BIM: Enabling Sustainability and Asset Management through Knowledge Management

PubMed Central

2013-01-01

Building Information Modeling (BIM) is the use of virtual building information models to develop building design solutions and design documentation and to analyse construction processes. Recent advances in IT have enabled advanced knowledge management, which in turn facilitates sustainability and improves asset management in the civil construction industry. There are several important qualifiers and some disadvantages of the current suite of technologies. This paper outlines the benefits, enablers, and barriers associated with BIM and makes suggestions about how these issues may be addressed. The paper highlights the advantages of BIM, particularly the increased utility and speed, enhanced fault finding in all construction phases, and enhanced collaborations and visualisation of data. The paper additionally identifies a range of issues concerning the implementation of BIM as follows: IP, liability, risks, and contracts and the authenticity of users. Implementing BIM requires investment in new technology, skills training, and development of new ways of collaboration and Trade Practices concerns. However, when these challenges are overcome, BIM as a new information technology promises a new level of collaborative engineering knowledge management, designed to facilitate sustainability and asset management issues in design, construction, asset management practices, and eventually decommissioning for the civil engineering industry. PMID:24324392

BIM: enabling sustainability and asset management through knowledge management.

PubMed

Kivits, Robbert Anton; Furneaux, Craig

2013-11-10

Building Information Modeling (BIM) is the use of virtual building information models to develop building design solutions and design documentation and to analyse construction processes. Recent advances in IT have enabled advanced knowledge management, which in turn facilitates sustainability and improves asset management in the civil construction industry. There are several important qualifiers and some disadvantages of the current suite of technologies. This paper outlines the benefits, enablers, and barriers associated with BIM and makes suggestions about how these issues may be addressed. The paper highlights the advantages of BIM, particularly the increased utility and speed, enhanced fault finding in all construction phases, and enhanced collaborations and visualisation of data. The paper additionally identifies a range of issues concerning the implementation of BIM as follows: IP, liability, risks, and contracts and the authenticity of users. Implementing BIM requires investment in new technology, skills training, and development of new ways of collaboration and Trade Practices concerns. However, when these challenges are overcome, BIM as a new information technology promises a new level of collaborative engineering knowledge management, designed to facilitate sustainability and asset management issues in design, construction, asset management practices, and eventually decommissioning for the civil engineering industry.

Valid Knowledge: The Economy and the Academy

ERIC Educational Resources Information Center

Williams, Peter John

2007-01-01

The future of Western universities as public institutions is the subject of extensive continuing debate, underpinned by the issue of what constitutes "valid knowledge". Where in the past only propositional knowledge codified by academics was considered valid, in the new economy enabled by information and communications technology, the procedural…

Applications in Educational Assessment: Future Technologies.

ERIC Educational Resources Information Center

Bank Street Coll. of Education, New York, NY. Center for Children and Technology.

The development of improved and alternative methods of educational assessment should take advantage of technologies that enable different aspects of learning, teaching, and student achievement to be part of an improved assessment system. The current understanding of knowledge assessment, new approaches to assessment, and technologies that may…

KDU E-Community Network.

ERIC Educational Resources Information Center

Jonhendro; Ching, Goh Bee; Wahab, Rohazna; Leng, Wang Meei; Aun, Jimmy Tan Lip; Yeoh, Eugene; Hock, Oon; Koo, W. K.

2001-01-01

Describes an education initiative developed by a company in Malaysia, the KDU, to implement a student-centered, teacher-facilitated, educational technology-enabled and knowledge-based learning environment. Explains the KDU e-Community Network that enables passive, interactive, collaborative, and constructivist learning for a variety of…

Investigation of enablers of knowledge transfer in the medical industry.

PubMed

Tuan, Han-Wen

2008-01-01

This paper presents a research model for investigating the relationship between organisational enablers and the Knowledge Transfer (KT) Performance (KTP) in the medical industry. The enablers include leadership, organisational culture, Information Technology (IT) and individual performance measurement, and KTP is determined by individual capability, organisational capability and product/service innovation. This paper chose professional medical personnel as the research subject to determine whether or not these enablers affect KT. The findings show that only leadership directly affects the KTP, with IT also impacting both organisational capability and product/service innovation. The implications of these findings are discussed based on interviews with experts and practitioners.

Knowledge Management for Command and Control

DTIC Science & Technology

2004-06-01

interfaces relies on rich visual and conceptual understanding of what is sketched, rather than the pattern-recognition technologies that most systems use...recognizers) required by other approaches. • The underlying conceptual representations that nuSketch uses enable it to serve as a front end to knowledge...constructing enemy-intent hypotheses via mixed visual and conceptual analogies. II.C. Multi-ViewPoint Clustering Analysis (MVP-CA) technology To

Education and Technology in the 21st Century Experiences of Adult Online Learners Using Web 2.0

ERIC Educational Resources Information Center

Bryant, Wanda L.

2014-01-01

The emergence of a knowledge-based and technology-driven economy has prompted adults to seek additional knowledge and skills that will enable them to participate effectively in society. The rapid growth and popularity of the internet tools such as Web 2.0 tools have revolutionized adult learning. Through the rich support of Web 2.0 tools, adult…

Using social knowledge networking technology to enable meaningful use of electronic health record technology in hospitals and health systems.

PubMed

Rangachari, Pavani

2014-12-01

Despite the federal policy momentum towards "meaningful use" of Electronic Health Records, the healthcare organizational literature remains replete with reports of unintended adverse consequences of implementing Electronic Health Records, including: increased work for clinicians, unfavorable workflow changes, and unexpected changes in communication patterns & practices. In addition to being costly and unsafe, these unintended adverse consequences may pose a formidable barrier to "meaningful use" of Electronic Health Records. Correspondingly, it is essential for hospital administrators to understand and detect the causes of unintended adverse consequences, to ensure successful implementation of Electronic Health Records. The longstanding Technology-in-Practice framework emphasizes the role of human agency in enacting structures of technology use or "technologies-in-practice." Given a set of unintended adverse consequences from health information technology implementation, this framework could help trace them back to specific actions (types of technology-in-practice) and institutional conditions (social structures). On the other hand, the more recent Knowledge-in-Practice framework helps understand how information and communication technologies ( e.g. , social knowledge networking systems) could be implemented alongside existing technology systems, to create new social structures, generate new knowledge-in-practice, and transform technology-in-practice. Therefore, integrating the two literature streams could serve the dual purpose of understanding and overcoming unintended adverse consequences of Electronic Health Record implementation. This paper seeks to: (1) review the theoretical literatures on technology use & implementation, and identify a framework for understanding & overcoming unintended adverse consequences of implementing Electronic Health Records; (2) outline a broad project proposal to test the applicability of the framework in enabling "meaningful use" of Electronic Health Records in a healthcare context; and (3) identify strategies for successful implementation of Electronic Health Records in hospitals & health systems, based on the literature review and application.

Procedural apprenticeship in school science: Constructivist enabling of connoisseurship

NASA Astrophysics Data System (ADS)

Bencze, J. Lawrence

2000-11-01

In many parts of the world, school science, especially at the secondary school level, is a sort of selection and training camp for future scientists and engineers. For most students, their general lack of cultural capital (Apple, 1990) minimizes their opportunities to survive the rapid coverage of large volumes of abstract, decontextualized laws, theories, and inventions so typical of school science. Most graduates and drop-outs become relatively scientifically and technologically illiterate. They either have forgotten or have confused conceptions of scientific and technological knowledge; often view science and technology as relatively certain, unbiased, and benign with respect to effects on society and the environment; and lack resources necessary to effectively judge products and processes of science and technology or, crucially, to create their own explanations for and changes to phenomena. Citizens with illiteracy to this extent may have little control over their own thoughts and actions and be prey to whims of those who control knowledge, its production and dissemination. Curriculum frameworks are required that enable all students to achieve their maximum potential literacy and, as well, to create their own knowledge, to develop in directions unique to their needs, interests, abilities, and perspectives; that is, to become self-actualized. This latter goal can, in part, be achieved through apprenticeship education in schools, such that students acquire a measure of scientific and technological connoisseurship - expertise enabling them to conduct open-ended scientific investigations and invention projects of their design. In collaboration with five teachers of secondary school science, such a framework was, indeed, developed, and field-tested. Through a spiraling, cyclical process involving synchronous reconstruction of conceptual and procedural understandings, evidence suggests students were able to carry out experiments, studies, and tests of their inventions with minimal teacher involvement. Furthermore, they appeared to accommodate more realistic conceptions of scientific and technological work. Moreover, many seemed to have made progress toward intellectual independence; able to judge knowledge claims independent of authorities. It is hoped that with more schools, systems, and teachers enabling development of such connoisseurship, all students will be better served by school science and, as well, the larger society will be more diverse, adaptable, and free.

Challenging the Knowledge-Transfer Orthodoxy: Knowledge Co-construction in Technology-Enhanced Learning for Children with Autism

ERIC Educational Resources Information Center

Guldberg, Karen; Parsons, Sarah; Porayska-Pomsta, Kaska; Keay-Bright, Wendy

2017-01-01

Experimental intervention studies constitute the current dominant research designs in the autism education field. Such designs are based on a "knowledge-transfer" model of evidence-based practice in which research is conducted by researchers, and is then "transferred" to practitioners to enable them to implement evidence-based…

The Stanford how things work project

NASA Technical Reports Server (NTRS)

Fikes, Richard; Gruber, Tom; Iwasaki, Yumi

1994-01-01

We provide an overview of the Stanford How Things Work (HTW) project, an ongoing integrated collection of research activities in the Knowledge Systems Laboratory at Stanford University. The project is developing technology for representing knowledge about engineered devices in a form that enables the knowledge to be used in multiple systems for multiple reasoning tasks and reasoning methods that enable the represented knowledge to be effectively applied to the performance of the core engineering task of simulating and analyzing device behavior. The central new capabilities currently being developed in the project are automated assistance with model formulation and with verification that a design for an electro-mechanical device satisfies its functional specification.

Effects of Multimedia Instructional Strategy for Enhancing Students' Learning and Retention in Mathematics

ERIC Educational Resources Information Center

Kumar, R. Raj; Hema, G.

2017-01-01

Information and Communication Technology (ICT) has infused in every walk of life effecting the technology fields, such as launching satellites, managing businesses across the globe, and also enabling social networking. The technological tools provide students in discovering, classifying, and enhancing the knowledge towards mathematical concepts…

Information Integration for Concurrent Engineering (IICE) IDEF3 Process Description Capture Method Report

DTIC Science & Technology

1995-09-01

vital processes of a business. process, IDEF, method, methodology, modeling, knowledge acquisition, requirements definition, information systems... knowledge resources. Like manpower, materials, and machines, information and knowledge assets are recognized as vital resources that can be leveraged to...integrated enterprise. These technologies are designed to leverage information and knowledge resources as the key enablers for high quality systems

Knowledge and information management for integrated water resource management

USDA-ARS?s Scientific Manuscript database

Watershed information systems that integrate data and analytical tools are critical enabling technologies to support Integrated Water Resource Management (IWRM) by converting data into information, and information into knowledge. Many factors bring people to the table to participate in an IWRM fra...

Technology-Mediation and Tutoring: How Do They Shape Progressive Inquiry Discourse?

ERIC Educational Resources Information Center

Muukkonen, Hanni; Lakkala, Minna; Hakkarainen, Kai

2005-01-01

In higher education, there is a challenge to gain the full benefit of the potentials of learning technology for collaborative knowledge advancement and for scaffolding practices of academic literacy and scientific argumentation. The technology, ideally, would be used to provide support that enables students to deal with more demanding tasks than…

Patent databases and analytical tools for space technology commercialization (Part 2)

NASA Astrophysics Data System (ADS)

Hulsey, William N., III

2002-07-01

A shift in the space industry has occurred that requires technology developers to understand the basics of the intellectual property laws; Global harmonization facilitates this understanding; internet-based tools enable knowledge of these rights and the facts affecting them.

Practices and Strategies of Distributed Knowledge Collaboration

ERIC Educational Resources Information Center

Kudaravalli, Srinivas

2010-01-01

Information Technology is enabling large-scale, distributed collaboration across many different kinds of boundaries. Researchers have used the label new organizational forms to describe such collaborations and suggested that they are better able to meet the demands of flexibility, speed and adaptability that characterize the knowledge economy.…

The importance of knowledge-based technology.

PubMed

Cipriano, Pamela F

2012-01-01

Nurse executives are responsible for a workforce that can provide safer and more efficient care in a complex sociotechnical environment. National quality priorities rely on technologies to provide data collection, share information, and leverage analytic capabilities to interpret findings and inform approaches to care that will achieve better outcomes. As a key steward for quality, the nurse executive exercises leadership to provide the infrastructure to build and manage nursing knowledge and instill accountability for following evidence-based practices. These actions contribute to a learning health system where new knowledge is captured as a by-product of care delivery enabled by knowledge-based electronic systems. The learning health system also relies on rigorous scientific evidence embedded into practice at the point of care. The nurse executive optimizes use of knowledge-based technologies, integrated throughout the organization, that have the capacity to help transform health care.

Self-management support interventions that are clinically linked and technology enabled: can they successfully prevent and treat diabetes?

PubMed

Kaufman, Neal D; Woodley, Paula D Patnoe

2011-05-01

Patients with diabetes need a complex set of services and supports. The challenge of integrating these services into the diabetes regimen can be successfully overcome through self-management support interventions that are clinically linked and technology enabled: self-management support because patients need help mastering the knowledge, attitudes, skills, and behaviors so necessary for good outcomes; interventions because comprehensive theory-based, evidence-proven, long-term, longitudinal interventions work better than direct-to-consumer or nonplanned health promotion approaches; clinically linked because patients are more likely to adopt new behaviors when the approach is in the context of a trusted therapeutic relationship and within an effective medical care system; and technology enabled because capitalizing on the amazing power of information technology leads to the delivery of cost-effective, scalable, engaging solutions that prevent and manage diabetes. © 2011 Diabetes Technology Society.

Riding the Hype Wave: Evaluating new AI Techniques for their Applicability in Earth Science

NASA Astrophysics Data System (ADS)

Ramachandran, R.; Zhang, J.; Maskey, M.; Lee, T. J.

2016-12-01

Every few years a new technology rides the hype wave generated by the computer science community. Converts to this new technology who surface from both the science community and the informatics community promulgate that it can radically improve or even change the existing scientific process. Recent examples of new technology following in the footsteps of "big data" now include deep learning algorithms and knowledge graphs. Deep learning algorithms mimic the human brain and process information through multiple stages of transformation and representation. These algorithms are able to learn complex functions that map pixels directly to outputs without relying on human-crafted features and solve some of the complex classification problems that exist in science. Similarly, knowledge graphs aggregate information around defined topics that enable users to resolve their query without having to navigate and assemble information manually. Knowledge graphs could potentially be used in scientific research to assist in hypothesis formulation, testing, and review. The challenge for the Earth science research community is to evaluate these new technologies by asking the right questions and considering what-if scenarios. What is this new technology enabling/providing that is innovative and different? Can one justify the adoption costs with respect to the research returns? Since nothing comes for free, utilizing a new technology entails adoption costs that may outweigh the benefits. Furthermore, these technologies may require significant computing infrastructure in order to be utilized effectively. Results from two different projects will be presented along with lessons learned from testing these technologies. The first project primarily evaluates deep learning techniques for different applications of image retrieval within Earth science while the second project builds a prototype knowledge graph constructed for Hurricane science.

Supporting Students' Knowledge Integration with Technology-Enhanced Inquiry Curricula

ERIC Educational Resources Information Center

Chiu, Jennifer Lopseen

2010-01-01

Dynamic visualizations of scientific phenomena have the potential to transform how students learn and understand science. Dynamic visualizations enable interaction and experimentation with unobservable atomic-level phenomena. A series of studies clarify the conditions under which embedding dynamic visualizations in technology-enhanced inquiry…

Cryogenic Fluid Management Technologies for Advanced Green Propulsion Systems

NASA Technical Reports Server (NTRS)

Motil, Susan M.; Meyer, Michael L.; Tucker, Stephen P.

2007-01-01

In support of the Exploration Vision for returning to the Moon and beyond, NASA and its partners are developing and testing critical cryogenic fluid propellant technologies that will meet the need for high performance propellants on long-term missions. Reliable knowledge of low-gravity cryogenic fluid management behavior is lacking and yet is critical in the areas of tank thermal and pressure control, fluid acquisition, mass gauging, and fluid transfer. Such knowledge can significantly reduce or even eliminate tank fluid boil-off losses for long term missions, reduce propellant launch mass and required on-orbit margins, and simplify vehicle operations. The Propulsion and Cryogenic Advanced Development (PCAD) Project is performing experimental and analytical evaluation of several areas within Cryogenic Fluid Management (CFM) to enable NASA's Exploration Vision. This paper discusses the status of the PCAD CFM technology focus areas relative to the anticipated CFM requirements to enable execution of the Vision for Space Exploration.

Evaluation of Knowledge Development in a Healthcare Setting

NASA Astrophysics Data System (ADS)

Schaffer, Scott P.

Healthcare organizations worldwide have recently increased efforts to improve performance, quality, and knowledge transfer using information and communication technologies. Evaluation of the effectiveness and quality of such efforts is challenging. A macro and micro-level system evaluation conducted with a 14000 member US hospital administrative services organization examined the appropriateness of a blended face-to-face and technology-enabled performance improvement and knowledge development system. Furthermore, a successful team or microsystem in a high performing hospital was studied in-depth. Several types of data methods including interview, observation, and questionnaire were used to address evaluation questions within a knowledge development framework created for the study. Results of this preliminary study focus on how this organization attempted to organize clinical improvement efforts around quality and performance improvement processes supported by networked technologies.

An Ontology for Learning Services on the Shop Floor

ERIC Educational Resources Information Center

Ullrich, Carsten

2016-01-01

An ontology expresses a common understanding of a domain that serves as a basis of communication between people or systems, and enables knowledge sharing, reuse of domain knowledge, reasoning and thus problem solving. In Technology-Enhanced Learning, especially in Intelligent Tutoring Systems and Adaptive Learning Environments, ontologies serve as…

Educational Benefits of Multimedia Skills Training

ERIC Educational Resources Information Center

Wang, Tsung juang

2010-01-01

The use of multimedia technologies in education has enabled teachers to simulate final outcomes and assist students in applying knowledge learned from textbooks, thereby compensating for the deficiency of traditional teaching methods. It is important to examine how effective these technologies are in practical use. This study developed online…

Outcasts on the Inside: Academics Reinventing Themselves Online

ERIC Educational Resources Information Center

Costa, Cristina

2015-01-01

Recent developments in digital scholarship point out that academic practices supported by technologies may not only be transformed through the obvious process of digitization, but also renovated through distributed knowledge networks that digital technologies enable, and the practices of openness that such networks develop. Yet, this apparent…

Enabling the Differently-Abled

ERIC Educational Resources Information Center

Pal, Sonali

2009-01-01

It is perhaps unfortunate that enabling technologies do not come with an "ability warning", as they generally require the user to already have acquired a certain level of IT skills, in a similar way that online courses require users to have a certain level of prior IT knowledge. Accessing a computer and making the most of e-learning…

Developing Guidelines for Evaluating the Adaptation of Accessible Web-Based Learning Materials

ERIC Educational Resources Information Center

Radovan, Marko; Perdih, Mojca

2016-01-01

E-learning is a rapidly developing form of education. One of the key characteristics of e-learning is flexibility, which enables easier access to knowledge for everyone. Information and communications technology (ICT), which is e-learning's main component, enables alternative means of accessing the web-based learning materials that comprise the…

Better-Than-Visual Technologies for Next Generation Air Transportation System Terminal Maneuvering Area Operations

NASA Technical Reports Server (NTRS)

Prinzel, Lawrence J., III; Bailey, Randall E.; Shelton, Kevin J.; Jones, Denise R.; Kramer, Lynda J.; Arthur, Jarvis J., III; Williams, Steve P.; Barmore, Bryan E.; Ellis, Kyle E.; Rehfeld, Sherri A.

2011-01-01

A consortium of industry, academia and government agencies are devising new concepts for future U.S. aviation operations under the Next Generation Air Transportation System (NextGen). Many key capabilities are being identified to enable NextGen, including the concept of Equivalent Visual Operations (EVO) replicating the capacity and safety of today's visual flight rules (VFR) in all-weather conditions. NASA is striving to develop the technologies and knowledge to enable EVO and to extend EVO towards a Better-Than-Visual (BTV) operational concept. The BTV operational concept uses an electronic means to provide sufficient visual references of the external world and other required flight references on flight deck displays that enable VFR-like operational tempos and maintain and improve the safety of VFR while using VFR-like procedures in all-weather conditions. NASA Langley Research Center (LaRC) research on technologies to enable the concept of BTV is described.

Towards G2G: Systems of Technology Database Systems

NASA Technical Reports Server (NTRS)

Maluf, David A.; Bell, David

2005-01-01

We present an approach and methodology for developing Government-to-Government (G2G) Systems of Technology Database Systems. G2G will deliver technologies for distributed and remote integration of technology data for internal use in analysis and planning as well as for external communications. G2G enables NASA managers, engineers, operational teams and information systems to "compose" technology roadmaps and plans by selecting, combining, extending, specializing and modifying components of technology database systems. G2G will interoperate information and knowledge that is distributed across organizational entities involved that is ideal for NASA future Exploration Enterprise. Key contributions of the G2G system will include the creation of an integrated approach to sustain effective management of technology investments that supports the ability of various technology database systems to be independently managed. The integration technology will comply with emerging open standards. Applications can thus be customized for local needs while enabling an integrated management of technology approach that serves the global needs of NASA. The G2G capabilities will use NASA s breakthrough in database "composition" and integration technology, will use and advance emerging open standards, and will use commercial information technologies to enable effective System of Technology Database systems.

Embodying Computational Thinking: Initial Design of an Emerging Technological Learning Tool

ERIC Educational Resources Information Center

Daily, Shaundra B.; Leonard, Alison E.; Jörg, Sophie; Babu, Sabarish; Gundersen, Kara; Parmar, Dhaval

2015-01-01

This emerging technology report describes virtual environment interactions an approach for blending movement and computer programming as an embodied way to support girls in building computational thinking skills. The authors seek to understand how body syntonicity might enable young learners to bootstrap their intuitive knowledge in order to…

Domain Visualization Using VxInsight[R] for Science and Technology Management.

ERIC Educational Resources Information Center

Boyack, Kevin W.; Wylie, Brian N.; Davidson, George S.

2002-01-01

Presents the application of a knowledge visualization tool, VxInsight[R], to enable domain analysis for science and technology management. Uses data mining from sources of bibliographic information to define subsets of relevant information and discusses citation mapping, text mapping, and journal mapping. (Author/LRW)

Leadership for a Technology-Rich Educational Environment.

ERIC Educational Resources Information Center

Riedl, Richard; Smith, Tracy; Ware, Anita; Wark, Alan; Yount, Peter

This paper emphasizes the importance of exploring the attitudes, skills, and knowledge that will enable individuals in educational leadership positions to function effectively and to provide support to create and maintain technology-rich educational systems. The discussion is guided by the following five elements, the understanding of which are…

Technology Project Learning versus Lab Experimentation

ERIC Educational Resources Information Center

Waks, S.; Sabag, N.

2004-01-01

The Project-Based Learning (PBL) approach enables the student to construct knowledge in his/her own way. Piaget, the founder of constructivism, saw the development of intelligence as a process involving the relationship between brain maturity and individual experience. The technology PBL (TPBL) approach confronts the student with a personal…

Adaptive Social Learning Based on Crowdsourcing

ERIC Educational Resources Information Center

Karataev, Evgeny; Zadorozhny, Vladimir

2017-01-01

Many techniques have been developed to enhance learning experience with computer technology. A particularly great influence of technology on learning came with the emergence of the web and adaptive educational hypermedia systems. While the web enables users to interact and collaborate with each other to create, organize, and share knowledge via…

Incorporating Multiple Technologies into Teacher Education: A Case of Developing Preservice Teachers' Understandings in Teaching Statistics with Technology

ERIC Educational Resources Information Center

Lovett, Jennifer N.; Lee, Hollylynne S.

2017-01-01

The purpose of this paper is to present a multitechnology-enabled lesson used with secondary preservice mathematics teachers to develop their technological pedagogical statistical knowledge. This lesson engages preservice teachers in a statistics lesson aimed at developing their reasoning about the measurement units of data using TinkerPlots and…

[Web-based support system for medical device maintenance].

PubMed

Zhao, Jinhai; Hou, Wensheng; Chen, Haiyan; Tang, Wei; Wang, Yihui

2015-01-01

A Web-based technology system was put forward aiming at the actual problems of the long maintenance cycle and the difficulties of the maintenance and repairing of medical equipments. Based on analysis of platform system structure and function, using the key technologies such as search engine, BBS, knowledge base and etc, a platform for medical equipment service technician to use by online or offline was designed. The platform provides users with knowledge services and interactive services, enabling users to get a more ideal solution.

Intellectual Property: What Do Teachers and Students Know?

ERIC Educational Resources Information Center

Starkey, Louise; Corbett, Susan; Bondy, Ann; Davidson, Susan

2010-01-01

As society changes from an industrial to a knowledge era increasing importance and value is being placed on intellectual property rights. Technology teachers need to have pedagogical content knowledge of intellectual property if they are to incorporate it into their learning programmes to enable students to consider how to respect others'…

Controlled Environments Enable Adaptive Management in Aquatic Ecosystems Under Altered Environments

NASA Technical Reports Server (NTRS)

Bubenheim, David L.

2016-01-01

Ecosystems worldwide are impacted by altered environment conditions resulting from climate, drought, and land use changes. Gaps in the science knowledge base regarding plant community response to these novel and rapid changes limit both science understanding and management of ecosystems. We describe how CE Technologies have enabled the rapid supply of gap-filling science, development of ecosystem simulation models, and remote sensing assessment tools to provide science-informed, adaptive management methods in the impacted aquatic ecosystem of the California Sacramento-San Joaquin River Delta. The Delta is the hub for California's water, supplying Southern California agriculture and urban communities as well as the San Francisco Bay area. The changes in environmental conditions including temperature, light, and water quality and associated expansion of invasive aquatic plants negatively impact water distribution and ecology of the San Francisco Bay/Delta complex. CE technologies define changes in resource use efficiencies, photosynthetic productivity, evapotranspiration, phenology, reproductive strategies, and spectral reflectance modifications in native and invasive species in response to altered conditions. We will discuss how the CE technologies play an enabling role in filling knowledge gaps regarding plant response to altered environments, parameterization and validation of ecosystem models, development of satellite-based, remote sensing tools, and operational management strategies.

An Empirical Study of Lecturers' Appropriation of Social Technologies for Higher Education

ERIC Educational Resources Information Center

Hamid, Suraya; Waycott, Jenny; Kurnia, Sherah; Chang, Shanton

2014-01-01

The use of Online Social Networking (OSN) educational activities has become commonplace in today's higher education. OSN enables lecturers and students to generate and share content, interact, and collaborate in the knowledge construction process. The pedagogical benefits of social technologies have been widely discussed. However, less is known…

Developing Computer Programming Concepts and Skills via Technology-Enriched Language-Art Projects: A Case Study

ERIC Educational Resources Information Center

Lee, Young-Jin

2010-01-01

Teaching computer programming to young children has been considered difficult because of its abstract and complex nature. The objectives of this study are (1) to investigate whether an innovative educational technology tool called Scratch could enable young children to learn abstract knowledge of computer programming while creating multimedia…

The Administrator's Role: Strategies for Fostering Staff Development

ERIC Educational Resources Information Center

Wizer, David R.; McPherson, Sarah J.

2005-01-01

In 1999, funding from a federal technology innovation challenge grant and the state of Maryland enabled the creation of the Maryland Technology Academy (MTA). The MTA is a collaboration of Johns Hopkins University, Towson University, and the Maryland State Department of Education formed with the goal of developing a network of knowledgeable and…

Supporting Student Research with Semantic Technologies and Digital Archives

ERIC Educational Resources Information Center

Martinez-Garcia, Agustina; Corti, Louise

2012-01-01

This article discusses how the idea of higher education students as producers of knowledge rather than consumers can be operationalised by means of student research projects, in which processes of research archiving and analysis are enabled through the use of semantic technologies. It discusses how existing digital repository frameworks can be…

Students and Teachers' Perceptions into the Viability of Mobile Technology Implementation to Support Language Learning for First Year Business Students in a Middle Eastern University

ERIC Educational Resources Information Center

Tayan, Bilal M.

2017-01-01

Advancements in technology have enabled us to learn, adapt and exploit our skills and knowledge in new ways. Appreciating the potential of technology may yet give growth and enrich the process of language education, particularly through a student-centred mobile learning environment. Consequently, a constructivist approach to learning can create…

Semantic Web meets Integrative Biology: a survey.

PubMed

Chen, Huajun; Yu, Tong; Chen, Jake Y

2013-01-01

Integrative Biology (IB) uses experimental or computational quantitative technologies to characterize biological systems at the molecular, cellular, tissue and population levels. IB typically involves the integration of the data, knowledge and capabilities across disciplinary boundaries in order to solve complex problems. We identify a series of bioinformatics problems posed by interdisciplinary integration: (i) data integration that interconnects structured data across related biomedical domains; (ii) ontology integration that brings jargons, terminologies and taxonomies from various disciplines into a unified network of ontologies; (iii) knowledge integration that integrates disparate knowledge elements from multiple sources; (iv) service integration that build applications out of services provided by different vendors. We argue that IB can benefit significantly from the integration solutions enabled by Semantic Web (SW) technologies. The SW enables scientists to share content beyond the boundaries of applications and websites, resulting into a web of data that is meaningful and understandable to any computers. In this review, we provide insight into how SW technologies can be used to build open, standardized and interoperable solutions for interdisciplinary integration on a global basis. We present a rich set of case studies in system biology, integrative neuroscience, bio-pharmaceutics and translational medicine, to highlight the technical features and benefits of SW applications in IB.

Designing Collaborative E-Learning Environments Based upon Semantic Wiki: From Design Models to Application Scenarios

ERIC Educational Resources Information Center

Li, Yanyan; Dong, Mingkai; Huang, Ronghuai

2011-01-01

The knowledge society requires life-long learning and flexible learning environment that enables fast, just-in-time and relevant learning, aiding the development of communities of knowledge, linking learners and practitioners with experts. Based upon semantic wiki, a combination of wiki and Semantic Web technology, this paper designs and develops…

Flight Deck Technologies to Enable NextGen Low Visibility Surface Operations

NASA Technical Reports Server (NTRS)

Prinzel, Lawrence (Lance) J., III; Arthur, Jarvis (Trey) J.; Kramer, Lynda J.; Norman, Robert M.; Bailey, Randall E.; Jones, Denise R.; Karwac, Jerry R., Jr.; Shelton, Kevin J.; Ellis, Kyle K. E.

2013-01-01

Many key capabilities are being identified to enable Next Generation Air Transportation System (NextGen), including the concept of Equivalent Visual Operations (EVO) . replicating the capacity and safety of today.s visual flight rules (VFR) in all-weather conditions. NASA is striving to develop the technologies and knowledge to enable EVO and to extend EVO towards a Better-Than-Visual operational concept. This operational concept envisions an .equivalent visual. paradigm where an electronic means provides sufficient visual references of the external world and other required flight references on flight deck displays that enable Visual Flight Rules (VFR)-like operational tempos while maintaining and improving safety of VFR while using VFR-like procedures in all-weather conditions. The Langley Research Center (LaRC) has recently completed preliminary research on flight deck technologies for low visibility surface operations. The work assessed the potential of enhanced vision and airport moving map displays to achieve equivalent levels of safety and performance to existing low visibility operational requirements. The work has the potential to better enable NextGen by perhaps providing an operational credit for conducting safe low visibility surface operations by use of the flight deck technologies.

Using key performance indicators as knowledge-management tools at a regional health-care authority level.

PubMed

Berler, Alexander; Pavlopoulos, Sotiris; Koutsouris, Dimitris

2005-06-01

The advantages of the introduction of information and communication technologies in the complex health-care sector are already well-known and well-stated in the past. It is, nevertheless, paradoxical that although the medical community has embraced with satisfaction most of the technological discoveries allowing the improvement in patient care, this has not happened when talking about health-care informatics. Taking the above issue of concern, our work proposes an information model for knowledge management (KM) based upon the use of key performance indicators (KPIs) in health-care systems. Based upon the use of the balanced scorecard (BSC) framework (Kaplan/Norton) and quality assurance techniques in health care (Donabedian), this paper is proposing a patient journey centered approach that drives information flow at all levels of the day-to-day process of delivering effective and managed care, toward information assessment and knowledge discovery. In order to persuade health-care decision-makers to assess the added value of KM tools, those should be used to propose new performance measurement and performance management techniques at all levels of a health-care system. The proposed KPIs are forming a complete set of metrics that enable the performance management of a regional health-care system. In addition, the performance framework established is technically applied by the use of state-of-the-art KM tools such as data warehouses and business intelligence information systems. In that sense, the proposed infrastructure is, technologically speaking, an important KM tool that enables knowledge sharing amongst various health-care stakeholders and between different health-care groups. The use of BSC is an enabling framework toward a KM strategy in health care.

Strategies and challenges for nursery production: Perspectives on where we're going and where we've been

Treesearch

Diane L. Haase

2010-01-01

During the past century, seedling production has changed in accordance with technology and new knowledge. Many strategies have been developed to address challenges associated with pests, environmental conditions, and customer demands. Although the underlying concepts for growing seedlings have remained relatively constant, technological advances have enabled nurseries...

Science Students' Use of the Internet for Learning in Higher Institutions in Osun State, Nigeria

ERIC Educational Resources Information Center

Oyelekan, Oloyede Solomon; Akinpelu, Gabriel Akinyemi; Daramola, Florence Olutunu

2015-01-01

The Internet is one technology that has impacted tremendously on the sociological fabric of man. In the field of education, it serves as a library of knowledge from where virtually all information could be obtained. Knowledge of how well higher institution students use the Internet for learning may enable their lecturers take appropriate decisions…

Framework for Building Collaborative Research Environment

DOE PAGES

Devarakonda, Ranjeet; Palanisamy, Giriprakash; San Gil, Inigo

2014-10-25

Wide range of expertise and technologies are the key to solving some global problems. Semantic web technology can revolutionize the nature of how scientific knowledge is produced and shared. The semantic web is all about enabling machine-machine readability instead of a routine human-human interaction. Carefully structured data, as in machine readable data is the key to enabling these interactions. Drupal is an example of one such toolset that can render all the functionalities of Semantic Web technology right out of the box. Drupal’s content management system automatically stores the data in a structured format enabling it to be machine. Withinmore » this paper, we will discuss how Drupal promotes collaboration in a research setting such as Oak Ridge National Laboratory (ORNL) and Long Term Ecological Research Center (LTER) and how it is effectively using the Semantic Web in achieving this.« less

Towards semantic interoperability for electronic health records.

PubMed

Garde, Sebastian; Knaup, Petra; Hovenga, Evelyn; Heard, Sam

2007-01-01

In the field of open electronic health records (EHRs), openEHR as an archetype-based approach is being increasingly recognised. It is the objective of this paper to shortly describe this approach, and to analyse how openEHR archetypes impact on health professionals and semantic interoperability. Analysis of current approaches to EHR systems, terminology and standards developments. In addition to literature reviews, we organised face-to-face and additional telephone interviews and tele-conferences with members of relevant organisations and committees. The openEHR archetypes approach enables syntactic interoperability and semantic interpretability -- both important prerequisites for semantic interoperability. Archetypes enable the formal definition of clinical content by clinicians. To enable comprehensive semantic interoperability, the development and maintenance of archetypes needs to be coordinated internationally and across health professions. Domain knowledge governance comprises a set of processes that enable the creation, development, organisation, sharing, dissemination, use and continuous maintenance of archetypes. It needs to be supported by information technology. To enable EHRs, semantic interoperability is essential. The openEHR archetypes approach enables syntactic interoperability and semantic interpretability. However, without coordinated archetype development and maintenance, 'rank growth' of archetypes would jeopardize semantic interoperability. We therefore believe that openEHR archetypes and domain knowledge governance together create the knowledge environment required to adopt EHRs.

A legal framework to enable sharing of Clinical Decision Support knowledge and services across institutional boundaries.

PubMed

Hongsermeier, Tonya; Maviglia, Saverio; Tsurikova, Lana; Bogaty, Dan; Rocha, Roberto A; Goldberg, Howard; Meltzer, Seth; Middleton, Blackford

2011-01-01

The goal of the CDS Consortium (CDSC) is to assess, define, demonstrate, and evaluate best practices for knowledge management and clinical decision support in healthcare information technology at scale - across multiple ambulatory care settings and Electronic Health Record technology platforms. In the course of the CDSC research effort, it became evident that a sound legal foundation was required for knowledge sharing and clinical decision support services in order to address data sharing, intellectual property, accountability, and liability concerns. This paper outlines the framework utilized for developing agreements in support of sharing, accessing, and publishing content via the CDSC Knowledge Management Portal as well as an agreement in support of deployment and consumption of CDSC developed web services in the context of a research project under IRB oversight.

Continuum of eLearning: 2012 Project Summary Report

DTIC Science & Technology

2012-10-01

Taylor, Emilie Reitz, Kathleen Bartlett, and John Killilea DSCI MESH Solutions General Dynamics Information Technology 12601...goes on to write , “Joint Knowledge Online ( JKO) provides a Joint Indi- vidual Training Toolkit of web enabled individual and small group training...the interviews, we compiled relevant best practices from the academic literature. We call these “practical” limitations be- cause the technology and

Enabling the Future: Linking Science and Technology to Societal Goals. A Report.

ERIC Educational Resources Information Center

Carnegie Commission on Science, Technology, and Government, New York, NY.

This report seeks ways to improve the knowledge, understanding, and information available to the federal government on the long-term nature of the science and technology (S&T) enterprise as it relates to societal goals. The recommendations focus on a few key issues: improving the national capacity to define and revise long-term S&T goals; linking…

Web 2.0 in Education: The Impact of Discussion Board on Student Performance and Satisfaction

ERIC Educational Resources Information Center

AlJeraisy, Mashael Nasser; Mohammad, Heba; Fayyoumi, Ayham; Alrashideh, Waleed

2015-01-01

Web.2 technologies allow people to be the producer of information and this will increase the information in a network. Discussion Boards (forums) are Web.2 technology that enable student to interact, collaborate and exchange knowledge in different online courses. The main objective of this research study is to investigate the impact of Discussion…

The Study on Collaborative Manufacturing Platform Based on Agent

NASA Astrophysics Data System (ADS)

Zhang, Xiao-yan; Qu, Zheng-geng

To fulfill the trends of knowledge-intensive in collaborative manufacturing development, we have described multi agent architecture supporting knowledge-based platform of collaborative manufacturing development platform. In virtue of wrapper service and communication capacity agents provided, the proposed architecture facilitates organization and collaboration of multi-disciplinary individuals and tools. By effectively supporting the formal representation, capture, retrieval and reuse of manufacturing knowledge, the generalized knowledge repository based on ontology library enable engineers to meaningfully exchange information and pass knowledge across boundaries. Intelligent agent technology increases traditional KBE systems efficiency and interoperability and provides comprehensive design environments for engineers.

Introduction. Information, knowledge and technology.

PubMed

MacFarlane, Alistair G J

2003-08-15

Technology is the sum of the ways in which social groups manipulate order in the world to achieve their ends. It enables our active engagement with the world. Technology is central to our present well-being and vital for our future survival. As such it needs a coherent world view, a conceptual framework which will enable the fundamental problems that it poses for society to be approached in an illuminating way. Furthermore, such an approach, while remaining convincing, must not be overwhelmed by an ever-increasing welter of specialization and diversity of application. It is the purpose of the set of papers presented here to examine some key aspects of such a conceptual framework; not in the sense of offering a fully worked out philosophy of technology--that would be a huge and complex undertaking--but rather by considering some key topics. Subsidiary aims are to survey important relevant areas, to identify key sources that can provide access points for further study, and to consider some possible future developments. Major, coherent domains of activity are characterized by a few, fundamental, extensively used and essentially unifying concepts. Technology is such a domain, and its fundamental concepts are information, knowledge and agency. The following sections give a synoptic overview of the material presented in this theme issue, and set it within a wider context.

Human Research Program Exploration Medical Capability

NASA Technical Reports Server (NTRS)

Barsten, Kristina

2010-01-01

NASA s Human Research Program (HRP) conducts and coordinates research projects that provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. The Program is divided into 6 major elements, which a) Provide the Program s knowledge and capabilities to conduct research, addressing the human health and performance risks. b) Advance the readiness levels of technology and countermeasures to the point of transfer to the customer programs and organizations. The National Space Biomedical Research Institute (NSBRI) is a partner with the HRP in developing a successful research program. 3

GalenOWL: Ontology-based drug recommendations discovery

PubMed Central

2012-01-01

Background Identification of drug-drug and drug-diseases interactions can pose a difficult problem to cope with, as the increasingly large number of available drugs coupled with the ongoing research activities in the pharmaceutical domain, make the task of discovering relevant information difficult. Although international standards, such as the ICD-10 classification and the UNII registration, have been developed in order to enable efficient knowledge sharing, medical staff needs to be constantly updated in order to effectively discover drug interactions before prescription. The use of Semantic Web technologies has been proposed in earlier works, in order to tackle this problem. Results This work presents a semantic-enabled online service, named GalenOWL, capable of offering real time drug-drug and drug-diseases interaction discovery. For enabling this kind of service, medical information and terminology had to be translated to ontological terms and be appropriately coupled with medical knowledge of the field. International standards such as the aforementioned ICD-10 and UNII, provide the backbone of the common representation of medical data, while the medical knowledge of drug interactions is represented by a rule base which makes use of the aforementioned standards. Details of the system architecture are presented while also giving an outline of the difficulties that had to be overcome. A comparison of the developed ontology-based system with a similar system developed using a traditional business logic rule engine is performed, giving insights on the advantages and drawbacks of both implementations. Conclusions The use of Semantic Web technologies has been found to be a good match for developing drug recommendation systems. Ontologies can effectively encapsulate medical knowledge and rule-based reasoning can capture and encode the drug interactions knowledge. PMID:23256945

Semantic web for integrated network analysis in biomedicine.

PubMed

Chen, Huajun; Ding, Li; Wu, Zhaohui; Yu, Tong; Dhanapalan, Lavanya; Chen, Jake Y

2009-03-01

The Semantic Web technology enables integration of heterogeneous data on the World Wide Web by making the semantics of data explicit through formal ontologies. In this article, we survey the feasibility and state of the art of utilizing the Semantic Web technology to represent, integrate and analyze the knowledge in various biomedical networks. We introduce a new conceptual framework, semantic graph mining, to enable researchers to integrate graph mining with ontology reasoning in network data analysis. Through four case studies, we demonstrate how semantic graph mining can be applied to the analysis of disease-causal genes, Gene Ontology category cross-talks, drug efficacy analysis and herb-drug interactions analysis.

The application of wiki technology in medical education.

PubMed

Rasmussen, Andrew; Lewis, Melanie; White, Jonathan

2013-01-01

BACKGROUND, AIMS AND METHODS: Recent years have seen the introduction of web-based technologies such as the 'wiki', which is a webpage whose content can be edited in real time using a web browser. This article reviews the current state of knowledge about the use of wikis in education, and considers whether wiki technology has features that might prove useful in medical education. Advantages and challenges of the technology are discussed, and recommendations for use are provided. We believe that wiki technology offers a number of potential benefits for administrators, students and instructors, including the ability to share information online, to construct knowledge together, to facilitate collaboration and to enable social learning and peer feedback. We believe that with proper planning and instructional design, wiki technology can be usefully employed in medical education. We intend to continue to study the impact of wiki technology in our own programme, and we encourage others to evaluate the application of wiki technology in other areas of medical education.

Investigating Approaches to Achieve Modularity Benefits in the Acquisition Ecosystem

DTIC Science & Technology

2017-06-09

actions and that of others, and how the assessments are affected by their actions. • Case study approach based on best practices, tacit knowledge... case study -derived exemplars, and items requiring further research on identifying additional enablers and useful knowledge constructs. All of these... case studies that document the effective use of modularity in system design for some or all of innovation, competition, cost, technology and

Research and Technology 1999

NASA Technical Reports Server (NTRS)

2000-01-01

This report highlights the challenging work accomplished during fiscal year 1999 by Ames research scientists, engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments are grouped into four categories based on NASA's four Strategic Enterprises: Aero-Space Technology, Space, Human Exploration and Development of Space, and Earth Science. The primary purpose of this report is to communicate knowledge-to inform our stakeholders, customers, and partners, and the people of the United States about the scope and diversity of Ames' mission, the nature of Ames' research and technology activities, and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is making to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

Education, Technology and Health Literacy.

PubMed

Lindgren, Kurt; Koldkjær Sølling, Ina; Carøe, Per; Siggaard Mathiesen, Kirsten

2015-01-01

The purpose of this study is to develop an interdisciplinary learning environment between education in technology, business, and nursing. This collaboration creates natural interest and motivation for welfare technology. The aim of establishing an interaction between these three areas of expertise is to create an understanding of skills and cultural differences in each area. Futhermore, the aim is to enable future talents to gain knowledge and skills to improve health literacy among senior citizens. Based on a holistic view of welfare technology, a Student Academy was created as a theoretically- and practically-oriented learning center. The mission of the Student Academy is to support and facilitate education in order to maintain and upgrade knowledge and skills in information technology and information management related to e-health and health literacy. The Student Academy inspires students, stakeholders, politicians, DanAge Association members, companies, and professionals to participate in training, projects, workshops, and company visits.

Ames Research Center Research and Technology 2000

NASA Technical Reports Server (NTRS)

2002-01-01

This report highlights the challenging work accomplished during fiscal year 2000 by Ames research scientists,engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments are grouped into four categories based on four of NASA's Strategic Enterprises: Aerospace Technology, Space Science, Biological and Physical Research, and Earth Science. The primary purpose of this report is to communicate knowledge-to inform our stakeholders, customer, and partners, and the people of the United States about the scope and diversity of Ames' mission,the nature of Ames' research and technolog) activities,and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is willing to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

Research and Technology 1998

NASA Technical Reports Server (NTRS)

1999-01-01

This report highlights the challenging work accomplished during fiscal year 1998 by Ames research scientists, engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments are grouped into four categories based on NASA's four Strategic Enterprises: Aero-Space Technology, Space Science, Human Exploration and Development of Space, and Earth Science. The primary purpose of this report is to communicate knowledge-to inform our stakeholders, customers, and partners, and the people of the United States about the scope and diversity of Ames mission, the nature of Ames research and technology activities, and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is making to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

Contemporary HIV/AIDS research: Insights from knowledge management theory.

PubMed

Callaghan, Chris William

2017-12-01

Knowledge management as a field is concerned with the management of knowledge, including the management of knowledge in research processes. Knowledge management theory has the potential to support research into problems such as HIV, antibiotic resistance and others, particularly in terms of aspects of scientific research related to the contribution of social science. To date, however, these challenges remain with us, and theoretical contributions that can complement natural science efforts to eradicate these problems are needed. This paper seeks to offer a theoretical contribution grounded in Kuhn's paradigm theory of innovation, and in the argument by Lakatos that scientific research can be fundamentally non-innovative, which suggests that social science aspects of knowledge creation may hold the key to more effective biomedical innovation. Given the consequences of ongoing and emerging global crises, and the failure of knowledge systems of scientific research to solve such problems outright, this paper provides a review of theory and literature arguing for a new paradigm in scientific research, based on the development of global systems to maximise research collaborations. A global systems approach effectively includes social science theory development as an important complement to the natural sciences research process. Arguably, information technology and social media technology have developed to the point at which solutions to knowledge aggregation challenges can enable solutions to knowledge problems on a scale hitherto unimaginable. Expert and non-expert crowdsourced inputs can enable problem-solving through exponentially increasing problem-solving inputs, using the 'crowd,' thereby increasing collaborations dramatically. It is argued that these developments herald a new era of participatory research, or a democratisation of research, which offers new hope for solving global social problems. This paper seeks to contribute to this end, and to the recognition of the important role of social theory in the scientific research process.

Knowledge representation and management enabling intelligent interoperability - principles and standards.

PubMed

Blobel, Bernd

2013-01-01

Based on the paradigm changes for health, health services and underlying technologies as well as the need for at best comprehensive and increasingly automated interoperability, the paper addresses the challenge of knowledge representation and management for medical decision support. After introducing related definitions, a system-theoretical, architecture-centric approach to decision support systems (DSSs) and appropriate ways for representing them using systems of ontologies is given. Finally, existing and emerging knowledge representation and management standards are presented. The paper focuses on the knowledge representation and management part of DSSs, excluding the reasoning part from consideration.

New Technologies for Weather Accident Prevention

NASA Technical Reports Server (NTRS)

Stough, H. Paul, III; Watson, James F., Jr.; Daniels, Taumi S.; Martzaklis, Konstantinos S.; Jarrell, Michael A.; Bogue, Rodney K.

2005-01-01

Weather is a causal factor in thirty percent of all aviation accidents. Many of these accidents are due to a lack of weather situation awareness by pilots in flight. Improving the strategic and tactical weather information available and its presentation to pilots in flight can enhance weather situation awareness and enable avoidance of adverse conditions. This paper presents technologies for airborne detection, dissemination and display of weather information developed by the National Aeronautics and Space Administration (NASA) in partnership with the Federal Aviation Administration (FAA), National Oceanic and Atmospheric Administration (NOAA), industry and the research community. These technologies, currently in the initial stages of implementation by industry, will provide more precise and timely knowledge of the weather and enable pilots in flight to make decisions that result in safer and more efficient operations.

The lessons of Varsovian's reconnaissance

NASA Technical Reports Server (NTRS)

Bents, D. J.

1990-01-01

The role played by advanced technology is illustrated with respect to the anticipated era of discovery and exploration (in space): how bold new exploration initiatives may or may not be enabled. Enabling technology makes the mission feasible. To be truly enabling, however, the technology must not only render the proposed mission technically feasible, but also make it viable economically; that is, low enough in cost (relative to the economy supporting it) that urgent national need is not required for justification, low enough that risks can be programmatically tolerated. An allegorical parallel is drawn to the Roman Empire of the second century AD, shown to have possessed by that time the necessary knowledge, motivation, means, and technical capability of mounting, through the use of innovative mission planning, an initiative similar to Columbus' voyage. They failed to do so; not because they lacked the vision, but because their technology was not advanced enough to make it an acceptable proposition economically. Speculation, based on the historical perspective, is made on the outcome of contemporary plans for future exploration showing how they will be subjected to the same historical forces, within limits imposed by the state of technology development, that shaped the timing of that previous era of discovery and exploration.

IT and New Forms of Organisation for Knowledge Workers: Opportunity and Implementation.

ERIC Educational Resources Information Center

Coulson-Thomas, Colin

1991-01-01

Organizational flexibility is increasingly vital in business. The use of information technology allows people to work in whatever ways best enable them to contribute, through new patterns such as telecommuting. These new patterns require new approaches to personnel management. (JOW)

Information Technologies (ITs) in Medical Education.

PubMed

Masic, Izet; Pandza, Haris; Toromanovic, Selim; Masic, Fedja; Sivic, Suad; Zunic, Lejla; Masic, Zlatan

2011-09-01

Advances in medicine in recent decades are in significant correlation with the advances in the information technology. Modern information technologies (IT) have enabled faster, more reliable and comprehensive data collection. These technologies have started to create a large number of irrelevant information, which represents a limiting factor and a real growing gap, between the medical knowledge on one hand, and the ability of doctors to follow its growth on the other. Furthermore, in our environment, the term technology is generally reserved for its technical component. Education means, learning, teaching, or the process of acquiring skills or behavior modification through various exercises. Traditionally, medical education meant the oral, practical and more passive transferring of knowledge and skills from the educators to students and health professionals. For the clinical disciplines, of special importance are the principles, such as, "learning at bedside," aided by the medical literature. In doing so, these techniques enable students to contact with their teachers, and to refer to the appropriate literature. The disadvantage of these educational methods is in the fact, that teachers often do not have enough time. Additionally they are not very convenient to the horizontal and vertical integration of teaching, create weak or almost no self education, as well as, low skill levels and poor integration of education with a real social environment. In this paper authors describe application of modern IT in medical education - their advantages and disadvantages comparing with traditional ways of education.

Big, Deep, and Smart Data in Scanning Probe Microscopy

DOE PAGES

Kalinin, Sergei V.; Strelcov, Evgheni; Belianinov, Alex; ...

2016-09-27

Scanning probe microscopy techniques open the door to nanoscience and nanotechnology by enabling imaging and manipulation of structure and functionality of matter on nanometer and atomic scales. We analyze the discovery process by SPM in terms of information flow from tip-surface junction to the knowledge adoption by scientific community. Furthermore, we discuss the challenges and opportunities offered by merging of SPM and advanced data mining, visual analytics, and knowledge discovery technologies.

Bipolar disorder research 2.0: Web technologies for research capacity and knowledge translation.

PubMed

Michalak, Erin E; McBride, Sally; Barnes, Steven J; Wood, Chanel S; Khatri, Nasreen; Balram Elliott, Nusha; Parikh, Sagar V

2017-12-01

Current Web technologies offer bipolar disorder (BD) researchers many untapped opportunities for conducting research and for promoting knowledge exchange. In the present paper, we document our experiences with a variety of Web 2.0 technologies in the context of an international BD research network: The Collaborative RESearch Team to Study psychosocial issues in BD (CREST.BD). Three technologies were used as tools for enabling research within CREST.BD and for encouraging the dissemination of the results of our research: (1) the crestbd.ca website, (2) social networking tools (ie, Facebook, Twitter), and (3) several sorts of file sharing (ie YouTube, FileShare). For each Web technology, we collected quantitative assessments of their effectiveness (in reach, exposure, and engagement) over a 6-year timeframe (2010-2016). In general, many of our strategies were deemed successful for promoting knowledge exchange and other network goals. We discuss how we applied our Web analytics to inform adaptations and refinements of our Web 2.0 platforms to maximise knowledge exchange with people with BD, their supporters, and health care providers. We conclude with some general recommendations for other mental health researchers and research networks interested in pursuing Web 2.0 strategies. © 2017 John Wiley & Sons, Ltd.

Discussion of the enabling environments for decentralised water systems.

PubMed

Moglia, M; Alexander, K S; Sharma, A

2011-01-01

Decentralised water supply systems are becoming increasingly affordable and commonplace in Australia and have the potential to alleviate urban water shortages and reduce pollution into natural receiving marine and freshwater streams. Learning processes are necessary to support the efficient implementation of decentralised systems. These processes reveal the complex socio-technical and institutional factors to be considered when developing an enabling environment supporting decentralised water and wastewater servicing solutions. Critical to the technological transition towards established decentralised systems is the ability to create strategic and adaptive capacity to promote learning and dialogue. Learning processes require institutional mechanisms to ensure the lessons are incorporated into the formulation of policy and regulation, through constructive involvement of key government institutions. Engagement of stakeholders is essential to the enabling environment. Collaborative learning environments using systems analysis with communities (social learning) and adaptive management techniques are useful in refining and applying scientists' and managers' knowledge (knowledge management).

Agoraphobia and the Modern Learner

ERIC Educational Resources Information Center

Dron, Jon; Anderson, Terry

2014-01-01

Read/write social technologies enable rich pedagogies that centre on sharing and constructing content but have two notable weaknesses. Firstly, beyond the safe, nurturing environment of closed groups, students participating in more or less public network- or set-oriented communities may be insecure in their knowledge and skills, leading to…

GIS Enabled PBl Pedagogy: The Effects on Students' Learning in the Classroom

ERIC Educational Resources Information Center

Liu, Yan; Laxman, Kumar

2009-01-01

In efforts aimed at acquainting learners with "how to learn" skills rather than static content knowledge, more student centric instructional approaches are being increasingly adopted in informing curriculum design and delivery. Technology-rich problem solving environments offer great promise in scaffolding and facilitating…

Differentiation from First Principles Using Spreadsheets

ERIC Educational Resources Information Center

Lim, Kieran F.

2008-01-01

In the teaching of calculus, the algebraic derivation of the derivative (gradient function) enables the student to obtain an analytic "global" gradient function. However, to the best of this author's knowledge, all current technology-based approaches require the student to obtain the derivative (gradient) at a single point by…

Ventricular Assist Devices: Physiology Meets Technology

DTIC Science & Technology

1993-01-01

nmuse’s primary responsbility focuses on the patient . Expert clinical skills plus a thorugh - of the physiology behind VADs are necessary for a nurse...five roles of the CNS to effectively and efficiently manage VAD patients . Expert clinical skills and in-depth knowledge enables the CNS to anticipate

Next Generation Transport Concepts and Enabling Technology Research at NASA

NASA Technical Reports Server (NTRS)

Brown, Nelson

2013-01-01

This presentation will make USC aerospace engineering students aware of recent NASA contributions to aeronautics. Those students will likely use this knowledge for new aircraft designs in their careers. Topics covered in this presentation include, Blended Wing Body design, N+2 aircraft, and green aviation.

Information technology-enabled team-based, patient-centered care: The example of depression screening and management in cancer care.

PubMed

Randhawa, Gurvaneet S; Ahern, David K; Hesse, Bradford W

2017-03-01

The existing healthcare delivery systems across the world need to be redesigned to ensure high-quality care is delivered to all patients. This redesign needs to ensure care is knowledge-based, patient-centered and systems-minded. The rapid advances in the capabilities of information and communication technology and its recent rapid adoption in healthcare delivery have ensured this technology will play a vital role in the redesign of the healthcare delivery system. This commentary highlights promising new developments in health information technology (IT) that can support patient engagement and self-management as well as team-based, patient-centered care. Collaborative care is an effective approach to screen and treat depression in cancer patients and it is a good example of the benefits of team-based and patient-centered care. However, this approach was developed prior to the widespread adoption and use of health IT. We provide examples to illustrate how health IT can improve prevention and treatment of depression in cancer patients. We found several knowledge gaps that limit our ability to realize the full potential of health IT in the context of cancer and comorbid depression care. These gaps need to be filled to improve patient engagement; enhance the reach and effectiveness of collaborative care and web-based programs to prevent and treat depression in cancer patients. We also identify knowledge gaps in health IT design and implementation. Filling these gaps will help shape policies that enable clinical teams to deliver high-quality cancer care globally.

Preferences of Young Adults With First-Episode Psychosis for Receiving Specialized Mental Health Services Using Technology: A Survey Study.

PubMed

Lal, Shalini; Dell'Elce, Jennifer; Tucci, Natasha; Fuhrer, Rebecca; Tamblyn, Robyn; Malla, Ashok

2015-01-01

Despite the potential and interest of using technology for delivering specialized psychiatric services to young adults, surprisingly limited attention has been paid to systematically assess their perspectives in this regard. For example, limited knowledge exists on the extent to which young people receiving specialized services for a first-episode psychosis (FEP) are receptive to using new technologies as part of mental health care, and to which types of technology-enabled mental health interventions they are amenable to. The purpose of this study is to assess the interest of young adults with FEP in using technology to receive mental health information, services, and supports. This study uses a cross-sectional, descriptive survey design. A convenience sample of 67 participants between the ages of 18 and 35 were recruited from two specialized early intervention programs for psychosis. Interviewer-administered surveys were conducted between December 2013 and October 2014. Descriptive statistics are reported. Among the 67 respondents who completed the survey, the majority (85%, 57/67) agreed or strongly agreed with YouTube as a platform for mental health-related services and supports. The top five technology-enabled services that participants were amenable to were (1) information on medication (96%, 64/67); (2) information on education, career, and employment (93%, 62/67); (3) decision-making tools pertaining to treatment and recovery (93%, 62/67); (4) reminders for appointments via text messaging (93%, 62/67); and (5) information about mental health, psychosis, and recovery in general (91%, 61/67). The top self-reported barriers to seeking mental health information online were lack of knowledge on how to perform an Internet search (31%, 21/67) and the way information is presented online (27%, 18/67). Two thirds (67%; 45/67) reported being comfortable in online settings, and almost half (48%; 32/67) reported a preference for mixed formats when viewing mental health information online (eg, text, video, visual graphics). Young people diagnosed with FEP express interest in using the Internet, social media, and mobile technologies for receiving mental health-related services. Increasing the awareness of young people in relation to various forms of technology-enabled mental health care warrants further attention. A consideration for future research is to obtain more in-depth knowledge on young people's perspectives, which can help improve the design, development, and implementation of integrated technological health innovations within the delivery of specialized mental health care.

