain, where labelled training samples are abundant but the data may follow a different distribution, to a target domain, where labelled training samples are scarce or even unavailable, assuming that the domains are related. Thus, the requirements w.r.t. the availability of labelled training samples in the target domain are reduced. In particular, if no labelled target data are available, it is inherently difficult to find a robust measure of relatedness between the source and target domains. This is of crucial importance for the performance of TL, because the knowledge transfer between unrelated data may lead to negative transfer, i.e. to a decrease of classification performance after transfer. We address the problem of measuring the relatedness between source and target datasets and investigate three different strategies to predict and, consequently, to avoid negative transfer in this paper. The first strategy is based on circular validation. The second strategy relies on the Maximum Mean Discrepancy (MMD) similarity metric, whereas the third one is an extension of MMD which incorporates the knowledge about the class labels in the source domain. Our method is evaluated using two different benchmark datasets. The experiments highlight the strengths and weaknesses of the investigated methods. We also show that it is possible to reduce the amount of negative transfer using these strategies for a TL method and to generate a consistent performance improvement over the whole dataset.

NASA spinoffs to public service

NASA Technical Reports Server (NTRS)

Ault, L. A.; Cleland, J. G.

1989-01-01

The National Aeronautics and Space Administration (NASA) Technology Utilization (TU) Division of the Office of Commercial Programs has been quite successful in directing the transfer to technology into the public sector. NASA developments of particular interest have been those in the areas of aerodynamics and aviation transport, safety, sensors, electronics and computing, and satellites and remote sensing. NASA technology has helped law enforcement, firefighting, public transportation, education, search and rescue, and practically every other sector of activity serving the U.S. public. NASA works closely with public service agencies and associations, especially those serving local needs of citizens, to expedite technology transfer benefits. A number of examples exist to demonstrate the technology transfer method and opportunities of NASA spinoffs to public service.

Industrial benefits and future expectations in materials and processes resulting from space technology

NASA Technical Reports Server (NTRS)

Meyer, J. D.

1977-01-01

Space technology transfer is discussed as applied to the field of materials science. Advances made in processing include improved computer techniques, and structural analysis. Technology transfer is shown to have an important impact potential in the overall productivity of the United States.

Technology utilization and American competitiveness

NASA Astrophysics Data System (ADS)

Penaranda, Frank; Arnold, Ray; Fetterolf, Fred

This session of discussions reports on two sides of the technology transfer issue. The speakers are representatives of the aluminum industry (Alcoa Aluminum) and the National Aeronautics and Space Administration, Office of Commercial Programs. They discuss what technology transfer means, what NASA does for industry, and how information is disseminated.

Technology utilization and American competitiveness

NASA Technical Reports Server (NTRS)

Penaranda, Frank; Arnold, Ray; Fetterolf, Fred

1992-01-01

This session of discussions reports on two sides of the technology transfer issue. The speakers are representatives of the aluminum industry (Alcoa Aluminum) and the National Aeronautics and Space Administration, Office of Commercial Programs. They discuss what technology transfer means, what NASA does for industry, and how information is disseminated.

76 FR 71562 - Emergint Technologies, Inc.; Transfer of Data

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038: FRL-9326-9] Emergint Technologies, Inc... Cosmetic Act (FFDCA), including information that may have been claimed as Confidential Business Information (CBI) by the submitter, will be transferred to Emergint Technologies, Inc. in accordance with 40 CFR 2...

Facilitation of University Technology Transfer through a Cooperative Army-University-Industry Program,

DTIC Science & Technology

1995-01-01

through Army technology transfer centers for applied engineering training and consulting, and second in assisting and expanding university technology...industry with an applied engineering program and the training for new engineers and researchers, serve as an information resource for both the Army and

University-Industry Entrepreneurship: The Organization and Management of American University Technology Transfer Units.

ERIC Educational Resources Information Center

Dill, David D.

