Circulation control propellers for general aviation, including a BASIC computer program

NASA Technical Reports Server (NTRS)

Taback, I.; Braslow, A. L.; Butterfield, A. J.

1983-01-01

The feasibility of replacing variable pitch propeller mechanisms with circulation control (Coanada effect) propellers on general aviation airplanes was examined. The study used a specially developed computer program written in BASIC which could compare the aerodynamic performance of circulation control propellers with conventional propellers. The comparison of aerodynamic performance for circulation control, fixed pitch and variable pitch propellers is based upon the requirements for a 1600 kg (3600 lb) single engine general aviation aircraft. A circulation control propeller using a supercritical airfoil was shown feasible over a representative range of design conditions. At a design condition for high speed cruise, all three types of propellers showed approximately the same performance. At low speed, the performance of the circulation control propeller exceeded the performance for a fixed pitch propeller, but did not match the performance available from a variable pitch propeller. It appears feasible to consider circulation control propellers for single engine aircraft or multiengine aircraft which have their propellers on a common axis (tractor pusher). The economics of the replacement requires a study for each specific airplane application.

Correlations between the modelled potato crop yield and the general atmospheric circulation

NASA Astrophysics Data System (ADS)

Sepp, Mait; Saue, Triin

2012-07-01

Biology-related indicators do not usually depend on just one meteorological element but on a combination of several weather indicators. One way to establish such integral indicators is to classify the general atmospheric circulation into a small number of circulation types. The aim of present study is to analyse connections between general atmospheric circulation and potato crop yield in Estonia. Meteorologically possible yield (MPY), calculated by the model POMOD, is used to characterise potato crop yield. Data of three meteorological stations and the biological parameters of two potato sorts were applied to the model, and 73 different classifications of atmospheric circulation from catalogue 1.2 of COST 733, domain 05 are used to qualify circulation conditions. Correlation analysis showed that there is at least one circulation type in each of the classifications with at least one statistically significant (99%) correlation with potato crop yield, whether in Kuressaare, Tallinn or Tartu. However, no classifications with circulation types correlating with MPY in all three stations at the same time were revealed. Circulation types inducing a decrease in the potato crop yield are more clearly represented. Clear differences occurred between the observed geographical locations as well as between the seasons: derived from the number of significant circulation types, summer and Kuressaare stand out. Of potato varieties, late 'Anti' is more influenced by circulation. Analysis of MSLP maps of circulation types revealed that the seaside stations (Tallinn, Kuressaare) suffer from negative effects of anti-cyclonic conditions (drought), while Tartu suffers from the cyclonic activity (excessive water).

Relations between winter precipitation and atmospheric circulation simulated by the Geophysical Fluid Dynamics Laboratory general circulation model

USGS Publications Warehouse

McCabe, G.J.; Dettinger, M.D.

1995-01-01

General circulation model (GCM) simulations of atmospheric circulation are more reliable than GCM simulations of temperature and precipitation. In this study, temporal correlations between 700 hPa height anomalies simulated winter precipitation at eight locations in the conterminous United States are compared with corresponding correlations in observations. The objectives are to 1) characterize the relations between atmospheric circulation and winter precipitation simulated by the GFDL, GCM for selected locations in the conterminous USA, ii) determine whether these relations are similar to those found in observations of the actual climate system, and iii) determine if GFDL-simulated precipitation is forced by the same circulation patterns as in the real atmosphere. -from Authors

Borehole model for simulation transport geothermal heat with heat pipe system and with forced circulation of heat carrier

NASA Astrophysics Data System (ADS)

Jakubský, Michal; Lenhard, Richard; Vantúch, Martin; Malcho, Milan

2012-04-01

In the call OPVaV-2008/2.2/01-SORO Operational Programme Research and Development - knowledge and technology transfer from research and development into practice (ITMS-26220220057), whose strategic goal is "Device to use low-potential geothermal heat without forced circulation of heat carrier deep in the well "in the Department of Energy laboratory techniques to construct a simulator of transport low potential of geothermal energy in comparative test-drilling in the laboratory. The article describes a device that was designed as a scale model of two deep boreholes each of which withdraws the earth's heat by heat transfer technology and heat carrier. Device using forced circulation of heat carrier will respond in the construction of equipment currently used to transport heat from deep borehole. As the heat carrier will be used CO2. Facilities without using forced circulation of heat carrier, the new technology, which will be used as heat carrier ammonia (NH3).

12 CFR 262.3 - Applications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... published. Similarly, the Board will consider comments on an application from the Attorney General or a.... Such notice shall be published in a newspaper of general circulation in— (A) [Reserved] (B) The... published in a newspaper of general circulation in the community or communities in which the head office of...

The Evolution of the Georgia Tech Library Circulation Department

ERIC Educational Resources Information Center

Glover, Karen

2006-01-01

The author reviews the evolution of the Circulation Department at the Georgia Institute of Technology (Georgia Tech) Library and Information Center from 2001 to the present. It is shown how a traditional circulation department with poor customer relations transformed itself by adopting innovative policies and services leading to improved customer…

Evaluation and Sensitivity Analysis of an Ocean Model Response to Hurricane Ivan (PREPRINT)

DTIC Science & Technology

2009-05-18

analysis of upper-limb meridional overturning circulation interior ocean pathways in the tropical/subtropical Atlantic . In: Interhemispheric Water...diminishing returns are encountered when either resolution is increased. 3 1. Introduction Coupled ocean-atmosphere general circulation models have become...northwest Caribbean Sea 4 and GOM. Evaluation is difficult because ocean general circulation models incorporate a large suite of numerical algorithms

Impact of variations of gravitational acceleration on the general circulation of the planetary atmosphere

NASA Astrophysics Data System (ADS)

Kilic, Cevahir; Raible, Christoph C.; Stocker, Thomas F.; Kirk, Edilbert

2017-01-01

Fundamental to the redistribution of energy in a planetary atmosphere is the general circulation and its meridional structure. We use a general circulation model of the atmosphere in an aquaplanet configuration with prescribed sea surface temperature and investigate the influence of the gravitational acceleration g on the structure of the circulation. For g =g0 = 9.81 ms-2 , three meridional cells exist in each hemisphere. Up to about g /g0 = 1.4 all cells increase in strength. Further increasing this ratio results in a weakening of the thermally indirect cell, such that a two- and finally a one-cell structure of the meridional circulation develops in each hemisphere. This transition is explained by the primary driver of the thermally direct Hadley cell: the diabatic heating at the equator which is proportional to g. The analysis of the energetics of the atmospheric circulation based on the Lorenz energy cycle supports this finding. For Earth-like gravitational accelerations transient eddies are primarily responsible for the meridional heat flux. For large gravitational accelerations, the direct zonal mean conversion of energy dominates the meridional heat flux.

Wake Vortex Wingtip-Turbine Powered Circulation Control High-Lift System

NASA Technical Reports Server (NTRS)

Moore, Mark D.

2005-01-01

NASA s Vehicle Systems Program is investing in aeronautics technology development across six vehicle sectors, in order to improve future air travel. These vehicle sectors include subsonic commercial transports, supersonic vehicles, Uninhabited Aerial Vehicles (UAVs), Extreme Short Takeoff and Landing (ESTOL) vehicles, Rotorcraft, and Personal Air Vehicles (PAVs). While the subsonic transport is firmly established in U.S. markets, the other vehicle sectors have not developed a sufficient technology or regulatory state to permit widespread, practical use. The PAV sector has legacy products in the General Aviation (GA) market, but currently only accounts for negligible revenue miles, sales, or market share of personal travel. In order for PAV s to ever capture a significant market, these small aircraft require technologies that permit them to be less costly, environmentally acceptable, safer, easier to operate, more efficient, and less dependent on large support infrastructures.

Balanced and Unbalanced Aspects of Tropical Cyclone Intensification

DTIC Science & Technology

2009-10-06

axisymmetric balance theory. The secondary ( overturning ) circulation and balanced tendency for the primary circulation are obtained by solving a...balance theory. The secondary ( overturning ) circulation and balanced tendency for the primary circulation are obtained by solving a general form of the... meridional circulation . This equation is often referred to as the Sawyer–Eliassen (SE) equation (Willoughby, 1979; Shapiro and Willoughby, 1982). For

The influence of the tropics upon the prediction of the Southern Hemisphere circulation within the GLAS GCM. [Goddard Laboratory for Atmospheric Sciences General Circulation Model

NASA Technical Reports Server (NTRS)

Baker, W. E.; Paegle, J.

1983-01-01

An examination is undertaken of the sensitivity of short term Southern Hemisphere circulation prediction to tropical wind data and tropical latent heat release. The data assimilation experiments employ the Goddard Laboratory for Atmospheric Sciences' fourth-order general circulation model. Two of the experiments are identical, but for the fact that one uses tropical wind data while the other does not. A third experiment contains the identical initial conditions of forecasts with tropical winds, while suppressing tropical latent heat release.

Proceedings of the 2004 NASA/ONR Circulation Control Workshop, Part 1

NASA Technical Reports Server (NTRS)

Jones, Gregory S. (Editor); Joslin, Ronald D. (Editor)

2005-01-01

As technological advances influence the efficiency and effectiveness of aerodynamic and hydrodynamic applications, designs and operations, this workshop was intended to address the technologies, systems, challenges and successes specific to Coanda driven circulation control in aerodynamics and hydrodynamics. A major goal of this workshop was to determine the 2004 state-of-the-art in circulation control and understand the roadblocks to its application. The workshop addressed applications, CFD, and experiments related to circulation control, emphasizing fundamental physics, systems analysis, and applied research. The workshop consisted of 34 single session oral presentations and written papers that focused on Naval hydrodynamic vehicles (e.g. submarines), Fixed Wing Aviation, V/STOL platforms, propulsion systems (including wind turbine systems), ground vehicles (automotive and trucks) and miscellaneous applications (e.g., poultry exhaust systems and vacuum systems). Several advanced CFD codes were benchmarked using a two-dimensional NCCR circulation control airfoil. The CFD efforts highlighted inconsistencies in turbulence modeling, separation and performance predictions.

Feasibility study: Atmospheric general circulation experiment, volume 2

NASA Technical Reports Server (NTRS)

Homsey, R. J. (Editor)

1981-01-01

The feasibility analysis of the atmospheric general circulation experiment (AGCE) are documented. The analysis performed in each technical area, the rationale and substantiation for the design approaches selected for the hardware, and the design details for the baseline AGCE are presented.

Vertical Helicity Flux as an Index of General Atmospheric Circulation

NASA Astrophysics Data System (ADS)

Kurgansky, M. V.; Maksimenkov, L. O.; Khapaev, A. A.; Chkhetiani, O. G.

2018-04-01

As an index of the general atmospheric circulation over the hemisphere, it is proposed to calculate the hemisphere-area-averaged (poleward of the latitude 20°) product of the Coriolis parameter by the wind velocity squared at the upper boundary of the planetary boundary layer. In practical calculations, data on the wind velocity at an isobaric level of 850 hPa were used. Control calculations for the 900 hPa level gave similar results. It is shown that the index introduced adequately characterizes the seasonal and interannual variability of the general atmospheric circulation over both hemispheres.

Calibrating the ECCO ocean general circulation model using Green's functions

NASA Technical Reports Server (NTRS)

Menemenlis, D.; Fu, L. L.; Lee, T.; Fukumori, I.

2002-01-01

Green's functions provide a simple, yet effective, method to test and calibrate General-Circulation-Model(GCM) parameterizations, to study and quantify model and data errors, to correct model biases and trends, and to blend estimates from different solutions and data products.

Development of the Technologies for Stabilization Treatment of the Water of the Recycling Cooling Systems at Thermal Power Plants

NASA Astrophysics Data System (ADS)

Vlasov, S. M.; Chichirova, N. D.; Chichirov, A. A.; Vlasova, A. Yu.; Filimonova, A. A.; Prosvirnina, D. V.

2018-02-01

A turbine-condensate cooling system is one of the less stable and most hard-to-control systems of maintaining optimal water chemistry. A laboratory recycling cooling water test facility, UVO-0.3, was developed for physical simulation of innovative zero-discharge water chemistry conditions and improvement of technological flowcharts of stabilization treatment of the initial and circulating water of the recycling cooling systems at thermal power plants. Experiments were conducted in the UVO-0.3 facility to investigate the processes that occur in the recycling water supply system and master new technologies of stabilization of the initial and circulating water. It is shown that, when using untreated initial water, scaling cannot be prevented even under low concentration levels. The main reason for the activation of scale depositing is the desorption of carbon dioxide that results in alkalization of the circulating water and, as a consequence, a displacement of the chemical reaction equilibrium towards the formation of slightly soluble hardness ions. Some techniques, viz., liming and alkalization of the initial water and the by-pass treatment of the circulating water, are considered. New engineering solutions have been developed for reducing the amount of scale-forming substances in the initial and circulating water. The best results were obtained by pretreating the initial water with alkalizing agents and simultaneously bypassing and treating part of the circulating water. The obtained experimental data underlie the process flowcharts of stabilization treatment of the initial and circulating TPP water that ensure scale-free and noncorrosive operation and meet the corresponding environmental requirements. Under the bypassing, the specific rates of the agents and the residual hardness are reduced compared with the conventional pretreatment.

General Anesthesia Inhibits the Activity of the “Glymphatic System”

PubMed Central

Gakuba, Clement; Gaberel, Thomas; Goursaud, Suzanne; Bourges, Jennifer; Di Palma, Camille; Quenault, Aurélien; Martinez de Lizarrondo, Sara; Vivien, Denis; Gauberti, Maxime

2018-01-01

INTRODUCTION: According to the “glymphatic system” hypothesis, brain waste clearance is mediated by a continuous replacement of the interstitial milieu by a bulk flow of cerebrospinal fluid (CSF). Previous reports suggested that this cerebral CSF circulation is only active during general anesthesia or sleep, an effect mediated by the dilatation of the extracellular space. Given the controversies regarding the plausibility of this phenomenon and the limitations of currently available methods to image the glymphatic system, we developed original whole-brain in vivo imaging methods to investigate the effects of general anesthesia on the brain CSF circulation. METHODS: We used magnetic resonance imaging (MRI) and near-infrared fluorescence imaging (NIRF) after injection of a paramagnetic contrast agent or a fluorescent dye in the cisterna magna, in order to investigate the impact of general anesthesia (isoflurane, ketamine or ketamine/xylazine) on the intracranial CSF circulation in mice. RESULTS: In vivo imaging allowed us to image CSF flow in awake and anesthetized mice and confirmed the existence of a brain-wide CSF circulation. Contrary to what was initially thought, we demonstrated that the parenchymal CSF circulation is mainly active during wakefulness and significantly impaired during general anesthesia. This effect was especially significant when high doses of anesthetic agent were used (3% isoflurane). These results were consistent across the different anesthesia regimens and imaging modalities. Moreover, we failed to detect a significant change in the brain extracellular water volume using diffusion weighted imaging in awake and anesthetized mice. CONCLUSION: The parenchymal diffusion of small molecular weight compounds from the CSF is active during wakefulness. General anesthesia has a negative impact on the intracranial CSF circulation, especially when using a high dose of anesthetic agent. PMID:29344300

General Anesthesia Inhibits the Activity of the "Glymphatic System".

PubMed

Gakuba, Clement; Gaberel, Thomas; Goursaud, Suzanne; Bourges, Jennifer; Di Palma, Camille; Quenault, Aurélien; de Lizarrondo, Sara Martinez; Vivien, Denis; Gauberti, Maxime

2018-01-01

INTRODUCTION: According to the "glymphatic system" hypothesis, brain waste clearance is mediated by a continuous replacement of the interstitial milieu by a bulk flow of cerebrospinal fluid (CSF). Previous reports suggested that this cerebral CSF circulation is only active during general anesthesia or sleep, an effect mediated by the dilatation of the extracellular space. Given the controversies regarding the plausibility of this phenomenon and the limitations of currently available methods to image the glymphatic system, we developed original whole-brain in vivo imaging methods to investigate the effects of general anesthesia on the brain CSF circulation. METHODS: We used magnetic resonance imaging (MRI) and near-infrared fluorescence imaging (NIRF) after injection of a paramagnetic contrast agent or a fluorescent dye in the cisterna magna, in order to investigate the impact of general anesthesia (isoflurane, ketamine or ketamine/xylazine) on the intracranial CSF circulation in mice. RESULTS: In vivo imaging allowed us to image CSF flow in awake and anesthetized mice and confirmed the existence of a brain-wide CSF circulation. Contrary to what was initially thought, we demonstrated that the parenchymal CSF circulation is mainly active during wakefulness and significantly impaired during general anesthesia. This effect was especially significant when high doses of anesthetic agent were used (3% isoflurane). These results were consistent across the different anesthesia regimens and imaging modalities. Moreover, we failed to detect a significant change in the brain extracellular water volume using diffusion weighted imaging in awake and anesthetized mice. CONCLUSION: The parenchymal diffusion of small molecular weight compounds from the CSF is active during wakefulness. General anesthesia has a negative impact on the intracranial CSF circulation, especially when using a high dose of anesthetic agent.

Atmospheric Diabatic Heating in Different Weather States and the General Circulation

NASA Technical Reports Server (NTRS)

Rossow, William B.; Zhang, Yuanchong; Tselioudis, George

2016-01-01

Analysis of multiple global satellite products identifies distinctive weather states of the atmosphere from the mesoscale pattern of cloud properties and quantifies the associated diabatic heating/cooling by radiative flux divergence, precipitation, and surface sensible heat flux. The results show that the forcing for the atmospheric general circulation is a very dynamic process, varying strongly at weather space-time scales, comprising relatively infrequent, strong heating events by ''stormy'' weather and more nearly continuous, weak cooling by ''fair'' weather. Such behavior undercuts the value of analyses of time-averaged energy exchanges in observations or numerical models. It is proposed that an analysis of the joint time-related variations of the global weather states and the general circulation on weather space-time scales might be used to establish useful ''feedback like'' relationships between cloud processes and the large-scale circulation.

Thermospheric dynamics during November 21-22, 1981 - Dynamics Explorer measurements and thermospheric general circulation model predictions

NASA Technical Reports Server (NTRS)

Roble, R. G.; Killeen, T. L.; Spencer, N. W.; Heelis, R. A.; Reiff, P. H.

1988-01-01

Time-dependent aurora and magnetospheric convection parameterizations have been derived from solar wind and aurora particle data for November 21-22, 1981, and are used to drive the auroral and magnetospheric convection models that are embedded in the National Center for Atmospheric Research thermospheric general circulation model (TGCM). Neutral wind speeds and transition boundaries between the midlatitude solar-driven circulation and the high-latitude magnetospheric convection-driven circulation are examined on an orbit-by-orbit basis. The results show that TGCM-calculated winds and reversal boundary locations are in generally good agreement with Dynamics Explorer 2 measurements for the orbits studied. This suggests that, at least for this particular period of relatively moderate geomagnetic activity, the TGCM parameterizations on the eveningside of the auroral oval and polar cap are adequate.

Clarifying the Dynamics of the General Circulation: Phillips's 1956 Experiment.

NASA Astrophysics Data System (ADS)

Lewis, John M.

1998-01-01

In the mid-1950s, amid heated debate over the physical mechanisms that controlled the known features of the atmosphere's general circulation, Norman Phillips simulated hemispheric motion on the high-speed computer at the Institute for Advanced Study. A simple energetically consistent model was integrated for a simulated time of approximately 1 month. Analysis of the model results clarified the respective roles of the synoptic-scale eddies (cyclones-anticyclones) and mean meridional circulation in the maintenance of the upper-level westerlies and the surface wind regimes. Furthermore, the modeled cyclones clearly linked surface frontogenesis with the upper-level Charney-Eady wave. In addition to discussing the model results in light of the controversy and ferment that surrounded general circulation theory in the 1940s-1950s, an effort is made to follow Phillips's scientific path to the experiment.

A Nonlinear Multigrid Solver for an Atmospheric General Circulation Model Based on Semi-Implicit Semi-Lagrangian Advection of Potential Vorticity

NASA Technical Reports Server (NTRS)

McCormick, S.; Ruge, John W.

1998-01-01

This work represents a part of a project to develop an atmospheric general circulation model based on the semi-Lagrangian advection of potential vorticity (PC) with divergence as the companion prognostic variable.

Assimilation of TOPEX/POSEIDON Altimeter Data into a Global Ocean Circulation Model: Are the Results Any Good?

NASA Technical Reports Server (NTRS)

Fukumori, I.; Fu, L. L.; Chao, Y.

1998-01-01

The feasibility of assimilating satellite altimetry data into a global ocean general ocean general circulation model is studied. Three years of TOPEX/POSEIDON data is analyzed using a global, three-dimensional, nonlinear primitive equation model.

Optimization of EGFR high positive cell isolation procedure by design of experiments methodology.

PubMed

Levi, Ofer; Tal, Baruch; Hileli, Sagi; Shapira, Assaf; Benhar, Itai; Grabov, Pavel; Eliaz, Noam

2015-01-01

Circulating tumor cells (CTCs) in blood circulation may play a role in monitoring and even in early detection of metastasis patients. Due to the limited presence of CTCs in blood circulation, viable CTCs isolation technology must supply a very high recovery rate. Here, we implement design of experiments (DOE) methodology in order to optimize the Bio-Ferrography (BF) immunomagnetic isolation (IMI) procedure for the EGFR high positive CTCs application. All consequent DOE phases such as screening design, optimization experiments and validation experiments were used. A significant recovery rate of more than 95% was achieved while isolating 100 EGFR high positive CTCs from 1 mL human whole blood. The recovery achievement in this research positions BF technology as one of the most efficient IMI technologies, which is ready to be challenged with patients' blood samples. © 2015 International Clinical Cytometry Society.

Exploring exomoon atmospheres with an idealized general circulation model

NASA Astrophysics Data System (ADS)

Haqq-Misra, Jacob; Heller, René

2018-06-01

Recent studies have shown that large exomoons can form in the accretion disks around super-Jovian extrasolar planets. These planets are abundant at about 1 AU from Sun-like stars, which makes their putative moons interesting for studies of habitability. Technological advances could soon make an exomoon discovery with Kepler or the upcoming CHEOPS and PLATO space missions possible. Exomoon climates might be substantially different from exoplanet climates because the day-night cycles on moons are determined by the moon's synchronous rotation with its host planet. Moreover, planetary illumination at the top of the moon's atmosphere and tidal heating at the moon's surface can be substantial, which can affect the redistribution of energy on exomoons. Using an idealized general circulation model with simplified hydrologic, radiative, and convective processes, we calculate surface temperature, wind speed, mean meridional circulation, and energy transport on a 2.5 Mars-mass moon orbiting a 10-Jupiter-mass at 1 AU from a Sun-like star. The strong thermal irradiation from a young giant planet causes the satellite's polar regions to warm, which remains consistent with the dynamically-driven polar amplification seen in Earth models that lack ice-albedo feedback. Thermal irradiation from young, luminous giant planets onto water-rich exomoons can be strong enough to induce water loss on a planet, which could lead to a runaway greenhouse. Moons that are in synchronous rotation with their host planet and do not experience a runaway greenhouse could experience substantial polar melting induced by the polar amplification of planetary illumination and geothermal heating from tidal effects.

Simulation of seasonal cloud forcing anomalies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Randall, D.A.

1990-08-01

One useful way to classify clouds is according to the processes that generate them. There are three main cloud-formation agencies: deep convection; surface evaporation; large-scale lifting in the absence of conditional instability. Although traditionally clouds have been viewed as influencing the atmospheric general circulation primarily through the release of latent heat, the atmospheric science literature contains abundant evidence that, in reality, clouds influence the general circulation through four more or less equally important effects: interactions with the solar and terrestrial radiation fields; condensation and evaporation; precipitation; small-scale circulations within the atmosphere. The most advanced of the current generation of GCMsmore » include parameterizations of all four effects. Until recently there has been lingering skepticism, in the general circulation modeling community, that the radiative effects of clouds significantly influence the atmospheric general circulation. GCMs have provided the proof that the radiative effects of clouds are important for the general circulation of the atmosphere. An important concept in analysis of the effects of clouds on climate is the cloud radiative forcing (CRF), which is defined as the difference between the radiative flux which actually occurs in the presence of clouds, and that which would occur if the clouds were removed but the atmospheric state were otherwise unchanged. We also use the term CRF to denote warming or cooling tendencies due to cloud-radiation interactions. Cloud feedback is the change in CRF that accompanies a climate change. The present study concentrates on the planetary CRF and its response to external forcing, i.e. seasonal change.« less

Circulating Tumor Cells Versus Circulating Tumor DNA in Colorectal Cancer: Pros and Cons

PubMed Central

Tan, Carlyn Rose C.; Zhou, Lanlan

2016-01-01

Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are emerging noninvasive multifunctional biomarkers in liquid biopsy allowing for early diagnosis, accurate prognosis, therapeutic target selection, spatiotemporal monitoring of metastasis, as well as monitoring response and resistance to treatment. CTCs and ctDNA are released from different tumor types at different stages and contribute complementary information for clinical decision. Although big strides have been taken in technology development for detection, isolation and characterization of CTCs and sensitive and specific detection of ctDNA, CTC-, and ctDNA-based liquid biopsies may not be widely adopted for routine cancer patient care until the suitability, accuracy, and reliability of these tests are validated and more standardized protocols are corroborated in large, independent, prospectively designed trials. This review covers CTC- and ctDNA-related technologies and their application in colorectal cancer. The promise of CTC-and ctDNA-based liquid biopsies is envisioned. PMID:27516729

Circulating Tumor Cells Versus Circulating Tumor DNA in Colorectal Cancer: Pros and Cons.

PubMed

Tan, Carlyn Rose C; Zhou, Lanlan; El-Deiry, Wafik S

2016-06-01

Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are emerging noninvasive multifunctional biomarkers in liquid biopsy allowing for early diagnosis, accurate prognosis, therapeutic target selection, spatiotemporal monitoring of metastasis, as well as monitoring response and resistance to treatment. CTCs and ctDNA are released from different tumor types at different stages and contribute complementary information for clinical decision. Although big strides have been taken in technology development for detection, isolation and characterization of CTCs and sensitive and specific detection of ctDNA, CTC-, and ctDNA-based liquid biopsies may not be widely adopted for routine cancer patient care until the suitability, accuracy, and reliability of these tests are validated and more standardized protocols are corroborated in large, independent, prospectively designed trials. This review covers CTC- and ctDNA-related technologies and their application in colorectal cancer. The promise of CTC-and ctDNA-based liquid biopsies is envisioned.

A Regression Study of Demand, Cost and Pricing Public Library Circulation Services.

ERIC Educational Resources Information Center

Stratton, Peter J.

This paper examines three aspects of the public library's circulation service: (1) a demand function for the service is estimated; (2) a long-run unit circulation cost curve is developed; and (3) using the economist's notion of "efficiency," a general model for the pricing of the circulation service is presented. The estimated demand…

40 CFR 93.156 - Public participation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... placing a notice by prominent advertisement in a daily newspaper of general circulation in the area....158 for a Federal action by placing a notice by prominent advertisement in a daily newspaper of... placing a notice by prominent advertisement in a daily newspaper of general circulation in the area...

A Wind Tunnel Model to Explore Unsteady Circulation Control for General Aviation Applications

NASA Technical Reports Server (NTRS)

Cagle, Christopher M.; Jones, Gregory S.

2002-01-01

Circulation Control airfoils have been demonstrated to provide substantial improvements in lift over conventional airfoils. The General Aviation Circular Control model is an attempt to address some of the concerns of this technique. The primary focus is to substantially reduce the amount of air mass flow by implementing unsteady flow. This paper describes a wind tunnel model that implements unsteady circulation control by pulsing internal pneumatic valves and details some preliminary results from the first test entry.

Co-Production of Electricity and Hydrogen Using a Novel Iron-based Catalyst

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hilaly, Ahmad; Georgas, Adam; Leboreiro, Jose

2011-09-30

The primary objective of this project was to develop a hydrogen production technology for gasification applications based on a circulating fluid-bed reactor and an attrition resistant iron catalyst. The work towards achieving this objective consisted of three key activities: Development of an iron-based catalyst suitable for a circulating fluid-bed reactor; Design, construction, and operation of a bench-scale circulating fluid-bed reactor system for hydrogen production; Techno-economic analysis of the steam-iron and the pressure swing adsorption hydrogen production processes. This report describes the work completed in each of these activities during this project. The catalyst development and testing program prepared and iron-basedmore » catalysts using different support and promoters to identify catalysts that had sufficient activity for cyclic reduction with syngas and steam oxidation and attrition resistance to enable use in a circulating fluid-bed reactor system. The best performing catalyst from this catalyst development program was produced by a commercial catalyst toll manufacturer to support the bench-scale testing activities. The reactor testing systems used during material development evaluated catalysts in a single fluid-bed reactor by cycling between reduction with syngas and oxidation with steam. The prototype SIP reactor system (PSRS) consisted of two circulating fluid-bed reactors with the iron catalyst being transferred between the two reactors. This design enabled demonstration of the technical feasibility of the combination of the circulating fluid-bed reactor system and the iron-based catalyst for commercial hydrogen production. The specific activities associated with this bench-scale circulating fluid-bed reactor systems that were completed in this project included design, construction, commissioning, and operation. The experimental portion of this project focused on technical demonstration of the performance of an iron-based catalyst and a circulating fluid-bed reactor system for hydrogen production. Although a technology can be technically feasible, successful commercial deployment also requires that a technology offer an economic advantage over existing commercial technologies. To effective estimate the economics of this steam-iron process, a techno-economic analysis of this steam iron process and a commercial pressure swing adsorption process were completed. The results from this analysis described in this report show the economic potential of the steam iron process for integration with a gasification plant for coproduction of hydrogen and electricity.« less

The effect of basal channels on oceanic ice-shelf melting

NASA Astrophysics Data System (ADS)

Millgate, Thomas; Holland, Paul R.; Jenkins, Adrian; Johnson, Helen L.

2013-12-01

The presence of ice-shelf basal channels has been noted in a number of Antarctic and Greenland ice shelves, but their impact on basal melting is not fully understood. Here we use the Massachusetts Institute of Technology general circulation model to investigate the effect of ice-shelf basal channels on oceanic melt rate for an idealized ice shelf resembling the floating tongue of Petermann Glacier in Greenland. The introduction of basal channels prevents the formation of a single geostrophically balanced boundary current; instead the flow is diverted up the right-hand (Coriolis-favored) side of each channel, with a return flow in the opposite direction on the left-hand side. As the prescribed number of basal channels is increased the mean basal melt rate decreases, in agreement with previous studies. For a small number of relatively wide channels the subice flow is found to be a largely geostrophic horizontal circulation. The reduction in melt rate is then caused by an increase in the relative contribution of weakly melting channel crests and keels. For a larger number of relatively narrow channels, the subice flow changes to a vertical overturning circulation. This change in circulation results in a weaker sensitivity of melt rates to channel size. The transition between the two regimes is governed by the Rossby radius of deformation. Our results explain why basal channels play an important role in regulating basal melting, increasing the stability of ice shelves.

Documentation of the GLAS fourth order general circulation model. Volume 1: Model documentation

NASA Technical Reports Server (NTRS)

Kalnay, E.; Balgovind, R.; Chao, W.; Edelmann, J.; Pfaendtner, J.; Takacs, L.; Takano, K.

1983-01-01

The volume 1, of a 3 volume technical memoranda which contains a documentation of the GLAS Fourth Order General Circulation Model is presented. Volume 1 contains the documentation, description of the stratospheric/tropospheric extension, user's guide, climatological boundary data, and some climate simulation studies.

General circulation of the South Atlantic between 5 deg N and 35 deg S

NASA Technical Reports Server (NTRS)

Ollitrault, Michel; Mercier, H.; Blanc, F.; Letraon, L. Y.

1991-01-01

The TOPEX/POSEIDON altimeter will provide the temporal mean seal level. So, secondly, we propose to compute the difference between these two surfaces (mean sea level minus general circulation dynamic topography). The result will be an estimate of the marine geoid, which is time invariant for the 5-year period under consideration. If this geoid is precise enough, it will permit a description of seasonal variability of the large-scale surface circulation. If there happens to be enough float data, it may be possible to infer the first vertical modes of this variability. Thus the main goal of our investigation is to determine the 3-D general circulation of the South Atlantic and the large-scale seasonal fluctuations. This last objective, however, may be restricted to the western part of the South Atlantic because float deployments have been scheduled only in the Brasil basin.

Numerical simulation of the circulation of the atmosphere of Titan

NASA Technical Reports Server (NTRS)

Hourdin, F.; Levan, P.; Talagrand, O.; Courtin, Regis; Gautier, Daniel; Mckay, Christopher P.

1992-01-01

A three dimensional General Circulation Model (GCM) of Titan's atmosphere is described. Initial results obtained with an economical two dimensional (2D) axisymmetric version of the model presented a strong superrotation in the upper stratosphere. Because of this result, a more general numerical study of superrotation was started with a somewhat different version of the GCM. It appears that for a slowly rotating planet which strongly absorbs solar radiation, circulation is dominated by global equator to pole Hadley circulation and strong superrotation. The theoretical study of this superrotation is discussed. It is also shown that 2D simulations systemically lead to instabilities which make 2D models poorly adapted to numerical simulation of Titan's (or Venus) atmosphere.

A potential flight evaluation of an upper-surface-blowing/circulation-control-wing concept

NASA Technical Reports Server (NTRS)

Riddle, Dennis W.; Eppel, Joseph C.

1987-01-01

The technology data base for powered lift aircraft design has advanced over the last 15 years. NASA's Quiet Short Haul Research Aircraft (QSRA) has provided a flight verification of upper surface blowing (USB) technology. The A-6 Circulation Control Wing flight demonstration aricraft has provide data for circulation control wing (CCW) technology. Recent small scale wind tunnel model tests and full scale static flow turning test have shown the potential of combining USB with CCW technology. A flight research program is deemed necessary to fully explore the performance and control aspects of CCW jet substitution for the mechanical USB Coanda flap. The required hardware design would also address questions about the development of flight weight ducts and CCW jets and the engine bleed-air capabilities vs requirements. NASA's QSRA would be an optimum flight research vehicle for modification to the USB/CCW configuration. The existing QSRA data base, the design simplicity of the QSRA wing trailing edge controls, availability of engine bleed-air, and the low risk, low cost potential of the suggested program is discussed.

Cloud-radiative effects on implied oceanic energy transport as simulated by atmospheric general circulation models

NASA Technical Reports Server (NTRS)

Gleckler, P. J.; Randall, D. A.; Boer, G.; Colman, R.; Dix, M.; Galin, V.; Helfand, M.; Kiehl, J.; Kitoh, A.; Lau, W.

1995-01-01

This paper summarizes the ocean surface net energy flux simulated by fifteen atmospheric general circulation models constrained by realistically-varying sea surface temperatures and sea ice as part of the Atmospheric Model Intercomparison Project. In general, the simulated energy fluxes are within the very large observational uncertainties. However, the annual mean oceanic meridional heat transport that would be required to balance the simulated surface fluxes is shown to be critically sensitive to the radiative effects of clouds, to the extent that even the sign of the Southern Hemisphere ocean heat transport can be affected by the errors in simulated cloud-radiation interactions. It is suggested that improved treatment of cloud radiative effects should help in the development of coupled atmosphere-ocean general circulation models.

Cyclonic circulation of Saturn's atmosphere due to tilted convection

NASA Astrophysics Data System (ADS)

Afanasyev, Y. D.; Zhang, Y.

2018-03-01

Saturn displays cyclonic vortices at its poles and the general atmospheric circulation at other latitudes is dominated by embedded zonal jets that display cyclonic circulation. The abundance of small-scale convective storms suggests that convection plays a role in producing and maintaining Saturn's atmospheric circulation. However, the dynamical influence of small-scale convection on Saturn's general circulation is not well understood. Here we present laboratory analogue experiments and propose that Saturn's cyclonic circulation can be explained by tilted convection in which buoyancy forces do not align with the planet's rotation axis. In our experiments—conducted with a cylindrical water tank that is heated at the bottom, cooled at the top and spun on a rotating table—warm rising plumes and cold sinking water generate small anticyclonic and cyclonic vortices that are qualitatively similar to Saturn's convective storms. Numerical simulations complement the experiments and show that this small-scale convection leads to large-scale cyclonic flow at the surface and anticyclonic circulation at the base of the fluid layer, with a polar vortex forming from the merging of smaller cyclonic storms that are driven polewards.

Observations and Modeling of the Transient General Circulation of the North Pacific Basin

NASA Technical Reports Server (NTRS)

McWilliams, James C.

2000-01-01

Because of recent progress in satellite altimetry and numerical modeling and the accumulation and archiving of long records of hydrographic and meteorological variables, it is becoming feasible to describe and understand the transient general circulation of the ocean (i.e., variations with spatial scales larger than a few hundred kilometers and time scales of seasonal and longer-beyond the mesoscale). We have carried out various studies in investigation of the transient general circulation of the Pacific Ocean from a coordinated analysis of satellite altimeter data, historical hydrographic gauge data, scatterometer wind observations, reanalyzed operational wind fields, and a variety of ocean circulation models. Broadly stated, our goal was to achieve a phenomenological catalogue of different possible types of large-scale, low-frequency variability, as a context for understanding the observational record. The approach is to identify the simplest possible model from which particular observed phenomena can be isolated and understood dynamically and then to determine how well these dynamical processes are represented in more complex Oceanic General Circulation Models (OGCMs). Research results have been obtained on Rossby wave propagation and transformation, oceanic intrinsic low-frequency variability, effects of surface gravity waves, pacific data analyses, OGCM formulation and developments, and OGCM simulations of forced variability.

[Circulating tumor cells: cornerstone of personalized medicine].

PubMed

Rafii, A; Vidal, F; Rathat, G; Alix-Panabières, C

2014-11-01

Cancer treatment has evolved toward personalized medicine. It is mandatory for clinicians to ascertain tumor biological features in order to optimize patients' treatment. Identification and characterization of circulating tumor cells demonstrated a prognostic value in many solid tumors. Here, we describe the main technologies for identification and characterization of circulating tumor cells and their clinical application in gynecologic and breast cancers. Copyright © 2014. Published by Elsevier Masson SAS.

40 CFR 147.3101 - Public notice of permit actions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., the Director shall also publish notice in a daily or weekly newspaper of general circulation in the... requirements of § 124.10 of this chapter, the Director shall provide to the affected Tribal government all... permit, shall publish such notice in at least two newspapers of general circulation in the area of the...

On the design of an interactive biosphere for the GLAS general circulation model

NASA Technical Reports Server (NTRS)

Mintz, Y.; Sellers, P. J.; Willmott, C. J.

1983-01-01

Improving the realism and accuracy of the GLAS general circulation model (by adding an interactive biosphere that will simulate the transfers of latent and sensible heat from land surface to atmosphere as functions of the atmospheric conditions and the morphology and physiology of the vegetation) is proposed.

Stratospheric wind errors, initial states and forecast skill in the GLAS general circulation model

NASA Technical Reports Server (NTRS)

Tenenbaum, J.

1983-01-01

Relations between stratospheric wind errors, initial states and 500 mb skill are investigated using the GLAS general circulation model initialized with FGGE data. Erroneous stratospheric winds are seen in all current general circulation models, appearing also as weak shear above the subtropical jet and as cold polar stratospheres. In this study it is shown that the more anticyclonic large-scale flows are correlated with large forecast stratospheric winds. In addition, it is found that for North America the resulting errors are correlated with initial state jet stream accelerations while for East Asia the forecast winds are correlated with initial state jet strength. Using 500 mb skill scores over Europe at day 5 to measure forecast performance, it is found that both poor forecast skill and excessive stratospheric winds are correlated with more anticyclonic large-scale flows over North America. It is hypothesized that the resulting erroneous kinetic energy contributes to the poor forecast skill, and that the problem is caused by a failure in the modeling of the stratospheric energy cycle in current general circulation models independent of vertical resolution.

Bioreactor Technology in Cardiovascular Tissue Engineering

NASA Astrophysics Data System (ADS)

Mertsching, H.; Hansmann, J.

Cardiovascular tissue engineering is a fast evolving field of biomedical science and technology to manufacture viable blood vessels, heart valves, myocar-dial substitutes and vascularised complex tissues. In consideration of the specific role of the haemodynamics of human circulation, bioreactors are a fundamental of this field. The development of perfusion bioreactor technology is a consequence of successes in extracorporeal circulation techniques, to provide an in vitro environment mimicking in vivo conditions. The bioreactor system should enable an automatic hydrodynamic regime control. Furthermore, the systematic studies regarding the cellular responses to various mechanical and biochemical cues guarantee the viability, bio-monitoring, testing, storage and transportation of the growing tissue.

The ECCO Family of State Estimates: An Overview

NASA Astrophysics Data System (ADS)

Wunsch, C.

2008-12-01

The idea of ECCO (Estimating the Circulation and Climate of the Ocean)originated in the middle 1980s, when it became apparent that a global oceanographic observing system for the general circulation would become a reality as it did through the World Ocean Circulation Experiment. Observational design involved extremely diverse technologies and oceanic flow regimes. To be physically interpretable, these diverse data and physical processes would need to be combined into a useful, coherent, whole. Such a synthesis can only be done with a skillful GCM having useful resolution. ECCO originated as an experiment to demonstrate the technical feasibility of such a synthesis and to determine if any of several possible methods was preferable. In contrast to a number of other superficially similar efforts, mainly derived from weather forecasting methods, the ECCO goal was to estimate the long-term circulation mean and its variability on climate (decadal and longer) time scales in a form exactly satisfying known equations of motion. ECCO was made feasible with the simultaneous construction of a new GCM (MIT) along with the development of an automatic differentiation (AD) software tool(now called TAF) which rendered practical the method of Lagrange multipliers (called the adjoint method in oceanography). Parallel developments of simplified sequential methods (smoothers) provided an alternative, also practical, methodology. One can now use the existing (publicly available) machinery to discuss the ocean circulation and its variability. The huge variety of issues connected with the global circulation has meant that an entire family of estimates has grown up, each having different emphases (primarily global; but some primarily regional---the tropics, the Southern Ocean); some focussed on physics---the role of eddies or sea ice). The methodology leads, usefully, to intense scrutiny of data and model errors and spatio-temporal coverage. As with any estimation problem, no uniquely 'correct' solution is now or ever going to be possible-- -only evolving best estimates. Further development of these and similar methodologies appears to be a necessary, inevitable, and growing component of oceanography and climate.

Global Observations and Understanding of the General Circulation of the Oceans

NASA Technical Reports Server (NTRS)

1984-01-01

The workshop was organized to: (1) assess the ability to obtain ocean data on a global scale that could profoundly change our understanding of the circulation; (2) identify the primary and secondary elements needed to conduct a World Ocean Circulation Experiment (WOCE); (3) if the ability is achievable, to determine what the U.S. role in such an experiment should be; and (4) outline the steps necessary to assure that an appropriate program is conducted. The consensus of the workshop was that a World Ocean Circulation Experiment appears feasible, worthwhile, and timely. Participants did agree that such a program should have the overall goal of understanding the general circulation of the global ocean well enough to be able to predict ocean response and feedback to long-term changes in the atmosphere. The overall goal, specific objectives, and recommendations for next steps in planning such an experiment are included.

Quasi-periodic oscillations in a symmetric general circulation model

NASA Technical Reports Server (NTRS)

Goswami, B. N.; Shukla, J.

1984-01-01

Observational evidence has been presented for the existence of quasi-periodic fluctuations of the tropical circulation with periods around two weeks and around 40 days. It is expected that an understanding of the mechanisms of these quasi-periodic oscillations in the tropical atmosphere will improve the predictability of the short range climate fluctuations in the tropics. The present study evolved as an outgrowth of an investigation conducted by Goswami et al. (1984). In this investigation remarkable oscillations of the Hadlay circulation for an ocean covered earth were observed. In the current study evidence is presented regarding the episodic behavior of the tropical circulation in general, and the propagation characteristics of these oscillations in the lower atmosphere. Attention is given to the results of six different experiments.

On the Freshwater Sensitivity of the Arctic-Atlantic Thermohaline Circulation

NASA Astrophysics Data System (ADS)

Lambert, E.; Eldevik, T.; Haugan, P.

2016-02-01

The North Atlantic thermohaline circulation (THC) carries heat and salt toward the Arctic. This circulation is generally believed to be inhibited by northern freshwater input as indicated by the `box-model' of Stommel (1961). The inferred freshwater-sensitivity of the THC, however, varies considerably between studies, both quantitatively and qualitatively. The northernmost branch of the Atlantic THC, which forms a double estuarine circulation in the Arctic Mediterranean, is one example where both strengthening and weakening of the circulation may occur due to increased freshwater input. We have accordingly built on Stommel's original concept to accomodate a THC similar to that in the Arctic Mediterranean. This model consists of three idealized basins, or boxes, connected by two coupled branches of circulation - the double estuary. The net transport of these two branches represents the extension of the Gulf Stream toward the Arctic. Its sensitivity to a change in freshwater forcing depends largely on the distribution of freshwater over the two northern basins. Varying this distribution opens a spectrum of qualitative behaviours ranging from Stommel's original freshwater-inhibited overturning circulation to a freshwater-facilitated estuarine circulation. Between these limiting cases, a Hopf and a cusp bifurcation divide the spectrum into three qualitative regions. In the first region, the circulation behaves similarly to Stommel's circulation, and sufficient freshwater input can induce an abrupt transition into a reversed flow; in the second, a similar transition can be found, although it does not reverse the circulation; in the third, no transition can occur and the circulation is generally facilitated by the northern freshwater input. Overall, the northern THC appears more stable than what would be inferred based on Stommel's model; it requires a larger amount and more localized freshwater input to `collapse' it, and a double estuary circulation is less prone to flow reversal.

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

PubMed Central

Haber, Daniel A.; Velculescu, Victor E.

2015-01-01

The ability to study nonhematologic cancers through noninvasive sampling of blood is one of the most exciting and rapidly advancing fields in cancer diagnostics. This has been driven both by major technologic advances, including the isolation of intact cancer cells and the analysis of cancer cell–derived DNA from blood samples, and by the increasing application of molecularly driven therapeutics, which rely on such accurate and timely measurements of critical biomarkers. Moreover, the dramatic efficacy of these potent cancer therapies drives the selection for additional genetic changes as tumors acquire drug resistance, necessitating repeated sampling of cancer cells to adjust therapy in response to tumor evolution. Together, these advanced noninvasive diagnostic capabilities and their applications in guiding precision cancer therapies are poised to change the ways in which we select and monitor cancer treatments. Significance Recent advances in technologies to analyze circulating tumor cells and circulating tumor DNA are setting the stage for real-time, noninvasive monitoring of cancer and providing novel insights into cancer evolution, invasion, and metastasis. PMID:24801577

Combination of TOPEX/POSEIDON Data with a Hydrographic Inversion for Determination of the Oceanic General Circulation and its Relation to Geoid Accuracy

NASA Technical Reports Server (NTRS)

Ganachaud, Alexandre; Wunsch, Carl; Kim, Myung-Chan; Tapley, Byron

1997-01-01

A global estimate of the absolute oceanic general circulation from a geostrophic inversion of in situ hydrographic data is tested against and then combined with an estimate obtained from TOPEX/POSEIDON altimetric data and a geoid model computed using the JGM-3 gravity-field solution. Within the quantitative uncertainties of both the hydrographic inversion and the geoid estimate, the two estimates derived by very different methods are consistent. When the in situ inversion is combined with the altimetry/geoid scheme using a recursive inverse procedure, a new solution, fully consistent with both hydrography and altimetry, is found. There is, however, little reduction in the uncertainties of the calculated ocean circulation and its mass and heat fluxes because the best available geoid estimate remains noisy relative to the purely oceanographic inferences. The conclusion drawn from this is that the comparatively large errors present in the existing geoid models now limit the ability of satellite altimeter data to improve directly the general ocean circulation models derived from in situ measurements. Because improvements in the geoid could be realized through a dedicated spaceborne gravity recovery mission, the impact of hypothetical much better, future geoid estimates on the circulation uncertainty is also quantified, showing significant hypothetical reductions in the uncertainties of oceanic transport calculations. Full ocean general circulation models could better exploit both existing oceanographic data and future gravity-mission data, but their present use is severely limited by the inability to quantify their error budgets.

Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential

PubMed Central

Immordino, Maria Laura; Dosio, Franco; Cattel, Luigi

2006-01-01

Among several promising new drug-delivery systems, liposomes represent an advanced technology to deliver active molecules to the site of action, and at present several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles (“first-generation liposomes”) to “second-generation liposomes”, in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. A significant step in the development of long-circulating liposomes came with inclusion of the synthetic polymer poly-(ethylene glycol) (PEG) in liposome composition. The presence of PEG on the surface of the liposomal carrier has been shown to extend blood-circulation time while reducing mononuclear phagocyte system uptake (stealth liposomes). This technology has resulted in a large number of liposome formulations encapsulating active molecules, with high target efficiency and activity. Further, by synthetic modification of the terminal PEG molecule, stealth liposomes can be actively targeted with monoclonal antibodies or ligands. This review focuses on stealth technology and summarizes pre-clinical and clinical data relating to the principal liposome formulations; it also discusses emerging trends of this promising technology. PMID:17717971

Documentation of the GLAS fourth order general circulation model. Volume 2: Scalar code

NASA Technical Reports Server (NTRS)

Kalnay, E.; Balgovind, R.; Chao, W.; Edelmann, D.; Pfaendtner, J.; Takacs, L.; Takano, K.

1983-01-01

Volume 2, of a 3 volume technical memoranda contains a detailed documentation of the GLAS fourth order general circulation model. Volume 2 contains the CYBER 205 scalar and vector codes of the model, list of variables, and cross references. A variable name dictionary for the scalar code, and code listings are outlined.

Circulation and rainfall climatology of a 10-year (1979 - 1988) integration with the Goddard Laboratory for atmospheres general circulation model

NASA Technical Reports Server (NTRS)

Kim, J.-H.; Sud, Y. C.

1993-01-01

A 10-year (1979-1988) integration of Goddard Laboratory for Atmospheres (GLA) general circulation model (GCM) under Atmospheric Model Intercomparison Project (AMIP) is analyzed and compared with observation. The first momentum fields of circulation variables and also hydrological variables including precipitation, evaporation, and soil moisture are presented. Our goals are (1) to produce a benchmark documentation of the GLA GCM for future model improvements; (2) to examine systematic errors between the simulated and the observed circulation, precipitation, and hydrologic cycle; (3) to examine the interannual variability of the simulated atmosphere and compare it with observation; and (4) to examine the ability of the model to capture the major climate anomalies in response to events such as El Nino and La Nina. The 10-year mean seasonal and annual simulated circulation is quite reasonable compared to the analyzed circulation, except the polar regions and area of high orography. Precipitation over tropics are quite well simulated, and the signal of El Nino/La Nina episodes can be easily identified. The time series of evaporation and soil moisture in the 12 biomes of the biosphere also show reasonable patterns compared to the estimated evaporation and soil moisture.

Speckle-correlation analysis of the microcapillary blood circulation in nail bed

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vilenskii, M A; Agafonov, D N; Zimnyakov, D A

2011-04-30

We present the results of the experimental studies of the possibility of monitoring the blood microcirculation in human finger nail bed with application of speckle-correlation analysis, based on estimating the contrast of time-averaged dynamic speckles. The hemodynamics at normal blood circulation and under conditions of partially suppressed blood circulation is analysed. A microscopic analysis is performed to visualise the structural changes in capillaries that are caused by suppressing blood circulation. The problems and prospects of speckle-correlation monitoring of the nail bed microhemodynamics under laboratory and clinical conditions are discussed. (optical technologies in biophysics and medicine)

Optical circulation in a multimode optomechanical resonator.

PubMed

Ruesink, Freek; Mathew, John P; Miri, Mohammad-Ali; Alù, Andrea; Verhagen, Ewold

2018-05-04

Breaking the symmetry of electromagnetic wave propagation enables important technological functionality. In particular, circulators are nonreciprocal components that can route photons directionally in classical or quantum photonic circuits and offer prospects for fundamental research on electromagnetic transport. Developing highly efficient circulators thus presents an important challenge, especially to realise compact reconfigurable implementations that do not rely on magnetic fields to break reciprocity. We demonstrate optical circulation utilising radiation pressure interactions in an on-chip multimode optomechanical system. Mechanically mediated optical mode conversion in a silica microtoroid provides a synthetic gauge bias for light, enabling four-port circulation that exploits tailored interference between appropriate light paths. We identify two sideband conditions under which ideal circulation is approached. This allows to experimentally demonstrate ~10 dB isolation and <3 dB insertion loss in all relevant channels. We show the possibility of actively controlling the circulator properties, enabling ideal opportunities for reconfigurable integrated nanophotonic circuits.

Automated Circulation Systems as a Source of Secondary Information.

ERIC Educational Resources Information Center

Chapin, Giny Ziegler

This report looks at the use of public library online circulation systems for the generation of in-house secondary information--such as statistical reports and mailing lists--and also considers problems in maintaining confidentiality of patron records when using online circulation systems. Based on a survey of the literature, general information…

Simulation of seasonal anomalies of atmospheric circulation using coupled atmosphere-ocean model

NASA Astrophysics Data System (ADS)

Tolstykh, M. A.; Diansky, N. A.; Gusev, A. V.; Kiktev, D. B.

2014-03-01

A coupled atmosphere-ocean model intended for the simulation of coupled circulation at time scales up to a season is developed. The semi-Lagrangian atmospheric general circulation model of the Hydrometeorological Centre of Russia, SLAV, is coupled with the sigma model of ocean general circulation developed at the Institute of Numerical Mathematics, Russian Academy of Sciences (INM RAS), INMOM. Using this coupled model, numerical experiments on ensemble modeling of the atmosphere and ocean circulation for up to 4 months are carried out using real initial data for all seasons of an annual cycle in 1989-2010. Results of these experiments are compared to the results of the SLAV model with the simple evolution of the sea surface temperature. A comparative analysis of seasonally averaged anomalies of atmospheric circulation shows prospects in applying the coupled model for forecasts. It is shown with the example of the El Niño phenomenon of 1997-1998 that the coupled model forecasts the seasonally averaged anomalies for the period of the nonstationary El Niño phase significantly better.

Prospects for using the technology of circulating fluidized bed for technically refitting Russian thermal power stations

NASA Astrophysics Data System (ADS)

Ryabov, G. A.; Folomeev, O. M.; Litun, D. S.; Sankin, D. A.; Dmitryukova, I. G.

2009-01-01

The present state and development of circulating fluidized bed (CFB) technology around the world are briefly reviewed. Questions of increasing the capacity of single boiler units and raising the parameters of steam are discussed. CFB boilers for 225- and 330-MW power units are described and their parameters are estimated as applied to the conditions of firing different Russian fuels. Indicators characterizing CFB boilers and pulverized-coal boilers are given. Capital outlays and operational costs for new coal-fired units are compared, and the results from this comparison are used to show the field of the most promising use of the CFB technology during technical refitting of Russian thermal power stations.

Red Sea circulation during marine isotope stage 5e

NASA Astrophysics Data System (ADS)

Siccha, Michael; Biton, Eli; Gildor, Hezi

2015-04-01

We have employed a regional Massachusetts Institute of Technology oceanic general circulation model of the Red Sea to investigate its circulation during marine isotope stage (MIS) 5e, the peak of the last interglacial, approximately 125 ka before present. Compared to present-day conditions, MIS 5e was characterized by higher Northern Hemisphere summer insolation, accompanied by increases in air temperature of more than 2°C and global sea level approximately 8 m higher than today. As a consequence of the increased seasonality, intensified monsoonal conditions with increased winds, rainfall, and humidity in the Red Sea region are evident in speleothem records and supported by model simulations. To assess the dominant factors responsible for the observed changes, we conducted several sensitivity experiments in which the MIS 5 boundary conditions or forcing parameters were used individually. Overall, our model simulation for the last interglacial maximum reconstructs a Red Sea that is colder, less ventilated and probably more oligotrophic than at present day. The largest alteration in Red Sea circulation and properties was found for the simulation of the northward displacement and intensification of the African tropical rain belt during MIS 5e, leading to a notable increase in the fresh water flux into the Red Sea. Such an increase significantly reduced the Red Sea salinity and exchange volume of the Red Sea with the Gulf of Aden. The Red Sea reacted to the MIS 5e insolation forcing by the expected increase in seasonal sea surface temperature amplitude and overall cooling caused by lower temperatures during deep water formation in winter.

Radiation and Dissipation of Internal Waves Generated by Geostrophic Motions Impinging on Small-Scale Topography

DTIC Science & Technology

2009-02-01

the largest zonal current in the world, which links the Atlantic , Indian and Pacific Oceans. The associated Meridional Overturning Circulation (MOC...formed in polar regions (Wunsch and Ferrari, 2004). Mixing is especially important in the Southern Ocean where the Meridional Overturning Circulation ...general circulation of the ocean and an important driver of the lower cell of the Meridional Overturning Circulation . Wunsch (1998) estimated that the

36 CFR 910.17 - Pedestrian circulation system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.17 Pedestrian circulation system...

36 CFR 910.17 - Pedestrian circulation system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.17 Pedestrian circulation system...

The influence of surface waves on water circulation in a mid-Atlantic continental shelf region

NASA Technical Reports Server (NTRS)

Whitlock, C. H.; Talay, T. A.

1974-01-01

The importance of wave-induced currents in different weather conditions and water depths (18.3 m and 36.6 m) is assessed in a mid-Atlantic continental-shelf region. A review of general circulation conditions is conducted. Factors which perturb the general circulation are examined using analytic techniques and limited experimental data. Actual wind and wave statistics for the region are examined. Relative magnitudes of the various currents are compared on a frequency of annual occurrence basis. Results indicated that wave-induced currents are often the same order of magnitude as other currents in the region and become more important at higher wind and wave conditions. Wind-wave and ocean-swell characteristics are among those parameters which must be monitored for the analytical computation of continental-shelf circulation.

Uncertainties in Carbon Dioxide Radiative Forcing in Atmospheric General Circulation Models

NASA Technical Reports Server (NTRS)

Cess, R. D.; Zhang, M.-H.; Potter, G. L.; Gates, W. L.; Taylor, K. E.; Barker, H. W.; Colman, R. A.; Fraser, J. R.; McAvaney, B. J.; Dazlich, D. A.;

Performance Analysis and Optimization on the UCLA Parallel Atmospheric General Circulation Model Code

NASA Technical Reports Server (NTRS)

Lou, John; Ferraro, Robert; Farrara, John; Mechoso, Carlos

1996-01-01

An analysis is presented of several factors influencing the performance of a parallel implementation of the UCLA atmospheric general circulation model (AGCM) on massively parallel computer systems. Several modificaitons to the original parallel AGCM code aimed at improving its numerical efficiency, interprocessor communication cost, load-balance and issues affecting single-node code performance are discussed.

Simulation of the early Martian climate using a general circulation model, DRAMATIC MGCM: Impacts of thermal inertia

NASA Astrophysics Data System (ADS)

Kamada, A.; Kuroda, T.; Kasaba, Y.; Terada, N.; Akiba, T.

2017-09-01

Our Mars General Circulation Model was used to reproduce the early Martian climate which was thought to be warm and wet. Our simulation with high thermal inertia assuming wet soils and ancient ocean/lakes succeeded in producing the surface temperature above 273K throughout a year in low-mid latitudes of northern hemisphere.

Efficient quantum circuits for dense circulant and circulant like operators

PubMed Central

Zhou, S. S.

2017-01-01

Circulant matrices are an important family of operators, which have a wide range of applications in science and engineering-related fields. They are, in general, non-sparse and non-unitary. In this paper, we present efficient quantum circuits to implement circulant operators using fewer resources and with lower complexity than existing methods. Moreover, our quantum circuits can be readily extended to the implementation of Toeplitz, Hankel and block circulant matrices. Efficient quantum algorithms to implement the inverses and products of circulant operators are also provided, and an example application in solving the equation of motion for cyclic systems is discussed. PMID:28572988

Methods of testing parameterizations: Vertical ocean mixing

NASA Technical Reports Server (NTRS)

Tziperman, Eli

1992-01-01

The ocean's velocity field is characterized by an exceptional variety of scales. While the small-scale oceanic turbulence responsible for the vertical mixing in the ocean is of scales a few centimeters and smaller, the oceanic general circulation is characterized by horizontal scales of thousands of kilometers. In oceanic general circulation models that are typically run today, the vertical structure of the ocean is represented by a few tens of discrete grid points. Such models cannot explicitly model the small-scale mixing processes, and must, therefore, find ways to parameterize them in terms of the larger-scale fields. Finding a parameterization that is both reliable and plausible to use in ocean models is not a simple task. Vertical mixing in the ocean is the combined result of many complex processes, and, in fact, mixing is one of the less known and less understood aspects of the oceanic circulation. In present models of the oceanic circulation, the many complex processes responsible for vertical mixing are often parameterized in an oversimplified manner. Yet, finding an adequate parameterization of vertical ocean mixing is crucial to the successful application of ocean models to climate studies. The results of general circulation models for quantities that are of particular interest to climate studies, such as the meridional heat flux carried by the ocean, are quite sensitive to the strength of the vertical mixing. We try to examine the difficulties in choosing an appropriate vertical mixing parameterization, and the methods that are available for validating different parameterizations by comparing model results to oceanographic data. First, some of the physical processes responsible for vertically mixing the ocean are briefly mentioned, and some possible approaches to the parameterization of these processes in oceanographic general circulation models are described in the following section. We then discuss the role of the vertical mixing in the physics of the large-scale ocean circulation, and examine methods of validating mixing parameterizations using large-scale ocean models.

Minimal modeling of the extratropical general circulation

NASA Technical Reports Server (NTRS)

O'Brien, Enda; Branscome, Lee E.

1989-01-01

The ability of low-order, two-layer models to reproduce basic features of the mid-latitude general circulation is investigated. Changes in model behavior with increased spectral resolution are examined in detail. Qualitatively correct time-mean heat and momentum balances are achieved in a beta-plane channel model which includes the first and third meridional modes. This minimal resolution also reproduces qualitatively realistic surface and upper-level winds and mean meridional circulations. Higher meridional resolution does not result in substantial changes in the latitudinal structure of the circulation. A qualitatively correct kinetic energy spectrum is produced when the resolution is high enough to include several linearly stable modes. A model with three zonal waves and the first three meridional modes has a reasonable energy spectrum and energy conversion cycle, while also satisfying heat and momentum budget requirements. This truncation reproduces the basic mechanisms and zonal circulation features that are obtained at higher resolution. The model performance improves gradually with higher resolution and is smoothly dependent on changes in external parameters.

