Global Combat Support System - Joint Increment 8 (GCSS-J Inc 8)

DTIC Science & Technology

2016-03-01

Acquisition Executive DoD - Department of Defense DoDAF - DoD Architecture Framework FD - Full Deployment FDD - Full Deployment Decision FY - Fiscal...Estimate (Or Actual) Milestone B1 Mar 2014 Mar 2014 Milestone C1 Mar 2014 Mar 2014 Increment 8 FDD Dec 2018 Dec 2018 Increment 8 FD TBD TBD Memo 1

Integrated Unmanned Air-Ground Robotics System, Volume 4

DTIC Science & Technology

2001-08-20

3) IPT Integrated Product Team IRP Intermediate Power Rating JAUGS TBD JCDL TBD Joint Vision 2020 TBD Km Kilometer lbs. pounds MAE Mechanical and...compatible with emerging JCDL and/or JAUGS . 2.3.2.2. Payload must be “plug and play.” 2.3.3. Communications 2.3.3.1. System communications shall be robust...Power JCDL JAUGS Joint Architecture for Unmanned Ground Systems JP-8 Jet Propulsion Fuel 8 km Kilometer lbs. Pounds LOS Line Of Sight MAE Mechanical

Optical Region Spectrophotometry: Past and Present

NASA Astrophysics Data System (ADS)

Adelman, Saul J.

In the 1960s and 1970s optical region spectrophotometry achieved the status of a major tool in stellar research. New instrumentation, rotating grating scanners using photomultiplier tubes as detectors, and improved absolute calibrations of Vega made this possible. After this period the use of this technique declined to its near demise at present. The use of Vega as the primary standard has been both a blessing as it is so bright and a curse especially as modeling it correctly requires treating it as a fast rotating star seen nearly pole-on. It may be better to use several stars to define any future absolute calibration. With absolutely calibrated fluxes and Balmer profiles, often Hγ, investigators used the predictions of model atmospheres to find both the effective temperatures and the surface gravities of stars. The fluxes were photometrically calibrated low dispersion spectra with a typical resolution of order 25 Å. A typical data set consisted of 10-15 values covering most of the optical spectral region. At present two instrumental projects ACCESS and the ASTRA Spectrophotometer promise, respectively, a new substantially improved absolute calibration of the optical fluxes of several targets and the availability of a considerable amount of well-calibrated optical flux data for use in studies concerned with stellar properties. They jointly promise to revive optical region spectrophotometric studies.

Low-acuity presentations to regional emergency departments: What is the issue?

PubMed

Cheek, Colleen; Allen, Penny; Shires, Lizzi; Parry, Denise; Ruigrok, Marielle

2016-04-01

To explore GP-referrals and self-referrals to EDs and factors associated with patients seeking low-acuity care at ED. Retrospective analysis of all ED presentations to Mersey Community Hospital and North West Regional Hospital (Tasmania) between 1 January 2009 and 31 December 2013. Cross-sectional survey of patients presenting to the EDs for care triaged as low-acuity. There were 255,365 ED presentations in the retrospective data: 11,252 (4.4%) GP-referrals and 218,205 (85.4%) self-referrals. At ED 49% of GP-referrals were triaged ATS 4 or 5 and 35% of self-referrals were triaged ATS 1-3. There were 138 (84.2%) low-acuity patients who completed the survey; predominantly, all attended for acute injury or illness. Single point-of-care convenience was most commonly selected (71%) as a reason for attending ED. Over 85% of patients who seek emergency care in this region self-refer, so understanding health-seeking behaviour is important. Most low-acuity patients are acutely injured or unwell, and the decision to go to ED is based on their perception of accessibility of expertise aligned with their need. The term 'GP-type' is misleading in this context and should not be used. Providing low-acuity care in parallel with providing a specialised emergency service meets the needs of the local community and is likely to be the lowest cost model in a regional and rural area. Funding models must reflect the actual cost of delivering this important service rather than presentation types. © 2015 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

Frequency Management for Electromagnetic Continuous Wave Conductivity Meters

PubMed Central

Mazurek, Przemyslaw; Putynkowski, Grzegorz

2016-01-01

Ground conductivity meters use electromagnetic fields for the mapping of geological variations, like the determination of water amount, depending on ground layers, which is important for the state analysis of embankments. The VLF band is contaminated by numerous natural and artificial electromagnetic interference signals. Prior to the determination of ground conductivity, the meter’s working frequency is not possible, due to the variable frequency of the interferences. Frequency management based on the analysis of the selected band using track-before-detect (TBD) algorithms, which allows dynamical frequency changes of the conductivity of the meter transmitting part, is proposed in the paper. Naive maximum value search, spatio-temporal TBD (ST-TBD), Viterbi TBD and a new algorithm that uses combined ST-TBD and Viterbi TBD are compared. Monte Carlo tests are provided for the numerical analysis of the properties for a single interference signal in the considered band, and a new approach based on combined ST-TBD and Viterbi algorithms shows the best performance. The considered algorithms process spectrogram data for the selected band, so DFT (Discrete Fourier Transform) could be applied for the computation of the spectrogram. Real–time properties, related to the latency, are discussed also, and it is shown that TBD algorithms are feasible for real applications. PMID:27070608

Frequency Management for Electromagnetic Continuous Wave Conductivity Meters.

PubMed

Mazurek, Przemyslaw; Putynkowski, Grzegorz

2016-04-07

Ground conductivity meters use electromagnetic fields for the mapping of geological variations, like the determination of water amount, depending on ground layers, which is important for the state analysis of embankments. The VLF band is contaminated by numerous natural and artificial electromagnetic interference signals. Prior to the determination of ground conductivity, the meter's working frequency is not possible, due to the variable frequency of the interferences. Frequency management based on the analysis of the selected band using track-before-detect (TBD) algorithms, which allows dynamical frequency changes of the conductivity of the meter transmitting part, is proposed in the paper. Naive maximum value search, spatio-temporal TBD (ST-TBD), Viterbi TBD and a new algorithm that uses combined ST-TBD and Viterbi TBD are compared. Monte Carlo tests are provided for the numerical analysis of the properties for a single interference signal in the considered band, and a new approach based on combined ST-TBD and Viterbi algorithms shows the best performance. The considered algorithms process spectrogram data for the selected band, so DFT (Discrete Fourier Transform) could be applied for the computation of the spectrogram. Real-time properties, related to the latency, are discussed also, and it is shown that TBD algorithms are feasible for real applications.

Field Organizations: Unit Status Reporting

DTIC Science & Technology

2001-11-15

3 15 PSYOP DEV DET Detachment CDR 12/8 15 TAC PSYOP DET Detachment CDR 13/8 15 TAC PSYOP team Team leader 5/3 15 UAV TBD TBD 16 MAV/ IAV TBD TBD 16 Fox...AR 600–110 Identification, Surveillance, and Administration of Personnel Infected with Human Immuno-deficiency Virus (HIV) AR 601–210 Regular Army...HIV human immunodeficiency virus HMMWV high mobility multipurpose wheeled vehicle HO hospitalized/convalescent leave category of personnel non

Bovine papillomavirus-like particles presenting conserved epitopes from membrane-proximal external region of HIV-1 gp41 induced mucosal and systemic antibodies

PubMed Central

Zhai, Yougang; Zhong, Zhenyu; Zariffard, Mohammadreza; Spear, Gregory T.; Qiao, Liang

2013-01-01

Two conserved epitopes, located in the membrane-proximal external region (MPER) of the human immunodeficiency virus type 1 (HIV-1) gp41, are recognized by two HIV-1 broadly neutralizing antibodies 2F5 and 4E10, and are promising targets for vaccine design in efforts to elicit anti-HIV-1 broadly neutralizing antibodies. Since most HIV-1 infections initiate at mucosal surfaces, induction of mucosal neutralizing antibodies is necessary and of utmost importance to counteract HIV-1 infection. Here, we utilized a mucosal vaccine vector, bovine papillomavirus (BPV) virus-like particles (VLPs), as a platform to present HIV-1 neutralizing epitopes by inserting the extended 2F5 or 4E10 epitope or the MPER domain into D-E loop of BPV L1 respectively. The chimeric VLPs presenting MPER domain resembled the HIV-1 natural epitopes better than the chimeric VLPs presenting single epitopes. Oral immunization of mice with the chimeric VLPs displaying the 2F5 epitope or MPER domain elicited epitope-specific serum IgGs and mucosal secretory IgAs. The induced antibodies specifically recognized the native conformation of MPER in the context of HIV-1 envelope protein. The antibodies induced by chimeric VLPs presenting MPER domain are able to partially neutralize HIV-1 viruses from clade B and clade C. PMID:24055348

Ticks and Tick-Borne Pathogens of the Caribbean: Current Understanding and Future Directions for More Comprehensive Surveillance.

PubMed

Gondard, Mathilde; Cabezas-Cruz, Alejandro; Charles, Roxanne A; Vayssier-Taussat, Muriel; Albina, Emmanuel; Moutailler, Sara

2017-01-01

Ticks are obligate hematophagous arthropods of significant importance to human and veterinary medicine. They transmit a vast array of pathogens, including bacteria, viruses, protozoa, and helminths. Most epidemiological data on ticks and tick-borne pathogens (TBPs) in the West Indies are limited to common livestock pathogens such as Ehrlichia ruminantium, Babesia spp. (i.e., B. bovis and B. bigemina ), and Anaplasma marginale , and less information is available on companion animal pathogens. Of note, human tick-borne diseases (TBDs) remain almost completely uncharacterized in the West Indies. Information on TBP presence in wildlife is also missing. Herein, we provide a comprehensive review of the ticks and TBPs affecting human and animal health in the Caribbean, and introduce the challenges associated with understanding TBD epidemiology and implementing successful TBD management in this region. In particular, we stress the need for innovative and versatile surveillance tools using high-throughput pathogen detection (e.g., high-throughput real-time microfluidic PCR). The use of such tools in large epidemiological surveys will likely improve TBD prevention and control programs in the Caribbean.

Type B drum packages

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCoy, J.C.

1994-08-01

The Type B drum packages (TBD) are conceptualized as a family of containers in which a single 208 L or 114 L (55 gal or 30 gal) drum containing Type B quantities of radioactive material (RAM) can be packaged for shipment. The TBD containers are being developed to fill a void in the packaging and transportation capabilities of the U.S. Department of Energy as no container packaging single drums of Type B RAM exists offering double containment. Several multiple-drum containers currently exist, as well as a number of shielded casks, but the size and weight of these containers present manymore » operational challenges for single-drum shipments. As an alternative, the TBD containers will offer up to three shielded versions (light, medium, and heavy) and one unshielded version, each offering single or optional double containment for a single drum. To reduce operational complexity, all versions will share similar design and operational features where possible. The primary users of the TBD containers are envisioned to be any organization desiring to ship single drums of Type B RAM, such as laboratories, waste retrieval activities, emergency response teams, etc. Currently, the TBD conceptual design is being developed with the final design and analysis to be completed in 1995 to 1996. Testing and certification of the unshielded version are planned to be completed in 1996 to 1997 with production to begin in 1997 to 1998.« less

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101830, and TBD).

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

Carbohydrate-to-insulin ratio is estimated from 300-400 divided by total daily insulin dose in type 1 diabetes patients who use the insulin pump.

PubMed

Kuroda, Akio; Yasuda, Tetsuyuki; Takahara, Mitsuyoshi; Sakamoto, Fumie; Kasami, Ryuichi; Miyashita, Kazuyuki; Yoshida, Sumiko; Kondo, Eri; Aihara, Ken-ichi; Endo, Itsuro; Matsuoka, Taka-aki; Kaneto, Hideaki; Matsumoto, Toshio; Shimomura, Iichiro; Matsuhisa, Munehide

2012-11-01

To optimize insulin dose using insulin pump, basal and bolus insulin doses are widely calculated from total daily insulin dose (TDD). It is recommended that total daily basal insulin dose (TBD) is 50% of TDD and that the carbohydrate-to-insulin ratio (CIR) equals 500 divided by TDD. We recently reported that basal insulin requirement is approximately 30% of TDD. We therefore investigated CIR after adjustment of the proper basal insulin rate. Forty-five Japanese patients with type 1 diabetes were investigated during several weeks of hospitalization. The patients were served standard diabetes meals (25-30 kcal/kg of ideal body weight). Each meal omission was done to confirm basal insulin rate. Target blood glucose level was set at 100 and 150 mg/dL before and 2 h after each meal, respectively. After the basal insulin rate was fixed and target blood glucose levels were achieved, TBD, CIR, TDD, and their products were determined. Mean (±SD) blood glucose levels before and 2 h after meals were 121±47 and 150±61 mg/dL, respectively. TDD was 31.5±9.0 U, and TBD was 27.0±6.5% of TDD. CIR×TDD of breakfast was significantly lower than those of lunch and supper (288±73 vs. 408±92 and 387±83, respectively; P<0.01). CIR has diurnal variance and is estimated from the formula CIR=300/TDD at breakfast or CIR=400/TDD at lunch and supper in type 1 diabetes patients. These results indicate that the insulin dose has been underestimated by using previously established calculations.

Total Bregman Divergence and its Applications to Shape Retrieval.

PubMed

Liu, Meizhu; Vemuri, Baba C; Amari, Shun-Ichi; Nielsen, Frank

2010-01-01

Shape database search is ubiquitous in the world of biometric systems, CAD systems etc. Shape data in these domains is experiencing an explosive growth and usually requires search of whole shape databases to retrieve the best matches with accuracy and efficiency for a variety of tasks. In this paper, we present a novel divergence measure between any two given points in [Formula: see text] or two distribution functions. This divergence measures the orthogonal distance between the tangent to the convex function (used in the definition of the divergence) at one of its input arguments and its second argument. This is in contrast to the ordinate distance taken in the usual definition of the Bregman class of divergences [4]. We use this orthogonal distance to redefine the Bregman class of divergences and develop a new theory for estimating the center of a set of vectors as well as probability distribution functions. The new class of divergences are dubbed the total Bregman divergence (TBD). We present the l 1 -norm based TBD center that is dubbed the t-center which is then used as a cluster center of a class of shapes The t-center is weighted mean and this weight is small for noise and outliers. We present a shape retrieval scheme using TBD and the t-center for representing the classes of shapes from the MPEG-7 database and compare the results with other state-of-the-art methods in literature.

Tissue banking in Asia Pacific region: past, present and future.

PubMed

Nather, Aziz; Mandy, Foong Shi Yun; Ning, Tan; Kaiying, Wang

2018-04-25

Tissue banking in the Asia Pacific regions is driven by two main forces-firstly the International Atomic Energy Agency (IAEA) via Regional Co-operative Agreement projects and secondly by the Asia Pacific Association of Surgical Tissue Banking (APASTB). This overview is written in three sections: (1) History of tissue banking in individual country in the region. (2) History of APASTB. (3) History of IAEA programme in Asia Pacific region. The current status and future of the tissue banking programme in the region will be discussed.

Aortic Elongation and Stanford B Dissection: The Tübingen Aortic Pathoanatomy (TAIPAN) Project.

PubMed

Lescan, M; Veseli, K; Oikonomou, A; Walker, T; Lausberg, H; Blumenstock, G; Bamberg, F; Schlensak, C; Krüger, T

2017-08-01

Aortic elongation has not yet been considered as a potential risk factor for Stanford type B dissection (TBD). The role of both aortic elongation and dilatation in patients with TBD was evaluated. The aortic morphology of a healthy control group (n = 236) and patients with TBD (n = 96) was retrospectively examined using three dimensional computed tomography imaging. Curved multiplanar reformats were used to examine aortic diameters at defined landmarks and aortic segment lengths. Diameters at all landmarks were significantly larger in the TBD group. The greatest diameter difference (56%) was measured in dissected descending aortas (p < .001). The segment with the most considerable difference between the study groups with regard to elongation was the non-dissected aortic arch of patients with TBD (36%; p < .001). Elongation in the aortic arch was accompanied by a diameter increase of 21% (p < .001). In receiver-operating curve analysis, the area under the curve was .85 for the diameter and .86 for the length of the aortic arch. In addition to dilatation, aortic arch elongation is associated with the development of TBD. The diameter and length of the non-dissected aortic arch may be predictive for TBD and may possibly be used for risk assessment in the future. This study provides the basis for further prospective evaluation of these parameters. Copyright © 2017 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Regional alternative transportation evaluation report - region 1

DOT National Transportation Integrated Search

2011-01-21

The U.S. Fish and Wildlife Service (FWS) and the U.S. Department of Transportation (DOT) Volpe Center (Volpe Center) conducted a regional alternative transportation evaluation (RATE) in Region 1, which is comprised of Oregon, Idaho, Washington, and H...

Penalty dynamic programming algorithm for dim targets detection in sensor systems.

PubMed

Huang, Dayu; Xue, Anke; Guo, Yunfei

2012-01-01

In order to detect and track multiple maneuvering dim targets in sensor systems, an improved dynamic programming track-before-detect algorithm (DP-TBD) called penalty DP-TBD (PDP-TBD) is proposed. The performances of tracking techniques are used as a feedback to the detection part. The feedback is constructed by a penalty term in the merit function, and the penalty term is a function of the possible target state estimation, which can be obtained by the tracking methods. With this feedback, the algorithm combines traditional tracking techniques with DP-TBD and it can be applied to simultaneously detect and track maneuvering dim targets. Meanwhile, a reasonable constraint that a sensor measurement can originate from one target or clutter is proposed to minimize track separation. Thus, the algorithm can be used in the multi-target situation with unknown target numbers. The efficiency and advantages of PDP-TBD compared with two existing methods are demonstrated by several simulations.

Penalty Dynamic Programming Algorithm for Dim Targets Detection in Sensor Systems

PubMed Central

Huang, Dayu; Xue, Anke; Guo, Yunfei

2012-01-01

In order to detect and track multiple maneuvering dim targets in sensor systems, an improved dynamic programming track-before-detect algorithm (DP-TBD) called penalty DP-TBD (PDP-TBD) is proposed. The performances of tracking techniques are used as a feedback to the detection part. The feedback is constructed by a penalty term in the merit function, and the penalty term is a function of the possible target state estimation, which can be obtained by the tracking methods. With this feedback, the algorithm combines traditional tracking techniques with DP-TBD and it can be applied to simultaneously detect and track maneuvering dim targets. Meanwhile, a reasonable constraint that a sensor measurement can originate from one target or clutter is proposed to minimize track separation. Thus, the algorithm can be used in the multi-target situation with unknown target numbers. The efficiency and advantages of PDP-TBD compared with two existing methods are demonstrated by several simulations. PMID:22666074

A multiplex serologic platform for diagnosis of tick-borne diseases.

PubMed

Tokarz, Rafal; Mishra, Nischay; Tagliafierro, Teresa; Sameroff, Stephen; Caciula, Adrian; Chauhan, Lokendrasingh; Patel, Jigar; Sullivan, Eric; Gucwa, Azad; Fallon, Brian; Golightly, Marc; Molins, Claudia; Schriefer, Martin; Marques, Adriana; Briese, Thomas; Lipkin, W Ian

2018-02-16

Tick-borne diseases are the most common vector-borne diseases in the United States, with serology being the primary method of diagnosis. We developed the first multiplex, array-based assay for serodiagnosis of tick-borne diseases called the TBD-Serochip. The TBD-Serochip was designed to discriminate antibody responses to 8 major tick-borne pathogens present in the United States, including Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi, Borrelia miyamotoi, Ehrlichia chaffeensis, Rickettsia rickettsii, Heartland virus and Powassan virus. Each assay contains approximately 170,000 12-mer linear peptides that tile along the protein sequence of the major antigens from each agent with 11 amino acid overlap. This permits accurate identification of a wide range of specific immunodominant IgG and IgM epitopes that can then be used to enhance diagnostic accuracy and integrate differential diagnosis into a single assay. To test the performance of the TBD-Serochip, we examined sera from patients with confirmed Lyme disease, babesiosis, anaplasmosis, and Powassan virus disease. We identified a wide range of specific discriminatory epitopes that facilitated accurate diagnosis of each disease. We also identified previously undiagnosed infections. Our results indicate that the TBD-Serochip is a promising tool for a differential diagnosis not available with currently employed serologic assays for TBDs.

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Here the transparent furnace is extracted for servicing. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

DoD Biometrics Collaboration Forum 25-27 Jan 2011. Event Report

DTIC Science & Technology

2011-03-01

GS-15 Level Staffing Marine Corps Action Tracking System ( MCATS ) Entered Staffing 21 December 2010 HQ USMC Receiving Staff Comments GO...SES Level Staffing MCATS TBD HQ USMC Assistant Commandant of the TBD HQ USMC 2011 DoD Biometrics Collaboration Forum Event Report 13...O-6/GS-15 Staffing MCATS Late March 2011 HQ USMC GO/SES Staffing MCATS Early April 2011 HQ USMC ACMC Signature TBD HQ USMC USMC

Space Fence Ground-Based Radar System Increment 1 (Space Fence Inc 1)

DTIC Science & Technology

2015-12-01

Net - Centric Data Strategy and Net-Centric Services Strategy, and the principles and rules identified in the DoD IEA, excepting tactical and...Centric Data Strategy and Net- Centric Services Strategy, and the principles and rules identified in the DoD IEA, excepting tactical and non-IP...Strategy, and the principles and rules identified in the DoD IEA, excepting tactical and non-IP communi- cations. Compliant with TBD Space Fence must

Molecular characterization of Mycobacterium orygis isolates from wild animals of Nepal.

PubMed

Thapa, Jeewan; Nakajima, Chie; Maharjan, Bhagwan; Poudell, Ajay; Suzuki, Yasuhiko

2015-08-01

Mycobacterium orygis, a new member of the Mycobacterium tuberculosis complex, was isolated from a captive spotted deer (Axis axis) and a blue bull (Boselaphus tragocamelus) in Nepal. Analyses by spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) typing, region of difference and single nucleotide polymorphism of genes gyrB, mmpL6, TbD1, PPE55 and Rv2042c confirmed the isolates as M. orygis. Moreover, analyses by spoligotyping (SIT587) as well as MIRU-VNTR showed that the isolates shared a similar pattern with many reported isolates. From previous and the present studies, it can be inferred that South Asia is one of the endemic regions for M. orygis. Further investigation including a larger sample size and different host interaction will help to understand the ecology and epidemiology of M. orygis in Nepal.

Non-Economic Obstacles to Wind Deployment: Issues and Regional Differences (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baring-Gould, I.

2014-05-01

This presentation provides an overview of national obstacles to wind deployment, with regional assessments. A special mention of offshore projects and distributed wind projects is provided. Detailed maps examine baseline capacity, military and flight radar, golden and bald eagle habitat, bat habitat, whooping crane habitat, and public lands. Regional deployment challenges are also discussed.

75 FR 56580 - Notice of Quarterly Report (April 1, 2010-June 30, 2010)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-16

... annual daily traffic)-- increase tourism Efate: Ring Road. and business Traffic Volume (average... Average revenue of SME added to tourism pottery workshops. and artisan Construction and sectors... in the road network. Rural Land Governance Project... 60,392,771 Increase investment 2,185,845 TBD...

Glomus tumor presenting as complex regional pain syndrome of the left upper limb: a case report.

PubMed

Macharia, Chege; Nthumba, Peter M

2015-12-29

Glomus tumors of the hand are rare, benign but debilitating neoplasms arising from the neuromyoarterial glomus body. They may present a diagnostic dilemma, and take years with multiple consultations and investigations before an appropriate diagnosis is made, but once a diagnosis is made, surgical excision is curative. This is a case presentation of a 35-year-old African man who presented with complex regional pain syndrome of his left upper extremity, whose genesis was found to be a glomus tumor of the pulp of his left middle finger. Surgical excision resulted in resolution of the chronic regional pain syndrome and a return to a normal lifestyle. Chronic regional pain syndrome is a rare presentation of a glomus tumor, which has only been previously reported in patients with neurofibromatosis type 1, and one patient who did not have neurofibromatosis. Patients with glomus tumors may spend many years in pain and distress because of misdiagnosis. Sensitization and education of both the public and health care workers will help in early diagnosis and treatment of this otherwise potentially disabling pathology for which surgical excision is curative.

High resolution infrared spectroscopy of [1.1.1]propellane: The region of the ν 9 band

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maki, Arthur; Weber, Alfons; Nibler, Joseph W.

2010-11-01

The region of the infrared-active band of the ν 9 CH2 bending mode [1.1.1]propellane has been recorded at a resolution (0.0025 cm -1) sufficient to distinguish individual rovibrational lines. This region includes the partially overlapping bands ν 9 (e') = 1459 cm -1, 2ν 18 (l = 2, E') = 1430 cm -1, ν 6 + ν 12 (E') = 1489 cm-1, and ν 4 + ν 15 (A 2") = 1518 cm -1. In addition, the difference band ν 4 - ν 15 (A2") was observed in the far infrared near 295 cm -1 and analyzed to give goodmore » constants for the upper ν 4 levels. The close proximities of the four bands in the ν 9 region suggest that Coriolis and Fermi resonance couplings could be significant and theoretical band parameters obtained from Gaussian ab initio calculations were helpful in guiding the band analyses. The analyses of all four bands were accomplished, based on our earlier report of ground state constants determined from combination differences involving more than 4000 pairs of transitions from five fundamental and four combination bands. This paper presents the analyses and the determination of the upper state constants of all four bands in the region of the ν 9 band. Complications were most evident in the 2ν 18 (l = 2, E') band, which showed significant perturbations due to mixing with the nearby 2ν 18 (l = 0, A 1') and ν 4 + ν 12 (E') levels which are either infrared inactive as transitions from the ground state, or, in the latter case, too weak to observe. Finally, these complications are discussed and a comparison of all molecular constants with those available from the ab initio calculations at the anharmonic level is presented.« less

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD). This image is from a digital still camera; higher resolution is not available.

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, and TBD). This composite is from a digital still camera; higher resolution is not available.

76 FR 19131 - Notice of Quarterly Report (October 1, 2010-December 31, 2010)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

...: Ring tourism and Road. business Traffic Volume development. (average annual daily traffic)--Santo: East...,083,742 Average revenue of SME added to tourism pottery workshops. and artisan sectors. Construction... road network. Rural Land Governance Project.. $59,934,615 Increase $6,348,245 TBD. investment in land...

Statistical Track-Before-Detect Methods Applied to Faint Optical Observations of Resident Space Objects

NASA Astrophysics Data System (ADS)

Fujimoto, K.; Yanagisawa, T.; Uetsuhara, M.

arcs in space surveillance are often both short and sparse. FISST methodologies have been applied to the general problem of SSA by many authors, but they generally focus on tracking scenarios with long arcs or assume that line detection is tractable. We will instead focus this work on estimating sensor-level kinematics of RSOs for low SNR too-short arc observations. Once said estimate is made available, track association and simultaneous initial orbit determination may be achieved via any number of proposed solutions to the too-short arc problem, such as those incorporating the admissible region. We show that the benefit of combining FISST-based TBD with too-short arc association goes both ways; i.e., the former provides consistent statistics regarding bearing-only measurements, whereas the latter makes better use of the precise dynamical models nominally applicable to RSOs in orbit determination.

Proceedings of the 8th Matched-Field Processing Workshop, 12-14 June 1996,

DTIC Science & Technology

1996-10-01

and M. B. Porter Active Matched-Field Tracking (AMFT) ............................................ 29 Homer Bucker Matched-Field Track - Before - Detect (TBD...CD I- z - .4 U) - U :T 0 4,) 0j w CfI -ID 0 ci) CD) CD CD o0 0 C 0D CD 0C o 00 Matched-Field Track - Before - Detect (TBD) Processing using SWellEX...surfaces are used in a source-track search. Track - before - detect (TBD) processing makes use of this technique to extract source track information so that the

Distribution of inhalant allergies in pediatric patients presenting with allergic complaints in the Eastern Anatolia Region.

PubMed

Kilic, Mehmet; Taskin, Erdal

2016-08-01

The objective of this study was to define the distribution of inhalant allergens in pediatric patients in whom sensitization was diagnosed with a skin prick test (SPT) who had presented with allergic complaints. In addition, the correlation between the inhalant allergens detected on the SPT and the patients' demographic features, diagnosis, and laboratory findings was defined. A total of 1415 children among the 4056 patients who presented at a clinic in the Eastern Anatolia region with allergic complaints and who had undergone an SPT were included in this study. On the SPT, sensitization to grass pollens was found in 60.1%, cereals pollens in 57.2%, and Dermatophagoides farinae in 21.8% of the patients. Furthermore, on the SPT, incidence of asthma development was 3.96 times higher (odds ratio 3.96, 95% CI: 1.77-6.83; P=0.001) in patients who were allergic to Dermatophagoides farinae. In our study, differences were found in the study region compared to data from around the world and other regions in Turkey in terms of the distribution of allergies and variations in allergens in patients diagnosed due to variations in climate and plants.

10 CFR 1.47 - NRC Regional Offices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... NRC Regional Offices. Each Regional Administrator executes established NRC policies and assigned... 10 Energy 1 2010-01-01 2010-01-01 false NRC Regional Offices. 1.47 Section 1.47 Energy NUCLEAR... response within Regional boundaries set out in § 1.5(b) of this part. ...

10 CFR 1.47 - NRC Regional Offices.

Code of Federal Regulations, 2011 CFR

2011-01-01

... NRC Regional Offices. Each Regional Administrator executes established NRC policies and assigned... 10 Energy 1 2011-01-01 2011-01-01 false NRC Regional Offices. 1.47 Section 1.47 Energy NUCLEAR... response within Regional boundaries set out in § 1.5(b) of this part. ...

The influence of steric hindrance on kinetics and isotope effects in the reaction of 2,2-bis(4-dimethylaminophenyl)-1-nitro-1-(4-nitrophenyl)ethane with DBU base in acetonitrile

NASA Astrophysics Data System (ADS)

Nowak, Iwona; Jarczewski, Arnold

2014-11-01

The pKa value for 2,2-bis(4-dimethylaminophenyl)-1-nitro-1-(4-nitrophenyl)ethane, (dmap)2 (pKa = 25.11) has been measured spectrophotometrically using buffer solutions of a few strong amine bases: 1,8-diazabicyclo[5.4.0]undec-7-ene, (DBU); 1,1,3,3-tetramethylguanidine, (TMG); 1,5,7-triazabicyclo[4.4.0]dec-5-ene, (TBD); 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene, (MTBD) and their salts. The low energy conformers of nitrophenyl nitroalkanes have been determined using the semiempirical PM6 methods, (B3-LYP) density functional theory (DFT) together with the 6-31G(d,p) basis set. The participation of the low energy conformer in the proton transfer reaction to DBU base has been discussed. The kinetic data for proton transfer reactions between (dmap)2 and DBU in acetonitrile (MeCN) at pseudo-first order conditions have been presented. The influence of steric hindrance brought by reacting C-acid and organic base on the stability of the transition state has been discussed. The rates of second-order rate constants for series of nitrophenyl nitroalkanes, NO2PhCHRNO2 (R = Me; Et; iPr; dimethylaminophenyl = (dmap)2) are presented and discussed.

An Integrated Thermal Compensation System for MEMS Inertial Sensors

PubMed Central

Chiu, Sheng-Ren; Teng, Li-Tao; Chao, Jen-Wei; Sue, Chung-Yang; Lin, Chih-Hsiou; Chen, Hong-Ren; Su, Yan-Kuin

2014-01-01

An active thermal compensation system for a low temperature-bias-drift (TBD) MEMS-based gyroscope is proposed in this study. First, a micro-gyroscope is fabricated by a high-aspect-ratio silicon-on-glass (SOG) process and vacuum packaged by glass frit bonding. Moreover, a drive/readout ASIC, implemented by the 0.25 μm 1P5M standard CMOS process, is designed and integrated with the gyroscope by directly wire bonding. Then, since the temperature effect is one of the critical issues in the high performance gyroscope applications, the temperature-dependent characteristics of the micro-gyroscope are discussed. Furthermore, to compensate the TBD of the micro-gyroscope, a thermal compensation system is proposed and integrated in the aforementioned ASIC to actively tune the parameters in the digital trimming mechanism, which is designed in the readout ASIC. Finally, some experimental results demonstrate that the TBD of the micro-gyroscope can be compensated effectively by the proposed compensation system. PMID:24599191

Differentiating functional brain regions using optical coherence tomography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Gil, Daniel A.; Bow, Hansen C.; Shen, Jin-H.; Joos, Karen M.; Skala, Melissa C.

2017-02-01

The human brain is made up of functional regions governing movement, sensation, language, and cognition. Unintentional injury during neurosurgery can result in significant neurological deficits and morbidity. The current standard for localizing function to brain tissue during surgery, intraoperative electrical stimulation or recording, significantly increases the risk, time, and cost of the procedure. There is a need for a fast, cost-effective, and high-resolution intraoperative technique that can avoid damage to functional brain regions. We propose that optical coherence tomography (OCT) can fill this niche by imaging differences in the cellular composition and organization of functional brain areas. We hypothesized this would manifest as differences in the attenuation coefficient measured using OCT. Five functional regions (prefrontal, somatosensory, auditory, visual, and cerebellum) were imaged in ex vivo porcine brains (n=3), a model chosen due to a similar white/gray matter ratio as human brains. The attenuation coefficient was calculated using a depth-resolved model and quantitatively validated with Intralipid phantoms across a physiological range of attenuation coefficients (absolute difference < 0.1cm-1). Image analysis was performed on the attenuation coefficient images to derive quantitative endpoints. We observed a statistically significant difference among the median attenuation coefficients of these five regions (one-way ANOVA, p<0.05). Nissl-stained histology will be used to validate our results and correlate OCT-measured attenuation coefficients to neuronal density. Additional development and validation of OCT algorithms to discriminate brain regions are planned to improve the safety and efficacy of neurosurgical procedures such as biopsy, electrode placement, and tissue resection.

Historical review and insights on the livestock tick-borne disease research of a developing country: The Philippine scenario.

PubMed

Ybañez, Adrian P; Mingala, Claro N; Ybañez, Rochelle Haidee D

2018-04-01

Tick-borne diseases (TBDs) remain to be a global animal health threat. Developing countries like the Philippines is not exempt to this. Despite the potential impact TBDs can give to these countries, local government initiatives and researches remain to be limited. In the Philippines, most epidemiological studies were confined only to specific areas, and predominantly in the Northern Area. Due to its unique geography and limited studies, the current nationwide status of most TBDs could not be clearly established. This review mainly covered published studies and presented challenges in the conduct of TBD research in the Philippines, which may be similar to other Southeast Asian or developing countries. To date, reported livestock TBD pathogens in the Philippines include Anaplasma, Babesia, Theileria, and Mycoplasma spp. With the ubiquitous presence of the Rhipicephalus microplus ticks in the country, it is highly probable that other pathogens transmitted by these vectors could be present. Despite studies on different TBDs in the livestock sector, the Philippine government has not yet heightened its efforts to implement tick control measures as part of the routine animal health program for local farmers. Further studies might be needed to determine the nationwide prevalence of TBDs and the presence of other possible tick species and TBD pathogens. The Philippine scenario may present situations that are similar to other developing countries. Copyright © 2017 Elsevier B.V. All rights reserved.

50 CFR 2.1 - Regional offices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Regional offices. 2.1 Section 2.1 Wildlife... FIELD ORGANIZATION § 2.1 Regional offices. The program operations of the U.S. Fish and Wildlife Service..., endangered species stations, fishery assistance offices, national fish hatcheries, national wildlife refuges...

Comparison of DMSP and SECS region-1 and region-2 ionospheric current boundary

NASA Astrophysics Data System (ADS)

Weygand, J. M.; Wing, S.

2016-06-01

The region-1 and region-2 boundary has traditionally been identified using data from a single spacecraft crossing the auroral region and measuring the large scale changes in the cross track magnetic field. With data from the AUTUMN, CANMOS, CARISMA, GIMA, DTU MGS, MACCS, McMAC, STEP, THEMIS, and USGS ground magnetometer arrays we applied a state-of-art technique based on spherical elementary current system (SECS) method developed by Amm and Viljanen (1999) in order to calculate maps of region-1 and region-2 current system over the North American and Greenland auroral region. Spherical elementary current (SEC) amplitude (proxy for vertical currents) maps can be inferred at 10 s temporal resolution, ~1.5° geographic latitude (Glat), and 3.5° geographic longitude (Glon) spatial resolution. We compare the location of the region-1 and region-2 boundary obtained by the DMSP spacecraft with the region-1 and region-2 boundary observed in the SEC current amplitudes. We find that the boundaries typically agree within 0.2°±1.3°. These results indicate that the location of the region-1 and region-2 boundary can reasonably be determined from ground magnetometer data. The SECS maps represent a value-added product from the magnetometer database and can be used for contextual interpretation in conjunction with other missions as well as help with our understanding of magnetosphere-ionosphere coupling mechanisms using the ground arrays and the magnetospheric spacecraft data.

Comparison of DMSP and SECS region-1 and region-2 ionospheric current boundary✩

PubMed Central

Weygand, J.M.; Wing, S.

2017-01-01

The region-1 and region-2 boundary has traditionally been identified using data from a single spacecraft crossing the auroral region and measuring the large scale changes in the cross track magnetic field. With data from the AUTUMN, CANMOS, CARISMA, GIMA, DTU MGS, MACCS, McMAC, STEP, THEMIS, and USGS ground magnetometer arrays we applied a state-of-art technique based on spherical elementary current system (SECS) method developed by Amm and Viljanen (1999) in order to calculate maps of region-1 and region-2 current system over the North American and Greenland auroral region. Spherical elementary current (SEC) amplitude (proxy for vertical currents) maps can be inferred at 10 s temporal resolution, ~1.5° geographic latitude (Glat), and 3.5° geographic longitude (Glon) spatial resolution. We compare the location of the region-1 and region-2 boundary obtained by the DMSP spacecraft with the region-1 and region-2 boundary observed in the SEC current amplitudes. We find that the boundaries typically agree within 0.2° ± 1.3°. These results indicate that the location of the region-1 and region-2 boundary can reasonably be determined from ground magnetometer data. The SECS maps represent a value-added product from the magnetometer database and can be used for contextual interpretation in conjunction with other missions as well as help with our understanding of magnetosphere-ionosphere coupling mechanisms using the ground arrays and the magnetospheric spacecraft data. PMID:29056861

Comparison of DMSP and SECS region-1 and region-2 ionospheric current boundary.

PubMed

Weygand, J M; Wing, S

2016-06-01

The region-1 and region-2 boundary has traditionally been identified using data from a single spacecraft crossing the auroral region and measuring the large scale changes in the cross track magnetic field. With data from the AUTUMN, CANMOS, CARISMA, GIMA, DTU MGS, MACCS, McMAC, STEP, THEMIS, and USGS ground magnetometer arrays we applied a state-of-art technique based on spherical elementary current system (SECS) method developed by Amm and Viljanen (1999) in order to calculate maps of region-1 and region-2 current system over the North American and Greenland auroral region. Spherical elementary current (SEC) amplitude (proxy for vertical currents) maps can be inferred at 10 s temporal resolution, ~1.5° geographic latitude (Glat), and 3.5° geographic longitude (Glon) spatial resolution. We compare the location of the region-1 and region-2 boundary obtained by the DMSP spacecraft with the region-1 and region-2 boundary observed in the SEC current amplitudes. We find that the boundaries typically agree within 0.2° ± 1.3°. These results indicate that the location of the region-1 and region-2 boundary can reasonably be determined from ground magnetometer data. The SECS maps represent a value-added product from the magnetometer database and can be used for contextual interpretation in conjunction with other missions as well as help with our understanding of magnetosphere-ionosphere coupling mechanisms using the ground arrays and the magnetospheric spacecraft data.

Cholesteatoma in the Sellar Region Presenting as Hypopituitarism and Diabetes Insipidus

PubMed Central

Kong, Xiangyi; Wu, Huanwen; Ma, Wenbin; Li, Yongning; Xing, Bing; Kong, Yanguo; Wang, Renzhi

2016-01-01

Abstract Clinically significant sellar cysts unrelated to pituitary adenomas are uncommon. Intracranial cholesteatomas are also rare and are most common in the middle ear and mastoid region. We report an even rarer case of cholesteatoma in the sellar region—a challenging diagnosis guided by clinical presentations, radiological signs, and biopsy, aiming at emphasize the importance of considering cholesteatoma when making differential diagnoses of sellar lesions. We present a case of cholesteatoma in the sellar region in a 56-year-old man with hypopituitarism, diabetes insipidus, and cystic imaging findings. It was difficult to make an accurate diagnosis before surgery. We present detailed analysis of the patient's disease course and review pertinent literature. The patient underwent a surgical exploration and tumor resection through a transsphenoidal approach. Pathologic results revealed a cholesteatoma. The patient's symptoms improved a lot after surgery, and the postoperative period was uneventful. Taken together, the lesion's imaging appearance, pathological characteristics, and clinical features were all unique features that lead to a diagnosis of cholesteatoma. As we did not see such reports by Pubmed and EMBASE, we believe this is the first reported case of sellar cholesteatoma presenting in this manner. This article emphasized that cholesteatomas, although rare, should be considered part of the differential diagnosis of sellar lesions. PMID:26962793

Petroleum exploration plays and resource estimates, 1989, onshore United States; Region 1, Alaska; Region 2, Pacific Coast

USGS Publications Warehouse

Powers, Richard B.

1993-01-01

This study provides brief discussions of the petroleum geology, play descriptions, and resource estimates of 220 individually assessed exploration plays in all 80 onshore geologic provinces within nine assessment regions of the continental United States in 1989; these 80 onshore provinces were assessed in connection with the determination of the Nation's estimated undiscovered resources of oil and gas. The present report covers the 25 provinces that make up Region 1, Alaska, and Region 2, Pacific Coast. It is our intention to issue Region 3, Colorado Plateau and Basin and Range, and Region 4, Rocky Mountains and Northern Great Plains, in book form as well. Regions 5 through 9 (West Texas and Eastern New Mexico, Gulf Coast, Midcontinent, Eastern Interior and Atlantic Coast) will be released individually, as Open-File Reports.

Catastrophic drought in East Asian monsoon region during Heinrich event 1

NASA Astrophysics Data System (ADS)

Zhou, Xin; Sun, Liguang; Chu, Yangxi; Xia, Zehui; Zhou, Xinying; Li, Xiangzhong; Chu, Zhuding; Liu, Xiangjun; Shao, Da; Wang, Yuhong

2016-06-01

Heinrich event 1 (H1) is an important millennial climate event during the last deglaciation. The substantial decreasing of monsoon strength in the East Asian monsoon region during the H1, as shown by stalagmite δ18O records, has been attributed to the southward shift of the intertropical convergence zone (ITCZ), which is caused by the slowdown/collapse of the Atlantic meridional overturning circulation (AMOC). However, records from different Asian monsoon regions show various trends in precipitation changes during the H1, and these trends cannot be solely interpreted by the southward shift of the ITCZ. In the present study, we reconstructed time-series of East Asian monsoon precipitation between 25,000 and 10,000 a BP from floodplain sediments in the Huai River Basin. A white sediment layer, distinct from other layers in the profile, contains significantly low TOC, tree pollen and fern spore contents, and more positive δ13Corg, and it is deposited during the H1 event. The determined TOC, pollen and δ13Corg time-series, together with previously reported stalagmite δ18O, indicate a catastrophic (severe) drought in Jianghuai Region, one of the East Asian monsoon regions, during the H1. The La Niña condition in tropical Pacific likely also contributes to the catastrophic drought in Jianghuai Region and the precipitation variations in the Asian monsoon region during the H1.

Climate variability and change in high elevation regions: Past, present & future

USGS Publications Warehouse

Diaz, Henry F.; Grosjean, Martin; Graumlich, Lisa J.

2003-01-01

This special issue of Climatic Change contains a series of research and review articles, arising from papers that were presented and discussed at a workshop held in Davos, Switzerland on 25–28 June 2001. The workshop was titled ‘Climate Change at High Elevation Sites: Emerging Impacts’, and was convened to reprise an earlier conference on the same subject that was held in Wengen, Switzerland in 1995 (Diaz et al., 1997). The Davos meeting had as its main goals, a discussion of the following key issues: (1) reviewing recent climatic trends in high elevation regions of the world, (2) assessing the reliability of various biological indicators as indicators of climatic change, and (3) assessing whether physical impacts of climatic change in high elevation areas are becoming evident, and to discuss a range of monitoring strategies needed to observe and to understand the nature of any changes.

Offshore Wind Jobs and Economic Development Impact: Four Regional Scenarios (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tegen, S.

NREL's Jobs and Economic Development Impact (JEDI) Model for Offshore Wind, is a computer tool for studying the economic impacts of fixed-bottom offshore wind projects in the United States. This presentation provides the results of an analysis of four offshore wind development scenarios in the Southeast Atlantic, Great Lakes, Mid-Atlantic, and Gulf of Mexico regions.

Governor Moore Discusses Past and Present Changes in the Region and in West Virginia.

ERIC Educational Resources Information Center

Appalachia, 1986

1986-01-01

West Virginia Governor Arch Moore discusses past and present changes in the Appalachian Region and in West Virginia spurred by the Appalachian Regional Commission. Changes in West Virginia's tax structure, job creation, economic diversification, and public energy facilities are noted as efforts to prepare for the future. (NEC)

Water masers and ammonia (1, 1) and (2, 2) towards six regions in the Carina Nebula

NASA Astrophysics Data System (ADS)

Breen, S. L.; Green, C.-E.; Cunningham, M. R.; Voronkov, M. A.; Horiuchi, S.; Green, J. A.

2018-01-01

We present water maser and ammonia (1, 1) and (2, 2) observations, towards six regions in the Carina Nebula, conducted with the Australia Telescope Compact Array. In total five water masers were detected within two of the target fields, and we provide their accurate positions and characteristics. These five water masers constitute all of the known masers detected towards star formation regions in the Carina Nebula and we argue, that given the evidence for active star formation, and the presence of many high-mass stars, the Carina Nebula is uncharacteristically devoid of masers. Our results are consistent with the Carina Nebula having a lack of young high-mass stars, despite the presence of older high-mass stars. Ammonia (1, 1) and (2, 2) emission was detected towards all but one of the target fields and we find that their linewidths and derived temperatures are consistent with the presence of young star formation regions.

CSUNSat-1 CubeSat – ELaNa XVII

NASA Image and Video Library

2017-04-04

The primary mission of CSUNSat1 is to space test an innovative low temperature capable energy storage system developed by the Jet Propulsion Laboratory, raising its TRL level to 7 from 4 to 5. The success of this energy storage system will enable future missions, especially those in deep space to do more science while requiring less energy, mass and volume. This CubeSat was designed, built, programmed, and tested by a team of over 70 engineering and computer science students at CSUN.  The primary source of funding for CSUNSat1 comes from NASA’s Smallest Technology Partnership program. Launched by NASA’s CubeSat Launch Initiative on the NET April 18, 2017 ELaNa XVII mission on the seventh Orbital-ATK Cygnus Commercial Resupply Services (OA-7) to the International Space Station and deployed on tbd.

USMC Identity Operations Strategy

DTIC Science & Technology

2011-01-01

safety, situational awareness and mission accomplishment • Action Officer Staffing – 2-4 November 2010 – USMC IdOps OIPT • MCATS Staffing – 21 December...10 March 2011 • Location: TBD – Enter into MCATS O-6/GS-15 Staffing – Late March 2011 – GO/SES Staffing – Early April 2011 – ACMC Signature – TBD 10

Prevalence, Clinical Presentation, and Factors Associated With Diabetic Foot Ulcer in Two Regional Hospitals in Cameroon.

PubMed

Tindong, Maxime; Palle, John N; Nebongo, Daniel; Aminde, Leopold Ndemnge; Mboue-Djieka, Yannick; Mbarga, Nicole T Fouda; Dehayem, Mesmin Y; Choukem, Siméon-Pierre

2018-03-01

This study aimed to determine the prevalence of diabetic foot ulcer and high risk for ulceration, describe the clinical presentation, and identify factors associated with diabetic foot ulcer in the Southwest regional hospitals of Cameroon. In this cross-sectional study, data were collected using a structured questionnaire administered to consecutive patients with diabetes. Findings from detailed foot examination were recorded. Diabetic foot ulcer was diagnosed according to the International Working Group on Diabetic Foot (IWGDF) definition. Data were analyzed with Stata IC version 12. Of the 203 participants included, 63.1% were females. Age ranged from 26 to 96 years. The median duration of diabetes was 4.0 years (interquartile range 1.0-8.0 years). The prevalence of diabetic foot ulcer was 11.8% (24), of whom 29.2% (7) had high grade (grades 2 to 4), and most of the ulcers 58.3% (14) were located at the plantar region. The prevalence of high risk for ulceration was 21.8% (39). Loss of protective sensation (OR = 3.73, 95% CI = 1.43-9.71; P = .007), and peripheral arterial disease (OR = 3.48, 95% CI = 1.14-10.56; P = .028) were independently associated with diabetic foot. Diabetic foot ulcer is a common complication among patients with diabetes attending these regional hospitals. Loss of protective sensation, and peripheral arterial disease increase the odds of having diabetic foot ulcer, and we suggest them as the main target of interest for prevention.

On the mode of sperm autoantigen presentation to the regional lymph node of the testis after vasectomy in rats.