1995-01-01

A survey of 289 university technology transfer units investigated their organization, management, and perceived performance effectiveness. Unit types studied included licensing and patent offices, small business development centers, research and technology centers, business facility incubators, and entrepreneurial investment/endowment offices.…

AFRL Materials and Manufacturing Directorate

Science.gov Websites

Laboratory Air Force Installation Contracting Agency Air Force Institute of Technology National Air & Vehicles (RV) Technology Transfer (T2) 711th Human Performance Wing (711 HPW) Airman Systems (RH) Human Interest AF Small Business Innovation Research/Small Business Technology Transfer (SBIR / STTR) AFRL

75 FR 18826 - Notice of Inventions Available for License

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

..., Office of the Assistant General Counsel for Technology Transfer and Intellectual Property, U.S..., 2010. Paul A. Gottlieb, Assistant General Counsel for Technology, Transfer and Intellectual Property...

Blending addiction research and practice: strategies for technology transfer.

PubMed

Condon, Timothy P; Miner, Lucinda L; Balmer, Curtis W; Pintello, Denise

2008-09-01

Consistent with traditional conceptions of technology transfer, efforts to translate substance abuse and addiction research into treatment practice have typically relied on the passive dissemination of research findings. The large gap between addiction research and practice, however, indicates that there are many barriers to successful technology transfer and that dissemination alone is not sufficient to produce lasting changes in addiction treatment. To accelerate the translation of research into practice, the National Institute on Drug Abuse launched the Blending Initiative in 2001. In part a collaboration with the Substance Abuse and Mental Health Services Administration/Center for Substance Abuse Treatment's Addiction Technology Transfer Center program, this initiative aims to improve the development, effectiveness, and usability of evidence-based practices and reduce the obstacles to their timely adoption and implementation.

An analysis of successful commercialization of federally funded R&D energy technologies

NASA Astrophysics Data System (ADS)

Asuquo, Gibson Esang

Several studies indicate that commercialization of federally funded R&D technologies to private sector remains low. In an extension of research demonstrating relative effectiveness of various technology-transfer mechanisms used by the Department of Energy (DOE) in transferring federally funded R&D technologies, this study quantitatively analyzed 52 Industrial Technology Program (ITP) funded R&D technologies, from 1993 through 2006, to understand commercialization success of DOE's funded R&D technologies, based on the correlative significance between independent variables (R&D durations and levels of funding) and dependent variable (technology commercialization output). No statistically significant linear relationship was found between the studied variables. The R2 (the coefficient of multiple determination) value indicates that only three percent (0.03) of the change in the output of commercialized technologies can be explained by the change in the two independent variables. The results of this study have led to an important conclusion that the research, development, and deployment (RD&D) of federally funded energy technologies is complex and a non-linear process. The problem requires a consideration of other factors and a research design that can accommodate the complexity involved. However, as determined by this study, the ITP technology commercialization output (success rate) of 22% is nearly two times as high as the 14% Booz-Allen estimate for the rest of U.S. industry. A quantitative research (such as this study) that attempts to understand the relative significance of correlational relationship between R&D variables appears to offer insufficient explanations as to why the federal government is not getting high technology commercialization output from its dollar investments in R&D. Some qualitative research approaches could move this important research to the next level in the future. Further research in this area should focus on causal effects between R&D variables. The study should attempt to identify the effect that could be caused by an early involvement of angel investors, venture capitalists, and end-users of technologies during RD&D. Successful commercialization of energy technologies requires targeting the most promising innovations that may be jointly supported by public and private sector. A few suggestions on how to improve commercialization of federally funded R&D are outlined in Section 10.3 of this study.

Task-Technology Fit Assessment of an Expertise Transfer System

DTIC Science & Technology

2009-03-01

Air Education and Training Command In Partial Fulfillment of the Requirements for the Degree of Master of Science in Information Resource Management...Transfer Forum (ETF) developed by the Oklahoma State University for the Defense Ammunition Center’s quality assurance personnel. The preliminary findings...Technology-to-Performance Chain (TPC) ....................................................................13 Expertise Transfer Forum (ETF

"Kaizen" and Technology Transfer Instructors as Work-based Learning Facilitators in Overseas Transplants: A Case Study.

ERIC Educational Resources Information Center

Elsey, Barry; Fujiwara, Asahi

2000-01-01

A study of 240 instructors of kaizen (continuous quality improvement) and technology transfer in overseas assignments for Toyota found that commitment to work and corporate cultural values were significant. Instructors recognized the responsibility and challenges of communicating and transferring their know-how across cultures. (SK)

Technology transfer and other public policy implications of multi-national arrangements for the production of commercial airframes

NASA Technical Reports Server (NTRS)

Gellman, A. J.; Price, J. P.