36 CFR 910.18 - Vehicular circulation and storage systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... CORPORATION GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.18 Vehicular circulation and...

Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells.

PubMed

Jackson, Joshua M; Witek, Małgorzata A; Kamande, Joyce W; Soper, Steven A

2017-07-17

We present a critical review of microfluidic technologies and material effects on the analyses of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients. CTCs are a minimally invasive source of clinical information that can be used to prognose patient outcome, monitor minimal residual disease, assess tumour resistance to therapeutic agents, and potentially screen individuals for the early diagnosis of cancer. The performance of CTC isolation technologies depends on microfluidic architectures, the underlying principles of isolation, and the choice of materials. We present a critical review of the fundamental principles used in these technologies and discuss their performance. We also give context to how CTC isolation technologies enable downstream analysis of selected CTCs in terms of detecting genetic mutations and gene expression that could be used to gain information that may affect patient outcome.

Ensemble data assimilation in the Red Sea: sensitivity to ensemble selection and atmospheric forcing

NASA Astrophysics Data System (ADS)

Toye, Habib; Zhan, Peng; Gopalakrishnan, Ganesh; Kartadikaria, Aditya R.; Huang, Huang; Knio, Omar; Hoteit, Ibrahim

2017-07-01

We present our efforts to build an ensemble data assimilation and forecasting system for the Red Sea. The system consists of the high-resolution Massachusetts Institute of Technology general circulation model (MITgcm) to simulate ocean circulation and of the Data Research Testbed (DART) for ensemble data assimilation. DART has been configured to integrate all members of an ensemble adjustment Kalman filter (EAKF) in parallel, based on which we adapted the ensemble operations in DART to use an invariant ensemble, i.e., an ensemble Optimal Interpolation (EnOI) algorithm. This approach requires only single forward model integration in the forecast step and therefore saves substantial computational cost. To deal with the strong seasonal variability of the Red Sea, the EnOI ensemble is then seasonally selected from a climatology of long-term model outputs. Observations of remote sensing sea surface height (SSH) and sea surface temperature (SST) are assimilated every 3 days. Real-time atmospheric fields from the National Center for Environmental Prediction (NCEP) and the European Center for Medium-Range Weather Forecasts (ECMWF) are used as forcing in different assimilation experiments. We investigate the behaviors of the EAKF and (seasonal-) EnOI and compare their performances for assimilating and forecasting the circulation of the Red Sea. We further assess the sensitivity of the assimilation system to various filtering parameters (ensemble size, inflation) and atmospheric forcing.

Temporal relationships between adipocytokines and diabetes risk during puberty in Hispanic adolescents with obesity

PubMed Central

Kayser, Brandon D.; Toledo-Corral, Claudia M.; Alderete, Tanya L.; Weigensberg, Marc J.; Goran, Michael I.

2015-01-01

Objective Circulating cytokines are frequently cited as contributors to insulin resistance in children with obesity. This study examined whether circulating adipocytokines, independent of adiposity, predicted pubertal changes in insulin sensitivity (SI), insulin secretion (AIR), and β-cell function (BCF) in high-risk adolescents. Design and Methods 158 overweight/obese Hispanic adolescents were followed for a median of 4 years. Adipocytokines were measured using Luminex technology. SI, AIR, and the disposition index (DI) were derived from an intravenous glucose tolerance test and Minimal Modeling. Total fat mass (TFM) was measured by DEXA and visceral adipose tissue (VAT) by MRI. Results Surprisingly, mean IL-8, IL-1β, IL-6 and TNF-α decreased between 5% and 6.5% per year from baseline (P<0.001). Despite the general temporal trends, gaining 1-SD of VAT was associated with a 2% and 5% increase in MCP-1 and IL-8 (P<0.05). In addition, a 1-SD higher MCP-1 or IL-6 concentration at baseline was associated with a 16% and 21% greater decline in SI during puberty vs. pre-puberty (P<0.05). Conclusions Several adipocytokines decreased during adolescence and were weakly associated with VAT and lower insulin sensitivity during puberty. Circulating adipocytokines have relatively limited associations with pubertal changes in diabetes risk, however the consistent findings with MCP-1 warrant further investigation. PMID:26046253

Human rights, health, and capital accumulation in the Third World.

PubMed

Chossudovsky, M

1979-01-01

This article examines the relationship between human rights and the pattern of capital accumulation in the Third World. The repressive authoritarian State increasingly constitutes the means for enforcing the intensive exploitation of labor in Third World industrial enclaves and commercial agriculture. While the development of center capitalism has evolved toward "the Welfare State" and a framework of liberal sociodemocracy, the "peripheral State" is generally characterized by nondemocratic forms of government. This bipolarity in the state structure between center and periphery is functionally related to the international division of labor and the unity of production and circulation on a world level. The programs and policies of the center Welfare State (health, education, social security, etc.) constitute an input of "human capital" into the high-technology center labor process. Moreover, welfare programs in center countries activate the process of circulation by sustaining high levels of consumer demand. In underdeveloped countries, the underlying vacuum in the social sectors and the important allocations to military expenditure support the requirements of the peripheral labor process. Programs in health in the center and periphery are related to the bipolarity (qualification/dequalification) in the international division of labor. The social and economic functions of health programs are intimately related to the organic structure of the State and the mechanics whereby the State allocates its financial surplus in support of both capitalist production and circulation.

Selected translated abstracts of Russian-language climate-change publications. 4: General circulation models (in English;Russian)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burtis, M.D.; Razuvaev, V.N.; Sivachok, S.G.

1996-10-01

This report presents English-translated abstracts of important Russian-language literature concerning general circulation models as they relate to climate change. Into addition to the bibliographic citations and abstracts translated into English, this report presents the original citations and abstracts in Russian. Author and title indexes are included to assist the reader in locating abstracts of particular interest.

High-resolution interpolation of climate scenarios for Canada derived from general circulation model simulations

Treesearch

D. T. Price; D. W. McKenney; L. A. Joyce; R. M. Siltanen; P. Papadopol; K. Lawrence

2011-01-01

Projections of future climate were selected for four well-established general circulation models (GCMs) forced by each of three greenhouse gas (GHG) emissions scenarios recommended by the Intergovernmental Panel on Climate Change (IPCC), namely scenarios A2, A1B, and B1 of the IPCC Special Report on Emissions Scenarios. Monthly data for the period 1961-2100 were...

Y-Circulator with Dielectric Filler

DTIC Science & Technology

1981-12-10

Y , y LU UL iLU V Shch, shch SK K, k ’b 7p•• S. WA L,b/ V Y , y M m M, m bb b b H H H N N , n 33 a 9 E, e 0 o 0 0 O, o m 00 m Yu, yu n n 17 m...ii ’I ! DOC 1275 PAGE 1 Y -CIRCULATOR WITH DIELECTRIC FILLER A. K. Stolyarov, I. P. Tyukov, V. N . Shakhgedanov, A. A. Shilova. The known Y -circulators...FTD-ID( RS)T-1275-81 FOREIGN TECHNOLOGY DIVISION 0, Y -CIRCULATOR WIrH DIELECTRIC FILLER by A.K. Stolyarov, I.P. Tyukov, et

Modeling of submarine melting in Petermann Fjord, Northwestern Greenland using an ocean general circulation model

NASA Astrophysics Data System (ADS)

Cai, C.; Rignot, E. J.; Xu, Y.; An, L.

2013-12-01

Basal melting of the floating tongue of Petermann Glacier, in northwestern Greenland is by far the largest process of mass ablation. Melting of the floating tongue is controlled by the buoyancy of the melt water plume, the pressure-dependence of the melting point of sea ice, and the mixing of warm subsurface water with fresh buoyant subglacial discharge. In prior simulations of this melting process, the role of subglacial discharge has been neglected because in similar configurations (floating ice shelves) in the Antarctic, surface runoff is negligible; this is however not true in Greenland. Here, we use the Mass Institute of Technology general circulation model (MITgcm) at a high spatial resolution (10 m x 10 m) to simulate the melting process of the ice shelf in 2-D. the model is constrained by ice shelf bathymetry and ice thickness from NASA Operation IceBridge, ocean temperature/salinity data from Johnson et al. (2011), and subglacial discharge estimated from output products of the Regional Atmospheric Climate Model (RACMO). We compare the results obtained in winter (no runoff) with summer, and the sensitivity of the results to thermal forcing from the ocean, and to the magnitude of subglacial runoff. We conclude on the impact of the ocean and surface melting on the melting regime of the floating ice tongue of Petermann. This work is performed under a contract with NASA Cryosphere Program.

The Numerical Studies Program for the Atmospheric General Circulation Experiment (AGCE) for Spacelab Flights

NASA Technical Reports Server (NTRS)

Fowlis, W. W. (Editor); Davis, M. H. (Editor)

1981-01-01

The atmospheric general circulation experiment (AGCE) numerical design for Spacelab flights was studied. A spherical baroclinic flow experiment which models the large scale circulations of the Earth's atmosphere was proposed. Gravity is simulated by a radial dielectric body force. The major objective of the AGCE is to study nonlinear baroclinic wave flows in spherical geometry. Numerical models must be developed which accurately predict the basic axisymmetric states and the stability of nonlinear baroclinic wave flows. A three dimensional, fully nonlinear, numerical model and the AGCE based on the complete set of equations is required. Progress in the AGCE numerical design studies program is reported.

Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects

NASA Astrophysics Data System (ADS)

Hartmann, Carolin; Patil, Roshani; Lin, Charles P.; Niedre, Mark

2018-01-01

There are many diseases and biological processes that involve circulating cells in the bloodstream, such as cancer metastasis, immunology, reproductive medicine, and stem cell therapies. This has driven significant interest in new technologies for the study of circulating cells in small animal research models and clinically. Most currently used methods require drawing and enriching blood samples from the body, but these suffer from a number of limitations. In contrast, ‘in vivo flow cytometry’ (IVFC) refers to set of technologies that allow study of cells directly in the bloodstream of the organism in vivo. In recent years the IVFC field has grown significantly and new techniques have been developed, including fluorescence microscopy, multi-photon, photo-acoustic, and diffuse fluorescence IVFC. In this paper we review recent technical advances in IVFC, with emphasis on instrumentation, contrast mechanisms, and detection sensitivity. We also describe key applications in biomedical research, including cancer research and immunology. Last, we discuss future directions for IVFC, as well as prospects for broader adoption by the biomedical research community and translation to humans clinically.

Nanotechnology-Based Strategies for Early Cancer Diagnosis Using Circulating Tumor Cells as a Liquid Biopsy

PubMed Central

Huang, Qinqin; Wang, Yin; Chen, Xingxiang; Wang, Yimeng; Li, Zhiqiang; Du, Shiming; Wang, Lianrong; Chen, Shi

2018-01-01

Circulating tumor cells (CTCs) are cancer cells that shed from a primary tumor and circulate in the bloodstream. As a form of “tumor liquid biopsy”, CTCs provide important information for the mechanistic investigation of cancer metastasis and the measurement of tumor genotype evolution during treatment and disease progression. However, the extremely low abundance of CTCs in the peripheral blood and the heterogeneity of CTCs make their isolation and characterization major technological challenges. Recently, nanotechnologies have been developed for sensitive CTC detection; such technologies will enable better cell and molecular characterization and open up a wide range of clinical applications, including early disease detection and evaluation of treatment response and disease progression. In this review, we summarize the nanotechnology-based strategies for CTC isolation, including representative nanomaterials (such as magnetic nanoparticles, gold nanoparticles, silicon nanopillars, nanowires, nanopillars, carbon nanotubes, dendrimers, quantum dots, and graphene oxide) and microfluidic chip technologies that incorporate nanoroughened surfaces and discuss their key challenges and perspectives in CTC downstream analyses, such as protein expression and genetic mutations that may reflect tumor aggressiveness and patient outcome. PMID:29291161

Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects.

PubMed

Hartmann, Carolin; Patil, Roshani; Lin, Charles P; Niedre, Mark

2017-12-14

There are many diseases and biological processes that involve circulating cells in the bloodstream, such as cancer metastasis, immunology, reproductive medicine, and stem cell therapies. This has driven significant interest in new technologies for the study of circulating cells in small animal research models and clinically. Most currently used methods require drawing and enriching blood samples from the body, but these suffer from a number of limitations. In contrast, 'in vivo flow cytometry' (IVFC) refers to set of technologies that allow study of cells directly in the bloodstream of the organism in vivo. In recent years the IVFC field has grown significantly and new techniques have been developed, including fluorescence microscopy, multi-photon, photo-acoustic, and diffuse fluorescence IVFC. In this paper we review recent technical advances in IVFC, with emphasis on instrumentation, contrast mechanisms, and detection sensitivity. We also describe key applications in biomedical research, including cancer research and immunology. Last, we discuss future directions for IVFC, as well as prospects for broader adoption by the biomedical research community and translation to humans clinically.

Considerations in the development of circulating tumor cell technology for clinical use

PubMed Central

2012-01-01

This manuscript summarizes current thinking on the value and promise of evolving circulating tumor cell (CTC) technologies for cancer patient diagnosis, prognosis, and response to therapy, as well as accelerating oncologic drug development. Moving forward requires the application of the classic steps in biomarker development–analytical and clinical validation and clinical qualification for specific contexts of use. To that end, this review describes methods for interactive comparisons of proprietary new technologies, clinical trial designs, a clinical validation qualification strategy, and an approach for effectively carrying out this work through a public-private partnership that includes test developers, drug developers, clinical trialists, the US Food & Drug Administration (FDA) and the US National Cancer Institute (NCI). PMID:22747748

Continued Development and Application of Circulation Control Pneumatic Technology to Advanced Transport Aircraft

NASA Technical Reports Server (NTRS)

Englar, Robert J.

1998-01-01

Personnel of the Georgia Tech Research Institute (GTRI) Aerospace and Transportation Lab have completed a four-year grant program to develop and evaluate the pneumatic aerodynamic technology known as Circulation Control (CC) or Circulation Control Wing (CCW) for advanced transport aircraft. This pneumatic technology, which employs low-level blowing from tangential slots over round or near-round trailing edges of airfoils, greatly augments the circulation around a lifting or control surface and thus enhances the aerodynamic forces and moments generated by that surface. Two-dimensional force augmentations as high as 80 times the input blowing momentum coefficient have been recorded experimentally for these blown devices, thus providing returns of 8000% on the jet momentum expended. A further benefit is the absence of moving parts such as mechanical flaps, slats, spoilers, ailerons, elevators and rudders from these pneumatic surfaces, or the use of only very small, simple, blown aerodynamic surfaces on synergistic designs which integrate the lift, drag and control surfaces. The application of these devices to advanced aircraft can offer significant benefits in their performance, efficiency, simplicity, reliability, economic cost of operation, noise reduction, and safety of flight. To further develop and evaluate this potential, this research effort was conducted by GTRI under grant for the NASA Langley Research Center, Applied Aerodynamics Division, Subsonic Aerodynamics Branch, between June 14, 1993 and May 31, 1997.

Summer Study Program in Geophysical Fluid Dynamics 1989. General Circulation of the Oceans

DTIC Science & Technology

1989-11-01

Description of the Surface Circulation 2.2 A Description of the Interior Circulation 2.3 Formation Sites and Circulation of Deepwater Masses 2.4 Mode...and atmosphere, we have to follow basic laws of physics which lead us to try to solve a series of conservation equations, Mass : Dp*+ P() Du. - , ’ O.j...r~--~)(18) where,= vorticity 0 - 1 Vertically integrated mass conservation gives which leads to T.3) (19) Using the fact that Ro, ;<<I, the lowest

Circulation in the South China Sea during summer 2000 as obtained from observations and a generalized topography-following ocean model

NASA Astrophysics Data System (ADS)

Wang, Huiqun; Yuan, Yaochu; Guan, Weibing; Lou, Ruyun; Wang, Kangshan

2004-07-01

On the basis of the recently obtained hydrographic data in the South China Sea, the improved Princeton Ocean Model with a generalized topography-following coordinate system is used to study the circulation in the region during summer 2000. Several sensitivity experiments are carried out to achieve reasonable model parameters for the South China Sea (SCS). It is shown from the resting stratification experiments that the generalized topography-following coordinate scheme is better than the standard sigma grid scheme for reducing the pressure gradient errors. The combination of sea surface height anomaly derived from TOPEX/Poseidon and numerical results with both diagnostic and semidiagnostic simulations provides a consistent circulation pattern for the SCS in August, and the main circulation features can be summarized as follows: (1) There is a notable anticyclonic warm eddy southeast of Vietnam with a horizontal scale of ˜300 km, and there is a cyclonic cold eddy. The simultaneous existence of these cold and warm eddies is one of the important circulation characteristics in the SCS during summer 2000. (2) A secondary cold eddy is found east of Vietnam. (3) The northwestern part of the SCS is dominated by an anticyclonic circulation system. (4) There is also a secondary warm eddy southwest off the Luzon Island. (5) A cyclonic eddy is found west off the Borneo Island. (6) A western intensification phenomenon obviously occurs in the SCS. The dynamical mechanisms of the above-mentioned circulation pattern in the SCS are the interaction between the wind stress and bottom topography and the joint effect of baroclinicity and relief.

3D General Circulation Model of the Middle Atmosphere of Jupiter

NASA Astrophysics Data System (ADS)

Zube, Nicholas Gerard; Zhang, Xi; Li, Cheng; Le, Tianhao

2017-10-01

The characteristics of Jupiter’s large-scale stratospheric circulation remain largely unknown. Detailed distributions of temperature and photochemical species have been provided by recent observations [1], but have not yet been accurately reproduced by middle atmosphere general circulation models (GCM). Jupiter’s stratosphere and upper troposphere are influenced by radiative forcing from solar insolation and infrared cooling from hydrogen and hydrocarbons, as well as waves propagating from the underlying troposphere [2]. The relative significance of radiative and mechanical forcing on stratospheric circulation is still being debated [3]. Here we present a 3D GCM of Jupiter’s atmosphere with a correlated-k radiative transfer scheme. The simulation results are compared with observations. We analyze the impact of model parameters on the stratospheric temperature distribution and dynamical features. Finally, we discuss future tracer transport and gravity wave parameterization schemes that may be able to accurately simulate the middle atmosphere dynamics of Jupiter and other giant planets.[1] Kunde et al. 2004, Science 305, 1582.[2] Zhang et al. 2013a, EGU General Assembly, EGU2013-5797-2.[3] Conrath 1990, Icarus, 83, 255-281.

Integrated and spectral energetics of the GLAS general circulation model

NASA Technical Reports Server (NTRS)

Tenenbaum, J.

1981-01-01

Integrated and spectral error energetics of the Goddard Laboratory for Atmospheric Sciences (GLAS) general circulation model are compared with observations for periods in January 1975, 1976, and 1977. For two cases the model shows significant skill in predicting integrated energetics quantities out to two weeks, and for all three cases, the integrated monthly mean energetics show qualitative improvements over previous versions of the model in eddy kinetic energy and barotropic conversions. Fundamental difficulties remain with leakage of energy to the stratospheric level. General circulation model spectral energetics predictions are compared with the corresponding observational spectra on a day by day basis. Eddy kinetic energy can be correct while significant errors occur in the kinetic energy of wavenumber three. Single wavenumber dominance in eddy kinetic energy and the correlation of spectral kinetic and potential energy are demonstrated.

Representation of Clear and Cloudy Boundary Layers in Climate Models. Chapter 14

NASA Technical Reports Server (NTRS)

Randall, D. A.; Shao, Q.; Branson, M.

1997-01-01

The atmospheric general circulation models which are being used as components of climate models rely on their boundary layer parameterizations to produce realistic simulations of the surface turbulent fluxes of sensible heat. moisture. and momentum: of the boundary-layer depth over which these fluxes converge: of boundary layer cloudiness: and of the interactions of the boundary layer with the deep convective clouds that grow upwards from it. Two current atmospheric general circulation models are used as examples to show how these requirements are being addressed: these are version 3 of the Community Climate Model. which has been developed at the U.S. National Center for Atmospheric Research. and the Colorado State University atmospheric general circulation model. The formulations and results of both models are discussed. Finally, areas for future research are suggested.

Wireless Technology in the Library: The RIT Experience: Overview of the Project.

ERIC Educational Resources Information Center

Pitkin, Pat

2001-01-01

Provides an overview of a project at RIT (Rochester Institute of Technology) that experimented with wireless technology, including laptop computers that circulate within the library building. Discusses project requirements, including ease of use, low maintenance, and low cost; motivation, including mobility; implementation; and benefits to the…

Loosening up and Letting Go: Circulating Technology in Support of a Merged Organization

ERIC Educational Resources Information Center

Furlong, Katherine

2009-01-01

Lafayette College is an undergraduate, private liberal arts and engineering school in Easton, Pennsylvania. In 2005, Lafayette rededicated its newly renovated library, complete with shared library/instructional technology facilities and a media studio. As originally envisioned, instructional technology (ITech) would have its own separate service…

High resolution interpolation of climate scenarios for the conterminous USA and Alaska derived from general circulation model simulations

Treesearch

Linda A. Joyce; David T. Price; Daniel W. McKenney; R. Martin Siltanen; Pia Papadopol; Kevin Lawrence; David P. Coulson

2011-01-01

Projections of future climate were selected for four well-established general circulation models (GCM) forced by each of three greenhouse gas (GHG) emissions scenarios, namely A2, A1B, and B1 from the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES). Monthly data for the period 1961-2100 were downloaded mainly from the web...

Spectrum Analysis of Inertial and Subinertial Motions Based on Analyzed Winds and Wind-Driven Currents from a Primitive Equation General Ocean Circulation Model.

DTIC Science & Technology

1982-12-01

1Muter.Te Motions Based on Ana lyzed Winds and wind-driven December 1982 Currents from. a Primitive Squat ion General a.OW -love"*..* Oean Circulation...mew se"$ (comeS.... do oISN..u am ae~ 00do OWaor NUN Fourier and Rotary Spc , Analysis Modeled Inertial and Subinrtial Motion 4 Primitive Equation

Seasonal changes in the atmospheric heat balance simulated by the GISS general circulation model

NASA Technical Reports Server (NTRS)

Stone, P. H.; Chow, S.; Helfand, H. M.; Quirk, W. J.; Somerville, R. C. J.

1975-01-01

Tests of the ability of numerical general circulation models to simulate the atmosphere have focussed so far on simulations of the January climatology. These models generally present boundary conditions such as sea surface temperature, but this does not prevent testing their ability to simulate seasonal changes in atmospheric processes that accompany presented seasonal changes in boundary conditions. Experiments to simulate changes in the zonally averaged heat balance are discussed since many simplified models of climatic processes are based solely on this balance.

Detection and Characterization of Circulating Tumor Associated Cells in Metastatic Breast Cancer.

PubMed

Mu, Zhaomei; Benali-Furet, Naoual; Uzan, Georges; Znaty, Anaëlle; Ye, Zhong; Paolillo, Carmela; Wang, Chun; Austin, Laura; Rossi, Giovanna; Fortina, Paolo; Yang, Hushan; Cristofanilli, Massimo

2016-09-30

The availability of blood-based diagnostic testing using a non-invasive technique holds promise for real-time monitoring of disease progression and treatment selection. Circulating tumor cells (CTCs) have been used as a prognostic biomarker for the metastatic breast cancer (MBC). The molecular characterization of CTCs is fundamental to the phenotypic identification of malignant cells and description of the relevant genetic alterations that may change according to disease progression and therapy resistance. However, the molecular characterization of CTCs remains a challenge because of the rarity and heterogeneity of CTCs and technological difficulties in the enrichment, isolation and molecular characterization of CTCs. In this pilot study, we evaluated circulating tumor associated cells in one blood draw by size exclusion technology and cytological analysis. Among 30 prospectively enrolled MBC patients, CTCs, circulating tumor cell clusters (CTC clusters), CTCs of epithelial-mesenchymal transition (EMT) and cancer associated macrophage-like cells (CAMLs) were detected and analyzed. For molecular characterization of CTCs, size-exclusion method for CTC enrichment was tested in combination with DEPArray™ technology, which allows the recovery of single CTCs or pools of CTCs as a pure CTC sample for mutation analysis. Genomic mutations of TP53 and ESR1 were analyzed by targeted sequencing on isolated 7 CTCs from a patient with MBC. The results of genomic analysis showed heterozygous TP53 R248W mutation from one single CTC and pools of three CTCs, and homozygous TP53 R248W mutation from one single CTC and pools of two CTCs. Wild-type ESR1 was detected in the same isolated CTCs. The results of this study reveal that size-exclusion method can be used to enrich and identify circulating tumor associated cells, and enriched CTCs were characterized for genetic alterations in MBC patients, respectively.

Guided self-assembly of magnetic beads for biomedical applications

NASA Astrophysics Data System (ADS)

Gusenbauer, Markus; Nguyen, Ha; Reichel, Franz; Exl, Lukas; Bance, Simon; Fischbacher, Johann; Özelt, Harald; Kovacs, Alexander; Brandl, Martin; Schrefl, Thomas

2014-02-01

Micromagnetic beads are widely used in biomedical applications for cell separation, drug delivery, and hyperthermia cancer treatment. Here we propose to use self-organized magnetic bead structures which accumulate on fixed magnetic seeding points to isolate circulating tumor cells. The analysis of circulating tumor cells is an emerging tool for cancer biology research and clinical cancer management including the detection, diagnosis and monitoring of cancer. Microfluidic chips for isolating circulating tumor cells use either affinity, size or density capturing methods. We combine multiphysics simulation techniques to understand the microscopic behavior of magnetic beads interacting with soft magnetic accumulation points used in lab-on-chip technologies. Our proposed chip technology offers the possibility to combine affinity and size capturing with special antibody-coated bead arrangements using a magnetic gradient field created by Neodymium Iron Boron permanent magnets. The multiscale simulation environment combines magnetic field computation, fluid dynamics and discrete particle dynamics.

An investigation of anticyclonic circulation in the southern Gulf of Riga during the spring period

NASA Astrophysics Data System (ADS)

Soosaar, Edith; Maljutenko, Ilja; Raudsepp, Urmas; Elken, Jüri

2014-04-01

Previous studies of the gulf-type Region of Freshwater Influence (ROFI) have shown that circulation near the area of freshwater inflow sometimes becomes anticyclonic. Such a circulation is different from basic coastal ocean buoyancy-driven circulation where an anticyclonic bulge develops near the source and a coastal current is established along the right hand coast (in the northern hemisphere), resulting in the general cyclonic circulation. The spring (from March to June) circulation and spreading of river discharge water in the southern Gulf of Riga (GoR) in the Baltic Sea was analyzed based on the results of a 10-year simulation (1997-2006) using the General Estuarine Transport Model (GETM). Monthly mean currents in the upper layer of the GoR revealed a double gyre structure dominated either by an anticyclonic or cyclonic gyre in the near-head southeastern part and corresponding cyclonic/anticyclonic gyre in the near-mouth northwestern part of the gulf. Time series analysis of PCA and vorticity, calculated from velocity data and model sensitivity tests, showed that in spring the anticyclonic circulation in the upper layer of the southern GoR is driven primarily by the estuarine type density field. This anticyclonic circulation is enhanced by easterly winds but blocked or even reversed by westerly winds. The estuarine type density field is maintained by salt flux in the northwestern connection to the Baltic Proper and river discharge in the southern GoR.

An investigation of anticyclonic circulation in the southern Gulf of Riga during the spring period

NASA Astrophysics Data System (ADS)

Soosaar, Edith; Maljutenko, Ilja; Raudsepp, Urmas; Elken, Jüri

2015-04-01

Previous studies of the gulf-type Region of Freshwater Influence (ROFI) have shown that circulation near the area of freshwater inflow sometimes becomes anticyclonic. Such a circulation is different from basic coastal ocean buoyancy-driven circulation where an anticyclonic bulge develops near the source and a coastal current is established along the right hand coast (in the northern hemisphere), resulting in the general cyclonic circulation. The spring (from March to June) circulation and spreading of river discharge water in the southern Gulf of Riga (GoR) in the Baltic Sea was analyzed based on the results of a 10-year simulation (1997-2006) using the General Estuarine Transport Model (GETM). Monthly mean currents in the upper layer of the GoR revealed a double gyre structure dominated either by an anticyclonic or cyclonic gyre in the near-head southeastern part and corresponding cyclonic/anticyclonic gyre in the near-mouth northwestern part of the gulf. Time series analysis of PCA and vorticity, calculated from velocity data and model sensitivity tests, showed that in spring the anticyclonic circulation in the upper layer of the southern GoR is driven primarily by the estuarine type density field. This anticyclonic circulation is enhanced by easterly winds but blocked or even reversed by westerly winds. The estuarine type density field is maintained by salt flux in the northwestern connection to the Baltic Proper and river discharge in the southern GoR.

EMERGING TECHNOLOGY BULLETIN: SPOUTED BED REACTOR

EPA Science Inventory

The Spouted Bed Reactor (SBR) technology utilizes the unique attributes of the "spouting " fluidization regime, which can provide heat transfer rates comparable to traditional fluid beds, while providing robust circulation of highly heterogeneous solids, concurrent with very agg...

The puzzling Venusian polar atmospheric structure reproduced by a general circulation model

PubMed Central

Ando, Hiroki; Sugimoto, Norihiko; Takagi, Masahiro; Kashimura, Hiroki; Imamura, Takeshi; Matsuda, Yoshihisa

2016-01-01

Unlike the polar vortices observed in the Earth, Mars and Titan atmospheres, the observed Venus polar vortex is warmer than the midlatitudes at cloud-top levels (∼65 km). This warm polar vortex is zonally surrounded by a cold latitude band located at ∼60° latitude, which is a unique feature called ‘cold collar' in the Venus atmosphere. Although these structures have been observed in numerous previous observations, the formation mechanism is still unknown. Here we perform numerical simulations of the Venus atmospheric circulation using a general circulation model, and succeed in reproducing these puzzling features in close agreement with the observations. The cold collar and warm polar region are attributed to the residual mean meridional circulation enhanced by the thermal tide. The present results strongly suggest that the thermal tide is crucial for the structure of the Venus upper polar atmosphere at and above cloud levels. PMID:26832195

Two phase gap cooling of an electrical machine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shoykhet, Boris A.

2016-10-04

An electro-dynamic machine has a rotor and stator with a gap therebetween. The machine has a frame defining a hollow interior with end cavities on axially opposite ends of the frame. A gas circulating system has an inlet that supplies high pressure gas to the frame interior and an outlet to collect gas passing therethrough. A liquid coolant circulating system has an inlet that supplies coolant to the frame interior and an outlet that collects coolant passing therethrough. The coolant inlet and gas inlet are generally located on the frame in a manner to allow coolant from the coolant inletmore » to flow with gas from the gas inlet to the gap. The coolant outlet and gas outlet are generally located on the frame in a manner to allow the coolant to be separated from the gas with the separated coolant and gas collected for circulation through their respective circulating systems.« less

Theoretical and experimental design studies for the Atmospheric General Circulation Experiment

NASA Technical Reports Server (NTRS)

Fowlis, W. W.; Hathaway, D. H.; Miller, T. L.; Roberts, G. O.; Kopecky, K. J.

1985-01-01

The major criterion for the Atmospheric General Circulation Experiment (AGCE) design is that it be possible to realize strong baroclinic instability in the spherical configuration chosen. A configuration was selected in which a hemispherical shell of fluid is subjected to latitudinal temperature gradients on its spherical boundaries and the latitudinal boundaries are insulators. Work in the laboratory with a cylindrical version of this configuration revealed more instabilities than baroclinic instability. Since researchers fully expect these additional instabilities to appear in the spherical configuration also, they decided to continue the laboratory cylindrical annulus studies. Four flow regimes were identified: an axisymmetric Hadley circulation, boundary layer convection, baroclinic waves and deep thermal convection. Regime diagrams were prepared.

Impact of satellite-based data on FGGE general circulation statistics

NASA Technical Reports Server (NTRS)

Salstein, David A.; Rosen, Richard D.; Baker, Wayman E.; Kalnay, Eugenia

1987-01-01

The NASA Goddard Laboratory for Atmospheres (GLA) analysis/forecast system was run in two different parallel modes in order to evaluate the influence that data from satellites and other FGGE observation platforms can have on analyses of large scale circulation; in the first mode, data from all observation systems were used, while in the second only conventional upper air and surface reports were used. The GLA model was also integrated for the same period without insertion of any data; an independent objective analysis based only on rawinsonde and pilot balloon data is also performed. A small decrease in the vigor of the general circulation is noted to follow from the inclusion of satellite observations.

A January angular momentum balance in the OSU two-level atmospheric general circulation model

NASA Technical Reports Server (NTRS)

Kim, J.-W.; Grady, W.

1982-01-01

The present investigation is concerned with an analysis of the atmospheric angular momentum balance, based on the simulation data of the Oregon State University two-level atmospheric general circulation model (AGCM). An attempt is also made to gain an understanding of the involved processes. Preliminary results on the angular momentum and mass balance in the AGCM are shown. The basic equations are examined, and questions of turbulent momentum transfer are investigated. The methods of analysis are discussed, taking into account time-averaged balance equations, time and longitude-averaged balance equations, mean meridional circulation, the mean meridional balance of relative angular momentum, and standing and transient components of motion.

Quantitation of fetal DNA fraction in maternal plasma using circulating single molecule amplification and re-sequencing technology (cSMART).

PubMed

Song, Yijun; Zhou, Xiya; Huang, Saiqiong; Li, Xiaohong; Qi, Qingwei; Jiang, Yulin; Liu, Yiqian; Ma, Chengcheng; Li, Zhifeng; Xu, Mengnan; Cram, David S; Liu, Juntao

2016-05-01

Calculation of the fetal DNA fraction (FF) is important for reliable and accurate noninvasive prenatal testing (NIPT) for fetal genetic abnormalities. The aim of the study was to develop and validate a novel method for FF determination. FF was calculated using the chromosome Y (ChrY) sequence read assay and by circulating single molecule amplification and re-sequencing technology of 76 autosomal SNPs. By Pearson correlation for FF (4.73-22.11%) in 33 male pregnancy samples, the R(2) co-efficient for the 76-SNP versus the ChrY assay was 0.9572 (p<0.001). In addition, the co-efficient of variation (CV) of FF measurement by the 76-SNP assay was low (0.15-0.35). As a control, the FF measurement for four non-pregnant plasma samples was virtually zero. In prospective longitudinal studies of 14 women with normal pregnancies, FF generally increased with gestational age. However, in eight women (71%) there was a significant decrease in FF between the first trimester (11-13 weeks) and the second trimester (15-19 weeks), and this was attributable to significant maternal weight gain. The novel 76-SNP cSMART assay has the precision to accurately measure FF in all pregnancies at a detection threshold of 5%. Based on FF trends in individual pregnancies, our results suggest that the end of the first trimester may be a more optimal window for performing NIPT. Copyright © 2016 Elsevier B.V. All rights reserved.

Renewed circulation scheme of the Baltic Sea - based on the 40-year simulation with GETM.

NASA Astrophysics Data System (ADS)

Maljutenko, Ilja; Raudsepp, Urmas

2015-04-01

The general circulation of the Baltic Sea has been characterized as cyclonic in all sub-basins based on numerous measurements and model simulations. From the long-term hydrodynamical simulation our model results have verified the general cyclonic circulation in the Baltic Proper and in the Gulf of Bothnia, but the Gulf of Finland and the Gulf of Riga have shown tendency to anticyclonic circulation. We have applied the General Estuarine Transport Model ( GETM ) for the period of 1966 - 2006 with a 1 nautical mile horizontal resolution and density adaptive bottom following vertical coordinates to make it possible to simulate horizontal and vertical density gradients with better precision. The atmospheric forcing from dynamically downscaled ERA40-HIRLAM and parametrized lateral boundary conditions are applied. Model simulation show close agreement with measurements conducted in the main monitoring stations in the BS during the simulation period. The geostrophic adjustment of density driven currents along with the upward salinity flux due to entrainment could explain the anticyclonic circulation and strong coastal current. Mean vertical velocities show that upward and downward movements are forming closed vertical circulation loops along the bottom slope of the Baltic Proper and the Gulf of Bothnia. The model has also reproduced patchy vertical movement across the BS with some distinctive areas of upward advective fluxes in the GoF along the thalweg. The distinctive areas of deepwater upwelling are also evident in the Gdansk Basin, western Gotland Basin, northern Gotland Basin and in the northen part of the Bothnia Sea.

Plausible Effect of Weather on Atlantic Meridional Overturning Circulation with a Coupled General Circulation Model

NASA Astrophysics Data System (ADS)

Liu, Zedong; Wan, Xiuquan

2018-04-01

The Atlantic meridional overturning circulation (AMOC) is a vital component of the global ocean circulation and the heat engine of the climate system. Through the use of a coupled general circulation model, this study examines the role of synoptic systems on the AMOC and presents evidence that internally generated high-frequency, synoptic-scale weather variability in the atmosphere could play a significant role in maintaining the overall strength and variability of the AMOC, thereby affecting climate variability and change. Results of a novel coupling technique show that the strength and variability of the AMOC are greatly reduced once the synoptic weather variability is suppressed in the coupled model. The strength and variability of the AMOC are closely linked to deep convection events at high latitudes, which could be strongly affected by the weather variability. Our results imply that synoptic weather systems are important in driving the AMOC and its variability. Thus, interactions between atmospheric weather variability and AMOC may be an important feedback mechanism of the global climate system and need to be taken into consideration in future climate change studies.

Interactions Between Ocean Circulation and Topography in Icy Worlds

NASA Astrophysics Data System (ADS)

Goodman, J. C.

2018-05-01

To what extent does topography at the water-rock interface control the general circulation patterns of icy world oceans? And contrariwise, to what extent does liquid flow control the topography at the ice-water interface (or interfaces)?

Use of Ocean Remote Sensing Data to Enhance Predictions with a Coupled General Circulation Model

NASA Technical Reports Server (NTRS)

Rienecker, Michele M.

1999-01-01

Surface height, sea surface temperature and surface wind observations from satellites have given a detailed time sequence of the initiation and evolution of the 1997/98 El Nino. The data have beet complementary to the subsurface TAO moored data in their spatial resolution and extent. The impact of satellite observations on seasonal prediction in the tropical Pacific using a coupled ocean-atmosphere general circulation model will be presented.

Near-inertial Wave Studies Using Historical Mooring Records and a High-Resolution General Circulation Model

DTIC Science & Technology

2009-09-30

Mooring Records and a High- Resolution General Circulation Model Harper Simmons School of Fisheries and Ocean Sciences 903 Koyukuk Drive Fairbanks AK...oceanographic community has been to develop a global internal wave prediction system analogous to those already in place for surface waves. Early steps have... Fisheries and Ocean Sciences,903 Koyukuk Drive,Fairbanks,AK,99775 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND

The role of earth radiation budget studies in climate and general circulation research

NASA Technical Reports Server (NTRS)

Ramanathan, V.

1987-01-01

The use of earth radiation budget (ERB) data for climate and general circulation research is studied. ERB measurements obtained in the 1960's and 1970's have provided data on planetary brightness, planetary global energy balances, the greenhouse effect, solar insolation, meridional heat transport by oceans and atmospheres, regional forcing, climate feedback processes, and the computation of albedo values in low latitudes. The role of clouds in governing climate, in influencing the general circulation, and in determining the sensitivity of climate to external perturbations needs to be researched; a procedure for analyzing the ERB data, which will address these problems, is described. The approach involves estimating the clear-sky fluxes from the high spatial resolution scanner measurement and defining a cloud radiative forcing; the global average of the sum of the solar and long-wave cloud forcing yields the net radiative effect of clouds on the climate.

Intercomparison and interpretation of climate feedback processes in 19 atmospheric general circulation models

NASA Technical Reports Server (NTRS)

Cess, R. D.; Potter, G. L.; Blanchet, J. P.; Boer, G. J.; Del Genio, A. D.

1990-01-01

The present study provides an intercomparison and interpretation of climate feedback processes in 19 atmospheric general circulation models. This intercomparison uses sea surface temperature change as a surrogate for climate change. The interpretation of cloud-climate interactions is given special attention. A roughly threefold variation in one measure of global climate sensitivity is found among the 19 models. The important conclusion is that most of this variation is attributable to differences in the models' depiction of cloud feedback, a result that emphasizes the need for improvements in the treatment of clouds in these models if they are ultimately to be used as reliable climate predictors. It is further emphazied that cloud feedback is the consequence of all interacting physical and dynamical processes in a general circulation model. The result of these processes is to produce changes in temperature, moisture distribution, and clouds which are integrated into the radiative response termed cloud feedback.

Parameterizing Gravity Waves and Understanding Their Impacts on Venus' Upper Atmosphere

NASA Technical Reports Server (NTRS)

Brecht, A. S.; Bougher, S. W.; Yigit, Erdal

2018-01-01

The complexity of Venus’ upper atmospheric circulation is still being investigated. Simulations of Venus’ upper atmosphere largely depend on the utility of Rayleigh Friction (RF) as a driver and necessary process to reproduce observations (i.e. temperature, density, nightglow emission). Currently, there are additional observations which provide more constraints to help characterize the driver(s) of the circulation. This work will largely focus on the impact parameterized gravity waves have on Venus’ upper atmosphere circulation within a three dimensional hydrodynamic model (Venus Thermospheric General Circulation Model).

A two-tier atmospheric circulation classification scheme for the European-North Atlantic region

NASA Astrophysics Data System (ADS)

Guentchev, Galina S.; Winkler, Julie A.

A two-tier classification of large-scale atmospheric circulation was developed for the European-North-Atlantic domain. The classification was constructed using a combination of principal components and k-means cluster analysis applied to reanalysis fields of mean sea-level pressure for 1951-2004. Separate classifications were developed for the winter, spring, summer, and fall seasons. For each season, the two classification tiers were identified independently, such that the definition of one tier does not depend on the other tier having already been defined. The first tier of the classification is comprised of supertype patterns. These broad-scale circulation classes are useful for generalized analyses such as investigations of the temporal trends in circulation frequency and persistence. The second, more detailed tier consists of circulation types and is useful for numerous applied research questions regarding the relationships between large-scale circulation and local and regional climate. Three to five supertypes and up to 19 circulation types were identified for each season. An intuitive nomenclature scheme based on the physical entities (i.e., anomaly centers) which dominate the specific patterns was used to label each of the supertypes and types. Two example applications illustrate the potential usefulness of a two-tier classification. In the first application, the temporal variability of the supertypes was evaluated. In general, the frequency and persistence of supertypes dominated by anticyclonic circulation increased during the study period, whereas the supertypes dominated by cyclonic features decreased in frequency and persistence. The usefulness of the derived circulation types was exemplified by an analysis of the circulation associated with heat waves and cold spells reported at several cities in Bulgaria. These extreme temperature events were found to occur with a small number of circulation types, a finding that can be helpful in understanding past variability and projecting future changes in the occurrence of extreme weather and climate events.

An Oceanic General Circulation Model (OGCM) investigation of the Red Sea circulation: 2. Three-dimensional circulation in the Red Sea

NASA Astrophysics Data System (ADS)

Sofianos, Sarantis S.; Johns, William E.

2003-03-01

The three-dimensional circulation of the Red Sea is studied using a set of Miami Isopycnic Coordinate Ocean Model (MICOM) simulations. The model performance is tested against the few available observations in the basin and shows generally good agreement with the main observed features of the circulation. The main findings of this analysis include an intensification of the along-axis flow toward the coasts, with a transition from western intensified boundary flow in the south to eastern intensified flow in the north, and a series of strong seasonal or permanent eddy-like features. Model experiments conducted with different forcing fields (wind-stress forcing only, surface buoyancy forcing only, or both forcings combined) showed that the circulation produced by the buoyancy forcing is stronger overall and dominates the wind-driven part of the circulation. The main circulation pattern is related to the seasonal buoyancy flux (mostly due to the evaporation), which causes the density to increase northward in the basin and produces a northward surface pressure gradient associated with the downward sloping of the sea surface. The response of the eastern boundary to the associated mean cross-basin geostrophic current depends on the stratification and β-effect. In the northern part of the basin this results in an eastward intensification of the northward surface flow associated with the presence of Kelvin waves while in the south the traditional westward intensification due to Rossby waves takes place. The most prominent gyre circulation pattern occurs in the north where a permanent cyclonic gyre is present that is involved in the formation of Red Sea Outflow Water (RSOW). Beneath the surface boundary currents are similarly intensified southward undercurrents that carry the RSOW to the sill to flow out of the basin into the Indian Ocean.

Eddy Resolving Global Ocean Prediction including Tides

DTIC Science & Technology

2013-09-30

atlantic meridional overturning circulation in the subpolar North Atlantic . Journal of Geophysical Research vol 118, doi:10.1002/jgrc,20065. [published, refereed] ...global ocean circulation model was examined using results from years 2005-2009 of a seven and a half year 1/12.5° global simulation that resolves...internal tides, along with barotropic tides and the eddying general circulation . We examined tidal amplitudes computed using 18 183-day windows that

Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects.

PubMed

Hartmann, Carolin; Patil, Roshani; Lin, Charles P; Niedre, Mark J

2017-11-08

There are many diseases and biological processes that involve circulating cells in the bloodstream, such as cancer metastasis, immune reaction/inflammation, reproductive medicine, and stem cell therapies. This has driven significant interest in new technologies for the study of circulating cells in small animal research models and clinically. Most currently used methods require drawing and enriching blood samples from the body, but these suffer from a number of limitations. In contrast, "in vivo flow cytometry" (IVFC) refers to set of technologies that allow study of cells directly in the bloodstream of the organism in vivo. In recent years the IVFC field has grown significantly and new techniques have been developed, including fluorescence microscopy, multi-photon, photo-acoustic, and diffuse fluorescence IVFC. In this paper we review recent technical advances in IVFC, with emphasis on instrumentation, contrast mechanisms, and detection sensitivity. We also describe key applications in biomedical research, including cancer research and immunology. Last, we discuss future directions for IVFC, as well as prospects for broader adoption by the biomedical research community and translation to humans clinically. © 2017 Institute of Physics and Engineering in Medicine.

Regional climates in the GISS general circulation model: Surface air temperature

NASA Technical Reports Server (NTRS)

Hewitson, Bruce

1994-01-01

One of the more viable research techniques into global climate change for the purpose of understanding the consequent environmental impacts is based on the use of general circulation models (GCMs). However, GCMs are currently unable to reliably predict the regional climate change resulting from global warming, and it is at the regional scale that predictions are required for understanding human and environmental responses. Regional climates in the extratropics are in large part governed by the synoptic-scale circulation and the feasibility of using this interscale relationship is explored to provide a way of moving to grid cell and sub-grid cell scales in the model. The relationships between the daily circulation systems and surface air temperature for points across the continental United States are first developed in a quantitative form using a multivariate index based on principal components analysis (PCA) of the surface circulation. These relationships are then validated by predicting daily temperature using observed circulation and comparing the predicted values with the observed temperatures. The relationships predict surface temperature accurately over the major portion of the country in winter, and for half the country in summer. These relationships are then applied to the surface synoptic circulation of the Goddard Institute for Space Studies (GISS) GCM control run, and a set of surface grid cell temperatures are generated. These temperatures, based on the larger-scale validated circulation, may now be used with greater confidence at the regional scale. The generated temperatures are compared to those of the model and show that the model has regional errors of up to 10 C in individual grid cells.

Cloud Feedback in Atmospheric General Circulation Models: An Update

NASA Technical Reports Server (NTRS)

Cess, R. D.; Zhang, M. H.; Ingram, W. J.; Potter, G. L.; Alekseev, V.; Barker, H. W.; Cohen-Solal, E.; Colman, R. A.; Dazlich, D. A.; DelGenio, A. D.;

Adaptation of a general circulation model to ocean dynamics

NASA Technical Reports Server (NTRS)

Turner, R. E.; Rees, T. H.; Woodbury, G. E.

1976-01-01

A primitive-variable general circulation model of the ocean was formulated in which fast external gravity waves are suppressed with rigid-lid surface constraint pressires which also provide a means for simulating the effects of large-scale free-surface topography. The surface pressure method is simpler to apply than the conventional stream function models, and the resulting model can be applied to both global ocean and limited region situations. Strengths and weaknesses of the model are also presented.

Concurrent Simulation of the Eddying General Circulation and Tides in a Global Ocean Model

DTIC Science & Technology

2010-01-01

Eddying General Circulation and Tides in a Global Ocean Model 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 0602435N 6...STATEMENT Approved for public release, distribution is unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT This paper presents a five-year global ...running 25-h average to approximately separate tidal and non-tidal components of the near-bottom flow. In contrast to earlier high-resolution global

Derivation of revised formulae for eddy viscous forces used in the ocean general circulation model

NASA Technical Reports Server (NTRS)

Chou, Ru Ling

1988-01-01

Presented is a re-derivation of the eddy viscous dissipation tensor commonly used in present oceanographic general circulation models. When isotropy is imposed, the currently-used form of the tensor fails to return to the laplacian operator. In this paper, the source of this error is identified in a consistent derivation of the tensor in both rectangular and earth spherical coordinates, and the correct form of the eddy viscous tensor is presented.

Impact of lakes and wetlands on present and future boreal climate

NASA Astrophysics Data System (ADS)

Poutou, E.; Krinner, G.; Genthon, C.

2002-12-01

Impact of lakes and wetlands on present and future boreal climate The role of lakes and wetlands in present-day high latitude climate is quantified using a general circulation model of the atmosphere. The atmospheric model includes a lake module which is presented and validated. Seasonal and spatial wetland distribution is calculated as a function of the hydrological budget of the wetlands themselves and of continental soil whose runoff feeds them. Wetland extent is simulated and discussed both in simulations forced by observed climate and in general circulation model simulations. In off-line simulations, forced by ECMWF reanalyses, the lake model simulates correctly observed lake ice durations, while the wetland extent is somewhat underestimated in the boreal regions. Coupled to the general circulation model, the lake model yields satisfying ice durations, although the climate model biases have impacts on the modeled lake ice conditions. Boreal wetland extents are overestimated in the general circulation model as simulated precipitation is too high. The impact of inundated surfaces on the simulated climate is strongest in summer when these surfaces are ice-free. Wetlands seem to play a more important role than lakes in cooling the boreal regions in summer and in humidifying the atmosphere. The role of lakes and wetlands in future climate change is evaluated by analyzing simulations of present and future climate with and without prescribed inland water bodies.

Impact of moisture variations on the circulation of the south-west monsoon

NASA Astrophysics Data System (ADS)

Kishtawal, C. M.; Pal, P. K.; Narayanan, M. S.; Manna, S. K.; Sharma, O. P.; Agarwal, Sangeeta; Upadhyaya, H. C.

1993-12-01

The impact of moisture anomalies on the circulation of the south-west Indian monsoon has been studied with a general circulation model. Newtonian relaxation is adopted to subject the model atmosphere under sustained moisture anomalies. The impact of negative anomalies of moisture was seen as a divergent circulation anomaly, while the positive anomaly was a stronger convergent anomaly. Although the humidity fields display a resilient behaviour, and relax back to normal patterns 1-2 days after the forcing terms in humidity are withdrawn, the circulation anomalies created by the moisture variation keeps growing. A feedback between positive moisture anomalies and low level convergence exists, which is terminated in the absence of external forcings.

Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

PubMed

Zhang, Wei; Xia, Wenjie; Lv, Zhengye; Ni, Chao; Xin, Yin; Yang, Liu

2017-01-01

Precision medicine and personalized medicine are based on the development of biomarkers, and liquid biopsy has been reported to be able to detect biomarkers that carry information on tumor development and progression. Compared with traditional 'solid biopsy', which cannot always be performed to determine tumor dynamics, liquid biopsy has notable advantages in that it is a noninvasive modality that can provide diagnostic and prognostic information prior to treatment, during treatment and during progression. In this review, we describe the source, characteristics, technology for detection and current situation of circulating tumor cells, circulating free DNA and exosomes used for diagnosis, recurrence monitoring, prognosis assessment and medication planning. © 2017 The Author(s)Published by S. Karger AG, Basel.

Research on the Learning Effects of Multimedia Assisted Instruction Using Information Technology Model

ERIC Educational Resources Information Center

Chen, Chen-Yuan

2012-01-01

As technology advances, whether from the previous multi-media teaching, online teaching, or now interactive whiteboard, the various changes in both hardware and software resources as well as information are very huge. The information is quickly circulating under the changes in the old and new technology, and the new knowledge has been created.…

Field Applications of In Situ Remediation Technologies: Ground-Water Circulation Wells

EPA Pesticide Factsheets

This report is one in a series that show recent pilot demonstrations and full-scale applications that treat soil and ground water in situ or increase the solubility and mobility of contaminants to improve their removal by other remediation technologies.

Tropical Cyclone Footprint in the Ocean Mixed Layer Observed by Argo in the Northwest Pacific

DTIC Science & Technology

2014-10-25

668. Hu, A., and G. A. Meehl (2009), Effect of the Atlantic hurricanes on the oceanic meridional overturning circulation and heat transport, Geo...atmospheric circulation [Hart et al., 2007]. Several studies, based on observations and modeling, suggest that TC-induced energy input and mixing may play...an important role in climate variability through regulating the oceanic general circulation and its variability [e.g., Emanuel, 2001; Sriver and Huber

Effects of Small-Scale Bathymetric Roughness on the Global Internal Wave Field

DTIC Science & Technology

2008-09-30

Navy. Much of the interest stems from the suggestion by Munk and Wunsch (1998) that the strength of the meridional overturning circulation is controlled... meridional overturning circulation . Journal of Physical Oceanography 32, 3578-3595. St. Laurent, L.C., 1999. Diapycnal advection by double diffusion...waves generated by flows over the rough seafloor. On the time scales of internal waves, mesoscale eddies and the general circulation can be regarded as

Tropical Pacific moisture variability: Its detection, synoptic structure and consequences in the general circulation

NASA Technical Reports Server (NTRS)

Mcguirk, James P.

1990-01-01

Satellite data analysis tools are developed and implemented for the diagnosis of atmospheric circulation systems over the tropical Pacific Ocean. The tools include statistical multi-variate procedures, a multi-spectral radiative transfer model, and the global spectral forecast model at NMC. Data include in-situ observations; satellite observations from VAS (moisture, infrared and visible) NOAA polar orbiters (including Tiros Operational Satellite System (TOVS) multi-channel sounding data and OLR grids) and scanning multichannel microwave radiometer (SMMR); and European Centre for Medium Weather Forecasts (ECHMWF) analyses. A primary goal is a better understanding of the relation between synoptic structures of the area, particularly tropical plumes, and the general circulation, especially the Hadley circulation. A second goal is the definition of the quantitative structure and behavior of all Pacific tropical synoptic systems. Finally, strategies are examined for extracting new and additional information from existing satellite observations. Although moisture structure is emphasized, thermal patterns are also analyzed. Both horizontal and vertical structures are studied and objective quantitative results are emphasized.

Regional climates in the GISS global circulation model - Synoptic-scale circulation

NASA Technical Reports Server (NTRS)

Hewitson, B.; Crane, R. G.

1992-01-01

A major weakness of current general circulation models (GCMs) is their perceived inability to predict reliably the regional consequences of a global-scale change, and it is these regional-scale predictions that are necessary for studies of human-environmental response. For large areas of the extratropics, the local climate is controlled by the synoptic-scale atmospheric circulation, and it is the purpose of this paper to evaluate the synoptic-scale circulation of the Goddard Institute for Space Studies (GISS) GCM. A methodology for validating the daily synoptic circulation using Principal Component Analysis is described, and the methodology is then applied to the GCM simulation of sea level pressure over the continental United States (excluding Alaska). The analysis demonstrates that the GISS 4 x 5 deg GCM Model II effectively simulates the synoptic-scale atmospheric circulation over the United States. The modes of variance describing the atmospheric circulation of the model are comparable to those found in the observed data, and these modes explain similar amounts of variance in their respective datasets. The temporal behavior of these circulation modes in the synoptic time frame are also comparable.

Near-inertial Wave Studies using Historical Mooring Records and a High-Resolution General Circulation Model

DTIC Science & Technology

2009-01-01

Mooring Records and a High- Resolution General Circulation Model Harper Simmons School of Fisheries and Ocean Sciences 903 Koyukuk Drive Fairbanks AK...oceanographic community has been to develop a global internal wave prediction system analogous to those already in place for surface waves. Early steps have...AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) School of Fisheries and Ocean

Land surface hydrology parameterization for atmospheric general circulation models including subgrid scale spatial variability

NASA Technical Reports Server (NTRS)

Entekhabi, D.; Eagleson, P. S.

1989-01-01

Parameterizations are developed for the representation of subgrid hydrologic processes in atmospheric general circulation models. Reasonable a priori probability density functions of the spatial variability of soil moisture and of precipitation are introduced. These are used in conjunction with the deterministic equations describing basic soil moisture physics to derive expressions for the hydrologic processes that include subgrid scale variation in parameters. The major model sensitivities to soil type and to climatic forcing are explored.

A Weak Constraint 4D-Var Assimilation System for the Navy Coastal Model Using the Representer Method

DTIC Science & Technology

2013-01-01

the help of the Parametric Fortrai compiler (PFC), Erwig et al. 2007 . Some general circulation models of the complexity of NCOM have seen 1 similar...the Mir general circulation model (MITgcm, Marotzke et al. 1999) also used in the ECCO consortium assimilation experiments ( Stammer et al. 2002...using the« inverse Regional Ocean Modeling System (IROMS, Di Lorenzo et al. 2007 ) with horizontal resolutions of 10 and 30km. The CCS is a large

Technical report series on global modeling and data assimilation. Volume 1: Documentation of the Goddard Earth Observing System (GEOS) General Circulation Model, version 1

NASA Technical Reports Server (NTRS)

Suarez, Max J. (Editor); Takacs, Lawrence L.; Molod, Andrea; Wang, Tina

1994-01-01

This technical report documents Version 1 of the Goddard Earth Observing System (GEOS) General Circulation Model (GCM). The GEOS-1 GCM is being used by NASA's Data Assimilation Office (DAO) to produce multiyear data sets for climate research. This report provides a documentation of the model components used in the GEOS-1 GCM, a complete description of model diagnostics available, and a User's Guide to facilitate GEOS-1 GCM experiments.

Biomarkers in Immunoglobulin Light Chain Amyloidosis.

PubMed

Kufová, Z; Sevcikova, T; Growkova, K; Vojta, P; Filipová, J; Adam, Z; Pour, L; Penka, M; Rysava, R; Němec, P; Brozova, L; Vychytilova, P; Jurczyszyn, A; Grosicki, S; Barchnicka, A; Hajdúch, M; Simicek, M; Hájek, R

2017-01-01

Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction. As amyloid depositing in target organs is irreversible, there is a big effort to identify biomarker that could help to distinguish ALA from other monoclonal gammopathies in the early stages of disease, when amyloid deposits are not fatal yet. High throughput technologies bring new opportunities to modern cancer research as they enable to study disease within its complexity. Sophisticated methods such as next generation sequencing, gene expression profiling and circulating microRNA profiling are new approaches to study aberrant plasma cells from patients with light chain amyloidosis and related diseases. While generally known mutation in multiple myeloma patients (KRAS, NRAS, MYC, TP53) were not found in ALA, number of mutated genes is comparable. Transcriptome of ALA patients proves to be more similar to monoclonal gammopathy of undetermined significance patients, moreover level of circulating microRNA, that are known to correlate with heart damage, is increased in ALA patients, where heart damage in ALA typical symptom.Key words: amyloidosis - plasma cell - genome - transcriptome - microRNA.

Rapid ice drilling with continual air transport of cuttings and cores: General concept

NASA Astrophysics Data System (ADS)

Wang, Rusheng; An, Liu; Cao, Pinlu; Chen, Baoyi; Sysoev, Mikhail; Fan, Dayou; Talalay, Pavel G.

2017-12-01

This article describes the investigation of the feasibility of rapid drilling in ice sheets and glaciers to depths of up to 600 m, with cuttings and cores continually transported by air reverse circulation. The method employs dual wall drill rods. The inner tubes provide a continuous pathway for the chips and cores from the drill bit face to the surface. To modify air reverse circulation drilling technology according to the conditions of a specific glacier, original cutter drill bits and air processing devices (air-cooled aftercoolers, air receivers, coalescing filters, desiccant dryers) should be used. The airflow velocity for conveying a 60-mm diameter and 200-mm long ice core should not be lower than 22.5 m/s, and the minimal airflow rate for continual chip and cores transport is 6.8 m3/min at 2.3-2.6 MPa. Drilling of a 600-m deep hole can be accomplished within 1.5 days in the case of 24 h drilling operations. However, to avoid sticking while drilling through ice, the drilling depth should to be limited to 540 m at a temperature of -20 °C and to 418 m at a temperature of -10 °C.

Benchtop Technologies for Circulating Tumor Cells Separation Based on Biophysical Properties

PubMed Central

Low, Wan Shi; Wan Abas, Wan Abu Bakar

2015-01-01

Circulating tumor cells (CTCs) are tumor cells that have detached from primary tumor site and are transported via the circulation system. The importance of CTCs as prognostic biomarker is leveraged when multiple studies found that patient with cutoff of 5 CTCs per 7.5 mL blood has poor survival rate. Despite its clinical relevance, the isolation and characterization of CTCs can be quite challenging due to their large morphological variability and the rare presence of CTCs within the blood. Numerous methods have been employed and discussed in the literature for CTCs separation. In this paper, we will focus on label free CTCs isolation methods, in which the biophysical and biomechanical properties of cells (e.g., size, deformability, and electricity) are exploited for CTCs detection. To assess the present state of various isolation methods, key performance metrics such as capture efficiency, cell viability, and throughput will be reported. Finally, we discuss the challenges and future perspectives of CTC isolation technologies. PMID:25977918

Flow Cytometric Methods for Circulating Tumor Cell Isolation and Molecular Analysis.

PubMed

Bhagwat, Neha; Carpenter, Erica L

2017-01-01

Circulating tumor cells provide a non-invasive source of tumor material that can be valuable at all stages of disease management, including screening and early diagnosis, monitoring response to therapy, identifying therapeutic targets, and assessing development of drug resistance. Cells isolated from the blood of cancer patients can be used for phenotypic analysis, tumor genotyping, transcriptional profiling, as well as for ex vivo culture of isolated cells. There are a variety of novel technologies currently being developed for the detection and analysis of rare cells in circulation of cancer patients. Flow cytometry is a powerful cell analysis platform that is increasingly being used in this field of study due to its relatively high throughput and versatility with respect to the large number of commercially available antibodies and fluorescent probes available to translational and clinical researchers. More importantly, it offers the ability to easily recover viable cells with high purity that are suitable for downstream molecular analysis, thus making it an attractive technology for cancer research and as a diagnostic tool.