PubMed Central

McDonald, S W; Scothorne, R J

1987-01-01

The regional testicular lymph nodes of vasectomised rats, and of sham-operated controls, have been examined, in stained smears of cell suspensions, for the presence of spermatozoa, at intervals of 1-10 weeks after operation. Very few, if any, spermatozoa were found in either group. These findings differ from those reported in rams and boars by Ball & Setchell (1983), and indicate species differences in the mode of presentation of sperm autoantigens to the regional nodes after vasectomy. PMID:3429321

Extreme Evolutionary Conservation of Functionally Important Regions in H1N1 Influenza Proteome

PubMed Central

Warren, Samantha; Wan, Xiu-Feng; Conant, Gavin; Korkin, Dmitry

2013-01-01

The H1N1 subtype of influenza A virus has caused two of the four documented pandemics and is responsible for seasonal epidemic outbreaks, presenting a continuous threat to public health. Co-circulating antigenically divergent influenza strains significantly complicates vaccine development and use. Here, by combining evolutionary, structural, functional, and population information about the H1N1 proteome, we seek to answer two questions: (1) do residues on the protein surfaces evolve faster than the protein core residues consistently across all proteins that constitute the influenza proteome? and (2) in spite of the rapid evolution of surface residues in influenza proteins, are there any protein regions on the protein surface that do not evolve? To answer these questions, we first built phylogenetically-aware models of the patterns of surface and interior substitutions. Employing these models, we found a single coherent pattern of faster evolution on the protein surfaces that characterizes all influenza proteins. The pattern is consistent with the events of inter-species reassortment, the worldwide introduction of the flu vaccine in the early 80’s, as well as the differences caused by the geographic origins of the virus. Next, we developed an automated computational pipeline to comprehensively detect regions of the protein surface residues that were 100% conserved over multiple years and in multiple host species. We identified conserved regions on the surface of 10 influenza proteins spread across all avian, swine, and human strains; with the exception of a small group of isolated strains that affected the conservation of three proteins. Surprisingly, these regions were also unaffected by genetic variation in the pandemic 2009 H1N1 viral population data obtained from deep sequencing experiments. Finally, the conserved regions were intrinsically related to the intra-viral macromolecular interaction interfaces. Our study may provide further insights towards the

10 CFR 960.3-1-3 - Regionality.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for repository...

10 CFR 960.3-1-3 - Regionality.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for repository...

10 CFR 960.3-1-3 - Regionality.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for repository...

10 CFR 960.3-1-3 - Regionality.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for repository...

Health Management and Service Life for Air Force Missiles

DTIC Science & Technology

2011-09-26

prediction of performance will be conducted DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. PA# TBD 24 • Empiricism ...Strategic Missile A&S Approach Overview Empiricism DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. PA# TBD...Extrapolation Simulated Data 25 • Empiricism cannot always predict future state • Mechanistic method enables enhanced predictions • Mechanistic will not be

Infectious disease following travel to developed regions: a snapshot of presentations to an Australian travel medicine clinic.

PubMed

Drewett, George; Leder, Karin

2016-06-01

Much of the travel medicine literature focuses on travel to 'developing' regions by travellers from 'developed' regions; however literature about travel to developed regions is scarce. This article examines presentations to a travel medicine clinic over a 17-year period with illnesses resulting from travel to developed regions. From a cohort of general presentations to the clinic of 1077 patients, 85 patients acquired infections due to travel to developed regions, with a total of 99 infectious diagnoses made. This serves to highlight the risk of infectious disease even among travel to only developed regions, and the importance of travel advice in these situations. © International Society of Travel Medicine, 2016.. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Association between Psoriasis and haplotypes of the IgH 3' Regulatory Region 1.

PubMed

D'Addabbo, Pietro; Serone, Eliseo; Esposito, Maria; Vaccari, Gabriele; Gargioli, Cesare; Frezza, Domenico; Bianchi, Luca

2018-08-30

The association studies of several immune-diseases with the 3' Regulatory Region 1 (3'RR1) increased interest on the role that the region plays in the immune-regulation. The 3'RR1 is a polymorphic region on human chromosome 14q32, acting as a cis-regulative element on the Immunoglobulin constant-gene locus recently considered as super-enhancer. The human 3'RR1 share large sequences with its paralogous 3'RR2, at high level of similarity. Thus, a focused investigation was necessary to discriminate each one of the duplicated components of the two regions and its specific contribution to the immunologic phenotype. One of the duplicated elements is the hs1.2 enhancer. The 3'RR1 alleles of this enhancer were demonstrated to play a role in autoimmune diseases, including Psoriasis. We sequenced a specific region internal to the 3'RR1 in hs1.2 homozygous subjects, to detect SNPs associated to the main alleles of the enhancer. We identified two alternative nine-SNPs haplotypes strictly linked to the allele *1 and *2 of hs1.2, that could be used as markers to further investigate the region and associations to pathology. Finally, we identified two haplotypes, namely E2A1 and E2A2, that strongly support the hypothesis of a relevant effect of the rs35216181 in the onset of Psoriasis when the *2 allele is present. Copyright © 2018 Elsevier B.V. All rights reserved.

The present-day climate of Greenland : a study with a regional climate model

NASA Astrophysics Data System (ADS)

Ettema, J.

2010-04-01

Present-day climate of Greenland Over the past 20 years, the Greenland ice sheet (GrIS) has warmed. This temperature increase can be explained by an increase in downwelling longwave radiation due to a warmer overlying atmosphere. These temperature changes are strongly correlated to changes in the large scale circulation over the ice sheet. Since 1990, the melt has also strongly increased along the ice margins, inducing significant increase in runoff. With no significant change found in the total precipitation, the GrIS surface mass balance (SMB) decreased by 12 Gt yr-1 or 7 kg m-2 yr-1 since 1990. Locally, the SMB trend reaches -90 kg m-2 yr-1 at the western and eastern ice margins. These conclusions are drawn from a modelling study by Janneke Ettema, which discusses the present-day climate and surface mass balance of the GrIS. The emphasis of this research is on understanding the underlying physical processes. Using the regional atmospheric climate model RACMO2/GR at high horizontal resolution (11km) has resulted in unprecedented detail in the ice sheet climatology and SMB. By incorporating processes such as percolation, retention and refreezing of meltwater in the surface parameterisation, the model explicitly calculates how these processes affect snow pack temperature, density and surface albedo. RACMO2/GR shows that the GrIS climate is spatially very variable. Characteristic for the ice sheet climate are the persistent katabatic winds and a quasi-permanent surface temperature deficit. Due to strong radiative cooling and turbulent heat transport towards the surface, the atmospheric boundary layer cools, providing optimal conditions for strong katabatic winds to occur. The strongest temperature deficit and wind speeds are found in the northeastern part of the ice sheet, whereas in the lower ablation zone the temperatures are more moderate due to surface melt and warm air advection. The high-resolution climate model revealed that the surface mass balance of the Gr

BCR-ABL1- positive chronic myeloid leukemia with erythrocytosis presenting as polycythemia vera: a case report.

PubMed

Cornea, Mihaela I Precup; Levrat, Emmanuel; Pugin, Paul; Betticher, Daniel C

2015-04-08

The World Health Organization classification of chronic myeloproliferative disease encompasses eight entities of bone marrow neoplasms, among them Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia and polycythemia vera. Polycythemia vera requires, in the majority of cases (95%), the negativity of Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 rearrangement and the presence of the Janus kinase 2 mutation. We report a case of erythrocytosis as the primary manifestation of a chronic myeloid leukemia, with the presence of the Philadelphia chromosome and the Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 fusion gene, and in the absence of any Janus kinase 2 mutation. A 68-year-old Caucasian woman, with a history of cigarette consumption and obstructive sleep apnoea syndrome (undergoing continuous positive airway pressure treatment) had presented to our institution with fatigue and a hemoglobin level of 18.6g/L, with slight leukocytosis at 16G/L, and no other anomalies on her complete blood cell count. Examination of her arterial blood gases found only a slight hypoxemia; erythropoietin and ferritin levels were very low and could not explain a secondary erythrocytosis. Further analyses revealed the absence of any Janus kinase 2 mutation, thus excluding polycythemia vera. Taken together with a high vitamin B12 level, we conducted a Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 gene analysis and bone marrow cytogenetic analysis, both of which returned positive, leading to the diagnosis of chronic myeloid leukemia. To date, this case is the first description of a Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia, presenting with erythrocytosis as the initial manifestation, and mimicking a Janus kinase 2 V617F-negative polycythemia vera. Her impressive response to imatinib

U.S. public's experience with ticks and tick-borne diseases: Results from national HealthStyles surveys.

PubMed

Hook, Sarah A; Nelson, Christina A; Mead, Paul S

2015-06-01

Surveillance data indicate that tick-borne diseases (TBDs) are a substantial public health problem in the United States, yet information on the frequency of tick exposure and TBD awareness and prevention practices among the general population is limited. The objective of this study was to gain a more complete understanding of the U.S. public's experience with TBDs using data from annual, nationally representative HealthStyles surveys. There were 4728 respondents in 2009, 4050 in 2011, and 3503 in 2012. Twenty-one percent of respondents reported that a household member found a tick on his or her body during the previous year; of these, 10.1% reported consultation with a health care provider as a result. Overall, 63.7% of respondents reported that Lyme disease (LD) occurs in the area where they live, including 49.4% of respondents from the West South Central and 51.1% from the Mountain regions where LD does not occur. Conversely, in the New England and Mid-Atlantic regions where LD, anaplasmosis, and babesiosis are common, 13.9% and 20.8% of respondents, respectively, reported either that no TBDs occur in their area or that they had not heard of any of these diseases. The majority of respondents (51.2%) reported that they did not routinely take any personal prevention steps against tick bites during warm weather. Results from these surveys indicate that exposure to ticks is common and awareness of LD is widespread. Nevertheless, use of TBD prevention measures is relatively infrequent among the U.S. public, highlighting the need to better understand barriers to use of prevention measures. Published by Elsevier GmbH.

Conformity Adequacy Review: Region 1

EPA Pesticide Factsheets

Resources are for air quality and transportation government and community leaders. Information on the adequacy/inadequacy of state implementation plans (SIPs) in EPA Region 1 (CT, ME, MA, NH, RI, VT) is provided here.

Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in mice.

PubMed

Goto, Teppei; Tomikawa, Junko; Ikegami, Kana; Minabe, Shiori; Abe, Hitomi; Fukanuma, Tatsuya; Imamura, Takuya; Takase, Kenji; Sanbo, Makoto; Tomita, Koichi; Hirabayashi, Masumi; Maeda, Kei-ichiro; Tsukamura, Hiroko; Uenoyama, Yoshihisa

2015-01-01

Pulsatile secretion of GnRH plays a pivotal role in follicular development via stimulating tonic gonadotropin secretion in mammals. Kisspeptin neurons, located in the arcuate nucleus (ARC), are considered to be an intrinsic source of the GnRH pulse generator. The present study aimed to determine ARC-specific enhancer(s) of the Kiss1 gene by an in vivo reporter assay. Three green fluorescent protein (GFP) reporter constructs (long, medium length, and short) were generated by insertion of GFP cDNA at the Kiss1 locus. Transgenic female mice bearing the long and medium-length constructs showed apparent GFP signals in kisspeptin-immunoreactive cells in both the ARC and anteroventral periventricular nucleus, in which another population of kisspeptin neurons are located. On the other hand, transgenic mice bearing 5'-truncated short construct showed few GFP signals in the ARC kisspeptin-immunoreactive cells, whereas they showed colocalization of GFP- and kisspeptin-immunoreactivities in the anteroventral periventricular nucleus. In addition, chromatin immunoprecipitation and chromosome conformation capture assays revealed recruitment of unoccupied estrogen receptor-α in the 5'-upstream region and intricate chromatin loop formation between the 5'-upstream and promoter regions of Kiss1 locus in the ARC. Taken together, the present results indicate that 5'-upstream region of Kiss1 locus plays a critical role in Kiss1 gene expression in an ARC-specific manner and that the recruitment of estrogen receptor-α and formation of a chromatin loop between the Kiss1 promoter and the 5' enhancer region may be required for the induction of ARC-specific Kiss1 gene expression. These results suggest that the 5'-upstream region of Kiss1 locus functions as an enhancer for ARC Kiss1 gene expression in mice.

Thermal Imaging of the Periorbital Regions during the Presentation of an Auditory Startle Stimulus

PubMed Central

Gane, Luke; Power, Sarah; Kushki, Azadeh; Chau, Tom

2011-01-01

Infrared thermal imaging of the inner canthi of the periorbital regions of the face can potentially serve as an input signal modality for an alternative access system for individuals with conditions that preclude speech or voluntary movement, such as total locked-in syndrome. However, it is unknown if the temperature of these regions is affected by the human startle response, as changes in the facial temperature of the periorbital regions manifested during the startle response could generate false positives in a thermography-based access system. This study presents an examination of the temperature characteristics of the periorbital regions of 11 able-bodied adult participants before and after a 102 dB auditory startle stimulus. The results indicate that the startle response has no substantial effect on the mean temperature of the periorbital regions. This indicates that thermography-based access solutions would be insensitive to startle reactions in their user, an important advantage over other modalities being considered in the context of access solutions for individuals with a severe motor disability. PMID:22073302

Characterization of Cer-1 cis-regulatory region during early Xenopus development.

PubMed

Silva, Ana Cristina; Filipe, Mário; Steinbeisser, Herbert; Belo, José António

2011-05-01

Cerberus-related molecules are well-known Wnt, Nodal, and BMP inhibitors that have been implicated in different processes including anterior–posterior patterning and left–right asymmetry. In both mouse and frog, two Cerberus-related genes have been isolated, mCer-1 and mCer-2, and Xcer and Xcoco, respectively. Until now, little is known about the mechanisms involved in their transcriptional regulation. Here, we report a heterologous analysis of the mouse Cerberus-1 gene upstream regulatory regions, responsible for its expression in the visceral endodermal cells. Our analysis showed that the consensus sequences for a TATA, CAAT, or GC boxes were absent but a TGTGG sequence was present at position -172 to -168 bp, relative to the ATG. Using a series of deletion constructs and transient expression in Xenopus embryos, we found that a fragment of 1.4 kb of Cer-1 promoter sequence could reproduce the endogenous expression pattern of Xenopus cerberus. A 0.7-kb mcer-1 upstream region was able to drive reporter expression to the involuting mesendodermal cells, while further deletions abolished reporter gene expression. Our results suggest that although no sequence similarity was found between mouse and Xenopus cerberus cis-regulatory regions, the signaling cascades regulating cerberus expression, during gastrulation, is conserved.

Regional climate simulations over complex topography using WRF: Andalusian present climate

NASA Astrophysics Data System (ADS)

Argüeso, D.; Hidalgo-Muñoz, J. M.; Calandria-Hernández, D.; Gámiz-Fortis, S. R.; Esteban-Parra, M. J.; Castro-Díez, Y.

2010-09-01

In this study three WRF simulations were carried out and analyzed to assess its accuracy to describe the main climate features of Southern Spain in terms of maximum temperature, minimum temperature and precipitation. Present climate was represented by the last 30 year of the 20th Century (1970-1999). The model was evaluated using an observational network distributed throughout Andalusia that comprised both temperatures and precipitation. Since comparison between site-specific measurements and model grid points is definitely troublesome due to differences in spatial-scale, a multi-step regionalization strategy was adopted to upscale observational information. This is of particular importance when studying complex topography regions such as Andalusia, with a wide range of climate conditions in a relative small area. Additionally, WRF outputs were also compared with SPAIN02, a 20-km resolution gridded dataset of precipitation for further validation of the model performance. The model set up consisted in two domains with one-way nesting and spectral nudging. The target domain has a resolution of 10km with 136 by 136 points covering the whole Iberian Peninsula and nested in a coarser domain of 30-km resolution and 130 by 120 grid points. Both domains have 35 vertical levels. Three different driving data were used to provide the boundary conditions, one reanalysis (ERA-40) and two control runs from different General Circulation Models (ECHAM5 and CCSM 3.0). A conservative 7-month spin-up period was added to the 30-year simulation so that dependence on initial conditions can be completely removed. Physics options were chosen on the basis of previous parameterization sensitivity tests over Andalusia that led to a compromise configuration that adequately describes the different subclimates. Probability distributions of daily values as well as monthly statistics were examined to determine the uncertainties associated to each variable and take them into consideration for

Appendix 1: Regional summaries - Alaska

Treesearch

Jane M. Wolken; Teresa N. Hollingsworth

2012-01-01

Alaskan forests cover one-third of the state’s 52 million ha of land (Parson et al. 2001), and are regionally and globally significant. Ninety percent of Alaskan forests are classified as boreal, representing 4 percent of the world’s boreal forests, and are located throughout interior and south-central Alaska (fig. A1-1). The remaining 10 percent of Alaskan forests are...

Disentangling the drivers of taxonomic and phylogenetic beta diversities in disturbed and undisturbed subtropical forests

PubMed Central

Liu, Jinliang; Qian, Hong; Jin, Yi; Wu, Chuping; Chen, Jianhua; Yu, Shuquan; Wei, Xinliang; Jin, Xiaofeng; Liu, Jiajia; Yu, Mingjian

2016-01-01

Understanding the relative importance of dispersal limitation and environmental filtering processes in structuring the beta diversities of subtropical forests in human disturbed landscapes is still limited. Here we used taxonomic (TBD) and phylogenetic (PBD), including terminal PBD (PBDt) and basal PBD (PBDb), beta diversity indices to quantify the taxonomic and phylogenetic turnovers at different depths of evolutionary history in disturbed and undisturbed subtropical forests. Multiple linear regression model and distance-based redundancy analysis were used to disentangle the relative importance of environmental and spatial variables. Environmental variables were significantly correlated with TBD and PBDt metrics. Temperature and precipitation were major environmental drivers of beta diversity patterns, which explained 7–27% of the variance in TBD and PBDt, whereas the spatial variables independently explained less than 1% of the variation for all forests. The relative importance of environmental and spatial variables differed between disturbed and undisturbed forests (e.g., when Bray-Curtis was used as a beta diversity metric, environmental variable had a significant effect on beta diversity for disturbed forests but had no effect on undisturbed forests). We conclude that environmental filtering plays a more important role than geographical limitation and disturbance history in driving taxonomic and terminal phylogenetic beta diversity. PMID:27775021

Disentangling the drivers of taxonomic and phylogenetic beta diversities in disturbed and undisturbed subtropical forests

NASA Astrophysics Data System (ADS)

Liu, Jinliang; Qian, Hong; Jin, Yi; Wu, Chuping; Chen, Jianhua; Yu, Shuquan; Wei, Xinliang; Jin, Xiaofeng; Liu, Jiajia; Yu, Mingjian

2016-10-01

Understanding the relative importance of dispersal limitation and environmental filtering processes in structuring the beta diversities of subtropical forests in human disturbed landscapes is still limited. Here we used taxonomic (TBD) and phylogenetic (PBD), including terminal PBD (PBDt) and basal PBD (PBDb), beta diversity indices to quantify the taxonomic and phylogenetic turnovers at different depths of evolutionary history in disturbed and undisturbed subtropical forests. Multiple linear regression model and distance-based redundancy analysis were used to disentangle the relative importance of environmental and spatial variables. Environmental variables were significantly correlated with TBD and PBDt metrics. Temperature and precipitation were major environmental drivers of beta diversity patterns, which explained 7-27% of the variance in TBD and PBDt, whereas the spatial variables independently explained less than 1% of the variation for all forests. The relative importance of environmental and spatial variables differed between disturbed and undisturbed forests (e.g., when Bray-Curtis was used as a beta diversity metric, environmental variable had a significant effect on beta diversity for disturbed forests but had no effect on undisturbed forests). We conclude that environmental filtering plays a more important role than geographical limitation and disturbance history in driving taxonomic and terminal phylogenetic beta diversity.

Functional Effects of Genetic Polymorphisms in the N-acetyltransferase 1 Coding and 3′ Untranslated Regions

PubMed Central

Zhu, Yuanqi; States, J. Christopher; Wang, Yang; Hein, David W.

2011-01-01

BACKGROUND The functional effects of N-acetyltransferase 1 (NAT1) polymorphisms and haplotypes are poorly understood, compromising the validity of associations reported with diseases including birth defects and numerous cancers. METHODS We investigated the effects of genetic polymorphisms within the NAT1 coding region and the 3′-untranslated region (3′-UTR) and their associated haplotypes on N- and O-acetyltransferase catalytic activities, and NAT1 mRNA and protein levels following recombinant expression in COS-1 cells. RESULTS 1088T>A (rs1057126; 3′-UTR) and 1095C>A (rs15561; 3′-UTR) each slightly reduced NAT1 catalytic activity and NAT1 mRNA and protein levels. A 9-base pair (TAATAATAA) deletion between nucleotides 1065-1090 (3′-UTR) reduced NAT1 catalytic activity and NAT1 mRNA and protein levels. In contrast, a 445G>A (rs4987076; V149I), 459G>A (rs4986990; T153T), 640T>G (rs4986783; S214A) coding region haplotype present in NAT1*11 increased NAT1 catalytic activity and NAT1 protein, but not NAT1 mRNA levels. A combination of the 9-base pair (TAATAATAA) deletion and the 445G>A, 459G>A, 640T>G coding region haplotypes, both present in NAT1*11, appeared to neutralize the opposing effects on NAT1 protein and catalytic activity, resulting in levels of NAT1 protein and catalytic activity that did not differ significantly from the NAT1*4 reference. CONCLUSIONS Since 1095C>A (3′-UTR) is the sole polymorphism present in NAT1*3, our data suggests that NAT1*3 is not functionally equivalent to the NAT1*4 reference. Furthermore, our findings provide biological support for reported associations of 1088T>A and 1095C>A polymorphisms with birth defects. PMID:21290563

EPA Region 1 Coast Guard Jurisdictional Boundary - Arcs

EPA Pesticide Factsheets

Jurisdictional boundary between EPA and Coast Guard for EPA Region I. Created from 1:100000 USGS DLGs with greater detail drawn from 1:24000 commercial street data for Region I.This layer is used to determine which agency will be reponsible in the event of an oil spill.

EPA Region 1 Coast Guard Jurisdictional Boundary - Polygons

EPA Pesticide Factsheets

Jurisdictional boundary between EPA and Coast Guard for EPA Region I. Created from 1:100000 USGS DLGs with greater detail drawn from 1:24000 commercial street data for Region I.This layer is used to determine which agency will be reponsible in the event of an oil spill.

Fgfr1 regulates patterning of the pharyngeal region

PubMed Central

Trokovic, Nina; Trokovic, Ras; Mai, Petra; Partanen, Juha

2003-01-01

Development of the pharyngeal region depends on the interaction and integration of different cell populations, including surface ectoderm, foregut endoderm, paraxial mesoderm, and neural crest. Mice homozygous for a hypomorphic allele of Fgfr1 have craniofacial defects, some of which appeared to result from a failure in the early development of the second branchial arch. A stream of neural crest cells was found to originate from the rhombomere 4 region and migrate toward the second branchial arch in the mutants. Neural crest cells mostly failed to enter the second arch, however, but accumulated in a region proximal to it. Both rescue of the hypomorphic Fgfr1 allele and inactivation of a conditional Fgfr1 allele specifically in neural crest cells indicated that Fgfr1 regulates the entry of neural crest cells into the second branchial arch non-cell-autonomously. Gene expression in the pharyngeal ectoderm overlying the developing second branchial arch was affected in the hypomorphic Fgfr1 mutants at a stage prior to neural crest entry. Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration. PMID:12514106

Source Region Identification for Low Latitude Whistlers (L=1.08)

NASA Astrophysics Data System (ADS)

Gokani, S. A.; Singh, R.; Maurya, A. K.; Bhaskara, V.; Cohen, M.; Kumar, S.; Lichtenberger, J.

2014-12-01

Though whistlers are known and studied from past one century, the scientific community still strives to understand the generation and propagation mechanism of whistlers in very low latitude region. One of the solutions comes from locating the causative lightning discharges and source region of low latitude whistlers. In the present study, ~ 2000 whistlers recorded during period of one year (Dec, 2010 to Jan, 2011) at Allahabad (Geomag. lat. 16.79o N; L=1.08), India are correlated with lightning activity detected by World Wide Lightning Location Network (WWLLN) at and around conjugate region. About 63% of whistlers are correlated with the lightning strikes around conjugate region. Further to confirm this correlation, arrival azimuths of causative sferics are determined and the obtained azimuths points towards conjugate region of Allahabad. The characteristics of thunder cloud generating these whistlers are examined and found that the clouds with South-East alignment are more prone to trigger whistler waves. The seasonal and diurnal variation of whistler parameters such as occurrence rate, power spectral density and dispersion are also studied and explained on the basis of ionospheric conditions in low latitudes. The results obtained open a new window to look for the propagation mechanism of low latitude whistlers.

S-2 stage 1/25 scale model base region thermal environment test. Volume 1: Test results, comparison with theory and flight data

NASA Technical Reports Server (NTRS)

Sadunas, J. A.; French, E. P.; Sexton, H.

1973-01-01

A 1/25 scale model S-2 stage base region thermal environment test is presented. Analytical results are included which reflect the effect of engine operating conditions, model scale, turbo-pump exhaust gas injection on base region thermal environment. Comparisons are made between full scale flight data, model test data, and analytical results. The report is prepared in two volumes. The description of analytical predictions and comparisons with flight data are presented. Tabulation of the test data is provided.

Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region.

PubMed

Jiang, Yong-Hui; Wauki, Kekio; Liu, Qian; Bressler, Jan; Pan, Yanzhen; Kashork, Catherine D; Shaffer, Lisa G; Beaudet, Arthur L

2008-01-28

pattern for GOLGA8E and WHDC1L1 because these two genes have highly related sequences that might also be expressed. We have presented an updated version of a sequence-based physical map for a complex chromosomal region, and we raise the possibility of polymorphism in the genomic orientation of the BP1 to BP2 region. The identification of two new proteins GOLGA8E and WHDC1L1 encoded by genes in the 15q11-q13 region may extend our understanding of the molecular basis of PWS. In terms of copy number variation and gene organization, this is one of the most polymorphic regions of the human genome, and perhaps the single most polymorphic region of this type.

78 FR 65321 - Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... below for dates of meetings: 1. Healthcare Safety and Quality Improvement Research (HSQR) Date: October... Healthcare Safety and Quality Improvement Research (HSQR), Healthcare Effectiveness and Outcomes Research... Room TBD), 540 Gaither Road, Rockville, MD 20850. FOR FURTHER INFORMATION CONTACT: (to obtain a roster...

Recommended acetylene line list in the 20-240 cm-1 and 400-630 cm-1 regions: New measurements and global modeling

NASA Astrophysics Data System (ADS)

Jacquemart, David; Lyulin, Oleg; Perevalov, Valery I.

2017-12-01

A new recommended 12C2H2 line list for the 13-248 cm-1 and 390-634 cm-1 regions is presented. It is based on the results of the global modeling of the line positions and intensities performed in Tomsk within the framework of the method of effective operators. To validate the Tomsk calculations new measurements of both line positions and intensities were performed using acetylene spectra recorded between 25 and 680 cm-1 with the AILES-A beamline of SOLEIL synchrotron. Line positions and intensities of 627 transitions belonging to 9 bands have been measured for the first time in this region. Using the results of these new measurements and the published results of the measurements in the 13-248 cm-1 and 390-634 cm-1 regions performed with the same facilities new fittings of the line intensities for the ΔP=0 and ΔP=1 series of transitions have been performed. Here P=5v1+3v2+5v3+v4+v5 is a polyad number, where v1, v2, v3, v4, and v5 are the principal quantum numbers of the acetylene harmonic oscillators. These new sets of the effective dipole moment parameters were used to generate the line list which contains the line positions and intensities of 39 and 29 bands, respectively for the ΔP=0 and ΔP=1 series of transitions. None of these bands is present in the HITRAN 2012 [8] and GEISA 2015 [9] databases. This paper presents the first part of a global work on the validation of Tomsk calculations.

[Natural infection by hemoparasites in calves submitted to chemoprophylaxis at 30 days of age].

PubMed

da Silva, Rosângela A; Corrêa, Fabíola do N; Botteon, Rita de Cássia C M; Botteon, Paulo de Tarso L

2007-01-01

The tick-borne disease (TBD) brings great damages to cattle breeding. The most important etiologic agents are Babesia bigemina, B. bovis and Anaplasma marginale, being the tick Boophilus microplus the main vector. This work reports the occurrence of natural infection by hemoparasites of TBD in 36 calves with high ticks natural infestation submitted to chemoprophylaxis with 30 days year-old. The blood smears from animals of different ages were analized and were found B. bigemina (33.3%), B. bovis (11.1%) and A. marginale (13.9%). Six animals had clinical symptoms (16.7%) and one dead (2.8%). The number of clinical cases ocurred in consequence of an association of factors as high infestation of ticks and low passive immunity in period that calves had not developed enough active immunity.

Advancing integrated tick management to mitigate burden of tick-borne diseases

USDA-ARS?s Scientific Manuscript database

More than half of the world’s population is at risk of exposure to vector-borne pathogens. Annually, more than 1 billion people are infected and more than 1 million die from vector-borne diseases, including those caused by pathogens transmitted by ticks. The problem with tick borne diseases (TBD) is...

A prospective observational study comparing a physiological scoring system with time-based discharge criteria in pediatric ambulatory surgical patients.

PubMed

Armstrong, James; Forrest, Helen; Crawford, Mark W

2015-10-01

Discharge criteria based on physiological scoring systems can be used in the postanesthesia care unit (PACU) to fast-track patients after ambulatory surgery; however, studies comparing physiological scoring systems with traditional time-based discharge criteria are lacking. The purpose of this study was to compare PACU discharge readiness times using physiological vs time-based discharge criteria in pediatric ambulatory surgical patients. We recorded physiological observations from consecutive American Society of Anesthesiologists physical status I-III patients aged 1-18 yr who were admitted to the PACU after undergoing ambulatory surgery in a tertiary academic pediatric hospital. The physiological score was a combination of the Aldrete and Chung systems. Scores were recorded every 15 min starting upon arrival in the PACU. Patients were considered fit for discharge once they attained a score ≥12 (maximum score, 14), provided no score was zero, with the time to achieve a score ≥12 defining the criteria-based discharge (CBD) time. Patients were discharged from the PACU when both the CBD and the existing time-based discharge (TBD) criteria were met. The CBD and TBD data were compared using Kaplan-Meier and log-rank analysis. Observations from 506 children are presented. Median (interquartile range [IQR]) age was 5.5 [2.8-9.9] yr. Median [IQR] CBD and TBD PACU discharge readiness times were 30 [15-45] min and 60 [45-60] min, respectively. Analysis of Kaplan-Meier curves indicated a significant difference in discharge times using the different criteria (hazard ratio, 5.43; 95% confidence interval, 4.51 to 6.53; P < 0.001). All patients were discharged home without incident. This prospective study suggests that discharge decisions based on physiological criteria have the potential for significantly speeding the transit of children through the PACU, thereby enhancing PACU efficiency and resource utilization.

The structure of the regulatory region of the rat L1 (L1Rn, long interspersed repeated) DNA family of transposable elements.

PubMed Central

Furano, A V; Robb, S M; Robb, F T

1988-01-01

Here we report the DNA structure of the left 1.5 kb of two newly isolated full length members of the rat L1 DNA family (L1Rn, long interspersed repeated DNA). In contrast to earlier isolated rat L1 members, both of these contain promoter-like regions that are most likely full length. In addition, the promoter-like region of both members has undergone a partial tandem duplication. A second internal region of the left end of one of the reported members is also tandemly duplicated. The propensity of the left end of rat L1 elements to undergo this form of genetic rearrangement, as well as other structural features revealed by the present work, is discussed in light of the fact that during evolution the otherwise conserved mammalian L1 DNA families have each acquired completely different promoter-like regions. In an accompanying paper [Nur, I., Pascale, E., and Furano, A. V. (1988) Nucleic Acids Res. 16, submitted], we report that one of the rat promoter-like regions can function as a promoter in rat cells when fused to the Escherichia coli chloramphenicol acyltransferase gene. PMID:2845369

Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing's sarcoma in vitro.

PubMed

Jully, Babu; Vijayalakshmi, Ramshankar; Gopal, Gopisetty; Sabitha, Kesavan; Rajkumar, Thangarajan

2012-11-12

Ewing's sarcoma is a malignancy characterized by a specific 11:22 chromosomal translocation which generates a novel EWS-FLI1 fusion protein functioning as an aberrant transcription factor. In the present study, we have further characterized the junction region of the EWS-FLI1 fusion protein. In-silico model of EWS-FLI1 fusion protein was analysed for ligand binding sites, and a putative region (amino acid (aa) 251-343 of the type 1 fusion protein) in the vicinity of the fusion junction was cloned and expressed using bacterial expression. The recombinant protein was characterized by Circular Dichroism (CD). We then expressed aa 251-280 ectopically in Ewing's sarcoma cell-line and its effect on cell proliferation, tumorigenicity and expression of EWS-FLI1 target genes were analysed. Our modelling analysis indicated that Junction region (aa 251-343) encompasses potential ligand biding sites in the EWS-FLI1 protein and when expressed in bacteria was present as soluble form. Ectopically expressing this region in Ewing's sarcoma cells inhibited tumorigenicity, and EWS-FLI1 target genes indicating a dominant negative biological effect. Junction region can be exploited further as target for drug development in future to specifically target EWS-FLI1 in Ewing's Sarcoma.

Automatic regional analysis of myocardial native T1 values: left ventricle segmentation and AHA parcellations.

PubMed

Huang, Hsiao-Hui; Huang, Chun-Yu; Chen, Chiao-Ning; Wang, Yun-Wen; Huang, Teng-Yi

2018-01-01

Native T1 value is emerging as a reliable indicator of abnormal heart conditions related to myocardial fibrosis. Investigators have extensively used the standardized myocardial segmentation of the American Heart Association (AHA) to measure regional T1 values of the left ventricular (LV) walls. In this paper, we present a fully automatic system to analyze modified Look-Locker inversion recovery images and to report regional T1 values of AHA segments. Ten healthy individuals participated in the T1 mapping study with a 3.0 T scanner after providing informed consent. First, we obtained masks of an LV blood-pool region and LV walls by using an image synthesis method and a layer-growing method. Subsequently, the LV walls were divided into AHA segments by identifying the boundaries of the septal regions and by using a radial projection method. The layer-growing method significantly enhanced the accuracy of the derived myocardium mask. We compared the T1 values that were obtained using manual region of interest selections and those obtained using the automatic system. The average T1 difference of the calculated segments was 4.6 ± 1.5%. This study demonstrated a practical and robust method of obtaining native T1 values of AHA segments in LV walls.

Alimentary tract absorption (f1 values) for radionuclides in local and regional fallout from nuclear tests.

PubMed

Ibrahim, Shawki A; Simon, Steven L; Bouville, André; Melo, Dunstana; Beck, Harold L

2010-08-01

This paper presents gastrointestinal absorption fractions (f1 values) for estimating internal doses from local and regional fallout radionuclides due to nuclear tests. The choice of f1 values are based on specific circumstances of weapons test conditions and a review of reported f1 values for elements in different physical and chemical states. Special attention is given to fallout from nuclear tests conducted at the Marshall Islands. We make a distinction between the f1 values for intakes of radioactive materials immediately after deposition (acute intakes) and intakes that occur in the course of months and years after deposition, following incorporation into terrestrial and aquatic foodstuffs (chronic intakes). Multiple f1 values for different circumstances where persons are exposed to radioactive fallout (e.g., local vs. regional fallout and coral vs. continental tests) are presented when supportive information is available. In some cases, our selected f1 values are similar to those adopted by the International Commission on Radiological Protection (ICRP) (e.g., iodine and most actinides). However, f1 values for cesium and strontium derived from urine bioassay data of the Marshallese population are notably lower than the generic f1 values recommended by ICRP, particularly for acute intakes from local fallout (0.4 and 0.05 for Cs and Sr, respectively). The f1 values presented here form the first complete set of values relevant to realistic dose assessments for exposure to local or regional radioactive fallout.

Alimentary Tract Absorption (f1 Values) for Radionuclides in Local and Regional Fallout from Nuclear Tests

PubMed Central

Ibrahim, Shawki; Simon, Steven L; Bouville, André; Melo, Dunstana; Beck, Harold

2009-01-01

This paper presents gastrointestinal absorption fractions (f1 values) for estimating internal doses from local and regional fallout radionuclides due to nuclear tests. The choice of f1 values are based on specific circumstances of weapons test conditions and a review of reported f1 values for elements in different physical and chemical states. Special attention is given to fallout from nuclear tests conducted at the Marshall Islands. We make a distinction between the f1 values for intakes of radioactive materials immediately after deposition (acute intakes) and intakes that occur in the course of months and years after deposition, following incorporation into terrestrial and aquatic foodstuffs (chronic intakes). Multiple f1 values for different circumstances where persons are exposed to radioactive fallout (e.g. local vs. regional fallout and coral vs. continental tests) are presented when supportive information is available. In some cases, our selected f1 values are similar to those adopted by the ICRP (e.g. iodine and most actinides). However, f1 values for cesium and strontium derived from urine bioassay data of the Marshallese population are notably lower than the generic f1 values recommended by ICRP, particularly for acute intakes from local fallout (0.4 and 0.05 for Cs and Sr, respectively. The f1 values presented here form the first complete set of values relevant to realistic dose assessments for exposure to local or regional radioactive fallout. PMID:20622554

A particle filter for multi-target tracking in track before detect context

NASA Astrophysics Data System (ADS)

Amrouche, Naima; Khenchaf, Ali; Berkani, Daoud

2016-10-01

The track-before-detect (TBD) approach can be used to track a single target in a highly noisy radar scene. This is because it makes use of unthresholded observations and incorporates a binary target existence variable into its target state estimation process when implemented as a particle filter (PF). This paper proposes the recursive PF-TBD approach to detect multiple targets in low-signal-to noise ratios (SNR). The algorithm's successful performance is demonstrated using a simulated two target example.

Generation of region 1 current by magnetospheric pressure gradients

NASA Technical Reports Server (NTRS)

Yang, Y. S.; Spiro, R. W.; Wolf, R. A.

1994-01-01

The Rice Convection Model (RCM) is used to illustrate theoretical possibilities for generating region 1 Birkeland currents by pressure gradients on closed field lines in the Earth's magnetosphere. Inertial effects and viscous forces are neglected. The RCM is applied to idealized cases, to emphasize the basic physical ideas rather than realistic representation of the actual magnetosphere. Ionospheric conductance is taken to be uniform, and the simplest possible representations of the magnetospheric plasma are used. Three basic cases are considered: (1) the case of pure northward Interplanetary Magnetic Field (IMF), with cusp merging assumed to create new closed field lines near the nose of the magnetosphere, following the suggestion by Song and Russell (1992); (2) the case where Dungey-type reconnection occurs at the nose, but magnetosheath plasma somehow enters closed field lines on the dawnside and duskside of the merging region, causing a pressure-driven low-latitude boundary layer; and (3) the case where Dungey-type reconnection occurs at the nose, but region 1 currents flow on sunward drifting plasma sheet field lines. In case 1, currents of region 1 sense are generated by pressure gradients, but those currents do not supply the power for ionospheric convection. Results for case 2 suggest that pressure gradients at the inner edge of the low-latitude boundary layer might generate a large fraction of the region 1 Birkeland currents that drive magnetospheric convection. Results for case 3 indicate that pressure gradients in the plasma sheet could provide part of the region 1 current.

Physiographic map of the Sicilian region (1:250,000 scale)

NASA Astrophysics Data System (ADS)

Priori, Simone; Fantappiè, Maria; Costantini, Edoardo A. C.

2015-04-01

Physiographic maps summarize and group the landforms of a territory into homogeneous areas in terms of kind and intensity of main geomorphological process. Most of the physiographic maps have large scale, which is national or continental scale. Other maps have been produced at the semi-detailed scales, while examples at the regional scale are much less common. However, being the Region the main administrative level in Europe, they can be very useful for land planning in many fields, such as ecological studies, risk maps, and soil mapping. This work presents a methodological example of regional physiographic map, compiled at 1:250,000 scale, representing the whole Sicilian region, the largest and most characteristic of Mediterranean island. The physiographic units were classed matching thematich layers (NDVI, geology, DEM, land cover) with the main geomorphological processes that were identified by stereo-interpretation of aerial photographs (1:70,000 scale). In addition, information from other published maps, representing geomorphological forms, aeolian deposits, anthropic terraced slopes, and landslide were used to improve the accuracy and reliability of the map. The classification of the physiographic units, and then the map legend, was built up on the basis of literature and taking into account Italian geomorphological legend. The legend proposed in this map, which can be applied also in other Mediterranean countries, is suitable for different scales. The landform units were grouped on the base of a geomorphological classification of the forms into: anthropogenic, eolian, coastal, valley floor, intermountain fluvial, slope erosional, structural, karstic, and volcanic.

Test Operations Procedure (TOP) 01-1-020 Tropical Regions Environmental Considerations

DTIC Science & Technology

2013-02-08

and Soldier systems tests. 1.3 Purpose. This is an overview TOP and is organized to provide background information on the humid tropical region...processes that foul materiel and interfere with equipment and systems under test. Military testing at present and in the future requires much greater...accordance with the Holdridge Life Zone Classification System18. This system is based on the theory that vegetation structure (type) is directly

Inhibition of CD1 antigen presentation by human cytomegalovirus.

PubMed

Raftery, Martin J; Hitzler, Manuel; Winau, Florian; Giese, Thomas; Plachter, Bodo; Kaufmann, Stefan H E; Schönrich, Günther

2008-05-01

The betaherpesvirus human cytomegalovirus (HCMV) encodes several molecules that block antigen presentation by the major histocompatibility complex (MHC) proteins. Humans also possess one other family of antigen-presenting molecules, the CD1 family; however, the effect of HCMV on CD1 expression is unknown. The majority of CD1 molecules are classified on the basis of homology as group 1 CD1 and are present almost exclusively on professional antigen-presenting cells such as dendritic cells, which are a major target for HCMV infection and latency. We have determined that HCMV encodes multiple blocking strategies targeting group 1 CD1 molecules. CD1 transcription is strongly inhibited by the HCMV interleukin-10 homologue cmvIL-10. HCMV also blocks CD1 antigen presentation posttranscriptionally by the inhibition of CD1 localization to the cell surface. This function is not performed by a known HCMV MHC class I-blocking molecule and is substantially stronger than the blockage induced by herpes simplex virus type 1. Antigen presentation by CD1 is important for the development of the antiviral immune response and the generation of mature antigen-presenting cells. HCMV present in antigen-presenting cells thus blunts the immune response by the blockage of CD1 molecules.

Present statue of Japanese ERS-1 Project

NASA Technical Reports Server (NTRS)

Ishiwada, Yasufumi; Nemoto, Yoshiaki

1986-01-01

Earth Resources Satellite 1 (ERS-1) will be launched in the FY 1990 with the H-1 rocket from Tanegashima Space Center. ERS-1 will seek to firmly establish remote sensing technologies from space by using synthetic aperture radar and optical sensors, as well as primarily exploring for non-renewable resources and also monitoring for land use, agriculture, forestry, fishery, conservation of environment, prevention of disasters, and surveillance of coastal regions. ERS-1 is a joint project in which the main responsibility for the development of the mission equipment is assumed by the Agency of Industrial Science and Technology, MITI, and the Technology Research Association of Resources Remote Sensing System, while that for the satellite itself and launching rocket is assumed by the Science and Technology Agency (STA) and the National Space Development Agency (NASDA). In relation to this project, users have maintained a close working relationship with the manufacturers after submitting their requirements in 1984 on the specifications of the mission equipments. This missions parameters are outlined.

Jupiter Equatorial Region in a Methane Band Time Set 1

NASA Image and Video Library

1998-03-06

Mosaic of an equatorial "hotspot" on Jupiter at 889 nanometers (nm). The mosaic covers an area of 34,000 kilometers by 11,000 kilometers. Light at 889 nm is strongly absorbed by atmospheric methane. This image shows the features of a hazy cloud layer tens of kilometers above Jupiter's main visible cloud deck. This haze varies in height but appears to be present over the entire region. Small patches of very bright clouds may be similar to terrestrial thunderstorms. The dark region near the center of the mosaic is an equatorial "hotspot" similar to the Galileo Probe entry site. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance. North is at the top. The mosaic covers latitudes 1 to 10 degrees and is centered at longitude 336 degrees West. The smallest resolved features are tens of kilometers in size. These images were taken on December 17, 1996, at a range of 1.5 million kilometers by the Solid State Imaging system aboard NASA's Galileo spacecraft. http://photojournal.jpl.nasa.gov/catalog/PIA01200

CSUNSat-1 Team working on their CubeSat at California State University Northridge

NASA Image and Video Library

2015-03-02

CSUNSat-1 Team (Adam Kaplan, James Flynn, Donald Eckels) working on their CubeSat at California State University Northridge. The primary mission of CSUNSat1 is to space test an innovative low temperature capable energy storage system developed by the Jet Propulsion Laboratory, raising its TRL level to 7 from 4 to 5. The success of this energy storage system will enable future missions, especially those in deep space to do more science while requiring less energy, mass and volume. This CubeSat was designed, built, programmed, and tested by a team of over 70 engineering and computer science students at CSUN.  The primary source of funding for CSUNSat1 comes from NASA’s Smallest Technology Partnership program. Launched by NASA’s CubeSat Launch Initiative NET April 18, 2017 ELaNa XVII mission on the seventh Orbital-ATK Cygnus Commercial Resupply Services (OA-7) to the International Space Station and deployed on tbd.

Preparation and characterization of nanorod-like TiO2 and ZnO films used for charge-transport buffer layers in P3HT based organic solar cells

NASA Astrophysics Data System (ADS)

Thao, Tran Thi; Long, Dang Dinh; Truong, Vo-Van; Dinh, Nguyen Nang

2016-08-01

With the aim of findingout the appropriate buffer layers for organic solar cells (OSC), TiO2 and ZnO on ITO/glass were prepared as nanorod-like thin films. The TiO2 films were crystallyzed in the anatase phase and the ZnO films, in the wurtzite structure. The nanorods in both the fims have a similar size of 15 to 20 nm in diameter and 30 to 50 nm in length. The nanorods have an orientation nearly perpendicular to the ITO-substrate surface. From UV-Vis data the bandgap of the TiO2 and ZnO films were determined tobe 3.26 eV and 3.42 eV, respectively. The laminar organic solar cells with added TiO2 and ZnO, namely ITO/TiO2/P3HT:PCBM/LiF/Al (TBD) and ITO/ZnO/P3HT:PCBM/LiF/Al (ZBD)were made for characterization of the energy conversion performance. As a result, comparing to TiO2,the nanorod-likeZnO filmwas found to be a much better buffer layer that made the fill factor improve from a value of 0.60 for TBD to 0.82 for ZBD, and consequently thePCE was enhanced from 0.84 for TBD to 1.17% for ZBD.

77 FR 23193 - Medicare and Medicaid Programs; Electronic Health Record Incentive Program-Stage 2; Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... for electronic medication administration record (eMAR). In addition, in Sec. 495.6(m)(1)(iii) we... description contact information TBD Title: Closing the referral loop: Centers for Medicare Care Coordination... corrected to read ``(ii) Measure. More than 10 percent of medication orders created by authorized providers...

Selection Signature Analysis Implicates the PC1/PCSK1 Region for Chicken Abdominal Fat Content

PubMed Central

Wang, Zhipeng; Zhang, Yuandan; Wang, Shouzhi; Wang, Ning; Ma, Li; Leng, Li; Wang, Shengwen; Wang, Qigui; Wang, Yuxiang; Tang, Zhiquan; Li, Ning; Da, Yang; Li, Hui

2012-01-01

We conducted a selection signature analysis using the chicken 60k SNP chip in two chicken lines that had been divergently selected for abdominal fat content (AFC) for 11 generations. The selection signature analysis used multiple signals of selection, including long-range allele frequency differences between the lean and fat lines, long-range heterozygosity changes, linkage disequilibrium, haplotype frequencies, and extended haplotype homozygosity. Multiple signals of selection identified ten signatures on chromosomes 1, 2, 4, 5, 11, 15, 20, 26 and Z. The 0.73 Mb PC1/PCSK1 region of the Z chromosome at 55.43-56.16 Mb was the most heavily selected region. This region had 26 SNP markers and seven genes, Mar-03, SLC12A2, FBN2, ERAP1, CAST, PC1/PCSK1 and ELL2, where PC1/PCSK1 are the chicken/human names for the same gene. The lean and fat lines had two main haplotypes with completely opposite SNP alleles for the 26 SNP markers and were virtually line-specific, and had a recombinant haplotype with nearly equal frequency (0.193 and 0.196) in both lines. Other haplotypes in this region had negligible frequencies. Nine other regions with selection signatures were PAH-IGF1, TRPC4, GJD4-CCNY, NDST4, NOVA1, GALNT9, the ESRP2-GALR1 region with five genes, the SYCP2-CADH4 with six genes, and the TULP1-KIF21B with 14 genes. Genome-wide association analysis showed that nearly all regions with evidence of selection signature had SNP effects with genome-wide significance (P<10–6) on abdominal fat weight and percentage. The results of this study provide specific gene targets for the control of chicken AFC and a potential model of AFC in human obesity. PMID:22792402

Selection signature analysis implicates the PC1/PCSK1 region for chicken abdominal fat content.

PubMed

Zhang, Hui; Hu, Xiaoxiang; Wang, Zhipeng; Zhang, Yuandan; Wang, Shouzhi; Wang, Ning; Ma, Li; Leng, Li; Wang, Shengwen; Wang, Qigui; Wang, Yuxiang; Tang, Zhiquan; Li, Ning; Da, Yang; Li, Hui

2012-01-01

We conducted a selection signature analysis using the chicken 60k SNP chip in two chicken lines that had been divergently selected for abdominal fat content (AFC) for 11 generations. The selection signature analysis used multiple signals of selection, including long-range allele frequency differences between the lean and fat lines, long-range heterozygosity changes, linkage disequilibrium, haplotype frequencies, and extended haplotype homozygosity. Multiple signals of selection identified ten signatures on chromosomes 1, 2, 4, 5, 11, 15, 20, 26 and Z. The 0.73 Mb PC1/PCSK1 region of the Z chromosome at 55.43-56.16 Mb was the most heavily selected region. This region had 26 SNP markers and seven genes, Mar-03, SLC12A2, FBN2, ERAP1, CAST, PC1/PCSK1 and ELL2, where PC1/PCSK1 are the chicken/human names for the same gene. The lean and fat lines had two main haplotypes with completely opposite SNP alleles for the 26 SNP markers and were virtually line-specific, and had a recombinant haplotype with nearly equal frequency (0.193 and 0.196) in both lines. Other haplotypes in this region had negligible frequencies. Nine other regions with selection signatures were PAH-IGF1, TRPC4, GJD4-CCNY, NDST4, NOVA1, GALNT9, the ESRP2-GALR1 region with five genes, the SYCP2-CADH4 with six genes, and the TULP1-KIF21B with 14 genes. Genome-wide association analysis showed that nearly all regions with evidence of selection signature had SNP effects with genome-wide significance (P<10(-6)) on abdominal fat weight and percentage. The results of this study provide specific gene targets for the control of chicken AFC and a potential model of AFC in human obesity.