1978-01-01

A study to examine the question of technology transfer through international arrangements for production of commercial transport aircraft is presented. The likelihood of such transfer under various representative conditions was determined and an understanding of the economic motivations for, effects of, joint venture arrangements was developed. Relevant public policy implications were also assessed. Multinational consortia with U.S. participation were focused upon because they generate the full range of pertinent public issues (including especially technology transfer), and also because of recognized trends toward such arrangements. An extensive search and analysis of existing literature to identify the key issues, and in-person interviews with executives of U.S. and European commercial airframe producers was reviewed. Distinctions were drawn among product-embodied, process, and management technologies in terms of their relative possibilities of transfer and the significance of such transfer. Also included are observations on related issues such as the implications of U.S. antitrust policy with respect to the formation of consortia and the competitive viability of the U.S. aircraft manufacturing industry.

Gene doping detection: evaluation of approach for direct detection of gene transfer using erythropoietin as a model system.

PubMed

Baoutina, A; Coldham, T; Bains, G S; Emslie, K R

2010-08-01

As clinical gene therapy has progressed toward realizing its potential, concern over misuse of the technology to enhance performance in athletes is growing. Although 'gene doping' is banned by the World Anti-Doping Agency, its detection remains a major challenge. In this study, we developed a methodology for direct detection of the transferred genetic material and evaluated its feasibility for gene doping detection in blood samples from athletes. Using erythropoietin (EPO) as a model gene and a simple in vitro system, we developed real-time PCR assays that target sequences within the transgene complementary DNA corresponding to exon/exon junctions. As these junctions are absent in the endogenous gene due to their interruption by introns, the approach allows detection of trace amounts of a transgene in a large background of the endogenous gene. Two developed assays and one commercial gene expression assay for EPO were validated. On the basis of ability of these assays to selectively amplify transgenic DNA and analysis of literature on testing of gene transfer in preclinical and clinical gene therapy, it is concluded that the developed approach would potentially be suitable to detect gene doping through gene transfer by analysis of small volumes of blood using regular out-of-competition testing.

Patent and license pearls and pitfalls for taking an idea to the marketplace.

PubMed

Mukharji, Indrani

2011-06-01

Technology transfer is the process by which novel ideas at academic institutions emanating from research supported by public and private funds are transferred to the private sector for developing marketable products for public use and benefit. Because the primary mission of universities is education and research, technology transfer in an academic environment introduces many challenges. This field is new to most faculty members and is seldom a core mission of their academic careers. The process is also new and unfamiliar to most university administrators. However, universities are increasingly challenged to demonstrate how their research with public funds translates into public benefit. Technology transfer by universities has taken on a new dimension with a focus first on protecting the intellectual property emanating from academic research, then finding means to develop and commercialize such intellectual property for launching new products in the market for public use and benefit. The Bayh-Dole Act enacted in 1980 (Public Law 96-517) allowed universities to elect to retain title to inventions arising from their federally funded research and to grant licenses to the patents, copyrights, or trademarks deriving from these inventions. Universities are allowed to retain the royalties and to share them with the inventors. This article presents the perspectives of technology transfer professionals, specifically, what technology transfer offices do or can do to assist researchers with commercialization of the novel ideas in biomedical research. It also provides a list of successful therapeutics that stemmed from academic research. In conclusion, reference is made to some of the challenges of technology transfer.

Technology Transfer and Commercialization

NASA Technical Reports Server (NTRS)

Martin, Katherine; Chapman, Diane; Giffith, Melanie; Molnar, Darwin

2001-01-01

During concurrent sessions for Materials and Structures for High Performance and Emissions Reduction, the UEET Intellectual Property Officer and the Technology Commercialization Specialist will discuss the UEET Technology Transfer and Commercialization goals and efforts. This will include a review of the Technology Commercialization Plan for UEET and what UEET personnel are asked to do to further the goals of the Plan. The major goal of the Plan is to define methods for how UEET assets can best be infused into industry. The National Technology Transfer Center will conduct a summary of its efforts in assessing UEET technologies in the areas of materials and emissions reduction for commercial potential. NTTC is assisting us in completing an inventory and prioritization by commercialization potential. This will result in increased exposure of UEET capabilities to the private sector. The session will include audience solicitation of additional commercializable technologies.