Size-based separation methods of circulating tumor cells.

PubMed

Hao, Si-Jie; Wan, Yuan; Xia, Yi-Qiu; Zou, Xin; Zheng, Si-Yang

2018-02-01

Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the peripheral bloodstream. Compared to other "liquid biopsy" portfolios such as exosome, circulating tumor DNA/RNA (ctDNA/RNA), CTCs have incomparable advantages in analyses of transcriptomics, proteomics, and signal colocalization. Hence, CTCs hold the key to understanding the biology of metastasis and play a vital role in cancer diagnosis, treatment monitoring, and prognosis. Size-based enrichment features are prominent in CTC isolation. It is a label-free, simple and fast method. Enriched CTCs remain unmodified and viable for a wide range of subsequent analyses. In this review, we comprehensively summarize the differences of size and deformability between CTCs and blood cells, which would facilitate the development of technologies of size-based CTC isolation. Then we review representative size-/deformability-based technologies available for CTC isolation and highlight the recent achievements in molecular analysis of isolated CTCs. To wrap up, we discuss the substantial challenges facing the field, and elaborate on prospects. Copyright © 2018 Elsevier B.V. All rights reserved.

Benchtop technologies for circulating tumor cells separation based on biophysical properties.

PubMed

Low, Wan Shi; Wan Abas, Wan Abu Bakar

2015-01-01

Circulating tumor cells (CTCs) are tumor cells that have detached from primary tumor site and are transported via the circulation system. The importance of CTCs as prognostic biomarker is leveraged when multiple studies found that patient with cutoff of 5 CTCs per 7.5 mL blood has poor survival rate. Despite its clinical relevance, the isolation and characterization of CTCs can be quite challenging due to their large morphological variability and the rare presence of CTCs within the blood. Numerous methods have been employed and discussed in the literature for CTCs separation. In this paper, we will focus on label free CTCs isolation methods, in which the biophysical and biomechanical properties of cells (e.g., size, deformability, and electricity) are exploited for CTCs detection. To assess the present state of various isolation methods, key performance metrics such as capture efficiency, cell viability, and throughput will be reported. Finally, we discuss the challenges and future perspectives of CTC isolation technologies.

ESTABLISHMENT OF AN ENVIRONMENTAL CONTROL TECHNOLOGY LABORATORY WITH A CIRCULATING FLUIDIZED-BED COMBUSTION SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wei-Ping Pan; Andy Wu; John T. Riley

This report is to present the progress made on the project ''Establishment of an Environmental Control Technology Laboratory (ECTL) with a Circulating Fluidized-Bed Combustion (CFBC) System'' during the period October 1, 2004 through December 31, 2004. The following tasks have been completed. First, the renovation of the new Combustion Laboratory and the construction of the Circulating Fluidized-Bed (CFB) Combustor Building have proceeded well. Second, the detailed design of supporting and hanging structures for the CFBC was completed. Third, the laboratory-scale simulated fluidized-bed facility was modified after completing a series of pretests. The two problems identified during the pretest were solved.more » Fourth, the carbonization of chicken waste and coal was investigated in a tube furnace and a Thermogravimetric Analyzer (TGA). The experimental results from this study are presented in this report. Finally, the proposed work for the next quarter has been outlined in this report.« less

Circulation Control in NASA's Vehicle Systems

NASA Technical Reports Server (NTRS)

Rich, Paul; McKinley, Bob; Jones, Greg

2005-01-01

Specific to the application of any technology to a vehicle, such as circulation control, it is important to understand the process that NASA is using to set its direction in research and development. To see how circulation control fits into any given NASA program requires the reader to understand NASA's Vehicle Systems (VS) Program. The VS Program recently celebrated its first year of existence with an annual review - an opportunity to look back on accomplishments, solicit feedback, expand national advocacy and support for the program, and recognize key contributions. Since its formation last year, Vehicle Systems has coordinated seven existing entities in a streamlined aeronautics research effort. It invests in vehicle technologies to protect the environment, make air travel more accessible and affordable for Americans, enable exploration through new aerospace missions, and augment national security. This past year has seen a series of valuable partnerships with industry, academia, and government agencies to make crucial aeronautics advances and assure America s future in flight.

Market assessment of PFBC ash use

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bland, A. E.; Brown, T. H., Western Research Institute

1998-01-01

Pressurized fluidized bed combustion (PFBC) of coal is undergoing demonstration in the United States, as well as throughout the world. American Electric Power`s (AEP`s) bubbling PFBC 70 MWe Tidd demonstration program in Ohio and pilot-scale development at Foster Wheeler Energia Oy 10 MWth circulating PFBC at Karhula, Finland, have demonstrated the advantages of PFBC technology. Further technology development in the US is planned with the deployment of the technology at the MacIntosh Clean Coal project in Lakeland, Florida. Development of uses for solid wastes from PFBC coal-fired power systems is being actively pursued as part of the demonstration of PFBCmore » technologies. Ashes collected from Foster Wheeler Energia Oy pilot circulating PFBC tests in Karhula, Finland, operating on (1) low sulfur subbituminous and (2) high sulfur bituminous coal; and ash from the AEP`s high-sulfur bituminous coal-fired bubbling PFBC in Brilliant, Ohio, were evaluated in laboratory and pilot-scale ash use testing at Western Research Institute (WRI).« less

Application of flat panel OLED display technology for the point-of-care detection of circulating cancer biomarkers

PubMed Central

Katchman, Benjamin A.; Smith, Joseph T.; Obahiagbon, Uwadiae; Kesiraju, Sailaja; Lee, Yong-Kyun; O’Brien, Barry; Kaftanoglu, Korhan; Blain Christen, Jennifer; Anderson, Karen S.

2016-01-01

Point-of-care molecular diagnostics can provide efficient and cost-effective medical care, and they have the potential to fundamentally change our approach to global health. However, most existing approaches are not scalable to include multiple biomarkers. As a solution, we have combined commercial flat panel OLED display technology with protein microarray technology to enable high-density fluorescent, programmable, multiplexed biorecognition in a compact and disposable configuration with clinical-level sensitivity. Our approach leverages advances in commercial display technology to reduce pre-functionalized biosensor substrate costs to pennies per cm2. Here, we demonstrate quantitative detection of IgG antibodies to multiple viral antigens in patient serum samples with detection limits for human IgG in the 10 pg/mL range. We also demonstrate multiplexed detection of antibodies to the HPV16 proteins E2, E6, and E7, which are circulating biomarkers for cervical as well as head and neck cancers. PMID:27374875

Application of flat panel OLED display technology for the point-of-care detection of circulating cancer biomarkers.

PubMed

Katchman, Benjamin A; Smith, Joseph T; Obahiagbon, Uwadiae; Kesiraju, Sailaja; Lee, Yong-Kyun; O'Brien, Barry; Kaftanoglu, Korhan; Blain Christen, Jennifer; Anderson, Karen S

2016-07-04

Point-of-care molecular diagnostics can provide efficient and cost-effective medical care, and they have the potential to fundamentally change our approach to global health. However, most existing approaches are not scalable to include multiple biomarkers. As a solution, we have combined commercial flat panel OLED display technology with protein microarray technology to enable high-density fluorescent, programmable, multiplexed biorecognition in a compact and disposable configuration with clinical-level sensitivity. Our approach leverages advances in commercial display technology to reduce pre-functionalized biosensor substrate costs to pennies per cm(2). Here, we demonstrate quantitative detection of IgG antibodies to multiple viral antigens in patient serum samples with detection limits for human IgG in the 10 pg/mL range. We also demonstrate multiplexed detection of antibodies to the HPV16 proteins E2, E6, and E7, which are circulating biomarkers for cervical as well as head and neck cancers.

Oxidative Burst of Circulating Neutrophils Following Traumatic Brain Injury in Human

PubMed Central

Liao, Yiliu; Liu, Peng; Guo, Fangyuan; Zhang, Zhi-Yuan; Zhang, Zhiren

2013-01-01

Besides secondary injury at the lesional site, Traumatic brain injury (TBI) can cause a systemic inflammatory response, which may cause damage to initially unaffected organs and potentially further exacerbate the original injury. Here we investigated plasma levels of important inflammatory mediators, oxidative activity of circulating leukocytes, particularly focusing on neutrophils, from TBI subjects and control subjects with general trauma from 6 hours to 2 weeks following injury, comparing with values from uninjured subjects. We observed increased plasma level of inflammatory cytokines/molecules TNF-α, IL-6 and CRP, dramatically increased circulating leukocyte counts and elevated expression of TNF-α and iNOS in circulating leukocytes from TBI patients, which suggests a systemic inflammatory response following TBI. Our data further showed increased free radical production in leukocyte homogenates and elevated expression of key oxidative enzymes iNOS, COX-2 and NADPH oxidase (gp91phox) in circulating leukocytes, indicating an intense induction of oxidative burst following TBI, which is significantly greater than that in control subjects with general trauma. Furthermore, flow cytometry assay proved neutrophils as the largest population in circulation after TBI and showed significantly up-regulated oxidative activity and suppressed phagocytosis rate for circulating neutrophils following brain trauma. It suggests that the highly activated neutrophils might play an important role in the secondary damage, even outside the injured brain. Taken together, the potent systemic inflammatory response induced by TBI, especially the intensively increase oxidative activity of circulating leukocytes, mainly neutrophils, may lead to a systemic damage, dysfunction/damage of bystander tissues/organs and even further exacerbate secondary local damage. Controlling these pathophysiological processes may be a promising therapeutic strategy and will protect unaffected organs and the injured brain from the secondary damage. PMID:23894384

Idealised modelling of ocean circulation driven by conductive and hydrothermal fluxes at the seabed

NASA Astrophysics Data System (ADS)

Barnes, Jowan M.; Morales Maqueda, Miguel A.; Polton, Jeff A.; Megann, Alex P.

2018-02-01

Geothermal heating is increasingly recognised as an important factor affecting ocean circulation, with modelling studies suggesting that this heat source could lead to first-order changes in the formation rate of Antarctic Bottom Water, as well as a significant warming effect in the abyssal ocean. Where it has been represented in numerical models, however, the geothermal heat flux into the ocean is generally treated as an entirely conductive flux, despite an estimated one third of the global geothermal flux being introduced to the ocean via hydrothermal sources. A modelling study is presented which investigates the sensitivity of the geothermally forced circulation to the way heat is supplied to the abyssal ocean. An analytical two-dimensional model of the circulation is described, which demonstrates the effects of a volume flux through the ocean bed. A simulation using the NEMO numerical general circulation model in an idealised domain is then used to partition a heat flux between conductive and hydrothermal sources and explicitly test the sensitivity of the circulation to the formulation of the abyssal heat flux. Our simulations suggest that representing the hydrothermal flux as a mass exchange indeed changes the heat distribution in the abyssal ocean, increasing the advective heat transport from the abyss by up to 35% compared to conductive heat sources. Consequently, we suggest that the inclusion of hydrothermal fluxes can be an important addition to course-resolution ocean models.

[Advances in Liquid Biopsy and its Clinical Application in the Diagnosis 
and Treatment of Non-small Cell Lung Cancer].

PubMed

Zheng, Difan; Chen, Haiquan

2016-06-20

With the advances of technology, great progresses have been made in liquid biopsy in recent years. Liquid biopsy is currently playing a more and more important role in early diagnosis and treatment of cancer. Compared with traditional tissue biopsy, liquid biopsy is more popular in clinical practice due to its non-invasiveness, convenience and high repeatability. It has huge potential in the future. This review introduces circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) as the most important objects in liquid biopsy, mainly focusing on their history, biological characteristics, detection technologies, limitations and applications in non-small cell lung cancer.

Potential effects of climate change on ground water in Lansing, Michigan

USGS Publications Warehouse

Croley, T.E.; Luukkonen, C.L.

2003-01-01

Computer simulations involving general circulation models, a hydrologic modeling system, and a ground water flow model indicate potential impacts of selected climate change projections on ground water levels in the Lansing, Michigan, area. General circulation models developed by the Canadian Climate Centre and the Hadley Centre generated meteorology estimates for 1961 through 1990 (as a reference condition) and for the 20 years centered on 2030 (as a changed climate condition). Using these meteorology estimates, the Great Lakes Environmental Research Laboratory's hydrologic modeling system produced corresponding period streamflow simulations. Ground water recharge was estimated from the streamflow simulations and from variables derived from the general circulation models. The U.S. Geological Survey developed a numerical ground water flow model of the Saginaw and glacial aquifers in the Tri-County region surrounding Lansing, Michigan. Model simulations, using the ground water recharge estimates, indicate changes in ground water levels. Within the Lansing area, simulated ground water levels in the Saginaw aquifer declined under the Canadian predictions and increased under the Hadley.

Technical Report Series on Global Modeling and Data Assimilation. Volume 16; Filtering Techniques on a Stretched Grid General Circulation Model

NASA Technical Reports Server (NTRS)

Takacs, Lawrence L.; Sawyer, William; Suarez, Max J. (Editor); Fox-Rabinowitz, Michael S.

1999-01-01

This report documents the techniques used to filter quantities on a stretched grid general circulation model. Standard high-latitude filtering techniques (e.g., using an FFT (Fast Fourier Transformations) to decompose and filter unstable harmonics at selected latitudes) applied on a stretched grid are shown to produce significant distortions of the prognostic state when used to control instabilities near the pole. A new filtering technique is developed which accurately accounts for the non-uniform grid by computing the eigenvectors and eigenfrequencies associated with the stretching. A filter function, constructed to selectively damp those modes whose associated eigenfrequencies exceed some critical value, is used to construct a set of grid-spaced weights which are shown to effectively filter without distortion. Both offline and GCM (General Circulation Model) experiments are shown using the new filtering technique. Finally, a brief examination is also made on the impact of applying the Shapiro filter on the stretched grid.

Integrated and spectral energetics of the GLAS general circulation model

NASA Technical Reports Server (NTRS)

Tenenbaum, J.

1982-01-01

Integrated and spectral error energetics of the GLAS General circulation model are compared with observations for periods in January 1975, 1976, and 1977. For two cases the model shows significant skill in predicting integrated energetics quantities out to two weeks, and for all three cases, the integrated monthly mean energetics show qualitative improvements over previous versions of the model in eddy kinetic energy and barotropic conversions. Fundamental difficulties remain with leakage of energy to the stratospheric level, particularly above strong initial jet streams associated in part with regions of steep terrain. The spectral error growth study represents the first comparison of general circulation model spectral energetics predictions with the corresponding observational spectra on a day by day basis. The major conclusion is that eddy kinetics energy can be correct while significant errors occur in the kinetic energy of wavenumber 3. Both the model and observations show evidence of single wavenumber dominance in eddy kinetic energy and the correlation of spectral kinetics and potential energy.

The 0.125 degree finite-volume General Circulation Model on the NASA Columbia Supercomputer: Preliminary Simulations of Mesoscale Vortices

NASA Technical Reports Server (NTRS)

Shen, B.-W.; Atlas, R.; Chern, J.-D.; Reale, O.; Lin, S.-J.; Lee, T.; Chang, J.

2005-01-01

The NASA Columbia supercomputer was ranked second on the TOP500 List in November, 2004. Such a quantum jump in computing power provides unprecedented opportunities to conduct ultra-high resolution simulations with the finite-volume General Circulation Model (fvGCM). During 2004, the model was run in realtime experimentally at 0.25 degree resolution producing remarkable hurricane forecasts [Atlas et al., 2005]. In 2005, the horizontal resolution was further doubled, which makes the fvGCM comparable to the first mesoscale resolving General Circulation Model at the Earth Simulator Center [Ohfuchi et al., 2004]. Nine 5-day 0.125 degree simulations of three hurricanes in 2004 are presented first for model validation. Then it is shown how the model can simulate the formation of the Catalina eddies and Hawaiian lee vortices, which are generated by the interaction of the synoptic-scale flow with surface forcing, and have never been reproduced in a GCM before.)

The Latest on the Venus Thermospheric General Circulation Model: Capabilities and Simulations

NASA Technical Reports Server (NTRS)

Brecht, A. S.; Bougher, S. W.; Parkinson, C. D.

2017-01-01

Venus has a complex and dynamic upper atmosphere. This has been observed many times by ground-based, orbiters, probes, and fly-by missions going to other planets. Two over-arching questions are generally asked when examining the Venus upper atmosphere: (1) what creates the complex structure in the atmosphere, and (2) what drives the varying dynamics. A great way to interpret and connect observations to address these questions utilizes numerical modeling; and in the case of the middle and upper atmosphere (above the cloud tops), a 3D hydrodynamic numerical model called the Venus Thermospheric General Circulation Model (VTGCM) can be used. The VTGCM can produce climatological averages of key features in comparison to observations (i.e. nightside temperature, O2 IR nightglow emission). More recently, the VTGCM has been expanded to include new chemical constituents and airglow emissions, as well as new parameterizations to address waves and their impact on the varying global circulation and corresponding airglow distributions.

A general circulation model study of the solar and QBO modulation of the stratospheric circulation during the northern hemisphere winter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kodera, Kunihiko; Chiba, Masaru; Shibata, Kiyotaka

1991-07-01

A general circulation model has been used to study the modulation of north-polar temperatures during winter by both solar activity and the equatorial quasi-biennial oscillation (QBO). The variation of solar activity was simulated by changing the heating rate due to the absorption of ultraviolet (UV) radiation by ozone, while the QBO zonal wind fields were reproduced by incorporating zonal-momentum sources in the equatorial stratosphere. A total of 10 experiments were conducted by changing the heating rate from 70 to 110% for each of the simulated QBO easterly and westerly cases. The results of the numerical experiments show modulation effects similarmore » to those found by Labitzke (1987) in the 30-mb temperatures at the North Pole.« less

Diffuse fluorescence fiber probe for in vivo detection of circulating cells

NASA Astrophysics Data System (ADS)

Pera, Vivian; Tan, Xuefei; Runnels, Judith; Sardesai, Neha; Lin, Charles P.; Niedre, Mark

2017-03-01

There has been significant recent interest in the development of technologies for enumeration of rare circulating cells directly in the bloodstream in many areas of research, for example, in small animal models of circulating tumor cell dissemination during cancer metastasis. We describe a fiber-based optical probe that allows fluorescence detection of labeled circulating cells in vivo in a diffuse reflectance configuration. We validated this probe in a tissue-mimicking flow phantom model in vitro and in nude mice injected with fluorescently labeled multiple myeloma cells in vivo. Compared to our previous work, this design yields an improvement in detection signal-to-noise ratio of 10 dB, virtually eliminates problematic motion artifacts due to mouse breathing, and potentially allows operation in larger animals and limbs.

Potential Technology Transfer to the DoD Unmanned Ground Vehicle Program.

DTIC Science & Technology

1996-10-01

Germany. This process combines x-ray lithography, galvanic casting, and micromolding technology and can be used to produce a variety of sensors and...whether circulation is being obstructed by atherosclerosis . Finally, work is being done at the University of Minnesota on a microrobotic device

System Analyses of Pneumatic Technology for High Speed Civil Transport Aircraft

NASA Technical Reports Server (NTRS)

Mavris, Dimitri N.; Tai, Jimmy C.; Kirby, Michelle M.; Roth, Bryce A.

1999-01-01

The primary aspiration of this study was to objectively assess the feasibility of the application of a low speed pneumatic technology, in particular Circulation Control (CC) to an HSCT concept. Circulation Control has been chosen as an enabling technology to be applied on a generic High Speed Civil Transport (HSCT). This technology has been proven for various subsonic vehicles including flight tests on a Navy A-6 and computational application on a Boeing 737. Yet, CC has not been widely accepted for general commercial fixed-wing use but its potential has been extensively investigated for decades in wind tunnels across the globe for application to rotorcraft. More recently, an experimental investigation was performed at Georgia Tech Research Institute (GTRI) with application to an HSCT-type configuration. The data from those experiments was to be applied to a full-scale vehicle to assess the impact from a system level point of view. Hence, this study attempted to quantitatively assess the impact of this technology to an HSCT. The study objective was achieved in three primary steps: 1) Defining the need for CC technology; 2) Wind tunnel data reduction; 3) Detailed takeoff/landing performance assessment. Defining the need for the CC technology application to an HSCT encompassed a preliminary system level analysis. This was accomplished through the utilization of recent developments in modern aircraft design theory at Aerospace Systems Design Laboratory (ASDL). These developments include the creation of techniques and methods needed for the identification of technical feasibility show stoppers. These techniques and methods allow the designer to rapidly assess a design space and disciplinary metric enhancements to enlarge or improve the design space. The takeoff and landing field lengths were identified as the concept "show-stoppers". Once the need for CC was established, the actual application of data and trends was assessed. This assessment entailed a reduction of the wind tunnel data from the experiments performed by Mr. Bob Englar at the GTRI. Relevant data was identified and manipulated based on the required format of the analysis tools utilized. Propulsive, aerodynamic, duct sizing, and vehicle sizing investigations were performed and information supplied to a detailed takeoff and landing tool, From the assessments, CC was shown to improve the low speed performance metrics, which were previously not satisfied. An HSCT with CC augmentation does show potential for full-scale application. Yet, an economic assessment of an HSCT with and without CC showed that a moderate penalty was incurred from the increased RDT&E costs associated with developing the CC technology and slight increases in empty weight.

Using the Gamma-Poisson Model to Predict Library Circulations.

ERIC Educational Resources Information Center

Burrell, Quentin L.

1990-01-01

Argues that the gamma mixture of Poisson processes, for all its perceived defects, can be used to make predictions regarding future library book circulations of a quality adequate for general management requirements. The use of the model is extensively illustrated with data from two academic libraries. (Nine references) (CLB)

Computational Evaluation of the Steady and Pulsed Jet Effects on the Performance of a Circulation Control Wing Section

NASA Technical Reports Server (NTRS)

Liu, Yi; Sankar, Lakshmi N.; Englar, Robert J.; Ahuja, Krishan K.; Gaeta, R.

2005-01-01

Circulation Control technology is a very effective way of achieving high lift forces required by aircraft during take-off and landing. This technology can also directly control the flow field over the wing. Compared to a conventional high-lift system, a Circulation Control Wing (CCW) can generate comparable or higher lift forces during take-off/landing with fewer or no moving parts and much less complexity. In this work, an unsteady three-dimensional Navier-Stokes analysis procedure has been developed and applied to Circulation Control Wing configurations. The effects of 2-D steady jets and 2-D pulsed jets on the aerodynamic performance of CCW airfoils have been investigated. It is found that a steady jet can generate very high lift at zero angle of attack without stall, and that a small amount of blowing can eliminate vortex shedding at the trailing edge, a potential noise source. It is also found that a pulsed jet can achieve the same high lift as a steady jet at lower mass flow rates, especially at a high frequency, and that the Strouhal number has a more dominant effect on the pulsed jet performance than just the frequency or the free-stream velocity.

Application of CFB technology for large power generating units and CO{sub 2} capture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryabov, G. A., E-mail: georgy.ryabov@gmail.com; Folomeev, O. M.; Sankin, D. A.

2010-07-15

Data on the development of the circulating fluidized bed (CFB) technology for combustion of fuels in large power generating units are examined. The problems with raising the steam parameters and unit power of boilers with a circulating fluidized bed are examined. With the boiler system at the 460 MW unit at Lagisza (Poland) as an example, the feasibility of raising the efficiency of units with CFB boilers through deep recovery of the heat of the effluent gases and reducing expenditure for in-house needs is demonstrated. Comparative estimates of the capital and operating costs of 225 and 330 MW units aremore » used to determine the conditions for optimum use of CFB boilers in the engineering renovation of thermal power plants in Russia. New areas for the application of CFB technology in CO{sub 2} capture are analyzed in connection with the problem of reducing greenhouse gas emissions.« less

Fiber-Optic Array Scanning Technology (FAST) for Detection and Molecular Characterization of Circulating Tumor Cells.

PubMed

Ao, Zheng; Liu, Xiaohe

2017-01-01

Circulating tumor cell (CTC) as an important component in "liquid biopsy" holds crucial clinical relevance in cancer prognosis, treatment efficiency evaluation, prediction and potentially early detection. Here, we present a Fiber-optic Array Scanning Technology (FAST) that enables antigen-agnostic, size-agnostic detection of CTC. By immunofluorescence staining detection of a combination of a panel of markers, FAST technology can be applied to detect rare CTC in non-small cell lung cancer (NSCLC) setting with high sensitivity and specificity. In combination with Automated Digital Microscopy (ADM) platform, companion markers on CTC such as Vimentin and Programmed death-ligand 1 (PD-L1) can also be analyzed to further characterize these CTCs. FAST data output is also compatible with downstream single cell picking platforms. Single cell can be isolated post ADM confirmation and used for "actionable" genetic mutations analysis.

NASA tech brief evaluations

NASA Technical Reports Server (NTRS)

Workman, Gary L.

1994-01-01

A major step in transferring technology is to disseminate information about new developments to the appropriate sector(s). A useful vehicle for transferring technology from the government sector to industry has been demonstrated with the use of periodical and journal announcements to highlight technological achievements which may meet the needs of industries other than the one who developed the innovation. To meet this end, NASA has very successfully pursued the goal of identifying technical innovations through the national circulation publication; NASA Tech Briefs. At one time the Technology Utilization Offices of the various centers coordinated the selection of appropriate technologies through a common channel. In recent years, each NASA field center has undertaken the task of evaluating submittals for Tech Brief publication independently of the others. The University of Alabama in Huntsville was selected to assist MSFC in evaluating technology developed under the various programs managed by the NASA center for publication in the NASA Tech Briefs journal. The primary motivation for the NASA Tech Briefs publication is to bring to the attention of industry the various NASA technologies which, in general, have been developed for a specific aerospace requirement, but has application in other areas. Since there are a number of applications outside of NASA that can benefit from innovative concepts developed within the MSPC programs, the ability to transfer technology to other sectors is very high. In most cases, the innovator(s) are not always knowledgeable about other industries which might potentially benefit from their innovation. The evaluation process can therefore contribute to the list of potential users through a knowledgeable evaluator.

Stratospheric Ozone Distribution and Tropospheric General Circulation: Interconnections in the UTLS Region

NASA Astrophysics Data System (ADS)

Barodka, S.; Krasovsky, A.; Shalamyansky, A.

2014-12-01

The height of the tropopause, which divided the stratosphere and the troposphere, is a result of two rival categories of processes: the tropospheric vertical convection and the radiative heating of the stratosphere resulting from the ozone cycle. Hence, it is natural that tropospheric and stratospheric phenomena can have effect each other in manifold processes of stratosphere-troposphere interactions. In the present study we focus our attention to the "top-down" side of the interaction: the impact of stratospheric ozone distribution on the features of tropospheric circulation and the associated weather patterns and regional climate conditions. We proceed from analyzes of the observational data performed at the A.I. Voeikov Main Geophysical Observatory, which suggest a distinct correlation between stratospheric ozone distribution, synoptic formations and air-masses boundaries in the upper troposphere and the temperature field of the lower stratosphere [1]. Furthermore, we analyze local features of atmospheric general circulation and stratospheric ozone distribution from the atmospheric reanalyses and general circulation model data, focusing our attention to instantaneous positions of subtropical and polar stationary atmospheric fronts, which define regional characteristics of the general circulation cells in the troposphere and separate global tropospheric air-masses, correspond to distinct meteorological regimes in the TOC field [2, 3]. We assume that by altering the tropopause height, stratospheric ozone-related processes can have an impact on the location of the stationary atmospheric fronts, thereby exerting influence on circulation processes in troposphere and lower stratosphere. For midlatitudes, the tropopause height controls the position of the polar stationary front, which has a direct impact on the trajectory of motion of active vortices on synoptic tropospheric levels, thereby controlling weather patterns in that region and the regional climate. This mechanism is particularly important for the formation of blocking events. [1] A.M. Shalamyansky - Proceedings of Voeikov Main Geophysical Observatory, V. 568, pp. 173-194, 2013 (in Russian) [2] R.D. Hudson et al - J. Atmos. Sci., V. 60, pp. 1669-1677, 2003. [3] R.D. Hudson et al - Atmos. Chem. Phys., V. 6, pp. 5183-5191, 2006.

Voice Technologies in Libraries: A Look into the Future.

ERIC Educational Resources Information Center

Lange, Holley R., Ed.; And Others

1991-01-01

Discussion of synthesized speech and voice recognition focuses on a forum that addressed the potential for speech technologies in libraries. Topics discussed by three contributors include possible library applications in technical processing, book receipt, circulation control, and database access; use by disabled and illiterate users; and problems…

IM and SMS for the Circulation Desk

ERIC Educational Resources Information Center

Power, June L.

2012-01-01

It's been well documented in a number of articles regarding the contemporary library patron that with the rise in mobile computing and smart phone technology, patrons are looking for fast and easy service from whichever technological avenue they are using to access library services. Libraries are responding with increasing numbers of online…

Studies in the parameterization of cloudiness in climate models and the analysis of radiation fields in general circulation models

NASA Technical Reports Server (NTRS)

HARSHVARDHAN

1990-01-01

Broad-band parameterizations for atmospheric radiative transfer were developed for clear and cloudy skies. These were in the shortwave and longwave regions of the spectrum. These models were compared with other models in an international effort called ICRCCM (Intercomparison of Radiation Codes for Climate Models). The radiation package developed was used for simulations of a General Circulation Model (GCM). A synopsis is provided of the research accomplishments in the two areas separately. Details are available in the published literature.

Equatorial waves in the NCAR stratospheric general circulation model

NASA Technical Reports Server (NTRS)

Boville, B. A.

1985-01-01

Equatorially trapped wave modes are very important in the tropical stratospheric momentum balance. Kelvin waves and mixed Rossby-gravity waves are believed to be responsible for the quasi-biennial oscillation of the zonal winds in the equatorial lower stratosphere. Both Kelvin and mixed Rossby-gravity waves have been identified in observations and in numerical models. Kelvin and mixed Rossby-gravity waves are identified in a general circulation model extending from the surface into the mesosphere and looks at the effect on the waves of lowering the top of the model.

The significance of cloud-radiative forcing to the general circulation on climate time scales - A satellite interpretation

NASA Technical Reports Server (NTRS)

Sohn, Byung-Ju; Smith, Eric A.

1992-01-01

This paper focuses on the role of cloud- and surface-atmosphere forcing on the net radiation balance and their potential impact on the general circulation at climate time scales. The globally averaged cloud-forcing estimates and cloud sensitivity values taken from various recent studies are summarized. It is shown that the net radiative heating over the tropics is principally due to high clouds, while the net cooling in mid- and high latitudes is dominated by low and middle clouds.

Experience with a vectorized general circulation weather model on Star-100

NASA Technical Reports Server (NTRS)

Soll, D. B.; Habra, N. R.; Russell, G. L.

1977-01-01

A version of an atmospheric general circulation model was vectorized to run on a CDC STAR 100. The numerical model was coded and run in two different vector languages, CDC and LRLTRAN. A factor of 10 speed improvement over an IBM 360/95 was realized. Efficient use of the STAR machine required some redesigning of algorithms and logic. This precludes the application of vectorizing compilers on the original scalar code to achieve the same results. Vector languages permit a more natural and efficient formulation for such numerical codes.

Zonally averaged model of dynamics, chemistry and radiation for the atmosphere

NASA Technical Reports Server (NTRS)

Tung, K. K.

1985-01-01

A nongeostrophic theory of zonally averaged circulation is formulated using the nonlinear primitive equations on a sphere, taking advantage of the more direct relationship between the mean meridional circulation and diabatic heating rate which is available in isentropic coordinates. Possible differences between results of nongeostrophic theory and the commonly used geostrophic formulation are discussed concerning: (1) the role of eddy forcing of the diabatic circulation, and (2) the nonlinear nearly inviscid limit vs the geostrophic limit. Problems associated with the traditional Rossby number scaling in quasi-geostrophic formulations are pointed out and an alternate, more general scaling based on the smallness of mean meridional to zonal velocities for a rotating planet is suggested. Such a scaling recovers the geostrophic balanced wind relationship for the mean zonal flow but reveals that the mean meridional velocity is in general ageostrophic.

Numerical simulation of the pairwise interaction of deformable cells during migration in a microchannel

NASA Astrophysics Data System (ADS)

Lan, Hongzhi; Khismatullin, Damir B.

2014-07-01

Leukocytes and other circulating cells deform and move relatively to the channel flow in the lateral and translational directions. Their migratory property is important in immune response, hemostasis, cancer progression, delivery of nutrients, and microfluidic technologies such as cell separation and enrichment, and flow cytometry. Using our three-dimensional computational algorithm for multiphase viscoelastic flow, we have investigated the effect of pairwise interaction on the lateral and translational migration of circulating cells in a microchannel. The numerical simulation data show that when two cells with the same size and small separation distance interact, repulsive interaction take place until they reach the same lateral equilibrium position. During this process, they undergo swapping or passing, depending on the initial separation distance between each other. The threshold value of this distance increases with cell deformation, indicating that the cells experiencing larger deformation are more likely to swap. When a series of closely spaced cells with the same size are considered, they generally undergo damped oscillation in both lateral and translational directions until they reach equilibrium positions where they become evenly distributed in the flow direction (self-assembly phenomenon). A series of cells with a large lateral separation distance could collide repeatedly with each other, eventually crossing the centerline and entering the other side of the channel. For a series of cells with different deformability, more deformable cells, upon impact with less deformable cells, move to an equilibrium position closer to the centerline. The results of our study show that the bulk deformation of circulating cells plays a key role in their migration in a microchannel.

A Survey of Private Ohio Academic Libraries' Physical Processing Practices for Circulating Books.

ERIC Educational Resources Information Center

Factor, Olivia Spaid

Little guidance is given in today's general technical services or cataloging textbooks to assist librarians in making decisions on procedures for the physical preparation of materials prior to placement on the shelves for public access. As small, private academic libraries face automation of circulation, addition of security systems, and debates…

Cost-Effectiveness Analysis of the Automation of a Circulation System.

ERIC Educational Resources Information Center

Mosley, Isobel

A general methodology for cost effectiveness analysis was developed and applied to the Colorado State University library loan desk. The cost effectiveness of the existing semi-automated circulation system was compared with that of a fully manual one, based on the existing manual subsystem. Faculty users' time and computer operating costs were…

Neural Control of the Circulation

ERIC Educational Resources Information Center

Thomas, Gail D.

2011-01-01

The purpose of this brief review is to highlight key concepts about the neural control of the circulation that graduate and medical students should be expected to incorporate into their general knowledge of human physiology. The focus is largely on the sympathetic nerves, which have a dominant role in cardiovascular control due to their effects to…

An Improved Heat Budget Estimation Including Bottom Effects for General Ocean Circulation Models

NASA Technical Reports Server (NTRS)

Carder, Kendall; Warrior, Hari; Otis, Daniel; Chen, R. F.

2001-01-01

This paper studies the effects of the underwater light field on heat-budget calculations of general ocean circulation models for shallow waters. The presence of a bottom significantly alters the estimated heat budget in shallow waters, which affects the corresponding thermal stratification and hence modifies the circulation. Based on the data collected during the COBOP field experiment near the Bahamas, we have used a one-dimensional turbulence closure model to show the influence of the bottom reflection and absorption on the sea surface temperature field. The water depth has an almost one-to-one correlation with the temperature rise. Effects of varying the bottom albedo by replacing the sea grass bed with a coral sand bottom, also has an appreciable effect on the heat budget of the shallow regions. We believe that the differences in the heat budget for the shallow areas will have an influence on the local circulation processes and especially on the evaporative and long-wave heat losses for these areas. The ultimate effects on humidity and cloudiness of the region are expected to be significant as well.

Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring.

PubMed

Chang, Yi; Tolani, Bhairavi; Nie, Xiuhong; Zhi, Xiuyi; Hu, Mu; He, Biao

2017-01-01

Circulating cell-free DNA (cfDNA) released by tumor cells, termed ctDNA, closely reflects the heterogeneity of primary cancers and their metastases. As a noninvasive, real-time monitoring biomarker, ctDNA is a promising tool for detecting driver gene mutations, assessing tumor burden and acquired resistance, and early diagnosis. However, isolation and enrichment of cfDNA is a big challenge due to the high degree of DNA fragmentation and its relatively low abundance in the bloodstream. This review aims to provide insights into the recent technological advances in acquisition of optimal quality cfDNA, the use of preservatives, isolation methods, processing timelines, and detection techniques. It also describes clinical applications of ctDNA in cancer patient management.

A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis.

PubMed

Ko, Jina; Bhagwat, Neha; Yee, Stephanie S; Black, Taylor; Redlinger, Colleen; Romeo, Janae; O'Hara, Mark; Raj, Arjun; Carpenter, Erica L; Stanger, Ben Z; Issadore, David

2017-09-12

The use of microtechnology for the highly selective isolation and sensitive detection of circulating tumor cells has shown enormous promise. One challenge for this technology is that the small feature sizes - which are the key to this technology's performance - can result in low sample throughput and susceptibility to clogging. Additionally, conventional molecular analysis of CTCs often requires cells to be taken off-chip for sample preparation and purification before analysis, leading to the loss of rare cells. To address these challenges, we have developed a microchip platform that combines fast, magnetic micropore based negative immunomagnetic selection (>10 mL h -1 ) with rapid on-chip in situ RNA profiling (>100× faster than conventional RNA labeling). This integrated chip can isolate both rare circulating cells and cell clusters directly from whole blood and allow individual cells to be profiled for multiple RNA cancer biomarkers, achieving sample-to-answer in less than 1 hour for 10 mL of whole blood. To demonstrate the power of this approach, we applied our device to the circulating tumor cell based diagnosis of pancreatic cancer. We used a genetically engineered lineage-labeled mouse model of pancreatic cancer (KPCY) to validate the performance of our chip. We show that in a cohort of patient samples (N = 25) that this device can detect and perform in situ RNA analysis on circulating tumor cells in patients with pancreatic cancer, even in those with extremely sparse CTCs (<1 CTC mL -1 of whole blood).

An analysis of the synoptic and climatological applicability of circulation type classifications for Ireland

NASA Astrophysics Data System (ADS)

Broderick, Ciaran; Fealy, Rowan

2013-04-01

Circulation type classifications (CTCs) compiled as part of the COST733 Action, entitled 'Harmonisation and Application of Weather Type Classifications for European Regions', are examined for their synoptic and climatological applicability to Ireland based on their ability to characterise surface temperature and precipitation. In all 16 different objective classification schemes, representative of four different methodological approaches to circulation typing (optimization algorithms, threshold based methods, eigenvector techniques and leader algorithms) are considered. Several statistical metrics which variously quantify the ability of CTCs to discretize daily data into well-defined homogeneous groups are used to evaluate and compare different approaches to synoptic typing. The records from 14 meteorological stations located across the island of Ireland are used in the study. The results indicate that while it was not possible to identify a single optimum classification or approach to circulation typing - conditional on the location and surface variables considered - a number of general assertions regarding the performance of different schemes can be made. The findings for surface temperature indicate that that those classifications based on predefined thresholds (e.g. Litynski, GrossWetterTypes and original Lamb Weather Type) perform well, as do the Kruizinga and Lund classification schemes. Similarly for precipitation predefined type classifications return high skill scores, as do those classifications derived using some optimization procedure (e.g. SANDRA, Self Organizing Maps and K-Means clustering). For both temperature and precipitation the results generally indicate that the classifications perform best for the winter season - reflecting the closer coupling between large-scale circulation and surface conditions during this period. In contrast to the findings for temperature, spatial patterns in the performance of classifications were more evident for precipitation. In the case of this variable those more westerly synoptic stations open to zonal airflow and less influenced by regional scale forcings generally exhibited a stronger link with large-scale circulation.

Ocean Circulation Modeling for Aquatic Dispersion of Liquid Radioactive Effluents from Nuclear Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Y.G.; Lee, G.B.; Bang, S.Y.

2006-07-01

Recently, three-dimensional models have been used for aquatic dispersion of radioactive effluents in relation to nuclear power plant siting based on the Notice No. 2003-12 'Guideline for investigating and assessing hydrological and aquatic characteristics of nuclear facility site' of the Ministry of Science and Technology (MOST) in Korea. Several nuclear power plants have been under construction or planed, which are Shin-Kori Unit 1 and 2, Shin-Wolsong Unit 1 and 2, and Shin-Ulchin Unit 1 and 2. For assessing the aquatic dispersion of radionuclides released from the above nuclear power plants, it is necessary to know the coastal currents around sitesmore » which are affected by circulation of East Sea. In this study, a three dimensional hydrodynamic model for the circulation of the East Sea of Korea has been developed as the first phase, which is based on the RIAMOM (Research Institute of Applied Mechanics' Ocean Model, Kyushu University, Japan). The model uses the primitive equation with hydrostatic approximation, and uses Arakawa-B grid system horizontally and Z coordinate vertically. Model domain is 126.5 deg. E to 142.5 deg. E of east longitude and 33 deg. N and 52 deg. N of the north latitude. The space of the horizontal grid was 1/12 deg. to longitude and latitude direction and vertical level was divided to 20. This model uses Generalized Arakawa Scheme, Slant Advection, and Mode-Splitting Method. The input data were from JODC (Japan Oceanographic Data Center), KNFRDI (Korea National Fisheries Research and Development Institute), and ECMWF (European Center for Medium-Range Weather Forecasts). The modeling results are in fairly good agreement with schematic patterns of the surface circulation in the East Sea/Japan Sea. The local current model and aquatic dispersion model of the coastal region will be developed as the second phase. The oceanic dispersion experiments will be also carried out by using ARGO Drifter around a nuclear power plant site. (authors)« less

General Circulation Model Simulations of the Annual Cycle of Martian Climate

NASA Astrophysics Data System (ADS)

Wilson, R.; Richardson, M.; Rodin, A.

Observations of the martian atmosphere have revealed a strong annual modulation of global mean atmospheric temperature that has been attributed to the pronounced seasonal asymmetry in solar radiation and the highly variable distribution of aerosol. These observations indicate little interannual variability during the relatively cool aphelion season and considerable variability in the perihelion season that is associated with the episodic occurrence of regional and major dust storms. The atmospheric circulation responds to the evolving spatial distribution of aerosol-induced heating and, in turn, plays a major role in determining the sources, sinks, and transport of radiatively active aerosol. We will present simulations employing the GFDL Mars General Circulation Model (MGCM) that show that aspects of the seasonally evolving climate may be simulated in a self-consistent manner using simple dust source parameterizations that represent the effects of lifting associated with local dust storms, dust devil activity, and other processes. Aerosol transport is accomplished, in large part, by elements of the large-scale circulation such as the Hadley circulation, baroclinic storms, tides, etc. A seasonal cycle of atmospheric opacity and temperature results from the variation in the strength and distribution of dust sources as well as from seasonal variations in the efficiency of atmospheric transport associated with changes in the circulation between solstice and equinox, and between perihelion and aphelion. We examine the efficiency of atmospheric transport of dust lifted along the perimeter of the polar caps to gauge the influence of these storms on the global circulation. We also consider the influence of water, as the formation of water ice clouds on dust nuclei may also affect the vertical distribution of dust and strongly influence the aerosol radiative properties.

Numerical modeling of general circulation, thermohaline structure, and residence time in Gorgan Bay, Iran

NASA Astrophysics Data System (ADS)

Ranjbar, Mohammad Hassan; Hadjizadeh Zaker, Nasser

2018-01-01

Gorgan Bay is a semi-enclosed basin located in the southeast of the Caspian Sea, Iran. The bay is recognized as a resting place for migratory birds as well as a spawning habitat for native fish. However, apparently, no detailed research on its physical processes has previously been conducted. In this study, a 3D coupled hydrodynamic and solute transport model was used to investigate general circulation, thermohaline structure, and residence time in Gorgan Bay. Model outputs were validated against a set of field observations. Bottom friction and attenuation coefficient of light intensity were tuned in order to achieve optimum agreement with the observations. Results revealed that, due to the interaction between bathymetry and prevailing winds, a barotropic double-gyre circulation, dominating the general circulation, existed during all seasons in Gorgan Bay. Furthermore, temperature and salinity fluctuations in the bay were seasonal, due to the seasonal variability of atmospheric fluxes. Results also indicated that under the prevailing winds, the domain-averaged residence time in Gorgan Bay would be approximately 95 days. The rivers discharging into Gorgan Bay are considered as the main sources of nutrients in the bay. Since their mouths are located in the area with a residence time of over 100 days, Gorgan Bay could be at risk of eutrophication; it is necessary to adopt preventive measures against water quality degradation.

E-Books and New Library Service Models: An Analysis of the Impact of E-Book Technology on Academic Libraries.

ERIC Educational Resources Information Center

Jantz, Ronald

2001-01-01

Analyzes the implications of electronic book technology (e-books) on academic libraries. Discusses new business models for publishers, including self-publishing, Internet publishing, and partnerships with libraries as publishers; impact on library services, including cataloging, circulation, and digital preservation; user benefits; standards;…

Effects of Synchronous Web-Based Instruction on Students' Thinking Styles and Creativity

ERIC Educational Resources Information Center

Kuo, Ping-Hong

2016-01-01

Technology and innovation are the power of human civilization. In face of such a changeable era, the rapid development and circulation of information technology has hastened the diversification of society. To cope with the approach of information society, teaching methods should also be changed, as traditional injection education could no longer…

Affinity Versus Label-Free Isolation of Circulating Tumor Cells: Who Wins?

PubMed

Murlidhar, Vasudha; Rivera-Báez, Lianette; Nagrath, Sunitha

2016-09-01

The study of circulating tumor cells (CTCs) has been made possible by many technological advances in their isolation. Their isolation has seen many fronts, but each technology brings forth a new set of challenges to overcome. Microfluidics has been a key player in the capture of CTCs and their downstream analysis, with the aim of shedding light into their clinical application in cancer and metastasis. Researchers have taken diverging paths to isolate such cells from blood, ranging from affinity-based isolation targeting surface antigens expressed on CTCs, to label-free isolation taking advantage of the size differences between CTCs and other blood cells. For both major groups, many microfluidic technologies have reported high sensitivity and specificity for capturing CTCs. However, the question remains as to the superiority among these two isolation techniques, specifically to identify different CTC populations. This review highlights the key aspects of affinity and label-free microfluidic CTC technologies, and discusses which of these two would be the highest benefactor for the study of CTCs. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

JPRS Report, Science & Technology. China: Energy.

DTIC Science & Technology

1992-12-24

desulfurization tech- nology at the present time. The wet method technology accounts for 86 percent of all of the world’s flue gas desulfurization facilities...Limestone-gypsum wet method desulfurization tech- nology Huaneng’s Luohuang Power Plant has already imported two sets of 360MW generator boiler flue gas ...Circulating Fluidized-Bed Technology Development [LinZhaokui, Wang Dun’en, et al; DONGLIGONGCHENG, 15 Oct 92] 27 Selection of Flue

SpaceX Dragon Air Circulation System

NASA Technical Reports Server (NTRS)

Hernandez, Brenda; Piatrovich, Siarhei; Prina, Mauro

2011-01-01

The Dragon capsule is a reusable vehicle being developed by Space Exploration Technologies (SpaceX) that will provide commercial cargo transportation to the International Space Station (ISS). Dragon is designed to be a habitable module while it is berthed to ISS. As such, the Dragon Environmental Control System (ECS) consists of pressure control and pressure equalization, air sampling, fire detection, illumination, and an air circulation system. The air circulation system prevents pockets of stagnant air in Dragon that can be hazardous to the ISS crew. In addition, through the inter-module duct, the air circulation system provides fresh air from ISS into Dragon. To utilize the maximum volume of Dragon for cargo packaging, the Dragon ECS air circulation system is designed around cargo rack optimization. At the same time, the air circulation system is designed to meet the National Aeronautics Space Administration (NASA) inter-module and intra-module ventilation requirements and acoustic requirements. A flight like configuration of the Dragon capsule including the air circulation system was recently assembled for testing to assess the design for inter-module and intra-module ventilation and acoustics. The testing included the Dragon capsule, and flight configuration in the pressure section with cargo racks, lockers, all of the air circulation components, and acoustic treatment. The air circulation test was also used to verify the Computational Fluid Dynamics (CFD) model of the Dragon capsule. The CFD model included the same Dragon internal geometry that was assembled for the test. This paper will describe the Dragon air circulation system design which has been verified by testing the system and with CFD analysis.

Seasonal Overturning Circulation in the Red Sea

NASA Astrophysics Data System (ADS)

Yao, F.; Hoteit, I.; Koehl, A.

2010-12-01

The Red Sea exhibits a distinct seasonal overturning circulation. In winter, a typical two-layer exchange structure, with a fresher inflow from the Gulf of Aden on top of an outflow from the Red Sea, is established. In summer months (June to September) this circulation pattern is changed to a three-layer structure: a surface outflow from the Red Sea on top of a subsurface intrusion of the Gulf of Aden Intermediate Water and a weakened deep outflow. This seasonal variability is studied using a general circulation model, MITgcm, with 6 hourly NCEP atmospheric forcing. The model is able to reproduce the observed seasonal variability very well. The forcing mechanisms of the seasonal variability related to seasonal surface wind stress and buoyancy flux, and water mass transformation processes associated with the seasonal overturning circulation are analyzed and presented.

Decision Support Tool Evaluation Report for General NOAA Oil Modeling Environment(GNOME) Version 2.0

NASA Technical Reports Server (NTRS)

Spruce, Joseph P.; Hall, Callie; Zanoni, Vicki; Blonski, Slawomir; D'Sa, Eurico; Estep, Lee; Holland, Donald; Moore, Roxzana F.; Pagnutti, Mary; Terrie, Gregory

2004-01-01

NASA's Earth Science Applications Directorate evaluated the potential of NASA remote sensing data and modeling products to enhance the General NOAA Oil Modeling Environment (GNOME) decision support tool. NOAA's Office of Response and Restoration (OR&R) Hazardous Materials (HAZMAT) Response Division is interested in enhancing GNOME with near-realtime (NRT) NASA remote sensing products on oceanic winds and ocean circulation. The NASA SeaWinds sea surface wind and Jason-1 sea surface height NRT products have potential, as do sea surface temperature and reflectance products from the Moderate Resolution Imaging Spectroradiometer and sea surface reflectance products from Landsat and the Advanced Spaceborne Thermal Emission and Reflectance Radiometer. HAZMAT is also interested in the Advanced Circulation model and the Ocean General Circulation Model. Certain issues must be considered, including lack of data continuity, marginal data redundancy, and data formatting problems. Spatial resolution is an issue for near-shore GNOME applications. Additional work will be needed to incorporate NASA inputs into GNOME, including verification and validation of data products, algorithms, models, and NRT data.

Study on the key technology of grain logistics tracking system

NASA Astrophysics Data System (ADS)

Zhen, Tong; Ge, Hongyi; Jiang, Yuying; Che, Yi

2010-07-01

In recent year, with the rapid development of GIS technology, more and more programming problems depend on the GIS technology and professional model system. The solution of auxiliary programming problem by using GIS technology, which has become very popular. GIS is an important tool and technology, that captures, stores, analyzes, manages, and presents data that are linked to location. A grain logistics distribution system based on GIS is established, which provides a visualization scheme during the process of grain circulation and supports users making decision and analyzing for grain logistics enterprise.

Tidal flushing and wind driven circulation of Ahe atoll lagoon (Tuamotu Archipelago, French Polynesia) from in situ observations and numerical modelling.

PubMed

Dumas, F; Le Gendre, R; Thomas, Y; Andréfouët, S

2012-01-01

Hydrodynamic functioning and water circulation of the semi-closed deep lagoon of Ahe atoll (Tuamotu Archipelago, French Polynesia) were investigated using 1 year of field data and a 3D hydrodynamical model. Tidal amplitude averaged less than 30 cm, but tide generated very strong currents (2 ms(-1)) in the pass, creating a jet-like circulation that partitioned the lagoon into three residual circulation cells. The pass entirely flushed excess water brought by waves-induced radiation stress. Circulation patterns were computed for climatological meteorological conditions and summarized with stream function and flushing time. Lagoon hydrodynamics and general overturning circulation was driven by wind. Renewal time was 250 days, whereas the e-flushing time yielded a lagoon-wide 80-days average. Tide-driven flush through the pass and wind-driven overturning circulation designate Ahe as a wind-driven, tidally and weakly wave-flushed deep lagoon. The 3D model allows studying pearl oyster larvae dispersal in both realistic and climatological conditions for aquaculture applications. Copyright © 2012 Elsevier Ltd. All rights reserved.

The Sterilization Effect of Cooperative Treatment of High Voltage Electrostatic Field and Variable Frequency Pulsed Electromagnetic Field on Heterotrophic Bacteria in Circulating Cooling Water

NASA Astrophysics Data System (ADS)

Gao, Xuetong; Liu, Zhian; Zhao, Judong

2018-01-01

Compared to other treatment of industrial circulating cooling water in the field of industrial water treatment, high-voltage electrostatic field and variable frequency pulsed electromagnetic field co-sterilization technology, an advanced technology, is widely used because of its special characteristics--low energy consumption, nonpoisonous and environmentally friendly. In order to get a better cooling water sterilization effect under the premise of not polluting the environment, some experiments about sterilization of heterotrophic bacteria in industrial circulating cooling water by cooperative treatment of high voltage electrostatic field and variable frequency pulsed electromagnetic field were carried out. The comparison experiment on the sterilization effect of high-voltage electrostatic field and variable frequency pulsed electromagnetic field co-sterilization on heterotrophic bacteria in industrial circulating cooling water was carried out by change electric field strength and pulse frequency. The results show that the bactericidal rate is selective to the frequency and output voltage, and the heterotrophic bacterium can only kill under the condition of sweep frequency range and output voltage. When the voltage of the high voltage power supply is 4000V, the pulse frequency is 1000Hz and the water temperature is 30°C, the sterilization rate is 48.7%, the sterilization rate is over 90%. Results of this study have important guiding significance for future application of magnetic field sterilization.

Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.

PubMed

Morinaga, Jun; Zhao, Jiabin; Endo, Motoyoshi; Kadomatsu, Tsuyoshi; Miyata, Keishi; Sugizaki, Taichi; Okadome, Yusuke; Tian, Zhe; Horiguchi, Haruki; Miyashita, Kazuya; Maruyama, Nobuhiro; Mukoyama, Masashi; Oike, Yuichi

2018-01-01

Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 reportedly contribute to progression of metabolic disease, a risk factor for cardiovascular disease (CVD). The purpose of this study was to investigate whether circulating ANGPTL levels are associated with CVD risk after adjustment for potential confounding factors. We conducted a single center, cross-sectional study of 988 Japanese subjects undergoing routine health checks. Serum ANGPTL3, 4, and 8 levels were measured using an enzyme-linked immunosorbent assay. Using multiple regression analysis we evaluated potential association of circulating ANGPTL3, 4, and 8 levels with general medical status including age, sex, smoking, drinking, obesity, hypertension, impaired glycometabolism, dyslipidemia, hyperuricemia, hepatic impairment, chronic kidney disease, anemia, cardiac abnormality, and inflammation. Circulating ANGPTL3 levels were relatively high in health-related categories of hepatic impairment and inflammation. Circulating ANGPTL4 levels were also significantly high in impaired glycometabolism or hepatic impairment but decreased in inflammation. Finally, increased ANGPTL8 levels were observed in obesity, impaired glycometabolism and dyslipidemia. Particularly, increased levels of circulating ANGPTL8 were positively correlated with circulating triglycerides and LDL-cholesterol levels and inversely correlated with circulating HDL-cholesterol levels. Circulating ANGPTL3, 4, and 8 levels reflect some risk factors for CVD development.

A simple biosphere model (SiB) for use within general circulation models

NASA Technical Reports Server (NTRS)

Sellers, P. J.; Mintz, Y.; Sud, Y. C.; Dalcher, A.

1986-01-01

A simple realistic biosphere model for calculating the transfer of energy, mass and momentum between the atmosphere and the vegetated surface of the earth has been developed for use in atmospheric general circulation models. The vegetation in each terrestrial model grid is represented by an upper level, representing the perennial canopy of trees and shrubs, and a lower level, representing the annual cover of grasses and other heraceous species. The vegetation morphology and the physical and physiological properties of the vegetation layers determine such properties as: the reflection, transmission, absorption and emission of direct and diffuse radiation; the infiltration, drainage, and storage of the residual rainfall in the soil; and the control over the stomatal functioning. The model, with prescribed vegetation parameters and soil interactive soil moisture, can be used for prediction of the atmospheric circulation and precipitaion fields for short periods of up to a few weeks.

Improved short-term variability in the thermosphere-ionosphere-mesosphere-electrodynamics general circulation model

NASA Astrophysics Data System (ADS)

Häusler, K.; Hagan, M. E.; Baumgaertner, A. J. G.; Maute, A.; Lu, G.; Doornbos, E.; Bruinsma, S.; Forbes, J. M.; Gasperini, F.

2014-08-01

We report on a new source of tidal variability in the National Center for Atmospheric Research thermosphere-ionosphere-mesosphere-electrodynamics general circulation model (TIME-GCM). Lower boundary forcing of the TIME-GCM for a simulation of November-December 2009 based on 3-hourly Modern-Era Retrospective Analysis for Research and Application (MERRA) reanalysis data includes day-to-day variations in both diurnal and semidiurnal tides of tropospheric origin. Comparison with TIME-GCM results from a heretofore standard simulation that includes climatological tropospheric tides from the global-scale wave model reveal evidence of the impacts of MERRA forcing throughout the model domain, including measurable tidal variability in the TIME-GCM upper thermosphere. Additional comparisons with measurements made by the Gravity field and steady-state Ocean Circulation Explorer satellite show improved TIME-GCM capability to capture day-to-day variations in thermospheric density for the November-December 2009 period with the new MERRA lower boundary forcing.

Pacific deep circulation and ventilation controlled by tidal mixing away from the sea bottom.

PubMed

Oka, Akira; Niwa, Yoshihiro

2013-01-01

Vertical mixing in the ocean is a key driver of the global ocean thermohaline circulation, one of the most important factors controlling past and future climate change. Prior observational and theoretical studies have focused on intense tidal mixing near the sea bottom (near-field mixing). However, ocean general circulation models that employ a parameterization of near-field mixing significantly underestimate the strength of the Pacific thermohaline circulation. Here we demonstrate that tidally induced mixing away from the sea bottom (far-field mixing) is essential in controlling the Pacific thermohaline circulation. Via the addition of far-field mixing to a widely used tidal parameterization, we successfully simulate the Pacific thermohaline circulation. We also propose that far-field mixing is indispensable for explaining the presence of the world ocean's oldest water in the eastern North Pacific Ocean. Our findings suggest that far-field mixing controls ventilation of the deep Pacific Ocean, a process important for ocean carbon and biogeochemical cycles.

Multiple states in the late Eocene ocean circulation

NASA Astrophysics Data System (ADS)

Baatsen, M. L. J.; von der Heydt, A. S.; Kliphuis, M.; Viebahn, J.; Dijkstra, H. A.

2018-04-01

The Eocene-Oligocene Transition (EOT) marks a major step within the Cenozoic climate in going from a greenhouse into an icehouse state, with the formation of a continental-scale Antarctic ice sheet. The roles of steadily decreasing CO2 concentrations versus changes in ocean circulation at the EOT are still debated and the threshold for Antarctic glaciation is obscured by uncertainties in global geometry. Here, a detailed study of the late Eocene ocean circulation is carried out using an ocean general circulation model under two slightly different geography reconstructions of the middle-to-late Eocene (38 Ma). Using the same atmospheric forcing, both geographies give a profoundly different equilibrium ocean circulation state. The underlying reason for this sensitivity is the presence of multiple equilibria characterised by either North or South Pacific deep water formation. A possible shift from a southern towards a northern overturning circulation would result in significant changes in the global heat distribution and consequently make the Southern Hemisphere climate more susceptible for significant cooling and ice sheet formation on Antarctica.

Magnetic Flux Circulation During Dawn-Dusk Oriented Interplanetary Magnetic Field

NASA Technical Reports Server (NTRS)

Mitchell, E. J.; Lopez, R. E.; Fok, M.-C.; Deng, Y.; Wiltberger, M.; Lyon, J.

2010-01-01

Magnetic flux circulation is a primary mode of energy transfer from the solar wind into the ionosphere and inner magnetosphere. For southward interplanetary magnetic field (IMF), magnetic flux circulation is described by the Dungey cycle (dayside merging, night side reconnection, and magnetospheric convection), and both the ionosphere and inner magnetosphere receive energy. For dawn-dusk oriented IMF, magnetic flux circulation is not well understood, and the inner magnetosphere does not receive energy. Several models have been suggested for possible reconnection patterns; the general pattern is: dayside merging; reconnection on the dayside or along the dawn/dusk regions; and, return flow on dayside only. These models are consistent with the lack of energy in the inner magnetosphere. We will present evidence that the Dungey cycle does not explain the energy transfer during dawn-dusk oriented IMF. We will also present evidence of how magnetic flux does circulate during dawn-dusk oriented IMF, specifically how the magnetic flux reconnects and circulates back.

The annual cycle of pressure on Mars measured by Viking landers 1 and 2

NASA Technical Reports Server (NTRS)

Hess, S. L.; Ryan, J. A.; Tillman, J. E.; Henry, R. M.; Leovy, C. B.

1980-01-01

Daily mean atmospheric pressures at the two Viking landers are presented for slightly more than a Martian year. The seasonal variation of pressure owing to exchange of CO2 with the polar caps is quite evident and contradicts, in part, earlier theoretical results. Day-to-day variations are the result of passage of synoptic-scale high and low pressure systems and are an important clue to the general circulation of the atmosphere. The effects of global dust storms on the general circulation and on the diurnal variation of pressure are detected and interpreted.

Computational design of the basic dynamical processes of the UCLA general circulation model

NASA Technical Reports Server (NTRS)

Arakawa, A.; Lamb, V. R.

1977-01-01

The 12-layer UCLA general circulation model encompassing troposphere and stratosphere (and superjacent 'sponge layer') is described. Prognostic variables are: surface pressure, horizontal velocity, temperature, water vapor and ozone in each layer, planetary boundary layer (PBL) depth, temperature, moisture and momentum discontinuities at PBL top, ground temperature and water storage, and mass of snow on ground. Selection of space finite-difference schemes for homogeneous incompressible flow, with/without a free surface, nonlinear two-dimensional nondivergent flow, enstrophy conserving schemes, momentum advection schemes, vertical and horizontal difference schemes, and time differencing schemes are discussed.

Maintenance of Summer Monsoon Circulations: A Planetary-Scale Perspective.