Novel risk predictor for thrombus deposition in abdominal aortic aneurysms

NASA Astrophysics Data System (ADS)

Nestola, M. G. C.; Gizzi, A.; Cherubini, C.; Filippi, S.; Succi, S.

2015-10-01

The identification of the basic mechanisms responsible for cardiovascular diseases stands as one of the most challenging problems in modern medical research including various mechanisms which encompass a broad spectrum of space and time scales. Major implications for clinical practice and pre-emptive medicine rely on the onset and development of intraluminal thrombus in which effective clinical therapies require synthetic risk predictors/indicators capable of informing real-time decision-making protocols. In the present contribution, two novel hemodynamics synthetic indicators, based on a three-band decomposition (TBD) of the shear stress signal, are introduced. Extensive fluid-structure computer simulations of patient-specific scenarios confirm the enhanced risk-prediction capabilities of the TBD indicators. In particular, they permit a quantitative and accurate localization of the most likely thrombus deposition in realistic aortic geometries, where previous indicators would predict healthy operation. The proposed methodology is also shown to provide additional information and discrimination criteria on other factors of major clinical relevance, such as the size of the aneurysm.

EPA Region 1 No Discharge Zones

EPA Pesticide Factsheets

This dataset details No Discharge Zones (NDZ) for New England. Boaters may not discharge waste into these areas. Boundaries were determined mostly by Federal Register Environmental Documents in coordination with Massachusetts Coastal Zone Management (MA CZM) and EPA Region 1 Office of Ecosystem Protection (OEP) staff.

Microsatellite polymorphism in the P1 promoter region of the IGF-1 gene is associated with endometrial cancer

PubMed Central

KWASNIEWSKI, WOJCIECH; GOZDZICKA-JOZEFIAK, ANNA; WOLUN-CHOLEWA, MARIA; POLAK, GRZEGORZ; SIEROCINSKA-SAWA, JADWIGA; KWASNIEWSKA, ANNA; KOTARSKI, JAN

2016-01-01

Endometrial carcinoma (EC) is the most common type of gynecological malignancy. Studies have demonstrated that the insulin growth factor (IGF) pathway is implicated in the development of endometrial tumors and that the serum levels of IGF-1 are affected by estrogen. Most EC cells with high microsatellite instability (MSI-H) accumulate mutations at a microsatellite sequence in the IGF-1 gene. The present study investigated the CA repeat polymorphism in the P1 promoter region of the IGF-1 gene among Caucasian females with endometrial hyperplasia, EC and healthy control subjects, whose blood serum and surgical tissue specimens were analyzed. Differences or correlations between the analyzed parameters [serum levels of IGF-1 and IGF binding protein (IGFBP)-1 and IGFBP-3 as well as estrogens among the polymorphisms] were verified using the χ2, Mann-Whitney U, Kruskal-Wallis or Spearman's rank correlation tests. A PCR amplification and DNA sequencing analysis was used for identification of (CA)n repeats in the P1 region of IGF-1. ELISA was used to determine the blood serum levels of IGF-1, IGFBP-1, IGFBP-3 and estrogens. Furthermore, IGF-1 was assessed in endometrial tissues by immunohistochemical analysis. The present study indicated no statistically significant differences between serum levels of IGF-1, IGFBP-1, IGFBP-3 and estrone, estriol and estradiol in the control and study groups. A significant correlation was identified between the IGF-1 levels and estrone levels in the MSI-H polymorphism (r=−0.41, P=0.012) as well as a highly negative correlation between IGF-1 levels and the estradiol levels in the MSI-H polymorphism (r=−0.6, P=0.002). Genotypes without the 19 CA allele were predominantly found in EC. Furthermore, statistical analysis indicated that the number of IGF-1-expressing cells was significantly elevated in MSI-H type 18-20 (P= 0.0072), MSI-L type 19-20 (P=0.025) and microsatellite-stable MSS type 19-19 (P=0.024) compared with those in the MSI-H 20

MENA 1.1 - An Updated Geophysical Regionalization of the Middle East and North Africa

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walters, B.; Pasyanos, M.E.; Bhattacharyya, J.

2000-03-01

This short report provides an update to the earlier LLNL paper entitled ''Preliminary Definition of Geophysical Regions for the Middle East and North Africa'' (Sweeney and Walter, 1998). This report is designed to be used in combination with that earlier paper. The reader is referred to Sweeney and Walter (1998) for all details, including definitions, references, uses, shortcomings, etc., of the regionalization process. In this report we will discuss only those regions in which we have changed the boundaries or velocity structure from that given by the original paper. The paper by Sweeney and Walter (1998) drew on a varietymore » of sources to estimate a preliminary, first-order regionalization of the Middle East and North Africa (MENA), providing regional boundaries and velocity models within each region. The model attempts to properly account for major structural discontinuities and significant crustal thickness and velocity variations on a gross scale. The model can be used to extrapolate sparse calibration data within a distinct geophysical region. This model can also serve as a background model in the process of forming station calibration maps using intelligent interpolation techniques such as kriging, extending the calibration into aseismic areas. Such station maps can greatly improve the ability to locate and identify seismic events, which in turn improves the ability to seismically monitor for underground nuclear testing. The original model from Sweeney and Walter (1998) was digitized to a 1{sup o} resolution, for simplicity we will hereafter refer to this model as MENA 1.0. The new model described here has also been digitized to a 1{sup o} resolution and will be referred to as MENA1.1 throughout this report.« less

Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide.

PubMed

Lee, Sang Beum; Kim, Jeong Hwan; Jin, Deuk-Hee; Jin, Hyung-Joo; Kim, Yong Soo

2016-01-01

Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth, and its activity is suppressed by MSTN propeptide (MSTNpro), the N-terminal part of MSTN precursor cleaved during post-translational MSTN processing. The current study examined which region of flatfish (Paralichthys olivaceus) MSTN-1 propeptide (MSTN1pro) is critical for MSTN inhibition. Six different truncated forms of MSTN1pro containing N-terminal maltose binding protein (MBP) as a fusion partner were expressed in Escherichia coli, and partially purified by an affinity chromatography for MSTN-inhibitory activity examination. Peptides covering different regions of flatfish MSTN1pro were also synthesized for MSTN-inhibitory activity examination. A MBP-fused MSTN1pro region consisting of residues 45-100 had the same MSTN-inhibitory potency as the full sequence flatfish MSTN1pro (residues 23-265), indicating that the region of flatfish MSTN1pro consisting of residues 45-100 is sufficient to maintain the full MSTN-inhibitory capacity. A MBP-fused MSTN1pro region consisting of residues 45-80 (Pro45-80) also showed MSTN-inhibitory activity with a lower potency, and the Pro45-80 demonstrated its MSTN binding capacity in a pull-down assay, indicating that the MSTN-inhibitory capacity of Pro45-80 is due to its binding to MSTN. Flatfish MSTN1pro synthetic peptides covering residues 45-65, 45-70, and 45-80 demonstrated MSTN-inhibitory activities, but not the synthetic peptide covering residues 45-54, indicating that residues 45-65 of flatfish MSTN1pro are essential for MSTN inhibition. In conclusion, current study show that like the mammalian MSTNpro, the MSTN-inhibitory region of flatfish MSTN1pro resides near its N-terminus, and imply that smaller sizes of MSTNpro can be effectively used in various applications designed for MSTN inhibition. Copyright © 2016 Elsevier Inc. All rights reserved.

12 CFR 357.1 - Economically depressed regions.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Purpose. Section 13(k)(5) of the Federal Deposit Insurance Act (12 U.S.C. 1823(k)(5)) provides that the... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Economically depressed regions. 357.1 Section 357.1 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL...

Age- and region-specific imbalances of basal amino acids and monoamine metabolism in limbic regions of female Fmr1 knock-out mice.

PubMed

Gruss, Michael; Braun, Katharina

2004-07-01

The Fragile X syndrome, a common form of mental retardation in humans, originates from the loss of expression of the Fragile X mental retardation gene leading to the absence of the encoded Fragile X mental retardation protein 1 (FMRP). A broad pattern of morphological and behavioral abnormalities is well described for affected humans as well as Fmr1 knock-out mice, a transgenic animal model for the human Fragile X syndrome. In the present study, we examined neurochemical differences between female Fmr1 knock-out and wildtype mice with particular focus on neurotransmission. Significant age- and region-specific differences of basal tissue neurotransmitter and metabolite levels measured by high performance liquid chromatography were found. Those differences were more numerous in juvenile animals (postnatal day (PND) 28-31) compared to adults (postnatal day 209-221). In juvenile female knock-out mice, especially aspartate and taurine were increased in cortical regions, striatum, cerebellum, and brainstem. Furthermore, compared to the wildtype animals, the juvenile knock-out mice displayed an increased level of neuronal inhibition in the hippocampus and brainstem reflected by decreased ratios of (aspartate + glutamate)/(taurine + GABA), as well as an increased dopamine (DA) turnover in cortical regions, striatum, and hippocampus. These results provide the first evidence that the lack of FMRP expression in female Fmr1 knock-out mice is accompanied by age-dependent, region-specific alterations in brain amino acids, and monoamine turnover, which might be related to the reported synaptical and behavioural alterations in these animals.

78 FR 54633 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... Child Development Program (CDP); DD 2652, DD 2606; OMB Control Number 0704- TBD. Needs and Uses: The... Respondent: 1. Average Burden per Response: 10 minutes. Frequency: On occasion. The information from the DD... projection of future program requirements. The information in DD 2652 is used to apply child care fee...

Design, Construction and Evaluation of 1a/JFH1 HCV Chimera by Replacing the Intergenotypic Variable Region

PubMed Central

Ghasemi, Faezeh; Ghayour-Mobarhan, Majid; Pasdar, Alireza; Pourianfar, Hamid; Reza Aghasadeghi, Mohammad; Gouklani, Hamed; Meshkat, Zahra

2016-01-01

Background The E2 glycoprotein is an important encoded hepatitis C virus (HCV) protein that contains three different variable regions. Objectives The aim of the present study was to construct an HCV 1a/JFH1 chimeric virus by replacing the intergenotypic variable region (igVR) fragment of the highly variable region of the E2 gene of the Japanese Fulminant hepatitis genotype 2a JFH1 virus with a similar region of HCV genotype 1a. This chimera was produced as a model virus with the ability to be cultured. We analyzed the adapted virus and the variations of nucleic acids within it. Methods Specific primers were designed for the igVR of HCV genotype 1a followed by the overlap-PCR method for the synthesis of the desired DNA fragment. The amplified igVR-1a chimera gene and pFL-J6/JFH were digested by KpnI and BsiWI restriction enzymes, and the fragment was ligated into pFL-J6/JFH. The recombinant vector was transformed into Escherichia coli JM109 strain competent cells. All clones were confirmed by colony PCR using specific primers, and the confirmed recombinant vector was sequenced. The recombinant vector was targeted for RNA synthesis by T7 RNA polymerase enzyme. RNA transfection was performed in the Huh7.5 cell line. Virus production in several passages and the evaluated viral load were studied using quantitative real-time PCR and ELISA methods. After 30 passages, the RNA virus was extracted and cloned in PCDNA3.1 vector, and was then sequenced Results Quantitative real-time PCR results showed 11,292,514 copies/mL of chimeric virus production in cell culture. The virus production was confirmed using ELISA, which showed a virus core production of 808.2 pg/mL. The results of cloning and sequencing showed that some of the nucleic acids in the chimera virus were changed, affecting the viral behavior in the cell culture. Conclusions Real-time PCR and ELISA showed high levels of production of 1a/JFH1 chimeric HCV in the Huh7.5 cell culture. The constructed virus can be used

Endothelin-1 expression is strongly repressed by AU-rich elements in the 3′-untranslated region of the gene

PubMed Central

2004-01-01

The regulation of the synthesis of the endothelial-derived vasoconstrictor ET-1 (endothelin-1) is a complex process that occurs mainly at the mRNA level. Transcription of the gene accounts for an important part of the regulation of expression, as already described for different modulators such as the cytokine TGF-β (transforming growth factor-β). However, very little is known about mechanisms governing ET-1 expression at the post-transcriptional level. The aim of the present study was to investigate the regulation of the ET-1 expression at this level. Since the 3′-UTR (3′-untranslated region) of mRNAs commonly contains genetic determinants for the post-transcriptional control of gene expression, we focused on the potential role of the 3′-UTR of ET-1 mRNA. Experiments performed with luciferase reporter constructs containing the 3′-UTR showed that this region exerts a potent destabilizing effect. Deletional analyses allowed us to locate this activity within a region at positions 924–1127. Some (but not all) of the AREs (AU-rich elements) present in this region were found to be essential for this mRNA-destabilizing activity. We also present evidence that cytosolic proteins from endothelial cells interact specifically with these RNA elements, and that a close correlation exists between the ability of the AREs to destabilize ET-1 mRNA and the binding of proteins to these elements. Our results are compatible with the existence of a strong repressional control of ET-1 expression mediated by destabilization of the mRNA exerted through the interaction of specific cytosolic proteins with AREs present in the 3′-UTR of the gene. PMID:15595926

Reflections on the nature of genius: on the 300th anniversay of Mikhail Lomonosov (1711-1765)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiltsev, V.; /Fermilab

2012-02-01

This presentation goes beyond celebratory narration of the life and scientific achievements of Russia's first modern scientist Mikhail Vasilievich Lomonosov (1711-1765). Coming from the notion of complexity of sciences, we introduce 'a genius formula' G = TBD for semi-qualitative evaluation of a person's impact on the society, distinguish two type of geniuses, give several examples and draw general conclusions. The work largely follows presentation at the Fermilab Colloquium in November of 2011.

The Hidden Dynamics of Relativistic Electrons (0.7-1.5 MeV) in the Inner Zone and Slot Region

NASA Astrophysics Data System (ADS)

Claudepierre, S. G.; O'Brien, T. P., III; Blake, J. B.; Fennell, J. F.; Looper, M. D.; Roeder, J. L.; Clemmons, J. H.; Mazur, J. E.; Turner, D. L.; Reeves, G. D.; Spence, H. E.

2016-12-01

We present Van Allen Probes ECT/MagEIS observations of relativistic electrons (0.7-1.5 MeV) in the inner zone and slot region. We describe several approaches that are used to remove background contamination from the measurements, which in these regions is primarily due to very energetic inner zone protons. This careful analysis reveals that electrons with energies in excess of 1 MeV penetrated the slot region and into the inner zone following both the March and June 2015 geomagnetic storms. We also present evidence that electrons of these energies were present in the inner radiation belt region during earlier times in the Van Allen Probes era (e.g., in 2013). For both the March and June 2015 events, we examine pitch-angle distributions that shed light on the relevant physical processes responsible for the growth and decay of such relativistic electron enhancements in the inner zone and slot. We briefly discuss initial attempts to place an upper limit on the MeV electron flux intensity in the inner zone.

75 FR 38090 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

..., (Security and Safety Office), ATTN: Ms. Rose Chunik, 4040 North Fairfax Drive, Arlington, VA 22203, or call... Activity School Volunteer Application; DoDEA Form 4700.3-F1; OMB Number 0704-TBD. Needs and Uses: This information collection requirement is necessary to determine if a school volunteer applicant is suitable for a...

Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition.

PubMed

Levin, Raz; Heresco-Levy, Uriel; Bachner-Melman, Rachel; Israel, Salomon; Shalev, Idan; Ebstein, Richard P

2009-07-01

Arginine vasopressin and the arginine vasopressin 1a (AVPR1a) gene contribute to a range of social behaviors both in lower vertebrates and in humans. Human promoter-region microsatellite repeat regions (RS1 and RS3) in the AVPR1a gene region have been associated with autism spectrum disorders, prosocial behavior and social cognition. Prepulse inhibition (PPI) of the startle response to auditory stimuli is a largely autonomic response that resonates with social cognition in both animal models and humans. Reduced PPI has been observed in disorders including schizophrenia that are distinguished by deficits in social skills. In the current investigation association was examined between PPI and the AVPR1a RS1 and RS repeat regions and PPI in a group of 113 nonclinical subjects. Using a robust family-based strategy, association was observed between AVPR1a promoter-region repeat length, especially RS3) and PPI (30 ms: global p=0.04; 60 ms p=0.006; 120 ms p=0.008). Notably, longer RS3 alleles were associated with greater levels of prepulse inhibition. Using a short/long classification scheme for the repeat regions, significant association was also observed between all three PPI intervals (30, 60 and 120 ms) and both RS1 and RS3 polymorphisms (PBAT: FBAT-PC(2) statistic p=0.047). Tests of within-subject effects (SPSS GLM) showed significant sexxRS3 interactions at 30 ms (p=0.045) and 60 ms (p=0.01). Longer alleles, especially in male subjects, are associated with significantly higher PPI response, consistent with a role for the promoter repeat region in partially molding social behavior in both animals and humans. This is the first report in humans demonstrating a role of the AVPR1a gene in contributing to the PPI response to auditory stimuli.

Tularaemia presenting as parapharyngeal abscess: case presentation.

PubMed

Koc, S; Gürbüzler, L; Yaman, H; Eyibilen, A; Salman, N; Ekici, A

2012-05-01

We report an extremely rare case of the oropharyngeal form of tularaemia, causing a parapharyngeal abscess. A 48-year-old woman presented with fever, sore throat, breathing difficulty and a right-sided neck swelling. This mass had previously been treated with penicillin without response, and had already been surgically drained once in another hospital. On physical examination, the tonsils were exudative and hypertrophic and the pharynx was hyperaemic. A fluctuant, 4 × 4 cm mass was seen on endoscopic examination, originating from the left parapharyngeal area and protruding towards the pyriform sinus, and partly obstructing the airway. Microagglutination test antibody titres for Francisella tularensis were positive (1/1280). The patient healed completely after definitive drainage of the abscess and antimicrobial therapy for 14 days (streptomycin, 2 × 1 g intramuscularly). Tularaemia should be considered in the differential diagnosis of patients presenting with tonsillopharyngitis, cervical lymphadenitis and parapharyngeal abscess who do not respond to treatment with penicillin, even if they do not live in an endemic region.

Physical and transcriptional map in the CMT 1A region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chevillard, C.; Passage, E.; Cudrey, C.

1994-09-01

The Charcot-Marie-Tooth disease type 1A (CMT1A) has been mapped to the proximal short arm of chromosome 17. CMT1A is the most frequent of the motor and sensory peripheral neuropathies and is associated with a duplication of a 1.5 Mb fragment in proximal 17p12. Several groups have proposed that the gene coding for peripheral myelin protein-22 (PMP-22) as the candidate gene for CMT1A. We have recently published a {open_quote}MegaYAC{close_quote} contig of 6 Mb which covers the CMT1A critical region. In order to isolate new genes localized in this region, we used a {open_quote}physical trapping {close_quote} strategy derived from the direct cDNAmore » selection technique developed by Parimoo et al. This approach has allowed us to construct cDNA {open_quotes}minilibraries{close_quotes} using YAC DNA from the CMT1A region. One of the clones in these minilibraries has been mapped back to the CMT1A duplication. Other potentially interesting clones are in the process of further characterization. Furthermore, we have mapped several Genethon microsatellites in the 6 Mb YAC contig and some are located in the CMT1A duplicated region. These highly polymorphic markers should prove useful for diagnostic testing in CMT1A.« less

"Modeled and measured carbon cycling in Mojave Desert soils: toward present and projected greenhouse gas budgets for arid regions

NASA Astrophysics Data System (ADS)

Maurer, G. E.; Amundson, R.; Lammers, L. N.; Mills, J.; Oerter, E.

2017-12-01

Drylands comprise roughly 35% of the Earth's surface, store globally significant amounts of carbon, and cycle this carbon at rates that vary greatly from year to year. Consequently, drylands are thought to contribute to inter-annual changes in the global atmospheric CO2 budget. Sparse measurements and limited process-based modeling have made quantifying dryland carbon cycling at regional or larger scales a major challenge. We parameterized and ran the DayCent model, an ecosystem model that simulates soil C and N cycling and greenhouse gas (GHG) fluxes, using long-term regional climate, soil, and vegetation data for the Mojave Desert region (southwest USA). DayCent predicted somewhat greater soil organic C than was observed in a database of 186 measured Mojave soil survey samples, but successfully recreated climate-driven patterns in soil carbon storage across the landscape. Modeled soil organic carbon storage increased by between 4.1 and 5.1 kg/m2 per km of elevation gained, while Mojave soil survey data indicated an increase of 4.6 kg/m2. Model predictions of soil CO2 flux were validated and calibrated against field observations from ten Mojave soil gas profile studies sampled intermittently between 1986 and the present. DayCent had a tendency to overestimate soil respiration measured at some sites by up to 600% compared to profile measurements. Modeled soil CO2 fluxes increased by between 1280 and 4141 kg/ha/yr per km of elevation gained.This elevational pattern did not match well with landscape-level changes in observed soil profile CO2 flux data, indicating further calibration of DayCent will be needed to produce regional estimates of GHG flux. This ongoing synthesis of modeling and measurements extends the current knowledge of the Mojave's contribution to the global GHG budget and will provide a basis from which to project future emissions from the Mojave and other dryland regions.

Thermal denaturation of the BRCT tandem repeat region of human tumour suppressor gene product BRCA1.

PubMed

Pyrpassopoulos, Serapion; Ladopoulou, Angela; Vlassi, Metaxia; Papanikolau, Yannis; Vorgias, Constantinos E; Yannoukakos, Drakoulis; Nounesis, George

2005-04-01

Reduced stability of the tandem BRCT domains of human BReast CAncer 1 (BRCA1) due to missense mutations may be critical for loss of function in DNA repair and damage-induced checkpoint control. In the present thermal denaturation study of the BRCA1 BRCT region, high-precision differential scanning calorimetry (DSC) and circular dichroism (CD) spectroscopy provide evidence for the existence of a denatured state that is structurally very similar to the native. Consistency between theoretical structure-based estimates of the enthalpy (DeltaH) and heat capacity change (DeltaCp) and the calorimetric results is obtained when considering partial thermal unfolding contained in the region of the conserved hydrophobic pocket formed at the interface of the two BRCT repeats. The structural integrity of this region has been shown to be crucial for the interaction of BRCA1 with phosphorylated peptides. In addition, cancer-causing missense mutations located at the inter-BRCT-repeat interface have been linked to the destabilization of the tandem BRCT structure.

The molecular genetics of the telomere biology disorders.

PubMed

Bertuch, Alison A

2016-08-02

The importance of telomere function for human health is exemplified by a collection of Mendelian disorders referred to as the telomere biology disorders (TBDs), telomeropathies, or syndromes of telomere shortening. Collectively, the TBDs cover a spectrum of conditions from multisystem disease presenting in infancy to isolated disease presentations in adulthood, most notably idiopathic pulmonary fibrosis. Eleven genes have been found mutated in the TBDs to date, each of which is linked to some aspect of telomere maintenance. This review summarizes the molecular defects that result from mutations in these genes, highlighting recent advances, including the addition of PARN to the TBD gene family and the discovery of heterozygous mutations in RTEL1 as a cause of familial pulmonary fibrosis.

Detailed CO(J = 1-0, 2-1, and 3-2) observations toward an H II region RCW 32 in the Vela Molecular Ridge

NASA Astrophysics Data System (ADS)

Enokiya, Rei; Sano, Hidetoshi; Hayashi, Katsuhiro; Tachihara, Kengo; Torii, Kazufumi; Yamamoto, Hiroaki; Hattori, Yusuke; Hasegawa, Yutaka; Ohama, Akio; Kimura, Kimihiro; Ogawa, Hideo; Fukui, Yasuo

2018-05-01

We performed CO(J = 1-0, 2-1, and 3-2) observations toward an H II region RCW 32 in the Vela Molecular Ridge. The CO gas distribution associated with the H II region was revealed for the first time at a high resolution of 22″. The results revealed three distinct velocity components which show correspondence with the optical dark lanes and/or Hα distribution. Two of the components show complementary spatial distribution which suggests collisional interaction between them at a relative velocity of ˜ 4 km s-1. Based on these results, we present a hypothesis that a cloud-cloud collision determined the cloud distribution and triggered formation of the exciting star ionizing RCW 32. The collision time scale is estimated from the cloud size and the velocity separation to be ˜2 Myr and the collision terminated ˜1 Myr ago, which is consistent with the age of the exciting star and the associated cluster. By combing the previous works on the H II regions in the Vela Molecular Ridge, we argue that the majority (at least four) of the H II regions in the Ridge were formed by triggering of cloud-cloud collision.

The world at 1.5°C: Understanding its regional dimensions and driving processes

NASA Astrophysics Data System (ADS)

Seneviratne, S. I.; Wartenburger, R.; Vogel, M.; Hirsch, A.; Guillod, B.; Donat, M.; Pitman, A. J.; Davin, E.; Greve, P.; Hirschi, M.

2017-12-01

This presentation reviews the available evidence regarding projected regional changes in climate extremes at 1.5°C vs higher levels of warming based on recent analyses (Seneviratne et al. 2016; Wartenburger et al., submitted; Greve et al., submitted). In several regions, significant differences in the occurrence of climate extremes can be identified already for half a degree of warming when assessing changes at 1.5°C vs 2°C global warming. An important feature is the much stronger warming of hot extremes in several continental regions compared to the global mean warming, which implies that temperature extremes can warm regionally by much more than 1.5°C, even if global temperature warming is stabilized at this level (e.g. up to 6°C for certain models in the Arctic). This feature is due to a combination of feedbacks and internal climate variability. We highlight in particular the importance of land-climate feedbacks for projected changes in hot extremes in mid-latitude regions (Vogel et al. 2017). Because of the strong effects of land processes on regional changes in temperature extremes, changes in land surface properties, including land use changes, are found to be particularly important for projections in low-emissions scenarios (Hirsch et al. 2017; Guillod et al., submitted). References: Greve, P., et al.: Regional scaling of annual mean precipitation and water availability with global temperature change. Submitted. Guillod, B.P., et al.: Land use in low climate warming targets critical for hot extreme projections. Submitted. Hirsch, A.L., et al., 2017: Can climate-effective land management reduce regional warming? J. Geophys. Res. Atmos., 122, 2269-2288, doi:10.1002/2016JD026125. Seneviratne, S.I., et al., 2016: Allowable CO2 emissions based on regional and impact-related climate targets. Nature, 529, 477-483, doi:10.1038/nature16542. Vogel, M.M., et al., 2017: Regional amplification of projected changes in extreme temperatures strongly controlled by soil

Jupiter's Equatorial Region in a Methane band (Time set 1)

NASA Technical Reports Server (NTRS)

1997-01-01

Mosaic of an equatorial 'hotspot' on Jupiter at 889 nanometers (nm). The mosaic covers an area of 34,000 kilometers by 11,000 kilometers. Light at 889 nm is strongly absorbed by atmospheric methane. This image shows the features of a hazy cloud layer tens of kilometers above Jupiter's main visible cloud deck. This haze varies in height but appears to be present over the entire region. Small patches of very bright clouds may be similar to terrestrial thunderstorms. The dark region near the center of the mosaic is an equatorial 'hotspot' similar to the Galileo Probe entry site. These features are holes in the bright, reflective, equatorial cloud layer where warmer thermal emission from Jupiter's deep atmosphere can pass through. The circulation patterns observed here along with the composition measurements from the Galileo Probe suggest that dry air may be converging and sinking over these regions, maintaining their cloud-free appearance.

North is at the top. The mosaic covers latitudes 1 to 10 degrees and is centered at longitude 336 degrees West. The smallest resolved features are tens of kilometers in size. These images were taken on December 17, 1996, at a range of 1.5 million kilometers by the Solid State Imaging system aboard NASA's Galileo spacecraft.

The Jet Propulsion Laboratory, Pasadena, CA manages the mission for NASA's Office of Space Science, Washington, DC.

This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at URL http://galileo.jpl.nasa.gov. Background information and educational context for the images can be found at URL http://www.jpl.nasa.gov/galileo/sepo

Functional analysis of the NH{sub 2}-terminal hydrophobic region and BRICHOS domain of GKN1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Jung Hwan; Choi, Yoo Jin; Choi, Won Suk

2013-11-01

Highlights: •NH{sub 2}-terminal and BRICHOS domain of GKN1 inhibited tumor cell growth. •NH{sub 2}-terminal and BRICHOS domain of GKN1 regulated cell cycle. •NH{sub 2}-terminal and BRICHOS domain of GKN1 inhibited epigenetic regulators. -- Abstract: Gastrokine 1 (GKN1) protects the gastric antral mucosa and promotes healing by facilitating restitution and proliferation after injury. GKN1 is down-regulated in Helicobacter pylori-infected gastric epithelial cells and loss of GKN1 expression is tightly associated with gastric carcinogenesis. However, the underlying mechanisms as a tumor suppressor are largely unknown. Presently, the hydrophobic region and BRICHOS domain of GKN1, pGKN1{sup D13N}, pGKN1{sup Δ68–199}, and pGKN1{sup Δ1–67,165–199} weremore » shown to suppress gastric cancer cell growth and recapitulate GKN1 functions. As well, the hydrophobic region and BRICHOS domain of GKN1 had a synergistic anti-cancer effect with 5-FU on tumor cell growth, implying that the NH{sub 2}-terminal hydrophobic region and BRICHOS domain of GKN1 are sufficient for tumor suppression, thereby suggesting a therapeutic intervention for gastric cancer. Also, its domain inducing endogenous miR-185 directly targeted the epigenetic effectors DNMT1 and EZH2 in gastric cancer cells. Our results suggest that the NH{sub 2}-terminal hydrophobic region and BRICHOS domain of GKN1 are sufficient for its tumor suppressor activities.« less

10 CFR 1.5 - Location of principal offices and Regional Offices.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Location of principal offices and Regional Offices. 1.5 Section 1.5 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.5 Location of principal offices and Regional Offices. (a) The principal NRC offices are located in the Washington, DC, area. Facilities...

Region-specific deletions of RIM1 reproduce a subset of global RIM1α−/− phenotypes

PubMed Central

Haws, M E; Kaeser, P S; Jarvis, D L; Südhof, T C; Powell, C M

2012-01-01

The presynaptic protein RIM1α mediates multiple forms of presynaptic plasticity at both excitatory and inhibitory synapses. Previous studies of mice lacking RIM1α (RIM1α−/− throughout the brain showed that deletion of RIM1α results in multiple behavioral abnormalities. In an effort to begin to delineate the brain regions in which RIM1 deletion mediates these abnormal behaviors, we used conditional (floxed) RIM1 knockout mice (fRIM1). By crossing these fRIM1 mice to previously characterized transgenic cre lines, we aimed to delete RIM1 selectively in the dentate gyrus (DG), using a specific preproopiomelanocortin promoter driving cre recombinase (POMC-cre) line , and in pyramidal neurons of the CA3 region of hippocampus, using the kainate receptor subunit 1 promoter driving cre recombinase (KA-cre). Neither of these cre driver lines was uniquely selective to the targeted regions. In spite of this, we were able to reproduce a subset of the global RIM1α−/− behavioral abnormalities, thereby narrowing the brain regions in which loss of RIM1 is sufficient to produce these behavioral differences. Most interestingly, hypersensitivity to the pyschotomimetic MK-801 was shown in mice lacking RIM1 selectively in the DG, arcuate nucleus of the hypothalamus and select cerebellar neurons, implicating novel brain regions and neuronal subtypes in this behavior. PMID:22103334

Regional variations in the presentation and surgical management of Pierre Robin sequence.

PubMed

Scott, Andrew R; Mader, Nicholas S

2014-12-01

To estimate the current birth prevalence of isolated and syndromic Pierre Robin sequence (iPRS and sPRS), including demographic variations. To assess for regional variations in surgical airway interventions for PRS, and to determine the mean length of stay (LOS), cost of admission, complication rate, and rate of associated procedures related to tongue-lip adhesion (TLA), neonatal mandibular distraction osteogenesis (MDO), and tracheotomy. Retrospective cross-sectional study. The 2006 and 2009 Kids Inpatient Databases were used to identify newborns and infants with PRS; analysis using cross tabulations and linear regression modeling was performed. In 2006 and 2009, the estimated birth prevalence of iPRS was 1.8:10,000 live births and sPRS 1.4:10,000 live births. The highest rate was in whites and the lowest in non-Hispanic blacks. There were 145 TLAs (36%), 176 MDOs (43%), and 85 tracheotomies (21%). The Northeast favored a TLA strategy; the Midwest favored MDO. The mean LOS for TLA was 24.5 days, MDO 36.7 days, tracheotomy (iPRS) 44.9 days, and tracheotomy (sPRS) 53.0 days. The birth prevalence of PRS may be higher than previously described, especially in whites. Surgical management strategies vary between regions. The overall cost of a TLA admission is lower than an MDO or tracheotomy admission, owing primarily to shorter LOS. This study was limited by not taking into account outpatient expenses (nursing care, monitoring) or need for further airway/feeding intervention over subsequent admissions. 2c. © 2014 The American Laryngological, Rhinological and Otological Society, Inc.

The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines

PubMed Central

Ruoho, Arnold E.; Chu, Uyen B.; Ramachandran, Subramaniam; Fontanilla, Dominique; Mavlyutov, Timur; Hajipour, Abdol R.

2015-01-01

The sigma-1 receptor is a 26 kDa endoplasmic reticulum resident membrane protein that has been shown to have chaperone activity in addition to its promiscuous binding to pharmacological agents. Ligand binding domain(s) of the sigma-1 receptor have been identified using the E. coli expressed and purified receptor protein and novel radioiodinated azido photoaffinity probes followed by pro-teolytic and chemical cleavage strategies. The outcome of these experiments indicates that the sigma-1 receptor ligand binding regions are formed primarily by juxtaposition of its second and third hydrophobic domains, regions where the protein shares considerable homology with the fungal enzyme, sterol isomerase that is essential for the biosynthesis of ergosterol. Data indicate that these hydrophobic steroid binding domain like (SBDL) regions on the sigma-1 receptor are likely to interact selectively with N-alkyl amines such as the endogenous sphingolipids and with synthetic N-alkylamines and N-aralkylamines derivatives. A proposed model for the sigma-1 receptor is presented. PMID:22288412

L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

PubMed

Erwin, Jennifer A; Paquola, Apuã C M; Singer, Tatjana; Gallina, Iryna; Novotny, Mark; Quayle, Carolina; Bedrosian, Tracy A; Alves, Francisco I A; Butcher, Cheyenne R; Herdy, Joseph R; Sarkar, Anindita; Lasken, Roger S; Muotri, Alysson R; Gage, Fred H

2016-12-01

The healthy human brain is a mosaic of varied genomes. Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosaicism by inserting L1 sequences into new locations of somatic cell genomes. Using a machine learning-based, single-cell sequencing approach, we discovered that somatic L1-associated variants (SLAVs) are composed of two classes: L1 retrotransposition insertions and retrotransposition-independent L1-associated variants. We demonstrate that a subset of SLAVs comprises somatic deletions generated by L1 endonuclease cutting activity. Retrotransposition-independent rearrangements in inherited L1s resulted in the deletion of proximal genomic regions. These rearrangements were resolved by microhomology-mediated repair, which suggests that L1-associated genomic regions are hotspots for somatic copy number variants in the brain and therefore a heritable genetic contributor to somatic mosaicism. We demonstrate that SLAVs are present in crucial neural genes, such as DLG2 (also called PSD93), and affect 44-63% of cells of the cells in the healthy brain.

Diorganosilacetylene-alt-diorganosilvinylene polymers and a process densifying porous silicon-carbide bodies

DOEpatents

Barton, Thomas J.; Ijadi-Maghsoodi, Sina; Pang, Yi

1994-05-17

The present invention provides linear organosilicon polymers including acetylene and vinylene moieties, and a process for their preparation. These diorganosilacetylene-alt-diorganosilvinylene linear polymers can be represented by the formula: --[--(R.sup.1)(R.sup.2)Si--C.tbd.C--(R.sup.3)(R.sup.4)Si--CH=CH--].sub.n-- , wherein n.gtoreq.2; and each R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, aryl, and aralkyl radicals. The polymers are soluble in organic solvents, air stable, and can be pulled into fibers or cast into films. They can be thermally converted into silicon carbide ceramic materials.

Diorganosilacetylene-alt-diorganosilvinylene polymers and a process of preparation

DOEpatents

Barton, Thomas J.; Ijadi-Maghsoodi, Sina; Pang, Yi

1995-10-10

The present invention provides linear organosilicon polymers including acetylene and vinylene moieties, and a process for their preparation. These diorganosilacetylene-alt-diorganosilvinylene linear polymers can be represented by the formula: --[--(R.sup.1)(R.sup.2)Si--C.tbd.C--(R.sup.3)(R.sup.4)Si--CH.dbd.CH--].sub .n --, wherein n.gtoreq.2; and each R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, aryl, and aralkyl radicals. The polymers are soluble in organic solvents, air stable, and can be pulled into fibers or cast into films. They can be thermally converted into silicon carbide ceramic materials.

10 CFR 960.3-1-3 - Regionality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for repository development after the site for the first repository has been recommended, the Secretary shall give due... repositories. Such consideration shall take into account the proximity of sites to locations at which waste is...

Analysis of the K1 capsule biosynthesis genes of Escherichia coli: definition of three functional regions for capsule production.

PubMed

Boulnois, G J; Roberts, I S; Hodge, R; Hardy, K R; Jann, K B; Timmis, K N

1987-06-01

Transposon and deletion analysis of the cloned K1 capsule biosynthesis genes of Escherichia coli revealed that approximately 17 kb of DNA, split into three functional regions, is required for capsule production. One block (region 1) is required for translocation of polysaccharide to the cell surface and mutations in this region result in the intracellular appearance of polymer indistinguishable on immunoelectrophoresis to that found on the surface of K1 encapsulated bacteria. This material was released from the cell by osmotic shock indicating that the polysaccharide was probably present in the periplasmic space. Insertions in a second block (region 2) completely abolished polymer production and this second region is believed to encode the enzymes for the biosynthesis and polymerisation of the K1 antigen. Addition of exogenous N-acetylneuraminic acid to one insertion mutant in this region restored its ability to express surface polymer as judged by K1 phage sensitivity. This insertion probably defines genes involved in biosynthesis of N-acetylneuraminic acid. Insertions in a third block (region 3) result in the intracellular appearance of polysaccharide with a very low electrophoretic mobility. The presence of the cloned K1 capsule biosynthesis genes on a multicopy plasmid in an E. coli K-12 strain did not increase the yields of capsular polysaccharide produced compared to the K1+ isolate from which the genes were cloned.

Structure and Function of the Intracellular Region of the Plexin-B1 Transmembrane Receptor*

PubMed Central

Tong, Yufeng; Hota, Prasanta K.; Penachioni, Junia Y.; Hamaneh, Mehdi B.; Kim, SoonJeung; Alviani, Rebecca S.; Shen, Limin; He, Hao; Tempel, Wolfram; Tamagnone, Luca; Park, Hee-Won; Buck, Matthias

2009-01-01

Members of the plexin family are unique transmembrane receptors in that they interact directly with Rho family small GTPases; moreover, they contain a GTPase-activating protein (GAP) domain for R-Ras, which is crucial for plexin-mediated regulation of cell motility. However, the functional role and structural basis of the interactions between the different intracellular domains of plexins remained unclear. Here we present the 2.4 Å crystal structure of the complete intracellular region of human plexin-B1. The structure is monomeric and reveals that the GAP domain is folded into one structure from two segments, separated by the Rho GTPase binding domain (RBD). The RBD is not dimerized, as observed previously. Instead, binding of a conserved loop region appears to compete with dimerization and anchors the RBD to the GAP domain. Cell-based assays on mutant proteins confirm the functional importance of this coupling loop. Molecular modeling based on structural homology to p120GAP·H-Ras suggests that Ras GTPases can bind to the plexin GAP region. Experimentally, we show that the monomeric intracellular plexin-B1 binds R-Ras but not H-Ras. These findings suggest that the monomeric form of the intracellular region is primed for GAP activity and extend a model for plexin activation. PMID:19843518

Faint Debris Detection by Particle Based Track-Before-Detect Method

NASA Astrophysics Data System (ADS)

Uetsuhara, M.; Ikoma, N.

2014-09-01

This study proposes a particle method to detect faint debris, which is hardly seen in single frame, from an image sequence based on the concept of track-before-detect (TBD). The most widely used detection method is detect-before-track (DBT), which firstly detects signals of targets from single frame by distinguishing difference of intensity between foreground and background then associate the signals for each target between frames. DBT is capable of tracking bright targets but limited. DBT is necessary to consider presence of false signals and is difficult to recover from false association. On the other hand, TBD methods try to track targets without explicitly detecting the signals followed by evaluation of goodness of each track and obtaining detection results. TBD has an advantage over DBT in detecting weak signals around background level in single frame. However, conventional TBD methods for debris detection apply brute-force search over candidate tracks then manually select true one from the candidates. To reduce those significant drawbacks of brute-force search and not-fully automated process, this study proposes a faint debris detection algorithm by a particle based TBD method consisting of sequential update of target state and heuristic search of initial state. The state consists of position, velocity direction and magnitude, and size of debris over the image at a single frame. The sequential update process is implemented by a particle filter (PF). PF is an optimal filtering technique that requires initial distribution of target state as a prior knowledge. An evolutional algorithm (EA) is utilized to search the initial distribution. The EA iteratively applies propagation and likelihood evaluation of particles for the same image sequences and resulting set of particles is used as an initial distribution of PF. This paper describes the algorithm of the proposed faint debris detection method. The algorithm demonstrates performance on image sequences acquired

Artic and subarctic environmental analyses utilizing ERTS-1 imagery. Cold regions environmental analysis based on ERTS-1 imagery (preprint)

NASA Technical Reports Server (NTRS)

Anderson, D. M. (Principal Investigator); Haugen, R. K.; Gatto, L. W.; Slaughter, C. W.; Marlar, T. L.; Mckim, H. L.

1972-01-01

There are no author-identified significant results in this report. An overriding problem in arctic and subarctic environmental research has been the absence of long-term observational data and the sparseness of geographical coverage of existing data. A first look report is presented on the use of ERTS-1 imagery as a major tool in two large area environmental studies: (1) investigation of sedimentation and other nearshore marine processes in Cook Inlet, Alaska; and (2) a regional study of permafrost regimes in the discontinuous permafrost zone of Alaska. These studies incorporate ground truth acquisition techniques that are probably similar to most ERTS investigations. Studies of oceanographic processes in Cook Inlet will be focused on seasonal changes in nearshore bathymetry, tidal and major current circulation patterns, and coastal sedimentation processes, applicable to navigation, construction, and maintenance of harbors. Analyses will be made of the regional permafrost distribution and regimes in the Upper Koyukuk-Kobuk River area located in NW Alaska.

SOAR: Showcasing Outstanding Achievements in Region 1.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Workforce Development.

This document showcases 129 exemplary workforce development-related programs at elementary schools, middle schools, high schools, adult centers, school districts, vocational-technical centers, and two- and four-year colleges in 15 counties in Florida's western panhandle region. The 15 counties are: (1) Bay; (2) Calhoun; (3) Escambia; (4) Franklin;…

15-year incidence of diabetic ketoacidosis at onset of type 1 diabetes in children from a regional setting (Auckland, New Zealand).

PubMed

Jefferies, Craig; Cutfield, Samuel W; Derraik, José G B; Bhagvandas, Jignal; Albert, Benjamin B; Hofman, Paul L; Gunn, Alistair J; Cutfield, Wayne S

2015-05-19

We assessed the incidence of diabetic ketoacidosis (DKA) in children aged <15 years with newly diagnosed type 1 diabetes mellitus (T1DM) in the Auckland Region (New Zealand) in 1999-2013, in a retrospective review of a complete regional cohort. DKA and its severity were classified according to ISPAD 2014 guidelines. Of 730 children presenting with new-onset T1DM over the 15-year time period, 195 cases had DKA of any severity (27%). There was no change in the incidence of DKA or the proportion of children with severe DKA at presentation. The incidence of DKA among children aged <2.0 years (n = 40) was 53% compared to 25% for those aged 2-14 years (n = 690; p = 0.005). In children aged 2-14 years, increasing age at diagnosis was associated with greater likelihood of DKA at presentation (p = 0.025), with the odds of DKA increasing 1.06 times with each year increase in age. Non-Europeans were more likely to present in DKA than New Zealand Europeans (OR 1.52; p = 0.048). Despite a consistent secular trend of increasing incidence of T1DM, there was no reduction in the incidence of DKA in new-onset T1DM in the Auckland Region over time. Thus, it is important to explore ways to reduce DKA risk.

An empirical spectroscopic database for acetylene in the regions of 5850-6341 cm-1 and 7000-9415 cm-1

NASA Astrophysics Data System (ADS)

Lyulin, O. M.; Campargue, A.

2017-12-01

Six studies have been recently devoted to a systematic analysis of the high-resolution near infrared absorption spectrum of acetylene recorded by Cavity Ring Down spectroscopy (CRDS) in Grenoble and by Fourier-transform spectroscopy (FTS) in Brussels and Hefei. On the basis of these works, in the present contribution, we construct an empirical database for acetylene in the 5850-9415 cm-1 region excluding the 6341-7000 cm-1 interval corresponding to the very strong ν1+ν3 manifold. Our database gathers and extends information included in our CRDS and FTS studies. In particular, the intensities of about 1700 lines measured by CRDS in the 7244-7920 cm-1 region are reported for the first time together with those of several bands of 12C13CH2 present in natural isotopic abundance in the acetylene sample. The Herman-Wallis coefficients of most of the bands are derived from a fit of the measured intensity values. A recommended line list is provided with positions calculated using empirical spectroscopic parameters of the lower and upper energy vibrational levels and intensities calculated using the derived Herman-Wallis coefficients. This approach allows completing the experimental list by adding missing lines and improving poorly determined positions and intensities. As a result the constructed line list includes a total of 11113 transitions belonging to 150 bands of 12C2H2 and 29 bands of 12C13CH2. For comparison the HITRAN database in the same region includes 869 transitions of 14 bands, all belonging to 12C2H2. Our weakest lines have an intensity on the order of 10-29 cm/molecule, about three orders of magnitude smaller than the HITRAN intensity cut off. Line profile parameters are added to the line list which is provided in HITRAN format. The comparison of the acetylene database to the HITRAN2012 line list or to results obtained using the global effective operator approach is discussed in terms of completeness and accuracy.

The development of electrical treeing in LDPE and its nanocomposites with spherical silica and fibrous and laminar silicates

NASA Astrophysics Data System (ADS)

Tiemblo, Pilar; Hoyos, Mario; Gómez-Elvira, Jose Manuel; Guzmán, Julio; García, Nuria; Dardano, Andrea; Guastavino, Francesco

2008-06-01

Electrical treeing in LDPE and three LDPE nanocomposites, with spherical silica and fibrous and laminar phyllosilicates, has been studied. Electrical tests were performed at a 50 Hz frequency and voltages between 8 and 29 kV, and the time to inception of the first electrical partial discharges (TTI) of the electrical trees and the time to breakdown (TBD), related to the electrical stability of the insulator, were determined. Above 15 kV all the nanocomposites show longer inception times and shorter tree growth times than LDPE. It is proposed that both observations are caused by the modification of the polymer crystalline morphology induced by the presence of the fillers and by the development of a large number of interfacial structures, both organo-inorganic and amorphous-crystalline. Below 15 kV the TBD is increased in the nanocomposites with the laminar silicate because of tortuosity and the TTI is increased in the fibrous silicate containing a nanocomposite because of the LDPE crystalline morphology in the presence of the silicate. The nanosilica particles decrease the electrical stability in the whole voltage range by decreasing both TTI and TBD.

L1-Associated Genomic Regions are Deleted in Somatic Cells of the Healthy Human Brain

PubMed Central

Erwin, Jennifer A.; Paquola, Apuã C.M.; Singer, Tatjana; Gallina, Iryna; Novotny, Mark; Quayle, Carolina; Bedrosian, Tracy; Ivanio, Francisco; Butcher, Cheyenne R.; Herdy, Joseph R.; Sarkar, Anindita; Lasken, Roger S.; Muotri, Alysson R.; Gage, Fred H.

2016-01-01

The healthy human brain is a mosaic of varied genomes. L1 retrotransposition is known to create mosaicism by inserting L1 sequences into new locations of somatic cell genomes. Using a machine learning-based, single-cell sequencing approach, we discovered that Somatic L1-Associated Variants (SLAVs) are actually composed of two classes: L1 retrotransposition insertions and retrotransposition-independent L1-associated variants. We demonstrate that a subset of SLAVs are, in fact, somatic deletions generated by L1 endonuclease cutting activity. Retrotransposition- independent rearrangements within inherited L1s resulted in the deletion of proximal genomic regions. These rearrangements were resolved by microhomology-mediated repair, which suggests that L1-associated genomic regions are hotspots for somatic copy number variants in the brain and therefore a heritable genetic contributor to somatic mosaicism. We demonstrate that SLAVs are present in crucial neural genes, such as DLG2/PSD93, and affect between 44–63% of cells of the cells in the healthy brain. PMID:27618310

Regional chromosomal localisation of APOA2 to 1q21-1q23.