Maximizing profits in international technology transfer

NASA Technical Reports Server (NTRS)

Straube, W.

1974-01-01

Maximum profit can be introduced into international technology transfer by observing the following: (1) ethical and open dealing between the parties; (2) maximum knowledge of all facts concerning the technology, the use of the technology, the market, competition, prices, and alternatives; (3) ability to coordinate exports, service, support activities, licensing and cross licensing; and (4) knowledgeable people which put these factors together.

Applications of aerospace technology in biology and medicine

NASA Technical Reports Server (NTRS)

Beall, H. C.; Beadles, R. L.; Brown, J. N., Jr.; Clingman, W. H.; Courtney, M. W.; Rouse, D. J.; Scearce, R. W.

1979-01-01

Medical products utilizing and incorporating aerospace technology were studied. A bipolar donor-recipient model for medical transfer is presented. The model is designed to: (1) identify medical problems and aerospace technology which constitute opportunities for successful medical products; (2) obtain early participation of industry in the transfer process; and (3) obtain acceptance by medical community of new medical products based on aerospace technology.

NASA New England Outreach Center

NASA Technical Reports Server (NTRS)

2002-01-01

The NASA New England Outreach Center in Nashua, New Hampshire was established to serve as a catalyst for heightening regional business awareness of NASA procurement, technology and commercialization opportunities. Emphasis is placed on small business participation, with the highest priority given to small disadvantaged businesses, women-owned businesses, HUBZone businesses, service disabled veteran owned businesses, and historically black colleges and universities and minority institutions. The Center assists firms and organizations to understand NASA requirements and to develop strategies to capture NASA related procurement and technology opportunities. The establishment of the NASA Outreach Center serves to stimulate business in a historically underserved area. NASA direct business awards have traditionally been highly present in the West, Midwest, South, and Southeast areas of the United States. The Center guides and assists businesses and organizations in the northeast to target opportunities within NASA and its prime contractors and capture business and technology opportunities. The Center employs an array of technology access, one-on-one meetings, seminars, site visits, and targeted conferences to acquaint Northeast firms and organizations with representatives from NASA and its prime contractors to learn about and discuss opportunities to do business and access the inventory of NASA technology. This stimulus of interaction also provides firms and organizations the opportunity to propose the use of their developed technology and ideas for current and future requirements at NASA. The Center provides a complement to the NASA Northeast Regional Technology Transfer Center in developing prospects for commercialization of NASA technology. In addition, the Center responds to local requests for assistance and NASA material and documents, and is available to address immediate concerns and needs in assessing opportunities, timely support to interact with NASA Centers on a local level, and develop easy access to information. The Center acts in the manner of a "NASA Center or Field Office" with direction from NASA Headquarters, Code K.

Spinoff 2002: Fortieth Anniversary Technology Utilization Program

NASA Technical Reports Server (NTRS)

2002-01-01

Since its inception 40 years ago, NASA's Technology Transfer Program has led the way for our nation to benefit from cutting-edge aerospace technologies. In addition to contributing to U.S. economic growth, these technologies are improving the quality of life on Earth while finding new ways to protect and preserve it. NASA's research and development efforts have advanced areas in medicine, communications, manufacturing, computer technology, and homeland security. These breakthroughs, translated into commercial products, are enhancing the lives of Americans everywhere. When a congressional mandate led NASA to develop the Scientific and Technical Information (STI) Program, the Agency began a wide dissemination of its research and development results. In doing so, NASA recognized that many of its technologies were transferable to industry for the development of commercial products. As a result, the Technology Utilization Program was born in 1962. The successful program went through several changes over the years, as its philosophy, mission, and goals adapted into the Technology Transfer Program we know today. The program strives to make the latest technologies available to industry as soon as they are developed. Each year, NASA's Spinoff publication showcases new products and services resulting from commercial partnerships between NASA and private industry. In the 2002 issue, the NASA field centers reflect upon the growth that has made these innovations available to the public. The Research and Development section examines past achievements, current successes, and future goals for each of the ten NASA centers. The Commercial Benefits section proudly highlights 51 new spinoff products, including a heart pump for patients needing a heart transplant, as well as an air purifier that destroys anthrax spores. The Technology Transfer and Outreach section describes the outreach achievements and educational successes made possible through the NASA Commercial Technology Network. Each section of Spinoff 2002 provides compelling evidence of the Technology Transfer Program's success and value. With commercial products and successes spanning from work on the Apollo missions to the International Space Station, the 40th anniversary of the Technology Transfer Program invites us to celebrate our history while planning the future.