NASA Astrophysics Data System (ADS)

Chen, Tsing-Chang

2003-06-01

The monsoon circulation, which is generally considered to be driven by the landmass-ocean thermal contrast, like a gigantic land-sea breeze circulation, exhibits a phase reversal in its vertical structure; a monsoon high aloft over a continental thermal low is juxtaposed with a midoceanic trough underlaid by an oceanic anticyclone. This classic monsoon circulation model is well matched by the monsoon circulation depicted with the observational data prior to the First Global Atmospheric Research Program (GARP) Global Experiment (FGGE). However, synthesizing findings of the global circulation portrayed with the post-FGGE data, it was found that some basic features of major monsoon circulations in Asia, North America, South America, and Australia differ from those of the classic monsoon circulation model. Therefore, a revision of the classic monsoon theory is suggested. With four different wave regimes selected to fit the horizontal dimensions of these monsoon circulations, basic features common to all four major monsoons are illustrated in terms of diagnostic analyses of the velocity potential maintenance equation (which relates diabatic heating and velocity potential) and the streamfunction budget (which links velocity potential and streamfunction) in these wave regimes. It is shown that a monsoon circulation is actually driven by the east-west differential heating and maintained dynamically by a balance between a vorticity source and advection. This dynamic balance is reflected by a spatial quadrature relationship between the monsoon divergent circulation and the monsoon high (low) at upper (lower) levels.

Where Is the “Optimal” Fontan Hemodynamics?

PubMed Central

2017-01-01

Fontan circulation is generally characterized by high central venous pressure, low cardiac output, and slightly low arterial oxygen saturation, and it is quite different from normal biventricular physiology. Therefore, when a patient with congenital heart disease is selected as a candidate for this type of circulation, the ultimate goals of therapy consist of 2 components. One is a smooth adjustment to the new circulation, and the other is long-term circulatory stabilization after adjustment. When either of these goals is not achieved, the patient is categorized as having “failed” Fontan circulation, and the prognosis is dismal. For the first goal of smooth adjustment, a lot of effort has been made to establish criteria for patient selection and intensive management immediately after the Fontan operation. For the second goal of long-term circulatory stabilization, there is limited evidence of successful strategies for long-term hemodynamic stabilization. Furthermore, there have been no data on optimal hemodynamics in Fontan circulation that could be used as a reference for patient management. Although small clinical trials and case reports are available, the results cannot be generalized to the majority of Fontan survivors. We recently reported the clinical and hemodynamic characteristics of early and late failing Fontan survivors and their association with all-cause mortality. This knowledge could provide insight into the complex Fontan pathophysiology and might help establish a management strategy for long-term hemodynamic stabilization. PMID:29035429

Label-free isolation of circulating tumor cells in microfluidic devices: Current research and perspectives.

PubMed

Cima, Igor; Wen Yee, Chay; Iliescu, Florina S; Phyo, Wai Min; Lim, Kiat Hon; Iliescu, Ciprian; Tan, Min Han

2013-01-01

This review will cover the recent advances in label-free approaches to isolate and manipulate circulating tumor cells (CTCs). In essence, label-free approaches do not rely on antibodies or biological markers for labeling the cells of interest, but enrich them using the differential physical properties intrinsic to cancer and blood cells. We will discuss technologies that isolate cells based on their biomechanical and electrical properties. Label-free approaches to analyze CTCs have been recently invoked as a valid alternative to "marker-based" techniques, because classical epithelial and tumor markers are lost on some CTC populations and there is no comprehensive phenotypic definition for CTCs. We will highlight the advantages and drawbacks of these technologies and the status on their implementation in the clinics.

A New Dry Flue Gas Desulfurization Process-Underfeed Circulating Spouted Bed

NASA Astrophysics Data System (ADS)

Tao, M.; Jin, B. S.; Yang, Y. P.

Applying an underfeed system, the underfeed circulating spouted bed was designed as a desulfurization reactor. The main objective of the technology is to improve the mixing effect and distribution uniformity of solid particles, and therefore to advance the desulfurization efficiency and calcium utility. In this article, a series of experimental studies were conducted to investigate the fluidization behavior of the solid-gas two-phase flow in the riser. The results show that the technology can distinctly improve the distribution of gas velocity and particle flux on sections compared with the facefeed style. Analysis of pressure fluctuation signals indicates that the operation parameters have significant influence on the flow field in the reaction bed. The existence of injecting flow near the underfeed nozzle has an evident effect on strengthening the particle mixing.

Design and Fabrication of Millimeter Wave Hexagonal Nano-Ferrite Circulator on Silicon CMOS Substrate

NASA Astrophysics Data System (ADS)

Oukacha, Hassan

The rapid advancement of Complementary Metal Oxide Semiconductor (CMOS) technology has formed the backbone of the modern computing revolution enabling the development of computationally intensive electronic devices that are smaller, faster, less expensive, and consume less power. This well-established technology has transformed the mobile computing and communications industries by providing high levels of system integration on a single substrate, high reliability and low manufacturing cost. The driving force behind this computing revolution is the scaling of semiconductor devices to smaller geometries which has resulted in faster switching speeds and the promise of replacing traditional, bulky radio frequency (RF) components with miniaturized devices. Such devices play an important role in our society enabling ubiquitous computing and on-demand data access. This thesis presents the design and development of a magnetic circulator component in a standard 180 nm CMOS process. The design approach involves integration of nanoscale ferrite materials on a CMOS chip to avoid using bulky magnetic materials employed in conventional circulators. This device constitutes the next generation broadband millimeter-wave circulator integrated in CMOS using ferrite materials operating in the 60GHz frequency band. The unlicensed ultra-high frequency spectrum around 60GHz offers many benefits: very high immunity to interference, high security, and frequency re-use. Results of both simulations and measurements are presented in this thesis. The presented results show the benefits of this technique and the potential that it has in incorporating a complete system-on-chip (SoC) that includes low noise amplifier, power amplier, and antenna. This system-on-chip can be used in the same applications where the conventional circulator has been employed, including communication systems, radar systems, navigation and air traffic control, and military equipment. This set of applications of circulator shows how crucial this device is to many industries and the need for smaller, cost effective RF components.

Interactions Between the Thermohaline Circulation and Tropical Atlantic SST in a Coupled General Circulation Model

NASA Technical Reports Server (NTRS)

Miller, Ron; Jiang, Xing-Jian; Travis, Larry (Technical Monitor)

2001-01-01

Tropical Atlantic SST shows a (statistically well-defined) decadal time scale in a 104-year simulation of unforced variability by a coupled general circulation model (CGCM). The SST anomalies superficially resemble observed Tropical Atlantic variability (TAV), and are associated with changes in the atmospheric circulation. Brazilian rainfall is modulated with a decadal time scale, along with the strength of the Atlantic trade winds, which are associated with variations in evaporation and the net surface heat flux. However, in contrast to observed tropical Atlantic variability, the trade winds damp the associated anomalies in ocean temperature, indicating a negative feedback. Tropical SST anomalies in the CGCM, though opposed by the surface heat flux, are advected in from the Southern Hemisphere mid-latitudes. These variations modulate the strength of the thermohaline circulation (THC): warm, salty anomalies at the equator sink drawing cold, fresh mid-latitude water. Upon reaching the equator, the latter inhibit vertical overturning and advection from higher latitudes, which allows warm, salty anomalies to reform, returning the cycle to its original state. Thus, the cycle results from advection of density anomalies and the effect of these anomalies upon the rate of vertical overturning and surface advection. This decadal modulation of Tropical Atlantic SST and the thermohaline circulation is correlated with ocean heat transport to the Northern Hemisphere high latitudes and Norwegian Sea SST. Because of the central role of equatorial convection, we question whether this mechanism is present in the current climate, although we speculate that it may have operated in palaeo times, depending upon the stability of the tropical water column.

Selective phenol methylation to 2,6-dimethylphenol in a fluidized bed of iron-chromium mixed oxide catalyst with o-cresol circulation.

PubMed

Zukowski, Witold; Berkowicz, Gabriela; Baron, Jerzy; Kandefer, Stanisław; Jamanek, Dariusz; Szarlik, Stefan; Wielgosz, Zbigniew; Zielecka, Maria

2014-01-01

2,6-dimethylphenol (2,6-DMP) is a product of phenol methylation, especially important for the plastics industry. The process of phenol methylation in the gas phase is strongly exothermic. In order to ensure good temperature equalization in the catalyst bed, the process was carried out using a catalyst in the form of a fluidized bed - in particular, the commercial iron-chromium catalyst TZC-3/1. Synthesis of 2,6-dimethylphenol from phenol and methanol in fluidized bed of iron-chromium catalyst was carried out and the fluidization of the catalyst was examined. Stable state of fluidized bed of iron-chromium catalyst was achieved. The measured velocities allowed to determine the minimum flow of reactants, ensuring introduction of the catalyst bed in the reactor into the state of fluidization. Due to a high content of o-cresol in products of 2,6-dimethylphenol synthesis, circulation in the technological node was proposed. A series of syntheses with variable amount of o-cresol in the feedstock allowed to determine the parameters of stationary states. A stable work of technological node with o-cresol circulation is possible in the temperature range of350-380°C, and o-cresolin/phenolin molar ratio of more than 0.48. Synthesis of 2,6-DMP over the iron-chromium catalyst is characterized by more than 90% degree of phenol conversion. Moreover, the O-alkylation did not occur (which was confirmed by GC-MS analysis). By applying o-cresol circulation in the 2,6-DMP process, selectivity of more than 85% degree of 2,6-DMP was achieved. The participation levels of by-products: 2,4-DMP and 2,4,6-TMP were low. In the optimal conditions based on the highest yield of 2,6-DMP achieved in the technological node applying o-cresol circulation, there are 2%mol. of 2,4-DMP and 6%mol. of 2,4,6-TMP in the final mixture, whereas 2,4,6-TMP can be useful as a chain stopper and polymer's molar mass regulator during the polymerization of 2,6-DMP.

Linguistic Layering: Social Language Development in the Context of Multimodal Design and Digital Technologies

ERIC Educational Resources Information Center

Domingo, Myrrh

2012-01-01

In our contemporary society, digital texts circulate more readily and extend beyond page-bound formats to include interactive representations such as online newsprint with hyperlinks to audio and video files. This is to say that multimodality combined with digital technologies extends grammar to include voice, visual, and music, among other modes…

Application of the solid phase C1q and Raji cell radioimmune assays for the detection of circulating immune complexes in glomerulonephritis.

PubMed Central

Tung, K S; Woodroffe, A J; Ahlin, T D; Williams, R C; Wilson, C B

1978-01-01

The C1q solid phase and Raji cell radioimmune assays were used to determine the frequency of detectable circulating immune complexes in patients with glomerulonephritis. In this study, 46% of 56 patients with glomerulonephritis had evidence of circulating immune complexes. More important, circulating immune complexes were associated with some, but not other, types of glomerulonephritis. Thus, immune complexes were detected in lupus glomerulonephritis (9/9 patients), rapidly progressive glomerulonephritis (5/6 patients), and acute nephritis (5/6 patients), but not in IgA-IgG glomerulonephritis (0/7 patients), or membranous glomerulonephritis (0/8 patients). The Raji cell radioimmune assay and the C1q solid phase radioimmune assay showed concordance of 79% in the detection of circulating immune complexes. Serial determinations, in general, showed either persistence of a negative or positive result of conversion of positive to negative. PMID:659639

A dehydration mechanism for the stratosphere

NASA Technical Reports Server (NTRS)

Danielsen, E. F.

1982-01-01

Although mean circulations are generally credited with dehydration of the earth's stratosphere, convective instability in the tropics converts mean circulations to small residuals of local convective circulations. The effects of large cumulonimbus which penetrate the stratosphere and form huge anvils in the lower stratosphere are discussed with respect to hydration and dehydration of the stratosphere. Radiative heating at anvil base combined with cooling at anvil top drives a dehydration engine considered essential to explain the dry stratosphere. Seasonal and longitudinal variations in dehydration potentials are examined with maximum potential attributed to Micronesian area during winter and early spring.

Numerical Simulation in a Supercirtical CFB Boiler

NASA Astrophysics Data System (ADS)

Zhang, Yanjun; Gaol, Xiang; Luo, Zhongyang; Jiang, Xiaoguo

The dimension of the hot circulation loop of the supercritical CFB boiler is large, and there are many unknowns and challenges that should be identified and resolved during the development. In order to realize a reasonable and reliable design of the hot circulation loop, numerical simulation of gas-solid flow in a supercritical CFB boiler was conducted by using FLUENT software. The working condition of hot circulation loop flow field, gas-solid flow affected by three unsymmetrical cyclones, air distribution and pressure drop in furnace were analyzed. The simulation results showed that the general arrangement of the 600MWe supercritical CFB boiler is reasonable.

Parathyroid hormone - Secretion and metabolism in vivo.

NASA Technical Reports Server (NTRS)

Habener, J. F.; Powell, D.; Murray, T. M.; Mayer, G. P.; Potts, J. T., Jr.

1971-01-01

Gel filtration and radioimmunoassay were used to determine the molecular size and immunochemical reactivity of parathyroid hormone present in gland extracts, in the general peripheral circulation, and in parathyroid effluent blood from patients with hyperparathyroidism, as well as from calves and from cattle. It was found that parathyroid hormone secreted from the parathyroids in man and cattle is at least as large as the molecule extracted from normal bovine glands. However, once secreted into the circulation the hormone is cleaved, and one or more fragments, immunologically, dissimilar to the originally secreted hormone, constitute the dominant form of circulating immunoreactive hormone.

The response of an ocean general circulation model to surface wind stress produced by an atmospheric general circulation model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, B.; Schneider, E.K.

1995-10-01

Two surface wind stress datasets for 1979-91, one based on observations and the other from an investigation of the COLA atmospheric general circulation model (AGCM) with prescribed SST, are used to drive the GFDL ocean general circulation model. These two runs are referred to as the control and COLA experiments, respectively. Simulated SST and upper-ocean heat contents (HC) in the tropical Pacific Ocean are compared with observations and between experiments. Both simulation reproduced the observed mean SST and HC fields as well as their annual cycles realistically. Major errors common to both runs are colder than observed SST in themore » eastern equatorial ocean and HC in the western Pacific south of the equator, with errors generally larger in the COLA experiment. New errors arising from the AGCM wind forcing include higher SST near the South American coast throughout the year and weaker HC gradients along the equator in boreal spring. The former is associated with suppressed coastal upwelling by weak along shore AGCM winds, and the latter is caused by weaker equatorial easterlies in boreal spring. The low-frequency ENSO fluctuations are also realistic for both runs. Correlations between the observed and simulated SST anomalies from the COLA simulation are as high as those from the control run in the central equatorial Pacific. A major problem in the COLA simulation is the appearance of unrealistic tropical cold anomalies during the boreal spring of mature El Nino years. These anomalies propagate along the equator from the western Pacific to the eastern coast in about three months, and temporarily eliminate the warm SST and HC anomalies in the eastern Pacific. This erroneous oceanic response in the COLA simulation is caused by a reversal of the westerly wind anomalies on the equator, associated with an unrealistic southward shift of the ITCZ in boreal spring during El Nino events. 66 refs., 16 figs.« less

A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis.

PubMed

Vafaee, Fatemeh; Diakos, Connie; Kirschner, Michaela B; Reid, Glen; Michael, Michael Z; Horvath, Lisa G; Alinejad-Rokny, Hamid; Cheng, Zhangkai Jason; Kuncic, Zdenka; Clarke, Stephen

2018-01-01

Recent advances in high-throughput technologies have provided an unprecedented opportunity to identify molecular markers of disease processes. This plethora of complex-omics data has simultaneously complicated the problem of extracting meaningful molecular signatures and opened up new opportunities for more sophisticated integrative and holistic approaches. In this era, effective integration of data-driven and knowledge-based approaches for biomarker identification has been recognised as key to improving the identification of high-performance biomarkers, and necessary for translational applications. Here, we have evaluated the role of circulating microRNA as a means of predicting the prognosis of patients with colorectal cancer, which is the second leading cause of cancer-related death worldwide. We have developed a multi-objective optimisation method that effectively integrates a data-driven approach with the knowledge obtained from the microRNA-mediated regulatory network to identify robust plasma microRNA signatures which are reliable in terms of predictive power as well as functional relevance. The proposed multi-objective framework has the capacity to adjust for conflicting biomarker objectives and to incorporate heterogeneous information facilitating systems approaches to biomarker discovery. We have found a prognostic signature of colorectal cancer comprising 11 circulating microRNAs. The identified signature predicts the patients' survival outcome and targets pathways underlying colorectal cancer progression. The altered expression of the identified microRNAs was confirmed in an independent public data set of plasma samples of patients in early stage vs advanced colorectal cancer. Furthermore, the generality of the proposed method was demonstrated across three publicly available miRNA data sets associated with biomarker studies in other diseases.

The Sensitivity of the Midlatitude Moist Isentropic Circulation on Both Sides of the Climate Model Hierarchy

NASA Astrophysics Data System (ADS)

Fajber, R. A.; Kushner, P. J.; Laliberte, F. B.

2017-12-01

In the midlatitude atmosphere, baroclinic eddies are able to raise warm, moist air from the surface into the midtroposphere where it condenses and warms the atmosphere through latent heating. This coupling between dynamics and moist thermodynamics motivates using a conserved moist thermodynamic variable, such as the equivalent potential temperature, to study the midlatitude circulation and associated heat transport since it implicitly accounts for latent heating. When the equivalent potential temperature is used to zonally average the circulation, the moist isentropic circulation takes the form of a single cell in each hemisphere. By utilising the statistical transformed Eulerian mean (STEM) circulation we are able to parametrize the moist isentropic circulation in terms of second order dynamic and moist thermodynamic statistics. The functional dependence of the STEM allows us to analytically calculate functional derivatives that reveal the spatially varying sensitivity of the moist isentropic circulation to perturbations in different statistics. Using the STEM functional derivatives as sensitivity kernels we interpret changes in the moist isentropic circulation from two experiments: surface heating in an idealised moist model, and a climate change scenario in a comprehensive atmospheric general circulation model. In both cases we find that the changes in the moist isentropic circulation are well predicted by the functional sensitivities, and that the total heat transport is more sensitive to changes in dynamical processes driving local changes in poleward heat transport than it is to thermodynamic and/or radiative processes driving changes to the distribution of equivalent potential temperature.

Re-recognizing serological change patterns and antiviral therapy opportunity of patients with acute hepatitis B through highly sensitive detection technology.

PubMed

Ma, Haixia; Gao, Min; Li, Jia; Zhou, Li; Guo, Jie; Liu, Junjuan; Han, Xu; Zhai, Lu; Wu, Ting

2016-11-01

This study was conducted to re-recognize serological change patterns of patients with acute hepatitis B (AHB) by a highly sensitive detection technology, as well as to explore methods to select the optimal treatment opportunity. The biochemical and virological parameters of 558 AHB patients were analyzed retrospectively. The serological markers of hepatitis B virus and HBV DNA were detected by electrochemiluminescence immunoassay and automatic real-time fluorescent quantitative PCR, respectively. At baseline, the positive rate of hepatitis B surface antigen (HBsAg) (86.2%) was significantly higher than the positive rate of HBV DNA (51.9%). Among the 58 patients with HBsAg-negative AHB, 16 were detected with trace amounts of HBV DNA at baseline. At 12 weeks, the HBsAg of 43 cases remained positive, and the mean level of HBsAg was 587.5IU/mL±313.4IU/mL. A total of 18 patients with HBsAg levels greater than 1500IU/mL at 12 weeks received interferon α-1b treatment and achieved HBsAg clearance within 24 weeks. Unlike traditional changing patterns, the clearance of HBV DNA in peripheral circulation for a few patients with AHB occurred later than HBsAg clearance. Detection of HBV DNA in peripheral circulation by highly sensitive detection technology could provide a diagnostic basis for those AHB patients who rapidly achieved HBsAg clearance before achieving HBV DNA clearance in their peripheral circulation and prevent misdiagnosis. Dynamic monitoring of the changes in HBsAg levels through highly sensitive detection technology could be used as a guide for the timely adoption of antiviral treatment with interferon and then AHB chronicity would be prevented. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Optimisation of a parallel ocean general circulation model

NASA Astrophysics Data System (ADS)

Beare, M. I.; Stevens, D. P.

1997-10-01

This paper presents the development of a general-purpose parallel ocean circulation model, for use on a wide range of computer platforms, from traditional scalar machines to workstation clusters and massively parallel processors. Parallelism is provided, as a modular option, via high-level message-passing routines, thus hiding the technical intricacies from the user. An initial implementation highlights that the parallel efficiency of the model is adversely affected by a number of factors, for which optimisations are discussed and implemented. The resulting ocean code is portable and, in particular, allows science to be achieved on local workstations that could otherwise only be undertaken on state-of-the-art supercomputers.

Martian aeolian features and deposits - Comparisons with general circulation model results

NASA Astrophysics Data System (ADS)

Greeley, R.; Skypeck, A.; Pollack, J. B.

1993-02-01

The relationships between near-surface winds and the distribution of wind-related features are investigated by means of a general circulation model of Mars' atmosphere. Predictions of wind surface stress as a function of season and dust optical depth are used to investigate the distribution and orientation of wind streaks, yardangs, and rock abundance on the surface. The global distribution of rocks on the surface correlates well with predicted wind stress, particularly during the dust storm season. The rocky areas are sites of strong winds, suggesting that fine material is swept away by the wind, leaving rocks and coarser material behind.

Tropical disturbances in relation to general circulation modeling

NASA Technical Reports Server (NTRS)

Estoque, M. A.

1982-01-01

The initial results of an evaluation of the performance of the Goddard Laboratory of Atmospheric Simulation general circulation model depicting the tropical atmosphere during the summer are presented. Because the results show the existence of tropical wave disturbances throughout the tropics, the characteristics of synoptic disturbances over Africa were studied and a synoptic case study of a selected disturbance in this area was conducted. It is shown that the model is able to reproduce wave type synoptic disturbances in the tropics. The findings show that, in one of the summers simulated, the disturbances are predominantly closed vortices; in another summer, the predominant disturbances are open waves.

Incoming Shortwave Fluxes at the Surface--A Comparison of GCM Results with Observations.

NASA Astrophysics Data System (ADS)

Garratt, J. R.

1994-01-01

Evidence is presented that the exam surface net radiation calculated in general circulation models at continental surfaces is mostly due to excess incoming shortwave fluxes. Based on long-term observations from 22 worldwide inland stations and results from four general circulation models the overestimate in models of 20% (11 W m2) in net radiation on an annual basis compares with 6% (9 W m2) for shortwave fluxes for the same 22 locations, or 9% (18 W m2) for a larger set of 93 stations (71 having shortwave fluxes only). For annual fluxes, these differences appear to be significant.

Ensemble-Based Parameter Estimation in a Coupled General Circulation Model

DOE PAGES

Liu, Y.; Liu, Z.; Zhang, S.; ...

2014-09-10

Parameter estimation provides a potentially powerful approach to reduce model bias for complex climate models. Here, in a twin experiment framework, the authors perform the first parameter estimation in a fully coupled ocean–atmosphere general circulation model using an ensemble coupled data assimilation system facilitated with parameter estimation. The authors first perform single-parameter estimation and then multiple-parameter estimation. In the case of the single-parameter estimation, the error of the parameter [solar penetration depth (SPD)] is reduced by over 90% after ~40 years of assimilation of the conventional observations of monthly sea surface temperature (SST) and salinity (SSS). The results of multiple-parametermore » estimation are less reliable than those of single-parameter estimation when only the monthly SST and SSS are assimilated. Assimilating additional observations of atmospheric data of temperature and wind improves the reliability of multiple-parameter estimation. The errors of the parameters are reduced by 90% in ~8 years of assimilation. Finally, the improved parameters also improve the model climatology. With the optimized parameters, the bias of the climatology of SST is reduced by ~90%. Altogether, this study suggests the feasibility of ensemble-based parameter estimation in a fully coupled general circulation model.« less

Debunking the Computer Science Digital Library: Lessons Learned in Collection Development at Seneca College of Applied Arts & Technology

ERIC Educational Resources Information Center

Buczynski, James Andrew

2005-01-01

Developing a library collection to support the curriculum of Canada's largest computer studies school has debunked many myths about collecting computer science and technology information resources. Computer science students are among the heaviest print book and e-book users in the library. Circulation statistics indicate that the demand for print…

Brushless dc motors. [applications in non-space technology

NASA Technical Reports Server (NTRS)

1975-01-01

Brushless dc motors were intensively developed and tested over several years before qualification as the prime movers for Apollo Spacecraft life support blowers, and for circulating oxygen in the lunar portable life support system. Knowledge gained through prototype development and critical testing has significantly influenced the technology employed, broadened markets and applications, and reduced the cost of present day motors.

Offering More than Just Casebooks: Law Libraries and the Decision to Circulate Mobile Tablets and E-Readers

ERIC Educational Resources Information Center

Le, Avery

2013-01-01

Libraries today are determined to meet the expanding needs of their patrons by keeping their services and book collections up-to-date with the rapidly growing technological advances. Many have adapted to the innovative changes seamlessly by integrating new technology trends such as: (1) purchasing more ebook titles; (2) using social media sites…

Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters.

PubMed

Bithi, Swastika S; Vanapalli, Siva A

2017-02-02

Drug assays with patient-derived cells such as circulating tumor cells requires manipulating small sample volumes without loss of rare disease-causing cells. Here, we report an effective technology for isolating and analyzing individual tumor cells and their clusters from minute sample volumes using an optimized microfluidic device integrated with pipettes. The method involves using hand pipetting to create an array of cell-laden nanoliter-sized droplets immobilized in a microfluidic device without loss of tumor cells during the pipetting process. Using this technology, we demonstrate single-cell analysis of tumor cell response to the chemotherapy drug doxorubicin. We find that even though individual tumor cells display diverse uptake profiles of the drug, the onset of apoptosis is determined by accumulation of a critical intracellular concentration of doxorubicin. Experiments with clusters of tumor cells compartmentalized in microfluidic drops reveal that cells within a cluster have higher viability than their single-cell counterparts when exposed to doxorubicin. This result suggests that circulating tumor cell clusters might be able to better survive chemotherapy drug treatment. Our technology is a promising tool for understanding tumor cell-drug interactions in patient-derived samples including rare cells.

Quantifying predictability variations in a low-order ocean-atmosphere model - A dynamical systems approach

NASA Technical Reports Server (NTRS)

Nese, Jon M.; Dutton, John A.

1993-01-01

The predictability of the weather and climatic states of a low-order moist general circulation model is quantified using a dynamic systems approach, and the effect of incorporating a simple oceanic circulation on predictability is evaluated. The predictability and the structure of the model attractors are compared using Liapunov exponents, local divergence rates, and the correlation and Liapunov dimensions. It was found that the activation of oceanic circulation increases the average error doubling time of the atmosphere and the coupled ocean-atmosphere system by 10 percent and decreases the variance of the largest local divergence rate by 20 percent. When an oceanic circulation develops, the average predictability of annually averaged states is improved by 25 percent and the variance of the largest local divergence rate decreases by 25 percent.

Modeling of subaqueous melting in Petermann Fjord, Northwestern Greenland using an ocean general circulation model

NASA Astrophysics Data System (ADS)

Cai, C.; Rignot, E. J.; Xu, Y.; An, L.; Tinto, K. J.; van den Broeke, M. R.

2014-12-01

Basal melting of the floating tongue of Petermann Glacier, in northwestern Greenland is by far the largest process of mass ablation. Melting of the floating tongue is controlled by the buoyancy of the melt water plume, the pressure-dependence of the melting point of sea ice, and the mixing of warm subsurface water with fresh buoyant subglacial discharge. In prior simulations of this melting process, the role of subglacial discharge has been neglected because in similar configurations (floating ice shelves) in the Antarctic, surface runoff is negligible; this is however not true in Greenland. Here, we use the Mass Institute of Technology general circulation model (MITgcm) at a high spatial resolution (10 m x 10 m) to simulate the melting process of the ice shelf in 2-D. The model is constrained by ice shelf bathymetry and ice thickness (refined model in the immediate vicinity of the grounding line) from NASA Operation IceBridge (2011), ocean temperature/salinity data from Johnson et al. (2011), ocean tide height and current from the Arctic Ocean Tidal Inverse Model (AOTIM-5) by Padman and Erofeeva (2004) and subglacial discharge at the grounding line calculated by the hydrostatic potential of the ice from estimated products of the Regional Atmospheric Climate Model (RACMO) of Royal Netherlands Meteorological Institute (KNMI). We compare the results obtained in winter (no runoff) with summer, and the sensitivity of the results to thermal forcing from the ocean, and to the variation of tide height and current, and to the magnitude of subglacial runoff. We conclude on the impact of the ocean and surface melting on the melting regime of the floating ice tongue of Petermann. The basal melt rate increases ~20% with summer surface runoff. This work is performed under a contract with NASA Cryosphere Program.

Recent intensification of the Walker Circulation and the role of natural sea surface temperature variability

NASA Astrophysics Data System (ADS)

Zhao, X.; Allen, R.

2017-12-01

In a warming world, the tropical atmospheric overturning circulation-including the Walker Circulation-is expected to weaken due to thermodynamic constraints. Tropical precipitation increases at a slower rate than water vapor-which increases according to Clausius Clapeyron scaling, assuming constant relative humidity-so the tropical overturning circulation slows down. This is supported by both observations and model simulations, which show a slowdown of the Walker Circulation over the 20th century. Model projections suggest a further weakening of the Walker Circulation in the 21st century. However, over the last several decades (1979-2014), multiple observations reveal a robust strengthening of the Walker Circulation. Although coupled CMIP5 simulations are unable to reproduce this strengthening, AMIP simulations-which feature the observed evolution of SSTs-are generally able to reproduce it. Assuming the ensemble mean sea surface temperatures (SSTs) from historical CMIP5 simulations accurately represent the externally forced SST response, the observed SSTs can be decomposed into a forced and an unforced component. CAM5 AMIP-type simulations driven by the unforced component of observed SSTs reproduce the observed strengthening of the Walker Circulation. Corresponding simulations driven by the forced component of observed SSTs yield a weaker Walker Circulation. These results are consistent with the zonal tropical SST gradient and the Bjerknes feedback. The unforced component of SSTs yield an increased SST gradient over tropical Pacific (a La Nina like pattern) and strengthening of the tropical trade winds, which constitute the lower branch of the Walker Circulation. The forced component of SSTs yields a zonally uniform tropical Pacific SST warming and a marginal weakening of the Walker Circulation. Our results suggest significant modulation of the tropical Walker Circulation by natural SST variability over the last several decades.

Large-Scale Atmosphere-Ocean Coupling.

DTIC Science & Technology

1984-05-01

connection. between Pacific tropical diabatic heating anomalies and extratropical circulation system over the North Pacific from East Asia to the...and G. J. Boer, 1972: REFERENCES The General Circulation of the Tropical Atmosphere and Interaction with Extratropical Latitudes. Vol. 1. MIT Press...implications for the development of severe convective storms . Mom. We& Rev.. Chang, C.-P., and K. M. Lau, 1980: Northeasterly cold surges 167, 682-703. and

Documentation of a ground hydrology parameterization for use in the GISS atmospheric general circulation model

NASA Technical Reports Server (NTRS)

Lin, J. D.; Aleano, J.; Bock, P.

1978-01-01

The moisture transport processes related to the earth's surface relevant to the ground circulation model GCM are presented. The GHM parametrizations considered are: (1) ground wetness and soil parameters; (2) precipitation; (3) evapotranspiration; (4) surface storage of snow and ice; and (5) runout. The computational aspects of the GHM using computer programs and flow charts are described.

Library Computing.

ERIC Educational Resources Information Center

Library Journal, 1985

1985-01-01

This special supplement to "Library Journal" and "School Library Journal" includes articles on technological dependency, promise of computers for reluctant readers, copyright and database downloading, access to neighborhood of Mister Rogers, library acquisitions, circulating personal computers, "microcomputeritis,"…

Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications

PubMed Central

Harouaka, Ramdane; Kang, Zhigang; Zheng, Siyang; Cao, Liang

2013-01-01

Circulating tumor cells (CTCs) are rare cancer cells released from tumors into the bloodstream that are thought to have a key role in cancer metastasis. The presence of CTCs has been associated with worse prognosis in several major cancer types, including breast, prostate and colorectal cancer. There is considerable interest in CTC research and technologies for their potential use as cancer biomarkers that may enhance cancer diagnosis and prognosis, facilitate drug development, and improve the treatment of cancer patients. This review provides an update on recent progress in CTC isolation and molecular characterization technologies. Furthermore, the review covers significant advances and limitations in the clinical applications of CTC-based assays for cancer prognosis, response to anti-cancer therapies, and exploratory studies in biomarkers predictive of sensitivity and resistance to cancer therapies. PMID:24134902

Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications.

PubMed

Harouaka, Ramdane; Kang, Zhigang; Zheng, Si-Yang; Cao, Liang

2014-02-01

Circulating tumor cells (CTCs) are rare cancer cells released from tumors into the bloodstream that are thought to have a key role in cancer metastasis. The presence of CTCs has been associated with worse prognosis in several major cancer types, including breast, prostate and colorectal cancer. There is considerable interest in CTC research and technologies for their potential use as cancer biomarkers that may enhance cancer diagnosis and prognosis, facilitate drug development, and improve the treatment of cancer patients. This review provides an update on recent progress in CTC isolation and molecular characterization technologies. Furthermore, the review covers significant advances and limitations in the clinical applications of CTC-based assays for cancer prognosis, response to anti-cancer therapies, and exploratory studies in biomarkers predictive of sensitivity and resistance to cancer therapies. Published by Elsevier Inc.

Global and European climate impacts of a slowdown of the AMOC in a high resolution GCM

NASA Astrophysics Data System (ADS)

Jackson, L. C.; Kahana, R.; Graham, T.; Ringer, M. A.; Woollings, T.; Mecking, J. V.; Wood, R. A.

2015-12-01

The impacts of a hypothetical slowdown in the Atlantic Meridional Overturning Circulation (AMOC) are assessed in a state-of-the-art global climate model (HadGEM3), with particular emphasis on Europe. This is the highest resolution coupled global climate model to be used to study the impacts of an AMOC slowdown so far. Many results found are consistent with previous studies and can be considered robust impacts from a large reduction or collapse of the AMOC. These include: widespread cooling throughout the North Atlantic and northern hemisphere in general; less precipitation in the northern hemisphere midlatitudes; large changes in precipitation in the tropics and a strengthening of the North Atlantic storm track. The focus on Europe, aided by the increase in resolution, has revealed previously undiscussed impacts, particularly those associated with changing atmospheric circulation patterns. Summer precipitation decreases (increases) in northern (southern) Europe and is associated with a negative summer North Atlantic Oscillation signal. Winter precipitation is also affected by the changing atmospheric circulation, with localised increases in precipitation associated with more winter storms and a strengthened winter storm track. Stronger westerly winds in winter increase the warming maritime effect while weaker westerlies in summer decrease the cooling maritime effect. In the absence of these circulation changes the cooling over Europe's landmass would be even larger in both seasons. The general cooling and atmospheric circulation changes result in weaker peak river flows and vegetation productivity, which may raise issues of water availability and crop production.

Stationary eddies in the Mars general circulation as simulated by the NASA-Ames GCM

NASA Technical Reports Server (NTRS)

Barnes, J. R.; Pollack, J. B.; Haberle, Robert M.

1993-01-01

Quasistationary eddies are prominent in a large set of simulations of the Mars general circulation performed with the NASA-Ames GCM. Various spacecraft observations have at least hinted at the existence of such eddies in the Mars atmosphere. The GCM stationary eddies appear to be forced primarily by the large Mars topography, and (to a much lesser degree) by spatial variations in the surface albedo and thermal inertia. The stationary eddy circulations exhibit largest amplitudes at high altitudes (above 30-40 km) in the winter extratropical regions. In these regions they are of planetary scale, characterized largely by zonal wavenumbers 1 and 2. Southern Hemisphere winter appears to be dominated by a very strong wave 1 pattern, with both waves 1 and 2 being prominent in the Northern Hemisphere winter regime. This difference seems to be basically understandable in terms of differences in the topography in the two hemispheres. The stationary eddies in the northern winter extratropics are found to increase in amplitude with dust loading. This behavior appears to be at least partly associated with changes in the structure of the zonal-mean flow that favor a greater response to wave 1 topographic forcing. There are also strong stationary eddy circulations in the tropics and in the summer hemisphere. The eddies in the summer subtropics and extratropics arc substantially stronger in southern summer than in northern summer. The summer hemisphere stationary circulations are relatively shallow and are characterized by smaller zonal scales than those in the winter extratropics.

Simulating pathways of subsurface oil in the Faroe-Shetland Channel using an ocean general circulation model.

PubMed

Main, C E; Yool, A; Holliday, N P; Popova, E E; Jones, D O B; Ruhl, H A

2017-01-15

Little is known about the fate of subsurface hydrocarbon plumes from deep-sea oil well blowouts and their effects on processes and communities. As deepwater drilling expands in the Faroe-Shetland Channel (FSC), oil well blowouts are a possibility, and the unusual ocean circulation of this region presents challenges to understanding possible subsurface oil pathways in the event of a spill. Here, an ocean general circulation model was used with a particle tracking algorithm to assess temporal variability of the oil-plume distribution from a deep-sea oil well blowout in the FSC. The drift of particles was first tracked for one year following release. Then, ambient model temperatures were used to simulate temperature-mediated biodegradation, truncating the trajectories of particles accordingly. Release depth of the modeled subsurface plumes affected both their direction of transport and distance travelled from their release location, and there was considerable interannual variability in transport. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Combination of Kinematics with Flow Visualization to Compute Total Circulation

NASA Technical Reports Server (NTRS)

Brasseur, J. G; Chang, I-Dee

1981-01-01

A method is described in which kinematics is exploited to compute the total circulation of a vortex from relatively simple flow visualization experiments. There are several advantages in the technique, including the newly acquired ability to calculate the changes in strength of a single vortex as it evolves. The main concepts and methodology are discussed in a general way for application to vortices which carry along with them definable regions of essentially irrotational fluid; however, the approach might be generalized to other flows which contain regions of concentrated vorticity. As an illustrative example, an application to the study of the transient changes in total circulation of individual vortex rings as they travel up a tube is described, taking into account the effect of the tube boundary. The accuracy of the method, assessed in part by a direct comparison with a laser Doppler measurement is felt to be well within experimental precision for vortex rings over a wide range of Reynolds numbers.

Stable isotopes of fossil teeth corroborate key general circulation model predictions for the Last Glacial Maximum in North America

NASA Astrophysics Data System (ADS)

Kohn, Matthew J.; McKay, Moriah

2010-11-01

Oxygen isotope data provide a key test of general circulation models (GCMs) for the Last Glacial Maximum (LGM) in North America, which have otherwise proved difficult to validate. High δ18O pedogenic carbonates in central Wyoming have been interpreted to indicate increased summer precipitation sourced from the Gulf of Mexico. Here we show that tooth enamel δ18O of large mammals, which is strongly correlated with local water and precipitation δ18O, is lower during the LGM in Wyoming, not higher. Similar data from Texas, California, Florida and Arizona indicate higher δ18O values than in the Holocene, which is also predicted by GCMs. Tooth enamel data closely validate some recent models of atmospheric circulation and precipitation δ18O, including an increase in the proportion of winter precipitation for central North America, and summer precipitation in the southern US, but suggest aridity can bias pedogenic carbonate δ18O values significantly.

A Pacific Ocean general circulation model for satellite data assimilation

NASA Technical Reports Server (NTRS)

Chao, Y.; Halpern, D.; Mechoso, C. R.

1991-01-01

A tropical Pacific Ocean General Circulation Model (OGCM) to be used in satellite data assimilation studies is described. The transfer of the OGCM from a CYBER-205 at NOAA's Geophysical Fluid Dynamics Laboratory to a CRAY-2 at NASA's Ames Research Center is documented. Two 3-year model integrations from identical initial conditions but performed on those two computers are compared. The model simulations are very similar to each other, as expected, but the simulations performed with the higher-precision CRAY-2 is smoother than that with the lower-precision CYBER-205. The CYBER-205 and CRAY-2 use 32 and 64-bit mantissa arithmetic, respectively. The major features of the oceanic circulation in the tropical Pacific, namely the North Equatorial Current, the North Equatorial Countercurrent, the South Equatorial Current, and the Equatorial Undercurrent, are realistically produced and their seasonal cycles are described. The OGCM provides a powerful tool for study of tropical oceans and for the assimilation of satellite altimetry data.

On-chip microwave circulators using quantum Hall plasmonics

NASA Astrophysics Data System (ADS)

Mahoney, Alice; Colless, James; Pauka, Sebastian; Hornibrook, John; Doherty, Andrew; Reilly, David; Peeters, Lucas; Fox, Eli; Goldhaber-Gordon, David; Kou, Xuefeng; Pan, Lei; Wang, Kang; Watson, John; Gardner, Geoffrey; Manfra, Michael

Circulators are directional circuit elements integral to technologies including radar systems, microwave communication transceivers and the readout of quantum information devices. Their non-reciprocity commonly arises from the interference of microwaves over the centimetre-scale of the signal wavelength in the presence of bulky magnetic media that breaks time-reversal symmetry. We present a completely passive on-chip microwave circulator with size 1/1000th the wavelength by exploiting the chiral, `slow-light' response of a GaAs/AlGaAs 2-dimensional electron gas in the quantum Hall regime. Further, by implementing this circulator design on a thin film of a magnetic topological insulator (Cr0.12(Bi0.26Sb0.62)2Te3), we show that similar non-reciprocity can be achieved at zero magnetic field. This additional mode of operation serves as a non-invasive probe of edge states in the quantum anomalous Hall effect, while also extending the possibility for integration with superconducting devices.

Complex Recanalization of Chronic Total Occluison Supported by Minimal Extracorporeal Circulation in a Patient with an Aortic Valve Bioprothesis in Extraanatomic Position

PubMed Central

Jansen, Ruben; Bathgate, Brigitte; Bufe, Alexander

2018-01-01

Percutaneous coronary intervention (PCI) of chronic total occlusion (CTO) still remains a major challenge in interventional cardiology. This case describes a complex PCI of the left main coronary artery and of a CTO of the right coronary artery using a minimal extracorporeal circulation system (MECC) in a patient with an aortic valve bioprothesis in extraanatomic position. It illustrates that complex recanalization strategies can be solved combining it with mechanical circulatory support technologies. PMID:29850264

Production of a small-circulation medical journal using desktop publishing methods.

PubMed

Peters, B A

1994-07-01

Since its inception in January 1988, the Baylor University Medical Center Proceedings, a quarterly medical journal, has been published by the few staff of the Scientific Publications Office (Baylor Research Institute, Dallas, Texas, USA) using microcomputers and page-makeup software in conjunction with a commercial printing company. This article outlines the establishment of the journal; the steps used in the publication process; the software and hardware used; and the changes in design, content, and circulation that have taken place as the journal and the technology used to create it have evolved.

Role of a cumulus parameterization scheme in simulating atmospheric circulation and rainfall in the nine-layer Goddard Laboratory for Atmospheres General Circulation Model

NASA Technical Reports Server (NTRS)

Sud, Y. C.; Chao, Winston C.; Walker, G. K.

1992-01-01

The influence of a cumulus convection scheme on the simulated atmospheric circulation and hydrologic cycle is investigated by means of a coarse version of the GCM. Two sets of integrations, each containing an ensemble of three summer simulations, were produced. The ensemble sets of control and experiment simulations are compared and differentially analyzed to determine the influence of a cumulus convection scheme on the simulated circulation and hydrologic cycle. The results show that cumulus parameterization has a very significant influence on the simulation circulation and precipitation. The upper-level condensation heating over the ITCZ is much smaller for the experiment simulations as compared to the control simulations; correspondingly, the Hadley and Walker cells for the control simulations are also weaker and are accompanied by a weaker Ferrel cell in the Southern Hemisphere. Overall, the difference fields show that experiment simulations (without cumulus convection) produce a cooler and less energetic atmosphere.

Slow and Steady: Ocean Circulation. The Influence of Sea Surface Height on Ocean Currents

NASA Technical Reports Server (NTRS)

Haekkinen, Sirpa

2000-01-01

The study of ocean circulation is vital to understanding how our climate works. The movement of the ocean is closely linked to the progression of atmospheric motion. Winds close to sea level add momentum to ocean surface currents. At the same time, heat that is stored and transported by the ocean warms the atmosphere above and alters air pressure distribution. Therefore, any attempt to model climate variation accurately must include reliable calculations of ocean circulation. Unlike movement of the atmosphere, movement of the ocean's waters takes place mostly near the surface. The major patterns of surface circulation form gigantic circular cells known as gyres. They are categorized according to their general location-equatorial, subtropical, subpolar, and polar-and may run across an entire ocean. The smaller-scale cell of ocean circulation is known' as an eddy. Eddies are much more common than gyres and much more difficult to track in computer simulations of ocean currents.

Detoxification of blood using injectable magnetic nanospheres: A conceptual technology description

NASA Astrophysics Data System (ADS)

Kaminski, Michael D.; Rosengart, Axel J.

2005-05-01

We describe injectable magnetic nanospheres as a vehicle for selective detoxification of blood borne toxins. Surface receptors on the freely circulating nanospheres bind to toxins. A hand-held extracorporeal magnetic filter separates the toxin-loaded nanospheres from the clean blood, which is returned to the patient. Details of the technology concept are given and include a state-of-knowledge and research needs.

JPRS Report, Science & Technology USSR: Chemistry

DTIC Science & Technology

1991-06-20

extremely water -intensive technological process that results in the pollution of natural waters by finely dispersed silt-and-clay suspensions that...against pollution . This review examines ways and means of reagent conditioning of circulating and waste waters during the development of placer deposits...in Water by Using Porous Sulfo Cation Exchange Resin [A. V Mamchenko, M.S. Novozhenyuk; KHIMIYA I TEKHNOLOGIYA VODY, Vol 13 No 1, Jan 91] ... 5

Deep circulations under simple classes of stratification

NASA Technical Reports Server (NTRS)

Salby, Murry L.

1989-01-01

Deep circulations where the motion field is vertically aligned over one or more scale heights are studied under barotropic and equivalent barotropic stratifications. The study uses two-dimensional equations reduced from the three-dimensional primitive equations in spherical geometry. A mapping is established between the full primitive equations and general shallow water behavior and the correspondence between variables describing deep atmospheric motion and those of shallow water behavior is established.

On the glacial and inter-glacial thermohaline circulation and the associated transports of heat and freshwater

NASA Astrophysics Data System (ADS)

Ballarotta, M.; Falahat, S.; Brodeau, L.; Döös, K.

2014-03-01

The change of the thermohaline circulation (THC) between the Last Glacial Maximum (LGM, ≈ 21 kyr ago) and the present day climate are explored using an Ocean General Circulation Model and stream functions projected in various coordinates. Compared to the present day period, the LGM circulation is reorganised in the Atlantic Ocean, in the Southern Ocean and particularly in the abyssal ocean, mainly due to the different haline stratification. Due to stronger wind stress, the LGM tropical circulation is more vigorous than under modern conditions. Consequently, the maximum tropical transport of heat is slightly larger during the LGM. In the North Atlantic basin, the large sea-ice extent during the LGM constrains the Gulf Stream to propagate in a more zonal direction, reducing the transport of heat towards high latitudes and reorganising the freshwater transport. The LGM circulation is represented as a large intrusion of saline Antarctic Bottom Water into the Northern Hemisphere basins. As a result, the North Atlantic Deep Water is shallower in the LGM simulation. The stream functions in latitude-salinity coordinates and thermohaline coordinates point out the different haline regimes between the glacial and interglacial period, as well as a LGM Conveyor Belt circulation largely driven by enhanced salinity contrast between the Atlantic and the Pacific basin. The thermohaline structure in the LGM simulation is the result of an abyssal circulation that lifts and deviates the Conveyor Belt cell from the area of maximum volumetric distribution, resulting in a ventilated upper layer above a deep stagnant layer, and an Atlantic circulation more isolated from the Pacific. An estimation of the turnover times reveal a deep circulation almost sluggish during the LGM, and a Conveyor Belt cell more vigorous due to the combination of stronger wind stress and shortened circulation route.

Global circulation as the main source of cloud activity on Titan

USGS Publications Warehouse

Rodriguez, S.; Le, Mouelic S.; Rannou, P.; Tobie, G.; Baines, K.H.; Barnes, J.W.; Griffith, C.A.; Hirtzig, M.; Pitman, K.M.; Sotin, Christophe; Brown, R.H.; Buratti, B.J.; Clark, R.N.; Nicholson, P.D.

2009-01-01

Clouds on Titan result from the condensation of methane and ethane and, as on other planets, are primarily structured by circulation of the atmosphere. At present, cloud activity mainly occurs in the southern (summer) hemisphere, arising near the pole and at mid-latitudes from cumulus updrafts triggered by surface heating and/or local methane sources, and at the north (winter) pole, resulting from the subsidence and condensation of ethane-rich air into the colder troposphere. General circulation models predict that this distribution should change with the seasons on a 15-year timescale, and that clouds should develop under certain circumstances at temperate latitudes (40??) in the winter hemisphere. The models, however, have hitherto been poorly constrained and their long-term predictions have not yet been observationally verified. Here we report that the global spatial cloud coverage on Titan is in general agreement with the models, confirming that cloud activity is mainly controlled by the global circulation. The non-detection of clouds at latitude 40??N and the persistence of the southern clouds while the southern summer is ending are, however, both contrary to predictions. This suggests that Titans equator-to-pole thermal contrast is overestimated in the models and that its atmosphere responds to the seasonal forcing with a greater inertia than expected. ?? 2009 Macmillan Publishers Limited. All rights reserved.

Middle Atmospheric Transport Properties of Assimilated Datasets

NASA Technical Reports Server (NTRS)

Pawson, Steven; Rood, Richard

1999-01-01

One of the most compelling reasons for performing data assimilation in the middle atmosphere is to obtain global, balanced datasets for studies of trace gas transport and chemistry. This is a major motivation behind the Goddard Earth observation System-Data Assimilation System (GEOS-DAS). Previous studies have shown that while this and other data assimilation systems can generally obtain good estimates of the extratropical rotational velocity field, the divergent part of the dynamical field is deficient; this impacts the "residual circulation" and leads to spurious trace gas transport on seasonal and interannual timescales. These problems are impacted by the quality and the method of use of the observational data and by deficiencies in the atmospheric general circulation model. Whichever the cause at any place and time, the "solution" is to introduce non-physical forcing terms into the system (the so-called incremental analysis updates); these can directly (thermal) or indirectly (mechanical) affect the residual circulation. This paper will illustrate how the divergent circulation is affected by deficiencies in both observations and models. Theoretical considerations will be illustrated with examples from the GEOS-DAS and from simplified numerical experiments. These are designed to isolate known problems, such as the inability of models to sustain a quasi-biennial oscillation and sparse observational constraints on tropical dynamics, or radiative inconsistencies in the presence of volcanic aerosols.

Middle Atmosphere Transport Properties of Assimilated Datasets

NASA Technical Reports Server (NTRS)

Pawson, Steven; Rood, Richard

1999-01-01

One of the most compelling reasons for performing data assimilation in the middle atmosphere is to obtain global, balanced datasets for studies of trace gas transport and chemistry. This is a major motivation behind the Goddard Earth observation System-Data Assimilation System (GEOS-DAS). Previous studies have shown that while this and other data assimilation systems can generally obtain good estimates of the extratropical rotational velocity field, the divergent part of the dynamical field is deficient; this impacts the "residual circulation" and leads to spurious trace gas transport on seasonal and interannual timescales. These problems are impacted by the quality and the method of use of the observational data and by deficiencies in the atmospheric general circulation model. Whichever the cause at any place and time, the "solution" is to introduce non-physical forcing terms into the system (the so-called incremental analysis updates); these can directly (thermal) or indirectly (mechanical) affect the residual circulation. This paper will illustrate how the divergent circulation is affected by deficiencies in both observations and models. Theoretical considerations will be illustrated with examples from the GEOS-DAS and from simplified numerical experiments. These are designed to isolate known problems, such as the inability of models to sustain a quasi-biennial oscillation and sparse observational constraints on tropical dynamics, or radiative inconsistencies in the presence of volcanic aerosols.

Immunity against influenza A(H1N1) infections is determined by age at the time of initial strain circulation.

PubMed

Delabre, R M; Salez, N; Lapidus, N; Lemaitre, M; Leruez-Ville, M; de Lamballerie, X; Carrat, F

2017-01-01

We explored age-dependent patterns in haemagglutination inhibition (HI) titre to seasonal [1956 A(H1N1), 1977 A(H1N1), 2007 A(H1N1)] and pandemic [A(H1N1)pdm09] influenza strains using serological data collected from an adult French influenza cohort. Subjects were recruited by their general practitioners from 2008 to 2009 and followed until 2010. We explored age-related differences between strain-specific HI titres using 1053 serological samples collected over the study period from 398 unvaccinated subjects. HI titres against the tested seasonal and pandemic strains were determined using the HI technique. Geometric mean titres (GMTs) were estimated using regression models for interval-censored data. Generalized additive mixed models were fit to log-transformed HI estimates to study the relationship between HI titre and age (age at inclusion and/or age at initial strain circulation). GMT against one strain was consistently highest in the birth cohort exposed to that strain during childhood, with peak titres observed in subjects aged 7-8 years at the time of initial strain circulation. Our results complete previous findings on influenza A(H3N2) strains and identify a strain-dependent relationship between HI titre and age at initial strain circulation.

Seasonal overturning circulation in the Red Sea: 2. Winter circulation

NASA Astrophysics Data System (ADS)

Yao, Fengchao; Hoteit, Ibrahim; Pratt, Larry J.; Bower, Amy S.; Köhl, Armin; Gopalakrishnan, Ganesh; Rivas, David

2014-04-01

The shallow winter overturning circulation in the Red Sea is studied using a 50 year high-resolution MITgcm (MIT general circulation model) simulation with realistic atmospheric forcing. The overturning circulation for a typical year, represented by 1980, and the climatological mean are analyzed using model output to delineate the three-dimensional structure and to investigate the underlying dynamical mechanisms. The horizontal model circulation in the winter of 1980 is dominated by energetic eddies. The climatological model mean results suggest that the surface inflow intensifies in a western boundary current in the southern Red Sea that switches to an eastern boundary current north of 24°N. The overturning is accomplished through a cyclonic recirculation and a cross-basin overturning circulation in the northern Red Sea, with major sinking occurring along a narrow band of width about 20 km along the eastern boundary and weaker upwelling along the western boundary. The northward pressure gradient force, strong vertical mixing, and horizontal mixing near the boundary are the essential dynamical components in the model's winter overturning circulation. The simulated water exchange is not hydraulically controlled in the Strait of Bab el Mandeb; instead, the exchange is limited by bottom and lateral boundary friction and, to a lesser extent, by interfacial friction due to the vertical viscosity at the interface between the inflow and the outflow.

Estimating Neutral Atmosphere Drivers using a Physical Model

DTIC Science & Technology

2009-03-30

Araujo-Pradere, M. Fedrizzi, 2007, Memory effects in the ionosphere storm response. EGU General Assembly , Vienna, Austria Codrescu, M., T.J. Fuller...Strickland, D, 2007: Application of thermospheric general circulation models for space weather operations. J. Adv. Space Res., edited by Schmidtke

Performance of computer vision in vivo flow cytometry with low fluorescence contrast

NASA Astrophysics Data System (ADS)

Markovic, Stacey; Li, Siyuan; Niedre, Mark

2015-03-01

Detection and enumeration of circulating cells in the bloodstream of small animals are important in many areas of preclinical biomedical research, including cancer metastasis, immunology, and reproductive medicine. Optical in vivo flow cytometry (IVFC) represents a class of technologies that allow noninvasive and continuous enumeration of circulating cells without drawing blood samples. We recently developed a technique termed computer vision in vivo flow cytometry (CV-IVFC) that uses a high-sensitivity fluorescence camera and an automated computer vision algorithm to interrogate relatively large circulating blood volumes in the ear of a mouse. We detected circulating cells at concentrations as low as 20 cells/mL. In the present work, we characterized the performance of CV-IVFC with low-contrast imaging conditions with (1) weak cell fluorescent labeling using cell-simulating fluorescent microspheres with varying brightness and (2) high background tissue autofluorescence by varying autofluorescence properties of optical phantoms. Our analysis indicates that CV-IVFC can robustly track and enumerate circulating cells with at least 50% sensitivity even in conditions with two orders of magnitude degraded contrast than our previous in vivo work. These results support the significant potential utility of CV-IVFC in a wide range of in vivo biological models.

Numerical simulation of terrain-induced mesoscale circulation in the Chiang Mai area, Thailand

NASA Astrophysics Data System (ADS)

Sathitkunarat, Surachai; Wongwises, Prungchan; Pan-Aram, Rudklao; Zhang, Meigen

2008-11-01

The regional atmospheric modeling system (RAMS) was applied to Chiang Mai province, a mountainous area in Thailand, to study terrain-induced mesoscale circulations. Eight cases in wet and dry seasons under different weather conditions were analyzed to show thermal and dynamic impacts on local circulations. This is the first study of RAMS in Thailand especially investigating the effect of mountainous area on the simulated meteorological data. Analysis of model results indicates that the model can reproduce major features of local circulation and diurnal variations in temperatures. For evaluating the model performance, model results were compared with observed wind speed, wind direction, and temperature monitored at a meteorological tower. Comparison shows that the modeled values are generally in good agreement with observations and that the model captured many of the observed features.

Application of single-cell technology in cancer research.

PubMed

Liang, Shao-Bo; Fu, Li-Wu

2017-07-01

In this review, we have outlined the application of single-cell technology in cancer research. Single-cell technology has made encouraging progress in recent years and now provides the means to detect rare cancer cells such as circulating tumor cells and cancer stem cells. We reveal how this technology has advanced the analysis of intratumor heterogeneity and tumor epigenetics, and guided individualized treatment strategies. The future prospects now are to bring single-cell technology into the clinical arena. We believe that the clinical application of single-cell technology will be beneficial in cancer diagnostics and treatment, and ultimately improve survival in cancer patients. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

The global geochemistry of bomb-produced tritium - General circulation model compared to available observations and traditional interpretations

NASA Technical Reports Server (NTRS)

Koster, Randal D.; Broecker, Wallace S.; Jouzel, Jean; Suozzo, Robert J.; Russell, Gary L.; Rind, David

1989-01-01

Observational evidence suggests that of the tritium produced during nuclear bomb tests that has already reached the ocean, more than twice as much arrived through vapor impact as through precipitation. In the present study, the Goddard Institute for Space Studies 8 x 10 deg atmospheric general circulation model is used to simulate tritium transport from the upper atmosphere to the ocean. The simulation indicates that tritium delivery to the ocean via vapor impact is about equal to that via precipitation. The model result is relatively insensitive to several imposed changes in tritium source location, in model parameterizations, and in model resolution. Possible reasons for the discrepancy are explored.

Computer studies of baroclinic flow. [Atmospheric General Circulation Experiment

NASA Technical Reports Server (NTRS)

Gall, R.

1985-01-01

Programs necessary for computing the transition curve on the regime diagram for the atmospheric general circulation experiment (AGOE) were completed and used to determine the regime diagram for the rotating annulus and some axisymmetric flows for one possible AGOE configuration. The effect of geometrical constraints on the size of eddies developing from a basic state is being examined. In AGOE, the geometric constraint should be the width of the shear zone or the baroclinic zone. Linear and nonlinear models are to be used to examine both barotropic and baroclinic flows. The results should help explain the scale selection mechanism of baroclinic eddies in the atmosphere experimental models such as AGOE, and the multiple vortex phenomenon in tornadoes.

Interannual Variability of the Patagonian Shelf Circulation and Cross-Shelf Exchange

NASA Astrophysics Data System (ADS)

Combes, V.; Matano, R. P.

2016-02-01

Observational studies have already established the general mean circulation and hydrographic characteristics of the Patagonian shelf waters using data from in situ observation, altimetry and more recently from the Aquarius satellite sea surface salinity, but the paucity of those data in time or below the surface leave us with an incomplete picture of the shelf circulation and of its variability. This study discusses the variability of the Patagonian central shelf circulation and off-shelf transport using a high-resolution model experiment for the period 1979-2012. The model solution shows high skill in reproducing the best-known aspects of the shelf and deep-ocean circulations. This study links the variability of the central shelf circulation and off-shelf transport to the wind variability, southern shelf transport variability and large-scale current variability. We find that while the inner and central shelf circulation are principally wind driven, the contribution of the Brazil/Malvinas Confluence (BMC) variability becomes important in the outer shelf and along the shelf break. The model also indicates that whereas the location of the off-shelf transport is controlled by the BMC, its variability is modulated by the southern shelf transport. The variability of the subtropical shelf front, where the fresh southern shelf waters encounters the saline northern shelf waters, is also presented in this study.

Honors

NASA Astrophysics Data System (ADS)

Anonymous

2012-10-01

Many AGU members are among the American Meteorological Society's (AMS) 2013 honorary members, awardees, lecturers, and fellows. Among the AMS honorary members is Susan Solomon, the Ellen Swallow Richards Professor of Atmospheric Chemistry and Climate Science at the Massachusetts Institute of Technology (MIT). Dennis Hartmann, of the University of Washington, Seattle, is the recipient of AMS's Carl-Gustaf Rossby Research Medal "for significant contributions to the synthesis of knowledge of radiative and dynamical processes leading to a deeper understanding of the climate system." R. Alan Plumb, professor of meteorology at MIT, receives the Jule G. Charney Award "for fundamental contributions to the understanding of geophysical fluid dynamics, stratospheric dynamics, chemical transport, and the general circulation of the atmosphere and oceans." The Verner E. Suomi Award has been given to Richard Johnson, professor of atmospheric science at Colorado State University, Fort Collins, "for exquisite design of rawinsonde networks in field campaigns and insightful analysis of interactions between convective clouds and the largescale atmospheric circulation." W. Kendall Melville, professor of oceanography at the Scripps Institution of Oceanography, University of California, San Diego, has been awarded the Sverdrup Gold Medal Award "for pioneering contributions in advancing knowledge on the role of surface wave breaking and related processes in air-sea interaction." AMS announced that Laurence Armi, also a professor of oceanography at Scripps, is recipient of the Henry Stommel Research Award "for his deeply insightful studies of stratified flow, his pioneering work on boundary mixing and other turbulent mechanisms."

The Future Revisited.