The interaction of representation and reasoning.

PubMed

Bundy, Alan

2013-09-08

Automated reasoning is an enabling technology for many applications of informatics. These applications include verifying that a computer program meets its specification; enabling a robot to form a plan to achieve a task and answering questions by combining information from diverse sources, e.g. on the Internet, etc. How is automated reasoning possible? Firstly, knowledge of a domain must be stored in a computer, usually in the form of logical formulae. This knowledge might, for instance, have been entered manually, retrieved from the Internet or perceived in the environment via sensors, such as cameras. Secondly, rules of inference are applied to old knowledge to derive new knowledge. Automated reasoning techniques have been adapted from logic, a branch of mathematics that was originally designed to formalize the reasoning of humans, especially mathematicians. My special interest is in the way that representation and reasoning interact. Successful reasoning is dependent on appropriate representation of both knowledge and successful methods of reasoning. Failures of reasoning can suggest changes of representation. This process of representational change can also be automated. We will illustrate the automation of representational change by drawing on recent work in my research group.

Big, Deep, and Smart Data in Scanning Probe Microscopy.

PubMed

Kalinin, Sergei V; Strelcov, Evgheni; Belianinov, Alex; Somnath, Suhas; Vasudevan, Rama K; Lingerfelt, Eric J; Archibald, Richard K; Chen, Chaomei; Proksch, Roger; Laanait, Nouamane; Jesse, Stephen

2016-09-27

Scanning probe microscopy (SPM) techniques have opened the door to nanoscience and nanotechnology by enabling imaging and manipulation of the structure and functionality of matter at nanometer and atomic scales. Here, we analyze the scientific discovery process in SPM by following the information flow from the tip-surface junction, to knowledge adoption by the wider scientific community. We further discuss the challenges and opportunities offered by merging SPM with advanced data mining, visual analytics, and knowledge discovery technologies.

Sonic Boom Modeling Technical Challenge

NASA Technical Reports Server (NTRS)

Sullivan, Brenda M.

2007-01-01

This viewgraph presentation reviews the technical challenges in modeling sonic booms. The goal of this program is to develop knowledge, capabilities and technologies to enable overland supersonic flight. The specific objectives of the modeling are: (1) Develop and validate sonic boom propagation model through realistic atmospheres, including effects of turbulence (2) Develop methods enabling prediction of response of and acoustic transmission into structures impacted by sonic booms (3) Develop and validate psychoacoustic model of human response to sonic booms under both indoor and outdoor listening conditions, using simulators.

Integration of problem-based learning and innovative technology into a self-care course.

PubMed

McFalls, Marsha

2013-08-12

To assess the integration of problem-based learning and technology into a self-care course. Problem-based learning (PBL) activities were developed and implemented in place of lectures in a self-care course. Students used technology, such as computer-generated virtual patients and iPads, during the PBL sessions. Students' scores on post-case quizzes were higher than on pre-case quizzes used to assess baseline knowledge. Student satisfaction with problem-based learning and the use of technology in the course remained consistent throughout the semester. Integrating problem-based learning and technology into a self-care course enabled students to become active learners.

PEER Transportation Research Program | PEER Transportation Research Program

Science.gov Websites

methodologies, integrating fundamental knowledge, enabling technologies, and systems. We further expect that the Bayesian Framework for Performance Assessment and Risk Management of Transportation Systems subject to Earthquakes Directivity Modeling for NGA West2 Ground Motion Studies for Transportation Systems Performance

Collaborative Doctoral Programmes: Employer Engagement, Knowledge Mediation and Skills for Innovation

ERIC Educational Resources Information Center

Kitagawa, Fumi

2014-01-01

This paper investigates forms of collaborative doctoral programmes that enable employer engagement in innovation and skills development. Collaborative doctoral programmes exist in different national contexts for the development of the science and technology human capital. Such programmes are also seen as policy tools that enhance relationships…

Equalizing Educational Opportunities by ICT

ERIC Educational Resources Information Center

Delgado García, Ana María; Torrubia Chalmeta, Blanca

2016-01-01

The Open University of Catalonia (UOC) is a pioneer university in the use of technology for online learning. The virtual teaching system enables to acquire professionalizing competences and facilitates the practitioners the update of knowledge in an optimum way. That is possible, on one hand, thanks to the resources for theoretical and practical…

Human Research Program Opportunities

NASA Technical Reports Server (NTRS)

Kundrot, Craig E.

2014-01-01

The goal of HRP is to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. The Human Research Program was designed to meet the needs of human space exploration, and understand and reduce the risk to crew health and performance in exploration missions.

Developing a National STEM Workforce Strategy: A Workshop Summary

ERIC Educational Resources Information Center

Alper, Joe

2016-01-01

The future competitiveness of the United States in an increasingly interconnected global economy depends on the nation fostering a workforce with strong capabilities and skills in science, technology, engineering, and mathematics (STEM). STEM knowledge and skills enable both individual opportunity and national competitiveness, and the nation needs…

Activity Theory and Ontology

ERIC Educational Resources Information Center

Peim, Nick

2009-01-01

This paper seeks to re-examine Yrio Engestrom's activity theory as a technology of knowledge designed to enable positive transformations of specific practices. The paper focuses on a key paper where Engestrom defines the nature and present state of activity theory. Beginning with a brief account of the relations between activity theory and…

Is There a Teacher in This Class? Information Processing, Multimedia and Education

ERIC Educational Resources Information Center

Muralikrishnan, T. R.; Sanjayan, T. S.

2009-01-01

This paper proposes to discuss the concept of multimedia using information processing theory in ICT enabled teacher education in the context of a knowledge society. The Information and communication technology (ICT) competencies required of teachers related to content, pedagogy, technical issues, social issues, collaboration and networking remain…

Innovating Teacher Education in a Complex Era

ERIC Educational Resources Information Center

Tan, Oon Seng

2015-01-01

The meteoric increase in technological advancement in the last few decades has dramatically transformed how people live their lives. Innovation is seen to be essential as it ensures sustainable growth in a knowledge-based economy and a competitive global marketplace. Consequently, enabling innovation to occur becomes of prime concern to educators…

Comparative Analysis of Palm and Wearable Computers for Participatory Simulations

ERIC Educational Resources Information Center

Klopfer, Eric; Yoon, Susan; Rivas, Luz

2004-01-01

Recent educational computer-based technologies have offered promising lines of research that promote social constructivist learning goals, develop skills required to operate in a knowledge-based economy (Roschelle et al. 2000), and enable more authentic science-like problem-solving. In our research programme, we have been interested in combining…

Technology is a critical game changer to the practice of dental hygiene.

PubMed

Gadbury-Amyot, Cynthia C

2014-06-01

Dental hygienists will need to embrace 21st century technology to adapt to workplace settings. To stay relevant in the workforce, dental hygienists need mastery of new skills and technologies. The purpose of this paper is to elucidate the vast array of technological advances impacting dental practice and the consequent implications for oral health care providers. New technologies have provided unparalleled opportunities for degree and career advancement for dental hygienists. Advances in science and technology are providing patients with better quality and more convenient oral health care. Dental hygienists need technological skills that enable them to fully utilize technology as a strategy for consultation with dentists and other health care professionals and for other purposes. Continuing education and life-long learning factor into preparing dental hygienists for 21st century technologies. With technological advances, less adaptive professionals could potentially see a decrease in demand for their services. Possessing a high level of knowledge of dentistry and dental hygiene does not ensure a position in the workforce. Knowledge of technologies and associated skills are required for quality patient care and career and personal growth. Copyright © 2014 Elsevier Inc. All rights reserved.

Methods for optimizing solutions when considering group arguments by team of experts

NASA Astrophysics Data System (ADS)

Chernyi, Sergei; Budnik, Vlad

2017-11-01

The article is devoted to methods of expert evaluation. The technology of expert evaluation is presented from the standpoint of precedent structures. In this paper, an aspect of the mathematical basis for constructing a component of decision analysis is considered. In fact, this approach leaves out any identification of their knowledge and skills of simulating organizational and manufacturing situations and taking efficient managerial decisions; it doesn't enable any identification and assessment of their knowledge on the basis of multi-informational and least loss-making methods and information technologies. Hence the problem is to research and develop a methodology for systemic identification of professional problem-focused knowledge acquired by employees operating adaptive automated systems of training management (AASTM operators), which shall also further the theory and practice of the intelligence-related aspects thereof.

Software Sharing Enables Smarter Content Management

NASA Technical Reports Server (NTRS)

2007-01-01

In 2004, NASA established a technology partnership with Xerox Corporation to develop high-tech knowledge management systems while providing new tools and applications that support the Vision for Space Exploration. In return, NASA provides research and development assistance to Xerox to progress its product line. The first result of the technology partnership was a new system called the NX Knowledge Network (based on Xerox DocuShare CPX). Created specifically for NASA's purposes, this system combines Netmark-practical database content management software created by the Intelligent Systems Division of NASA's Ames Research Center-with complementary software from Xerox's global research centers and DocuShare. NX Knowledge Network was tested at the NASA Astrobiology Institute, and is widely used for document management at Ames, Langley Research Center, within the Mission Operations Directorate at Johnson Space Center, and at the Jet Propulsion Laboratory, for mission-related tasks.

From the Bench to the Bedside: The Role of Semantic Web and Translational Medicine for Enabling the Next Generation Healthcare Enterprise

NASA Astrophysics Data System (ADS)

Kashyap, Vipul

The success of new innovations and technologies are very often disruptive in nature. At the same time, they enable novel next generation infrastructures and solutions. These solutions introduce great efficiencies in the form of efficient processes and the ability to create, organize, share and manage knowledge effectively; and the same time provide crucial enablers for proposing and realizing new visions. In this paper, we propose a new vision of the next generation healthcare enterprise and discuss how Translational Medicine, which aims to improve communication between the basic and clinical sciences, is a key requirement for achieving this vision. This will lead therapeutic insights may be derived from new scientific ideas - and vice versa. Translation research goes from bench to bedside, where theories emerging from preclinical experimentation are tested on disease-affected human subjects, and from bedside to bench, where information obtained from preliminary human experimentation can be used to refine our understanding of the biological principles underpinning the heterogeneity of human disease and polymorphism(s). Informatics and semantic technologies in particular, has a big role to play in making this a reality. We identify critical requirements, viz., data integration, clinical decision support and knowledge maintenance and provenance; and illustrate semantics-based solutions wrt example scenarios and use cases.

Information Systems for NASA's Aeronautics and Space Enterprises

NASA Technical Reports Server (NTRS)

Kutler, Paul

1998-01-01

The aerospace industry is being challenged to reduce costs and development time as well as utilize new technologies to improve product performance. Information technology (IT) is the key to providing revolutionary solutions to the challenges posed by the increasing complexity of NASA's aeronautics and space missions and the sophisticated nature of the systems that enable them. The NASA Ames vision is to develop technologies enabling the information age, expanding the frontiers of knowledge for aeronautics and space, improving America's competitive position, and inspiring future generations. Ames' missions to accomplish that vision include: 1) performing research to support the American aviation community through the unique integration of computation, experimentation, simulation and flight testing, 2) studying the health of our planet, understanding living systems in space and the origins of the universe, developing technologies for space flight, and 3) to research, develop and deliver information technologies and applications. Information technology may be defined as the use of advance computing systems to generate data, analyze data, transform data into knowledge and to use as an aid in the decision-making process. The knowledge from transformed data can be displayed in visual, virtual and multimedia environments. The decision-making process can be fully autonomous or aided by a cognitive processes, i.e., computational aids designed to leverage human capacities. IT Systems can learn as they go, developing the capability to make decisions or aid the decision making process on the basis of experiences gained using limited data inputs. In the future, information systems will be used to aid space mission synthesis, virtual aerospace system design, aid damaged aircraft during landing, perform robotic surgery, and monitor the health and status of spacecraft and planetary probes. NASA Ames through the Center of Excellence for Information Technology Office is leading the effort in pursuit of revolutionary, IT-based approaches to satisfying NASA's aeronautics and space requirements. The objective of the effort is to incorporate information technologies within each of the Agency's four Enterprises, i.e., Aeronautics and Space Transportation Technology, Earth, Science, Human Exploration and Development of Space and Space Sciences. The end results of these efforts for Enterprise programs and projects should be reduced cost, enhanced mission capability and expedited mission completion.

EO Domain Specific Knowledge Enabled Services (KES-B)

NASA Astrophysics Data System (ADS)

Varas, J.; Busto, J.; Torguet, R.

2004-09-01

This paper recovers and describes a number of major statements with respect to the vision, mission and technological approaches of the Technological Research Project (TRP) "EO Domain Specific Knowledge Enabled Services" (project acronym KES-B), which is currently under development at the European Space Research Institute (ESRIN) under contract "16397/02/I- SB". Resulting from the on-going R&D activities, the KES-B project aims are to demonstrate with a prototype system the feasibility of the application of innovative knowledge-based technologies to provide services for easy, scheduled and controlled exploitation of EO resources (e.g.: data, algorithms, procedures, storage, processors, ...), to automate the generation of products, and to support users in easily identifying and accessing the required information or products by using their own vocabulary, domain knowledge and preferences. The ultimate goals of KES-B are summarized in the provision of the two main types of KES services: 1st the Search service (also referred to as Product Exploitation or Information Retrieval; and 2nd the Production service (also referred to as Information Extraction), with the strategic advantage that they are enabled by Knowledge consolidated (formalized) within the system. The KES-B system technical solution approach is driven by a strong commitment for the adoption of industry (XML-based) language standards, aiming to have an interoperable, scalable and flexible operational prototype. In that sense, the Search KES services builds on the basis of the adoption of consolidated and/or emergent W3C semantic-web standards. Remarkably the languages/models Dublin Core (DC), Universal Resource Identifier (URI), Resource Description Framework (RDF) and Ontology Web Language (OWL), and COTS like Protege [1] and JENA [2] are being integrated in the system as building bricks for the construction of the KES based Search services. On the other hand, the Production KES services builds on top of workflow management standards and tools. In this side, the Business Process Execution Language (BPEL), the Web Services Definition Language (WSDL), and the Collaxa [3] COTS tool for workflow management are being integrated for the construction of the KES-B Production Services. The KES-B platform (web portal and web-server) architecture is build on the basis of the J2EE reference architecture. These languages represent the mean for the codification of the different types of knowledge that are to be formalized in the system. This representing the ontological architecture of the system. This shall enable in fact the interoperability with other KES-based systems committing as well to those standards. The motivation behind this vision is pointing towards the construction of the Semantic-web based GRID supply- chain infrastructure for EO-services, in line with the INSPIRE initiative suggestions.

Research and Technology 1996

NASA Technical Reports Server (NTRS)

1997-01-01

This report highlights the challenging work accomplished during fiscal year 1996 by Ames research scientists, engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments span the range of goals of NASA's four Strategic Enterprises: (1) Aeronautics and Space Transportation Technology, (2) Space Science, (3) Human Exploration and Development of Space, and (4) Mission to Planet Earth. The primary purpose of this report is to communicate knowledge--to inform our stakeholders, customers, and partners, and the people of the United States about the scope and diversity of Ames' mission, the nature of Ames' research and technology activities, and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is making to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

Ontology-Based Gap Analysis for Technology Selection: A Knowledge Management Framework for the Support of Equipment Purchasing Processes

NASA Astrophysics Data System (ADS)

Macris, Aristomenis M.; Georgakellos, Dimitrios A.

Technology selection decisions such as equipment purchasing and supplier selection are decisions of strategic importance to companies. The nature of these decisions usually is complex, unstructured and thus, difficult to be captured in a way that will be efficiently reusable. Knowledge reusability is of paramount importance since it enables users participate actively in process design/redesign activities stimulated by the changing technology selection environment. This paper addresses the technology selection problem through an ontology-based approach that captures and makes reusable the equipment purchasing process and assists in identifying (a) the specifications requested by the users' organization, (b) those offered by various candidate vendors' organizations and (c) in performing specifications gap analysis as a prerequisite for effective and efficient technology selection. This approach has practical appeal, operational simplicity, and the potential for both immediate and long-term strategic impact. An example from the iron and steel industry is also presented to illustrate the approach.

Advanced Concepts, Technologies and Flight Experiments for NASA's Earth Science Enterprise

NASA Technical Reports Server (NTRS)

Meredith, Barry D.

2000-01-01

Over the last 25 years, NASA Langley Research Center (LaRC) has established a tradition of excellence in scientific research and leading-edge system developments, which have contributed to improved scientific understanding of our Earth system. Specifically, LaRC advances knowledge of atmospheric processes to enable proactive climate prediction and, in that role, develops first-of-a-kind atmospheric sensing capabilities that permit a variety of new measurements to be made within a constrained enterprise budget. These advances are enabled by the timely development and infusion of new, state-of-the-art (SOA), active and passive instrument and sensor technologies. In addition, LaRC's center-of-excellence in structures and materials is being applied to the technological challenges of reducing measurement system size, mass, and cost through the development and use of space-durable materials; lightweight, multi-functional structures; and large deployable/inflatable structures. NASA Langley is engaged in advancing these technologies across the full range of readiness levels from concept, to components, to prototypes, to flight experiments, and on to actual science mission infusion. The purpose of this paper is to describe current activities and capabilities, recent achievements, and future plans of the integrated science, engineering, and technology team at Langley Research Center who are working to enable the future of NASA's Earth Science Enterprise.

An Enabling Technology for New Planning and Scheduling Paradigms

NASA Technical Reports Server (NTRS)

Jaap, John; Davis, Elizabeth

2004-01-01

The Night Projects Directorate at NASA's Marshall Space Flight Center is developing a new planning and scheduling environment and a new scheduling algorithm to enable a paradigm shift in planning and scheduling concepts. Over the past 33 years Marshall has developed and evolved a paradigm for generating payload timelines for Skylab, Spacelab, various other Shuttle payloads, and the International Space Station. The current paradigm starts by collecting the requirements, called ?ask models," from the scientists and technologists for the tasks that are to be scheduled. Because of shortcomings in the current modeling schema, some requirements are entered as notes. Next, a cadre with knowledge of vehicle and hardware modifies these models to encompass and be compatible with the hardware model; again, notes are added when the modeling schema does not provide a better way to represent the requirements. Finally, the models are modified to be compatible with the scheduling engine. Then the models are submitted to the scheduling engine for automatic scheduling or, when requirements are expressed in notes, the timeline is built manually. A future paradigm would provide a scheduling engine that accepts separate science models and hardware models. The modeling schema would have the capability to represent all the requirements without resorting to notes. Furthermore, the scheduling engine would not require that the models be modified to account for the capabilities (limitations) of the scheduling engine. The enabling technology under development at Marshall has three major components: (1) A new modeling schema allows expressing all the requirements of the tasks without resorting to notes or awkward contrivances. The chosen modeling schema is both maximally expressive and easy to use. It utilizes graphical methods to show hierarchies of task constraints and networks of temporal relationships. (2) A new scheduling algorithm automatically schedules the models without the intervention of a scheduling expert. The algorithm is tuned for the constraint hierarchies and the complex temporal relationships provided by the modeling schema. It has an extensive search algorithm that can exploit timing flexibilities and constraint and relationship options. (3) An innovative architecture allows multiple remote users to simultaneously model science and technology requirements and other users to model vehicle and hardware characteristics. The architecture allows the remote users to submit scheduling requests directly to the scheduling engine and immediately see the results. These three components are integrated so that science and technology experts with no knowledge of the vehicle or hardware subsystems and no knowledge of the internal workings of the scheduling engine have the ability to build and submit scheduling requests and see the results. The immediate feedback will hone the users' modeling skills and ultimately enable them to produce the desired timeline. This paper summarizes the three components of the enabling technology and describes how this technology would make a new paradigm possible.

ARMD Strategic Thrust 6: Assured Autonomy for Aviation Transformation

NASA Technical Reports Server (NTRS)

Ballin, Mark; Holbrook, Jon; Sharma, Shivanjli

2016-01-01

In collaboration with the external community and other government agencies, NASA will develop enabling technologies, standards, and design guidelines to support cost-effective applications of automation and limited autonomy for individual components of aviation systems. NASA will also provide foundational knowledge and methods to support the next epoch. Research will address issues of verification and validation, operational evaluation, national policy, and societal cost-benefit. Two research and development approaches to aviation autonomy will advance in parallel. The Increasing Autonomy (IA) approach will seek to advance knowledge and technology through incremental increases in machine-based support of existing human-centered tasks, leading to long-term reallocation of functions between humans and machines. The Autonomy as a New Technology (ANT) approach seeks advances by developing technology to achieve goals that are not currently possible using human-centered concepts of operation. IA applications are mission-enhancing, and their selection will be based on benefits achievable relative to existing operations. ANT applications are mission-enabling, and their value will be assessed based on societal benefit resulting from a new capability. The expected demand for small autonomous unmanned aircraft systems (UAS) provides an opportunity for development of ANT applications. Supervisory autonomy may be implemented as an expansion of the number of functions or systems that may be controlled by an individual human operator. Convergent technology approaches, such as the use of electronic flight bags and existing network servers, will be leveraged to the maximum extent possible.

Information Technologies (ITs) in Medical Education

PubMed Central

Masic, Izet; Pandza, Haris; Toromanovic, Selim; Masic, Fedja; Sivic, Suad; Zunic, Lejla; Masic, Zlatan

2011-01-01

Advances in medicine in recent decades are in significant correlation with the advances in the information technology. Modern information technologies (IT) have enabled faster, more reliable and comprehensive data collection. These technologies have started to create a large number of irrelevant information, which represents a limiting factor and a real growing gap, between the medical knowledge on one hand, and the ability of doctors to follow its growth on the other. Furthermore, in our environment, the term technology is generally reserved for its technical component. Education means, learning, teaching, or the process of acquiring skills or behavior modification through various exercises. Traditionally, medical education meant the oral, practical and more passive transferring of knowledge and skills from the educators to students and health professionals. For the clinical disciplines, of special importance are the principles, such as, “learning at bedside,” aided by the medical literature. In doing so, these techniques enable students to contact with their teachers, and to refer to the appropriate literature. The disadvantage of these educational methods is in the fact, that teachers often do not have enough time. Additionally they are not very convenient to the horizontal and vertical integration of teaching, create weak or almost no self education, as well as, low skill levels and poor integration of education with a real social environment. In this paper authors describe application of modern IT in medical education – their advantages and disadvantages comparing with traditional ways of education. PMID:23408471

Innovation strategy management survey of the Chilean biomedical industry. Assessment of windows of opportunities to reduce technological gaps.

PubMed

Bas, Tomas Gabriel; Oliu, Carolina Alejandra

2018-04-01

The convergence of different theories (ie, catch-up effect and windows of opportunities) allows for the interpretation of different "technological innovation gaps" in Chile's biomedical industry. It is common knowledge that Chile has always had an economy almost exclusively based on services, commodities, and mainly in the exploitation of natural resources with low value added. The literature confirms that countries that concentrate their economies on the knowledge, research, development, and commercialization of technology and innovation have a better and more stable growth rate in the medium and long run. The "Asian Tigers" are a good example of this. Analyzing the technological gaps that affect the Chilean biomedical industry, it is possible to find windows of opportunities to catch up. This could allow the country to take its knowledge, skills, and capabilities further, thus enabling Chile to not just depend on its unpredictable natural resources. For the first time, a quantitative diagnosis of the Chilean biomedical industry was made. This study considered the Chilean biomedical industry and its innovation and entrepreneurship environment, taking into account its productive capacities and its potential to make progress in technological innovation and, as a result, dramatically reducing technological gaps through windows of opportunities. Copyright © 2018 John Wiley & Sons, Ltd.

Contemporary HIV/AIDS research: Insights from knowledge management theory

PubMed Central

Callaghan, Chris William

2017-01-01

Abstract Knowledge management as a field is concerned with the management of knowledge, including the management of knowledge in research processes. Knowledge management theory has the potential to support research into problems such as HIV, antibiotic resistance and others, particularly in terms of aspects of scientific research related to the contribution of social science. To date, however, these challenges remain with us, and theoretical contributions that can complement natural science efforts to eradicate these problems are needed. This paper seeks to offer a theoretical contribution grounded in Kuhn’s paradigm theory of innovation, and in the argument by Lakatos that scientific research can be fundamentally non-innovative, which suggests that social science aspects of knowledge creation may hold the key to more effective biomedical innovation. Given the consequences of ongoing and emerging global crises, and the failure of knowledge systems of scientific research to solve such problems outright, this paper provides a review of theory and literature arguing for a new paradigm in scientific research, based on the development of global systems to maximise research collaborations. A global systems approach effectively includes social science theory development as an important complement to the natural sciences research process. Arguably, information technology and social media technology have developed to the point at which solutions to knowledge aggregation challenges can enable solutions to knowledge problems on a scale hitherto unimaginable. Expert and non-expert crowdsourced inputs can enable problem-solving through exponentially increasing problem-solving inputs, using the ‘crowd,’ thereby increasing collaborations dramatically. It is argued that these developments herald a new era of participatory research, or a democratisation of research, which offers new hope for solving global social problems. This paper seeks to contribute to this end, and to the recognition of the important role of social theory in the scientific research process. PMID:28922967

Implementing Science-Technology-Society Approaches in Middle School Science Teaching

ERIC Educational Resources Information Center

Akcay, Hakan; Yager, Robert E.

2010-01-01

The National Science Education Standards emphasize a goal that students should achieve scientific literacy, which is defined as the knowledge and understanding of scientific concepts needed in daily living. Scientific literacy enables people to not only use scientific principles and processes in making personal decisions but also to participate in…

Increasing Middle School Student Interest in STEM Careers with Videos of Scientists

ERIC Educational Resources Information Center

Wyss, Vanessa L.; Heulskamp, Diane; Siebert, Cathy J.

2012-01-01

Students are making choices in middle school that will impact their desire and ability to pursue STEM careers. Providing middle school students with accurate information about STEM (Science, Technology, Engineering, Mathematics) careers enables them to make more knowledgeable choices about courses of study and career paths. Practical ways of…

Clinical Interpretation of Variants in Cancer (CIViC) Knowledgebase | Informatics Technology for Cancer Research (ITCR)

Cancer.gov

CIViC is an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer. Our goal is to enable precision medicine by providing an educational forum for dissemination of knowledge and active discussion of the clinical significance of cancer genome alterations.

Benefits for Health; NASA

NASA Technical Reports Server (NTRS)

Perchonok, Michele

2014-01-01

The goal of HRP is to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. Presentation discusses (1) Bone Health: Vitamin D, Fish Consumption and Exercise (2) Medical Support in Remote Areas (3) ISS Ultrasound 4) Dry electrode EKG System (5) Environmental Factors and Psychological Health.

Transfer of Online Professional Learning to Teachers' Classroom Practice

ERIC Educational Resources Information Center

Herrington, Anthony; Herrington, Jan; Hoban, Garry; Reid, Doug

2009-01-01

Professional learning is an important process in enabling teachers to update their pedagogical knowledge and practices. The use of online technologies to support professional learning has a number of benefits in terms of flexibility and scalability. However, it is not clear how well the approach impacts on teachers' classroom practices. This…

Commit to Building on New England's "Employability" Advantage!

ERIC Educational Resources Information Center

Gittell, Ross

2017-01-01

Higher education has provided New England with an economic advantage, as the region without strong natural resource advantages has relied on its higher education institutions (HEIs) and brainpower. A higher education-based economic advantage has enabled the region to develop strong well-paying technology and knowledge-based industries tied to New…

Computation as the mechanistic bridge between precision medicine and systems therapeutics.

PubMed

Hansen, J; Iyengar, R

2013-01-01

Over the past 50 years, like molecular cell biology, medicine and pharmacology have been driven by a reductionist approach. The focus on individual genes and cellular components as disease loci and drug targets has been a necessary step in understanding the basic mechanisms underlying tissue/organ physiology and drug action. Recent progress in genomics and proteomics, as well as advances in other technologies that enable large-scale data gathering and computational approaches, is providing new knowledge of both normal and disease states. Systems-biology approaches enable integration of knowledge from different types of data for precision medicine and systems therapeutics. In this review, we describe recent studies that contribute to these emerging fields and discuss how together these fields can lead to a mechanism-based therapy for individual patients.

Computation as the Mechanistic Bridge Between Precision Medicine and Systems Therapeutics

PubMed Central

Hansen, J; Iyengar, R

2014-01-01

Over the past 50 years, like molecular cell biology, medicine and pharmacology have been driven by a reductionist approach. The focus on individual genes and cellular components as disease loci and drug targets has been a necessary step in understanding the basic mechanisms underlying tissue/organ physiology and drug action. Recent progress in genomics and proteomics, as well as advances in other technologies that enable large-scale data gathering and computational approaches, is providing new knowledge of both normal and disease states. Systems-biology approaches enable integration of knowledge from different types of data for precision medicine and systems therapeutics. In this review, we describe recent studies that contribute to these emerging fields and discuss how together these fields can lead to a mechanism-based therapy for individual patients. PMID:23212109

Status of ERA Vehicle System Integration Technology Demonstrators

NASA Technical Reports Server (NTRS)

Flamm, Jeffrey D.; Fernandez, Hamilton; Khorrami, Mehdi; James, Kevin D.; Thomas, Russell

2015-01-01

The Environmentally Responsible Aviation (ERA) Project within the Integrated Systems Research Program (ISRP) of the NASA Aeronautics Research Mission Directorate (ARMD) has the responsibility to explore and document the feasibility, benefits, and technical risk of air vehicle concepts and enabling technologies that will reduce the impact of aviation on the environment. The primary goal of the ERA Project is to select air vehicle concepts and technologies that can simultaneously reduce fuel burn, noise, and emissions. In addition, the ERA Project will identify and mitigate technical risk and transfer knowledge to the aeronautics community at large so that new technologies and vehicle concepts can be incorporated into the future design of aircraft.

Patient-centered applications: use of information technology to promote disease management and wellness. A white paper by the AMIA knowledge in motion working group.

PubMed

Demiris, George; Afrin, Lawrence B; Speedie, Stuart; Courtney, Karen L; Sondhi, Manu; Vimarlund, Vivian; Lovis, Christian; Goossen, William; Lynch, Cecil

2008-01-01

Advances in information technology (IT) enable a fundamental redesign of health care processes based on the use and integration of electronic communication at all levels. New communication technologies can support a transition from institution centric to patient-centric applications. This white paper defines key principles and challenges for designers, policy makers, and evaluators of patient-centered technologies for disease management and prevention. It reviews current and emerging trends; highlights challenges related to design, evaluation, reimbursement and usability; and reaches conclusions for next steps that will advance the domain.

Patient-centered Applications: Use of Information Technology to Promote Disease Management and Wellness. A White Paper by the AMIA Knowledge in Motion Working Group

PubMed Central

Demiris, George; Afrin, Lawrence B.; Speedie, Stuart; Courtney, Karen L.; Sondhi, Manu; Vimarlund, Vivian; Lovis, Christian; Goossen, William; Lynch, Cecil

2008-01-01

Advances in information technology (IT) enable a fundamental redesign of health care processes based on the use and integration of electronic communication at all levels. New communication technologies can support a transition from institution centric to patient-centric applications. This white paper defines key principles and challenges for designers, policy makers, and evaluators of patient-centered technologies for disease management and prevention. It reviews current and emerging trends; highlights challenges related to design, evaluation, reimbursement and usability; and reaches conclusions for next steps that will advance the domain. PMID:17947617

TRIAD: The Translational Research Informatics and Data Management Grid

PubMed Central

Payne, P.; Ervin, D.; Dhaval, R.; Borlawsky, T.; Lai, A.

2011-01-01

Objective Multi-disciplinary and multi-site biomedical research programs frequently require infrastructures capable of enabling the collection, management, analysis, and dissemination of heterogeneous, multi-dimensional, and distributed data and knowledge collections spanning organizational boundaries. We report on the design and initial deployment of an extensible biomedical informatics platform that is intended to address such requirements. Methods A common approach to distributed data, information, and knowledge management needs in the healthcare and life science settings is the deployment and use of a service-oriented architecture (SOA). Such SOA technologies provide for strongly-typed, semantically annotated, and stateful data and analytical services that can be combined into data and knowledge integration and analysis “pipelines.” Using this overall design pattern, we have implemented and evaluated an extensible SOA platform for clinical and translational science applications known as the Translational Research Informatics and Data-management grid (TRIAD). TRIAD is a derivative and extension of the caGrid middleware and has an emphasis on supporting agile “working interoperability” between data, information, and knowledge resources. Results Based upon initial verification and validation studies conducted in the context of a collection of driving clinical and translational research problems, we have been able to demonstrate that TRIAD achieves agile “working interoperability” between distributed data and knowledge sources. Conclusion Informed by our initial verification and validation studies, we believe TRIAD provides an example instance of a lightweight and readily adoptable approach to the use of SOA technologies in the clinical and translational research setting. Furthermore, our initial use cases illustrate the importance and efficacy of enabling “working interoperability” in heterogeneous biomedical environments. PMID:23616879

TRIAD: The Translational Research Informatics and Data Management Grid.

PubMed

Payne, P; Ervin, D; Dhaval, R; Borlawsky, T; Lai, A

2011-01-01

Multi-disciplinary and multi-site biomedical research programs frequently require infrastructures capable of enabling the collection, management, analysis, and dissemination of heterogeneous, multi-dimensional, and distributed data and knowledge collections spanning organizational boundaries. We report on the design and initial deployment of an extensible biomedical informatics platform that is intended to address such requirements. A common approach to distributed data, information, and knowledge management needs in the healthcare and life science settings is the deployment and use of a service-oriented architecture (SOA). Such SOA technologies provide for strongly-typed, semantically annotated, and stateful data and analytical services that can be combined into data and knowledge integration and analysis "pipelines." Using this overall design pattern, we have implemented and evaluated an extensible SOA platform for clinical and translational science applications known as the Translational Research Informatics and Data-management grid (TRIAD). TRIAD is a derivative and extension of the caGrid middleware and has an emphasis on supporting agile "working interoperability" between data, information, and knowledge resources. Based upon initial verification and validation studies conducted in the context of a collection of driving clinical and translational research problems, we have been able to demonstrate that TRIAD achieves agile "working interoperability" between distributed data and knowledge sources. Informed by our initial verification and validation studies, we believe TRIAD provides an example instance of a lightweight and readily adoptable approach to the use of SOA technologies in the clinical and translational research setting. Furthermore, our initial use cases illustrate the importance and efficacy of enabling "working interoperability" in heterogeneous biomedical environments.

Discovering Collaboration and Knowledge Management Practices for the Future Digital Factory

NASA Astrophysics Data System (ADS)

Flores, Myrna; Vera, Tomas; Tucci, Christopher

Recently there has been an explosion of new technologies and tools such as wikis, blogs, tags, Facebook, among many others, that are commonly identified under Web 2.0 and which promise a new digital business ecosystem fed by formal/informal and internal/external relationships and interactions. Although Web 2.0 is very promising to enable such collective knowledge creation, technology by itself is not the only ingredient. It is also required to define the right strategy, governance, culture, processes, training, incentives among others, before implementing such innovative open spaces for collaboration and knowledge sharing. Therefore, the objective of this paper is to present a Knowledge Management (KM) Framework and a Maturity Model developed by a CEMEX and EPFL collaborative research project to discover the AS-IS collaboration practices in CEMEX before the implementation of the SMARTBRICKS Web 2.0 prototype for Business Process Management (BPM), currently under development by the Intelligent Manufacturing Systems (IMS) Swiss Digital Factory (DiFac) project.

Integration of Problem-based Learning and Innovative Technology Into a Self-Care Course

PubMed Central

2013-01-01

Objective. To assess the integration of problem-based learning and technology into a self-care course. Design. Problem-based learning (PBL) activities were developed and implemented in place of lectures in a self-care course. Students used technology, such as computer-generated virtual patients and iPads, during the PBL sessions. Assessments. Students’ scores on post-case quizzes were higher than on pre-case quizzes used to assess baseline knowledge. Student satisfaction with problem-based learning and the use of technology in the course remained consistent throughout the semester. Conclusion. Integrating problem-based learning and technology into a self-care course enabled students to become active learners. PMID:23966730

Semantically enabling pharmacogenomic data for the realization of personalized medicine

PubMed Central

Samwald, Matthias; Coulet, Adrien; Huerga, Iker; Powers, Robert L; Luciano, Joanne S; Freimuth, Robert R; Whipple, Frederick; Pichler, Elgar; Prud’hommeaux, Eric; Dumontier, Michel; Marshall, M Scott

2014-01-01

Understanding how each individual’s genetics and physiology influences pharmaceutical response is crucial to the realization of personalized medicine and the discovery and validation of pharmacogenomic biomarkers is key to its success. However, integration of genotype and phenotype knowledge in medical information systems remains a critical challenge. The inability to easily and accurately integrate the results of biomolecular studies with patients’ medical records and clinical reports prevents us from realizing the full potential of pharmacogenomic knowledge for both drug development and clinical practice. Herein, we describe approaches using Semantic Web technologies, in which pharmacogenomic knowledge relevant to drug development and medical decision support is represented in such a way that it can be efficiently accessed both by software and human experts. We suggest that this approach increases the utility of data, and that such computational technologies will become an essential part of personalized medicine, alongside diagnostics and pharmaceutical products. PMID:22256869

A Hitchhiker’s Guide to Mechanobiology

PubMed Central

Eyckmans, Jeroen; Boudou, Thomas; Yu, Xiang; Chen, Christopher S.

2011-01-01

More than a century ago, it was proposed that mechanical forces could drive tissue formation. However, only recently with the advent of enabling biophysical and molecular technologies are we beginning to understand how individual cells transduce mechanical force into biochemical signals. In turn, this knowledge of mechanotransduction at the cellular level is beginning to clarify the role of mechanics in patterning processes during embryonic development. In this perspective, we will discuss current mechanotransduction paradigms, along with the technologies that have shaped the field of mechanobiology. PMID:21763607

Unraveling the development of scientific literacy: Domain-specific inquiry support in a system of cognitive and social interactions

NASA Astrophysics Data System (ADS)

Tabak, Iris Ellen

The goal of this dissertation was to study how to harness technological tools in service of establishing a climate of inquiry in science classrooms. The research is a design experiment drawing on sociocultural and cognitive theory. As part of the BGuILE project, I developed software to support observational research of natural selection, and a complementary high school unit on evolution. Focusing on urban schools, I employed interpretive methods to examine learning as it unfolds in the classroom. I present design principles for realizing a climate of inquiry in technology-infused classrooms. This research contributes to technology design, teaching practice and educational and cognitive research. My pedagogical approach, Domain-Specific Strategic Support (DSSS), helps students analyze and synthesize primary data by making experts' considerations of content knowledge explicit. Students query data by constructing questions from a selection of comparison and variable types that are privileged in the domain. Students organize their data according to evidence categories that comprise a natural selection argument. I compared the inquiry process of contrastive cases: an honor group, a regular group and a lower track group. DSSS enabled students at different achievement levels to set up systematic comparisons, and construct empirically-based explanations. Prior knowledge and inquiry experience influenced spontaneous strategy use. Teacher guidance compensated for lack of experience, and enabled regular level students to employ strategies as frequently as honor students. I extend earlier research by proposing a taxonomy of both general and domain-specific reflective inquiry strategies. I argue that software, teacher and curriculum work in concert to sustain a climate of inquiry. Teachers help realize the potential that technological tools invite. Teachers reinforce software supports by encouraging students utilize technological tools, and by modeling their use. They also establish classroom norms that reflect scientific values. Discussions at the computer allow teachers to provide just-in-time guidance on inquiry actions. Whole class discussions afford sharing insights across groups, and relating finding to normative knowledge. Pretest to posttest improvements in both conceptual and strategic knowledge suggest that DSSS helps reconcile the tension that can exist between content and process goals in inquiry settings.

Online communities of practice and their role in educational development: a systematic appraisal.

PubMed

Swift, Lynn

2014-04-01

Practice teachers and academics have a role in developing knowledge and promoting evidence-based practice with their students in a supportive and creative learning environment. Recent advances in technology are enabling communities of practice' (CoPs) to be developed online and may present a valuable opportunity to form greater connections between educators. To explore this idea, the author conducted a systematic appraisal of published evidence relating to the impact of using an online CoP (OCoP) to develop knowledge among healthcare educators. Three academic databases were targeted for articles and the search retrieved nine articles that were analysed for quality. The findings identified that an OCoP offers a 'polycontextual' environment that can enhance knowledge development, strengthen social ties and build social capital. Communities that support tacit knowledge development, information sharing and problem solving are most valued and existing information and communication technology (ICT) tools can be used to promote usability and accessibility. Recognising the value of tacit knowledge and using ICT for educational development within workload hours will require a shift in cultural thinking at both an individual and organisational level.

The Biophysics of Infection.

PubMed

Leake, Mark C

2016-01-01

Our understanding of the processes involved in infection has grown enormously in the past decade due in part to emerging methods of biophysics. This new insight has been enabled through advances in interdisciplinary experimental technologies and theoretical methods at the cutting-edge interface of the life and physical sciences. For example, this has involved several state-of-the-art biophysical tools used in conjunction with molecular and cell biology approaches, which enable investigation of infection in living cells. There are also new, emerging interfacial science tools which enable significant improvements to the resolution of quantitative measurements both in space and time. These include single-molecule biophysics methods and super-resolution microscopy approaches. These new technological tools in particular have underpinned much new understanding of dynamic processes of infection at a molecular length scale. Also, there are many valuable advances made recently in theoretical approaches of biophysics which enable advances in predictive modelling to generate new understanding of infection. Here, I discuss these advances, and take stock on our knowledge of the biophysics of infection and discuss where future advances may lead.

The National Network forTechnology Entrepreneurship and Commercialization (N2TEC): Bringing New Technologies to Market

NASA Astrophysics Data System (ADS)

Allen, Kathleen

2003-03-01

N2TEC, the National Network for Technology Entrepreneurship and Commercialization, is a National Science Foundation "Partnerships for Innovation" initiative designed to raise the level of innovation and technology commercialization in colleges, universities, and communities across the nation. N2TEC is creating a network of people and institutions, and a set of technology tools that will facilitate the pooling of resources and knowledge and enable faculty and students to share those resources and collaborate without regard to geographic boundaries. N2TEC will become the backbone by which educational institutions across the nation can move their technologies into new venture startups. The ultimate goal is to create new wealth and strengthen local, regional and national economies.

The interaction of representation and reasoning

PubMed Central

Bundy, Alan

2013-01-01

Automated reasoning is an enabling technology for many applications of informatics. These applications include verifying that a computer program meets its specification; enabling a robot to form a plan to achieve a task and answering questions by combining information from diverse sources, e.g. on the Internet, etc. How is automated reasoning possible? Firstly, knowledge of a domain must be stored in a computer, usually in the form of logical formulae. This knowledge might, for instance, have been entered manually, retrieved from the Internet or perceived in the environment via sensors, such as cameras. Secondly, rules of inference are applied to old knowledge to derive new knowledge. Automated reasoning techniques have been adapted from logic, a branch of mathematics that was originally designed to formalize the reasoning of humans, especially mathematicians. My special interest is in the way that representation and reasoning interact. Successful reasoning is dependent on appropriate representation of both knowledge and successful methods of reasoning. Failures of reasoning can suggest changes of representation. This process of representational change can also be automated. We will illustrate the automation of representational change by drawing on recent work in my research group. PMID:24062623

Space Technologies for Enhancing the Resilience and Sustainability of Indigenous Reindeer Husbandry in the Russian Arctic

NASA Technical Reports Server (NTRS)

Maynard, Nancy G.; Yurchak, Boris S.; Sleptsov, Yuri A.; Turi, Johan Mathis; Mathlesen, Svein D.

2005-01-01

To adapt successfully to the major changes - climate, environment, economic, social and industrial - which have taken place across the Arctic. in recent years, indigenous communities such as reindeer herders must become increasingly empowered with the best available technologies to add to their storehouse of traditional knowledge. Remotely-sensed data and observations are providing increased capabilities for monitoring, risk mapping, and surveillance of parameters critical to the characterization of pasture quality and migratory routes, such as vegetation distribution, snow cover, infrastructure development, and pasture damages due to fires. This paper describes a series of remote sensing capabilities, which are useful to reindeer husbandry, and gives the results of the first year of a project, "Reindeer Mapper", which is a remote sensing and GIs-based system to bring together space technologies with indigenous knowledge for sustainable reindeer husbandry in the Russian Arctic. In this project, reindeer herders and scientists are joining together to utilize technologies to create a system for collecting and sharing space-based and indigenous knowledge in the Russian Arctic. The "Reindeer Mapper" system will help make technologies more readily available to the herder community for observing, data collection and analysis, monitoring, sharing, communications, and dissemination of information - to be integrated with traditional, local knowledge. This paper describes some of the technologies which comprise the system including an intranet system to enable to the team members to work together and share information electronically, remote sensing data for monitoring environmental parameters important to reindeer husbandry (e.g., SAR, Landsat, AVHRR, MODIS), indigenous knowledge about important environmental parameters, acquisition of ground- based measurements, and the integration of all useful data sets for more informed decision-making.

Rocket University at KSC

NASA Technical Reports Server (NTRS)

Sullivan, Steven J.

2014-01-01

"Rocket University" is an exciting new initiative at Kennedy Space Center led by NASA's Engineering and Technology Directorate. This hands-on experience has been established to develop, refine & maintain targeted flight engineering skills to enable the Agency and KSC strategic goals. Through "RocketU", KSC is developing a nimble, rapid flight engineering life cycle systems knowledge base. Ongoing activities in RocketU develop and test new technologies and potential customer systems through small scale vehicles, build and maintain flight experience through balloon and small-scale rocket missions, and enable a revolving fresh perspective of engineers with hands on expertise back into the large scale NASA programs, providing a more experienced multi-disciplined set of systems engineers. This overview will define the Program, highlight aspects of the training curriculum, and identify recent accomplishments and activities.

Multi-dimensional knowledge translation: enabling health informatics capacity audits using patient journey models.

PubMed

Catley, Christina; McGregor, Carolyn; Percival, Jennifer; Curry, Joanne; James, Andrew

2008-01-01

This paper presents a multi-dimensional approach to knowledge translation, enabling results obtained from a survey evaluating the uptake of Information Technology within Neonatal Intensive Care Units to be translated into knowledge, in the form of health informatics capacity audits. Survey data, having multiple roles, patient care scenarios, levels, and hospitals, is translated using a structured data modeling approach, into patient journey models. The data model is defined such that users can develop queries to generate patient journey models based on a pre-defined Patient Journey Model architecture (PaJMa). PaJMa models are then analyzed to build capacity audits. Capacity audits offer a sophisticated view of health informatics usage, providing not only details of what IT solutions a hospital utilizes, but also answering the questions: when, how and why, by determining when the IT solutions are integrated into the patient journey, how they support the patient information flow, and why they improve the patient journey.

Neurotechnology for monitoring and restoring sensory, motor, and autonomic functions

NASA Astrophysics Data System (ADS)

Wu, Pae C.; Knaack, Gretchen; Weber, Douglas J.

2016-05-01

The rapid and exponential advances in micro- and nanotechnologies over the last decade have enabled devices that communicate directly with the nervous system to measure and influence neural activity. Many of the earliest implementations focused on restoration of sensory and motor function, but as knowledge of physiology advances and technology continues to improve in accuracy, precision, and safety, new modes of engaging with the autonomic system herald an era of health restoration that may augment or replace many conventional pharmacotherapies. DARPA's Biological Technologies Office is continuing to advance neurotechnology by investing in neural interface technologies that are effective, reliable, and safe for long-term use in humans. DARPA's Hand Proprioception and Touch Interfaces (HAPTIX) program is creating a fully implantable system that interfaces with peripheral nerves in amputees to enable natural control and sensation for prosthetic limbs. Beyond standard electrode implementations, the Electrical Prescriptions (ElectRx) program is investing in innovative approaches to minimally or non-invasively interface with the peripheral nervous system using novel magnetic, optogenetic, and ultrasound-based technologies. These new mechanisms of interrogating and stimulating the peripheral nervous system are driving towards unparalleled spatiotemporal resolution, specificity and targeting, and noninvasiveness to enable chronic, human-use applications in closed-loop neuromodulation for the treatment of disease.

Enabling a New Planning and Scheduling Paradigm

NASA Technical Reports Server (NTRS)

Jaap, John; Davis, Elizabeth

2004-01-01

The Flight Projects Directorate at NASA's Marshall Space Flight Center is developing a new planning and scheduling environment and a new scheduling algorithm to enable a paradigm shift in planning and scheduling concepts. Over the past 33 years Marshall has developed and evolved a paradigm for generating payload timelines for Skylab, Spacelab, various other Shuttle payloads, and the International Space Station. The current paradigm starts by collecting the requirements, called "tasks models," from the scientists and technologists for the tasks that they want to be done. Because of shortcomings in the current modeling schema, some requirements are entered as notes. Next a cadre with knowledge of vehicle and hardware modifies these models to encompass and be compatible with the hardware model; again, notes are added when the modeling schema does not provide a better way to represent the requirements. Finally, another cadre further modifies the models to be compatible with the scheduling engine. This last cadre also submits the models to the scheduling engine or builds the timeline manually to accommodate requirements that are expressed in notes. A future paradigm would provide a scheduling engine that accepts separate science models and hardware models. The modeling schema would have the capability to represent all the requirements without resorting to notes. Furthermore, the scheduling engine would not require that the models be modified to account for the capabilities (limitations) of the scheduling engine. The enabling technology under development at Marshall has three major components. (1) A new modeling schema allows expressing all the requirements of the tasks without resorting to notes or awkward contrivances. The chosen modeling schema is both maximally expressive and easy to use. It utilizes graphics methods to show hierarchies of task constraints and networks of temporal relationships. (2) A new scheduling algorithm automatically schedules the models without the intervention of a scheduling expert. The algorithm is tuned for the constraint hierarchies and the complex temporal relationships provided by the modeling schema. It has an extensive search algorithm which can exploit timing flexibilities and constraint and relationship options. (3) A web-based architecture allows multiple remote users to simultaneously model science and technology requirements and other users to model vehicle and hardware characteristics. The architecture allows the users to submit scheduling requests directly to the scheduling engine and immediately see the results. These three components are integrated so that science and technology experts with no knowledge of the vehicle or hardware subsystems and no knowledge of the internal workings of the scheduling engine have the ability to build and submit scheduling requests and see the results. The immediate feedback will hone the users' modeling skills and ultimately enable them to produce the desired timeline. This paper summarizes the three components of the enabling technology and describes how this technology would make a new paradigm possible.

Debating Life on Mars: The Knowledge Integration Environment (KIE) in Varied School Settings.

ERIC Educational Resources Information Center

Shear, Linda

Technology-enabled learning environments are beginning to come of age. Tools and frameworks are now available that have been shown to improve learning and are being deployed more widely in varied school settings. Teachers are now faced with the formidable challenge of integrating these promising new environments with the everyday context in which…

Opening the door to innovation.

PubMed

Schuurman, Janine; Graus, Yvo F; Labrijn, Aran F; Ruuls, Sigrid; Parren, Paul W H I

2014-01-01

Open innovation is the new buzz, with initiatives popping up left and right. Here, we give a personal perspective on a very successful, knowledge-driven innovation initiated in an academia- industry alliance, which culminated in technology platforms that enable the generation of therapeutic antibodies with novel properties. To start, we provide a general background on open innovation in the drug development field.

E-Mentoring at a Distance: An Approach to Support Professional Development in Workplaces

ERIC Educational Resources Information Center

Tanis, Hasan; Barker, Ian

2017-01-01

The rapid growth of technology has had a significant effect on educational activities. As a result of this growth, a shift has taken place from a behaviorist teaching style to a constructivist perspective which enables adult learners to build up knowledge collaboratively. Mentoring, a valuable tool within the constructivism approach, can offer a…

2005 21st National Logistics Conference and Exhibition

DTIC Science & Technology

2005-03-03

Logistics Transformation ... Achieving Knowledge-Enabled Logistics Panel: Sustained Materiel Readiness, by Mr. David V. Pauling , Assistant Deputy Under... John Erb, Deputy Director for Strategic Logistics, The Joint Staff Desired Operational Logistics Capabilities, by COL Dave Mintus, USA, NORAD-US...KBR Government Operations Session 8: Operational Logistics Information Technology Government Chair: Mr. John J. Erb, Deputy Director for Strategic

The Use of Virtual Reality Tools in the Reading-Language Arts Classroom

ERIC Educational Resources Information Center

Pilgrim, J. Michael; Pilgrim, Jodi

2016-01-01

This article presents virtual reality as a tool for classroom literacy instruction. Building on the traditional use of images as a way to scaffold prior knowledge, we extend this idea to share ways virtual reality enables experiential learning through field trip-like experiences. The use of technology tools such Google Street view, Google…

Moving Ahead for Academic Excellence through International Journal Publication

ERIC Educational Resources Information Center

Jusoff, Kamaruzaman; Abdullah, Zaini; Samah, Siti Akmar Abu

2009-01-01

One of the several roles partaken by academicians in institutions of higher education in Malaysia is the quest in publication. The objective of establishing a critical mass of researchers and knowledge corpus that enable Malaysia to reach the global standard of technology creation and innovation as clearly stated in the newly launched October 2007…

How peer-review constrains cognition: on the frontline in the knowledge sector.

PubMed

Cowley, Stephen J

2015-01-01

Peer-review is neither reliable, fair, nor a valid basis for predicting 'impact': as quality control, peer-review is not fit for purpose. Endorsing the consensus, I offer a reframing: while a normative social process, peer-review also shapes the writing of a scientific paper. In so far as 'cognition' describes enabling conditions for flexible behavior, the practices of peer-review thus constrain knowledge-making. To pursue cognitive functions of peer-review, however, manuscripts must be seen as 'symbolizations', replicable patterns that use technologically enabled activity. On this bio-cognitive view, peer-review constrains knowledge-making by writers, editors, reviewers. Authors are prompted to recursively re-aggregate symbolizations to present what are deemed acceptable knowledge claims. How, then, can recursive re-embodiment be explored? In illustration, I sketch how the paper's own content came to be re-aggregated: agonistic review drove reformatting of argument structure, changes in rhetorical ploys and careful choice of wordings. For this reason, the paper's knowledge-claims can be traced to human activity that occurs in distributed cognitive systems. Peer-review is on the frontline in the knowledge sector in that it delimits what can count as knowing. Its systemic nature is therefore crucial to not only discipline-centered 'real' science but also its 'post-academic' counterparts.

Autonomy enables new science missions

NASA Astrophysics Data System (ADS)

Doyle, Richard J.; Gor, Victoria; Man, Guy K.; Stolorz, Paul E.; Chapman, Clark; Merline, William J.; Stern, Alan

1997-01-01

The challenge of space flight in NASA's future is to enable smaller, more frequent and intensive space exploration at much lower total cost without substantially decreasing mission reliability, capability, or the scientific return on investment. The most effective way to achieve this goal is to build intelligent capabilities into the spacecraft themselves. Our technological vision for meeting the challenge of returning quality science through limited communication bandwidth will actually put scientists in a more direct link with the spacecraft than they have enjoyed to date. Technologies such as pattern recognition and machine learning can place a part of the scientist's awareness onboard the spacecraft to prioritize downlink or to autonomously trigger time-critical follow-up observations-particularly important in flyby missions-without ground interaction. Onboard knowledge discovery methods can be used to include candidate discoveries in each downlink for scientists' scrutiny. Such capabilities will allow scientists to quickly reprioritize missions in a much more intimate and efficient manner than is possible today. Ultimately, new classes of exploration missions will be enabled.

Preparing for Human Exploration

NASA Technical Reports Server (NTRS)

Drake, Bret G.; Joosten, B. Kent

1998-01-01

NASA's Human Exploration and Development of Space (HEDS) Enterprise is defining architectures and requirements for human exploration that radically reduce the costs of such missions through the use of advanced technologies, commercial partnerships and innovative systems strategies. In addition, the HEDS Enterprise is collaborating with the Space Science Enterprise to acquire needed early knowledge about Mars and to demonstrate critical technologies via robotic missions. This paper provides an overview of the technological challenges facing NASA as it prepares for human exploration. Emphasis is placed on identifying the key technologies including those which will provide the most return in terms of reducing total mission cost and/or reducing potential risk to the mission crew. Top-level requirements are provided for those critical enabling technology options currently under consideration.

Virtual Observatories, Data Mining, and Astroinformatics

NASA Astrophysics Data System (ADS)

Borne, Kirk

The historical, current, and future trends in knowledge discovery from data in astronomy are presented here. The story begins with a brief history of data gathering and data organization. A description of the development ofnew information science technologies for astronomical discovery is then presented. Among these are e-Science and the virtual observatory, with its data discovery, access, display, and integration protocols; astroinformatics and data mining for exploratory data analysis, information extraction, and knowledge discovery from distributed data collections; new sky surveys' databases, including rich multivariate observational parameter sets for large numbers of objects; and the emerging discipline of data-oriented astronomical research, called astroinformatics. Astroinformatics is described as the fourth paradigm of astronomical research, following the three traditional research methodologies: observation, theory, and computation/modeling. Astroinformatics research areas include machine learning, data mining, visualization, statistics, semantic science, and scientific data management.Each of these areas is now an active research discipline, with significantscience-enabling applications in astronomy. Research challenges and sample research scenarios are presented in these areas, in addition to sample algorithms for data-oriented research. These information science technologies enable scientific knowledge discovery from the increasingly large and complex data collections in astronomy. The education and training of the modern astronomy student must consequently include skill development in these areas, whose practitioners have traditionally been limited to applied mathematicians, computer scientists, and statisticians. Modern astronomical researchers must cross these traditional discipline boundaries, thereby borrowing the best of breed methodologies from multiple disciplines. In the era of large sky surveys and numerous large telescopes, the potential for astronomical discovery is equally large, and so the data-oriented research methods, algorithms, and techniques that are presented here will enable the greatest discovery potential from the ever-growing data and information resources in astronomy.

Optical network democratization.

PubMed

Nejabati, Reza; Peng, Shuping; Simeonidou, Dimitra

2016-03-06

The current Internet infrastructure is not able to support independent evolution and innovation at physical and network layer functionalities, protocols and services, while at same time supporting the increasing bandwidth demands of evolving and heterogeneous applications. This paper addresses this problem by proposing a completely democratized optical network infrastructure. It introduces the novel concepts of the optical white box and bare metal optical switch as key technology enablers for democratizing optical networks. These are programmable optical switches whose hardware is loosely connected internally and is completely separated from their control software. To alleviate their complexity, a multi-dimensional abstraction mechanism using software-defined network technology is proposed. It creates a universal model of the proposed switches without exposing their technological details. It also enables a conventional network programmer to develop network applications for control of the optical network without specific technical knowledge of the physical layer. Furthermore, a novel optical network virtualization mechanism is proposed, enabling the composition and operation of multiple coexisting and application-specific virtual optical networks sharing the same physical infrastructure. Finally, the optical white box and the abstraction mechanism are experimentally evaluated, while the virtualization mechanism is evaluated with simulation. © 2016 The Author(s).

The new world of discovery, invention, and innovation: convergence of knowledge, technology, and society

NASA Astrophysics Data System (ADS)

Roco, Mihail C.; Bainbridge, William S.