Technology transfer of NASA microwave remote sensing system

NASA Technical Reports Server (NTRS)

Akey, N. D.

1981-01-01

Viable techniques for effecting the transfer from NASA to a user agency of state-of-the-art airborne microwave remote sensing technology for oceanographic applications were studied. A detailed analysis of potential users, their needs and priorities; platform options; airborne microwave instrument candidates; ancillary instrumentation; and other, less obvious factors that must be considered were studied. Conclusions and recommendations for the development of an orderly and effective technology transfer of an airborne microwave system that could meet the specific needs of the selected user agencies are reported.

System analysis for technology transfer readiness assessment of horticultural postharvest

NASA Astrophysics Data System (ADS)

Hayuningtyas, M.; Djatna, T.

2018-04-01

Availability of postharvest technology is becoming abundant, but only a few technologies are applicable and useful to a wider community purposes. Based on this problem it requires a significant readiness level of transfer technology approach. This system is reliable to access readiness a technology with level, from 1-9 and to minimize time of transfer technology in every level, time required technology from the selection process can be minimum. Problem was solved by using Relief method to determine ranking by weighting feasible criteria on postharvest technology in each level and PERT (Program Evaluation Review Technique) to schedule. The results from ranking process of post-harvest technology in the field of horticulture is able to pass level 7. That, technology can be developed to increase into pilot scale and minimize time required for technological readiness on PERT with optimistic time of 7,9 years. Readiness level 9 shows that technology has been tested on the actual conditions also tied with estimated production price compared to competitors. This system can be used to determine readiness of technology innovation that is derived from agricultural raw materials and passes certain stages.

Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells.

PubMed

Gonzalez, Gaëlle; Vituret, Cyrielle; Di Pietro, Attilio; Chanson, Marc; Boulanger, Pierre; Hong, Saw-See

2012-01-01

Cell microparticles (MPs) released in the extracellular milieu can embark plasma membrane and intracellular components which are specific of their cellular origin, and transfer them to target cells. The MP-mediated, cell-to-cell transfer of three human membrane glycoproteins of different degrees of complexity was investigated in the present study, using a CHO cell model system. We first tested the delivery of CAR and CD46, two monospanins which act as adenovirus receptors, to target CHO cells. CHO cells lack CAR and CD46, high affinity receptors for human adenovirus serotype 5 (HAdV5), and serotype 35 (HAdV35), respectively. We found that MPs derived from CHO cells (MP-donor cells) constitutively expressing CAR (MP-CAR) or CD46 (MP-CD46) were able to transfer CAR and CD46 to target CHO cells, and conferred selective permissiveness to HAdV5 and HAdV35. In addition, target CHO cells incubated with MP-CD46 acquired the CD46-associated function in complement regulation. We also explored the MP-mediated delivery of a dodecaspanin membrane glycoprotein, the CFTR to target CHO cells. CFTR functions as a chloride channel in human cells and is implicated in the genetic disease cystic fibrosis. Target CHO cells incubated with MPs produced by CHO cells constitutively expressing GFP-tagged CFTR (MP-GFP-CFTR) were found to gain a new cellular function, the chloride channel activity associated to CFTR. Time-course analysis of the appearance of GFP-CFTR in target cells suggested that MPs could achieve the delivery of CFTR to target cells via two mechanisms: the transfer of mature, membrane-inserted CFTR glycoprotein, and the transfer of CFTR-encoding mRNA. These results confirmed that cell-derived MPs represent a new class of promising therapeutic vehicles for the delivery of bioactive macromolecules, proteins or mRNAs, the latter exerting the desired therapeutic effect in target cells via de novo synthesis of their encoded proteins.

The transferability of information and communication technology skills from university to the workplace: a qualitative descriptive study.