ERIC Educational Resources Information Center

Mason, Marilyn Gell

1996-01-01

Reviews earlier predictions about technological change in libraries, finds that providing equal access to information remains the library's mission, and forecasts the future. Topics include ownership versus access, electronic resources, information infrastructure, users, levels of service fees, circulation, librarians as "information…

IN SITU BIOREMEDIATION STRATEGIES FOR ORGANIC WOOD PRESERVATIVES

EPA Science Inventory

Laboratory biotreatability studies evaluated the use of bioventing and biosparging plus groundwater circulation (UVB technology) for their potential abililty to treat soil and groundwater containing creosote and pentachlorophenol. Soils from two former wood-treatment facilities w...

Microfluidic strategies for understanding the mechanics of cells and cell-mimetic systems

PubMed Central

Dahl, Joanna B.; Lin, Jung-Ming G.; Muller, Susan J.; Kumar, Sanjay

2016-01-01

Microfluidic systems are attracting increasing interest for the high-throughput measurement of cellular biophysical properties and for the creation of engineered cellular microenvironments. Here we review recent applications of microfluidic technologies to the mechanics of living cells and synthetic cell-mimetic systems. We begin by discussing the use of microfluidic devices to dissect the mechanics of cellular mimics such as capsules and vesicles. We then explore applications to circulating cells, including erythrocytes and other normal blood cells, and rare populations with potential disease diagnostic value, such as circulating tumor cells. We conclude by discussing how microfluidic devices have been used to investigate the mechanics, chemotaxis, and invasive migration of adherent cells. In these ways, microfluidic technologies represent an increasingly important toolbox for investigating cellular mechanics and motility at high throughput and in a format that lends itself to clinical translation. PMID:26134738

Nanostructured Substrates for Capturing Circulating Tumor Cells in Whole Blood

NASA Astrophysics Data System (ADS)

Tseng, Hsian-Rong

2009-03-01

Over the past decade, circulating tumor cells (CTCs) has become an emerging ``biomarker'' for detecting early-stage cancer metastasis, predicting patient prognosis, as well as monitoring disease progression and therapeutic outcomes. However, isolation of CTCs has been technically challenging due to the extremely low abundance (a few to hundreds per ml) of CTCs among a high number of hematologic cells (109 per mL) in the blood. Our joint research team at UCLA has developed a new cell capture technology for quantification of CTCs in whole blood samples. Similar to most of the existing approaches, epithelial cell adhesion molecule antibody (anti-EpCAM) was grafted onto the surfaces to distinguish CTCs from the surrounding hematologic cells. The uniqueness of our technology is the use of nanostructured surfaces, which facilitates local topographical interactions between CTCs and substrates at the very first cell/substrate contacting time point. We demonstrated the ability of these nanostructured substrates to capture CTCs in whole blood samples with significantly improved efficiency and selectivity. The successful demonstration of this cell capture technology using brain, breast and prostate cancer cell lines encouraged us to test this approach in clinical setting. We have been able to bond our first validation study with a commercialized technology based on the use of immunomagnetic nanoparticles. A group of clinically well-characterized prostate cancer patients at UCLA hospital have been recruited and tested in parallel by these two technologies.

7 CFR 58.422 - Brine tank.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) GRADING AND INSPECTION, GENERAL SPECIFICATIONS FOR APPROVED PLANTS AND STANDARDS FOR GRADES OF DAIRY PRODUCTS 1 General... clean, well circulated, and of the proper strength and temperature for the variety of cheese being made. ...

Climate Change Impacts on Agriculture and Food Security in 2050 under a Range of Plausible Socioeconomic and Emissions Scenarios

NASA Astrophysics Data System (ADS)

Wiebe, K.; Lotze-Campen, H.; Bodirsky, B.; Kavallari, A.; Mason-d'Croz, D.; van der Mensbrugghe, D.; Robinson, S.; Sands, R.; Tabeau, A.; Willenbockel, D.; Islam, S.; van Meijl, H.; Mueller, C.; Robertson, R.

2014-12-01

Previous studies have combined climate, crop and economic models to examine the impact of climate change on agricultural production and food security, but results have varied widely due to differences in models, scenarios and data. Recent work has examined (and narrowed) these differences through systematic model intercomparison using a high-emissions pathway to highlight the differences. New work extends that analysis to cover a range of plausible socioeconomic scenarios and emission pathways. Results from three general circulation models are combined with one crop model and five global economic models to examine the global and regional impacts of climate change on yields, area, production, prices and trade for coarse grains, rice, wheat, oilseeds and sugar to 2050. Results show that yield impacts vary with changes in population, income and technology as well as emissions, but are reduced in all cases by endogenous changes in prices and other variables.

Universal influenza vaccines, a dream to be realized soon.

PubMed

Zhang, Han; Wang, Li; Compans, Richard W; Wang, Bao-Zhong

2014-04-29

Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine.

The principles of radio engineering and antennas. II Antennas (2nd revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Belotserkovskii, G. B.

This book represents the second part of a textbook for technical schools. The characteristics and parameters of antennas are considered along with transmission lines, the theory of single dipoles and radiator systems, and the technological realization of elements and units of the antenna-feeder system, taking into account filters and multiport networks for microwave communications applications, and ferrite circulators and isolators. The first edition of this textbook was published in 1969. For the current edition, the material in the first edition has been revised, and new material has been introduced. Much attention is given to microwave antennas, including, in particular, arrays with electrical scanning characteristics. Other topics discussed are related to the general principles of antennas, the matching of the impedance of transmission lines, the elements of transmission lines, aperture-type antennas for microwaves, and the functional characteristics of antennas for ultrashort waves.

Universal Influenza Vaccines, a Dream to Be Realized Soon

PubMed Central

Zhang, Han; Wang, Li; Compans, Richard W.; Wang, Bao-Zhong

2014-01-01

Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine. PMID:24784572

A cyclostrophic transformed Eulerian zonal mean model for the middle atmosphere of slowly rotating planets

NASA Astrophysics Data System (ADS)

Li, K. F.; Yao, K.; Taketa, C.; Zhang, X.; Liang, M. C.; Jiang, X.; Newman, C. E.; Tung, K. K.; Yung, Y. L.

2015-12-01

With the advance of modern computers, studies of planetary atmospheres have heavily relied on general circulation models (GCMs). Because these GCMs are usually very complicated, the simulations are sometimes difficult to understand. Here we develop a semi-analytic zonally averaged, cyclostrophic residual Eulerian model to illustrate how some of the large-scale structures of the middle atmospheric circulation can be explained qualitatively in terms of simple thermal (e.g. solar heating) and mechanical (the Eliassen-Palm flux divergence) forcings. This model is a generalization of that for fast rotating planets such as the Earth, where geostrophy dominates (Andrews and McIntyre 1987). The solution to this semi-analytic model consists of a set of modified Hough functions of the generalized Laplace's tidal equation with the cyclostrohpic terms. As examples, we apply this model to Titan and Venus. We show that the seasonal variations of the temperature and the circulation of these slowly-rotating planets can be well reproduced by adjusting only three parameters in the model: the Brunt-Väisälä bouyancy frequency, the Newtonian radiative cooling rate, and the Rayleigh friction damping rate. We will also discuss the application of this model to study the meridional transport of photochemically produced tracers that can be observed by space instruments.

Wave–turbulence interaction-induced vertical mixing and its effects in ocean and climate models

PubMed Central

Qiao, Fangli; Yuan, Yeli; Deng, Jia; Dai, Dejun; Song, Zhenya

2016-01-01

Heated from above, the oceans are stably stratified. Therefore, the performance of general ocean circulation models and climate studies through coupled atmosphere–ocean models depends critically on vertical mixing of energy and momentum in the water column. Many of the traditional general circulation models are based on total kinetic energy (TKE), in which the roles of waves are averaged out. Although theoretical calculations suggest that waves could greatly enhance coexisting turbulence, no field measurements on turbulence have ever validated this mechanism directly. To address this problem, a specially designed field experiment has been conducted. The experimental results indicate that the wave–turbulence interaction-induced enhancement of the background turbulence is indeed the predominant mechanism for turbulence generation and enhancement. Based on this understanding, we propose a new parametrization for vertical mixing as an additive part to the traditional TKE approach. This new result reconfirmed the past theoretical model that had been tested and validated in numerical model experiments and field observations. It firmly establishes the critical role of wave–turbulence interaction effects in both general ocean circulation models and atmosphere–ocean coupled models, which could greatly improve the understanding of the sea surface temperature and water column properties distributions, and hence model-based climate forecasting capability. PMID:26953182

Detection of greenhouse-gas-induced climatic change. Progress report, July 1, 1994--July 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, P.D.; Wigley, T.M.L.

1995-07-21

The objective of this research is to assembly and analyze instrumental climate data and to develop and apply climate models as a basis for detecting greenhouse-gas-induced climatic change, and validation of General Circulation Models. In addition to changes due to variations in anthropogenic forcing, including greenhouse gas and aerosol concentration changes, the global climate system exhibits a high degree of internally-generated and externally-forced natural variability. To detect the anthropogenic effect, its signal must be isolated from the ``noise`` of this natural climatic variability. A high quality, spatially extensive data base is required to define the noise and its spatial characteristics.more » To facilitate this, available land and marine data bases will be updated and expanded. The data will be analyzed to determine the potential effects on climate of greenhouse gas and aerosol concentration changes and other factors. Analyses will be guided by a variety of models, from simple energy balance climate models to coupled atmosphere ocean General Circulation Models. These analyses are oriented towards obtaining early evidence of anthropogenic climatic change that would lead either to confirmation, rejection or modification of model projections, and towards the statistical validation of General Circulation Model control runs and perturbation experiments.« less

A cyclostrophic transformed Eulerian zonal mean model for the middle atmosphere of slowly rotating planets

NASA Astrophysics Data System (ADS)

Li, King-Fai; Yao, Kaixuan; Taketa, Cameron; Zhang, Xi; Liang, Mao-Chang; Jiang, Xun; Newman, Claire; Tung, Ka-Kit; Yung, Yuk L.

2016-04-01

With the advance of modern computers, studies of planetary atmospheres have heavily relied on general circulation models (GCMs). Because these GCMs are usually very complicated, the simulations are sometimes difficult to understand. Here we develop a semi-analytic zonally averaged, cyclostrophic residual Eulerian model to illustrate how some of the large-scale structures of the middle atmospheric circulation can be explained qualitatively in terms of simple thermal (e.g. solar heating) and mechanical (the Eliassen-Palm flux divergence) forcings. This model is a generalization of that for fast rotating planets such as the Earth, where geostrophy dominates (Andrews and McIntyre 1987). The solution to this semi-analytic model consists of a set of modified Hough functions of the generalized Laplace's tidal equation with the cyclostrohpic terms. As an example, we apply this model to Titan. We show that the seasonal variations of the temperature and the circulation of these slowly-rotating planets can be well reproduced by adjusting only three parameters in the model: the Brunt-Väisälä bouyancy frequency, the Newtonian radiative cooling rate, and the Rayleigh friction damping rate. We will also discuss an application of this model to study the meridional transport of photochemically produced tracers that can be observed by space instruments.

The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution.

PubMed

Krauskopf, Julian; Caiment, Florian; van Veldhoven, Karin; Chadeau-Hyam, Marc; Sinharay, Rudy; Chung, Kian Fan; Cullinan, Paul; Collins, Peter; Barratt, Benjamin; Kelly, Frank J; Vermeulen, Roel; Vineis, Paolo; de Kok, Theo M; Kleinjans, Jos C

2018-04-01

Traffic-related air pollution is a complex mixture of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide (NO2). PM exposure contributes to the pathogenesis of many diseases including several types of cancer, as well as pulmonary, cardiovascular and neurodegenerative diseases. Also exposure to NO2 has been related to increased cardiovascular mortality. In search of an early diagnostic biomarker for improved air pollution-associated health risk assessment, recent human studies have shown that certain circulating miRNAs are altered upon exposure to traffic-related air pollutants. Here, we present for the first time a global analysis of the circulating miRNA genome in an experimental cross-over study of a human population exposed to traffic-related air pollution. By utilizing next-generation sequencing technology and detailed real-time exposure measurements we identified 54 circulating miRNAs to be dose- and pollutant species-dependently associated with PM10, PM2.5, black carbon, ultrafine particles and NO2 already after 2 h of exposure. Bioinformatics analysis suggests that these circulating miRNAs actually reflect the adverse consequences of traffic pollution-induced toxicity in target tissues including the lung, heart, kidney and brain. This study shows the strong potential of circulating miRNAs as novel biomarkers for environmental health risk assessment. Copyright © 2018 Elsevier Ltd. All rights reserved.

Mid-latitude afforestation shifts general circulation and tropical precipitation.

PubMed

Swann, Abigail L S; Fung, Inez Y; Chiang, John C H

2012-01-17

We show in climate model experiments that large-scale afforestation in northern mid-latitudes warms the Northern Hemisphere and alters global circulation patterns. An expansion of dark forests increases the absorption of solar energy and increases surface temperature, particularly in regions where the land surface is unable to compensate with latent heat flux due to water limitation. Atmospheric circulation redistributes the anomalous energy absorbed in the northern hemisphere, in particular toward the south, through altering the Hadley circulation, resulting in the northward displacement of the tropical rain bands. Precipitation decreases over parts of the Amazon basin affecting productivity and increases over the Sahel and Sahara regions in Africa. We find that the response of climate to afforestation in mid-latitudes is determined by the amount of soil moisture available to plants with the greatest warming found in water-limited regions. Mid-latitude afforestation is found to have a small impact on modeled global temperatures and on global CO(2), but regional heating from the increase in forest cover is capable of driving unintended changes in circulation and precipitation. The ability of vegetation to affect remote circulation has implications for strategies for climate mitigation.

Seasonal Water Transport in the Atmosphere of Mars: Applications of a Mars General Circulation Model Using Mars Global Surveyor Data

NASA Technical Reports Server (NTRS)

Hollingsworth, Jeffery L.; Bridger, Alison F. C.; Haberle, Robert M.

1999-01-01

This is a Final Report for a Joint Research Interchange (JRI) between NASA Ames Research Center and San Jose State University, Department of Meteorology. We present below a summary of progress made during the duration of this JRI. The focus of this JRI has been to investigate seasonal water vapor transport in the atmosphere of Mars and its effects on the planet's present climate. To this end, the primary task has been to adapt a new dynamical processor for the adiabatic tendencies of the atmospheric circulation into the NASA Ames Mars general circulation model (MGCM). Using identical boundary and initial conditions, several comparative tests between the new and old MGCMs have been performed and the nature of the simulated circulations have been diagnosed. With confidence that the updated version of the Ames MGCM produces quite similar mean and eddy circulation statistics, the new climate model is well poised as a tool to pursue fundamental questions related to the spatial and seasonal variations of atmospheric water vapor on Mars, and to explore exchanges of water with non-atmospheric reservoirs and transport within its atmosphere. In particular, the role of surface sources and sinks can be explored, the range of water-vapor saturation altitudes can be investigated, and plausible precipitation mechanisms can be studied, for a range of atmospheric dust loadings. Such future investigations can contribute to a comprehensive study of surface inventories, exchange mechanisms, and the relative importance of atmospheric transport Mars' water cycle. A listing of presentations made and manuscripts submitted during the course of this project is provided.

Seasonal Water Transport in the Atmosphere of Mars: Applications of a Mars General Circulation Model Using Mars Global Surveyor Data

NASA Technical Reports Server (NTRS)

Hollingsworth, Jeffery L.; Bridger, Alison F. C.; Haberle, Robert M.

1999-01-01

This is a Final Report for a Joint Research Interchange (JRI) between NASA Ames Research Center and San Jose State University, Department of Meteorology. We present below a summary of progress made during the duration of this JRI. The focus of this JRI has been to investigate seasonal water vapor transport in the atmosphere of Mars and its effects on the planet's present climate. To this end, the primary task has been to adapt a new dynamical processor for the adiabatic tendencies of the atmospheric circulation into the NASA Ames Mars general circulation model (MGCM). Using identical boundary and initial conditions, several comparative tests between the new and old MGCMs have been performed and the nature of the simulated circulations have been diagnosed. With confidence that the updated version of the Ames MGCM produces quite similar mean and eddy circulation statistics, the new climate model is well poised as a tool to pursue fundamental questions related to the spatial and seasonal variations of atmospheric water vapor on Mars, and to explore exchanges of water with non-atmospheric reservoirs and transport within its atmosphere. In particular, the role of surface sources and sinks can be explored, the range of water-vapor saturation altitudes can be investigated, and plausible precipitation mechanisms can be studied, for a range of atmospheric dust loadings, such future investigations can contribute to a comprehensive study of surface inventories, exchange mechanisms, and the relative importance of atmospheric transport Mars' water cycle. A listing of presentations made and manuscripts submitted during the course of this project is provided.

Multimillennium changes in dissolved oxygen under global warming: results from an AOGCM and offline ocean biogeochemical model

NASA Astrophysics Data System (ADS)

Yamamoto, A.; Abe-Ouchi, A.; Shigemitsu, M.; Oka, A.; Takahashi, K.; Ohgaito, R.; Yamanaka, Y.

2016-12-01

Long-term oceanic oxygen change due to global warming is still unclear; most future projections (such as CMIP5) are only performed until 2100. Indeed, few previous studies using conceptual models project oxygen change in the next thousands of years, showing persistent global oxygen reduction by about 30% in the next 2000 years, even after atmospheric carbon dioxide stops rising. Yet, these models cannot sufficiently represent the ocean circulation change: the key driver of oxygen change. Moreover, considering serious effect oxygen reduction has on marine life and biogeochemical cycling, long-term oxygen change should be projected for higher validity. Therefore, we used a coupled atmosphere-ocean general circulation model (AOGCM) and an offline ocean biogeochemical model, investigating realistic long-term changes in oceanic oxygen concentration and ocean circulation. We integrated these models for 2000 years under atmospheric CO2 doubling and quadrupling. After global oxygen reduction in the first 500 years, oxygen concentration in deep ocean globally recovers and overshoots, despite surface oxygen decrease and weaker Atlantic Meridional Overturning Circulation. Deep ocean convection in the Weddell Sea recovers and overshoots, after initial cessation. Thus, enhanced deep convection and associated Antarctic Bottom Water supply oxygen-rich surface waters to deep ocean, resulting global deep ocean oxygenation. We conclude that the change in ocean circulation in the Southern Ocean potentially drives millennial-scale oxygenation in the deep ocean; contrary to past reported long-term oxygen reduction and general expectation. In presentation, we will discuss the mechanism of response of deep ocean convection in the Weddell Sea and show the volume changes of hypoxic waters.

Science and Technology in Greek Newspapers, 1900-1910. Historiographical Reflections and the Role of Journalists for the Public Images of Science and Technology

ERIC Educational Resources Information Center

Mergoupi-Savaidou, Eirini; Papanelopoulou, Faidra; Tzokas, Spyros

2012-01-01

Based on our research on two Athenian daily newspapers for the first decade of the twentieth century, we present some historiographical reflections concerning the role of the daily press in the circulation of scientific knowledge, ideas and practices. From the wealth of material provided, we examine some of the ways in which scientific and…

Fourier Ptychographic Microscopy for Rapid, High-Resolution Imaging of Circulating Tumor Cells Enriched by Microfiltration.

PubMed

Williams, Anthony; Chung, Jaebum; Yang, Changhuei; Cote, Richard J

2017-01-01

Examining the hematogenous compartment for evidence of metastasis has increased significantly within the oncology research community in recent years, due to the development of technologies aimed at the enrichment of circulating tumor cells (CTCs), the subpopulation of primary tumor cells that gain access to the circulatory system and are responsible for colonization at distant sites. In contrast to other technologies, filtration-based CTC enrichment, which exploits differences in size between larger tumor cells and surrounding smaller, non-tumor blood cells, has the potential to improve CTC characterization through isolation of tumor cell populations with greater molecular heterogeneity. However, microscopic analysis of uneven filtration surfaces containing CTCs is laborious, time-consuming, and inconsistent, preventing widespread use of filtration-based enrichment technologies. Here, integrated with a microfiltration-based CTC and rare cell enrichment device we have previously described, we present a protocol for Fourier Ptychographic Microscopy (FPM), a method that, unlike many automated imaging platforms, produces high-speed, high-resolution images that can be digitally refocused, allowing users to observe objects of interest present on multiple focal planes within the same image frame. The development of a cost-effective and high-throughput CTC analysis system for filtration-based enrichment technologies could have profound clinical implications for improved CTC detection and analysis.

Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses.

PubMed

Rubenstein, David A; Hom, Sarah; Ghebrehiwet, Berhane; Yin, Wei

2015-10-01

Kupffer cells are liver resident macrophages that are responsible for screening and clearing blood of pathogens and foreign particles. It has recently been shown that Kupffer cells interact with platelets, through an adhesion based mechanism, to aid in pathogen clearance and then these platelets re-enter the general systemic circulation. Thus, a mechanism has been identified that relates liver inflammation to possible changes in the systemic circulation. However, the role that Kupffer cells play in cardiovascular disease initiation/progression has not been elucidated. Thus, our objective was to determine whether or not Kupffer cells are responsive to a classical cardiovascular risk factor and if these changes can be transmitted into the general systemic circulation. If Kupffer cells initiate inflammatory responses after exposure to classical cardiovascular risk factors, then this provides a potential alternative/synergistic pathway for cardiovascular disease initiation. We aimed to elucidate the prevalence of this potential pathway. We hypothesized that Kupffer cells would initiate a robust inflammatory response after exposure to tobacco cigarette or e-cigarette products and that the inflammatory response would have the potential to antagonize other salient cells for cardiovascular disease progression. To test this, Kupffer cells were incubated with tobacco smoke extracts, e-cigarette vapor extracts or pure nicotine. Complement deposition onto Kupffer cells, Kupffer cell complement receptor expression, oxidative stress production, cytokine release and viability and density were assessed after the exposure. We observed a robust inflammatory response, oxidative stress production and cytokine release after Kupffer cells were exposed to tobacco or e-cigarette extracts. We also observed a marginal decrease in cell viability coupled with a significant decrease in cell density. In general, this was not a function of the extract formulation (e.g. tobacco vs. e-cigarette products or the formulation of the cigarette product). These results indicate that Kupffer cells are responsive to classical cardiovascular risk factors and that an inflammatory response is initiated that may pass into the general systemic circulation. Copyright © 2015 Elsevier Ltd. All rights reserved.

Optimization of circulating cell-free DNA recovery for KRAS mutation and HPV detection in plasma.

PubMed

Mazurek, Agnieszka M; Fiszer-Kierzkowska, A; Rutkowski, T; Składowski, K; Pierzyna, M; Scieglińska, D; Woźniak, G; Głowacki, G; Kawczyński, R; Małusecka, E

2013-01-01

The precise analysis of tumour markers in blood such as circulating cell-free DNA (cfDNA) could have a significant impact in facilitating monitoring of patients after initial therapy. Although high levels of total cfDNA in plasma of cancer patients are consistently demonstrated, a low sensitivity of DNA alterations is reported. The major question regards the recovery of tumour-specific cfDNA such as KRAS mutated DNA and cancer-associated type 16 of human papillomavirus (HPV16). TaqMan technology was used for detection of KRAS mutation, HPV16 and to quantify cfDNA in blood plasma. Comparison of four different column-based commercial kits shows that the cfDNA purification carried out by the Genomic Mini AX Body Fluids kit and the QIAamp Circulating Nucleic Acid kit gave us the possibility to improve the sensitivity of detection of KRAS mutation and HPV16. The optimized method was used to follow the reduction in cancer-specific cfDNA after therapy. We found that large volume extractions with low volume of DNA eluate enabled trace amounts of tumour-specific cfDNA from cancer patients to be effectively identified. Data presented in this study facilitate detection of tumour-specific cfDNA and improve standards needed for the implementation of cfDNA technology into routine clinical practice.

Review of the role of NICE in promoting the adoption of innovative cardiac technologies.

PubMed

Groves, Peter H; Pomfrett, Chris; Marlow, Mirella

2018-05-17

The National Institute for Health and Care Excellence (NICE) Medical Technologies Evaluation Programme (MTEP) promotes the adoption of innovative diagnostic and therapeutic technologies into National Health Service (NHS) clinical practice through the publication of guidance and briefing documents. Since the inception of the programme in 2009, there have been 7 medical technologiesguidance, 3 diagnostics guidance and 23 medtechinnovation briefing documents published that are relevant to the heart and circulation. Medical technologies guidance is published by NICE for selected single technologies if they offer plausible additional benefits to patients and the healthcare system. Diagnostic guidance is published for diagnostic technologies if they have the potential to improve health outcomes, but if their introduction may be associated with an increase in overall cost to the NHS. Medtechinnovation briefings provide evidence-based advice to those considering the implementation of new medical devices or diagnostic technologies. This review provides reference to all of the guidance and briefing medical technology documents that NICE has published that are relevant to the heart and circulation and reflect on their diverse recommendations. The interaction of MTEP with other NICE programmes is integral to its effectiveness and the means by which consistency is ensured across the different NICE programmes is described. The importance of the input of clinical experts from the cardiovascular professional community and the engagement by NICE with cardiovascular professional societies is highlighted as being fundamental to ensuring the quality of guidance outputs as well as to promoting their implementation and adoption. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Circulating Tumor Cell Isolation and Analysis

PubMed Central

Zhang, J.; Chen, K.; Fan, Z.H.

2016-01-01

Isolation and analysis of cancer cells from body fluids have significant implications in diagnosis and therapeutic treatment of cancers. Circulating tumor cells (CTCs) are cancer cells circulating in the peripheral blood or spreading iatrogenically into blood vessels, which is an early step in the cascade of events leading to cancer metastasis. Therefore, CTCs can be used for diagnosing for therapeutic treatment, prognosing a given anticancer intervention, and estimating the risk of metastatic relapse. However, isolation of CTCs is a significant technological challenge due to their rarity and low recovery rate using traditional purification techniques. Recently microfluidic devices represent a promising platform for isolating cancer cells with high efficiency in processing complex cellular fluids, with simplicity, sensitivity, and throughput. This review summarizes recent methods of CTC isolation and analysis, as well as their applications in clinical studies. PMID:27346614

Circulating Tumor Cell Isolation and Analysis.

PubMed

Zhang, J; Chen, K; Fan, Z H

Isolation and analysis of cancer cells from body fluids have significant implications in diagnosis and therapeutic treatment of cancers. Circulating tumor cells (CTCs) are cancer cells circulating in the peripheral blood or spreading iatrogenically into blood vessels, which is an early step in the cascade of events leading to cancer metastasis. Therefore, CTCs can be used for diagnosing for therapeutic treatment, prognosing a given anticancer intervention, and estimating the risk of metastatic relapse. However, isolation of CTCs is a significant technological challenge due to their rarity and low recovery rate using traditional purification techniques. Recently microfluidic devices represent a promising platform for isolating cancer cells with high efficiency in processing complex cellular fluids, with simplicity, sensitivity, and throughput. This review summarizes recent methods of CTC isolation and analysis, as well as their applications in clinical studies. © 2016 Elsevier Inc. All rights reserved.

On-Chip Microwave Quantum Hall Circulator

NASA Astrophysics Data System (ADS)

Mahoney, A. C.; Colless, J. I.; Pauka, S. J.; Hornibrook, J. M.; Watson, J. D.; Gardner, G. C.; Manfra, M. J.; Doherty, A. C.; Reilly, D. J.

2017-01-01

Circulators are nonreciprocal circuit elements that are integral to technologies including radar systems, microwave communication transceivers, and the readout of quantum information devices. Their nonreciprocity arises from the interference of microwaves over the centimeter scale of the signal wavelength, in the presence of bulky magnetic media that breaks time-reversal symmetry. Here, we realize a completely passive on-chip microwave circulator with size 1 /1000 th the wavelength by exploiting the chiral, "slow-light" response of a two-dimensional electron gas in the quantum Hall regime. For an integrated GaAs device with 330 μ m diameter and about 1-GHz center frequency, a nonreciprocity of 25 dB is observed over a 50-MHz bandwidth. Furthermore, the nonreciprocity can be dynamically tuned by varying the voltage at the port, an aspect that may enable reconfigurable passive routing of microwave signals on chip.

SCIENCE AND TECHNOLOGY OF CLEAN PROCESSING [EDITORIAL

EPA Science Inventory

Cleaner production methods, pollution prevention, and industrial ecology are the focuses of several journals in circulation. Aspects of cleaner products and processes are also implicitly covered in many established scientific and engineering journals. This journal has two main o...

Anisotropic Mesoscale Eddy Transport in Ocean General Circulation Models

NASA Astrophysics Data System (ADS)

Reckinger, S. J.; Fox-Kemper, B.; Bachman, S.; Bryan, F.; Dennis, J.; Danabasoglu, G.

2014-12-01

Modern climate models are limited to coarse-resolution representations of large-scale ocean circulation that rely on parameterizations for mesoscale eddies. The effects of eddies are typically introduced by relating subgrid eddy fluxes to the resolved gradients of buoyancy or other tracers, where the proportionality is, in general, governed by an eddy transport tensor. The symmetric part of the tensor, which represents the diffusive effects of mesoscale eddies, is universally treated isotropically in general circulation models. Thus, only a single parameter, namely the eddy diffusivity, is used at each spatial and temporal location to impart the influence of mesoscale eddies on the resolved flow. However, the diffusive processes that the parameterization approximates, such as shear dispersion, potential vorticity barriers, oceanic turbulence, and instabilities, typically have strongly anisotropic characteristics. Generalizing the eddy diffusivity tensor for anisotropy extends the number of parameters to three: a major diffusivity, a minor diffusivity, and the principal axis of alignment. The Community Earth System Model (CESM) with the anisotropic eddy parameterization is used to test various choices for the newly introduced parameters, which are motivated by observations and the eddy transport tensor diagnosed from high resolution simulations. Simply setting the ratio of major to minor diffusivities to a value of five globally, while aligning the major axis along the flow direction, improves biogeochemical tracer ventilation and reduces global temperature and salinity biases. These effects can be improved even further by parameterizing the anisotropic transport mechanisms in the ocean.

Comparing the Degree of Land-Atmosphere Interaction in Four Atmospheric General Circulation Models

NASA Technical Reports Server (NTRS)

Koster, Randal D.; Dirmeyer, Paul A.; Hahmann, Andrea N.; Ijpelaar, Ruben; Tyahla, Lori; Cox, Peter; Suarez, Max J.; Houser, Paul R. (Technical Monitor)

2001-01-01

Land-atmosphere feedback, by which (for example) precipitation-induced moisture anomalies at the land surface affect the overlying atmosphere and thereby the subsequent generation of precipitation, has been examined and quantified with many atmospheric general circulation models (AGCMs). Generally missing from such studies, however, is an indication of the extent to which the simulated feedback strength is model dependent. Four modeling groups have recently performed a highly controlled numerical experiment that allows an objective inter-model comparison of land-atmosphere feedback strength. The experiment essentially consists of an ensemble of simulations in which each member simulation artificially maintains the same time series of surface prognostic variables. Differences in atmospheric behavior between the ensemble members then indicates the degree to which the state of the land surface controls atmospheric processes in that model. A comparison of the four sets of experimental results shows that feedback strength does indeed vary significantly between the AGCMs.

What causes Mars' annular polar vortices?

NASA Astrophysics Data System (ADS)

Toigo, A. D.; Waugh, D. W.; Guzewich, S. D.

2017-01-01

A distinctive feature of the Martian atmosphere is that the winter polar vortices exhibit annuli of high potential vorticity (PV) with a local minimum near the pole. These annuli are seen in observations, reanalyses, and free-running general circulation model simulations of Mars, but are not generally a feature of Earth's polar vortices, where there is a monotonic increase in magnitude of PV with latitude. The creation and maintenance of the annular polar vortices on Mars are not well understood. Here we use simulations with a Martian general circulation model to the show that annular vortices are related to another distinctive, and possibly unique in the solar system, feature of the Martian atmosphere: the condensation of the predominant atmospheric gas species (CO2) in polar winter regions. The latent heat associated with CO2 condensation leads to destruction of PV in the polar lower atmosphere, inducing the formation of an annular PV structure.

Spherical harmonic analysis of a synoptic climatology generated with a global general circulation model

NASA Technical Reports Server (NTRS)

Christidis, Z. D.; Spar, J.

1980-01-01

Spherical harmonic analysis was used to analyze the observed climatological (C) fields of temperature at 850 mb, geopotential height at 500 mb, and sea level pressure. The spherical harmonic method was also applied to the corresponding "model climatological" fields (M) generated by a general circulation model, the "GISS climate model." The climate model was initialized with observed data for the first of December 1976 at 00. GMT and allowed to generate five years of meteorological history. Monthly means of the above fields for the five years were computed and subjected to spherical harmonic analysis. It was found from the comparison of the spectral components of both sets, M and C, that the climate model generated reasonable 500 mb geopotential heights. The model temperature field at 850 mb exhibited a generally correct structure. However, the meridional temperature gradient was overestimated and overheating of the continents was observed in summer.

Using in-situ observations of atmospheric water vapor isotopes to benchmark and isotope-enabled General Circulation Models and improve ice core paleo-climate reconstruction

NASA Astrophysics Data System (ADS)

Steen-Larsen, Hans Christian; Sveinbjörnsdottir, Arny; Masson-Delmotte, Valerie; Werner, Martin; Risi, Camille; Yoshimura, Kei

2016-04-01

We have since 2010 carried out in-situ continuous water vapor isotope observations on top of the Greenland Ice Sheet (3 seasons at NEEM), in Svalbard (1 year), in Iceland (4 years), in Bermuda (4 years). The expansive dataset containing high accuracy and precision measurements of δ18O, δD, and the d-excess allow us to validate and benchmark the treatment of the atmospheric hydrological cycle's processes in General Circulation Models using simulations nudged to reanalysis products. Recent findings from both Antarctica and Greenland have documented strong interaction between the snow surface isotopes and the near surface atmospheric water vapor isotopes on diurnal to synoptic time scales. In fact, it has been shown that the snow surface isotopes take up the synoptic driven atmospheric water vapor isotopic signal in-between precipitation events, erasing the precipitation isotope signal in the surface snow. This highlights the importance of using General or Regional Climate Models, which accurately are able to simulate the atmospheric water vapor isotopic composition, to understand and interpret the ice core isotope signal. With this in mind we have used three isotope-enabled General Circulation Models (isoGSM, ECHAM5-wiso, and LMDZiso) nudged to reanalysis products. We have compared the simulations of daily mean isotope values directly with our in-situ observations. This has allowed us to characterize the variability of the isotopic composition in the models and compared it to our observations. We have specifically focused on the d-excess in order to characterize why both the mean and the variability is significantly lower than our observations. We argue that using water vapor isotopes to benchmark General Circulation Models offers an excellent tool for improving the treatment and parameterization of the atmospheric hydrological cycle. Recent studies have documented a very large inter-model dispersion in the treatment of the Arctic water cycle under a future global warming and greenhouse gas emission scenario. Our results call for action to create an international pan-Arctic monitoring water vapor isotope network in order to improve future projections of Arctic climate.

Fast Adjustments of the Asian Summer Monsoon to Anthropogenic Aerosols

NASA Astrophysics Data System (ADS)

Li, Xiaoqiong; Ting, Mingfang; Lee, Dong Eun

2018-01-01

Anthropogenic aerosols are a major factor contributing to human-induced climate change, particularly over the densely populated Asian monsoon region. Understanding the physical processes controlling the aerosol-induced changes in monsoon rainfall is essential for reducing the uncertainties in the future projections of the hydrological cycle. Here we use multiple coupled and atmospheric general circulation models to explore the physical mechanisms for the aerosol-driven monsoon changes on different time scales. We show that anthropogenic aerosols induce an overall reduction in monsoon rainfall and circulation, which can be largely explained by the fast adjustments over land north of 20∘N. This fast response occurs before changes in sea surface temperature (SST), largely driven by aerosol-cloud interactions. However, aerosol-induced SST feedbacks (slow response) cause substantial changes in the monsoon meridional circulation over the oceanic regions. Both the land-ocean asymmetry and meridional temperature gradient are key factors in determining the overall monsoon circulation response.

A continuum model for pressure-flow relationship in human pulmonary circulation.

PubMed

Huang, Wei; Zhou, Qinlian; Gao, Jian; Yen, R T

2011-06-01

A continuum model was introduced to analyze the pressure-flow relationship for steady flow in human pulmonary circulation. The continuum approach was based on the principles of continuum mechanics in conjunction with detailed measurement of vascular geometry, vascular elasticity and blood rheology. The pulmonary arteries and veins were considered as elastic tubes and the "fifth-power law" was used to describe the pressure-flow relationship. For pulmonary capillaries, the "sheet-flow" theory was employed and the pressure-flow relationship was represented by the "fourth-power law". In this paper, the pressure-flow relationship for the whole pulmonary circulation and the longitudinal pressure distribution along the streamlines were studied. Our computed data showed general agreement with the experimental data for the normal subjects and the patients with mitral stenosis and chronic bronchitis in the literature. In conclusion, our continuum model can be used to predict the changes of steady flow in human pulmonary circulation.

Taking Battery Technology from the Lab to the Big City

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banerjee, Sanjoy; Shmukler, Michael; Martin, Cheryl

2013-07-29

Urban Electric Power, a startup formed by researchers from the City University of New York (CUNY) Energy Institute, is taking breakthroughs in battery technology from the lab to the market. With industry and government funding, including a grant from the Energy Department, Urban Electric Power developed a zinc-nickel oxide battery electrolyte that circulates constantly, eliminating dendrite formation and preventing battery shortages. Their new challenge is to take this technology to the market, where they can scale up the batteries for reducing peak energy demand in urban areas and storing variable renewable electricity.

Taking Battery Technology from the Lab to the Big City

ScienceCinema

Banerjee, Sanjoy; Shmukler, Michael; Martin, Cheryl

2018-02-02

Urban Electric Power, a startup formed by researchers from the City University of New York (CUNY) Energy Institute, is taking breakthroughs in battery technology from the lab to the market. With industry and government funding, including a grant from the Energy Department, Urban Electric Power developed a zinc-nickel oxide battery electrolyte that circulates constantly, eliminating dendrite formation and preventing battery shortages. Their new challenge is to take this technology to the market, where they can scale up the batteries for reducing peak energy demand in urban areas and storing variable renewable electricity.

Cardiac Monitor

NASA Technical Reports Server (NTRS)

1996-01-01

Under contract to Johnson Space Center, the University of Minnesota developed the concept of impedance cardiography as an alternative to thermodilution to access astronaut heart function in flight. NASA then contracted Space Labs, Inc. to construct miniature space units based on this technology. Several companies then launched their own impedance cardiography, including Renaissance Technologies, which manufactures the IQ System. The IQ System is 5 to 17 times cheaper than thermodilution, and features the signal processing technology called TFD (Time Frequency Distribution). TFD provides three- dimensional distribution of the blood circulation force signals, allowing visualization of changes in power, frequency and time.

On the glacial and interglacial thermohaline circulation and the associated transports of heat and freshwater

NASA Astrophysics Data System (ADS)

Ballarotta, M.; Falahat, S.; Brodeau, L.; Döös, K.

2014-11-01

The thermohaline circulation (THC) and the oceanic heat and freshwater transports are essential for understanding the global climate system. Streamfunctions are widely used in oceanography to represent the THC and estimate the transport of heat and freshwater. In the present study, the regional and global changes of the THC, the transports of heat and freshwater and the timescale of the circulation between the Last Glacial Maximum (LGM, ≈ 21 kyr ago) and the present-day climate are explored using an Ocean General Circulation Model and streamfunctions projected in various coordinate systems. We found that the LGM tropical circulation is about 10% stronger than under modern conditions due to stronger wind stress. Consequently, the maximum tropical transport of heat is about 20% larger during the LGM. In the North Atlantic basin, the large sea-ice extent during the LGM constrains the Gulf Stream to propagate in a more zonal direction, reducing the transport of heat towards high latitudes by almost 50% and reorganising the freshwater transport. The strength of the Atlantic Meridional Overturning Circulation depends strongly on the coordinate system. It varies between 9 and 16 Sv during the LGM, and between 12 to 19 Sv for the present day. Similar to paleo-proxy reconstructions, a large intrusion of saline Antarctic Bottom Water takes place into the Northern Hemisphere basins and squeezes most of the Conveyor Belt circulation into a shallower part of the ocean. These different haline regimes between the glacial and interglacial period are illustrated by the streamfunctions in latitude-salinity coordinates and thermohaline coordinates. From these diagnostics, we found that the LGM Conveyor Belt circulation is driven by an enhanced salinity contrast between the Atlantic and the Pacific basin. The LGM abyssal circulation lifts and makes the Conveyor Belt cell deviate from the abyssal region, resulting in a ventilated upper layer above a deep stagnant layer, and an Atlantic circulation more isolated from the Pacific. An estimate of the timescale of the circulation reveals a sluggish abyssal circulation during the LGM, and a Conveyor Belt circulation that is more vigorous due to the combination of a stronger wind stress and a shortened circulation route.

Untangling the roles of wind, run-off and tides in Prince William Sound

NASA Astrophysics Data System (ADS)

Colas, François; Wang, Xiaochun; Capet, Xavier; Chao, Yi; McWilliams, James C.

2013-07-01

Prince William Sound (PWS) oceanic circulation is driven by a combination of local wind, large run-off and strong tides. Using a regional oceanic model of the Gulf of Alaska, adequately resolving the mean circulation and mesoscale eddies, we configure a series of three nested domains. The inner domain zooms in on Prince William Sound with a 1-km horizontal grid resolution. We analyze a set of four experiments with different combinations of run-off, wind and tides to demonstrate the relative influence of these forcing on the central Sound mean circulation cell and its seasonal variability. The mean circulation in the central PWS region is generally characterized by a cyclonic cell. When forced only by the wind, the circulation is cyclonic in winter and fall and strongly anticyclonic in summer. The addition of freshwater run-off greatly enhances the eddy kinetic energy in PWS partly through near-surface baroclinic instabilities. This leads to a much more intermittent circulation in the central Sound, with the presence of intense small-scale turbulence and a disappearance of the summer wind-forced anticyclonic cell. The addition of tides reduces the turbulence intensity (relatively to the experiment with run-off only), particularly in the central Sound. The generation of turbulent motions by baroclinic processes is lowered by tidal mixing and by modification of the exchange at Hinchinbrook Entrance. Tides have an overall stabilizing effect on the central Sound circulation. Tidal rectification currents help maintain a mean cyclonic circulation throughout the year.

The Mars Dust Cycle: Investigating the Effects of Radiatively Active Water Ice Clouds on Surface Stresses and Dust Lifting Potential with the NASA Ames Mars General Circulation Model

NASA Technical Reports Server (NTRS)

Kahre, Melinda A.; Hollingsworth, Jeffery

2012-01-01

The dust cycle is a critically important component of Mars' current climate system. Dust is present in the atmosphere of Mars year-round but the dust loading varies with season in a generally repeatable manner. Dust has a significant influence on the thermal structure of the atmosphere and thus greatly affects atmospheric circulation. The dust cycle is the most difficult of the three climate cycles (CO2, water, and dust) to model realistically with general circulation models. Until recently, numerical modeling investigations of the dust cycle have typically not included the effects of couplings to the water cycle through cloud formation. In the Martian atmosphere, dust particles likely provide the seed nuclei for heterogeneous nucleation of water ice clouds. As ice coats atmospheric dust grains, the newly formed cloud particles exhibit different physical and radiative characteristics. Thus, the coupling between the dust and water cycles likely affects the distributions of dust, water vapor and water ice, and thus atmospheric heating and cooling and the resulting circulations. We use the NASA Ames Mars GCM to investigate the effects of radiatively active water ice clouds on surface stress and the potential for dust lifting. The model includes a state-of-the-art water ice cloud microphysics package and a radiative transfer scheme that accounts for the radiative effects of CO2 gas, dust, and water ice clouds. We focus on simulations that are radiatively forced by a prescribed dust map, and we compare simulations that do and do not include radiatively active clouds. Preliminary results suggest that the magnitude and spatial patterns of surface stress (and thus dust lifting potential) are substantial influenced by the radiative effects of water ice clouds.

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.

PubMed

van der Lee, Sven J; Teunissen, Charlotte E; Pool, René; Shipley, Martin J; Teumer, Alexander; Chouraki, Vincent; Melo van Lent, Debora; Tynkkynen, Juho; Fischer, Krista; Hernesniemi, Jussi; Haller, Toomas; Singh-Manoux, Archana; Verhoeven, Aswin; Willemsen, Gonneke; de Leeuw, Francisca A; Wagner, Holger; van Dongen, Jenny; Hertel, Johannes; Budde, Kathrin; Willems van Dijk, Ko; Weinhold, Leonie; Ikram, M Arfan; Pietzner, Maik; Perola, Markus; Wagner, Michael; Friedrich, Nele; Slagboom, P Eline; Scheltens, Philip; Yang, Qiong; Gertzen, Robert E; Egert, Sarah; Li, Shuo; Hankemeier, Thomas; van Beijsterveldt, Catharina E M; Vasan, Ramachandran S; Maier, Wolfgang; Peeters, Carel F W; Jörgen Grabe, Hans; Ramirez, Alfredo; Seshadri, Sudha; Metspalu, Andres; Kivimäki, Mika; Salomaa, Veikko; Demirkan, Ayşe; Boomsma, Dorret I; van der Flier, Wiesje M; Amin, Najaf; van Duijn, Cornelia M

2018-06-01

Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions. We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifestyle factors (N = 5168) were examined. We discovered and replicated 15 metabolites associated with cognition including subfractions of high-density lipoprotein, docosahexaenoic acid, ornithine, glutamine, and glycoprotein acetyls. These associations were independent of classical risk factors including high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, and apolipoprotein E (APOE) genotypes. Six of the cognition-associated metabolites were related to the risk of dementia and lifestyle factors. Circulating metabolites were consistently associated with cognition, dementia, and lifestyle factors, opening new avenues for prevention of cognitive decline and dementia. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Secondary Gravity Waves in the Winter Mesosphere: Results From a High-Resolution Global Circulation Model

NASA Astrophysics Data System (ADS)

Becker, Erich; Vadas, Sharon L.

2018-03-01

This study analyzes a new high-resolution general circulation model with regard to secondary gravity waves in the mesosphere during austral winter. The model resolves gravity waves down to horizontal and vertical wavelengths of 165 and 1.5 km, respectively. The resolved mean wave drag agrees well with that from a conventional model with parameterized gravity waves up to the midmesosphere in winter and up to the upper mesosphere in summer. About half of the zonal-mean vertical flux of westward momentum in the southern winter stratosphere is due to orographic gravity waves. The high intermittency of the primary orographic gravity waves gives rise to secondary waves that result in a substantial eastward drag in the winter mesopause region. This induces an additional eastward maximum of the mean zonal wind at z ˜ 100 km. Radar and lidar measurements at polar latitudes and results from other high-resolution global models are consistent with this finding. Hence, secondary gravity waves may play a significant role in the general circulation of the winter mesopause region.

Low helium flux from the mantle inferred from simulations of oceanic helium isotope data

NASA Astrophysics Data System (ADS)

Bianchi, Daniele; Sarmiento, Jorge L.; Gnanadesikan, Anand; Key, Robert M.; Schlosser, Peter; Newton, Robert

2010-09-01

The high 3He/ 4He isotopic ratio of oceanic helium relative to the atmosphere has long been recognized as the signature of mantle 3He outgassing from the Earth's interior. The outgassing flux of helium is frequently used to normalize estimates of chemical fluxes of elements from the solid Earth, and provides a strong constraint to models of mantle degassing. Here we use a suite of ocean general circulation models and helium isotope data obtained by the World Ocean Circulation Experiment to constrain the flux of helium from the mantle to the oceans. Our results suggest that the currently accepted flux is overestimated by a factor of 2. We show that a flux of 527 ± 102 mol year - 1 is required for ocean general circulation models that produce distributions of ocean ventilation tracers such as radiocarbon and chlorofluorocarbons that match observations. This new estimate calls for a reevaluation of the degassing fluxes of elements that are currently tied to the helium fluxes, including noble gases and carbon dioxide.

Troposphere-stratosphere (surface-55 km) monthly winter general circulation statistics for the Northern Hemisphere Interannual variations

NASA Technical Reports Server (NTRS)

Geller, M. A.; Wu, M.-F.; Gelman, M. E.

1984-01-01

Individual monthly mean general circulation statistics for the Northern Hemisphere winters of 1978-79, 1979-80, 1980-81, and 1981-82 are examined for the altitude region from the earth's surface to 55 km. Substantial interannual variability is found in the mean zonal geostrophic wind; planetary waves with zonal wavenumber one and two; the heat and momentum fluxes; and the divergence of the Eliassen-Palm flux. These results are compared with previous studies by other workers. This variability in the monthly means is examined further by looking at both time-latitude sections at constant pressure levels and time-height sections at constant latitudes. The implications of this interannual variability for verifying models and interpreting observations are discussed.

The Venus nitric oxide night airglow - Model calculations based on the Venus Thermospheric General Circulation Model

NASA Technical Reports Server (NTRS)

Bougher, S. W.; Gerard, J. C.; Stewart, A. I. F.; Fesen, C. G.

1990-01-01

The mechanism responsible for the Venus nitric oxide (0,1) delta band nightglow observed in the Pioneer Venus Orbiter UV spectrometer (OUVS) images was investigated using the Venus Thermospheric General Circulation Model (Dickinson et al., 1984), modified to include simple odd nitrogen chemistry. Results obtained for the solar maximum conditions indicate that the recently revised dark-disk average NO intensity at 198.0 nm, based on statistically averaged OUVS measurements, can be reproduced with minor modifications in chemical rate coefficients. The results imply a nightside hemispheric downward N flux of (2.5-3) x 10 to the 9th/sq cm sec, corresponding to the dayside net production of N atoms needed for transport.

Interpretation of snow-climate feedback as produced by 17 general circulation models

NASA Technical Reports Server (NTRS)

Cess, R. D.; Zhang, M.-H.; Potter, G. L.; Blanchet, J.-P.; Chalita, S.; Colman, R.; Dazlich, D. A.; Del Genio, A. D.; Lacis, A. A.; Dymnikov, V.

1991-01-01

Snow feedback is expected to amplify global warming caused by increasing concentrations of atmospheric greenhouse gases. The conventional explanation is that a warmer earth will have less snow cover, resulting in a darker planet that absorbs more solar radiation. An intercomparison of 17 general circulation models, for which perturbations of sea surface temperature were used as a surrogate climate change, suggests that this explanation is overly simplistic. The results instead indicate that additional amplification or moderation may be caused both by cloud interactions and longwave radiation. One measure of this net effect of snow feedback was found to differ markedly among the 17 climate models, ranging from weak negative feedback in some models to strong positive feedback in others.

40 CFR 222.3 - Notice of applications.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Contents. Notice of every complete application for a general, special, emergency and research permit shall...—(1)(1) Special and research permits. Notice of every complete application for special and research permits shall be given by: (i) Publication in a daily newspaper of general circulation in the State in...

40 CFR 222.3 - Notice of applications.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Contents. Notice of every complete application for a general, special, emergency and research permit shall...—(1)(1) Special and research permits. Notice of every complete application for special and research permits shall be given by: (i) Publication in a daily newspaper of general circulation in the State in...

The Effect of Surface Ice and Topography on the Atmospheric Circulation and Distribution of Nitrogen Ice on Pluto

NASA Astrophysics Data System (ADS)

Rafkin, Scot C. R.; Soto, Alejandro; Michaels, Timothy I.

2016-10-01

A newly developed general circulation model (GCM) for Pluto is used to investigate the impact of a heterogeneous distribution of nitrogen surface ice and large scale topography on Pluto's atmospheric circulation. The GCM is based on the GFDL Flexible Modeling System (FSM). Physics include a gray model radiative-conductive scheme, subsurface conduction, and a nitrogen volatile cycle. The radiative-conductive model takes into account the 2.3, 3.3 and 7.8 μm bands of CH4 and CO, including non-local thermodynamic equilibrium effects. including non-local thermodynamic equilibrium effects. The nitrogen volatile cycle is based on a vapor pressure equilibrium assumption between the atmosphere and surface. Prior to the arrival of the New Horizons spacecraft, the expectation was that the volatile ice distribution on the surface of Pluto would be strongly controlled by the latitudinal temperature gradient. If this were the case, then Pluto would have broad latitudinal bands of both ice covered surface and ice free surface, as dictated by the season. Further, the circulation, and the thus the transport of volatiles, was thought to be driven almost exclusively by sublimation and deposition flows associated with the volatile cycle. In contrast to expectations, images from New Horizon showed an extremely complex, heterogeneous distribution of surface ices draped over substantial and variable topography. To produce such an ice distribution, the atmospheric circulation and volatile transport must be more complex than previously envisioned. Simulations where topography, surface ice distributions, and volatile cycle physics are added individually and in various combinations are used to individually quantify the importance of the general circulation, topography, surface ice distributions, and condensation flows. It is shown that even regional patches of ice or large craters can have global impacts on the atmospheric circulation, the volatile cycle, and hence, the distribution of surface ices. The work demonstrates that explaining Pluto's volatile cycle and the expression of that cycle in the surface ice distributions requires consideration of atmospheric processes beyond simple vapor pressure equilibrium arguments.

Wave-mean flow interactions in the upper atmosphere

NASA Technical Reports Server (NTRS)

Lindzen, R. S.

1973-01-01

The nature of internal gravity waves is described with special emphasis on their ability to transport energy and momentum. The conditions under which these fluxes interact with the mean state of the atmosphere are described and the results are applied to various problems of the upper atmosphere, including the quasi-biennial oscillation, the heat budget of the thermosphere, the general circulation of the mesosphere, turbulence in the mesosphere, and the 4-day circulation of the Venusian atmosphere.

The Sensitivity of Atlantic Meridional Overturning Circulation to Dynamical Framework in an Ocean General Circulation Model

NASA Astrophysics Data System (ADS)

Li, X.; Yu, Y.

2016-12-01

The horizontal coordinate systems commonly used in most global ocean models are the sphere latitude-longitude grid and displaced poles such as tripolar grid. The effect of the horizontal coordinate system on Atlantic Meridional Overturning Circulation (AMOC) is evaluated using an oceanic general circulation model (OGCM). Two experiments are conducted with the model using latitude-longitude grid (Lat_1) and tripolar grid (Tri). Results show that Tri simulates a stronger NADW than Lat_1, as more saline water masses enter into the GIN Seas in Tri. Two reasons can be attributed to the stronger NADW. One is the removal of zonal filter in Tri, which leads to an increasing of zonal gradient of temperature and salinity, thus strengthens the north geostrophic flow. In turn, it decreases the positive subsurface temperature and salinity biases in the subtropical regions. The other may be associated with topography at the North Pole, because the realistic topography is applied in tripolar grid and the longitude-latitude grid employs an artificial island around the North Pole. In order to evaluate the effect of filter on AMOC, three enhanced filter experiments are carried out. Compared to Lat_1, enhanced filter can also increase the NADW, for more saline water is suppressed to go north and accumulated in the Labrador Sea, especially in the experiment with enhanced filter on salinity (Lat_2_S).

Nonhydrostatic icosahedral atmospheric model (NICAM) for global cloud resolving simulations

NASA Astrophysics Data System (ADS)

Satoh, M.; Matsuno, T.; Tomita, H.; Miura, H.; Nasuno, T.; Iga, S.

2008-03-01

A new type of ultra-high resolution atmospheric global circulation model is developed. The new model is designed to perform "cloud resolving simulations" by directly calculating deep convection and meso-scale circulations, which play key roles not only in the tropical circulations but in the global circulations of the atmosphere. Since cores of deep convection have a few km in horizontal size, they have not directly been resolved by existing atmospheric general circulation models (AGCMs). In order to drastically enhance horizontal resolution, a new framework of a global atmospheric model is required; we adopted nonhydrostatic governing equations and icosahedral grids to the new model, and call it Nonhydrostatic ICosahedral Atmospheric Model (NICAM). In this article, we review governing equations and numerical techniques employed, and present the results from the unique 3.5-km mesh global experiments—with O(10 9) computational nodes—using realistic topography and land/ocean surface thermal forcing. The results show realistic behaviors of multi-scale convective systems in the tropics, which have not been captured by AGCMs. We also argue future perspective of the roles of the new model in the next generation atmospheric sciences.

Visitor circulation and nonhuman animal welfare: an overlooked variable?

PubMed

Davey, Gareth; Henzi, Peter

2004-01-01

This article investigates visitor circulation and behaviors within a gallery of primate exhibits in relation to their possible implications for nonhuman animal welfare. When entering a primate house, the majority of visitors (84%) turned right, a pattern upheld throughout all times of the day. These findings demonstrate the existence of the "right-turn" principle, a concept previously identified and investigated in the museum setting. The existence of this circulation pattern in zoos has important implications for the practical management of animal welfare issues because unbalanced or large numbers of visitors at specific enclosures could present a stressful influence. The "direction bias" could not be attributed to demographic or behavioral traits, therefore suggesting that the principle, like similar findings from museum research, generalizes across visitor populations and, therefore, zoos. A visitor sample at another exhibit (located outside the exhibit gallery) did not display a direction bias, suggesting that the marked circulation pattern may be specific to exhibit galleries. The article discusses the significance and consequences of visitor circulation with respect to visitor management and animal welfare.

Past Asian Monsoon circulation from multiple tree-ring proxies and models (Invited)

NASA Astrophysics Data System (ADS)

Anchukaitis, K. J.; Herzog, M.; Hernandez, M.; Martin-Benito, D.; Gagen, M.; LeGrande, A. N.; Ummenhofer, C.; Buckley, B.; Cook, E. R.

2013-12-01

The Asian monsoon can be characterized in terms of precipitation variability as well as features of regional atmospheric circulation across a range of spatial and temporal scales. While multicentury time series of tree-ring widths at hundreds of sites across Asia provide estimates of past rainfall, the oxygen isotope ratios of annual rings at some of these sites can reveal broader regional atmosphere-ocean dynamics. Here we present a replicated, multicentury stable isotope series from Vietnam that integrates the influence of monsoon circulation on water isotopes. Stronger (weaker) monsoon flow over Indochina is associated with lower (higher) oxygen isotope values in our long-lived tropical conifers. Ring width and isotopes show particular coherence at multidecadal time scales, and together allow past precipitation amount and circulation strength to be disentangled. Combining multiple tree-ring proxies with simulations from isotope-enabled and paleoclimate general circulation models allows us to independently assess the mechanisms responsible for proxy formation and to evaluate how monsoon rainfall is influenced by ocean-atmosphere interactions at timescales from interannual to multidecadal.

Effect of potential vorticity flux on the circulation in the South China Sea

NASA Astrophysics Data System (ADS)

Zhu, Yaohua; Sun, Junchuan; Wang, Yonggang; Wei, Zexun; Yang, Dezhou; Qu, Tangdong

2017-08-01

This study analyzes temperature and salinity products from the U.S. Navy Generalized Digital Environment Model. To avoid the fictitious assumption of no-motion reference level, a P-vector inverse method is employed to derive geostrophic velocity. Line integral of geostrophic velocity shows evidence for the existence of a sandwiched circulation in the South China Sea (SCS), i.e., cyclonic circulation in the subsurface and deep layers and anticyclonic in the intermediate layer. To reveal the factors responsible for the sandwiched circulation, we derive the potential vorticity equation based on a four-and-a-half-layer quasi-geostrophic model and apply theoretical potential vorticity constraint to density layers. The result shows that the sandwiched circulation is largely induced by planetary potential vorticity flux through lateral boundaries, mainly the Luzon Strait. This dynamical mechanism lies in the fact that the net potential vorticity inflow in the subsurface and deep layers leads to a positive layer-average vorticity in the SCS basin, yielding vortex stretching and a cyclonic basin-wide circulation. On the contrary, the net potential vorticity outflow in the intermediate layer induces a negative layer-average vorticity, generating an anticyclonic basin-wide circulation in the SCS. Furthermore, by illustrating different consequence from depth/density layers, we clarify that density layers are essential for applying theoretical potential vorticity constraint to the isolated deep SCS basin.

The impact of circulation control on rotary aircraft controls systems

NASA Technical Reports Server (NTRS)

Kingloff, R. F.; Cooper, D. E.

1987-01-01

Application of circulation to rotary wing systems is a new development. Efforts to determine the near and far field flow patterns and to analytically predict those flow patterns have been underway for some years. Rotary wing applications present a new set of challenges in circulation control technology. Rotary wing sections must accommodate substantial Mach number, free stream dynamic pressure and section angle of attack variation at each flight condition within the design envelope. They must also be capable of short term circulation blowing modulation to produce control moments and vibration alleviation in addition to a lift augmentation function. Control system design must provide this primary control moment, vibration alleviation and lift augmentation function. To accomplish this, one must simultaneously control the compressed air source and its distribution. The control law algorithm must therefore address the compressor as the air source, the plenum as the air pressure storage and the pneumatic flow gates or valves that distribute and meter the stored pressure to the rotating blades. Also, mechanical collective blade pitch, rotor shaft angle of attack and engine power control must be maintained.

On the Origin of Monsoon

NASA Technical Reports Server (NTRS)

Chao, Winston C.; Chen, Baode; Einaudi, Franco (Technical Monitor)

2000-01-01

It is a long-held fundamental belief that the basic cause of a monsoon is land-sea thermal contrast on the continental scale. Through general circulation model experiments we demonstrate that this belief should be changed. The Asian and Australian summer monsoon circulations are largely intact in an experiment in which Asia, maritime continent, and Australia are replaced by ocean. It is also shown that the change resulting from such replacement is in general due more to the removal of topography than to the removal of land-sea contrast. Therefore, land-sea contrast plays only a minor modifying role in Asian and Australian summer monsoons. This also happens to the Central American summer monsoon. However, the same thing cannot be said of the African and South American summer monsoons. In Asian and Australian winter monsoons land-sea contrast also plays only a minor role. Our interpretation for the origin of monsoon is that the summer monsoon is the result of ITCZ's (intertropical convergence zones) peak being substantially (more than 10 degrees) away from the equator. The origin of the ITCZ has been previously interpreted by Chao. The circulation around thus located ITCZ, previously interpreted by Chao and Chen through the modified Gill solution and briefly described in this paper, explains the monsoon circulation. The longitudinal location of the ITCZs is determined by the distribution of surface conditions. ITCZ's favor locations of higher SST as in western Pacific and Indian Ocean, or tropical landmass, due to land-sea contrast, as in tropical Africa and South America. Thus, the role of landmass in the origin of monsoon can be replaced by ocean of sufficiently high SST. Furthermore, the ITCZ circulation extends into the tropics in the other hemisphere to give rise to the winter monsoon circulation there. Also through the equivalence of land-sea contrast and higher SST, it is argued that the basic monsoon onset mechanism proposed by Chao is valid for all monsoons.