2013-09-01

Convergence of knowledge and technology for the benefit of society (CKTS) is the core opportunity for progress in the twenty-first century. CKTS is defined as the escalating and transformative interactions among seemingly different disciplines, technologies, communities, and domains of human activity to achieve mutual compatibility, synergism, and integration, and through this process to create added value and branch out to meet shared goals. Convergence has been progressing by stages over the past several decades, beginning with nanotechnology for the material world, followed by convergence of nanotechnology, biotechnology, information, and cognitive science (NBIC) for emerging technologies. CKTS is the third level of convergence. It suggests a general process to advance creativity, innovation, and societal progress based on five general purpose principles: (1) the interdependence of all components of nature and society, (2) decision analysis for research, development, and applications based on dynamic system-logic deduction, (3) enhancement of creativity and innovation through evolutionary processes of convergence that combines existing principles and divergence that generates new ones, (4) the utility of higher-level cross-domain languages to generate new solutions and support transfer of new knowledge, and (5) the value of vision-inspired basic research embodied in grand challenges. CKTS is a general purpose approach in knowledge society. It allows society to answer questions and resolve problems that isolated capabilities cannot, as well as to create new competencies, knowledge, and technologies on this basis. Possible solutions are outlined for key societal challenges in the next decade, including support for foundational emerging technologies NBIC to penetrate essential platforms of human activity and create new industries and jobs, improve lifelong wellness and human potential, achieve personalized and integrated healthcare and education, and secure a sustainable quality of life for all. This paper provides a 10-year "NBIC2" vision within a longer-term framework for converging technology and human progress outlined in a previous study of unifying principles across "NBIC" fields that began with nanotechnology, biotechnology, information technology, and technologies based on and enabling cognitive science (Roco and Bainbridge, Converging technologies for improving human performance: nanotechnology, biotechnology, information technology and cognitive sciences, 2003).

FY10 Engineering Innovations, Research and Technology Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, M A; Aceves, S M; Paulson, C N

This report summarizes key research, development, and technology advancements in Lawrence Livermore National Laboratory's Engineering Directorate for FY2010. These efforts exemplify Engineering's nearly 60-year history of developing and applying the technology innovations needed for the Laboratory's national security missions, and embody Engineering's mission to ''Enable program success today and ensure the Laboratory's vitality tomorrow.'' Leading off the report is a section featuring compelling engineering innovations. These innovations range from advanced hydrogen storage that enables clean vehicles, to new nuclear material detection technologies, to a landmine detection system using ultra-wideband ground-penetrating radar. Many have been recognized with R&D Magazine's prestigious R&Dmore » 100 Award; all are examples of the forward-looking application of innovative engineering to pressing national problems and challenging customer requirements. Engineering's capability development strategy includes both fundamental research and technology development. Engineering research creates the competencies of the future where discovery-class groundwork is required. Our technology development (or reduction to practice) efforts enable many of the research breakthroughs across the Laboratory to translate from the world of basic research to the national security missions of the Laboratory. This portfolio approach produces new and advanced technological capabilities, and is a unique component of the value proposition of the Lawrence Livermore Laboratory. The balance of the report highlights this work in research and technology, organized into thematic technical areas: Computational Engineering; Micro/Nano-Devices and Structures; Measurement Technologies; Engineering Systems for Knowledge Discovery; and Energy Manipulation. Our investments in these areas serve not only known programmatic requirements of today and tomorrow, but also anticipate the breakthrough engineering innovations that will be needed in the future.« less

Requirements and Solutions for Personalized Health Systems.

PubMed

Blobel, Bernd; Ruotsalainen, Pekka; Lopez, Diego M; Oemig, Frank

2017-01-01

Organizational, methodological and technological paradigm changes enable a precise, personalized, predictive, preventive and participative approach to health and social services supported by multiple actors from different domains at diverse level of knowledge and skills. Interoperability has to advance beyond Information and Communication Technologies (ICT) concerns, including the real world business domains and their processes, but also the individual context of all actors involved. The paper introduces and compares personalized health definitions, summarizes requirements and principles for pHealth systems, and considers intelligent interoperability. It addresses knowledge representation and harmonization, decision intelligence, and usability as crucial issues in pHealth. On this basis, a system-theoretical, ontology-based, policy-driven reference architecture model for open and intelligent pHealth ecosystems and its transformation into an appropriate ICT design and implementation is proposed.

An Ontology for Telemedicine Systems Resiliency to Technological Context Variations in Pervasive Healthcare

PubMed Central

Bults, Richard G. A.; Van Sinderen, Marten J.; Widya, Ing; Hermens, Hermie J.

2015-01-01

Clinical data are crucial for any medical case to study and understand a patient’s condition and to give the patient the best possible treatment. Pervasive healthcare systems apply information and communication technology to enable the usage of ubiquitous clinical data by authorized medical persons. However, quality of clinical data in these applications is, to a large extent, determined by the technological context of the patient. A technological context is characterized by potential technological disruptions that affect optimal functioning of technological resources. The clinical data based on input from these technological resources can therefore have quality degradations. If these degradations are not noticed, the use of this clinical data can lead to wrong treatment decisions, which potentially puts the patient’s safety at risk. This paper presents an ontology that specifies the relation among technological context, quality of clinical data, and patient treatment. The presented ontology provides a formal way to represent the knowledge to specify the effect of technological context variations in the clinical data quality and the impact of the clinical data quality on a patient’s treatment. Accordingly, this ontology is the foundation for a quality of data framework that enables the development of telemedicine systems that are capable of adapting the treatment when the quality of the clinical data degrades, and thus guaranteeing patients’ safety even when technological context varies. PMID:27170903

Romans to Mars

NASA Technical Reports Server (NTRS)

Bents, D. J.

1990-01-01

The key role played by technology advancement with respect to the anticipated era of discovery and exploration (in space) is illustrated: how bold new initiatives may or may not be enabled. A truly enabling technology not only renders the proposed missions technically feasible, but also makes them viable economically; that is, low enough in cost (relative to the economy supporting them) that urgent national need is not required for justification, low enough in cost that high risk can be programmatically tolerated. A fictional parallel is drawn to the Roman Empire of the second century A.D., shown to have possessed by that time the necessary knowledge, motivation, means, and technical capability of mounting, through the use of innovative mission planning, an initiative similar to Columbus' voyage. They failed to do so because they lacked the advanced technology necessary to make it an acceptable proposition economically. Speculation, based on the historical perspective, is made on the outcome of contemporary plans for future exploration showing how they will be subjected to the same historical forces, within limits imposed by the state of technology development, that shaped the timing of that previous era of discovery and exploration.

Bridging the Gap Between Earth Science Open Data Producers and Consumers Using a Standards based approach

NASA Astrophysics Data System (ADS)

Stephan, E.; Sivaraman, C.

2016-12-01

The Web brought together science communities creating collaborative opportunities that were previously unimaginable. This was due to the novel ways technology enabled users to share information that would otherwise not be available. This means that data and software that previously could not be discovered without direct contact with data or software creators can now be downloaded with the click of a mouse button, and the same products can now outlive the lifespan of their research projects. While in many ways these technological advancements provide benefit to collaborating scientists, a critical producer-consumer knowledge gap is created when collaborating scientists rely solely on web sites, web browsers, or similar technology to exchange services, software, and data. Without some best practices and common approaches from Web publishers, collaborating scientific consumers have no inherent way to trust the results or other products being shared, producers have no way to convey their scientific credibility, and publishers risk obscurity where data is hidden in the deep Web. By leveraging recommendations from the W3C Data Activity, scientific communities can adopt best practices for data publication enabling consumers to explore, reuse, reproduce, and contribute their knowledge about the data. This talk will discuss the application of W3C Data on the Web Best Practices in support of published earth science data and feature the Data Usage Vocabulary.

Developing accessible cyberinfrastructure-enabled knowledge communities in the national disability community: theory, practice, and policy.

PubMed

Myhill, William N; Cogburn, Derrick L; Samant, Deepti; Addom, Benjamin Kwasi; Blanck, Peter

2008-01-01

Since publication of the Atkins Commission report in 2003, the national scientific community has placed significant emphasis on developing cyberinfrastructure-enabled knowledge communities, which are designed to facilitate enhanced efficiency and collaboration in geographically distributed networks of researchers. This article suggests that the new cyberinfrastructure movement may not fully benefit those participants with disabilities, unless closer attention is paid to legal mandates and universal design principles. Many technology-enhanced learning communities provide geographically distributed collaboration opportunities that expand the inclusion of diverse peoples and help close the digital divide. However, to date, most collaboratory efforts have not emphasized the need for access among people with disabilities nor meeting minimum standards for technological accessibility. To address these concerns, this article reports on two pilot collaboratory studies that explore the role advanced information, communication, and collaboration technologies play in enhancing geographically distributed collaboration among specific research and applied networks within the national disability community. Universal design principles inform the design of the collaboratory and its use and our efforts to ensure access for all. Data for this article come from Web-based surveys, interviews, observations, computer logs, and detailed, mixed-methods accessibility testing. Emerging results suggest that with deliberate and systematic efforts, cyberinfrastructure can be more accessible and generate benefits among persons with disabilities. The authors provide lessons learned and recommendations for future research, policy, law, and practice.

Need to Knowledge (NtK) Model: an evidence-based framework for generating technological innovations with socio-economic impacts.

PubMed

Flagg, Jennifer L; Lane, Joseph P; Lockett, Michelle M

2013-02-15

Traditional government policies suggest that upstream investment in scientific research is necessary and sufficient to generate technological innovations. The expected downstream beneficial socio-economic impacts are presumed to occur through non-government market mechanisms. However, there is little quantitative evidence for such a direct and formulaic relationship between public investment at the input end and marketplace benefits at the impact end. Instead, the literature demonstrates that the technological innovation process involves a complex interaction between multiple sectors, methods, and stakeholders. The authors theorize that accomplishing the full process of technological innovation in a deliberate and systematic manner requires an operational-level model encompassing three underlying methods, each designed to generate knowledge outputs in different states: scientific research generates conceptual discoveries; engineering development generates prototype inventions; and industrial production generates commercial innovations. Given the critical roles of engineering and business, the entire innovation process should continuously consider the practical requirements and constraints of the commercial marketplace.The Need to Knowledge (NtK) Model encompasses the activities required to successfully generate innovations, along with associated strategies for effectively communicating knowledge outputs in all three states to the various stakeholders involved. It is intentionally grounded in evidence drawn from academic analysis to facilitate objective and quantitative scrutiny, and industry best practices to enable practical application. The Need to Knowledge (NtK) Model offers a practical, market-oriented approach that avoids the gaps, constraints and inefficiencies inherent in undirected activities and disconnected sectors. The NtK Model is a means to realizing increased returns on public investments in those science and technology programs expressly intended to generate beneficial socio-economic impacts.

Need to Knowledge (NtK) Model: an evidence-based framework for generating technological innovations with socio-economic impacts

PubMed Central

2013-01-01

Background Traditional government policies suggest that upstream investment in scientific research is necessary and sufficient to generate technological innovations. The expected downstream beneficial socio-economic impacts are presumed to occur through non-government market mechanisms. However, there is little quantitative evidence for such a direct and formulaic relationship between public investment at the input end and marketplace benefits at the impact end. Instead, the literature demonstrates that the technological innovation process involves a complex interaction between multiple sectors, methods, and stakeholders. Discussion The authors theorize that accomplishing the full process of technological innovation in a deliberate and systematic manner requires an operational-level model encompassing three underlying methods, each designed to generate knowledge outputs in different states: scientific research generates conceptual discoveries; engineering development generates prototype inventions; and industrial production generates commercial innovations. Given the critical roles of engineering and business, the entire innovation process should continuously consider the practical requirements and constraints of the commercial marketplace. The Need to Knowledge (NtK) Model encompasses the activities required to successfully generate innovations, along with associated strategies for effectively communicating knowledge outputs in all three states to the various stakeholders involved. It is intentionally grounded in evidence drawn from academic analysis to facilitate objective and quantitative scrutiny, and industry best practices to enable practical application. Summary The Need to Knowledge (NtK) Model offers a practical, market-oriented approach that avoids the gaps, constraints and inefficiencies inherent in undirected activities and disconnected sectors. The NtK Model is a means to realizing increased returns on public investments in those science and technology programs expressly intended to generate beneficial socio-economic impacts. PMID:23414369

Reducing the stair step effect of layer manufactured surfaces by ball burnishing

NASA Astrophysics Data System (ADS)

Hiegemann, Lars; Agarwal, Chiranshu; Weddeling, Christian; Tekkaya, A. Erman

2016-10-01

The layer technology enables fast and flexible additive manufacturing of forming tools. The disadvantages of this system is the formation of stair steps in the range of tool radii. Within this work a new method to smooth this stair steps by ball burnishing is introduced. This includes studies on the general feasibility of the process and the determination of the influence of the rolling parameters. The investigations are carried out experimentally and numerically. Ultimately, the gained knowledge is applied to finish a deep drawing tool which is manufactured by layer technology.

SBIR Advanced Technologies in Aviation and Air Transportation System 2016

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.; Kaszeta, Richard W.; Gold, Calman; Corke, Thomas C.; McGowan, Ryan; Matlis, Eric; Eichenlaub, Jesse; Davis, Joshua T.; Shah, Parthiv N.

2017-01-01

This report is intended to provide a broad knowledge of various topics associated with NASA's Aeronautics Research Mission Directorate (ARMD), with particular interest on the NASA SBIR contracts awarded from 2011-2012 executed by small companies. The content of this report focuses on the high-quality, cutting-edge research that will lead to revolutionary concepts, technologies, and capabilities that enable radical change to both the airspace system and the aircraft that fly within it, facilitating a safer, more environmentally friendly, and more efficient air transportation system.

Interactive Classification Technology

NASA Technical Reports Server (NTRS)

deBessonet, Cary

2000-01-01

The investigators upgraded a knowledge representation language called SL (Symbolic Language) and an automated reasoning system called SMS (Symbolic Manipulation System) to enable the more effective use of the technologies in automated reasoning and interactive classification systems. The overall goals of the project were: 1) the enhancement of the representation language SL to accommodate a wider range of meaning; 2) the development of a default inference scheme to operate over SL notation as it is encoded; and 3) the development of an interpreter for SL that would handle representations of some basic cognitive acts and perspectives.

Fate of Trace Metals in Anaerobic Digestion.

PubMed

Fermoso, F G; van Hullebusch, E D; Guibaud, G; Collins, G; Svensson, B H; Carliell-Marquet, C; Vink, J P M; Esposito, G; Frunzo, L

2015-01-01

A challenging, and largely uncharted, area of research in the field of anaerobic digestion science and technology is in understanding the roles of trace metals in enabling biogas production. This is a major knowledge gap and a multifaceted problem involving metal chemistry; physical interactions of metal and solids; microbiology; and technology optimization. Moreover, the fate of trace metals, and the chemical speciation and transport of trace metals in environments--often agricultural lands receiving discharge waters from anaerobic digestion processes--simultaneously represents challenges for environmental protection and opportunities to close process loops in anaerobic digestion.

On Your Mark, Get Set, Wait! Are Your Teacher Candidates Prepared to Embed Assistive Technology in Teaching and Learning?

ERIC Educational Resources Information Center

Nelson, Betty

2006-01-01

Linda Darling-Hammond's simplistic, yet profound observation addresses the basis of reform in teacher education today. Our challenge is to develop the knowledge, disposition, and teaching performance or skills of initial and advanced teacher candidates to enable them to deliver the foundations of education necessary to meet the critical…

Beyond the electronic textbook model: software techniques to make on-line educational content dynamic.

PubMed

Frank, M S; Dreyer, K

2001-06-01

We describe a working software technology that enables educators to incorporate their expertise and teaching style into highly interactive and Socratic educational material for distribution on the world wide web. A graphically oriented interactive authoring system was developed to enable the computer novice to create and store within a database his or her domain expertise in the form of electronic knowledge. The authoring system supports and facilitates the input and integration of several types of content, including free-form, stylized text, miniature and full-sized images, audio, and interactive questions with immediate feedback. The system enables the choreography and sequencing of these entities for display within a web page as well as the sequencing of entire web pages within a case-based or thematic presentation. Images or segments of text can be hyperlinked with point-and-click to other entities such as adjunctive web pages, audio, or other images, cases, or electronic chapters. Miniature (thumbnail) images are automatically linked to their full-sized counterparts. The authoring system contains a graphically oriented word processor, an image editor, and capabilities to automatically invoke and use external image-editing software such as Photoshop. The system works in both local area network (LAN) and internet-centric environments. An internal metalanguage (invisible to the author but stored with the content) was invented to represent the choreographic directives that specify the interactive delivery of the content on the world wide web. A database schema was developed to objectify and store both this electronic knowledge and its associated choreographic metalanguage. A database engine was combined with page-rendering algorithms in order to retrieve content from the database and deliver it on the web in a Socratic style, assess the recipient's current fund of knowledge, and provide immediate feedback, thus stimulating in-person interaction with a human expert. This technology enables the educator to choreograph a stylized, interactive delivery of his or her message using multimedia components assembled in virtually any order, spanning any number of web pages for a given case or theme. An educator can thus exercise precise influence on specific learning objectives, embody his or her personal teaching style within the content, and ultimately enhance its educational impact. The described technology amplifies the efforts of the educator and provides a more dynamic and enriching learning environment for web-based education.

Automated optical assembly

NASA Astrophysics Data System (ADS)

Bala, John L.

1995-08-01

Automation and polymer science represent fundamental new technologies which can be directed toward realizing the goal of establishing a domestic, world-class, commercial optics business. Use of innovative optical designs using precision polymer optics will enable the US to play a vital role in the next generation of commercial optical products. The increased cost savings inherent in the utilization of optical-grade polymers outweighs almost every advantage of using glass for high volume situations. Optical designers must gain experience with combined refractive/diffractive designs and broaden their knowledge base regarding polymer technology beyond a cursory intellectual exercise. Implementation of a fully automated assembly system, combined with utilization of polymer optics, constitutes the type of integrated manufacturing process which will enable the US to successfully compete with the low-cost labor employed in the Far East, as well as to produce an equivalent product.

Perspectives on the Role and Synergies of Architecture and Social and Built Environment in Enabling Active Healthy Aging

PubMed Central

Rabnett, Richard; Tziraki, Chariklia

2016-01-01

Research has demonstrated that enabling societal and physical infrastructure and personal accommodations enhance healthy and active aging throughout the lifespan. Yet, there is a paucity of research on how to bring together the various disciplines involved in a multidomain synergistic collaboration to create new living environments for aging. This paper aims to explore the key domains of skills and knowledge that need to be considered for a conceptual prototype of an enabling educational process and environments where healthcare professionals, architects, planners, and entrepreneurs may establish a shared theoretical and experiential knowledge base, vocabulary, and implementation strategies, for the creation of the next generation of living communities of active healthy adults, for persons with disabilities and chronic disease conditions. We focus on synergistic, paradigmatic, simple, and practical issues that can be easily upscaled through market mechanisms. This practical and physically concrete approach may also become linked with more elaborate neuroscientific and technologically sophisticated interventions. We examine the domains of knowledge to be included in establishing a learning model that focuses on the still-understudied impact of the benefits toward active and healthy aging, where architects, urban planners, clinicians, and healthcare facility managers are educated toward a synergistic approach at the operational level. PMID:27656295

Semantics-enabled service discovery framework in the SIMDAT pharma grid.

PubMed

Qu, Cangtao; Zimmermann, Falk; Kumpf, Kai; Kamuzinzi, Richard; Ledent, Valérie; Herzog, Robert

2008-03-01

We present the design and implementation of a semantics-enabled service discovery framework in the data Grids for process and product development using numerical simulation and knowledge discovery (SIMDAT) Pharma Grid, an industry-oriented Grid environment for integrating thousands of Grid-enabled biological data services and analysis services. The framework consists of three major components: the Web ontology language (OWL)-description logic (DL)-based biological domain ontology, OWL Web service ontology (OWL-S)-based service annotation, and semantic matchmaker based on the ontology reasoning. Built upon the framework, workflow technologies are extensively exploited in the SIMDAT to assist biologists in (semi)automatically performing in silico experiments. We present a typical usage scenario through the case study of a biological workflow: IXodus.

Towards a standardised representation of a knowledge base for adverse drug event prevention.

PubMed

Koutkias, Vassilis; Lazou, Katerina; de Clercq, Paul; Maglaveras, Nicos

2011-01-01

Knowledge representation is an important part of knowledge engineering activities that is crucial for enabling knowledge sharing and reuse. In this regard, standardised formalisms and technologies play a significant role. Especially for the medical domain, where knowledge may be tacit, not articulated and highly diverse, the development and adoption of standardised knowledge representations is highly challenging and of outmost importance to achieve knowledge interoperability. To this end, this paper presents a research effort towards the standardised representation of a Knowledge Base (KB) encapsulating rule-based signals and procedures for Adverse Drug Event (ADE) prevention. The KB constitutes an integral part of Clinical Decision Support Systems (CDSSs) to be used at the point of care. The paper highlights the requirements at the domain of discourse with respect to knowledge representation, according to which GELLO (an HL7 and ANSI standard) has been adopted. Results of our prototype implementation are presented along with the advantages and the limitations introduced by the employed approach.

Earth Science Enterprise Technology Strategy

NASA Technical Reports Server (NTRS)

1999-01-01

NASA's Earth Science Enterprise (ESE) is dedicated to understanding the total Earth system and the effects of natural and human-induced changes on the global environment. The goals of ESE are: (1) Expand scientific knowledge of the Earth system using NASA's unique vantage points of space, aircraft, and in situ platforms; (2) Disseminate information about the Earth system; and (3) Enable the productive use of ESE science and technology in the public and private sectors. ESE has embraced the NASA Administrator's better, faster, cheaper paradigm for Earth observing missions. We are committed to launch the next generation of Earth Observing System (EOS) missions at a substantially lower cost than the EOS first series. Strategic investment in advanced instrument, spacecraft, and information system technologies is essential to accomplishing ESE's research goals in the coming decades. Advanced technology will play a major role in shaping the ESE fundamental and applied research program of the future. ESE has established an Earth science technology development program with the following objectives: (1) To accomplish ESE space-based and land-based program elements effectively and efficiently; and (2) To enable ESE's fundamental and applied research programs goals as stated in the NASA Strategic Plan.

MENTOR: an enabler for interoperable intelligent systems

NASA Astrophysics Data System (ADS)

Sarraipa, João; Jardim-Goncalves, Ricardo; Steiger-Garcao, Adolfo

2010-07-01

A community with knowledge organisation based on ontologies will enable an increase in the computational intelligence of its information systems. However, due to the worldwide diversity of communities, a high number of knowledge representation elements, which are not semantically coincident, have appeared representing the same segment of reality, becoming a barrier to business communications. Even if a domain community uses the same kind of technologies in its information systems, such as ontologies, it doesn't solve its semantics differences. In order to solve this interoperability problem, a solution is to use a reference ontology as an intermediary in the communications between the community enterprises and the outside, while allowing the enterprises to keep their own ontology and semantics unchanged internally. This work proposes MENTOR, a methodology to support the development of a common reference ontology for a group of organisations sharing the same business domain. This methodology is based on the mediator ontology (MO) concept, which assists the semantic transformations among each enterprise's ontology and the referential one. The MO enables each organisation to keep its own terminology, glossary and ontological structures, while providing seamless communication and interaction with the others.

Harnessing: Technologies for Sustainable Reindeer Husbandry in the Arctic

NASA Technical Reports Server (NTRS)

Maynard, Nancy G.; Yurchak, Boris; Turi, Johan Mathis; Mathiesen, Svein

2004-01-01

To accelerate the development of sustainable reindeer husbandry under the lead of indigenous reindeer herders, it is critical to empower reindeer herders with the best available technologies and to promote a new kind of science where traditional knowledge is fully integrated into the scientific management of the natural environment in the Arctic. This is particularly true given the dramatic environmental, climatic, economic, social and industrial changes, which have taken place across the Arctic in recent years, all of which have had serious impacts on the reindeer herding communities of the North. The Anar Declaration, adopted by the 2d World Reindeer Herders Congress (WRHC), in Inari, Finland, June 2001drew guidelines for the development of a sustainable reindeer husbandry based on reindeer peoples values and goals. The declaration calls for the reindeer herding peoples to be given the possibilities to develop and influence the management of the reindeer industry and its natural environment because of their knowledge and traditional practices. At the same time, Arctic scientists from many institutions and governments are carrying out increasingly highly technical reindeer related research activities. It is important that the technologies and results of these activities be more commonly co-produced with the reindeer herder community and/or made more readily available to the reindeer peoples for comparison with traditional knowledge for improved herd management. This paper describes a project in which reindeer herders and scientists are utilizing technologies to create a system for collecting and sharing knowledge. The project, Reindeer Mapper, is creating an information management and knowledge sharing system, which will help make technologies more readily available to the herder community for observing, data collection and analysis, monitoring, sharing, communications, and dissemination of information - to be integrated with traditional, local knowledge. The paper describes some of the technologies which comprise the system including an intranet system to enable the team members to work together and share information electronically, remote sensing data for monitoring environmental parameters important to reindeer husbandry (e.g. SAR, Landsat), acquisition of ground-based measurements, and the GIS-based information management and knowledge sharing system.

Decision Analysis Methods Used to Make Appropriate Investments in Human Exploration Capabilities and Technologies

NASA Technical Reports Server (NTRS)

Williams-Byrd, Julie; Arney, Dale C.; Hay, Jason; Reeves, John D.; Craig, Douglas

2016-01-01

NASA is transforming human spaceflight. The Agency is shifting from an exploration-based program with human activities in low Earth orbit (LEO) and targeted robotic missions in deep space to a more sustainable and integrated pioneering approach. Through pioneering, NASA seeks to address national goals to develop the capacity for people to work, learn, operate, live, and thrive safely beyond Earth for extended periods of time. However, pioneering space involves daunting technical challenges of transportation, maintaining health, and enabling crew productivity for long durations in remote, hostile, and alien environments. Prudent investments in capability and technology developments, based on mission need, are critical for enabling a campaign of human exploration missions. There are a wide variety of capabilities and technologies that could enable these missions, so it is a major challenge for NASA's Human Exploration and Operations Mission Directorate (HEOMD) to make knowledgeable portfolio decisions. It is critical for this pioneering initiative that these investment decisions are informed with a prioritization process that is robust and defensible. It is NASA's role to invest in targeted technologies and capabilities that would enable exploration missions even though specific requirements have not been identified. To inform these investments decisions, NASA's HEOMD has supported a variety of analysis activities that prioritize capabilities and technologies. These activities are often based on input from subject matter experts within the NASA community who understand the technical challenges of enabling human exploration missions. This paper will review a variety of processes and methods that NASA has used to prioritize and rank capabilities and technologies applicable to human space exploration. The paper will show the similarities in the various processes and showcase instances were customer specified priorities force modifications to the process. Specifically, this paper will describe the processes that the NASA Langley Research Center (LaRC) Technology Assessment and Integration Team (TAIT) has used for several years and how those processes have been customized to meet customer needs while staying robust and defensible. This paper will show how HEOMD uses these analyses results to assist with making informed portfolio investment decisions. The paper will also highlight which human exploration capabilities and technologies typically rank high regardless of the specific design reference mission. The paper will conclude by describing future capability and technology ranking activities that will continue o leverage subject matter experts (SME) input while also incorporating more model-based analysis.

How peer-review constrains cognition: on the frontline in the knowledge sector

PubMed Central

Cowley, Stephen J.

2015-01-01

Peer-review is neither reliable, fair, nor a valid basis for predicting ‘impact’: as quality control, peer-review is not fit for purpose. Endorsing the consensus, I offer a reframing: while a normative social process, peer-review also shapes the writing of a scientific paper. In so far as ‘cognition’ describes enabling conditions for flexible behavior, the practices of peer-review thus constrain knowledge-making. To pursue cognitive functions of peer-review, however, manuscripts must be seen as ‘symbolizations’, replicable patterns that use technologically enabled activity. On this bio-cognitive view, peer-review constrains knowledge-making by writers, editors, reviewers. Authors are prompted to recursively re-aggregate symbolizations to present what are deemed acceptable knowledge claims. How, then, can recursive re-embodiment be explored? In illustration, I sketch how the paper’s own content came to be re-aggregated: agonistic review drove reformatting of argument structure, changes in rhetorical ploys and careful choice of wordings. For this reason, the paper’s knowledge-claims can be traced to human activity that occurs in distributed cognitive systems. Peer-review is on the frontline in the knowledge sector in that it delimits what can count as knowing. Its systemic nature is therefore crucial to not only discipline-centered ‘real’ science but also its ‘post-academic’ counterparts. PMID:26579064

Inkjet printing for biosensor fabrication: combining chemistry and technology for advanced manufacturing.

PubMed

Li, Jia; Rossignol, Fabrice; Macdonald, Joanne

2015-06-21

Inkjet printing is emerging at the forefront of biosensor fabrication technologies. Parallel advances in both ink chemistry and printers have led to a biosensor manufacturing approach that is simple, rapid, flexible, high resolution, low cost, efficient for mass production, and extends the capabilities of devices beyond other manufacturing technologies. Here we review for the first time the factors behind successful inkjet biosensor fabrication, including printers, inks, patterning methods, and matrix types. We discuss technical considerations that are important when moving beyond theoretical knowledge to practical implementation. We also highlight significant advances in biosensor functionality that have been realised through inkjet printing. Finally, we consider future possibilities for biosensors enabled by this novel combination of chemistry and technology.

Distributed collaborative environments for virtual capability-based planning

NASA Astrophysics Data System (ADS)

McQuay, William K.

2003-09-01

Distributed collaboration is an emerging technology that will significantly change how decisions are made in the 21st century. Collaboration involves two or more geographically dispersed individuals working together to share and exchange data, information, knowledge, and actions. The marriage of information, collaboration, and simulation technologies provides the decision maker with a collaborative virtual environment for planning and decision support. This paper reviews research that is focusing on the applying open standards agent-based framework with integrated modeling and simulation to a new Air Force initiative in capability-based planning and the ability to implement it in a distributed virtual environment. Virtual Capability Planning effort will provide decision-quality knowledge for Air Force resource allocation and investment planning including examining proposed capabilities and cost of alternative approaches, the impact of technologies, identification of primary risk drivers, and creation of executable acquisition strategies. The transformed Air Force business processes are enabled by iterative use of constructive and virtual modeling, simulation, and analysis together with information technology. These tools are applied collaboratively via a technical framework by all the affected stakeholders - warfighter, laboratory, product center, logistics center, test center, and primary contractor.

Opening Public Administration: Exploring Open Innovation Archetypes and Business Model Impacts

NASA Astrophysics Data System (ADS)

Feller, Joseph; Finnegan, Patrick; Nilsson, Olof

This work-in-progress paper presents an exploration of a network of Swedish municipal authorities. Within this network, we have observed a move from isolated innovation to leveraging inflows and outflows of knowledge in a manner characteristic of the open innovation paradigm. This paper presents a characterization of these knowledge exchanges using an existing framework of open innovation archetypes, as well as an initial description of the business model impacts of this innovation approach on the participant municipalities, and the enabling role of information technology. The paper concludes by drawing preliminary conclusions and outlining ongoing research.

Transforming Dental Technology Education: Skills, Knowledge, and Curricular Reform.

PubMed

Bobich, Anita M; Mitchell, Betty L

2017-09-01

Dental technology is one of the core allied dental health professions supporting the practice of dentistry. By definition, it is the art, science, and technologies that enable the design and fabrication of dental prostheses and/or corrective devices to restore natural teeth and supporting structures to fulfill a patient's physiological and esthetic needs. Dental technology educational programs are faced with serious challenges, including rapid changes in technology, inadequate funding for educational programs, and the need to develop curricula that reflect current industry needs. Better communications between dental technologists and practitioners are needed to gain greater recognition of the contribution that technologists make to patient health. Amid these challenges, the technology workforce is dedicated to providing patients with the best possible restorative dental prostheses. This article was written as part of the project "Advancing Dental Education in the 21 st Century."

Teaching science to 8th graders by engaging them in a design and technology activity: A case study

NASA Astrophysics Data System (ADS)

Sidawi, Mai M.

This study described how students can apply science concepts to a Design and Technology task. It also examined whether the students could transfer their scientific knowledge to their design of technology. The study was conducted at an urban school in Philadelphia where a sample of 36 eighth grade students were taught a science unit, Energy, Machines, and Motion, and engaged in a technology design task that was chosen based on the scientific content of the unit. Two approaches of relating teaching science to technological design were observed and described. Through the first approach, the students were given technology lessons in addition to their science lessons. This was to provide them with the technological knowledge that they needed in designing technology such as learning about the design process, selection of appropriate materials, and selection of appropriate tools and how to use them. Also, the students were taught the social skills that will enable them to develop an effective collaborative relationship with their peers such as conflict-management and brainstorming. Through the second approach, the students were taught the science unit and then at the end of the unit the students were given the design task as an assessment of their scientific knowledge. The students' experience of designing technology for each approach was described. The study was conducted using multiple tools and instruments such as observation, videotaping, interviews, and testing. The students were also given the survey PATT-USA to measure their attitude toward technology. The study showed that the students' learning of science was impacted by their weak prerequisite knowledge in science, their poor verbal and written communication skills and their style as dependent learners. Also, the study showed the great impact of the school and classroom cultures on the participation of the students in a Design and Technology activity. The students in this study showed great resistant to participating in a Design and Technology activity. The study linked that to the culture of the classroom where the technology period was considered by the students a period of "free time" to be spent mainly on the computer, playing educational games or engaged in short term, non-demanding projects.

Understanding pressurized metered dose inhaler performance.

PubMed

Ivey, James W; Vehring, Reinhard; Finlay, Warren H

2015-06-01

Deepening the current understanding of the factors governing the performance of the pressurized metered dose inhaler (pMDI) has the potential to benefit patients by providing improved drugs for current indications as well as by enabling new areas of therapy. Although a great deal of work has been conducted to this end, our knowledge of the physical mechanisms that drive pMDI performance remains incomplete. This review focuses on research into the influence of device and formulation variables on pMDI performance metrics. Literature in the areas of dose metering, atomization and aerosol evolution and deposition is covered, with an emphasis on studies of a more fundamental nature. Simple models which may be of use to those developing pMDI products are summarized. Although researchers have had good success utilizing an empirically developed knowledge base to predict pMDI performance, such knowledge may not be applicable when pursuing innovations in device or formulation technology. Developing a better understanding of the underlying mechanisms is a worthwhile investment for those working to enable the next generation of pMDI products.

Students Teach Pupils Environmental Issues and Renewable Energy

NASA Astrophysics Data System (ADS)

Friman, H.; Banner, I.; Tuchin, B. S.; Einav, Y.

2018-05-01

Technological advances and accessibility to information on the internet have opened a new channel of pupils that are being taught by students throughout the country. Students, full of motivation and a will to learn and teach, have understood that this way is good for them – enabling them to profit from a side job and take advantage of the knowledge they have accumulated in their degree. Holon Institute of Technology (“HIT”) developed a new program at the Faculty of Electrical Engineering. The Renewable Energy program gives the students technical and practical aspects of energy use (technology and methodology of the study) and energy efficiency. The program also deals with minimizing the environmental impacts of energy use, as well as with energy economy and environmental policy. The entrance of students to the field of teaching pupils while still in their studies brings many advantages, such as: fresh knowledge, motivation to teach, and innovative, out of the ordinary methods that arouse interest in the pupils and intrigue them.

Enriching Arizona's Knowledge Economy: Creating the Research Connections, Attention, and Talent Arizona Needs to Compete. Proposition 301 Investments at Arizona State University, FY 2002-FY 2005

ERIC Educational Resources Information Center

Heffernon, Rick

2006-01-01

This report presents results tracked by the CAT Measures, a 21st century assessment tool for enabling policymakers to monitor "en route" performance of their public investments in science and technology research. Developed by Morrison Institute for Public Policy at Arizona State University, the CAT Measures analyze growth supporting…

Effect of 5E Learning Model on Academic Achievement, Attitude and Science Process Skills: Meta-Analysis Study

ERIC Educational Resources Information Center

Cakir, Nevin Kozcu

2017-01-01

Today, with the development of science and technology and its rapid progress, the importance attached to science education has increased. This increase in interest has led to the development of the methods, techniques, and approaches that enable the students to be active, question and construct knowledge. The 5E learning model is one of them, and…

Role of Social Knowledge Networking technology in facilitating meaningful use of Electronic Health Record medication reconciliation.

PubMed

Rangachari, Pavani

2016-06-01

Despite the federal policy impetus towards EHR Medication Reconciliation, hospital adherence has lagged for one chief reason; low physician engagement, which in turn emanates from lack of consensus in regard to which physician is responsible for managing a patient's medication list, and the importance of medication reconciliation as a tool for improving patient safety and quality of care. The Technology-in-Practice (TIP) framework stresses the role of human action in enacting structures of technology use or "technologies-in-practice." Applying the TIP framework to the EHR Medication Reconciliation context, helps frame the problem as one of low physician engagement in performing EHR Medication Reconciliation, translating to limited-use-EHR-in-practice. Concurrently, the problem suggests a hierarchical network structure, reflecting limited communication among hospital administrators and clinical providers on the importance of EHR Medication Reconciliation in improving patient safety. Integrating the TIP literature with the more recent knowledge-in-Practice (KIP) literature suggests that EHR-in-practice could be transformed from "limited use" to "meaningful use" through the use of Social Knowledge Networking (SKN) Technology to create new social network structures, and enable engagement, learning, and practice change. Correspondingly, the objectives of this paper are to: 1) Conduct a narrative review of the literature on "technology use," to understand how technologies-in-practice may be transformed from limited use to meaningful use; 2) Conduct a narrative review of the literature on "organizational change implementation," to understand how changes in technology use could be successfully implemented and sustained in a healthcare organizational context; and 3) Apply lessons learned from the narrative literature reviews to identify strategies for the meaningful use and successful implementation of EHR Medication Reconciliation technology.

Distal technologies and type 1 diabetes management.

PubMed

Duke, Danny C; Barry, Samantha; Wagner, David V; Speight, Jane; Choudhary, Pratik; Harris, Michael A

2018-02-01

Type 1 diabetes requires intensive self-management to avoid acute and long-term health complications. In the past two decades, substantial advances in technology have enabled more effective and convenient self-management of type 1 diabetes. Although proximal technologies (eg, insulin pumps, continuous glucose monitors, closed-loop and artificial pancreas systems) have been the subject of frequent systematic and narrative reviews, distal technologies have received scant attention. Distal technologies refer to electronic systems designed to provide a service remotely and include heterogeneous systems such as telehealth, mobile health applications, game-based support, social platforms, and patient portals. In this Review, we summarise the empirical literature to provide current information about the effectiveness of available distal technologies to improve type 1 diabetes management. We also discuss privacy, ethics, and regulatory considerations, issues of global adoption, knowledge gaps in distal technology, and recommendations for future directions. Copyright © 2018 Elsevier Ltd. All rights reserved.

Instantiating informatics in nursing practice for integrated patient centred holistic models of care: a discussion paper.

PubMed

Hussey, Pamela A; Kennedy, Margaret Ann

2016-05-01

A discussion on how informatics knowledge and competencies can enable nursing to instantiate transition to integrated models of care. Costs of traditional models of care are no longer sustainable consequent to the spiralling incidence and costs of chronic illness. The international community looks towards technology-enabled solutions to support a shift towards integrated patient-centred models of care. Discussion paper. A search of the literature was performed dating from 2000-2015 and a purposeful data sample based on relevance to building the discussion was included. The holistic perspective of nursing knowledge can support and advance integrated healthcare models. Informatics skills are key for the profession to play a leadership role in design, implementation and operation of next generation health care. However, evidence suggests that nursing engagement with informatics strategic development for healthcare provision is currently variable. A statistically significant need exists to progress health care towards integrated models of care. Strategic and tactical plans that are robustly pragmatic with nursing insights and expertise are an essential component to achieve effective healthcare provision. To avoid exclusion in the discourse dominated by management and technology experts, nursing leaders must develop and actively promote the advancement of nursing informatics skills. For knowledge in nursing practice to flourish in contemporary health care, nurse leaders will need to incorporate informatics for optimal translation and interpretation. Defined nursing leadership roles informed by informatics are essential to generate concrete solutions sustaining nursing practice in integrated care models. © 2016 John Wiley & Sons Ltd.

FINESSE Spaceward Bound - Teacher Engagement in NASA Science and Exploration Field Research

NASA Technical Reports Server (NTRS)

Jones, A. J. P.; Heldmann, J. L.; Sheely, T.; Karlin, J.; Johnson, S.; Rosemore, A.; Hughes, S.; Nawotniak, S. Kobs; Lim, D. S. S.; Garry, W. B.

2016-01-01

The FINESSE (Field Investigations to Enable Solar System Science and Exploration) team of NASA's Solar System Exploration Research Virtual Institute (SSERVI) is focused on a science and exploration field-based research program aimed at generating strategic knowledge in preparation for the human and robotic exploration of the Moon, Near Earth Asteroids, and the moons of Mars. The FINESSE science program is infused with leading edge exploration concepts since "science enables exploration and exploration enables science." The FINESSE education and public outreach program leverages the team's field investigations and educational partnerships to share the excitement of lunar, Near Earth Asteroid, and martian moon science and exploration locally, nationally, and internationally. The FINESSE education plan is in line with all of NASA's Science Mission Directorate science education objectives, particularly to enable STEM (science, technology, engineering, and mathematics) education and leverage efforts through partnerships.

Appropriation of social media for fostering effective tacit knowledge sharing: developing conceptual model

NASA Astrophysics Data System (ADS)

Amidi, A.; Jabar, M.; Jusoh, Y. Y.; Abdullah, R.

2017-09-01

With the rising popularity of social media in the past few years, several researches ratiocinate that this type of interactive and collaborative technology could be a beneficial tool for the sharing of tacit knowledge. Nevertheless, very few literatures have tackled the subject of how social media could facilitate tacit knowledge sharing among medical practitioners, and what are its contributions in the area. Thus, the factors that drive individuals to share tacit knowledge need to be investigated further and included in literature. Through a systematic literature review, this study proposes seven enabling conditions which could potentially facilitate the sharing of tacit knowledge. TAM was applied as a novelty in this study in investigating the factors influencing knowledge sharing via social media, whilst taking into account the mediation effects of Attitude in social media usage. This study uncovered an important correlation between virtual settings and the conversion of tacit knowledge, which affects organizational members who are not co-located physically but have a crucial need for sharing information.

In the blink of an eye: head mounted displays development within BAE Systems

NASA Astrophysics Data System (ADS)

Cameron, Alex

2015-05-01

There has been an explosion of interest in head worn displays in recent years, particularly for consumer applications with an attendant ramping up of investment into key enabling technologies to provide what is essence a mobile computer display. However, head mounted system have been around for over 40 years and today's consumer products are building on a legacy of knowledge and technology created by companies such as BAE Systems who have been designing and fielding helmet mounted displays (HMD) for a wide range of specialist applications. Although the dominant application area has been military aviation, solutions have been fielded for solider, ground vehicle, simulation, medical, racing car and even subsea navigation applications. What sets these HMDs apart is that they provide the user with accurate conformal information embedded in the users real world view where the information presented is intuitive and easy to use because it overlays the real world and enables them to stay head up, eyes out, - improving their effectiveness, reducing workload and improving safety. Such systems are an enabling technology in the provision of enhanced Situation Awareness (SA) and reducing user workload in high intensity situations. These capabilities are finding much wider application in new types of compact man mounted audio/visual products enabled by the emergence of new families of micro displays, novel optical concepts and ultra-compact low power processing solutions. This paper therefore provides a personal summary of BAE Systems 40 year's journey in developing and fielding Head Mounted systems, their applications.

Generation of surgical pathology report using a 5,000-word speech recognizer.

PubMed

Tischler, A S; Martin, M R

1989-10-01

Pressures to decrease both turnaround time and operating costs simultaneously have placed conflicting demands on traditional forms of medical transcription. The new technology of voice recognition extends the promise of enabling the pathologist or other medical professional to dictate a correct report and have it printed and/or transmitted to a database immediately. The usefulness of voice recognition systems depends on several factors, including ease of use, reliability, speed, and accuracy. These in turn depend on the general underlying design of the systems and inclusion in the systems of a specific knowledge base appropriate for each application. Development of a good knowledge base requires close collaboration between a domain expert and a knowledge engineer with expertise in voice recognition. The authors have recently completed a knowledge base for surgical pathology using the Kurzweil VoiceReport 5,000-word system.

NASA's Advanced Information Systems Technology (AIST) Program: Advanced Concepts and Disruptive Technologies

NASA Astrophysics Data System (ADS)

Little, M. M.; Moe, K.; Komar, G.

2014-12-01

NASA's Earth Science Technology Office (ESTO) manages a wide range of information technology projects under the Advanced Information Systems Technology (AIST) Program. The AIST Program aims to support all phases of NASA's Earth Science program with the goal of enabling new observations and information products, increasing the accessibility and use of Earth observations, and reducing the risk and cost of satellite and ground based information systems. Recent initiatives feature computational technologies to improve information extracted from data streams or model outputs and researchers' tools for Big Data analytics. Data-centric technologies enable research communities to facilitate collaboration and increase the speed with which results are produced and published. In the future NASA anticipates more small satellites (e.g., CubeSats), mobile drones and ground-based in-situ sensors will advance the state-of-the-art regarding how scientific observations are performed, given the flexibility, cost and deployment advantages of new operations technologies. This paper reviews the success of the program and the lessons learned. Infusion of these technologies is challenging and the paper discusses the obstacles and strategies to adoption by the earth science research and application efforts. It also describes alternative perspectives for the future program direction and for realizing the value in the steps to transform observations from sensors to data, to information, and to knowledge, namely: sensor measurement concepts development; data acquisition and management; data product generation; and data exploitation for science and applications.

Adaptive Peircean decision aid project summary assessments.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Senglaub, Michael E.

2007-01-01

This efforts objective was to identify and hybridize a suite of technologies enabling the development of predictive decision aids for use principally in combat environments but also in any complex information terrain. The technologies required included formal concept analysis for knowledge representation and information operations, Peircean reasoning to support hypothesis generation, Mill's's canons to begin defining information operators that support the first two technologies and co-evolutionary game theory to provide the environment/domain to assess predictions from the reasoning engines. The intended application domain is the IED problem because of its inherent evolutionary nature. While a fully functioning integrated algorithm wasmore » not achieved the hybridization and demonstration of the technologies was accomplished and demonstration of utility provided for a number of ancillary queries.« less

Examining the Effect of Enactment of a Geospatial Curriculum on Students' Geospatial Thinking and Reasoning

NASA Astrophysics Data System (ADS)

Bodzin, Alec M.; Fu, Qiong; Kulo, Violet; Peffer, Tamara

2014-08-01

A potential method for teaching geospatial thinking and reasoning (GTR) is through geospatially enabled learning technologies. We developed an energy resources geospatial curriculum that included learning activities with geographic information systems and virtual globes. This study investigated how 13 urban middle school teachers implemented and varied the enactment of the curriculum with their students and investigated which teacher- and student-level factors accounted for students' GTR posttest achievement. Data included biweekly implementation surveys from teachers and energy resources content and GTR pre- and posttest achievement measures from 1,049 students. Students significantly increased both their energy resources content knowledge and their GTR skills related to energy resources at the end of the curriculum enactment. Both multiple regression and hierarchical linear modeling found that students' initial GTR abilities and gain in energy content knowledge were significantly explanatory variables for their geospatial achievement at the end of curriculum enactment, p < .001. Teacher enactment factors, including adherence to implementing the critical components of the curriculum or the number of years the teachers had taught the curriculum, did not have significant effects on students' geospatial posttest achievement. The findings from this study provide support that learning with geospatially enabled learning technologies can support GTR with urban middle-level learners.

Strengthening capacity building in space science research: A developing country perspective on IHY activities

NASA Astrophysics Data System (ADS)

Munyeme, G.

The economic and social impact of science based technologies has become increasingly dominant in modern world The benefits are a result of combined leading-edge science and technology skills which offers opportunities for new innovations Knowledge in basic sciences has become the cornerstone of sustainable economic growth and national prosperity Unfortunately in many developing countries research and education in basic sciences are inadequate to enable science play its full role in national development For this reason most developing countries have not fully benefited from the opportunities provided by modern technologies The lack of human and financial resources is the main reason for slow transfer of scientific knowledge and technologies to developing countries Developing countries therefore need to develop viable research capabilities and knowledge in basic sciences The advert of the International Heliophysical Year IHY may provide opportunities for strengthening capacity in basic science research in developing countries Among the science goals of the IHY is the fostering of international scientific cooperation in the study of heliophysical phenomena This paper will address and provide an in depth discussion on how basic science research can be enhanced in a developing country using the framework of science goals and objectives of IHY It will further highlight the hurdles and experiences of creating in-country training capacity and research capabilities in space science It will be shown that some of these hurdles can be

Knowledge sharing and collaboration in translational research, and the DC-THERA Directory

PubMed Central

Gündel, Michaela; Austyn, Jonathan M.; Cavalieri, Duccio; Scognamiglio, Ciro; Brandizi, Marco

2011-01-01

Biomedical research relies increasingly on large collections of data sets and knowledge whose generation, representation and analysis often require large collaborative and interdisciplinary efforts. This dimension of ‘big data’ research calls for the development of computational tools to manage such a vast amount of data, as well as tools that can improve communication and access to information from collaborating researchers and from the wider community. Whenever research projects have a defined temporal scope, an additional issue of data management arises, namely how the knowledge generated within the project can be made available beyond its boundaries and life-time. DC-THERA is a European ‘Network of Excellence’ (NoE) that spawned a very large collaborative and interdisciplinary research community, focusing on the development of novel immunotherapies derived from fundamental research in dendritic cell immunobiology. In this article we introduce the DC-THERA Directory, which is an information system designed to support knowledge management for this research community and beyond. We present how the use of metadata and Semantic Web technologies can effectively help to organize the knowledge generated by modern collaborative research, how these technologies can enable effective data management solutions during and beyond the project lifecycle, and how resources such as the DC-THERA Directory fit into the larger context of e-science. PMID:21969471

Scientometric and patentometric analyses to determine the knowledge landscape in innovative technologies: The case of 3D bioprinting

PubMed Central

2017-01-01

This research proposes an innovative data model to determine the landscape of emerging technologies. It is based on a competitive technology intelligence methodology that incorporates the assessment of scientific publications and patent analysis production, and is further supported by experts’ feedback. It enables the definition of the growth rate of scientific and technological output in terms of the top countries, institutions and journals producing knowledge within the field as well as the identification of main areas of research and development by analyzing the International Patent Classification codes including keyword clusterization and co-occurrence of patent assignees and patent codes. This model was applied to the evolving domain of 3D bioprinting. Scientific documents from the Scopus and Web of Science databases, along with patents from 27 authorities and 140 countries, were retrieved. In total, 4782 scientific publications and 706 patents were identified from 2000 to mid-2016. The number of scientific documents published and patents in the last five years showed an annual average growth of 20% and 40%, respectively. Results indicate that the most prolific nations and institutions publishing on 3D bioprinting are the USA and China, including the Massachusetts Institute of Technology (USA), Nanyang Technological University (Singapore) and Tsinghua University (China), respectively. Biomaterials and Biofabrication are the predominant journals. The most prolific patenting countries are China and the USA; while Organovo Holdings Inc. (USA) and Tsinghua University (China) are the institutions leading. International Patent Classification codes reveal that most 3D bioprinting inventions intended for medical purposes apply porous or cellular materials or biologically active materials. Knowledge clusters and expert drivers indicate that there is a research focus on tissue engineering including the fabrication of organs, bioinks and new 3D bioprinting systems. Our model offers a guide to researchers to understand the knowledge production of pioneering technologies, in this case 3D bioprinting. PMID:28662187

Scientometric and patentometric analyses to determine the knowledge landscape in innovative technologies: The case of 3D bioprinting.

PubMed

Rodríguez-Salvador, Marisela; Rio-Belver, Rosa María; Garechana-Anacabe, Gaizka

2017-01-01

This research proposes an innovative data model to determine the landscape of emerging technologies. It is based on a competitive technology intelligence methodology that incorporates the assessment of scientific publications and patent analysis production, and is further supported by experts' feedback. It enables the definition of the growth rate of scientific and technological output in terms of the top countries, institutions and journals producing knowledge within the field as well as the identification of main areas of research and development by analyzing the International Patent Classification codes including keyword clusterization and co-occurrence of patent assignees and patent codes. This model was applied to the evolving domain of 3D bioprinting. Scientific documents from the Scopus and Web of Science databases, along with patents from 27 authorities and 140 countries, were retrieved. In total, 4782 scientific publications and 706 patents were identified from 2000 to mid-2016. The number of scientific documents published and patents in the last five years showed an annual average growth of 20% and 40%, respectively. Results indicate that the most prolific nations and institutions publishing on 3D bioprinting are the USA and China, including the Massachusetts Institute of Technology (USA), Nanyang Technological University (Singapore) and Tsinghua University (China), respectively. Biomaterials and Biofabrication are the predominant journals. The most prolific patenting countries are China and the USA; while Organovo Holdings Inc. (USA) and Tsinghua University (China) are the institutions leading. International Patent Classification codes reveal that most 3D bioprinting inventions intended for medical purposes apply porous or cellular materials or biologically active materials. Knowledge clusters and expert drivers indicate that there is a research focus on tissue engineering including the fabrication of organs, bioinks and new 3D bioprinting systems. Our model offers a guide to researchers to understand the knowledge production of pioneering technologies, in this case 3D bioprinting.

Optimize Use of Space Research and Technology for Medical Devices

NASA Technical Reports Server (NTRS)

Minnifield, Nona K.

2012-01-01

systems, and cutting-edge component technologies to conduct a wide range of scientific observations and measurements. These technologies are also considered for practical applications that benefit society in remarkable ways. At NASA Goddard, the technology transfer initiative promotes matching technologies from Earth and space science needs to targeted industry sectors. This requires clear knowledge of industry needs and priorities and social demands. The process entails matching mature technologies where there are known innovation challenges and good opportunities for matching technology needs. This requires creative thinking and takes commitment of time and resources. Additionally, we also look at applications for known hot industry or societal needs. Doing so has given us occasion to host discussions with representatives from industry, academia, government organizations, and societal special interest groups about the application of NASA Goddard technologies for devices used in medical monitoring and detection tools. As a result, partnerships have been established. Innovation transpired when new products were enabled because of NASA Goddard research and technology programs.

Advanced Information Technology Investments at the NASA Earth Science Technology Office

NASA Astrophysics Data System (ADS)

Clune, T.; Seablom, M. S.; Moe, K.

2012-12-01

The NASA Earth Science Technology Office (ESTO) regularly makes investments for nurturing advanced concepts in information technology to enable rapid, low-cost acquisition, processing and visualization of Earth science data in support of future NASA missions and climate change research. In 2012, the National Research Council published a mid-term assessment of the 2007 decadal survey for future spacemissions supporting Earth science and applications [1]. The report stated, "Earth sciences have advanced significantly because of existing observational capabilities and the fruit of past investments, along with advances in data and information systems, computer science, and enabling technologies." The report found that NASA had responded favorably and aggressively to the decadal survey and noted the role of the recent ESTO solicitation for information systems technologies that partnered with the NASA Applied Sciences Program to support the transition into operations. NASA's future missions are key stakeholders for the ESTO technology investments. Also driving these investments is the need for the Agency to properly address questions regarding the prediction, adaptation, and eventual mitigation of climate change. The Earth Science Division has championed interdisciplinary research, recognizing that the Earth must be studied as a complete system in order toaddress key science questions [2]. Information technology investments in the low-mid technology readiness level (TRL) range play a key role in meeting these challenges. ESTO's Advanced Information Systems Technology (AIST) program invests in higher risk / higher reward technologies that solve the most challenging problems of the information processing chain. This includes the space segment, where the information pipeline begins, to the end user, where knowledge is ultimatelyadvanced. The objectives of the program are to reduce the risk, cost, size, and development time of Earth Science space-based and ground-based systems, increase the accessibility and utility of science data, and to enable new observation measurements and information products. We will discuss the ESTO investment strategy for information technology development, the methods used to assess stakeholder needs and technology advancements, and technology partnerships to enhance the infusion for the resulting technology. We also describe specific investments and their potential impact on enabling NASA missions and scientific discovery. [1] "Earth Science and Applications from Space: A Midterm Assessment of NASA's Implementation of the Decadal Survey", 2012: National Academies Press, http://www.nap.edu/catalog.php?record_id=13405 [2] "Responding to the Challenge of Climate and Environmental Change: NASA's Plan for a Climate-Centric Architecture for Earth Observations and Applications from Space", 2010: NASA Tech Memo, http://science.nasa.gov/media/medialibrary/2010/07/01/Climate_Architecture_Final.pdf

Knowledge and institutional requirements to promote land degradation neutrality in drylands - An analysis of the outcomes of the 3rd UNCCD scientific conference

NASA Astrophysics Data System (ADS)

Akhtar-Schuster, Mariam; Safriel, Uriel; Abraham, Elena; de Vente, Joris; Essahli, Wafa; Escadafal, Richard; Stringer, Lindsay

2015-04-01

Achieving land degradation neutrality (LDN) through sustainable land management (SLM) targets the maintenance or restoration of the productivity of land, and therefore has to include decision-makers, knowledge generators and knowledge holders at the different relevant geographic scales. In order to enhance the implementation of the Convention, the Conference of the Parties (COP) of the United Nations Convention to Combat Desertification therefore decided that each future session of its Committee on Science and Technology (CST) would be organized in a predominantly scientific and technical conference-style format. This contribution will outline the major outcomes of UNCCD's 3rd scientific conference that will be held in Cancún, Mexico, from 9 to 12 March 2015, on addressing desertification, land degradation and drought issues (DLDD) for poverty reduction and sustainable development. The conference follows an exceptional new round table conference format that will allow the various stakeholders to discuss scientific as well as the contribution of traditional knowledge and practices in combating land degradation. This format should provide two-way communication and enable deeper insight into the availability and contribution of all forms of knowledge for achieving LDN through the assessment of: • the vulnerability of lands to DLDD and climate change and the adaptive capacities of socio-ecosystems; • best examples of adapted, knowledge-based practices and technologies; • monitoring and assessment methods to evaluate the effectiveness of adaptation practices and technologies. The outcomes of UNCCD's 3rd scientific conference will serve as a basis for discussing: • contributions of science to diagnose the status of land; • research gaps that need to be addressed to achieve LDN for poverty reduction; • additional institutional requirements to optimally bridge knowledge generation, knowledge maintenance and knowledge implementation at the science-policy interface.

'Ethos' Enabling Organisational Knowledge Creation

NASA Astrophysics Data System (ADS)

Matsudaira, Yoshito

This paper examines knowledge creation in relation to improvements on the production line in the manufacturing department of Nissan Motor Company and aims to clarify embodied knowledge observed in the actions of organisational members who enable knowledge creation will be clarified. For that purpose, this study adopts an approach that adds a first, second, and third-person's viewpoint to the theory of knowledge creation. Embodied knowledge, observed in the actions of organisational members who enable knowledge creation, is the continued practice of 'ethos' (in Greek) founded in Nissan Production Way as an ethical basis. Ethos is knowledge (intangible) assets for knowledge creating companies. Substantiated analysis classifies ethos into three categories: the individual, team and organisation. This indicates the precise actions of the organisational members in each category during the knowledge creation process. This research will be successful in its role of showing the indispensability of ethos - the new concept of knowledge assets, which enables knowledge creation -for future knowledge-based management in the knowledge society.