PubMed

Bembridge, Elizabeth; Levett-Jones, Tracy; Jeong, Sarah Yeun-Sim

2011-04-01

This paper presents the findings from a study that explored whether the information and communication technology (ICT) skills nurses acquired at university are relevant and transferable to contemporary practice environments. Whilst universities have attempted to integrate information and communication technology into nursing curricula it is not known whether the skills developed for educational purposes are relevant or transferable to clinical contexts. A qualitative descriptive study was used to explore the perspectives of a small group of new graduate nurses working in a regional/semi-metropolitan healthcare facility in New South Wales, Australia. Semi-structured interviews were used and the data thematically analysed. The themes that emerged from the study are presented in accordance with the conceptual framework and structured under the three headings of pre-transfer, transition and post-transfer. The transferability of information and communication technology skills from university to the workplace is impacted by a range of educational, individual, organisational and contextual factors. Access to adequate ICT and the necessary training opportunities influences new graduates' work satisfaction and their future employment decisions. The ability to effectively use information and communication technology was viewed as essential to the provision of quality patient care. Copyright © 2010 Elsevier Ltd. All rights reserved.

77 FR 11750 - Idaho: Final Approval of State Underground Storage Tank Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... defined under Executive Order 12866. I. National Technology Transfer and Advancement Act Section 12(d) of the National Technology Transfer and Advancement Act of 1995 (``NTTAA''), Public Law 104-113, 12(d... the time needed to review instructions; develop, acquire, install, and utilize technology and systems...

76 FR 57659 - Oregon: Final Approval of State Underground Storage Tank Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

... defined under Executive Order 12866. I. National Technology Transfer and Advancement Act Section 12(d) of the National Technology Transfer and Advancement Act of 1995 (``NTTAA''), Public Law 104-113, 12(d... instructions; develop, acquire, install, and utilize technology and systems for the purposes of collecting...

Techno-Nationalism and the Construction of University Technology Transfer

ERIC Educational Resources Information Center

Sá, Creso; Kretz, Andrew; Sigurdson, Kristjan

2013-01-01

Our historical study of Canada's main research university illuminates the overlooked influence of national identities and interests as forces shaping the institutionalization of technology transfer. Through the use of archival sources we trace the rise and influence of Canadian technological nationalism--a response to Canada's perceived dependency…

Applications of aerospace technology in biomedicine. A technology transfer profile: Patient monitoring

NASA Technical Reports Server (NTRS)

Murray, D. M.

1971-01-01

NASA contributions to cardiovascular monitoring are described along with innovations in intracardiac blood pressure monitoring. A brief overview of the process of NASA technology transfer in patient monitoring is presented and a list of bioinstrumentation tech briefs and the number of requests for technical support is included.

Applications of aerospace technology in industry, a technology transfer profile: Plastics

NASA Technical Reports Server (NTRS)

1971-01-01

New plastics technology bred out of the space program has moved steadily into the U.S. economy in a variety of organized and deliberate ways. Examples are presented of the transfer of plastics know-how into the plants and eventually the products of American business.

78 FR 2923 - Proposed Priority-National Institute on Disability and Rehabilitation Research-Disability and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

..., and rehabilitation technology that maximize the full inclusion and integration into society... of individuals with disabilities and further their participation in society. Technology transfer is a... Technology Transfer CFDA Number: 84.133A-08. AGENCY: Office of Special Education and Rehabilitative Services...

Manufacturing process applications team (MATeam)

NASA Technical Reports Server (NTRS)

Bangs, E. R.

1980-01-01

Progress in the transfer of aerospace technology to solve key problems in the manufacturing sector of the economy is reported. Potential RTOP programs are summarized along with dissemination activities. The impact of transferred NASA manufacturing technology is discussed. Specific areas covered include aircraft production, robot technology, machining of alloys, and electrical switching systems.

77 FR 20823 - Prospective Grant of Exclusive License: Family Healthware

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

... Grant of Exclusive License: Family Healthware AGENCY: Technology Transfer Office, Centers for Disease... and Prevention (CDC), Technology Transfer Office, Department of Health and Human Services (DHHS), is... priority to Provisional Patent Application No. 60/650,076, filed 2/3/2005. CDC Technology ID No. I- 004-04...

NASP technology transfer

NASA Technical Reports Server (NTRS)

Morris, Charles

1992-01-01

It is the stated goal of this program, the National AeroSpace Plane (NASP) program, to develop and then demonstrate the technologies for single-stage-to-orbit flight and hypersonic cruise with airbreathing primary propulsion and horizontal takeoff and landing. This presentation is concerned with technology transfer in the context of the NASP program.