Results of various studies made with the NCAR Thermospheric General Circulation Model (TGCM) (invited review)

NASA Technical Reports Server (NTRS)

Roble, R. G.

1986-01-01

The NCAR thermospheric general circulation model (TGCM) has been used for a variety of thermospheric dynamic studies. It has also been used to compare model predictions with measurements made from various ground-based Fabry-Perot interferometer stations, incoherent scatter radar stations and the Dynamics Explorer satellites. The various input and output features of the model are described. These include the specification of solar EUV fluxes, and descriptions of empirical models to specify auroral particle precipitation, ion drag, and magnetospheric convection. Results are presented for solstice conditions giving the model perturbation temperature and circulation response to solar heating forcing alone and also with the inclusion of magnetospheric convections for two different dawn-dusk potential drops, 20 and 60 kV respectively. Results at two constant pressure levels Z =+1 at 300 km and Z= -4 at 120 km are presented for both the winter and summer polar cap regions. The circulation over the Northern Hemisphere polar cap in both the upper and lower thermosphere are presented along with a figure showing that the circulation is mainly a non-divergent irrotational flow responding to ion drag. The results of a study made on the Southern Hemisphere polar cap during October 1981 where Dynamics Explorer satellite measurements of winds, temperature and composition are compared to TGCM predictions are also presented. A diagnostic package that has been developed to analyze the balance of forces operating in the TGCM is presented next illustrating that in the F-region ion drag and pressure provide the main force balance and in the E-region ion drag, pressure and the coriolis forces provide the main balance. The TGCM prediction for the June 10, 1983 total solar eclipse are next presented showing a thermospheric disturbance following the path of totality. Finally, results are presented giving the global circulation, temperature and composition structure of the thermosphere for solar minimum conditions at equinox with 60 kV magnetospheric convection forcing at high latitudes.

Performance of computer vision in vivo flow cytometry with low fluorescence contrast

PubMed Central

Markovic, Stacey; Li, Siyuan; Niedre, Mark

2015-01-01

Abstract. Detection and enumeration of circulating cells in the bloodstream of small animals are important in many areas of preclinical biomedical research, including cancer metastasis, immunology, and reproductive medicine. Optical in vivo flow cytometry (IVFC) represents a class of technologies that allow noninvasive and continuous enumeration of circulating cells without drawing blood samples. We recently developed a technique termed computer vision in vivo flow cytometry (CV-IVFC) that uses a high-sensitivity fluorescence camera and an automated computer vision algorithm to interrogate relatively large circulating blood volumes in the ear of a mouse. We detected circulating cells at concentrations as low as 20  cells/mL. In the present work, we characterized the performance of CV-IVFC with low-contrast imaging conditions with (1) weak cell fluorescent labeling using cell-simulating fluorescent microspheres with varying brightness and (2) high background tissue autofluorescence by varying autofluorescence properties of optical phantoms. Our analysis indicates that CV-IVFC can robustly track and enumerate circulating cells with at least 50% sensitivity even in conditions with two orders of magnitude degraded contrast than our previous in vivo work. These results support the significant potential utility of CV-IVFC in a wide range of in vivo biological models. PMID:25822954

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salnykov, A. A., E-mail: admin@rasnpp.org.ru

A method for predicting operating technological failures in nuclear power plants which makes it possible to reduce the unloading of the generator unit during the onset and development of an anomalous engineering state of the equipment by detecting a change in state earlier and taking suitable measures. With the circulating water supply loop of a nuclear power plant as an example, scenarios and algorithms for predicting technological failures in the operation of equipment long before their actual occurrence are discussed.

Restoration of metal properties of circulation pump blades by the method of surface ultrasonic impact treatment

NASA Astrophysics Data System (ADS)

Povarov, V. P.; Urazov, O. V.; Bakirov, M. B.; Pakhomov, S. S.; Belunik, I. A.

2017-10-01

During the transition period to a market economy, the works producing equipment for the nuclear industry became lame duck companies. The market of heavy industry equipment reduced dramatically, and quality control requirements imposed to goods became lower. Deviations from regulations' requirements and technical specifications for equipment manufacture results in inevitable decrease of reliability during operation but also to failure during check tests. It is not always possible to replace promptly ill-conditioned equipment; in such cases, it is necessary to carry out compensatory measures for restoring working properties up to an acceptable level in order to ensure operational reliability due to the strength improvement of the components of machines and constructions during the whole service life or up to the scheduled date of equipment replacement. This paper is dedicated to development and practical implementation of restorative technology of strengthening ultrasonic treatment used for the metal of the blades of impellers of 16DPA10-28 circulation pumps of 10URS unit pump station located at Novovoronezh NPP-2. The dynamic surface treatment was implemented for compensating the technological defects of the metal of blades. It was revealed that the impact elastic-plastic deformation has a comprehensive compensation effect on the metal of blades in the initial state of delivery and creates the surface-strengthening layer with higher strength properties (strain hardening) of the depth up to 1.5 mm. The surface strain hardening increases the cyclic strength, re-distributes beneficially the residual technological and repair stresses, and heals small surface cracks improving the surface quality. The developed technology was used for treatment of 32 blades of impellers of 10PAC01AP001, 10PAC02AP001, 10PAC03AP001, 10PAC04AP001 circulation pumps. The implemented 100-h full-scale test of the pumps revealed the high efficiency of the developed technology and made it possible to recommend it for application at both the stage of blade manufacture and during the pump operation for prolongation of their service life.

21 CFR 878.5910 - Pneumatic tourniquet.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5910 Pneumatic tourniquet... patient's limb and inflated to reduce or totally occlude circulation during surgery. (b) Classification...

21 CFR 878.5910 - Pneumatic tourniquet.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5910 Pneumatic tourniquet... patient's limb and inflated to reduce or totally occlude circulation during surgery. (b) Classification...

21 CFR 878.5910 - Pneumatic tourniquet.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5910 Pneumatic tourniquet... patient's limb and inflated to reduce or totally occlude circulation during surgery. (b) Classification...

21 CFR 878.5910 - Pneumatic tourniquet.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5910 Pneumatic tourniquet... patient's limb and inflated to reduce or totally occlude circulation during surgery. (b) Classification...

21 CFR 878.5910 - Pneumatic tourniquet.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Therapeutic Devices § 878.5910 Pneumatic tourniquet... patient's limb and inflated to reduce or totally occlude circulation during surgery. (b) Classification...

Liquid Biopsies in the Screening of Oncogenic Mutations in NSCLC and its Application in Targeted Therapy.

PubMed

Tang, Jason H; Chia, David

2015-01-01

Non-small cell lung cancer (NSCLC) still dominates cancer-related deaths in America. Despite this, new discoveries and advancements in technology are helping with the detection and treatment of NSCLC. The discovery of circulating tumor DNA in blood and other biofluids is essential for the creation of a DNA biomarker. Limitations in technology and sequencing have stunted assay development, but with recent advancements in the next-generation sequencing, droplet digital PCR, and EFIRM, the detection of mutations in biofluids has become possible with reasonable sensitivity and specificity. These methods have been applied to the detection of mutations in NSCLC by measuring the levels of circulating tumor DNA. ALK fusion genes along with mutations in EGFR and KRAS have been shown to correlate to tumor size and metastasis. These methods allow for noninvasive, affordable, and efficient diagnoses of oncogenic mutations that overcome the issues of traditional biopsies. These issues include tumor heterogeneity and early detection of cancers with asymptomatic early stages. Early detection and treatment remain the best way to ensure survival. This review aims to describe these new technologies along with their application in mutation detection in NSCLC in order to proactively utilize targeted anticancer therapy.

Do Coupled Climate Models Correctly SImulate the Upward Branch of the Deept Ocean Global Conveyor?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarmiento, Jorge L; Downes, Stephanie; Bianchi, Daniele

The large-scale meridional overturning circulation (MOC) connects the deep ocean, a major reservoir of carbon, to the other components of the climate system and must therefore be accurately represented in Earth System Models. Our project aims to address the specific question of the pathways and mechanisms controlling the upwelling branch of the MOC, a subject of significant disagreement between models and observational syntheses, and among general circulation models. Observations of these pathways are limited, particularly in regions of complex hydrography such as the Southern Ocean. As such, we rely on models to examine theories of the overturning circulation, both physicallymore » and biogeochemically. This grant focused on a particular aspect of the meridional overturning circulation (MOC) where there is currently significant disagreement between models and observationally based analyses of the MOC, and amongst general circulation models. In particular, the research focused on addressing the following questions: 1. Where does the deep water that sinks in the polar regions rise to the surface? 2. What processes are responsible for this rise? 3. Do state-of-the-art coupled GCMs capture these processes? Our research had three key components: observational synthesis, model development and model analysis. In this final report we outline the key results from these areas of research for the 2007 to 2012 grant period. The research described here was carried out primarily by graduate student, Daniele Bianchi (now a Postdoc at McGill University, Canada), and Postdoc Stephanie Downes (now a Research Fellow at The Australian national University, Australia). Additional support was provided for programmers Jennifer Simeon as well as Rick Slater.« less

The impact of oceanic heat transport on the atmospheric circulation

NASA Astrophysics Data System (ADS)

Lucarini, Valerio; Lunkeit, Frank

2017-04-01

A general circulation model of intermediate complexity with an idealized Earth-like aquaplanet setup is used to study the impact of changes in the oceanic heat transport on the global atmospheric circulation. Focus is on the atmospheric mean meridional circulation and global thermodynamic properties. The atmosphere counterbalances to a large extent the imposed changes in the oceanic heat transport, but, nonetheless, significant modifications to the atmospheric general circulation are found. Increasing the strength of the oceanic heat transport up to 2.5 PW leads to an increase in the global mean near-surface temperature and to a decrease in its equator-to-pole gradient. For stronger transports, the gradient is reduced further, but the global mean remains approximately constant. This is linked to a cooling and a reversal of the temperature gradient in the tropics. Additionally, a stronger oceanic heat transport leads to a decline in the intensity and a poleward shift of the maxima of both the Hadley and Ferrel cells. Changes in zonal mean diabatic heating and friction impact the properties of the Hadley cell, while the behavior of the Ferrel cell is mostly controlled by friction. The efficiency of the climate machine, the intensity of the Lorenz energy cycle and the material entropy production of the system decline with increased oceanic heat transport. This suggests that the climate system becomes less efficient and turns into a state of reduced entropy production as the enhanced oceanic transport performs a stronger large-scale mixing between geophysical fluids with different temperatures, thus reducing the available energy in the climate system and bringing it closer to a state of thermal equilibrium.

An Oceanic General Circulation Model (OGCM) investigation of the Red Sea circulation, 1. Exchange between the Red Sea and the Indian Ocean

NASA Astrophysics Data System (ADS)

Sofianos, Sarantis S.; Johns, William E.

2002-11-01

The mechanisms involved in the seasonal exchange between the Red Sea and the Indian Ocean are studied using an Oceanic General Circulation Model (OGCM), namely the Miami Isopycnic Coordinate Ocean Model (MICOM). The model reproduces the basic characteristics of the seasonal circulation observed in the area of the strait of Bab el Mandeb. There is good agreement between model results and available observations on the strength of the exchange and the characteristics of the water masses involved, as well as the seasonal flow pattern. During winter, this flow consists of a typical inverse estuarine circulation, while during summer, the surface flow reverses, there is an intermediate inflow of relatively cold and fresh water, and the hypersaline outflow at the bottom of the strait is significantly reduced. Additional experiments with different atmospheric forcing (seasonal winds, seasonal thermohaline air-sea fluxes, or combinations) were performed in order to assess the role of the atmospheric forcing fields in the exchange flow at Bab el Mandeb. The results of both the wind- and thermohaline-driven experiments exhibit a strong seasonality at the area of the strait, which is in phase with the observations. However, it is the combination of both the seasonal pattern of the wind stress and the seasonal thermohaline forcing that can reproduce the observed seasonal variability at the strait. The importance of the seasonal cycle of the thermohaline forcing on the exchange flow pattern is also emphasized by these results. In the experiment where the thermohaline forcing is represented by its annual mean, the strength of the exchange is reduced almost by half.

Investigating the Climatic Impacts of Globally Shifted Anthropogenic Emissions

NASA Astrophysics Data System (ADS)

Wang, Y.; Jiang, J. H.; Su, H.

2014-12-01

With a quasi-exponential growth in industrialization since the mid-1990s, Asia has undergone a dramatic increase in anthropogenic emissions of aerosol and precursor gases to the atmosphere. Meanwhile, such emissions have been stabilized or reduced over North America and Europe. This geographical shift of global emission sources could potentially perturb the regional and global climate due to impact of aerosols on cloud properties, precipitation, and large-scale circulation. We use an atmospheric general circulation model (AGCM) with different aerosol scenarios to investigate the radiative and microphysical effects of anthropogenic aerosols on the large-scale circulation and regional climate over the globe. We conduct experiments to simulate the continental shift of aerosol distribution by contrasting two simulations using 1970 and 2010 anthropogenic emission sources. We found the elevation of aerosol concentrations in East and South Asia results in regional surface temperature cooling of -0.10° to -0.17°C, respectively, due to the enhanced solar extinction by aerosols and cloud reflectivity. The reduction of the local aerosol loadings in Europe causes a significant warming of +0.4°C. However, despite recent decreasing in aerosol emission, North America shows a cooling of -0.13°C, likely caused by increasing of cloudiness under the influence of modulated general circulation. These aerosol induced temperature changes are consistent with the observed temperature trends from 1980 to 2013 in the reanalysis data. Our study also predicts weaker East/South Asia summer monsoons due to strong regional aerosol forcing. Moreover, the ascending motion in the northern tropics is found to be weakened by asymmetrical aerosol forcing, resulting in the cross-equatorial shift of Hadley Circulation.

The dynamics of the Snowball Earth Hadley circulation for off-equatorial and seasonally varying insolation

NASA Astrophysics Data System (ADS)

Voigt, A.

2013-11-01

I study the Hadley circulation of a completely ice-covered Snowball Earth through simulations with a comprehensive atmosphere general circulation model. Because the Snowball Earth atmosphere is an example of a dry atmosphere, these simulations allow me to test to what extent dry theories and idealized models capture the dynamics of realistic dry Hadley circulations. Perpetual off-equatorial as well as seasonally varying insolation is used, extending a previous study for perpetual on-equatorial (equinox) insolation. Vertical diffusion of momentum, representing the momentum transport of dry convection, is fundamental to the momentum budgets of both the winter and summer cells. In the zonal budget, it is the primary process balancing the Coriolis force. In the meridional budget, it mixes meridional momentum between the upper and the lower branch and thereby decelerates the circulation. Because of the latter, the circulation intensifies by a factor of three when vertical diffusion of momentum is suppressed. For seasonally varying insolation, the circulation undergoes rapid transitions from the weak summer into the strong winter regime. Consistent with previous studies in idealized models, these transitions result from a mean-flow feedback, because of which they are insensitive to the treatment of vertical diffusion of momentum. Overall, the results corroborate previous findings for perpetual on-equatorial insolation. They demonstrate that descriptions of realistic dry Hadley circulations, in particular their strength, need to incorporate the vertical momentum transport by dry convection, a process that is neglected in most dry theories and idealized models. An improved estimate of the strength of the Snowball Earth Hadley circulation will also help to better constrain the climate of a possible Neoproterozoic Snowball Earth and its deglaciation threshold.

The dynamics of the Snowball Earth Hadley circulation for off-equatorial and seasonally-varying insolation

NASA Astrophysics Data System (ADS)

Voigt, A.

2013-08-01

I study the Hadley circulation of a completely ice-covered Snowball Earth through simulations with a comprehensive atmosphere general circulation model. Because the Snowball Earth atmosphere is an example of a dry atmosphere, these simulations allow me to test to what extent dry theories and idealized models capture the dynamics of dry Hadley circulations. Perpetual off-equatorial as well as seasonally-varying insolation is used, extending a previous study for perpetual on-equatorial (equinox) insolation. Vertical diffusion of momentum, representing the momentum transport of dry convection, is fundamental to the momentum budgets of both the winter and summer cells. In the zonal budget, it is the primary process balancing the Coriolis force. In the meridional budget, it mixes meridional momentum between the upper and the lower branch and thereby decelerates the circulation. Because of the latter, the circulation intensifies by a factor of three when vertical diffusion of momentum is suppressed. For seasonally-varying insolation, the circulation undergoes rapid transitions from the weak summer into the strong winter regime. Consistent with previous studies in idealized models, these transitions result from a mean-flow feedback, because of which they are insensitive to the treatment of vertical diffusion of momentum. Overall, the results corroborate previous findings for perpetual on-equatorial insolation. They demonstrate that an appropriate description of dry Hadley circulations, in particular their strength, needs to incorporate the vertical momentum transport by dry convection, a process that is neglected in most dry theories and idealized models. An improved estimate of the strength of the Snowball Earth Hadley circulation will also help to better constrain the climate of a possible Neoproterozoic Snowball Earth and its deglaciation threshold.

Forcing mechanism of the seasonally asymmetric quasi-biennial oscillation secondary circulation in ERA-40 and MAECHAM5

NASA Astrophysics Data System (ADS)

Peña-Ortiz, C.; Ribera, P.; García-Herrera, R.; Giorgetta, M. A.; García, R. R.

2008-08-01

The seasonality of the quasi-biennial oscillation (QBO) and its secondary circulation is analyzed in the European Reanalysis (ERA-40) and Middle Atmosphere European Centre Hamburg Model (MAECHAM5) general circulation model data sets through the multitaper method-singular value decomposition (MTM-SVD). In agreement with previous studies, the results reveal a strong seasonal dependence of the QBO secondary circulation. This is characterized by a two-cell structure symmetric about the equator during autumn and spring. However, anomalies strongly weaken in the summer hemisphere and strengthen in the winter hemisphere, leading to an asymmetric QBO secondary circulation characterized by a single-cell structure displaced into the winter hemisphere during the solstices. In ERA-40, this asymmetry is more pronounced during the northern than during the southern winter. These results provide the first observation of the QBO secondary circulation asymmetries in the ERA-40 reanalysis data set across the full stratosphere and the lower mesosphere, up to 0.1 hPa. The MTM-SVD reconstruction of the seasonal QBO signals in the residual circulation and the QBO signals in Eliassen Palm (EP) flux divergences suggest a particular mechanism for the seasonal asymmetries of the QBO secondary circulation and its extension across the midlatitudes. The analysis shows that the QBO modulates the EP flux in the winter hemispheric surf zone poleward of the QBO jets. The zonal wind forcing by EP flux divergence is transformed by the Coriolis effect into a meridional wind signal. The seasonality in the stratospheric EP flux and the hemispheric differences in planetary wave forcing cause the observed seasonality in the QBO secondary circulation and its hemispheric differences.

Does coupled ocean enhance ozone-hole-induced Southern Hemisphere circulation changes?

NASA Astrophysics Data System (ADS)

Son, S. W.; Han, B. R.; Kim, S. Y.; Park, R.

2017-12-01

The ozone-hole-induced Southern Hemisphere (SH) circulation changes, such as poleward shift of westerly jet and Hadley cell widening, have been typically explored with either coupled general circulation models (CGCMs) prescribing stratospheric ozone or chemistry-climate models (CCMs) prescribing surface boundary conditions. Only few studies have utilized ocean-coupled CCMs with a relatively coarse resolution. To better quantify the role of interactive chemistry and coupled ocean in the ozone-hole-induced SH circulation changes, the present study examines a set of CGCM and CCM simulations archived for the Coupled Model Intercomparison Project phase 5 (CMIP5) and CCM initiative (CCMI). Although inter-model spread of Antarctic ozone depletion is substantially large especially in the austral spring, both CGCMs with relatively simple ozone chemistry and CCMs with fully interactive comprehensive chemistry reasonably well reproduce long-term trends of Antarctic ozone and the associated polar-stratospheric temperature changes. Most models reproduce a poleward shift of SH jet and Hadley-cell widening in the austral summer in the late 20th century as identified in reanalysis datasets. These changes are quasi-linearly related with Antarctic ozone changes, confirming the critical role of Antarctic ozone depletion in the austral-summer zonal-mean circulation changes. The CGCMs with simple but still interactive ozone show slightly stronger circulation changes than those with prescribed ozone. However, the long-term circulation changes in CCMs are largely insensitive to the coupled ocean. While a few models show the enhanced circulation changes when ocean is coupled, others show essentially no changes or even weakened circulation changes. This result suggests that the ozone-hole-related stratosphere-troposphere coupling in the late 20th century may be only weakly sensitive to the coupled ocean.

Moral maps and medical imaginaries: clinical tourism at Malawi's College of Medicine.

PubMed

Wendland, Claire L

2012-01-01

At an understaffed and underresourced urban African training hospital, Malawian medical students learn to be doctors while foreign medical students, visiting Malawi as clinical tourists on short-term electives, learn about “global health.” Scientific ideas circulate fast there; clinical tourists circulate readily from outside to Malawi but not the reverse; medical technologies circulate slowly, erratically, and sometimes not at all. Medicine's uneven globalization is on full display. I extend scholarship on moral imaginations and medical imaginaries to propose that students map these wards variously as places in which—or from which—they seek a better medicine. Clinical tourists, enacting their own moral maps, also become representatives of medicine “out there”: points on the maps of others. Ethnographic data show that for Malawians, clinical tourists are colleagues, foils against whom they construct ideas about a superior and distinctly Malawian medicine and visions of possible alternative futures for themselves.

Cytomorphology of Circulating Colorectal Tumor Cells:A Small Case Series

PubMed Central

Marrinucci, Dena; Bethel, Kelly; Lazar, Daniel; Fisher, Jennifer; Huynh, Edward; Clark, Peter; Bruce, Richard; Nieva, Jorge; Kuhn, Peter

2010-01-01

Several methodologies exist to enumerate circulating tumor cells (CTCs) from the blood of cancer patients; however, most methodologies lack high-resolution imaging, and thus, little is known about the cytomorphologic features of these cells. In this study of metastatic colorectal cancer patients, we used immunofluorescent staining with fiber-optic array scanning technology to identify CTCs, with subsequent Wright-Giemsa and Papanicolau staining. The CTCs were compared to the corresponding primary and metastatic tumors. The colorectal CTCs showed marked intrapatient pleomorphism. In comparison to the corresponding tissue biopsies, cells from all sites showed similar pleomorphism, demonstrating that colorectal CTCs retain the pleomorphism present in regions of solid growth. They also often retain particular cytomorphologic features present in the patient's primary and/or metastatic tumor tissue. This study provides an initial analysis of the cytomorphologic features of circulating colon cancer cells, providing a foundation for further investigation into the significance and metastatic potential of CTCs. PMID:20111743

Cardiac arrest: resuscitation and reperfusion.

PubMed

Patil, Kaustubha D; Halperin, Henry R; Becker, Lance B

2015-06-05

The modern treatment of cardiac arrest is an increasingly complex medical procedure with a rapidly changing array of therapeutic approaches designed to restore life to victims of sudden death. The 2 primary goals of providing artificial circulation and defibrillation to halt ventricular fibrillation remain of paramount importance for saving lives. They have undergone significant improvements in technology and dissemination into the community subsequent to their establishment 60 years ago. The evolution of artificial circulation includes efforts to optimize manual cardiopulmonary resuscitation, external mechanical cardiopulmonary resuscitation devices designed to augment circulation, and may soon advance further into the rapid deployment of specially designed internal emergency cardiopulmonary bypass devices. The development of defibrillation technologies has progressed from bulky internal defibrillators paddles applied directly to the heart, to manually controlled external defibrillators, to automatic external defibrillators that can now be obtained over-the-counter for widespread use in the community or home. But the modern treatment of cardiac arrest now involves more than merely providing circulation and defibrillation. As suggested by a 3-phase model of treatment, newer approaches targeting patients who have had a more prolonged cardiac arrest include treatment of the metabolic phase of cardiac arrest with therapeutic hypothermia, agents to treat or prevent reperfusion injury, new strategies specifically focused on pulseless electric activity, which is the presenting rhythm in at least one third of cardiac arrests, and aggressive post resuscitation care. There are discoveries at the cellular and molecular level about ischemia and reperfusion pathobiology that may be translated into future new therapies. On the near horizon is the combination of advanced cardiopulmonary bypass plus a cocktail of multiple agents targeted at restoration of normal metabolism and prevention of reperfusion injury, as this holds the promise of restoring life to many patients for whom our current therapies fail. © 2015 American Heart Association, Inc.

Technology and Microcomputers for an Information Centre/Special Library.

ERIC Educational Resources Information Center

Daehn, Ralph M.

1984-01-01

Discusses use of microcomputer hardware and software, telecommunications methods, and advanced library methods to create a specialized information center's database of literature relating to farm machinery and food processing. Systems and services (electronic messaging, serials control, database creation, cataloging, collections, circulation,…

CFB repowering options

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gittinger, J.

1996-12-31

Circulating fluidized bed CFB repowering options are summarized. The following topics are discussed: why repower with CFB technology; advantages of repowering; two forms of of repowering; B and N`s internal recirculation CFB; space-saving design features; cost-saving design features; Ukrainian repowering project; and candidates for repowering.

"Mobile" Contexts/"Immobile" Cultures

ERIC Educational Resources Information Center

Geoffroy, Christine

2007-01-01

Communication technologies and cheap air travel have profoundly reshaped the patterns of international circulation and migration, blurring the distinction between travellers, tourists and migrants. Some tourists have selected their former recreational area as permanent place of residence while other people are choosing or are being forced into…

[Isn't the heart the source of energy for blood circulation? "The heart doesn't know the basic laws of physics"].

PubMed

Papp, Lajos

2008-08-03

For hundreds of years, universal medical practice has depicted the heart to be the central organ, showing the heart's function as the primary source of energy for blood circulation, paying particular importance to the role of the heart valves. At present the generally accepted paradigm: the main force component of blood circulation is the pressure-gradient generated by the working heart. In serious combined illnesses of heart valves, the function of the valve is almost nonexistent. Based on the value of pressure in the chambers of the heart and in the great arteries and veins, blood flows from a place of high pressure to lower pressure, and should work the other way around as well. It is a fact, however, that even in such cases the circulation of blood is directed from the main arteries towards the veins: without the function of the valves--seemingly opposing the basic laws of physics--it keeps its original direction. Therefore we can justifiably infer that it isn't the work of the heart muscle that provides the source of energy for blood circulation. The heart has an essential function in the maintenance of blood circulation: pulse generation. The principal role of the heart is to generate pulses and not pressure.

Simulation of mesoscale circulation in the Tatar Strait of the Japan Sea

NASA Astrophysics Data System (ADS)

Ponomarev, V. I.; Fayman, P. A.; Prants, S. V.; Budyansky, M. V.; Uleysky, M. Yu.

2018-06-01

The eddy-resolved ocean circulation model RIAMOM (Lee et al., 2003) is used to analyze seasonal variability of mesoscale circulation in the Tatar Strait of the Japan Sea. The model domain is a vast area including the northern Japan Sea, Okhotsk Sea and adjacent region in the Pacific Ocean. A numerical experiment with a horizontal 1/18° resolution has been carried out under realistic meteorological conditions from the ECMWF ERA-40 reanalysis with restoring of surface temperature and salinity. The simulated seasonal variability of both the current system and mesoscale eddy dynamics in the Tatar Strait is in a good agreement with temperature and salinity distributions of oceanographic observation data collected during various seasons and years. Two general circulation regimes in the Strait have been found. The circulation regime changes from summer to winter due to seasonal change of the North Asian Monsoon. On a synoptic time scale, the similar change of the circulation regime occurs due to change of the southeastern wind to the northwestern one when the meteorological situation with an anticyclone over the Okhotsk Sea changes to that with a strong cyclone. The Lagrangian maps illustrate seasonal changes in direction of the main currents and in polarity and location of mesoscale eddies in the Strait.

Simulations of the north sea circulation, its variability, and its implementation as hydrodynamical forcing in ERSEM

NASA Astrophysics Data System (ADS)

Lenhart, Hermann J.; Radach, Günther; Backhaus, Jan O.; Pohlmann, Thomas

The rationale is given of how the gross physical features of the circulation and the stratification of the North Sea have been aggregated for inclusion in the ecosystem box model ERSEM. As the ecosystem dynamics are to a large extent determined by small-scale physical events, the ecosystem model is forced with the circulation of a specific year rather than using the long-term mean circulation field. Especially the vertical exchange processes have been explicitly included, because the primary production strongly depends on them. Simulations with a general circulation model (GCM), forced by three-hourly meteorological fields, have been utilized to derive daily horizontal transport values driving ERSEM on boxes of sizes of a few 100 km. The daily vertical transports across a fixed 30-m interface provide the necessary short-term event character of the vertical exchange. For the years 1988 and 1989 the properties of the hydrodynamic flow fields are presented in terms of trajectories of the flow, thermocline depths, of water budgets, flushing times and diffusion rates. The results of the standard simulation with ERSEM show that the daily variability of the circulation, being smoothed by the box integration procedure, is transferred to the chemical and biological state variables to a very limited degree only.

An Isopycnal Box Model with predictive deep-ocean structure for biogeochemical cycling applications

NASA Astrophysics Data System (ADS)

Goodwin, Philip

2012-07-01

To simulate global ocean biogeochemical tracer budgets a model must accurately determine both the volume and surface origins of each water-mass. Water-mass volumes are dynamically linked to the ocean circulation in General Circulation Models, but at the cost of high computational load. In computationally efficient Box Models the water-mass volumes are simply prescribed and do not vary when the circulation transport rates or water mass densities are perturbed. A new computationally efficient Isopycnal Box Model is presented in which the sub-surface box volumes are internally calculated from the prescribed circulation using a diffusive conceptual model of the thermocline, in which upwelling of cold dense water is balanced by a downward diffusion of heat. The volumes of the sub-surface boxes are set so that the density stratification satisfies an assumed link between diapycnal diffusivity, κd, and buoyancy frequency, N: κd = c/(Nα), where c and α are user prescribed parameters. In contrast to conventional Box Models, the volumes of the sub-surface ocean boxes in the Isopycnal Box Model are dynamically linked to circulation, and automatically respond to circulation perturbations. This dynamical link allows an important facet of ocean biogeochemical cycling to be simulated in a highly computationally efficient model framework.

Can preferred atmospheric circulation patterns over the North-Atlantic-Eurasian region be associated with arctic sea ice loss?

NASA Astrophysics Data System (ADS)

Crasemann, Berit; Handorf, Dörthe; Jaiser, Ralf; Dethloff, Klaus; Nakamura, Tetsu; Ukita, Jinro; Yamazaki, Koji

2017-12-01

In the framework of atmospheric circulation regimes, we study whether the recent Arctic sea ice loss and Arctic Amplification are associated with changes in the frequency of occurrence of preferred atmospheric circulation patterns during the extended winter season from December to March. To determine regimes we applied a cluster analysis to sea-level pressure fields from reanalysis data and output from an atmospheric general circulation model. The specific set up of the two analyzed model simulations for low and high ice conditions allows for attributing differences between the simulations to the prescribed sea ice changes only. The reanalysis data revealed two circulation patterns that occur more frequently for low Arctic sea ice conditions: a Scandinavian blocking in December and January and a negative North Atlantic Oscillation pattern in February and March. An analysis of related patterns of synoptic-scale activity and 2 m temperatures provides a synoptic interpretation of the corresponding large-scale regimes. The regimes that occur more frequently for low sea ice conditions are resembled reasonably well by the model simulations. Based on those results we conclude that the detected changes in the frequency of occurrence of large-scale circulation patterns can be associated with changes in Arctic sea ice conditions.

Experimental Study and CFD Simulation of a 2D Circulating Fluidized Bed

NASA Astrophysics Data System (ADS)

Kallio, S.; Guldén, M.; Hermanson, A.

Computational fluid dynamics (CFD) gains popularity in fluidized bed modeling. For model validation, there is a need of detailed measurements under well-defined conditions. In the present study, experiments were carried out in a 40 em wide and 3 m high 2D circulating fluidized bed. Two experiments were simulated by means of the Eulerian multiphase models of the Fluent CFD software. The vertical pressure and solids volume fraction profiles and the solids circulation rate obtained from the simulation were compared to the experimental results. In addition, lateral volume fraction profiles could be compared. The simulated CFB flow patterns and the profiles obtained from simulations were in general in a good agreement with the experimental results.

Meridional circulation and CNO anomalies in red giant stars

NASA Technical Reports Server (NTRS)

Sweigart, A. V.; Mengel, J. G.

1979-01-01

The possibility is investigated that meridional circulation driven by internal rotation might lead to the mixing of CNO-processed material from the vicinity of the hydrogen shell into the envelope of a red giant star. This theory of meridional mixing is found to be generally consistent with available data and to be capable of explaining a number of observational results without invoking a radical departure from the standard physics of stellar interiors. It is suggested that meridional circulation must be a normal characteristic of a rotating star and that meridional mixing provides a reasonable framework for understanding many of the CNO anomalies exhibited by weak-G-band and CN-strong stars as well as the low C-12/C-13 ratios measured among field red giants.

Investigating Downscaling Methods and Evaluating Climate Models for Use in Estimating Regional Water Resources in Mountainous Regions under Changing Climatic Conditions

NASA Technical Reports Server (NTRS)

Frei, Allan; Nolin, Anne W.; Serreze, Mark C.; Armstrong, Richard L.; McGinnis, David L.; Robinson, David A.

2004-01-01

The purpose of this three-year study is to develop and evaluate techniques to estimate the range of potential hydrological impacts of climate change in mountainous areas. Three main objectives are set out in the proposal. (1) To develop and evaluate transfer functions to link tropospheric circulation to regional snowfall. (2) To evaluate a suite of General Circulation Models (GCMs) for use in estimating synoptic scale circulation and the resultant regional snowfall. And (3) to estimate the range of potential hydrological impacts of changing climate in the two case study areas: the Upper Colorado River basin, and the Catskill Mountains of southeastern New York State. Both regions provide water to large populations.

JIGSAW-GEO (1.0): Locally Orthogonal Staggered Unstructured Grid Generation for General Circulation Modelling on the Sphere

NASA Technical Reports Server (NTRS)

Engwirda, Darren

2017-01-01

An algorithm for the generation of non-uniform, locally orthogonal staggered unstructured spheroidal grids is described. This technique is designed to generate very high-quality staggered VoronoiDelaunay meshes appropriate for general circulation modelling on the sphere, including applications to atmospheric simulation, ocean-modelling and numerical weather prediction. Using a recently developed Frontal-Delaunay refinement technique, a method for the construction of high-quality unstructured spheroidal Delaunay triangulations is introduced. A locally orthogonal polygonal grid, derived from the associated Voronoi diagram, is computed as the staggered dual. It is shown that use of the Frontal-Delaunay refinement technique allows for the generation of very high-quality unstructured triangulations, satisfying a priori bounds on element size and shape. Grid quality is further improved through the application of hill-climbing-type optimisation techniques. Overall, the algorithm is shown to produce grids with very high element quality and smooth grading characteristics, while imposing relatively low computational expense. A selection of uniform and non-uniform spheroidal grids appropriate for high-resolution, multi-scale general circulation modelling are presented. These grids are shown to satisfy the geometric constraints associated with contemporary unstructured C-grid-type finite-volume models, including the Model for Prediction Across Scales (MPAS-O). The use of user-defined mesh-spacing functions to generate smoothly graded, non-uniform grids for multi-resolution-type studies is discussed in detail.

JIGSAW-GEO (1.0): locally orthogonal staggered unstructured grid generation for general circulation modelling on the sphere

NASA Astrophysics Data System (ADS)

Engwirda, Darren

2017-06-01

An algorithm for the generation of non-uniform, locally orthogonal staggered unstructured spheroidal grids is described. This technique is designed to generate very high-quality staggered Voronoi-Delaunay meshes appropriate for general circulation modelling on the sphere, including applications to atmospheric simulation, ocean-modelling and numerical weather prediction. Using a recently developed Frontal-Delaunay refinement technique, a method for the construction of high-quality unstructured spheroidal Delaunay triangulations is introduced. A locally orthogonal polygonal grid, derived from the associated Voronoi diagram, is computed as the staggered dual. It is shown that use of the Frontal-Delaunay refinement technique allows for the generation of very high-quality unstructured triangulations, satisfying a priori bounds on element size and shape. Grid quality is further improved through the application of hill-climbing-type optimisation techniques. Overall, the algorithm is shown to produce grids with very high element quality and smooth grading characteristics, while imposing relatively low computational expense. A selection of uniform and non-uniform spheroidal grids appropriate for high-resolution, multi-scale general circulation modelling are presented. These grids are shown to satisfy the geometric constraints associated with contemporary unstructured C-grid-type finite-volume models, including the Model for Prediction Across Scales (MPAS-O). The use of user-defined mesh-spacing functions to generate smoothly graded, non-uniform grids for multi-resolution-type studies is discussed in detail.

A Numerical Study of Time-Dependent Wind Forcing Off the West Coast of Portugal, 1987 - 1988

DTIC Science & Technology

1991-06-01

Canary Current off the west coast of the Iberian Peninsula . A short review of the general circulation of the atmosphere and ocean in the vicinity of...the Iberian Peninsula is presented here as an aid to understanding the motivation for this investigation. The atmospheric circulation over the Eastern...the west coast of the Iberian Peninsula (Figures 2 and 3). The seasonal 4 variation in the location, intensity and areal coverage of the Azores High

Vortex motion in doubly connected domains

NASA Astrophysics Data System (ADS)

Zannetti, L.; Gallizio, F.; Ottino, G. M.

The unsteady two-dimensional rotational flow past doubly connected domains is analytically addressed. By concentrating the vorticity in point vortices, the flow is modelled as a potential flow with point singularities. The dependence of the complex potential on time is defined according to the Kelvin theorem. The general case of non-null circulations around the solid bodies is discussed. Vortex shedding and time evolution of the circulation past a two-element airfoil and past a two-bladed Darrieus turbine are presented as physically coherent examples.

Atlantic Ocean Circulation at the Last Glacial Maximum: Inferences from Data and Models

DTIC Science & Technology

2012-09-01

available. Uncertainties in proxies themselves, and in the dating of the proxy records, are generally lower for the LGM than for periods further back...proven useful in understanding new aspects of the modern ocean circulation. Due to the poor dating resolution of sediment cores from the LGM period, and...Environmental Processes of the Ice Age: Land, Oceans, Glaciers (EPI- LOG) project was an effort to reconstruct the state of the Earth in glacial states; a

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology.

PubMed

Che, James; Yu, Victor; Dhar, Manjima; Renier, Corinne; Matsumoto, Melissa; Heirich, Kyra; Garon, Edward B; Goldman, Jonathan; Rao, Jianyu; Sledge, George W; Pegram, Mark D; Sheth, Shruti; Jeffrey, Stefanie S; Kulkarni, Rajan P; Sollier, Elodie; Di Carlo, Dino

2016-03-15

Circulating tumor cells (CTCs) are emerging as rare but clinically significant non-invasive cellular biomarkers for cancer patient prognosis, treatment selection, and treatment monitoring. Current CTC isolation approaches, such as immunoaffinity, filtration, or size-based techniques, are often limited by throughput, purity, large output volumes, or inability to obtain viable cells for downstream analysis. For all technologies, traditional immunofluorescent staining alone has been employed to distinguish and confirm the presence of isolated CTCs among contaminating blood cells, although cells isolated by size may express vastly different phenotypes. Consequently, CTC definitions have been non-trivial, researcher-dependent, and evolving. Here we describe a complete set of objective criteria, leveraging well-established cytomorphological features of malignancy, by which we identify large CTCs. We apply the criteria to CTCs enriched from stage IV lung and breast cancer patient blood samples using the High Throughput Vortex Chip (Vortex HT), an improved microfluidic technology for the label-free, size-based enrichment and concentration of rare cells. We achieve improved capture efficiency (up to 83%), high speed of processing (8 mL/min of 10x diluted blood, or 800 μL/min of whole blood), and high purity (avg. background of 28.8±23.6 white blood cells per mL of whole blood). We show markedly improved performance of CTC capture (84% positive test rate) in comparison to previous Vortex designs and the current FDA-approved gold standard CellSearch assay. The results demonstrate the ability to quickly collect viable and pure populations of abnormal large circulating cells unbiased by molecular characteristics, which helps uncover further heterogeneity in these cells.

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology

PubMed Central

Che, James; Yu, Victor; Dhar, Manjima; Renier, Corinne; Matsumoto, Melissa; Heirich, Kyra; Garon, Edward B.; Goldman, Jonathan; Rao, Jianyu; Sledge, George W.; Pegram, Mark D.; Sheth, Shruti; Jeffrey, Stefanie S.; Kulkarni, Rajan P.; Sollier, Elodie; Di Carlo, Dino

2016-01-01

Circulating tumor cells (CTCs) are emerging as rare but clinically significant non-invasive cellular biomarkers for cancer patient prognosis, treatment selection, and treatment monitoring. Current CTC isolation approaches, such as immunoaffinity, filtration, or size-based techniques, are often limited by throughput, purity, large output volumes, or inability to obtain viable cells for downstream analysis. For all technologies, traditional immunofluorescent staining alone has been employed to distinguish and confirm the presence of isolated CTCs among contaminating blood cells, although cells isolated by size may express vastly different phenotypes. Consequently, CTC definitions have been non-trivial, researcher-dependent, and evolving. Here we describe a complete set of objective criteria, leveraging well-established cytomorphological features of malignancy, by which we identify large CTCs. We apply the criteria to CTCs enriched from stage IV lung and breast cancer patient blood samples using the High Throughput Vortex Chip (Vortex HT), an improved microfluidic technology for the label-free, size-based enrichment and concentration of rare cells. We achieve improved capture efficiency (up to 83%), high speed of processing (8 mL/min of 10x diluted blood, or 800 μL/min of whole blood), and high purity (avg. background of 28.8±23.6 white blood cells per mL of whole blood). We show markedly improved performance of CTC capture (84% positive test rate) in comparison to previous Vortex designs and the current FDA-approved gold standard CellSearch assay. The results demonstrate the ability to quickly collect viable and pure populations of abnormal large circulating cells unbiased by molecular characteristics, which helps uncover further heterogeneity in these cells. PMID:26863573

Noninvasive prenatal testing for Wilson disease by use of circulating single-molecule amplification and resequencing technology (cSMART).

PubMed

Lv, Weigang; Wei, Xianda; Guo, Ruolan; Liu, Qin; Zheng, Yu; Chang, Jiazhen; Bai, Ting; Li, Haoxian; Zhang, Jianguang; Song, Zhuo; Cram, David S; Liang, Desheng; Wu, Lingqian

2015-01-01

Noninvasive prenatal testing (NIPT) for monogenic diseases by use of PCR-based strategies requires precise quantification of mutant fetal alleles circulating in the maternal plasma. The study describes the development and validation of a novel assay termed circulating single-molecule amplification and resequencing technology (cSMART) for counting single allelic molecules in plasma. Here we demonstrate the suitability of cSMART for NIPT, with Wilson Disease (WD) as proof of concept. We used Sanger and whole-exome sequencing to identify familial ATP7B (ATPase, Cu(++) transporting, β polypeptide) gene mutations. For cSMART, single molecules were tagged with unique barcodes and circularized, and alleles were targeted and replicated by inverse PCR. The unique single allelic molecules were identified by sequencing and counted, and the percentage of mutant alleles in the original maternal plasma sample was used to determine fetal genotypes. Four families with WD pedigrees consented to the study. Using Sanger and whole-exome sequencing, we mapped the pathogenic ATP7B mutations in each pedigree and confirmed the proband's original diagnosis of WD. After validation of cSMART with defined plasma models mimicking fetal inheritance of paternal, maternal, or both parental mutant alleles, we retrospectively showed in second pregnancies that the fetal genotypes assigned by invasive testing and NIPT were concordant. We developed a reliable and accurate NIPT assay that correctly diagnosed the fetal genotypes in 4 pregnancies at risk for WD. This novel technology has potential as a universal strategy for NIPT of other monogenic disorders, since it requires only knowledge of the parental pathogenic mutations. © 2014 American Association for Clinical Chemistry.

A Coupled Ocean General Circulation, Biogeochemical, and Radiative Model of the Global Oceans: Seasonal Distributions of Ocean Chlorophyll and Nutrients

NASA Technical Reports Server (NTRS)

Gregg, Watson W.; Busalacchi, Antonio (Technical Monitor)

2000-01-01

A coupled ocean general circulation, biogeochemical, and radiative model was constructed to evaluate and understand the nature of seasonal variability of chlorophyll and nutrients in the global oceans. Biogeochemical processes in the model are determined from the influences of circulation and turbulence dynamics, irradiance availability. and the interactions among three functional phytoplankton groups (diatoms. chlorophytes, and picoplankton) and three nutrients (nitrate, ammonium, and silicate). Basin scale (greater than 1000 km) model chlorophyll results are in overall agreement with CZCS pigments in many global regions. Seasonal variability observed in the CZCS is also represented in the model. Synoptic scale (100-1000 km) comparisons of imagery are generally in conformance although occasional departures are apparent. Model nitrate distributions agree with in situ data, including seasonal dynamics, except for the equatorial Atlantic. The overall agreement of the model with satellite and in situ data sources indicates that the model dynamics offer a reasonably realistic simulation of phytoplankton and nutrient dynamics on synoptic scales. This is especially true given that initial conditions are homogenous chlorophyll fields. The success of the model in producing a reasonable representation of chlorophyll and nutrient distributions and seasonal variability in the global oceans is attributed to the application of a generalized, processes-driven approach as opposed to regional parameterization and the existence of multiple phytoplankton groups with different physiological and physical properties. These factors enable the model to simultaneously represent many aspects of the great diversity of physical, biological, chemical, and radiative environments encountered in the global oceans.

Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.

PubMed

Wetmore, Barbara A; Brees, Dominique J; Singh, Reetu; Watkins, Paul B; Andersen, Melvin E; Loy, James; Thomas, Russell S

2010-06-01

Serum aminotransferases have been the clinical standard for evaluating liver injury for the past 50-60 years. These tissue enzymes lack specificity, also tracking injury to other tissues. New technologies assessing tissue-specific messenger RNA (mRNA) release into blood should provide greater specificity and permit indirect assessment of gene expression status of injured tissue. To evaluate the potential of circulating mRNAs as biomarkers of liver injury, rats were treated either with hepatotoxic doses of D-(+)-galactosamine (DGAL) or acetaminophen (APAP) or a myotoxic dose of bupivacaine HCl (BPVC). Plasma, serum, and liver samples were obtained from each rat. Serum alanine aminotransferase and aspartate aminotransferase were increased by all three compounds, whereas circulating liver-specific mRNAs were only increased by the hepatotoxicants. With APAP, liver-specific mRNAs were significantly increased in plasma at doses that had no effect on serum aminotransferases or liver histopathology. Characterization of the circulating mRNAs by sucrose density gradient centrifugation revealed that the liver-specific mRNAs were associated with both necrotic debris and microvesicles. DGAL treatment also induced a shift in the size of plasma microvesicles, consistent with active release of microvesicles following liver injury. Finally, gene expression microarray analysis of the plasma following DGAL and APAP treatment revealed chemical-specific profiles. The comparative analysis of circulating liver mRNAs with traditional serum transaminases and histopathology indicated that the circulating liver mRNAs were more specific and more sensitive biomarkers of liver injury. Further, the possibility of identifying chemical-specific transcriptional profiles from circulating mRNAs could open a range of possibilities for identifying the etiology of drug/chemical-induced liver injury.

Complex use of waste in wastewater and circulating water treatment from oil in heat power stations

NASA Astrophysics Data System (ADS)

Nikolaeva, L. A.; Iskhakova, R. Ya.

2017-06-01

Sewage and circulating water from oil of thermal power plants (TPP) generated in fuel-oil shops during washing of electrical equipment and its running into the storm drainage system from the industrial site has been considered in the paper. It has been suggested to use the carbonate sludge of water treatment modified with hydrophobing emulsion as a sorption material for waste and circulating water treatment in thermal power plants. The carbonate sludge is waste accumulated in clarifiers at the stage of natural water pretreatment. General technical characteristics of the sludge, such as moisture, bulk density, total pore volume, ash, etc., have been determined. It has been found that the sludge without additional treatment is a hydrophilic material that has low adsorption capacity and wettability with nonpolar compounds. Therefore, the sludge is treated with organosilicon compounds to reduce the moisture capacity and increase its floatation. Several types of sorption materials based on the carbonate sludge subjected to surface and volume hydrophobization have been developed. During the volume treatment, the hydrophobing compound has been introduced into the material along with the plastifier. In case of the surface treatment, heat-treated granules have been soaked into hydrophobing emulsion. It has been shown that surface hydrophobization is most economically advantageous, because it reduces the consumption of water-repelling agent, wherein the total pore volume and sorption capacity during surface hydrophobization increase by 45 and 25% compared to that during volume hydrophobization. Based on the obtained results, the most effective sorption material has been chosen. To produce this material, it is necessary to sequentially carry out mixing of carbonate sludge with the binder, granulation, calcination, impregnation with a waterrepellent emulsion, and drying of the finished material. The suggested technology to produce the material and use it as a sorbent allows efficient wastewater treatment from oil as well as reduction of anthropogenic pressure on the environment and economic costs of the station for nature protection measures.

On the limitations of General Circulation Climate Models

NASA Technical Reports Server (NTRS)

Stone, Peter H.; Risbey, James S.

1990-01-01

General Circulation Models (GCMs) by definition calculate large-scale dynamical and thermodynamical processes and their associated feedbacks from first principles. This aspect of GCMs is widely believed to give them an advantage in simulating global scale climate changes as compared to simpler models which do not calculate the large-scale processes from first principles. However, it is pointed out that the meridional transports of heat simulated GCMs used in climate change experiments differ from observational analyses and from other GCMs by as much as a factor of two. It is also demonstrated that GCM simulations of the large scale transports of heat are sensitive to the (uncertain) subgrid scale parameterizations. This leads to the question whether current GCMs are in fact superior to simpler models for simulating temperature changes associated with global scale climate change.

Scale dependence of the 200-mb divergence inferred from EOLE data.

NASA Technical Reports Server (NTRS)

Morel, P.; Necco, G.

1973-01-01

The EOLE experiment with 480 constant-volume balloons distributed over the Southern Hemisphere approximately at the 200-mb level, has provided a unique, highly accurate set of tracer trajectories in the general westerly circulation. The trajectories of neighboring balloons are analyzed to estimate the horizontal divergence from the Lagrangian derivative of the area of one cluster. The variance of the divergence estimates results from two almost comparable effects: the true divergence of the horizontal flow and eddy diffusion due to small-scale, two-dimensional turbulence. Taking this into account, the rms divergence is found to be of the order of 0.00001 per sec and decreases logarithmically with cluster size. This scale dependence is shown to be consistent with the quasi-geostrophic turbulence model of the general circulation in midlatitudes.

Simulation of the planetary boundary layer with the UCLA general circulation model

NASA Technical Reports Server (NTRS)

Suarez, M. J.; Arakawa, A.; Randall, D. A.

1981-01-01

A planetary boundary layer (PBL) model is presented which employs a mixed layer entrainment formulation to describe the mass exchange between the mixed layer with the upper, laminar atmosphere. A modified coordinate system couples the mixed layer model with large scale and sub-grid scale processes of a general circulation model. The vertical coordinate is configured as a sigma coordinate with the lower boundary, the top of the PBL, and the prescribed pressure level near the tropopause expressed as coordinate surfaces. The entrainment mass flux is parameterized by assuming the dissipation rate of turbulent kinetic energy to be proportional to the positive part of the generation by convection or mechanical production. The results of a simulation of July are presented for the entire globe.

Projecting Range Limits with Coupled Thermal Tolerance - Climate Change Models: An Example Based on Gray Snapper (Lutjanus griseus) along the U.S. East Coast

PubMed Central

Hare, Jonathan A.; Wuenschel, Mark J.; Kimball, Matthew E.

2012-01-01

We couple a species range limit hypothesis with the output of an ensemble of general circulation models to project the poleward range limit of gray snapper. Using laboratory-derived thermal limits and statistical downscaling from IPCC AR4 general circulation models, we project that gray snapper will shift northwards; the magnitude of this shift is dependent on the magnitude of climate change. We also evaluate the uncertainty in our projection and find that statistical uncertainty associated with the experimentally-derived thermal limits is the largest contributor (∼ 65%) to overall quantified uncertainty. This finding argues for more experimental work aimed at understanding and parameterizing the effects of climate change and variability on marine species. PMID:23284974

Tracer water transport and subgrid precipitation variation within atmospheric general circulation models

NASA Astrophysics Data System (ADS)

Koster, Randal D.; Eagleson, Peter S.; Broecker, Wallace S.

1988-03-01

A capability is developed for monitoring tracer water movement in the three-dimensional Goddard Institute for Space Science Atmospheric General Circulation Model (GCM). A typical experiment with the tracer water model follows water evaporating from selected grid squares and determines where this water first returns to the Earth's surface as precipitation or condensate, thereby providing information on the lateral scales of hydrological transport in the GCM. Through a comparison of model results with observations in nature, inferences can be drawn concerning real world water transport. Tests of the tracer water model include a comparison of simulated and observed vertically-integrated vapor flux fields and simulations of atomic tritium transport from the stratosphere to the oceans. The inter-annual variability of the tracer water model results is also examined.

The influence of orographic waves and quasi-biennial oscillations on vertical ozone flux in the model of general atmospheric circulation

NASA Astrophysics Data System (ADS)

Gavrilov, Nikolai M.; Koval, Andrey V.; Pogoreltsev, Alexander I.; Savenkova, Elena N.

2017-11-01

A parameterization of the dynamical and thermal effects of orographic gravity waves (OGWs) and assimilation quasibiennial oscillations (QBOs) of the zonal wind in the equatorial lower atmosphere are implemented into the numerical model of the general circulation of the middle and upper atmosphere MUAM. The sensitivity of vertical ozone fluxes to the effects of stationary OGWs at different QBO phases at altitudes up to 100 km for January is investigated. The simulated changes in vertical velocities produce respective changes in vertical ozone fluxes caused by the effects of the OGW parameterization and the transition from the easterly to the westerly QBO phase. These changes can reach 40 - 60% in the Northern Hemisphere at altitudes of the middle atmosphere.

Atmospheric planetary wave response to external forcing

NASA Technical Reports Server (NTRS)

Stevens, D. E.; Reiter, E. R.

1985-01-01

The tools of observational analysis, complex general circulation modeling, and simpler modeling approaches were combined in order to attack problems on the largest spatial scales of the earth's atmosphere. Two different models were developed and applied. The first is a two level, global spectral model which was designed primarily to test the effects of north-south sea surface temperature anomaly (SSTA) gradients between the equatorial and midlatitude north Pacific. The model is nonlinear, contains both radiation and a moisture budget with associated precipitation and surface evaporation, and utilizes a linear balance dynamical framework. Supporting observational analysis of atmospheric planetary waves is briefly summarized. More extensive general circulation models have also been used to consider the problem of the atmosphere's response, especially in the horizontal propagation of planetary scale waves, to SSTA.

Tracer water transport and subgrid precipitation variation within atmospheric general circulation models

NASA Technical Reports Server (NTRS)

Koster, Randal D.; Eagleson, Peter S.; Broecker, Wallace S.

1988-01-01

A capability is developed for monitoring tracer water movement in the three-dimensional Goddard Institute for Space Science Atmospheric General Circulation Model (GCM). A typical experiment with the tracer water model follows water evaporating from selected grid squares and determines where this water first returns to the Earth's surface as precipitation or condensate, thereby providing information on the lateral scales of hydrological transport in the GCM. Through a comparison of model results with observations in nature, inferences can be drawn concerning real world water transport. Tests of the tracer water model include a comparison of simulated and observed vertically-integrated vapor flux fields and simulations of atomic tritium transport from the stratosphere to the oceans. The inter-annual variability of the tracer water model results is also examined.

The Shattered Stereotype: The Academic Library in Technological Transition.

ERIC Educational Resources Information Center

Foster, Constance L.

In academic libraries, neither technical services, public services, nor administration has escaped the impact of online information systems. Online catalogs, network systems, interlibrary lending, database searches, circulation control, automated technical processes, and an increasing number of non-book materials are part of a technological…

Evaluating School Library Information Services in the Digital Age.

ERIC Educational Resources Information Center

Everhart, Nancy

2000-01-01

Discusses criteria for evaluating school library information services. Highlights include types of services; physical facilities; library usage; circulation statistics; changes due to technology; fill rate, or the percentage of successful searches for library materials; OPAC (online public access catalog) reports; observation; and examining…

A microfluidic device for label-free, physical capture of circulating tumor cell-clusters

PubMed Central

Sarioglu, A. Fatih; Aceto, Nicola; Kojic, Nikola; Donaldson, Maria C.; Zeinali, Mahnaz; Hamza, Bashar; Engstrom, Amanda; Zhu, Huili; Sundaresan, Tilak K.; Miyamoto, David T.; Luo, Xi; Bardia, Aditya; Wittner, Ben S.; Ramaswamy, Sridhar; Shioda, Toshi; Ting, David T.; Stott, Shannon L.; Kapur, Ravi; Maheswaran, Shyamala; Haber, Daniel A.; Toner, Mehmet

2015-01-01

Cancer cells metastasize through the bloodstream either as single migratory circulating tumor cells (CTCs) or as multicellular groupings (CTC-clusters). Existing technologies for CTC enrichment are designed primarily to isolate single CTCs, and while CTC-clusters are detectable in some cases, their true prevalence and significance remain to be determined. Here, we developed a microchip technology (Cluster-Chip) specifically designed to capture CTC-clusters independent of tumor-specific markers from unprocessed blood. CTC-clusters are isolated through specialized bifurcating traps under low shear-stress conditions that preserve their integrity and even two-cell clusters are captured efficiently. Using the Cluster-Chip, we identify CTC-clusters in 30–40% of patients with metastatic cancers of the breast, prostate and melanoma. RNA sequencing of CTC-clusters confirms their tumor origin and identifies leukocytes within the clusters as tissue-derived macrophages. Together, the development of a device for efficient capture of CTC-clusters will enable detailed characterization of their biological properties and role in cancer metastasis. PMID:25984697

Microfluidic devices to enrich and isolate circulating tumor cells

PubMed Central

Myung, J. H.; Hong, S.

2015-01-01

Given the potential clinical impact of circulating tumor cells (CTCs) in blood as a clinical biomarker for diagnosis and prognosis of various cancers, a myriad of detection methods for CTCs have been recently introduced. Among those, a series of microfluidic devices are particularly promising as these uniquely offer micro-scale analytical systems that are highlighted by low consumption of samples and reagents, high flexibility to accommodate other cutting-edge technologies, precise and well-defined flow behaviors, and automation capability, presenting significant advantages over the conventional larger scale systems. In this review, we highlight the advantages of microfluidic devices and their translational potential into CTC detection methods, categorized by miniaturization of bench-top analytical instruments, integration capability with nanotechnologies, and in situ or sequential analysis of captured CTCs. This review provides a comprehensive overview of recent advances in the CTC detection achieved through application of microfluidic devices and their challenges that these promising technologies must overcome to be clinically impactful. PMID:26549749

Development and Analysis of Cold Trap for Use in Fission Surface Power-Primary Test Circuit

NASA Technical Reports Server (NTRS)

Wolfe, T. M.; Dervan, C. A.; Pearson, J. B.; Godfroy, T. J.

2012-01-01

The design and analysis of a cold trap proposed for use in the purification of circulated eutectic sodium potassium (NaK-78) loops is presented. The cold trap is designed to be incorporated into the Fission Surface Power-Primary Test Circuit (FSP-PTC), which incorporates a pumped NaK loop to simulate in-space nuclear reactor-based technology using non-nuclear test methodology as developed by the Early Flight Fission-Test Facility. The FSP-PTC provides a test circuit for the development of fission surface power technology. This system operates at temperatures that would be similar to those found in a reactor (500-800 K). By dropping the operating temperature of a specified percentage of NaK flow through a bypass containing a forced circulation cold trap, the NaK purity level can be increased by precipitating oxides from the NaK and capturing them within the cold trap. This would prevent recirculation of these oxides back through the system, which may help prevent corrosion.

Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips†

PubMed Central

Earhart, Christopher M.; Hughes, Casey E.; Gaster, Richard S.; Ooi, Chin Chun; Wilson, Robert J.; Zhou, Lisa Y.; Humke, Eric W.; Xu, Lingyun; Wong, Dawson J.; Willingham, Stephen B.; Schwartz, Erich J.; Weissman, Irving L.; Jeffrey, Stefanie S.; Neal, Joel W.; Rohatgi, Rajat; Wakelee, Heather A.; Wang, Shan X.

2014-01-01

Detection and characterization of circulating tumor cells (CTCs) may reveal insights into the diagnosis and treatment of malignant disease. Technologies for isolating CTCs developed thus far suffer from one or more limitations, such as low throughput, inability to release captured cells, and reliance on expensive instrumentation for enrichment or subsequent characterization. We report a continuing development of a magnetic separation device, the magnetic sifter, which is a miniature microfluidic chip with a dense array of magnetic pores. It offers high efficiency capture of tumor cells, labeled with magnetic nanoparticles, from whole blood with high throughput and efficient release of captured cells. For subsequent characterization of CTCs, an assay, using a protein chip with giant magnetoresistive nanosensors, has been implemented for mutational analysis of CTCs enriched with the magnetic sifter. The use of these magnetic technologies, which are separate devices, may lead the way to routine preparation and characterization of “liquid biopsies” from cancer patients. PMID:23969419

Honors

NASA Astrophysics Data System (ADS)

2012-10-01

Many AGU members are among the American Meteorological Society's (AMS) 2013 honorary members, awardees, lecturers, and fellows. Among the AMS honorary members is Susan Solomon, the Ellen Swallow Richards Professor of Atmospheric Chemistry and Climate Science at the Massachusetts Institute of Technology (MIT). Dennis Hartmann, of the University of Washington, Seattle, is the recipient of AMS's Carl-Gustaf Rossby Research Medal “for significant contributions to the synthesis of knowledge of radiative and dynamical processes leading to a deeper understanding of the climate system.” R. Alan Plumb, professor of meteorology at MIT, receives the Jule G. Charney Award “for fundamental contributions to the understanding of geophysical fluid dynamics, stratospheric dynamics, chemical transport, and the general circulation of the atmosphere and oceans.” The Verner E. Suomi Award has been given to Richard Johnson, professor of atmospheric science at Colorado State University, Fort Collins, “for exquisite design of rawinsonde networks in field campaigns and insightful analysis of interactions between convective clouds and the largescale atmospheric circulation.” W. Kendall Melville, professor of oceanography at the Scripps Institution of Oceanography, University of California, San Diego, has been awarded the Sverdrup Gold Medal Award “for pioneering contributions in advancing knowledge on the role of surface wave breaking and related processes in air-sea interaction.” AMS announced that Laurence Armi, also a professor of oceanography at Scripps, is recipient of the Henry Stommel Research Award “for his deeply insightful studies of stratified flow, his pioneering work on boundary mixing and other turbulent mechanisms.”