Training the rivers and exploring the coasts. Knowledge evolution in the Netherlands in two engineering fields between 1800 and 1940

NASA Astrophysics Data System (ADS)

Toussaint, Bert

In this paper, the author wants to explore the knowledge development in two crucial fields, river management and coast management in the 19th century and first decades of the 20th century. Were there similar characteristics in this development? Which types of knowledge can be distinguished? Who were the principal actors in these processes? Did the knowledge evolution have a Dutch stamp or a rather international flavour? To structure the analysis, the author uses the concept of technology regime, a set of technical rules which shapes the know-how of engineers, their design rules and research processes. The analysis shows that the knowledge development of river management and coastal management followed different evolution paths between 1800 and 1940. In the field of river management, a substantial amount of mathematical and physical theories had been gradually developed since the end of the 17th century. After 1850, the regularization approach met gradually a widespread support. Empirical data, design rules, theoretical knowledge and engineering pivoted around the regularization approach, and a technology regime around this approach emerged. The regularization regime further developed in the 20th century, and handbooks were increasingly shaped by mathematical and physical reasoning and formulas. On the other hand, coastal management was until the 1880s a rather marginal activity. Coastal engineering was an extremely complex and multidimensional field of knowledge which no engineer was able to grasp. The foundation of a Dutch weather institute was a first important step towards a more theoretical approach. The Zuiderzee works (starting in 1925) gave probably the most important stimuli to scientific coastal research. It was also a main factor in setting up scientific institutes by Rijkswaterstaat. So from the 1920s, Rijkswaterstaat became a major producer of scientific knowledge, not only in tidal modelling but also in coastal research. Due to a multidisciplinary knowledge network, coastal research transformed from a marginal to a first-rank scientific field, and this transformation enabled Rijkswaterstaat to set a much higher level of ambition in coastal management. The 1953 flood and the Deltaworks marked a new era. New design rules for sea dykes and river levees, based on a revolutionary statistical risk approach were determined, and design rules for the Deltaworks estuary closures were developed, being enabled by the development of hydraulic research.

Informatics, evidence-based care, and research; implications for national policy: a report of an American Medical Informatics Association health policy conference.

PubMed

Bloomrosen, Meryl; Detmer, Don E

2010-01-01

There is an increased level of activity in the biomedical and health informatics world (e-prescribing, electronic health records, personal health records) that, in the near future, will yield a wealth of available data that we can exploit meaningfully to strengthen knowledge building and evidence creation, and ultimately improve clinical and preventive care. The American Medical Informatics Association (AMIA) 2008 Health Policy Conference was convened to focus and propel discussions about informatics-enabled evidence-based care, clinical research, and knowledge management. Conference participants explored the potential of informatics tools and technologies to improve the evidence base on which providers and patients can draw to diagnose and treat health problems. The paper presents a model of an evidence continuum that is dynamic, collaborative, and powered by health informatics technologies. The conference's findings are described, and recommendations on terminology harmonization, facilitation of the evidence continuum in a "wired" world, development and dissemination of clinical practice guidelines and other knowledge support strategies, and the role of diverse stakeholders in the generation and adoption of evidence are presented.

Mobile computing device as tools for college student education: a case on flashcards application

NASA Astrophysics Data System (ADS)

Kang, Congying

2012-04-01

Traditionally, college students always use flash cards as a tool to remember massive knowledge, such as nomenclature, structures, and reactions in chemistry. Educational and information technology have enabled flashcards viewed on computers, like Slides and PowerPoint, works as tunnels of drilling and feedback for the learners. The current generation of students is more capable of information technology and mobile computing devices. For example, they use their Mobile phones much more intensively everyday day. Trends of using Mobile phone as an educational tool is analyzed and a educational technology initiative is proposed, which use Mobile phone flash cards applications to help students learn biology and chemistry. Experiments show that users responded positively to these mobile flash cards.

Use of encapsulated bacteriophages to enhance farm to fork food safety.

PubMed

Hussain, Malik A; Liu, Huan; Wang, Qi; Zhong, Fang; Guo, Qian; Balamurugan, Sampathkumar

2017-09-02

Bacteriophages have been successfully applied to control the growth of pathogens in foods and to reduce the colonization and shedding of pathogens by food animals. They are set to play a dominant role in food safety in the future. However, many food-processing operations and the microenvironments in food animals' guts inactivate phages and reduce their infectivity. Encapsulation technologies have been used successfully to protect phages against extreme environments, and have been shown to preserve their activity and enable their release in targeted environments. A number of encapsulation technologies have shown potential for use with bacteriophages. This review discusses the current state of knowledge about the use of encapsulation technologies with bacteriophages to control pathogens in foods and food animals.

Towards a comprehensive framework for reuse: A reuse-enabling software evolution environment

NASA Technical Reports Server (NTRS)

Basili, V. R.; Rombach, H. D.

1988-01-01

Reuse of products, processes and knowledge will be the key to enable the software industry to achieve the dramatic improvement in productivity and quality required to satisfy the anticipated growing demand. Although experience shows that certain kinds of reuse can be successful, general success has been elusive. A software life-cycle technology which allows broad and extensive reuse could provide the means to achieving the desired order-of-magnitude improvements. The scope of a comprehensive framework for understanding, planning, evaluating and motivating reuse practices and the necessary research activities is outlined. As a first step towards such a framework, a reuse-enabling software evolution environment model is introduced which provides a basis for the effective recording of experience, the generalization and tailoring of experience, the formalization of experience, and the (re-)use of experience.

The development and piloting of electronic standardized measures on nursing work: combining engineering and nursing knowledge.

PubMed

Bragadóttir, Helga; Gunnarsdóttir, Sigrún; Ingason, Helgi T

2013-05-01

This paper describes the development and piloting of electronic standardized measures on nursing work (e-SMNW) for rich data gathering on the work and work environment of registered nurses (RNs) and practical nurses (PNs). Efficient and valid methods are needed to measure nursing work to enhance the optimal use of the nursing workforce for safe patient care. The study combined human factors engineering (HFE) and nursing knowledge to develop electronic standardized measures for observational studies on nursing work in acute care. The work and work environment of RNs and PNs in acute care medical and surgical inpatient units was successfully measured using e-SMNW. With predetermined items of work activities and influencing factors in the work of nurses, and full use of computer technology, multi-layered rich standardized data were gathered, analysed and displayed. The combination of nursing knowledge, HFE and computer technology enables observational data collection for a rich picture of the complex work of nursing. Information collected by standardized and multi-layered measures makes it easier to identify potential improvements, with regard to influencing factors and management of the work and work environment of nurses. Further use of computer technology in health services research is encouraged. © 2012 Blackwell Publishing Ltd.

Advanced Environmental Monitoring and Control Program: Technology Development Requirements

NASA Technical Reports Server (NTRS)

Jan, Darrell (Editor); Seshan, Panchalam (Editor); Ganapathi, Gani (Editor); Schmidt, Gregory (Editor); Doarn, Charles (Editor)

1996-01-01

Human missions in space, from the International Space Station on towards potential human exploration of the moon, Mars and beyond into the solar system, will require advanced systems to maintain an environment that supports human life. These systems will have to recycle air and water for many months or years at a time, and avoid harmful chemical or microbial contamination. NASA's Advanced Environmental Monitoring and Control program has the mission of providing future spacecraft with advanced, integrated networks of microminiaturized sensors to accurately determine and control the physical, chemical and biological environment of the crew living areas. This document sets out the current state of knowledge for requirements for monitoring the crew environment, based on (1) crew health, and (2) life support monitoring systems. Both areas are updated continuously through research and space mission experience. The technologies developed must meet the needs of future life support systems and of crew health monitoring. These technologies must be inexpensive and lightweight, and use few resources. Using these requirements to continue to push the state of the art in miniaturized sensor and control systems will produce revolutionary technologies to enable detailed knowledge of the crew environment.

A vision for, and progress towards EarthCube

NASA Astrophysics Data System (ADS)

Jacobs, C.

2012-04-01

The National Science Foundation (NSF), a US government agency, seeks to transform the conduct of research in geosciences by supporting innovative approaches to community-created cyberinfrastructure that integrates knowledge management across the Geosciences. Within the NSF organization, the Geosciences Directorate (GEO) and the Office of Cyberinfrastructure (OCI) are partnering to address the multifaceted challenges of modern, data-intensive science and education. NSF encourages the community to envision and create an environment where low adoption thresholds and new capabilities act together to greatly increase the productivity and capability of researchers and educators working at the frontiers of Earth system science. This initiative is EarthCube. NSF believes the geosciences community is well positioned to plan and prototype transformative approaches that use innovative technologies to integrate and make interoperable vast resources of heterogeneous data and knowledge within a knowledge management framework. This believe is founded on tsunami of technology development and application that has and continues to engulf science and investments geosciences has made in cyberinfrastructure (CI) to take advantage the technological developments. However, no master framework for geosciences was employed in the development of technology-enable capabilities required by various geosciences communities. It is time to develop an open, adaptable and sustainable framework (an "EarthCube") to enable transformative research and education of Earth system. This will involve, but limited to fostering common data models and data-focused methodologies; developing next generation search and data tools; and advancing application software to integrate data from various sources to expand the frontiers of knowledge. Also, NSF looks to the community to develop a robust and balanced paradigm to manage a collaborative effort and build community support. Such a paradigm must engage a diverse range of geosciences data collections and collectors, establish sustainable partnerships with other entities that collect data (e.g. other Federal and international agencies), the integrate simulations and observations, and foster symbiotic relationships with industry. Two realize this vision, NSF posted open letters to the community, had several WebEx session, established a social network website to stimulate community dialog (EarthCube.ning.com), held a Charrette with broad community participation, and is accepting expression of interests from the community for the early development efforts of all or part the EarthCube framework.

Towards a Ubiquitous User Model for Profile Sharing and Reuse

PubMed Central

de Lourdes Martinez-Villaseñor, Maria; Gonzalez-Mendoza, Miguel; Hernandez-Gress, Neil

2012-01-01

People interact with systems and applications through several devices and are willing to share information about preferences, interests and characteristics. Social networking profiles, data from advanced sensors attached to personal gadgets, and semantic web technologies such as FOAF and microformats are valuable sources of personal information that could provide a fair understanding of the user, but profile information is scattered over different user models. Some researchers in the ubiquitous user modeling community envision the need to share user model's information from heterogeneous sources. In this paper, we address the syntactic and semantic heterogeneity of user models in order to enable user modeling interoperability. We present a dynamic user profile structure based in Simple Knowledge Organization for the Web (SKOS) to provide knowledge representation for ubiquitous user model. We propose a two-tier matching strategy for concept schemas alignment to enable user modeling interoperability. Our proposal is proved in the application scenario of sharing and reusing data in order to deal with overweight and obesity. PMID:23201995

Envisioning a Future of Computational Geoscience in a Data Rich Semantic World

NASA Astrophysics Data System (ADS)

Kumar, P.; Elag, M.; Jiang, P.; Marini, L.

2015-12-01

Advances in observational systems and reduction in their cost are allowing us to explore, monitor, and digitally represent our environment in unprecedented details and over large areas. Low cost in situ sensors, unmanned autonomous vehicles, imaging technologies, and other new observational approaches along with airborne and space borne systems are allowing us to measure nearly everything, almost everywhere, and at almost all the time. Under the aegis of observatories they are enabling an integrated view across space and time scales ranging from storms to seasons to years and, in some cases, decades. Rapid increase in the convergence of computational, communication and information systems and their inter-operability through advances in technologies such as semantic web can provide opportunities to further facilitate fusion and synthesis of heterogeneous measurements with knowledge systems. This integration can enable us to break disciplinary boundaries and bring sensor data directly to desktop or handheld devices. We describe CyberInfrastructure effort that is being developed through projects such as Earthcube Geosemantics (http://geosemantics.hydrocomplexity.net), (SEAD (http://sead-data.net/), and Browndog (http://browndog.ncsa.illinois.edu/)s o that data across all of earth science can be easily shared and integrated with models. This also includes efforts to enable models to become interoperable among themselves and with data using technologies that enable human-out-of-the-loop integration. Through such technologies our ability to use real time information for decision-making and scientific investigations will increase multifold. The data goes through a sequence of steps, often iterative, from collection to long-term preservation. Similarly the scientific investigation and associated outcomes are composed of a number of iterative steps from problem identification to solutions. However, the integration between these two pathways is rather limited. We describe characteristics of new technologies that are needed to bring these processes together in the near future to significantly reduce the latency between data, science, and agile and informed actions that support sustainability.

Information management to enable personalized medicine: stakeholder roles in building clinical decision support.

PubMed

Downing, Gregory J; Boyle, Scott N; Brinner, Kristin M; Osheroff, Jerome A

2009-10-08

Advances in technology and the scientific understanding of disease processes are presenting new opportunities to improve health through individualized approaches to patient management referred to as personalized medicine. Future health care strategies that deploy genomic technologies and molecular therapies will bring opportunities to prevent, predict, and pre-empt disease processes but will be dependent on knowledge management capabilities for health care providers that are not currently available. A key cornerstone to the potential application of this knowledge will be effective use of electronic health records. In particular, appropriate clinical use of genomic test results and molecularly-targeted therapies present important challenges in patient management that can be effectively addressed using electronic clinical decision support technologies. Approaches to shaping future health information needs for personalized medicine were undertaken by a work group of the American Health Information Community. A needs assessment for clinical decision support in electronic health record systems to support personalized medical practices was conducted to guide health future development activities. Further, a suggested action plan was developed for government, researchers and research institutions, developers of electronic information tools (including clinical guidelines, and quality measures), and standards development organizations to meet the needs for personalized approaches to medical practice. In this article, we focus these activities on stakeholder organizations as an operational framework to help identify and coordinate needs and opportunities for clinical decision support tools to enable personalized medicine. This perspective addresses conceptual approaches that can be undertaken to develop and apply clinical decision support in electronic health record systems to achieve personalized medical care. In addition, to represent meaningful benefits to personalized decision-making, a comparison of current and future applications of clinical decision support to enable individualized medical treatment plans is presented. If clinical decision support tools are to impact outcomes in a clear and positive manner, their development and deployment must therefore consider the needs of the providers, including specific practice needs, information workflow, and practice environment.

Information management to enable personalized medicine: stakeholder roles in building clinical decision support

PubMed Central

2009-01-01

Background Advances in technology and the scientific understanding of disease processes are presenting new opportunities to improve health through individualized approaches to patient management referred to as personalized medicine. Future health care strategies that deploy genomic technologies and molecular therapies will bring opportunities to prevent, predict, and pre-empt disease processes but will be dependent on knowledge management capabilities for health care providers that are not currently available. A key cornerstone to the potential application of this knowledge will be effective use of electronic health records. In particular, appropriate clinical use of genomic test results and molecularly-targeted therapies present important challenges in patient management that can be effectively addressed using electronic clinical decision support technologies. Discussion Approaches to shaping future health information needs for personalized medicine were undertaken by a work group of the American Health Information Community. A needs assessment for clinical decision support in electronic health record systems to support personalized medical practices was conducted to guide health future development activities. Further, a suggested action plan was developed for government, researchers and research institutions, developers of electronic information tools (including clinical guidelines, and quality measures), and standards development organizations to meet the needs for personalized approaches to medical practice. In this article, we focus these activities on stakeholder organizations as an operational framework to help identify and coordinate needs and opportunities for clinical decision support tools to enable personalized medicine. Summary This perspective addresses conceptual approaches that can be undertaken to develop and apply clinical decision support in electronic health record systems to achieve personalized medical care. In addition, to represent meaningful benefits to personalized decision-making, a comparison of current and future applications of clinical decision support to enable individualized medical treatment plans is presented. If clinical decision support tools are to impact outcomes in a clear and positive manner, their development and deployment must therefore consider the needs of the providers, including specific practice needs, information workflow, and practice environment. PMID:19814826

Knowledge-Based Object Detection in Laser Scanning Point Clouds

NASA Astrophysics Data System (ADS)

Boochs, F.; Karmacharya, A.; Marbs, A.

2012-07-01

Object identification and object processing in 3D point clouds have always posed challenges in terms of effectiveness and efficiency. In practice, this process is highly dependent on human interpretation of the scene represented by the point cloud data, as well as the set of modeling tools available for use. Such modeling algorithms are data-driven and concentrate on specific features of the objects, being accessible to numerical models. We present an approach that brings the human expert knowledge about the scene, the objects inside, and their representation by the data and the behavior of algorithms to the machine. This "understanding" enables the machine to assist human interpretation of the scene inside the point cloud. Furthermore, it allows the machine to understand possibilities and limitations of algorithms and to take this into account within the processing chain. This not only assists the researchers in defining optimal processing steps, but also provides suggestions when certain changes or new details emerge from the point cloud. Our approach benefits from the advancement in knowledge technologies within the Semantic Web framework. This advancement has provided a strong base for applications based on knowledge management. In the article we will present and describe the knowledge technologies used for our approach such as Web Ontology Language (OWL), used for formulating the knowledge base and the Semantic Web Rule Language (SWRL) with 3D processing and topologic built-ins, aiming to combine geometrical analysis of 3D point clouds, and specialists' knowledge of the scene and algorithmic processing.

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing.

PubMed

Farley, Toni; Kiefer, Jeff; Lee, Preston; Von Hoff, Daniel; Trent, Jeffrey M; Colbourn, Charles; Mousses, Spyro

2013-01-01

Breakthroughs in molecular profiling technologies are enabling a new data-intensive approach to biomedical research, with the potential to revolutionize how we study, manage, and treat complex diseases. The next great challenge for clinical applications of these innovations will be to create scalable computational solutions for intelligently linking complex biomedical patient data to clinically actionable knowledge. Traditional database management systems (DBMS) are not well suited to representing complex syntactic and semantic relationships in unstructured biomedical information, introducing barriers to realizing such solutions. We propose a scalable computational framework for addressing this need, which leverages a hypergraph-based data model and query language that may be better suited for representing complex multi-lateral, multi-scalar, and multi-dimensional relationships. We also discuss how this framework can be used to create rapid learning knowledge base systems to intelligently capture and relate complex patient data to biomedical knowledge in order to automate the recovery of clinically actionable information.

Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer

PubMed Central

González-Castro, Lorena; Carta, Claudio; van der Horst, Eelke; Lopes, Pedro; Kaliyaperumal, Rajaram; Thompson, Mark; Thompson, Rachel; Queralt-Rosinach, Núria; Lopez, Estrella; Wood, Libby; Robertson, Agata; Lamanna, Claudia; Gilling, Mette; Orth, Michael; Merino-Martinez, Roxana; Taruscio, Domenica; Lochmüller, Hanns

2017-01-01

Patient registries are an essential tool to increase current knowledge regarding rare diseases. Understanding these data is a vital step to improve patient treatments and to create the most adequate tools for personalized medicine. However, the growing number of disease-specific patient registries brings also new technical challenges. Usually, these systems are developed as closed data silos, with independent formats and models, lacking comprehensive mechanisms to enable data sharing. To tackle these challenges, we developed a Semantic Web based solution that allows connecting distributed and heterogeneous registries, enabling the federation of knowledge between multiple independent environments. This semantic layer creates a holistic view over a set of anonymised registries, supporting semantic data representation, integrated access, and querying. The implemented system gave us the opportunity to answer challenging questions across disperse rare disease patient registries. The interconnection between those registries using Semantic Web technologies benefits our final solution in a way that we can query single or multiple instances according to our needs. The outcome is a unique semantic layer, connecting miscellaneous registries and delivering a lightweight holistic perspective over the wealth of knowledge stemming from linked rare disease patient registries. PMID:29214177

Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer.

PubMed

Sernadela, Pedro; González-Castro, Lorena; Carta, Claudio; van der Horst, Eelke; Lopes, Pedro; Kaliyaperumal, Rajaram; Thompson, Mark; Thompson, Rachel; Queralt-Rosinach, Núria; Lopez, Estrella; Wood, Libby; Robertson, Agata; Lamanna, Claudia; Gilling, Mette; Orth, Michael; Merino-Martinez, Roxana; Posada, Manuel; Taruscio, Domenica; Lochmüller, Hanns; Robinson, Peter; Roos, Marco; Oliveira, José Luís

2017-01-01

Patient registries are an essential tool to increase current knowledge regarding rare diseases. Understanding these data is a vital step to improve patient treatments and to create the most adequate tools for personalized medicine. However, the growing number of disease-specific patient registries brings also new technical challenges. Usually, these systems are developed as closed data silos, with independent formats and models, lacking comprehensive mechanisms to enable data sharing. To tackle these challenges, we developed a Semantic Web based solution that allows connecting distributed and heterogeneous registries, enabling the federation of knowledge between multiple independent environments. This semantic layer creates a holistic view over a set of anonymised registries, supporting semantic data representation, integrated access, and querying. The implemented system gave us the opportunity to answer challenging questions across disperse rare disease patient registries. The interconnection between those registries using Semantic Web technologies benefits our final solution in a way that we can query single or multiple instances according to our needs. The outcome is a unique semantic layer, connecting miscellaneous registries and delivering a lightweight holistic perspective over the wealth of knowledge stemming from linked rare disease patient registries.

Report of the In Situ Resources Utilization Workshop

NASA Technical Reports Server (NTRS)

Fairchild, Kyle (Editor); Mendell, Wendell W. (Editor)

1988-01-01

The results of a workshop of 50 representatives from the public and private sector which investigated the potential joint development of the key technologies and mechanisms that will enable the permanent habitation of space are presented. The workshop is an initial step to develop a joint public/private assessment of new technology requirements of future space options, to share knowledge on required technologies that may exist in the private sector, and to investigate potential joint technology development opportunities. The majority of the material was produced in 5 working groups: (1) Construction, Assembly, Automation and Robotics; (2) Prospecting, Mining, and Surface Transportation; (3) Biosystems and Life Support; (4) Materials Processing; and (5) Innovative Ventures. In addition to the results of the working groups, preliminary technology development recommendations to assist in near-term development priority decisions are presented. Finally, steps are outlined for potential new future activities and relationships among the public, private, and academic sectors.

Introduction to biological complexity as a missing link in drug discovery.

PubMed

Gintant, Gary A; George, Christopher H

2018-06-06

Despite a burgeoning knowledge of the intricacies and mechanisms responsible for human disease, technological advances in medicinal chemistry, and more efficient assays used for drug screening, it remains difficult to discover novel and effective pharmacologic therapies. Areas covered: By reference to the primary literature and concepts emerging from academic and industrial drug screening landscapes, the authors propose that this disconnect arises from the inability to scale and integrate responses from simpler model systems to outcomes from more complex and human-based biological systems. Expert opinion: Further collaborative efforts combining target-based and phenotypic-based screening along with systems-based pharmacology and informatics will be necessary to harness the technological breakthroughs of today to derive the novel drug candidates of tomorrow. New questions must be asked of enabling technologies-while recognizing inherent limitations-in a way that moves drug development forward. Attempts to integrate mechanistic and observational information acquired across multiple scales frequently expose the gap between our knowledge and our understanding as the level of complexity increases. We hope that the thoughts and actionable items highlighted will help to inform the directed evolution of the drug discovery process.

A Spacelab Expert System for Remote Engineering and Science

NASA Technical Reports Server (NTRS)

Groleau, Nick; Colombano, Silvano; Friedland, Peter (Technical Monitor)

1994-01-01

NASA's space science program is based on strictly pre-planned activities. This approach does not always result in the best science. We describe an existing computer system that enables space science to be conducted in a more reactive manner through advanced automation techniques that have recently been used in SLS-2 October 1993 space shuttle flight. Advanced computing techniques, usually developed in the field of Artificial Intelligence, allow large portions of the scientific investigator's knowledge to be "packaged" in a portable computer to present advice to the astronaut operator. We strongly believe that this technology has wide applicability to other forms of remote science/engineering. In this brief article, we present the technology of remote science/engineering assistance as implemented for the SLS-2 space shuttle flight. We begin with a logical overview of the system (paying particular attention to the implementation details relevant to the use of the embedded knowledge for system reasoning), then describe its use and success in space, and conclude with ideas about possible earth uses of the technology in the life and medical sciences.

Spaceflight Operations Services Grid (SOSG) Project

NASA Technical Reports Server (NTRS)

Bradford, Robert; Lisotta, Anthony

2004-01-01

The motivation, goals, and objectives of the Space Operations Services Grid Project (SOSG) are covered in this viewgraph presentation. The goals and objectives of SOSG include: 1) Developing a grid-enabled prototype providing Space-based ground operations end user services through a collaborative effort between NASA, academia, and industry to assess the technical and cost feasibility of implementation of Grid technologies in the Space Operations arena; 2) Provide to space operations organizations and processes, through a single secure portal(s), access to all the information technology (Grid and Web based) services necessary for program/project development, operations and the ultimate creation of new processes, information and knowledge.

The Virtual Learning Commons (VLC): Enabling Co-Innovation Across Disciplines

NASA Astrophysics Data System (ADS)

Pennington, D. D.; Gandara, A.; Del Rio, N.

2014-12-01

A key challenge for scientists addressing grand-challenge problems is identifying, understanding, and integrating potentially relevant methods, models and tools that that are rapidly evolving in the informatics community. Such tools are essential for effectively integrating data and models in complex research projects, yet it is often difficult to know what tools are available and it is not easy to understand or evaluate how they might be used in a given research context. The goal of the National Science Foundation-funded Virtual Learning Commons (VLC) is to improve awareness and understanding of emerging methodologies and technologies, facilitate individual and group evaluation of these, and trace the impact of innovations within and across teams, disciplines, and communities. The VLC is a Web-based social bookmarking site designed specifically to support knowledge exchange in research communities. It is founded on well-developed models of technology adoption, diffusion of innovation, and experiential learning. The VLC makes use of Web 2.0 (Social Web) and Web 3.0 (Semantic Web) approaches. Semantic Web approaches enable discovery of potentially relevant methods, models, and tools, while Social Web approaches enable collaborative learning about their function. The VLC is under development and the first release is expected Fall 2014.

Translational Research 2.0: a framework for accelerating collaborative discovery.

PubMed

Asakiewicz, Chris

2014-05-01

The world wide web has revolutionized the conduct of global, cross-disciplinary research. In the life sciences, interdisciplinary approaches to problem solving and collaboration are becoming increasingly important in facilitating knowledge discovery and integration. Web 2.0 technologies promise to have a profound impact - enabling reproducibility, aiding in discovery, and accelerating and transforming medical and healthcare research across the healthcare ecosystem. However, knowledge integration and discovery require a consistent foundation upon which to operate. A foundation should be capable of addressing some of the critical issues associated with how research is conducted within the ecosystem today and how it should be conducted for the future. This article will discuss a framework for enhancing collaborative knowledge discovery across the medical and healthcare research ecosystem. A framework that could serve as a foundation upon which ecosystem stakeholders can enhance the way data, information and knowledge is created, shared and used to accelerate the translation of knowledge from one area of the ecosystem to another.

Evaluating an education/training module to foster knowledge of cockpit weather technology.

PubMed

Cobbett, Erin A; Blickensderfer, Elizabeth L; Lanicci, John

2014-10-01

Previous research has indicated that general aviation (GA) pilots may use the sophisticated meteorological information available to them via a variety of Next-Generation Weather Radar (NEXRAD) based weather products in a manner that actually decreases flight safety. The current study examined an education/training method designed to enable GA pilots to use NEXRAD-based products effectively in convective weather situations. The training method was lecture combined with paper-based scenario exercises. A multivariate analysis of variance revealed that subjects in the training condition performed significantly better than did subjects in the control condition on several knowledge and attitude measures. Subjects in the training condition improved from a mean score of 66% to 80% on the radar-knowledge test and from 62% to 75% on the scenario-knowledge test. Although additional research is needed, these results demonstrated that pilots can benefit from a well-designed education/training program involving specific areas of aviation weather-related knowledge.

Barriers affecting successful technology enablement of supply chain: An Indian perspective

NASA Astrophysics Data System (ADS)

Arora, R.; Haleem, A.; Farooquie, J. A.

2018-03-01

In order to compete, organizations need to focus on improving supply chain and technology acts as a major enabler. Technology enablement of supply chain has not always been successful and has been examined by many researchers. The purpose of this paper is to do a systematic literature review of technology enabled supply chain from a strategic viewpoint. The literature is examined from two perspectives. Firstly, it studies the growing interest in technology-enabled supply chain in India. Secondly, it studies barriers affecting technology enablement of supply chain. The literature review identifies that technology enabled supply chain helps in improving performance via effective decision making, monitoring entire supply chain, faster reaction to customer service problems, etc. The research has emphasized the importance of 12 barriers affecting technology enablement. This research will help as a guide for practitioners in order to successfully implement technology and fills the gap in existing literature by highlighting and consolidating the significant research work done in past.

Platform Architecture for Decentralized Positioning Systems.

PubMed

Kasmi, Zakaria; Norrdine, Abdelmoumen; Blankenbach, Jörg

2017-04-26

A platform architecture for positioning systems is essential for the realization of a flexible localization system, which interacts with other systems and supports various positioning technologies and algorithms. The decentralized processing of a position enables pushing the application-level knowledge into a mobile station and avoids the communication with a central unit such as a server or a base station. In addition, the calculation of the position on low-cost and resource-constrained devices presents a challenge due to the limited computing, storage capacity, as well as power supply. Therefore, we propose a platform architecture that enables the design of a system with the reusability of the components, extensibility (e.g., with other positioning technologies) and interoperability. Furthermore, the position is computed on a low-cost device such as a microcontroller, which simultaneously performs additional tasks such as data collecting or preprocessing based on an operating system. The platform architecture is designed, implemented and evaluated on the basis of two positioning systems: a field strength system and a time of arrival-based positioning system.

"Interactive Classification Technology"

NASA Technical Reports Server (NTRS)

deBessonet, Cary

1999-01-01

The investigators are upgrading a knowledge representation language called SL (Symbolic Language) and an automated reasoning system called SMS (Symbolic Manipulation System) to enable the technologies to be used in automated reasoning and interactive classification systems. The overall goals of the project are: a) the enhancement of the representation language SL to accommodate multiple perspectives and a wider range of meaning; b) the development of a sufficient set of operators to enable the interpreter of SL to handle representations of basic cognitive acts; and c) the development of a default inference scheme to operate over SL notation as it is encoded. As to particular goals the first-year work plan focused on inferencing and.representation issues, including: 1) the development of higher level cognitive/ classification functions and conceptual models for use in inferencing and decision making; 2) the specification of a more detailed scheme of defaults and the enrichment of SL notation to accommodate the scheme; and 3) the adoption of additional perspectives for inferencing.

Proteomic approaches in brain research and neuropharmacology.

PubMed

Vercauteren, Freya G G; Bergeron, John J M; Vandesande, Frans; Arckens, Lut; Quirion, Rémi

2004-10-01

Numerous applications of genomic technologies have enabled the assembly of unprecedented inventories of genes, expressed in cells under specific physiological and pathophysiological conditions. Complementing the valuable information generated through functional genomics with the integrative knowledge of protein expression and function should enable the development of more efficient diagnostic tools and therapeutic agents. Proteomic analyses are particularly suitable to elucidate posttranslational modifications, expression levels and protein-protein interactions of thousands of proteins at a time. In this review, two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) investigations of brain tissues in neurodegenerative diseases such as Alzheimer's disease, Down syndrome and schizophrenia, and the construction of 2D-PAGE proteome maps of the brain are discussed. The role of the Human Proteome Organization (HUPO) as an international coordinating organization for proteomic efforts, as well as challenges for proteomic technologies and data analysis are also addressed. It is expected that the use of proteomic strategies will have significant impact in neuropharmacology over the coming decade.

Platform Architecture for Decentralized Positioning Systems

PubMed Central

Kasmi, Zakaria; Norrdine, Abdelmoumen; Blankenbach, Jörg

2017-01-01

A platform architecture for positioning systems is essential for the realization of a flexible localization system, which interacts with other systems and supports various positioning technologies and algorithms. The decentralized processing of a position enables pushing the application-level knowledge into a mobile station and avoids the communication with a central unit such as a server or a base station. In addition, the calculation of the position on low-cost and resource-constrained devices presents a challenge due to the limited computing, storage capacity, as well as power supply. Therefore, we propose a platform architecture that enables the design of a system with the reusability of the components, extensibility (e.g., with other positioning technologies) and interoperability. Furthermore, the position is computed on a low-cost device such as a microcontroller, which simultaneously performs additional tasks such as data collecting or preprocessing based on an operating system. The platform architecture is designed, implemented and evaluated on the basis of two positioning systems: a field strength system and a time of arrival-based positioning system. PMID:28445414

NICE technology appraisals: working with multiple levels of uncertainty and the potential for bias.

PubMed

Brown, Patrick; Calnan, Michael

2013-05-01

One of the key roles of the English National Institute for Health and Clinical Excellence (NICE) is technology appraisal. This essentially involves evaluating the cost effectiveness of pharmaceutical products and other technologies for use within the National Health Service. Based on a content analysis of key documents which shed light on the nature of appraisals, this paper draws attention to the multiple layers of uncertainty and complexity which are latent within the appraisal process, and the often socially constructed mechanisms for tackling these. Epistemic assumptions, bounded rationality and more explicitly relational forms of managing knowledge are applied to this end. These findings are discussed in the context of the literature highlighting the inherently social process of regulation. A framework is developed which posits the various forms of uncertainty, and responses to these, as potential conduits of regulatory bias-in need of further research. That NICE's authority is itself regulated by other actors within the regulatory regime, particularly the pharmaceutical industry, exposes it to the threat of regulatory capture. Following Lehoux, it is concluded that a more transparent and reflexive format for technological appraisals is necessary. This would enable a more robust, defensible form of decision-making and moreover enable NICE to preserve its legitimacy in the midst of pressures which threaten this.

The emerging Web 2.0 social software: an enabling suite of sociable technologies in health and health care education.

PubMed

Kamel Boulos, Maged N; Wheeler, Steve

2007-03-01

Web 2.0 sociable technologies and social software are presented as enablers in health and health care, for organizations, clinicians, patients and laypersons. They include social networking services, collaborative filtering, social bookmarking, folksonomies, social search engines, file sharing and tagging, mashups, instant messaging, and online multi-player games. The more popular Web 2.0 applications in education, namely wikis, blogs and podcasts, are but the tip of the social software iceberg. Web 2.0 technologies represent a quite revolutionary way of managing and repurposing/remixing online information and knowledge repositories, including clinical and research information, in comparison with the traditional Web 1.0 model. The paper also offers a glimpse of future software, touching on Web 3.0 (the Semantic Web) and how it could be combined with Web 2.0 to produce the ultimate architecture of participation. Although the tools presented in this review look very promising and potentially fit for purpose in many health care applications and scenarios, careful thinking, testing and evaluation research are still needed in order to establish 'best practice models' for leveraging these emerging technologies to boost our teaching and learning productivity, foster stronger 'communities of practice', and support continuing medical education/professional development (CME/CPD) and patient education.

Integration of design and manufacturing in a virtual enterprise using enterprise rules, intelligent agents, STEP, and work flow

NASA Astrophysics Data System (ADS)

Gilman, Charles R.; Aparicio, Manuel; Barry, J.; Durniak, Timothy; Lam, Herman; Ramnath, Rajiv

1997-12-01

An enterprise's ability to deliver new products quickly and efficiently to market is critical for competitive success. While manufactureres recognize the need for speed and flexibility to compete in this market place, companies do not have the time or capital to move to new automation technologies. The National Industrial Information Infrastructure Protocols Consortium's Solutions for MES Adaptable Replicable Technology (NIIIP SMART) subgroup is developing an information infrastructure to enable the integration and interoperation among Manufacturing Execution Systems (MES) and Enterprise Information Systems within an enterprise or among enterprises. The goal of these developments is an adaptable, affordable, reconfigurable, integratable manufacturing system. Key innovative aspects of NIIIP SMART are: (1) Design of an industry standard object model that represents the diverse aspects of MES. (2) Design of a distributed object network to support real-time information sharing. (3) Product data exchange based on STEP and EXPRESS (ISO 10303). (4) Application of workflow and knowledge management technologies to enact manufacturing and business procedures and policy. (5) Application of intelligent agents to support emergent factories. This paper illustrates how these technologies have been incorporated into the NIIIP SMART system architecture to enable the integration and interoperation of existing tools and future MES applications in a 'plug and play' environment.

Biomedical Big Data Training Collaborative (BBDTC): An effort to bridge the talent gap in biomedical science and research.

PubMed

Purawat, Shweta; Cowart, Charles; Amaro, Rommie E; Altintas, Ilkay

2017-05-01

The BBDTC (https://biobigdata.ucsd.edu) is a community-oriented platform to encourage high-quality knowledge dissemination with the aim of growing a well-informed biomedical big data community through collaborative efforts on training and education. The BBDTC is an e-learning platform that empowers the biomedical community to develop, launch and share open training materials. It deploys hands-on software training toolboxes through virtualization technologies such as Amazon EC2 and Virtualbox. The BBDTC facilitates migration of courses across other course management platforms. The framework encourages knowledge sharing and content personalization through the playlist functionality that enables unique learning experiences and accelerates information dissemination to a wider community.

COEUS: “semantic web in a box” for biomedical applications

PubMed Central

2012-01-01

Background As the “omics” revolution unfolds, the growth in data quantity and diversity is bringing about the need for pioneering bioinformatics software, capable of significantly improving the research workflow. To cope with these computer science demands, biomedical software engineers are adopting emerging semantic web technologies that better suit the life sciences domain. The latter’s complex relationships are easily mapped into semantic web graphs, enabling a superior understanding of collected knowledge. Despite increased awareness of semantic web technologies in bioinformatics, their use is still limited. Results COEUS is a new semantic web framework, aiming at a streamlined application development cycle and following a “semantic web in a box” approach. The framework provides a single package including advanced data integration and triplification tools, base ontologies, a web-oriented engine and a flexible exploration API. Resources can be integrated from heterogeneous sources, including CSV and XML files or SQL and SPARQL query results, and mapped directly to one or more ontologies. Advanced interoperability features include REST services, a SPARQL endpoint and LinkedData publication. These enable the creation of multiple applications for web, desktop or mobile environments, and empower a new knowledge federation layer. Conclusions The platform, targeted at biomedical application developers, provides a complete skeleton ready for rapid application deployment, enhancing the creation of new semantic information systems. COEUS is available as open source at http://bioinformatics.ua.pt/coeus/. PMID:23244467

COEUS: "semantic web in a box" for biomedical applications.

PubMed

Lopes, Pedro; Oliveira, José Luís

2012-12-17

As the "omics" revolution unfolds, the growth in data quantity and diversity is bringing about the need for pioneering bioinformatics software, capable of significantly improving the research workflow. To cope with these computer science demands, biomedical software engineers are adopting emerging semantic web technologies that better suit the life sciences domain. The latter's complex relationships are easily mapped into semantic web graphs, enabling a superior understanding of collected knowledge. Despite increased awareness of semantic web technologies in bioinformatics, their use is still limited. COEUS is a new semantic web framework, aiming at a streamlined application development cycle and following a "semantic web in a box" approach. The framework provides a single package including advanced data integration and triplification tools, base ontologies, a web-oriented engine and a flexible exploration API. Resources can be integrated from heterogeneous sources, including CSV and XML files or SQL and SPARQL query results, and mapped directly to one or more ontologies. Advanced interoperability features include REST services, a SPARQL endpoint and LinkedData publication. These enable the creation of multiple applications for web, desktop or mobile environments, and empower a new knowledge federation layer. The platform, targeted at biomedical application developers, provides a complete skeleton ready for rapid application deployment, enhancing the creation of new semantic information systems. COEUS is available as open source at http://bioinformatics.ua.pt/coeus/.

Development of NASA's Small Fission Power System for Science and Human Exploration

NASA Technical Reports Server (NTRS)

Gibson, Marc A.; Mason, Lee; Bowman, Cheryl; Poston, David I.; McClure, Patrick R.; Creasy, John; Robinson, Chris

2014-01-01

Exploration of our solar system has brought great knowledge to our nation's scientific and engineering community over the past several decades. As we expand our visions to explore new, more challenging destinations, we must also expand our technology base to support these new missions. NASA's Space Technology Mission Directorate is tasked with developing these technologies for future mission infusion and continues to seek answers to many existing technology gaps. One such technology gap is related to compact power systems (greater than 1 kWe) that provide abundant power for several years where solar energy is unavailable or inadequate. Below 1 kWe, Radioisotope Power Systems have been the workhorse for NASA and will continue, assuming its availability, to be used for lower power applications similar to the successful missions of Voyager, Ulysses, New Horizons, Cassini, and Curiosity. Above 1 kWe, fission power systems become an attractive technology offering a scalable modular design of the reactor, shield, power conversion, and heat transport subsystems. Near term emphasis has been placed in the 1-10kWe range that lies outside realistic radioisotope power levels and fills a promising technology gap capable of enabling both science and human exploration missions. History has shown that development of space reactors is technically, politically, and financially challenging and requires a new approach to their design and development. A small team of NASA and DOE experts are providing a solution to these enabling FPS technologies starting with the lowest power and most cost effective reactor series named "Kilopower" that is scalable from approximately 1-10 kWe.

Surgical data science: The new knowledge domain

PubMed Central

Vedula, S. Swaroop; Hager, Gregory D.

2017-01-01

Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care with the goal of maximizing quality and value of care. While innovations in diagnostic and therapeutic technologies have driven past improvements in quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytic techniques, and translation or integration of research findings into patient care. We foresee the emergence of Surgical/Interventional Data Science (SDS) as a key element to addressing these limitations and creating a sustainable path toward evidence-based improvement of interventional healthcare pathways. SDS will create tools to measure, model and quantify the pathways or processes within the context of patient health states or outcomes, and use information gained to inform healthcare decisions, guidelines, best practices, policy, and training, thereby improving the safety and quality of healthcare and its value. Data is pervasive throughout the surgical care pathway; thus, SDS can impact various aspects of care including prevention, diagnosis, intervention, or post-operative recovery. Existing literature already provides preliminary results suggesting how a data science approach to surgical decision-making could more accurately predict severe complications using complex data from pre-, intra-, and post-operative contexts, how it could support intra-operative decision-making using both existing knowledge and continuous data streams throughout the surgical care pathway, and how it could enable effective collaboration between human care providers and intelligent technologies. In addition, SDS is poised to play a central role in surgical education, for example, through objective assessments, automated virtual coaching, and robot-assisted active learning of surgical skill. However, the potential for transforming surgical care and training through SDS may only be realized through a cultural shift that not only institutionalizes technology to seamlessly capture data but also assimilates individuals with expertise in data science into clinical research teams. Furthermore, collaboration with industry partners from the inception of the discovery process promotes optimal design of data products as well as their efficient translation and commercialization. As surgery continues to evolve through advances in technology that enhance delivery of care, SDS represents a new knowledge domain to engineer surgical care of the future. PMID:28936475

Surgical data science: The new knowledge domain.

PubMed

Vedula, S Swaroop; Hager, Gregory D

2017-04-01

Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care with the goal of maximizing quality and value of care. While innovations in diagnostic and therapeutic technologies have driven past improvements in quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytic techniques, and translation or integration of research findings into patient care. We foresee the emergence of Surgical/Interventional Data Science (SDS) as a key element to addressing these limitations and creating a sustainable path toward evidence-based improvement of interventional healthcare pathways. SDS will create tools to measure, model and quantify the pathways or processes within the context of patient health states or outcomes, and use information gained to inform healthcare decisions, guidelines, best practices, policy, and training, thereby improving the safety and quality of healthcare and its value. Data is pervasive throughout the surgical care pathway; thus, SDS can impact various aspects of care including prevention, diagnosis, intervention, or post-operative recovery. Existing literature already provides preliminary results suggesting how a data science approach to surgical decision-making could more accurately predict severe complications using complex data from pre-, intra-, and post-operative contexts, how it could support intra-operative decision-making using both existing knowledge and continuous data streams throughout the surgical care pathway, and how it could enable effective collaboration between human care providers and intelligent technologies. In addition, SDS is poised to play a central role in surgical education, for example, through objective assessments, automated virtual coaching, and robot-assisted active learning of surgical skill. However, the potential for transforming surgical care and training through SDS may only be realized through a cultural shift that not only institutionalizes technology to seamlessly capture data but also assimilates individuals with expertise in data science into clinical research teams. Furthermore, collaboration with industry partners from the inception of the discovery process promotes optimal design of data products as well as their efficient translation and commercialization. As surgery continues to evolve through advances in technology that enhance delivery of care, SDS represents a new knowledge domain to engineer surgical care of the future.

Technology Needs for Gamma Ray Astronomy

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2011-01-01

Gamma ray astronomy is currently in an exciting period of multiple missions and a wealth of data. Results from INTEGRAL, Fermi, AGILE, Suzaku and Swift are making large contributions to our knowledge of high energy processes in the universe. The advances are due to new detector and imaging technologies. The steps to date have been from scintillators to solid state detectors for sensors and from light buckets to coded aperture masks and pair telescopes for imagers. A key direction for the future is toward focusing telescopes pushing into the hard X-ray regime and Compton telescopes and pair telescopes with fine spatial resolution for medium and high energy gamma rays. These technologies will provide finer imaging of gamma-ray sources. Importantly, they will also enable large steps forward in sensitivity by reducing background.

A development optical course based on optical fiber white light interference

NASA Astrophysics Data System (ADS)

Jiang, Haili; Sun, Qiuhua; Zhao, Yancheng; Li, Qingbo

2017-08-01

The Michelson interferometer is a very important instrument in optical part for college physics teaching. But most students only know the instrument itself and don't know how to use it in practical engineering problems. A case about optical fiber white light interference based on engineering practice was introduced in the optical teaching of college physics and then designed a development course of university physical optics part. This system based on low-coherence white light interferometric technology can be used to measure distribution strain or temperature. It also could be used in the case of temperature compensation mode.This teaching design can use the knowledge transfer rule to enable students to apply the basic knowledge in the university physics to the new knowledge domain, which can promote the students' ability of using scientific methods to solve complex engineering problems.

Personal technology use by U.S. military service members and veterans: an update.

PubMed

Bush, Nigel E; Wheeler, William M

2015-04-01

Although personal electronic devices, such as mobile phones, computers, and tablets, increasingly are being leveraged as vehicles for health in the civilian world, almost nothing is known about personal technology use in the U.S. military. In 2012 we conducted a unique survey of personal technologies used by U.S. military service members. However, with the rapidly growing sophistication of personal technology and changes in consumer habits, that knowledge must be continuously updated to be useful. Accordingly, we recently surveyed new samples of active duty service members, National Guard and Reserve, and veterans. We collected data by online surveys in 2013 from 239 active, inactive, and former service members. Online surveys were completed in-person via laptop computers at a large military installation and remotely via Web-based surveys posted on the Army Knowledge Online Web site and on a Defense Center Facebook social media channel. We measured high rates of personal technology use by service members at home across popular electronic media. The most dramatic change since our earlier survey was the tremendous increase in mobile phone use at home for a wide variety of purposes. Participants also reported moderate non-work uses of computers and tablets while on recent deployment to Iraq and Afghanistan, but almost no mobile phone use, ostensibly because of military restrictions in the war zone. These latest results will enable researchers and technology developers target their efforts on the most promising and popular technologies for psychological health in the military.

Antenna Technology and other Radio Frequency (RF) Communications Activities at the Glenn Research Center in Support of NASA's Exploration Vision

NASA Technical Reports Server (NTRS)

Miranda, Felix A.

2007-01-01

NASA s Vision for Space Exploration outlines a very ambitious program for the next several decades of the Space Agency endeavors. Ahead is the completion of the International Space Station (ISS); safely flight the shuttle (STS) until 2010; develop and fly the Crew Exploration Vehicle (Orion) by no later than 2014; return to the moon by no later than 2020; extend human presence across the solar system and beyond; implement a sustainable and affordable human and robotic program; develop supporting innovative technologies, knowledge and infrastructure; and promote international and commercial participation in exploration. To achieve these goals, a series of enabling technologies must be developed or matured in a timely manner. Some of these technologies are: spacecraft RF technology (e.g., high power sources and large antennas which using surface receive arrays can get up to 1 Gbps from Mars), uplink arraying (reduce reliance on large ground-based antennas and high operation costs; single point of failure; enable greater data-rates or greater effective distance; scalable, evolvable, flexible scheduling), software define radio (i.e., reconfigurable, flexible interoperability allows for in flight updates open architecture; reduces mass, power, volume), and optical communications (high capacity communications with low mass/power required; significantly increases data rates for deep space). This presentation will discuss some of the work being performed at the NASA Glenn Research Center, Cleveland, Ohio, in antenna technology as well as other on-going RF communications efforts.

Management of Service Projects in Support of Space Flight Research

NASA Technical Reports Server (NTRS)

Love, J.

2009-01-01

Goal:To provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration . [HRP-47051] Specific Objectives: 1) Develop capabilities, necessary countermeasures, and technologies in support of human space exploration, focusing on mitigating the highest risks to human health and performance. 2) Define and improve human spaceflight medical, environmental, and human factors standards. 3) Develop technologies that serve to reduce medical and environmental risks, to reduce human systems resource requirements (mass, volume, power, data, etc.) and to ensure effective human-system integration across exploration systems. 4) Ensure maintenance of Agency core competencies necessary to enable risk reduction in the following areas: A. Space medicine B. Physiological and behavioral effects of long duration spaceflight on the human body C. Space environmental effects, including radiation, on human health and performance D. Space "human factors" [HRP-47051]. Service projects can form integral parts of research-based project-focused programs to provide specialized functions. Traditional/classic project management methodologies and agile approaches are not mutually exclusive paradigms. Agile strategies can be combined with traditional methods and applied in the management of service projects functioning in changing environments. Creative collaborations afford a mechanism for mitigation of constrained resource limitations.

Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruebel, Oliver

2009-11-20

Knowledge discovery from large and complex collections of today's scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research coveredmore » in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics.Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of high-dimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of high-energy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle acceleration, physicists model LWFAs computationally. The datasets produced by LWFA simulations are (i) extremely large, (ii) of varying spatial and temporal resolution, (iii) heterogeneous, and (iv) high-dimensional, making analysis and knowledge discovery from complex LWFA simulation data a challenging task. To address these challenges this thesis describes the integration of the visualization system VisIt and the state-of-the-art index/query system FastBit, enabling interactive visual exploration of extremely large three-dimensional particle datasets. Researchers are especially interested in beams of high-energy particles formed during the course of a simulation. This thesis describes novel methods for automatic detection and analysis of particle beams enabling a more accurate and efficient data analysis process. By integrating these automated analysis methods with visualization, this research enables more accurate, efficient, and effective analysis of LWFA simulation data than previously possible.« less

Three-Dimensional Printing of Nanomaterial Scaffolds for Complex Tissue Regeneration

PubMed Central

O'Brien, Christopher M.; Holmes, Benjamin; Faucett, Scott

2015-01-01

Three-dimensional (3D) printing has recently expanded in popularity, and become the cutting edge of tissue engineering research. A growing emphasis from clinicians on patient-specific care, coupled with an increasing knowledge of cellular and biomaterial interaction, has led researchers to explore new methods that enable the greatest possible control over the arrangement of cells and bioactive nanomaterials in defined scaffold geometries. In this light, the cutting edge technology of 3D printing also enables researchers to more effectively compose multi-material and cell-laden scaffolds with less effort. In this review, we explore the current state of 3D printing with a focus on printing of nanomaterials and their effect on various complex tissue regeneration applications. PMID:25084122

Building new computational models to support health behavior change and maintenance: new opportunities in behavioral research.

PubMed

Spruijt-Metz, Donna; Hekler, Eric; Saranummi, Niilo; Intille, Stephen; Korhonen, Ilkka; Nilsen, Wendy; Rivera, Daniel E; Spring, Bonnie; Michie, Susan; Asch, David A; Sanna, Alberto; Salcedo, Vicente Traver; Kukakfa, Rita; Pavel, Misha

2015-09-01

Adverse and suboptimal health behaviors and habits are responsible for approximately 40 % of preventable deaths, in addition to their unfavorable effects on quality of life and economics. Our current understanding of human behavior is largely based on static "snapshots" of human behavior, rather than ongoing, dynamic feedback loops of behavior in response to ever-changing biological, social, personal, and environmental states. This paper first discusses how new technologies (i.e., mobile sensors, smartphones, ubiquitous computing, and cloud-enabled processing/computing) and emerging systems modeling techniques enable the development of new, dynamic, and empirical models of human behavior that could facilitate just-in-time adaptive, scalable interventions. The paper then describes concrete steps to the creation of robust dynamic mathematical models of behavior including: (1) establishing "gold standard" measures, (2) the creation of a behavioral ontology for shared language and understanding tools that both enable dynamic theorizing across disciplines, (3) the development of data sharing resources, and (4) facilitating improved sharing of mathematical models and tools to support rapid aggregation of the models. We conclude with the discussion of what might be incorporated into a "knowledge commons," which could help to bring together these disparate activities into a unified system and structure for organizing knowledge about behavior.

Concise Review: Organ Engineering: Design, Technology, and Integration.

PubMed

Kaushik, Gaurav; Leijten, Jeroen; Khademhosseini, Ali

2017-01-01

Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed. Stem Cells 2017;35:51-60. © 2016 AlphaMed Press.

Development of an antimicrobial stewardship-based infectious diseases elective that incorporates human patient simulation technology.

PubMed

Falcione, Bonnie A; Meyer, Susan M

2014-10-15

To design an elective for pharmacy students that facilitates antimicrobial stewardship awareness, knowledge, and skill development by solving clinical cases, using human patient simulation technology. The elective was designed for PharmD students to describe principles and functions of stewardship programs, select, evaluate, refine, or redesign patient-specific plans for infectious diseases in the context of antimicrobial stewardship, and propose criteria and stewardship management strategies for an antimicrobial class at a health care institution. Teaching methods included active learning and lectures. Cases of bacterial endocarditis and cryptococcal meningitis were developed that incorporated human patient simulation technology. Forty-five pharmacy students completed an antimicrobial stewardship elective between 2010 and 2013. Outcomes were assessed using student perceptions of and performance on rubric-graded assignments. A PharmD elective using active learning, including novel cases conducted with human patient simulation technology, enabled outcomes consistent with those desired of pharmacists assisting in antimicrobial stewardship programs.

Elderly people's interaction with advanced technology.

PubMed

Blažun, Helena; Vošner, Janez; Kokol, Peter; Saranto, Kaija; Rissanen, Sari

2014-01-01

Aging of population is an inevitable process by which the number of elderly people is increasing. Rapid development of information and communication technology (ICT) is changing basic needs of elderly people; therefore society should ensure opportunities for elderly to learn and use ICT in a way to manage their daily life activities and in this way enable them participation in the information and knowledge society. The purpose of the study was to find out whether elderly are acquainted with the advanced technology and to what extent they use it or they desire to use it. Within the single point study we interviewed 100 randomly selected elderly people from different geographical regions in Slovenia. Results showed the differences in the use of advanced technology by Slovenian regions; therefore in the future activities should be focused on organizing promotional and demonstrational activities including ICT courses to increase elderly's motivation for ICT interaction.

A technological infrastructure to sustain Internetworked Enterprises

NASA Astrophysics Data System (ADS)

La Mattina, Ernesto; Savarino, Vincenzo; Vicari, Claudia; Storelli, Davide; Bianchini, Devis

In the Web 3.0 scenario, where information and services are connected by means of their semantics, organizations can improve their competitive advantage by publishing their business and service descriptions. In this scenario, Semantic Peer to Peer (P2P) can play a key role in defining dynamic and highly reconfigurable infrastructures. Organizations can share knowledge and services, using this infrastructure to move towards value networks, an emerging organizational model characterized by fluid boundaries and complex relationships. This chapter collects and defines the technological requirements and architecture of a modular and multi-Layer Peer to Peer infrastructure for SOA-based applications. This technological infrastructure, based on the combination of Semantic Web and P2P technologies, is intended to sustain Internetworked Enterprise configurations, defining a distributed registry and enabling more expressive queries and efficient routing mechanisms. The following sections focus on the overall architecture, while describing the layers that form it.

Performance of Off-the-Shelf Technologies for Spacecraft Cabin Atmospheric Major Constituent Monitoring

NASA Technical Reports Server (NTRS)

Tatara, J. D.; Perry, J. L.

2004-01-01

Monitoring the atmospheric composition of a crewed spacecraft cabin is central to successfully expanding the breadth and depth of first-hand human knowledge and understanding of space. Highly reliable technologies must be identified and developed to monitor atmospheric composition. This will enable crewed space missions that last weeks, months, and eventually years. Atmospheric composition monitoring is a primary component of any environmental control and life support system. Instrumentation employed to monitor atmospheric composition must be inexpensive, simple, and lightweight and provide robust performance. Such a system will ensure an environment that promotes human safety and health, and that the environment can be maintained with a high degree of confidence. Key to this confidence is the capability for any technology to operate autonomously, with little intervention from the crew or mission control personnel. A study has been conducted using technologies that, with further development, may reach these goals.

Brazilian experiments in Mobile Learning for Health Professionals.

PubMed

Pereira, Samáris Ramiro; Loddi, Sueli Aparecida; Larangeira, Valmir Aparecido; Labrada, Luis; Bandiera-Paiva, Paulo

2013-01-01

The Distance Education has evolved with the available technology in each new decade. The evolution and spread of mobile technology from year 2000s enabled their migration to this new platform: The Mobile Learning. Making it possible for professionals and students can carry with multimedia tools with Internet access to learning tools or professional references. This new concept fits very well the needs of Health, in which students must absorb and put into practice large amounts of technical knowledge, and also professionals must stay constantly updated. Distance Education in Health has received prominence in Brazil. A country of a geographically dispersed group of professionals, and research & training centers concentrated in the capitals. Updating field teams is a difficult task, but the information has access to modern technologies, which contribute to the teachers who use them. This paper, through the methodology of literature review, presents technology experiments in health environments and their considerations.

Enabling Logistics With Portable and Wireless Technology Study. Volume 1

DTIC Science & Technology

2004-08-06

Project”, Ubiquitous Computing Group Microsoft Research, 2001. 102 Enabling Logistics with Portable and Wireless Technology Study ...Enabling Logistics with Portable and Wireless Technology Study Final Report FINAL REPORT...Volume I) Enabling Logistics with Portable and Wireless Technology Study AUTHORS School of Industrial Engineering Dr. Soundar Kumara

The Effectiveness of a Geospatial Technologies-Integrated Curriculum to Promote Climate Literacy

NASA Astrophysics Data System (ADS)

Anastasio, D. J.; Bodzin, A. M.; Peffer, T.; Sahagian, D. L.; Cirucci, L.

2011-12-01

This study examined the effectiveness of a geospatial technologies - integrated climate change curriculum (http://www.ei.lehigh.edu/eli/cc/) to promote climate literacy in an urban school district. Five 8th grade Earth and Space Science classes in an urban middle school (Bethlehem, Pennsylvania) consisting of three different ability level tracks participated in the study. Data gathering methods included pre/posttest assessments, daily classroom observations, daily teacher meetings, and examination of student produced artifacts. Data was gathered using a climate change literacy assessment instrument designed to measure students' climate change content knowledge. The items included distractors that address misunderstandings and knowledge deficits about climate change from the existing literature. Paired-sample t-test analyses were conducted to compare the pre- and post-test assessment results. The results of these analyses were used to compare overall gains as well as ability level track groups. Overall results regarding the use of the climate change curriculum showed significant improvement in urban middle school students' understanding of climate change concepts. Effect sizes were large (ES>0.8) and significant (p<0.001) for the entire assessment and for each ability level subgroup. Findings from classroom observations, assessments embedded in the curriculum, and the examination of all student artifacts revealed that the use of geospatial technologies enable middle school students to improve their knowledge of climate change and improve their spatial thinking and reasoning skills.

Collaborative data model and data base development for paleoenvironmental and archaeological domain using Semantic MediaWiki

NASA Astrophysics Data System (ADS)

Willmes, C.

2017-12-01

In the frame of the Collaborative Research Centre 806 (CRC 806) an interdisciplinary research project, that needs to manage data, information and knowledge from heterogeneous domains, such as archeology, cultural sciences, and the geosciences, a collaborative internal knowledge base system was developed. The system is based on the open source MediaWiki software, that is well known as the software that enables Wikipedia, for its facilitation of a web based collaborative knowledge and information management platform. This software is additionally enhanced with the Semantic MediaWiki (SMW) extension, that allows to store and manage structural data within the Wiki platform, as well as it facilitates complex query and API interfaces to the structured data stored in the SMW data base. Using an additional open source software called mobo, it is possible to improve the data model development process, as well as automated data imports, from small spreadsheets to large relational databases. Mobo is a command line tool that helps building and deploying SMW structure in an agile, Schema-Driven Development way, and allows to manage and collaboratively develop the data model formalizations, that are formalized in JSON-Schema format, using version control systems like git. The combination of a well equipped collaborative web platform facilitated by Mediawiki, the possibility to store and query structured data in this collaborative database provided by SMW, as well as the possibility for automated data import and data model development enabled by mobo, result in a powerful but flexible system to build and develop a collaborative knowledge base system. Furthermore, SMW allows the application of Semantic Web technology, the structured data can be exported into RDF, thus it is possible to set a triple-store including a SPARQL endpoint on top of the database. The JSON-Schema based data models, can be enhanced into JSON-LD, to facilitate and profit from the possibilities of Linked Data technology.