PubMed

Middleton-Price, H R; van den Berghe, J A; Scott, J; Knott, T J; Malcolm, S

1988-07-01

Using in situ hybridisation, we have mapped APOA2 to the 1q21-1q23 region of chromosome 1. DNA hybridisation to somatic cell hybrids made from cells carrying a balanced translocation between X and 1 confirms the localisation as proximal to 1q23. This was further confirmed by the presence of two polymorphic alleles in a cell line carrying a deletion of 1q25-1q32.

Postsynaptic density protein (PSD)-95 expression is markedly decreased in the hippocampal CA1 region after experimental ischemia-reperfusion injury.

PubMed

Yan, Bing Chun; Park, Joon Ha; Ahn, Ji Hyeon; Lee, Jae-Chul; Won, Moo-Ho; Kang, Il-Jun

2013-07-15

Synaptic plasticity is important for functional recovery after cerebral ischemic injury. In the present study, we investigated chronological change in the immunoreactivity of PSD-95, a kind of postsynaptic density protein, in the hippocampus proper (CA1-3 regions) after 5 min of transient cerebral ischemia in gerbils. PSD-95 immunoreactivity was observed in MAP-2-immunoreactive dendrites in the CA1-3 regions of the sham group. The PSD-95 immunoreactivity was shown as beaded structure in the MAP-2-immunoreactive dendrites. However, PSD-95 immunoreactivity began to be dramatically decreased in MAP-2-immunoreactive dendrites in the CA1 region, not CA2-3 region, at early time after ischemia-reperfusion. At 5 days after ischemia-reperfusion, MAP-2 immunoreactivity almost disappeared in the ischemic CA1 region, and PSD-95 immunoreactivity was much lower than that in the sham group. In brief, PSD-95 immunoreactivity in the CA1 dendrites was markedly decreased at early time after ischemia-reperfusion. We suggest that decreased PSD-95 immunoreactivity in the ischemic CA1 region may lead to a deficit of postsynaptic plasticity in the brain. Copyright © 2013 Elsevier B.V. All rights reserved.

Webinar Presentation: Linking Regional Aerosol Emission Changes with Multiple Impact Measures through Direct and Cloud-Related Forcing Estimates

EPA Pesticide Factsheets

This presentation, Linking Regional Aerosol Emission Changes with Multiple Impact Measures through Direct and Cloud-Related Forcing Estimates, was given at the STAR Black Carbon 2016 Webinar Series: Accounting for Impact, Emissions, and Uncertainty.

A novel class of Pseudoautosomal region 1 deletions downstream of SHOX is associated with Leri-Weill dyschondrosteosis.

PubMed

Benito-Sanz, Sara; Thomas, N Simon; Huber, Céline; Huber, Celine; Gorbenko del Blanco, Darya; Del Blanco, Darya Gorbenko; Aza-Carmona, Miriam; Crolla, John A; Maloney, Vivienne; Rappold, Gudrun; Argente, Jesús; Argente, Jesus; Campos-Barros, Angel; Cormier-Daire, Valérie; Cormier-Daire, Valerie; Heath, Karen E

2005-10-01

Leri-Weill dyschondrosteosis (LWD) is a pseudoautosomal dominant disorder characterized by disproportionate short stature and a characteristic curving of the radius, known as the "Madelung deformity." SHOX mutations resulting in SHOX haploinsufficiency have been found in LWD and in a variable proportion of patients with idiopathic short stature (ISS), whereas homozygous loss of SHOX results in the more severe Langer mesomelic dysplasia (LMD). Defects in SHOX have been identified in approximately 60% of LWD cases, whereas, in the remaining approximately 40%, the molecular basis is unknown. This suggests either genetic heterogeneity or the presence of mutations in unanalyzed regions of SHOX, such as the upstream, intragenic, or downstream regulatory sequences. Therefore, the pseudoautosomal region 1 (PAR1) of 80 patients with LWD, in whom SHOX deletions and mutations had been excluded, was screened for deletions by use of a new panel of microsatellite markers. We identified 12 patients with LWD who presented with a novel class of PAR1 deletions that did not include SHOX. The deletions were of variable size and mapped at least approximately 30-530 kb downstream of SHOX. In our cohort, this type of deletion accounted for 15% of cases. In all cases, the deletions cosegregated with the phenotype. No apparent phenotypic differences were observed between patients with SHOX deletions and those with this new class of PAR1 deletions. Thus, we present here the identification of a second PAR1 region implicated in the etiopathogenesis of LWD. Our findings suggest the presence of distal regulatory elements of SHOX transcription in PAR1 or, alternatively, the existence of an additional locus apparently involved in the control of skeletal development. Deletion analysis of this newly identified region should be included in the mutation screening of patients with LWD, LMD, and ISS.

Low-acuity presentations to the emergency department in Canada: exploring the alternative attempts to avoid presentation.

PubMed

Krebs, Lynette D; Kirkland, Scott W; Chetram, Rajiv; Nikel, Taylor; Voaklander, Britt; Davidson, Alan; Holroyd, Bryn; Villa-Roel, Cristina; Crick, Katelynn; Couperthwaite, Stephanie; Alexiu, Chris; Cummings, Garnet; Rowe, Brian H

2017-04-01

ED visits have been rising year on year worldwide. It has been suggested that some of these visits could be avoided if low-acuity patients had better primary care access. This study explored patients' efforts to avoid ED presentation and alternative care sought prior to presentation. Consecutive adult patients presenting to three urban EDs in Edmonton, Canada, completed a questionnaire collecting demographics, actions attempted to avoid presentation and reasons for presentation. Survey data were cross-referenced to a minimal patient dataset containing ED and demographic information. A total of 1402 patients (66.5%) completed the survey. Although 89.3% of the patients felt that the ED was their best care option, the majority of patients (60.1%) sought alternative care or advice prior to presentation. Men, individuals who presented with injury only, and individuals with less than a high school education were all less likely to seek alternative care. Alternative care actions included visiting a physician (54.1%) or an alternative healthcare professional (eg, chiropractor, physiotherapist, etc; 21.2%), calling physician offices (47%) or the regional health information line (13%). Of those who called their physicians, the majority received advice to present to the ED (67.5%). Most low-acuity patients attempt to avoid ED presentation by seeking alternative care. This analysis identifies groups of individuals in the study region who are less likely to seek alternative care first and may benefit from targeted interventions/education. Other regions may wish to complete a similar profile to determine which patients are less likely to seek alternative care first. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

ISOLATION OF THE REGULATORY REGIONS AND GENOMIC ORGANIZATION OF THE PORCINE α1,3-GALACTOSYLTRANSFERASE GENE1

PubMed Central

Koike, Chihiro; Friday, Robert P.; Nakashima, Izumi; Luppi, Patrizia; Fung, John J.; Rao, Abdul S.; Starzl, Thomas E.; Trucco, Massimo

2010-01-01

Background α1,3-galactosyltransferase (α1,3GT) is an enzyme that produces carbohydrate chains termed αGal epitopes found in most mammals, although some species of higher primates, including human, are notable exceptions. The evolutionary origin of the lost α1,3GT enzyme activity is not yet known, although it has been suggested that the promoter activity of this gene in the ancestors of higher primates was inactivated. Methods We used 5′-or 3′-RACE, GenomeWalking, reverse transcriptase polymerase chain reaction (RT-PCR) and dual Luciferase reporter assay for identification of the full-length cDNA, which includes the transcription initiation site and the promoter region of porcine α1,3GT gene. Results The region around exon 1 is guanine and cytosine (GC)-rich (about 70%), comprising a CpG island spanning more than 1.5 kbp. The 5′-flanking region of exon 1 contains multiple transcription factor consensus motifs, including GC-box, SP1, AP2, and GATA-box sites, in the absence of TATA or CAAT-box sequences. The entire gene consists of three 5′ noncoding and six coding region exons spanning more than 52 kbp. Detailed analysis of α1,3GT transcripts revealed two major alternative splicing patterns in the 5′-untranslated region (5′-UTR) and evidence for minor splicing activity that occurs in a tissue-specific manner. Interspecies comparison of 5′-UTR shows minimal homology between porcine and murine sequences except for exon 2, which suggests that the regulatory regions differ among species. Conclusions These observations have important implications for experiments involving genetic manipulation of the α1,3GT gene in transgenic animals in terms of promoter utilization, and particularly in genetically engineering cells for the animal cloning technology by nuclear transfer. PMID:11087141

The σ70 region 1.2 regulates promoter escape by unwinding DNA downstream of the transcription start site

PubMed Central

Bochkareva, Aleksandra; Zenkin, Nikolay

2013-01-01

The mechanisms of abortive synthesis and promoter escape during initiation of transcription are poorly understood. Here, we show that, after initiation of RNA synthesis, non-specific interaction of σ70 region 1.2, present in all σ70 family factors, with the non-template strand around position −4 relative to the transcription start site facilitates unwinding of the DNA duplex downstream of the transcription start site. This leads to stabilization of short RNA products and allows their extension, i.e. promoter escape. We show that this activity of σ70 region 1.2 is assisted by the β-lobe domain, but does not involve the β′-rudder or the β′-switch-2, earlier proposed to participate in promoter escape. DNA sequence independence of this function of σ70 region 1.2 suggests that it may be conserved in all σ70 family factors. Our results indicate that the abortive nature of initial synthesis is caused, at least in part, by failure to open the downstream DNA by the β-lobe and σ region 1.2. PMID:23430153

Circumnuclear Regions In Barred Spiral Galaxies. 1; Near-Infrared Imaging

NASA Technical Reports Server (NTRS)

Perez-Ramirez, D.; Knapen, J. H.; Peletier, R. F.; Laine, S.; Doyon, R.; Nadeau, D.

2000-01-01

We present sub-arcsecond resolution ground-based near-infrared images of the central regions of a sample of twelve barred galaxies with circumnuclear star formation activity, which is organized in ring-like regions typically one kiloparsec in diameter. We also present Hubble Space Telescope near-infrared images of ten of our sample galaxies, and compare them with our ground-based data. Although our sample galaxies were selected for the presence of circumnuclear star formation activity, our broad-band near-infrared images are heterogeneous, showing a substantial amount of small-scale structure in some galaxies, and practically none in others. We argue that, where it exists, this structure is caused by young stars, which also cause the characteristic bumps or changes in slope in the radial profiles of ellipticity, major axis position angle, surface brightness and colour at the radius of the circumnuclear ring in most of our sample galaxies. In 7 out of 10 HST images, star formation in the nuclear ring is clearly visible as a large number of small emitting regions, organised into spiral arm fragments, which are accompanied by dust lanes. NIR colour index maps show much more clearly the location of dust lanes and, in certain cases, regions of star formation than single broad-band images. Circumnuclear spiral structure thus outlined appears to be common in barred spiral galaxies with circumnuclear star formation.

Functional Analysis of Promoter Region from Eel Cytochrome P450 1A1 Gene in Transgenic Medaka.

PubMed

Ogino; Itakura; Kato; Aoki; Sato

1999-07-01

: Transcription of the CYP1A1 genes in mammals and fish is stimulated by polyaromatic hydrocarbons. DNA sequencing analysis revealed that CYP1A1 gene in eel (Anguilla japonica) contains two kinds of putative cis-acting regulatory elements, XRE (xenobiotic-responsive element) and ERE (estrogen-responsive element). XRE is known as the enhancer that is responsible for the inducibility of the genes of CYP1A1 and some other drug-metabolizing enzymes. In the eel CYP1A1 gene, XRE motifs are distributed as follows: five times in the region from -2136 to -1125 bp, XRE(-6) to (-2); once in the proximal basal promoter region, XRE(-1); and once in the first intron, XRE(+1). The region between XRE(-2) and XRE(-1) contains three ERE motifs. To investigate the function of the cis-acting regulatory elements in the eel CYP1A1 gene, recombinant plasmids prepared with its 5' upstream sequence and the structural gene for luciferase were microinjected into fertilized eggs of medaka at the one-cell stage. Hatched fry were treated with 3-methylcholanthrene, and the transcription efficiency was assayed using competitive polymerase chain reaction analysis. Deletion of the region containing the five XREs, XRE(-6) to XRE(-2), and the point mutation of XRE(-1) reduced the inducible expressions by 75% and 56%, respectively, showing apparent dependency of the drug induction on the XREs. Constitutive expression, however, was not significantly affected by deletion or disruption of the XREs. When the region between XRE(-2) and XRE(-1) containing no XREs but three ERE motifs was internally deleted, the inducible expression and the constitutive expression were reduced by 88% and 75%, respectively. Replacement of this region with a partial fragment of eel CYP1A1 complementary DNA, with slight alteration of the distance between the five XREs and XRE(-1), reduced the inducible expression and the constitutive expression by 91% and 60%, respectively. These results strongly suggest that not only XRE but

The Present Situation, Problems, Countermeasures of Compulsory Education in the Rural Area of Western Region in China

ERIC Educational Resources Information Center

Xu, Hui

2005-01-01

The present condition of rural education in the western region of China is not optimistic. Existing problems include lacking education investment, poor school-running conditions, simplified running pattern and laggard concept of education. The countermeasures are: firstly, governments at all level especially the center one should increase input to…

Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells

PubMed Central

Roy, Sobhan; Ly, Dalam; Li, Nan-Sheng; Altman, John D.; Piccirilli, Joseph A.; Moody, D. Branch; Adams, Erin J.

2014-01-01

CD1c is a member of the group 1 CD1 family of proteins that are specialized for lipid antigen presentation. Despite high cell surface expression of CD1c on key antigen-presenting cells and the discovery of its mycobacterial lipid antigen presentation capability, the molecular basis of CD1c recognition by T cells is unknown. Here we present a comprehensive functional and molecular analysis of αβ T-cell receptor (TCR) recognition of CD1c presenting mycobacterial phosphomycoketide antigens. Our structure of CD1c with the mycobacterial phosphomycoketide (PM) shows similarities to that of CD1c-mannosyl-β1-phosphomycoketide in that the A' pocket accommodates the mycoketide alkyl chain; however, the phosphate head-group of PM is shifted ∼6 Å in relation to that of mannosyl-β1-PM. We also demonstrate a bona fide interaction between six human TCRs and CD1c-mycoketide complexes, measuring high to moderate affinities. The crystal structure of the DN6 TCR and mutagenic studies reveal a requirement of five complementarity determining region (CDR) loops for CD1c recognition. Furthermore, mutagenesis of CD1c reveals residues in both the α1 and α2 helices involved in TCR recognition, yet not entirely overlapping among the examined TCRs. Unlike patterns for MHC I, no archetypical binding footprint is predicted to be shared by CD1c-reactive TCRs, even when recognizing the same or similar antigens. PMID:25298532

Differentiation regional climate impact indicators at 1.5°C and 2°C warming above pre-industrial levels

NASA Astrophysics Data System (ADS)

Schleussner, C. F.

2016-12-01

Robust appraisals of climate impacts at different levels of global-mean temperature increase are vital to guide assessments of dangerous anthropogenic interference with the climate system. By establishing 1.5°C as the long term temperature limit for global average temperature increase and inviting a special report of the IPCC on the impacts of 1.5°C, the Paris Agreement has put such assessments high on the post-Paris science agenda. Here I will present recent findings of climate impacts at 1.5°C, including extreme weather events, water availability, agricultural yields, sea-level rise and risk of coral reef loss. In particular, I will present findings from a recent study that attempts to differentiate between such impacts at warming levels of 1.5°¸C and 2°C above pre-industrial (Schleussner et al., 2016). By analyzing changes in indicators for 26 world regions as applicable, the study found regional dependent differences between a 1.5°C and 2°C warming. Regional hot-spots of change emerge with tropical regions bearing the brunt of the impacts of an additional 0.5°C warming. These findings highlight the importance of regional differentiation to assess both future climate risks and different vulnerabilities to incremental increases in global-mean temperature. Building on that analysis, I will discuss limitations of existing approaches to differentiate between warming levels and outline opportunities for future work on refining our understanding of the difference between impacts at 1.5°C and 2°C warming. ReferencesSchleussner, C.-F. et al. Differential climate impacts for policy relevant limits to global warming: the case of 1.5°C and 2°C. Earth Syst. Dyn. 7, 327-351 (2016).

Altair Descent and Ascent Reference Trajectory Design and Initial Dispersion Analyses

NASA Technical Reports Server (NTRS)

Kos, Larry D.; Polsgrove, Tara T.; Sostaric, Ronald r.; Braden, Ellen M.; Sullivan, Jacob J.; Lee, Thanh T.

2010-01-01

The Altair Lunar Lander is the linchpin in the Constellation Program (CxP) for human return to the Moon. Altair is delivered to low Earth orbit (LEO) by the Ares V heavy lift launch vehicle, and after subsequent docking with Orion in LEO, the Altair/Orion stack is delivered through translunar injection (TLI). The Altair/Orion stack separating from the Earth departure stage (EDS) shortly after TLI and continues the flight to the Moon as a single stack. Altair performs the lunar orbit insertion (LOI) maneuver, targeting a 100-km circular orbit. This orbit will be a polar orbit for missions landing near the lunar South Pole. After spending nearly 24 hours in low lunar orbit (LLO), the lander undocks from Orion and performs a series of small maneuvers to set up for descending to the lunar surface. This descent begins with a small deorbit insertion (DOI) maneuver, putting the lander on an orbit that has a perilune of 15.24 km (50,000 ft), the altitude where the actual powered descent initiation (PDI) commences. At liftoff from Earth, Altair has a mass of 45 metric tons (mt). However after LOI (without Orion attached), the lander mass is slightly less than 33 mt at PDI. The lander currently has a single descent module main engine, with TBD lb(sub f) thrust (TBD N), providing a thrust-to-weight ratio of approximately TBD Earth g's at PDI. LDAC-3 (Lander design and analysis cycle #3) is the most recently closed design sizing and mass properties iteration. Upgrades for loss of crew (LDAC-2) and loss of mission (LDAC-3) have been incorporated into the lander baseline design (and its Master Equipment List). Also, recently, Altair has been working requirements analyses (LRAC-1). All nominal data here are from the LDAC-3 analysis cycle. All dispersions results here are from LRAC-1 analyses.

15-year incidence of diabetic ketoacidosis at onset of type 1 diabetes in children from a regional setting (Auckland, New Zealand)

PubMed Central

Jefferies, Craig; Cutfield, Samuel W.; Derraik, José G. B.; Bhagvandas, Jignal; Albert, Benjamin B.; Hofman, Paul L.; Gunn, Alistair J.; Cutfield, Wayne S.

2015-01-01

We assessed the incidence of diabetic ketoacidosis (DKA) in children aged <15 years with newly diagnosed type 1 diabetes mellitus (T1DM) in the Auckland Region (New Zealand) in 1999–2013, in a retrospective review of a complete regional cohort. DKA and its severity were classified according to ISPAD 2014 guidelines. Of 730 children presenting with new-onset T1DM over the 15-year time period, 195 cases had DKA of any severity (27%). There was no change in the incidence of DKA or the proportion of children with severe DKA at presentation. The incidence of DKA among children aged <2.0 years (n = 40) was 53% compared to 25% for those aged 2–14 years (n = 690; p = 0.005). In children aged 2–14 years, increasing age at diagnosis was associated with greater likelihood of DKA at presentation (p = 0.025), with the odds of DKA increasing 1.06 times with each year increase in age. Non-Europeans were more likely to present in DKA than New Zealand Europeans (OR 1.52; p = 0.048). Despite a consistent secular trend of increasing incidence of T1DM, there was no reduction in the incidence of DKA in new-onset T1DM in the Auckland Region over time. Thus, it is important to explore ways to reduce DKA risk. PMID:25989414

Orthopaedic Section Poster Presentations (Abstracts OPO1-OPO300).

PubMed

2018-01-01

These abstracts are presented here as prepared by the authors. The accuracy and content of each abstract remain the responsibility of the authors. In the identification number above each abstract, OPO designates an Orthopaedic Section poster presentation. J Orthop Sports Phys Ther 2018;48(1):A67-A202. doi:10.2519/jospt.2018.48.1.A67.

Gas kinematics in the H II regions G351.69-1.15 and G351.63-1.25

NASA Astrophysics Data System (ADS)

Veena, V. S.; Vig, S.; Tej, A.; Kantharia, N. G.; Ghosh, S. K.

2017-03-01

We probe the structure and kinematics of two neighbouring H II regions identified as cometary and bipolar, using radio recombination lines (RRLs). The H172α RRLs from these H II regions: G351.69-1.15 and G351.63-1.25, are mapped using Giant Metrewave Radio Telescope, India. We also detect carbon RRLs C172α towards both these regions. The hydrogen RRLs display the effects of pressure and dynamical broadening in the line profiles, with the dynamical broadening (∼15 km s-1) playing a major role in the observed profile of G351.69-1.15. We investigate the kinematics of molecular gas species towards this H II region from the Millimetre Astronomy Legacy Team 90 GHz Pilot Survey. The molecular gas is mostly distributed towards the north and north-west of the cometary head. The molecular line profiles indicate signatures of turbulence and outflow in this region. The ionized gas at the cometary tail is blueshifted by ∼8 km s-1 with respect to the ambient molecular cloud, consistent with the earlier proposed champagne flow scenario. The relative velocity of ∼5 km s-1 between the northern and southern lobes of the bipolar H II region G351.63-1.25 is consistent with the premise that the bipolar morphology is a result of the expanding ionized lobes within a flat molecular cloud.

TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region.

PubMed

Rossi, Valeria; Beffagna, Giorgia; Rampazzo, Alessandra; Bauce, Barbara; Danieli, Gian Antonio

2004-06-23

Isthmins represent a novel family of vertebrate secreted proteins containing one copy of the thrombospondin type 1 repeat (TSR), which in mammals is shared by several proteins with diverse biological functions, including cell adhesion, angiogenesis, and patterning of developing nervous system. We have determined the genomic organization of human TAIL1 (thrombospondin and AMOP containing isthmin-like 1), a novel isthmin-like gene encoding a protein that contains a TSR and a C-terminal AMOP domain (adhesion-associated domain in MUC4 and other proteins), characteristic of extracellular proteins involved in adhesion processes. TAIL1 gene encompasses more than 24.4 kb. Analysis of the DNA sequence surrounding the putative transcriptional start region revealed a TATA-less promoter located in a CpG island. Several consensus binding sites for the transcription factors Sp1 and MZF-1 were identified in this promoter region. In humans, TAIL1 gene is located on chromosome 14q24.3 within ARVD1 (arrhythmogenic right ventricular dysplasia/cardiomyopathy, type 1) critical region; preliminary evidence suggests that it is expressed in several tissues, showing multiple alternative splicing.

Present-Day Vegetation Helps Quantifying Past Land Cover in Selected Regions of the Czech Republic

PubMed Central

Abraham, Vojtěch; Oušková, Veronika; Kuneš, Petr

2014-01-01

The REVEALS model is a tool for recalculating pollen data into vegetation abundances on a regional scale. We explored the general effect of selected parameters by performing simulations and ascertained the best model setting for the Czech Republic using the shallowest samples from 120 fossil sites and data on actual regional vegetation (60 km radius). Vegetation proportions of 17 taxa were obtained by combining the CORINE Land Cover map with forest inventories, agricultural statistics and habitat mapping data. Our simulation shows that changing the site radius for all taxa substantially affects REVEALS estimates of taxa with heavy or light pollen grains. Decreasing the site radius has a similar effect as increasing the wind speed parameter. However, adjusting the site radius to 1 m for local taxa only (even taxa with light pollen) yields lower, more correct estimates despite their high pollen signal. Increasing the background radius does not affect the estimates significantly. Our comparison of estimates with actual vegetation in seven regions shows that the most accurate relative pollen productivity estimates (PPEs) come from Central Europe and Southern Sweden. The initial simulation and pollen data yielded unrealistic estimates for Abies under the default setting of the wind speed parameter (3 m/s). We therefore propose the setting of 4 m/s, which corresponds to the spring average in most regions of the Czech Republic studied. Ad hoc adjustment of PPEs with this setting improves the match 3–4-fold. We consider these values (apart from four exceptions) to be appropriate, because they are within the ranges of standard errors, so they are related to original PPEs. Setting a 1 m radius for local taxa (Alnus, Salix, Poaceae) significantly improves the match between estimates and actual vegetation. However, further adjustments to PPEs exceed the ranges of original values, so their relevance is uncertain. PMID:24936973

Towards Estimate of Present Day Ice Melting in Polar Regions From Altimetry, Gravity, Ocean Bottom Pressure and GPS Observations

NASA Astrophysics Data System (ADS)

Jiang, Y.; Wu, X.; van den Broeke, M. R.; Munneke, P. K.; Simonsen, S. B.; van der Wal, W.; Vermeersen, B. L.

2013-12-01

The ice sheet in Polar Regions stores the largest freshwater bodies on Earth, sufficient to elevate global sea level by more than 65 meters if melted. The earth may have entered an intensive ice-melting episode, possibly due to anthropogenic global warming rather than natural orbit variations. Determining present-day ice mass balance, however, is complicated by the fact that most observations contain both present day ice melting signal and residual signals from past glacier melting. Despite decades of progress in geodynamic modeling and new observations, significant uncertainties remain in both. The key to separate present-day ice mass change and signals from past melting is to include data of different physical characteristics. We conducted a new global kinematic inversion scheme to estimate both present-day ice melting and past glacier signatures simultaneously and assess their contribution to current and future global mean sea level change. Our approach is designed to invert and separate present-day melting signal in the spherical harmonic domain using a globally distributed interdisciplinary data with distinct physical information. Interesting results with unprecedented precisions have been achieved so far. We will present our results of the estimated present-day ice mass balance trend in both Greenland and Antarctica ice sheet as well as other regions where significant mass change occurs.

Mannitol induces selective astroglial death in the CA1 region of the rat hippocampus following status epilepticus

PubMed Central

Ko, Ah-Reum; Kang, Tae-Cheon

2015-01-01

In the present study, we addressed the question of whether treatment with mannitol, an osmotic diuretic, affects astrogliovascular responses to status epilepticus (SE). In saline-treated animals, astrocytes exhibited reactive astrogliosis in the CA1-3 regions 2-4 days after SE. In the mannitol-treated animals, a large astroglial empty zone was observed in the CA1 region 2 days after SE. This astroglial loss was unrelated to vasogenic edema formation. There was no difference in SE-induced neuronal loss between saline- and mannitol-treated animals. Furthermore, mannitol treatment did not affect astroglial loss and vasogenic edema formation in the dentate gyrus and the piriform cortex. These findings suggest that mannitol treatment induces selective astroglial loss in the CA1 region independent of vasogenic edema formation following SE. These findings support the hypothesis that the susceptibility of astrocytes to SE is most likely due to the distinctive heterogeneity of astrocytes independent of hemodynamics. [BMB Reports 2015; 48(9): 507-512] PMID:25703536

Genomic Anatomy of a Premier Major Histocompatibility Complex Paralogous Region on Chromosome 1q21–q22

PubMed Central

Shiina, Takashi; Ando, Asako; Suto, Yumiko; Kasai, Fumio; Shigenari, Atsuko; Takishima, Nobusada; Kikkawa, Eri; Iwata, Kyoko; Kuwano, Yuko; Kitamura, Yuka; Matsuzawa, Yumiko; Sano, Kazumi; Nogami, Masahiro; Kawata, Hisako; Li, Suyun; Fukuzumi, Yasuhito; Yamazaki, Masaaki; Tashiro, Hiroyuki; Tamiya, Gen; Kohda, Atsushi; Okumura, Katsuzumi; Ikemura, Toshimichi; Soeda, Eiichi; Mizuki, Nobuhisa; Kimura, Minoru; Bahram, Seiamak; Inoko, Hidetoshi

2001-01-01

Human chromosomes 1q21–q25, 6p21.3–22.2, 9q33–q34, and 19p13.1–p13.4 carry clusters of paralogous loci, to date best defined by the flagship 6p MHC region. They have presumably been created by two rounds of large-scale genomic duplications around the time of vertebrate emergence. Phylogenetically, the 1q21–25 region seems most closely related to the 6p21.3 MHC region, as it is only the MHC paralogous region that includes bona fide MHC class I genes, the CD1 and MR1 loci. Here, to clarify the genomic structure of this model MHC paralogous region as well as to gain insight into the evolutionary dynamics of the entire quadriplication process, a detailed analysis of a critical 1.7 megabase (Mb) region was performed. To this end, a composite, deep, YAC, BAC, and PAC contig encompassing all five CD1 genes and linking the centromeric +P5 locus to the telomeric KRTC7 locus was constructed. Within this contig a 1.1-Mb BAC and PAC core segment joining CD1D to FCER1A was fully sequenced and thoroughly analyzed. This led to the mapping of a total of 41 genes (12 expressed genes, 12 possibly expressed genes, and 17 pseudogenes), among which 31 were novel. The latter include 20 olfactory receptor (OR) genes, 9 of which are potentially expressed. Importantly, CD1, SPTA1, OR, and FCERIA belong to multigene families, which have paralogues in the other three regions. Furthermore, it is noteworthy that 12 of the 13 expressed genes in the 1q21–q22 region around the CD1 loci are immunologically relevant. In addition to CD1A-E, these include SPTA1, MNDA, IFI-16, AIM2, BL1A, FY and FCERIA. This functional convergence of structurally unrelated genes is reminiscent of the 6p MHC region, and perhaps represents the emergence of yet another antigen presentation gene cluster, in this case dedicated to lipid/glycolipid antigens rather than antigen-derived peptides. [The nucleotide sequence data reported in this paper have been submitted to the DDBJ, EMBL, and GenBank databases under

A Study of Enabling Factors for Rapid Fielding: Combined Practices to Balance Speed and Stability

DTIC Science & Technology

2013-05-01

as contributors to the success of Agile projects, such as Scrum status meetings, continuous integration, test-driven development, etc. A second...Management Approach Type Product Size Team Size Sprint length / Prod Release Cycle A-P1 Pre- release Scrum Case management system ᝺M...SLOC 10-20 2 weeks/ TBD B-P1 12 years Scrum Analysis support system ᝺M SLOC 10-20 2 weeks/ 6 months – 1 year C-P1 3 years Scrum Training

Thermal and albedo mapping of the polar regions of Mars using Viking thermal mapper observations: 1. North polar region

NASA Technical Reports Server (NTRS)

Paige, David A.; Bachman, Jennifer E.; Keegan, Kenneth D.

1994-01-01

We present the first maps of the apparent thermal inertia and albedo of the north polar region of Mars. The observations used to create these maps were acquired by the infrared thermal mapper (IRTM) instruments on the two Viking orbiters over a 50-day period in 1978 during the Martian early northern summer season. The maps cover the region from 60 deg N to the north pole at a spatial resolution of 1/2 deg of latitude. The analysis and interpretation of these maps is aided by the results of a one-dimensional radiative convective model, which is used to calculate diurnal variations in surface and atmospheric temperatures, and brightness temperatures at the top of the atmospphere for a wide range of assumptions concerning aerosol optical properties and aerosol optical depths. The results of these calculations show that the effects of the Martian atmosphere on remote determinations of surface thermal inertia are more significant than have been indicated in previous studies. The maps of apparent thermal inertia and albedo show a great deal of spatial structure that is well correlated with surface features.

A functional SNP in the promoter region of TCOF1 is associated with reduced gene expression and YY1 DNA-protein interaction.

PubMed

Masotti, Cibele; Armelin-Correa, Lucia M; Splendore, Alessandra; Lin, Chin J; Barbosa, Angela; Sogayar, Mari C; Passos-Bueno, Maria Rita

2005-10-10

Treacher Collins syndrome (TCS) is an autosomal dominant craniofacial malformation caused by null mutations in the TCOF1 gene. High inter and intra familial clinical variability, ranging from mild malar hypoplasia to perinatal death due to airway collapse is observed, but, to date, no genotype-phenotype correlation has been reported. Considering haploinsufficiency as the molecular mechanism underlying the disease, we have hypothesized that mutations in the promoter region of the gene, which has never been previously characterized, in trans with a pathogenic mutation, could modulate the phenotype. Therefore, the aims of the present study were to determine the TCOF1 gene's core promoter and to identify mutations in this region that could contribute to the phenotypic variation observed in this syndrome. We have delimitated the minimal promoter to a region of less than 150 bp, with 63% of identity among 5 different species. We screened 1.2 kbp of the TCOF1 5' flanking sequence in the DNA obtained from 21 patients and 51 controls and identified four new single nucleotide polymorphisms (SNPs), one of which (-346C>T), was proved to be functional, as it decreased the promoter activity by 38%. Electrophoretic mobility shift assay (EMSA) analysis demonstrated that the -346T allele impairs DNA-binding to the YY1 transcription factor. This promoter variant represents a candidate allele to explain the clinical variability in patients bearing TCS.

Termination of atrial spiral waves by traction into peripheral non 1:1 conducting regions - A numerical study.

PubMed

Rozner, Amit; Zlochiver, Sharon

2016-11-01

Atrial ablation has been recently utilized to treat atrial fibrillation (AF) by isolation or destruction of arrhythmia drivers. In chronic or persistent AF patients these drivers often consist of one or few rotors at unknown locations, and several ablations are commonly conducted before arrhythmia is terminated. However, the irreversible damage done to the tissue may lead to AF recurrence. We propose an alternative strategy to terminate rotor activity by its attraction into a non 1:1 conducting region. The feasibility of the method was numerically tested in 2D models of chronic AF human atrial tissue. Left-to-right gradients of either acetylcholine (ACh) or potassium conductance were employed to generate regions of 1:1 and non 1:1 conduction, characterized by their dominant frequency (DF) ratios. Spiral waves were established in the 1:1 conducting region and raster scanning was employed using a stimulating probe to attract the spiral wave tip. The probe was then linearly moved towards the boundary between the two regions. Successful attraction of spiral waves to the probe was demonstrated when the probe was <8mm from the spiral wave tip. Maximal traction velocity without loss of anchoring increased in a non-linear way with increasing values of ACh. Success rate of spiral wave termination was over 90% for regional DF ratios of as low as 1:1.2. Given that normally much higher ratios are measured in physiological atrial tissues, we envision this technique to provide a feasible, safer alternative to ablation procedures performed in persistent AF patients. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

Interleukin 1 Receptor Antagonist Deficiency Presenting as Infantile Pustulosis Mimicking Infantile Pustular Psoriasis

PubMed Central

Minkis, Kira; Aksentijevich, Ivona; Goldbach-Mansky, Raphaela; Magro, Cynthia; Scott, Rachelle; Davis, Jessica G.; Sardana, Niti; Herzog, Ronit

2012-01-01

Background Deficiency of interleukin 1 receptor antagonist (DIRA) is a recently described autoinflammatory syndrome of skin and bone caused by recessive mutations in the gene encoding the interleukin 1 receptor antagonist. Few studies have been published about this debilitating condition. Early identification is critical for targeted lifesaving intervention. Observations A male infant, born to nonconsanguineous Puerto Rican parents, was referred for management of a pustular eruption diagnosed as pustular psoriasis. At 2 months of age, the infant developed a pustular eruption. After extensive evaluation, he was confirmed to be homozygous for a 175-kb genomic deletion on chromosome 2 that includes the IL1RN gene, commonly found in Puerto Ricans. Therapy with anakinra was initiated, with rapid clearance of skin lesions and resolution of systemic inflammation. Conclusions Recent identification of DIRA as a disease entity, compounded by the limited number of reported cases, makes early identification difficult. It is critical to consider this entity in the differential diagnosis of infantile pustulosis. Targeted therapy with the recombinant human interleukin 1 receptor antagonist anakinra can be lifesaving if initiated early. A high carrier frequency of the 175-kb DIRA-associated genomic deletion in the Puerto Rican population strongly supports testing infants presenting with unexplained pustulosis in patients from this geographic region. PMID:22431714

Neurofibromatosis type 1 with external genitalia involvement presentation of 4 patients.

PubMed

Pascual-Castroviejo, Ignacio; Lopez-Pereira, Pedro; Savasta, Salvatore; Lopez-Gutierrez, Juan Carlos; Lago, Carlos Míguelez; Cisternino, Mariangela

2008-11-01

Genitourinary neurofibromas with clitoral involvement in neurofibromatosis type 1 are rare, and even more infrequent are the neurofibromas involving genitalia in males. The most frequent presenting sign of neurofibroma in females is clitoromegaly with pseudopenis, and enlarged penis is the most common sign in males. Labium majus neurofibroma not associated with clitoral involvement is extremely rare. Magnetic resonance imaging demonstration of the neurofibromas has seldom been reported. We report 4 children, 3 girls and 1 boy, with plexiform neurofibromas involving the external genitalia. Three of the 4 patients had histologic confirmation of neurofibroma. Two girls with clitoral hypertrophy had a neurofibroma that infiltrated the clitoris and extended unilaterally to the lower bladder wall. One girl had a plexiform neurofibroma that affected a labium. One boy with asymmetric penile hypertrophy since 2 years of age and ipsilateral gluteal hypertrophy had plexiform neurofibromas that extended between the left lumbogluteal and penile regions, infiltrating the left rectum wall and bladder with compression of both structures, the left prostate, and the left half of the cavernous corpi with hypertrophy of this part and asymmetry of the penis. Magnetic resonance imaging demonstrated in all patients that external genitalia and plexiform neurofibroma formed images of nondetachable structures. However, hermaphroditism was discarded by chromosomal study in all 3 girls before ratifying the diagnosis of external genitalia neurofibroma.

High Velocity Firings of Slug Projectiles in a Double-Travel 120-MM Gun System

DTIC Science & Technology

1991-04-01

constraints presented by TBD. This charge configuration was then tested using aluminium slug projectiles to avoid the unnecessary expenditure of APFSDS...test projectile was a depleted uranium alloy (U-.75Ti) rod with a standard, four piece, aluminum sabot assembly. The launch package had a nominal...the rod is shown in Figure 2. Figure 2. Scaled, Long Rod Penetrator. Figure 3. Aluminium Slug Projectile. The aluminium slug rounds, fired at Range 18

Timeline trend profile and seasonal variations in nicotine present in ambient PM10 samples: A four year investigation from Delhi region, India

NASA Astrophysics Data System (ADS)

Yadav, Shweta; Tandon, Ankit; Attri, Arun K.

2014-12-01

The detection of nicotine, an organic tracer for Environmental Tobacco Smoke (ETS), in the collected PM10 samples from Delhi region's ambient environment, in a appropriately designed investigation was initiated over four years (2006-2009) to: (1) Comprehend seasonal and inter-annual variations in the nicotine present in PM10; (2) Extract regression based linear trend profile manifested by nicotine in PM10; (3) Determine the non-linear trend timeline from the nicotine data, and compare it with the obtained linear trend; (4) Suggest the possible use of the designed experiment and analysis to have a qualitative appraisal of Tobacco Smoking activity in the sampling region. The PM10 samples were collected in a monthly time-series sequence at a known receptor site. Quantitative estimates of nicotine (ng m-3) were made by using a Thermal Desorption Gas Chromatography Mass Spectrometry (TD-GC/MS). The annual average concentrations of nicotine (ng m-3) were 516 ± 302 (2008) > 494 ± 301 (2009) > 438 ± 250 (2007) > 325 ± 149 (2006). The estimated linear trend of 5.4 ng m-3 month-1 corresponded to 16.3% per annum increase in the PM10 associated nicotine. The industrial production of India's tobacco index normalized to Delhi region's consumption, pegged an increase at 10.5% per annum over this period.

43 CFR 3425.1-5 - Leasing outside coal production regions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Leasing outside coal production regions... Leasing on Application § 3425.1-5 Leasing outside coal production regions. A lease sale may be held in response to an application under this subpart if the application covers coal deposits which are outside...

43 CFR 3425.1-5 - Leasing outside coal production regions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Leasing outside coal production regions... Leasing on Application § 3425.1-5 Leasing outside coal production regions. A lease sale may be held in response to an application under this subpart if the application covers coal deposits which are outside...

43 CFR 3425.1-5 - Leasing outside coal production regions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Leasing outside coal production regions... Leasing on Application § 3425.1-5 Leasing outside coal production regions. A lease sale may be held in response to an application under this subpart if the application covers coal deposits which are outside...

43 CFR 3425.1-5 - Leasing outside coal production regions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Leasing outside coal production regions... Leasing on Application § 3425.1-5 Leasing outside coal production regions. A lease sale may be held in response to an application under this subpart if the application covers coal deposits which are outside...

Analysing regional climate change in Africa in a 1.5 °C global warming world

NASA Astrophysics Data System (ADS)

Weber, Torsten; Haensler, Andreas; Jacob, Daniela

2017-04-01

At the 21st session of the UNFCCC Conference of the Parties (COP21) in Paris, a reaffirmation to strengthen the effort to limit the global temperature increase to 1.5 °C was decided. However, even if global warming is limited, some regions might still be substantially affected by climate change, especially for continents like Africa where the socio-economic conditions are strongly linked to the climatic conditions. Hence, providing a detailed analysis of the projected climate changes in a 1.5 °C global warming scenario will allow the African society to undertake measures for adaptation in order to mitigate potential negative consequences. In order to provide such climate change information, the existing CORDEX Africa ensemble for RCP2.6 scenario simulations has systematically been increased by conducting additional REMO simulations using data from various global circulation models (GCMs) as lateral boundary conditions. Based on this ensemble, which now consists of eleven CORDEX Africa RCP2.6 regional climate model simulations from three RCMs (forced with different GCMs), various temperature and precipitation indices such as number of cold/hot days and nights, duration of the rainy season, the amount of rainfall in the rainy seasons and the number of dry spells have been calculated for a 1.5 °C global warming scenario. The applied method to define the 1.5 °C global warming period has been already applied in the IMPACT2C project. In our presentation, we will discuss the analysis of the climate indices in a 1.5 °C global warming world for the CORDEX-Africa region. Amongst presenting the magnitude of projected changes, we will also address the question for selected indices if the changes projected in a 1.5 °C global warming scenario are already larger than the climate variability and we will also draw links to the changes projected under a more extreme scenario.

A Novel Class of Pseudoautosomal Region 1 Deletions Downstream of SHOX Is Associated with Léri-Weill Dyschondrosteosis

PubMed Central

Benito-Sanz, Sara; Thomas, N. Simon; Huber, Céline; del Blanco, Darya Gorbenko; Aza-Carmona, Miriam; Crolla, John A.; Maloney, Vivienne; Argente, Jesús; Campos-Barros, Ángel; Cormier-Daire, Valérie; Heath, Karen E.

2005-01-01

Léri-Weill dyschondrosteosis (LWD) is a pseudoautosomal dominant disorder characterized by disproportionate short stature and a characteristic curving of the radius, known as the “Madelung deformity.” SHOX mutations resulting in SHOX haploinsufficiency have been found in LWD and in a variable proportion of patients with idiopathic short stature (ISS), whereas homozygous loss of SHOX results in the more severe Langer mesomelic dysplasia (LMD). Defects in SHOX have been identified in ∼60% of LWD cases, whereas, in the remaining ∼40%, the molecular basis is unknown. This suggests either genetic heterogeneity or the presence of mutations in unanalyzed regions of SHOX, such as the upstream, intragenic, or downstream regulatory sequences. Therefore, the pseudoautosomal region 1 (PAR1) of 80 patients with LWD, in whom SHOX deletions and mutations had been excluded, was screened for deletions by use of a new panel of microsatellite markers. We identified 12 patients with LWD who presented with a novel class of PAR1 deletions that did not include SHOX. The deletions were of variable size and mapped at least ∼30–530 kb downstream of SHOX. In our cohort, this type of deletion accounted for 15% of cases. In all cases, the deletions cosegregated with the phenotype. No apparent phenotypic differences were observed between patients with SHOX deletions and those with this new class of PAR1 deletions. Thus, we present here the identification of a second PAR1 region implicated in the etiopathogenesis of LWD. Our findings suggest the presence of distal regulatory elements of SHOX transcription in PAR1 or, alternatively, the existence of an additional locus apparently involved in the control of skeletal development. Deletion analysis of this newly identified region should be included in the mutation screening of patients with LWD, LMD, and ISS. PMID:16175500

EPA Region 1 - Valley Depth in Meters

EPA Pesticide Factsheets

Raster of the Depth in meters of EPA-delimited Valleys in Region 1.Valleys (areas that are lower than their neighbors) were extracted from a Digital Elevation Model (USGS, 30m) by finding the local average elevation, subtracting the actual elevation from the average, and selecting areas where the actual elevation was below the average. The landscape was sampled at seven scales (circles of 1, 2, 4, 7, 11, 16, and 22 km radius) to take into account the diversity of valley shapes and sizes. Areas selected in at least four scales were designated as valleys.

The hidden dynamics of relativistic electrons (0.7-1.5 MeV) in the inner zone and slot region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Claudepierre, Seth G.; O'Brien, T. P.; Fennell, J. F.

We present measurements of relativistic electrons (0.7–1.5 MeV) in the inner zone and slot region obtained by the Magnetic Electron and Ion Spectrometer (MagEIS) instrument on Van Allen Probes. The data presented are corrected for background contamination, which is primarily due to inner-belt protons in these low-L regions. We find that ~1 MeV electrons were transported into the inner zone following the two largest geomagnetic storms of the Van Allen Probes era to date, the March and June 2015 events. As ~1 MeV electrons were not observed in Van Allen Probes data in the inner zone prior to these twomore » events, the injections created a new inner belt that persisted for at least 1.5 years. In contrast, we find that electrons injected into the slot region decay on much faster timescales, approximately tens of days. Furthermore, we find no evidence of >1.5 MeV electrons in the inner zone during the entire time interval considered (April 2013 through September 2016). The energies we examine thus span a transition range in the steeply falling inner zone electron spectrum, where modest intensities are observed at 0.7 MeV, and no electrons are observed at 1.5 MeV. To validate the results obtained from the background corrected flux measurements, we also present detailed pulse-height spectra from individual MagEIS detectors. These measurements confirm our results and also reveal low-intensity inner zone and slot region electrons that are not captured in the standard background corrected data product. Lastly, we briefly discuss efforts to refine the upper limit of inner zone MeV electron flux obtained in earlier work.« less

The hidden dynamics of relativistic electrons (0.7-1.5 MeV) in the inner zone and slot region

DOE PAGES

Claudepierre, Seth G.; O'Brien, T. P.; Fennell, J. F.; ...

2017-03-15

We present measurements of relativistic electrons (0.7–1.5 MeV) in the inner zone and slot region obtained by the Magnetic Electron and Ion Spectrometer (MagEIS) instrument on Van Allen Probes. The data presented are corrected for background contamination, which is primarily due to inner-belt protons in these low-L regions. We find that ~1 MeV electrons were transported into the inner zone following the two largest geomagnetic storms of the Van Allen Probes era to date, the March and June 2015 events. As ~1 MeV electrons were not observed in Van Allen Probes data in the inner zone prior to these twomore » events, the injections created a new inner belt that persisted for at least 1.5 years. In contrast, we find that electrons injected into the slot region decay on much faster timescales, approximately tens of days. Furthermore, we find no evidence of >1.5 MeV electrons in the inner zone during the entire time interval considered (April 2013 through September 2016). The energies we examine thus span a transition range in the steeply falling inner zone electron spectrum, where modest intensities are observed at 0.7 MeV, and no electrons are observed at 1.5 MeV. To validate the results obtained from the background corrected flux measurements, we also present detailed pulse-height spectra from individual MagEIS detectors. These measurements confirm our results and also reveal low-intensity inner zone and slot region electrons that are not captured in the standard background corrected data product. Lastly, we briefly discuss efforts to refine the upper limit of inner zone MeV electron flux obtained in earlier work.« less

Groundwater management in Cusco region, Peru Present and future challenges

NASA Astrophysics Data System (ADS)

Guttman, Joseph; Berger, Diego; Pumayalli Saloma, Rene

2013-04-01

The agriculture in the rural areas in the Andes Mountains at Cusco region-Peru is mainly rain fed agriculture and basically concentrated to one crop season per year. This situation limits the farmer's development. In order to increase the agricultural season into the winter period (May to November) also known as the dry season, many farmers are pumping water from streams or underground water that unfortunately leads to many of them becoming dry during the winter/dry season. In addition, some of those streams are polluted by the city's wastewater and heavy metals that are released from mines which are quite abundant in the Andes Mountains. The regional government through its engineering organization "Per Plan Meriss Inka", is trying to increase the water quantity and quality to the end users (farmers in the valleys) by promoting projects that among others include capturing of springs that emerge from the high mountain ridges, diverting streams and harvesting surface reservoirs. In the Ancahuasi area (Northwest of Cusco) are many springs that emerge along several geological faults that act as a border line between the permeable layers (mostly sandstone) in the upper throw of the fault and impermeable layers in the lower throw of the fault. The discharge of the springs varies in dependence to the size of each catchment area or aquifer structure. The spring water is collected in small pools and then by gravity through open channels to the farmers in the valleys. During the past 25 years, in some places, springs have been captured by horizontal wells (gallery) that were excavated from the fault zone into the mountain a few tens of meters below the spring outlet. The gallery drains excess water from the spring storage and increases the overall discharge. The galleries are a limited solution to individual places where the geology, hydrology and the topography enable it. The farmers are using flood irrigation systems which according to World Bank documents, the overall

Present-Day Kinematics of the Central Mediterranean Plate Boundary Region from Large GPS Network Analysis Using the Ambizap Algorithm

NASA Astrophysics Data System (ADS)

D'Anastasio, E.; D'Agostino, N.; Avallone, A.; Blewitt, G.