HOX Genes as Potential Markers of Circulating Tumour Cells.

PubMed

Morgan, R; El-Tanani, M

2016-01-01

Circulating tumour cells (CTCs) have significant diagnostic potential as they can reflect both the presence and recurrence of a wide range of cancers. However, this potential continues to be limited by the lack of robust and accessible isolation technologies. An alternative to isolation might be their direct detection amongst other peripheral blood cells, although this would require markers that allow them to be distinguished from an exceptionally high background signal. This review assesses the potential role of HOX genes, a family of homeodomain containing transcription factors with key roles in both embryonic development and oncogenesis, as unique and possibly disease specific markers of CTCs.

Circulating Cell-Free Tumour DNA in the Management of Cancer

PubMed Central

Francis, Glenn; Stein, Sandra

2015-01-01

With the development of new sensitive molecular techniques, circulating cell-free tumour DNA containing mutations can be identified in the plasma of cancer patients. The applications of this technology may result in significant changes to the care and management of cancer patients. Whilst, currently, these “liquid biopsies” are used to supplement the histological diagnosis of cancer and metastatic disease, in the future these assays may replace the need for invasive procedures. Applications include the monitoring of tumour burden, the monitoring of minimal residual disease, monitoring of tumour heterogeneity, monitoring of molecular resistance and early diagnosis of tumours and metastatic disease. PMID:26101870

Moisture and wave-mean flow interactions in the general circulation of Earth's atmosphere

NASA Astrophysics Data System (ADS)

Yamada, Ray

Baroclinic eddies play an important role in shaping the midlatitude climate and its variability. They are the dominant means by which heat, momentum, and water vapor are transported in the atmosphere, but their turbulent nature makes it challenging to grasp their aggregate effect on the mean circulation. Wave-mean flow diagnostics provide an effective means for understanding the interactions between eddies and the mean circulation. These diagnostics are derived by dynamically motivated averaging of the equations of motion, which exposes the total explicit eddy effect on the mean circulation tendency. Most of the classic formulations of these diagnostics have been limited by the fact that they do not account for the eddy flux of water vapor, which can drive circulation through latent heat released from condensation. In the first part of this thesis, a moist isentropic generalization of the Eliassen-Palm (EP) flux diagnostic is developed. Moist isentropes are often not invertible with height, which prevents the standard techniques used to derive the dry diagnostic from being applied in the moist case. This issue is resolved by using a conditional-averaging approach to define a weak coordinate transformation. The primitive equations, EP flux, and EP theorem are derived in generality for non- invertible coordinates, without assumptions of quasi-geostrophy or small wave-amplitude. It is shown that, in the reanalysis climatology, the moist EP flux is twice as strong as the dry EP flux and has a greater equatorward extent. Physically, the increase in momentum exchange is tied to an enhancement of the form drag associated with the horizontal structure of midlatitude eddies, where the poleward flow of moist air is located in regions of strong eastward pressure gradients. The second part of this thesis studies the effect of latent heating on the mean flow adjustment in idealized baroclinic life cycles. The life cycles are simulated in an idealized moist general circulation model (GCM) with no convective parameterizations and diabatic heating is due entirely to the latent heat released from large-scale condensation. A series of life cycle simulations are run varying only the initially prescribed value of the relative humidity. It is shown that increasing relative humidity acts to decrease the baroclinic shear of the adjusting zonal jet. By solving a moist elliptic equation for the Eulerian-mean circulation forced by the eddy fluxes, it is shown that the eddy moisture flux drives an indirect Eulerian circulation on the equatorward flank of the jet. This in turn increases the strength and equatorward extent of the developing surface westerlies. The reduction of baroclinicity is consistent with the earlier idea that moisture fluxes increase the EP flux and form drag associated with baroclinic eddies. The final topic of this thesis is about the extratropical internal variability of the atmosphere. The annular mode (AM) has long been considered the dominant mode of atmospheric variability driven by midlatitude storms. It describes a north-south vacillation of the eddy-driven jet on intraseasonal timescales which are considerably longer than the life cycle of typical synoptic storms. This low-frequency variability of the AM is thought to be supported by a mean-eddy feedback, in which a poleward shift of the jet is supported by a poleward shift of the baroclinic zone. However, it is shown that the atmospheric energy transport and isentropic circulation shift equatorward in the monthly AM composites. This shift is mainly the result of a poleward shift of the Ferrel cell. An alternative mean-eddy feedback mechanism based on the idea of the jet acting as a mixing barrier is proposed as an explanation for the small response of the eddy energy flux.

Large Scale Eocene Ocean Circulation Transition Could Help Antarctic Glaciation.

NASA Astrophysics Data System (ADS)

Baatsen, M.

2016-12-01

The global climate underwent major changes going from the Eocene into the Oligocene, including the formation of a continental-scale Antarctic ice sheet. In addition to a gradual drawdown of CO2 since the Early Eocene, the changing background geography of the earth may also have played a crucial role in setting the background oceanic circulation pattern favorable to ice growth. On the other hand, the ocean circulation may have changed only after the ice sheet started growing, with a similar climatic imprint. It is, therefore, still under debate what the primary forcing or trigger of this transition was. Using an ocean general circulation model (POP) and two different geography reconstruc-tions for the middle-late Eocene, we find two distinctly different patterns of the oceanic circulation to be possible under the same forcing. The first one features deep-water formation and warmer SSTs in the Southern Pacific while in the second, deep water forms in the North Pacific Ocean and Southern Ocean SSTs are colder. The presence of a double equilibrium shows that the ocean circulation was highly susceptible to large scale transitions during the middle-late Eocene. Additionally, changes in benthic oxygen and Neodymium isotopes depict significant changes during the same period. We suggest that a transition in the global meridional overturing circulation can explain the observed changes and preconditions the global climate for the two-step transition into an Icehouse state at the Eocene-Oligocene boundary.

Recent changes in the summer monsoon circulation and their impact on dynamics and thermodynamics of the Arabian Sea

NASA Astrophysics Data System (ADS)

Pratik, Kad; Parekh, Anant; Karmakar, Ananya; Chowdary, Jasti S.; Gnanaseelan, C.

2018-05-01

The present study examines changes in the low-level summer monsoon circulation over the Arabian Sea and their impact on the ocean dynamics using reanalysis data. The study confirms intensification and northward migration of low-level jet during 1979 to 2015. Further during the study period, an increase in the Arabian Sea upper ocean heat content is found in spite of a decreasing trend in the net surface heat flux, indicating the possible role of ocean dynamics in the upper ocean warming. Increase in the anti-cyclonic wind stress curl associated with the change in the monsoon circulation induces downwelling over the central Arabian Sea, favoring upper ocean warming. The decreasing trend of southward Ekman transport, a mechanism transporting heat from the land-locked north Indian Ocean to southern latitudes, also supports increasing trend of the upper ocean heat content. To reinstate and quantify the role of changing monsoon circulation in increasing the heat content over the Arabian Sea, sensitivity experiment is carried out using ocean general circulation model. In this experiment, the model is forced by inter-annual momentum forcing while rest of the forcing is climatological. Experiment reveals that the changing monsoon circulation increases the upper ocean heat content, effectively by enhancing downwelling processes and reducing southward heat transport, which strongly endorses our hypothesis that changing ocean dynamics associated with low-level monsoon circulation is causing the increasing trend in the heat content of the Arabian Sea.

Biomass Burning

Atmospheric Science Data Center

2015-07-27

Projects:  Biomass Burning Definition/Description:  Biomass Burning: This data set represents the geographical and temporal distribution of total amount of biomass burned. These data may be used in general circulation models (GCMs) and ...

Climate model biases in jet streams, blocking and storm tracks resulting from missing orographic drag

NASA Astrophysics Data System (ADS)

Pithan, Felix; Shepherd, Theodore G.; Zappa, Giuseppe; Sandu, Irina

2016-07-01

State-of-the art climate models generally struggle to represent important features of the large-scale circulation. Common model deficiencies include an equatorward bias in the location of the midlatitude westerlies and an overly zonal orientation of the North Atlantic storm track. Orography is known to strongly affect the atmospheric circulation and is notoriously difficult to represent in coarse-resolution climate models. Yet how the representation of orography affects circulation biases in current climate models is not understood. Here we show that the effects of switching off the parameterization of drag from low-level orographic blocking in one climate model resemble the biases of the Coupled Model Intercomparison Project Phase 5 ensemble: An overly zonal wintertime North Atlantic storm track and less European blocking events, and an equatorward shift in the Southern Hemispheric jet and increase in the Southern Annular Mode time scale. This suggests that typical circulation biases in coarse-resolution climate models may be alleviated by improved parameterizations of low-level drag.

Global warming hiatus contributed to the increased occurrence of intense tropical cyclones in the coastal regions along East Asia.

PubMed

Zhao, Jiuwei; Zhan, Ruifen; Wang, Yuqing

2018-04-16

The recent global warming hiatus (GWH) was characterized by a La Niña-like cooling in the tropical Eastern Pacific accompanied with the Indian Ocean and the tropical Atlantic Ocean warming. Here we show that the recent GWH contributed significantly to the increased occurrence of intense tropical cyclones in the coastal regions along East Asia since 1998. The GWH associated sea surface temperature anomalies triggered a pair of anomalous cyclonic and anticyclonic circulations and equatorial easterly anomalies over the Northwest Pacific, which favored TC genesis and intensification over the western Northwest Pacific but suppressed TC genesis and intensification over the southeastern Northwest Pacific due to increased vertical wind shear and anticyclonic circulation anomalies. Results from atmospheric general circulation model experiments demonstrate that the Pacific La Niña-like cooling dominated the Indian Ocean and the tropical Atlantic Ocean warming in contributing to the observed GWH-related anomalous atmospheric circulation over the Northwest Pacific.

Understanding the Asian summer monsoon response to greenhouse warming: the relative roles of direct radiative forcing and sea surface temperature change

NASA Astrophysics Data System (ADS)

Li, Xiaoqiong; Ting, Mingfang

2017-10-01

Future hydroclimate projections from state-of-the-art climate models show large uncertainty and model spread, particularly in the tropics and over the monsoon regions. The precipitation and circulation responses to rising greenhouse gases involve a fast component associated with direct radiative forcing and a slow component associated with sea surface temperature (SST) warming; the relative importance of the two may contribute to model discrepancies. In this study, regional hydroclimate responses to greenhouse warming are assessed using output from coupled general circulation models in the Coupled Model Intercomparison Project-Phase 5 (CMIP5) and idealized atmospheric general circulation model experiments from the Atmosphere Model Intercomparison Project. The thermodynamic and dynamic mechanisms causing the rainfall changes are examined using moisture budget analysis. Results show that direct radiative forcing and SST change exert significantly different responses both over land and ocean. For most part of the Asian monsoon region, the summertime rainfall changes are dominated by the direct CO2 radiative effect through enhanced monsoon circulation. The response to SST warming shows a larger model spread compared to direct radiative forcing, possibly due to the cancellation between the thermodynamical and dynamical components. While the thermodynamical response of the Asian monsoon is robust across the models, there is a lack of consensus for the dynamical response among the models and weak multi-model mean responses in the CMIP5 ensemble, which may be related to the multiple physical processes evolving on different time scales.

Seasonal surface circulation, temperature, and salinity in Prince William Sound, Alaska

NASA Astrophysics Data System (ADS)

Musgrave, David L.; Halverson, Mark J.; Scott Pegau, W.

2013-02-01

Salinity, temperature, and depth profiles from 1973 to 2010 were used to construct a seasonal climatology of surface temperature, surface salinity, mixed layer depth (MLD), potential energy of mixing, and surface geostrophic circulation in Prince William Sound (PWS) and the adjacent Gulf of Alaska. Surface salinity is greatest in winter and least in summer due to the influence of increased freshwater runoff in summer. It is generally lowest in the northwest and highest in the Gulf of Alaska. The surface temperature is lowest in the winter and highest in the summer when surface heating is greatest, with little spatial variability across the Sound. The MLD is deepest in winter (9-27 m) and shallowest in summer (4-5 m). The work by winds was estimated from meteorological buoy data in central PWS and compared to the potential energy of mixing of the upper water column. The potential depth to which winds mix the upper water column was generally consistent with the MLD. The surface geostrophic circulation in the central Sound has: a southerly flow in the western central Sound in the winter; a closed, weak anticyclonic cell in spring; a closed, cyclonic cell in the summer; an open, cyclonic circulation in the fall. In the western passages, a southerly flow occurs in spring, summer, and fall. These results have important implications for oil spill response in PWS, the use of oil dispersants, and for comparison to numerical studies.

Comparisons of observed seasonal climate features with a winter and summer numerical simulation produced with the GLAS general circulation model

NASA Technical Reports Server (NTRS)

Halem, M.; Shukla, J.; Mintz, Y.; Wu, M. L.; Godbole, R.; Herman, G.; Sud, Y.

1979-01-01

Results are presented from numerical simulations performed with the general circulation model (GCM) for winter and summer. The monthly mean simulated fields for each integration are compared with observed geographical distributions and zonal averages. In general, the simulated sea level pressure and upper level geopotential height field agree well with the observations. Well simulated features are the winter Aleutian and Icelandic lows, the summer southwestern U.S. low, the summer and winter oceanic subtropical highs in both hemispheres, and the summer upper level Tibetan high and Atlantic ridge. The surface and upper air wind fields in the low latitudes are in good agreement with the observations. The geographical distirbutions of the Earth-atmosphere radiation balance and of the precipitation rates over the oceans are well simulated, but not all of the intensities of these features are correct. Other comparisons are shown for precipitation along the ITCZ, rediation balance, zonally averaged temperatures and zonal winds, and poleward transports of momentum and sensible heat.

Estimates of runoff using water-balance and atmospheric general circulation models

USGS Publications Warehouse

Wolock, D.M.; McCabe, G.J.

1999-01-01

The effects of potential climate change on mean annual runoff in the conterminous United States (U.S.) are examined using a simple water-balance model and output from two atmospheric general circulation models (GCMs). The two GCMs are from the Canadian Centre for Climate Prediction and Analysis (CCC) and the Hadley Centre for Climate Prediction and Research (HAD). In general, the CCC GCM climate results in decreases in runoff for the conterminous U.S., and the HAD GCM climate produces increases in runoff. These estimated changes in runoff primarily are the result of estimated changes in precipitation. The changes in mean annual runoff, however, mostly are smaller than the decade-to-decade variability in GCM-based mean annual runoff and errors in GCM-based runoff. The differences in simulated runoff between the two GCMs, together with decade-to-decade variability and errors in GCM-based runoff, cause the estimates of changes in runoff to be uncertain and unreliable.

Role of circulation in European heatwaves using flow analogues

NASA Astrophysics Data System (ADS)

Jézéquel, Aglaé; Yiou, Pascal; Radanovics, Sabine

2018-02-01

The intensity of European heatwaves is connected to specific synoptic atmospheric circulation. Given the relatively small number of observations, estimates of the connection between the circulation and temperature require ad hoc statistical methods. This can be achieved through the use of analogue methods, which allow to determine a distribution of temperature conditioned to the circulation. The computation of analogues depends on a few parameters. In this article, we evaluate the influence of the variable representing the circulation, the size of the domain of computation, the length of the dataset, and the number of analogues on the reconstituted temperature anomalies. We tested the sensitivity of the reconstitution of temperature to these parameters for four emblematic recent heatwaves: June 2003, August 2003, July 2006 and July 2015. The paper provides general guidelines for the use of flow analogues to investigate European summer heatwaves. We found that Z500 is better suited than SLP to simulate temperature anomalies, and that rather small domains lead to better reconstitutions. The dataset length has an important influence on the uncertainty. We conclude by a set of recommendations for an optimal use of analogues to probe European heatwaves.

Efficiency of circulant diallels via mixed models in the selection of papaya genotypes resistant to foliar fungal diseases.

PubMed

Vivas, M; Silveira, S F; Viana, A P; Amaral, A T; Cardoso, D L; Pereira, M G

2014-07-02

Diallel crossing methods provide information regarding the performance of genitors between themselves and their hybrid combinations. However, with a large number of parents, the number of hybrid combinations that can be obtained and evaluated become limited. One option regarding the number of parents involved is the adoption of circulant diallels. However, information is lacking regarding diallel analysis using mixed models. This study aimed to evaluate the efficacy of the method of linear mixed models to estimate, for variable resistance to foliar fungal diseases, components of general and specific combining ability in a circulant table with different s values. Subsequently, 50 diallels were simulated for each s value, and the correlations and estimates of the combining abilities of the different diallel combinations were analyzed. The circulant diallel method using mixed modeling was effective in the classification of genitors regarding their combining abilities relative to the complete diallels. The numbers of crosses in which each genitor(s) will compose the circulant diallel and the estimated heritability affect the combining ability estimates. With three crosses per parent, it is possible to obtain good concordance (correlation above 0.8) between the combining ability estimates.

47 CFR 76.122 - Satellite network non-duplication.

Code of Federal Regulations, 2012 CFR

2012-10-01

... carrier may rely on information from newspapers or magazines of general circulation, the broadcaster... distributed superstation shall answer the request: (i) Within ten business days following its receipt of the...

47 CFR 76.122 - Satellite network non-duplication.

Code of Federal Regulations, 2014 CFR

2014-10-01

... carrier may rely on information from newspapers or magazines of general circulation, the broadcaster... distributed superstation shall answer the request: (i) Within ten business days following its receipt of the...

47 CFR 76.122 - Satellite network non-duplication.

Code of Federal Regulations, 2013 CFR

2013-10-01

... carrier may rely on information from newspapers or magazines of general circulation, the broadcaster... distributed superstation shall answer the request: (i) Within ten business days following its receipt of the...

Bibliographic Utilities and the Use of Microcomputers in Libraries: Current and Projected Practices.

ERIC Educational Resources Information Center

McAninch, Glen

1986-01-01

Bibliographic utilities are marketing specially designed hardware and software that permit libraries to patch together automated cataloging, acquisitions, serials control, reference, online public catalogs, circulation, interlibrary loan, and administrative functions. The increasing complexity of the technology is making it more difficult to…

Medical Complications of the Critically Ill Newborn: A Review for Early Intervention Professionals.

ERIC Educational Resources Information Center

McNab, Theresa C.; Blackman, James A.

1998-01-01

Provides early-intervention professionals with a basic familiarity and understanding of some of the newest technologies employed in the neonatal intensive care units for neonates with respiratory distress syndrome, persistent fetal circulation, retinopathy of prematurity, intraventricular hemorrhage, and periventricular leukomalacia. Early…

Intercomparison of General Circulation Models for Hot Extrasolar Planet Atmospheres

NASA Astrophysics Data System (ADS)

Cho, James

2013-11-01

In this collaborative work with I. Polichtchouk, C. Watkins, H. Th. Thrastarson, O. M. Umurhan, and M. de la Torre-Juárez, we compare five general circulation models (GCMs) which have been recently used to study hot extrasolar planet atmospheres (BOB, CAM, IGCM, MITgcm, and PEQMOD), under three test cases useful for assessing model convergence and accuracy. Such a broad, detailed intercomparison has not been performed thus far for extrasolar planets study. The models considered all solve the traditional primitive equations, but employ different numerical algorithms or grids (e.g., pseudospectral and finite volume, with the latter separately in longitude-latitude and ``cubed-sphere'' grids). The test cases are chosen to cleanly address specific aspects of the behaviors typically reported in hot extrasolar planet simulations: 1) steady-state, 2) nonlinearly evolving baroclinic wave, and 3) response to fast timescale thermal relaxation. When initialized with a steady jet, all models maintain the steadiness, as they should--except MITgcm in cubed-sphere grid. A very good agreement is obtained for a baroclinic wave evolving from an initial instability in spectral models (only). However, exact numerical convergence is still not achieved across the spectral models: amplitudes and phases are observably different. When subject to a typical ``hot-Jupiter''-like forcing, all five models show quantitatively different behavior--although qualitatively similar, time-variable, quadrupole-dominated flows are produced. Hence, as have been advocated in several past studies, specific quantitative predictions (such as the location of large vortices and hot regions) by GCMs should be viewed with caution. Overall, in the tests considered here, spectral models in pressure coordinate (PEBOB and PEQMOD) perform the best and MITgcm in cubed-sphere grid performs the worst. This work has been supported by the Science and Technology Facilities Council, Westfield Small Grant, NASA Postdoctoral Program, and Institute for Theory and Computation, Harvard College Observatory.

Evolution of ocean-induced ice melt beneath Zachariæ Isstrøm, Northeast Greenland combining observations and an ocean general circulation model from 1978 to present

NASA Astrophysics Data System (ADS)

Cai, C.; Rignot, E. J.; Menemenlis, D.; Millan, R.; Bjørk, A. A.; Khan, S. A.; Charolais, A.

2017-12-01

Zachariæ Isstrøm, a major ice stream in northeast Greenland, lost a large fraction of its ice shelf during the last decade. We study the evolution of subaqueous melting of its floating section from 1978 to present. The ice shelf melt rate depends on thermal forcing from warm, salty, subsurface ocean waters of Atlantic origin (AW), the mixing of AW with fresh, buoyant subglacial discharge at the calving margin, and the shape of the sub-ice-shelf cavity. Subglacial discharge doubled as a result of enhanced ice sheet runoff caused by warmer air temperatures. Ocean thermal forcing has increased due to enhanced advection of AW. Using an Eulerian method, MEaSUREs ice velocity, Operation IceBridge (OIB) ice thickness, and RACMO2.3 surface balance data, we evaluate the ice shelf melt rate in 1978, 1999 and 2010. The melt rate doubled from 1999 to 2010. Using a Lagrangian method with World View imagery, we map the melt rate in detail from 2011 to 2016. We compare the results with 2D simulations from the Massachusetts Institute of Technology general circulation model (MITgcm), at a high spatial resolution (20-m horizontal and 40-m vertical grid spacing), using OIB ice thickness and sub-ice-shelf cavity for years 1978, 1996, 2010 and 2011, combined with in-situ ocean temperature/salinity data from Ocean Melting Greenland (OMG) 2017. We find that winter melt rates are 2 3 times smaller than summer rates and melt rates increase by one order magnitude during the transition from ice shelf termination to near-vertical calving wall termination. As the last remaining bits of floating ice shelf disappear, ice-ocean interaction will therefore play an increasing role in driving the glacier retreat into its marine-based basin. This work was performed under a contract with NASA Cryosphere Program at UC Irvine and Caltech's Jet Propulsion Laboratory.

Electrochemical Genosensing of Circulating Biomarkers

PubMed Central

Campuzano, Susana; Yáñez-Sedeño, Paloma; Pingarrón, José Manuel

2017-01-01

Management and prognosis of diseases requires the measurement in non- or minimally invasively collected samples of specific circulating biomarkers, consisting of any measurable or observable factors in patients that indicate normal or disease-related biological processes or responses to therapy. Therefore, on-site, fast and accurate determination of these low abundance circulating biomarkers in scarcely treated body fluids is of great interest for health monitoring and biological applications. In this field, electrochemical DNA sensors (or genosensors) have demonstrated to be interesting alternatives to more complex conventional strategies. Currently, electrochemical genosensors are considered very promising analytical tools for this purpose due to their fast response, low cost, high sensitivity, compatibility with microfabrication technology and simple operation mode which makes them compatible with point-of-care (POC) testing. In this review, the relevance and current challenges of the determination of circulating biomarkers related to relevant diseases (cancer, bacterial and viral infections and neurodegenerative diseases) are briefly discussed. An overview of the electrochemical nucleic acid–based strategies developed in the last five years for this purpose is given to show to both familiar and non-expert readers the great potential of these methodologies for circulating biomarker determination. After highlighting the main features of the reported electrochemical genosensing strategies through the critical discussion of selected examples, a conclusions section points out the still existing challenges and future directions in this field. PMID:28420103

Variety of RNAs in Peripheral Blood Cells, Plasma, and Plasma Fractions

PubMed Central

Kuligina, Elena V.; Bariakin, Dmitry N.; Kozlov, Vadim V.; Richter, Vladimir A.; Semenov, Dmitry V.

2017-01-01

Human peripheral blood contains RNA in cells and in extracellular membrane vesicles, microvesicles and exosomes, as well as in cell-free ribonucleoproteins. Circulating mRNAs and noncoding RNAs, being internalized, possess the ability to modulate vital processes in recipient cells. In this study, with SOLiD sequencing technology, we performed identification, classification, and quantification of RNAs from blood fractions: cells, plasma, plasma vesicles pelleted at 16,000g and 160,000g, and vesicle-depleted plasma supernatant of healthy donors and non-small cell lung cancer (NSCLC) patients. It was determined that 16,000g blood plasma vesicles were enriched with cell-free mitochondria and with a set of mitochondrial RNAs. The variable RNA set of blood plasma 160,000g pellets reflected the prominent contribution of U1, U5, and U6 small nuclear RNAs' fragments and at the same time was characterized by a remarkable depletion of small nucleolar RNAs. Besides microRNAs, the variety of fragments of mRNAs and snoRNAs dominated in the set of circulating RNAs differentially expressed in blood fractions of NSCLC patients. Taken together, our data emphasize that not only extracellular microRNAs but also circulating fragments of messenger and small nuclear/nucleolar RNAs represent prominent classes of circulating regulatory ncRNAs as well as promising circulating biomarkers for the development of disease diagnostic approaches. PMID:28127559

Evaluating the skills of isotope-enabled general circulation models against in situ atmospheric water vapor isotope observations

NASA Astrophysics Data System (ADS)

Steen-Larsen, H. C.; Risi, C.; Werner, M.; Yoshimura, K.; Masson-Delmotte, V.

2017-01-01

The skills of isotope-enabled general circulation models are evaluated against atmospheric water vapor isotopes. We have combined in situ observations of surface water vapor isotopes spanning multiple field seasons (2010, 2011, and 2012) from the top of the Greenland Ice Sheet (NEEM site: 77.45°N, 51.05°W, 2484 m above sea level) with observations from the marine boundary layer of the North Atlantic and Arctic Ocean (Bermuda Islands 32.26°N, 64.88°W, year: 2012; south coast of Iceland 63.83°N, 21.47°W, year: 2012; South Greenland 61.21°N, 47.17°W, year: 2012; Svalbard 78.92°N, 11.92°E, year: 2014). This allows us to benchmark the ability to simulate the daily water vapor isotope variations from five different simulations using isotope-enabled general circulation models. Our model-data comparison documents clear isotope biases both on top of the Greenland Ice Sheet (1-11‰ for δ18O and 4-19‰ for d-excess depending on model and season) and in the marine boundary layer (maximum differences for the following: Bermuda δ18O = 1‰, d-excess = 3‰; South coast of Iceland δ18O = 2‰, d-excess = 5‰; South Greenland δ18O = 4‰, d-excess = 7‰; Svalbard δ18O = 2‰, d-excess = 7‰). We find that the simulated isotope biases are not just explained by simulated biases in temperature and humidity. Instead, we argue that these isotope biases are related to a poor simulation of the spatial structure of the marine boundary layer water vapor isotopic composition. Furthermore, we specifically show that the marine boundary layer water vapor isotopes of the Baffin Bay region show strong influence on the water vapor isotopes at the NEEM deep ice core-drilling site in northwest Greenland. Our evaluation of the simulations using isotope-enabled general circulation models also documents wide intermodel spatial variability in the Arctic. This stresses the importance of a coordinated water vapor isotope-monitoring network in order to discriminate amongst these model behaviors.

[The Contribution of Vascular Capacity and Blood Volume to Maintain Stable Blood Circulation during General Anesthesia].

PubMed

Shigemi, Kenji

2016-05-01

To maintain proper cardiac preload is one of the most effective procedures for the systemic circulation remaining stable. In particular, the balance between vascular capacity and total blood volume must be maintained within appropriate range by the administration of fluids, blood and/or vasoactive drugs with mean circulatory filling pressure (Pmcf), central venous pressure (CVP) or stroke volume variation (SVV). End-diastolic left ventricular volume (Ved) is theoretically the best index of cardiac preload; however, without transesophageal echocardbalanceiogram we cannot directly monitor Ved during anesthesia. The infused fluid volume remaining in intravascular space, the vascular capacity controlled by autonomic nervous system and/or vasoactive agents, and the unstressed blood volume properly mobilized to excess blood volume are the crucial factors to maintain cardiac output The knowledge of vascular physiology contribute the decision making to manipulate such factors to control blood circulation during general anesthesia. For example, CVP is usually maintained in the narrow range and seems to be stable; however, it must be changed just after the circulatory disturbances, such as acute bleeding, blood transfusion, and fluid infusion, and followed by gradual returning to initial value, because of the solid mechanism to preserve cardiac output

Symmetry, stability, and computation of degenerate lasing modes

NASA Astrophysics Data System (ADS)

Liu, David; Zhen, Bo; Ge, Li; Hernandez, Felipe; Pick, Adi; Burkhardt, Stephan; Liertzer, Matthias; Rotter, Stefan; Johnson, Steven G.

2017-02-01

We present a general method to obtain the stable lasing solutions for the steady-state ab initio lasing theory (SALT) for the case of a degenerate symmetric laser in two dimensions (2D). We find that under most regimes (with one pathological exception), the stable solutions are clockwise and counterclockwise circulating modes, generalizing previously known results of ring lasers to all 2D rotational symmetry groups. Our method uses a combination of semianalytical solutions close to lasing threshold and numerical solvers to track the lasing modes far above threshold. Near threshold, we find closed-form expressions for both circulating modes and other types of lasing solutions as well as for their linearized Maxwell-Bloch eigenvalues, providing a simple way to determine their stability without having to do a full nonlinear numerical calculation. Above threshold, we show that a key feature of the circulating mode is its "chiral" intensity pattern, which arises from spontaneous symmetry breaking of mirror symmetry, and whose symmetry group requires that the degeneracy persists even when nonlinear effects become important. Finally, we introduce a numerical technique to solve the degenerate SALT equations far above threshold even when spatial discretization artificially breaks the degeneracy.

Nonlinear Eddy-Eddy Interactions in Dry Atmospheres Macroturbulence

NASA Astrophysics Data System (ADS)

Ait Chaalal, F.; Schneider, T.

2012-12-01

The statistical moment equations derived from the atmospheric equation of motions are not closed. However neglecting the large-scale eddy-eddy nonlinear interactions in an idealized dry general circulation model (GCM), which is equivalent to truncating the moment equations at the second order, can reproduce some of the features of the general circulation ([1]), highlighting the significance of eddy-mean flow interactions and the weakness of eddy-eddy interactions in atmospheric macroturbulence ([2]). The goal of the present study is to provide new insight into the rôle of these eddy-eddy interactions and discuss the relevance of a simple stochastic parametrization to represent them. We investigate in detail the general circulation in an idealized dry GCM, comparing full simulations with simulations where the eddy-eddy interactions are removed. The radiative processes are parametrized through Newtonian relaxation toward a radiative-equilibrium state with a prescribed equator to pole temperature contrast. A convection scheme relaxing toward a prescribed convective vertical lapse rate mimics some aspects of moist convection. The study is performed over a wide range of parameters covering the planetary rotation rate, the equator to pole temperature contrast and the vertical lapse rate. Particular attention is given to the wave-mean flow interactions and to the spectral budget. It is found that the no eddy-eddy simulations perform well when the baroclinic activity is weaker, for example for lower equator to pole temperature contrasts or higher rotation rates: the mean meridional circulation is well reproduced, with realistic eddy-driven jets and energy-containing eddy length scales of the order of the Rossby deformation radius. For a stronger baroclinic activity the no eddy-eddy model does not achieve a realistic isotropization of the eddies, the meridional circulation is compressed in the meridional direction and secondary eddy-driven jets emerge. In addition, the baroclinic wave activity does not reach the upper troposphere in association with a very weak or absent Rossby wave absorption in the upper subtropical troposphere. Understanding these deficiencies and the rôle of the eddy-eddy nonlinear interactions in determining the mean meridional circulation paves the way to the development of stochastic third order moments parametrizations, to eventually build GCMs that directly solve for the flow statistics and that could provide a deeper understanding of anthropogenic and natural climate changes. [1] O'Gorman, P. A., & Schneider, T. 2007, Geophysical Research Letters, 34, 22801 [2] Schneider, T., and C. C. Walker, 2006, Journal of the Atmospheric Sciences, 63, 1569-1586.

Communicating uncertainty in circulation aspects of climate change

NASA Astrophysics Data System (ADS)

Shepherd, Ted

2017-04-01

The usual way of representing uncertainty in climate change is to define a likelihood range of possible futures, conditioned on a particular pathway of greenhouse gas concentrations (RCPs). Typically these likelihood ranges are derived from multi-model ensembles. However, there is no obvious basis for treating such ensembles as probability distributions. Moreover, for aspects of climate related to atmospheric circulation, such an approach generally leads to large uncertainty and low confidence in projections. Yet this does not mean that the associated climate risks are small. We therefore need to develop suitable ways of communicating climate risk whilst acknowledging the uncertainties. This talk will outline an approach based on conditioning the purely thermodynamic aspects of climate change, concerning which there is comparatively high confidence, on circulation-related aspects, and treating the latter through non-probabilistic storylines.

Fog and rain in the Amazon

PubMed Central

Anber, Usama; Gentine, Pierre; Wang, Shuguang; Sobel, Adam H.

2015-01-01

The diurnal and seasonal water cycles in the Amazon remain poorly simulated in general circulation models, exhibiting peak evapotranspiration in the wrong season and rain too early in the day. We show that those biases are not present in cloud-resolving simulations with parameterized large-scale circulation. The difference is attributed to the representation of the morning fog layer, and to more accurate characterization of convection and its coupling with large-scale circulation. The morning fog layer, present in the wet season but absent in the dry season, dramatically increases cloud albedo, which reduces evapotranspiration through its modulation of the surface energy budget. These results highlight the importance of the coupling between the energy and hydrological cycles and the key role of cloud albedo feedback for climates over tropical continents. PMID:26324902

Impact Of Resolving Submesoscale Features On Modeling The Gulf Stream System

NASA Astrophysics Data System (ADS)

Chassignet, E.; Xu, X.

2016-02-01

Despite being one the best-known circulation pattern of the world ocean, the representation of the Gulf Stream, especially its energetic extension east of the New England Seamounts Chains in the western North Atlantic Ocean, has been a major challenge for ocean general circulation models even at eddy-rich resolutions. Here we show that, for the first time, a simulation of the North Atlantic circulation at 1/50° resolution realistically represents the narrow, energetic jet near 55°W when compared to observations, whereas similarly configured simulations at 1/25° and 1/12° resolution do not. This result highlights the importance of submesoscale features in driving the energetic Gulf Stream extension in the western North Atlantic. The results are discussed in terms of mesoscale and submesoscale energy power spectra.

Fog and rain in the Amazon

DOE PAGES

Anber, Usama; Gentine, Pierre; Wang, Shuguang; ...

2015-08-31

The diurnal and seasonal water cycles in the Amazon remain poorly simulated in general circulation models, exhibiting peak evapotranspiration in the wrong season and rain too early in the day. We show that those biases are not present in cloud-resolving simulations with parameterized large-scale circulation. The difference is attributed to the representation of the morning fog layer, and to more accurate characterization of convection and its coupling with large-scale circulation. The morning fog layer, present in the wet season but absent in the dry season, dramatically increases cloud albedo, which reduces evapotranspiration through its modulation of the surface energy budget.more » Finally, these results highlight the importance of the coupling between the energy and hydrological cycles and the key role of cloud albedo feedback for climates over tropical continents.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anber, Usama; Gentine, Pierre; Wang, Shuguang

The diurnal and seasonal water cycles in the Amazon remain poorly simulated in general circulation models, exhibiting peak evapotranspiration in the wrong season and rain too early in the day. We show that those biases are not present in cloud-resolving simulations with parameterized large-scale circulation. The difference is attributed to the representation of the morning fog layer, and to more accurate characterization of convection and its coupling with large-scale circulation. The morning fog layer, present in the wet season but absent in the dry season, dramatically increases cloud albedo, which reduces evapotranspiration through its modulation of the surface energy budget.more » Finally, these results highlight the importance of the coupling between the energy and hydrological cycles and the key role of cloud albedo feedback for climates over tropical continents.« less

Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society.

PubMed

Sholl, Lynette M; Aisner, Dara L; Allen, Timothy Craig; Beasley, Mary Beth; Cagle, Philip T; Capelozzi, Vera L; Dacic, Sanja; Hariri, Lida P; Kerr, Keith M; Lantuejoul, Sylvie; Mino-Kenudson, Mari; Raparia, Kirtee; Rekhtman, Natasha; Roy-Chowdhuri, Sinchita; Thunnissen, Eric; Tsao, Ming; Vivero, Marina; Yatabe, Yasushi

2016-08-01

Liquid biopsy has received extensive media coverage and has been called the holy grail of cancer detection. Attempts at circulating tumor cell and genetic material capture have been progressing for several years, and recent financially and technically feasible improvements of cell capture devices, plasma isolation techniques, and highly sensitive polymerase chain reaction- and sequencing-based methods have advanced the possibility of liquid biopsy of solid tumors. Although practical use of circulating RNA-based testing has been hindered by the need to fractionate blood to enrich for RNAs, the detection of circulating tumor cells has profited from advances in cell capture technology. In fact, the US Food and Drug Administration has approved one circulating tumor cell selection platform, the CellSearch System. Although the use of liquid biopsy in a patient population with a genomically defined solid tumor may potentially be clinically useful, it currently does not supersede conventional pretreatment tissue diagnosis of lung cancer. Liquid biopsy has not been validated for lung cancer diagnosis, and its lower sensitivity could lead to significant diagnostic delay if liquid biopsy were to be used in lieu of tissue biopsy. Ultimately, notwithstanding the enthusiasm encompassing liquid biopsy, its clinical utility remains unproven.

Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction

NASA Astrophysics Data System (ADS)

Bethel, Kelly; Luttgen, Madelyn S.; Damani, Samir; Kolatkar, Anand; Lamy, Rachelle; Sabouri-Ghomi, Mohsen; Topol, Sarah; Topol, Eric J.; Kuhn, Peter

2014-02-01

Elevated levels of circulating endothelial cells (CECs) occur in response to various pathological conditions including myocardial infarction (MI). Here, we adapted a fluid phase biopsy technology platform that successfully detects circulating tumor cells in the blood of cancer patients (HD-CTC assay), to create a high-definition circulating endothelial cell (HD-CEC) assay for the detection and characterization of CECs. Peripheral blood samples were collected from 79 MI patients, 25 healthy controls and six patients undergoing vascular surgery (VS). CECs were defined by positive staining for DAPI, CD146 and von Willebrand Factor and negative staining for CD45. In addition, CECs exhibited distinct morphological features that enable differentiation from surrounding white blood cells. CECs were found both as individual cells and as aggregates. CEC numbers were higher in MI patients compared with healthy controls. VS patients had lower CEC counts when compared with MI patients but were not different from healthy controls. Both HD-CEC and CellSearch® assays could discriminate MI patients from healthy controls with comparable accuracy but the HD-CEC assay exhibited higher specificity while maintaining high sensitivity. Our HD-CEC assay may be used as a robust diagnostic biomarker in MI patients.

Recent advances in circulating tumor cells and cell-free DNA in metastatic prostate cancer: a review.

PubMed

Parimi, Sunil; Ko, Jenny J

2017-10-01

The treatment landscape of metastatic prostate cancer has changed dramatically over the past five years. As new discoveries are made and further novel therapies become available, there is a heightened urgency to develop biomarkers that can guide prognoses and predict therapy responses. Circulating tumor cells (CTCs) and cell-free circulating tumor DNA (ctDNA) in the blood have emerged as potential promising tumor avatars. Areas covered: In this review, we describe technological breakthroughs and clinical implementation of the CTCs and ctDNA. We also discuss the key challenges that must be overcome before circulating blood-based biomarkers can be universally adopted into the management of patients with metastatic prostate cancer. Expert commentary: Both CTCs and ctDNA have the potential to be incorporated into routine patient care, with increasing numbers of prospective trials incorporating them into clinical designs. CTCs and ctDNA will thus have an increasingly valuable role in augmenting our understanding of prostate cancer at a molecular level, aiding in prognostication of prostate cancer patients, acting as a surrogate for OS in clinical trials, and helping us prioritize our treatment selections by elucidating resistance mechanisms.

Controlling thermal properties of dense gas fluidized beds for concentrated solar power by internal and external solids circulation

NASA Astrophysics Data System (ADS)

Ammendola, Paola; Bareschino, Piero; Chirone, Riccardo; Salatino, Piero; Solimene, Roberto

2017-06-01

Fluidization technology displays a long record of success stories, mostly related to applications to thermal and thermochemical processes, which are fostering extension to novel and relatively unexplored fields. Application of fluidized beds to collection and thermal storage of solar radiation in Concentrated Solar Power (CSP) is one of the most promising, a field which poses challenging issues and great opportunities to fluidization scientists and technologists. The potential of this growing field calls for reconsideration of some of the typical design and operation guidelines and criteria, with the goal of exploiting the inherently good thermal performances of gas-fluidized beds at their best. "Creative" and non-conventional design and operation of fluidized beds, like those based on internal and external solids circulation, may be beneficial to the enhancement of thermal diffusivity and surface-to-bed heat transfer, improving the potential for application in the very demanding context of CSP with thermal energy storage. This paper investigated: i) a fluidized bed configuration with an uneven distribution of the fluidizing gas to promote vortices in the scale of bed height (internal solids circulation); ii) a dual fluidized bed configuration characterized by an external solids circulation achieved by the operation of a riser and a bubbling fluidized bed. CFD simulations showed the hydrodynamics conditions under which the internal solids circulation was established. The hydrodynamic characterization of the external solids circulation was achieved by an experimental study carried out with different cold models. The dual fluidized bed system was optimized in terms of operating conditions and geometrical features of the connections between two fluidized beds.

GCM simulations of cold dry Snowball Earth atmospheres

NASA Astrophysics Data System (ADS)

Voigt, A.; Held, I.; Marotzke, J.

2009-12-01

We use the full-physics atmospheric general circulation model ECHAM5 to investigate cold and virtually dry Snowball Earth atmospheres. These result from specifying sea ice as the surface boundary condition everywhere, corresponding to a frozen aquaplanet, while keeping total solar irradiance at its present-day value of 1365 Wm-2 and setting atmospheric carbon dioxide to 300 ppmv. Here, we present four simulations corresponding to the four possible combinations of enabled or disabled diurnal and seasonal cycles. The aim of this study is twofold. First, we focus on the zonal-mean circulation of Snowball Earth atmospheres, which, due to missing moisture, might constitute an ideal though yet unexplored testbed for theories of atmospheric dynamics. Second, we investigate tropical surface temperatures with an emphasis on the impact of the diurnal and seasonal cycles. This will indicate whether the presence of the diurnal or seasonal cycle would facilitate or anticipate the escape from Snowball Earth conditions when total solar irradiance or atmospheric CO2 levels were increased. The dynamics of the tropical circulation in Snowball Earth atmospheres differs substantially from that in the modern atmosphere. The analysis of the mean zonal momentum budget reveals that the mean flow meridional advection of absolute vorticity is primarily balanced by vertical diffusion of zonal momentum. The contribution of eddies is found to be even smaller than the contribution of mean flow vertical advection of zonal momentum, the latter being usually neglected in theories for the Hadley circulation, at least in its upper tropospheric branch. Suppressing vertical diffusion of horizontal momentum above 850 hPa leads to a stronger Hadley circulation. This behaviour cannot be understood from axisymmetric models of the atmosphere, nor idealized atmospheric general circulation models, which both predict a weakening of the Hadley circulation when the vertical viscosity is decreased globally. We find that enabling the diurnal cycle does not change tropical annual-mean surface temperatures but significantly strengthens the Hadley circulation, which increases by 33% for equinoctial and by 50% during solstitial insolation conditions compared to simulations without diurnal cycle. Including the seasonal cycle results in a ''reversed'' annual-mean Hadley circulation with subsiding motion at the equator and ascending motion around 15N/S, a manifestation of the extreme seasonality of Snowball Earth atmospheres due to the low thermal inertia of the sea-ice surface. The impact of the seasonal cycle on the tropical annual-mean surface is a straightforward consequence of changes in insolation distribution: as annual-mean incoming shortwave radiation at the equator reduces by 18 Wm-2 for enabled seasonal cycle, tropical annual-mean surface temperatures decrease from 221 K to 217 K.

The Dynamics of Hadley Circulation Variability and Change

NASA Astrophysics Data System (ADS)

Davis, Nicholas Alexander

The Hadley circulation exerts a dominant control on the surface climate of earth's tropical belt. Its converging surface winds fuel the tropical rains, while subsidence in the subtropics dries and stabilizes the atmosphere, creating deserts on land and stratocumulus decks over the oceans. Because of the strong meridional gradients in temperature and precipitation in the subtropics, any shift in the Hadley circulation edge could project as major changes in surface climate. While climate model simulations predict an expansion of the Hadley cells in response to greenhouse gas forcings, the mechanisms remain elusive. An analysis of the climatology, variability, and response of the Hadley circulation to radiative forcings in climate models and reanalyses illuminates the broader landscape in which Hadley cell expansion is realized. The expansion is a fundamental response of the atmosphere to increasing greenhouse gas concentrations as it scales with other key climate system changes, including polar amplification, increasing static stability, stratospheric cooling, and increasing global-mean surface temperatures. Multiple measures of the Hadley circulation edge latitudes co-vary with the latitudes of the eddy-driven jets on all timescales, and both exhibit a robust poleward shift in response to forcings. Further, across models there is a robust coupling between the eddy-driving on the Hadley cells and their width. On the other hand, the subtropical jet and tropopause break latitudes, two common observational proxies for the tropical belt edges, lack a strong statistical relationship with the Hadley cell edges and have no coherent response to forcings. This undermines theories for the Hadley cell width predicated on angular momentum conservation and calls for a new framework for understanding Hadley cell expansion. A numerical framework is developed within an idealized general circulation model to isolate the mean flow and eddy responses of the global atmosphere to radiative forcings. It is found that it is primarily the eddy response to greenhouse-gas-like forcings that causes Hadley cell expansion. However, the mean flow changes in the Hadley circulation itself crucially mediate this eddy response such that the full response comes about due to eddy-mean flow interactions. A theoretical scaling for the Hadley cell width based on moist static energy is developed to provide an improved framework to understand climate change responses of the general circulation. The scaling predicts that expansion is driven by increases in the surface latent heat flux and the width of the rising branch of the circulation and opposed by increases in tropospheric radiative cooling. A reduction in subtropical moist static energy flux divergence by the eddies is key, as it tilts the energetic balance in favor of expansion.

Heat flow evidence for hydrothermal circulation in the volcanic basement of subducting plates

NASA Astrophysics Data System (ADS)

Harris, R. N.; Spinelli, G. A.; Fisher, A. T.

2017-12-01

We summarize and interpret evidence for hydrothermal circulation in subducting oceanic basement from the Nankai, Costa Rica, south central Chile, Haida Gwaii, and Cascadia margins and explore the influence of hydrothermal circulation on plate boundary temperatures in these settings. Heat flow evidence for hydrothermal circulation in the volcanic basement of incoming plates includes: (a) values that are well below conductive (lithospheric) predictions due to advective heat loss, and (b) variability about conductive predictions that cannot be explained by variations in seafloor relief or thermal conductivity. We construct thermal models of these systems that include an aquifer in the upper oceanic crust that enhances heat transport via a high Nusselt number proxy for hydrothermal circulation. At the subduction zones examined, patterns of seafloor heat flow are not well fit by purely conductive simulations, and are better explained by simulations that include the influence of hydrothermal circulation. This result is consistent with the young basement ages (8-35 Ma) of the incoming igneous crust at these sites as well as results from global heat flow analyses showing a significant conductive heat flow deficit for crustal ages less than 65 Ma. Hydrothermal circulation within subducting oceanic basement can have a profound influence on temperatures close to the plate boundary and, in general, leads to plate boundary temperatures that are cooler than those where fluid flow does not occur. The magnitude of cooling depends on the permeability structure of the incoming plate and the evolution of permeability with depth and time. Resolving complex relationships between subduction processes, the permeability structure in the ocean crust, and the dynamics of hydrothermal circulation remains an interdisciplinary frontier.

Patient's Guide to Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

MedlinePlus

Skip to main content American Heart Association Science Volunteer Warning Signs Search for this keyword Search Advanced Search Donate Home About this Journal Editorial Board General Statistics Circulation Doodle Doodle Gallery ...

Summertime land-sea thermal contrast and atmospheric circulation over East Asia in a warming climate—Part I: Past changes and future projections

NASA Astrophysics Data System (ADS)

Kamae, Youichi; Watanabe, Masahiro; Kimoto, Masahide; Shiogama, Hideo

2014-11-01

Land-sea surface air temperature (SAT) contrast, an index of tropospheric thermodynamic structure and dynamical circulation, has shown a significant increase in recent decades over East Asia during the boreal summer. In Part I of this two-part paper, observational data and the results of transient warming experiments conducted using coupled atmosphere-ocean general circulation models (GCMs) are analyzed to examine changes in land-sea thermal contrast and the associated atmospheric circulation over East Asia from the past to the future. The interannual variability of the land-sea SAT contrast over the Far East for 1950-2012 was found to be tightly coupled with a characteristic tripolar pattern of tropospheric circulation over East Asia, which manifests as anticyclonic anomalies over the Okhotsk Sea and around the Philippines, and a cyclonic anomaly over Japan during a positive phase, and vice versa. In response to CO2 increase, the cold northeasterly winds off the east coast of northern Japan and the East Asian rainband were strengthened with the circulation pattern well projected on the observed interannual variability. These results are commonly found in GCMs regardless of future forcing scenarios, indicating the robustness of the East Asian climate response to global warming. The physical mechanisms responsible for the increase of the land-sea contrast are examined in Part II.

Observational and modeling studies of heat, moisture, precipitation, and global-scale circulation patterns

NASA Technical Reports Server (NTRS)

Vincent, Dayton G.; Robertson, Franklin

1993-01-01

The research sponsored by this grant is a continuation and an extension of the work conducted under a previous contract, 'South Pacific Convergence Zone and Global-Scale Circulations'. In the prior work, we conducted a detailed investigation of the South Pacific convergence zone (SPCZ), and documented many of its significant features and characteristics. We also conducted studies of its interaction with global-scale circulation features through the use of both observational and modeling studies. The latter was accomplished toward the end of the contract when Dr. James Hurrell, then a Ph.D. candidate, successfully ported the NASA GLA general circulation model (GCM) to Purdue University. In our present grant, we have expanded our previous research to include studies of other convectively-driven circulation systems in the tropics besides the SPCZ. Furthermore, we have continued to examine the relationship between these convective systems and global-scale circulation patterns. Our recent research efforts have focused on three objectives: (1) determining the periodicity of large-scale bands of organized convection in the tropics, primarily synoptic to intraseasonal time scales in the Southern Hemisphere; (2) examining the relative importance of tropical versus mid-latitude forcing for Southern Hemisphere summertime subtropical jets, particularly over the Pacific Ocean; and (3) estimating tropical precipitation, especially over oceans, using observational and budget methods. A summary list of our most significant accomplishments in the past year is given.

Block-circulant matrices with circulant blocks, Weil sums, and mutually unbiased bases. II. The prime power case

DOE Office of Scientific and Technical Information (OSTI.GOV)

Combescure, Monique

2009-03-15

In our previous paper [Combescure, M., 'Circulant matrices, Gauss sums and the mutually unbiased bases. I. The prime number case', Cubo A Mathematical Journal (unpublished)] we have shown that the theory of circulant matrices allows to recover the result that there exists p+1 mutually unbiased bases in dimension p, p being an arbitrary prime number. Two orthonormal bases B, B{sup '} of C{sup d} are said mutually unbiased if for all b(set-membership sign)B, for all b{sup '}(set-membership sign)B{sup '} one has that |b{center_dot}b{sup '}|=1/{radical}(d) (b{center_dot}b{sup '} Hermitian scalar product in C{sup d}). In this paper we show that the theorymore » of block-circulant matrices with circulant blocks allows to show very simply the known result that if d=p{sup n} (p a prime number and n any integer) there exists d+1 mutually unbiased bases in C{sup d}. Our result relies heavily on an idea of Klimov et al. [''Geometrical approach to the discrete Wigner function,'' J. Phys. A 39, 14471 (2006)]. As a subproduct we recover properties of quadratic Weil sums for p{>=}3, which generalizes the fact that in the prime case the quadratic Gauss sum properties follow from our results.« less

Noninvasive prenatal diagnosis for single gene disorders.

PubMed

Allen, Stephanie; Young, Elizabeth; Bowns, Benjamin

2017-04-01

Noninvasive prenatal diagnosis for single gene disorders is coming to fruition in its clinical utility. The presence of cell-free DNA in maternal plasma has been recognized for many years, and a number of applications have developed from this. Noninvasive prenatal diagnosis for single gene disorders has lagged behind due to complexities of technology development, lack of investment and the need for validation samples for rare disorders. Publications are emerging demonstrating a variety of technical approaches and feasibility of clinical application. Techniques for analysis of cell-free DNA including digital PCR, next-generation sequencing and relative haplotype dosage have been used most often for assay development. Analysis of circulating fetal cells in the maternal blood is still being investigated as a viable alternative and more recently transcervical trophoblast cells. Studies exploring ethical and social issues are generally positive but raise concerns around the routinization of prenatal testing. Further work is necessary to make testing available to all patients with a pregnancy at risk of a single gene disorder, and it remains to be seen if the development of more powerful technologies such as isolation and analysis of single cells will shift the emphasis of noninvasive prenatal diagnosis. As testing becomes possible for a wider range of conditions, more ethical questions will become relevant.

Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology.

PubMed

Gesenhues, Jonas; Hein, Marc; Ketelhut, Maike; Habigt, Moriz; Rüschen, Daniel; Mechelinck, Mare; Albin, Thivaharan; Leonhardt, Steffen; Schmitz-Rode, Thomas; Rossaint, Rolf; Autschbach, Rüdiger; Abel, Dirk

2017-04-01

Computational models of biophysical systems generally constitute an essential component in the realization of smart biomedical technological applications. Typically, the development process of such models is characterized by a great extent of collaboration between different interdisciplinary parties. Furthermore, due to the fact that many underlying mechanisms and the necessary degree of abstraction of biophysical system models are unknown beforehand, the steps of the development process of the application are iteratively repeated when the model is refined. This paper presents some methods and tools to facilitate the development process. First, the principle of object-oriented (OO) modeling is presented and the advantages over classical signal-oriented modeling are emphasized. Second, our self-developed simulation tool ModeliChart is presented. ModeliChart was designed specifically for clinical users and allows independently performing in silico studies in real time including intuitive interaction with the model. Furthermore, ModeliChart is capable of interacting with hardware such as sensors and actuators. Finally, it is presented how optimal control methods in combination with OO models can be used to realize clinically motivated control applications. All methods presented are illustrated on an exemplary clinically oriented use case of the artificial perfusion of the systemic circulation.

The general circulation in the eastern Algerian subbasin inferred from the ELISA experiment

NASA Astrophysics Data System (ADS)

Aubertin, E.; Millot, C.; Taupier-Letage, I.; Albérola, C.; Robin, S.; Font, J.

2003-04-01

About 40 current meters were set at nominal depths of 100, 350, 1000, 1800 and 2700 m on 9 moorings in the eastern Algerian subbasin from July 1997 to July 1998 during the ELISA operation (http://www.com.univ-mrs.fr/ELISA/). Most moorings were located on the 2800-m isobath, and all data sets were checked using the tidal currents analysis (Albérola et al., 1995). They allow i) confirming known features about the alongslope circulation, ii) proving that Algerian Eddies (AE's) can extend down to the bottom and iii) evidencing an anticlockwise circulation at intermediate and greater depths in the whole subbasin. i) At about 50 km from the Algerian and Sardinian coastlines, the general circulation is clearly alongslope and anticlockwise at all depths, as during previous experiments (Millot, 1994; Bouzinac et al., 1999). It is also confirmed that alongslope currents are generally larger closer to the bottom than at intermediate depths, with most annual means from 350 to 2700 m in the range 3-6 cm/s, up to about 10 cm/s at 2700 m on one mooring. This permanent (unless disturbed by AE's, see ii)) and extremely large circulation is still not well simulated by the general circulation models, which still prevents from getting a correct understanding of the functioning of the whole western basin. ii) During the experiment, three 100-200 km AE's (96-1, 97-1, and 98-2) have been identified following the anticlockwise circuit that was first specified by Fuda et al. (2000) in the study area. One of them (96-1), which had a lifetime of about 3 years (Puillat et al., 2002), remained stationary during about 5 months and was well sampled at that time by 3 moorings at least. This AE, as all AE's previously sampled (Millot et al., 1997; Ruiz et al., 2002), was clearly an anticyclone, not only in the surface AW layer, but also in the whole deep layer (i.e. down to 2800 m). Alongslope, the eddy-associated current is opposed to the general circulation at all depths, and can even be larger. When it started propagating again, 96-1 still extended over the whole depth at least during a couple of months, before markedly reducing its signature. Contrary to what is said by Testor (2002), the lagrangian floats that were launched at about 600 m within 96-1 at the beginning of the experiment did confirm the anticyclonic rotation in the intermediate layer at least (data provided by J.C. Gascard and P. Testor). These observations are seemingly consistent with many other float trajectories at 1200 and 1950 m (U. Send, personal communication) that clearly evidence mesoscale anticyclonic loops. The ELISA time series, as well as the MEDIPROD-5 ones (Millot et al., 1997) clearly confirm that the current associated with an AE has the same amplitude and phase within the whole deep layer. This is consistent with laboratory experiments and with the (sole?) hypothesis of Obaton et al. (2000) that the deep circulation within an AE is forced by a pressure effect from the surface layer. However, theoretical analyses and numerical models are, to our knowledge, not available yet to confirm this hypothesis and / or explain the actual processes yet. iii) Moorings located in the middle of the eastern Algerian subbasin, as well as the float trajectories mentioned above in the whole subbasin (south of about 39 °N), do account for an overall anticlockwise circulation in the whole deep layer. This circulation roughly corresponds to the circuit of the AE's described above. It must be noticed that most of this closed circulation is embedded in the overall alongslope circulation (from Algeria to Sardinia), thus being associated with relatively large speeds increasing with depth (as described above). Closure of this circuit (roughly from Sardinia to Balearic Islands and Algeria) do reveal very different characteristics with annual means lower than 3 cm/s decreasing with depth. Reasons for such a well defined, although not permanent, closed circulation in the eastern Algerian subbasin, and relationships with both the bathymetry and the AE's dynamics are under study Albérola C., S. Rousseau, C. Millot, M. Astraldi, J. Font, J. Garcia-Lafuente, G.P. Gasparini, U. Send and A. Vangriesheim, 1995. Tidal currents in the interior of the Western Mediterranean Sea. Oceanol. Acta, 18, 2, 273-284. Bouzinac C., J. Font and C. Millot, 1999. Hydrology and currents observed in the channel of Sardinia during the PRIMO-1 experiment from November 1993 to October 1994. J. Mar. Systems, 20, 1-4, 333-355. Fuda J.-L., C. Millot, I. Taupier-Letage, U. Send and J.M. Bocognano, 2000. XBT monitoring of a meridian section across the Western Mediterranean Sea. Deep-Sea Res., I 47, 2191-2218. Millot C., 1994. Models and data: a synergetic approach in the western Mediterranean Sea. Erice School Proceedings,"Ocean Processes in Climate Dynamics: Global and Mediterranean Examples", P. Malanotte-Rizzoli and A.R. Robinson eds, 407-425. Millot C., I. Taupier-Letage and M. Benzohra, 1997. Circulation off Algeria inferred from the Médiprod-5 current meters. Deep-Sea Res., 44, 9-10, 1467-1495. Obaton D., C. Millot, G. Chabert D'Hières and I. Taupier-Letage, 2000. The Algerian Current: comparisons between in situ and laboratory measurements. Deep-Sea Res., I 47, 2159-2190. Puillat I., I.Taupier-Letage and C. Millot. Algerian eddies lifetimes can near 3 years, 2002. Journal of Marine Syst., 31, 4, 245-259. Ruiz S., J. Font, M.Emelianov, J. Isern-Fontanet, C. Millot and I. Taupier-Letage, 2002. Deep structure of an open sea eddy in the Algerian Basin. J. Mar. Sys., 33-34, 179-195. Testor P., 2002. Etude lagrangienne de circulations tourbillonnaires de subméso et méso échelle en Méditerranée occidentale sur la base d'observations et de simulations numériques : phénoménologie et interaction avec la circulation générale. Thèse de Doctorat d'Université, Paris 6.

A local-circulation model for Darrieus vertical-axis wind turbines

NASA Astrophysics Data System (ADS)

Masse, B.

1986-04-01

A new computational model for the aerodynamics of the vertical-axis wind turbine is presented. Based on the local-circulation method generalized for curved blades, combined with a wake model for the vertical-axis wind turbine, it differs markedly from current models based on variations in the streamtube momentum and vortex models using the lifting-line theory. A computer code has been developed to calculate the loads and performance of the Darrieus vertical-axis wind turbine. The results show good agreement with experimental data and compare well with other methods.

The Effect of Enhanced Diabatic Heating on Stratospheric Circulation. Degree awarded by Michigan University, 1997.

NASA Technical Reports Server (NTRS)

Kleb, Mary M.

1997-01-01

The objective of this research focuses on the stratospheric dynamical response to the increase in aerosol loading and subsequent enhanced diabatic heating resulting from the eruption of Mt. Pinatubo. The Langley research Center three dimensional general circulation model and modifications made to that model for this study are described (addition of hydrogen fluoride tracer and diabatic heating enhancement). Unperturbed hydrogen fluoride distribution is compared to the hydrogen fluoride distribution measured by HALOE. A comparison of control and perturbed model runs is presented.

"What Controls the Structure and Stability of the Ocean Meridional Overturning Circulation: Implications for Abrupt Climate Change?"

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fedorov, Alexey

2013-11-23

The central goal of this research project is to understand the properties of the ocean meridional overturning circulation (MOC) – a topic critical for understanding climate variability and stability on a variety of timescales (from decadal to centennial and longer). Specifically, we have explored various factors that control the MOC stability and decadal variability in the Atlantic and the ocean thermal structure in general, including the possibility abrupt climate change. We have also continued efforts on improving the performance of coupled ocean-atmosphere GCMs.