Personalized Medicine Across Disciplines and without Borders. Vural Özdemir speaks to Hannah Wilson, Commissioning Editor.

PubMed

Özdemir, Vural

Vural Özdemir began his career as a medical doctor in Turkey in 1990, as a scientist at the Faculty of Medicine, University of Toronto (ON, Canada), where he obtained his MSc and PhD in clinical pharmacology (1998), and subsequently completed a 4-year postdoctoral fellowship in personalized medicine with the late Werner Kalow, a founding pioneer in the field of pharmacogenetics. Özdemir contributed to the conception and development of the repeated drug administration (RDA) method as a novel way of measuring pharmacological heritability, pharmacogenetics of psychiatric drugs and studying the clinical role of CYP2D6 genetic variations for endogenous neurotransmitter metabolism in the human brain. Recognizing that scientific knowledge is a product of both technology and social systems that often remain unaccounted for (e.g., human values, distribution of power and human agency, immigration, racial disparities, socioeconomic class and equity), Özdemir discovered the literature in the field of science and technology studies, a rich scholarly enquiry that asks fundamental questions and challenges assumptions regarding the backstage of technoscience, situates technology within its political context and makes hitherto unseen connections that frame science in ways that enable robust, responsible and sustainable innovation. From 2008 to 2012, Özdemir was awarded a mid-career "science and society" fellowship in order to retool as independent faculty and senior scientist in science and technology studies (STS), conducting research on research and examining his own trade - pharmacogenetics science - as an insider on the outside. Recently, Özdemir was awarded senior career support from the Scientific and Tehnological Research Council of Turkey, is an Associate Professor of both Communications and Human Genetics at the Faculty of Communications and serves as an advisor to the Rector for International Technology and Innovation Policy, Gaziantep University in Turkey. He is also a Visiting Professor (Global Health & Technology Foresight) at Amrita University in Kerala, India, and cofounder of the Data-Enabled Life Sciences Alliance (DELSA Global), an open innovation and knowledge translation platform in Seattle (WA, USA). Özdemir was named as coinventor of 12 World Intellectual Property Organization (WIPO) indexed patents in personalized medicine and has authored more than 130 peer reviewed articles and chapters on the translation of omics technologies into public health action, global technology governance, diagnostics innovation strategy, history of bioethics and the ethics-of-bioethics. 'Science Peace Corps' and 'Microgrants for Big Data' are two new knowledge translation and science communication concepts developed by Özdemir for the global governance of biotechnology. He is Editor-in-Chief of OMICS: A Journal of Integrative Biology , published by Mary Ann Liebert, Inc. (NY, USA).

Scientific Knowledge and Technology, Animal Experimentation, and Pharmaceutical Development.

PubMed

Kinter, Lewis B; DeGeorge, Joseph J

2016-12-01

Human discovery of pharmacologically active substances is arguably the oldest of the biomedical sciences with origins >3500 years ago. Since ancient times, four major transformations have dramatically impacted pharmaceutical development, each driven by advances in scientific knowledge, technology, and/or regulation: (1) anesthesia, analgesia, and antisepsis; (2) medicinal chemistry; (3) regulatory toxicology; and (4) targeted drug discovery. Animal experimentation in pharmaceutical development is a modern phenomenon dating from the 20th century and enabling several of the four transformations. While each transformation resulted in more effective and/or safer pharmaceuticals, overall attrition, cycle time, cost, numbers of animals used, and low probability of success for new products remain concerns, and pharmaceutical development remains a very high risk business proposition. In this manuscript we review pharmaceutical development since ancient times, describe its coevolution with animal experimentation, and attempt to predict the characteristics of future transformations. © The Author 2016. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Picturing the nurse-person/family/community process in the year 2050.

PubMed

Mitchell, Gail J

2007-01-01

How will nurses relate with persons in the year 2050? And, how might technology enable or limit the nursing process with persons, families, and communities? These are the questions addressed in this column. Imaging practice in light of the technological imaginings and projections is facilitated by a possible scenario that includes robotics that not only monitor human biological processes, they also emote compassion and caring that may one day be dosed according to the latest diagnostic prescription. Three nurses in this column present their views of how nursing might evolve. Karnick, aligned with the human becoming school of thought, imagines a practice anchored in respect for humanity and quality of life and an accompanying respect for nursing knowledge and nursing work. Senesac and Sato, aligned with Roy's adaptation model, call for nurses to envision and choose the future they want to have. Clear in both perspectives is a reverence for human values and human experience and for the critical role of nursing knowledge as we move toward the not-yet of 2050.

Connectivism: A knowledge learning theory for the digital age?

PubMed

Goldie, John Gerard Scott

2016-10-01

The emergence of the internet, particularly Web 2.0 has provided access to the views and opinions of a wide range of individuals opening up opportunities for new forms of communication and knowledge formation. Previous ways of navigating and filtering available information are likely to prove ineffective in these new contexts. Connectivism is one of the most prominent of the network learning theories which have been developed for e-learning environments. It is beginning to be recognized by medical educators. This article aims to examine connectivism and its potential application. The conceptual framework and application of connectivism are presented along with an outline of the main criticisms. Its potential application in medical education is then considered. While connectivism provides a useful lens through which teaching and learning using digital technologies can be better understood and managed, further development and testing is required. There is unlikely to be a single theory that will explain learning in technological enabled networks. Educators have an important role to play in online network learning.

Ah, That New Car Smell: NASA Technology Protects Spacecraft from Outgassed Molecular Contaminants

NASA Image and Video Library

2017-12-08

Goddard technologist Nithin Abraham, a member of the team that has developed a low-cost, low-mass technique for protecting sensitive spacecraft components from outgassed contaminants, studies a paint sample in her laboratory. To read this story go to: www.nasa.gov/topics/technology/features/outgas-tech.html Credit: NASA/Pat Izzo NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Design Constraints Regarding The Use Of Fluids In Emergency Medical Systems For Space Flight

NASA Technical Reports Server (NTRS)

McQuillen, John

2013-01-01

The Exploration Medical Capability Project of the Human Research Program is tasked with identifying, investigating and addressing gaps existing gaps in either knowledge or technology that need to be addressed in order to enable safer exploration missions. There are several gaps that involve treatment for emergency medical situations. Some of these treatments involve the handling of liquids in the spacecraft environment which involve gas-liquid mixtures handling, dissolution chemistry and thermal issues. Some of the recent technology efforts include the Intravenous fluid generation (IVGEN) experiment, the In-Suit Injection System (ISIS) experiment, and medical suction. Constraints include limited volume, shelf life, handling biohazards, availability of power, crew time and medical training.

The Virtual Learning Commons: An Emerging Technology for Learning About Emerging Technologies

NASA Astrophysics Data System (ADS)

Pennington, D. D.; Del Rio, N.; Fierro, C.; Gandara, A.; Garcia, A.; Garza, J.; Giandoni, M.; Ochoa, O.; Padilla, E.; Salamah, S.

2013-12-01

The Virtual Learning Commons (VLC), funded by the National Science Foundation Office of Cyberinfrastructure CI-Team Program, is a combination of semantic, visualization, and social media tools that support knowledge sharing and innovation across research disciplines. The explosion of new scientific tools and techniques challenges the ability of researchers to be aware of emerging technologies that might benefit them. Even when aware, it can be difficult to understand enough about emerging technologies to become potential adopters or re-users. Often, emerging technologies have little documentation, especially about the context of their use. The VLC tackles this challenge by providing mechanisms for individuals and groups of researchers to collectively organize Web resources through social bookmarking, and engage each other around those collections in order to a) learn about potentially relevant technologies that are emerging; and b) get feedback from other researchers on innovative ideas and designs. Concurrently, developers of emerging technologies can learn about potential users and the issues they encounter, and they can analyze the impact of their tools on other projects. The VLC aims to support the 'fuzzy front end' of innovation, where novel ideas emerge and there is the greatest potential for impact on research design. It is during the fuzzy front end that conceptual collisions across disciplines and exposure to diverse perspectives provide opportunity for creative thinking that can lead to inventive outcomes. This presentation will discuss the innovation theories that have informed design of the VLC, and hypotheses about the flow of information in virtual settings that can enable the process of innovation. The presentation will include a brief demonstration of key capabilities within the VLC that enable learning about emerging technologies, including the technologies that are presented in this session.

Three-year program to improve critical 1-micron Qsw laser technology for Earth observation

NASA Astrophysics Data System (ADS)

Sakaizawa, Daisuke; Chishiki, Yoshikazu; Satoh, Yohei; Hanada, Tatsuyuki; Yamakawa, Shiro; Ogawa, Takayo; Wada, Satoshi; Ishii, Shoken; Mizutani, Kohei; Yasui, Motoaki

2012-11-01

Laser remote sensing technologies are valuable for a variety of scientific requirements. These measurement techniques are involved in several earth science areas, including atmospheric chemistry, aerosols and clouds, wind speed and directions, prediction of pollution, oceanic mixed layer depth, vegetation canopy height (biomass), ice sheet, surface topography, and others. Much of these measurements have been performed from the ground to aircraft over the past decades. To improve knowledge of these science areas with transport models (e.g. AGCM), further advances of vertical profile are required. JAXA collaborated with NICT and RIKEN started a new cross-sectional 3-year program to improve a technology readiness of the critical 1-micron wavelengths from 2011. The efficient frequency conversions such as second and third harmonic generation and optical parametric oscillation/generation are applied. A variety of elements are common issues to lidar instruments, which includes heat rejection using high thermal conductivity materials, laser diode life time and reliability, wavelength control, and suppression of contamination control. And the program has invested in several critical areas including advanced laser transmitter technologies to enable science measurements and improvement of knowledge for space-based laser diode arrays, Pockels cells, advanced nonlinear wavelength conversion technology for space-based LIDIRs. Final goal is aim to realize 15 watt class Q-switched pulse laser over 3-year lifetime.

KSC/IT Knowledge Sharing With JAXA/IT

NASA Technical Reports Server (NTRS)

Turner, Stacie

2010-01-01

The mission of NASA IT [organizations throughout the Agency] is to increase the productivity of scientists, engineers, and mission support personnel by responsively and efficiently delivering reliable, innovative and secure IT services. (http://insidenasa.nasa.gov/ocio/about/index.html, July 2010) IT at NASA/KSC serves to enable KSC's mission (Human Space Flight) in a customer-focused manner by offering a breadth of IT services to support the current and advanced information technology and communications needs of KSC institutional and NASA/KSC program customers.

Knowledge-Based Extensible Natural Language Interface Technology Program

DTIC Science & Technology

1989-11-30

natural language as its own meta-language to explain the meaning and attributes of the words and idioms of the larguage. Educational courses in language...understood and used by Lydia for human-computer dialogue. The KL enables a systems developer or " teacher -user" to build the system to a point where new...language can be "formal" as in a structured educational language program or it can be "informal" as in the case of a person consulting a dictionary for the

Building High-Performing Commander Leader Teams: Intensive Collaboration Enabled by Information Technology and Knowledge Management

DTIC Science & Technology

2006-12-01

In- formation Officer (CIO)/G- 6 , and the U.S. Army Combined Arms Center, Ft. Leavenworth, Kansas in partial fulfillment of the “Independent...Army governance of BCKS (DA CIO/G- 6 , DA G-3, and Com- manding General, US Army Combined Arms Center) for the opportunity to develop these proposed...Operations Sketch for “Clear the Main Supply Route ” ............ G-4 Figure G-2. “Duffer’s Drift” Execution (Student-interactor overwatched by the

Proceedings of the Strategic Computing Natural Language Workshop Held in Marina del Rey, California on 1-2 May 1986.

DTIC Science & Technology

1986-05-01

more specific top level goals supporting this single broad objective are to produce technology that will: 1. enable the operation of military systems...the boundary between semantics and pragmatics. These are problems that arise in single sentences, even though one may have to look beyond the single ...instances of metonymy seem to require only type knowledge. (4) At the most abstract level, interpretation requires the constructive proof of a single

Secure, Autonomous, Intelligent Controller for Integrating Distributed Sensor Webs

NASA Technical Reports Server (NTRS)

Ivancic, William D.

2007-01-01

This paper describes the infrastructure and protocols necessary to enable near-real-time commanding, access to space-based assets, and the secure interoperation between sensor webs owned and controlled by various entities. Select terrestrial and aeronautics-base sensor webs will be used to demonstrate time-critical interoperability between integrated, intelligent sensor webs both terrestrial and between terrestrial and space-based assets. For this work, a Secure, Autonomous, Intelligent Controller and knowledge generation unit is implemented using Virtual Mission Operation Center technology.

Properties of centralized cooperative sensing in cognitive radio networks

NASA Astrophysics Data System (ADS)

Skokowski, Paweł; Malon, Krzysztof; Łopatka, Jerzy

2017-04-01

Spectrum sensing is a functionality that enables network creation in the cognitive radio technology. Spectrum sensing is use for building the situation awareness knowledge for better use of radio resources and to adjust network parameters in case of jamming, interferences from legacy systems, decreasing link quality caused e.g. by nodes positions changes. This paper presents results from performed tests to compare cooperative centralized sensing versus local sensing. All tests were performed in created simulator developed in Matlab/Simulink environment.

Elaboration and formalization of current scientific knowledge of risks and preventive measures illustrated by colorectal cancer.

PubMed

Giorgi, R; Gouvernet, J; Dufour, J; Degoulet, P; Laugier, R; Quilichini, F; Fieschi, M

2001-01-01

Present the method used to elaborate and formalize current scientific knowledge to provide physicians with tools available on the Internet, that enable them to evaluate individual patient risk, give personalized preventive recommendations or early screening measures. The approach suggested in this article is in line with medical procedures based on levels of evidence (Evidence-based Medicine). A cyclical process for developing recommendations allows us to quickly incorporate current scientific information. At each phase, the analysis is reevaluated by experts in the field collaborating on the project. The information is formalized through the use of levels of evidence and grades of recommendations. GLIF model is used to implement recommendations for clinical practice guidelines. The most current scientific evidence incorporated in a cyclical process includes several steps: critical analysis according to the Evidence-based Medicine method; identification of predictive factors; setting-up risk levels; identification of prevention measures; elaboration of personalized recommendation. The information technology implementation of the clinical practice guideline enables physicians to quickly obtain personalized information for their patients. Cases of colorectal prevention illustrate our approach. Integration of current scientific knowledge is an important process. The delay between the moment new information arrives and the moment the practitioner applies it, is thus reduced.

Physician communication via Internet-enabled technology: A systematic review.

PubMed

Barr, Neil G; Randall, Glen E; Archer, Norman P; Musson, David M

2017-10-01

The use of Internet-enabled technology (information and communication technology such as smartphone applications) may enrich information exchange among providers and, consequently, improve health care delivery. The purpose of this systematic review was to gain a greater understanding of the role that Internet-enabled technology plays in enhancing communication among physicians. Studies were identified through a search in three electronic platforms: the Association for Computing Machinery Digital Library, ProQuest, and Web of Science. The search identified 5140 articles; of these, 21 met all inclusion criteria. In general, physicians were satisfied with Internet-enabled technology, but consensus was lacking regarding whether Internet-enabled technology improved efficiency or made a difference to clinical decision-making. Internet-enabled technology can play an important role in enhancing communication among physicians, but the extent of that benefit is influenced by (1) the impact of Internet-enabled technology on existing work practices, (2) the availability of adequate resources, and (3) the nature of institutional elements, such as privacy legislation.

Comparative development of knowledge-based bioeconomy in the European Union and Turkey.

PubMed

Celikkanat Ozan, Didem; Baran, Yusuf

2014-09-01

Biotechnology, defined as the technological application that uses biological systems and living organisms, or their derivatives, to create or modify diverse products or processes, is widely used for healthcare, agricultural and environmental applications. The continuity in industrial applications of biotechnology enables the rise and development of the bioeconomy concept. Bioeconomy, including all applications of biotechnology, is defined as translation of knowledge received from life sciences into new, sustainable, environment friendly and competitive products. With the advanced research and eco-efficient processes in the scope of bioeconomy, more healthy and sustainable life is promised. Knowledge-based bioeconomy with its economic, social and environmental potential has already been brought to the research agendas of European Union (EU) countries. The aim of this study is to summarize the development of knowledge-based bioeconomy in EU countries and to evaluate Turkey's current situation compared to them. EU-funded biotechnology research projects under FP6 and FP7 and nationally-funded biotechnology projects under The Scientific and Technological Research Council of Turkey (TUBITAK) Academic Research Funding Program Directorate (ARDEB) and Technology and Innovation Funding Programs Directorate (TEYDEB) were examined. In the context of this study, the main research areas and subfields which have been funded, the budget spent and the number of projects funded since 2003 both nationally and EU-wide and the gaps and overlapping topics were analyzed. In consideration of the results, detailed suggestions for Turkey have been proposed. The research results are expected to be used as a roadmap for coordinating the stakeholders of bioeconomy and integrating Turkish Research Areas into European Research Areas.

Application of Ontologies for Big Earth Data

NASA Astrophysics Data System (ADS)

Huang, T.; Chang, G.; Armstrong, E. M.; Boening, C.

2014-12-01

Connected data is smarter data! Earth Science research infrastructure must do more than just being able to support temporal, geospatial discovery of satellite data. As the Earth Science data archives continue to expand across NASA data centers, the research communities are demanding smarter data services. A successful research infrastructure must be able to present researchers the complete picture, that is, datasets with linked citations, related interdisciplinary data, imageries, current events, social media discussions, and scientific data tools that are relevant to the particular dataset. The popular Semantic Web for Earth and Environmental Terminology (SWEET) ontologies is a collection of ontologies and concepts designed to improve discovery and application of Earth Science data. The SWEET ontologies collection was initially developed to capture the relationships between keywords in the NASA Global Change Master Directory (GCMD). Over the years this popular ontologies collection has expanded to cover over 200 ontologies and 6000 concepts to enable scalable classification of Earth system science concepts and Space science. This presentation discusses the semantic web technologies as the enabling technology for data-intensive science. We will discuss the application of the SWEET ontologies as a critical component in knowledge-driven research infrastructure for some of the recent projects, which include the DARPA Ontological System for Context Artifact and Resources (OSCAR), 2013 NASA ACCESS Virtual Quality Screening Service (VQSS), and the 2013 NASA Sea Level Change Portal (SLCP) projects. The presentation will also discuss the benefits in using semantic web technologies in developing research infrastructure for Big Earth Science Data in an attempt to "accommodate all domains and provide the necessary glue for information to be cross-linked, correlated, and discovered in a semantically rich manner." [1] [1] Savas Parastatidis: A platform for all that we know: creating a knowledge-driven research infrastructure. The Fourth Paradigm 2009: 165-172

Knowledge Acquisition and Job Training for Advanced Technical Skills Using Immersive Virtual Environment

NASA Astrophysics Data System (ADS)

Watanuki, Keiichi; Kojima, Kazuyuki

The environment in which Japanese industry has achieved great respect is changing tremendously due to the globalization of world economies, while Asian countries are undergoing economic and technical development as well as benefiting from the advances in information technology. For example, in the design of custom-made casting products, a designer who lacks knowledge of casting may not be able to produce a good design. In order to obtain a good design and manufacturing result, it is necessary to equip the designer and manufacturer with a support system related to casting design, or a so-called knowledge transfer and creation system. This paper proposes a new virtual reality based knowledge acquisition and job training system for casting design, which is composed of the explicit and tacit knowledge transfer systems using synchronized multimedia and the knowledge internalization system using portable virtual environment. In our proposed system, the education content is displayed in the immersive virtual environment, whereby a trainee may experience work in the virtual site operation. Provided that the trainee has gained explicit and tacit knowledge of casting through the multimedia-based knowledge transfer system, the immersive virtual environment catalyzes the internalization of knowledge and also enables the trainee to gain tacit knowledge before undergoing on-the-job training at a real-time operation site.

Students' perceptions of clinical teaching and learning strategies: a Pakistani perspective.

PubMed

Khan, Basnama Ayaz; Ali, Fauziya; Vazir, Nilofar; Barolia, Rubina; Rehan, Seema

2012-01-01

The complexity of the health care environment is increasing with the explosion of technology, coupled with the issues of patients' access, equity, time efficiency, and cost containment. Nursing education must focus on means that enable students to develop the processes of active learning, problem-solving, and critical thinking, in order to enable them to deal with the complexities. This study aims at identifying the nursing students' perceptions about the effectiveness of utilized teaching and learning strategies of clinical education, in improving students' knowledge, skills, and attitudes. A descriptive cross sectional study design was utilized using both qualitative and quantitative approaches. Data were collected from 74 students, using a questionnaire that was developed for the purpose of the study and analyzed using descriptive and non-parametric statistics. The findings revealed that demonstration was the most effective strategy for improving students' skills; reflection, for improving attitudes; and problem based learning and concept map for improving their knowledge. Students' responses to open-ended questions confirmed the effectiveness of these strategies in improving their learning outcomes. Recommendations have been provided based on the findings. Copyright © 2011 Elsevier Ltd. All rights reserved.

Transformative Learning: Patterns of Psychophysiologic Response and Technology-Enabled Learning and Intervention Systems

DTIC Science & Technology

2008-09-01

Psychophysiologic Response and Technology -Enabled Learning and Intervention Systems PRINCIPAL INVESTIGATOR: Leigh W. Jerome, Ph.D...NUMBER Transformative Learning : Patterns of Psychophysiologic Response and Technology - Enabled Learning and Intervention Systems 5b. GRANT NUMBER...project entitled “Transformative Learning : Patterns of Psychophysiologic Response in Technology Enabled Learning and Intervention Systems.” The

The Role of Learning Goals in Building a Knowledge Base for Elementary Mathematics Teacher Education

ERIC Educational Resources Information Center

Jansen, Amanda; Bartell, Tonya; Berk, Dawn

2009-01-01

In this article, we describe features of learning goals that enable indexing knowledge for teacher education. Learning goals are the key enabler for building a knowledge base for teacher education; they define what counts as essential knowledge for prospective teachers. We argue that 2 characteristics of learning goals support knowledge-building…

Microsystem technology as a road from macro to nanoworld.

PubMed

Grabiec, Piotr; Domański, Krzysztof; Janus, Paweł; Zaborowski, Michał; Jaroszewicz, Bogdan

2005-04-01

Tremendous progress of microelectronic technology observed within last 40 years is closely related to even more remarkable progress of technological tools. It is important to note however, that these new tools may be used for fabrication of diverse multifunctional structures as well. Such devices, called MEMS (Micro-Electro-Mechanical-System) and MOEMS (Micro-Electro-Opto-Mechanical-System) integrate microelectronic and micromechanical structures in one system enabling interdisciplinary application, with most interesting and prospective being bio-medical investigations. Development of these applications requires however cooperation of multidisciplinary team of specialists, covering broad range of physics, (bio) chemistry and electronics, not mentioning medical doctors and other medical specialists. Thus, dissemination, of knowledge about existing processing capabilities is of key importance. In this paper, examples of various applications of microelectronic technology for fabrication of Microsystems which may be used for medicine and chemistry, will be presented. Besides, information concerning a design and technology potential available in poland and new, emerging opportunities will be given.

Biometrics-based service marketing issues: exploring acceptability and risk factors of iris scans associated with registered travel programmes.

PubMed

Smith, Alan D

2008-01-01

The marketability and viability of biometric technologies by companies marketing their own versions of pre-approved registered travel programmes have generated a number of controversies. Data were collected and analysed to formulate graphs, run regression and correlation analyses, and use Chi-square to formally test basic research propositions on a sample of 241 professionals in the Pittsburgh area. It was found that there was a significant relationship between the respondents' familiarity with new technology (namely web-enabled and internet sophistication) and knowledge of biometrics, in particular iris scans. Participants who frequently use the internet are more comfortable with innovative technology; although individuals with higher income levels have less trust in the government, it appeared that virtually everyone is concerned about trusting the government with their personal information. Healthcare professionals need to document the safety, CRM-related factors, and provide leadership in the international collaboration of biometric-related personal identification technologies, since they will be one of the main beneficiaries of the implementation of such technologies.

Advanced Earth-to-orbit propulsion technology program overview: Impact of civil space technology initiative

NASA Technical Reports Server (NTRS)

Stephenson, Frank W., Jr.

1988-01-01

The NASA Earth-to-Orbit (ETO) Propulsion Technology Program is dedicated to advancing rocket engine technologies for the development of fully reusable engine systems that will enable space transportation systems to achieve low cost, routine access to space. The program addresses technology advancements in the areas of engine life extension/prediction, performance enhancements, reduced ground operations costs, and in-flight fault tolerant engine operations. The primary objective is to acquire increased knowledge and understanding of rocket engine chemical and physical processes in order to evolve more realistic analytical simulations of engine internal environments, to derive more accurate predictions of steady and unsteady loads, and using improved structural analyses, to more accurately predict component life and performance, and finally to identify and verify more durable advanced design concepts. In addition, efforts were focused on engine diagnostic needs and advances that would allow integrated health monitoring systems to be developed for enhanced maintainability, automated servicing, inspection, and checkout, and ultimately, in-flight fault tolerant engine operations.

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing

PubMed Central

Farley, Toni; Kiefer, Jeff; Lee, Preston; Von Hoff, Daniel; Trent, Jeffrey M; Colbourn, Charles

2013-01-01

Breakthroughs in molecular profiling technologies are enabling a new data-intensive approach to biomedical research, with the potential to revolutionize how we study, manage, and treat complex diseases. The next great challenge for clinical applications of these innovations will be to create scalable computational solutions for intelligently linking complex biomedical patient data to clinically actionable knowledge. Traditional database management systems (DBMS) are not well suited to representing complex syntactic and semantic relationships in unstructured biomedical information, introducing barriers to realizing such solutions. We propose a scalable computational framework for addressing this need, which leverages a hypergraph-based data model and query language that may be better suited for representing complex multi-lateral, multi-scalar, and multi-dimensional relationships. We also discuss how this framework can be used to create rapid learning knowledge base systems to intelligently capture and relate complex patient data to biomedical knowledge in order to automate the recovery of clinically actionable information. PMID:22859646

Spooled packaging of shape memory alloy actuators

NASA Astrophysics Data System (ADS)

Redmond, John A.

A vast cross-section of transportation, manufacturing, consumer product, and medical technologies rely heavily on actuation. Accordingly, progress in these industries is often strongly coupled to the advancement of actuation technologies. As the field of actuation continues to evolve, smart materials show significant promise for satisfying the growing needs of industry. In particular, shape memory alloy (SMA) wire actuators present an opportunity for low-cost, high performance actuation, but until now, they have been limited or restricted from use in many otherwise suitable applications by the difficulty in packaging the SMA wires within tight or unusually shaped form constraints. To address this packaging problem, SMA wires can be spool-packaged by wrapping around mandrels to make the actuator more compact or by redirecting around multiple mandrels to customize SMA wire pathways to unusual form factors. The goal of this dissertation is to develop the scientific knowledge base for spooled packaging of low-cost SMA wire actuators that enables high, predictable performance within compact, customizable form factors. In developing the scientific knowledge base, this dissertation defines a systematic general representation of single and multiple mandrel spool-packaged SMA actuators and provides tools for their analysis, understanding, and synthesis. A quasi-static analytical model distills the underlying mechanics down to the three effects of friction, bending, and binding, which enables prediction of the behavior of generic spool-packaged SMA actuators with specifiable geometric, loading, frictional, and SMA material parameters. An extensive experimental and simulation-based parameter study establishes the necessary understanding of how primary design tradeoffs between performance, packaging, and cost are governed by the underlying mechanics of spooled actuators. A design methodology outlines a systematic approach to synthesizing high performance SMA wire actuators with mitigated material, power, and packaging costs and compact, customizable form factors. By examining the multi-faceted connections between performance, packaging, and cost, this dissertation builds a knowledge base that goes beyond implementing SMA actuators for particular applications. Rather, it provides a well-developed strategy for realizing the advantages of SMA actuation for a broadened range of applications, thereby enabling opportunities for new functionality and capabilities in industry.

The AOP framework and causality: Meeting chemical risk ...

EPA Pesticide Factsheets

Chemical safety assessments are expanding from a focus on a few chemicals (or chemical mixtures) to the broader “universe” of thousands, if not hundreds of thousands of substances that potentially could impact humans or the environment. This is exemplified in regulatory activities such as the REACH program in Europe, or the recent reauthorization of TSCA in the US, which require consideration of the potential impacts of a much greater number of chemicals than in the past. The data needed to address these types of legislated mandates cannot realistically be obtained solely through using the whole animal testing approaches historically employed for chemical risk assessment. Rather, there needs to be an increased emphasis on cost-effective tools that enable robust prediction of potential chemical impacts when empirical data are lacking. Concurrent with the realization that predictive methods will need to play an increasingly prominent role in regulatory toxicology has been the recent explosion in technology in the biological sciences enabling collection of large amounts of pathway-based molecular and biochemical data. For example, genomic techniques and high-throughput (robotic-based) in vitro testing enable the generation of knowledge concerning the effects of chemical perturbation on biological systems in an increasingly efficient and rapid manner. However, a pressing need stemming from these technological advances is the ability to actually apply th

Exploring the Possibilities: Earth and Space Science Missions in the Context of Exploration

NASA Technical Reports Server (NTRS)

Pfarr, Barbara; Calabrese, Michael; Kirkpatrick, James; Malay, Jonathan T.

2006-01-01

According to Dr. Edward J. Weiler, Director of the Goddard Space Flight Center, "Exploration without science is tourism". At the American Astronautical Society's 43rd Annual Robert H. Goddard Memorial Symposium it was quite apparent to all that NASA's current Exploration Initiative is tightly coupled to multiple scientific initiatives: exploration will enable new science and science will enable exploration. NASA's Science Mission Directorate plans to develop priority science missions that deliver science that is vital, compelling and urgent. This paper will discuss the theme of the Goddard Memorial Symposium that science plays a key role in exploration. It will summarize the key scientific questions and some of the space and Earth science missions proposed to answer them, including the Mars and Lunar Exploration Programs, the Beyond Einstein and Navigator Programs, and the Earth-Sun System missions. It will also discuss some of the key technologies that will enable these missions, including the latest in instruments and sensors, large space optical system technologies and optical communications, and briefly discuss developments and achievements since the Symposium. Throughout history, humans have made the biggest scientific discoveries by visiting unknown territories; by going to the Moon and other planets and by seeking out habitable words, NASA is continuing humanity's quest for scientific knowledge.

Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9.

PubMed

Ben Jehuda, Ronen; Shemer, Yuval; Binah, Ofer

2018-06-01

The development of the reprogramming technology led to generation of induced Pluripotent Stem Cells (iPSC) from a variety of somatic cells. Ever since, fast growing knowledge of different efficient protocols enabled the differentiation of these iPSCs into different cells types utilized for disease modeling. Indeed, iPSC-derived cells have been increasingly used for investigating molecular and cellular pathophysiological mechanisms underlying inherited diseases. However, a major barrier in the field of iPSC-based disease modeling relies on discriminating between the effects of the causative mutation and the genetic background of these cells. In the past decade, researchers have made great improvement in genome editing techniques, with one of the latest being CRISPR/Cas9. Using a single non-sequence specific protein combined with a small guiding RNA molecule, this state-of-the-art approach enables modifications of genes with high efficiency and accuracy. By so doing, this technique enables the generation of isogenic controls or isogenic mutated cell lines in order to focus on the pathologies caused by a specific mutation. In this article, we review the latest studies combining iPSC and CRISPR/Cas9 technologies for the investigation of the molecular and cellular mechanisms underlying inherited diseases including immunological, metabolic, hematological, neurodegenerative and cardiac diseases.

Strategies and methods for aligning current and best medical practices. The role of information technologies.

PubMed

Schneider, E C; Eisenberg, J M

1998-05-01

Rapid change in American medicine requires that physicians adjust established behaviors and acquire new skills. In this article, we address three questions: What do we know about how to change physicians' practices? How can physicians take advantage of new and evolving information technologies that are likely to have an impact on the future practice of medicine? and What strategic educational interventions will best enable physicians to show competencies in information management and readiness to change practice? We outline four guiding principles for incorporating information systems tools into both medical education and practice, and we make eight recommendations for the development of a new medical school curriculum. This curriculum will produce a future medical practitioner who is capable of using information technologies to systematically measure practice performance, appropriateness, and effectiveness while updating knowledge efficiently.

A methodology for uncertainty quantification in quantitative technology valuation based on expert elicitation

NASA Astrophysics Data System (ADS)

Akram, Muhammad Farooq Bin

The management of technology portfolios is an important element of aerospace system design. New technologies are often applied to new product designs to ensure their competitiveness at the time they are introduced to market. The future performance of yet-to- be designed components is inherently uncertain, necessitating subject matter expert knowledge, statistical methods and financial forecasting. Estimates of the appropriate parameter settings often come from disciplinary experts, who may disagree with each other because of varying experience and background. Due to inherent uncertain nature of expert elicitation in technology valuation process, appropriate uncertainty quantification and propagation is very critical. The uncertainty in defining the impact of an input on performance parameters of a system makes it difficult to use traditional probability theory. Often the available information is not enough to assign the appropriate probability distributions to uncertain inputs. Another problem faced during technology elicitation pertains to technology interactions in a portfolio. When multiple technologies are applied simultaneously on a system, often their cumulative impact is non-linear. Current methods assume that technologies are either incompatible or linearly independent. It is observed that in case of lack of knowledge about the problem, epistemic uncertainty is the most suitable representation of the process. It reduces the number of assumptions during the elicitation process, when experts are forced to assign probability distributions to their opinions without sufficient knowledge. Epistemic uncertainty can be quantified by many techniques. In present research it is proposed that interval analysis and Dempster-Shafer theory of evidence are better suited for quantification of epistemic uncertainty in technology valuation process. Proposed technique seeks to offset some of the problems faced by using deterministic or traditional probabilistic approaches for uncertainty propagation. Non-linear behavior in technology interactions is captured through expert elicitation based technology synergy matrices (TSM). Proposed TSMs increase the fidelity of current technology forecasting methods by including higher order technology interactions. A test case for quantification of epistemic uncertainty on a large scale problem of combined cycle power generation system was selected. A detailed multidisciplinary modeling and simulation environment was adopted for this problem. Results have shown that evidence theory based technique provides more insight on the uncertainties arising from incomplete information or lack of knowledge as compared to deterministic or probability theory methods. Margin analysis was also carried out for both the techniques. A detailed description of TSMs and their usage in conjunction with technology impact matrices and technology compatibility matrices is discussed. Various combination methods are also proposed for higher order interactions, which can be applied according to the expert opinion or historical data. The introduction of technology synergy matrix enabled capturing the higher order technology interactions, and improvement in predicted system performance.

Supporting students' knowledge integration with technology-enhanced inquiry curricula

NASA Astrophysics Data System (ADS)

Chiu, Jennifer Lopseen

Dynamic visualizations of scientific phenomena have the potential to transform how students learn and understand science. Dynamic visualizations enable interaction and experimentation with unobservable atomic-level phenomena. A series of studies clarify the conditions under which embedding dynamic visualizations in technology-enhanced inquiry instruction can help students develop robust and durable chemistry knowledge. Using the knowledge integration perspective, I designed Chemical Reactions, a technology-enhanced curriculum unit, with a partnership of teachers, educational researchers, and chemists. This unit guides students in an exploration of how energy and chemical reactions relate to climate change. It uses powerful dynamic visualizations to connect atomic level interactions to the accumulation of greenhouse gases. The series of studies were conducted in typical classrooms in eleven high schools across the country. This dissertation describes four studies that contribute to understanding of how visualizations can be used to transform chemistry learning. The efficacy study investigated the impact of the Chemical Reactions unit compared to traditional instruction using pre-, post- and delayed posttest assessments. The self-monitoring study used self-ratings in combination with embedded assessments to explore how explanation prompts help students learn from dynamic visualizations. The self-regulation study used log files of students' interactions with the learning environment to investigate how external feedback and explanation prompts influence students' exploration of dynamic visualizations. The explanation study compared specific and general explanation prompts to explore the processes by which explanations benefit learning with dynamic visualizations. These studies delineate the conditions under which dynamic visualizations embedded in inquiry instruction can enhance student outcomes. The studies reveal that visualizations can be deceptively clear, deterring learners from exploring details. Asking students to generate explanations helps them realize what they don't understand and can spur students to revisit visualizations to remedy gaps in their knowledge. The studies demonstrate that science instruction focused on complex topics can succeed by combining visualizations with generative activities to encourage knowledge integration. Students are more successful at monitoring their progress and remedying gaps in knowledge when required to distinguish among alternative explanations. The results inform the design of technology-enhanced science instruction for typical classrooms.

Recent advances in inkjet dispensing technologies: applications in drug discovery.

PubMed

Zhu, Xiangcheng; Zheng, Qiang; Yang, Hu; Cai, Jin; Huang, Lei; Duan, Yanwen; Xu, Zhinan; Cen, Peilin

2012-09-01

Inkjet dispensing technology is a promising fabrication methodology widely applied in drug discovery. The automated programmable characteristics and high-throughput efficiency makes this approach potentially very useful in miniaturizing the design patterns for assays and drug screening. Various custom-made inkjet dispensing systems as well as specialized bio-ink and substrates have been developed and applied to fulfill the increasing demands of basic drug discovery studies. The incorporation of other modern technologies has further exploited the potential of inkjet dispensing technology in drug discovery and development. This paper reviews and discusses the recent developments and practical applications of inkjet dispensing technology in several areas of drug discovery and development including fundamental assays of cells and proteins, microarrays, biosensors, tissue engineering, basic biological and pharmaceutical studies. Progression in a number of areas of research including biomaterials, inkjet mechanical systems and modern analytical techniques as well as the exploration and accumulation of profound biological knowledge has enabled different inkjet dispensing technologies to be developed and adapted for high-throughput pattern fabrication and miniaturization. This in turn presents a great opportunity to propel inkjet dispensing technology into drug discovery.

Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data

PubMed Central

2014-01-01

Background High-throughput omics technologies have enabled the measurement of many genes or metabolites simultaneously. The resulting high dimensional experimental data poses significant challenges to transcriptomics and metabolomics data analysis methods, which may lead to spurious instead of biologically relevant results. One strategy to improve the results is the incorporation of prior biological knowledge in the analysis. This strategy is used to reduce the solution space and/or to focus the analysis on biological meaningful regions. In this article, we review a selection of these methods used in transcriptomics and metabolomics. We combine the reviewed methods in three groups based on the underlying mathematical model: exploratory methods, supervised methods and estimation of the covariance matrix. We discuss which prior knowledge has been used, how it is incorporated and how it modifies the mathematical properties of the underlying methods. PMID:25033193

The Innovation Deficit in Urban Water: The Need for an Integrated Perspective on Institutions, Organizations, and Technology.

PubMed

Kiparsky, Michael; Sedlak, David L; Thompson, Barton H; Truffer, Bernhard

2013-08-01

Interaction between institutional change and technological change poses important constraints on transitions of urban water systems to a state that can meet future needs. Research on urban water and other technology-dependent systems provides insights that are valuable to technology researchers interested in assuring that their efforts will have an impact. In the context of research on institutional change, innovation is the development, application, diffusion, and utilization of new knowledge and technology. This definition is intentionally inclusive: technological innovation will play a key role in reinvention of urban water systems, but is only part of what is necessary. Innovation usually depends on context, such that major changes to infrastructure include not only the technological inventions that drive greater efficiencies and physical transformations of water treatment and delivery systems, but also the political, cultural, social, and economic factors that hinder and enable such changes. On the basis of past and present changes in urban water systems, institutional innovation will be of similar importance to technological innovation in urban water reinvention. To solve current urban water infrastructure challenges, technology-focused researchers need to recognize the intertwined nature of technologies and institutions and the social systems that control change.

Semantic Service Design for Collaborative Business Processes in Internetworked Enterprises

NASA Astrophysics Data System (ADS)

Bianchini, Devis; Cappiello, Cinzia; de Antonellis, Valeria; Pernici, Barbara

Modern collaborating enterprises can be seen as borderless organizations whose processes are dynamically transformed and integrated with the ones of their partners (Internetworked Enterprises, IE), thus enabling the design of collaborative business processes. The adoption of Semantic Web and service-oriented technologies for implementing collaboration in such distributed and heterogeneous environments promises significant benefits. IE can model their own processes independently by using the Software as a Service paradigm (SaaS). Each enterprise maintains a catalog of available services and these can be shared across IE and reused to build up complex collaborative processes. Moreover, each enterprise can adopt its own terminology and concepts to describe business processes and component services. This brings requirements to manage semantic heterogeneity in process descriptions which are distributed across different enterprise systems. To enable effective service-based collaboration, IEs have to standardize their process descriptions and model them through component services using the same approach and principles. For enabling collaborative business processes across IE, services should be designed following an homogeneous approach, possibly maintaining a uniform level of granularity. In the paper we propose an ontology-based semantic modeling approach apt to enrich and reconcile semantics of process descriptions to facilitate process knowledge management and to enable semantic service design (by discovery, reuse and integration of process elements/constructs). The approach brings together Semantic Web technologies, techniques in process modeling, ontology building and semantic matching in order to provide a comprehensive semantic modeling framework.

Dengue Vaccines: A Perspective from the Point of View of Intellectual Property.

PubMed

da Veiga, Claudimar Pereira; da Veiga, Cássia Rita Pereira; Del Corso, Jansen Maia; da Silva, Wesley Vieira

2015-08-12

Dengue is a serious infectious disease and a growing public health problem in many tropical and sub-tropical countries. To control this neglected tropical disease (NTD), vaccines are likely to be the most cost-effective solution. This study analyzed dengue vaccines from both a historical and longitudinal perspective by using patent data, evaluating the geographic and time coverage of innovations, the primary patent holders, the network of cooperation and partnership for vaccine research and development (R &amp; D), the flow of knowledge and the technological domain involved. This study can be seen as an example of the use of patent information to inform policy discussions, strategic research planning, and technology transfer. The results show that 93% of patents were granted since 2000, the majority belonging to the United States and Europe, although the share of patents from developing countries has increased. Unlike another NTDs, there is great participation of private companies in R &amp; D of dengue vaccines and partnerships and collaboration between public and private companies. Finally, in this study, the main holders showed high knowledge absorption and generated capabilities. Therefore, this issue suggests that to overcome the difficulty of translational R &amp; D it is necessary to stimulate the generation of knowledge and relevant scientific research, to enable the productive sector to have the capacity to absorb knowledge, to turn it into innovation, and to articulate partnerships and collaboration.

Dengue Vaccines: A Perspective from the Point of View of Intellectual Property

PubMed Central

Pereira da Veiga, Claudimar; Pereira da Veiga, Cássia Rita; Del Corso, Jansen Maia; Vieira da Silva, Wesley

2015-01-01

Dengue is a serious infectious disease and a growing public health problem in many tropical and sub-tropical countries. To control this neglected tropical disease (NTD), vaccines are likely to be the most cost-effective solution. This study analyzed dengue vaccines from both a historical and longitudinal perspective by using patent data, evaluating the geographic and time coverage of innovations, the primary patent holders, the network of cooperation and partnership for vaccine research and development (R & D), the flow of knowledge and the technological domain involved. This study can be seen as an example of the use of patent information to inform policy discussions, strategic research planning, and technology transfer. The results show that 93% of patents were granted since 2000, the majority belonging to the United States and Europe, although the share of patents from developing countries has increased. Unlike another NTDs, there is great participation of private companies in R & D of dengue vaccines and partnerships and collaboration between public and private companies. Finally, in this study, the main holders showed high knowledge absorption and generated capabilities. Therefore, this issue suggests that to overcome the difficulty of translational R & D it is necessary to stimulate the generation of knowledge and relevant scientific research, to enable the productive sector to have the capacity to absorb knowledge, to turn it into innovation, and to articulate partnerships and collaboration. PMID:26274968

Social Media, Power, and the Future of VBAC.

PubMed

Romano, Amy M; Gerber, Hilary; Andrews, Desirre

2010-01-01

The Internet has been called a disruptive technology because it has shifted power and altered the economics of doing business, whether that business is selling books or providing health care. Social media have accelerated the pace of disruption by enabling interactive information sharing and blurring the lines between the "producers" and "consumers" of knowledge, goods, and services. In the wake of the National Institutes of Health Consensus Development Conference on Vaginal Birth After Cesarean (VBAC) and major national recommendations for maternity care reform, activated, engaged consumers face an unprecedented opportunity to drive meaningful changes in VBAC access and safety. This article examines the role of social networks in informing women about VBAC, producing low-cost, accessible decision aids, and enabling multi-stakeholder collaborations toward workable solutions that remove barriers women face in accessing VBAC.

Developing Mixed Reality Educational Applications: The Virtual Touch Toolkit.

PubMed

Mateu, Juan; Lasala, María José; Alamán, Xavier

2015-08-31

In this paper, we present Virtual Touch, a toolkit that allows the development of educational activities through a mixed reality environment such that, using various tangible elements, the interconnection of a virtual world with the real world is enabled. The main goal of Virtual Touch is to facilitate the installation, configuration and programming of different types of technologies, abstracting the creator of educational applications from the technical details involving the use of tangible interfaces and virtual worlds. Therefore, it is specially designed to enable teachers to themselves create educational activities for their students in a simple way, taking into account that teachers generally lack advanced knowledge in computer programming and electronics. The toolkit has been used to develop various educational applications that have been tested in two secondary education high schools in Spain.

DEApp: an interactive web interface for differential expression analysis of next generation sequence data.

PubMed

Li, Yan; Andrade, Jorge

2017-01-01

A growing trend in the biomedical community is the use of Next Generation Sequencing (NGS) technologies in genomics research. The complexity of downstream differential expression (DE) analysis is however still challenging, as it requires sufficient computer programing and command-line knowledge. Furthermore, researchers often need to evaluate and visualize interactively the effect of using differential statistical and error models, assess the impact of selecting different parameters and cutoffs, and finally explore the overlapping consensus of cross-validated results obtained with different methods. This represents a bottleneck that slows down or impedes the adoption of NGS technologies in many labs. We developed DEApp, an interactive and dynamic web application for differential expression analysis of count based NGS data. This application enables models selection, parameter tuning, cross validation and visualization of results in a user-friendly interface. DEApp enables labs with no access to full time bioinformaticians to exploit the advantages of NGS applications in biomedical research. This application is freely available at https://yanli.shinyapps.io/DEAppand https://gallery.shinyapps.io/DEApp.

Do It Yourself (DIY) Earth Science Collaboratories Using Best Practices and Breakthrough Technologies

NASA Astrophysics Data System (ADS)

Stephan, E.

2017-12-01

The objective of published earth science study data results and literature on the Web should be to provide a means to integrate discoverable science resources through an open collaborative-Web. At the core of any open science collaborative infrastructure is the ability to discover, manage and ultimately use relevant data accessible to the collaboration. Equally important are the relationships between people, applications, services, and publications, which capture critical contextual knowledge that enable their effective use. While contributions of either irreproducible or costly data can be a great asset the inability of users being able to use the data intelligently or make sense of it, makes these investments not usable. An ability to describe ad-hoc discoverable usage methodologies, provide feedback to data producers, and identify and cite data in a systematic way by leveraging existing Web-enabled off the shelf technology is needed. Fortunately many break-through advancements in data publication best practices and government, open source, and commercial investments support consumers who can provide feedback, share experiences, and contribute back to the earth science ecosystem.

A Brief Chronicle of CD4 as a Biomarker for HIV/AIDS: A Tribute to the Memory of John L. Fahey.

PubMed

Kagan, Jonathan M; Sanchez, Ana M; Landay, Alan; Denny, Thomas N

Foundational cellular immunology research of the 1960s and 1970s, together with the advent of monoclonal antibodies and flow cytometry, provided the knowledge base and the technological capability that enabled the elucidation of the role of CD4 T cells in HIV infection. Research identifying the sources and magnitude of variation in CD4 measurements, standardized reagents and protocols, and the development of clinical flow cytometers all contributed to the feasibility of widespread CD4 testing. Cohort studies and clinical trials provided the context for establishing the utility of CD4 for prognosis in HIV-infected persons, initial assessment of in vivo antiretroviral drug activity, and as a surrogate marker for clinical outcome in antiretroviral therapeutic trials. Even with sensitive HIV viral load measurement, CD4 cell counting is still utilized in determining antiretroviral therapy eligibility and time to initiate therapy. New point of care technologies are helping both to lower the cost of CD4 testing and enable its use in HIV test and treat programs around the world.

Strategic Computing Computer Vision: Taking Image Understanding To The Next Plateau

NASA Astrophysics Data System (ADS)

Simpson, R. L., Jr.

1987-06-01

The overall objective of the Strategic Computing (SC) Program of the Defense Advanced Research Projects Agency (DARPA) is to develop and demonstrate a new generation of machine intelligence technology which can form the basis for more capable military systems in the future and also maintain a position of world leadership for the US in computer technology. Begun in 1983, SC represents a focused research strategy for accelerating the evolution of new technology and its rapid prototyping in realistic military contexts. Among the very ambitious demonstration prototypes being developed within the SC Program are: 1) the Pilot's Associate which will aid the pilot in route planning, aerial target prioritization, evasion of missile threats, and aircraft emergency safety procedures during flight; 2) two battle management projects one for the for the Army, which is just getting started, called the AirLand Battle Management program (ALBM) which will use knowledge-based systems technology to assist in the generation and evaluation of tactical options and plans at the Corps level; 3) the other more established program for the Navy is the Fleet Command Center Battle Management Program (FCCBIVIP) at Pearl Harbor. The FCCBMP is employing knowledge-based systems and natural language technology in a evolutionary testbed situated in an operational command center to demonstrate and evaluate intelligent decision-aids which can assist in the evaluation of fleet readiness and explore alternatives during contingencies; and 4) the Autonomous Land Vehicle (ALV) which integrates in a major robotic testbed the technologies for dynamic image understanding, knowledge-based route planning with replanning during execution, hosted on new advanced parallel architectures. The goal of the Strategic Computing computer vision technology base (SCVision) is to develop generic technology that will enable the construction of complete, robust, high performance image understanding systems to support a wide range of DoD applications. Possible applications include autonomous vehicle navigation, photointerpretation, smart weapons, and robotic manipulation. This paper provides an overview of the technical and program management plans being used in evolving this critical national technology.

Biofuel alternatives to ethanol: pumping the microbial well

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fortman, J. L.; Chhabra, Swapnil; Mukhopadhyay, Aindrila

Engineered microorganisms are currently used for the production of food products, pharmaceuticals, ethanol fuel and more. Even so, the enormous potential of this technology has yet to be fully exploited. The need for sustainable sources of transportation fuels has gener-ated a tremendous interest in technologies that enable biofuel production. Decades of work have produced a considerable knowledge-base for the physiology and pathway engineering of microbes, making microbial engineering an ideal strategy for producing biofuel. Although ethanol currently dominates the biofuel mar-ket, some of its inherent physical properties make it a less than ideal product. To highlight additional options, we reviewmore » advances in microbial engineering for the production of other potential fuel molecules, using a variety of biosynthetic pathways.« less

Biofuel alternatives to ethanol: pumping the microbial well

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fortman, J.L.; Chhabra, Swapnil; Mukhopadhyay, Aindrila

2009-08-19

Engineered microorganisms are currently used for the production of food products, pharmaceuticals, ethanol fuel and more. Even so, the enormous potential of this technology has yet to be fully exploited. The need for sustainable sources of transportation fuels has generated a tremendous interest in technologies that enable biofuel production. Decades of work have produced a considerable knowledge-base for the physiology and pathway engineering of microbes, making microbial engineering an ideal strategy for producing biofuel. Although ethanol currently dominates the biofuel market, some of its inherent physical properties make it a less than ideal product. To highlight additional options, we reviewmore » advances in microbial engineering for the production of other potential fuel molecules, using a variety of biosynthetic pathways.« less

An Independent Scientific Assessment of Well Stimulation in California Volume III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jane C.S. Long; Laura C. Feinstein; Birkholzer, Jens

This study is issued in three volumes. Volume I, issued in January 2015, describes how well stimulation technologies work, how and where operators deploy these technologies for oil and gas production in California, and where they might enable production in the future. Volume II, issued in July 2015, discusses how well stimulation could affect water, atmosphere, seismic activity, wildlife and vegetation, and human health. Volume II reviews available data, and identifies knowledge gaps and alternative practices that could avoid or mitigate these possible impacts. Volume III, this volume, presents case studies that assess environmental issues and qualitative risks for specificmore » geographic regions. The Summary Report summarizes key findings, conclusions and recommendations of all three volumes.« less

An Independent Scientific Assessment of Well Stimulation in California Volume II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jane C.S. Long; Laura C. Feinstein; Corinne E. Bachmann

This study is issued in three volumes. Volume I, issued in January 2015, describes how well stimulation technologies work, how and where operators deploy these technologies for oil and gas production in California, and where they might enable production in the future. Volume II, the present volume, discusses how well stimulation could affect water, atmosphere, seismic activity, wildlife and vegetation, and human health. Volume II reviews available data, and identifies knowledge gaps and alternative practices that could avoid or mitigate these possible impacts. Volume III, also issued in July 2015, presents case studies that assess environmental issues and qualitative risksmore » for specific geographic regions. A final Summary Report summarizes key findings, conclusions and recommendations of all three volumes.« less

XML-based data model and architecture for a knowledge-based grid-enabled problem-solving environment for high-throughput biological imaging.

PubMed

Ahmed, Wamiq M; Lenz, Dominik; Liu, Jia; Paul Robinson, J; Ghafoor, Arif

2008-03-01

High-throughput biological imaging uses automated imaging devices to collect a large number of microscopic images for analysis of biological systems and validation of scientific hypotheses. Efficient manipulation of these datasets for knowledge discovery requires high-performance computational resources, efficient storage, and automated tools for extracting and sharing such knowledge among different research sites. Newly emerging grid technologies provide powerful means for exploiting the full potential of these imaging techniques. Efficient utilization of grid resources requires the development of knowledge-based tools and services that combine domain knowledge with analysis algorithms. In this paper, we first investigate how grid infrastructure can facilitate high-throughput biological imaging research, and present an architecture for providing knowledge-based grid services for this field. We identify two levels of knowledge-based services. The first level provides tools for extracting spatiotemporal knowledge from image sets and the second level provides high-level knowledge management and reasoning services. We then present cellular imaging markup language, an extensible markup language-based language for modeling of biological images and representation of spatiotemporal knowledge. This scheme can be used for spatiotemporal event composition, matching, and automated knowledge extraction and representation for large biological imaging datasets. We demonstrate the expressive power of this formalism by means of different examples and extensive experimental results.

Formalized landscape models for surveying and modelling tasks

NASA Astrophysics Data System (ADS)

Löwner, Marc-Oliver

2010-05-01

We present a formalization of main geomorphic landscape models, mainly the concept of slopes, to clarify the needs and potentials of surveying technologies and modelling approaches. Using the Unified Modelling Language (UML) it is implemented as a exchangeable Geography Markup Language (GML3) -based application schema and therefore supports shared measurement campaigns. Today, knowledge in Geomorphology is given synoptically in textbooks in a more or less lyrical way. This knowledge is hard to implement for the use of modelling algorithms or data storage and sharing questions. On the other hand physical based numerical modelling and high resolution surveying technologies enable us to investigate case scenarios within small scales. Bringing together such approaches and organizing our data in an appropriate way will need the formalization of the concepts and knowledge that is archived in the science of geomorphology. The main problem of comparing research results in geomorphology but is that the objects under investigation are composed of 3-dimensional geometries that change in time due to processes of material fluxes, e. g. soil erosion or mass movements. They have internal properties, e. g. soil texture or bulk density, that determine the effectiveness of these processes but are under change as well. The presented application schema is available on the Internet and therefore a first step to enable researchers to share information using an OGC's Web feature service. In this vein comparing modelling results of landscape evolution with results of other scientist's observations is possible. Compared to prevalent data concepts the model presented makes it possible to store information about landforms, their geometry and the characteristics in more detail. It allows to represent the 3D-geometry, the set of material properties and the genesis of a landform by associating processes to a geoobject. Thus, time slices of a geomorphic system can be represented as well as scenarios of landscape modelling. Commercial GI-software is not adapted to the needs of the science of geomorphology. Therefore the development of an application model i. e. a formal description of semantics is imperative to partake in technologies like Web Feature Services supporting interoperable data transfer.

FuturICT: Participatory computing to understand and manage our complex world in a more sustainable and resilient way

NASA Astrophysics Data System (ADS)

Helbing, D.; Bishop, S.; Conte, R.; Lukowicz, P.; McCarthy, J. B.

2012-11-01

We have built particle accelerators to understand the forces that make up our physical world. Yet, we do not understand the principles underlying our strongly connected, techno-socio-economic systems. We have enabled ubiquitous Internet connectivity and instant, global information access. Yet we do not understand how it impacts our behavior and the evolution of society. To fill the knowledge gaps and keep up with the fast pace at which our world is changing, a Knowledge Accelerator must urgently be created. The financial crisis, international wars, global terror, the spreading of diseases and cyber-crime as well as demographic, technological and environmental change demonstrate that humanity is facing serious challenges. These problems cannot be solved within the traditional paradigms. Moving our attention from a component-oriented view of the world to an interaction-oriented view will allow us to understand the complex systems we have created and the emergent collective phenomena characterising them. This paradigm shift will enable new solutions to long-standing problems, very much as the shift from a geocentric to a heliocentric worldview has facilitated modern physics and the ability to launch satellites. The FuturICT flagship project will develop new science and technology to manage our future in a complex, strongly connected world. For this, it will combine the power of information and communication technology (ICT) with knowledge from the social and complexity sciences. ICT will provide the data to boost the social sciences into a new era. Complexity science will shed new light on the emergent phenomena in socially interactive systems, and the social sciences will provide a better understanding of the opportunities and risks of strongly networked systems, in particular future ICT systems. Hence, the envisaged FuturICT flagship will create new methods and instruments to tackle the challenges of the 21st century. FuturICT could indeed become one of the most important scientific endeavours ever, by revealing the principles that make socially interactive systems work well, by inspiring the creation of new platforms to explore our possible futures, and by initiating an era of social and socio-inspired innovations.

A survey of enabling technologies in synthetic biology

PubMed Central

2013-01-01

Background Realizing constructive applications of synthetic biology requires continued development of enabling technologies as well as policies and practices to ensure these technologies remain accessible for research. Broadly defined, enabling technologies for synthetic biology include any reagent or method that, alone or in combination with associated technologies, provides the means to generate any new research tool or application. Because applications of synthetic biology likely will embody multiple patented inventions, it will be important to create structures for managing intellectual property rights that best promote continued innovation. Monitoring the enabling technologies of synthetic biology will facilitate the systematic investigation of property rights coupled to these technologies and help shape policies and practices that impact the use, regulation, patenting, and licensing of these technologies. Results We conducted a survey among a self-identifying community of practitioners engaged in synthetic biology research to obtain their opinions and experiences with technologies that support the engineering of biological systems. Technologies widely used and considered enabling by survey participants included public and private registries of biological parts, standard methods for physical assembly of DNA constructs, genomic databases, software tools for search, alignment, analysis, and editing of DNA sequences, and commercial services for DNA synthesis and sequencing. Standards and methods supporting measurement, functional composition, and data exchange were less widely used though still considered enabling by a subset of survey participants. Conclusions The set of enabling technologies compiled from this survey provide insight into the many and varied technologies that support innovation in synthetic biology. Many of these technologies are widely accessible for use, either by virtue of being in the public domain or through legal tools such as non-exclusive licensing. Access to some patent protected technologies is less clear and use of these technologies may be subject to restrictions imposed by material transfer agreements or other contract terms. We expect the technologies considered enabling for synthetic biology to change as the field advances. By monitoring the enabling technologies of synthetic biology and addressing the policies and practices that impact their development and use, our hope is that the field will be better able to realize its full potential. PMID:23663447

How Does Technology-Enabled Active Learning Affect Undergraduate Students' Understanding of Electromagnetism Concepts?