2008-12-01

The large, recent increase of continuous GPS (CGPS) stations in the Central Mediterranean plate boundary zone offers the opportunity to study in detail the present-day kinematics of this actively deforming region. CGPS data from scientific and commercial networks in the Italian region is now available from more than 350 stations, including more than 130 from the RING network deployed by the Istituto Nazionale di Geofisica e Vulcanologia. The RING stations all have high quality GPS monuments and are co- located with broadband or very broadband seismometers and strong motion sensors. The analysis presented here also uses far-field data to provide reference frame control, bringing the total to over 580 CGPS stations. GPS ambiguity resolution of such a large amount of data presents a serious challenge in terms of processing time. Many scientific GPS data processing software packages address this problem by dividing the network into several clusters. In contrast, this analysis uses the new Ambizap GPS processing algorithm (Blewitt, 2008) to obtain unique, self-consistent daily ambiguity-fixed solutions for the entire network. Ambizap allows for a rapid and multiple reanalysis of large regional networks such the one presented in this work. Tests show that Ambizap reproduces solutions from time-prohibitive full-network ambiguity resolution to much less than 1 mm. Single station GPS data are first processed with the GIPSY-OASIS II software by the precise point positioning (PPP) strategy (Zumberge et al., 1997) using JPL products from ftp://sideshow.jpl.nasa.gov. Integer ambiguity resolution is then applied using Ambizap. The resulting daily solutions are aligned to the ITRF2005 reference frame. Then, using the CATS software (Williams, 2007), time series are cleaned to remove outliers and are analyzed for their noise properties, linear velocities, periodic signals and antenna jumps. Stable plate reference frames are realized by minimizing the horizontal velocities at more

New PAH gene promoter KLF1 and 3'-region C/EBPalpha motifs influence transcription in vitro.

PubMed

Klaassen, Kristel; Stankovic, Biljana; Kotur, Nikola; Djordjevic, Maja; Zukic, Branka; Nikcevic, Gordana; Ugrin, Milena; Spasovski, Vesna; Srzentic, Sanja; Pavlovic, Sonja; Stojiljkovic, Maja

2017-02-01

Phenylketonuria (PKU) is a metabolic disease caused by mutations in the phenylalanine hydroxylase (PAH) gene. Although the PAH genotype remains the main determinant of PKU phenotype severity, genotype-phenotype inconsistencies have been reported. In this study, we focused on unanalysed sequences in non-coding PAH gene regions to assess their possible influence on the PKU phenotype. We transiently transfected HepG2 cells with various chloramphenicol acetyl transferase (CAT) reporter constructs which included PAH gene non-coding regions. Selected non-coding regions were indicated by in silico prediction to contain transcription factor binding sites. Furthermore, electrophoretic mobility shift assay (EMSA) and supershift assays were performed to identify which transcriptional factors were engaged in the interaction. We found novel KLF1 motif in the PAH promoter, which decreases CAT activity by 50 % in comparison to basal transcription in vitro. The cytosine at the c.-170 promoter position creates an additional binding site for the protein complex involving KLF1 transcription factor. Moreover, we assessed for the first time the role of a multivariant variable number tandem repeat (VNTR) region located in the 3'-region of the PAH gene. We found that the VNTR3, VNTR7 and VNTR8 constructs had approximately 60 % of CAT activity. The regulation is mediated by the C/EBPalpha transcription factor, present in protein complex binding to VNTR3. Our study highlighted two novel promoter KLF1 and 3'-region C/EBPalpha motifs in the PAH gene which decrease transcription in vitro and, thus, could be considered as PAH expression modifiers. New transcription motifs in non-coding regions will contribute to better understanding of the PKU phenotype complexity and may become important for the optimisation of PKU treatment.

Genetic analysis of tachyzoite to bradyzoite differentiation mutants in Toxoplasma gondii reveals a hierarchy of gene induction.

PubMed

Singh, Upinder; Brewer, Jeremy L; Boothroyd, John C

2002-05-01

Developmental switching in Toxoplasma gondii, from the virulent tachyzoite to the relatively quiescent bradyzoite stage, is responsible for disease propagation and reactivation. We have generated tachyzoite to bradyzoite differentiation (Tbd-) mutants in T. gondii and used these in combination with a cDNA microarray to identify developmental pathways in bradyzoite formation. Four independently generated Tbd- mutants were analysed and had defects in bradyzoite development in response to multiple bradyzoite-inducing conditions, a stable phenotype after in vivo passages and a markedly reduced brain cyst burden in a murine model of chronic infection. Transcriptional profiles of mutant and wild-type parasites, growing under bradyzoite conditions, revealed a hierarchy of developmentally regulated genes, including many bradyzoite-induced genes whose transcripts were reduced in all mutants. A set of non-developmentally regulated genes whose transcripts were less abundant in Tbd- mutants were also identified. These may represent genes that mediate downstream effects and/or whose expression is dependent on the same transcription factors as the bradyzoite-induced set. Using these data, we have generated a model of transcription regulation during bradyzoite development in T. gondii. Our approach shows the utility of this system as a model to study developmental biology in single-celled eukaryotes including protozoa and fungi.

Octree Bin-to-Bin Fractional-NTC Collisions

DTIC Science & Technology

2015-09-17

Briefing Charts 3. DATES COVERED (From - To) 24 August 2015 – 17 September 2015 4. TITLE AND SUBTITLE Octree bin-to-bin fractional -NTC collisions...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. 239.18 OCTREE BIN-TO-BIN FRACTIONAL -NTC COLLISIONS Robert Martin ERC INC., SPACECRAFT PROPULSION...AFTC/PA clearance No. TBD ROBERT MARTIN (AFRL/RQRS) DISTRIBUTION A: APPROVED FOR PUBLIC RELEASE 1 / 15 OUTLINE 1 BACKGROUND 2 FRACTIONAL COLLISIONS 3 BIN

Novel cross-linked polystyrenes with large space network as tailor-made catalyst supports for sustainable media

DOE PAGES

Marrocchi, Assunta; Adriaensens, Peter; Bartollini, Elena; ...

2015-10-09

For a novel class of polystyrene-based gel-type resins (SPACeR, SP), containing the large 1,4-bis (4-vinylphenoxy)benzene cross-linker, is introduced; SP-immobilized 1,5,7-triazabicyclo [4.4.0]dec-5-ene (TBD) and triethylamine (TEA) bases are synthesized and characterized in terms of their structural, thermal and morphological features, and their catalytic efficiency in a series of fundamental chemical transformations under solvent-free conditions is investigated.

The D1-D2 region of the large subunit ribosomal DNA as barcode for ciliates.

PubMed

Stoeck, T; Przybos, E; Dunthorn, M

2014-05-01

Ciliates are a major evolutionary lineage within the alveolates, which are distributed in nearly all habitats on our planet and are an essential component for ecosystem function, processes and stability. Accurate identification of these unicellular eukaryotes through, for example, microscopy or mating type reactions is reserved to few specialists. To satisfy the demand for a DNA barcode for ciliates, which meets the standard criteria for DNA barcodes defined by the Consortium for the Barcode of Life (CBOL), we here evaluated the D1-D2 region of the ribosomal DNA large subunit (LSU-rDNA). Primer universality for the phylum Ciliophora was tested in silico with available database sequences as well as in the laboratory with 73 ciliate species, which represented nine of 12 ciliate classes. Primers tested in this study were successful for all tested classes. To test the ability of the D1-D2 region to resolve conspecific and congeneric sequence divergence, 63 Paramecium strains were sampled from 24 mating species. The average conspecific D1-D2 variation was 0.18%, whereas congeneric sequence divergence averaged 4.83%. In pairwise genetic distance analyses, we identified a D1-D2 sequence divergence of <0.6% as an ideal threshold to discriminate Paramecium species. Using this definition, only 3.8% of all conspecific and 3.9% of all congeneric sequence comparisons had the potential of false assignments. Neighbour-joining analyses inferred monophyly for all taxa but for two Paramecium octaurelia strains. Here, we present a protocol for easy DNA amplification of single cells and voucher deposition. In conclusion, the presented data pinpoint the D1-D2 region as an excellent candidate for an official CBOL barcode for ciliated protists. © 2013 John Wiley & Sons Ltd.

Downwash in Vortex Region Behind Rectangular Half-wing at Mach Number 1.91

NASA Technical Reports Server (NTRS)

Cummings, John L; Haefeli, Rudolph C

1950-01-01

Results of an experimental investigation to determine downwash and wake characteristics in region of trailing vortex system behind a rectangular half-wing at Mach number 1.91 are presented. The wing had a 5-percent thick symmetric diamond cross section beveled to a knife edge at the tip. At small angles of attack, downwash angles were in close agreement with predictions of linearized theory based on the assumption of an undistorted vortex sheet. At higher angles of attack, the flow was greatly influenced by the rolling up of the vortex sheet.

78 FR 53132 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

...: Title, Associated Form and OMB Number: National Geospatial-Intelligence Agency Enterprise Workforce System; OMB Control Number 0704-TBD. Type of Request: New Collection. Number of Respondents: 12,000...

Regional differences in clinical care among patients with type 1 diabetes in Brazil: Brazilian Type 1 Diabetes Study Group

PubMed Central

2012-01-01

Background To determine the characteristics of clinical care offered to type 1 diabetic patients across the four distinct regions of Brazil, with geographic and contrasting socioeconomic differences. Glycemic control, prevalence of cardiovascular risk factors, screening for chronic complications and the frequency that the recommended treatment goals were met using the American Diabetes Association guidelines were evaluated. Methods This was a cross-sectional, multicenter study conducted from December 2008 to December 2010 in 28 secondary and tertiary care public clinics in 20 Brazilian cities in north/northeast, mid-west, southeast and south regions. The data were obtained from 3,591 patients (56.0% females and 57.1% Caucasians) aged 21.2 ± 11.7 years with a disease duration of 9.6 ± 8.1 years (<1 to 50 years). Results Overall, 18.4% patients had HbA1c levels <7.0%, and 47.5% patients had HbA1c levels ≥ 9%. HbA1c levels were associated with lower economic status, female gender, age and the daily frequency of self-blood glucose monitoring (SBGM) but not with insulin regimen and geographic region. Hypertension was more frequent in the mid-west (32%) and north/northeast (25%) than in the southeast (19%) and south (17%) regions (p<0.001). More patients from the southeast region achieved LDL cholesterol goals and were treated with statins (p<0.001). Fewer patients from the north/northeast and mid-west regions were screened for retinopathy and nephropathy, compared with patients from the south and southeast. Patients from the south/southeast regions had more intensive insulin regimens than patients from the north/northeast and mid-west regions (p<0.001). The most common insulin therapy combination was intermediate-acting with regular human insulin, mainly in the north/northeast region (p<0.001). The combination of insulin glargine with lispro and glulisine was more frequently used in the mid-west region (p<0.001). Patients from the north/northeast region were younger

Geologic Map of the Snegurochka Planitia Quadrangle (V-1): Implications for the Volcanic History of the North Polar Region of Venus

NASA Technical Reports Server (NTRS)

Hurwitz, D. M.; Head, J. W.

2010-01-01

Geologic mapping of Snegurochka Planitia (V-1) reveals a complex stratigraphy of tectonic and volcanic features that can provide insight into the geologic history of Venus and Archean Earth [1,2], including 1) episodes of both localized crustal uplift and mantle downwelling, 2) shifts from local to regional volcanic activity, and 3) a shift back to local volcanic activity. We present our interpretations of the volcanic history of the region surrounding the north pole of Venus and explore how analysis of new data support our interpretations

Sequence diversity of the C-terminal region of Plasmodium falciparum merozoite surface protein 1 in southern Iran.

PubMed

Zamani, Zahra; Razavi, Mohammad Reza; Sadeghi, Sedigheh; Naddaf, Saeed; Pourfallah, Fatemeh; Mirkhani, Fatemeh; Arjmand, Mohammad; Feizhaddad, Hossein; Rad, Mina Ebrahimi; Ebrahimi Rad, Mina; Tameemi, Marzieh; Assmar, Mehdi

2009-01-01

The C-terminal region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum is a strong vaccine candidate as it is associated with immunity to the parasite. This corresponds approximately to the conserved 17th block of the gene and is composed of two EGF- like domains. These domains exhibit only four single amino acid substitutions which show several potential variants in this region of the gene. As the variations might be important for a regional vaccine design, a study was carried out to determine the variations present in P. falciparum isolates from southern Iran. Besides the usual E-T-S-R-L and the Q-K-N-G-F types, we found Q-T-S-R-L, E-K-N-G-F, E-T-S-G-L, Z-T-S-G-L and Z-T-S-R-L types, where Z was E or Q signifying the presence of mixed clones in single isolates.

Non-codified traditional medicine practices from Belgaum Region in Southern India: present scenario

PubMed Central

2014-01-01

Background Traditional medicine in India can be classified into codified (Ayurveda, Unani, Siddha, Homeopathy) and non-codified (folk medicine) systems. Both the systems contributing equally to the primary healthcare in India. The present study is aimed to understand the current scenario of medicinal practices of non-codified system of traditional medicine in Belgaum region, India. Methods The study has been conducted as a basic survey of identified non-codified traditional practitioners by convenience sampling with semi structured, open ended interviews and discussions. The learning process, disease diagnosis, treatment, remuneration, sharing of knowledge and socio-demographic data was collected, analysed and discussed. Results One hundred and forty traditional practitioners were identified and interviewed for the present study. These practitioners are locally known as “Vaidya”. The study revealed that the non-codified healthcare tradition is practiced mainly by elderly persons in the age group of 61 years and above (40%). 73% of the practitioners learnt the tradition from their forefathers, and 19% of practitioners developed their own practices through experimentation, reading and learning. 20% of the practitioners follow distinctive “Nadi Pariksha” (pulse examination) for disease diagnosis, while others follow bodily symptoms and complaints. 29% of the traditional practitioners do not charge anything, while 59% practitioners receive money as remuneration. Plant and animal materials are used as sources of medicines, with a variety of preparation methods. The preference ranking test revealed higher education and migration from villages are the main reasons for decreasing interest amongst the younger generation, while deforestation emerged as the main cause of medicinal plants depletion. Conclusion Patrilineal transfer of the knowledge to younger generation was observed in Belgaum region. The observed resemblance in disease diagnosis, plant collection and

PLANNING MODELS FOR URBAN WATER SUPPLY EXPANSION. VOLUME 1. PLANNING FOR THE EXPANSION OF REGIONAL WATER SUPPLY SYSTEMS

EPA Science Inventory

A three-volume report was developed relative to the modelling of investment strategies for regional water supply planning. Volume 1 is the study of capacity expansion over time. Models to aid decision making for the deterministic case are presented, and a planning process under u...

Impacts of Present and Future Climate Variability on Forest Ecosystem in Mediterranean Region

NASA Astrophysics Data System (ADS)

Ozcan, O.; Musaoglu, N.; Türkeş, M.

2017-12-01

The concept of `climate change vulnerability' helps us to better comprehend the cause/effect relationships behind climate change and its impact on human societies, socioeconomic sectors, physiographical and ecological systems. Herein, multifactorial spatial modeling was applied to evaluate the vulnerability of a Mediterranean forest ecosystem to climate change. Thus, the geographical distribution of the final Environmental Vulnerability Areas (EVAs) of the forest ecosystem are based on the estimated final Environmental Vulnerability Index (EVI) values. This revealed that at current levels of environmental degradation, physical, geographical, policy enforcement and socioeconomic conditions, the area with a "very low" vulnerability degree covered mainly the town, its surrounding settlements and the agricultural lands found mainly over the low and flat travertine plateau and the plains at the east and southeast of the district. The spatial magnitude of the EVAs over the forest ecosystem under the current environmental degradation was also determined. This revealed that the EVAs classed as "very low" account for 21% of the total area of the forest ecosystem, those classed as "low" account for 36%, those classed as "medium" account for 20%, and those classed as "high" account for 24%. Based on regionally averaged future climate assessments and projected future climate indicators, both the study site and the western Mediterranean sub-region of Turkey will probably become associated with a drier, hotter, more continental and more water-deficient climate. This analysis holds true for all future scenarios, with the exception of RCP4.5 for the period from 2015 to 2030. However, the present dry-sub humid climate dominating this sub-region and the study area shows a potential for change towards more dry climatology and for it to become a semiarid climate in the period between 2031 and 2050 according to the RCP8.5 high emission scenario. All the observed and estimated results

77 FR 43812 - Information Collection; Submission for OMB Review, Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... (ICR) entitled National Evaluation of the Social Innovation Fund for review and approval in accordance... Community Service. Title: National Evaluation of the Social Innovation Fund. OMB Number: TBD. Agency Number...

OXA-Carbapenemases Present in Clinical Acinetobacter baumannii-calcoaceticus Complex Isolates from Patients in Kurdistan Region, Iraq.

PubMed

Ganjo, Aryann R; Maghdid, Delshad M; Mansoor, Isam Y; Kok, Dik J; Severin, Juliette A; Verbrugh, Henri A; Kreft, Deborah; Fatah, M H; Alnakshabandi, A A; Dlnya, Asad; Hammerum, Anette M; Ng, Kim; Goessens, Wil

2016-12-01

In addition to intrinsic resistance in Acinetobacter baumannii, many different types of acquired resistance mechanisms have been reported, including the presence of VIM and IMP metallo β-lactamases and also of bla OXA-23-like and bla OXA-58-like enzymes. In the Kurdistan region of Iraq, the multiresistant A. baumannii-calcoaceticus complex is prevalent. We characterized the different mechanisms of resistance present in clinical isolates collected from different wards and different hospitals from the Kurdistan region. One hundred twenty clinical nonduplicate A. baumannii-calcoaceticus complex isolates were collected from four hospitals between January 2012 and October 2013. The identification of the isolates was confirmed by MALDI-TOF. The susceptibility to different antibiotics was determined by disk diffusion and analyzed in accordance to EUCAST guidelines. By PCR, the presence of bla OXA-51-like , bla OXA-23-like , bla OXA-24-like , and bla OXA-58-like genes was determined as well as the presence of the insertion element ISAba1. Clonal diversity was analyzed by pulsed-field gel electrophoresis (PFGE) using the restriction enzyme ApaI and, in addition, multilocus sequence typing (MLST) was performed on a selected subset of 15 isolates. All 120 A. baumannii isolates harbored bla OXA-51-like genes. One hundred one out of 110 (92%) imipenem (IMP)-resistant A. baumannii-calcoaceticus complex isolates additionally carried the bla OXA-23-like gene and four isolates (3%) were positive for bla OXA-24-like. All 101 bla OXA-23-like -positive isolates had the ISAba1 insertion sequence, 1,600 bp upstream of the bla OXA-23-like gene. The bla OXA-58-like gene was not detected in any of the 110 IMP-resistant strains. Eight different PFGE clusters were identified and distributed over the different hospitals. MLST analysis performed on a subset of 15 representative isolates revealed the presence of the international clone ST2 (Pasteur). Besides ST2 (Pasteur), also many other

Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Liwei; Zhao, Wenting; Zheng, Quanhui

2016-01-15

The expression change of cellular senescence-associated genes is underlying the genetic foundation of cellular senescence. Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) as a novel senescence-associated gene. CSIG is implicated in various process including cell cycle regulation, apoptosis, and tumor metastasis. We previously showed that CSIG plays an important role in regulating cell proliferation and cellular senescence progression through inhibiting PTEN, however, which domain or region of CSIG contributes to this function? To clarify this question, we investigated the functional importance of ribosomal L1 domain and lysine (Lys) -rich region of CSIG. Themore » data showed that expression of CSIG potently reduced PTEN expression, increased cell proliferation rates, and reduced the senescent phenotype (lower SA-β-gal activity). By contrast, neither the expression of CSIG N- terminal (NT) fragment containing the ribosomal L1 domain nor C-terminal (CT) fragment containing Lys-rich region could significantly altered the levels of PTEN; instead of promoting cell proliferation and delaying cellular senescence, expression of CSIG-NT or CSIG-CT inhibited cell proliferation and accelerated cell senescence (increased SA-β-gal activity) compared to either CSIG over-expressing or control (empty vector transfected) cells. The further immunofluorescence analysis showed that CSIG-CT and CSIG-NT truncated proteins exhibited different subcellular distribution with that of wild-type CSIG. Conclusively, both ribosomal L1 domain and Lys-rich region of CSIG are critical for CSIG to act as a regulator of cell proliferation and cellular senescence. - Highlights: • The ribosomal L1 domain and lysine-rich region of CSIG were expressed. • They are critical for CSIG to regulate proliferation and senescence. • CSIG and its domains exhibit different subcellular distribution.« less

Evolution of a behavior-linked microsatellite-containing element in the 5' flanking region of the primate AVPR1A gene

PubMed Central

2008-01-01

Background The arginine vasopressin V1a receptor (V1aR) modulates social cognition and behavior in a wide variety of species. Variation in a repetitive microsatellite element in the 5' flanking region of the V1aR gene (AVPR1A) in rodents has been associated with variation in brain V1aR expression and in social behavior. In humans, the 5' flanking region of AVPR1A contains a tandem duplication of two ~350 bp, microsatellite-containing elements located approximately 3.5 kb upstream of the transcription start site. The first block, referred to as DupA, contains a polymorphic (GT)25 microsatellite; the second block, DupB, has a complex (CT)4-(TT)-(CT)8-(GT)24 polymorphic motif, known as RS3. Polymorphisms in RS3 have been associated with variation in sociobehavioral traits in humans, including autism spectrum disorders. Thus, evolution of these regions may have contributed to variation in social behavior in primates. We examined the structure of these regions in six ape, six monkey, and one prosimian species. Results Both tandem repeat blocks are present upstream of the AVPR1A coding region in five of the ape species we investigated, while monkeys have only one copy of this region. As in humans, the microsatellites within DupA and DupB are polymorphic in many primate species. Furthermore, both single (lacking DupB) and duplicated alleles (containing both DupA and DupB) are present in chimpanzee (Pan troglodytes) populations with allele frequencies of 0.795 and 0.205 for the single and duplicated alleles, respectively, based on the analysis of 47 wild-caught individuals. Finally, a phylogenetic reconstruction suggests two alternate evolutionary histories for this locus. Conclusion There is no obvious relationship between the presence of the RS3 duplication and social organization in primates. However, polymorphisms identified in some species may be useful in future genetic association studies. In particular, the presence of both single and duplicated alleles in

Evolution of a behavior-linked microsatellite-containing element in the 5' flanking region of the primate AVPR1A gene.

PubMed

Donaldson, Zoe R; Kondrashov, Fyodor A; Putnam, Andrea; Bai, Yaohui; Stoinski, Tara L; Hammock, Elizabeth A D; Young, Larry J

2008-06-23

The arginine vasopressin V1a receptor (V1aR) modulates social cognition and behavior in a wide variety of species. Variation in a repetitive microsatellite element in the 5' flanking region of the V1aR gene (AVPR1A) in rodents has been associated with variation in brain V1aR expression and in social behavior. In humans, the 5' flanking region of AVPR1A contains a tandem duplication of two approximately 350 bp, microsatellite-containing elements located approximately 3.5 kb upstream of the transcription start site. The first block, referred to as DupA, contains a polymorphic (GT)25 microsatellite; the second block, DupB, has a complex (CT)4-(TT)-(CT)8-(GT)24 polymorphic motif, known as RS3. Polymorphisms in RS3 have been associated with variation in sociobehavioral traits in humans, including autism spectrum disorders. Thus, evolution of these regions may have contributed to variation in social behavior in primates. We examined the structure of these regions in six ape, six monkey, and one prosimian species. Both tandem repeat blocks are present upstream of the AVPR1A coding region in five of the ape species we investigated, while monkeys have only one copy of this region. As in humans, the microsatellites within DupA and DupB are polymorphic in many primate species. Furthermore, both single (lacking DupB) and duplicated alleles (containing both DupA and DupB) are present in chimpanzee (Pan troglodytes) populations with allele frequencies of 0.795 and 0.205 for the single and duplicated alleles, respectively, based on the analysis of 47 wild-caught individuals. Finally, a phylogenetic reconstruction suggests two alternate evolutionary histories for this locus. There is no obvious relationship between the presence of the RS3 duplication and social organization in primates. However, polymorphisms identified in some species may be useful in future genetic association studies. In particular, the presence of both single and duplicated alleles in chimpanzees provides a

Elemental identification of blue paintings traces present in historic cemeteries in the São Martinho region, southern Brazil

NASA Astrophysics Data System (ADS)

Costa, Thiago G.; Richter, Fábio Andreas; Castro, Elisiana Trilha; Gonçalves, Samantha; Spudeit, Daniel A.; Micke, Gustavo A.

2018-03-01

Cemeteries are of great significance in many communities, often being considered of invaluable historical, artistic, architectural and cultural significance and thus they need to be preserved. In this regard, understanding the historical aspects and the construction techniques used is essential for their protection. The purpose of this paper is to describe historical aspects of the funerary heritage present in the region of São Martinho in southern Brazil, along with an analysis of the blue paint found in cemeteries of German colonies in the region studied. FTIR analysis suggests that the binder is composed mostly of a protein resin and a small amount of lipid. The morphology of the pigment was investigated by SEM and EDS and the spectra revealed that the major elements present in the blue pigment are Na, Al, Si and S, with an overlap in the elemental mapping, indicative of ultramarine pigments. The GC-MS results are consistent with the type of binder identified by FTIR and indicate a mixture of oils, probably from vegetal sources, and proteins.

40 CFR 1.61 - Regional Offices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL... comprehensive and integrated environmental protection activities; (c) Total resource management in their Regions within guidelines provided by Headquarters; (d) Conducting effective Regional enforcement and compliance...

40 CFR 1.61 - Regional Offices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL... comprehensive and integrated environmental protection activities; (c) Total resource management in their Regions within guidelines provided by Headquarters; (d) Conducting effective Regional enforcement and compliance...

Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

PubMed Central

2004-01-01

IL-1F7b, a novel homologue of the IL-1 (interleukin 1) family, was discovered by computational cloning. We demonstrated that IL-1F7b shares critical amino acid residues with IL-18 and binds to the IL-18-binding protein enhancing its ability to inhibit IL-18-induced interferon-γ. We also showed that low levels of IL-1F7b are constitutively present intracellularly in human blood monocytes. In this study, we demonstrate that similar to IL-18, both mRNA and intracellular protein expression of IL-1F7b are up-regulated by LPS (lipopolysaccharide) in human monocytes. In stable transfectants of murine RAW264.7 macrophage cells, there was no IL-1F7b protein expression despite a highly active CMV promoter. We found that IL-1F7b-specific mRNA was rapidly degraded in transfected cells, via a 3′-UTR (untranslated region)-independent control of IL-1F7b transcript stability. After LPS stimulation, there was a rapid transient increase in IL-1F7b-specific mRNA and concomitant protein levels. Using sequence alignment, we found a conserved ten-nucleotide homology box within the open reading frame of IL-F7b, which is flanking the coding region instability elements of some selective genes. In-frame deletion of downstream exon 5 from the full-length IL-1F7b cDNA markedly increased the levels of IL-1F7b mRNA. A similar coding region element is located in IL-18. When transfected into RAW264.7 macrophages, IL-18 mRNA was also unstable unless treated with LPS. These results indicate that both IL-1F7b and IL-18 mRNA contain functional instability determinants within their coding region, which influence mRNA decay as a novel mechanism to regulate the expression of IL-1 family members. PMID:15046617

Measurement of regional compliance using 4DCT images for assessment of radiation treatment1

PubMed Central

Zhong, Hualiang; Jin, Jian-yue; Ajlouni, Munther; Movsas, Benjamin; Chetty, Indrin J.

2011-01-01

Purpose: Radiation-induced damage, such as inflammation and fibrosis, can compromise ventilation capability of local functional units (alveoli) of the lung. Ventilation function as measured with ventilation images, however, is often complicated by the underlying mechanical variations. The purpose of this study is to present a 4DCT-based method to measure the regional ventilation capability, namely, regional compliance, for the evaluation of radiation-induced lung damage. Methods: Six 4DCT images were investigated in this study: One previously used in the generation of a POPI model and the other five acquired at Henry Ford Health System. A tetrahedral geometrical model was created and scaled to encompass each of the 4DCT image domains. Image registrations were performed on each of the 4DCT images using a multiresolution Demons algorithm. The images at the end of exhalation were selected as a reference. Images at other exhalation phases were registered to the reference phase. For the POPI-modeled patient, each of these registration instances was validated using 40 landmarks. The displacement vector fields (DVFs) were used first to calculate the volumetric variation of each tetrahedron, which represents the change in the air volume. The calculated results were interpolated to generate 3D ventilation images. With the computed DVF, a finite element method (FEM) framework was developed to compute the stress images of the lung tissue. The regional compliance was then defined as the ratio of the ventilation and stress values and was calculated for each phase. Based on iterative FEM simulations, the potential range of the mechanical parameters for the lung was determined by comparing the model-computed average stress to the clinical reference value of airway pressure. The effect of the parameter variations on the computed stress distributions was estimated using Pearson correlation coefficients. Results: For the POPI-modeled patient, five exhalation phases from the start to

Solar Wind 0.1-1 keV Electrons in the Corotating Interaction Regions

NASA Astrophysics Data System (ADS)

Wang, L.; Tao, J.; Li, G.; Wimmer-Schweingruber, R. F.; Jian, L. K.; He, J.; Tu, C.; Tian, H.; Bale, S. D.

2017-12-01

Here we present a statistical study of the 0.1-1 keV suprathermal electrons in the undisturbed and compressed slow/fast solar wind, for the 71 corotating interaction regions (CIRs) with good measurements from the WIND 3DP and MFI instruments from 1995 to 1997. For each of these CIRs, we separate the strahl and halo electrons based on their different behaviors in pitch angle distributions in the undisturbed and compressed solar wind. We fit both the strahl and halo energy spectra to a kappa function with an index κ index and effective temperature Teff, and calculate the pitch-angle width at half-maximum (PAHM) of the strahl population. We also integrate the electron measurements between 0.1 and 1.0 keV to obtain the number density n and average energy Eavg for the strahl and halo populations. We find that for both the strahl and halo populations within and around these CIRs, the fitted κ index strongly correlates with Teff, similar to the quiet-time solar wind (Tao et al., ApJ, 2016). The number density of both the strahl and halo shows a strong positive correlation with the electron core temperature. The strahl number density ns is correlated with the magnitude of interplanetary magnetic field, and the strahl PAHM width is anti-correlated with the solar wind speed. These results suggest that the origin of strahl electrons from the solar corona is likely related to the electron core temperature and magnetic field strength, while the production of halo electrons in the interplanetary medium could depend on the solar wind velocity.

Regional overview of Latin American and Caribbean energy production, consumption, and future growth. Report series No. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, K.

1994-07-01

The Latin American and Caribbean region - comprising Mexico, Central and South America, and the Caribbean - is relatively well endowed with energy resources, although the distribution of these resources is uneven across countries. The region produces more energy than it consumes, and the surplus energy, which amounts to 3.6 million barrels of oil equivalent per day (boe/d), is mostly oil. While the region`s total oil (crude and products) exports decreased from 4.4 million barrels per day (b/d) in 1981 to 3.8 million b/d in 1992, its net oil exports increased from about 1.6 million b/d in 1981 to 2.8more » million b/d in 1992. In 1993, the surplus oil in Latin America and the Caribbean remained at 2.8 million b/d. This report analyzes the key issues of the Latin American and Caribbean energy industry and presents the future outlook for oil, gas, coal, hydroelectricity, and nuclear power developments in the region. In addition, the status of biomass energy, geothermal, and other noncommercial energy in the region will be briefly discussed in the context of overall energy development. The rest of the report is organized as follows: Section II assesses the current situation of Latin American and Caribbean energy production and consumption, covering primary energy supply, primary energy consumption, downstream petroleum sector development, and natural gas utilization. Section III presents the results of our study of future energy growth in Latin America. Important hydrocarbons policy issues in the region are discussed in Section IV, and a summary and concluding remarks are provided in Section V.« less

13 CFR 304.1 - Designation of Economic Development Districts: Regional eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Designation of Economic Development Districts: Regional eligibility. 304.1 Section 304.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.1 Designation of...

13 CFR 304.1 - Designation of Economic Development Districts: Regional eligibility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Designation of Economic Development Districts: Regional eligibility. 304.1 Section 304.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.1 Designation of...

13 CFR 304.1 - Designation of Economic Development Districts: Regional eligibility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Designation of Economic Development Districts: Regional eligibility. 304.1 Section 304.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.1 Designation of...

13 CFR 304.1 - Designation of Economic Development Districts: Regional eligibility.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Designation of Economic Development Districts: Regional eligibility. 304.1 Section 304.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.1 Designation of...

13 CFR 304.1 - Designation of Economic Development Districts: Regional eligibility.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Designation of Economic Development Districts: Regional eligibility. 304.1 Section 304.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.1 Designation of...

26 CFR 1.430(h)(3)-1 - Mortality tables used to determine present value.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 5 2011-04-01 2011-04-01 false Mortality tables used to determine present value... Mortality tables used to determine present value. (a) Basis for mortality tables—(1) In general. This section sets forth rules for the mortality tables to be used in determining present value or making any...

26 CFR 1.430(h)(3)-1 - Mortality tables used to determine present value.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Mortality tables used to determine present value... Mortality tables used to determine present value. (a) Basis for mortality tables—(1) In general. This section sets forth rules for the mortality tables to be used in determining present value or making any...

26 CFR 1.430(h)(3)-1 - Mortality tables used to determine present value.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Mortality tables used to determine present value... Mortality tables used to determine present value. (a) Basis for mortality tables—(1) In general. This section sets forth rules for the mortality tables to be used in determining present value or making any...

26 CFR 1.430(h)(3)-1 - Mortality tables used to determine present value.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Mortality tables used to determine present value... Mortality tables used to determine present value. (a) Basis for mortality tables—(1) In general. This section sets forth rules for the mortality tables to be used in determining present value or making any...

How to Design and Present Texts to Cultivate Balanced Regional Images in Geography Education

ERIC Educational Resources Information Center

Lee, Dong-Min; Ryu, Jaemyong

2013-01-01

This article examines possibilities associated with the cultivation of balanced regional images via the use of simple methods. Two experiments based on the primacy effect and the painting picture rule, or visual depiction of regions, were conducted. The results show significant differences in the formation of regional images. More specifically,…

Irradiated interfaces in the Ara OB1, Carina, Eagle Nebula, and Cyg OB2 massive star formation regions

DOE PAGES

Hartigan, P.; Palmer, J.; Cleeves, L. I.

2012-09-05

Regions of massive star formation offer some of the best and most easily-observed examples of radiation hydrodynamics. Boundaries where fully-ionized H II regions transition to neutral/molecular photodissociation regions (PDRs) are of particular interest because marked temperature and density contrasts across the boundaries lead to evaporative flows and fluid dynamical instabilities that can evolve into spectacular pillar-like structures. Furthermore, when detached from their parent clouds, pillars become ionized globules that often harbor one or more young stars. H2 molecules at the interface between a PDR and an H II region absorb ultraviolet light from massive stars, and the resulting fluoresced infraredmore » emission lines are an ideal way to trace this boundary independent of obscuring dust. This paper presents H2 images of four regions of massive star formation that illustrate different types of PDR boundaries. The Ara OB1 star formation region contains a striking long wall that has several wavy structures which are present in H2, but the emission is not particularly bright because the ambient UV fluxes are relatively low. In contrast, the Carina star formation region shows strong H2 fluorescence both along curved walls and at the edges of spectacular pillars that in some cases have become detached from their parent clouds. The less-spectacular but more well-known Eagle Nebula has two regions that have strong fluorescence in addition to its pillars. And while somewhat older than the other regions, Cyg OB2 has the highest number of massive stars of the regions surveyed and contains many isolated, fluoresced globules that have head–tail morphologies which point towards the sources of ionizing radiation. Our images provide a collection of potential astrophysical analogs that may relate to ablated interfaces observed in laser experiments of radiation hydrodynamics.« less

Dinuclear (d(3)-d(3)) Diolate Complexes of Molybdenum and Tungsten. 2.(1) Derivatives of 2,2'-Methylenebis(6-tert-butyl-4-methylphenoxide). Direct Observation of the Conversion of Bridged to Chelate Isomers (M = Mo) and Reversible Carbon-Hydrogen Bond Oxidative Addition (M = W).

PubMed

Chisholm, Malcolm H.; Huang, Jui-Hsien; Huffman, John C.; Parkin, Ivan P.

1997-04-09

Hydrocarbon solutions of Mo(2)(NMe(2))(6) and 2,2'-methylenebis(6-tert-butyl-4-methylphenol) (>/=2 equiv), HO&ndblwave;CH(2)&ndblwave;OH, yield Mo(2)(NMe(2))(2)(O&ndblwave;CH(2)&ndblwave;O)(2), I, which exists in bridged Ib and chelated Ic isomers. These are formed under kinetic control, and recrystallization allows the separation of Ib (orange cubes) from Ic (yellow cubes) both of which have been crystallographically characterized. In each there is an ethane-like O(2)NMo&tbd1;MoO(2)N core with Mo-Mo = 2.2 Å (average). In Ib the two O&ndblwave;CH(2)&ndblwave;O ligands span the Mo&tbd1;Mo bond yielding a molecule of C(2) symmetry. In Ic the molecule has near-C(2) symmetry in the solid state, but in solution there is either rapid rotation about the M&tbd1;M bond or the anti-rotamer is preferred. In benzene-d(6), Ib and Ic do not interconvert at 110 degrees C over a period of days. However, the addition of pyridine or acetonitrile causes the isomerization of Ib to Ic, thereby establishing that Ic is the thermodynamic isomer. The rate of conversion of Ib to Ic has been shown to be dependent on the square of the concentration of added pyridine: k(obs) = k[py](2). From the temperature dependence of k(obs), we determine DeltaH() = 19 (+/-1) kcal/mol and DeltaS() = -25 (+/-3) eu for the pyridine-promoted isomerization of Ib to Ic. The related reaction involving W(2)(NMe(2))(6) and HO&ndblwave;CH(2)&ndblwave;OH (>/=2 equiv) in hydrocarbon solvents at room temperature and below yields a dark brown crystalline compound, wherein C-H activation has occurred at one of the O&ndblwave;CH(2)&ndblwave;O diolate ligands, W(2)(&mgr;-H)(&mgr;-NMe(2))(NMe(2))(eta(2)-O&ndblwave;CH(2)&ndblwave;O)(eta(3)-O&ndblwave;CH&ndblwave;O)(HNMe(2)), 2. The W-W distance in 2 is 2.495(1) Å, consistent with a (W=W)(8+) core. Heating 2 in the solid-state under a dynamic vacuum leads to the elimination of HNMe(2) and the formation of 3, W(2)(NMe(2))(2)(eta(2)-O&ndblwave;CH(2)&ndblwave;O)(2), an analog

Diversity of human immunodeficiency virus type 1 subtypes in Kagera and Kilimanjaro regions, Tanzania.

PubMed

Nyombi, Balthazar M; Kristiansen, Knut I; Bjune, Gunnar; Müller, Fredrik; Holm-Hansen, Carol

2008-06-01

A strategy to prevent the spread of HIV-1 worldwide is complicated by the high genetic diversity of the virus. To gain a better understanding of the HIV-1 genetic diversity in Tanzania, a molecular epidemiological investigation was conducted in Kagera and Kilimanjaro regions. While several studies have addressed HIV-1 subtypes in Tanzania, this is the first study to describe the virus subtypes circulating in Kagera. The Kagera region is the epicenter of the HIV-1 epidemic in Africa, and it was therefore of interest to compare the prevalence of HIV subtypes in this region and Kilimanjaro. Blood samples were obtained from 246 HIV-1-infected pregnant women attending antenatal clinics. Plasma HIV-1 RNA was extracted, amplified, and sequenced in the env C2V3 and/or pol regions from 209 samples. Based on the analysis of env C2V3 and pol sequences, 47.4% had concordant subtypes, 19.1% were discordant indicating recombination, and for 33.5% sequences were obtained for only one region. The distribution HIV-1 subtypes based on the phylogenetic analysis of paired env C2V3/ pol sequences in Kagera region was A/A (27.8%), C/C (29.6%), D/D (16.7%), and unique recombinant forms (25.9%), and in Kilimanjaro region was A/A (32.9%), C/C (25.9%), D/D (10.6%), CRF10_CD (1.2%), and unique recombinant forms (29.4%). The env C2V3 subsubtype A2 and env C2V3/pol CRF10_CD were also observed indicating that these recombinants are circulating in Tanzania. The high diversity of HIV-1 subtypes and the high prevalence of recombinants demonstrated in this study necessitate expanded and continuous monitoring of the epidemic in Tanzania. The trend may have implications for current national control strategies against the HIV-1 epidemic.

Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.

PubMed

Dallol, Ashraf; Forgacs, Eva; Martinez, Alonso; Sekido, Yoshitaka; Walker, Rosemary; Kishida, Takeshi; Rabbitts, Pamela; Maher, Eamonn R; Minna, John D; Latif, Farida

2002-05-02

The human homologue of the Drosophila Roundabout gene DUTT1 (Deleted in U Twenty Twenty) or ROBO1 (Locus Link ID 6091), a member of the NCAM family of receptors, was recently cloned from the lung cancer tumour suppressor gene region 2 (LCTSGR2 or U2020 region) at 3p12. DUTT1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer lines (SCLC) and in a breast cancer line. In this report we (a) defined the genomic organization of the DUTT1 gene, (b) performed mutation and expression analysis of DUTT1 in lung, breast and kidney cancers, (c) identified tumour specific promoter region methylation of DUTT1 in human cancers. The gene was found to contain 29 exons and spans at least 240 kb of genomic sequence. The 5' region contains a CpG island, and the poly(A)(+) tail has an atypical 5'-GATAAA-3' signal. We analysed DUTT1 for mutations in lung, breast and kidney cancers, no inactivating mutations were detected by PCR-SSCP. However, seven germline missense changes were found and characterized. DUTT1 expression was not detectable in one out of 18 breast tumour lines analysed by RT-PCR. Bisulfite sequencing of the promoter region of DUTT1 gene in the HTB-19 breast tumour cell line (not expressing DUTT1) showed complete hypermethylation of CpG sites within the promoter region of the DUTT1 gene (-244 to +27 relative to the translation start site). The expression of DUTT1 gene was reactivated in HTB-19 after treatment with the demethylating agent 5-aza-2'-deoxycytidine. The same region was also found to be hypermethylated in six out of 32 (19%) primary invasive breast carcinomas and eight out of 44 (18%) primary clear cell renal cell carcinomas (CC-RCC) and in one out of 26 (4%) primary NSCLC tumours. Furthermore 80% of breast and 75% of CC-RCC tumours showing DUTT1 methylation had allelic losses for 3p12 markers hence obeying Knudson's two hit hypothesis. Our findings suggest that DUTT1 warrants further analysis as a candidate for

Defense Acquisitions: Assessments of Selected Weapon Programs

DTIC Science & Technology

2017-03-01

PAC-3 MSE) 81 Warfighter Information Network-Tactical (WIN-T) Increment 2 83 Improved Turbine Engine Program (ITEP) 85 Long Range Precision Fires...Unmanned Air System 05/2018 —- O  Joint Surveillance Target Attack Radar System Recapitalization 10/2017 —- O  Improved Turbine Engine Program TBD...Network-Tactical (WIN-T) Increment 2 83 1-page assessments Improved Turbine Engine Program (ITEP) 85 Long Range Precision Fires (LRPF) 86

Identification of two allelic IgG1 C(H) coding regions (Cgamma1) of cat.

PubMed

Kanai, T H; Ueda, S; Nakamura, T

2000-01-31

Two types of cDNA encoding IgG1 heavy chain (gamma1) were isolated from a single domestic short-hair cat. Sequence analysis indicated a higher level of similarity of these Cgamma1 sequences to human Cgamma1 sequence (76.9 and 77.0%) than to mouse sequence (70.0 and 69.7%) at the nucleotide level. Predicted primary structures of both the feline Cgamma1 genes, designated as Cgamma1a and Cgamma1b, were similar to that of human Cgamma1 gene, for instance, as to the size of constant domains, the presence of six conserved cysteine residues involved in formation of the domain structure, and the location of a conserved N-linked glycosylation site. Sequence comparison between the two alleles showed that 7 out of 10 nucleotide differences were within the C(H)3 domain coding region, all leading to nonsynonymous changes in amino acid residues. Partial sequence analysis of genomic clones showed three nucleotide substitutions between the two Cgamma1 alleles in the intron between the CH2 and C(H)3 domain coding regions. In 12 domestic short-hair cats used in this study, the frequency of Cgamma1a allele (62.5%) was higher than that of the Cgamma1b allele (37.5%).

Common variants in the HLA-DRB1-HLA-DQA1 Class II region are associated with susceptibility to visceral leishmaniasis

PubMed Central

Fakiola, Michaela; Strange, Amy; Cordell, Heather J.; Miller, E. Nancy; Pirinen, Matti; Su, Zhan; Mishra, Anshuman; Mehrotra, Sanjana; Monteiro, Gloria R.; Band, Gavin; Bellenguez, Céline; Dronov, Serge; Edkins, Sarah; Freeman, Colin; Giannoulatou, Eleni; Gray, Emma; Hunt, Sarah E.; Lacerda, Henio G.; Langford, Cordelia; Pearson, Richard; Pontes, Núbia N.; Rai, Madhukar; Singh, S.P.; Smith, Linda; Sousa, Olivia; Vukcevic, Damjan; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S.; Mathew, Christopher G.; Palmer, Colin N.A.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Wood, Nicholas W.; Wilson, Mary E.; Deloukas, Panos; Peltonen, Leena; Christiansen, Frank; Witt, Campbell; Jeronimo, Selma M.B.; Sundar, Shyam; Spencer, Chris C.A.; Blackwell, Jenefer M.; Donnelly, Peter

2013-01-01

To identify susceptibility loci for visceral leishmaniasis we undertook genome-wide association studies in two populations; 989 cases and 1089 controls from India, and 357 cases in 308 Brazilian families (1970 individuals). The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this region was undertaken in a second Indian population comprising 941 cases and 990 controls, resulting in Pcombined=2.76×10−17 and OR(95%CI)=1.41(1.30-1.52) across the three cohorts at rs9271858. A conditional analysis provided evidence for multiple associations within the HLA-DRB1-HLA-DQA1 region, and a model in which risk differed between three groups of haplotypes better explained the signal and was significant in the Indian discovery and replication cohorts. In conclusion the HLA-DRB1-HLA-DQA1 HLA class II region contributes to visceral leishmaniasis susceptibility in India and Brazil, suggesting shared genetic risk factors for visceral leishmaniasis that cross the epidemiological divides of geography and parasite species. PMID:23291585

AgMIP Coordinated Global and Regional Assessments for 1.5°C and 2.0°C

NASA Astrophysics Data System (ADS)

Rosenzweig, C.

2017-12-01

The Agricultural Model Intercomparison and Improvement Project (AgMIP) has developed novel methods for Coordinated Global and Regional Assessments (CGRA) of agriculture and food security in a changing world. The present study performs a proof-of-concept of the CGRA to demonstrate advantages and challenges of the framework. This effort responds to the request by UNFCCC for the implications of limiting global temperature increases to 1.5°C and 2.0°C above pre-industrial conditions. The protocols for the 1.5°C/2.0°C assessment establish explicit and testable linkages across disciplines and scales, connecting outputs and inputs from the Shared Socio-economic Pathways (SSPs), Representative Agricultural Pathways (RAPs), HAPPI and CMIP5 ensemble scenarios, global gridded crop models, global agricultural economic models, site-based crop models, and within-country regional economic models. CGRA results show that at the global scale, mixed areas of positive and negative simulated yield changes, with declines in some breadbasket regions led to overall declines in productivity at both 1.5°C and 2.0°C. These projected global yield changes resulted in increases in prices of major commodities in a global economic model. Simulations for 1.5°C and 2.0°C using site-based crop models had mixed results depending on region and crop, but with more negative effects on productivity at 2.0°C than at 1.5°C for the most part. In conjunction with price changes from the global economics models, these productivity declines resulted generally in small positive effects on regional farm livelihoods, showing that farming systems should continue to be viable under high mitigation scenarios. CGRA protocols focus on how mitigation actions and effects differ across scales, with main mechanisms studied in the integrated assessment models being policies and technologies that reduce direct non-CO2 emissions from agriculture, reduce CO2 emissions from land use change and forest sink enhancement

Level IV Ecoregions of EPA Region 1

EPA Pesticide Factsheets

Ecoregions by EPA region were extracted from the seamless national shapefile. Ecoregions denote areas of general similarity in ecosystems and in the type, quality, and quantity of environmental resources. They are designed to serve as a spatial framework for the research, assessment, management, and monitoring of ecosystems and ecosystem components. These general purpose regions are critical for structuring and implementing ecosystem management strategies across federal agencies, state agencies, and nongovernment organizations that are responsible for different types of resources within the same geographical areas. The approach used to compile this map is based on the premise that ecological regions can be identified through the analysis of patterns of biotic and abiotic phenomena, including geology, physiography, vegetation, climate, soils, land use, wildlife, and hydrology. The relative importance of each characteristic varies from one ecological region to another. A Roman numeral hierarchical scheme has been adopted for different levels for ecological regions. Level I is the coarsest level, dividing North America into 15 ecological regions. Level II divides the continent into 52 regions (Commission for Environmental Cooperation Working Group, 1997). At Level III, the continental United States contains 104 regions whereas the conterminous United States has 84 (U.S. Environmental Protection Agency, 2005). Level IV ecoregions are further subdivisions of Level I

Level III Ecoregions of EPA Region 1

EPA Pesticide Factsheets

Ecoregions by EPA region were extracted from the seamless national shapefile. Ecoregions denote areas of general similarity in ecosystems and in the type, quality, and quantity of environmental resources. They are designed to serve as a spatial framework for the research, assessment, management, and monitoring of ecosystems and ecosystem components. These general purpose regions are critical for structuring and implementing ecosystem management strategies across federal agencies, state agencies, and nongovernment organizations that are responsible for different types of resources within the same geographical areas. The approach used to compile this map is based on the premise that ecological regions can be identified through the analysis of patterns of biotic and abiotic phenomena, including geology, physiography, vegetation, climate, soils, land use, wildlife, and hydrology. The relative importance of each characteristic varies from one ecological region to another. A Roman numeral hierarchical scheme has been adopted for different levels for ecological regions. Level I is the coarsest level, dividing North America into 15 ecological regions. Level II divides the continent into 52 regions (Commission for Environmental Cooperation Working Group, 1997). At Level III, the continental United States contains 104 regions whereas the conterminous United States has 84 (U.S. Environmental Protection Agency, 2005). Level IV ecoregions are further subdivisions of Level I

75 FR 39029 - Subcommittee on Procedures Review, Advisory Board on Radiation and Worker Health (ABRWH...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... Angular Response of NTA Film on Missed Neutron Dose at the Oak Ridge Y-12 Facility''), OTIB-0054... Atomic Weapons Employer Facilities''), and TBD 6000 (``Site Profile for Atomic Weapons Employers that...