Apparatus for controlling nuclear core debris

DOEpatents

Jones, Robert D.

1978-01-01

Nuclear reactor apparatus for containing, cooling, and dispersing reactor debris assumed to flow from the core area in the unlikely event of an accident causing core meltdown. The apparatus includes a plurality of horizontally disposed vertically spaced plates, having depressions to contain debris in controlled amounts, and a plurality of holes therein which provide natural circulation cooling and a path for debris to continue flowing downward to the plate beneath. The uppermost plates may also include generally vertical sections which form annular-like flow areas which assist the natural circulation cooling.

Global atmospheric circulation statistics, 1000-1 mb

NASA Technical Reports Server (NTRS)

Randel, William J.

1992-01-01

The atlas presents atmospheric general circulation statistics derived from twelve years (1979-90) of daily National Meteorological Center (NMC) operational geopotential height analyses; it is an update of a prior atlas using data over 1979-1986. These global analyses are available on pressure levels covering 1000-1 mb (approximately 0-50 km). The geopotential grids are a combined product of the Climate Analysis Center (which produces analyses over 70-1 mb) and operational NMC analyses (over 1000-100 mb). Balance horizontal winds and hydrostatic temperatures are derived from the geopotential fields.

The Impact of Automation on Libraries. Final Report.

ERIC Educational Resources Information Center

Cline, Hugh F.; Sinnott, Loraine T.

This project examined a series of alternative policies for the management and funding of university libraries as they adopt and adapt to various information science technologies to accomplish the functions of acquisitions, cataloging, circulation, and reference services. Comparative case studies were completed at the University of Chicago,…

Microform Publishing: Salvation for Short-Run Periodicals?

ERIC Educational Resources Information Center

Bovee, Warren G.

Micropublishing, a new technology, has provided small-circulation periodicals, which have little advertising revenues, with an alternative to escalating costs of traditional paper publication. The process of micropublishing which is most serviceable for short-run periodicals involves the use of microfiche--a small piece of film which can contain…

Government-Microsoft Partnerships: Supranational Formulation in Private and Public Policy

ERIC Educational Resources Information Center

Cardoso, Clementina Marques

2008-01-01

This article argues that the framework for the governance of technological knowledge and skills that is formulated for national consumption emerges from a supranational terrain of politics outside the jurisdiction of national and European parliamentary activity and scrutiny. Traditionally understood as a space where ideas circulate and initiatives…

7 CFR 764.102 - General limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF... flow, circulation, or reach of water, except in the case of activity related to the maintenance of... contributes to the farm. ...

Venus general atmosphere circulation described by Pioneer

NASA Technical Reports Server (NTRS)

1981-01-01

The predominant weather pattern for Venus is described. Wind directions and wind velocities are given. Possible driving forces of the winds are presented and include solar heating, planetary rotation, and the greenhouse effect.

Rotating-fluid experiments with an atmospheric general circulation model

NASA Technical Reports Server (NTRS)

Geisler, J. E.; Pitcher, E. J.; Malone, R. C.

1983-01-01

In order to determine features of rotating fluid flow that are dependent on the geometry, rotating annulus-type experiments are carried out with a numerical model in spherical coordinates. Rather than constructing and testing a model expressly for this purpose, it is found expedient to modify an existing general circulation model of the atmosphere by removing the model physics and replacing the lower boundary with a uniform surface. A regime diagram derived from these model experiments is presented; its major features are interpreted and contrasted with the major features of rotating annulus regime diagrams. Within the wave regime, a narrow region is found where one or two zonal wave numbers are dominant. The results reveal no upper symmetric regime; wave activity at low rotation rates is thought to be maintained by barotropic rather than baroclinic processes.

Seasonal simulations of the planetary boundary layer and boundary-layer stratocumulus clouds with a general circulation model

NASA Technical Reports Server (NTRS)

Randall, D. A.; Abeles, J. A.; Corsetti, T. G.

1985-01-01

The formulation of the planetary boundary layer (PBL) and stratocumulus parametrizations in the UCLA general circulation model (GCM) are briefly summarized, and extensive new results are presented illustrating some aspects of the simulated seasonal changes of the global distributions of PBL depth, stratocumulus cloudiness, cloud-top entrainment instability, the cumulus mass flux, and related fields. Results from three experiments designed to reveal the sensitivity of the GCM results to aspects of the PBL and stratocumulus parametrizations are presented. The GCM results show that the layer cloud instability appears to limit the extent of the marine subtropical stratocumulus regimes, and that instability frequently occurs in association with cumulus convection over land. Cumulus convection acts as a very significant sink of PBL mass throughout the tropics and over the midlatitude continents in winter.

The parameterization of the planetary boundary layer in the UCLA general circulation model - Formulation and results

NASA Technical Reports Server (NTRS)

Suarez, M. J.; Arakawa, A.; Randall, D. A.

1983-01-01

A planetary boundary layer (PBL) parameterization for general circulation models (GCMs) is presented. It uses a mixed-layer approach in which the PBL is assumed to be capped by discontinuities in the mean vertical profiles. Both clear and cloud-topped boundary layers are parameterized. Particular emphasis is placed on the formulation of the coupling between the PBL and both the free atmosphere and cumulus convection. For this purpose a modified sigma-coordinate is introduced in which the PBL top and the lower boundary are both coordinate surfaces. The use of a bulk PBL formulation with this coordinate is extensively discussed. Results are presented from a July simulation produced by the UCLA GCM. PBL-related variables are shown, to illustrate the various regimes the parameterization is capable of simulating.

Sea ice simulations based on fields generated by the GLAS GCM. [Goddard Laboratory for Atmospheric Sciences General Circulation Model

NASA Technical Reports Server (NTRS)

Parkinson, C. L.; Herman, G. F.

1980-01-01

The GLAS General Circulation Model (GCM) was applied to the four-month simulation of the thermodynamic part of the Parkinson-Washington sea ice model using atmospheric boundary conditions. The sea ice thickness and distribution were predicted for the Jan. 1-Apr. 30 period using the GCM-fields of solar and infrared radiation, specific humidity and air temperature at the surface, and snow accumulation; the sensible heat and evaporative surface fluxes were consistent with the ground temperatures produced by the ice model and the air temperatures determined by the atmospheric concept. It was concluded that the Parkinson-Washington sea ice model results in acceptable ice concentrations and thicknesses when used with GLAS GCM for the Jan.-Apr. period suggesting the feasibility of fully coupled ice-atmosphere simulations with these two approaches.

Stable water isotope behavior during the last glacial maximum: A general circulation model analysis

NASA Technical Reports Server (NTRS)

Jouzel, Jean; Koster, Randal D.; Suozzo, Robert J.; Russell, Gary L.

1994-01-01

Global water isotope geochemisty during the last glacial maximum (LGM) is simulated with an 8 deg x 10 deg atmospheric general circulation model (GCM). The simulation results suggest that the spatial delta O-18/temperature relationships observed for the present day and LGM climates are very similar. Furthermore, the temporal delta O-18/temperature relationship is similar to the present-day spatial relationship in regions for which the LGM/present-day temperature change is significant. This helps justify the standard practice of applying the latter to the interpretation of paleodata, despite the possible influence of other factors, such as changes in the evaportive sources of precipitation or in the seasonality of precipitation. The model suggests, for example, that temperature shifts inferred from ice core data may differ from the true shifts by only about 30%.

The balance of kinetic and total energy simulated by the OSU two-level atmospheric general circulation model for January and July

NASA Technical Reports Server (NTRS)

Wang, J.-T.; Gates, W. L.; Kim, J.-W.

1984-01-01

A three-year simulation which prescribes seasonally varying solar radiation and sea surface temperature is the basis of the present study of the horizontal structure of the balances of kinetic and total energy simulated by Oregon State University's two-level atmospheric general circulation model. Mechanisms responsible for the local energy changes are identified, and the energy balance requirement's fulfilment is examined. In January, the vertical integral of the total energy shows large amounts of external heating over the North Pacific and Atlantic, together with cooling over most of the land area of the Northern Hemisphere. In July, an overall seasonal reversal is found. Both seasons are also characterized by strong energy flux divergence in the tropics, in association with the poleward transport of heat and momentum.

Simulated influences of Lake Agassiz on the climate of central North America 11,000 years ago

USGS Publications Warehouse

Hostetler, S.W.; Bartlein, P.J.; Clark, P.U.; Small, E.E.; Solomon, A.M.

2000-01-01

Eleven thousand years ago, large lakes existed in central and eastern North America along the margin of the Laurentide Ice Sheet. The large-scale North American climate at this time has been simulated with atmospheric general circulation models, but these relatively coarse global models do not resolve potentially important features of the mesoscale circulation that arise from interactions among the atmosphere, ice sheet, and proglacial lakes. Here we present simulations of the climate of central and eastern North America 11,000 years ago with a high-resolution, regional climate model nested within a general circulation model. The simulated climate is in general agreement with that inferred from palaeoecological evidence. Our experiments indicate that through mesoscale atmospheric feedbacks, the annual delivery of moisture to the Laurentide Ice Sheet was diminished at times of a large, cold Lake Agassiz relative to periods of lower lake stands. The resulting changes in the mass balance of the ice sheet may have contributed to fluctuations of the ice margin, thus affecting the routing of fresh water to the North Atlantic Ocean. A retreating ice margin during periods of high lake level may have opened an outlet for discharge of Lake Agassiz into the North Atlantic. A subsequent advance of the ice margin due to greater moisture delivery associated with a low lake level could have dammed the outlet, thereby reducing discharge to the North Atlantic. These variations may have been decisive in causing the Younger Dryas cold even.

Intra-seasonal rainfall characteristics and their importance to the seasonal prediction problem

NASA Astrophysics Data System (ADS)

Tennant, Warren J.; Hewitson, Bruce C.

2002-07-01

Daily station rainfall data in South Africa from 1936 to 1999 are combined into homogeneous rainfall regions using Ward's clustering method. Various rainfall characteristics are calculated for the summer season, defined as December to February. These include seasonal rainfall total, region-average number of station rain days exceeding 1 and 20 mm, region-average of periods between rain days at stations >1 and >20 mm, region-average of wet spell length (sequential days of station rainfall >1 and >20 mm), correlation of daily station rainfall within a region and correlation of seasonal station rainfall anomalies within a region.Rank-ordered rainfall characteristic data generally form an s-shaped curve, and significance testing of discontinuities in these curves suggests that normal rainfall conditions in South Africa consist of a combined middle three quintiles separated from the outer quintiles, rather than the traditional middle tercile.The relationships between the various rainfall characteristics show that seasons with a high total rainfall generally have a higher number of heavy rain days (>20 mm) and not necessarily an increase in light rain days. The length of the period between rain days has a low correlation to season totals, demonstrating that seasons with a high total rainfall may still contain prolonged dry periods. These additional rainfall characteristics are important to end-users, and the analysis undertaken here offers a valuable starting point for seeking physical relationships between rainfall characteristics and the general circulation. Preliminary studies show that the vertical mean wind is related to rainfall characteristics in South Africa. Given that general circulation models capture this part of the circulation adequately, seasonal forecasts of rainfall characteristics become plausible.

Interannual Variability of Martian Global Dust Storms: Simulations with a Low-Order Model of the General Circulation

NASA Technical Reports Server (NTRS)

Pankine, A. A.; Ingersoll, Andrew P.

2002-01-01

We present simulations of the interannual variability of martian global dust storms (GDSs) with a simplified low-order model (LOM) of the general circulation. The simplified model allows one to conduct computationally fast long-term simulations of the martian climate system. The LOM is constructed by Galerkin projection of a 2D (zonally averaged) general circulation model (GCM) onto a truncated set of basis functions. The resulting LOM consists of 12 coupled nonlinear ordinary differential equations describing atmospheric dynamics and dust transport within the Hadley cell. The forcing of the model is described by simplified physics based on Newtonian cooling and Rayleigh friction. The atmosphere and surface are coupled: atmospheric heating depends on the dustiness of the atmosphere, and the surface dust source depends on the strength of the atmospheric winds. Parameters of the model are tuned to fit the output of the NASA AMES GCM and the fit is generally very good. Interannual variability of GDSs is possible in the IBM, but only when stochastic forcing is added to the model. The stochastic forcing could be provided by transient weather systems or some surface process such as redistribution of the sand particles in storm generating zones on the surface. The results are sensitive to the value of the saltation threshold, which hints at a possible feedback between saltation threshold and dust storm activity. According to this hypothesis, erodable material builds up its a result of a local process, whose effect is to lower the saltation threshold until a GDS occurs. The saltation threshold adjusts its value so that dust storms are barely able to occur.

Estimating climate change, CO2 and technology development effects on wheat yield in northeast Iran

NASA Astrophysics Data System (ADS)

Bannayan, M.; Mansoori, H.; Rezaei, E. Eyshi

2014-04-01

Wheat is the main food for the majority of Iran's population. Precise estimation of wheat yield change in future is essential for any possible revision of management strategies. The main objective of this study was to evaluate the effects of climate change, CO2 concentration, technology development and their integrated effects on wheat production under future climate change. This study was performed under two scenarios of the IPCC Special Report on Emission Scenarios (SRES): regional economic (A2) and global environmental (B1). Crop production was projected for three future time periods (2020, 2050 and 2080) in comparison with a baseline year (2005) for Khorasan province located in the northeast of Iran. Four study locations in the study area included Mashhad, Birjand, Bojnourd and Sabzevar. The effect of technology development was calculated by fitting a regression equation between the observed wheat yields against historical years considering yield potential increase and yield gap reduction as technology development. Yield relative increase per unit change of CO2 concentration (1 ppm-1) was considered 0.05 % and was used to implement the effect of elevated CO2. The HadCM3 general circulation model along with the CSM-CERES-Wheat crop model were used to project climate change effects on wheat crop yield. Our results illustrate that, among all the factors considered, technology development provided the highest impact on wheat yield change. Highest wheat yield increase across all locations and time periods was obtained under the A2 scenario. Among study locations, Mashhad showed the highest change in wheat yield. Yield change compared to baseline ranged from -28 % to 56 % when the integration of all factors was considered across all locations. It seems that achieving higher yield of wheat in future may be expected in northeast Iran assuming stable improvements in production technology.

Estimating climate change, CO2 and technology development effects on wheat yield in northeast Iran.

PubMed

Bannayan, M; Mansoori, H; Rezaei, E Eyshi

2014-04-01

Wheat is the main food for the majority of Iran's population. Precise estimation of wheat yield change in future is essential for any possible revision of management strategies. The main objective of this study was to evaluate the effects of climate change, CO2 concentration, technology development and their integrated effects on wheat production under future climate change. This study was performed under two scenarios of the IPCC Special Report on Emission Scenarios (SRES): regional economic (A2) and global environmental (B1). Crop production was projected for three future time periods (2020, 2050 and 2080) in comparison with a baseline year (2005) for Khorasan province located in the northeast of Iran. Four study locations in the study area included Mashhad, Birjand, Bojnourd and Sabzevar. The effect of technology development was calculated by fitting a regression equation between the observed wheat yields against historical years considering yield potential increase and yield gap reduction as technology development. Yield relative increase per unit change of CO2 concentration (1 ppm(-1)) was considered 0.05 % and was used to implement the effect of elevated CO2. The HadCM3 general circulation model along with the CSM-CERES-Wheat crop model were used to project climate change effects on wheat crop yield. Our results illustrate that, among all the factors considered, technology development provided the highest impact on wheat yield change. Highest wheat yield increase across all locations and time periods was obtained under the A2 scenario. Among study locations, Mashhad showed the highest change in wheat yield. Yield change compared to baseline ranged from -28 % to 56 % when the integration of all factors was considered across all locations. It seems that achieving higher yield of wheat in future may be expected in northeast Iran assuming stable improvements in production technology.

Impact of Stratospheric Ozone Distribution on Features of Tropospheric Circulation

NASA Astrophysics Data System (ADS)

Barodka, Siarhei; Krasouski, Aliaksandr; Mitskevich, Yaroslav; Shalamyansky, Arkady

2016-04-01

In this work we study connections between stratospheric ozone distribution and general circulation patterns in the troposphere and aim to investigate the causal relationship between them, including the practical side of the influence of stratospheric ozone on tropospheric medium-range weather and regional climate. Analysis of several decades of observational data, which has been performed at the A.I. Voeikov Main Geophysical Observatory, suggests a clear relation between the stratospheric ozone distribution, upper stratospheric temperature field and planetary-scale air-masses boundaries in the troposphere [1]. Furthermore, it has been shown that each global air-mass, which can be attributed to the corresponding circulation cell in a conceptual model of tropospheric general circulation, has a distinct "regime" of ozone vertical distribution in the stratosphere [1-3]. Proceeding from atmospheric reanalyses combined with satellite and ground-based observations, we study time evolution of the upper-level frontal zones (stationary fronts) with the relevant jet streams, which can be treated as boundaries of global air-masses, in connection with the tropopause height and distribution of ozone in the stratosphere. For that, we develop an algorithm for automated identification of jet streams, stationary fronts and tropopause surface from gridded data (reanalyses or modelling results), and apply it for several cases associated with rapid changes in the stratospheric temperature and ozone fields, including SSW events over Eastern Siberia. Aiming to study the causal relationship between the features of tropospheric circulation and changes in the stratospheric ozone field, we estimate the time lag between these categories of processes on different time scales. Finally, we discuss the possibility to use the elementary circulation mechanisms classification (by B.L. Dzerdzeevski) in connection with analysis of the stratospheric ozone field and the relevant stratosphere-troposphere interactions. [1] Shalamyansky A.M., Proceedings of Voeikov MGO, St. Petersburg, V. 568, pp. 173-194, 2013 [2] R.D. Hudson et al, J. Atmos. Sci., V. 60, pp. 1669-1677, 2003 [3] R.D. Hudson et al, Atmos. Chem. Phys., V. 6, pp. 5183-5191, 2006

Dust sources and atmospheric circulation in concert controlling Saharan dust emission and transport towards the Western Mediterranean Basin

NASA Astrophysics Data System (ADS)

Schepanski, Kerstin; Mallet, Marc; Heinold, Bernd; Ulrich, Max

2017-04-01

Dust transported from north African source regions towards Europe is a ubiquitous phenomenon in the Mediterranean region, a geographic region that is in part densely populated. Besides its impacts on the atmospheric radiation budget, dust suspended in the atmosphere results in reduced air quality, which is generally sensed as a reduction in quality of life. Furthermore, the exposure to dust aerosols enhances the prevalence of respiratory diseases, which reduces the general human wellbeing, and ultimately results in an increased loss of working hours due to illness and hospitalization rates. Characteristics of the atmospheric dust life cycle that determine dust transport will be presented with focus on the ChArMEx special observation period in June and July 2013 using the atmosphere-dust model COSMO-MUSCAT (COSMO: Consortium for Small-scale MOdeling; MUSCAT: MUltiScale Chemistry Aerosol Transport Model). Modes of atmospheric circulation were identified from empirical orthogonal function (EOF) analysis of the geopotential height at 850 hPa for summer 2013 and compared to EOFs calculated from 1979-2015 ERA-Interim reanalysis. Generally, two different phases were identified. They are related to the eastward propagation of the subtropical ridge into the Mediterranean basin, the position of the Saharan heat low, and the predominant Iberian heat low. The relation of these centres of action illustrates a dipole pattern for enhanced (reduced) dust emission fluxes, stronger (weaker) meridional dust transport, and consequent increase (decrease) atmospheric dust concentrations and deposition fluxes. In concert, the results from this study aim at illustrating the relevance of knowing the dust source locations in concert with the atmospheric circulation. Ultimately, this study addresses the question of what is finally transported towards the Mediterranean basin and Europe from which source regions - and fostered by which atmospheric circulation pattern. Outcomes from this study contribute to the understanding of varying atmospheric mineral dust contributions to the aerosol burden affecting populated areas around Europe.

A global slowdown of tropical-cyclone translation speed.

PubMed

Kossin, James P

2018-06-01

As the Earth's atmosphere warms, the atmospheric circulation changes. These changes vary by region and time of year, but there is evidence that anthropogenic warming causes a general weakening of summertime tropical circulation 1-8 . Because tropical cyclones are carried along within their ambient environmental wind, there is a plausible a priori expectation that the translation speed of tropical cyclones has slowed with warming. In addition to circulation changes, anthropogenic warming causes increases in atmospheric water-vapour capacity, which are generally expected to increase precipitation rates 9 . Rain rates near the centres of tropical cyclones are also expected to increase with increasing global temperatures 10-12 . The amount of tropical-cyclone-related rainfall that any given local area will experience is proportional to the rain rates and inversely proportional to the translation speeds of tropical cyclones. Here I show that tropical-cyclone translation speed has decreased globally by 10 per cent over the period 1949-2016, which is very likely to have compounded, and possibly dominated, any increases in local rainfall totals that may have occurred as a result of increased tropical-cyclone rain rates. The magnitude of the slowdown varies substantially by region and by latitude, but is generally consistent with expected changes in atmospheric circulation forced by anthropogenic emissions. Of particular importance is the slowdown of 30 per cent and 20 per cent over land areas affected by western North Pacific and North Atlantic tropical cyclones, respectively, and the slowdown of 19 per cent over land areas in the Australian region. The unprecedented rainfall totals associated with the 'stall' of Hurricane Harvey 13-15 over Texas in 2017 provide a notable example of the relationship between regional rainfall amounts and tropical-cyclone translation speed. Any systematic past or future change in the translation speed of tropical cyclones, particularly over land, is therefore highly relevant when considering potential changes in local rainfall totals.

Observations and modeling of ocean-induced melt beneath Petermann Glacier Ice Shelf in northwestern Greenland

NASA Astrophysics Data System (ADS)

Cai, Cilan; Rignot, Eric; Menemenlis, Dimitris; Nakayama, Yoshihiro

2017-08-01

We update observationally based estimates of subaqueous melt, Qm, beneath Petermann Glacier Ice Shelf (PGIS), Greenland, and model its sensitivity to oceanic thermal forcing, TF, and subglacial runoff, Qsg, using the Massachusetts Institute of Technology general circulation model (MITgcm), in a two-dimensional domain, with 20 m vertical and 40 m horizontal resolution at the grounding line. We adjust the drag coefficient to match the observationally based Qm. With the inclusion of Qsg, the maximum melt rate (Qmmax) is 2 times larger in summer and 1/3 larger annually than in winter. Qmmax increases above linear with TF and below linear with Qsg. We estimate that Qmmax increased by 24% (+8.1 m/yr) beneath PGIS from the 1990s to the 2000s from a 0.21°C warming in ocean temperature and a doubling in Qsg, hence contributing to its thinning. If the PGIS is removed, we estimate that the modeled melt rate near the grounding line will increase 13-16 times.

Bio-objects and the media: the role of communication in bio-objectification processes.

PubMed

Maeseele, Pieter; Allgaier, Joachim; Martinelli, Lucia

2013-06-01

The representation of biological innovations in and through communication and media practices is vital for understanding the nature of "bio-objects" and the process we call "bio-objectification." This paper discusses two ideal-typical analytical approaches based on different underlying communication models, ie, the traditional (science- and media-centered) and media sociological (a multi-layered process involving various social actors in defining the meanings of scientific and technological developments) approach. In this analysis, the latter is not only found to be the most promising approach for understanding the circulation, (re)production, and (re)configuration of meanings of bio-objects, but also to interpret the relationship between media and science. On the basis of a few selected examples, this paper highlights how media function as a primary arena for the (re)production and (re)configuration of scientific and biomedical information with regards to bio-objects in the public sphere in general, and toward decision-makers, interest groups, and the public in specific.

A gel-free proteomic-based method for the characterization of Bordetella pertussis clinical isolates

PubMed Central

Williamson, Yulanda M.; Moura, Hercules; Simmons, Kaneatra; Whitmon, Jennifer; Melnick, Nikkol; Rees, Jon; Woolfitt, Adrian; Schieltz, David M.; Tondella, Maria L.; Ades, Edwin; Sampson, Jacquelyn; Carlone, George; Barr, John R.

2017-01-01

Bordetella pertussis (Bp) is the etiologic agent of pertussis or whooping cough, a highly contagious respiratory disease occurring primarily in infants and young children. Although vaccine preventable, pertussis cases have increased over the years leading researchers to re-evaluate vaccine control strategies. Since bacterial outer membrane proteins, comprising the surfaceome, often play roles in pathogenesis and antibody-mediated immunity, three recent Bp circulating isolates were examined using proteomics to identify any potential changes in surface protein expression. Fractions enriched for outer membrane proteins were digested with trypsin and the peptides analyzed by nano liquid chromatography-electrospray ionization-mass spectrometry (nLC-ESI-MS), followed by database analysis to elucidate the surfaceomes of our three Bp isolates. Furthermore, a less labor intensive non-gel based antibody affinity capture technology in conjunction with MS was employed to assess each Bp strains' immunogenic outer membrane proteins. This novel technique is generally applicable allowing for the identification of immunogenic surface expressed proteins on pertussis and other pathogenic bacteria. PMID:22537821

Tidally induced residual current over the Malin Sea continental slope

NASA Astrophysics Data System (ADS)

Stashchuk, Nataliya; Vlasenko, Vasiliy; Hosegood, Phil; Nimmo-Smith, W. Alex M.

2017-05-01

Tidally induced residual currents generated over shelf-slope topography are investigated analytically and numerically using the Massachusetts Institute of Technology general circulation model. Observational support for the presence of such a slope current was recorded over the Malin Sea continental slope during the 88-th cruise of the RRS ;James Cook; in July 2013. A simple analytical formula developed here in the framework of time-averaged shallow water equations has been validated against a fully nonlinear nonhydrostatic numerical solution. A good agreement between analytical and numerical solutions is found for a wide range of input parameters of the tidal flow and bottom topography. In application to the Malin Shelf area both the numerical model and analytical solution predicted a northward moving current confined to the slope with its core located above the 400 m isobath and with vertically averaged maximum velocities up to 8 cm s-1, which is consistent with the in-situ data recorded at three moorings and along cross-slope transects.

Bio-objects and the media: the role of communication in bio-objectification processes

PubMed Central

Maeseele, Pieter; Allgaier, Joachim; Martinelli, Lucia

2013-01-01

The representation of biological innovations in and through communication and media practices is vital for understanding the nature of “bio-objects” and the process we call “bio-objectification.” This paper discusses two ideal-typical analytical approaches based on different underlying communication models, ie, the traditional (science- and media-centered) and media sociological (a multi-layered process involving various social actors in defining the meanings of scientific and technological developments) approach. In this analysis, the latter is not only found to be the most promising approach for understanding the circulation, (re)production, and (re)configuration of meanings of bio-objects, but also to interpret the relationship between media and science. On the basis of a few selected examples, this paper highlights how media function as a primary arena for the (re)production and (re)configuration of scientific and biomedical information with regards to bio-objects in the public sphere in general, and toward decision-makers, interest groups, and the public in specific. PMID:23771763

Molecular Characteristics of Influenza Virus Type B Lineages Circulating in Poland.

PubMed

Bednarska, K; Hallmann-Szelińska, E; Kondratiuk, K; Rabczenko, D; Brydak, L B

2016-01-01

From the time of the Hong Kong pandemic of 1968-1969, vaccines against influenza are trivalent, containing two subtypes of influenza type A: A/H1N1/ and A/H3N2/, and influenza type B. In 1980, circulation of the new Yamagata and Victoria lineages of influenza B virus was noted. Since both lineages have continued to circulate, the second lineage of influenza B was included into the trivalent vaccine as of the 2013/2014 epidemic season. In Poland, co-circulation of influenza type A and B has been registered over many seasons, although type A has predominated. According to the ACIP recommendations, quadrivalent vaccines against influenza are administered in some continents due to circulation of the B-Yamagata and B-Victoria lineages. Currently, only trivalent vaccines against influenza are available in Poland. The aim of the present research was to determine which of the two influenza type B lineages, or possibly both, would be isolated in Poland. The study was conducted with the use of RT-PCR. Generally, in the 2014/2015 epidemic season in Poland, circulation of type B virus was confirmed in 34 % of influenza cases. A total of 89 specimens of influenza B were tested, including co-infections of influenza B with influenza A subtypes: A/H1N1/pdm09 and A/H3N2/. The findings were that only lineage B-Yamagata circulates in the Polish population. Therefore, vaccines available on the Polish market do not require the introduction of a fourth component.

A modeling study on the hydrodynamics of a coastal embayment occupied by mussel farms (Ria de Ares-Betanzos, NW Iberian Peninsula)

NASA Astrophysics Data System (ADS)

Duarte, Pedro; Alvarez-Salgado, Xosé Antón; Fernández-Reiriz, Maria José; Piedracoba, Silvia; Labarta, Uxío

2014-06-01

The present study suggests that both under upwelling and downwelling winds, the residual circulation of Ria de Ares-Betanzos remains positive with a strong influence from river discharge and a positive feedback from wind, unlike what is generally accepted for Galician rias. Furthermore, mussel cultivation areas may reduce residual velocities by almost 40%, suggesting their potential feedbacks on food replenishment for cultivated mussels. The Ria de Ares-Betanzos is a partially stratified estuary in the NW Iberian upwelling system where blue mussels are extensively cultured on hanging ropes. This type of culture depends to a large extent on water circulation and residence times, since mussels feed on suspended particles. Therefore, understanding the role of tides, continental runoff, and winds on the circulation of this embayment has important practical applications. Furthermore, previous works have emphasized the potential importance of aquaculture leases on water circulation within coastal ecosystems, with potential negative feedbacks on production carrying capacity. Here we implemented and validated a 3D hydrodynamic numerical model for the Ria de Ares-Betanzos to (i) evaluate the relative importance of the forcing agents on the circulation within the ria and (ii) estimate the importance of culture leases on circulation patterns at the scale of the mussel farms from model simulations. The model was successfully validated with empirical current velocity data collected during July and October 2007 using an assortment of efficiency criteria. Model simulations were carried out to isolate the effects of wind and river flows on circulation patterns.

Utilization of virtual learning environments in the allied health professions.

PubMed

Butina, Michelle; Brooks, Donna; Dominguez, Paul J; Mahon, Gwendolyn M

2013-01-01

Multiple technology based tools have been used to enhance skill development in allied health education, which now includes virtual learning environments. The purpose of this study was to explore whether, and how, this latest instructional technology is being adapted in allied health education. An online survey was circulated to all Association of Schools of Allied Health Professions (ASAHP) member institutions and focused on three broad areas of virtual learning environments: the uses of, the perceived pros and cons of, and the outcomes of utilizing them. Results show 40% (17 of 42) of the respondent use some form of the technology. The use of virtual learning technology in other healthcare professions (e.g., medicine) demonstrates the potential benefits to allied health education.

Congenital Anomaly of Single Dominant Right Coronary Artery with Hypoplastic Left Coronary Artery.

PubMed

Chuang, Cheng-Yen; Chen, Yen-Chou; Cheng, Ho-Shun; Hsieh, Ming-Hsiung

2015-11-01

With the popularization of new imaging technology, more people are deciding to undergo non-invasive studies such as multidetector computerized tomography (MDCT) before receiving coronary angiography. For this reason, coronary anomalies of coronary artery are being encountered more frequently. We here report a 68-year-old male presenting with typical angina. The MDCT images suggested chronic total occlusion of the left anterior descending (LAD) artery with collateral circulation from the right coronary artery (RCA). The patient's coronary angiography showed a congenital coronary anomaly with a single dominant RCA supplying the entire coronary circulation of the heart with both LAD and left circumflex artery hypoplasia. Angiography; Anomaly; Computerized tomography; Coronary artery.

Inkjet-Print Micromagnet Array on Glass Slides for Immunomagnetic Enrichment of Circulating Tumor Cells

PubMed Central

Chen, Peng; Huang, Yu-Yen; Bhave, Gauri; Hoshino, Kazunori; Zhang, Xiaojing

2015-01-01

We report an inkjet-printed microscale magnetic structure that can be integrated on regular glass slides for the immunomagnetic screening of rare Circulating Tumor Cells (CTCs). CTCs detach from the primary tumor site, circulate with the bloodstream, and initiate the cancer metastasis process. Therefore, a liquid biopsy in the form of capturing and analyzing CTCs may provide key information for cancer prognosis and diagnosis. Inkjet printing technology provides a non-contact, layer-by-layer and mask-less approach to deposit defined magnetic patterns on an arbitrary substrate. Such thin film patterns, when placed in an external magnetic field, significantly enhance the attractive force in the near-field close to the CTCs to facilitate the separation. We demonstrated the efficacy of the inkjet-print micromagnet array integrated immunomagnetic assay in separating COLO205 (human colorectal cancer cell line) from whole blood samples. The micromagnets increased the capture efficiency by 26% compared with using plain glass slide as the substrate. PMID:26289942

Physically-Derived Dynamical Cores in Atmospheric General Circulation Models

NASA Technical Reports Server (NTRS)

Rood, Richard B.; Lin, Shian-Jiann

1999-01-01

The algorithm chosen to represent the advection in atmospheric models is often used as the primary attribute to classify the model. Meteorological models are generally classified as spectral or grid point, with the term grid point implying discretization using finite differences. These traditional approaches have a number of shortcomings that render them non-physical. That is, they provide approximate solutions to the conservation equations that do not obey the fundamental laws of physics. The most commonly discussed shortcomings are overshoots and undershoots which manifest themselves most overtly in the constituent continuity equation. For this reason many climate models have special algorithms to model water vapor advection. This talk focuses on the development of an atmospheric general circulation model which uses a consistent physically-based advection algorithm in all aspects of the model formulation. The shallow-water model is generalized to three dimensions and combined with the physics parameterizations of NCAR's Community Climate Model. The scientific motivation for the development is to increase the integrity of the underlying fluid dynamics so that the physics terms can be more effectively isolated, examined, and improved. The expected benefits of the new model are discussed and results from the initial integrations will be presented.

Physically-Derived Dynamical Cores in Atmospheric General Circulation Models

NASA Technical Reports Server (NTRS)

Rood, Richard B.; Lin, Shian-Kiann

1999-01-01

The algorithm chosen to represent the advection in atmospheric models is often used as the primary attribute to classify the model. Meteorological models are generally classified as spectral or grid point, with the term grid point implying discretization using finite differences. These traditional approaches have a number of shortcomings that render them non-physical. That is, they provide approximate solutions to the conservation equations that do not obey the fundamental laws of physics. The most commonly discussed shortcomings are overshoots and undershoots which manifest themselves most overtly in the constituent continuity equation. For this reason many climate models have special algorithms to model water vapor advection. This talk focuses on the development of an atmospheric general circulation model which uses a consistent physically-based advection algorithm in all aspects of the model formulation. The shallow-water model of Lin and Rood (QJRMS, 1997) is generalized to three dimensions and combined with the physics parameterizations of NCAR's Community Climate Model. The scientific motivation for the development is to increase the integrity of the underlying fluid dynamics so that the physics terms can be more effectively isolated, examined, and improved. The expected benefits of the new model are discussed and results from the initial integrations will be presented.

Clinical utility of circulating tumour cell detection in non-small-cell lung cancer.

PubMed

Fusi, Alberto; Metcalf, Robert; Krebs, Matthew; Dive, Caroline; Blackhall, Fiona

2013-12-01

Recent years have witnessed increased interest in the detection of circulating tumour cells (CTCs) for diagnosis, monitoring, and treatment decision making in patients with cancer. Factors that have led to accelerated research in this field include advances in technologies for examination of intact CTCs, personalised medicine with treatment selection according to molecular characteristics, and continued lack of understanding of the biology of treatment resistance and metastasis. CTCs offer promise as a surrogate for tissue where there is insufficient tissue for molecular analysis and where there is a requirement to serially monitor molecular changes in cancer cells through treatment or on progression. In patients with either small cell or non-small cell lung cancer (NSCLC), there is evidence that CTC number is prognostic and that CTCs counted before and after treatment mirror treatment response. In patients with molecularly defined subtypes of NSCLC, CTCs demonstrate the same molecular changes as the cancer cells of the tumour. However, CTCs are not quite ready for "primetime" in the lung cancer clinic. There are still more questions than answers with respect to the optimal technologies for their detection and analysis, their biological significance, and their clinical utility. Despite this the current pace of progress in CTC technology development seems set to make "liquid biopsies" a clinical reality within the next decade. For the everyday clinician and clinical trialist, it will be important to maintain knowledge of the strengths and weaknesses of the technologies and evolving evidence base for CTCs as a routinely used diagnostic tool.

1300°F 800 MWe USC CFB Boiler Design Study

NASA Astrophysics Data System (ADS)

Robertson, Archie; Goidich, Steve; Fan, Zhen

Concern about air emissions and the effect on global warming is one of the key factors for developing and implementing new advanced energy production solutions today. One state-of-the-art solution is circulating fluidized bed (CFB) combustion technology combined with a high efficiency once-through steam cycle. Due to this extremely high efficiency, the proven CFB technology offers a good solution for CO2 reduction. Its excellent fuel flexibility further reduces CO2 emissions by co-firing coal with biomass. Development work is under way to offer CFB technology up to 800MWe capacities with ultra-supercritical (USC) steam parameters. In 2009 a 460MWe once-through supercritical (OTSC) CFB boiler designed and constructed by Foster Wheeler will start up. However, scaling up the technology further to 600-800MWe with net efficiency of 45-50% is needed to meet the future requirements of utility operators. To support the move to these larger sizes, an 800MWe CFB boiler conceptual design study was conducted and is reported on herein. The use of USC conditions (˜11 00°F steam) was studied and then the changes, that would enable the unit to generate 1300°F steam, were identified. The study has shown that by using INTREX™ heat exchangers in a unique internal-external solids circulation arrangement, Foster Wheeler's CFB boiler configuration can easily accommodate 1300°F steam and will not require a major increase in heat transfer surface areas.

Industrial applications of hot dry rock geothermal energy

NASA Astrophysics Data System (ADS)

Duchane, D. V.

1992-07-01

Geothermal resources in the form of naturally occurring hot water or steam have been utilized for many years. While these hydrothermal resources are found in many places, the general case is that the rock at depth is hot, but does not contain significant amounts of mobile fluid. An extremely large amount of geothermal energy is found around the world in this hot dry rock (HDR). Technology has been under development for more than twenty years at the Los Alamos National Laboratory in the United States and elsewhere to develop the technology to extract the geothermal energy from HDR in a form useful for electricity generation, space heating, or industrial processing. HDR technology is especially attractive for industrial applications because of the ubiquitous distribution of the HDR resource and the unique aspects of the process developed to recover it. In the HDR process, as developed at Los Alamos, water is pumped down a well under high pressure to open up natural joints in hot rock and create an artificial geothermal reservoir. Energy is extracted by circulating water through the reservoir. Pressurized hot water is returned to the surface through the production well, and its thermal energy is extracted for practical use. The same water is then recirculated through the system to mine more geothermal heat. Construction of a pilot HDR facility at Fenton Hill, NM, USA, has recently been completed by the Los Alamos National Laboratory. It consists of a large underground reservoir, a surface plant, and the connecting wellbores. This paper describes HDR technology and the current status of the development program. Novel industrial applications of geothermal energy based on the unique characteristics of the HDR energy extraction process are discussed.

27 CFR 72.61 - Alternative methods of sale.

Code of Federal Regulations, 2010 CFR

2010-04-01

... to be placed in a newspaper of general circulation published in the judicial district wherein the... carrier may be advertised for sale, and sold, at public auction to the highest bidder on open, competitive...

Circulation policies in health science libraries.

PubMed

Watkins, C; Coker, N C

1970-10-01

There is general agreement that library policies have considerable influence on the use of libraries. Medical school (health science) libraries of this country were surveyed as to their policies in respect to whether faculty and student use were regulated by a single policy, circulation regulations, hours library was accessible to users, accessibility of reserve material, interlibrary loan, policy on overdue material, and exit control. THE LIBRARIES WERE THEN DIVIDED INTO THREE GROUPS, HIGH, MIDDLE, AND LOW ACCORDING TO THE FOLLOWING CHARACTERISTICS: size of student body, size of faculty, size of holdings, size of library staff, annual budget, and annual circulation. Our findings would indicate that schools falling in a high category based upon these criteria tend to be more restrictive in their policies and to have different regulations for faculty and students than do schools in the low category.These findings warrant further study.

The 1997/98 El Nino: A Test for Climate Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, R; Dong, B; Cess, R D

Version 3 of the Hadley Centre Atmospheric Model (HadAM3) has been used to demonstrate one means of comparing a general circulation model with observations for a specific climate perturbation, namely the strong 1997/98 El Nino. This event was characterized by the collapse of the tropical Pacific's Walker circulation, caused by the lack of a zonal sea surface temperature gradient during the El Nino. Relative to normal years, cloud altitudes were lower in the western portion of the Pacific and higher in the eastern portion. HadAM3 likewise produced the observed collapse of the Walker circulation, and it did a reasonable jobmore » of reproducing the west/east cloud structure changes. This illustrates that the 1997/98 El Nino serves as a useful means of testing cloud-climate interactions in climate models.« less

On the global circulation and the hurricane system of the Jovian atmosphere

NASA Technical Reports Server (NTRS)

Mayr, H. G.; Meada, K.; Harris, I.

1981-01-01

An argument is made to support the proposal that Jupiter's red spot and the white and brown ovals are hurricanes or cyclones. Against the background of a convectively unstable troposphere, the general condition exists for the formation of hurricanes. The energy Jupiter emits must be transported upwards through the troposphere. If that transport is accelerated by the prevailing upward motions in the solar driven multicellular meridional circulation, eastward jets develop such as observed in the l region. But if that vertical transport is impeded by the prevailing downward motions in the meridional circulation, the atmosphere reacts and tends to maintain the process through the development of hurricanes. Dynamically induced by solar differential heating, an ordered latitudinal structure with alternating stability and instability is impressed on the troposphere to form alternating zonal strata where hurricanes are forbidden and permitted, respectively.

The Influence of Indian Ocean Atmospheric Circulation on Warm Pool Hydroclimate During the Holocene Epoch

NASA Technical Reports Server (NTRS)

Tierney, J.E.; Oppo, D. W.; LeGrande, A. N.; Huang, Y.; Rosenthal, Y.; Linsley, B. K.

2012-01-01

Existing paleoclimate data suggest a complex evolution of hydroclimate within the Indo-Pacific Warm Pool (IPWP) during the Holocene epoch. Here we introduce a new leaf wax isotope record from Sulawesi, Indonesia and compare proxy water isotope data with ocean-atmosphere general circulation model (OAGCM) simulations to identify mechanisms influencing Holocene IPWP hydroclimate. Modeling simulations suggest that orbital forcing causes heterogenous changes in precipitation across the IPWP on a seasonal basis that may account for the differences in time-evolution of the proxy data at respective sites. Both the proxies and simulations suggest that precipitation variability during the September-November (SON) season is important for hydroclimate in Borneo. The preeminence of the SON season suggests that a seasonally lagged relationship between the Indian monsoon and Indian Ocean Walker circulation influences IPWP hydroclimatic variability during the Holocene.

Climatic Change and Dynamics of Northern Hemisphere Storm-tracks: Changes in Transient Eddies Behavior

NASA Astrophysics Data System (ADS)

Martynova, Yuliya; Krupchatnikov, Vladimir

2013-04-01

An evidence of our understanding of the general circulation is whether we can predict changes in the general circulation that might be associated with past or future climate changes. Changes in the location, intensity or seasonality of major climatological features of the general circulation could be more important than average temperature changes, particularly where these changes could affect local hydrology, energy balances, etc. Under these major climatological features we assume the poleward expansion of the tropical circulation (Hadley circulation), static stability (changes in the vertical temperature structure of the atmosphere), role of SST forcing, sea ice extension, extratropical eddies behavior. We have a question: would the climate change significantly affect the location and intensity of midlatitude storm-tracks and associated jets? Mean-flow interaction in midlatitudes produces low-frequency variations in the latitude of the jets. It is reasonable to think that a modest climate change might significantly affects the jets location and their associated storm tracks. The storm-tracks are defined as the region of strong baroclinicity (maximum meridional temperature gradient), which are determined on the basis of eddy statistics like eddy fluxes of angular momentum, energy, and water (with the use of high-bandpass filter). In the Northern Hemisphere, there are two major storms: in the region of Atlantic and Pacific. The storm-tracks play important role in the dynamics of weather and climate. They affect the global energy cycle and the hydrological cycle, and as a result they bring heavy rains and other hazardous weather phenomena in the middle latitudes. The recent increase in global tropopause heights is closely associated with systematic temperature changes below and above the tropopause. Temperature increases in the troposphere and decreases in the stratosphere. The pattern of warming and cooling also affects the zonal wind structure in the region of the subtropical upper troposphere and lower stratosphere (UTLS). Extratropical tropospheric eddies play a central role in this mechanism. The eddies tend to move eastward with the zonal flow and equatorward toward the subtropics until they reach their critical latitudes, where their phase speed equals the speed of the background zonal flow. This work is partially supported by the Ministry of education and science of the Russian Federation (con-tract #8345), SB RAS project VIII.80.2.1, RFBR grant #11-05-01190a, and integrated project SB RAS #131.

Influence of glacial ice sheets on the Atlantic meridional overturning circulation through surface wind change

NASA Astrophysics Data System (ADS)

Sherriff-Tadano, Sam; Abe-Ouchi, Ayako; Yoshimori, Masakazu; Oka, Akira; Chan, Wing-Le

2018-04-01

Coupled modeling studies have recently shown that the existence of the glacial ice sheets intensifies the Atlantic meridional overturning circulation (AMOC). However, most models show a strong AMOC in their simulations of the Last Glacial Maximum (LGM), which is biased compared to reconstructions that indicate both a weaker and stronger AMOC during the LGM. Therefore, a detailed investigation of the mechanism behind this intensification of the AMOC is important for a better understanding of the glacial climate and the LGM AMOC. Here, various numerical simulations are conducted to focus on the effect of wind changes due to glacial ice sheets on the AMOC and the crucial region where the wind modifies the AMOC. First, from atmospheric general circulation model experiments, the effect of glacial ice sheets on the surface wind is evaluated. Second, from ocean general circulation model experiments, the influence of the wind stress change on the AMOC is evaluated by applying wind stress anomalies regionally or at different magnitudes as a boundary condition. These experiments demonstrate that glacial ice sheets intensify the AMOC through an increase in the wind stress at the North Atlantic mid-latitudes, which is induced by the North American ice sheet. This intensification of the AMOC is caused by the increased oceanic horizontal and vertical transport of salt, while the change in sea ice transport has an opposite, though minor, effect. Experiments further show that the Eurasian ice sheet intensifies the AMOC by directly affecting the deep-water formation in the Norwegian Sea.

Sensitivity of Atlantic meridional overturning circulation to the dynamical framework in an ocean general circulation model

NASA Astrophysics Data System (ADS)

Li, Xiaolan; Yu, Yongqiang; Liu, Hailong; Lin, Pengfei

2017-06-01

The horizontal coordinate systems commonly used in most global ocean models are the spherical latitude-longitude grid and displaced poles, such as a tripolar grid. The effect of the horizontal coordinate system on Atlantic meridional overturning circulation (AMOC) is evaluated by using an OGCM (ocean general circulation model). Two experiments are conducted with the model—one using a latitude-longitude grid (referred to as Lat_1) and the other using a tripolar grid (referred to as Tri). The results show that Tri simulates a stronger North Atlantic deep water (NADW) than Lat_1, as more saline water masses enter the Greenland-Iceland-Norwegian (GIN) seas in Tri. The stronger NADW can be attributed to two factors. One is the removal of the zonal filter in Tri, which leads to an increasing of the zonal gradient of temperature and salinity, thus strengthening the north geostrophic flow. In turn, it decreases the positive subsurface temperature and salinity biases in the subtropical regions. The other may be associated with topography at the North Pole, because realistic topography is applied in the tripolar grid while the latitude-longitude grid employs an artificial island around the North Pole. In order to evaluate the effect of the filter on AMOC, three enhanced filter experiments are carried out. Compared to Lat_1, an enhanced filter can also augment NADW formation, since more saline water is suppressed in the GIN seas, but accumulated in the Labrador Sea, especially in experiment Lat_2_S, which is the experiment with an enhanced filter on salinity.

On the Planning and Design of Hospital Circulation Zones.

PubMed

Jiang, Shan; Verderber, Stephen

2017-01-01

This present literature review explores current issues and research inconsistencies regarding the design of hospital circulation zones and the associated health-related outcomes. Large general hospitals are immense, highly sophisticated institutions. Empirical studies have indicated excessively institutional environments in large medical centers are a cause of negative effects to occupants, including stress, anxiety, wayfinding difficulties and spatial disorientation, lack of cognitional control, and stress associated with inadequate access to nature. The rise of patient-centered and evidence-based movements in healthcare planning and design has resulted in a general rise in the quality of hospital physical environments. However, as a core component of any healthcare delivery system, hospital circulation zones have tended to remain neglected within the comparatively broad palette of research conducted and reported to date. A systematic literature review was conducted based upon combinations of key words developed vis-à-vis a literature search in 11 major databases in the realm of the health sciences and the planning and design of built environments for healthcare. Eleven peer-reviewed articles were included in the analysis. Six research themes were identified according to associated health-related outcomes, including wayfinding difficulties and spatial disorientation, communication and socialization patterns, measures and control of excessive noise, patient fall incidents, and occupants' stress and satisfaction levels. Several knowledge gaps as well as commonalities in the pertinent research literature were identified. Perhaps the overriding finding is that occupants' meaningful exposure to views of nature from within hospital circulation zones can potentially enhance wayfinding and spatial navigation. Future research priories on this subject are discussed.

Cell activation and cellular-cellular interactions during hemodialysis: effect of dialyzer membrane.

PubMed

Sirolli, V; Ballone, E; Di Stante, S; Amoroso, L; Bonomini, M

2002-06-01

During hemodialysis (HD), circulating blood cells can be activated and also engage in dynamic interplay. These phenomena may be important factors behind dialysis membrane bio(in)compatibility. In the present prospective cross-over study, we have used flow cytometry to evaluate the influence of different dialysis membranes on the activation of circulating blood cells (leukocytes, platelets) and their dynamic interactions (formation of circulating platelet-leukocyte and platelet-erythrocyte aggregates) during in vivo HD. Each patient (n = 10) was treated with dialyzers containing membranes of cellulose diacetate, polysulfone and ethylenevinylalcohol (EVAL) in a randomized order. Upregulation of adhesion receptor expression (CD15s, CD11b/CD18) occurred mainly with the cellulosic membrane, though an increase in CD11b/CD18 circulating on neutrophils was also found with both synthetic membranes. Circulating activated platelets (P-selectin/CD63-positive platelets) increased during HD sessions with cellulose diacetate and polysulfone. An increased formation of platelet-neutrophil aggregates was found at 15 and 30 min during dialysis with cellulose diacetate and polysulfone but not with EVAL. Platelet-erythrocyte aggregates also increased with cellulose diacetate and at 15 min with polysulfone as well. Generally in concomitance with the increase in platelet-neutrophil coaggregates, there was an increased hydrogen peroxide production by neutrophils. The results of this study indicate that cellular mechanisms can be activated during HD largely depending on the membrane material, EVAL causing less reactivity than the other two membranes. It appears that each dialysis membrane has multiple and different characteristics that may contribute to interactions with blood components. Our results also indicate that derivatizing cellulose (cellulose diacetate) may be a useful way to improve the biocompatibility of the cellulose polymer and that there may be great variability in the biocompatibility profile of synthetic membranes, dialysis with polysulfone being in general associated with a higher degree of cell activation than EVAL membrane.

Moderate to heavy cold-weather precipitation occurrences in Tehran and the associated circulation types

NASA Astrophysics Data System (ADS)

Khansalari, Sakineh; Raziei, Tayeb; Mohebalhojeh, Ali Reza; Ahmadi-Givi, Farhang

2018-02-01

Large-scale atmospheric circulations associated with 133 moderate to heavy cold-weather precipitation events recorded at Mehrabad station in Tehran, Iran, during the period 1951-2013 are analysed. To this end, the performance of un-rotated, orthogonally rotated and obliquely rotated solutions of T-mode principal component analysis (PCA) is examined in classifying the atmospheric circulations into a few representative circulation types (CTs). The T-mode PCAs were applied to the 500-hPa geopotential height for the events in a domain from 10∘E to 70∘E and from 20∘N to 50∘N. The first six leading principal components were retained and then orthogonally and obliquely rotated using varimax and promax solutions, respectively. Statistical inter-comparison of the CTs obtained using the three solutions suggests that the obliquely rotated solution is the better choice for circulation classification in the present study. The six CTs obtained using the oblique rotation were then linked to the daily total precipitation and daily mean temperature variability at Tehran station as well as to the standardized anomalies of the daily total precipitation and mean daily temperature of a dense network of stations distributed across Iran. It is found that the CTs identified, though generally comparable in producing significant precipitation in Tehran, vary in their potential to bring cold weather and generate snowfall in Tehran specifically and in the country in general. While the first three CTs give rise to regional patterns of standardized precipitation anomalies centred in Tehran, the next three CTs leave a pronounced precipitation signature almost across the whole country. As regards the standardized temperature anomalies, with the exception of one CT that causes deep and widespread negative standardized anomalies over most parts of the country, the other CTs are characterized with a dipolar structure of a deep intrusion of cold weather to the west and prevailing warm weather to the east of the country.

Modeling South Pacific Ice-Ocean Interactions in the Global Climate System

NASA Technical Reports Server (NTRS)

Holland, David M.; Jenkins, Adrian; Jacobs, Stanley S.

2001-01-01

The objective of this project has been to improve the modeling of interactions between large Antarctic ice shelves and adjacent regions of the Southern Ocean. Our larger goal is to gain a better understanding of the extent to which the ocean controls ice shelf attrition, thereby influencing the size and dynamics of the Antarctic Ice Sheet. Melting and freezing under ice shelves also impacts seawater properties, regional upwelling and sinking and the larger-scale ocean circulation. Modifying an isopycnal coordinate general circulation model for use in sub-ice shelf cavities, we found that the abrupt change in water column thickness at an ice shelf front does not form a strong barrier to buoyancy-driven circulation across the front. Outflow along the ice shelf base, driven by melting of the thickest ice, is balanced by deep inflow. Substantial effort was focused on the Filchner-Ronne cavity, where other models have been applied and time-series records are available from instruments suspended beneath the ice. A model comparison indicated that observed changes in the production of High Salinity Shelf Water could have a major impact on circulation within the cavity. This water propagates into the cavity with an asymmetric seasonal signal that has similar phasing and shape in the model and observations, and can be related to winter production at the sea surface. Even remote parts of the sub-ice shelf cavity are impacted by external forcing on sub-annual time scales. This shows that cavity circulations and products, and therefore cavity shape, will respond to interannual variability in sea ice production and longer-term climate change. The isopycnal model gives generally lower net melt rates than have been obtained from other models and oceanographic data, perhaps due to its boundary layer formulation, or the lack of tidal forcing. Work continues on a manuscript describing the Ross cavity results.

Stressed lungs: unveiling the role of circulating stress ...

EPA Pesticide Factsheets

Ozone, a major component of smog generated through the interaction of light and anthropogenic emissions, induces adverse pulmonary, cardiovascular, and systemic health effects upon inhalation. It is generally accepted that ozone-induced lung injury is mediated by its interaction with lung lining components causing local oxidative changes, which then leads to cell damage and recruitment of inflammatory cells. It is postulated that the spillover of reactive intermediates and pro-inflammatory molecules from lung to systemic circulation mediates extra-pulmonary effects. However, recent work from our laboratory supports an alternative hypothesis that circulating stress hormones, such as epinephrine and corticosterone/cortisol, are involved in mediating ozone pulmonary effects. We have shown in rats and humans that ozone increases the levels of circulating stress hormones through activation of the hypothalamus- pituitary-adrenal (HPA) axis before any measurable effects are observed in the lung. The surgical removal of adrenals diminishes circulating stress hormones and at the same time, the pulmonary effects of ozone suggesting a significant contribution of these hormones in ozone-induced lung injury and inflammation. While ozone effects in the lung have been extensively studied, the contribution of central nervous system -mediated hormonal stress response has not been examined. In order to understand the signaling pathways that might be involved in ozone-induced lun

DOE Office of Scientific and Technical Information (OSTI.GOV)

Staten, Paul; Reichler, Thomas; Lu, Jian

Tropospheric circulation shifts have strong potential to impact surface climate. But the magnitude of these shifts in a changing climate, and the attending regional hydrological changes, are difficult to project. Part of this difficulty arises from our lack of understanding of the physical mechanisms behind the circulation shifts themselves. In order to better delineate circulation shifts and their respective causes, we decompose the circulation response into (1) the "direct" response to radiative forcings themselves, and (2) the "indirect" response to changing sea surface temperatures. Using ensembles of 90-day climate model simulations with immediate switch-on forcings, including perturbed greenhouse gas concentrations,more » stratospheric ozone concentrations, and sea surface temperatures, we document the direct and indirect transient responses of the zonal mean general circulation, and investigate the roles of previously proposed mechanisms in shifting the midlatitude jet. We find that both the direct and indirect wind responses often begin in the lower stratosphere. Changes in midlatitude eddies are ubiquitous and synchronous with the midlatitude zonal wind response. Shifts in the critical latitude of wave absorption on either flank of the jet are not indicted as primary factors for the poleward shifting jet, although we see some evidence for increasing equatorward wave reflection over the southern hemisphere in response to sea surface warming. Mechanisms for the northern hemisphere jet shift are less clear.« less

Linking the South Atlantic Meridional Overturning Circulation and the Global Monsoons

NASA Astrophysics Data System (ADS)

Lopez, H.; Dong, S.; Goni, G. J.; Lee, S. K.

2016-02-01

This study tested the hypothesis whether low frequency decadal variability of the South Atlantic meridional heat transport (SAMHT) influences decadal variability of the global monsoons. A multi-century run from a state-of-the-art coupled general circulation model is used as basis for the analysis. Our findings indicate that multi-decadal variability of the South Atlantic Ocean plays a key role in modulating atmospheric circulation via interhemispheric changes in Atlantic Ocean heat content. Weaker SAMHT produces anomalous ocean heat divergence over the South Atlantic resulting in negative ocean heat content anomaly about 15 years later. This, in turn, forces a thermally direct anomalous interhemispheric Hadley circulation in the atmosphere, transporting heat from the northern hemisphere (NH) to the southern hemisphere (SH) and moisture from the SH to the NH, thereby intensify (weaken) summer (winter) monsoon in the NH and winter (summer) monsoon in the SH. Results also show that anomalous atmospheric eddies, both transient and stationary, transport heat northward in both hemispheres producing eddy heat flux convergence (divergence) in the NH (SH) around 15-30°, reinforcing the anomalous Hadley circulation. Overall, SAMHT decadal variability leads its atmospheric response by about 15 years, suggesting that the South Atlantic is a potential predictor of global climate variability.

Large-Scale Circulation and Climate Variability. Chapter 5

NASA Technical Reports Server (NTRS)

Perlwitz, J.; Knutson, T.; Kossin, J. P.; LeGrande, A. N.

2017-01-01

The causes of regional climate trends cannot be understood without considering the impact of variations in large-scale atmospheric circulation and an assessment of the role of internally generated climate variability. There are contributions to regional climate trends from changes in large-scale latitudinal circulation, which is generally organized into three cells in each hemisphere-Hadley cell, Ferrell cell and Polar cell-and which determines the location of subtropical dry zones and midlatitude jet streams. These circulation cells are expected to shift poleward during warmer periods, which could result in poleward shifts in precipitation patterns, affecting natural ecosystems, agriculture, and water resources. In addition, regional climate can be strongly affected by non-local responses to recurring patterns (or modes) of variability of the atmospheric circulation or the coupled atmosphere-ocean system. These modes of variability represent preferred spatial patterns and their temporal variation. They account for gross features in variance and for teleconnections which describe climate links between geographically separated regions. Modes of variability are often described as a product of a spatial climate pattern and an associated climate index time series that are identified based on statistical methods like Principal Component Analysis (PC analysis), which is also called Empirical Orthogonal Function Analysis (EOF analysis), and cluster analysis.

A synergistic glance at the prospects of distributed propulsion technology and the electric aircraft concept for future unmanned air vehicles and commercial/military aviation

NASA Astrophysics Data System (ADS)

Gohardani, Amir S.

2013-02-01

Distributed propulsion is one of the revolutionary candidates for future aircraft propulsion. In this journal article, the potential role of distributed propulsion technology in future aviation is investigated. Following a historical journey that revisits distributed propulsion technology in unmanned air vehicles and military aircraft, features of this specific technology are highlighted in synergy with an electric aircraft concept and a first-of-a-kind comparison to commercial aircraft employing distributed propulsion arrangements. In light of propulsion-airframe integration and complementary technologies such as boundary layer ingestion, thrust vectoring and circulation control, transpired opportunities and challenges are addressed in addition to a number of identified research directions proposed for future aircraft. The motivation behind enhanced means of communication between engineers, researchers and scientists has stimulated a novel proposed definition for the distributed propulsion technology in aviation and is presented herein.

Biogeochemical Proxies in Scleractinian Corals used to Reconstruct Ocean Circulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guilderson, T.P.; Kashgarian, M.; Schrag, D.P.

We utilize monthly {sup 14}C data derived from coral archives in conjunction with ocean circulation models to address two questions: (1) how does the shallow circulation of the tropical Pacific vary on seasonal to decadal time scales and (2) which dynamic processes determine the mean vertical structure of the equatorial Pacific thermocline. Our results directly impact the understanding of global climate events such as the El Nino-Southern Oscillation (ENSO). To study changes in ocean circulation and water mass distribution involved in the genesis and evolution of ENSO and decadal climate variability, it is necessary to have records of climate variablesmore » several decades in length. Continuous instrumental records are limited because technology for continuous monitoring of ocean currents has only recently been available, and ships of opportunity archives such as COADS contain large spatial and temporal biases. In addition, temperature and salinity in surface waters are not conservative and thus can not be independently relied upon to trace water masses, reducing the utility of historical observations. Radiocarbon ({sup 14}C) in sea water is a quasi-conservative water mass tracer and is incorporated into coral skeletal material, thus coral {sup 14}C records can be used to reconstruct changes in shallow circulation that would be difficult to characterize using instrumental data. High resolution {Delta}{sup 14}C timeseries such as these, provide a powerful constraint on the rate of surface ocean mixing and hold great promise to augment onetime surveys such as GEOSECS and WOCE. These data not only provide fundamental information about the shallow circulation of the Pacific, but can be used as a benchmark for the next generation of high resolution ocean models used in prognosticating climate change.« less