ERIC Educational Resources Information Center

Dori, Yehudit Judy; Belcher, John

2005-01-01

Educational technology supports meaningful learning and enables the presentation of spatial and dynamic images, which portray relationships among complex concepts. The Technology-Enabled Active Learning (TEAL) Project at the Massachusetts Institute of Technology (MIT) involves media-rich software for simulation and visualization in freshman…

Open Science in the Cloud: Towards a Universal Platform for Scientific and Statistical Computing

NASA Astrophysics Data System (ADS)

Chine, Karim

The UK, through the e-Science program, the US through the NSF-funded cyber infrastructure and the European Union through the ICT Calls aimed to provide "the technological solution to the problem of efficiently connecting data, computers, and people with the goal of enabling derivation of novel scientific theories and knowledge".1 The Grid (Foster, 2002; Foster; Kesselman, Nick, & Tuecke, 2002), foreseen as a major accelerator of discovery, didn't meet the expectations it had excited at its beginnings and was not adopted by the broad population of research professionals. The Grid is a good tool for particle physicists and it has allowed them to tackle the tremendous computational challenges inherent to their field. However, as a technology and paradigm for delivering computing on demand, it doesn't work and it can't be fixed. On one hand, "the abstractions that Grids expose - to the end-user, to the deployers and to application developers - are inappropriate and they need to be higher level" (Jha, Merzky, & Fox), and on the other hand, academic Grids are inherently economically unsustainable. They can't compete with a service outsourced to the Industry whose quality and price would be driven by market forces. The virtualization technologies and their corollary, the Infrastructure-as-a-Service (IaaS) style cloud, hold the promise to enable what the Grid failed to deliver: a sustainable environment for computational sciences that would lower the barriers for accessing federated computational resources, software tools and data; enable collaboration and resources sharing and provide the building blocks of a ubiquitous platform for traceable and reproducible computational research.

Education in care and technology, a facilitator of interdisciplinary research and development.

PubMed

Willems, Charles G; Sponselee, Anne-Mie; Verkerke, Margreet Michel; Sirkka, Andrew; Saarni, Lea; Castello Branco, Miguel; de Witte, Luc

2015-01-01

Application of technology in care is hindered by two factors; a critical attitude of care professionals towards the use of technology as part of care delivery and a lack of knowledge of care practice by technology developers. Technological developments may provide adequate solutions to support care provision. The principles of user centred design and development, traditionally used in the development of assistive technology, may provide powerful tools to support care provision. Interdisciplinary research will be needed to take full benefit. Educational programs to support this development are lacking. Main content of this paper: Six organisations of higher education have taken the initiative to organize a training program to support professionals active in the care or in the technology domain that enables them to become involved in interdisciplinary research and development. a European program to educate a professional master in Care and Technology has been developed and is described in this paper. Accreditation of the program is initiated. Alumni of such a program may form a European network of professionals that are active in developing new solutions to support people with special needs and contribute to the generation of new business.

BioServe space technologies: A NASA Center for the Commercial Development of Space

NASA Technical Reports Server (NTRS)

1992-01-01

BioServe Space Technologies, a NASA Center for the Commercial Development of Space (CCDS), was established in 1987. As is characteristic of each CCDS designated by NASA, the goals of this commercial center are aimed at stimulating high technology research that takes advantage of the space environment and at leading in the development of new products and services which have commercial potential or that contribute to possible new commercial ventures. BioServe's efforts in these areas focus upon space life science studies and the development of enabling devices that will facilitate ground-based experiments as well as the conversion of such to the microgravity environment. A direct result of BioServe's hardware development and life sciences studies is the training of the next generation of bioengineers who will be knowledgeable and comfortable working with the challenges of the space frontier.

Modeling of human movement monitoring using Bluetooth Low Energy technology.

PubMed

Mokhtari, G; Zhang, Q; Karunanithi, M

2015-01-01

Bluetooth Low Energy (BLE) is a wireless communication technology which can be used to monitor human movements. In this monitoring system, a BLE signal scanner scans signal strength of BLE tags carried by people, to thus infer human movement patterns within its monitoring zone. However to the extent of our knowledge one main aspect of this monitoring system which has not yet been thoroughly investigated in literature is how to build a sound theoretical model, based on tunable BLE communication parameters such as scanning time interval and advertising time interval, to enable the study and design of effective and efficient movement monitoring systems. In this paper, we proposed and developed a statistical model based on Monte-Carlo simulation, which can be utilized to assess impacts of BLE technology parameters in terms of latency and efficiency, on a movement monitoring system, and can thus benefit a more efficient system design.

Health literacy and patient portals.

PubMed

Gu, Yulong; Orr, Martin; Warren, Jim

2015-06-01

Health literacy has been described as the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions. Improving health literacy may serve to promote concordance with therapy, engage patients in their own health care, and improve health outcomes. Patient portal technology aims at enabling patients and families to have easy access to key information in their own medical records and to communicate with their health care providers electronically. However, there is a gap in our understanding of how portals will improve patient outcome. The authors believe patient portal technology presents an opportunity to improve patient concordance with prescribed therapy, if adequate support is provided to equip patients (and family/carers) with the knowledge needed to utilise the health information available via the portals. Research is needed to understand what a health consumer will use patient portals for and how to support a user to realise the technology's potential.

Cancer Moonshot Data and Technology Team: Enabling a National Learning Healthcare System for Cancer to Unleash the Power of Data

PubMed Central

Hsu, ER; Klemm, JD; Kerlavage, AR; Kusnezov, D

2017-01-01

The Cancer Moonshot emphasizes the need to learn from the experiences of cancer patients to positively impact their outcomes, experiences, and qualities of life. To realize this vision, there has been a concerted effort to identify the fundamental building blocks required to establish a National Learning Healthcare System for Cancer, such that relevant data on all cancer patients is accessible, shareable, and contributing to the current state of knowledge of cancer care and outcomes. PMID:28139831

Micromechanics of root development in soil.

PubMed

Dupuy, L X; Mimault, M; Patko, D; Ladmiral, V; Ameduri, B; MacDonald, M P; Ptashnyk, M

2018-04-16

Our understanding of how roots develop in soil may be at the eve of significant transformations. The formidable expansion of imaging technologies enables live observations of the rhizosphere micro-pore architecture at unprecedented resolution. Granular matter physics provides ways to understand the microscopic fluctuations of forces in soils, and the increasing knowledge of plant mechanobiology may shed new lights on how roots perceive soil heterogeneity. This opinion paper exposes how recent scientific achievements may contribute to refresh our views on root growth in heterogeneous environments. Copyright © 2018 Elsevier Ltd. All rights reserved.

Increasing the automation of a 2D-3D registration system.

PubMed

Varnavas, Andreas; Carrell, Tom; Penney, Graeme

2013-02-01

Routine clinical use of 2D-3D registration algorithms for Image Guided Surgery remains limited. A key aspect for routine clinical use of this technology is its degree of automation, i.e., the amount of necessary knowledgeable interaction between the clinicians and the registration system. Current image-based registration approaches usually require knowledgeable manual interaction during two stages: for initial pose estimation and for verification of produced results. We propose four novel techniques, particularly suited to vertebra-based registration systems, which can significantly automate both of the above stages. Two of these techniques are based upon the intraoperative "insertion" of a virtual fiducial marker into the preoperative data. The remaining two techniques use the final registration similarity value between multiple CT vertebrae and a single fluoroscopy vertebra. The proposed methods were evaluated with data from 31 operations (31 CT scans, 419 fluoroscopy images). Results show these methods can remove the need for manual vertebra identification during initial pose estimation, and were also very effective for result verification, producing a combined true positive rate of 100% and false positive rate equal to zero. This large decrease in required knowledgeable interaction is an important contribution aiming to enable more widespread use of 2D-3D registration technology.

The School of Virtual Knocks: Learning from Doing--Without Pain of Mistakes

NASA Technical Reports Server (NTRS)

Darby, Michael

2008-01-01

The present day educational process, as currently practiced, is no longer necessarily synonymous with learning, and the concept of learning is becoming disassociated with knowledge acquisition. True, learning is not accidental, nor is the absence of learning normally by choice. It is the result, intended or otherwise, of decisions made by government, researchers, educators, students, parents, and the wider community. It is underpinned by the quality of teaching, the relevancy of the instruction to the student's world, and the perseverance of the student's desire to learn. It is these choices that are driving the wedge between teaching and learning. The learning outcomes are derived by curriculum developers, educational psychologists, government and industry.Yet as advances in understanding how students learn have been made, the advances in technology, specifically models and simulation, which are able to underpin complex knowledge domains, have been left behind if not ignored. While a majority of stakeholders in education agree that the current educational environment is missing the mark, it is important to underpin those impressions with a basis of knowledge. This paper reviews education in order to foster the conclusion that education must change and that the enabling methodologies and technologies already exist in the form of models and simulation.

Co-care: Producing better health outcome through interactions between patients, care providers and information and communication technology

PubMed Central

2016-01-01

The demands on healthcare are shifting, from caring for patients with acute conditions managed in a single-care episode to caring for patients with chronic and often complex conditions. With this shift comes a recognition that healthcare requires an interaction between patients and care providers, and of the interdependencies between these actors for achieving a positive outcome – that the results are co-produced. This paper introduces co-care, which stresses that the role of healthcare providers is to complement people’s own resources for managing their health so that patients’ and healthcare providers’ resources combined leads to the best possible outcome. This is done using tools and artifacts such as information and communication technology that enable knowledge to be created, shaped, shared and applied across the actors. Thus, in co-care, knowledge is not attributed to a single entity but distributed between them in line with the theory of distributed cognition. To put co-care into practice, several challenges must be addressed. This includes moving from profession-centeredness to patient-centeredness and from approaching care as a transformation of input to products to viewing care as linking needs and knowledge, as well as a substantial attitude and behavior change across healthcare stakeholders.

Development of an Antimicrobial Stewardship-based Infectious Diseases Elective that Incorporates Human Patient Simulation Technology

PubMed Central

Meyer, Susan M.

2014-01-01

Objective. To design an elective for pharmacy students that facilitates antimicrobial stewardship awareness, knowledge, and skill development by solving clinical cases, using human patient simulation technology. Design. The elective was designed for PharmD students to describe principles and functions of stewardship programs, select, evaluate, refine, or redesign patient-specific plans for infectious diseases in the context of antimicrobial stewardship, and propose criteria and stewardship management strategies for an antimicrobial class at a health care institution. Teaching methods included active learning and lectures. Cases of bacterial endocarditis and cryptococcal meningitis were developed that incorporated human patient simulation technology. Assessment. Forty-five pharmacy students completed an antimicrobial stewardship elective between 2010 and 2013. Outcomes were assessed using student perceptions of and performance on rubric-graded assignments. Conclusion. A PharmD elective using active learning, including novel cases conducted with human patient simulation technology, enabled outcomes consistent with those desired of pharmacists assisting in antimicrobial stewardship programs. PMID:25386016

Black liquor gasification integrated in pulp and paper mills: A critical review.

PubMed

Naqvi, M; Yan, J; Dahlquist, E

2010-11-01

Black liquor gasification (BLG) has potential to replace a Tomlinson recovery boiler as an alternative technology to increase safety, flexibility and energy efficiency of pulp and paper mills. This paper presents an extensive literature review of the research and development of various BLG technologies over recent years based on low and high temperature gasification that include SCA-Billerud process, Manufacturing and Technology Conversion International (MTCI) process, direct alkali regeneration system (DARS), BLG with direct causticization, Chemrec BLG system, and catalytic hydrothermal BLG. A few technologies were tested on pilot scale but most of them were abandoned due to technical inferiority and very fewer are now at commercial stage. The drivers for the commercialization of BLG enabling bio-refinery operations at modern pulp mills, co-producing pulp and value added energy products, are discussed. In addition, the potential areas of research and development in BLG required to solve the critical issues and to fill research knowledge gaps are addressed and highlighted. Copyright 2010 Elsevier Ltd. All rights reserved.

A technology-enabled adherence enhancement system for people with bipolar disorder: results from a feasibility and patient acceptance analysis

PubMed Central

Sajatovic, Martha; Davis, Michael S; Cassidy, Kristin A; Nestor, Joseph; Sams, Johnny; Fuentes-Casiano, Edna

2015-01-01

Objective As poor medication adherence is common in bipolar disorder (BD), technology-assisted approaches may help to monitor and enhance adherence. This study evaluated preliminary feasibility, patient satisfaction and effects on adherence, BD knowledge, and BD symptoms associated with the use of a multicomponent technology-assisted adherence enhancement system. Methods This prospective study tested the system in five BD patients over a 15-day period. System components included: 1) an automated pill cap with remote monitoring sensor; 2) a multimedia adherence enhancement program; and 3) a treatment incentive program. This study evaluated system usability, patient satisfaction and effects on adherence (Morisky scale), knowledge (treatment knowledge test [TKT]), and symptoms (internal state scale [ISS]). Results Mean age of the sample was 62 years, 4/5 (80%) Caucasian, and 4/5 (80%) single/divorced or widowed. Most participants (4/5, 80%) were on a single BD medication. Participants had BD for an average of 21 years. Challenges included attaching the pill sensor to standard pharmacy bottles for individuals using very large pill containers or those with multiday pill boxes. Three of five (60%) individuals completed the full 15-day period. Usability scores were high overall. Mean Morisky scores improved. Means on all four subscales of the ISS were all in the direction of improvement. On the TKT, there was a 40% increase in mean scores. Conclusion A multicomponent technology-assisted BD adherence enhancement system is feasible. Challenges include accommodating multiple types of pill containers and monitoring multiple drugs simultaneously. The system can also generate adherence information that is potentially useful for treatment planning. PMID:26089652

Engineering stem cells for future medicine.

PubMed

Ricotti, Leonardo; Menciassi, Arianna

2013-03-01

Despite their great potential in regenerative medicine applications, stem cells (especially pluripotent ones) currently show a limited clinical success, partly due to a lack of biological knowledge, but also due to a lack of specific and advanced technological instruments able to overcome the current boundaries of stem cell functional maturation and safe/effective therapeutic delivery. This paper aims at describing recent insights, current limitations, and future horizons related to therapeutic stem cells, by analyzing the potential of different bioengineering disciplines in bringing stem cells toward a safe clinical use. First, we clarify how and why stem cells should be properly engineered and which could be in a near future the challenges and the benefits connected with this process. Second, we identify different routes toward stem cell differentiation and functional maturation, relying on chemical, mechanical, topographical, and direct/indirect physical stimulation. Third, we highlight how multiscale modeling could strongly support and optimize stem cell engineering. Finally, we focus on future robotic tools that could provide an added value to the extent of translating basic biological knowledge into clinical applications, by developing ad hoc enabling technologies for stem cell delivery and control.

Connecting Coastal Communities with Ocean Science: A Look at Ocean Sense and the Inclusion of Place-based Indigenous Knowledge

NASA Astrophysics Data System (ADS)

McLean, M. A.; Brown, J.; Hoeberechts, M.

2016-02-01

Ocean Networks Canada (ONC), an initiative of the University of Victoria, develops, operates, and maintains cabled ocean observatory systems. Technologies developed on the world-leading NEPTUNE and VENUS observatories have been adapted for small coastal installations called "community observatories," which enable community members to directly monitor conditions in the local ocean environment. In 2014, ONC pioneered an innovative educational program, Ocean Sense: Local observations, global connections, which introduces students and teachers to the technologies installed on community observatories. The program introduces middle and high school students to research methods in biology, oceanography and ocean engineering through hands-on activities. Ocean Sense includes a variety of resources and opportunities to excite students and spark curiosity about the ocean environment. The program encourages students to connect their local observations to global ocean processes and the observations of students in other geographic regions. The connection to place and local relevance of the program is further enhanced through an emphasis on Indigenous and place-based knowledge. ONC is working with coastal Indigenous communities in a collaborative process to include local knowledge, culture, and language in Ocean Sense materials. For this process to meaningful and culturally appropriate, ONC is relying on the guidance and oversight of Indigenous community educators and knowledge holders. Ocean Sense also includes opportunities for Indigenous youth and teachers in remote communities to connect in person, including an annual Ocean Science Symposium and professional development events for teachers. Building a program which embraces multiple perspectives is effective both in making ocean science more relevant to Indigenous students and in linking Indigenous knowledge and place-based knowledge to ocean science.

Re-Engineering the Tropical Rainfall Measuring Mission (TRMM) Satellite Utilizing Goddard Space Flight Center (GSFC) Mission Services Center (GMSEC) Middleware Based Technology to Enable Lights Out Operations and Autonomous Re-Dump of Lost Telemetry Data

NASA Technical Reports Server (NTRS)

Marius, Julio L.; Busch, Jim

2008-01-01

The Tropical Rainfall Measuring Mission (TRMM) spacecraft was launched in November of 1996 in order to obtain unique three dimensional radar cross sectional observations of cloud structures with particular interest in hurricanes. The TRMM mission life was recently extended with current estimates that operations will continue through the 2012-2013 timeframe. Faced with this extended mission profile, the project has embarked on a technology refresh and re-engineering effort. TRMM has recently implemented a re-engineering effort to expand a middleware based messaging architecture to enable fully redundant lights-out of flight operations activities. The middleware approach is based on the Goddard Mission Services Evolution Center (GMSEC) architecture, tools and associated open-source Applications Programming Interface (API). Middleware based messaging systems are useful in spacecraft operations and automation systems because private node based knowledge (such as that within a telemetry and command system) can be broadcast on the middleware messaging bus and hence enable collaborative decisions to be made by multiple subsystems. In this fashion, private data is made public and distributed within the local area network and multiple nodes can remain synchronized with other nodes. This concept is useful in a fully redundant architecture whereby one node is monitoring the processing of the 'prime' node so that in the event of a failure the backup node can assume operations of the prime, without loss of state knowledge. This paper will review and present the experiences, architecture, approach and lessons learned of the TRMM re-engineering effort centered on the GMSEC middleware architecture and tool suite. Relevant information will be presented that relates to the dual redundant parallel nature of the Telemetry and Command (T and C) and Front-End systems and how these systems can interact over a middleware bus to achieve autonomous operations including autonomous commanding to recover missing science data during the same spacecraft contact.

Social Media, Power, and the Future of VBAC

PubMed Central

Romano, Amy M.; Gerber, Hilary; Andrews, Desirre

2010-01-01

The Internet has been called a disruptive technology because it has shifted power and altered the economics of doing business, whether that business is selling books or providing health care. Social media have accelerated the pace of disruption by enabling interactive information sharing and blurring the lines between the “producers” and “consumers” of knowledge, goods, and services. In the wake of the National Institutes of Health Consensus Development Conference on Vaginal Birth After Cesarean (VBAC) and major national recommendations for maternity care reform, activated, engaged consumers face an unprecedented opportunity to drive meaningful changes in VBAC access and safety. This article examines the role of social networks in informing women about VBAC, producing low-cost, accessible decision aids, and enabling multi-stakeholder collaborations toward workable solutions that remove barriers women face in accessing VBAC. PMID:21170180

Developing Mixed Reality Educational Applications: The Virtual Touch Toolkit

PubMed Central

Mateu, Juan; Lasala, María José; Alamán, Xavier

2015-01-01

In this paper, we present Virtual Touch, a toolkit that allows the development of educational activities through a mixed reality environment such that, using various tangible elements, the interconnection of a virtual world with the real world is enabled. The main goal of Virtual Touch is to facilitate the installation, configuration and programming of different types of technologies, abstracting the creator of educational applications from the technical details involving the use of tangible interfaces and virtual worlds. Therefore, it is specially designed to enable teachers to themselves create educational activities for their students in a simple way, taking into account that teachers generally lack advanced knowledge in computer programming and electronics. The toolkit has been used to develop various educational applications that have been tested in two secondary education high schools in Spain. PMID:26334275

Technology Enabled Learning. Symposium.

ERIC Educational Resources Information Center

2002

This document contains three papers on technology-enabled learning and human resource development. Among results found in "Current State of Technology-enabled Learning Programs in Select Federal Government Organizations: a Case Study of Ten Organizations" (Letitia A. Combs) are the following: the dominant delivery method is traditional…

The Innovation Deficit in Urban Water: The Need for an Integrated Perspective on Institutions, Organizations, and Technology

PubMed Central

Kiparsky, Michael; Sedlak, David L.; Thompson, Barton H.; Truffer, Bernhard

2013-01-01

Abstract Interaction between institutional change and technological change poses important constraints on transitions of urban water systems to a state that can meet future needs. Research on urban water and other technology-dependent systems provides insights that are valuable to technology researchers interested in assuring that their efforts will have an impact. In the context of research on institutional change, innovation is the development, application, diffusion, and utilization of new knowledge and technology. This definition is intentionally inclusive: technological innovation will play a key role in reinvention of urban water systems, but is only part of what is necessary. Innovation usually depends on context, such that major changes to infrastructure include not only the technological inventions that drive greater efficiencies and physical transformations of water treatment and delivery systems, but also the political, cultural, social, and economic factors that hinder and enable such changes. On the basis of past and present changes in urban water systems, institutional innovation will be of similar importance to technological innovation in urban water reinvention. To solve current urban water infrastructure challenges, technology-focused researchers need to recognize the intertwined nature of technologies and institutions and the social systems that control change. PMID:23983450

The emergence and policy implications of converging new technologies integrated from the nanoscale

NASA Astrophysics Data System (ADS)

Roco, M. C.

2005-06-01

Science based on the unified concepts on matter at the nanoscale provides a new foundation for knowledge creation, innovation, and technology integration. Convergent new technologies refers to the synergistic combination of nanotechnology, biotechnology, information technology and cognitive sciences (NBIC), each of which is currently progressing at a rapid rate, experiencing qualitative advancements, and interacting with the more established fields such as mathematics and environmental technologies (Roco & Bainbridge, 2002). It is expected that converging technologies will bring about tremendous improvements in transforming tools, new products and services, enable human personal abilities and social achievements, and reshape societal relationships. After a brief overview of the general implications of converging new technologies, this paper focuses on its effects on R&D policies and business models as part of changing societal relationships. These R&D policies will have implications on investments in research and industry, with the main goal of taking advantage of the transformative development of NBIC. Introduction of converging technologies must be done with respect of immediate concerns (privacy, toxicity of new materials, etc.) and longer-term concerns including human integrity, dignity and welfare. The efficient introduction and development of converging new technologies will require new organizations and business models, as well as solutions for preparing the economy, such as multifunctional research facilities, integrative technology platforms, and global risk governance.

Technology for Climate Change Adaptation in Nepal Himalaya: Policy, Practices and Perspective

NASA Astrophysics Data System (ADS)

Gautam, K.; Panthi, J., Sr.

2016-12-01

The recent scientific findings and the periodic reports corroborated by IPCC has disclosed the climate change is unequivocal and the Himalayan region is one of the hardest hit by the change and variability in climatic system due to its sensitive ecosystem, low resilience capacity and geographical extremes. Nepal, which lies in the central Himalayan region, has developed its strategies to mitigate the impacts of climate change by developing national, regional and local plan of actions which are being implemented and some of them have already been proven. Nepal, as a party to the UNFCCC, has accomplished technology need assessment that identifies the need for new technology, equipment, knowledge and skills for reducing vulnerability to climate change. The plan has recommended an enabling framework for the diffusion of the prioritized technologies and the actions necessary to reduce or remove policy finance and technology related barriers. This paper aims to analyze the technological penetration in national level policy instruments such as NAPA, LAPA, Climate Change Policy and how those technologies have been used in actual field during the implementation of LAPA activities in western Nepal taking two administrative districts, one from low land and another from highland, as a pilot study.

Five key pillars of an analytics center of excellence, which are required to manage populations and transform organizations into the next era of health care.

PubMed

Reichert, Jim; Furlong, Gerry

2014-01-01

Acute care facilities are experiencing fiscal challenges as noted by decreasing admissions and lower reimbursement creating an unsustainable fiscal environment as we move into the next era of health care. This situation necessitates a strategy to move away from acting solely on hunches and instinct to using analytics to become a truly data-driven organization that identifies opportunities within patient populations to improve the quality and efficiency of care across the continuum. A brief overview of knowledge management philosophies will be provided and how it is used to enable organizations to leverage data, information, and knowledge for operational transformation leading to improved outcomes. This article outlines the 5 key pillars of an Analytics Center of Excellence; governance, organizational structure, people, process, and technology, that are foundational to the development of this strategy. While culture is the most important factor to achieve organizational transformation and improved care delivery, it is the 5 pillars of the ACoE that will enable the culture shift necessary to become a truly data-driven organization and thus achieve transformation into the next era of health care.

Enhancing Users' Participation in Business Process Modeling through Ontology-Based Training

NASA Astrophysics Data System (ADS)

Macris, A.; Malamateniou, F.; Vassilacopoulos, G.

Successful business process design requires active participation of users who are familiar with organizational activities and business process modelling concepts. Hence, there is a need to provide users with reusable, flexible, agile and adaptable training material in order to enable them instil their knowledge and expertise in business process design and automation activities. Knowledge reusability is of paramount importance in designing training material on process modelling since it enables users participate actively in process design/redesign activities stimulated by the changing business environment. This paper presents a prototype approach for the design and use of training material that provides significant advantages to both the designer (knowledge - content reusability and semantic web enabling) and the user (semantic search, knowledge navigation and knowledge dissemination). The approach is based on externalizing domain knowledge in the form of ontology-based knowledge networks (i.e. training scenarios serving specific training needs) so that it is made reusable.

Intervention for Diabetes with Education, Advancement and Support (IDEAS) study: protocol for a cluster randomised controlled trial.

PubMed

Lee, Jun Yang; Chan, Carina Ka Yee; Chua, Siew Siang; Ng, Chirk Jenn; Paraidathathu, Thomas; Lee, Kenneth Kwing-Chin; Lee, Shaun Wen Huey

2016-09-29

The high market penetration of mobile phones has triggered an opportunity to combine mobile technology with health care to overcome challenges in today's health care setting. Although Malaysia has a high Internet and mobile penetration rate, evaluations of the efficacy of incorporating this technology in diabetes care is not common. We report the development of a telemonitoring coaching system, using the United Kingdom (UK) Medical Research Council (MRC) framework, for patients with type 2 diabetes mellitus. The Intervention for Diabetes with Education, Technological Advancement and Support (IDEAS) study is a telemonitoring programme based on an empowerment philosophy to enable participants to be responsible for their own health decision and behaviour. An iterative cycle of development, piloting, and collating qualitative and quantitative data will be used to inform and refine the intervention. To increase compliance, the intervention will be designed to encourage self-management using simple, non-technical knowledge. The primary outcomes will be HbA1c, blood pressure, total cholesterol, and quality of life and diabetes self-efficacy. In addition, an economic analysis on health service utilisation will be collected. The mixed-method approach in this study will allow for a holistic overview of using telemonitoring in diabetes care. This design enables researchers to understand the effectiveness of telemonitoring as well as provide insights towards the receptiveness of incorporating information technology amongst type 2 diabetes patients in a community setting. ClinicalTrials.gov NCT02466880 Registered 2 June 2015.

Training mechanical engineering students to utilize biological inspiration during product development.

PubMed

Bruck, Hugh A; Gershon, Alan L; Golden, Ira; Gupta, Satyandra K; Gyger, Lawrence S; Magrab, Edward B; Spranklin, Brent W

2007-12-01

The use of bio-inspiration for the development of new products and devices requires new educational tools for students consisting of appropriate design and manufacturing technologies, as well as curriculum. At the University of Maryland, new educational tools have been developed that introduce bio-inspired product realization to undergraduate mechanical engineering students. These tools include the development of a bio-inspired design repository, a concurrent fabrication and assembly manufacturing technology, a series of undergraduate curriculum modules and a new senior elective in the bio-inspired robotics area. This paper first presents an overview of the two new design and manufacturing technologies that enable students to realize bio-inspired products, and describes how these technologies are integrated into the undergraduate educational experience. Then, the undergraduate curriculum modules are presented, which provide students with the fundamental design and manufacturing principles needed to support bio-inspired product and device development. Finally, an elective bio-inspired robotics project course is present, which provides undergraduates with the opportunity to demonstrate the application of the knowledge acquired through the curriculum modules in their senior year using the new design and manufacturing technologies.

Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?

PubMed

Jones, Peter D; Stelzle, Martin

2016-01-01

Artificial chemical stimulation could provide improvements over electrical neurostimulation. Physiological neurotransmission between neurons relies on the nanoscale release and propagation of specific chemical signals to spatially-localized receptors. Current knowledge of nanoscale fluid dynamics and nanofluidic technology allows us to envision artificial mechanisms to achieve fast, high resolution neurotransmitter release. Substantial technological development is required to reach this goal. Nanofluidic technology-rather than microfluidic-will be necessary; this should come as no surprise given the nanofluidic nature of neurotransmission. This perspective reviews the state of the art of high resolution electrical neuroprostheses and their anticipated limitations. Chemical release rates from nanopores are compared to rates achieved at synapses and with iontophoresis. A review of microfluidic technology justifies the analysis that microfluidic control of chemical release would be insufficient. Novel nanofluidic mechanisms are discussed, and we propose that hydrophobic gating may allow control of chemical release suitable for mimicking neurotransmission. The limited understanding of hydrophobic gating in artificial nanopores and the challenges of fabrication and large-scale integration of nanofluidic components are emphasized. Development of suitable nanofluidic technology will require dedicated, long-term efforts over many years.

An Investigation of the Technological Pedagogical Content Knowledge of Pre-Service Teachers

ERIC Educational Resources Information Center

Horzum, Mehmet Baris

2013-01-01

This study investigates whether pre-service teachers' learning approach and gender are related to their technological knowledge, their technological content knowledge, their technological pedagogical knowledge and their technological pedagogical content knowledge. The sample of the study consisted of 239 pre-service teachers. It was found that an…

A Portal of Educational Resources: Providing Evidence for Matching Pedagogy with Technology

ERIC Educational Resources Information Center

Di Blas, Nicoletta; Fiore, Alessandro; Mainetti, Luca; Vergallo, Roberto; Paolini, Paolo

2014-01-01

The TPACK (Technology, Pedagogy and Content Knowledge) model presents the three types of knowledge that are necessary to implement a successful technology-based educational activity. It highlights how the intersections between TPK (Technological Pedagogical Knowledge), PCK (Pedagogical Content Knowledge) and TCK (Technological Content Knowledge)…

Technological Pedagogical Content Knowledge of Prospective Mathematics Teacher in Three Dimensional Material Based on Sex Differences

NASA Astrophysics Data System (ADS)

Aqib, M. A.; Budiarto, M. T.; Wijayanti, P.

2018-01-01

The effectiveness of learning in this era can be seen from 3 factors such as: technology, content, and pedagogy that covered in Technological Pedagogical Content Knowledge (TPCK). This research was a qualitative research which aimed to describe each domain from TPCK include Content Knowledge, Pedagogical Knowledge, Pedagogical Content Knowledge, Technological Knowledge, Technological Content Knowledge, Technological Pedagogical Knowledge and Technological, Pedagogical, and Content Knowledge. The subjects of this research were male and female mathematics college students at least 5th semester who has almost the same ability for some course like innovative learning, innovative learning II, school mathematics I, school mathematics II, computer applications and instructional media. Research began by spreading the questionnaire of subject then continued with the assignment and interview. The obtained data was validated by time triangulation.This research has result that male and female prospective teacher was relatively same for Content Knowledge and Pedagogical Knowledge domain. While it was difference in the Technological Knowledge domain. The difference in this domain certainly has an impact on other domains that has technology components on it. Although it can be minimized by familiarizing the technology.

The Paralympic athlete: a systematic review of the psychosocial literature.

PubMed

Jefferies, Philip; Gallagher, Pamela; Dunne, Simon

2012-09-01

There is a lack of knowledge of the psychosocial wellbeing and attributes of Paralympic athletes. Such knowledge may reveal what contributes to exceptional performance. To systematically review the literature on psychosocial wellbeing and attributes of the Paralympic athlete. Systematic literature review. Five key databases that index psychosocial literature were searched: CINAHL, ISI Web of Science, MEDLINE, PsycINFO and SportsDiscus. Sixteen papers were found that met the inclusion criteria. The studies were characterised by heterogeneity of design, sample characteristics, outcome assessment and outcomes examined. The emerging thematic areas are 1) participation, motivations and goals; 2) mental imagery; 3) stress and coping; 4) personality; 5) attitudes towards other disabled-bodied athlete groups; 6) knowledge and attitudes towards doping; and 7) transitions to retirement. Relative to the biomechanical aspects of the Paralympian, the psychosocial literature remains limited and diffuse. Nonetheless an understanding of the psychosocial profile of these athletes complements the extant physiological and technological knowledge in enabling a holistic view of what contributes to the successful Paralympic athlete and may facilitate the team working to optimize performance and wellbeing in these high-performing individuals.

Semantic Web, Reusable Learning Objects, Personal Learning Networks in Health: Key Pieces for Digital Health Literacy.

PubMed

Konstantinidis, Stathis Th; Wharrad, Heather; Windle, Richard; Bamidis, Panagiotis D

2017-01-01

The knowledge existing in the World Wide Web is exponentially expanding, while continuous advancements in health sciences contribute to the creation of new knowledge. There are a lot of efforts trying to identify how the social connectivity can endorse patients' empowerment, while other studies look at the identification and the quality of online materials. However, emphasis has not been put on the big picture of connecting the existing resources with the patients "new habits" of learning through their own Personal Learning Networks. In this paper we propose a framework for empowering patients' digital health literacy adjusted to patients' currents needs by utilizing the contemporary way of learning through Personal Learning Networks, existing high quality learning resources and semantics technologies for interconnecting knowledge pieces. The framework based on the concept of knowledge maps for health as defined in this paper. Health Digital Literacy needs definitely further enhancement and the use of the proposed concept might lead to useful tools which enable use of understandable health trusted resources tailored to each person needs.

Towards a Decision Support System for Space Flight Operations

NASA Technical Reports Server (NTRS)

Meshkat, Leila; Hogle, Charles; Ruszkowski, James

2013-01-01

The Mission Operations Directorate (MOD) at the Johnson Space Center (JSC) has put in place a Model Based Systems Engineering (MBSE) technological framework for the development and execution of the Flight Production Process (FPP). This framework has provided much added value and return on investment to date. This paper describes a vision for a model based Decision Support System (DSS) for the development and execution of the FPP and its design and development process. The envisioned system extends the existing MBSE methodology and technological framework which is currently in use. The MBSE technological framework currently in place enables the systematic collection and integration of data required for building an FPP model for a diverse set of missions. This framework includes the technology, people and processes required for rapid development of architectural artifacts. It is used to build a feasible FPP model for the first flight of spacecraft and for recurrent flights throughout the life of the program. This model greatly enhances our ability to effectively engage with a new customer. It provides a preliminary work breakdown structure, data flow information and a master schedule based on its existing knowledge base. These artifacts are then refined and iterated upon with the customer for the development of a robust end-to-end, high-level integrated master schedule and its associated dependencies. The vision is to enhance this framework to enable its application for uncertainty management, decision support and optimization of the design and execution of the FPP by the program. Furthermore, this enhanced framework will enable the agile response and redesign of the FPP based on observed system behavior. The discrepancy of the anticipated system behavior and the observed behavior may be due to the processing of tasks internally, or due to external factors such as changes in program requirements or conditions associated with other organizations that are outside of MOD. The paper provides a roadmap for the three increments of this vision. These increments include (1) hardware and software system components and interfaces with the NASA ground system, (2) uncertainty management and (3) re-planning and automated execution. Each of these increments provide value independently; but some may also enable building of a subsequent increment.

New Algorithm to Enable Construction and Display of 3D Structures from Scanning Probe Microscopy Images Acquired Layer-by-Layer.

PubMed

Deng, William Nanqiao; Wang, Shuo; Ventrici de Souza, Joao; Kuhl, Tonya L; Liu, Gang-Yu

2018-06-25

Scanning probe microscopy (SPM), such as atomic force microscopy (AFM), is widely known for high-resolution imaging of surface structures and nanolithography in two dimensions (2D), providing important physical insights into surface science and material science. This work reports a new algorithm to enable construction and display of layer-by-layer 3D structures from SPM images. The algorithm enables alignment of SPM images acquired during layer-by-layer deposition and removal of redundant features and faithfully constructs the deposited 3D structures. The display uses a "see-through" strategy to enable the structure of each layer to be visible. The results demonstrate high spatial accuracy as well as algorithm versatility; users can set parameters for reconstruction and display as per image quality and research needs. To the best of our knowledge, this method represents the first report to enable SPM technology for 3D imaging construction and display. The detailed algorithm is provided to facilitate usage of the same approach in any SPM software. These new capabilities support wide applications of SPM that require 3D image reconstruction and display, such as 3D nanoprinting and 3D additive and subtractive manufacturing and imaging.

The ecobiopolitics of space biomedicine.

PubMed

Olson, Valerie A

2010-04-01

Using data from an ethnographic study of American astronautics, I argue that, in an inversion of the usual clinical model, astronaut medical subjecthood is fundamentally environmental rather than biological. In extreme environments like outer space, the concept of environment cannot be bracketed out from life processes; as a result, investments of power and knowledge shift from life itself to the sites of interface among living things, technologies, and environments. To illustrate what this means on the ground, I describe space biomedicine as a form of environmental medicine that seeks to optimize and manage technically enabled human ecologies where life and environment are dually problematized. I provide two examples of what I term its ecobiopolitical strategies: creating a new "space normal" physiological category and situating humans as at-risk elements within integrated biological/technological/environmental systems.

Paediatric genomics: diagnosing rare disease in children.

PubMed

Wright, Caroline F; FitzPatrick, David R; Firth, Helen V

2018-05-01

The majority of rare diseases affect children, most of whom have an underlying genetic cause for their condition. However, making a molecular diagnosis with current technologies and knowledge is often still a challenge. Paediatric genomics is an immature but rapidly evolving field that tackles this issue by incorporating next-generation sequencing technologies, especially whole-exome sequencing and whole-genome sequencing, into research and clinical workflows. This complex multidisciplinary approach, coupled with the increasing availability of population genetic variation data, has already resulted in an increased discovery rate of causative genes and in improved diagnosis of rare paediatric disease. Importantly, for affected families, a better understanding of the genetic basis of rare disease translates to more accurate prognosis, management, surveillance and genetic advice; stimulates research into new therapies; and enables provision of better support.

Knowledge management impact of information technology Web 2.0/3.0. The case study of agent software technology usability in knowledge management system

NASA Astrophysics Data System (ADS)

Sołtysik-Piorunkiewicz, Anna

2015-02-01

How we can measure the impact of internet technology Web 2.0/3.0 for knowledge management? How we can use the Web 2.0/3.0 technologies for generating, evaluating, sharing, organizing knowledge in knowledge-based organization? How we can evaluate it from user-centered perspective? Article aims to provide a method for evaluate the usability of web technologies to support knowledge management in knowledge-based organizations of the various stages of the cycle knowledge management, taking into account: generating knowledge, evaluating knowledge, sharing knowledge, etc. for the modern Internet technologies based on the example of agent technologies. The method focuses on five areas of evaluation: GUI, functional structure, the way of content publication, organizational aspect, technological aspect. The method is based on the proposed indicators relating respectively to assess specific areas of evaluation, taking into account the individual characteristics of the scoring. Each of the features identified in the evaluation is judged first point wise, then this score is subject to verification and clarification by means of appropriate indicators of a given feature. The article proposes appropriate indicators to measure the impact of Web 2.0/3.0 technologies for knowledge management and verification them in an example of agent technology usability in knowledge management system.

Knowledge Management in Higher Education Institutions: Enablers and Barriers in Mauritius

ERIC Educational Resources Information Center

Veer Ramjeawon, Poonam; Rowley, Jennifer

2017-01-01

Purpose: The purpose of this study is to contribute to research on knowledge management in higher education institutions (HEIs), by studying the enablers and barriers to knowledge management in a country with a developing higher education sector, Mauritius. Design/methodology/approach: Semi-structured interviews were conducted with senior staff in…

A Working Framework for Enabling International Science Data System Interoperability

NASA Astrophysics Data System (ADS)

Hughes, J. Steven; Hardman, Sean; Crichton, Daniel J.; Martinez, Santa; Law, Emily; Gordon, Mitchell K.

2016-07-01

For diverse scientific disciplines to interoperate they must be able to exchange information based on a shared understanding. To capture this shared understanding, we have developed a knowledge representation framework that leverages ISO level reference models for metadata registries and digital archives. This framework provides multi-level governance, evolves independent of the implementation technologies, and promotes agile development, namely adaptive planning, evolutionary development, early delivery, continuous improvement, and rapid and flexible response to change. The knowledge representation is captured in an ontology through a process of knowledge acquisition. Discipline experts in the role of stewards at the common, discipline, and project levels work to design and populate the ontology model. The result is a formal and consistent knowledge base that provides requirements for data representation, integrity, provenance, context, identification, and relationship. The contents of the knowledge base are translated and written to files in suitable formats to configure system software and services, provide user documentation, validate input, and support data analytics. This presentation will provide an overview of the framework, present a use case that has been adopted by an entire science discipline at the international level, and share some important lessons learned.

Impact of voice- and knowledge-enabled clinical reporting--US example.

PubMed

Bushko, Renata G; Havlicek, Penny L; Deppert, Edward; Epner, Stephen

2002-01-01

This study shows qualitative and quantitative estimates of the national and the clinic level impact of utilizing voice and knowledge enabled clinical reporting systems. Using common sense estimation methodology, we show that the delivery of health care can experience a dramatic improvement in four areas as a result of the broad use of voice and knowledge enabled clinical reporting: (1) Process Quality as measured by cost savings, (2) Organizational Quality as measured by compliance, (3) Clinical Quality as measured by clinical outcomes and (4) Service Quality as measured by patient satisfaction. If only 15 percent of US physicians replaced transcription with modem clinical reporting voice-based methodology, about one half billion dollars could be saved. $6.7 Billion could be saved annually if all medical reporting currently transcribed was handled with voice-and knowledge-enabled dictation and reporting systems.

Panacea, a semantic-enabled drug recommendations discovery framework.

PubMed

Doulaverakis, Charalampos; Nikolaidis, George; Kleontas, Athanasios; Kompatsiaris, Ioannis

2014-03-06

Personalized drug prescription can be benefited from the use of intelligent information management and sharing. International standard classifications and terminologies have been developed in order to provide unique and unambiguous information representation. Such standards can be used as the basis of automated decision support systems for providing drug-drug and drug-disease interaction discovery. Additionally, Semantic Web technologies have been proposed in earlier works, in order to support such systems. The paper presents Panacea, a semantic framework capable of offering drug-drug and drug-diseases interaction discovery. For enabling this kind of service, medical information and terminology had to be translated to ontological terms and be appropriately coupled with medical knowledge of the field. International standard classifications and terminologies, provide the backbone of the common representation of medical data while the medical knowledge of drug interactions is represented by a rule base which makes use of the aforementioned standards. Representation is based on a lightweight ontology. A layered reasoning approach is implemented where at the first layer ontological inference is used in order to discover underlying knowledge, while at the second layer a two-step rule selection strategy is followed resulting in a computationally efficient reasoning approach. Details of the system architecture are presented while also giving an outline of the difficulties that had to be overcome. Panacea is evaluated both in terms of quality of recommendations against real clinical data and performance. The quality recommendation gave useful insights regarding requirements for real world deployment and revealed several parameters that affected the recommendation results. Performance-wise, Panacea is compared to a previous published work by the authors, a service for drug recommendations named GalenOWL, and presents their differences in modeling and approach to the problem, while also pinpointing the advantages of Panacea. Overall, the paper presents a framework for providing an efficient drug recommendations service where Semantic Web technologies are coupled with traditional business rule engines.

Development of a GIService based on spatial data mining for location choice of convenience stores in Taipei City

NASA Astrophysics Data System (ADS)

Jung, Chinte; Sun, Chih-Hong

2006-10-01

Motivated by the increasing accessibility of technology, more and more spatial data are being made digitally available. How to extract the valuable knowledge from these large (spatial) databases is becoming increasingly important to businesses, as well. It is essential to be able to analyze and utilize these large datasets, convert them into useful knowledge, and transmit them through GIS-enabled instruments and the Internet, conveying the key information to business decision-makers effectively and benefiting business entities. In this research, we combine the techniques of GIS, spatial decision support system (SDSS), spatial data mining (SDM), and ArcGIS Server to achieve the following goals: (1) integrate databases from spatial and non-spatial datasets about the locations of businesses in Taipei, Taiwan; (2) use the association rules, one of the SDM methods, to extract the knowledge from the integrated databases; and (3) develop a Web-based SDSS GIService as a location-selection tool for business by the product of ArcGIS Server.

Technologies that enable congestion pricing : a primer

DOT National Transportation Integrated Search

2008-10-01

This volume explores transportation technologies that enable congestion pricing. This document considers the following: the functional processes for tolling and congestion pricing; what technologies there are to consider; how the technologies are app...

m-Health Policy Readiness and Enabling Factors: Comparisons of Sub-Saharan Africa and Organization for Economic Cooperation and Development Countries.

PubMed

Lee, Seohyun; Begley, Charles E; Morgan, Robert; Chan, Wenyaw; Kim, Sun-Young

2018-02-12

As an innovative solution to poor access to care in low- and middle-income countries (LMICs), m-health has gained wide attention in the past decade. Despite enthusiasm from the global health community, LMICs have not demonstrated high uptake of m-health promoting policies or public investment. To benchmark the current status, this study compared m-health policy readiness scores between sub-Saharan Africa and high-income Organization for Economic Cooperation and Development (OECD) countries using an independent two-sample t test. In addition, the enabling factors associated with m-health policy readiness were investigated using an ordinal logistic regression model. The study was based on the m-health policy readiness scores of 112 countries obtained from the World Health Organization Third Global Survey on e-Health. The mean m-health policy readiness score for sub-Saharan Africa was statistically significantly lower than that for OECD countries (p = 0.02). The enabling factors significantly associated with m-health policy readiness included information and communication technology development index (odds ratio [OR] 1.57; 95% confidence interval [CI] 1.12-2.2), e-health education for health professionals (OR 4.43; 95% CI 1.60-12.27), and the location in sub-Saharan Africa (OR 3.47; 95% CI 1.06-11.34). The findings of our study suggest dual policy goals for m-health in sub-Saharan Africa. First, enhance technological and educational support for m-health. Second, pursue global collaboration for building m-health capacity led by sub-Saharan African countries with hands-on experience and knowledge. Globally, countries should take a systematic and collaborative approach in pursuing m-health policy with the focus on technological and educational support.

WikiHyperGlossary (WHG): an information literacy technology for chemistry documents.

PubMed

Bauer, Michael A; Berleant, Daniel; Cornell, Andrew P; Belford, Robert E

2015-01-01

The WikiHyperGlossary is an information literacy technology that was created to enhance reading comprehension of documents by connecting them to socially generated multimedia definitions as well as semantically relevant data. The WikiHyperGlossary enhances reading comprehension by using the lexicon of a discipline to generate dynamic links in a document to external resources that can provide implicit information the document did not explicitly provide. Currently, the most common method to acquire additional information when reading a document is to access a search engine and browse the web. This may lead to skimming of multiple documents with the novice actually never returning to the original document of interest. The WikiHyperGlossary automatically brings information to the user within the current document they are reading, enhancing the potential for deeper document understanding. The WikiHyperGlossary allows users to submit a web URL or text to be processed against a chosen lexicon, returning the document with tagged terms. The selection of a tagged term results in the appearance of the WikiHyperGlossary Portlet containing a definition, and depending on the type of word, tabs to additional information and resources. Current types of content include multimedia enhanced definitions, ChemSpider query results, 3D molecular structures, and 2D editable structures connected to ChemSpider queries. Existing glossaries can be bulk uploaded, locked for editing and associated with multiple social generated definitions. The WikiHyperGlossary leverages both social and semantic web technologies to bring relevant information to a document. This can not only aid reading comprehension, but increases the users' ability to obtain additional information within the document. We have demonstrated a molecular editor enabled knowledge framework that can result in a semantic web inductive reasoning process, and integration of the WikiHyperGlossary into other software technologies, like the Jikitou Biomedical Question and Answer system. Although this work was developed in the chemical sciences and took advantage of open science resources and initiatives, the technology is extensible to other knowledge domains. Through the DeepLit (Deeper Literacy: Connecting Documents to Data and Discourse) startup, we seek to extend WikiHyperGlossary technologies to other knowledge domains, and integrate them into other knowledge acquisition workflows.

Sparse Regression Based Structure Learning of Stochastic Reaction Networks from Single Cell Snapshot Time Series.

PubMed

Klimovskaia, Anna; Ganscha, Stefan; Claassen, Manfred

2016-12-01

Stochastic chemical reaction networks constitute a model class to quantitatively describe dynamics and cell-to-cell variability in biological systems. The topology of these networks typically is only partially characterized due to experimental limitations. Current approaches for refining network topology are based on the explicit enumeration of alternative topologies and are therefore restricted to small problem instances with almost complete knowledge. We propose the reactionet lasso, a computational procedure that derives a stepwise sparse regression approach on the basis of the Chemical Master Equation, enabling large-scale structure learning for reaction networks by implicitly accounting for billions of topology variants. We have assessed the structure learning capabilities of the reactionet lasso on synthetic data for the complete TRAIL induced apoptosis signaling cascade comprising 70 reactions. We find that the reactionet lasso is able to efficiently recover the structure of these reaction systems, ab initio, with high sensitivity and specificity. With only < 1% false discoveries, the reactionet lasso is able to recover 45% of all true reactions ab initio among > 6000 possible reactions and over 102000 network topologies. In conjunction with information rich single cell technologies such as single cell RNA sequencing or mass cytometry, the reactionet lasso will enable large-scale structure learning, particularly in areas with partial network structure knowledge, such as cancer biology, and thereby enable the detection of pathological alterations of reaction networks. We provide software to allow for wide applicability of the reactionet lasso.

A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

DOE PAGES

Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.; ...

2013-01-01

Background . The availability of large complex data sets generated by high throughput technologies has enabled the recent proliferation of disease biomarker studies. However, a recurring problem in deriving biological information from large data sets is how to best incorporate expert knowledge into the biomarker selection process. Objective . To develop a generalizable framework that can incorporate expert knowledge into data-driven processes in a semiautomated way while providing a metric for optimization in a biomarker selection scheme. Methods . The framework was implemented as a pipeline consisting of five components for the identification of signatures from integrated clustering (ISIC). Expertmore » knowledge was integrated into the biomarker identification process using the combination of two distinct approaches; a distance-based clustering approach and an expert knowledge-driven functional selection. Results . The utility of the developed framework ISIC was demonstrated on proteomics data from a study of chronic obstructive pulmonary disease (COPD). Biomarker candidates were identified in a mouse model using ISIC and validated in a study of a human cohort. Conclusions . Expert knowledge can be introduced into a biomarker discovery process in different ways to enhance the robustness of selected marker candidates. Developing strategies for extracting orthogonal and robust features from large data sets increases the chances of success in biomarker identification.« less

An investigation into whether nursing student alter their attitudes and knowledge levels regarding HIV infection and AIDS following a 3-year programme leading to registration as a qualified nurse.

PubMed

Snowden, L

1997-06-01

The purpose of this study was to examine whether a 3-year programme of nursing studies enabled nursing students to graduate from the course with greater knowledge and more positive attitudes towards HIV infection and AIDS than when they began the course. Students on a maths and information technology course were used as controls. The study involved the use of a questionnaire which gathered information about students' experience, knowledge, attitudes and moral judgement regarding HIV infection and AIDS. The experimental hypothesis stated that nursing students would show a greater increase in knowledge and positive attitude change towards HIV infection and AIDS than maths students. The results showed significant differences between third year nursing students' knowledge about HIV and AIDS when compared with other groups but it was noted that knowledge levels for all groups was quite low. There was no difference between first and third year nursing students' attitudes and moral judgement about HIV and AIDS but there was a significant difference between nursing students and maths students. It was suggested that there is a need to modify nurse education programmes in order to have greater impact on this topic area.

A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

PubMed Central

Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.; Varnum, Susan M.; Brown, Joseph N.; Riensche, Roderick M.; Adkins, Joshua N.; Jacobs, Jon M.; Hoidal, John R.; Scholand, Mary Beth; Pounds, Joel G.; Blackburn, Michael R.; Rodland, Karin D.; McDermott, Jason E.

2013-01-01

Background. The availability of large complex data sets generated by high throughput technologies has enabled the recent proliferation of disease biomarker studies. However, a recurring problem in deriving biological information from large data sets is how to best incorporate expert knowledge into the biomarker selection process. Objective. To develop a generalizable framework that can incorporate expert knowledge into data-driven processes in a semiautomated way while providing a metric for optimization in a biomarker selection scheme. Methods. The framework was implemented as a pipeline consisting of five components for the identification of signatures from integrated clustering (ISIC). Expert knowledge was integrated into the biomarker identification process using the combination of two distinct approaches; a distance-based clustering approach and an expert knowledge-driven functional selection. Results. The utility of the developed framework ISIC was demonstrated on proteomics data from a study of chronic obstructive pulmonary disease (COPD). Biomarker candidates were identified in a mouse model using ISIC and validated in a study of a human cohort. Conclusions. Expert knowledge can be introduced into a biomarker discovery process in different ways to enhance the robustness of selected marker candidates. Developing strategies for extracting orthogonal and robust features from large data sets increases the chances of success in biomarker identification. PMID:24223463

An Ebola virus-centered knowledge base

PubMed Central

Kamdar, Maulik R.; Dumontier, Michel

2015-01-01

Ebola virus (EBOV), of the family Filoviridae viruses, is a NIAID category A, lethal human pathogen. It is responsible for causing Ebola virus disease (EVD) that is a severe hemorrhagic fever and has a cumulative death rate of 41% in the ongoing epidemic in West Africa. There is an ever-increasing need to consolidate and make available all the knowledge that we possess on EBOV, even if it is conflicting or incomplete. This would enable biomedical researchers to understand the molecular mechanisms underlying this disease and help develop tools for efficient diagnosis and effective treatment. In this article, we present our approach for the development of an Ebola virus-centered Knowledge Base (Ebola-KB) using Linked Data and Semantic Web Technologies. We retrieve and aggregate knowledge from several open data sources, web services and biomedical ontologies. This knowledge is transformed to RDF, linked to the Bio2RDF datasets and made available through a SPARQL 1.1 Endpoint. Ebola-KB can also be explored using an interactive Dashboard visualizing the different perspectives of this integrated knowledge. We showcase how different competency questions, asked by domain users researching the druggability of EBOV, can be formulated as SPARQL Queries or answered using the Ebola-KB Dashboard. Database URL: http://ebola.semanticscience.org. PMID:26055098

An Ebola virus-centered knowledge base.

PubMed

Kamdar, Maulik R; Dumontier, Michel

2015-01-01

Ebola virus (EBOV), of the family Filoviridae viruses, is a NIAID category A, lethal human pathogen. It is responsible for causing Ebola virus disease (EVD) that is a severe hemorrhagic fever and has a cumulative death rate of 41% in the ongoing epidemic in West Africa. There is an ever-increasing need to consolidate and make available all the knowledge that we possess on EBOV, even if it is conflicting or incomplete. This would enable biomedical researchers to understand the molecular mechanisms underlying this disease and help develop tools for efficient diagnosis and effective treatment. In this article, we present our approach for the development of an Ebola virus-centered Knowledge Base (Ebola-KB) using Linked Data and Semantic Web Technologies. We retrieve and aggregate knowledge from several open data sources, web services and biomedical ontologies. This knowledge is transformed to RDF, linked to the Bio2RDF datasets and made available through a SPARQL 1.1 Endpoint. Ebola-KB can also be explored using an interactive Dashboard visualizing the different perspectives of this integrated knowledge. We showcase how different competency questions, asked by domain users researching the druggability of EBOV, can be formulated as SPARQL Queries or answered using the Ebola-KB Dashboard. © The Author(s) 2015. Published by Oxford University Press.

A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.

2013-10-01

Background. The availability of large complex data sets generated by high throughput technologies has enabled the recent proliferation of disease biomarker studies. However, a recurring problem in deriving biological information from large data sets is how to best incorporate expert knowledge into the biomarker selection process. Objective. To develop a generalizable framework that can incorporate expert knowledge into data-driven processes in a semiautomated way while providing a metric for optimization in a biomarker selection scheme. Methods. The framework was implemented as a pipeline consisting of five components for the identification of signatures from integrated clustering (ISIC). Expert knowledge was integratedmore » into the biomarker identification process using the combination of two distinct approaches; a distance-based clustering approach and an expert knowledge-driven functional selection. Results. The utility of the developed framework ISIC was demonstrated on proteomics data from a study of chronic obstructive pulmonary disease (COPD). Biomarker candidates were identified in a mouse model using ISIC and validated in a study of a human cohort. Conclusions. Expert knowledge can be introduced into a biomarker discovery process in different ways to enhance the robustness of selected marker candidates. Developing strategies for extracting orthogonal and robust features from large data sets increases the chances of success in biomarker identification.« less

Knowledge and use of information and communication technology by health sciences students of the University of Ghana.

PubMed

Dery, Samuel; Vroom, Frances da-Costa; Godi, Anthony; Afagbedzi, Seth; Dwomoh, Duah

2016-09-01

Studies have shown that ICT adoption contributes to productivity and economic growth. It is therefore important that health workers have knowledge in ICT to ensure adoption and uptake of ICT tools to enable efficient health delivery. To determine the knowledge and use of ICT among students of the College of Health Sciences at the University of Ghana. This was a cross-sectional study conducted among students in all the five Schools of the College of Health Sciences at the University of Ghana. A total of 773 students were sampled from the Schools. Sampling proportionate to size was then used to determine the sample sizes required for each school, academic programme and level of programme. Simple random sampling was subsequently used to select students from each stratum. Computer knowledge was high among students at almost 99%. About 83% owned computers (p < 0.001) and self-rated computer knowledge was also 87 % (p <0.001). Usage was mostly for studying at 93% (p< 0.001). This study shows students have adequate knowledge and use of computers. It brings about an opportunity to introduce ICT in healthcare delivery to them. This will ensure their adequate preparedness to embrace new ways of delivering care to improve service delivery. Africa Build Project, Grant Number: FP7-266474.

Knitting for heart valve tissue engineering

PubMed Central

Ayad, Nadia; Wojciechowska, Dorota; Zielińska, Dorota; Struszczyk, Marcin H.; Latif, Najma; Yacoub, Magdi

Knitting is a versatile technology which offers a large portfolio of products and solutions of interest in heart valve (HV) tissue engineering (TE). One of the main advantages of knitting is its ability to construct complex shapes and structures by precisely assembling the yarns in the desired position. With this in mind, knitting could be employed to construct a HV scaffold that closely resembles the authentic valve. This has the potential to reproduce the anisotropic structure that is characteristic of the heart valve with the yarns, in particular the 3-layered architecture of the leaflets. These yarns can provide oriented growth of cells lengthwise and consequently enable the deposition of extracellular matrix (ECM) proteins in an oriented manner. This technique, therefore, has a potential to provide a functional knitted scaffold, but to achieve that textile engineers need to gain a basic understanding of structural and mechanical aspects of the heart valve and in addition, tissue engineers must acquire the knowledge of tools and capacities that are essential in knitting technology. The aim of this review is to provide a platform to consolidate these two fields as well as to enable an efficient communication and cooperation among these two research areas. PMID:29043276

Digital patient: Personalized and translational data management through the MyHealthAvatar EU project.

PubMed

Kondylakis, Haridimos; Spanakis, Emmanouil G; Sfakianakis, Stelios; Sakkalis, Vangelis; Tsiknakis, Manolis; Marias, Kostas; Xia Zhao; Hong Qing Yu; Feng Dong

2015-08-01

The advancements in healthcare practice have brought to the fore the need for flexible access to health-related information and created an ever-growing demand for the design and the development of data management infrastructures for translational and personalized medicine. In this paper, we present the data management solution implemented for the MyHealthAvatar EU research project, a project that attempts to create a digital representation of a patient's health status. The platform is capable of aggregating several knowledge sources relevant for the provision of individualized personal services. To this end, state of the art technologies are exploited, such as ontologies to model all available information, semantic integration to enable data and query translation and a variety of linking services to allow connecting to external sources. All original information is stored in a NoSQL database for reasons of efficiency and fault tolerance. Then it is semantically uplifted through a semantic warehouse which enables efficient access to it. All different technologies are combined to create a novel web-based platform allowing seamless user interaction through APIs that support personalized, granular and secure access to the relevant information.