Shallow Water MCM and ASW Using Off-Board, Autonomous Sensor Networks and Multistatic, Time-Reversal Acoustics

DTIC Science & Technology

2005-09-30

generalizations of auto-focusing and track - before - detect (TBD) algorithms. Another issue concerns the stability and coherence of surface and seabed multiples and their potential use in advanced medium-frequency sonar concepts.

Draft Genome Sequence of Haloferax sp. Strain ATB1, Isolated from a Semi-Arid Region in the Brazilian Caatinga.

PubMed

Castro, Wendel de Oliveira; Torres-Ballesteros, Adriana Maria; Nakayama, Cristina Rossi; Melo, Itamar Soares; Pellizari, Vivian Helena; Silva, Artur; Ramos, Rommel Thiago Jucá

2014-08-14

Organisms in the Haloferax genus are extreme halophiles that grow in environments with pH values between 4 and 12, and temperatures between 0°C and 60°C. In the present study, a draft of the first Haloferax sp. strain ATB1 genome isolated from the region of Cariri (in Paraíba State, Brazil) is presented. Copyright © 2014 Castro et al.

Symptom presentations and other characteristics of colorectal cancer patients and the diagnostic performance of the Auckland Regional Grading Criteria for Suspected Colorectal Cancer in the South Auckland population.

PubMed

Hsiang, John C; Bai, Wayne; Lal, Dinesh

2013-09-13

This study reviews the presenting symptoms of colorectal cancer in the ethnically diverse Middlemore Hospital referral population of South Auckland, New Zealand. The performance of the newly introduced Auckland Regional Grading Criteria as prediction tool for selecting colorectal cancer cases referred from primary care was evaluated in this group. Retrospective review of all colorectal cancer (CRC) cases diagnosed between January 2006 and January 2011. Information extracted from case note review was used to grade patients using the Auckland Regional Grading Criteria. A total of 799 patients were included. The commonest symptoms were: rectal bleeding (25.5-42.3%) and change in bowel habit (20.6-26.8%). Low-risk symptoms including abdominal pain (16.3-46.8%) and weight loss (18.4-26.1%) were not uncommon. 64.4% of Maori and 64.9% of Pacific patients had stage III or IV cancers. Pacific patients had more stage IV disease, 37.7% (p<0.001) and were less likely to undergo tumour resection, 26.0% (p<0.001). The Auckland Regional Grading Criteria would miss 24.7% of the patients with CRC in the referral population. While rectal bleeding and change in bowel habit are frequent presenting symptoms, low-risk atypical symptoms including constipation, weight loss and abdominal pain were not uncommon. Significant proportion of Pacific patients present with late-stage disease. The current Auckland Regional grading criteria would miss significant proportion of our study population with colorectal cancer.

Geologic Map of the Snegurochka Planitia Quadrangle (V-1): Implications for Tectonic and Volcanic History of the North Polar Region of Venus

NASA Technical Reports Server (NTRS)

Hurwitz, D. M.; Head, J. W.

2009-01-01

Geologic mapping of Snegurochka Planitia (V-1) reveals a complex stratigraphy of tectonic and volcanic features that can provide insight into the geologic history of Venus and Archean Earth [1,2], including 1) episodes of both localized crustal uplift and mantle downwelling, 2) shifts from local to regional volcanic activity, and 3) a shift back to local volcanic activity. We present our progress in mapping the spatial and stratigraphic relationships of material units and our initial interpretations of the tectonic and volcanic history of the region surrounding the north pole of Venus

Distribution of Region 1 and 2 currents in the quietand substorm time plasma sheetfrom THEMIS observations

NASA Astrophysics Data System (ADS)

Liu, J.; Angelopoulos, V.; Chu, X.; McPherron, R. L.

2016-12-01

Although Earth's Region 1 and 2 currents are related to activities such as substorm initiation, their magnetospheric origin remains unclear. Utilizing the triangular configuration of THEMIS probes at 8-12 RE downtail, we seek the origin of nightside Region 1 and 2 currents. The triangular configuration allows a curlometer-like technique which do not rely on active-time boundary crossings, so we can examine the current distribution in quiet times as well as active times. Our statistical study reveals that both Region 1 and 2 currents exist in the plasma sheet during quiet and active times. Especially, this is the first unequivocal, in-situ evidence of the existence of Region 2 currents in the plasma sheet. Farther away from the neutral sheet than the Region 2 currents lie the Region 1 currents which extend at least to the plasma sheet boundary layer. At geomagnetic quiet times, the separation between the two currents is located 2.5 RE from the neutral sheet. These findings suggest that the plasma sheet is a source of Region 1 and 2 currents regardless of geomagnetic activity level. During substorms, the separation between Region 1 and 2 currents migrates toward (away from) the neutral sheet as the plasma sheet thins (thickens). This migration indicates that the deformation of Region 1 and 2 currents is associated with redistribution of FAC sources in the magnetotail. In some substorms when the THEMIS probes encounter a dipolarization, a substorm current wedge (SCW) can be inferred from our technique, and it shows a distinctively larger current density than the pre-existing Region 1 currents. This difference suggests that the SCW is not just an enhancement of the pre-existing Region 1 current; the SCW and the Region 1 currents have different sources.

Statistical modelling of grapevine yield in the Port Wine region under present and future climate conditions

NASA Astrophysics Data System (ADS)

Santos, João A.; Malheiro, Aureliano C.; Karremann, Melanie K.; Pinto, Joaquim G.

2011-03-01

The impact of projected climate change on wine production was analysed for the Demarcated Region of Douro, Portugal. A statistical grapevine yield model (GYM) was developed using climate parameters as predictors. Statistically significant correlations were identified between annual yield and monthly mean temperatures and monthly precipitation totals during the growing cycle. These atmospheric factors control grapevine yield in the region, with the GYM explaining 50.4% of the total variance in the yield time series in recent decades. Anomalously high March rainfall (during budburst, shoot and inflorescence development) favours yield, as well as anomalously high temperatures and low precipitation amounts in May and June (May: flowering and June: berry development). The GYM was applied to a regional climate model output, which was shown to realistically reproduce the GYM predictors. Finally, using ensemble simulations under the A1B emission scenario, projections for GYM-derived yield in the Douro Region, and for the whole of the twenty-first century, were analysed. A slight upward trend in yield is projected to occur until about 2050, followed by a steep and continuous increase until the end of the twenty-first century, when yield is projected to be about 800 kg/ha above current values. While this estimate is based on meteorological parameters alone, changes due to elevated CO2 may further enhance this effect. In spite of the associated uncertainties, it can be stated that projected climate change may significantly benefit wine yield in the Douro Valley.

75 FR 67698 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-03

.... Title, Form, and OMB Number: Leading Edge Supply Chain Survey; OMB Number 0701-TBD. Type of Request: New... uncover the emerging trends in supply chain management (SCM) practices, processes and metrics that could...

Multiferroic homochiral metal-organic framework.

PubMed

Ye, Qiong; Fu, Da-Wei; Tian, Hang; Xiong, Ren-Gen; Chan, Philip Wai Hong; Huang, Songping D

2008-02-04

The hydrothermal reaction of (L)-ethyl lactate (Lig-Et) with Tb(ClO(4))(3).6H(2)O gives colorless block (Lig)(2)Tb(H(2)O)(2)(ClO(4)) (1), in which 1 displays a laminar 2D framework. Ferroelectric and magnetic property measurements reveal that 1 probably is the first example of two "ferroic" metal-organic frameworks. Ferroelectricity of its analogue, (Lig)(2)Tb(D(2)O)(2)(ClO(4)) (2), further confirms the presence of the ferroelectric deuterium effect.

Identification of an immunodominant region of Fel d 1 and characterization of constituent epitopes.

PubMed

Bateman, E A L; Ardern-Jones, M R; Ogg, G S

2008-11-01

Characterization of T cell epitopes restricted by common HLA alleles is a powerful tool in the understanding of the immune responses to allergens and for the identification of potential peptides for future peptide immunotherapy (PIT). One important requirement is the identification and use of peptides that will bind to HLA molecules covering a large proportion of the population. To identify commonly recognized CD4(+) T cell epitopes in Fel d 1, restricted through frequently expressed HLA molecules for potential future use in PIT. HLA matched antigen presenting cells, HLA blocking antibodies, and peptide truncations were used in ELISpot assays to establish HLA-restricted T cell epitopes. Cytokine responses were measured by ex vivo and cultured IFN-gamma, IL-4, and IL-10 ELISpots. Responses to an immunodominant region of chain 2 were identified in the majority of atopic individuals and epitopes restricted by HLA-DQB1(*)06 and -DPB1(*)0401 were characterized in detail. Significantly higher ex vivo IL-4 and lower IFN-gamma responses were observed to both epitopes in individuals with atopic dermatitis (AD) compared with those without disease. IL-10 responses were significantly lower in those with AD in the individuals with HLA-DPB1(*)0401. We have identified an immunodominant region of Fel d 1 which is frequently recognized by CD4(+) T cells from atopic individuals and contains epitopes that are restricted by very common HLA alleles.

Complex multiple antibiotic and mercury resistance region derived from the r-det of NR1 (R100).

PubMed

Partridge, Sally R; Hall, Ruth M

2004-11-01

The sequence of the 45.2-kb multidrug and mercury resistance region of pRMH760, a large plasmid from a clinical isolate of Klebsiella pneumoniae collected in 1997 in Australia, was completed. Most of the modules found in the resistance determinant (r-det), or Tn2670, region of NR1 (also known as R100), isolated from a Shigella flexneri strain in Japan in the late 1950s, were present in pRMH760 but in a different configuration. The location was also different, with the Tn2670-derived region flanked by the transposition module of Tn1696 and a mercury resistance module almost identical to one found in the plasmid pDU1358. This arrangement is consistent with a three-step process. First, the r-det was circularized via homologous recombination between the IS1 elements and reincorporated at a new location, possibly in a different plasmid, via homologous recombination between the 5'-conserved (5'-CS) or 3'-CS of the In34 integron in the r-det and the same region of a second class 1 integron in a Tn1696 relative. Subsequently, resolvase-mediated recombination between the res sites in the r-det and a second mercury resistance transposon removed one end of the Tn1696-like transposon and part of the second transposon. Other events occurring within the r-det-derived portion have also contributed to the formation of the pRMH760 resistance region. Tn2 or a close relative that includes the bla(TEM-1b) gene had moved into the Tn21 mercury resistance module with subsequent deletion of the adjacent sequence, and all four 38-bp inverted repeats corresponding to Tn21 family transposon termini have been interrupted by an IS4321-like element.

Energetic-ion acceleration and transport in the upstream region of Jupiter: Voyager 1 and 2

NASA Technical Reports Server (NTRS)

Baker, D. N.; Zwickl, R. D.; Carbary, J. F.; Krimigis, S. M.; Lepping, R. P.

1982-01-01

Long-lived upstream energetic ion events at Jupiter appear to be very similar in nearly all respects to upstream ion events at Earth. A notable difference between the two planetary systems is the enhanced heavy ion compositional signature reported for the Jovian events. This compositional feature has suggested that ions escaping from the Jovian magnetosphere play an important role in forming upstream ion populations at Jupiter. In contrast, models of energetic upstream ions at Earth emphasize in situ acceleration of reflected solar wind ions within the upstream region itself. Using Voyager 1 and 2 energetic ( approximately 30 keV) ion measurements near the magnetopause, in the magnetosheath, and immediately upstream of the bow shock, the compositional patterns are examined together with typical energy spectra in each of these regions. A model involving upstream Fermi acceleration early in events and emphasizing energetic particle escape in the prenoon part of the Jovian magnetosphere late in events is presented to explain many of the features in the upstream region of Jupiter.

Analysis of tissue-specific region in sericin 1 gene promoter of Bombyx mori

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu Yan; Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031; Yu Lian

The gene encoding sericin 1 (Ser1) of silkworm (Bombyx mori) is specifically expressed in the middle silk gland cells. To identify element involved in this transcription-dependent spatial restriction, truncation of the 5' terminal from the sericin 1 (Ser1) promoter is studied in vivo. A 209 bp DNA sequence upstream of the transcriptional start site (-586 to -378) is found to be responsible for promoting tissue-specific transcription. Analysis of this 209 bp region by overlapping deletion studies showed that a 25 bp region (-500 to -476) suppresses the ectopic expression of the Ser1 promoter. An unknown factor abundant in fat bodymore » nuclear extracts is shown to bind to this 25 bp fragment. These results suggest that this 25 bp region and the unknown factor are necessary for determining the tissue-specificity of the Ser1 promoter.« less

Desert Peak East Enhanced Geothermal Systems (EGS) Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zemach, Ezra; Drakos, Peter; Spielman, Paul

2013-09-30

This manuscript is a draft to replaced with a final version at a later date TBD. A summary of activities pertaining to the Desert Peak EGS project including the planning and resulting stimulation activities.

Manpower and the Minority Student. Regional Spotlight Vol. XI, No. 1.

ERIC Educational Resources Information Center

Anderson, Laura

Market saturation and diminishing opportunities are imminent in fields heavily favored by blacks in college: the social sciences, home economics and education. Future opportunities will come in fields presently unpopular or unknown to blacks: engineering, accounting, library science, urban and regional planning, health professions, and computer…

The T-cell receptor beta chain CDR3 region of BV8S1/BJ1S5 transcripts in type 1 diabetes.

PubMed

Naserke, H E; Durinovic-Bellò, I; Seidel, D; Ziegler, A G

1996-01-01

We recently described the T-cell receptor (TCR) beta chain CDR3 motif S-SDRLG-NQPQH (BV8S1-BJ1S5) in an islet-specific T-cell clone (K2.12) from a type 1 diabetic patient (AS). A similar motif (RLGNQ) was also reported in a T-cell clone of non-obese diabetic (NOD) mice by others. In order to determine the frequency of our motif in selected and unselected T-cell populations, we cloned and sequenced the CDR3 region of BV8S1-BJ1S5 transcripts. These transcripts were derived from unstimulated peripheral blood T lymphocytes from two type 1 diabetic patients (AS and FS) and their non-diabetic sibling (WS), as well as from an islet-specific T-cell line of one of the patients. In addition, we compared the structure and composition of the CDR3 region in BV8S1-BJ1S5 transcripts from peripheral blood T cells between the patients and their non-diabetic sibling (>50 sequences each). We found that 30% of the islet-specific T-cell line cDNA clones expressed the entire sequence-motif, whereas it was absent in the clones of unstimulated peripheral blood T cells from both patients and their non-diabetic sibling. The average length of the CDR3 region was shorter in the patients (mean AS 9.9, FS 9.9, versus WS 10.7, p = 0.0037) and the number of inserted nucleotides in N nucleotide addition at the DJ-junction lower (mean AS 3.5, FS 3. 2, versus WS 5.2, P = <10(-4)) as compared with their non-diabetic sibling. Moreover, the pattern of amino acid usage in the CDR3 region was dissimilar at positions 5 and 6, where polar amino acids predominated in both diabetic siblings. In contrast, basic amino acids are preferentially used at position 5 in the clones of the non-diabetic sibling. These data provide information on the general structure of the TCR(BV8S1-BJ1S5) CDR3 region in type 1 diabetes and may indicate differences in the amino and nucleic acid composition of the TCR beta chain CDR3 region between two type 1 diabetic patients and their non-diabetic sibling.

Upward electron beams measured by DE-1 - A primary source of dayside region-1 Birkeland currents

NASA Technical Reports Server (NTRS)

Burch, J. L.; Reiff, P. H.; Sugiura, M.

1983-01-01

Measurements made by the High Altitude Plasma Instrument on DE-1 have shown that intense upward electron beams with energies from about 20 eV to about 200 eV are a common feature of the region just equatorward of the morning-side polar cusp. Computations of the currents carried by these beams and by the precipitating cusp electrons show excellent agreement with the simultaneous DE-1 magnetometer measurements for both upward and downward Birkeland currents. The data indicate that cold ionospheric electrons, which carry the downward region-1 Birkeland currents on the morning side, are accelerated upward by potential drops of a few tens of eV at altitudes of several thousand kilometers. This acceleration process allows spacecraft above those altitudes to measure routinely the charge carriers of both downward and upward current systems.

Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene.

PubMed

Tan-Wong, Sue Mei; French, Juliet D; Proudfoot, Nicholas J; Brown, Melissa A

2008-04-01

The 85-kb breast cancer-associated gene BRCA1 is an established tumor suppressor gene, but its regulation is poorly understood. We demonstrate by gene conformation analysis in both human cell lines and mouse mammary tissue that gene loops are imposed on BRCA1 between the promoter, introns, and terminator region. Significantly, association between the BRCA1 promoter and terminator regions change upon estrogen stimulation and during lactational development. Loop formation is transcription-dependent, suggesting that transcriptional elongation plays an active role in BRCA1 loop formation. We show that the BRCA1 terminator region can suppress estrogen-induced transcription and so may regulate BRCA1 expression. Significantly, BRCA1 promoter and terminator interactions vary in different breast cancer cell lines, indicating that defects in BRCA1 chromatin structure may contribute to dysregulated expression of BRCA1 seen in breast tumors.

Vital: Vanguard Investigations of Therapeutic Approaches to Lung Cancer

DTIC Science & Technology

2007-01-01

corresponding AIC values were We analyzed these data sets using different methods . We -106.28, -106.39, and -106.72, respectively. The backward calculated the...old 8 considerable progress in generating 60-70 years old 11 immortalized HBECs from now 36 >70 years old 9 different individuals that were Age TBD 5...Aim 1. We will determine the potential role of different chemopreventive agents [e.g., celecoxib, N-(4- hydroxyphenyl]retinamide (4-HPR), Iressa

Regional assessment of aquifers for thermal energy storage. Volume 1: Regions 1 through 6

NASA Astrophysics Data System (ADS)

1981-06-01

The geologic and hydrologic framework, major aquifers, aquifers which are suitable and unsuitable for annual thermal energy storage (ATES) and the ATES potential of the western mountains, alluvial basins, Columbia LAVA plateau, Colorado plateau, high plains, and glaciated central region are discussed.

Clinical presentation of Lyme disease in the higher-risk region of Quebec: a retrospective descriptive study.

PubMed

Charbonneau, Audrey; Charette, Louis-Philippe; Rouleau, Geneviève; Savary, Mélissa; Wilson, Alexandra; Heer, Emily; Bériault, Karine; de Pokomandy, Alexandra

2018-03-23

Lyme disease is emerging in Canada. This study aimed to describe the use of serologic testing for the disease in the La Pommeraie health region in southern Quebec between 2012 and 2015 and to describe the clinical presentation of laboratory-confirmed cases. The medical charts of all patients investigated for Lyme disease at the Brome-Missisquoi-Perkins Hospital's laboratory between 2012 and 2015 were reviewed for results of serologic testing. Laboratory diagnosis was based on 2-tiered testing: cases had to have positive results of both the enzyme immunoassay and the Western blot test (IgM or IgG). We collected data on clinical presentation for patients assessed at the hospital or at the La Pommeraie Family Medicine Unit. Over the study period, 720 patients were investigated for Lyme disease. There was a more than fivefold increase in requests for serologic testing from 2012 (53) to 2015 (273). The number of confirmed cases increased from 2012 (3) to 2013 (19) and remained stable thereafter (19 in 2014, 18 in 2015). Fifty patients were positive for IgM with or without IgG positivity, and 9 patients were IgG-positive only. Chart reviews were completed for 278 of the 720 patients, including 38 of the 59 laboratory-confirmed cases. Among the 29 IgM-positive patients, the most common symptoms were fever (17 patients [59%]), fatigue (14 [48%]), myalgia (12 [41%]) and headaches (10 [34%]). Twenty-three (79%) had some cutaneous manifestation, including specifically erythema migrans (14 [48%]). A tick bite was reported by 11 patients (38%). Of the 44 patients in the entire study population who presented with erythema migrans, 15 (34%) had confirmed Lyme disease. Requests for serologic testing for Lyme disease increased in the La Pommeraie health region over recent years. Cutaneous manifestations, fever and myalgia were the most common symptoms of IgM-positive cases. Most patients did not report a tick bite. Copyright 2018, Joule Inc. or its licensors.

Clinical presentation of Lyme disease in the higher-risk region of Quebec: a retrospective descriptive study

PubMed Central

Charbonneau, Audrey; Charette, Louis-Philippe; Rouleau, Geneviève; Savary, Mélissa; Wilson, Alexandra; Heer, Emily; Bériault, Karine; de Pokomandy, Alexandra

2018-01-01

Background: Lyme disease is emerging in Canada. This study aimed to describe the use of serologic testing for the disease in the La Pommeraie health region in southern Quebec between 2012 and 2015 and to describe the clinical presentation of laboratory-confirmed cases. Methods: The medical charts of all patients investigated for Lyme disease at the Brome-Missisquoi-Perkins Hospital's laboratory between 2012 and 2015 were reviewed for results of serologic testing. Laboratory diagnosis was based on 2-tiered testing: cases had to have positive results of both the enzyme immunoassay and the Western blot test (IgM or IgG). We collected data on clinical presentation for patients assessed at the hospital or at the La Pommeraie Family Medicine Unit. Results: Over the study period, 720 patients were investigated for Lyme disease. There was a more than fivefold increase in requests for serologic testing from 2012 (53) to 2015 (273). The number of confirmed cases increased from 2012 (3) to 2013 (19) and remained stable thereafter (19 in 2014, 18 in 2015). Fifty patients were positive for IgM with or without IgG positivity, and 9 patients were IgG-positive only. Chart reviews were completed for 278 of the 720 patients, including 38 of the 59 laboratory-confirmed cases. Among the 29 IgM-positive patients, the most common symptoms were fever (17 patients [59%]), fatigue (14 [48%]), myalgia (12 [41%]) and headaches (10 [34%]). Twenty-three (79%) had some cutaneous manifestation, including specifically erythema migrans (14 [48%]). A tick bite was reported by 11 patients (38%). Of the 44 patients in the entire study population who presented with erythema migrans, 15 (34%) had confirmed Lyme disease. Interpretation: Requests for serologic testing for Lyme disease increased in the La Pommeraie health region over recent years. Cutaneous manifestations, fever and myalgia were the most common symptoms of IgM-positive cases. Most patients did not report a tick bite. PMID:29588280

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.

PubMed

Fakiola, Michaela; Strange, Amy; Cordell, Heather J; Miller, E Nancy; Pirinen, Matti; Su, Zhan; Mishra, Anshuman; Mehrotra, Sanjana; Monteiro, Gloria R; Band, Gavin; Bellenguez, Céline; Dronov, Serge; Edkins, Sarah; Freeman, Colin; Giannoulatou, Eleni; Gray, Emma; Hunt, Sarah E; Lacerda, Henio G; Langford, Cordelia; Pearson, Richard; Pontes, Núbia N; Rai, Madhukar; Singh, Shri P; Smith, Linda; Sousa, Olivia; Vukcevic, Damjan; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin N A; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J; Trembath, Richard C; Viswanathan, Ananth C; Wood, Nicholas W; Wilson, Mary E; Deloukas, Panos; Peltonen, Leena; Christiansen, Frank; Witt, Campbell; Jeronimo, Selma M B; Sundar, Shyam; Spencer, Chris C A; Blackwell, Jenefer M; Donnelly, Peter

2013-02-01

To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 cases and 1,089 controls from India and 357 cases in 308 Brazilian families (1,970 individuals). The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this region was undertaken in a second Indian population comprising 941 cases and 990 controls, and combined analysis across the three cohorts for rs9271858 at this locus showed P(combined) = 2.76 × 10(-17) and odds ratio (OR) = 1.41, 95% confidence interval (CI) = 1.30-1.52. A conditional analysis provided evidence for multiple associations within the HLA-DRB1-HLA-DQA1 region, and a model in which risk differed between three groups of haplotypes better explained the signal and was significant in the Indian discovery and replication cohorts. In conclusion, the HLA-DRB1-HLA-DQA1 HLA class II region contributes to visceral leishmaniasis susceptibility in India and Brazil, suggesting shared genetic risk factors for visceral leishmaniasis that cross the epidemiological divides of geography and parasite species.

Effects of treatment on free radicals in patients with pulmonary tuberculosis in South Western Nigeria.

PubMed

Adebimpe, Wasiu Olalekan; Faremi, Ayodeji Oluwaseun; Nassar, Sulaiman Adebayo

2015-12-01

Formation of Malondialdehyde (MDA), a free radical, in Tuberculosis patients does occur when Tubercule bacilli induces reactive oxygen species as a result of phagocytic respiratory burst. This study evaluated the effect of treatment on plasma level of Malondialdehyde among patients infected with Mycobacterium Tuberculosis in Osogbo South Western Nigeria. Descriptive cross sectional study among 110 patients, grouped into four categories (three TB patient categories and controls). All patients were screened for presence or absence of Mycobacterium tuberculosis in their sputum and HIV 1 & 2 in their blood using standard techniques. The level of free radical (Malondialdehyde, MDA) was determined by Thiobabituric acid reacting method. Data was analyzed using the SPSS software version 17.0. Serum Malondialdehyde (MDA) levels were significantly lower in TB patients on drugs (TBD) compared with the new cases on treatment (NCT). (0.17+0.88mol/L Vs 0.27+0.08mol/L, p<0.05). Varying degrees of correlations were also found between free radicals and electrolytes. Reduced serum MDA levels in TBD suggested a reduction in the levels of free radical injury once treatment was commenced. Therefore serum free radical may be an index of monitoring response to treatment in tuberculosis management.

An astronomy camera for low background applications in the 1. 0 to 2. 5. mu. m spectral region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaki, S.A.; Bailey, G.C.; Hagood, R.W.

1989-02-01

A short wavelength (1.0-2.5 ..mu..m) 128 x 128 focal plane array forms the heart of this low background astronomy camera system. The camera is designed to accept either a 128 x 128 HgCdTe array for the 1-2.5 ..mu..m spectral region or an InSb array for the 3-5 ..mu..m spectral region. A cryogenic folded optical system is utilized to control excess stray light along with a cold eight-position filter wheel for spectral filtering. The camera head and electronics will also accept a 256 x 256 focal plane. Engineering evaluation of the complete system is complete along with two engineering runs atmore » the JPL Table Mountain Observatory. System design, engineering performance, and sample imagery are presented in this paper.« less

Presented by REL Pacific at McREL: A Summary of Cross-Regional Educational Laboratory Studies. Research Digest

ERIC Educational Resources Information Center

Regional Educational Laboratory Pacific, 2013

2013-01-01

REL Pacific at McREL, 1 of 10 Regional Educational Laboratories (RELs) funded by the Institute of Education Sciences (IES), serves educators in American Samoa, the Commonwealth of the Northern Mariana Islands, the Federated States of Micronesia (Chuuk, Kosrae, Pohnpei, and Yap), Guam, Hawai'i, the Republic of the Marshall Islands, and the Republic…

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B

PubMed Central

Santofimia-Castaño, Patricia; Rizzuti, Bruno; Pey, Ángel L.; Soubeyran, Philippe; Vidal, Miguel; Urrutia, Raúl; Iovanna, Juan L.; Neira, José L.

2017-01-01

Intrinsically disordered proteins (IDPs) are ubiquitous in eukaryotes, and they are often associated with diseases in humans. The protein NUPR1 is a multifunctional IDP involved in chromatin remodeling and in the development and progression of pancreatic cancer; however, the details of such functions are unknown. Polycomb proteins are involved in specific transcriptional cascades and gene silencing. One of the proteins of the Polycomb complex is the Ring finger protein 1 (RING1). RING1 is related to aggressive tumor features in multiple cancer types. In this work we characterized the interaction between NUPR1 and the paralogue RING1B in vitro, in silico, and in cellulo. The interaction occurred through the C-terminal region of RING1B (C-RING1B), with an affinity in the low micromolar range (∼10 μM). The binding region of NUPR1, mapped by NMR, was a hydrophobic polypeptide patch at the 30s region of its sequence, as pinpointed by computational results and site-directed mutagenesis at Ala33. The association between C-RING1B and wild-type NUPR1 also occurred in cellulo as tested by protein ligation assays; this interaction is inhibited by trifluoperazine, a drug known to hamper binding of wild-type NUPR1 with other proteins. Furthermore, the Thr68Gln and Ala33Gln/Thr68Gln mutants had a reduction in the binding toward C-RING1B as shown by in vitro, in silico, and in cellulo studies. This is an example of a well-folded partner of NUPR1, because its other interacting proteins are also unfolded. We hypothesize that NUPR1 plays an active role in chromatin remodeling and carcinogenesis, together with Polycomb proteins. PMID:28720707

The Carnegie Observatories

Science.gov Websites

, Receives Prestigious Goldwater Scholarship 2018 Astronomy Lecture Series Are You Rocky or are You Gassy - 4:00pm TBD Colloquium by Dr. Alan Dressler (Carnegie) Astronomy Lecture Series Online You can now

Effects of ischemic preconditioning on PDGF-BB expression in the gerbil hippocampal CA1 region following transient cerebral ischemia

PubMed Central

Lee, Jae-Chul; Kim, Yang Hee; Lee, Tae-Kyeong; Kim, In Hye; Cho, Jeong Hwi; Cho, Geum-Sil; Shin, Bich-Na; Park, Joon Ha; Ahn, Ji Hyeon; Shin, Myoung Cheol; Cho, Jun Hwi; Kang, Il Jun; Won, Moo-Ho; Seo, Jeong Yeol

2017-01-01

Ischemic preconditioning (IPC) is induced by exposure to brief durations of transient ischemia, which results in ischemic tolerance to a subsequent longer or lethal period of ischemia. In the present study, the effects of IPC (2 min of transient cerebral ischemia) were examined on immunoreactivity of platelet-derived growth factor (PDGF)-BB and on neuroprotection in the gerbil hippocampal CA1 region following lethal transient cerebral ischemia (LTCI; 5 min of transient cerebral ischemia). IPC was subjected to a 2-min sublethal ischemia and a LTCI was given 5-min transient ischemia. The animals in all of the groups were given recovery times of 1, 2 and 5 days and change in PDGF-BB immunoreactivity was examined as was the neuronal damage/death in the hippocampus induced by LTCI. LTCI induced a significant loss of pyramidal neurons in the hippocampal CA1 region 5 days after LTCI, and significantly decreased PDGF-BB immunoreactivity in the CA1 pyramidal neurons from day 1 after LTCI. Conversely, IPC effectively protected the CA1 pyramidal neurons from LTCI and increased PDGF-BB immunoreactivity in the CA1 pyramidal neurons post-LTCI. In conclusion, the results demonstrated that LTCI significantly altered PDGF-BB immunoreactivity in pyramidal neurons in the hippocampal CA1 region, whereas IPC increased the immunoreactivity. These findings indicated that PDGF-BB may be associated with IPC-mediated neuroprotection. PMID:28627606

Coexistence of translocation(1,19) and the Philadelphia chromosome in a child's first presentation of chronic myeloid leukemia in blast crisis treated with dasatinib.

PubMed

Eckardt, Mark A; Chang, Vivian Y; Rao, Nagesh P; Federman, Noah

2011-11-01

Chronic myelogenous leukemia (CML) constitutes less than 5% of childhood leukemias. The authors describe a rare case of a 14-year-old boy who presented with CML in blast crisis. Unique to this patient was the evidence of both breakpoint cluster region-c-abl oncogene 1 (BCR-ABL1) fusions as well as an additional unbalanced t(1;19) translocation. This combination has not previously been reported in the same patient. Initial treatment with dasatinib achieved a complete cytogenetic response within 2 months of therapy. This case highlights the heterogeneous presentation of CML in children and rationale for use of dasatinib as a first-line agent for patients with blast crisis.

Regulatory Guidance for Permeable Reactive Barriers Designed to Remediate Chlorinated Solvents

DTIC Science & Technology

1999-12-01

Polyethylene 4ºC 48h Alkalinity 310.1 100mL Polyethylene 4ºC 14d Other TDS 160.2 100 mL Glass, Plastic 4ºC 7d TSS 160.1 100 mL Glass, Plastic 4ºC 7d TOC 415.1...Resource Conservation and Recovery Act SO4 sulfate TBD to be determined TCE trichloroethene, trichloroethylene TDS total dissolved solids TOC total organic...Center ( DFC ) funnel-and-gate system. The aquifer at DFC consists of three lithologic units of decreasing permeability with depth: alluvium, weathered

A novel multi-temporal approach to wet snow retrieval with Sentinel-1 images (Conference Presentation)

NASA Astrophysics Data System (ADS)

Marin, Carlo; Callegari, Mattia; Notarnicola, Claudia

2016-10-01

Snow is one of the most relevant natural water resources present in nature. It stores water in winter and releases it in spring during the melting season. Monitoring snow cover and its variability is thus of great importance for a proactive management of water-resources. Of particular interest is the identification of snowmelt processes, which could significantly support water administration, flood prediction and prevention. In the past years, remote sensing has demonstrated to be an essential tool for providing accurate inputs to hydrological models concerning the spatial and temporal variability of snow. Even though the analysis of snow pack can be conducted in the visible, near-infrared and short-wave infrared spectrum, the presence of clouds during the melting season, which may be pervasive in some parts of the World (e.g., polar regions), renders impossible the regular acquisition of information needed for the operational purposes. Therefore, the use of the microwave sensors, which signal can penetrate the clouds, can be an asset for the detection of snow proprieties. In particular, the SAR images have demonstrated to be effective and robust measurements to identify the wet snow. Among the several methods presented in the literature, the best results in wet snow mapping have been achieved by the bi-temporal change detection approach proposed by Nagler and Rott [1], or its slight improvements presented afterwards (e.g., [2]). Nonetheless, with the introduction of the Sentinel-1 by ESA, which provides free-of-charge SAR images every 6 days over the same geographical area with a resolution of 20m, the scientists have the opportunity to better investigate and improve the state-of-the-art methods for wet snow detection. In this work, we propose a novel method based on a supervised learning approach able to exploit both the experience of the state-of-the-art algorithms and the high multi-temporal information provided by the Sentinel-1 data. In detail, this is done

Specification of unique Pit-1 activity in the hGH locus control region

PubMed Central

Shewchuk, Brian M.; Liebhaber, Stephen A.; Cooke, Nancy E.

2002-01-01

The human GH (hGH) gene cluster is regulated by a remote 5′ locus control region (LCR). HSI, an LCR component located 14.5 kb 5′ to the hGH-N promoter, constitutes the primary determinant of high-level hGH-N activation in pituitary somatotropes. HSI encompasses an array of three binding sites for the pituitary-specific POU homeodomain factor Pit-1. In the present report we demonstrate that all three Pit-1 sites in the HSI array contribute to LCR activity in vivo. Furthermore, these three sites as a unit are fully sufficient for position-independent and somatotrope-restricted hGH-N transgene activation. In contrast, the hGH-N transgene is not activated by Pit-1 sites native to either the hGH-N or rat (r)GH gene promoters. These findings suggest that the structures of the Pit-1 binding sites at HSI specify distinct chromatin-dependent activities essential for LCR-mediated activation of hGH in the developing pituitary. PMID:12189206

Synthetic Fab Fragments that Bind the HIV-1 gp41 Heptad Repeat Regions

PubMed Central

Liu, Yanyun; Regula, Lauren K.; Stewart, Alex; Lai, Jonathan R.

2011-01-01

Recent work has demonstrated that antibody phage display libraries containing restricted diversity in the complementarity determining regions (CDRs) can be used to target a wide variety of antigens with high affinity and specificity. In the most extreme case, antibodies whose combining sites are comprised of only two residues – tyrosine and serine – have been identified against several protein antigens. [F. A. Fellouse, B. Li, D. M. Compaan, A. A. Peden, S. G. Hymowitz, and S. S. Sidhu, J. Mol. Biol., 348 (2005) 1153–1162.] Here, we report the isolation and characterization of antigen-binding fragments (Fabs) from such “minimalist” diversity synthetic antibody libraries that bind the heptad repeat regions of human immunodeficiency virus type 1 (HIV-1) gp41. We show that these Fabs are highly specific for the HIV-1 epitope and comparable in affinity to a single chain variable fragment (scFv) derived from a natural antibody repertoire that targets the same region. Since the heptad repeat regions of HIV-1 gp41 are required for viral entry, these Fabs have potential for use in therapeutic, research, or diagnostic applications. PMID:21925149

Systematic screening for mutations in the 5{prime}-regulatory region of the human dopamine D{sub 1} receptor (DRD1) gene in patients with schizophrenia and bipolar affective disorder

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cichon, S.; Noethen, M.M.; Stoeber, G.

1996-07-26

A possible dysregulation of dopaminergic neurotransmission has been implicated in a variety of neuropsychiatric diseases. In the present study we systematically searched for the presence of mutations in the 5{prime}-flanking region of the dopamine D{sub 1} receptor (DRD1) gene. This region has previously been shown to contain a functional promoter. We investigated 119 unrelated individuals (including 36 schizophrenic patients, 38 bipolar affective patients, and 45 healthy controls) using single-strand conformation analysis (SSCA). Eleven overlapping PCR fragments covered 2,189 bp of DNA sequence. We identified six single base substitutions: -2218T/C, -2102C/A, -2030T/C, -1992G/A, -1251G/C, and -800T/C. None of the mutations wasmore » found to be located in regions which have important influence on the level of transcriptional activity. Allele frequencies were similar in patients and controls, indicating that genetic variation in the 5{prime}-regulatory region of the DRD1 gene is unlikely to play a frequent, major role in the genetic predisposition to either schizophrenia or bipolar affective disorder. 31 refs., 3 tabs.« less

ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sulman, E.P.; Brodeur, G.M.; Ikegaki, N.

1997-03-01

Mouse eck, a member of the EPH gene family, has been mapped to mouse chromosome 4. The syntenic relationship between this chromosome and human chromosome 1 suggests that the human ECK gene maps to the distal short arm of human chromosome 1 (1p). Since this region is frequently deleted or altered in certain tumors of neuroectodermal origin, it is important to define the specific chromosomal localization of the human ECK gene. PCR screening of a rodent-human somatic cell hybrid panel by ECK-specific primers showed that ECK is indeed localized to human chromosome 1. Additional PCR screening of a regional screeningmore » panel for chromosome 1p indicated that ECK is localized to 1p36, distal to FUCA1. Furthermore, fluorescence in situ hybridization analysis with an ECK-specific P1 clone showed that ECK maps proximal to genetic marker D1S228. Taken together, the data suggest that ECK maps to 1p36.1, a region that is frequently deleted in neuroblastoma, melanoma, and other neuroectodermal tumors. 23 refs., 3 figs.« less

47 CFR 1.1204 - Exempt ex parte presentations and proceedings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... presentation is authorized by statute or by the Commission's rules to be made without service, see, e.g., § 1... decision-making process, unless it fits within another exemption not requiring disclosure (e.g., foreign... license; (9) The presentation is made pursuant to an express or implied promise of confidentiality to...

Heart failure in patients presenting with dyspnoea to the emergency department in the Asia Pacific region: an observational study

PubMed Central

Kelly, Anne-Maree; Cullen, Louise; Klim, Sharon; Craig, Simon; Kuan, Win Sen; Jones, Peter; Holdgate, Anna; Lawoko, Charles; Laribi, Said

2017-01-01

Objectives To describe demographic features, assessment, management and outcomes of patients who were diagnosed with heart failure after presenting to an emergency department (ED) with a principal symptom of dyspnoea. Design Planned substudy of the prospective, descriptive cohort study: Asia, Australia and New Zealand Dyspnoea in Emergency Departments (AANZDEM). Setting 46 EDs in Australia, New Zealand, Singapore, Hong Kong and Malaysia collected data over 3 72-hour periods in May, August and October 2014. Participants Patients with an ED diagnosis of heart failure. Outcome measures Outcomes included patient epidemiology, investigations ordered, treatment modalities used and patient outcomes (hospital length of stay (LOS) and mortality). Results 455 (14.9%) of the 3044 patients had an ED diagnosis of heart failure. Median age was 79 years, half were male and 62% arrived via ambulance. 392 (86%) patients were admitted to hospital. ED diagnosis was concordant with hospital discharge diagnosis in 81% of cases. Median hospital LOS was 6 days (IQR 4–9) and in-hospital mortality was 5.1%. Natriuretic peptide levels were ordered in 19%, with lung ultrasound (<1%) and echocardiography (2%) uncommonly performed. Treatment modalities included non-invasive ventilation (12%), diuretics (73%), nitrates (25%), antibiotics (16%), inhaled β-agonists (13%) and corticosteroids (6%). Conclusions In the Asia Pacific region, heart failure is a common diagnosis among patients presenting to the ED with a principal symptom of dyspnoea. Admission rates were high and ED diagnostic accuracy was good. Despite the seemingly suboptimal adherence to investigation and treatment guidelines, patient outcomes were favourable compared with other registries. PMID:28246137

Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1.

PubMed

Murayama, Asako; Kato, Takanobu; Akazawa, Daisuke; Sugiyama, Nao; Date, Tomoko; Masaki, Takahiro; Nakamoto, Shingo; Tanaka, Yasuhito; Mizokami, Masashi; Yokosuka, Osamu; Nomoto, Akio; Wakita, Takaji

2012-02-01

To establish a cell culture system for chimeric hepatitis C virus (HCV) genotype 2b, we prepared a chimeric construct harboring the 5' untranslated region (UTR) to the E2 region of the MA strain (genotype 2b) and the region of p7 to the 3' UTR of the JFH-1 strain (genotype 2a). This chimeric RNA (MA/JFH-1.1) replicated and produced infectious virus in Huh7.5.1 cells. Replacement of the 5' UTR of this chimera with that from JFH-1 (MA/JFH-1.2) enhanced virus production, but infectivity remained low. In a long-term follow-up study, we identified a cell culture-adaptive mutation in the core region (R167G) and found that it enhanced virus assembly. We previously reported that the NS3 helicase (N3H) and the region of NS5B to 3' X (N5BX) of JFH-1 enabled replication of the J6CF strain (genotype 2a), which could not replicate in cells. To reduce JFH-1 content in MA/JFH-1.2, we produced a chimeric viral genome for MA harboring the N3H and N5BX regions of JFH-1, combined with a JFH-1 5' UTR replacement and the R167G mutation (MA/N3H+N5BX-JFH1/R167G). This chimeric RNA replicated efficiently, but virus production was low. After the introduction of four additional cell culture-adaptive mutations, MA/N3H+N5BX-JFH1/5am produced infectious virus efficiently. Using this chimeric virus harboring minimal regions of JFH-1, we analyzed interferon sensitivity and found that this chimeric virus was more sensitive to interferon than JFH-1 and another chimeric virus containing more regions from JFH-1 (MA/JFH-1.2/R167G). In conclusion, we established an HCV genotype 2b cell culture system using a chimeric genome harboring minimal regions of JFH-1. This cell culture system may be useful for characterizing genotype 2b viruses and developing antiviral strategies.

Avionics Interface Data Summaries: A-10A, EF-111A, F-4E, F-4G, F-15A, F- 16A, F-111A, F-111E, F-111F, RF-4C

DTIC Science & Technology

1979-10-01

AIRCRAFT Flight Control ASA-32( ) Flight Director Computer TBD (Same as non -ARN-101 equipped F-4E aircraft) Air Data Computer CPK-92/A24G-34 Attitude...below. A two-inch separation between cable types is arbitrarily set as a minimum design goal. 3.2.6.4.1 Power and Control Circuits. Roucing and channel...plan in accordance with MIL-STD-461A(3) shall be the controlling document for EMIC design . 3.2.7.1 Design Reuire-nents. The generation of and suscepti

Ground/Air Task Oriented Radar (G/ATOR)

DTIC Science & Technology

2015-12-01

Identification (Block 1) (Applicable to Block 4 G/ATOR December 2015 SAR March 18, 2016 06:47:59 UNCLASSIFIED 12 Integrate IFF Mode 5 ( Level 3) and Mode S... Level 3) Integrate IFF Mode 5 ( Level 3) and Mode S ( Level 3) Growth - Block 4. AD/SR shall integrate MK XIIA IFF Mode 5 ( Level 2) capabilities...and Mode S ( level 2) TBD Integrate IFF Mode 5 ( Level 3) and Mode S ( Level 3) Tier 1: Logistics Tier 2: 0perational Contract Support Sustainment

The influence of land cover change in the Asian monsoon region on present-day and mid-Holocene climate

NASA Astrophysics Data System (ADS)

Dallmeyer, A.; Claussen, M.

2011-02-01

Using the general circulation model ECHAM5/JSBACH, we investigate the biogeophysical effect of large-scale afforestation and deforestation in the Asian monsoon domain on present-day and mid-Holocene climate. We demonstrate that the applied land cover change does not only modify the local climate but also change the climate in North Africa and the Middle East via teleconnections. Deforestation in the Asian monsoon domain enhances the rainfall in North Africa. In parts of the Sahara summer precipitation is more than doubled. In contrast, afforestation strongly decreases summer rainfall in the Middle East and even leads to the cessation of the rainfall-activity in some parts of this region. Regarding the local climate, deforestation results in a reduction of precipitation and a cooler climate as grass mostly has a higher albedo than forests. However, in the core region of the Asian monsoon the decrease of evaporative cooling in the monsoon season overcompensates this signal and results in a net warming. Afforestation has mainly the opposite effect, although the pattern of change is less clear. It leads to more precipitation in most parts of the Asian monsoon domain and a warmer climate except for the southern regions where a stronger evaporation decreases near-surface temperatures in the monsoon season. When prescribing mid-Holocene insolation, the pattern of local precipitation change differs. Afforestation particularly increases monsoon rainfall in the region along the Yellow River which was the settlement area of major prehistoric cultures. In this region, the effect of land cover change on precipitation is half as large as the orbitally-induced precipitation change. Thus, our model results reveal that mid- to late-Holocene land cover change could strongly have contributed to the decreasing Asian monsoon precipitation during the Holocene known from reconstructions.

The influence of land cover change in the Asian monsoon region on present-day and mid-Holocene climate

NASA Astrophysics Data System (ADS)

Dallmeyer, A.; Claussen, M.

2011-06-01

Using the general circulation model ECHAM5/JSBACH, we investigate the biogeophysical effect of large-scale afforestation and deforestation in the Asian monsoon domain on present-day and mid-Holocene climate. We demonstrate that the applied land cover change does not only modify the local climate but also change the climate in North Africa and the Middle East via teleconnections. Deforestation in the Asian monsoon domain enhances the rainfall in North Africa. In parts of the Sahara summer precipitation is more than doubled. In contrast, afforestation strongly decreases summer rainfall in the Middle East and even leads to the cessation of the rainfall-activity in some parts of this region. Regarding the local climate, deforestation results in a reduction of precipitation and a cooler climate as grass mostly has a higher albedo than forests. However, in the core region of the Asian monsoon the decrease in evaporative cooling in the monsoon season overcompensates this signal and results in a net warming. Afforestation has mainly the opposite effect, although the pattern of change is less clear. It leads to more precipitation in most parts of the Asian monsoon domain and a warmer climate except for the southern regions where a stronger evaporation decreases near-surface temperatures in the monsoon season. When prescribing mid-Holocene insolation, the pattern of local precipitation change differs. Afforestation particularly increases monsoon rainfall in the region along the Yellow River which was the settlement area of major prehistoric cultures. In this region, the effect of land cover change on precipitation is half as large as the orbitally-induced precipitation change. Thus, our model results reveal that mid- to late-Holocene land cover change could strongly have contributed to the decreasing Asian monsoon precipitation during the Holocene known from reconstructions.

Sports Physical Therapy Section Poster Presentations (Abstracts SPO1-SPO166).

PubMed

2018-01-01

These abstracts are presented here as prepared by the authors. The accuracy and content of each abstract remain the responsibility of the authors. In the identification number above each abstract, SPO designates a Sports Physical Therapy Section poster presentation. J Orthop Sports Phys Ther 2018;48(1):A203-A276. doi:10.2519/jospt.2018.48.1.A203.

Regional Climate Change Hotspots over Africa

NASA Astrophysics Data System (ADS)

Anber, U.

2009-04-01

Regional Climate Change Index (RCCI), is developed based on regional mean precipitation change, mean surface air temperature change, and change in precipitation and temperature interannual variability. The RCCI is a comparative index designed to identify the most responsive regions to climate change, or Hot- Spots. The RCCI is calculated for Seven land regions over North Africa and Arabian region from the latest set of climate change projections by 14 global climates for the A1B, A2 and B1 IPCC emission scenarios. The concept of climate change can be approaches from the viewpoint of vulnerability or from that of climate response. In the former case a Hot-Spot can be defined as a region for which potential climate change impacts on the environment or different activity sectors can be particularly pronounced. In the other case, a Hot-Spot can be defined as a region whose climate is especially responsive to global change. In particular, the characterization of climate change response-based Hot-Spot can provide key information to identify and investigate climate change Hot-Spots based on results from multi-model ensemble of climate change simulations performed by modeling groups from around the world as contributions to the Assessment Report of Intergovernmental Panel on Climate Change (IPCC). A Regional Climate Change Index (RCCI) is defined based on four variables: change in regional mean surface air temperature relative to the global average temperature change ( or Regional Warming Amplification Factor, RWAF ), change in mean regional precipitation ( , of present day value ), change in regional surface air temperature interannual variability ( ,of present day value), change in regional precipitation interannual variability ( , of present day value ). In the definition of the RCCI it is important to include quantities other than mean change because often mean changes are not the only important factors for specific impacts. We thus also include inter annual

Managing Ocean Dumping in EPA Region 1

EPA Pesticide Factsheets

Overview of ocean dumping in New England, US. Includes materials dumped in the Region, ocean dumping permits issues, dredged material testing guidance, ocean disposal site descriptions and information, regional dredging teams and other partnerships.