What Is Technological Pedagogical Content Knowledge (TPACK)?

ERIC Educational Resources Information Center

Koehler, Mathew J.; Mishra, Punya; Cain, William

2013-01-01

This paper describes TPACK, technological pedagogical content knowledge (originally TPCK), a teacher knowledge framework for technology integration that builds on Lee S. Shulman's construct of pedagogical content knowledge to include technology knowledge. The paper begins with a brief introduction to the complex, ill-structured nature of teaching.…

Complexity and conundrums. Citizens' evaluations of potentially contentious novel food technologies using a deliberative discourse approach.

PubMed

Greehy, Gráinne M; McCarthy, Mary B; Henchion, Maeve M; Dillon, Emma J; McCarthy, Sinéad N

2013-11-01

This research considers the processes involved in the formation of attitudes by citizens on potentially contentious novel food technologies (NFTs). Observations of one-to-one deliberative discourses between food scientists and citizens, during which they discussed these technologies, form the basis of this enquiry. This approach enables an exploration of how individuals construct meaning around as well as interpret information about the technologies. Thematic analysis identifies key features that provide the frameworks for citizens' evaluations. How individuals make sense of these technologies is shaped by their beliefs, values and personal characteristics; their perceptions of power and control over the development and sale of NFT related products; and, the extent to which these products are relevant to their personal lives. Internal negotiations between these influences are evident, and evaluations are based on the relative importance of each influence to the individual. Internal conflicts and tensions are associated with citizens' evolving evaluative processes, which may in turn present as attitude ambivalence and instability. Many challenges are linked with engaging with the general public about these technologies, as levels of knowledge, understanding and interest vary. Copyright © 2013 Elsevier Ltd. All rights reserved.

Enabling Communication and Navigation Technologies for Future Near Earth Science Missions

NASA Technical Reports Server (NTRS)

Israel, David J.; Heckler, Greg; Menrad, Robert J.; Hudiburg, John J.; Boroson, Don M.; Robinson, Bryan S.; Cornwell, Donald M.

2016-01-01

In 2015, the Earth Regimes Network Evolution Study (ERNESt) Team proposed a fundamentally new architectural concept, with enabling technologies, that defines an evolutionary pathway out to the 2040 timeframe in which an increasing user community comprised of more diverse space science and exploration missions can be supported. The architectural concept evolves the current instantiations of the Near Earth Network and Space Network through implementation of select technologies resulting in a global communication and navigation network that provides communication and navigation services to a wide range of space users in the Near Earth regime, defined as an Earth-centered sphere with radius of 2M Km. The enabling technologies include: High Rate Optical Communications, Optical Multiple Access (OMA), Delay Tolerant Networking (DTN), User Initiated Services (UIS), and advanced Position, Navigation, and Timing technology (PNT). This paper describes this new architecture, the key technologies that enable it and their current technology readiness levels. Examples of science missions that could be enabled by the technologies and the projected operational benefits of the architecture concept to missions are also described.

Web-enabling technologies for the factory floor: a web-enabling strategy for emanufacturing

NASA Astrophysics Data System (ADS)

Velez, Ricardo; Lastra, Jose L. M.; Tuokko, Reijo O.

2001-10-01

This paper is intended to address the different technologies available for Web-enabling of the factory floor. It will give an overview of the importance of Web-enabling of the factory floor, in the application of the concepts of flexible and intelligent manufacturing, in conjunction with e-commerce. As a last section, it will try to define a Web-enabling strategy for the application in eManufacturing. This is made under the scope of the electronics manufacturing industry, so every application, technology or related matter is presented under such scope.

Youth Participatory Action Research (YPAR) 2.0: how technological innovation and digital organizing sparked a food revolution in East Oakland.

PubMed

Akom, Antwi; Shah, Aekta; Nakai, Aaron; Cruz, Tessa

2016-01-01

This article argues that technological innovation is transforming the flow of information, the fluidity of social action, and is giving birth to new forms of bottom up innovation that are capable of expanding and exploding old theories of reproduction and resistance because 'smart mobs', 'street knowledge', and 'social movements' cannot be neutralized by powerful structural forces in the same old ways. The purpose of this article is to develop the concept of YPAR 2.0 in which new technologies enable young people to visualize, validate, and transform social inequalities by using local knowledge in innovative ways that deepen civic engagement, democratize data, expand educational opportunity, inform policy, and mobilize community assets. Specifically this article documents how digital technology (including a mobile, mapping and SMS platform called Streetwyze and paper-mapping tool Local Ground) - coupled with 'ground-truthing' - an approach in which community members work with researchers to collect and verify 'public' data - sparked a food revolution in East Oakland that led to an increase in young people's self-esteem, environmental stewardship, academic engagement, and positioned urban youth to become community leaders and community builders who are connected and committed to health and well-being of their neighborhoods. This article provides an overview of how the YPAR 2.0 Model was developed along with recommendations and implications for future research and collaborations between youth, teachers, neighborhood leaders, and youth serving organizations.

Measuring Cognition of Students with Disabilities Using Technology-Enabled Assessments: Recommendations for a National Research Agenda

ERIC Educational Resources Information Center

Bechard, Sue; Sheinker, Jan; Abell, Rosemary; Barton, Karen; Burling, Kelly; Camacho, Christopher; Cameto, Renee; Haertel, Geneva; Hansen, Eric; Johnstone, Chris; Kingston, Neal; Murray, Elizabeth; Parker, Caroline E.; Redfield, Doris; Tucker, Bill

2010-01-01

This article represents one outcome from the "Invitational Research Symposium on Technology-Enabled and Universally Designed Assessments," which examined technology-enabled assessments (TEA) and universal design (UD) as they relate to students with disabilities (SWD). It was developed to stimulate research into TEAs designed to better understand…

Emerging technologies and web accessibility: research challenges and opportunities focussing on vision issues.

PubMed

Harper, Simon; Yesilada, Yeliz

2012-01-01

This is a technological review paper focussed on identifying both the research challenges and opportunities for further investigation arising from emerging technologies, and it does not aim to propose any recommendation or standard. It is focussed on blind and partially sighted World Wide Web (Web) users along with others who use assistive technologies. The Web is a fast moving interdisciplinary domain in which new technologies, techniques and research is in perpetual development. It is often difficult to maintain a holistic view of new developments within the multiple domains which together make up the Web. This suggests that knowledge of the current developments and predictions of future developments are additionally important for the accessibility community. Web accessibility has previously been characterised by the correction of our past mistakes to make the current Web fulfil the original vision of access for all. New technologies were not designed with accessibility in mind and technologies that could be useful for addressing accessibility issues were not identified or adopted by the accessibility community. We wish to enable the research community to undertake preventative measures and proactively address challenges, while recognising opportunities, before they become unpreventable or require retrospective technological enhancement. This article then reviews emerging trends within the Web and Web Accessibility domains.

A Way to Select Electrical Sheets of the Segment Stator Core Motors.

NASA Astrophysics Data System (ADS)

Enomoto, Yuji; Kitamura, Masashi; Sakai, Toshihiko; Ohara, Kouichiro

The segment stator core, high density winding coil, high-energy-product permanent magnet are indispensable technologies in the development of a compact and also high efficient motors. The conventional design method for the segment stator core mostly depended on experienced knowledge of selecting a suitable electromagnetic material, far from optimized design. Therefore, we have developed a novel design method in the selection of a suitable electromagnetic material based on the correlation evaluation between the material characteristics and motor performance. It enables the selection of suitable electromagnetic material that will meet the motor specification.

Support for comprehensive reuse

NASA Technical Reports Server (NTRS)

Basili, V. R.; Rombach, H. D.

1991-01-01

Reuse of products, processes, and other knowledge will be the key to enable the software industry to achieve the dramatic improvement in productivity and quality required to satisfy the anticipated growing demands. Although experience shows that certain kinds of reuse can be successful, general success has been elusive. A software life-cycle technology which allows comprehensive reuse of all kinds of software-related experience could provide the means to achieving the desired order-of-magnitude improvements. A comprehensive framework of models, model-based characterization schemes, and support mechanisms for better understanding, evaluating, planning, and supporting all aspects of reuse are introduced.

New NASA Laser Technology Reveals How Ice Measures Up

NASA Image and Video Library

2014-01-28

NASA's Multiple Altimeter Beam Experimental Lidar flew over Southwest Greenland's glaciers and sea ice to test a new method of measuring the height of Earth from space. Read more here: 1.usa.gov/1fkvoBp Credit: NASA/Tim Williams NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Single-Cell Genomics Unravels Brain Cell-Type Complexity.

PubMed

Guillaumet-Adkins, Amy; Heyn, Holger

2017-01-01

The brain is the most complex tissue in terms of cell types that it comprises, to the extent that it is still poorly understood. Single cell genome and transcriptome profiling allow to disentangle the neuronal heterogeneity, enabling the categorization of individual neurons into groups with similar molecular signatures. Herein, we unravel the current state of knowledge in single cell neurogenomics. We describe the molecular understanding of the cellular architecture of the mammalian nervous system in health and in disease; from the discovery of unrecognized cell types to the validation of known ones, applying these state-of-the-art technologies.

A brief history and technical review of the expert system research

NASA Astrophysics Data System (ADS)

Tan, Haocheng

2017-09-01

The expert system is a computer system that emulates the decision-making ability of a human expert, which aims to solve complex problems by reasoning knowledge. It is an important branch of artificial intelligence. In this paper, firstly, we briefly introduce the development and basic structure of the expert system. Then, from the perspective of the enabling technology, we classify the current expert systems and elaborate four expert systems: The Rule-Based Expert System, the Framework-Based Expert System, the Fuzzy Logic-Based Expert System and the Expert System Based on Neural Network.

Author Steven Johnson, How We Got to Now, Innovative Initiatives workshop, Innovative Technology Partnerships Office (IPTO)

NASA Image and Video Library

2014-11-13

NASA's Goddard Space Flight Center welcomed Steven Johnson, author of How We Got to Now: Six Innovations That Made the Modern World, to the Innovative Initiatives workshop on Thursday, November 13, 2014 Credit: NASA/Goddard/Bill Hrybyk NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Management of Knowledge Representation Standards Activities

NASA Technical Reports Server (NTRS)

Patil, Ramesh S. (Principal Investigator)

1993-01-01

This report describes the efforts undertaken over the last two years to identify the issues underlying the current difficulties in sharing and reuse, and a community wide initiative to overcome them. First, we discuss four bottlenecks to sharing and reuse, present a vision of a future in which these bottlenecks have been ameliorated, and describe the efforts of the initiative's four working groups to address these bottlenecks. We then address the supporting technology and infrastructure that is critical to enabling the vision of the future. Finally, we consider topics of longer-range interest by reviewing some of the research issues raised by our vision.

Using JWST Heritage to Enable a Future Large Ultra-Violet Optical Infrared Telescope

NASA Technical Reports Server (NTRS)

Feinberg, Lee

2016-01-01

To the extent it makes sense, leverage JWST knowledge, designs, architectures, GSE. Develop a scalable design reference mission (9.2 meter). Do just enough work to understand launch break points in aperture size. Demonstrate 10 pm stability is achievable on a design reference mission. Make design compatible with starshades. While segmented coronagraphs with high throughput and large bandpasses are important, make the system serviceable so you can evolve the instruments. Keep it room temperature to minimize the costs associated with cryo. Focus resources on the contrast problem. Start with the architecture and connect it to the technology needs.

Fabrics Protect Sensitive Skin from UV Rays

NASA Technical Reports Server (NTRS)

2009-01-01

Late Johnson Space Center engineer Dr. Robert Dotts headed a team to develop cool suits for children suffering from life-threatening sun sensitivities. Dotts hoped to develop ultraviolet-blocking technology in a fabric that -- unlike in a bulky space suit -- could remain comfortable, light, and breathable in the sun and heat. The team worked with SPF 4 US LLC (SPF) of Madison, Wisconsin to design ultraviolet-blocking cool suits, which protect sun-sensitive patients and enable them to experience life outdoors safely. Using knowledge gained during the NASA collaboration, SPF created an entire line of ultraviolet-blocking apparel.

[MEDICAL SOCIAL MODELING TECHNOLOGIES FOR ACTIVE AGING IN KAZAKHSTAN].

PubMed

Benberin, V V; Akhetov, A A; Tanbaeva, G Z

2015-01-01

The article discusses a new model for active ageing in Republic of Kazakhstan with participation the state, population and medical social services. Achieving active longevity will lead to positive trends in the development of human capital of the state, because it enables to use experience and knowledge of senior generation in enhancing the effectiveness of socio-economic transformation in health care. The study was carried out on the base of the Central clinical hospital of the President's affairs administration in Republic of Kazakhstan, with the participation of 147 admitted patients of elderly and senile age.

Author Steven Johnson, How We Got to Now, Innovative Initiatives workshop, Innovative Technology Partnerships Office (IPTO)

NASA Image and Video Library

2017-12-08

NASA's Goddard Space Flight Center welcomed Steven Johnson, author of How We Got to Now: Six Innovations That Made the Modern World, to the Innovative Initiatives workshop on Thursday, November 13, 2014 Credit: NASA/Goddard/Bill Hrybyk NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Calling on a million minds for community annotation in WikiProteins

PubMed Central

Mons, Barend; Ashburner, Michael; Chichester, Christine; van Mulligen, Erik; Weeber, Marc; den Dunnen, Johan; van Ommen, Gert-Jan; Musen, Mark; Cockerill, Matthew; Hermjakob, Henning; Mons, Albert; Packer, Abel; Pacheco, Roberto; Lewis, Suzanna; Berkeley, Alfred; Melton, William; Barris, Nickolas; Wales, Jimmy; Meijssen, Gerard; Moeller, Erik; Roes, Peter Jan; Borner, Katy; Bairoch, Amos

2008-01-01

WikiProteins enables community annotation in a Wiki-based system. Extracts of major data sources have been fused into an editable environment that links out to the original sources. Data from community edits create automatic copies of the original data. Semantic technology captures concepts co-occurring in one sentence and thus potential factual statements. In addition, indirect associations between concepts have been calculated. We call on a 'million minds' to annotate a 'million concepts' and to collect facts from the literature with the reward of collaborative knowledge discovery. The system is available for beta testing at . PMID:18507872

Remote control of the industry processes. POWERLINK protocol application

NASA Astrophysics Data System (ADS)

Wóbel, A.; Paruzel, D.; Paszkiewicz, B.

2017-08-01

The present technological development enables the use of solutions characterized by a lower failure rate, and work with greater precision. This allows you to obtain the most efficient production, high speed production and reliability of individual components. The main scope of this article was POWERLINK protocol application for communication with the controller B & R through communication Ethernet for recording process parameters. This enables control of run production cycle using an internal network connected to the PC industry. Knowledge of the most important parameters of the production in real time allows detecting of a failure immediately after occurrence. For this purpose, the position of diagnostic use driver X20CP1301 B&R to record measurement data such as pressure, temperature valve between the parties and the torque required to change the valve setting was made. The use of POWERLINK protocol allows for the transmission of information on the status of every 200 μs.

Policy perspectives on the emerging pathways of personalized medicine

PubMed Central

Downing, Gregory J.

2009-01-01

Remarkable advances in the fundamental knowledge about the biological basis of disease and technical advances in methods to assess genomic information have led the health care system to the threshold of personalized medicine. It is now feasible to consider strategic application of genomic information to guide patient management by being predictive, preemptive, and preventive, and enabling patient participation in medical decisions. Early evidence of this transition has some hallmarks of disruptive innovation to existing health care practices. Presented here is an examination of the changes underway to enable this new concept in health care in the United States, to improve precision and quality of care through innovations aimed at individualized approaches to medical decision making. A broad range of public policy positions will need to be considered for the health care delivery enterprise to accommodate the promise of this new science and technology for the benefit of patients. PMID:20135895

Telemedicine in diabetes foot care delivery: health care professionals' experience.

PubMed

Kolltveit, Beate-Christin Hope; Gjengedal, Eva; Graue, Marit; Iversen, Marjolein M; Thorne, Sally; Kirkevold, Marit

2016-04-18

Introducing new technology in health care is inevitably a challenge. More knowledge is needed to better plan future telemedicine interventions. Our aim was therefore to explore health care professionals' experience in the initial phase of introducing telemedicine technology in caring for people with diabetic foot ulcers. Our methodological strategy was Interpretive Description. Data were collected between 2014 and 2015 using focus groups (n = 10). Participants from home-based care, primary care and outpatient hospital clinics were recruited from the intervention arm of an ongoing cluster randomized controlled trial (RCT) (Clinicaltrials.gov: NCT01710774). Most were nurses (n = 29), but the sample also included one nurse assistant, podiatrists (n = 2) and physicians (n = 2). The participants reported experiencing meaningful changes to their practice arising from telemedicine, especially associated with increased wound assessment knowledge and skills and improved documentation quality. They also experienced more streamlined communication between primary health care and specialist health care. Despite obstacles associated with finding the documentation process time consuming, the participants' attitudes to telemedicine were overwhelmingly positive and their general enthusiasm for the innovation was high. Our findings indicate that using a telemedicine intervention enabled the participating health care professionals to approach their patients with diabetic foot ulcer with more knowledge, better wound assessment skills and heightened confidence. Furthermore, it streamlined the communication between health care levels and helped seeing the patients in a more holistic way.

Cassava: constraints to production and the transfer of biotechnology to African laboratories.

PubMed

Bull, Simon E; Ndunguru, Joseph; Gruissem, Wilhelm; Beeching, John R; Vanderschuren, Hervé

2011-05-01

Knowledge and technology transfer to African institutes is an important objective to help achieve the United Nations Millennium Development Goals. Plant biotechnology in particular enables innovative advances in agriculture and industry, offering new prospects to promote the integration and dissemination of improved crops and their derivatives from developing countries into local markets and the global economy. There is also the need to broaden our knowledge and understanding of cassava as a staple food crop. Cassava (Manihot esculenta Crantz) is a vital source of calories for approximately 500 million people living in developing countries. Unfortunately, it is subject to numerous biotic and abiotic stresses that impact on production, consumption, marketability and also local and country economics. To date, improvements to cassava have been led via conventional plant breeding programmes, but with advances in molecular-assisted breeding and plant biotechnology new tools are being developed to hasten the generation of improved farmer-preferred cultivars. In this review, we report on the current constraints to cassava production and knowledge acquisition in Africa, including a case study discussing the opportunities and challenges of a technology transfer programme established between the Mikocheni Agricultural Research Institute in Tanzania and Europe-based researchers. The establishment of cassava biotechnology platform(s) should promote research capabilities in African institutions and allow scientists autonomy to adapt cassava to suit local agro-ecosystems, ultimately serving to develop a sustainable biotechnology infrastructure in African countries.

The rise of information science: a changing landscape for soil science

NASA Astrophysics Data System (ADS)

Roudier, Pierre; Ritchie, Alistair; Hedley, Carolyn; Medyckyj-Scott, David

2015-07-01

The last 15 years have seen the rapid development of a wide range of information technologies. Those developments have been impacting all fields of science, at every step of the scientific method: data collection, data analysis, inference, science communication and outreach. The rate at which data is being generated is increasing exponentially, giving opportunities to improve our understanding of soils. Parallel developments in computing hardware and methods, such as machine learning, open ways to not only harness the '”data deluge”, but also offer a new way to generate knowledge. Finally, emerging data and information delivery protocols are leveraging the outreach power of the World Wide Web to disseminate scientific data and information, and increase their use and understanding outside the boundaries of a given scientific field. However, the nature of this data is mostly new to soil science, and requires adaptation to its diversity and volume. In particular, the integration of the significant amount of legacy soil data collected throughout decades of soil science can be problematic when all necessary metadata is not available. Likewise, knowledge accumulated by our scientific field needs to be acknowledged by - rather than opposed to - numerical methods. While the introduction of this set of emerging technologies is enabling soil science from different points of view, its successful implementation depends on the ability of soil scientists to act as knowledge brokers and support numerical methods.

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

PubMed Central

Gold, Larry; Ayers, Deborah; Bertino, Jennifer; Bock, Christopher; Bock, Ashley; Brody, Edward N.; Carter, Jeff; Dalby, Andrew B.; Eaton, Bruce E.; Fitzwater, Tim; Flather, Dylan; Forbes, Ashley; Foreman, Trudi; Fowler, Cate; Gawande, Bharat; Goss, Meredith; Gunn, Magda; Gupta, Shashi; Halladay, Dennis; Heil, Jim; Heilig, Joe; Hicke, Brian; Husar, Gregory; Janjic, Nebojsa; Jarvis, Thale; Jennings, Susan; Katilius, Evaldas; Keeney, Tracy R.; Kim, Nancy; Koch, Tad H.; Kraemer, Stephan; Kroiss, Luke; Le, Ngan; Levine, Daniel; Lindsey, Wes; Lollo, Bridget; Mayfield, Wes; Mehan, Mike; Mehler, Robert; Nelson, Sally K.; Nelson, Michele; Nieuwlandt, Dan; Nikrad, Malti; Ochsner, Urs; Ostroff, Rachel M.; Otis, Matt; Parker, Thomas; Pietrasiewicz, Steve; Resnicow, Daniel I.; Rohloff, John; Sanders, Glenn; Sattin, Sarah; Schneider, Daniel; Singer, Britta; Stanton, Martin; Sterkel, Alana; Stewart, Alex; Stratford, Suzanne; Vaught, Jonathan D.; Vrkljan, Mike; Walker, Jeffrey J.; Watrobka, Mike; Waugh, Sheela; Weiss, Allison; Wilcox, Sheri K.; Wolfson, Alexey; Wolk, Steven K.; Zhang, Chi; Zichi, Dom

2010-01-01

Background The interrogation of proteomes (“proteomics”) in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology and medicine. Methodology/Principal Findings We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 µL of serum or plasma). Our current assay measures 813 proteins with low limits of detection (1 pM median), 7 logs of overall dynamic range (∼100 fM–1 µM), and 5% median coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding signature of DNA aptamer concentrations, which is quantified on a DNA microarray. Our assay takes advantage of the dual nature of aptamers as both folded protein-binding entities with defined shapes and unique nucleotide sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to rapidly discover unique protein signatures characteristic of various disease states. Conclusions/Significance We describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine. PMID:21165148

Aptamer-based multiplexed proteomic technology for biomarker discovery.

PubMed

Gold, Larry; Ayers, Deborah; Bertino, Jennifer; Bock, Christopher; Bock, Ashley; Brody, Edward N; Carter, Jeff; Dalby, Andrew B; Eaton, Bruce E; Fitzwater, Tim; Flather, Dylan; Forbes, Ashley; Foreman, Trudi; Fowler, Cate; Gawande, Bharat; Goss, Meredith; Gunn, Magda; Gupta, Shashi; Halladay, Dennis; Heil, Jim; Heilig, Joe; Hicke, Brian; Husar, Gregory; Janjic, Nebojsa; Jarvis, Thale; Jennings, Susan; Katilius, Evaldas; Keeney, Tracy R; Kim, Nancy; Koch, Tad H; Kraemer, Stephan; Kroiss, Luke; Le, Ngan; Levine, Daniel; Lindsey, Wes; Lollo, Bridget; Mayfield, Wes; Mehan, Mike; Mehler, Robert; Nelson, Sally K; Nelson, Michele; Nieuwlandt, Dan; Nikrad, Malti; Ochsner, Urs; Ostroff, Rachel M; Otis, Matt; Parker, Thomas; Pietrasiewicz, Steve; Resnicow, Daniel I; Rohloff, John; Sanders, Glenn; Sattin, Sarah; Schneider, Daniel; Singer, Britta; Stanton, Martin; Sterkel, Alana; Stewart, Alex; Stratford, Suzanne; Vaught, Jonathan D; Vrkljan, Mike; Walker, Jeffrey J; Watrobka, Mike; Waugh, Sheela; Weiss, Allison; Wilcox, Sheri K; Wolfson, Alexey; Wolk, Steven K; Zhang, Chi; Zichi, Dom

2010-12-07

The interrogation of proteomes ("proteomics") in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology and medicine. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 µL of serum or plasma). Our current assay measures 813 proteins with low limits of detection (1 pM median), 7 logs of overall dynamic range (~100 fM-1 µM), and 5% median coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding signature of DNA aptamer concentrations, which is quantified on a DNA microarray. Our assay takes advantage of the dual nature of aptamers as both folded protein-binding entities with defined shapes and unique nucleotide sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to rapidly discover unique protein signatures characteristic of various disease states. We describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine.

Technology-Enabled and Universally Designed Assessment: Considering Access in Measuring the Achievement of Students with Disabilities--A Foundation for Research

ERIC Educational Resources Information Center

Almond, Patricia; Winter, Phoebe; Cameto, Renee; Russell, Michael; Sato, Edynn; Clarke-Midura, Jody; Torres, Chloe; Haertel, Geneva; Dolan, Robert; Beddow, Peter; Lazarus, Sheryl

2010-01-01

This paper represents one outcome from the "Invitational Research Symposium on Technology-Enabled and Universally Designed Assessments," which examined technology-enabled assessments (TEA) and universal design (UD) as they relate to students with disabilities (SWD). It was developed to stimulate research into TEAs designed to make tests…

Grist : grid-based data mining for astronomy

NASA Technical Reports Server (NTRS)

Jacob, Joseph C.; Katz, Daniel S.; Miller, Craig D.; Walia, Harshpreet; Williams, Roy; Djorgovski, S. George; Graham, Matthew J.; Mahabal, Ashish; Babu, Jogesh; Berk, Daniel E. Vanden;

Development of microgravity, full body functional reach envelope using 3-D computer graphic models and virtual reality technology

NASA Technical Reports Server (NTRS)

Lindsey, Patricia F.

1994-01-01

In microgravity conditions mobility is greatly enhanced and body stability is difficult to achieve. Because of these difficulties, optimum placement and accessibility of objects and controls can be critical to required tasks on board shuttle flights or on the proposed space station. Anthropometric measurement of the maximum reach of occupants of a microgravity environment provide knowledge about maximum functional placement for tasking situations. Calculations for a full body, functional reach envelope for microgravity environments are imperative. To this end, three dimensional computer modeled human figures, providing a method of anthropometric measurement, were used to locate the data points that define the full body, functional reach envelope. Virtual reality technology was utilized to enable an occupant of the microgravity environment to experience movement within the reach envelope while immersed in a simulated microgravity environment.

Grist: Grid-based Data Mining for Astronomy

NASA Astrophysics Data System (ADS)

Jacob, J. C.; Katz, D. S.; Miller, C. D.; Walia, H.; Williams, R. D.; Djorgovski, S. G.; Graham, M. J.; Mahabal, A. A.; Babu, G. J.; vanden Berk, D. E.; Nichol, R.

2005-12-01

The Grist project is developing a grid-technology based system as a research environment for astronomy with massive and complex datasets. This knowledge extraction system will consist of a library of distributed grid services controlled by a workflow system, compliant with standards emerging from the grid computing, web services, and virtual observatory communities. This new technology is being used to find high redshift quasars, study peculiar variable objects, search for transients in real time, and fit SDSS QSO spectra to measure black hole masses. Grist services are also a component of the ``hyperatlas'' project to serve high-resolution multi-wavelength imagery over the Internet. In support of these science and outreach objectives, the Grist framework will provide the enabling fabric to tie together distributed grid services in the areas of data access, federation, mining, subsetting, source extraction, image mosaicking, statistics, and visualization.

Space Technology Demo at NASA Wallops

NASA Image and Video Library

2017-12-08

A Black Brant IX suborbital sounding rocket is launched at 7:07 p.m., Wednesday October 7, 2015. (NASA Photo/A. Stancil) A Black Brant IX suborbital rocket was launched from NASA's Wallops Flight Facility. The launch occurred at 7:07 p.m. The primary purpose of the flight was to test the performance of the second-stage Black Brant motor. Preliminary indications are that the motor performed as planned. Preliminary data analysis of the technology experiments (vapor tracer deployments) on the payload is in progress. NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Space Technology Demo at NASA Wallops

NASA Image and Video Library

2017-12-08

A Black Brant IX suborbital sounding rocket is launched at 7:07 p.m., Wednesday October 7, 2015. (NASA Photo/T. Zaperach) A Black Brant IX suborbital rocket was launched from NASA's Wallops Flight Facility. The launch occurred at 7:07 p.m. The primary purpose of the flight was to test the performance of the second-stage Black Brant motor. Preliminary indications are that the motor performed as planned. Preliminary data analysis of the technology experiments (vapor tracer deployments) on the payload is in progress. NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

SubTec-7 Gives New Technologies a Flight Test

NASA Image and Video Library

2017-12-08

NASA successfully launched the SubTec-7 payload on a Black Brant IX suborbital sounding rocket at 5:45 a.m. EDT, May 16, from the NASA's Wallops Flight Facility. The payload flew to an altitude of about 154 miles before descending by parachute and landing in the Atlantic Ocean. SubTec-7 provided a flight test for more than 20 technologies to improve sounding rocket and spacecraft capabilities. Good data was received during the flight. The payload has been recovered. Credit: NASA/Wallops NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Planning For Multiple NASA Missions With Use Of Enabling Radioisotope Power

DOE Office of Scientific and Technical Information (OSTI.GOV)

S.G. Johnson; K.L. Lively; C.C. Dwight

Since the early 1960’s the Department of Energy (DOE) and its predecessor agencies have provided radioisotope power systems (RPS) to NASA as an enabling technology for deep space and various planetary missions. They provide reliable power in situations where solar and/or battery power sources are either untenable or would place an undue mass burden on the mission. In the modern era of the past twenty years there has been no time that multiple missions have been considered for launching from Kennedy Space Center (KSC) during the same year. The closest proximity of missions that involved radioisotope power systems would bemore » that of Galileo (October 1989) and Ulysses (October 1990). The closest that involved radioisotope heater units would be the small rovers Spirit and Opportunity (May and July 2003) used in the Mars Exploration Rovers (MER) mission. It can be argued that the rovers sent to Mars in 2003 were essentially a special case since they staged in the same facility and used a pair of small launch vehicles (Delta II). This paper examines constraints on the frequency of use of radioisotope power systems with regard to launching them from Kennedy Space Center using currently available launch vehicles. This knowledge may be useful as NASA plans for its future deep space or planetary missions where radioisotope power systems are used as an enabling technology. Previous descriptions have focused on single mission chronologies and not analyzed the timelines with an emphasis on multiple missions.« less

Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay.

PubMed

Schumacher, Soeren; Sartorius, Dorian; Ehrentreich-Förster, Eva; Bier, Frank F

2012-10-01

Platform technologies for the changing need of diagnostics are one of the main challenges in medical device technology. From one point-of-view the demand for new and more versatile diagnostic is increasing due to a deeper knowledge of biomarkers and their combination with diseases. From another point-of-view a decentralization of diagnostics will occur since decisions can be made faster resulting in higher success of therapy. Hence, new types of technologies have to be established which enables a multiparameter analysis at the point-of-care. Within this review-like article a system called Fraunhofer ivD-platform is introduced. It consists of a credit-card sized cartridge with integrated reagents, sensors and pumps and a read-out/processing unit. Within the cartridge the assay runs fully automated within 15-20 minutes. Due to the open design of the platform different analyses such as antibody, serological or DNA-assays can be performed. Specific examples of these three different assay types are given to show the broad applicability of the system.

Causality discovery technology

NASA Astrophysics Data System (ADS)

Chen, M.; Ertl, T.; Jirotka, M.; Trefethen, A.; Schmidt, A.; Coecke, B.; Bañares-Alcántara, R.

2012-11-01

Causality is the fabric of our dynamic world. We all make frequent attempts to reason causation relationships of everyday events (e.g., what was the cause of my headache, or what has upset Alice?). We attempt to manage causality all the time through planning and scheduling. The greatest scientific discoveries are usually about causality (e.g., Newton found the cause for an apple to fall, and Darwin discovered natural selection). Meanwhile, we continue to seek a comprehensive understanding about the causes of numerous complex phenomena, such as social divisions, economic crisis, global warming, home-grown terrorism, etc. Humans analyse and reason causality based on observation, experimentation and acquired a priori knowledge. Today's technologies enable us to make observations and carry out experiments in an unprecedented scale that has created data mountains everywhere. Whereas there are exciting opportunities to discover new causation relationships, there are also unparalleled challenges to benefit from such data mountains. In this article, we present a case for developing a new piece of ICT, called Causality Discovery Technology. We reason about the necessity, feasibility and potential impact of such a technology.

Smart systems and personalized health: the real challenge of bridging the innovation gap.

PubMed

Lymberis, Andreas

2014-01-01

Smart miniaturized systems, emerging from the integration of heterogeneous technologies like micro- and nano electronics, photonics, biotechnology, materials and information & communication technologies are considered today, after two decades of intensive public support, proven concepts and functional prototypes, as key enablers opening up new opportunities for healthcare and in particular personalized health. They offer an enhanced ability to sense, detect, analyze, communicate, respond, and monitor phenomena from macro (e.g. body, tissues) to nano scale (e.g. molecules, genes). For the majority of these projects, planning for the next phase of prototype validation, product design, supply chain, user targeting, clinical validation and commercial roll-out are now taking full attention. The new EU Framework Program for Research and Innovation, Horizon 2020, is focusing on technology transfer support and building ecosystems and value chains to ensure better time to market and higher impact of knowledge-based technologies. The state-of-the-art and upcoming challenges for the implementation of H2020 and new opportunities in smart systems for pHealth are discussed in the paper.

Incorporating Service-Learning, Technology, and Research Supportive Teaching Techniques into the University Chemistry Classroom

NASA Astrophysics Data System (ADS)

Saitta, E. K. H.; Bowdon, M. A.; Geiger, C. L.

2011-12-01

Technology was integrated into service-learning activities to create an interactive teaching method for undergraduate students at a large research institution. Chemistry students at the University of Central Florida partnered with high school students at Crooms Academy of Information Technology in interactive service learning projects. The projects allowed UCF students to teach newly acquired content knowledge and build upon course lecture and lab exercises. Activities utilized the web-conferencing tool Adobe Connect Pro to enable interaction with high school students, many of whom have limited access to supplemental educational opportunities due to low socioeconomic status. Seventy chemistry I students created lessons to clarify high school students' misconceptions through the use of refutational texts. In addition, 21 UCF students enrolled in the chemistry II laboratory course acted as virtual lab partners with Crooms students in an interactive guided inquiry experiment focused on chemical kinetics. An overview of project's design, implementation, and assessments are detailed in the case study and serve as a model for future community partnerships. Emerging technologies are emphasized as well as a suggested set of best practices for future projects.

CRISPR-Cas9 technology: applications and human disease modelling.

PubMed

Torres-Ruiz, Raul; Rodriguez-Perales, Sandra

2017-01-01

Genome engineering is a powerful tool for a wide range of applications in biomedical research and medicine. The development of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system has revolutionized the field of gene editing, thus facilitating efficient genome editing through the creation of targeted double-strand breaks of almost any organism and cell type. In addition, CRISPR-Cas9 technology has been used successfully for many other purposes, including regulation of endogenous gene expression, epigenome editing, live-cell labelling of chromosomal loci, edition of single-stranded RNA and high-throughput gene screening. The implementation of the CRISPR-Cas9 system has increased the number of available technological alternatives for studying gene function, thus enabling generation of CRISPR-based disease models. Although many mechanistic questions remain to be answered and several challenges have yet to be addressed, the use of CRISPR-Cas9-based genome engineering technologies will increase our knowledge of disease processes and their treatment in the near future. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PanGEA: identification of allele specific gene expression using the 454 technology.

PubMed

Kofler, Robert; Teixeira Torres, Tatiana; Lelley, Tamas; Schlötterer, Christian

2009-05-14

Next generation sequencing technologies hold great potential for many biological questions. While mainly used for genomic sequencing, they are also very promising for gene expression profiling. Sequencing of cDNA does not only provide an estimate of the absolute expression level, it can also be used for the identification of allele specific gene expression. We developed PanGEA, a tool which enables a fast and user-friendly analysis of allele specific gene expression using the 454 technology. PanGEA allows mapping of 454-ESTs to genes or whole genomes, displaying gene expression profiles, identification of SNPs and the quantification of allele specific gene expression. The intuitive GUI of PanGEA facilitates a flexible and interactive analysis of the data. PanGEA additionally implements a modification of the Smith-Waterman algorithm which deals with incorrect estimates of homopolymer length as occuring in the 454 technology To our knowledge, PanGEA is the first tool which facilitates the identification of allele specific gene expression. PanGEA is distributed under the Mozilla Public License and available at: http://www.kofler.or.at/bioinformatics/PanGEA

PanGEA: Identification of allele specific gene expression using the 454 technology

PubMed Central

Kofler, Robert; Teixeira Torres, Tatiana; Lelley, Tamas; Schlötterer, Christian

2009-01-01

Background Next generation sequencing technologies hold great potential for many biological questions. While mainly used for genomic sequencing, they are also very promising for gene expression profiling. Sequencing of cDNA does not only provide an estimate of the absolute expression level, it can also be used for the identification of allele specific gene expression. Results We developed PanGEA, a tool which enables a fast and user-friendly analysis of allele specific gene expression using the 454 technology. PanGEA allows mapping of 454-ESTs to genes or whole genomes, displaying gene expression profiles, identification of SNPs and the quantification of allele specific gene expression. The intuitive GUI of PanGEA facilitates a flexible and interactive analysis of the data. PanGEA additionally implements a modification of the Smith-Waterman algorithm which deals with incorrect estimates of homopolymer length as occuring in the 454 technology Conclusion To our knowledge, PanGEA is the first tool which facilitates the identification of allele specific gene expression. PanGEA is distributed under the Mozilla Public License and available at: PMID:19442283

Omics Approaches for the Study of Adaptive Immunity to Staphylococcus aureus and the Selection of Vaccine Candidates

PubMed Central

Holtfreter, Silva; Kolata, Julia; Stentzel, Sebastian; Bauerfeind, Stephanie; Schmidt, Frank; Sundaramoorthy, Nandakumar; Bröker, Barbara M.

2016-01-01

Staphylococcus aureus is a dangerous pathogen both in hospitals and in the community. Due to the crisis of antibiotic resistance, there is an urgent need for new strategies to combat S. aureus infections, such as vaccination. Increasing our knowledge about the mechanisms of protection will be key for the successful prevention or treatment of S. aureus invasion. Omics technologies generate a comprehensive picture of the physiological and pathophysiological processes within cells, tissues, organs, organisms and even populations. This review provides an overview of the contribution of genomics, transcriptomics, proteomics, metabolomics and immunoproteomics to the current understanding of S. aureus‑host interaction, with a focus on the adaptive immune response to the microorganism. While antibody responses during colonization and infection have been analyzed in detail using immunoproteomics, the full potential of omics technologies has not been tapped yet in terms of T-cells. Omics technologies promise to speed up vaccine development by enabling reverse vaccinology approaches. In consequence, omics technologies are powerful tools for deepening our understanding of the “superbug” S. aureus and for improving its control. PMID:28248221

A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine.

PubMed

Kawamoto, Kensaku; Lobach, David F; Willard, Huntington F; Ginsburg, Geoffrey S

2009-03-23

In recent years, the completion of the Human Genome Project and other rapid advances in genomics have led to increasing anticipation of an era of genomic and personalized medicine, in which an individual's health is optimized through the use of all available patient data, including data on the individual's genome and its downstream products. Genomic and personalized medicine could transform healthcare systems and catalyze significant reductions in morbidity, mortality, and overall healthcare costs. Critical to the achievement of more efficient and effective healthcare enabled by genomics is the establishment of a robust, nationwide clinical decision support infrastructure that assists clinicians in their use of genomic assays to guide disease prevention, diagnosis, and therapy. Requisite components of this infrastructure include the standardized representation of genomic and non-genomic patient data across health information systems; centrally managed repositories of computer-processable medical knowledge; and standardized approaches for applying these knowledge resources against patient data to generate and deliver patient-specific care recommendations. Here, we provide recommendations for establishing a national decision support infrastructure for genomic and personalized medicine that fulfills these needs, leverages existing resources, and is aligned with the Roadmap for National Action on Clinical Decision Support commissioned by the U.S. Office of the National Coordinator for Health Information Technology. Critical to the establishment of this infrastructure will be strong leadership and substantial funding from the federal government. A national clinical decision support infrastructure will be required for reaping the full benefits of genomic and personalized medicine. Essential components of this infrastructure include standards for data representation; centrally managed knowledge repositories; and standardized approaches for leveraging these knowledge repositories to generate patient-specific care recommendations at the point of care.

Significances of Multimedia Technologies Training

NASA Astrophysics Data System (ADS)

Zhang, Fulei

The use of multimedia technologies in education has enabled teachers to simulate final outcomes and assist s-tudents in applying knowledge learned from textbooks, thereby compensating for the deficiency of traditional teach- ing methods. It is important to examine how effective these technologies are in practical use. This study developed online learning-teaching resource platforms using Flash multimedia, providing interactive and integrated features in an easy-to-use user interface, in order to discuss Computer-Aided Drawing (CAD). The study utilized a teaching experiment with a non-equivalent pretest-posttest control group design to test and discuss students' professional cognition, operating skill cognition, and level of learning satisfaction during the learning process. No significant differences emerged between the groups in regards to professional cognition or operation skills cognition. However, a significant difference in learning satisfaction was noted, indicating that the coursework with multimedia Flash produced greater satisfaction than with traditional learning methods. Results are explained in detail and recommendations for further research provided.

Solar Sail Propulsion: Enabling New Capabilities for Heliophysics

NASA Technical Reports Server (NTRS)

Johnson, L.; Young, R.; Alhorn, D.; Heaton, A.; Vansant, T.; Campbell, B.; Pappa, R.; Keats, W.; Liewer, P. C.; Alexander, D.;

The Energy Forum of Sri Lanka: Working toward appropriate expertise

NASA Astrophysics Data System (ADS)

Nieusma, Dean

Taking my cue from the knowledge base and practices comprising appropriate technology development, and building on politics of expertise scholarship, this dissertation develops the concept of appropriate expertise: the combination of social and technical competences required to address marginalization through technological interventions. The dissertation asks what appropriate expertise looks like "on the ground" in the context of development as practiced by an exceptional group of technology designers from the Energy Forum of Sri Lanka: What design goals did they strive toward? What challenges did they face? What strategies did they employ? In an effort to answer these questions, the dissertation looks at how these designers interacted across a range of contexts with a broad spectrum of people and institutions, each with its own expertise to draw upon. In particular, it looks at how they situated their work in a highly contoured field of social power, where different types of expertise were used as resources for reinforcing or resisting existing power relations. I use the concept relations of expertise to denote the structure of expert interactions across multiple contexts of activity. Although this concept links to broad political-economic conditions that order varied expert practices, my analytic focus is at a different level: the situated experiences of expert practitioners. By starting with ground-level practices and understandings, I argue that creating new relations of expertise---that is, changing the nature of the interactions among experts and between experts and those they work with---is the key way my informants worked to legitimate marginalized perspectives and thereby empower marginalized social groups around technology-development practices. Appropriate expertise enables the creation of appropriate technologies, but it does more. It enables the creation of new relations of expertise, both through inspiring new forms of interpersonal interaction surrounding technology development and through incremental modification of existing decision-making structures to allow a more diverse group stakeholders to come together around technology decision making in the context of development.

Central Component Descriptors for Levels of Technological Pedagogical Content Knowledge

ERIC Educational Resources Information Center

Niess, Margaret L.

2013-01-01

Technological pedagogical content knowledge (TPACK) proposes a theoretical framework that incorporates four central components: an overarching conception of what it means to teach with technology, knowledge of students' thinking and understandings of specific topics with technologies, knowledge of curricular materials that incorporate…

Cryogenic Fluid Technologies for Long Duration In-Space Operations

NASA Technical Reports Server (NTRS)

Motil, Susan M.; Tramel, Terri L.

2008-01-01

Reliable knowledge of low-gravity cryogenic fluid management behavior is lacking and yet is critical in the areas of storage, distribution, and low-gravity propellant management. The Vision for Space Exploration mission objectives will require the use of high performance cryogenic propellants (hydrogen, oxygen, and methane). Additionally, lunar missions will require success in storing and transferring liquid and gas commodities on the surface. The fundamental challenges associated with the in-space use of cryogens are their susceptibility to environmental heat, their complex thermodynamic and fluid dynamic behavior in low gravity and the uncertainty of the position of the liquid-vapor interface if the propellants are not settled. The Cryogenic Fluid Management (CFM) project is addressing these issues through ground testing and analytical model development, and has crosscutting applications and benefits to virtually all missions requiring in-space operations with cryogens. Such knowledge can significantly reduce or even eliminate tank fluid boil-off losses for long term missions, reduce propellant launch mass and on-orbit margins, and simplify vehicle operations. The Cryogenic Fluid Management (CFM) Project is conducting testing and performing analytical evaluation of several areas to enable NASA s Exploration Vision. This paper discusses the content and progress of the technology focus areas within CFM.

An industrial approach to design compelling VR and AR experience

NASA Astrophysics Data System (ADS)

Richir, Simon; Fuchs, Philippe; Lourdeaux, Domitile; Buche, Cédric; Querrec, Ronan

2013-03-01

The convergence of technologies currently observed in the field of VR, AR, robotics and consumer electronic reinforces the trend of new applications appearing every day. But when transferring knowledge acquired from research to businesses, research laboratories are often at a loss because of a lack of knowledge of the design and integration processes in creating an industrial scale product. In fact, the innovation approaches that take a good idea from the laboratory to a successful industrial product are often little known to researchers. The objective of this paper is to present the results of the work of several research teams that have finalized a working method for researchers and manufacturers that allow them to design virtual or augmented reality systems and enable their users to enjoy "a compelling VR experience". That approach, called "the I2I method", present 11 phases from "Establishing technological and competitive intelligence and industrial property" to "Improvements" through the "Definition of the Behavioral Interface, Virtual Environment and Behavioral Software Assistance". As a result of the experience gained by various research teams, this design approach benefits from contributions from current VR and AR research. Our objective is to validate and continuously move such multidisciplinary design team methods forward.

Organizational culture and knowledge management in the electric power generation industry

NASA Astrophysics Data System (ADS)

Mayfield, Robert D.

Scarcity of knowledge and expertise is a challenge in the electric power generation industry. Today's most pervasive knowledge issues result from employee turnover and the constant movement of employees from project to project inside organizations. To address scarcity of knowledge and expertise, organizations must enable employees to capture, transfer, and use mission-critical explicit and tacit knowledge. The purpose of this qualitative grounded theory research was to examine the relationship between and among organizations within the electric power generation industry developing knowledge management processes designed to retain, share, and use the industry, institutional, and technical knowledge upon which the organizations depend. The research findings show that knowledge management is a business problem within the domain of information systems and management. The risks associated with losing mission critical-knowledge can be measured using metrics on employee retention, recruitment, productivity, training and benchmarking. Certain enablers must be in place in order to engage people, encourage cooperation, create a knowledge-sharing culture, and, ultimately change behavior. The research revealed the following change enablers that support knowledge management strategies: (a) training - blended learning, (b) communities of practice, (c) cross-functional teams, (d) rewards and recognition programs, (e) active senior management support, (f) communication and awareness, (g) succession planning, and (h) team organizational culture.

Health-Enabling and Ambient Assistive Technologies: Past, Present, Future.

PubMed

Haux, R; Koch, S; Lovell, N H; Marschollek, M; Nakashima, N; Wolf, K-H

2016-06-30

During the last decades, health-enabling and ambient assistive technologies became of considerable relevance for new informatics-based forms of diagnosis, prevention, and therapy. To describe the state of the art of health-enabling and ambient assistive technologies in 1992 and today, and its evolution over the last 25 years as well as to project where the field is expected to be in the next 25 years. In the context of this review, we define health-enabling and ambient assistive technologies as ambiently used sensor-based information and communication technologies, aiming at contributing to a person's health and health care as well as to her or his quality of life. Systematic review of all original articles with research focus in all volumes of the IMIA Yearbook of Medical Informatics. Surveying authors independently on key projects and visions as well as on their lessons learned in the context of health-enabling and ambient assistive technologies and summarizing their answers. Surveying authors independently on their expectations for the future and summarizing their answers. IMIA Yearbook papers containing statements on health-enabling and ambient assistive technologies appear first in 2002. These papers form a minor part of published research articles in medical informatics. However, during recent years the number of articles published has increased significantly. Key projects were identified. There was a clear progress on the use of technologies. However proof of diagnostic relevance and therapeutic efficacy remains still limited. Reforming health care processes and focussing more on patient needs are required. Health-enabling and ambient assistive technologies remain an important field for future health care and for interdisciplinary research. More and more publications assume that a person's home and their interaction therein, are becoming important components in health care provision, assessment, and management.

Health-Enabling and Ambient Assistive Technologies: Past, Present, Future

PubMed Central

2016-01-01

Summary Background During the last decades, health-enabling and ambient assistive technologies became of considerable relevance for new informatics-based forms of diagnosis, prevention, and therapy. Objectives To describe the state of the art of health-enabling and ambient assistive technologies in 1992 and today, and its evolution over the last 25 years as well as to project where the field is expected to be in the next 25 years. In the context of this review, we define health-enabling and ambient assistive technologies as ambiently used sensor-based information and communication technologies, aiming at contributing to a person’s health and health care as well as to her or his quality of life. Methods Systematic review of all original articles with research focus in all volumes of the IMIA Yearbook of Medical Informatics. Surveying authors independently on key projects and visions as well as on their lessons learned in the context of health-enabling and ambient assistive technologies and summarizing their answers. Surveying authors independently on their expectations for the future and summarizing their answers. Results IMIA Yearbook papers containing statements on health-enabling and ambient assistive technologies appear first in 2002. These papers form a minor part of published research articles in medical informatics. However, during recent years the number of articles published has increased significantly. Key projects were identified. There was a clear progress on the use of technologies. However proof of diagnostic relevance and therapeutic efficacy remains still limited. Reforming health care processes and focussing more on patient needs are required. Conclusions Health-enabling and ambient assistive technologies remain an important field for future health care and for interdisciplinary research. More and more publications assume that a person‘s home and their interaction therein, are becoming important components in health care provision, assessment, and management. PMID:27362588

Development of Pre-Service Chemistry Teachers' Technological Pedagogical Content Knowledge

ERIC Educational Resources Information Center

Cetin-Dindar, Ayla; Boz, Yezdan; Sonmez, Demet Yildiran; Celep, Nilgun Demirci

2018-01-01

In this study, a mixed-method design was employed to investigate pre-service chemistry teachers' Technological Pedagogical Content Knowledge (TPACK) development. For effective technology integration in instruction, knowledge about technology is not enough; teachers should have different knowledge types which are content, pedagogical, and…

Qualification and issues with space flight laser systems and components

NASA Astrophysics Data System (ADS)

Ott, Melanie N.; Coyle, D. B.; Canham, John S.; Leidecker, Henning W., Jr.

2006-02-01

The art of flight quality solid-state laser development is still relatively young, and much is still unknown regarding the best procedures, components, and packaging required for achieving the maximum possible lifetime and reliability when deployed in the harsh space environment. One of the most important issues is the limited and unstable supply of quality, high power diode arrays with significant technological heritage and market lifetime. Since Spectra Diode Labs Inc. ended their involvement in the pulsed array business in the late 1990's, there has been a flurry of activity from other manufacturers, but little effort focused on flight quality production. This forces NASA, inevitably, to examine the use of commercial parts to enable space flight laser designs. System-level issues such as power cycling, operational derating, duty cycle, and contamination risks to other laser components are some of the more significant unknown, if unquantifiable, parameters that directly effect transmitter reliability. Designs and processes can be formulated for the system and the components (including thorough modeling) to mitigate risk based on the known failures modes as well as lessons learned that GSFC has collected over the past ten years of space flight operation of lasers. In addition, knowledge of the potential failure modes related to the system and the components themselves can allow the qualification testing to be done in an efficient yet, effective manner. Careful test plan development coupled with physics of failure knowledge will enable cost effect qualification of commercial technology. Presented here will be lessons learned from space flight experience, brief synopsis of known potential failure modes, mitigation techniques, and options for testing from the system level to the component level.

A research agenda for helminth diseases of humans: basic research and enabling technologies to support control and elimination of helminthiases.

PubMed

Lustigman, Sara; Geldhof, Peter; Grant, Warwick N; Osei-Atweneboana, Mike Y; Sripa, Banchob; Basáñez, María-Gloria

2012-01-01

Successful and sustainable intervention against human helminthiases depends on optimal utilisation of available control measures and development of new tools and strategies, as well as an understanding of the evolutionary implications of prolonged intervention on parasite populations and those of their hosts and vectors. This will depend largely on updated knowledge of relevant and fundamental parasite biology. There is a need, therefore, to exploit and apply new knowledge and techniques in order to make significant and novel gains in combating helminthiases and supporting the sustainability of current and successful mass drug administration (MDA) programmes. Among the fields of basic research that are likely to yield improved control tools, the Disease Reference Group on Helminth Infections (DRG4) has identified four broad areas that stand out as central to the development of the next generation of helminth control measures: 1) parasite genetics, genomics, and functional genomics; 2) parasite immunology; 3) (vertebrate) host-parasite interactions and immunopathology; and 4) (invertebrate) host-parasite interactions and transmission biology. The DRG4 was established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR). The Group was given the mandate to undertake a comprehensive review of recent advances in helminthiases research in order to identify notable gaps and highlight priority areas. This paper summarises recent advances and discusses challenges in the investigation of the fundamental biology of those helminth parasites under the DRG4 Group's remit according to the identified priorities, and presents a research and development agenda for basic parasite research and enabling technologies that will help support control and elimination efforts against human helminthiases.

Human Research Program Integrated Research Plan. Revision A January 2009

NASA Technical Reports Server (NTRS)

2009-01-01

The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

Qualification and Issues with Space Flight Laser Systems and Components

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Coyle, D. Barry; Canham, John S.; Leidecker, Henning W.

2006-01-01

The art of flight quality solid-state laser development is still relatively young, and much is still unknown regarding the best procedures, components, and packaging required for achieving the maximum possible lifetime and reliability when deployed in the harsh space environment. One of the most important issues is the limited and unstable supply of quality, high power diode arrays with significant technological heritage and market lifetime. Since Spectra Diode Labs Inc. ended their involvement in the pulsed array business in the late 1990's, there has been a flurry of activity from other manufacturers, but little effort focused on flight quality production. This forces NASA, inevitably, to examine the use of commercial parts to enable space flight laser designs. System-level issues such as power cycling, operational derating, duty cycle, and contamination risks to other laser components are some of the more significant unknown, if unquantifiable, parameters that directly effect transmitter reliability. Designs and processes can be formulated for the system and the components (including thorough modeling) to mitigate risk based on the known failures modes as well as lessons learned that GSFC has collected over the past ten years of space flight operation of lasers. In addition, knowledge of the potential failure modes related to the system and the components themselves can allow the qualification testing to be done in an efficient yet, effective manner. Careful test plan development coupled with physics of failure knowledge will enable cost effect qualification of commercial technology. Presented here will be lessons learned from space flight experience, brief synopsis of known potential failure modes, mitigation techniques, and options for testing from the system level to the component level.

Qualification and Issues with Space Flight Laser Systems and Components

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Coyle, D. Barry; Canham, John S.; Leidecker, Henning W.

2006-01-01

The art of flight quality solid-state laser development is still relatively young, and much is still unknown regarding the best procedures, components, and packaging required for achieving the maximum possible lifetime and reliability when deployed in the harsh space environment. One of the most important issues is the limited and unstable supply of quality, high power diode arrays with significant technological heritage and market lifetime. Since Spectra Diode Labs Inc. ended their involvement in the pulsed array business in the late 199O's, there has been a flurry of activity from other manufacturers, but little effort focused on flight quality production. This forces NASA, inevitably, to examine the use of commercial parts to enable space flight laser designs. System-level issues such as power cycling, operational derating, duty cycle, and contamination risks to other laser components are some of the more significant unknown, if unquantifiable, parameters that directly effect transmitter reliability. Designs and processes can be formulated for the system and the components (including thorough modeling) to mitigate risk based on the known failures modes as well as lessons learned that GSFC has collected over the past ten years of space flight operation of lasers. In addition, knowledge of the potential failure modes related to the system and the components themselves can allow the qualification testing to be done in an efficient yet, effective manner. Careful test plan development coupled with physics of failure knowledge will enable cost effect qualification of commercial technology. Presented here will be lessons learned from space flight experience, brief synopsis of known potential failure modes, mitigation techniques, and options for testing from the system level to the component level.

How Technology Teachers Understand Technological Knowledge

ERIC Educational Resources Information Center

Norström, Per

2014-01-01

Swedish technology teachers' views of technological knowledge are examined through a written survey and a series of interviews. The study indicates that technology teachers' understandings of what constitutes technological knowledge and how it is justified vary considerably. The philosophical discussions on the topic are unknown to them. This lack…

Emerging Research and Clinical Development Trends of Liposome and Lipid Nanoparticle Drug Delivery Systems

PubMed Central

KRAFT, JOHN C.; FREELING, JENNIFER P.; WANG, ZIYAO; HO, RODNEY J. Y.

2014-01-01

Liposomes are spherical-enclosed membrane vesicles mainly constructed with lipids. Lipid nanoparticles are loaded with therapeutics and may not contain an enclosed bilayer. The majority of those clinically approved have diameters of 50–300 nm. The growing interest in nanomedicine has fueled lipid–drug and lipid–protein studies, which provide a foundation for developing lipid particles that improve drug potency and reduce off-target effects. Integrating advances in lipid membrane research has enabled therapeutic development. At present, about 600 clinical trials involve lipid particle drug delivery systems. Greater understanding of pharmacokinetics, biodistribution, and disposition of lipid–drug particles facilitated particle surface hydration technology (with polyethylene glycol) to reduce rapid clearance and provide sufficient blood circulation time for drug to reach target tissues and cells. Surface hydration enabled the liposome-encapsulated cancer drug doxorubicin (Doxil) to gain clinical approval in 1995. Fifteen lipidic therapeutics are now clinically approved. Although much research involves attaching lipid particles to ligands selective for occult cells and tissues, preparation procedures are often complex and pose scale-up challenges. With emerging knowledge in drug target and lipid–drug distribution in the body, a systems approach that integrates knowledge to design and scale lipid–drug particles may further advance translation of these systems to improve therapeutic safety and efficacy. PMID:24338748

JSC Advanced Curation: Research and Development for Current Collections and Future Sample Return Mission Demands

NASA Technical Reports Server (NTRS)

Fries, M. D.; Allen, C. C.; Calaway, M. J.; Evans, C. A.; Stansbery, E. K.

2015-01-01

Curation of NASA's astromaterials sample collections is a demanding and evolving activity that supports valuable science from NASA missions for generations, long after the samples are returned to Earth. For example, NASA continues to loan hundreds of Apollo program samples to investigators every year and those samples are often analyzed using instruments that did not exist at the time of the Apollo missions themselves. The samples are curated in a manner that minimizes overall contamination, enabling clean, new high-sensitivity measurements and new science results over 40 years after their return to Earth. As our exploration of the Solar System progresses, upcoming and future NASA sample return missions will return new samples with stringent contamination control, sample environmental control, and Planetary Protection requirements. Therefore, an essential element of a healthy astromaterials curation program is a research and development (R&D) effort that characterizes and employs new technologies to maintain current collections and enable new missions - an Advanced Curation effort. JSC's Astromaterials Acquisition & Curation Office is continually performing Advanced Curation research, identifying and defining knowledge gaps about research, development, and validation/verification topics that are critical to support current and future NASA astromaterials sample collections. The following are highlighted knowledge gaps and research opportunities.

Smart Interpretation - Application of Machine Learning in Geological Interpretation of AEM Data

NASA Astrophysics Data System (ADS)

Bach, T.; Gulbrandsen, M. L.; Jacobsen, R.; Pallesen, T. M.; Jørgensen, F.; Høyer, A. S.; Hansen, T. M.

2015-12-01

When using airborne geophysical measurements in e.g. groundwater mapping, an overwhelming amount of data is collected. Increasingly larger survey areas, denser data collection and limited resources, combines to an increasing problem of building geological models that use all the available data in a manner that is consistent with the geologists knowledge about the geology of the survey area. In the ERGO project, funded by The Danish National Advanced Technology Foundation, we address this problem, by developing new, usable tools, enabling the geologist utilize her geological knowledge directly in the interpretation of the AEM data, and thereby handle the large amount of data, In the project we have developed the mathematical basis for capturing geological expertise in a statistical model. Based on this, we have implemented new algorithms that have been operationalized and embedded in user friendly software. In this software, the machine learning algorithm, Smart Interpretation, enables the geologist to use the system as an assistant in the geological modelling process. As the software 'learns' the geology from the geologist, the system suggest new modelling features in the data. In this presentation we demonstrate the application of the results from the ERGO project, including the proposed modelling workflow utilized on a variety of data examples.

Human Research Program Integrated Research Plan. Revision C

NASA Technical Reports Server (NTRS)

Steinberg, Susan

2011-01-01

Crew health and performance are critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes (1) HRP's approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and (2) the method of integration for risk mitigation. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

Simultaneous Multiparameter Cellular Energy Metabolism Profiling of Small Populations of Cells.

PubMed

Kelbauskas, Laimonas; Ashili, Shashaanka P; Lee, Kristen B; Zhu, Haixin; Tian, Yanqing; Meldrum, Deirdre R

2018-03-12

Functional and genomic heterogeneity of individual cells are central players in a broad spectrum of normal and disease states. Our knowledge about the role of cellular heterogeneity in tissue and organism function remains limited due to analytical challenges one encounters when performing single cell studies in the context of cell-cell interactions. Information based on bulk samples represents ensemble averages over populations of cells, while data generated from isolated single cells do not account for intercellular interactions. We describe a new technology and demonstrate two important advantages over existing technologies: first, it enables multiparameter energy metabolism profiling of small cell populations (<100 cells)-a sample size that is at least an order of magnitude smaller than other, commercially available technologies; second, it can perform simultaneous real-time measurements of oxygen consumption rate (OCR), extracellular acidification rate (ECAR), and mitochondrial membrane potential (MMP)-a capability not offered by any other commercially available technology. Our results revealed substantial diversity in response kinetics of the three analytes in dysplastic human epithelial esophageal cells and suggest the existence of varying cellular energy metabolism profiles and their kinetics among small populations of cells. The technology represents a powerful analytical tool for multiparameter studies of cellular function.

Application of NASA's Advanced Life Support Technologies for Waste Treatment, Water Purification and Recycle, and Food Production in Polar Regions

NASA Technical Reports Server (NTRS)

Bubenheim, David L.; Lewis, Carol E.; Covington, M. Alan (Technical Monitor)

1995-01-01

NASA's advanced life support technologies are being combined with Arctic science and engineering knowledge to address the unique needs of the remote communities of Alaska through the Advanced Life Systems for Extreme Environments (ALSEE) project. ALSEE is a collaborative effort involving NASA, the State of Alaska, the University of Alaska, the North Slope Borough of Alaska, and the National Science Foundation (NSF). The focus is a major issue in the state of Alaska and other areas of the Circumpolar North, the health and welfare of its people, their lives and the subsistence lifestyle in remote communities, economic opportunity, and care for the environment. The project primarily provides treatment and reduction of waste, purification and recycling of water. and production of food. A testbed is being established to demonstrate the technologies which will enable safe, healthy, and autonomous function of remote communities and to establish the base for commercial development of the resulting technology into new industries. The challenge is to implement the technological capabilities in a manner compatible with the social and economic structures of the native communities, the state, and the commercial sector. Additional information is contained in the original extended abstract.

Discovering Drugs with DNA-Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase.

PubMed

Belyanskaya, Svetlana L; Ding, Yun; Callahan, James F; Lazaar, Aili L; Israel, David I

2017-05-04

DNA-encoded chemical library technology was developed with the vision of its becoming a transformational platform for drug discovery. The hope was that a new paradigm for the discovery of low-molecular-weight drugs would be enabled by combining the vast molecular diversity achievable with combinatorial chemistry, the information-encoding attributes of DNA, the power of molecular biology, and a streamlined selection-based discovery process. Here, we describe the discovery and early clinical development of GSK2256294, an inhibitor of soluble epoxide hydrolase (sEH, EPHX2), by using encoded-library technology (ELT). GSK2256294 is an orally bioavailable, potent and selective inhibitor of sEH that has a long half life and produced no serious adverse events in a first-time-in-human clinical study. To our knowledge, GSK2256294 is the first molecule discovered from this technology to enter human clinical testing and represents a realization of the vision that DNA-encoded chemical library technology can efficiently yield molecules with favorable properties that can be readily progressed into high-quality drugs. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkerson, Andrea M.; McCullough, Jeffrey J.

The Yuma Sector Border Patrol Area is a high flux lighting application in a high temperature environment, presenting a formidable challenge for light-emitting diodes (LEDs). This retrofit is an Energy Savings Performance Contract ENABLE project under the U.S. Department of Energy (DOE) Federal Energy Management Program. If high flux LED technology performs well in a region with high ambient temperature and solar radiation, it can perform well in most outdoor environments. The design process for the Yuma retrofit has already provided valuable knowledge to CBP and DOE. The LED lighting system selected for the retrofit is expected to reduce energymore » consumption 69% compared to the incumbent quartz metal halide (QMH) lighting system. If the LED lighting system is installed, GATEWAY will continue to document and disseminate information regarding the installation and long-term performance so that others may also gain valuable knowledge from the Yuma Sector Border Patrol Area lighting retrofit.« less

Map of Life - A Dashboard for Monitoring Planetary Species Distributions

NASA Astrophysics Data System (ADS)

Jetz, W.

2016-12-01

Geographic information about biodiversity is vital for understanding the many services nature provides and their potential changes, yet remains unreliable and often insufficient. By integrating a wide range of knowledge about species distributions and their dynamics over time, Map of Life supports global biodiversity education, monitoring, research and decision-making. Built on a scalable web platform geared for large biodiversity and environmental data, Map of Life endeavors provides species range information globally and species lists for any area. With data and technology provided by NASA and Google Earth Engine, tools under development use remote sensing-based environmental layers to enable on-the-fly predictions of species distributions, range changes, and early warning signals for threatened species. The ultimate vision is a globally connected, collaborative knowledge- and tool-base for regional and local biodiversity decision-making, education, monitoring, and projection. For currently available tools, more information and to follow progress, go to MOL.org.

Good surgeon: A search for meaning.

PubMed

Akopov, Andrey L; Artioukh, Dmitri Y

2017-01-01

The art and philosophy of surgery are not as often discussed as scientific discoveries and technological advances in the modern era of surgery. Although these are difficult to teach and pass on to the next generations of surgeons they are no less important for training good surgeons and maintaining their high standards. The authors of this review and opinion article tried to define what being a good surgeon really means and to look into the subject by analysing the essential conditions for being a good surgeon and the qualities that such a specialist should possess. In addition to a strong theoretic knowledge and practical skills and among the several described professional and personal characteristics, a good surgeon is expected to have common sense. It enables a surgeon to make a sound practical judgment independent of specialized medical knowledge and training. The possible ways of developing and/or enhancing common sense during surgical training and subsequent practice require separate analysis.

Demand Response Advanced Controls Framework and Assessment of Enabling Technology Costs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Potter, Jennifer; Cappers, Peter

The Demand Response Advanced Controls Framework and Assessment of Enabling Technology Costs research describe a variety of DR opportunities and the various bulk power system services they can provide. The bulk power system services are mapped to a generalized taxonomy of DR “service types”, which allows us to discuss DR opportunities and bulk power system services in fewer yet broader categories that share similar technological requirements which mainly drive DR enablement costs. The research presents a framework for the costs to automate DR and provides descriptions of the various elements that drive enablement costs. The report introduces the various DRmore » enabling technologies and end-uses, identifies the various services that each can provide to the grid and provides the cost assessment for each enabling technology. In addition to a report, this research includes a Demand Response Advanced Controls Database and User Manual. They are intended to provide users with the data that underlies this research and instructions for how to use that database more effectively and efficiently.« less

Gathering and Exploring Scientific Knowledge in Pharmacovigilance

PubMed Central

Lopes, Pedro; Nunes, Tiago; Campos, David; Furlong, Laura Ines; Bauer-Mehren, Anna; Sanz, Ferran; Carrascosa, Maria Carmen; Mestres, Jordi; Kors, Jan; Singh, Bharat; van Mulligen, Erik; Van der Lei, Johan; Diallo, Gayo; Avillach, Paul; Ahlberg, Ernst; Boyer, Scott; Diaz, Carlos; Oliveira, José Luís

2013-01-01

Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this field have been slowing down over the last decade due to miscellaneous legal, ethical and methodological constraints. Pharmaceutical companies started to realize that collaborative and integrative approaches boost current drug research and development processes. Hence, new strategies are required to connect researchers, datasets, biomedical knowledge and analysis algorithms, allowing them to fully exploit the true value behind state-of-the-art pharmacovigilance efforts. This manuscript introduces a new platform directed towards pharmacovigilance knowledge providers. This system, based on a service-oriented architecture, adopts a plugin-based approach to solve fundamental pharmacovigilance software challenges. With the wealth of collected clinical and pharmaceutical data, it is now possible to connect knowledge providers’ analysis and exploration algorithms with real data. As a result, new strategies allow a faster identification of high-risk interactions between marketed drugs and adverse events, and enable the automated uncovering of scientific evidence behind them. With this architecture, the pharmacovigilance field has a new platform to coordinate large-scale drug evaluation efforts in a unique ecosystem, publicly available at http://bioinformatics.ua.pt/euadr/. PMID:24349421

The Faculty Self-Reported Assessment Survey (FRAS): Differentiating Faculty Knowledge and Experience in Assessment

PubMed Central

Hanauer, David I.; Bauerle, Cynthia

2015-01-01

Science, technology, engineering, and mathematics education reform efforts have called for widespread adoption of evidence-based teaching in which faculty members attend to student outcomes through assessment practice. Awareness about the importance of assessment has illuminated the need to understand what faculty members know and how they engage with assessment knowledge and practice. The Faculty Self-Reported Assessment Survey (FRAS) is a new instrument for evaluating science faculty assessment knowledge and experience. Instrument validation was composed of two distinct studies: an empirical evaluation of the psychometric properties of the FRAS and a comparative known-groups validation to explore the ability of the FRAS to differentiate levels of faculty assessment experience. The FRAS was found to be highly reliable (α = 0.96). The dimensionality of the instrument enabled distinction of assessment knowledge into categories of program design, instrumentation, and validation. In the known-groups validation, the FRAS distinguished between faculty groups with differing levels of assessment experience. Faculty members with formal assessment experience self-reported higher levels of familiarity with assessment terms, higher frequencies of assessment activity, increased confidence in conducting assessment, and more positive attitudes toward assessment than faculty members who were novices in assessment. These results suggest that the FRAS can reliably and validly differentiate levels of expertise in faculty knowledge of assessment. PMID:25976653

Semantically-enabled Knowledge Discovery in the Deep Carbon Observatory

NASA Astrophysics Data System (ADS)

Wang, H.; Chen, Y.; Ma, X.; Erickson, J. S.; West, P.; Fox, P. A.

2013-12-01

The Deep Carbon Observatory (DCO) is a decadal effort aimed at transforming scientific and public understanding of carbon in the complex deep earth system from the perspectives of Deep Energy, Deep Life, Extreme Physics and Chemistry, and Reservoirs and Fluxes. Over the course of the decade DCO scientific activities will generate a massive volume of data across a variety of disciplines, presenting significant challenges in terms of data integration, management, analysis and visualization, and ultimately limiting the ability of scientists across disciplines to make insights and unlock new knowledge. The DCO Data Science Team (DCO-DS) is applying Semantic Web methodologies to construct a knowledge representation focused on the DCO Earth science disciplines, and use it together with other technologies (e.g. natural language processing and data mining) to create a more expressive representation of the distributed corpus of DCO artifacts including datasets, metadata, instruments, sensors, platforms, deployments, researchers, organizations, funding agencies, grants and various awards. The embodiment of this knowledge representation is the DCO Data Science Infrastructure, in which unique entities within the DCO domain and the relations between them are recognized and explicitly identified. The DCO-DS Infrastructure will serve as a platform for more efficient and reliable searching, discovery, access, and publication of information and knowledge for the DCO scientific community and beyond.

Enabling the Capture and Sharing of NASA Technical Expertise Through Communities of Practice

NASA Technical Reports Server (NTRS)

Topousis, Daria E.; Dennehy, Cornelius J.; Lebsock, Kenneth L.

2011-01-01

Historically, engineers at the National Aeronautics and Space Administration (NASA) had few opportunities or incentives to share their technical expertise across the Agency. Its center- and project- focused culture often meant that knowledge never left organizational and geographic boundaries. With increasingly complex missions, the closeout of the Shuttle Program, and a new generation entering the workforce, developing a knowledge sharing culture became critical. To address this need, the Office of the Chief Engineer established communities of practice on the NASA Engineering Network. These communities were strategically aligned with NASA's core competencies in such disciplines as avionics, flight mechanics, life support, propulsion, structures, loads and dynamics, human factors, and guidance, navigation, and control. This paper describes the process used to identify and develop communities, from establishing simple websites that compiled discipline-specific resources to fostering a knowledge-sharing environment through collaborative and interactive technologies. It includes qualitative evidence of improved availability and transfer of knowledge. It focuses on pivotal capabilities that increased knowledge exchange such as a custom-made Ask An Expert system, community contact lists, publication of key resources, and submission forms that allowed any user to propose content for the sites. It discusses the peer relationships that developed through the communities and the leadership and infrastructure that made them possible.

Computational neuroanatomy: ontology-based representation of neural components and connectivity.

PubMed

Rubin, Daniel L; Talos, Ion-Florin; Halle, Michael; Musen, Mark A; Kikinis, Ron

2009-02-05

A critical challenge in neuroscience is organizing, managing, and accessing the explosion in neuroscientific knowledge, particularly anatomic knowledge. We believe that explicit knowledge-based approaches to make neuroscientific knowledge computationally accessible will be helpful in tackling this challenge and will enable a variety of applications exploiting this knowledge, such as surgical planning. We developed ontology-based models of neuroanatomy to enable symbolic lookup, logical inference and mathematical modeling of neural systems. We built a prototype model of the motor system that integrates descriptive anatomic and qualitative functional neuroanatomical knowledge. In addition to modeling normal neuroanatomy, our approach provides an explicit representation of abnormal neural connectivity in disease states, such as common movement disorders. The ontology-based representation encodes both structural and functional aspects of neuroanatomy. The ontology-based models can be evaluated computationally, enabling development of automated computer reasoning applications. Neuroanatomical knowledge can be represented in machine-accessible format using ontologies. Computational neuroanatomical approaches such as described in this work could become a key tool in translational informatics, leading to decision support applications that inform and guide surgical planning and personalized care for neurological disease in the future.

Designing high-quality interactive multimedia learning modules.

PubMed

Huang, Camillan

2005-01-01

Modern research has broadened scientific knowledge and revealed the interdisciplinary nature of the sciences. For today's students, this advance translates to learning a more diverse range of concepts, usually in less time, and without supporting resources. Students can benefit from technology-enhanced learning supplements that unify concepts and are delivered on-demand over the Internet. Such supplements, like imaging informatics databases, serve as innovative references for biomedical information, but could improve their interaction interfaces to support learning. With information from these digital datasets, multimedia learning tools can be designed to transform learning into an active process where students can visualize relationships over time, interact with dynamic content, and immediately test their knowledge. This approach bridges knowledge gaps, fosters conceptual understanding, and builds problem-solving and critical thinking skills-all essential components to informatics training for science and medicine. Additional benefits include cost-free access and ease of dissemination over the Internet or CD-ROM. However, current methods for the design of multimedia learning modules are not standardized and lack strong instructional design. Pressure from administrators at the top and students from the bottom are pushing faculty to use modern technology to address the learning needs and expectations of contemporary students. Yet, faculty lack adequate support and training to adopt this new approach. So how can faculty learn to create educational multimedia materials for their students? This paper provides guidelines on best practices in educational multimedia design, derived from the Virtual Labs Project at Stanford University. The development of a multimedia module consists of five phases: (1) understand the learning problem and the users needs; (2) design the content to harness the enabling technologies; (3) build multimedia materials with web style standards and human factors principles; (4) user testing; (5) evaluate and improve design.

Breathing Room in Monitored Space: The Impact of Passive Monitoring Technology on Privacy in Independent Living.

PubMed

Berridge, Clara

2016-10-01

This study examines articulations of the relationship between privacy and passive monitoring by users and former users of a sensor-based remote monitoring system. A new conceptualization of privacy provides a framework for a constructive analysis of the study's findings with practical implications. Forty-nine in-depth semistructured interviews were conducted with elder residents, family members, and staff of 6 low-income independent living residence apartment buildings where the passive monitoring system had been offered for 6 years. Transcribed interviews were coded into the Dedoose software service and were analyzed using methods of grounded theory. Five diverse articulations of the relationship between privacy and passive monitoring emerged. The system produced new knowledge about residents and enabled staff to decide how much of that knowledge to disclose to residents. They chose not to disclose to residents their reason for following up on system-generated alerts for 2 reasons: concern that feelings of privacy invasion may arise and cause dissatisfaction with the technology, and the knowledge that many resident users did not comprehend the extent of its features and would be alarmed. This research reveals the importance and challenges of obtaining informed consent. It identifies where boundary intrusion can occur in the use of passive monitoring as well as how changes to technology design and practice could create opportunities for residents to manage their own boundaries according to their privacy needs. The diversity of approaches to privacy supports the need for "opportunity for boundary management" to be employed as both a design and practice principle. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Interactive, technology-enhanced self-regulated learning tools in healthcare education: a literature review.

PubMed

Petty, Julia

2013-01-01

Learning technology is increasingly being implemented for programmes of blended learning within nurse education. With a growing emphasis on self-directed study particularly in post-basic education, there is a need for learners to be guided in their learning away from practice and limited classroom time. Technology-enabled (TE) tools which engage learners actively can play a part in this. The effectiveness and value of interactive TE learning strategies within healthcare is the focus of this paper. To identify literature that explores the effectiveness of interactive, TE tools on knowledge acquisition and learner satisfaction within healthcare with a view to evaluating their use for post-basic nurse education. A Literature Review was performed focusing on papers exploring the comparative value and perceived benefit of TE tools compared to traditional modes of learning within healthcare. The Databases identified as most suitable due to their relevance to healthcare were accessed through EBSCOhost. Primary, Boolean and advanced searches on key terms were undertaken. Inclusion and exclusion criteria were applied which resulted in a final selection of 11 studies for critique. Analysis of the literature found that knowledge acquisition in most cases was enhanced and measured learner satisfaction was generally positive for interactive, self-regulated TE tools. However, TE education may not suit all learners and this is critiqued in the light of the identified limitations. Interactive self regulation and/or testing can be a valuable learning strategy that can be incorporated into self-directed programmes of study for post-registration learners. Whilst acknowledging the learning styles not suited to such tools, the concurrent use of self-directed TE tools with those learning strategies necessitating a more social presence can work together to support enhancement of knowledge required to deliver rationale for nursing practice. Copyright © 2012 Elsevier Ltd. All rights reserved.

Miniaturized Power Processing Unit Study: A Cubesat Electric Propulsion Technology Enabler Project

NASA Technical Reports Server (NTRS)

Ghassemieh, Shakib M.

2014-01-01

This study evaluates High Voltage Power Processing Unit (PPU) technology and driving requirements necessary to enable the Microfluidic Electric Propulsion technology research and development by NASA and university partners. This study provides an overview of the state of the art PPU technology with recommendations for technology demonstration projects and missions for NASA to pursue.

ATOS-1: Designing the infrastructure for an advanced spacecraft operations system

NASA Technical Reports Server (NTRS)

Poulter, K. J.; Smith, H. N.

1993-01-01

The space industry has identified the need to use artificial intelligence and knowledge based system techniques as integrated, central, symbolic processing components of future mission design, support and operations systems. Various practical and commercial constraints require that off-the-shelf applications, and their knowledge bases, are reused where appropriate and that different mission contractors, potentially using different KBS technologies, can provide application and knowledge sub-modules of an overall integrated system. In order to achieve this integration, which we call knowledge sharing and distributed reasoning, there needs to be agreement on knowledge representations, knowledge interchange-formats, knowledge level communications protocols, and ontology. Research indicates that the latter is most important, providing the applications with a common conceptualization of the domain, in our case spacecraft operations, mission design, and planning. Agreement on ontology permits applications that employ different knowledge representations to interwork through mediators which we refer to as knowledge agents. This creates the illusion of a shared model without the constraints, both technical and commercial, that occur in centralized or uniform architectures. This paper explains how these matters are being addressed within the ATOS program at ESOC, using techniques which draw upon ideas and standards emerging from the DARPA Knowledge Sharing Effort. In particular, we explain how the project is developing an electronic Ontology of Spacecraft Operations and how this can be used as an enabling component within space support systems that employ advanced software engineering. We indicate our hope and expectation that the core ontology developed in ATOS, will permit the full development of standards for such systems throughout the space industry.

A Three-fold Outlook of the Ultra-Efficient Engine Technology Program Office (UEET)

NASA Technical Reports Server (NTRS)

Graham, La Quilia E.

2004-01-01

The Ultra-Efficient Engine Technology (UEET) Office at NASA Glenn Research Center is a part of the Aeronautics Directorate. Its vision is to develop and hand off revolutionary turbine engine propulsion technologies that will enable future generation vehicles over a wide range of flight speeds. There are seven different technology area projects of UEET. During my tenure at NASA Glenn Research Center, my assignment was to assist three different areas of UEET, simultaneously. I worked with Kathy Zona in Education Outreach, Lynn Boukalik in Knowledge Management, and Denise Busch with Financial Management. All of my tasks were related to the business side of UEET. As an intern with Education Outreach I created a word search to partner with an exhibit of a Turbine Engine developed out of the UEET office. This exhibit is a portable model that is presented to students of varying ages. The word search complies with National Standards for Education which are part of every science, engineering, and technology teachers curriculum. I also updated a Conference Planning/Workshop Excel Spreadsheet for the UEET Office. I collected and inputted facility overviews from various venues, both on and off site to determine where to hold upcoming conferences. I then documented which facilities were compliant with the Federal Emergency Management Agency's (FEMA) Hotel and Motel Fire Safety Act of 1990. The second area in which I worked was Knowledge Management. a large knowledge management system online which has extensive documentation that continually needs reviewing, updating, and archiving. Knowledge management is the ability to bring individual or team knowledge to an organizational level so that the information can be stored, shared, reviewed, archived. Livelink and a secure server are the Knowledge Management systems that UEET utilizes, Through these systems, I was able to obtain the documents needed for archiving. My assignment was to obtain intellectual property including reports, presentations, or any other documents related to the project. My next task was to document the author, date of creation, and all other properties of each document. To archive these documents I worked extensively with Microsoft Excel. different financial systems of accounting such as the SAP business accounting system. I also learned the best ways to present financial data and shadowed my mentor as she presented financial data to both UEET's project management and the Resources Analysis and Management Office (RAMO). I analyzed the June 2004 financial data of UEET and used Microsoft Excel to input the results of the data. This process made it easier to present the full cost of the project in the month of June. In addition I assisted in the End of the Year 2003 Reconciliation of Purchases of UEET.

The Effect of Field Specialization Variation on Technological Pedagogical Content Knowledge (TPACK) among Malaysian TVET Instructors

ERIC Educational Resources Information Center

Chua, Junnaina Husin; Jamil, Hazri

2014-01-01

Technological Knowledge is directly related to productivity, enhanced performance and service quality. Technology integration in the Technical and Vocational Education and Training (TVET) curriculum is expected due to high application of technical knowledge and technology applications. TPACK is a professional knowledge framework that gives…

Approaches to emergency management teaching at the master's level.

PubMed

Alexander, David

2013-01-01

Training and education enable emergency managers to deal with complex situations, create durable networks of people with appropriate expertise, and ensure that knowledge is utilized to improve resilience in the face of disaster risk. Although there is a discrete literature on emergency management training, few attempts have been made to create an overview that discusses the key issues and proposes a standardized approach. This article examines the nature of training and education in emergency and disaster management. It analyzes the composition and requirements of courses at the master's degree level, which is considered to be the most appropriate tier for in-depth instruction in this field. This article defines "training" and "education" in the context of emergency management courses. It reviews the developing profile of the emergency manager in the light of training requirements. This article examines the question of whether emergency management is a branch of management science or whether it is something distinct and separate. Attention is given to the composition of a core curriculum and to the most appropriate pedagogical forms of delivering it. The article reviews the arguments for and against standardization of the curriculum and describes some of the pedagogical methods for delivering courses. Briefly, it considers the impact on training and education of new pedagogic methods based on information technology. It is concluded that the master's level is particularly suited to emergency and crisis management education, as it enables students to complement the in-depth knowledge they acquired in their disciplinary first degrees with a broader synthetic approach at the postgraduate level. Some measures of standardization of course offerings are desirable, in favor of creating a core curriculum that will ensure that essential core knowledge is imparted. Education and training in this field should include problem-solving approaches that enable students to learn practical skills as well as theory.

Implementing a Social Knowledge Networking (SKN) system to enable meaningful use of an EHR medication reconciliation system.

PubMed

Rangachari, Pavani

2018-01-01

Despite the regulatory impetus toward meaningful use of electronic health record (EHR) Medication Reconciliation (MedRec) to prevent medication errors during care transitions, hospital adherence has lagged for one chief reason: low physician engagement, stemming from lack of consensus about which physician is responsible for managing a patient's medication list. In October 2016, Augusta University received a 2-year grant from the Agency for Healthcare Research and Quality to implement a Social Knowledge Networking (SKN) system for enabling its health system (AU Health) to progress from "limited use" of EHR MedRec technology to "meaningful use." The hypothesis is that SKN would bring together a diverse group of practitioners, to facilitate tacit knowledge exchange on issues related to EHR MedRec, which in turn is expected to increase practitioners' engagement in addressing those issues and enable meaningful use of EHR. The specific aims are to examine: 1) user-engagement in the SKN system, and 2) associations between "SKN use" and "meaningful use" of EHR. The 2-year project uses an exploratory mixed-method design and consists of three phases: 1) development; 2) SKN implementation; and 3) analysis. Phase 1, completed in May 2017, sought to identify a comprehensive set of issues related to EHR MedRec from practitioners directly involved in the MedRec process. This process facilitated development of a "Reporting Tool" on issues related to EHR MedRec, which, along with an existing "SKN/Discussion Tool," was integrated into the EHR at AU Health. Phase 2 (launched in June 2017) involves implementing the EHR-integrated SKN system over a 52-week period in inpatient and outpatient medicine units. The prospective implementation design is expected to generate context-sensitive strategies for meaningful use and successful implementation of EHR MedRec and thereby make substantial contributions to the patient safety and risk management literature. From a health care policy perspective, if the hypothesis holds, federal vendors could be encouraged to incorporate SKN features into EHR systems.

Nursing constraint models for electronic health records: a vision for domain knowledge governance.

PubMed

Hovenga, Evelyn; Garde, Sebastian; Heard, Sam

2005-12-01

Various forms of electronic health records (EHRs) are currently being introduced in several countries. Nurses are primary stakeholders and need to ensure that their information and knowledge needs are being met by such systems information sharing between health care providers to enable them to improve the quality and efficiency of health care service delivery for all subjects of care. The latest international EHR standards have adopted the openEHR approach of two-level modelling. The first level is a stable information model determining structure, while the second level consists of constraint models or 'archetypes' that reflect the specifications or clinician rules for how clinical information needs to be represented to enable unambiguous data sharing. The current state of play in terms of international health informatics standards development activities is providing the nursing profession with a unique opportunity and challenge. Much work has been undertaken internationally in the area of nursing terminologies and evidence-based practice. This paper argues that to make the most of these emerging technologies and EHRs we must now concentrate on developing a process to identify, document, implement, manage and govern our nursing domain knowledge as well as contribute to the development of relevant international standards. It is argued that one comprehensive nursing terminology, such as the ICNP or SNOMED CT is simply too complex and too difficult to maintain. As the openEHR archetype approach does not rely heavily on big standardised terminologies, it offers more flexibility during standardisation of clinical concepts and it ensures open, future-proof electronic health records. We conclude that it is highly desirable for the nursing profession to adopt this openEHR approach as a means of documenting and governing the nursing profession's domain knowledge. It is essential for the nursing profession to develop its domain knowledge constraint models (archetypes) collaboratively in an international context.

Analysing Teacher Knowledge for Technology Education in Primary Schools

ERIC Educational Resources Information Center

Rohaan, Ellen J.; Taconis, Ruurd; Jochems, Wim M. G.

2012-01-01

Teacher knowledge guides a teacher's behaviour in the classroom. Teacher knowledge for technology education is generally assumed to play an important role in affecting pupils' learning in technology. There are an abundant number of teacher knowledge models that visualise different domains of teacher knowledge, but clear empirical evidence on how…

A Knowledge-Based System For Analysis, Intervention Planning and Prevention of Defects in Immovable Cultural Heritage Objects and Monuments

NASA Astrophysics Data System (ADS)

Valach, J.; Cacciotti, R.; Kuneš, P.; ČerÅanský, M.; Bláha, J.

2012-04-01

The paper presents a project aiming to develop a knowledge-based system for documentation and analysis of defects of cultural heritage objects and monuments. The MONDIS information system concentrates knowledge on damage of immovable structures due to various causes, and preventive/remedial actions performed to protect/repair them, where possible. The currently built system is to provide for understanding of causal relationships between a defect, materials, external load, and environment of built object. Foundation for the knowledge-based system will be the systemized and formalized knowledge on defects and their mitigation acquired in the process of analysis of a representative set of cases documented in the past. On the basis of design comparability, used technologies, materials and the nature of the external forces and surroundings, the developed software system has the capacity to indicate the most likely risks of new defect occurrence or the extension of the existing ones. The system will also allow for a comparison of the actual failure with similar cases documented and will propose a suitable technical intervention plan. The system will provide conservationists, administrators and owners of historical objects with a toolkit for defect documentation for their objects. Also, advanced artificial intelligence methods will offer accumulated knowledge to users and will also enable them to get oriented in relevant techniques of preventive interventions and reconstructions based on similarity with their case.

Adapting Technological Pedagogical Content Knowledge Framework to Teach Mathematics

ERIC Educational Resources Information Center

Getenet, Seyum Tekeher

2017-01-01

The technological pedagogical content knowledge framework is increasingly in use by educational technology researcher as a generic description of the knowledge requirements for teachers using technology in all subjects. This study describes the development of a mathematics specific variety of the technological pedagogical content knowledge…

A Recipe for Streamlining Mission Management

NASA Technical Reports Server (NTRS)

Mitchell, Andrew E.; Semancik, Susan K.

2004-01-01

This paper describes a project's design and implementation for streamlining mission management with knowledge capture processes across multiple organizations of a NASA directorate. Thc project's focus is on standardizing processes and reports; enabling secure information access and case of maintenance; automating and tracking appropriate workflow rules through process mapping; and infusing new technologies. This paper will describe a small team's experiences using XML technologies through an enhanced vendor suite of applications integrated on Windows-based platforms called the Wallops Integrated Scheduling and Document Management System (WISDMS). This paper describes our results using this system in a variety of endeavors, including providing range project scheduling and resource management for a Range and Mission Management Office; implementing an automated Customer Feedback system for a directorate; streamlining mission status reporting across a directorate; and initiating a document management, configuration management and portal access system for a Range Safety Office's programs. The end result is a reduction of the knowledge gap through better integration and distribution of information, improved process performance, automated metric gathering, and quicker identification of problem areas and issues. However, the real proof of the pudding comes through overcoming the user's reluctance to replace familiar, seasoned processes with new technology ingredients blended with automated procedures in an untested recipe. This paper shares some of the team's observations that led to better implementation techniques, as well as an IS0 9001 Best Practices citation. This project has provided a unique opportunity to advance NASA's competency in new technologies, as well as to strategically implement them within an organizational structure, while wetting the appetite for continued improvements in mission management.

Applying systems engineering methodologies to the micro- and nanoscale realm

NASA Astrophysics Data System (ADS)

Garrison Darrin, M. Ann

2012-06-01

Micro scale and nano scale technology developments have the potential to revolutionize smart and small systems. The application of systems engineering methodologies that integrate standalone, small-scale technologies and interface them with macro technologies to build useful systems is critical to realizing the potential of these technologies. This paper covers the expanding knowledge base on systems engineering principles for micro and nano technology integration starting with a discussion of the drivers for applying a systems approach. Technology development on the micro and nano scale has transition from laboratory curiosity to the realization of products in the health, automotive, aerospace, communication, and numerous other arenas. This paper focuses on the maturity (or lack thereof) of the field of nanosystems which is emerging in a third generation having transitioned from completing active structures to creating systems. The emphasis of applying a systems approach focuses on successful technology development based on the lack of maturity of current nano scale systems. Therefore the discussion includes details relating to enabling roles such as product systems engineering and technology development. Classical roles such as acquisition systems engineering are not covered. The results are also targeted towards small-scale technology developers who need to take into account systems engineering processes such as requirements definition, verification, and validation interface management and risk management in the concept phase of technology development to maximize the likelihood of success, cost effective micro and nano technology to increase the capability of emerging deployed systems and long-term growth and profits.

WikiGenomes: an open web application for community consumption and curation of gene annotation data in Wikidata

DOE Office of Scientific and Technical Information (OSTI.GOV)

Putman, Tim E.; Lelong, Sebastien; Burgstaller-Muehlbacher, Sebastian

With the advancement of genome-sequencing technologies, new genomes are being sequenced daily. Although these sequences are deposited in publicly available data warehouses, their functional and genomic annotations (beyond genes which are predicted automatically) mostly reside in the text of primary publications. Professional curators are hard at work extracting those annotations from the literature for the most studied organisms and depositing them in structured databases. However, the resources don’t exist to fund the comprehensive curation of the thousands of newly sequenced organisms in this manner. Here, we describe WikiGenomes (wikigenomes.org), a web application that facilitates the consumption and curation of genomicmore » data by the entire scientific community. WikiGenomes is based on Wikidata, an openly editable knowledge graph with the goal of aggregating published knowledge into a free and open database. WikiGenomes empowers the individual genomic researcher to contribute their expertise to the curation effort and integrates the knowledge into Wikidata, enabling it to be accessed by anyone without restriction.« less

Place and culture-based professional development: cross-hybrid learning and the construction of ecological mindfulness

NASA Astrophysics Data System (ADS)

Chinn, Pauline W. U.

2015-03-01

This paper approaches mindfulness, an awareness of internal and external realities, as a culturally-shaped habit of mind. Findings of a cross-cultural study and popular sayings that reflect America's cultural orientation to consumption and competition are contrasted with findings from Hawaiian language newspapers, traditional cultural practices, and Hawaiian sayings that indicate an orientation to ecological mindfulness that increased the resilience of fragile social ecosystems. Marginalization of indigenous culture, language, and knowledge and cultural differences between teachers and indigenous students are proposed as a contributing factor to lower science performance of Native Hawaiian students in mainstream schools. Two professional development projects designed to reduce conflicts between culture and science instruction are presented. Findings from these projects suggest alignment of science inquiry with indigenous cultural knowledge and practices oriented to sustainability supports the development of teachers' ecological mindfulness as indicated by increased awareness of, interest in, and incorporation of place and culture-based based resources into their instruction. Teacher feedback indicates that mapping technologies that enable teachers to visualize and integrate indigenous place-based Hawaiian knowledge with science inquiry are promising instructional strategies.

R&D in Poland: Is the Country Close to a Knowledge-Driven Economy?

NASA Astrophysics Data System (ADS)

Chybowska, Dorota; Chybowski, Leszek; Souchkov, Valeri

2018-06-01

Poland has a strong ambition to evolve rapidly into a knowledge-driven economy. Since 2004, it has been the largest beneficiary of European Union cohesion policy funds among all member states. Between 2007 and 2013, Poland was allocated approximately EUR 67 billion, whereas for 2014-2020 the EU budget earmarked EUR 82.5 billion for Polish cohesion policy. This means that in the coming years, Poland's R&D intensity will grow. But the question remains: is 27 years of free market economy enough to enable a country's economy to become knowledge-based ? This paper offers an analysis of Polish R&D expenditures and investments in terms of their sources (business, government or higher education sectors), types (European Union or state aid) and areas of support (infrastructure, education or innovation). It also characterises the Polish R&D market with its strengths and weaknesses. Then, it examines the process of technology transfer in Poland, comparing it to best practice. Finally, the paper lays out the barriers to effective commercialisation that need to be overcome, and attempts to answer the question raised in its title.

WikiGenomes: an open web application for community consumption and curation of gene annotation data in Wikidata

DOE PAGES

Putman, Tim E.; Lelong, Sebastien; Burgstaller-Muehlbacher, Sebastian; ...

2017-03-06

With the advancement of genome-sequencing technologies, new genomes are being sequenced daily. Although these sequences are deposited in publicly available data warehouses, their functional and genomic annotations (beyond genes which are predicted automatically) mostly reside in the text of primary publications. Professional curators are hard at work extracting those annotations from the literature for the most studied organisms and depositing them in structured databases. However, the resources don’t exist to fund the comprehensive curation of the thousands of newly sequenced organisms in this manner. Here, we describe WikiGenomes (wikigenomes.org), a web application that facilitates the consumption and curation of genomicmore » data by the entire scientific community. WikiGenomes is based on Wikidata, an openly editable knowledge graph with the goal of aggregating published knowledge into a free and open database. WikiGenomes empowers the individual genomic researcher to contribute their expertise to the curation effort and integrates the knowledge into Wikidata, enabling it to be accessed by anyone without restriction.« less

Electronic health records (EHRs): supporting ASCO's vision of cancer care.

PubMed

Yu, Peter; Artz, David; Warner, Jeremy

2014-01-01

ASCO's vision for cancer care in 2030 is built on the expanding importance of panomics and big data, and envisions enabling better health for patients with cancer by the rapid transformation of systems biology knowledge into cancer care advances. This vision will be heavily dependent on the use of health information technology for computational biology and clinical decision support systems (CDSS). Computational biology will allow us to construct models of cancer biology that encompass the complexity of cancer panomics data and provide us with better understanding of the mechanisms governing cancer behavior. The Agency for Healthcare Research and Quality promotes CDSS based on clinical practice guidelines, which are knowledge bases that grow too slowly to match the rate of panomic-derived knowledge. CDSS that are based on systems biology models will be more easily adaptable to rapid advancements and translational medicine. We describe the characteristics of health data representation, a model for representing molecular data that supports data extraction and use for panomic-based clinical research, and argue for CDSS that are based on systems biology and are algorithm-based.

A knowledge-based system design/information tool

NASA Technical Reports Server (NTRS)

Allen, James G.; Sikora, Scott E.

1990-01-01

The objective of this effort was to develop a Knowledge Capture System (KCS) for the Integrated Test Facility (ITF) at the Dryden Flight Research Facility (DFRF). The DFRF is a NASA Ames Research Center (ARC) facility. This system was used to capture the design and implementation information for NASA's high angle-of-attack research vehicle (HARV), a modified F/A-18A. In particular, the KCS was used to capture specific characteristics of the design of the HARV fly-by-wire (FBW) flight control system (FCS). The KCS utilizes artificial intelligence (AI) knowledge-based system (KBS) technology. The KCS enables the user to capture the following characteristics of automated systems: the system design; the hardware (H/W) design and implementation; the software (S/W) design and implementation; and the utilities (electrical and hydraulic) design and implementation. A generic version of the KCS was developed which can be used to capture the design information for any automated system. The deliverable items for this project consist of the prototype generic KCS and an application, which captures selected design characteristics of the HARV FCS.

Ever-present threats from information technology: the Cyber-Paranoia and Fear Scale

PubMed Central

Mason, Oliver J.; Stevenson, Caroline; Freedman, Fleur

2014-01-01

Delusions involving technology, and specifically the internet, are increasingly common, and fear-reality statistics suggest computer-related fears are very widespread. These fears form a continuum from the widely understandable and realistic to the unrealistic, and frankly paranoid. The present study investigated the validity of this construct in a non-clinical population by constructing a novel self-report measure. The new Cyber-Paranoia and Fear Scale aims to measure the perception of information technology-related threats originating from or enabled by computers, smartphones, social networks, and digital surveillance. Psychometric properties of the new Cyber-Paranoia and Fear Scale are reported alongside an established measure of suspiciousness and paranoia in 181 participants including a sub-group of fifty information technology professionals. Exploratory factor analysis suggested the presence of two, related, dimensions that we term cyber-paranoia and cyber-fear. Both sub-scales were internally consistent and produced a normal distribution of scores. The relationships of the sub-scales with age, gender, trait paranoia, digital literacy, and digital inclusion are supportive of construct validity. The distinctiveness of ‘cyber-paranoia’ from general trait paranoia appears to mirror the clinical distinctiveness of ‘internet’ and other technology-fuelled delusions. Knowledge provision to increase technological proficiency and awareness may bring about a reduction in cyber-paranoia. PMID:25505431

Ever-present threats from information technology: the Cyber-Paranoia and Fear Scale.

PubMed

Mason, Oliver J; Stevenson, Caroline; Freedman, Fleur

2014-01-01

Delusions involving technology, and specifically the internet, are increasingly common, and fear-reality statistics suggest computer-related fears are very widespread. These fears form a continuum from the widely understandable and realistic to the unrealistic, and frankly paranoid. The present study investigated the validity of this construct in a non-clinical population by constructing a novel self-report measure. The new Cyber-Paranoia and Fear Scale aims to measure the perception of information technology-related threats originating from or enabled by computers, smartphones, social networks, and digital surveillance. Psychometric properties of the new Cyber-Paranoia and Fear Scale are reported alongside an established measure of suspiciousness and paranoia in 181 participants including a sub-group of fifty information technology professionals. Exploratory factor analysis suggested the presence of two, related, dimensions that we term cyber-paranoia and cyber-fear. Both sub-scales were internally consistent and produced a normal distribution of scores. The relationships of the sub-scales with age, gender, trait paranoia, digital literacy, and digital inclusion are supportive of construct validity. The distinctiveness of 'cyber-paranoia' from general trait paranoia appears to mirror the clinical distinctiveness of 'internet' and other technology-fuelled delusions. Knowledge provision to increase technological proficiency and awareness may bring about a reduction in cyber-paranoia.

Assisted-living spaces for end-users with complex needs: a proposed implementation and delivery model.

PubMed

Linskell, Jeremy; Bouamrane, Matt-Mouley

2012-09-01

An assisted living space (ALS) is a technology-enabled environment designed to allow people with complex health or social care needs to remain, and live independently, in their own home for longer. However, many challenges remain in order to deliver usable systems acceptable to a diverse range of stakeholders, including end-users, and their families and carers, as well as health and social care services. ALSs need to support activities of daily-living while allowing end-users to maintain important social connections. They must be dynamic, flexible and adaptable living environments. In this article, we provide an overview of the technological landscape of assisted-living technology (ALT) and recent policies to promote an increased adoption of ALT in Scotland. We discuss our experiences in implementing technology-supported ALSs and emphasise key lessons. Finally, we propose an iterative and pragmatic user-centred implementation model for delivering ALSs in complex-needs scenarios. This empirical model is derived from our past ALS implementations. The proposed model allows project stakeholders to identify requirements, allocate tasks and responsibilities, and identify appropriate technological solutions for the delivery of functional ALS systems. The model is generic and makes no assumptions on needs or technology solutions, nor on the technical knowledge, skills and experience of the stakeholders involved in the ALS design process.

Enabling Metacognitive Skills for Mathematics Problem Solving: A Collective Case Study of Metacognitive Reflection and Awareness

ERIC Educational Resources Information Center

Jagals, Divan; van der Walt, Marthie

2016-01-01

Metacognition encompasses knowledge and regulation that, through reflection, sustain problem solving behaviour. How metacognitive awareness is constructed from reflection on metacognitive knowledge and regulation and how these reflections enable metacognitive skills for Mathematics problem solving remain unclear. Three secondary schools…

Developing Accessible Cyberinfrastructure-Enabled Knowledge Communities in the National Disability Community: Theory, Practice, and Policy

ERIC Educational Resources Information Center

Myhill, William N.; Cogburn, Derrick L.; Samant, Deepti

2008-01-01

Since publication of the Atkins Commission report 2003, the national scientific community has placed significant emphasis on developing cyberinfrastructure-enabled knowledge communities, which are designed to facilitate enhanced efficiency and collaboration in geographically distributed networks of researchers. This article suggests that the new…

FY08 Engineering Research and Technology Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minichino, C; McNichols, D

2009-02-24

This report summarizes the core research, development, and technology accomplishments in Lawrence Livermore National Laboratory's Engineering Directorate for FY2008. These efforts exemplify Engineering's more than 50-year history of developing and applying the technologies needed to support the Laboratory's national security missions. A partner in every major program and project at the Laboratory throughout its existence, Engineering has prepared for this role with a skilled workforce and technical resources developed through both internal and external venues. These accomplishments embody Engineering's mission: 'Enable program success today and ensure the Laboratory's vitality tomorrow.' Engineering's mission is carried out through basic research and technologymore » development. Research is the vehicle for creating competencies that are cutting-edge, or require discovery-class groundwork to be fully understood. Our technology efforts are discipline-oriented, preparing research breakthroughs for broader application to a variety of Laboratory needs. The term commonly used for technology-based projects is 'reduction to practice.' As we pursue this two-pronged approach, an enormous range of technological capabilities result. This report combines our work in research and technology into one volume, organized into thematic technical areas: Engineering Modeling and Simulation; Measurement Technologies; Micro/Nano-Devices and Structures; Engineering Systems for Knowledge and Inference; and Energy Manipulation. Our investments in these areas serve not only known programmatic requirements of today and tomorrow, but also anticipate the breakthrough engineering innovations that will be needed in the future.« less

Audacious goals for health and biomedical informatics in the new millennium.

PubMed

Greenes, R A; Lorenzi, N M

1998-01-01

The 1998 Scientific Symposium of the American College of Medical Informatics (ACMI) was devoted to developing visions for the future of health care and biomedicine and a strategic agenda for health and biomedical informatics in support of those visions. This symposium focus was prompted by the many major changes currently underway in health care delivery, education, and research, as well as in our health and biomedical enterprises, and by the constantly increasing role of information technology in both shaping and enabling these changes. The three audacious goals developed for 2008 are a virtual health care databank, a national health care knowledge base, and a personal clinical health record.

Methodology of shooting training using modern IT techniques

NASA Astrophysics Data System (ADS)

Gudzbeler, Grzegorz; Struniawski, Jarosław

2017-08-01

Mastering, improvement, shaping and preservation of skills of safe, efficient and effective use of the firearm requires the use of relevant methodology of conducting the shooting training. However reality of police trainings does not usually allow for intensive training shooting with the use of ammunition. An alternative solution is the use of modern training technologies. Example of this is the "Virtual system of improvement tactics of intervention services responsible for security and shooting training." Introduction of stimulator to police trainings will enable complete stuff preparation to achieve its tasks, creating potential of knowledge and experience in many areas, far exceeding the capabilities of conventional training.

Natural language modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharp, J.K.

1997-11-01

This seminar describes a process and methodology that uses structured natural language to enable the construction of precise information requirements directly from users, experts, and managers. The main focus of this natural language approach is to create the precise information requirements and to do it in such a way that the business and technical experts are fully accountable for the results. These requirements can then be implemented using appropriate tools and technology. This requirement set is also a universal learning tool because it has all of the knowledge that is needed to understand a particular process (e.g., expense vouchers, projectmore » management, budget reviews, tax, laws, machine function).« less

Far-field mission planning for nap-of-the-earth flight

NASA Technical Reports Server (NTRS)

Deutsch, Owen L.; Desai, Mukund; Mcgee, Leonard A.

1987-01-01

In the face of numerically superior hostile forces, deployment of individual vehicles to the right place, at the right time, and the ability to plan missions with less conservatism, will become significant force multipliers. Far-field mission planning is one of the enabling technologies that will facilitate force coordination through management of mission timeline, vehicle survivability and fuel constraints. On-board replanning is required to deal responsively with departures from nominal plan execution that result from imperfect knowledge of and temporal variability in the mission environment. The far-field planning problem is posed as a constrained optimization problem and algorithms and structural organization are proposed for the solution.

Big data, miniregistries: a rapid-turnaround solution to get quality improvement data into the hands of medical specialists.

PubMed

Herrinton, Lisa J; Liu, Liyan; Altschuler, Andrea; Dell, Richard; Rabrenovich, Violeta; Compton-Phillips, Amy L

2015-01-01

The cost to build and to maintain traditional registries for many dire, complex, low-frequency conditions is prohibitive. The authors used accessible technology to develop a platform that would generate miniregistries (small, routinely updated datasets) for surveillance, to identify patients who were missing elected utilization and to influence clinicians to change practices to improve care. The platform, tested in 5 medical specialty departments, enabled the specialists to rapidly and effectively communicate clinical questions, knowledge of disease, clinical workflows, and improve opportunities. Each miniregistry required 1 to 2 hours of collaboration by a specialist. Turnaround was 1 to 14 days.

Bioinformatics for Exploration

NASA Technical Reports Server (NTRS)

Johnson, Kathy A.

2006-01-01

For the purpose of this paper, bioinformatics is defined as the application of computer technology to the management of biological information. It can be thought of as the science of developing computer databases and algorithms to facilitate and expedite biological research. This is a crosscutting capability that supports nearly all human health areas ranging from computational modeling, to pharmacodynamics research projects, to decision support systems within autonomous medical care. Bioinformatics serves to increase the efficiency and effectiveness of the life sciences research program. It provides data, information, and knowledge capture which further supports management of the bioastronautics research roadmap - identifying gaps that still remain and enabling the determination of which risks have been addressed.

Nanoethics, Science Communication, and a Fourth Model for Public Engagement.

PubMed

Miah, Andy

2017-01-01

This paper develops a fourth model of public engagement with science, grounded in the principle of nurturing scientific agency through participatory bioethics. It argues that social media is an effective device through which to enable such engagement, as it has the capacity to empower users and transforms audiences into co-producers of knowledge, rather than consumers of content. Social media also fosters greater engagement with the political and legal implications of science, thus promoting the value of scientific citizenship. This argument is explored by considering the case of nanoscience and nanotechnology, as an exemplar for how emerging technologies may be handled by the scientific community and science policymakers.

Marshall Space Flight Center Propulsion Systems Department (PSD) Knowledge Management (KM) Initiative

NASA Technical Reports Server (NTRS)

Caraccioli, Paul; Varnedoe, Tom; Smith, Randy; McCarter, Mike; Wilson, Barry; Porter, Richard

2006-01-01

NASA Marshall Space Flight Center's Propulsion Systems Department (PSD) is four months into a fifteen month Knowledge Management (KM) initiative to support enhanced engineering decision making and analyses, faster resolution of anomalies (near-term) and effective, efficient knowledge infused engineering processes, reduced knowledge attrition, and reduced anomaly occurrences (long-term). The near-term objective of this initiative is developing a KM Pilot project, within the context of a 3-5 year KM strategy, to introduce and evaluate the use of KM within PSD. An internal NASA/MSFC PSD KM team was established early in project formulation to maintain a practitioner, user-centric focus throughout the conceptual development, planning and deployment of KM technologies and capabilities within the PSD. The PSD internal team is supported by the University of Alabama's Aging Infrastructure Systems Center of Excellence (AISCE), lntergraph Corporation, and The Knowledge Institute. The principle product of the initial four month effort has been strategic planning of PSD KNI implementation by first determining the "as is" state of KM capabilities and developing, planning and documenting the roadmap to achieve the desired "to be" state. Activities undertaken to suppoth e planning phase have included data gathering; cultural surveys, group work-sessions, interviews, documentation review, and independent research. Assessments and analyses have beon pedormed including industry benchmarking, related local and Agency initiatives, specific tools and techniques used and strategies for leveraging existing resources, people and technology to achieve common KM goals. Key findings captured in the PSD KM Strategic Plan include the system vision, purpose, stakeholders, prioritized strategic objectives mapped to the top ten practitioner needs and analysis of current resource usage. Opportunities identified from research, analyses, cultural1KM surveys and practitioner interviews include: executive and senior management sponsorship, KM awareness, promotion and training, cultural change management, process improvement, leveraging existing resources and new innovative technologies to align with other NASA KM initiatives (convergence: the big picture). To enable results based incremental implementation and future growth of the KM initiative, key performance measures have been identified including stakeholder value, system utility, learning and growth (knowledge capture, sharing, reduced anomaly recurrence), cultural change, process improvement and return-on-investment. The next steps for the initial implementation spiral (focused on SSME Turbomachinery) have been identified, largely based on the organization and compilation of summary level engineering process models, data capture matrices, functional models and conceptual-level svstems architecture. Key elements include detailed KM requirements definition, KM technology architecture assessment, - evaluation and selection, deployable KM Pilot design, development, implementation and evaluation, and justifying full implementation (estimated Return-on-Investment). Features identified for the notional system architecture include the knowledge presentation layer (and its components), knowledge network layer (and its components), knowledge storage layer (and its components), User Interface and capabilities. This paper provides a snapshot of the progress to date, the near term planning for deploying the KM pilot project and a forward look at results based growth of KM capabilities with-in the MSFC PSD.

An Investigation of Technological Pedagogical Content Knowledge, Self-Confidence, and Perception of Pre-Service Middle School Mathematics Teachers towards Instructional Technologies

ERIC Educational Resources Information Center

Karatas, Ilhan; Tunc, Mutlu Piskin; Yilmaz, Nurbanu; Karaci, Gulzade

2017-01-01

Technology provides new methods and approaches for educational activities. Therefore, teachers should improve their ability and knowledge to integrate technology into instruction. The use of technology-based learning environment which is effectively used to improve the technological pedagogical content knowledge of pre-service teachers has a…

The investigation of science teachers’ experience in integrating digital technology into science teaching

NASA Astrophysics Data System (ADS)

Agustin, R. R.; Liliasari; Sinaga, P.; Rochintaniawati, D.

2018-05-01

The use of technology into science learning encounters problems. One of the problem is teachers’ less technological pedagogical and content knowledge (TPACK) on the implementation of technology itself. The purpose of this study was to investigate science teachers’ experience in using digital technology into science classroom. Through this study science teachers’ technological knowledge (TK) and technological content knowledge (TCK) can be unpacked. Descriptive method was used to depict science teachers’ TK and TCK through questionnaire that consisted of 20 questions. Subjects of this study were 25 science teachers in Bandung, Indonesia. The study was conducted in the context of teacher professional training. Result shows that science teachers still have less TK, yet they have high TCK. The teachers consider characteristics of concepts as main aspect for implementing technology into science teaching. This finding describes teachers’ high technological content knowledge. Meanwhile, science teachers’ technological knowledge was found to be still low since only few of them who can exemplify digital technology that can be implemented into several science concept. Therefore, training about technology implementation into science teaching and learning is necessary as a means to improve teachers’ technological knowledge.

Issues of Learning and Knowledge in Technology Education

ERIC Educational Resources Information Center

McCormick, Robert

2004-01-01

This article examines issues that arise from learning and knowledge in technology education. The issues examined are, first, the definition of technological knowledge and what the nature of that knowledge should be, where the concern is with "how" we define and think about that knowledge, especially in the context of how students learn and use…

Non-Linear Effects in Knowledge Production

NASA Astrophysics Data System (ADS)

Purica, Ionut

2007-04-01

The generation of technological knowledge is paramount to our present development; the production of technological knowledge is governed by the same Cobb Douglas type model, with the means of research and the intelligence level replacing capital, respectively labor. We are exploring the basic behavior of present days' economies that are producing technological knowledge, along with the `usual' industrial production and determine a basic behavior that turns out to be a `Henon attractor'. Measures are introduced for the gain of technological knowledge and for the information of technological sequences that are based respectively on the underlying multi-valued modal logic of the technological research and on nonlinear thermodynamic considerations.

Tele-surgery: a new virtual tool for medical education.

PubMed

Russomano, Thais; Cardoso, Ricardo B; Fernandes, Jefferson; Cardoso, Paulizan G; Alves, Jarcedy M; Pianta, Christina D; Souza, Hamilton P; Lopes, Maria Helena I

2009-01-01

The rapid evolution of telecommunication technology has enabled advances to be made in low cost video-conferencing through the improvement of high speed computer communication networks and the enhancement of Internet security protocols. As a result of this progress, eHealth education programs are becoming a reality in universities, providing the opportunity for students to have greater interaction at live surgery classes by means of virtual participation. Undergraduate students can be introduced to new concepts of medical care, remote second opinion and to telecommunication systems, whilst virtually experiencing surgical procedures and lectures. The better access this provides to the operating theater environment, the patient and the surgeon can improve the learning process for students. An analogical system was used for this experimental pilot project due to the benefits of it being low cost with a comparatively easy setup. The tele-surgery lectures were also transmitted to other universities by means of a Pentium 4 computer using open source software and connected to a portable image acquisition device located in the São Lucas University Hospital. Telemedicine technology has proven to be an important instrument for the improvement of medical education and health care. This study allowed health professionals, professors and students to have greater interaction during surgical procedures, thus enabling a greater opportunity for knowledge exchange.

An information technology infrastructure to enable evidence-based nursing practice.

PubMed

Pochciol, Joan M; Warren, Joan I

2009-01-01

The movement toward evidence-based practice (EBP) poses new organizational challenges to provide the necessary infrastructure to promote effective nursing interventions based on the best available evidence. The purpose of this article is to describe a collaborative effort between nursing and library services to provide readily accessible information at the bedside to support nurses using the best available evidence. In collaboration with nursing, the Health Services Librarian created an information resource titled "Research-based Nursing Practice: Finding the Evidence," which enables nursing staff to access the resources at the bedside without having to perform lengthy searches. Every known resource that will educate nurses in defining EBP to providing them with the links to Web sites, published articles, and all the information resources is included in the tool. Much has been written about building the organizational infrastructure to promote EBP and finding the filtered, synthesized research evidence, but to our knowledge, little has been published on building the information technology infrastructure, which will give nurses real-time access at the point-of-care to the research evidence. The research-based nursing practice system is helping bridge the gap between evidence-based resources and practice by compiling the literature in one place and making it easily and readily accessible.

Sustainable knowledge development across cultural boundaries: Experiences from the EU-project SILMAS (Toolbox for conflict solving instruments in Alpine Lake Management)

NASA Astrophysics Data System (ADS)

Fegerl, Michael; Wieden, Wilfried

2013-04-01

Increasingly people have to communicate knowledge across cultural and language boundaries. Even though recent technologies offer powerful communication facilities people often feel confronted with barriers which clearly reduce their chances of making their interaction a success. Concrete evidence concerning such problems derives from a number of projects, where generated knowledge often results in dead-end products. In the Alpine Space-project SILMAS (Sustainable Instruments for Lake Management in Alpine Space), in which both authors were involved, a special approach (syneris® ) was taken to avoid this problem and to manage project knowledge in sustainable form. Under this approach knowledge input and output are handled interactively: Relevant knowledge can be developed continuously and users can always access the latest state of expertise. Resort to the respective tools and procedures can also assist in closing knowledge gaps and in developing innovative responses to familiar or novel problems. This contribution intends to describe possible ways and means which have been found to increase the chances of success of knowledge communication across cultural boundaries. The process of trans-cultural discussions of experts to find a standardized solution is highlighted as well as the problem of dissemination of expert knowledge to variant stakeholders. Finally lessons learned are made accessible, where a main task lies in the creation of a tool box for conflict solving instruments, as a demonstrable result of the project and for the time thereafter. The interactive web-based toolbox enables lake managers to access best practice instruments in standardized, explicit and cross-linguistic form.