Color differences among feral pigeons (Columba livia) are not attributable to sequence variation in the coding region of the melanocortin-1 receptor gene (MC1R)

PubMed Central

2013-01-01

Background Genetic variation at the melanocortin-1 receptor (MC1R) gene is correlated with melanin color variation in many birds. Feral pigeons (Columba livia) show two major melanin-based colorations: a red coloration due to pheomelanic pigment and a black coloration due to eumelanic pigment. Furthermore, within each color type, feral pigeons display continuous variation in the amount of melanin pigment present in the feathers, with individuals varying from pure white to a full dark melanic color. Coloration is highly heritable and it has been suggested that it is under natural or sexual selection, or both. Our objective was to investigate whether MC1R allelic variants are associated with plumage color in feral pigeons. Findings We sequenced 888 bp of the coding sequence of MC1R among pigeons varying both in the type, eumelanin or pheomelanin, and the amount of melanin in their feathers. We detected 10 non-synonymous substitutions and 2 synonymous substitution but none of them were associated with a plumage type. It remains possible that non-synonymous substitutions that influence coloration are present in the short MC1R fragment that we did not sequence but this seems unlikely because we analyzed the entire functionally important region of the gene. Conclusions Our results show that color differences among feral pigeons are probably not attributable to amino acid variation at the MC1R locus. Therefore, variation in regulatory regions of MC1R or variation in other genes may be responsible for the color polymorphism of feral pigeons. PMID:23915680

Measurements of energy behaviour of spin-dependent np—observables over 1.2-3.7 GeV energy region Dubna ``Delta-Sigma'' Experiment

NASA Astrophysics Data System (ADS)

Sharov, V. I.; Anischenko, N. G.; Antonenko, V. G.; Averichev, S. A.; Azhgirey, L. S.; Bartenev, V. D.; Bazhanov, N. A.; Belyaev, A. A.; Blinov, N. A.; Borisov, N. S.; Borzakov, S. B.; Borzunov, Yu. T.; Bushuev, Yu. P.; Chernenko, L. P.; Chernykh, E. V.; Chumakov, V. F.; Dolgh, S. A.; Fedorov, A. N.; Fimushkin, V. V.; Finger, M.; Finger, M.; Golovanov, L. B.; Gurevich, G. M.; Guriev, D. K.; Janata, A.; Kirillov, A. D.; Kolomiets, V. G.; Komogorov, E. V.; Kovalenko, A. D.; Kovalev, A. I.; Krasnov, V. A.; Krstonoshich, P.; Kuzmin, E. S.; Kuzmin, N. A.; Ladygin, V. P.; Lazarev, A. B.; Lehar, F.; de Lesquen, A.; Liburg, M. Yu.; Livanov, A. N.; Lukhanin, A. A.; Maniakov, P. K.; Matafonov, V. N.; Matyushevsky, E. A.; Moroz, V. D.; Morozov, A. A.; Neganov, A. B.; Nikolaevsky, G. P.; Nomofilov, A. A.; Panteleev, Tz.; Pillpenko, Yu. K.; Pisarev, I. L.; Plis, Yu. A.; Polunin, Yu. P.; Prokofiev, A. N.; Prytkov, V. Yu.; Rukoyatkin, P. A.; Schedrov, V. A.; Schevelev, O. N.; Shilov, S. N.; Shindin, R. A.; Slunecka, M.; Slunečková, V.; Starikov, A. Yu.; Stoletov, G. D.; Strunov, L. N.; Svetov, A. L.; Usov, Yu. A.; Vasiliev, T.; Volkov, V. I.; Vorobiev, E. I.; Yudin, I. P.; Zaitsev, I. V.; Zhdanov, A. A.; Zhmyrov, V. N.

2005-01-01

New accurate data on the neutron-proton spin-dependent total cross section difference Δ σ L( np) at the neutron beam kinetic energies 1.4, 1.7, 1.9 and 2.0 GeV are presented. A number of physical and methodical results on investigation of an elastic np→pn charge exchange process over a few GeV region are also presented. Measurements were carried out at the Synchrophasotron and Nuclotron of the Veksler and Baldin Laboratory of High Energies of the Joint Institute for Nuclear Research.

Localization of new, microdissection- generated, anonymous markers and of the genes Pcsk1, Dhfr, Ndub13, and Ccnb1 to rat chromosome region 2q1.

PubMed

Quan, X; Laes, J F; Ravoet, M; Van Vooren, P; Szpirer, J; Szpirer, C

2000-01-01

The centromeric region of rat chromosome 2 (2q1) harbors unidentified quantitative trait loci of genes that control tumor growth or development. To improve the mapping of this chromosome region, we microdissected it and generated 10 new microsatellite markers, which we included in the linkage map and/or radiation hybrid map of 2q1, together with other known markers, including four genes: Pcsk1 (protein convertase 1), Dhfr (dihydrofolate reductase), Ndub13 (NADH ubiquinone oxidoreductase subunit b13), and Ccnb1 (cyclin B1). To generate anchor points between the different maps, the gene Ndub13 and the microsatellite markers D2Ulb25 and D2Mit1 were also localized cytogenetically. The radiation map generated in region 2q1 extends its centromeric end of about 150 cR. Copyright 2000 S. Karger AG, Basel

CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_Terra-FM1_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_PFM+FM1_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

Cascaded Ga1-xAlxAs/GaAs solar cell with graded i-region

NASA Astrophysics Data System (ADS)

Mil'shtein, Sam; Halilov, Samed

2018-02-01

In current study we designed p-i-n junction with extended intrinsic layer, where linearly graded Alx Ga1-x As presents variable energy gap so needed for effective harvesting of sun radiation. The design realization involves two regions of compositional structure in the stacking direction. The top AlxGa1-xAs layer of 1 um total thickness has stoichiometric structure x=0.3-0.2d, where depth d runs from 0 to 1 um, topmost 200 nm of which is Be-doped. Bottom AlxGa1-xAs layer of 3 um total thickness has a variable composition of x=0.133-0.033d, d runs from 1 to 4 um, the very bottom of which with 10 nm thickness is Si-doped. On the top surface, there is a 50 nm layer of p+ doped GaAs as a spacer for growing AuGe/Ni anode electrode of 20% surface area, the bottom is coated with AuGe/Ni cathode electrode. The designed cell demonstrates 89% fill factor and 30% conversion efficiency without anti-reflection coating.

Region-based automatic building and forest change detection on Cartosat-1 stereo imagery

NASA Astrophysics Data System (ADS)

Tian, J.; Reinartz, P.; d'Angelo, P.; Ehlers, M.

2013-05-01

In this paper a novel region-based method is proposed for change detection using space borne panchromatic Cartosat-1 stereo imagery. In the first step, Digital Surface Models (DSMs) from two dates are generated by semi-global matching. The geometric lateral resolution of the DSMs is 5 m × 5 m and the height accuracy is in the range of approximately 3 m (RMSE). In the second step, mean-shift segmentation is applied on the orthorectified images of two dates to obtain initial regions. A region intersection following a merging strategy is proposed to get minimum change regions and multi-level change vectors are extracted for these regions. Finally change detection is achieved by combining these features with weighted change vector analysis. The result evaluations demonstrate that the applied DSM generation method is well suited for Cartosat-1 imagery, and the extracted height values can largely improve the change detection accuracy, moreover it is shown that the proposed change detection method can be used robustly for both forest and industrial areas.

Respiratory failure presenting in H1N1 influenza with Legionnaires disease: two case reports

PubMed Central

2011-01-01

Introduction Media sensationalism on the H1N1 outbreak may have influenced decisional processes and clinical diagnosis. Case Presentation We report two cases of patients who presented in 2009 with coexisting H1N1 virus and Legionella infections: a 69-year-old Caucasian man and a 71-year-old Caucasian woman. In our cases all the signs and symptoms, including vomiting, progressive respiratory disease leading to respiratory failure, refractory hypoxemia, leukopenia, lymphopenia, thrombocytopenia, and elevated levels of creatine kinase and hepatic aminotransferases, were consistent with critical illness due to 2009 H1N1 virus infection. Other infectious disorders may mimic H1N1 viral infection especially Legionnaires' disease. Because the swine flu H1N1 pandemic occurred in Autumn in Italy, Legionnaires disease was to be highly suspected since the peak incidence usually occurs in early fall. We do think that our immediate suspicion of Legionella infection based on clinical history and X-ray abnormalities was fundamental for a successful resolution. Conclusion Our two case reports suggest that patients with H1N1 should be screened for Legionella, which is not currently common practice. This is particularly important since the signs and symptoms of both infections are similar. PMID:22018019

The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.

PubMed

Chmielewska, Aldona Ewa; Tang, Ngang Heok; Toda, Takashi

2016-01-01

The establishment of proper kinetochore-microtubule attachments facilitates faithful chromosome segregation. Incorrect attachments activate the spindle assembly checkpoint (SAC), which blocks anaphase onset via recruitment of a cohort of SAC components (Mph1/MPS1, Mad1, Mad2, Mad3/BubR1, Bub1 and Bub3) to kinetochores. KNL1, a component of the outer kinetochore KMN network (KNL1/Mis12 complex/Ndc80 complex), acts as a platform for Bub1 and Bub3 localization upon its phosphorylation by Mph1/MPS1. The Ndc80 protein, a major microtubule-binding site, is critical for MPS1 localization to the kinetochores in mammalian cells. Here we characterized the newly isolated mutant ndc80-AK01 in fission yeast, which contains a single point mutation within the hairpin region. This hairpin connects the preceding calponin-homology domain with the coiled-coil region. ndc80-AK01 was hypersensitive to microtubule depolymerizing reagents with no apparent growth defects without drugs. Subsequent analyses indicated that ndc80-AK01 is defective in SAC signaling, as mutant cells proceeded into lethal cell division in the absence of microtubules. Under mitotic arrest conditions, all SAC components (Ark1/Aurora B, Mph1, Bub1, Bub3, Mad3, Mad2 and Mad1) did not localize to the kinetochore. Further genetic analyses indicated that the Ndc80 hairpin region might act as a platform for the kinetochore recruitment of Mph1, which is one of the most upstream SAC components in the hierarchy. Intriguingly, artificial tethering of Mph1 to the kinetochore fully restored checkpoint signaling in ndc80-AK01 cells, further substantiating the notion that Ndc80 is a kinetochore platform for Mph1. The hairpin region of Ndc80, therefore, plays a critical role in kinetochore recruitment of Mph1.

The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast

PubMed Central

Chmielewska, Aldona Ewa; Tang, Ngang Heok; Toda, Takashi

2016-01-01

ABSTRACT The establishment of proper kinetochore-microtubule attachments facilitates faithful chromosome segregation. Incorrect attachments activate the spindle assembly checkpoint (SAC), which blocks anaphase onset via recruitment of a cohort of SAC components (Mph1/MPS1, Mad1, Mad2, Mad3/BubR1, Bub1 and Bub3) to kinetochores. KNL1, a component of the outer kinetochore KMN network (KNL1/Mis12 complex/Ndc80 complex), acts as a platform for Bub1 and Bub3 localization upon its phosphorylation by Mph1/MPS1. The Ndc80 protein, a major microtubule-binding site, is critical for MPS1 localization to the kinetochores in mammalian cells. Here we characterized the newly isolated mutant ndc80-AK01 in fission yeast, which contains a single point mutation within the hairpin region. This hairpin connects the preceding calponin-homology domain with the coiled-coil region. ndc80-AK01 was hypersensitive to microtubule depolymerizing reagents with no apparent growth defects without drugs. Subsequent analyses indicated that ndc80-AK01 is defective in SAC signaling, as mutant cells proceeded into lethal cell division in the absence of microtubules. Under mitotic arrest conditions, all SAC components (Ark1/Aurora B, Mph1, Bub1, Bub3, Mad3, Mad2 and Mad1) did not localize to the kinetochore. Further genetic analyses indicated that the Ndc80 hairpin region might act as a platform for the kinetochore recruitment of Mph1, which is one of the most upstream SAC components in the hierarchy. Intriguingly, artificial tethering of Mph1 to the kinetochore fully restored checkpoint signaling in ndc80-AK01 cells, further substantiating the notion that Ndc80 is a kinetochore platform for Mph1. The hairpin region of Ndc80, therefore, plays a critical role in kinetochore recruitment of Mph1. PMID:26900649

Space-weather Parameters for 1,000 Active Regions Observed by SDO/HMI

NASA Astrophysics Data System (ADS)

Bobra, M.; Liu, Y.; Hoeksema, J. T.; Sun, X.

2013-12-01

We present statistical studies of several space-weather parameters, derived from observations of the photospheric vector magnetic field by the Helioseismic and Magnetic Imager (HMI) aboard the Solar Dynamics Observatory, for a thousand active regions. Each active region has been observed every twelve minutes during the entirety of its disk passage. Some of these parameters, such as energy density and shear angle, indicate the deviation of the photospheric magnetic field from that of a potential field. Other parameters include flux, helicity, field gradients, polarity inversion line properties, and measures of complexity. We show that some of these parameters are useful for event prediction.

Interaction of the Transcription Start Site Core Region and Transcription Factor YY1 Determine Ascorbate Transporter SVCT2 Exon 1a Promoter Activity

PubMed Central

Qiao, Huan; May, James M.

2012-01-01

Transcription of the ascorbate transporter, SVCT2, is driven by two distinct promoters in exon 1 of the transporter sequence. The exon 1a promoter lacks a classical transcription start site and little is known about regulation of promoter activity in the transcription start site core (TSSC) region. Here we present evidence that the TSSC binds the multifunctional initiator-binding protein YY1. Electrophoresis shift assays using YY1 antibody showed that YY1 is present as one of two major complexes that specifically bind to the TSSC. The other complex contains the transcription factor NF-Y. Mutations in the TSSC that decreased YY1 binding also impaired the exon 1a promoter activity despite the presence of an upstream activating NF-Y/USF complex, suggesting that YY1 is involved in the regulation of the exon 1a transcription. Furthermore, YY1 interaction with NF-Y and/or USF synergistically enhanced the exon 1a promoter activity in transient transfections and co-activator p300 enhanced their synergistic activation. We propose that the TSSC plays a vital role in the exon 1a transcription and that this function is partially carried out by the transcription factor YY1. Moreover, co-activator p300 might be able to synergistically enhance the TSSC function via a “bridge” mechanism with upstream sequences. PMID:22532872

The region of CQQQKPQRRP of PGC-1{alpha} interacts with the DNA-binding complex of FXR/RXR{alpha}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kanaya, Eiko; Jingami, Hisato

2006-04-14

PGC-1{alpha} co-activates transcription by several nuclear receptors. To study the interaction among PGC-1{alpha}, RXR{alpha}/FXR, and DNA, we performed electrophoresis mobility shift assays. The RXR{alpha}/FXR proteins specifically bound to DNA containing the IR-1 sequence in the absence of ligand. When the fusion protein of GST-PGC-1{alpha} was added to the mixture of RXR{alpha}/FXR/DNA, the ligand-influenced retardation of the mobility was observed. The ligand for RXR{alpha} (9-cis-retinoic acid) was necessary for this retardation, whereas, the ligand for FXR, chenodeoxycholic acid, barely had an effect. The results obtained using truncated PGC-1{alpha} proteins suggested that two regions are necessary for PGC-1{alpha} to interact with themore » DNA-binding complex of RXR{alpha}/FXR. One is the region of the second leucine-rich motif, and the other is that of the amino acid sequence CQQQKPQRRP, present between the second and third leucine-rich motifs. The results obtained with the SPQSS mutation for KPQRR suggested that the basic amino acids are important for the interaction.« less

Regional variation in rates of pediatric perforated appendicitis.

PubMed

Sarda, Samir; Short, Heather L; Hockenberry, Jason M; McCarthy, Ian; Raval, Mehul V

2017-09-01

While trends in perforated appendicitis (PA) rates have been studied, regional variability in pediatric admissions for PA remains unknown. A retrospective, cross-sectional analysis of the 2006-2012 Kids' Inpatient Database was conducted to examine variation in PA admission rates by region of the United States and insurance status. PA rates were calculated and reported as per 1000 admissions in accordance with national quality measure specifications. National PA rates per 1000 admissions for 2006, 2009, and 2012 were 313.9, 279.2, and 309.1, respectively. Similarly, all regions demonstrated a statistically significant decrease in PA rates between 2006 and 2009 (p<0.001), where the increase in rates between 2009 and 2012 was only statistically significant in the Midwest [Odds Ratio (OR) 1.07; 95% Confidence Interval (95%CI) 1.03-1.12] and West (OR 1.10; 95% CI 1.07-1.14). The Northeast consistently experienced the lowest PA rates. The odds of PA were highest among uninsured patients (OR 1.35; 95% CI 1.31-1.29). The South had the highest proportion of uninsured children, and these patients had the highest odds of perforation (OR 1.57; 95% CI 1.21-2.02). For children with appendicitis, geographic region and insurance status appear to be associated with perforation upon presentation. Understanding regional variation in pediatric PA rates may inform health policymakers in the constantly evolving insurance coverage landscape. Level III Treatment Study - Retrospective comparative study of appendicitis presentation in children by region of the country. Copyright © 2017 Elsevier Inc. All rights reserved.

Physics of the N=Z and N=Z+1 Nuclei in the A = 80--100 Region

NASA Astrophysics Data System (ADS)

Bucurescu, D.

2007-04-01

A review of the experimental work performed at the GASP array with the purpose of the identification and first spectroscopic measurements of the heaviest even-even N=Z and odd-A N=Z+1 nuclei (mass larger than 80) is made. Systematic experiments in this mass region led to the first study of seven such nuclei: 88Ru, 81Zr, 85Mo, 89Ru, 91Rh, 93Pd, and 95Ag, and extensive data on many other nuclei in their neighborhood. The systematic evolution of the level structures in both even-even and odd-A nuclei, between N approx Z approx 40 and N approx Z approx 47 is briefly presented. The possibility that effects of the neutron-proton pairing have been observed, as well as the type of collectivity observed in this region are discussed.

Superfund Record of Decision (EPA Region 6): Longhorn Army Ammunition Plant, Group 1 Sites, Karnack, TX, January 23, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-10-01

This decision document presents the selected No Further Action alternative for Group 1 Sites, Longhorn Army Ammunition Plant (LHAAP), In Karnack, Texas. The public comment period for the Group 1 Sites No Further Action Proposed Plan ended August 20, 1997. During the public comment period, the Army received four comments. These comments were in regards to future excising of the facility property, PCB`s (no PCB`s found), off-site sampling, and the area`s regional water supply.

Characterization of HIV Type 1 Envelope Sequence Among Viral Isolates Circulating in the Northern Region of Colombia, South America

PubMed Central

Villarreal, José-Luis; Gutiérrez, Jaime; Palacio, Lucy; Peñuela, Martha; Hernández, Robin; Lemay, Guy

2012-01-01

Abstract To characterize human immunodeficiency virus (HIV-1) strains circulating in the Northern region of Colombia in South America, sequences of the viral envelope C2V3C3 region were obtained from patients with different high-risk practices. Close to 60% of the sequences were predicted to belong to macrophage-tropic viruses, according to the positions of acidic amino acids and putative N-linked glycosylation sites. This is in agreement with the fact that most of the patients were recently diagnosed individuals. Phylogenic analysis then allowed assignment of all 35 samples to subtype B viruses. This same subtype was found in previous studies carried out in other Colombian regions. This study thus expands previous analyses with previously missing data from the Northern region of the country. The number and the length of the sequences examined also help to provide a clearer picture of the prevailing situation of the present HIV epidemics in this country. PMID:22482735

Review of the physical oceanography of the Cape Hatteras, North Carolina Region. Volume 1. Literature synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, C.E.; Berger, T.J.; Boicourt, W.C.

The present study is part of a sequence of programs designed to provide the MMS with a basis for evaluating the potential environmental impacts of oil and gas production off of the Cape Hatteras region. The primary objective of this review is to summarize and critique the present state of knowledge of the physical oceanography of the complex region offshore of Cape Hatteras, North Carolina, within the context of understanding the regional circulation and its relation to the fate of any discharges resulting from offshore oil and gas activity. The two other related objectives are to produce an annotated bibliographymore » of the pertinent literature, primarily from 1970 to the present, and to identify relevant oceanographic data sets which can provide a basis for an improved understanding of circulation patterns and physical oceanographic conditions in the study area.« less

Systematic mutational analysis of the intracellular regions of yeast Gap1 permease.

PubMed

Merhi, Ahmad; Gérard, Nicolas; Lauwers, Elsa; Prévost, Martine; André, Bruno

2011-04-19

The yeast general amino acid permease Gap1 is a convenient model for studying the intracellular trafficking of membrane proteins. Present at the plasma membrane when the nitrogen source is poor, it undergoes ubiquitin-dependent endocytosis and degradation upon addition of a good nitrogen source, e.g., ammonium. It comprises 12 transmembrane domains (TM) flanked by cytosol-facing N- and C-terminal tails (NT, CT). The NT of Gap1 contains the acceptor lysines for ubiquitylation and its CT includes a sequence essential to exit from the endoplasmic reticulum (ER). We used alanine-scanning mutagenesis to isolate 64 mutant Gap1 proteins altered in the NT, the CT, or one of the five TM-connecting intracellular loops (L2, -4, -6, -8 and -10). We found 17 mutations (in L2, L8, L10 and CT) impairing Gap1 exit from the ER. Of the 47 mutant proteins reaching the plasma membrane normally, two are unstable and rapidly down-regulated even when the nitrogen source is poor. Six others are totally inactive and another four, altered in a 16-amino-acid sequence in the NT, are resistant to ammonium-induced down-regulation. Finally, a mutation in L6 causes missorting of Gap1 from the secretory pathway to the vacuole. Interestingly, this direct vacuolar sorting seems to be independent of Gap1 ubiquitylation. This study illustrates the importance of multiple intracellular regions of Gap1 in its secretion, transport activity, and down-regulation.

Genetic linkage studies in familial partial epilepsy: Exclusion of the human chromosome regions syntenic to the El-1 mouse locus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopes-Cendes, I.; Mulley, J.C.; Andermann, E.

1994-09-01

Recently, six families with a familial form of partial epilepsy were described. All pedigrees showed autosomal dominant inheritance with incomplete penetrance. Affected individuals present with predominantly nocturnal seizures with frontal lobe semiology. In 1959, a genetic mouse model for partial epilepsy, the El mouse, was reported. In the El mouse, a major seizure susceptibility gene, El-1, segregates in an autosomal dominant fashion and has been localized to a region distal to the centromere of mouse chromosome 9. Comparative genetic maps between man and mouse have been used for prediction of localization of several human disease genes. Because the region ofmore » mouse chromosome 9 that is the most likely to contain the El-1 locus is syntenic to regions on human chromosomes 3q21-p22, 3q21-q23.3, 6q12 and 15q24, we adopted the candidate gene approach as an initial linkage strategy. Twenty-two polymorphic microsatellite markers covering these regions were used for genotyping individuals in the three larger families ascertained, two of which are Australian and one French-Canadian. Negative two-point lod scores were obtained separately for each family. The analysis of all three families combined significantly excludes the candidate regions on chromosomes 3, 6 and 15.« less

The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3.

PubMed

Li, Y; Spellerberg, M B; Stevenson, F K; Capra, J D; Potter, K N

1996-03-01

Essentially all cold agglutinins (CA) with red blood cell I/i specificity isolated from patients with CA disease stemming from lymphoproliferative disorders utilize the VH 4-34 (VH 4-21) gene segment. This near universality of the restricted use of a single gene segment is substantially greater than that demonstrated for other autoantibodies. The monoclonal antibody 9G4 exclusively binds VH 4-34 encoded antibodies and serves as a marker for the VH 4-34 gene segment. Previous studies form our laboratory localized the 9G4 reactive area to framework region 1 (FR1). In the present study, the relative roles of VH FR1, heavy (H) chain complementarity determining region 3 (CDRH 3) and the light (L) chain in I antigen binding were investigated. Mutants containing FR1 sequences from the other VH families, CDRH 3 exchanges, and combinatorial antibodies involving L chain interchanges were produced in the baculovirus system and tested in an I binding assay. The data indicate that FR1 of the VH 4-34 gene segment and the CDRH 3 are essential for the interaction between CA and the I antigen, with the CDRH 3 being fundamental in determining the fine specificity of antigen binding (I versus i). Mutants with substantially altered CDRH 1 and CDRH 2 regions bind I as long as the FR1 is VH 4-34 encoded and the CDRH 3 has a permissive sequence. Light chain swaps indicate that even though antigen binding is predominantly mediated by the H chain, the association with antigen can be abrogated by an incompatible L chain. The necessity for VH 4-34 FR1 explains the almost exclusive use of the VH 4-34 gene segment in cold agglutinins. We hypothesize that, as a general phenomenon, the H chain FR1 of many antibodies may be important in providing the contact required for the close association of antibody with antigen, while the CDRH 3 dictates the fine specificity and strenght of binding.

Supporting Analyses for an Assessment of the Appalachian Regional Commission's Regional Education Service Agencies Program, and Appendices.

ERIC Educational Resources Information Center

Waller, John D.; And Others

This report presents the results of a Rapid Feedback Evaluation focused on 1) policy questions raised by the Appalachian Regional Commission (ARC) concerning its Regional Education Service Agency (RESA) program, and 2) future ARC strategies for evaluating and monitoring RESAs. RESAs are organizations established to provide a range of educational…

Three-Dimensional RNA Structure of the Major HIV-1 Packaging Signal Region

PubMed Central

Stephenson, James D.; Li, Haitao; Kenyon, Julia C.; Symmons, Martyn; Klenerman, Dave; Lever, Andrew M.L.

2013-01-01

Summary HIV-1 genomic RNA has a noncoding 5′ region containing sequential conserved structural motifs that control many parts of the life cycle. Very limited data exist on their three-dimensional (3D) conformation and, hence, how they work structurally. To assemble a working model, we experimentally reassessed secondary structure elements of a 240-nt region and used single-molecule distances, derived from fluorescence resonance energy transfer, between defined locations in these elements as restraints to drive folding of the secondary structure into a 3D model with an estimated resolution below 10 Å. The folded 3D model satisfying the data is consensual with short nuclear-magnetic-resonance-solved regions and reveals previously unpredicted motifs, offering insight into earlier functional assays. It is a 3D representation of this entire region, with implications for RNA dimerization and protein binding during regulatory steps. The structural information of this highly conserved region of the virus has the potential to reveal promising therapeutic targets. PMID:23685210

Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain.

PubMed

Legendre-Guillemin, Valerie; Metzler, Martina; Lemaire, Jean-Francois; Philie, Jacynthe; Gan, Lu; Hayden, Michael R; McPherson, Peter S

2005-02-18

Huntingtin interacting protein 1 (HIP1) is a component of clathrin coats. We previously demonstrated that HIP1 promotes clathrin assembly through its central helical domain, which binds directly to clathrin light chains (CLCs). To better understand the relationship between CLC binding and clathrin assembly we sought to dissect this interaction. Using C-terminal deletion constructs of the HIP1 helical domain, we identified a region between residues 450 and 456 that is required for CLC binding. Within this region, point mutations showed the importance of residues Leu-451, Leu-452, and Arg-453. Mutants that fail to bind CLC are unable to promote clathrin assembly in vitro but still mediate HIP1 homodimerization and heterodimerization with the family member HIP12/HIP1R. Moreover, HIP1 binding to CLC is necessary for HIP1 targeting to clathrin-coated pits and clathrin-coated vesicles. Interestingly, HIP1 binds to a highly conserved region of CLC previously demonstrated to regulate clathrin assembly. These results suggest a role for HIP1/CLC interactions in the regulation of clathrin assembly.

Volume integrals associated with the inhomogeneous Helmholtz equation. Part 1: Ellipsoidal region

NASA Technical Reports Server (NTRS)

Fu, L. S.; Mura, T.

1983-01-01

Problems of wave phenomena in fields of acoustics, electromagnetics and elasticity are often reduced to an integration of the inhomogeneous Helmholtz equation. Results are presented for volume integrals associated with the Helmholtz operator, nabla(2) to alpha(2), for the case of an ellipsoidal region. By using appropriate Taylor series expansions and multinomial theorem, these volume integrals are obtained in series form for regions r 4' and r r', where r and r' are distances from the origin to the point of observation and source, respectively. Derivatives of these integrals are easily evaluated. When the wave number approaches zero, the results reduce directly to the potentials of variable densities.

Localization of a locus (GLC1B) for adult-onset primary open angle glaucoma to the 2cen-q13 region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoilova, D.; Trifan, O.C.; Sarfarazi, M.

1996-08-15

Primary open angle glaucoma (GLC1) is a common ocular disorder with a characteristic degeneration of the optic nerve and visual field defects that is often associated with an elevated intraocular pressure. The severe but rare juvenile-onset type has previously been mapped to 1q21-q31, and its genetic heterogeneity has been established. Herein, we present a new locus (GLC1B) for one form of GLC1 on chromosome 2cen-q13 with a clinical presentation of low to moderate intraocular pressure, onset in late 40s, and a good response to medical treatment. Two-point and haplotype analyses of affected and unaffected meioses in six families provided maximummore » linkage information with D2S417, GATA112EO3, D2S113, D2S373, and D2S274 (lod scores ranging from 3.11 to 6.48) within a region of 8.5 cM that is flanked by D2S2161 and D2S2264. Analysis of affected meioses alone revealed no recombination with an additional two markers (D2S2264 and D2S135) in a region of 11.2 cM that is flanked by D2S2161 and D2S176. Analysis of unaffected meioses identified only one healthy 86-year-old male who has inherited the entire affected haplotype and, hence, is a gene carrier for this condition. Eight additional families with similar and/or different clinical presentation did not show any linkage to this region and, therefore, provided evidence for genetic heterogeneity of adult-onset primary open angle glaucoma. 63 refs., 2 figs., 2 tabs.« less

Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.

PubMed

Xie, Liang; Luo, Chenglong; Zhang, Chengguang; Zhang, Rong; Tang, Jun; Nie, Qinghua; Ma, Li; Hu, Xiaoxiang; Li, Ning; Da, Yang; Zhang, Xiquan

2012-01-01

Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still a challenge. In this genome-wide association study (GWAS), we identified a narrow 1.5 Mb region (173.5-175 Mb) of chicken (Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0-90 d of age measured weekly, biweekly average daily gains (ADG) derived from weekly body weight, and breast muscle weight (BMW), leg muscle weight (LMW) and wing weight (WW) at 90 d of age. Five SNPs in the 1.5 Mb KPNA3-FOXO1A region at GGA1 had the highest significant effects for all growth traits in this study, including a SNP at 8.9 Kb upstream of FOXO1A for BW at 22-48 d and 70 d, a SNP at 1.9 Kb downstream of FOXO1A for WW, a SNP at 20.9 Kb downstream of ENSGALG00000022732 for ADG at 29-42 d, a SNP in INTS6 for BW at 90 d, and a SNP in KPNA3 for BMW and LMW. The 1.5 Mb KPNA3-FOXO1A region contained two microRNA genes that could bind to messenger ribonucleic acid (mRNA) of IGF1, FOXO1A and KPNA3. It was further indicated that the 1.5 Mb GGA1 region had the strongest effects on chicken growth during 22-42 d.

CERES ERBE-like Monthly Regional Averages (ES-9) in HDF ( CER_ES9_Terra-FM1_Edition1-CV)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2006-09-30] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

Catastrophic Drought in the Afro-Asian Monsoon Region During Heinrich Event 1

NASA Astrophysics Data System (ADS)

Stager, J. Curt; Ryves, David B.; Chase, Brian M.; Pausata, Francesco S. R.

2011-03-01

Between 15,000 and 18,000 years ago, large amounts of ice and meltwater entered the North Atlantic during Heinrich stadial 1. This caused substantial regional cooling, but major climatic impacts also occurred in the tropics. Here, we demonstrate that the height of this stadial, about 16,000 to 17,000 years ago (Heinrich event 1), coincided with one of the most extreme and widespread megadroughts of the past 50,000 years or more in the Afro-Asian monsoon region, with potentially serious consequences for Paleolithic cultures. Late Quaternary tropical drying commonly is attributed to southward drift of the intertropical convergence zone, but the broad geographic range of the Heinrich event 1 megadrought suggests that severe, systemic weakening of Afro-Asian rainfall systems also occurred, probably in response to sea surface cooling.

Chapter 1: The Appalachian regional reforestation initiative

Treesearch

Patrick Angel; Vic Davis; Jim Burger; Don Graves; Carl Zipper

2017-01-01

The Appalachian Regional Reforestation Initiative (ARRI) is a cooperative effort by the States of the Appalachian region with the U.S. Department of the Interior's Office of Surface Mining Reclamation and Enforcement (OSMRE) to encourage restoration of high-quality forests on reclaimed coal mines in the eastern United States. The goals of ARRI are to communicate...

Educational Information: Problems and Issues, and Strategies for Resolving Them. Report of a Regional Workshop (Tokyo, Japan, February 1-23, 1983).

ERIC Educational Resources Information Center

National Inst. for Educational Research, Tokyo (Japan).

Proceedings of a Pacific regional workshop to identify developments and problems in educational information services are presented in four chapters. In chapter 1, seminar objectives and participants are listed. Objectives were to review and exchange experiences on the existing information systems and services; to identify crucial issues related to…

Present methods and technology available for intensive management and extent of present use

Treesearch

Gordon F. Weetman

1977-01-01

While there have been major technological developments in regional agriculture and forest harvesting and in intensive forest management in the Southern pine region and the Pacific Northwest, the application and development of intensive forest management has lagged in the Northeast. Some of the characteristics of low, medium and high yield forestry are presented and...

High star formation activity in the central region of a distant cluster at z = 1.46

NASA Astrophysics Data System (ADS)

Hayashi, Masao; Kodama, Tadayuki; Koyama, Yusei; Tanaka, Ichi; Shimasaku, Kazuhiro; Okamura, Sadanori

2010-03-01

We present an unbiased deep [OII] emission survey of a cluster XMMXCS J2215.9-1738 at z = 1.46, the most distant cluster to date with a detection of extended X-ray emission. With wide-field optical and near-infrared cameras (Suprime-Cam and MOIRCS, respectively) on Subaru telescope, we performed deep imaging with a narrow-band filter NB912 (λc = 9139 Å, Δλ = 134 Å) as well as broad-band filters (B,z',J and Ks). From the photometric catalogues, we have identified 44 [OII] emitters in the cluster central region of 6 × 6 arcmin2 down to a dust-free star formation rate (SFR) of 2.6Msolaryr-1 (3σ). Interestingly, it is found that there are many [OII] emitters even in the central high-density region. In fact, the fraction of [OII] emitters to the cluster members as well as their SFRs and equivalent widths stay almost constant with decreasing cluster-centric distance up to the cluster core. Unlike clusters at lower redshifts (z <~ 1) where star formation activity is mostly quenched in their central regions, this higher redshift XMMXCS J2215.9-1738 cluster shows its high star formation activity even at its centre, suggesting that we are beginning to enter the formation epoch of some galaxies in the cluster core eventually. Moreover, we find a deficit of galaxies on the red sequence at magnitudes fainter than ~M* + 0.5 on the colour-magnitude diagram. This break magnitude is brighter than that of lower redshift clusters, and it is likely that we are seeing the formation phase of more massive red galaxies in the cluster core at z ~ 1. These results may indicate inside-out and down-sizing propagation of star formation activity in the course of cluster evolution.

75 FR 26349 - Medicare Program; Payment Policies Under the Physician Fee Schedule and Other Revisions to Part B...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... (AOE): AMA-PCPI Systemic Antimicrobial Therapy-- Avoidance of Inappropriate Use. 100 Colorectal Cancer... Angiotensin Receptor Blocker (ARB) Therapy for Patients with CAD and Diabetes and/or Left Ventricular Systolic... Diabetes Mellitus. 113 Preventive Care and Screening: NCQA Colorectal Cancer Screening. TBD Hypertension...

77 FR 71171 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-29

... DHSS/DHIMS Information Systems User Satisfaction Survey, 0720-TBD. Needs and Uses: The information... (DHIMS) in a repeatable process for continued monitoring of user satisfaction using established... will determine user satisfaction with overall ease of use, access to information needed to perform...

Deterministic control of the emission from light sources in 1D nanoporous photonic crystals (Conference Presentation)

NASA Astrophysics Data System (ADS)

Galisteo-López, Juan F.

2017-02-01

Controlling the emission of a light source demands acting on its local photonic environment via the local density of states (LDOS). Approaches to exert such control on large scale samples, commonly relying on self-assembly methods, usually lack from a precise positioning of the emitter within the material. Alternatively expensive and time consuming techniques can be used to produce samples of small dimensions where a deterministic control on emitter position can be achieved. In this work we present a full solution process approach to fabricate photonic architectures containing nano-emitters which position can be controlled with nanometer precision over squared milimiter regions. By a combination of spin and dip coating we fabricate one-dimensional (1D) nanoporous photonic crystals, which potential in different fields such as photovoltaics or sensing has been previously reported, containing monolayers of luminescent polymeric nanospheres. We demonstrate how, by modifying the position of the emitters within the photonic crystal, their emission properties (photoluminescence intensity and angular distribution) can be deterministically modified. Further, the nano-emitters can be used as a probe to study the LDOS distribution within these systems with a spatial resolution of 25 nm (provided by the probe size) carrying out macroscopic measurements over squared milimiter regions. Routes to enhance light-matter interaction in this kind of systems by combining them with metallic surfaces are finally discussed.

Autoshaping as a function of prior food presentations1

PubMed Central

Downing, Kevin; Neuringer, Allen

1976-01-01

Young chickens were given 1, 10, 100, or 1000 presentations of grain in a hopper. Subsequently, the key was illuminated before each presentation of grain to study autoshaping of the key-peck response. The number of keylight-grain pairings before a bird first pecked the lighted key was found to be a U-shaped function of the number of prior food-only presentations, with pecks occurring significantly sooner after 100 food-only trials than after any of the other values. Two of five chicks at the 100-trial value pecked on the first illumination of the key. Experiment II showed further that when a series of food-only trials (no keylight) preceded keylight-only trials (no food) 30% of the chicks pecked the illuminated key. Experiment III extended the generality of first-trial pecking to pigeons. After preliminary training with food-only, two of five pigeons pecked on the first illumination of a key. The results suggest a close relationship between autoshaping and pseudo-conditioning. PMID:16811961

Intriguing Balancing Selection on the Intron 5 Region of LMBR1 in Human Population

PubMed Central

He, Fang; Wu, Dong-Dong; Kong, Qing-Peng; Zhang, Ya-Ping

2008-01-01

Background The intron 5 of gene LMBR1 is the cis-acting regulatory module for the sonic hedgehog (SHH) gene. Mutation in this non-coding region is associated with preaxial polydactyly, and may play crucial roles in the evolution of limb and skeletal system. Methodology/Principal Findings We sequenced a region of the LMBR1 gene intron 5 in East Asian human population, and found a significant deviation of Tajima's D statistics from neutrality taking human population growth into account. Data from HapMap also demonstrated extended linkage disequilibrium in the region in East Asian and European population, and significantly low degree of genetic differentiation among human populations. Conclusion/Significance We proposed that the intron 5 of LMBR1 was presumably subject to balancing selection during the evolution of modern human. PMID:18698406

Tuberculosis of the head and neck – epidemiological and clinical presentation

PubMed Central

Bruzgielewicz, Antoni; Osuch-Wójcikewicz, Ewa; Niemczyk, Kazimierz; Chmielewski, Rafał

2013-01-01

Introduction The aim of our retrospective study was to review the clinical and epidemiological presentation of head and neck tuberculosis. Material and methods We analyzed the history of 73 patients with head and neck tuberculosis hospitalized in the Department of Otolaryngology, Medical University of Warsaw, between 1983 and 2009. Results We found that 26 (35.6%) patients presented with lymph node tuberculosis, 20 (27.4%) with laryngeal tuberculosis, 10 (13.7%) with oropharyngeal tuberculosis, 9 (12.3%) with salivary gland tuberculosis, 3 (4.1%) with tuberculosis of paranasal sinuses, 3 (4.1%) with aural tuberculosis, and 2 (2.7%) with skin tuberculosis in the head and neck region. Within the group of patients with lymph node tuberculosis in 15 cases there were infected lymph nodes of the 2nd and 3rd cervical region and in 11 infected lymph nodes of the 1st cervical region. In 5 cases of laryngeal tuberculosis there was detected coexistence of cancer. Oropharyngeal tuberculosis in 7 cases was localized in tonsils, where in 1 case coexisting cancer was diagnosed. Chest X-ray was performed in all cases and pulmonary tuberculosis was identified in 26 (35.6%) cases. Conclusions We conclude that tuberculosis still remains a problem and must be taken into consideration in the diagnostic process. The coincidence of tuberculosis and cancer is remarkable in the head and neck region. PMID:25624854

Mouse chromosomal mapping of a murine leukemia virus integration region (Mis-1) first identified in rat thymic leukemia.

PubMed Central

Jolicoeur, P; Villeneuve, L; Rassart, E; Kozak, C

1985-01-01

We have previously identified a region of genomic DNA which constitutes the site of frequent provirus integration in rat thymomas induced by Moloney murine leukemia virus (Lemay and Jolicoeur, Proc. Natl. Acad. Sci. USA 81:38-42, 1984). This genetic locus is now designated Mis-1 (Moloney integration site). Cellular sequences homologous to Mis-1 are present in mouse DNA. Using a series of hamster-mouse somatic cell hybrids, we mapped the Mis-1 locus to mouse chromosome 15. Frequent chromosome 15 aberrations have been described in mouse thymomas. Mis-1 represents a putative new oncogene which might be involved in the initiation or maintenance or both of these neoplasms. Images PMID:4068142

Impacts of heavy groundwater pumping on hydrogeological conditions in Libya: Past and present development and future prognosis on a regional scale

NASA Astrophysics Data System (ADS)

Elgzeli, Yousef M.; Ondovčin, Tomáš; Hrkal, Zbyněk; Krásný, Jiří; Mls, Jiří

2013-06-01

Elgzeli, Y.M., Ondovčin, T., Hrkal, Z., Krasny, J. and Mls, J. 2011. Impacts of heavy groundwater pumping on hydrogeological conditions in Libya: Past and present development and future prognosis on a regional scale. Acta Geologica Polonica, 63 (2), 283-296. Warszawa. Libya, like many other regions with arid climates, suffers from inadequate water resources to cover all the needs of this rapidly developing country. Increasing amounts of water are needed to supply the population, as well as for agricultural irrigation and industrial use. As groundwater is the main water source in the country, it represents a natural resource of the highest economic and social importance. Conceptual and numerical models were implemented on a regional scale to show how the natural situation has changed following heavy groundwater abstraction during the last decades in the northwestern part of the country. The results of the numerical model indicated that the current zones of depression of the piezometric surface could have been caused by smaller withdrawn amounts than previously estimated. The differences in the assessed withdrawn groundwater volumes seem to be quite high and might have a considerable influence on the future possibilities of groundwater use in the study region.

The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region.

PubMed

Pujols, Jordi; Santos, Jaime; Pallarès, Irantzu; Ventura, Salvador

2018-05-06

Response mechanisms to external stress rely on networks of proteins able to activate specific signaling pathways to ensure the maintenance of cell proteostasis. Many of the proteins mediating this kind of response contain intrinsically disordered regions, which lack a defined structure, but still are able to interact with a wide range of clients that modulate the protein function. Some of these interactions are mediated by specific short sequences embedded in the longer disordered regions. Because the physicochemical properties that promote functional and abnormal interactions are similar, it has been shown that, in globular proteins, aggregation-prone and binding regions tend to overlap. It could be that the same principle applies for disordered protein regions. In this context, we show here that a predicted low-complexity interacting region in the disordered C-terminus of the stress response master regulator heat shock factor 1 (Hsf1) protein corresponds to a cryptic amyloid region able to self-assemble into fibrillary structures resembling those found in neurodegenerative disorders.

Atypical Ewing sarcoma breakpoint region 1 fluorescence in-situ hybridization signal patterns in bone and soft tissue tumours: diagnostic experience with 135 cases.

PubMed

Vargas, A Cristina; Selinger, Christina I; Satgunaseelan, Laveniya; Cooper, Wendy A; Gupta, Ruta; Stalley, Paul; Brown, Wendy; Soper, Judy; Schatz, Julie; Boyle, Richard; Thomas, David M; Tattersall, Martin H N; Bhadri, Vivek A; Maclean, Fiona; Bonar, S Fiona; Scolyer, Richard A; Karim, Rooshdiya Z; McCarthy, Stanley W; Mahar, Annabelle; O'Toole, Sandra A

2016-12-01

Recurrent Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangements characterize a select group of bone and soft tissue tumours. In our routine diagnostic practice with fluorescence in-situ hybridization (FISH), we have occasionally observed EWSR1 gene rearrangements in tumours not associated classically with EWSR1 translocations. This study aimed to review our institutional experience of this phenomenon and also to highlight the occurrence of unusual EWSR1 FISH signals (i.e. 5' centromeric region or 3' telomeric region signals) that do not fulfil the published diagnostic criteria for rearrangements. Using an EWSR1 break-apart probe, we performed FISH assays on formalin-fixed paraffin-embedded tissue sections from 135 bone and soft tissue specimens as part of their routine diagnostic work-up. EWSR1 gene rearrangements were identified in 51% of cases, 56% of which also showed an abnormal FISH signal pattern (in addition to classically rearranged signals). However, atypical FISH signals were present in 45% of the non-rearranged cases. In addition, we observed tumours unrelated to those described classically as EWSR1-associated that were technically EWSR1-rearranged in 6% of cases. Borderline levels of rearrangement (affecting 10-30% of lesional cells) were present in an additional 17% of these cases. While our study confirmed that FISH is a sensitive and specific tool in the diagnosis of EWSR1-associated tumours, atypical FISH signals and classical rearrangement in entities other than EWSR1-associated tumours can occur. Therefore, it is essential that the FISH result not be used as an isolated test, but must be evaluated in the context of clinical features, imaging, pathological and immunohistochemical findings. © 2016 John Wiley & Sons Ltd.

Grain size dependent phase stabilities and presence of a monoclinic (Pm) phase in the morphotropic phase boundary region of (1-x)Bi(Mg1/2Ti1/2)O3-xPbTiO3 piezoceramics

NASA Astrophysics Data System (ADS)

Upadhyay, Ashutosh; Singh, Akhilesh Kumar

2015-04-01

Results of the room temperature structural studies on (1-x)Bi(Mg1/2Ti1/2)O3-xPbTiO3 ceramics using Rietveld analysis of the powder x-ray diffraction data in the composition range 0.28 ≤ x ≤ 0.45 are presented. The morphotropic phase boundary region exhibits coexistence of monoclinic (space group Pm) and tetragonal (space group P4 mm) phases in the composition range 0.33 ≤ x ≤ 0.40. The structure is nearly single phase monoclinic (space group Pm) in the composition range 0.28 ≤ x ≤ 0.32. The structure for the compositions with x ≥ 0.45 is found to be predominantly tetragonal with space group P4 mm. Rietveld refinement of the structure rules out the coexistence of rhombohedral and tetragonal phases in the morphotropic phase boundary region reported by earlier authors. The Rietveld structure analysis for the sample x = .35 calcined at various temperatures reveals that phase fraction of the coexisting phases in the morphotropic phase boundary region varies with grain size. The structural parameters of the two coexisting phases also change slightly with changing grain size.

Ischemic preconditioning protects neurons from damage and maintains the immunoreactivity of kynurenic acid in the gerbil hippocampal CA1 region following transient cerebral ischemia

PubMed Central

LEE, JAE-CHUL; TAE, HYUN-JIN; CHO, GEUM-SIL; KIM, IN HYE; AHN, JI HYEON; PARK, JOON HA; CHEN, BAI HUI; CHO, JEONG-HWI; SHIN, BICH NA; CHO, JUN HWI; BAE, EUN JOO; PARK, JINSEU; KIM, YOUNG-MYEONG; CHOI, SOO YOUNG; WON, MOO-HO

2015-01-01

Pyramidal neurons in region I of hippocampus proper (CA1) are particularly vulnerable to excitotoxic processes following transient forebrain ischemia. Kynurenic acid (KYNA) is a small molecule derived from tryptophan when this amino acid is metabolized through the kynurenine pathway. In the present study, we examined the effects of ischemic preconditioning (IPC) on the immunoreactivity and protein levels of KYNA following 5 min of transient forebrain ischemia in gerbils. The animals were randomly assigned to 4 groups (sham-operated group, ischemia-operated group, IPC + sham-operated group and IPC + ischemia-operated group). IPC was induced by subjecting the gerbils to 2 min of ischemia followed by 1 day of recovery. In the ischemia-operated group, we observed a significant loss of pyramidal neurons in the CA1 stratum pyramidale (SP) at 5 days post-ischemia; however, in the IPC + ischemia-operated group, the pyramidal neurons were well protected. KYNA immunoreactivity in the SP of the ischemia-operated group was significantly altered following ischemia-reperfusion and was very low 5 days following ischemia-reperfusion. In the IPC + ischemia-operated group, however, KYNA immunoreactivity was constitutively detected in the SP of the CA1 region after the ischemic insult. We also found that the alteration pattern of the KYNA protein level in the CA1 region following ischemia was generally similar to the immunohistochemical changes observed. In brief, our findings demonstrated that IPC maintained and even increased KYNA immunoreactivity in the SP of the CA1 region following ischemia-reperfusion. The data from the present study thus indicate that the enhancement of KYNA expression by IPC may be necessary for neuronal survival following transient ischemic injury. PMID:25872573

Production of novel recombinant single-domain antibodies against tandem repeat region of MUC1 mucin.

PubMed

Rahbarizadeh, F; Rasaee, M J; Forouzandeh Moghadam, M; Allameh, A A; Sadroddiny, E

2004-06-01

Recently, the existence of "heavy-chain" antibody in Camelidae has been described. However, as yet there is no data on the binding of this type of antibody to peptides. In addition, there was not any report of production of single-domain antibodies in two-humped camels (Camelus bactrianus). In the present study, these questions are addressed. We showed the feasibility of immunizing old world camels, cloning the repertoire of the variable domain of their heavy-chain antibodies, panning and selection, leading to the successful identification of minimum-sized antigen binders. Antigen-specific fragments of the heavy-chain IgGs (V(HH)) are of great interest in biotechnology because they are very stable, highly soluble, and react specifically and with high affinity to the antigens. In this study, we immunized two camels (Camelus dromedarius and Camelus bactrianus) with homogenized cancerous tissues, synthetic peptide, and human milk fat globule membrane (HMFG), and generated two V(HH) libraries displayed on phage particles. Some single-domain antibody fragments have been isolated that specifically recognize the tandem repeat region of MUC1. The camels' single-domain V(HH) harbor the original, intact antigen binding site and reacted specifically and with high affinity to the tandem repeat region of MUC1. Indeed soluble, specific antigen binders and good affinities (in the range of 0.2 x 10(9) M(-1) to 0.6 x 10(9) M(-1)) were identified from these libraries. This is the first example of the isolation of camel anti-peptide V(HH) domains.

Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation.

PubMed

Guo, Haoran; Wei, Wei; Wei, Zhenhong; Liu, Xianjun; Evans, Sean L; Yang, Weiming; Wang, Hong; Guo, Ying; Zhao, Ke; Zhou, Jian-Ying; Yu, Xiao-Fang

2013-01-01

The sterile alpha motif (SAM) and HD domain-containing protein-1 (SAMHD1) inhibits the infection of resting CD4+ T cells and myeloid cells by human and related simian immunodeficiency viruses (HIV and SIV). Vpx inactivates SAMHD1 by promoting its proteasome-dependent degradation through an interaction with CRL4 (DCAF1) E3 ubiquitin ligase and the C-terminal region of SAMHD1. However, the determinants in SAMHD1 that are required for Vpx-mediated degradation have not been well characterized. SAMHD1 contains a classical nuclear localization signal (NLS), and NLS point mutants are cytoplasmic and resistant to Vpx-mediated degradation. Here, we demonstrate that NLS-mutant SAMHD1 K11A can be rescued by wild-type SAMHD1, restoring its nuclear localization; consequently, SAMHD1 K11A became sensitive to Vpx-mediated degradation in the presence of wild-type SAMHD1. Surprisingly, deletion of N-terminal regions of SAMHD1, including the classical NLS, generated mutant SAMHD1 proteins that were again sensitive to Vpx-mediated degradation. Unlike SAMHD1 K11A, these deletion mutants could be detected in the nucleus. Interestingly, NLS-defective SAMHD1 could still bind to karyopherin-β1 and other nuclear proteins. We also determined that the linker region between the SAM and HD domain and the HD domain itself is important for Vpx-mediated degradation but not Vpx interaction. Thus, SAMHD1 contains an additional nuclear targeting mechanism in addition to the classical NLS. Our data indicate that multiple regions in SAMHD1 are critical for Vpx-mediated nuclear degradation and that association with Vpx is not sufficient for Vpx-mediated degradation of SAMHD1. Since the linker region and HD domain may be involved in SAMHD1 multimerization, our results suggest that SAMHD1 multimerization may be required for Vpx-mediation degradation.

Human T-Cell Lymphotropic Virus Types 1 and 2 Seropositivity among Blood Donors at Mbarara Regional Blood Bank, South Western Uganda.

PubMed

Uchenna Tweteise, Patience; Natukunda, Bernard; Bazira, Joel

2016-01-01

Background. The human T-cell lymphotropic virus types 1 and 2 (HTLV 1/2) are retroviruses associated with different pathologies. HTLV-1 causes adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP); HTLV-2 is not clearly associated with a known clinical disease. Both viruses may be transmitted by whole blood transfusion, from mother to child predominantly through breastfeeding, and by sexual contact. Presently, none of the regional blood banks in Uganda perform routine pretransfusion screening for HTLV. The aim of this study was to determine the prevalence of anti-human T-cell lymphotropic virus types 1/2 (HTLV-1/2) antibodies among blood donors at Mbarara Regional Blood Bank in South Western Uganda. A cross-sectional study was conducted between June 2014 and September 2014. Methodology. Consecutive blood samples of 368 blood donors were screened for anti-HTLV-1/2 antibodies using an enzyme linked immunosorbent assay (ELISA). Samples reactive on a first HTLV-1/2 ELISA were further retested in duplicate using the same ELISA. Of the three hundred and sixty-eight blood donors (229 (62.2%) males and 139 (37.8%) females), only two male donors aged 20 and 21 years were HTLV-1/2 seropositive, representing a prevalence of 0.54%. Conclusion. HTLV-1/2 prevalence is low among blood donors at Mbarara Regional Blood Bank. Studies among other categories of people at risk for HTLV 1/2 infection should be carried out.

Lumenal exposed regions of the D1 protein of PSII are long enough to be degraded by the chloroplast Deg1 protease.

PubMed

Knopf, Ronit Rimon; Adam, Zach

2018-03-27

Degradation of the D1 protein of photosystem II (PSII) reaction center is a pre-requisite for the repair cycle from photoinhibition. Two types of thylakoid proteases, FtsH and Deg, have been demonstrated to participate in this process. However, the location of the proteolytic sites of the lumenal Deg1 protease within its internal sphere raised the question whether the lumenal-exposed regions of D1 are indeed long enough to reach these sites. Implanting these regions into the stable GFP rendered it sensitive to the presence of Deg1 in vitro, demonstrating that the flexible regions of D1 that protrude into the lumen can penetrate through the three side-openings of Deg1 and reach its internal proteolytic sites. This mode of action, facilitating cooperation between proteases on both sides of the thylakoid membranes, should be applicable to the degradation of other integral thylakoid membrane proteins as well.

The 2.1-kb inverted repeat DNA sequences flank the mat2,3 silent region in two species of Schizosaccharomyces and are involved in epigenetic silencing in Schizosaccharomyces pombe.

PubMed Central

Singh, Gurjeet; Klar, Amar J S

2002-01-01

The mat2,3 region of the fission yeast Schizosaccharomyces pombe exhibits a phenomenon of transcriptional silencing. This region is flanked by two identical DNA sequence elements, 2.1 kb in length, present in inverted orientation: IRL on the left and IRR on the right of the silent region. The repeats do not encode any ORF. The inverted repeat DNA region is also present in a newly identified related species, which we named S. kambucha. Interestingly, the left and right repeats share perfect identity within a species, but show approximately 2% bases interspecies variation. Deletion of IRL results in variegated expression of markers inserted in the silent region, while deletion of the IRR causes their derepression. When deletions of these repeats were genetically combined with mutations in different trans-acting genes previously shown to cause a partial defect in silencing, only mutations in clr1 and clr3 showed additive defects in silencing with the deletion of IRL. The rate of mat1 switching is also affected by deletion of repeats. The IRL or IRR deletion did not cause significant derepression of the mat2 or mat3 loci. These results implicate repeats for maintaining full repression of the mat2,3 region, for efficient mat1 switching, and further support the notion that multiple pathways cooperate to silence the mat2,3 domain. PMID:12399374

Polymorphisms at the 3' untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats.

PubMed

Iacoboni, Paola A; Hasenauer, Flavia C; Caffaro, M Eugenia; Gaido, Analia; Rossetto, Cristina; Neumann, Roberto D; Salatin, Antonio; Bertoni, Emiliano; Poli, Mario A; Rossetti, Carlos A

2014-08-15

Goats are susceptible to brucellosis and the detection of Brucella-infected animals is carried out by serological tests. In other ruminant species, polymorphisms in microsatellites (Ms) of 3' untranslated region (3'UTR) of the solute carrier family 11 member A1 (SLC11A1) gene were associated with resistance to Brucella abortus infection. Goats present two polymorphic Ms at the 3'UTR end of SLC11A1 gene, called regions A and B. Here, we evaluated if polymorphisms in regions A and/or B are associated with Brucella infection in goats. Serum (for the detection of Brucella-specific antibodies) and hair samples (for DNA isolation and structure analysis of the SLC11A1 gene) were randomly collected from 229 adult native goats from the northwest of Argentina. Serological status was evaluated by buffer plate antigen test (BPAT) complemented by the fluorescent polarization assay (FPA), and the genotype of the 3'UTR of the SLC11A1 gene was determined by capillary electrophoresis and confirmed by sequence analysis. Polymorphisms in regions A and B of the 3'UTR SLC11A1 gene were found statistically significant associated with protection to Brucella infection. Specifically, the association study indicates statistical significance of the allele A15 and B7/B7 genotype with absence of Brucella-specific antibodies (p=0.0003 and 0.0088, respectively). These data open a promising opportunity for limiting goat brucellosis through selective breeding of animals based on genetic markers associated with natural resistance to B. melitensis infection. Copyright © 2014 Elsevier B.V. All rights reserved.

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2010-09-24

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2010 Precision Strike Annual Review Held in Springfield, Virginia on April 20-21, 2010

DTIC Science & Technology

2010-04-21

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Scaling Health and Healthcare: Re-Presenting Thailand's HIV/AIDS Epidemic with World Regional Geography Students

ERIC Educational Resources Information Center

Del Casino Jr, Vincent

2004-01-01

Authors of world regional geography textbooks have recently become more interested in the broader theoretical changes that have emerged in human geography. Relying on feminist and other critical perspectives, concepts such as space, place and scale are being re-imagined in this 'new world regional geography'. This paper intervenes on behalf of a…

Space Science Laboratory publications and presentations, 1 January - 31 December 1991

NASA Technical Reports Server (NTRS)

Moorehead, Tauna W.

1992-01-01

Listed here are significant publications and presentations of the Space Science Laboratory during the period January 1 to December 31, 1991. Entries are categorized according to NASA Reports (arranged by report number), Open Literature, and Presentations (arranged alphabetically by title). Also included is an appendix listing preprints issued by the laboratory during this reporting period.

Seismic data restoration with a fast L1 norm trust region method

NASA Astrophysics Data System (ADS)

Cao, Jingjie; Wang, Yanfei

2014-08-01

Seismic data restoration is a major strategy to provide reliable wavefield when field data dissatisfy the Shannon sampling theorem. Recovery by sparsity-promoting inversion often get sparse solutions of seismic data in a transformed domains, however, most methods for sparsity-promoting inversion are line-searching methods which are efficient but are inclined to obtain local solutions. Using trust region method which can provide globally convergent solutions is a good choice to overcome this shortcoming. A trust region method for sparse inversion has been proposed, however, the efficiency should be improved to suitable for large-scale computation. In this paper, a new L1 norm trust region model is proposed for seismic data restoration and a robust gradient projection method for solving the sub-problem is utilized. Numerical results of synthetic and field data demonstrate that the proposed trust region method can get excellent computation speed and is a viable alternative for large-scale computation.

A Survey on Aflatoxin M1 Content in Sheep and Goat Milk Produced in Sardinia Region, Italy (2005-2013).

PubMed

Virdis, Salvatore; Scarano, Christian; Spanu, Vincenzo; Murittu, Gavino; Spanu, Carlo; Ibba, Ignazio; De Santis, Enrico Pietro Luigi

2014-12-09

In the present work the results of a survey conducted in Sardinia Region on Aflatoxin M 1 (AFM 1 ) contamination in milk of small ruminants from 2005 to 2013 are reported. A total of 517 sheep and 88 goat milk samples from bulk tank, tank trucks and silo tank milk were collected. Analyses were performed by the Regional Farmers Association laboratory using high-performance liquid chromatography following the ISO 14501:1998 standard. None of the sheep milk samples analysed during 2005-2012 showed AFM 1 contamination. In sheep milk samples collected in 2013, 8 out of 172 (4.6%) were contaminated by AFM 1 with a concentration (mean±SD) of 12.59±14.05 ng/L. In one bulk tank milk sample 58.82 ng/L AFM 1 was detected, exceeding the EU limit. In none of goat milk samples analysed from 2010 to 2012 AFM 1 was detected. In 2013, 9 out of 66 goat milk samples (13.6%) showed an AFM 1 concentration of 47.21±19.58 ng/L. Two of these samples exceeded the EU limit, with concentrations of 62.09 and 138.6 ng/L. Higher contamination frequency and concentration rates were detected in bulk tank milk samples collected at farm than in bulk milk truck or silo samples, showing a dilution effect on AFM 1 milk content along small ruminants supply chain. The rate and levels of AFM 1 contamination in sheep and goat milk samples were lower than other countries. However, the small number of milk samples analysed for AFM 1 in Sardinia Region in 2005-2013 give evidence that food business operators check programmes should be improved to ensure an adequate monitoring of AFM 1 contamination in small ruminant dairy chain.

Identification and two-photon imaging of oligodendrocyte in CA1 region of hippocampal slices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou Wei; Ge Wooping; Zeng Shaoqun

2007-01-19

Oligodendrocyte (OL) plays a critical role in myelination and axon maintenance in central nervous system. Recent studies show that OL can also express NMDA receptors in development and pathological situations in white matter. There is still lack of studies about OL properties and function in gray matter of brain. Here we reported that some glial cells in CA1 region of rat hippocampal slices (P15-23) had distinct electrophysiological characteristics from the other glia cells in this region, while they displayed uniform properties with OL from white matter in previous report; therefore, they were considered as OL in hippocampus. By loading dyemore » in recording pipette and imaging with two-photon laser scanning microscopy, we acquired the high spatial resolution, three-dimension images of these special cells in live slices. The OL in hippocampus shows a complex process-bearing shape and the distribution of several processes is parallel to Schaffer fiber in CA1 region. When stimulating Schaffer fiber, OL displays a long duration depolarization mediated by inward rectifier potassium channel. This suggested that the OL in CA1 region could sense the neuronal activity and contribute to potassium clearance.« less

Present-day plate motions

NASA Technical Reports Server (NTRS)

Minster, J. B.; Jordan, T. H.

1977-01-01

A data set comprising 110 spreading rates, 78 transform fault azimuths and 142 earthquake slip vectors was inverted to yield a new instantaneous plate motion model, designated RM2. The mean averaging interval for the relative motion data was reduced to less than 3 My. A detailed comparison of RM2 with angular velocity vectors which best fit the data along individual plate boundaries indicates that RM2 performs close to optimally in most regions, with several notable exceptions. On the other hand, a previous estimate (RM1) failed to satisfy an extensive set of new data collected in the South Atlantic Ocean. It is shown that RM1 incorrectly predicts the plate kinematics in the South Atlantic because the presently available data are inconsistent with the plate geometry assumed in deriving RM1. It is demonstrated that this inconsistency can be remedied by postulating the existence of internal deformation with the Indian plate, although alternate explanations are possible.

Unusual presentation of sunburn.

PubMed

Verma, Gopalkrishna G; Dave, Dhaval; Byrne, Eileen

2008-10-01

We present three cases of sunburn to the head, presenting with oedema of the face in children aged 6, 9 and 13 years. Oedema was predominantly on the forehead and temporal region; a direct effect of gravity was associated with erythema of the scalp. Sunburn healed without any complications.

Interdisciplinary research on the application of ERTS-1 data to the regional land use planning process

NASA Technical Reports Server (NTRS)

Clapp, J. L. (Principal Investigator); Kiefer, R. W.; Mccarthy, M. M.; Niemann, B. J., Jr.

1972-01-01

The author has identified the following significant results. Although the degree to which ERTS-1 imagery can satisfy regional land use planning data needs is not yet known, it appears to offer means by which the data acquisition process can be immeasurably improved. The initial experiences of an interdisciplinary group attempting to formulate ways of analyzing the effectiveness of ERTS-1 imagery as a base for environmental monitoring and the resolution of regional land allocation problems are documented. Application of imagery to the regional planning process consists of utilizing representative geographical regions within the state of Wisconsin. Because of the need to describe and depict regional resource complexity in an interrelatable state, certain resources within the geographical regions have been inventoried and stored in a two-dimensional computer-based map form. Computer oriented processes were developed to provide for the economical storage, analysis, and spatial display of natural and cultural data for regional land use planning purposes. The authors are optimistic that the imagery will provide revelant data for land use decision making at regional levels.

Database for Regional Geology, Phase 1: A Tool for Informing Regional Evaluations of Alternative Geologic Media and Decision Making

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perry, Frank Vinton; Kelley, Richard E.; Birdsell, Suzanne M.

Reported is progress in the following areas: Phase 1 and 2 websites for the regional geology GIS database; terrane maps of crystalline basement rocks; inventory of shale formations in the US; and rock properties and in-situ conditions for shale estimated from sonic velocity measurements.

Bartter Syndrome Type 1 Presenting as Nephrogenic Diabetes Insipidus

PubMed Central

Fabbri, Elena; Pedini, Annalisa; Tedeschi, Silvana; Borsa, Niccolò

2018-01-01

Bartter syndrome (BS) type 1 (OMIM #601678) is a hereditary salt-losing renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, polyuria, recurrent vomiting, and growth retardation. It is caused by loss-of-function mutations of the SLC12A1 gene, encoding the furosemide-sensitive Na-K-Cl cotransporter. Recently, a phenotypic variability has been observed in patients with genetically determined BS, including absence of nephrocalcinosis, hypokalemia, and/or metabolic alkalosis in the first year of life as well as persistent metabolic acidosis mimicking distal renal tubular acidosis. We report the case of a child with a genetically determined diagnosis of Bartter syndrome type 1 who presented with a phenotype of nephrogenic diabetes insipidus, with severe hypernatremia and urinary concentrating defect. In these atypical cases, molecular analysis is mandatory to define the diagnosis, in order to establish the correct clinical and therapeutic management. PMID:29527380

Bartter Syndrome Type 1 Presenting as Nephrogenic Diabetes Insipidus.

PubMed

Vergine, Gianluca; Fabbri, Elena; Pedini, Annalisa; Tedeschi, Silvana; Borsa, Niccolò

2018-01-01

Bartter syndrome (BS) type 1 (OMIM #601678) is a hereditary salt-losing renal tubular disorder characterized by hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, polyuria, recurrent vomiting, and growth retardation. It is caused by loss-of-function mutations of the SLC12A1 gene, encoding the furosemide-sensitive Na-K-Cl cotransporter. Recently, a phenotypic variability has been observed in patients with genetically determined BS, including absence of nephrocalcinosis, hypokalemia, and/or metabolic alkalosis in the first year of life as well as persistent metabolic acidosis mimicking distal renal tubular acidosis. We report the case of a child with a genetically determined diagnosis of Bartter syndrome type 1 who presented with a phenotype of nephrogenic diabetes insipidus, with severe hypernatremia and urinary concentrating defect. In these atypical cases, molecular analysis is mandatory to define the diagnosis, in order to establish the correct clinical and therapeutic management.

Present, future, and novel bioclimates of the San Francisco, California region

USGS Publications Warehouse

Torregrosa, Alicia; Taylor, Maxwell D.; Flint, Lorraine E.; Flint, Alan L.

2013-01-01

Bioclimates are syntheses of climatic variables into biologically relevant categories that facilitate comparative studies of biotic responses to climate conditions. Isobioclimates, unique combinations of bioclimatic indices (continentality, ombrotype, and thermotype), were constructed for northern California coastal ranges based on the Rivas-Martinez worldwide bioclimatic classification system for the end of the 20th century climatology (1971–2000) and end of the 21st century climatology (2070–2099) using two models, Geophysical Fluid Dynamics Laboratory (GFDL) model and the Parallel Climate Model (PCM), under the medium-high A2 emission scenario. The digitally mapped results were used to 1) assess the relative redistribution of isobioclimates and their magnitude of change, 2) quantify the loss of isobioclimates into the future, 3) identify and locate novel isobioclimates projected to appear, and 4) explore compositional change in vegetation types among analog isobioclimate patches. This study used downscaled climate variables to map the isobioclimates at a fine spatial resolution −270 m grid cells. Common to both models of future climate was a large change in thermotype. Changes in ombrotype differed among the two models. The end of 20th century climatology has 83 isobioclimates covering the 63,000 km2 study area. In both future projections 51 of those isobioclimates disappear over 40,000 km2. The ordination of vegetation-bioclimate relationships shows very strong correlation of Rivas-Martinez indices with vegetation distribution and composition. Comparisons of vegetation composition among analog patches suggest that vegetation change will be a local rearrangement of species already in place rather than one requiring long distance dispersal. The digitally mapped results facilitate comparison with other Mediterranean regions. Major remaining challenges include predicting vegetation composition of novel isobioclimates and developing metrics to compare

Present, Future, and Novel Bioclimates of the San Francisco, California Region

PubMed Central

Torregrosa, Alicia; Taylor, Maxwell D.; Flint, Lorraine E.; Flint, Alan L.

2013-01-01

Bioclimates are syntheses of climatic variables into biologically relevant categories that facilitate comparative studies of biotic responses to climate conditions. Isobioclimates, unique combinations of bioclimatic indices (continentality, ombrotype, and thermotype), were constructed for northern California coastal ranges based on the Rivas-Martinez worldwide bioclimatic classification system for the end of the 20th century climatology (1971–2000) and end of the 21st century climatology (2070–2099) using two models, Geophysical Fluid Dynamics Laboratory (GFDL) model and the Parallel Climate Model (PCM), under the medium-high A2 emission scenario. The digitally mapped results were used to 1) assess the relative redistribution of isobioclimates and their magnitude of change, 2) quantify the loss of isobioclimates into the future, 3) identify and locate novel isobioclimates projected to appear, and 4) explore compositional change in vegetation types among analog isobioclimate patches. This study used downscaled climate variables to map the isobioclimates at a fine spatial resolution −270 m grid cells. Common to both models of future climate was a large change in thermotype. Changes in ombrotype differed among the two models. The end of 20th century climatology has 83 isobioclimates covering the 63,000 km2 study area. In both future projections 51 of those isobioclimates disappear over 40,000 km2. The ordination of vegetation-bioclimate relationships shows very strong correlation of Rivas-Martinez indices with vegetation distribution and composition. Comparisons of vegetation composition among analog patches suggest that vegetation change will be a local rearrangement of species already in place rather than one requiring long distance dispersal. The digitally mapped results facilitate comparison with other Mediterranean regions. Major remaining challenges include predicting vegetation composition of novel isobioclimates and developing metrics to compare

MAG4 versus alternative techniques for forecasting active region flare productivity.

PubMed

Falconer, David A; Moore, Ronald L; Barghouty, Abdulnasser F; Khazanov, Igor

2014-05-01

MAG4 is a technique of forecasting an active region's rate of production of major flares in the coming few days from a free magnetic energy proxy. We present a statistical method of measuring the difference in performance between MAG4 and comparable alternative techniques that forecast an active region's major-flare productivity from alternative observed aspects of the active region. We demonstrate the method by measuring the difference in performance between the "Present MAG4" technique and each of three alternative techniques, called "McIntosh Active-Region Class," "Total Magnetic Flux," and "Next MAG4." We do this by using (1) the MAG4 database of magnetograms and major flare histories of sunspot active regions, (2) the NOAA table of the major-flare productivity of each of 60 McIntosh active-region classes of sunspot active regions, and (3) five technique performance metrics (Heidke Skill Score, True Skill Score, Percent Correct, Probability of Detection, and False Alarm Rate) evaluated from 2000 random two-by-two contingency tables obtained from the databases. We find that (1) Present MAG4 far outperforms both McIntosh Active-Region Class and Total Magnetic Flux, (2) Next MAG4 significantly outperforms Present MAG4, (3) the performance of Next MAG4 is insensitive to the forward and backward temporal windows used, in the range of one to a few days, and (4) forecasting from the free-energy proxy in combination with either any broad category of McIntosh active-region classes or any Mount Wilson active-region class gives no significant performance improvement over forecasting from the free-energy proxy alone (Present MAG4). Quantitative comparison of performance of pairs of forecasting techniques Next MAG4 forecasts major flares more accurately than Present MAG4 Present MAG4 forecast outperforms McIntosh AR Class and total magnetic flux.

Local versus regional active stress field in 5900m San Gregorio Magno 1 well (southern Apennines, Italy).

NASA Astrophysics Data System (ADS)

Pierdominici, S.; Montone, P.; Mariucci, M. T.

2009-04-01

The aim of this work is to characterize the local stress field in a peculiar sector of the southern Apennines by analyzing borehole breakouts, fractures and logging data along the San Gregorio Magno 1 deep well, and to compare the achieved stress field with the regional one. The study area is characterized by diffuse low-Magnitude seismicity, although in historical times it has been repeatedly struck by moderate to large earthquakes. We have analyzed in detail the 5900m San Gregorio Magno 1 well drilled in 1996-97 by ENI S.p.A. and located very close (1.3 km away) to the Irpinia Fault. This fault was responsible of the strongest earthquake happened in this area, the 23rd November 1980 M6.9 earthquake that produced the first unequivocal historical surface faulting ever documented in Italy. The mainshock enucleated on a fault 38 km-long with a strike of 308° and 60-70° northeast-dipping, consistent with a NE-SW T-axis and a normal faulting tectonic regime. Borehole breakouts, active faults and focal mechanism solutions have allowed to define the present-day stress along and around the San Gregorio Magno 1 well and other analysis (logging data) to discriminate the presence of fracture zones and/or faults at depth. We have considered data from 1200m to the bottom of San Gregorio Magno 1 well. Our analysis of stress-induced wellbore breakouts shows an inhomogeneous direction of minimum horizontal stress (N359+-31°) orientation along the well. This direction is moderately consistent with the Shmin-trend determined from breakouts in other wells in this region and also with the regional active stress field inferred from active faults and earthquake focal plane solutions (N44 Shmin oriented). For this reason we have computed for each breakout zone the difference between the local trend and the regional one; comparing these breakout rotations with the spikes or changing trend of logs we have identified possible fractures or faults at different depths. We have correlated

Exclusion of linkage between hypokalemic periodic paralysis and a candidate region in 1q31-32 suggests genetic heterogeneity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sillen, A.; Wadelius, C.; Gustabson, K.H.

1994-09-01

Familial hypokalemic periodic paralysis (HOKPP) is an autosomal dominant disease with attacks of paralysis of varying severity. The attacks occur at intervals of days to years in otherwise healthy people combined with hypokalemia during attacks. The paralysis attacks are precipitated by a number of different factors, like carbohydrate-rich meals, cold, exercise and mental stress. Recently linkage for HOKPP was shown for chromosome 1q31-32 and the disease was mapped between D1S413 and D1S249. The gene for the calcium channel alfa1-subunit (CACNL 1A3) maps to this interval and in two families no recombination was found between a polymorphism in the CACNL 1A3more » gene and the disease. This gene is therefore considered to be a candidate for HOKPP. The analysis of a large Danish family excludes linkage to this region and to the CACNL 1A3 gene. In each direction from D1S413, 18.8 cM could be excluded and for D1S249, 14.9 cM. The present study clearly excludes the possibility that the gene causing HOKPP in a large Danish family is located in the region 1q31-32. This result shows that HOKPP is a heterogenous disease, with only one mapped gene so far.« less

Two synthetic Sp1-binding sites functionally substitute for the 21-base-pair repeat region to activate simian virus 40 growth in CV-1 cells.

PubMed Central

Lednicky, J; Folk, W R

1992-01-01

The 21-bp repeat region of simian virus 40 (SV40) activates viral transcription and DNA replication and contains binding sites for many cellular proteins, including Sp1, LSF, ETF, Ap2, Ap4, GT-1B, H16, and p53, and for the SV40 large tumor antigen. We have attempted to reduce the complexity of this region while maintaining its growth-promoting capacity. Deletion of the 21-bp repeat region from the SV40 genome delays the expression of viral early proteins and DNA replication and reduces virus production in CV-1 cells. Replacement of the 21-bp repeat region with two copies of DNA sequence motifs bound with high affinities by Sp1 promotes SV40 growth in CV-1 cells to nearly wild-type levels, but substitution by motifs bound less avidly by Sp1 or bound by other activator proteins does not restore growth. This indicates that Sp1 or a protein with similar sequence specificity is primarily responsible for the function of the 21-bp repeat region. We speculate about how Sp1 activates both SV40 transcription and DNA replication. Images PMID:1328672

Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes.

PubMed

Moulton, Calum D; Costafreda, Sergi G; Horton, Paul; Ismail, Khalida; Fu, Cynthia H Y

2015-12-01

Diabetes is associated with macrovascular and microvascular complications and is a major risk factor for neurological and psychiatric disorders, such as dementia and depression. Type 1 diabetes (T1DM) and type 2 diabetes (T2DM) have distinct etiologies and pathophysiological effects while sharing a common endpoint of persistent hyperglycemia. Neuroimaging studies in T1DM have revealed reductions in numerous regions, including the parahippocampal and occipital regions, while in T2DM there have been numerous reports of hippocampal atrophy. This meta-analysis aimed to identify consistent regional abnormalities in cerebral structures in T1DM and T2DM respectively, and also to examine the impact of potential confounds, including age, depression and vascular risk factors. Neuroimaging studies of both voxel-based morphometry (VBM) data and volumetric data were included. Ten T1DM studies (n = 613 patients) and 23 T2DM studies (n = 1364 patients) fulfilled inclusion criteria. The T1DM meta-analysis revealed reduced bilateral thalamus grey matter density in adults. The T2DM meta-analysis revealed reduced global brain volume and regional atrophy in the hippocampi, basal ganglia, and orbitofrontal and occipital lobes. Moreover, hippocampal atrophy in T2DM was not modified by hypertension, although there were more marked reductions in younger patients relative to healthy controls. In conclusion, T1DM and T2DM demonstrated distinct cerebral effects with generalised and specific target areas of grey matter reduction. Thalamic atrophy in T1DM may be a substrate of associated cognitive deficits. In T2DM, global cerebral atrophy may reflect atherosclerotic factors, while hippocampal atrophy was an independent effect providing a potential common neuropathological etiology for the comorbidity of T2DM with dementia and depression.

A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.

PubMed

Stowell, James A W; Wagstaff, Jane L; Hill, Chris H; Yu, Minmin; McLaughlin, Stephen H; Freund, Stefan M V; Passmore, Lori A

2018-06-15

Mmi1 is an essential RNA-binding protein in the fission yeast Schizosaccharomyces pombe that eliminates meiotic transcripts during normal vegetative growth. Mmi1 contains a YTH domain that binds specific RNA sequences, targeting mRNAs for degradation. The YTH domain of Mmi1 uses a noncanonical RNA-binding surface that includes contacts outside the conserved fold. Here, we report that an N-terminal extension that is proximal to the YTH domain enhances RNA binding. Using X-ray crystallography, NMR, and biophysical methods, we show that this low-complexity region becomes more ordered upon RNA binding. This enhances the affinity of the interaction of the Mmi1 YTH domain with specific RNAs by reducing the dissociation rate of the Mmi1-RNA complex. We propose that the low-complexity region influences RNA binding indirectly by reducing dynamic motions of the RNA-binding groove and stabilizing a conformation of the YTH domain that binds to RNA with high affinity. Taken together, our work reveals how a low-complexity region proximal to a conserved folded domain can adopt an ordered structure to aid nucleic acid binding. © 2018 Stowell et al.

REGIONAL OXIDANT MODEL (ROM) USER'S GUIDE, PART 1: THE ROM PREPROCESSORS

EPA Science Inventory

The Regional Oxidant Model (ROM) determines hourly concentrations and fates of zone and 34 other chemical species over a scale of 1000 km x 1000 km for ozone "episodes" of up to one month's duration. he model structure, based on phenomenological concepts, consists of 3 1/2 layers...

MQ-4C Triton Unmanned Aircraft System (MQ-4C Triton)

DTIC Science & Technology

2015-12-01

will respond to theater level operational or national strategic taskings. MQ-4C Triton December 2015 SAR March 23, 2016 15:26:01 UNCLASSIFIED 6...88% at a mission radius of 2,000 nm Level of Interoperability 1-5 BLOS and LOS from MOB/ FOB (Land Based) MCS BLOS and LOS from MOB/ FOB (Land...MCS UA Mission Radius >=3,000 nm >=3,000 nm >=2,000 nm TBD >=2,000 nm Level Of Interoperability 2 Capability LOS/BLOS multi-ISR payload reception to

77 FR 25707 - Submission for OMB Review; Comment request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

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75 FR 28626 - Subcommittee on Procedures Review, Advisory Board on Radiation and Worker Health (ABRWH...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

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2010-12-27

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48 CFR 1052.232-7003 - Electronic submission of payment requests.

Code of Federal Regulations, 2012 CFR

2012-10-01

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Code of Federal Regulations, 2013 CFR

2013-10-01

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78 FR 31523 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

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77 FR 37001 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

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78 FR 25061 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

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Star formation activity in the southern Galactic H II region G351.63-1.25

NASA Astrophysics Data System (ADS)

Vig, S.; Ghosh, S. K.; Ojha, D. K.; Verma, R. P.; Tamura, M.

2014-06-01

The southern Galactic high-mass star-forming region, G351.63-1.25, is an H II region-molecular cloud complex with a luminosity of ˜2.0 × 105 L⊙, located at a distance of 2.4 kpc from the Sun. In this paper, we focus on the investigation of the associated H II region, embedded cluster and the interstellar medium in the vicinity of G351.63-1.25. We address the identification of exciting source(s) as well as the census of the stellar populations, in an attempt to unfold star formation activity in this region. The ionized gas distribution has been mapped using the Giant Metrewave Radio Telescope, India, at three frequencies: 1280, 610 and 325 MHz. The H II region shows an elongated morphology and the 1280 MHz map comprises six resolved high-density regions encompassed by diffuse emission spanning 1.4 × 1.0 pc2. Based on the measurements of flux densities at multiple radio frequencies, the brightest ultracompact core has electron temperature Te˜7647 {±} 153 K and emission measure, EM˜2.0 {±} 0.8×107 cm-6 pc. The zero-age main-sequence spectral type of the brightest radio core is O7.5. We have carried out near-infrared observations in the JHKs bands using the SIRIUS camera on the 1.4 m Infrared Survey Facility telescope. The near-infrared images reveal the presence of a cluster embedded in nebulous fan-shaped emission. The log-normal slope of the K-band luminosity function of the embedded cluster is found to be ˜0.27 ± 0.03, and the fraction of the near-infrared excess stars is estimated to be 43 per cent. These indicate that the age of the cluster is consistent with ˜1 Myr. Other available data of this region show that the warm (mid-infrared) and cold (millimetre) dust emission peak at different locations indicating progressive stages of star formation process. The champagne flow model from a flat, thin molecular cloud is used to explain the morphology of radio emission with respect to the millimetre cloud and infrared brightness.

Quantifying the Intra-Regional Precipitation Variability in Northwestern China over the Past 1,400 Years

PubMed Central

Lee, Harry F.; Pei, Qing; Zhang, David D.; Choi, Kan P. K.

2015-01-01

There has been a surge of paleo-climatic/environmental studies of Northwestern China (NW China), a region characterized by a diverse assortment of hydro-climatic systems. Their common approach, however, focuses on “deducing regional resemblance” rather than “exploring regional variance.” To date, efforts to produce a quantitative assessment of long-term intra-regional precipitation variability (IRPV) in NW China has been inadequate. In the present study, we base on historical flood/drought records to compile a decadal IRPV index for NW China spanned AD580–1979 and to find its major determinants via wavelet analysis. Results show that our IRPV index captures the footprints of internal hydro-climatic disparity in NW China. In addition, we find distinct ~120–200 year periodicities in the IRPV index over the Little Ice Age, which are attributable to the change of hydro-climatic influence of ocean-atmospheric modes during the period. Also, we offer statistical evidence of El Niño Southern Oscillation (Indo-Pacific warm pool sea surface temperature and China-wide land surface temperature) as the prominent multi-decadal to centennial (centennial to multi-centennial) determinant of the IRPV in NW China. The present study contributes to the quantitative validation of the long-term IRPV in NW China and its driving forces, covering the periods with and without instrumental records. It may help to comprehend the complex hydro-climatic regimes in the region. PMID:26154711

N-terminal regions of Mps1 kinase determine functional bifurcation.

PubMed

Araki, Yasuhiro; Gombos, Linda; Migueleti, Suellen P S; Sivashanmugam, Lavanya; Antony, Claude; Schiebel, Elmar

2010-04-05

Mps1 is a conserved kinase that in budding yeast functions in duplication of the spindle pole body (SPB), spindle checkpoint activation, and kinetochore biorientation. The identity of Mps1 targets and the subdomains that convey specificity remain largely unexplored. Using a novel combination of systematic deletion analysis and chemical biology, we identified two regions within the N terminus of Mps1 that are essential for either SPB duplication or kinetochore biorientation. Suppression analysis of the MPS1 mutants defective in SPB duplication and biochemical enrichment of Mps1 identified the essential SPB components Spc29 and the yeast centrin Cdc31 as Mps1 targets in SPB duplication. Our data suggest that phosphorylation of Spc29 by Mps1 in G1/S recruits the Mps2-Bbp1 complex to the newly formed SPB to facilitate its insertion into the nuclear envelope. Mps1 phosphorylation of Cdc31 at the conserved T110 residue controls substrate binding to Kar1 protein. These findings explain the multiple SPB duplication defects of mps1 mutants on a molecular level.

When chronic conditions become emergencies - a report from regional Queensland.

PubMed

Harriss, Linton R; Thompson, Fintan; Dey, Arindam; Mills, Jane; Watt, Kerrianne; McDermott, Robyn

2016-12-01

To describe chronic conditions and injuries as a proportion of total emergency presentations to a large public hospital in regional Queensland, and to investigate differences in presentation rates associated with Indigenous status. Cross-sectional analysis using Emergency Department Information System data between 1 July 2012 and 30 June 2014. Regional Queensland, Australia. A total of 95 238 emergency presentations were generated by 50 083 local residents living in the 10 statistical local areas (SLAs) immediately around the hospital. Emergency presentations for chronic conditions and injuries identified from discharge ICD-10-AM principal diagnosis. Age-standardised presentation rates were calculated using the Australian 2001 reference population. Approximately half of all presentations were for chronic conditions (20.2%) and injuries (28.8%). Two-thirds of all chronic condition presentations were for mental and behavioural disorders (34.6%) and circulatory diseases (33.2%). Head injuries accounted for the highest proportion of injuries (18.9%). Age-standardised rates for major diagnostic groups were consistently higher for Indigenous residents, whose presentations were lower in mean age (95% CI) by 7.7 (7.3-8.1) years, 23% less likely to be potentially avoidable GP-type presentations [RR (95% CI) = 0.77 (0.75-0.80)], 30% more likely to arrive by ambulance [1.31 (1.28-1.33)] and 11% more likely to require hospital admission [1.11 (1.08-1.13)]. Opportunities exist to enhance current coordinated hospital avoidance and primary health services in regional Queensland targeting common mental and circulatory disorders, especially for Indigenous Australians. © 2016 The Authors. Australian Journal of Rural Health published by John Wiley & Sons Australia, Ltd on behalf of National Rural Health Alliance Inc.

Modelling past, present and future peatland carbon accumulation across the pan-Arctic region

NASA Astrophysics Data System (ADS)

Chaudhary, Nitin; Miller, Paul A.; Smith, Benjamin

2017-09-01

Most northern peatlands developed during the Holocene, sequestering large amounts of carbon in terrestrial ecosystems. However, recent syntheses have highlighted the gaps in our understanding of peatland carbon accumulation. Assessments of the long-term carbon accumulation rate and possible warming-driven changes in these accumulation rates can therefore benefit from process-based modelling studies. We employed an individual-based dynamic global ecosystem model with dynamic peatland and permafrost functionalities and patch-based vegetation dynamics to quantify long-term carbon accumulation rates and to assess the effects of historical and projected climate change on peatland carbon balances across the pan-Arctic region. Our results are broadly consistent with published regional and global carbon accumulation estimates. A majority of modelled peatland sites in Scandinavia, Europe, Russia and central and eastern Canada change from carbon sinks through the Holocene to potential carbon sources in the coming century. In contrast, the carbon sink capacity of modelled sites in Siberia, far eastern Russia, Alaska and western and northern Canada was predicted to increase in the coming century. The greatest changes were evident in eastern Siberia, north-western Canada and in Alaska, where peat production hampered by permafrost and low productivity due the cold climate in these regions in the past was simulated to increase greatly due to warming, a wetter climate and higher CO2 levels by the year 2100. In contrast, our model predicts that sites that are expected to experience reduced precipitation rates and are currently permafrost free will lose more carbon in the future.

Spectrophotometry: Past and Present

NASA Astrophysics Data System (ADS)

Adelman, Saul J.

2009-01-01

I describe the rise of optical region spectrophotometry in the 1960's and 1970's when it achieved a status as a major tool in stellar research through its decline and near demise at present. With absolutely calibrated fluxes and Balmer profiles usually of H-gamma, astronomers used model atmospheres predictions to find both the effective temperatures and surface gravities of many stars. Spectrophotometry as I knew it was photometrically calibrated low dispersion spectroscopy with a typical resolution of order 25 A. A typical data set consists of 10 to 15 values covering most of the optical spectral region. The strengths and shortcomings of the rotating grating scanners are discussed. The accomplishments achieved using spectrophotometric data, which were obtained with instruments using photomultipliers, are reviewed. Extensions to other spectral regions are noted and attempts to use observations from space to calibrate the optical region will be discussed. There are two steps to fully calibrate flux data. The first requires the calibration of the fluxes of one or more standard stars against sources calibrated absolutely in a laboratory. The use of Vega as the primary standard has been both a blessing as it is so bright and a curse especially as modeling it correctly requires treating it as a fast rotating star seen nearly pole-on. At best its calibration has errors of about 1%. The other step is to apply extinction corrections for the Earth's atmosphere and then calibrate the fluxes using the fluxes of standard stars. Now the ASTRA Spectrophotometer promises a revitalization of the use and availability of optical flux data. Its design specifications included solutions to the problems of past optical spectrophotometric instruments.

RETINOBLASTOMA IN INDIA: Clinical Presentation and Outcome in 1,457 Patients (2,074 Eyes).

PubMed

Kaliki, Swathi; Patel, Anamika; Iram, Sadiya; Ramappa, George; Mohamed, Ashik; Palkonda, Vijay A R

2017-11-23

To study the clinical presentation, treatment, and outcome of patients with retinoblastoma (RB) in India. Retrospective study of 1,457 patients with RB (2,074 eyes). The mean age at presentation of RB was 29 months (median, 24 months; range, <1-370 months). There were 812 (56%) men and 645 (44%) women with unilateral presentation of RB in 57% (n = 834) and bilateral in 43% (n = 623). Familial RB was present in 4% (n = 55). The most common presenting complaints included leukocoria (n = 1,100; 75%), proptosis (n = 91; 6%), strabismus (n = 77; 5%), and red eye (n = 68; 5%). Most (n = 1,889; 91%) tumors were intraocular in location, and 185 (n = 185; 9%) had extraocular tumor extension at presentation. The most common modalities of primary treatment-included systemic chemotherapy (n = 1,171; 60%) and enucleation (n = 674; 35%). At a mean follow-up period of 44 months (median, 30 months; range, 3-234 months), 92% (n = 1,206) were alive, and 108 (8%) patients died because of RB. Based on Kaplan-Meier analysis, the survival at 1, 3, 5, and 10 years was 94%, 91%, 90%, and 89%, respectively. The most common presenting signs of RB in Asian Indian population are leukocoria and proptosis. With appropriate treatment, the survival rate is favorable at 92%.

Radiative neutron capture on 242Pu in the resonance region at the CERN n_TOF-EAR1 facility

NASA Astrophysics Data System (ADS)

Lerendegui-Marco, J.; Guerrero, C.; Mendoza, E.; Quesada, J. M.; Eberhardt, K.; Junghans, A. R.; Krtička, M.; Aberle, O.; Andrzejewski, J.; Audouin, L.; Bécares, V.; Bacak, M.; Balibrea, J.; Barbagallo, M.; Barros, S.; Bečvář, F.; Beinrucker, C.; Berthoumieux, E.; Billowes, J.; Bosnar, D.; Brugger, M.; Caamaño, M.; Calviño, F.; Calviani, M.; Cano-Ott, D.; Cardella, R.; Casanovas, A.; Castelluccio, D. M.; Cerutti, F.; Chen, Y. H.; Chiaveri, E.; Colonna, N.; Cortés, G.; Cortés-Giraldo, M. A.; Cosentino, L.; Damone, L. A.; Diakaki, M.; Dietz, M.; Domingo-Pardo, C.; Dressler, R.; Dupont, E.; Durán, I.; Fernández-Domínguez, B.; Ferrari, A.; Ferreira, P.; Finocchiaro, P.; Furman, V.; Göbel, K.; García, A. R.; Gawlik, A.; Glodariu, T.; Gonçalves, I. F.; González-Romero, E.; Goverdovski, A.; Griesmayer, E.; Gunsing, F.; Harada, H.; Heftrich, T.; Heinitz, S.; Heyse, J.; Jenkins, D. G.; Jericha, E.; Käppeler, F.; Kadi, Y.; Katabuchi, T.; Kavrigin, P.; Ketlerov, V.; Khryachkov, V.; Kimura, A.; Kivel, N.; Kokkoris, M.; Leal-Cidoncha, E.; Lederer, C.; Leeb, H.; Lo Meo, S.; Lonsdale, S. J.; Losito, R.; Macina, D.; Marganiec, J.; Martínez, T.; Massimi, C.; Mastinu, P.; Mastromarco, M.; Matteucci, F.; Maugeri, E. A.; Mengoni, A.; Milazzo, P. M.; Mingrone, F.; Mirea, M.; Montesano, S.; Musumarra, A.; Nolte, R.; Oprea, A.; Patronis, N.; Pavlik, A.; Perkowski, J.; Porras, J. I.; Praena, J.; Rajeev, K.; Rauscher, T.; Reifarth, R.; Riego-Perez, A.; Rout, P. C.; Rubbia, C.; Ryan, J. A.; Sabaté-Gilarte, M.; Saxena, A.; Schillebeeckx, P.; Schmidt, S.; Schumann, D.; Sedyshev, P.; Smith, A. G.; Stamatopoulos, A.; Tagliente, G.; Tain, J. L.; Tarifeño-Saldivia, A.; Tassan-Got, L.; Tsinganis, A.; Valenta, S.; Vannini, G.; Variale, V.; Vaz, P.; Ventura, A.; Vlachoudis, V.; Vlastou, R.; Wallner, A.; Warren, S.; Weigand, M.; Weiss, C.; Wolf, C.; Woods, P. J.; Wright, T.; Žugec, P.; n TOF Collaboration

2018-02-01

The spent fuel of current nuclear reactors contains fissile plutonium isotopes that can be combined with uranium to make mixed oxide (MOX) fuel. In this way the Pu from spent fuel is used in a new reactor cycle, contributing to the long-term sustainability of nuclear energy. However, an extensive use of MOX fuels, in particular in fast reactors, requires more accurate capture and fission cross sections for some Pu isotopes. In the case of 242Pu there are sizable discrepancies among the existing capture cross-section measurements included in the evaluations (all from the 1970s) resulting in an uncertainty as high as 35% in the fast energy region. Moreover, postirradiation experiments evaluated with JEFF-3.1 indicate an overestimation of 14% in the capture cross section in the fast neutron energy region. In this context, the Nuclear Energy Agency (NEA) requested an accuracy of 8% in this cross section in the energy region between 500 meV and 500 keV. This paper presents a new time-of-flight capture measurement on 242Pu carried out at n_TOF-EAR1 (CERN), focusing on the analysis and statistical properties of the resonance region, below 4 keV. The 242Pu(n ,γ ) reaction on a sample containing 95(4) mg enriched to 99.959% was measured with an array of four C6D6 detectors and applying the total energy detection technique. The high neutron energy resolution of n_TOF-EAR1 and the good statistics accumulated have allowed us to extend the resonance analysis up to 4 keV, obtaining new individual and average resonance parameters from a capture cross section featuring a systematic uncertainty of 5%, fulfilling the request of the NEA.

Regional agriculture surveys using ERTS-1 data

NASA Technical Reports Server (NTRS)

Draeger, W. C.; Nichols, J. D.; Benson, A. S.; Larrabee, D. G.; Jenkus, W. M.; Hay, C. M.

1974-01-01

The Center for Remote Sensing Research has conducted studies designed to evaluate the potential application of ERTS data in performing agricultural inventories, and to develop efficient methods of data handling and analysis useful in the operational context for performing large area surveys. This work has resulted in the development of an integrated system utilizing both human and computer analysis of ground, aerial, and space imagery, which has been shown to be very efficient for regional crop acreage inventories. The technique involves: (1) the delineation of ERTS images into relatively homogeneous strata by human interpreters, (2) the point-by-point classification of the area within each strata on the basis of crop type using a human/machine interactive digital image processing system; and (3) a multistage sampling procedure for the collection of supporting aerial and ground data used in the adjustment and verification of the classification results.

A Fractal Dimension Survey of Active Region Complexity

NASA Technical Reports Server (NTRS)

McAteer, R. T. James; Gallagher, Peter; Ireland, Jack

2005-01-01

A new approach to quantifying the magnetic complexity of active regions using a fractal dimension measure is presented. This fully-automated approach uses full disc MDI magnetograms of active regions from a large data set (2742 days of the SoHO mission; 9342 active regions) to compare the calculated fractal dimension to both Mount Wilson classification and flare rate. The main Mount Wilson classes exhibit no distinct fractal dimension distribution, suggesting a self-similar nature of all active regions. Solar flare productivity exhibits an increase in both the frequency and GOES X-ray magnitude of flares from regions with higher fractal dimensions. Specifically a lower threshold fractal dimension of 1.2 and 1.25 exists as a necessary, but not sufficient, requirement for an active region to produce M- and X-class flares respectively .